<Page>

                                                                  Exhibit 10.04

                                                                  EXECUTION COPY

     [CONFIDENTIAL TREATMENT REQUESTED] /*/ INDICATES MATERIAL THAT HAS BEEN
OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN REQUESTED. ALL SUCH
OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED.

                                                                    CONFIDENTIAL


                   COLLABORATION, LICENSE AND SUPPLY AGREEMENT

                                     BETWEEN

                                 ACUSPHERE, INC.

                                       AND

                               NYCOMED DANMARK APS

<Page>

                                                                  EXECUTION COPY

                                TABLE OF CONTENTS

<Table>
<Caption>
SECTION                                                                           PAGE NO.
-------                                                                           --------
<S>                                                                                      <C>
ARTICLE I DEFINITIONS....................................................................1
  Section 1.01.   Acceptance for Filing..................................................2
  Section 1.02.   Acusphere Know-How.....................................................2
  Section 1.03.   Acusphere Manufacturing Cost...........................................2
  Section 1.04.   Acusphere Patent Rights................................................2
  Section 1.05.   Acusphere Technology...................................................2
  Section 1.06.   Acusphere Unit Forecast................................................3
  Section 1.07.   Affiliate..............................................................3
  Section 1.08.   Applicable Laws........................................................3
  Section 1.09.   Bulk Packaging Specifications..........................................3
  Section 1.10.   Certificate of Compliance..............................................3
  Section 1.11.   cGMP...................................................................3
  Section 1.12.   CMC Data...............................................................4
  Section 1.13.   CIS Jurisdictions......................................................4
  Section 1.14.   Collaboration..........................................................4
  Section 1.15.   Competent Authorities..................................................4
  Section 1.16.   Competitive Product....................................................4
  Section 1.17.   Confidential Information...............................................4
  Section 1.18.   Control................................................................5
  Section 1.19.   Deemed Acusphere Manufacturing Cost....................................5
  Section 1.20.   Dollars or "$".........................................................5
  Section 1.21.   Dossier................................................................5
  Section 1.22.   EMEA...................................................................5
  Section 1.23.   FDA....................................................................5
  Section 1.24.   Field..................................................................5
  Section 1.25.   Final Packaging Specifications.........................................6
  Section 1.26.   First Commercial Sale..................................................6
  Section 1.27.   GAAP...................................................................6
  Section 1.28.   Good Clinical Practices................................................6
  Section 1.29.   Governmental Approval..................................................6
  Section 1.30.   Imaging Competitor.....................................................6
  Section 1.31.   Improvements...........................................................6
  Section 1.32.   Intellectual Property Strategy.........................................7
  Section 1.33.   Jurisdiction...........................................................7
  Section 1.34.   Know-How...............................................................7
  Section 1.35.   Launch Quantity........................................................7
  Section 1.36.   MAA....................................................................7
  Section 1.37.   Manufacture or Manufacturing Process...................................7
  Section 1.38.   Manufacturing Competitor...............................................7
</Table>

<Page>

<Table>
<S>                                                                                     <C>
  Section 1.39.   Marketing Authorization................................................8
  Section 1.40.   Marks..................................................................8
  Section 1.41.   Minimum Sales Target...................................................8
  Section 1.42.   Net Sales..............................................................8
  Section 1.43.   Out of Pocket Expenses.................................................9
  Section 1.44.   Packaging Specifications...............................................9
  Section 1.45.   Patent Rights.........................................................10
  Section 1.46.   Partner...............................................................10
  Section 1.47.   Phase III Event.......................................................10
  Section 1.48.   Phase IV..............................................................10
  Section 1.49.   Pricing and Reimbursement Approvals...................................10
  Section 1.50.   Primary Jurisdictions.................................................10
  Section 1.51.   Prime Rate of Interest................................................10
  Section 1.52.   Product...............................................................11
  Section 1.53.   Proof of Concept Trial................................................11
  Section 1.54.   Royalty...............................................................11
  Section 1.55.   Royalty Term..........................................................11
  Section 1.56.   Sales Forecast........................................................11
  Section 1.57.   Secondary Jurisdictions...............................................12
  Section 1.58.   Shipment..............................................................12
  Section 1.59.   Specifications........................................................12
  Section 1.60.   Technology Access and Trademark Usage Fee.............................12
  Section 1.61.   Territory.............................................................12
  Section 1.62.   Territory-Specific Manufacturing Costs................................12
  Section 1.63.   Third Party...........................................................12
  Section 1.64.   Unit Forecast.........................................................12
  Section 1.65.   United States.........................................................13
  Section 1.66.   Other Definitions.....................................................13
ARTICLE II COLLABORATION................................................................14
  Section 2.01.   Objectives............................................................14
  Section 2.02.   Coronary Heart Disease Development Program............................14
  Section 2.03.   Commercially reasonable efforts to Commercialize......................16
  Section 2.04.   Commercialization.....................................................16
  Section 2.05.   Availability of Resources; Cooperation................................16
ARTICLE III LICENSE.....................................................................16
  Section 3.01.   License Fee...........................................................16
  Section 3.02.   License Terms.........................................................16
  Section 3.03.   Marks.................................................................20
  Section 3.04.   Ownership of Improvements.............................................20
ARTICLE IV ROYALTY AND MILESTONE PAYMENTS...............................................20
  Section 4.01.   Royalty Payments......................................................20
  Section 4.02.   Technology Access and Trademark Usage Fee.............................21
  Section 4.03.   Milestone Payments....................................................21
  Section 4.04.   Sales Milestone Payments..............................................22
  Section 4.05.   Reports...............................................................22
</Table>

                                       ii
<Page>

<Table>
<S>                                                                                     <C>
ARTICLE V COMMERCIALIZATION.............................................................24
  Section 5.01.   Promotion And Marketing Obligations...................................24
ARTICLE VI MANUFACTURE AND SUPPLY.......................................................27
  Section 6.01.   Agreement to Supply Product...........................................27
  Section 6.02.   Quality Assurance; Changes............................................27
  Section 6.03.   Acusphere's Duties....................................................28
  Section 6.04.   Compliance with Applicable Laws.......................................30
  Section 6.05.   Supply Allocation.....................................................30
  Section 6.06.   Failure to Supply; Manufacturing License..............................31
ARTICLE VII PURCHASE AND SALE...........................................................33
  Section 7.01.   Purchase Price and Payment............................................33
  Section 7.02.   Determination of Deemed Acusphere Manufacturing Cost; Audit...........33
  Section 7.03.   Purchase Forms........................................................35
  Section 7.04.   Confirmation..........................................................35
  Section 7.05.   Delivery..............................................................35
  Section 7.06.   Forecasts and Orders..................................................36
ARTICLE VIII WARRANTY, REJECTION AND INSPECTIONS........................................37
  Section 8.01.   Acusphere Warranty and Shelf-life.....................................37
  Section 8.02.   Rejection of Non-Conforming Product...................................38
  Section 8.03.   Nycomed Inspections...................................................39
ARTICLE IX REGULATORY COMPLIANCE........................................................39
  Section 9.01.   Marketing Authorization Holder........................................39
  Section 9.02.   Compilation of Dossier................................................39
  Section 9.03.   Marketing Authorizations..............................................40
  Section 9.04.   Interaction with Competent Authorities................................40
  Section 9.05.   Adverse Drug Event Reporting and Phase IV Surveillance................40
  Section 9.06.   Commercial Sale; Testing And Reporting................................41
  Section 9.07.   Compliance............................................................41
  Section 9.08.   Quality Agreement.....................................................41
ARTICLE X PATENTS AND TRADEMARKS........................................................42
  Section 10.01.  Maintenance and Improvement of Patents and Marks......................42
  Section 10.02.  Prosecution of Infringement...........................................42
ARTICLE XI CONFIDENTIALITY..............................................................43
  Section 11.01.  Confidentiality.......................................................43
  Section 11.02.  Disclosure of Agreement...............................................44
ARTICLE XII ACUSPHERE'S OPTION TO MARKET THE PRODUCT UNDER CERTAIN CIRCUMSTANCES........44
  Section 12.01.  Co-Marketing Rights...................................................44
ARTICLE XIII REPRESENTATIONS AND WARRANTIES.............................................45
  Section 13.01.  Corporate Power.......................................................45
  Section 13.02.  Due Authorization.....................................................45
  Section 13.03.  Binding Obligation....................................................45
  Section 13.04.  Legal Proceedings.....................................................45
  Section 13.05.  Absence of Certain Changes............................................46
  Section 13.06.  Limitation of Liability...............................................46
</Table>

