### Federal Register / Vol. 59, No. 249 / Thursday December 29, 1994 / Notices

ENVIRONMENTAL PROTECTION AGENCY [OPPTS-41042; FRL-4923-2] Thirty-Fifth Report ofthe TSCA Interagency Testing Committee to the Administrator Receipt of Report, Request forComments, Solicitationof Interested Parties in Developing Testing Consent Agreement
AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY* The TSCA Interagency Testing Committee (ITC), establishedunder section 4(e) ofthe Toxic Substances ControlAct (TSCA), transmitted its Thirty-Fifth Report to the Administrator ofEPA on November 3, 1994. As noted in thisReport, which is included with this notice, the ITC revised the Priority Testing Listby designating a group of25 chemicals to the List for priority consideration by the Administrator for promulgation oftest rules under section 4(a) ofthe Act. These chemicals are designated for response within 12 months. Therefore, in response to the ITC's designation, EPA will either initiate rulemaking under section 4(a) ofTSCA, enter into
a testing consent agreement, orpublish
a Federal Register notice explaining the
reasons for notinitiating such rulemaking within 12months. The ITC also removed 110 of123 previously recommended chemicals from the List. The ITC removed 28 of43 isocyanates, 27 of89 aldehydes, 25 of26 sulfones, 7 of 11 cyanoacrylates, 4 of 14 diaryl ethers and 19 of 35 chemicals originally recommended for subchronic (90-day) toxicity testing. The ITC's reasons for removing these chemicals from the List
are listed in the Thirty-Fifth Report. There are no recommended with intentto-designate or recommended chemicals
or chemical groups inthe Thirty-Fifth Report. EPA invites interested persons to submit written comments on the Report.

In addition, EPA is soliciting interested parties for participation in or monitoring of aTSCA section 4 testing consent agreement development process for the chemicals thatwere designated for dermal absorption testing. EPA is also inviting manufacturers and/or processors ofchemical substances who wish to participate in testing negotiations forthe chemicals designated for dermal absorption testing ,to develop and submit testing agreement proposals to EPA. DATES: Written comments on the ThirtyFifth ITCReport shouldbe submitted by January 30, 1995. Written testing proposals must be received by February 27 1995. Written notice ofinterest in being designated an "interested party" to the development ormonitoring ofa consent agreement for the chemicals designated for dermal absorption testing. must bereceived byFebruary 27 1995. Those submitting written testing proposals will be considered "interested parties" and do nothave to submit separate written notice. EPA will contact all "interested parties" and advise them ofmeeting dates. ADDRESSES: Send six copies ofwritten submissions to: TSCA Nonconfidential Information Center (7407), Office of Pollution Prevention and Toxics, Environmental Protection Agency Rm. B-607 NEM, 401 M St., SW., Washington, DC 20460. Submissions should bearthe document control number (OPPTS-41042; FRL-4923-2).

The public record supporting this action, including comments, is available for public inspection in Rm. B-607 NEM atthe address noted above from 12
noon to 4 p.m., Monday through Friday except legal holidays. FOR FURTHER INFORMATION CONTACT: Susan B. Hazen, Director, Environmental Assistance Division (7408), Office ofPollution Prevention and Toxics, Environmental Protection Agency, 401 M St., SW., Rm. E-543B, Washington, DC 20460, (202) 554-1404, TDD (202) 554-0551. SUPPLEMENTARY INFORMATION: EPA has received theTSCA Interagency Testing Committee's Thirty-Fifth Report to the Administrator. I. Background

TSCA (Pub. L. 94-469, 90 Stat. 2003 et seq; 15 U.S.C. 2601 et seq.) authorizes the Administrator ofEPA to promulgate regulations under section 4(a) requiring testing ofchemicals and chemical groups in orderto develop data relevant to determining the risks that such chemicals and chemical groups may present to health orthe environment. Section 4(e) of TSCA established the Interagency Testing Committee to recommend chemicals and chemical groups to the Administrator ofEPA for prioritytesting consideration. Section 4(e) directs the ITC to revise the TSCA section 4(e) Priority Testing List atleast every 6 months. The most recent revisions to this List are included in the ITC's Thirty-Fifth Report. The Report
was received by the Administrator on November 3, 1994, and is included in this Notice. The Report designates a group of 25 chemicals, and removes 110 of 123 previously recommended chemicals from the TSCA section 4(e) Priority Testing List. II. Written and Oral Comments

EPA invites interested persons to submit detailed comments on the ITC's Report. All submissions should bear the identifying docket number (OPPTS41042).

EPA invites interested persons to submit detailed comments on the ITC's
new recommendations. The Agency is interested in receiving information concerning additional or ongoing health and safety studies on the subject chemicals as well as information relating to the human and environmental exposure to these chemicals.

