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                            Funding & Awards
 Use of LC/MS/MS to Rapidly Perform First-Pass Screening for Drugs and Poisons in Postmortem Toxicology Cases
Award Information
Awardee
              Georgia Bureau of Investigation
Award #
              2003-IJ-CX-K007
Funding Category
              Competitive
Location
                    Decatur, GA
Congressional District
              5
Status
              Closed
Funding First Awarded
              2003
Total funding (to date)
              $407,451
Original Solicitation
              General Forensic Research and  Development for FY 2003
Description of original award (Fiscal Year 2003, $407,451)
The purpose of this grant application is to investigate the feasibility of using electrospray ionization/liquid chromatography/tandem mass spectrometry (ESI/LC/MS/MS) as replacement methodology for enzyme immunoassay (EIA) in order to perform a comprehensive screen for drugs and poisons in postmortem samples.  This approach builds on our expertise in our already validated and published procedure for the rapid analysis of whole blood and other autopsy specimens using EIA. This procedure has gained worldwide recognition for its usefulness and reliability.  Our goal is to further enhance this established procedure by using the protein precipitate methodology currently used for EIA and adapt it for use by LC/MS/MS in the analysis of biological fluids and tissues.  Such a procedure will expand significantly the number of drugs and poisons that may be screened than just using EIA alone. Furthermore, this procedure will be a less expensive alternative for drug screening, since expensive EIA reagents will then be obviated. The further advantage of this procedure is that only a straightforward and rapid extraction will be required to test for over hundred drugs using LC/MS/MS.



  
Grant-Funded Publications
        
                      Taking the Initiative: Practitioners Who Perform Frontline Research
                                                                      NIJ Journal,
                  Investigation of a Unique Adjunct to Enzyme Immunoassay in Order to Rapidly Perform First-Pass Screening for Drugs and Poisons in Postmortem Toxicology Cases

  
Date Created: September 29, 2003
    
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