                                       iii
<Page>

<Table>
<S>                                                                                    <C>
ARTICLE XIV INDEMNIFICATION.............................................................46
  Section 14.01.  Intellectual Property Indemnity.......................................46
  Section 14.02.  Product Liability and Insurance.......................................47
ARTICLE XV COVENANTS....................................................................48
  Section 15.01.  Covenant Not To Launch Competitive Product............................48
  Section 15.02.  Limitation to the Territory...........................................48
  Section 15.03.  Marketing Commitment..................................................48
ARTICLE XVI PRODUCT RECALL..............................................................49
  Section 16.01.  Product Recalls or Withdrawal.........................................49
  Section 16.02.  Recall Costs..........................................................49
  Section 16.03.  Notification of Complaints............................................50
  Section 16.04.  Notification of Threatened Action.....................................50
ARTICLE XVII INSURANCE..................................................................50
  Section 17.01.  Insurance.............................................................50
ARTICLE XVIII TERM; DEFAULT AND TERMINATION.............................................51
  Section 18.01.  Term..................................................................51
  Section 18.02.  Basis for Termination by Either Party.................................51
  Section 18.03.  Basis for Termination by Nycomed......................................51
  Section 18.04.  Basis for Termination by Acusphere....................................52
  Section 18.05.  Remedies..............................................................52
  Section 18.06.  Effect of Termination by Nycomed......................................53
  Section 18.07.  Effect of Termination by Acusphere....................................54
  Section 18.08.  License Following Expiration..........................................55
ARTICLE XIX MISCELLANEOUS...............................................................55
  Section 19.01.  No-Solicitation.......................................................55
  Section 19.02.  Assignment............................................................56
  Section 19.03.  Force Majeure.........................................................56
  Section 19.04.  Governing Law; Dispute Resolution.....................................57
  Section 19.05.  Waiver................................................................57
  Section 19.06.  Severability..........................................................58
  Section 19.07.  Notices...............................................................58
  Section 19.08.  Independent Contractors...............................................59
  Section 19.09.  Rules of Construction.................................................59
  Section 19.10.  Publicity and Publications............................................59
  Section 19.11.  Entire Agreement; Amendment...........................................60
  Section 19.12.  Headings..............................................................60
  Section 19.13.  Counterparts..........................................................60

Exhibit A - Acusphere European Patent Rights...........................................A-1
Exhibit B - Form of Certificate of Compliance..........................................B-1
Exhibit C - U.S. Development Program...................................................C-1
Exhibit D-1 Form of Acusphere Press Release............................................D-1
Exhibit D-2 Form of Nycomed Press Release..............................................D-2
</Table>

                                       iv
<Page>

                                                                  EXECUTION COPY

                   COLLABORATION, LICENSE AND SUPPLY AGREEMENT

     This Collaboration, License and Supply Agreement (the "Agreement") is made
as of July 6, 2004 (the "Effective Date") by and between Acusphere, Inc., a
Delaware corporation having offices at 500 Arsenal Street, Watertown, MA, 02472,
USA, ("Acusphere"), and Nycomed Danmark ApS, a Danish corporation having offices
at Langebjerg 1, Roskilde 4000, Denmark ("Nycomed"). Acusphere and Nycomed are
sometimes referred to collectively herein as the "Parties" or singly as a
"Party."

                                 R E C I T A L S

     WHEREAS, Acusphere possesses proprietary drug delivery systems based on
porous microparticles, including "AI-700", a medical product being developed by
Acusphere as an ultrasound contrast agent, initially for use in the evaluation
of coronary heart disease (hereinafter the "Product", as more fully defined
below), and has substantial experience and expertise in the discovery, design
and development of products based on these proprietary drug delivery systems for
medical applications;

     WHEREAS, Nycomed possesses substantial resources and expertise in the
development of pharmaceutical products and intends to invest resources for the
commercialization and marketing of the Product under this Agreement;

     WHEREAS, Acusphere is the owner of certain patents related to the Product
and intends to maintain such patents as set forth herein;

     WHEREAS, Acusphere wishes to grant to Nycomed, and Nycomed wishes to obtain
from Acusphere, an exclusive license under the Acusphere Technology to market,
advertise, promote, distribute, offer for sale, sell and import, the Product in
the Territory for use in the Field on the terms and subject to the conditions
set forth herein; and

     WHEREAS, Nycomed wishes Acusphere to manufacture and Acusphere desires to
manufacture the Product to be sold in the Territory by Nycomed.

     NOW, THEREFORE, in consideration of the foregoing recitals and the mutual
covenants and agreements contained herein, the Parties hereto, intending to be
legally bound, do hereby agree as follows:

                                    AGREEMENT

                                    ARTICLE I

                                   DEFINITIONS

     The following terms as used in this Agreement shall have the meaning set
forth below:

<Page>

     Section 1.01. ACCEPTANCE FOR FILING

     "ACCEPTANCE FOR FILING" means Nycomed's receipt of a letter issued by the
EMEA or other Competent Authority indicating acceptance for filing of a
regulatory dossier pursuant to Applicable Laws in the Territory.

     Section 1.02. ACUSPHERE KNOW-HOW

     "ACUSPHERE KNOW-HOW" means any and all Know-How related to the Product,
including Acusphere's proprietary drug delivery system based on porous
microparticles and which is under the Control of Acusphere as of the Effective
Date, or is created by Acusphere during the term of this Agreement including,
but not limited to, data and documentation of clinical trials and useful for
clinical trials created outside the Territory as of the Effective Date and
during the term of this Agreement, which is not covered by the Acusphere Patent
Rights, but is necessary or useful to develop, Manufacture and commercialize the
Product in the Territory for use in the Field.

     Section 1.03. ACUSPHERE MANUFACTURING COST

     "ACUSPHERE MANUFACTURING COST" means the actual cost of the Manufacture by
Acusphere of the Product under the Manufacturing Process, including the related
quality assurance and quality control activities as required by Applicable Laws,
which actual cost shall be comprised of the cost of goods produced as recorded
in accordance with GAAP, and shall include direct labor and direct material,
including raw materials and packaging materials, and the allocable portion of
the overhead of Acusphere attributable to the Manufacture of the Product.
Acusphere Manufacturing Cost shall exclude (i) Territory Specific Manufacturing
Costs, (ii) selling and research and development expenses and general and
administrative expenses associated with selling and research and development or
other functions other than manufacturing of the Product; and (iii) those
components of the actual cost of the Manufacture by Acusphere of the Product
under the Manufacturing Process that may be identified from time to time as
being associated solely with Product manufactured for sale outside the
Territory, plus the allocable portion of the manufacturing overhead of Acusphere
directly attributable thereto. Direct labor costs shall include the cost of all
compensation paid to applicable employees, as well as the cost of all fringe
benefits and administrative costs associated with the management and payment of
these employees; however, such costs shall not include the non-cash costs
associated with incentive stock options granted to employees.

     Section 1.04. ACUSPHERE PATENT RIGHTS

     "ACUSPHERE PATENT RIGHTS" means any and all Patent Rights related to the
Product, including Acusphere's proprietary drug delivery system as of the
Effective Date and at any time during the Term of this Agreement, which are
necessary or appropriate to develop, Manufacture and commercialize the Product
in the Territory for use in the Field, which are under the Control of Acusphere
as of the Effective Date or during the Term, as the case may be, as well as
Improvements thereto developed during the Term. The Acusphere Patent Rights as
of the Effective Date are set forth on Exhibit A, subject to amendment as
provided in Section 10.01 hereof.

     Section 1.05. ACUSPHERE TECHNOLOGY

                                        2
<Page>

     "ACUSPHERE TECHNOLOGY" means the Acusphere Patent Rights, the Acusphere
Know-How, and the Improvements.

     Section 1.06. ACUSPHERE UNIT FORECAST

     "ACUSPHERE UNIT FORECAST" means the forecast covering projected needs of
AI-700 during the first [CONFIDENTIAL TREATMENT REQUESTED] /*/ of
requirements of AI-700 of Acusphere and all other customers of Acusphere
outside the Territory, on an annual basis, which has been submitted by
Acusphere to Nycomed prior to the execution of this Agreement.