A notice will be published at alater date in the Federal Register adding certain ofthe substances recommended inthe ITC's Thirty-Fifth Report to the TSCA section 8(d) Health and Safety Data Reporting Rule (40 CFR part 716), which requires the reporting of unpublished health and safety studies
on the listed chemicals. Thatnotice will also add the chemicals to the TSCA section 8(a) Preliminary Assessment Information Rule (40 CFR part 712). The section 8(a) rule requires the reporting ofproduction volume, use, exposure, and release information on the listed chemicals. III. Status ofList

The ITC's Thirty-Fifth Report notes the designation of 25 chemicals and-the removal of 110 chemicals from the Priority Testing List. The current TSCA section 4(e) Priority Testing List contains 13 chemicals and 12 chemical groups, with 3 chemical groups and 3 chemicals designated for testing. IV Testing Consent Agreements

1. Solicitationofinterested parties. EPA's procedures forrequiring the testing ofchemical substances under section 4 ofTSCA include the adoption ofenforceable consent agreements and the promulgation oftest rules. These processes are found at 40 CFR 790.20. EPA has on numerous occasions been approached by chemical companies interested in negotiating consent agreements fortesting ITC chemicals or chemical groups. As a result ofthese requests, EPA is now inviting persons interested in participating in or monitoring negotiations on the chemical designated inthe Thirty-Fifth ITC. Report to notify EPA in writing. Those who respond to this solicitation by the deadline established inthis notice will have the status of "interested parties" and will be afforded opportunities to participate in the negotiation process. 

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These "interested parties" willnot incur any obligations by being designated "interested parties."

2. Solicitationoftestingproposals for consentagreementnegotiations. EPA is also now soliciting testing proposals for
aconsent agreement to perform dermal absorption testing on the 25 chemicals designated in the Thirty-Fifth Report. While solicitation is separate from the solicitation ofinterested parties made forthe 24 substances designated in the Thirty-First ITC Report published May 5, 1993 (58 FR 26898), and the 34 substances designated in the ThirtySecond Report published July 16, 1993 (58 FR38490), EPA expects that any testing consent agreement adopted for this effort, as well as the testing method referenced, will be substantially similar. (Note: Two ofthese chemicals were removed in the Thirty-Fourth Report). Following publication ofthlsnotice, manufacturers and/or processors have 60 days to develop and submit testing proposals forany ofthe chemical substances designated in the ThirtyFifth Report that they wishEPA to consider as candidates for consent agreement negotiations.

Federal scientists from a number of the ITC's statutory and liaison organizations, including the Consumer Product Safety Commission, Environmental Protection Agency, Food and Drug Administration, National Institute ofOccupational Safety and Health, and Occupational Safety and Health Administration, have developed
aproposed test protocol that will provide data needed by several U.S. Government Organizations represented
on the ITC. This proposed protocol is entitled "Protocol for in vitro 0ercutaneous Absorption Studies" and is available to the public through the TSCA Nonconfidential Information Center and the Environmental Assistance Division listed above. This document shouldbe reviewed before submitting any testing proposals in response to thisnotice.

Comments onthe proposed protocol that were submitted inresponse to the Thirty-First ITC Report (Docket OPPTS 41038) and the Thirty-Second ITC Report (Docket OPPTS 41039) will be incorporated in the docket forthis notice and need notbe resubmitted.

For additional technical information
on this testing protocol contact Dr.John D. Walker, Executive Director, TSCA Interagency Testing Committee, (202) 260-1820.

All testing proposals submitted should describe the testing to be performed and explain any deviations from the testprotocol that are necessary 

### to assure the development ofreliable percutaneous absorption data.

EPA willreview the submissions and select themost promising submissions as candidates fornegotiation. Submissions that fully addressthe ITC's
concerns willhave a higher chance of success than those that donotfully addressall data needs.

3. Negotiationoftesting programand 

### developmentofatestingconsent agreement.EPA will follow the negotiation procedures under 40 CFR 790.22, and tothe extent feasible, the timetable outlined in 40 CFR part 790, appendix Ato subpartB.

For additionalinformation about process or negotiations contact Frank Kover,Chief, Chencal Testing and Information Branch, (202) 260-8130.

Authority: 15U.S.C. 2603. Dated: December 20, 1994. CharlesM. Auer, Director, ChemicalControl Division,Office of

PollutionPreventionandToxics. 

### Administrator, U.S. Environmental Protection Agency SUMMARY: This is the 35th Report ofthe TSCA Interagency Testing Committee (ITC)to the Administrator ofthe U.S. Environmental Protection Agency 

### (EPA). In thisReport, theITCisrevising itsTSCA section 4(e)Priority Testing Listby designatinga group of25 chemicals fordermal absorption testing because they are ofregulatory interest to the Occupational Safety andHealth Administration (OSHA). The ITCis also revising its Listbyremoving recommended chemicals, including 28 of43 isocyanates, 27 of89 aldehydes, 25 of26 sulfones, 7 of 11 cyanoacrylates, 4 of 14 diaryl ethers and 19of35 chemicals originally recommended for subchronic (90-day) toxicity testing. 1.Background