     Section 1.07. AFFILIATE

     "AFFILIATE" means an individual, trust, business trust, joint venture,
partnership, corporation, association or any other entity which owns, is owned
by or is under common ownership with, a Party. For the purposes of this
definition, the term "owns" (including, with correlative meanings, the terms
"owned by" and "under common ownership with") as used with respect to any Party,
shall mean the possession (directly or indirectly) of more than 50% of the
outstanding voting securities of a corporation or comparable equity interest in
any other type of entity.

     Section 1.08. APPLICABLE LAWS

     "APPLICABLE LAWS" means all applicable laws, rules, regulations and
guidelines that may apply to the development, marketing, manufacturing,
packaging or sale of the Product in the Territory or the performance of either
Party's obligations under this Agreement including laws, regulations and
guidelines governing the import, export, development, marketing, distribution
and sale of the Product in the Territory, to the extent applicable and relevant,
and including all Marketing Authorizations in each Jurisdiction, all cGMP or
Good Clinical Practices standards or guidelines promulgated by the FDA, the EMEA
or other Competent Authorities and including trade association guidelines, where
applicable, as well as United States' export control laws and the United States'
Foreign Corrupt Practices Act.

     Section 1.09. BULK PACKAGING SPECIFICATIONS

     "BULK PACKAGING SPECIFICATIONS" means the packaging specifications and the
labeling specifications necessary for the transfer of vials of Product from
Acusphere to Nycomed, as mutually determined by Acusphere and Nycomed from time
to time, and in compliance with Applicable Laws.

     Section 1.10. CERTIFICATE OF COMPLIANCE

     "CERTIFICATE OF COMPLIANCE" means the certificate of compliance in the form
attached hereto as Exhibit B.

     Section 1.11. cGMP

     "cGMP" means current good manufacturing practices as defined in 21 Code of
Federal Regulations part 210 and 211.

                                        3
<Page>

     Section 1.12. CMC DATA

     "CMC DATA" shall mean those data required by Annex I to Directive
2001/83/EC including the qualitative and quantitative particulars of the
constituents, stability testing, the description of the manufacturing method and
the controls and tests carried out at all relevant stages of the Manufacturing
Process.

     Section 1.13. CIS JURISDICTIONS

     "CIS Jurisdictions' means Armenia, Azerbaijan, Belarus, Georgia,
Kazakhstan, Kyrgyzstan, Republic of Moldova, Russian Federation, Tadzhikistan,
Turkmenistan, Ukraine and Uzbekistan.

     Section 1.14. COLLABORATION

     "COLLABORATION" means the activities of the Parties carried out in
performance of, and the relationship between the Parties established by, this
Agreement.

     Section 1.15. COMPETENT AUTHORITIES

     "COMPETENT AUTHORITIES" means collectively the governmental entities in
each country, or recognized regional authorities, in the Territory responsible
for the regulation of and/or the reimbursement of medicinal products intended
for human use.

     Section 1.16. COMPETITIVE PRODUCT

     "COMPETITIVE PRODUCT" means any ultrasound contrast agent and any
radioisotope product which could be substituted in full or in part for the
Product for use in the Field in the Territory; provided that: (i) the product
as set forth to Acusphere by Nycomed prior to the execution of the Agreement
shall not be considered a Competitive Product if sold by Nycomed or an
Affiliate of Nycomed in the CIS Jurisdictions only, pursuant to an existing
agreement or a renewal thereof; (ii) a product shall not be considered a
Competitive Product with respect to any Jurisdiction unless its gross sales
in such Jurisdiction over the most recent calendar quarter equaled at least
[CONFIDENTIAL TREATMENT REQUESTED] /*/ % of the amount of gross Product sales
in such Jurisdiction by Nycomed and its Affiliates during such calendar
quarter; and (iii) a product shall not be considered a Competitive Product
with respect to the Territory as a whole unless its gross sales in the
Territory as a whole over the most recent twelve months equaled at least the
lesser of: (A) [CONFIDENTIAL TREATMENT REQUESTED] /*/ % of the amount of gross
Product sales in the Territory as a whole by Nycomed, its Affiliates and
Partners during such twelve month period: or (B) [CONFIDENTIAL TREATMENT
REQUESTED] /*/ % of the amount of gross Product sales in any Primary
Jurisdiction by Nycomed, its Affiliates and Partners during such twelve
month period.

     Section 1.17. CONFIDENTIAL INFORMATION

     "CONFIDENTIAL INFORMATION" means any confidential or proprietary
information of a Party, whether in oral, written, graphic or electronic form,
marked as confidential (or, if delivered orally, confirmed in writing within
thirty (30) days of the date of disclosure). Confidential

                                        4
<Page>

Information shall not include any information which the receiving Party can
prove by competent evidence:

          (a) is now, or hereafter becomes, through no act or failure to act on
     the part of the receiving Party, generally known or available;

          (b) is known by the receiving Party at the time of receiving such
     information, as evidenced by its written records maintained in the ordinary
     course of business;

          (c) is hereafter furnished to the receiving Party by a Third Party, as
     a matter of right and without restriction on disclosure;

          (d) is independently developed by the receiving Party, as evidenced by
     its written records, without knowledge of, and without the aid, application
     or use of, the disclosing Party's Confidential Information; or

          (e) is the subject of a written permission to disclose provided by the
     disclosing Party.

     Section 1.18. CONTROL

     "CONTROL" means the possession of the ability to grant a license or
sublicense as provided for herein without violating the terms of any agreement.

     Section 1.19. DEEMED ACUSPHERE MANUFACTURING COST

     "DEEMED ACUSPHERE MANUFACTURING COST" shall be as determined pursuant
Section 7.02.

     Section 1.20. DOLLARS OR "$"

     "DOLLARS" OR "$" means United States Dollars.

     Section 1.21. DOSSIER

     "DOSSIER" means the master regulatory dossier relating to the Product in
connection with obtaining a Marketing Authorization for such Product in the
Territory, including relevant non-clinical and clinical data and the CMC Data.

     Section 1.22. EMEA

     "EMEA" means the European Medicine Evaluation Agency.

     Section 1.23. FDA

     "FDA" means the United States Food and Drug Administration.

     Section 1.24. FIELD

                                        5
<Page>

     "FIELD" means (i) the evaluation of coronary heart disease and (ii) other
medical applications of the Product to the extent provided in Section 3.02 (e)
hereof.

     Section 1.25. FINAL PACKAGING SPECIFICATIONS

     "FINAL PACKAGING SPECIFICATIONS" means the packaging specifications and the
labeling specifications necessary for the resale of Product by Nycomed, its
Affiliates or Partners within the Territory, as determined by Nycomed in
consultation with Acusphere from time to time, and in compliance with Applicable
Laws.

     Section 1.26. FIRST COMMERCIAL SALE

     "FIRST COMMERCIAL SALE" means (i) with respect to a Jurisdiction, the first
sale for use, consumption or resale of Product by Nycomed in such Jurisdiction
and (ii) with respect to the Territory, the First Commercial Sale in any
Jurisdiction, in each case excluding so-called "named patient" sales prior to
Marketing Authorization. A sale to an Affiliate shall not constitute a First
Commercial Sale unless the Affiliate is the end user of the Product. For
avoidance of doubt, the provision of free samples of the Product shall not be
construed to constitute a sale of the Product for purposes of this definition.

     Section 1.27. GAAP

     "GAAP" means United States generally accepted accounting principles
consistently applied throughout the periods indicated.

     Section 1.28. GOOD CLINICAL PRACTICES

     "GOOD CLINICAL PRACTICES" means current good clinical practices as defined
in 21 Code of Federal Regulations part 50 et seq. and part 312 et seq.

     Section 1.29. GOVERNMENTAL APPROVAL

     "GOVERNMENTAL APPROVAL" means all permits, licenses and authorizations,
including but not limited to, import permits and Marketing Authorizations,
required by any Competent Authority as a prerequisite to the Manufacturing,
packaging, distribution, marketing or selling of the Product, as well as Pricing
and Reimbursement Approvals.

     Section 1.30. IMAGING COMPETITOR

     "IMAGING COMPETITOR" means those competitors of Acusphere in the diagnostic
imaging business disclosed in writing by Acusphere to Nycomed prior to the
Effective Date.

     Section 1.31. IMPROVEMENTS

     "IMPROVEMENTS" means any and all developments, inventions or discoveries in
the Field relating to the Acusphere Technology, including patentable inventions,
developed, or acquired by Acusphere or by Nycomed or both Parties jointly, as
the case may be, pursuant to activities

                                        6
<Page>

carried out under this Agreement at any time during the Term and shall include,
but not be limited to, developments intended to enhance the safety and/or
efficacy of the Product.

     Section 1.32. INTELLECTUAL PROPERTY STRATEGY

     "INTELLECTUAL PROPERTY STRATEGY" means the patent strategy setting forth
activities related to the Acusphere Patent Rights agreed upon in writing by the
Steering Committee at its first meeting after the date hereof, as the same may
be amended from time to time by unanimous consent of all members of the Steering
Committee.

     Section 1.33. JURISDICTION

     "JURISDICTION" means a country within the Territory.

     Section 1.34. KNOW-HOW

     "KNOW-HOW" means all results, know-how, trade secrets, inventions, data,
processes, techniques, procedures, compositions, devices, methods, formulas,
protocols and information in any tangible or intangible form whatsoever, whether
or not patentable, which relate to the Product or the Manufacture of the Product
and which are not generally publicly known, including, without limitation, all
chemical, biochemical, toxicological, and scientific research information,
whether in written, graphic or video form or any other form or format.

     Section 1.35. LAUNCH QUANTITY

     "LAUNCH QUANTITY" means a quantity of Product adequate to meet the
requirements set forth for the first three (3) months in the Updated Unit
Forecast.

     Section 1.36. MAA

     "MAA" means a Marketing Authorization Application, filed or to be filed,
with the EMEA or other Competent Authority seeking authorization and approval to
place Product on the market in the Territory.

     Section 1.37. MANUFACTURE OR MANUFACTURING PROCESS

     "MANUFACTURE" or "MANUFACTURING PROCESS" means the storage, analysis,
handling, production, processing and packaging of a Product, in accordance with
this Agreement and Applicable Laws.

     Section 1.38. MANUFACTURING COMPETITOR

     "MANUFACTURING COMPETITOR" means those competitors of Acusphere in the
imaging, drug delivery or specialty pharmaceuticals business as disclosed in
writing by Acusphere to Nycomed prior to the Effective Date.

                                        7
<Page>

     Section 1.39. MARKETING AUTHORIZATION

     "MARKETING AUTHORIZATION" means all necessary and appropriate regulatory
approvals, including but not limited to, variations thereto, to place the
Product on the market in a particular Jurisdiction.

     Section 1.40. MARKS

     "MARKS" means any trademark, logo, design or trade dress owned by Acusphere
or any additional trademark, logo, design or trade dress owned and proposed by
Acusphere and approved by Nycomed for use in connection with the marketing and
sale of the Product in the Territory, whether registered or not.

     Section 1.41. MINIMUM SALES TARGET

     "MINIMUM SALES TARGET," as used in Section 12.01 hereof, means, with
respect to each of the [CONFIDENTIAL TREATMENT REQUESTED] /*/ following the
First Commercial Sale of Product in a Jurisdiction, at least [CONFIDENTIAL
TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL TREATMENT REQUESTED] /*/ %) of
the [CONFIDENTIAL TREATMENT REQUESTED] /*/ for such Jurisdiction [CONFIDENTIAL
TREATMENT REQUESTED] /*/, with respect to the [CONFIDENTIAL TREATMENT
REQUESTED] /*/ following First Commercial Sale of Product in a Jurisdiction,
at least [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL TREATMENT
REQUESTED] /*/ %) of the [CONFIDENTIAL TREATMENT REQUESTED] /*/ for such year
[CONFIDENTIAL TREATMENT REQUESTED] /*/, and for the [CONFIDENTIAL TREATMENT
REQUESTED] /*/ following the First Commercial Sale of Product in a Jurisdiction,
at least [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL TREATMENT
REQUESTED] /*/ %) of the [CONFIDENTIAL TREATMENT REQUESTED] /*/.

     Section 1.42. NET SALES

     "NET SALES" means the total invoice amount of sales of the Product by
Nycomed or its Affiliates to any Third Party, after deduction of all the
following to the extent applicable to such sales:

        (i)    all trade, case and quantity credits, discounts, refunds or
               rebates actually paid in respect of such sales in amounts
               customary in the trade and (except for rebates required by a
               Competent Authority) not in excess of 5%, including without
               limitation rebates paid to assistance programs and any other
               price reductions required by a governmental agency or Applicable
               Laws;

        (ii)   allowances or credits for returns, including without limitation
               amounts received for sales which become the subject of a
               subsequent temporary or partial recall by a regulatory agency for
               safety or efficacy reasons outside the control of Nycomed, and
               retroactive price reductions (including managed care and similar
               types of rebates), provided that any such price reductions or
               rebates are taken within 12 months of the initial sale to which
               they relate;

                                        8
<Page>

        (iii)  cost of freight, postage and freight insurance to the extent
               shown on the invoice to the Third Party;

        (iv)   sales taxes, value added taxes, excise taxes, and customs duties;
               and

        (v)    cost to Nycomed of export licenses and any taxes (excluding
               income taxes or similar taxes), fees or other charges associated
               with the exportation or importation of Products.

     A sale or transfer to an Affiliate of Nycomed for re-sale by such Affiliate
shall not be considered a sale for the purpose of this provision but the resale
by such Affiliate shall be a sale for such purposes.

     In the event Nycomed or Affiliates transfers Product to a Third Party in a
bona fide arm's length transaction, for consideration, in whole or in part,
other than cash or to a Third Party in other than a bona fide arm's length
transaction, the Net Sales price for such Product shall be deemed to be the
standard invoice price then being invoiced by such entity in a bona fide arms
length transaction with similar customers for the Product

     In the event Nycomed or Affiliates sell Product as part of a bundle with
another product, Net Sales with respect to such sales shall be calculated as if
such Product was sold separately at the average price per vial for Product sold
separately during the calendar quarter of such bundled sale; provided that if
Nycomed, its Partners or Affiliates have not sold Product other than in a bundle
during such calendar quarter, then Net Sales shall be calculated assuming that
the Product was sold at a price per vial equal to the price per vial charged
when selling Product outside the Territory, unless Nycomed can otherwise justify
to Acusphere's reasonable satisfaction another calculation of Net Sales.

     Nothing in the definition of "Net Sales" shall be construed to preclude
Nycomed from granting any and all trade, case and quantity credits, discounts,
refunds or rebates in any amounts it deems necessary or appropriate.

     Section 1.43. OUT OF POCKET EXPENSES

          "OUT OF POCKET EXPENSES" means amounts, up to an aggregate maximum of
$[CONFIDENTIAL TREATMENT REQUESTED] /*/, actually expended by Nycomed in
preparation for marketing the Product in the Territory, consisting of (i) the
cost of any required Phase III trial of the Product (up to a maximum of
$[CONFIDENTIAL TREATMENT REQUESTED] /*/), (ii) the cost of any Phase IV trial of
the Product (up to a maximum of $[CONFIDENTIAL TREATMENT REQUESTED] /*/), and
(iii) other such costs (including for example the cost of market research
reports and regulatory applications) up to a maximum in the aggregate of
$ [CONFIDENTIAL TREATMENT REQUESTED] /*/.

     Section 1.44. PACKAGING SPECIFICATIONS

     "PACKAGING SPECIFICATIONS" means the Bulk Packaging Specifications and the
Final Packaging Specifications.

                                        9
<Page>

     Section 1.45. PATENT RIGHTS

     "PATENT RIGHTS" means all rights under patents and patent applications, and
any and all patents issuing there from (including utility model and design
patents and certificates of invention), together with any and all substitutions,
extensions (including supplementary protection certificates), registrations,
confirmations, reissues, divisionals, continuations, continuations-in-part,
re-examinations, renewals and foreign counterparts of the foregoing, and all
improvements, supplements, modifications or additions.

     Section 1.46. PARTNER

     "PARTNER" means a firm or entity with a direct contractual relationship
with Nycomed or any of its Affiliates, which contractual relationship provides
for the Partner to market, sell or distribute Product. Such term shall include,
but not be limited to, parties receiving sublicenses from Nycomed under Section
3.02 or 6.06 hereof.