The TSCA Interagency Testing Committee (ITC)was established by section 4(e) ofthe Toxic Substances Control Act (TSCA) "tomake recommendations tothe-Administrator respecting the chemical substances and mixtures towhich the Administrator should give priority consideration for the promulgation ofa rule fortesting under section 4(a).... Atleast every 6 months.... the Committee shall make such revisions inthe List asit determines tobe necessary and to transmit them tothe Administrator together with the Committee's reasons for the revisions" (PublicLaw 94-469, 90 Stat. 2003 etseq., 15 U.S.C. 2601 et seq.). Since its creation in 1976,the ITC has submitted 34 semi-annual Reports to the EPA Administrator transmitting the Priority Testing List and its revisions. These Reports have been publishedin the Federal Register and
are available from the ITC.The ITC meetsmonthly and produces its revisions withthe help ofstaffand technical contract support provided by EPA. ITCmembership and support personnel are listed at the end ofthis Report.

Following receipt oftheITC's Report and the addition ofchemicals to the Priority Testing List, the EPA's Office of PollutionPrevention and Toxics adds
new chemicals from the Listto TSCA section 8(a) and8(d) rules thatrequire manufacturers, processors, and/or distributors ofthese chemicals to submit TSCA section 8(a) production and exposure data and TSCA section 8(d) health and safety studies, within 60 days ofthe rule's effective date. The submissions are indexed and maintained by EPA. The ITCreviews the section 8(a) and 8(d) information and other available data on chemicals and chemical groups (e.g.,TSCA section 8(e) "substantial risk" studies, "For Your Information" (FYI) submissions to EPA, and published papers) to determine ifrevisions to the List are necessary. Revisions can include changing a recommendation to a designation for action by the Administrator within 12 months, modifying the recommended testing, or removing the chemical orchemical group from theList.
Il. Revisions to the TSCA Section 4(e) Priority Testing List

The ITC's revisions to its TSCA Section 4(e) Priority Testing List are summarized in Table 1.
TABLE 1.-CHEMICALS DESIGNATED OR REMOVED FROM THE TSCA SECTION 4(e) PRIORITY TESTING LIST Cherncal/Group Action Date

25 Chemicals

with insufficient dermal absorption data. 28 Isocyanates

...

25 Suffones
........ Designate for

Dermal Absorption Testing Remove Previously Recommended Chemicals Remove Previously Recommended Chemicals 11/94

11/94

11/94 

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TABLE 

### 1 -CHEMICALS DESIGNATED. OR REMOVED FROM THE 

### TSCA SECTION 

### 4(e) PRIORITY TESTING LIST-Continued Chemical/Group Action Date 18Chemricals Remove Pre- 11/94

with insufficient viously Recsubchronic (90- ommended day)toxicity Chemicals data. 27 Aldehydes

..... Remove Pre- .11/94 viously Recommended Chemicals 7Cyanoacrylates Remove Pre- 11/94 viously Recommended Chemicals 4 Diaryl ethers

.... Remove Pre- 11/94 viously Recommended Chemicals

III. Rationale for the Revisions A. ITC'sActivitiesDuringthisReporting Period

During the 6 months covered by this Report, May through October 1994, the ITC reviewed dermal absorption data for 63 chemicals with dermal LD50 values, and 1989 production volumes greater than I million pounds. The ITCalso reviewed the TSCA section 8(a) and section 8(d) submissions and other available data for 43 isocyanates that
were recommended in the ITC's 26th Report (55 FR 23050, June 5, 1990) as well as 26 sulfones and 35 chemicals with insufficient subchronic (g0-day) toxicity datathat were recommended in the ITC's27th Report (56 FR9534, March 6, 1991). In addition,the ITC rewiewed the production volume data obtained under the 1990 TSCA Inventory Update Rule and TSCA section 8(a)Preliminary Assessment Information Reporting rules for 89 aldehydes thatwererecommended in the ITC's 27th Report, 11 cyanoacrylates that were recommended in the ITC's 28th Report (56 FR 41212, August 19, 1991) and 14 diaryl ethers that were recommended in the ITC's 29th Report (56 FR 67424, December 30, 1991). Based onthese reviews, the ITC decided which chemicals in these groupsto designate fortesting, to retain onthe Priority Testing List or to remove from the List. B. SpecificRationales

1. Designated chemicals-a. Chemicalswithinsufficientdermal absorption data.OSHA previously established Permissible Exposure Limits (PELs) for chemical substances and 

### mixtures to'limitworkers!exposure to industrial chemicals. In general, PELs
are based on inhalation ofairborne dusts and vapors. Inthose cases where chemical absorption through the skin could be harmful, the chemicals with PELs are assigned skin notations. OSHA needs quantitative measures of dermal absorption to evaluate potential hazards to workers.