     Section 1.47. PHASE III EVENT

     "PHASE III EVENT" means if [CONFIDENTIAL TREATMENT REQUESTED] /*/% or more
of the total images derived from enrollment to date in Acusphere's current Phase
III clinical trials are unevaluable because of the quality of the Product used.
Unevaluable shall mean hereunder images [CONFIDENTIAL TREATMENT REQUESTED] /*/.

     Section 1.48. PHASE IV

     "PHASE IV" means, as applicable, a study or program designed to obtain
additional safety or efficacy data, detect new uses for or abuses of a drug, or
to determine effectiveness for labeled indications under conditions of
widespread usage, which is commenced after a Marketing Authorization for Product
is obtained; provided that for purposes of this Agreement certain Phase IV
studies may commence prior to a Marketing Authorization for the Product being
obtained.

     Section 1.49. PRICING AND REIMBURSEMENT APPROVALS

     "PRICING AND REIMBURSEMENT APPROVALS" means any pricing and reimbursement
approvals which must be obtained before placing Product on the market in any
Jurisdiction in which such approval is required or deemed necessary by Nycomed
in its reasonable discretion.

     Section 1.50. PRIMARY JURISDICTIONS

     "PRIMARY JURISDICTIONS" means France, Germany, the United Kingdom, Spain,
and Italy.

     Section 1.51. PRIME RATE OF INTEREST

     "PRIME RATE OF INTEREST" means the prime rate of interest published from
time to time by the European Banking Federation as Euribor (Euro Interbank
Offered Rate) for the relevant period. The rates are published at
(www.euribor.org).

                                       10
<Page>

     Section 1.52. PRODUCT

     "PRODUCT" means AI-700, a medical product under development by Acusphere,
initially as an ultrasound contrast agent for use in the evaluation of coronary
disease, currently comprised of a sterile, lyophilized powder in glass vials for
individual usage, in the form ultimately approved for sale in the Territory and
as further described in the Specifications, and all formulations, line
extensions and package configurations of the foregoing.

     Section 1.53. PROOF OF CONCEPT TRIAL

     "Proof of Concept Trial" means a clinical trial of the Product in patients
or healthy volunteers that demonstrates efficacy on a preliminary basis and
therefore justifies proceeding with Phase II or Phase III clinical trials of the
Product in a Secondary Indication.

     Section 1.54. ROYALTY

     "ROYALTY" means the royalty to be paid by Nycomed to Acusphere as set forth
in Section 4.01.

     Section 1.55. ROYALTY TERM

     "ROYALTY TERM" means with respect to each Jurisdiction, the period of time
commencing on the First Commercial Sale of Product in such Jurisdiction and
ending on the abandonment, lapse or expiration of the last to expire of the
Acusphere Patent Rights covering the Product; provided that the Royalty Term
with respect to a Jurisdiction will terminate in the event that all Acusphere
Patent Rights covering the Product in such Jurisdiction are found invalid by a
final and non-appealable order of a court of competent jurisdiction.
Notwithstanding the foregoing, the Royalty Term with respect to Secondary
Jurisdictions in which no Patent Rights cover the Product shall begin on First
Commercial Sale of Product in such Jurisdiction and shall end on the earlier to
occur of (i) the date the Royalty Term ends in the last Primary Jurisdiction, or
(ii) entry into such Secondary Jurisdiction of a Competitive Product that would
be covered by Acusphere Patent Rights if marketed in a Primary Jurisdiction,
which results in at least a [CONFIDENTIAL TREATMENT REQUESTED] /*/% reduction in
Net Sales in such Jurisdiction on average over a [CONFIDENTIAL TREATMENT
REQUESTED] /*/ period, when compared to the average monthly Net Sales in such
Jurisdiction over the previous [CONFIDENTIAL TREATMENT REQUESTED] /*/, provided
that Nycomed has not materially reduced the amount of support for the sales and
marketing of the Product in such Jurisdiction.

     Section 1.56. SALES FORECAST

     "SALES FORECAST" means the sales forecast covering the first [CONFIDENTIAL
TREATMENT REQUESTED] /*/ of Product sales in the Territory (beginning, as to
each Jurisdiction, on the First Commercial Sale of the Product in such
Jurisdiction), which has been submitted by Nycomed to Acusphere prior to the
execution of this Agreement, as amended by an updated sales forecast which may
be submitted by Nycomed to Acusphere no later than six months following
submission of the MAA or other applicable regulatory filing and subject to
update and approval by the Steering Committee if substantial changes in market
conditions occur.

                                       11
<Page>

     Section 1.57. SECONDARY JURISDICTIONS

     "SECONDARY JURISDICTIONS" means all Jurisdictions that are not Primary
Jurisdictions.

     Section 1.58. SHIPMENT

     "SHIPMENT" means each individual group of Product received by Nycomed from
Acusphere.

     Section 1.59. SPECIFICATIONS

     "SPECIFICATIONS" means the specifications for the Product as approved by
the FDA and any other Competent Authority, as may be amended in accordance with
the Section 6.02. The initial specifications shall be those provided in writing
by Acusphere to Nycomed prior to the date hereof.

     Section 1.60. TECHNOLOGY ACCESS AND TRADEMARK USAGE FEE

     "TECHNOLOGY ACCESS AND TRADEMARK USAGE FEE" means an amount corresponding
to [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL TREATMENT
REQUESTED] /*/%) of Net Sales of Product.

     Section 1.61. TERRITORY

     "TERRITORY" means Albania, Andorra, Armenia, Austria, Azerbaijan, Belarus,
Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic,
Denmark, Estonia, Finland, France, Georgia, Germany, Greece, Hungary, Iceland,
Ireland, Italy, Kazakhstan, Kyrgyzstan, Latvia, Liechtenstein, Lithuania,
Luxembourg, Malta, Monaco, Netherlands, Norway, Poland, Portugal, Republic of
Moldova, Romania, Russian Federation, Slovakia, Slovenia, Spain, Sweden,
Switzerland, The former Yugoslav Republic of Macedonia, Turkey, Tadzhikistan,
Turkmenistan, Ukraine, Uzbekistan, United Kingdom and Yugoslavia.

     Section 1.62. TERRITORY-SPECIFIC MANUFACTURING COSTS

     "TERRITORY-SPECIFIC MANUFACTURING COSTS" means those components of the
actual cost of the Manufacture by Acusphere of the Product under the
Manufacturing Process that may be identified from time to time as being
associated solely with Product manufactured for sale within the Territory, plus
the allocable portion of the manufacturing overhead of Acusphere directly
attributable thereto.

     Section 1.63. THIRD PARTY

     "THIRD PARTY" means any entity other than: Acusphere, Nycomed, or any
Affiliate of Acusphere or Nycomed.

     Section 1.64. UNIT FORECAST

     "UNIT FORECAST" means the forecast covering projected purchases of Product
by Nycomed

                                       12
<Page>

from Acusphere during the [CONFIDENTIAL TREATMENT REQUESTED] /*/ of Product
sales in the Territory, on a month-to-month basis, which has been submitted by
Nycomed to Acusphere prior to the execution of this Agreement, and as amended by
an updated unit forecast which may be submitted by Nycomed to Acusphere no later
than six months following submission of the MAA or other applicable regulatory
filing. Such updated unit forecast (hereinafter, the "Updated Unit Forecast")
shall provide for aggregate requirements of Product that are no less than
[CONFIDENTIAL TREATMENT REQUESTED] /*/ % of and no greater than [CONFIDENTIAL
TREATMENT REQUESTED] /*/% of those set forth in the Unit Forecast submitted by
Nycomed to Acusphere prior to the execution of this Agreement, taking into
account Nycomed's good faith estimates of what will be required on a monthly
basis as well as the maximum supply capacities of Acusphere on a monthly basis.

     Section 1.65. UNITED STATES

     "UNITED STATES" means the United States of America, its territories and
possessions.

     Section 1.66. OTHER DEFINITIONS

          Each of the following terms is defined in the Section set forth
opposite such term below:

<Table>
          <S>                                                 <C>
          Agreement....................................................Preamble
          Acusphere....................................................Preamble
          Binding Purchase Order................................Section 7.06(c)
          Capacity Increase Notice..............................Section 6.05(c)
          Clinical Documentation................................Section 2.02(c)
          Company Sale Transaction................................Section 19.02
          Data.................................................Section 9.02 (a)
          Effective Date...............................................Preamble
          European Development Program..........................Section 2.02(b)
          Failure of Supply.....................................Section 6.06(c)
          Firm Order...............................................Section 7.07
          Force Majeure...........................................Section 19.03
          Good Reason.............................................Section 12.01
          Initiating Group........................................Section 19.01
          License..................................................Section 3.02
          Losses..............................................Section 14.02 (a)
          NDA...................................................Section 9.02(a)
          Non-Conforming Products..................................Section 8.01
          Nycomed......................................................Preamble
          Other Group.............................................Section 19.01
          Parties......................................................Preamble
          Party........................................................Preamble
          Primary Indication....................................Section 3.02(e)
          Projected Capacity....................................Section 6.05(c)
          Purchase Price...........................................Section 7.01
          Reasonable Cause......................................Section 3.02(d)
</Table>

                                       13
<Page>

<Table>
          <S>                                                   <C>
          Recall..................................................Section 16.01
          Results...............................................Section 2.02(c)
          Royalty Statement.....................................Section 4.05(a)
          Secondary Indication..................................Section 3.02(e)
          Steering Committee....................................Section 5.01(e)
          Term....................................................Section 18.01
          Updated Unit Forecast....................................Section 1.64
          U.S. Development Program..............................Section 2.02(a)
</Table>

                                   ARTICLE II

                                  COLLABORATION

     Section 2.01. OBJECTIVES.

     Pursuant to the European Development Program and/or the U.S. Development
Program, as applicable, Acusphere and Nycomed shall conduct activities using the
Acusphere Technology to develop the Product for use in the Field in the
Territory.

     Section 2.02. CORONARY HEART DISEASE DEVELOPMENT PROGRAM.

          (a) U.S. DEVELOPMENT PROGRAM. Acusphere shall conduct research and
     development of the Product for the Primary Indication for the U.S. market
     at its own cost and expense, subject to the payment of certain expenses by
     Nycomed as set forth herein, pursuant to a written development program (the
     "U.S. Development Program"), a copy of which is attached hereto as Exhibit
     C. In conducting the U.S. Development Program, Acusphere agrees to use all
     commercially reasonable efforts to obtain Marketing Authorization within
     the United States. As its contribution to such program, and in partial
     consideration of the rights granted to Nycomed hereunder, Nycomed shall pay
     Acusphere $8 million, in eight consecutive non-refundable (except as
     otherwise provided in this Agreement), quarterly installments of
     $1 million, commencing three business days after the Effective Date.
     During the course of its current Phase III trial of the Product, Acusphere
     shall continue its practice of quality review of ultrasound images as they
     are produced in the trial, and Nycomed shall, at reasonable intervals and
     on reasonable notice, be entitled to audit the results of such review for
    the sole purpose of reviewing the technical quality of the images.

          (b) EUROPEAN DEVELOPMENT PROGRAM FOR THE PRIMARY INDICATION.

                   (i)     If additional clinical trials or additional tests are
            required by Competent Authorities to market the Product for the
            Primary Indication in the Territory or to establish reimbursement
            prices and such clinical trials or additional tests are not required
            outside the Territory, then the Parties shall discuss the design of
            such clinical trials and tests and Nycomed shall conduct such
            clinical trials and tests at Nycomed's sole cost and expense for the
            Territory. Acusphere shall provide Nycomed with reasonable telephone
            and administrative support in such clinical trials and tests, and
            shall supply to

                                       14
<Page>

            Nycomed reasonable amounts of the Product necessary for such
            additional clinical trials and tests (up to [CONFIDENTIAL TREATMENT
            REQUESTED] /*/ vials) free of charge; provided that if Nycomed
            requires any such clinical trial materials prior to [CONFIDENTIAL
            TREATMENT REQUESTED] /*/, it shall pay Acusphere [CONFIDENTIAL
            TREATMENT REQUESTED] /*/% of Acusphere's costs of providing such
            materials. Any additional supply of Product required for such
            clinical trials shall be supplied by Acusphere at the then-current
            Acusphere Manufacturing Cost.

                   (ii)    If Nycomed desires to conduct additional clinical
            trials to support marketing of the Product in the Territory for the
            Primary Indication, and such studies are not required by Competent
            Authorities to market the Product in the Territory or to establish
            reimbursement price(s) for the Product in the Territory, then the
            parties shall discuss the design of such clinical trials and tests.
            Nycomed will take due consideration to the potential interference
            such trial may have on Acusphere's FDA approval before starting any
            such trial. For the avoidance of any doubt, Nycomed shall make the
            final determination as to the design of such clinical trials and
            tests and shall execute such clinical trials and tests at Nycomed's
            sole cost and expense; provided that Nycomed will consider the
            effect of such designs on the marketing and sale of the Product
            outside the Territory. Acusphere shall provide Nycomed with
            reasonable telephone and administrative support in such clinical
            trials and tests and shall supply to Nycomed reasonable amounts of
            the Product necessary for such additional clinical trials and tests
            ([CONFIDENTIAL TREATMENT REQUESTED] /*/ vials) free of charge;
            provided that if Nycomed requires any such clinical trial materials
            prior to [CONFIDENTIAL TREATMENT REQUESTED] /*/, it shall pay
            Acusphere [CONFIDENTIAL TREATMENT REQUESTED] /*/% of Acusphere's
            costs of providing such materials.. Any additional supply of Product
            required for such clinical trials shall be supplied by Acusphere at
            the then-current Acusphere Manufacturing Cost.

                   (iii)   Acusphere shall consider providing Nycomed, at no
            cost, with up to an aggregate of [CONFIDENTIAL TREATMENT REQUESTED]
            /*/ vials of Product to be provided by Nycomed as free samples to
            prospective customers.

          (c) REGULATORY AND CLINICAL DOCUMENTS. Nycomed will own all
     documentation, including all notes, summaries and analyses related thereto,
     developed in connection with such clinical trials and regulatory
     submissions in the Territory (the "Clinical Documentation") and the results
     of such clinical testing (the "Results"); provided that Nycomed shall
     provide Acusphere with copies of all the Clinical Documentation and the
     Results; and further provided, that Nycomed shall provide Acusphere with
     reasonable access to and full use of the Clinical Documentation and the
     Results.

          (d) AUDIT OF PRODUCT COSTS. Nycomed shall have the right to cause an
     independent, certified public accountant reasonably acceptable to Acusphere
     to audit

                                       15
<Page>

     those records of Acusphere relating to the calculation of those costs and
     expenses of Acusphere for which Nycomed is responsible under this Section
     2.02 for the sole purpose of verifying such costs and expenses. Such audits
     may be exercised during normal business hours no more than once in a twelve
     (12) month period upon at least ten (10) days prior written notice.

     Section 2.03. COMMERCIALLY REASONABLE EFFORTS TO COMMERCIALIZE.

     Nycomed shall use all commercially reasonable efforts to diligently pursue
approval of the Product in each Primary Jurisdiction for use in the Field (as
such term is defined in Section 3.02(e), below) and in each Secondary
Jurisdiction unless there is Reasonable Cause (as such term is defined in
Section 3.02 (d), below) not to launch.

     Section 2.04. COMMERCIALIZATION.

     Nycomed, at its own expense and discretion, will be responsible for
conducting all sales and marketing activities, including, but not limited to,
sales calls and presentations, medical education, trade shows and market
research related to selling or marketing the Product within the Territory and
shall pay all duties, fees, tariffs and similar obligations required to market
the Product in the Territory.

     Section 2.05. AVAILABILITY OF RESOURCES; COOPERATION.

     Each Party shall maintain laboratories, offices and/or other facilities
reasonably necessary to carry out the activities to be performed by such Party
pursuant to the European Development Program or the U.S. Development Program, as
applicable. Upon reasonable advance notice, each Party agrees to make its
employees reasonably available at their respective places of employment to
consult with the other Party on issues arising in connection with any request
from any regulatory agency, including, without limitation, regulatory,
scientific, technical and clinical testing issues. The cost of such availability
of employees shall be borne by the requesting Party.

                                   ARTICLE III

                                     LICENSE

     Section 3.01. LICENSE FEE.