In September 1991, OSHA nominated chemical substances and mixtures with PELs to the ITC to assess the availability ofdermal absorption data. OSHA requested that ITC use its TSCA section., 4(e) statutory authority to designate chemicals with insufficient dermal absorption data for priority testing consideration. As described in previous ITCreports, the chemicals were organized into groups to facilitate review. In its 31st report, the ITC designated a group of 24 chemicals for dermal absorption testing for whichno dermal toxicity orabsorption data could be located in the publicly available literature. In its 32nd report, the ITC designated a group of 34 chemicals for dermal absorption testingbecause existing dermal toxicity and absorption data were insufficient forOSHA's needs. In the 34th report, the ITC removed two ofthe previously designated chemicals from the Priority Testing Listbecause dermal absorption data to meet OSHA's needs were obtained.

Over the past year,the ITC began to review a group of429 chemicals that have rabbit dermal LDso values in RTECS. Relevant information regarding dermal absorption, production volume, exposure and use, health effects and physicochemical properties were evaluated. The ITCreviewed 63 ofthese chemicals, all ofwhich had 1989 production volumes greater than 1 million pounds, and is designating 25 chemicals determined to have insufficient dermal absorption data to meet OSHA's needs inthe following Table 2. The ITC is continuing to review the remaimng chemicals.
TABLE 2.-CHEMICALS WITH INSUFFICIENT DERMAL ABSORPTION DATA THAT ARE BEING DESIGNATED FOR DERMAL ABSORPTION TESTING
CAS No Chemical Name
75-05-8

..... 75-12-7

..... 75-35-4

..... 77-73-6

..... 78-59-1
..... 78-83-1

..... 78-87-5

...... 91-20-3

...... Acetonitrile Formamide Vinylidene chlonde Dicyclopentadiene Isophorone Isobutyl alcohol Propylene dichlonde Naphthalene TABLE 2.---CHEMICALS WITH INSUFFICIENT DERMAL ABSORPTION DATA THAT ARE BEING DESIGNATED FOR DERMAL ABSORPTION TESTING

### Continued
CAS No. Chemical Name
92-52-4

..... Biphenyl 95-50-1

...... o-Dichlorobenzene 96-18-4

..... 1,2,3-Tnchloropropane 98--29-3

..... t-Butylcatechol 99-08-1

...... m-Nitrotoluene 99-99-0

.... p.Nitrotoluene 106-46-7

... p-Dichlorobenzene 107-06-2

.... Ethylene dichloride 108-93-0

... Cyclohexanol 108-94-1

... Cyclohexanone 110-12-3

... Methy soamyl ketone 120-80-9

... Catechol 121-69-7

... Dimethylaniline 123-42-2

... Diacetone alcohol 127-19-5

.... Dimethyl acetamude 542-92-7

... Cyclopentadiene 34590-94-8 Dipropylene glycol methyl ether

2. Removalofchemicals from the PriorityTestingLst-a.Previously recommendedchemicals forwhich productionvolume andexposuredata andhealthandsafetystudieshavebeen reviewed.For threepreviously recommended chemical groups (isocyanates, sulfones and chemicals with insufficient subchromc (90-day) toxicity data), the ITC reviewed the 1989 production volume datathat were submitted in response to EPA's September 27 1990, TSCA section 8(a) Partial Inventory UpdateRule (55 FR 39586). In addition, the ITC reviewed the production and exposure data and" health and safety studies that were submitted,in response to EPA's September 28, 1990, TSCA section 8(a) Preliminary Assessment Information Reporting (PAIR)Rule and TSCA section 8(d) Health and Safety Data Reporting Rule for isocyanates (55 FR 39586) and EPA's August 29, 1991, PAIRand Health and Safety Data Reporting Rule for sulfones and chemicals with insufficient subchronic (90-day) toxicity data (56FR 42688). For these chemical groups, theITC also requested, received andreviewed, use and exposure data from several companies, studiesthat have been published since the ITCrecommended these chemicals fortesting,TSCA section 8(e) andFYI studies, unpublished data from tests conducted by the U.S. Government organizations represented onthe ITC and data from the 1981-1983 National Occupational Exposure Survey (NOES). After reviewing these data and considering the data needs ofU.S. Government organizations represented on the ITC, the ITC decided which chemicals in 

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these groups should beremoved from the Priority Testing List. Thechemicals in these groups that were removed from theList and the rationales for removing them are described below.

.1. Isocyanates. The ITCtransmitted its 26thReport to the EPA Administrator
on May 8, 1990, and recommended a group of43 isocyanates for physical and chemical property testing inresponse to
a nomination from the EPA to support its TSCA New Chemicals Program. (55 FR 23050, June 5, 1990). The ITCis removing 27 isocyanates from the Priority Testing Listbecause annual production volumes were less than 1 million pounds or there appeared to be low potential forexposure. The ITC is also removing methyl isocyanate from the List because its physical and chemical properties.appear tobe well characterized. The 28 isocyanates that ITC isremoving from the List are included in the following Table 3.

TABLE 3.-ISOCYANATES REMOVED FROM THE PRIORITY TESTING LIST
CAS No. Chemical Name
91-97-4

..... 100-28-7

.... 104-49-4

... 109-90-0

.... 110-78-1

.... 112-96-9

... 123-61-5

... 614-68-6

... 4,4'-Diisocyanato-3,3'- dimethylbiphenyl p-Nitrophenyl isocyanate p-Phenylene diisocyanate Ethyl isocyanate n-Propyl isocyanate Octadecyl isocyanate 1,3-Diisocyanatobenzene 1-Isocyanato-2-methylbenzene TABLE 3.-ISOCYANATES REMOVED FROM THE PRIORITY TESTING LIST

### Continued
CAS No. Chemical Name 622-58-2

... 1 

### -Isocyanato-4-methylbenzene 624-83-9

... Methyl 

### isocyanate 1476-23-9 3-isocyanato-1 -propene 2422-91-5 1,1' 1"-Methylidynetns(4- isocyanatobenzene) 2493-02-9 1 -Bromo-4-isocyanatobenzene 2909-38-8 1 -Chloro-3-isocyanatobenzene 2949-22-6 Ethyl isocyanatoacetate 4151-5

....... 1-3-Tris(4-isocyanatophenyl) thiophosphate 10031-75-1 Diphenylmethylene diisocyanate 15646-96-5 1,6-Diisocyanato-2,4,4- trimethylhexane 16938-22-0 1,6-Diisocyanato-2,2,4- tnmethylhexane 25854-16-4 Bis(isocyanatomethyl)benzene 26603-40-7 1,3,5-Tris(3- isocyanatomethylphenyl)-1,3,5-triazine2,4,6(1H,3H,5H)-trone 26747-90-0 Toluene diisocyanatedimer 28178-42-9 2,6-Diisopropylphenyl isocyanate 28556-81-2 2-socyanato-1,3- dimethylbenzene 30674-80-7 2-Isocyanatoethyl methacrylate 34893-92-0 3,5-Dichlorophenyl isocyanate 68239-06-5 2-Heptyl-3,4-bis(9- isocyanatononyl)-l

- pentylcyclohexane 73597-26-9 Isophorone diisocyanate, hydroxyethyl methacrylate adduct 2. Sulfones. Inits 27th Report, the ITC recommended a group of26 sulfones for physical and chemical property testing to estimate whether occupational exposures or environmental releases
were likely to occur (56 FR 9534, March 6, 1991). This recommendation was based on the results ofthe ITC's 6th Scoring Exercise and thieuse ofthe ITC's Substructure-based Computerized Chemical Selection Expert System (SuCCSES) to identify chemical groups with common chemical substructures,
common exposure or adverse effects potentials and common data insufficiencies. The Scoring Exercise and SuCCSES have been previously described by Walker,and Brink (Ref. 1) and Walker (Refs. 2 and 3). SuCCSES
was used to identify sulfones with insufficient physical/chemical properties. Based on a review ofthe data and other considerations, the ITCis removing 25 sulfones from thePriority Testing List that are listed in the following Table 4.

TABLE 4.--.SULFONES REMOVED FROM THE PRIORITY TESTING LIST

Chemical Name
Sul/ones removed because there appeared to be low exposure potential based on annual production volume and NOES data: 67-71-0
................................................................................................ 80-08-0

................................................................................................. 98-30-6

................................................................................................ 127-63-9

.............................................................................................. 2580-77-0

............................................................................................ 3278-22-6

............................................................................................ 5246-57-1

............................................................................................ 16588-67-3

.......................................................................................... 17557-67-4

.......................................................................................... 17601-96-6
.......................................................................................... 17688-68-5

.......................................................................................... 17741-62-7

.......................................................................................... 20018-09-1

.......................................................................................... 26750-5-5

.......................................................................................... 36724-43-3
.......................................................................................... 41123-59-5

.......................................................................................... 41123-69-7

.......................................................................................... 41687-30-3

.......................................................................................... 52218-35-6

.......................................................................................... 53061-10-2
.......................................................................................... 63134-33-8

.......................................................................................... Sulfones removed beF-ause testing recommendations are currently a

lower priority than others: 77-79-2

................................................................................................ 80-09-1

................................................................................................ Dimethylsulfone 4,4'-Diaminodiphenyl sulfone 2-Amino-4-(methylsulfonyl)pheno Diphenylsulfone 2,2'-Sulfonyl bisethanol 1,1'-[Methylene bis(sulfonyl)]bisethene 2-[(3-Aminophenyl)sulfonyl]-ethanol3-[N-Ethyl-4-[[6-(methylsulfonyl)-2-benzothiazolyl]azo]-m-toludino]-propionitrile 6-Methylsulfonyl)-2-benzothiazolamine 2-Amino-4-[(2-hydroxyethyl)sulfonyllphenol 4-Phenylthiomorpholine, 1,1-dioxide 4-[4-[(2,6-Dichloro-4-nitrophenyl)azo]phenyl]-thiomorpholine, 1,1

dioxide1-(Diiodomethyl)sulfonyl-4-methyl benzene 1,1'-[Oxybis(methylenesulfonyl)] bisethene 2,2'-[Oxybis(methylenesulfonyl)] bisethanol 1,1'-[Methylenebis(sulfonyl)] bis-2-chloroethane 2,2'-[Methylenebis(sulfonyl)] bisethanol 2-[(3-Nitrophenyl)sulfonyl] ethanol 2-[(6-Amino-2-naphthalenyl)sulfonyl ethanol 1,1 '-[Oxybis(methylenesulfonyl) bis-2-chloroethane 4-[[4-(Phenylmethoxy)phenyl]-sulfonyl] phenol

Sulfolene Bisphenol S CAS No. 