     In partial consideration for the License granted under Section 3.02(a),
Nycomed shall pay to Acusphere an initial one-time non-refundable (except as set
forth in this Agreement) license fee equal to Four Million Dollars ($4,000,000)
three business days after the Effective Date by wire transfer of immediately
available funds to an account to be designated by Acusphere to Nycomed prior to
the Effective Date.

     Section 3.02. LICENSE TERMS.

                                       16
<Page>

     The terms and conditions of the exclusive license (the "License") granted
by Acusphere to Nycomed shall be as follows:

          (a) LICENSE GRANT. Subject to the terms of this Agreement, Acusphere
     hereby grants to Nycomed an exclusive license under the Acusphere
     Technology to use, develop, market, advertise, promote, distribute, offer
     for sale, sell, import, package and label, but not to make or have made,
     the Product in the Territory for use in the Field, with a right to
     sublicense in accordance with this Section 3.02, and agrees to transfer the
     Acusphere Know-How to Nycomed, to the extent Nycomed reasonably finds it
     necessary and sufficient to exercise its rights and perform its obligations
     hereunder. This exclusive license can only be transferred by Nycomed on the
     basis set forth in Section 19.02.

          (b) RIGHT TO SUBLICENSE WITHOUT MANUFACTURING. Subject to the terms of
     this Agreement and with the prior written approval of Acusphere, such
     approval not to be unreasonably withheld, Nycomed shall have the right to
     grant a sublicense of its rights under Section 3.02(a) to a Third Party;
     provided that such Third Party does not market a Competitive Product in the
     Territory. Nycomed shall continue to be responsible for performance of such
     obligations despite any sublicense.

          (c) LICENSE TO MANUFACTURE AND SUBLICENSE RIGHT TO MANUFACTURE.
     Subject to the terms of this Agreement, Nycomed shall have the right to
     grant, only with Acusphere's prior written consent, such consent not to be
     unreasonably withheld, conditioned or delayed, a sublicense under the
     Acusphere Technology to Manufacture the Product, under the non-exclusive
     license granted to Nycomed under Section 6.06 and in accordance with the
     terms set forth therein. At Acusphere's request, as part of such approval
     process, Nycomed shall provide Acusphere with a copy of such portions of
     any such sublicense as relate to confidentiality or intellectual property
     rights. Nycomed shall be responsible for and shall guarantee the
     performance by the sublicensee of such obligations. Any such sublicensee
     shall be obliged to Manufacture Product in accordance with Applicable Laws
     and in accordance with the Specifications and Manufacturing Process used by
     Acusphere. Notwithstanding anything in this Agreement to the contrary, in
     no event shall Nycomed have the right to grant any sublicense to the
     Acusphere Technology to any Manufacturing Competitor, unless no party who
     is not a Manufacturing Competitor is capable of Manufacturing the Product
     in a timely manner.

          (d) LICENSE TERMINATION. If Nycomed has not made the First Commercial
     Sale of Product in each Primary Jurisdiction within [CONFIDENTIAL TREATMENT
     REQUESTED] /*/ after Governmental Approval has been received for the
     Product in such Primary Jurisdiction, or has not made the First Commercial
     Sale of Product in each Secondary Jurisdiction within [CONFIDENTIAL
     TREATMENT REQUESTED] /*/ after Governmental Approval has been received for
     the Product in such Secondary Jurisdiction and provided that Acusphere has
     Launch Quantities of the Product available for sale within the applicable
     Jurisdiction, then the following shall occur: (1) Acusphere shall have the
     right to grant a license to a Third Party, to market, advertise, promote,
     distribute, offer for sale, sell or import the Product in such

                                       17
<Page>

     Jurisdiction or Jurisdictions; (2) Acusphere shall have the right by
     written notice to immediately terminate the licenses granted to Nycomed
     within such Jurisdiction or Jurisdictions under this Agreement and (3)
     Nycomed shall grant to Acusphere, with respect to each such Jurisdiction,
     an irrevocable, non-exclusive, royalty-free license, with the right to
     sublicense, to use the Clinical Documentation, the Results and the
     Marketing Authorizations and make any required filings with Competent
     Authorities, only to the extent necessary and sufficient for Acusphere or
     its licensee to market the Product; provided, however, such rights shall
     not include any license or other right to use Nycomed's design, trademarks
     or trade dress and provided that such rights shall not include any license
     or other right to the Marks in such Jurisdiction. Notwithstanding the
     foregoing, if Nycomed fails to make the First Commercial Sale in a
     particular Secondary Jurisdiction because of Reasonable Cause (after
     notifying Acusphere in writing as to the specifics and nature of such
     Reasonable Cause), then its obligation to make the First Commercial Sale in
     such Secondary Jurisdiction shall be deferred for so long as such
     Reasonable Cause exists, and the consequences set forth in clauses (1), (2)
     and (3) above shall be inapplicable. For purposes hereof "Reasonable Cause"
     shall be deemed to exist if Nycomed reasonably determines that launch would
     not be commercially viable in such Jurisdiction or that launch in such
     jurisdiction would substantially limit the commercial potential of the
     Product in other Jurisdictions; provided that Nycomed shall, prior to
     making such determination and from time to time if requested by Acusphere
     (but no more than once per year), provide Acusphere with evidence to
     support such determination.

          (e) FIELD DEFINITION; SECONDARY INDICATIONS. The definition of "Field"
     for purposes of this Agreement shall include both (A) the evaluation of
     coronary heart disease (the "Primary Indication") and (B) such other
     medical indications for the Product ("Secondary Indications"), as may be
     added to the Field pursuant to this Subsection 3.02 (e).

                   (i)     If at any time Nycomed desires to commence a
            development program in the Territory for a particular Secondary
            Indication, it shall so notify Acusphere in writing (such
            notification to include, without limitation, a cost-sharing
            proposal, along with an explanation of the rationale for commencing
            the development program, and information on market size, opportunity
            and the time and cost involved prior to approval of an MAA
            submission). If Acusphere reasonably determines that such
            development program would damage or interfere with the market for
            the Product outside the Territory, it will so notify Nycomed in
            writing within 90 days after receipt of the notice from Nycomed. If
            Acusphere does not provide such notice, then Nycomed shall be free
            to commence such development program, and such Secondary Indication
            shall be added to the Field. If Acusphere wishes to participate in
            such development, it shall so notify Nycomed in writing during such
            90 day period, and the Parties shall for an additional 90 days
            negotiate in good faith to agree on a cost-sharing arrangement with
            regard to such program. It is expected that such cost-sharing
            arrangement would provide for Acusphere to have the right to use
            data generated by such program to develop the Secondary Indication
            in the United States and elsewhere outside the Territory in return
            for

                                       18
<Page>

            reimbursement of [CONFIDENTIAL TREATMENT REQUESTED] /*/% of the
            costs of such program (plus [CONFIDENTIAL TREATMENT REQUESTED] /*/%)
            unless it is determined that the relative size of the market for
            such Secondary Indication in the United States as compared to inside
            the Territory is not [CONFIDENTIAL TREATMENT REQUESTED] /*/. If no
            agreement is reached within such 90 day period, Nycomed shall have
            the right to develop the Product for the Secondary Indication within
            the Territory, the Secondary Indication shall be added to the Field,
            and Acusphere shall have no right to use the data generated by
            Nycomed in such development for commercialization of the Secondary
            Indication outside of the Territory, but shall have access to such
            data for regulatory and pharmacovigilance purposes. Any inventions
            created by Nycomed in the conduct of such development (provided that
            they are not Improvements, as such term is defined in this
            Agreement) shall be owned solely by Nycomed.