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TABLE 

### 4.- SULFONES REMOVED FROM THE PRIORITY TESTING LiST-Continued
CAS No. Chemical Name
126-33-0

.............................................................................................. Suffolane 18760-44-6

.............................................................................................. 3-(Decyloxy)tetrahydrothiophene 1,1-dioxide

3. 

### Chemicals previously recommended fer subchronic(90-day) toxicitytesting.On May 17 1987 the ITC convened a public meeting to discuss the results ofthe its 6th Scoring Exercise, development ofSuCCSES and
a listof 166 substantially produced 

### chemicals (i.e., chemicals with 1985 production volumes > 1million pounds) that were coded in SuCCSES forexposure and adverse effects potentials. Based on a review of available data, the ITC recommended a group of35 chemicals in its 27th Report 

### that did not have 90-day subchromc toxicity test data (56FR 9534, March 6, 1991). Based on a review ofthe data submitted toEPA andother considerations, the ITC is removing 18 

### chemicals from the Priority Testing List that are listed in the following Table 5.
TABLE 5.-CHEMICALS PREVIOUSLY RECOMMENDED FOR SUBCHRONIC (90-DAY) TOXICITY TESTING REMOVED FROMTHE PRIORITY TESTING LIST

CAS No. Chemical Name
Chemicals removed because there appeared to be low exposure po-

tential based on annual production volume and use data: 84-51-5
................................................................................................ 87-02-5
................................................................................................ 95-32-9
................................................................................................ 98-48--6
................................................................................................ 99-63-8
................................................................................................ 100-20-9
.............................................................................................. 106-31-0
.............................................................................................. 116-81-4
.............................................................................................. 123-62-6
.............................................................................................. 616-21-7
.............................................................................................. 760-23-6
.............................................................................................. 1111-78-0
............................................................................................ Chemicals removed because Screening Information Data Set dossiers

have been developed and the need for 90-day subchronic toxicity tests will be considered by representativesfrom OECD countries that review these dossiers: 92-70-6
................................................................................................ 102-01-2
.............................................................................................. Chemicals removed because subchronic (90-day) toxicity testing rec

ommendations are currently a lower prioritythan other: 123-54-6
.............................................................................................. 311-89-7
.............................................................................................. 355-42-0
.............................................................................................. 1047-16-1

....................................... 2-Ethylanthraquinone 7-Amino-4-hydroxy-2-naphthalenesulfonic acid 2-(4-Morpholinyldithio)-benzothiazole 1,3-Benzenedisulfonic Acid Isophthaloyl chloride Terephthaloyl chloride Butyric anhydride Bromamine acid Propanoic anhydride 1,2-Dichlorobutane 3,4-Dichlorobutene Ammonium carbamate

3-Hydroxy-2-naphthoic acid Acetoacetanilide

2,4-Pentanedione Perfluorotributylamine Perfluoro-N-hexane Quinacridone

b.Previouslyrecommendedchemicals forwhichproductionvolume datahave been reviewed.For three previously recommended chemical groups (aldehydes, cyanoacrylates and diaryl ethers), the ITC reviewed the 1989 production volume data that were submitted in response to EPA's September 27 1990, TSCA section 8(a) Partial Inventory Update Rule (55 FR 39586). In addition, the ITC reviewed the production and exposure data that were submitted in response to EPA's August 29, 1991 PAIRrule for aldehydes (56 FR 42688), to EPA's December 27 1993 PAIR rule for cyanoacrylates (58 FR 68317) and to EPA's March 12, 1993 PAIR rule for diaryl ethers (58 FR 13556). After reviewing these data, the ITC decided to
remove chemicals inthese groups from the Priority Testing Listthat had production volumes less than 10,000 pounds per year. 1. 

### Aldehydes. The ITCsubmitted its 27th Report to the EPA Admimstrator
on November 19, 1990, and 

### recommended a group of89 aldehydes for aquatictoxicity testing mresponse to a nomination from the EPA to support itsTSCA NewChemicals Program (56FR 9534, March 6, 1991). Based ona review ofproduction volume data, the ITC isremoving 27aldehydes fromthe Priority Testing List.'These aldehydes are listed im the following 

### Table 6.

TABLE 6.-ALDEHYDES REMOVED FROM THE PRIORITY. TESTING LIST
CAS No. 1- 66-77-3
.................................................................................................... 78-85-3
.................................................................................................... 93-53-8

.................................................................................................... 95-01-2

.................................................................................................... 97-51-8

.................................................................................................... Chemical Name
1 -Naphthalenecarboxaldehyde 2-Methyl-2-Propenal cMethyl-benzeneaoetaldehyde 2,4-Dihydroxybenzaldehyde 2-Hydroxy-5-nitrobenzaldehyde 

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### :/- Notices

TABLE 6.-ALDEHYDES; REMOVED FROM THEPRIORITY TESTING' 

### LwS--Continued

CAS No. 98-03-3

........................................... 99-72-9
.................................................................................................... 106-2f6-3
.................................................................................................. 106-72-9

................................................................................................. 123-08-0
................................................................................................. 135-02-4

.................................................................................................. 141-27-5
............................................................................................ 143-14-6

.................................................................................................. 455-19-6

................................................................................................. 505-57-7

.................................................................................................. 552-89-6

.................................................................................................. 1121-60-4

................................................................................................ 1200-14-2

................................................................................................ 1334-78-7

................................................................................................ 1423-46-7

.......................................................................................... 5435-64-3

................................................................................................ 5780-07-4

................................................................................................ 5949-05-3

................................................................................................ 5988-91-0

................................................................................................ 10031-82-0

.............................................................................................. 28602-27-9

........................................ 37677-14:-8

....................................................................................... + Chemical Name 2-Thiophenecarboxaldehyde 4-Methylbenzeneacetaldehyde 3,7-Dimethyl-2,6-Octadienal, (Z)- 2,6-Dimethyl-5-heptenal 4-Hydroxybenzaldehyde 2-Methoxybenzaldehyde 3,7-Dimethyl-_2,6-octadienal, '(E)- 9-Undecenal 4-(Trfluoromethyl)benzaldehyde 2-Hexenal 2-Nitrobenzaldehyde 2-Pyndinecarboxaldehyde 4-Butylbenzaldehyde Methylbenzaldehyde 2,4,6-Trimethyl-3-cyclohexene i-carboxaldehyde 3,5,5-Trimethylhexanal 7-Methoxy-1 3-benzodioxole-5-carboxaldehyde 3,7-Dimethyl-6-Octenal, (S)- 3,7-dimethyloctanal 4-Ethoxybenzaldehyde (Dimethylamino)benzaldehyde 4-4-Methyl-3-pentenyl)-3-cycldhexene-l-carboxaldehyde
2. Cyanoacrylates.In -its 28th Report, the ITC recommended a group of 11 cyanoacrylates for physical and chemical property testing. The ITC's recommendation was based on concerns and uncertainties rdlated ,to production and use, potential exposures and -releases from production, processing and use (56 FR 41212, August 19, 1991). -Based on a review of production volume data, the ITC is removig,7 cyanoacrylates fromthe Priority Testing List. These cyanoacrylates
are listed in the following Table 7
TABLE'7 -CYANOACRYLATES REMOVED FROM THE PRIORITY TESTING LIST
GAS No. Chemical Name
1069-55-2

........ 2-Propenoic acid, 2-cyano- isobutyl ester (isobutyl cyanoacrylate) 6606-65-1

........ 2-Propenoic acid, 2-cyano- butyl ester (butyl cyanoacrylate) 7324-02-9

........ 2-Propenoic acid, 2-cyano- 2-propenyl ester (allyl cyanoacrylate) 10586-17-1

...... 2-Propenoic acid, 2-cyano- 1-methylethyl ester (isopropyl cyanoacrylate) 21982-43-4

...... 2-Propenoic acid, 2-cyano- ethoxy ethyl ester (ethoxy ethyl cyanoacrylate) 23023-91-8

...... 2-Propenoic acid, 2-cyano- 2,2,2-tdfluomethylester (2,2,2-trifluoromethylcyanoacrylate) 27B16-23-5
...... I2-Propenoic acid, 2-cyano- methyoxy ethyl ester (methoxy ethylcyanoacrylate)

3. Diarylethers.In its 29th Report, the ecological effects screening tests (56 FR Exercise. Based on areview of ITCrecommended a group of 14.alkyl, 67424, December 30, 1991). This production volume data, theITCis bromo, chloro, orhydroxy-methyl diaryl recommendation was based on an removing 4.diaryl ethers from the ethers for physical chemical property analysis ofdata in SuCCSES that was Priority Testing List. These,diaryl ethers biodegradation rate, health effects and compiled during the ITC's 6th Scoring are listed in the following Table 8.
TABLE 8.-DIARYL ETHERS REMOVED FROM THE PRIORITY TESTING LIST
CAS No. Cherical Name
3061-36-7

............................................................................................................................. 1;4-Diphenoxybenzene 50789-44-1
........................................................................................................................... 3-Phenoxybenzene methanol acetate 61702-88-3

........................................................................................................................... 1,1'-Oxybis(1,1,3,3-tetramethylbutyl)benzene 69834-1 19- 1

........................................................................................................................... 1'-Oxybisdodecylbenzene

References

(1) Walker, J.D. and Brink, R.H. "New CostEffective, Computerized Approaches to Selecting Chemicals for Priority Testing Consideration, In:Aquatic Toxiologyand Environmental Fate:Eleventh Volume, ASTM STP 1007 G. W. Suter, IIand M.A. Lewis, Eds., American Society for Testing and Materials, Philadelphia, PA.pp. 507-536 -(1989)., (2) Walker, J.D. "Chemical Selection by the TSCA Interagency Testing Committee: Use of Computerized Substructure Searching to Identify Chemical Groups forHealth Effects, Chemical Fate and Ecological Effects Testing, Science ofthe TotalEnvironment: Vol. 109/110, pp. 691-700 (1991).

(3) Walker, J.D. "The TSCA Interagency Testing Committee, 1977 to 1992: Creation, Structure, Functions and Contributions, In: EnvironmentalToxicologyandRisk Assessment: Second Volume, ASTM STP 1216, J.W. Gorsuch, F.J. Dwyer, C.G. Ingersoll and T.W. LaPoint, Eds., American Society for Testing and Materials, Philadelphia, PA, pp. 451-509 (1993).
IV The TSCA Section 4(e) Revised Priority Testing List

The revised TSCA section 4(e) Priority Testing List follows. 

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### Federal Register / Vol. 59, No. 249 / Thursday, December 29, 1994 / Notices

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### I November 1988

May 1990
November 1990
November 1990 November 1990 May 1991 May 1991 May 1991 May 1991 November 1991 May 1992 May 1992 January 1993 January 1993 January 1993 May 1993 May 1994 May 1994 May 1994 November 1994 THE TSCA SECTION 4(E) PRIORITY TESTING LIST (NOVEMBER 1994) Chemical/Group Butyraldehyde Tetrakis(2-chloroethyl)ethylene diphosphate Tris(1,3-dichloro-2-propyl) phosphate Tns(1-chloro-2-propyl) phosphate Tris(2-chloro-1-propyl) phosphate Tris(2-chloroethyl)-phosphate 15 Isocyanates

62 Aldehydes Sulfonyl bis(4-chlorobenzene) 17 Chemicals with insufficient subchronic (90-day) toxicity data Acetone Thiophenol m-Dinitrobenzene 14 Cyanoacrylates 10 Alkyl- bromo- chloro- hydroxymethyl diaryl ethers 56 Siloxanes 25 Chloroalkyl phosphates 24 Chemicals with no dermal toxicity data 13 Propylene glycol ethers and esters

- 32 Methyl ethylene glycol ethers and esters 32 Chemicals with insufficient dermal absorption data. White phosphorus Ethyl ter-butyl ether Tert-amyl methyl ether 25 Chemicals with insufficient dermal absorption data Action
Recommended Recommended

ignate

Recommended

ignate Recommended

ignate Recommended Recommended Designated Designated Recommended Recommended Recommended Recommended Recommended Designated Recommended Recommended *Designated Designated Recommended Recommended Designated with intent-to-desintent-to-desintent-to-desTSCA InteragencyTesting Committee

Statutory Organizations and Their Representatives

CouncilonEnvironmentalQuality Elisabeth Blaug, Member DepartmentofCommerce EdwardWhite, Member. Willie E.May, Alternate Environmental Protection Agency David R. Williams, Member Lois Dicker, Alternate NationalCancer Institute Harry Seigried, Member Richard Adamson, Alternate NationalInstituteofEnvironmentalHealth Sciences ErrolZeiger, Member, Vice Chair H.B.Matthews, Alternate NationalInstitute forOccupational Safety andHealth HenrykaNagy, Member David A.Dankovic, Alternate NationalScience Foundation Linda Duguay, Member Occupational SafetyandHealth Administration Christine Whittaker, Member, Chair

Liaison Organizations and Their Representatives

Agencyfor Toxic SubstancesandDisease Registry William Cibulas, Member
ConsumerProductSafety Commission Val Schaeffer, Member Lakshmi C. Mishra, Alternate Department of

Agriculture Donald Derr, Member Clifford Rice, Alternate Departmentof Defense David A. Macys, Member James N. McDougal, Alternate DepartmentoftheInterior Barnett A. Rattner, Member FoodandDrugAdministration Edwin J.Matthews, Member Ralu Kammula, Alternate
National Libraryof Medicine Vera Hudson, Member
NationalToxicologyProgram Victor A. Fung, Member
Counsel Mary Ellen Levine, Office ofGeneral Counsel, EPA

TechnicalSupportContractor Syracuse Research Corporation ITCStaff John D. Walker, Executive Director Norma S.L. Williams, Executive Assistant, TSCA Interagency Testing Committee U.S. EPA/OPPT-(MC 7401) 401 M Street, S.W. Washington, D.C. 20460 Phone (202) 260-1825 Fax (202) 260-7895 Internet walker.)ohnd@epamail.epa.gov (FR Doc. 94-32117 Filed 12-28-94; 8:45 am] BILLING CODE 6560-60-F Report

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