                   (ii)    At any time after receipt of the first Governmental
            Approval for the Product in the Territory for the Primary
            Indication, but prior to the time that Nycomed has begun a
            development program in the Territory with respect to a particular
            Secondary Indication (as evidenced by the commencement of Proof of
            Concept Trials of the Product for use in such Secondary Indication,
            after completion of the procedures set forth in paragraph (i) of
            this Subsection 3.02 (e)), Acusphere shall be entitled to develop
            the Product for such Secondary Indication in the Territory by itself
            or through arrangements with a Third Party; provided that at such
            time as Acusphere (or a Third Party acting on its behalf) shall have
            completed a Proof of Concept Trial with respect to such Secondary
            Indication Acusphere shall notify Nycomed in writing of its intent
            to go forward with such development, and shall give Nycomed all
            information related thereto as may be reasonably required for
            Nycomed to determine whether or not it wishes to proceed to develop
            such Secondary Indication (such information to include, without
            limitation, the data from such Proof of Concept Trial, a
            cost-sharing proposal, along with an explanation of the rationale
            for commencing the development program, and information on market
            size, opportunity and the time and cost involved prior to approval
            of an MAA submission). If Nycomed so requests in writing within such
            ninety (90) day period, the Parties shall, for 90 days thereafter,
            engage in good faith negotiations regarding an arrangement for
            Nycomed to obtain an exclusive license to such Secondary Indication
            within the Territory. Such exclusive license to the Secondary
            Indication within the Territory shall be given on the same terms and
            conditions as for the Primary Indication set out in this Agreement,
            with exception of payment for U.S. Development Program as provided
            for in Section 2.02 (a) and with exception of payment of a license
            fee as set forth in Section 3.01 or Milestone Payments as provided
            for in Section 4.03 to Acusphere; provided that such agreement shall
            provide for Nycomed to reimburse Acusphere for [CONFIDENTIAL
            TREATMENT REQUESTED] /*/ of the costs of such program (plus
            [CONFIDENTIAL TREATMENT REQUESTED] /*/) unless it is determined that
            the relative size of the market for such Secondary Indication in the
            United States as compared to inside the

                                       19
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            Territory is not [CONFIDENTIAL TREATMENT REQUESTED] /*/. If an
            agreement is reached, then such Secondary Indication shall be added
            to the definition of Field for all purposes of this Agreement. If no
            agreement is reached within such 90 day period, then Acusphere shall
            thereafter be free to develop such Secondary Indication in the
            Territory by itself or through a Third Party (provided that no
            agreement with a Third Party shall provide such Third Party with
            terms substantially more favorable to such Third Party than those
            last offered to Nycomed), Nycomed shall cease to have the right to
            commence a development program with respect to such Secondary
            Indication and such Secondary Indication shall no longer be
            available for inclusion in the definition of Field. In such event,
            Acusphere agrees to market the Product for such Secondary Indication
            under a brand name that is different from the Marks or any other
            trademark used by Nycomed to market the Product for the Field and to
            take all actions as may be commercially reasonable and consistent
            with Applicable Law not to violate or jeopardize the market for the
            Product in the Territory for the Field.

     Section 3.03. MARKS.

     Subject to the terms and conditions of this Agreement, Acusphere hereby
grants to Nycomed an exclusive, royalty-free right to use the Marks in the
Territory in connection with the use, development, marketing, advertising,
promotion, distribution and sale of the Product in the Field. Acusphere shall
have the right to monitor Nycomed's use of the Marks for the purpose of
protecting and maintaining the standards of quality maintained by Acusphere for
products sold under the Marks and for use of the Marks. This license shall
terminate upon termination of this Agreement.

     Section 3.04. OWNERSHIP OF IMPROVEMENTS.

     All right, title and interest in and to any Improvements made or conceived
during and as a direct result of either Party's work in connection with this
Agreement, shall be owned by Acusphere.

                                   ARTICLE IV

                         ROYALTY AND MILESTONE PAYMENTS

     Section 4.01.  ROYALTY PAYMENTS.

     Nycomed shall pay to Acusphere a royalty based on annual Net Sales as set
forth below, for a period equal to the Royalty Term for the Product in each
Jurisdiction as follows:

          (a) [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL
     TREATMENT REQUESTED] /*/%) of the first [CONFIDENTIAL TREATMENT REQUESTED]
     /*/ ($[CONFIDENTIAL TREATMENT REQUESTED] /*/) of Net Sales of Product;

          (b) [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent

                                       20
<Page>

     ([CONFIDENTIAL TREATMENT REQUESTED] /*/%) of the Net Sales of Product in
     excess of [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL TREATMENT
     REQUESTED] /*/) but less than [CONFIDENTIAL TREATMENT REQUESTED] /*/
     ($[CONFIDENTIAL TREATMENT REQUESTED] /*/);

          (c) [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL
     TREATMENT REQUESTED] /*/%) of the Net Sales of Product in excess of
     [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL TREATMENT REQUESTED]
     /*/) but less than [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL
     TREATMENT REQUESTED] /*/); and

          (d) [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL
     TREATMENT REQUESTED] /*/%) of the Net Sales of Product in excess of
     [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL TREATMENT REQUESTED]
     /*/).

     All Royalty payments due to Acusphere under this Agreement shall be paid
within forty five (45) days of the end of each calendar quarter, unless
otherwise specifically provided herein. They shall be calculated based on Net
Sales in each Jurisdiction's currency in which Net Sales have occurred, and
shall be converted to U.S. Dollars as of the end of the applicable calendar
quarter.

     Section 4.02. TECHNOLOGY ACCESS AND TRADEMARK USAGE FEE.

     Upon termination of the Royalty Term, on a Jurisdiction-by-Jurisdiction
basis, and until the end of the Term, Nycomed shall pay to Acusphere the
Technology Access and Trademark Usage Fee in lieu of the royalty payments that
would otherwise be due to Acusphere hereunder.

     All Technology Access and Trademark Usage Fee payments due to Acusphere
under this Agreement shall be paid within forty five (45) days of the end of
each calendar quarter, unless otherwise specifically provided herein.

     Section 4.03. MILESTONE PAYMENTS.

     Nycomed shall pay to Acusphere, as licensing fees, the following milestone
payments within forty-five (45) days after the occurrence of the specified
milestone event:

          (a) [CONFIDENTIAL TREATMENT REQUESTED] /*/ upon receipt of the first
     Acceptance for Filing of an MAA for the Product in any Primary
     Jurisdiction, provided that Acusphere has used all commercially reasonable
     efforts to fulfill any and all of its obligations under the Intellectual
     Property Strategy to be performed before such time;

          (b) [CONFIDENTIAL TREATMENT REQUESTED] /*/ upon the First Commercial
     Sale of the Product in any Jurisdiction, provided that Acusphere has used
     all commercially reasonable efforts to fulfill any and all of its
     obligations under the Intellectual Property Strategy to be performed before
     such time.

                                       21
<Page>

For the avoidance of doubt, the milestone payments referred to in this Section
4.03 shall be paid only once by Nycomed.

     Section 4.04. SALES MILESTONE PAYMENTS.

     Nycomed shall pay to Acusphere the following milestone payments within
forty-five (45) days after the end of the calendar quarter in which the
specified sales milestone event occurs:

          (a) [CONFIDENTIAL TREATMENT REQUESTED] /*/ when the aggregated Net
     Sales of Product in the Territory for the calendar year first exceed
     [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL TREATMENT REQUESTED]
     /*/);

          (b) [CONFIDENTIAL TREATMENT REQUESTED] /*/ when the aggregated Net
     Sales of Product in the Territory for the calendar year first exceed
     [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL TREATMENT REQUESTED]
     /*/);

          (c) [CONFIDENTIAL TREATMENT REQUESTED] /*/ when the aggregated Net
     Sales of Product in the Territory for the calendar year first exceed
     [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL TREATMENT REQUESTED]
     /*/);

          (d) [CONFIDENTIAL TREATMENT REQUESTED] /*/ when the aggregated Net
     Sales of Product in the Territory for the calendar year first exceed
     [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL TREATMENT REQUESTED]
     /*/);

          (e) [CONFIDENTIAL TREATMENT REQUESTED] /*/ when the aggregated Net
     Sales of Product in the Territory for the calendar year first exceed
     [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL TREATMENT REQUESTED]
     /*/).

     For the avoidance of doubt, each of the milestone payments referred to in
this Section 4.04 shall be paid only once by Nycomed.

     Section 4.05. REPORTS.

          (a) REPORTS. Nycomed shall furnish to Acusphere a quarterly written
     report showing in reasonably specific detail, on a Jurisdiction by
     Jurisdiction basis, (a) the calculation of Net Sales; (b) royalties payable
     in United States' Dollars, if any, which shall have accrued hereunder based
     upon Net Sales; (c) withholding taxes, if any, required by law to be
     deducted with respect to such sales; (d) the dates of the First Commercial
     Sales of the Product in any Jurisdiction during the reporting period; and
     (e) the exchange rates used to determine the amount of United States'
     Dollars (collectively, the "Royalty Statement"). Royalty Statements shall
     be due as soon as possible, but in any event no later than forty-five (45)
     days following the close of each calendar quarter. Upon replacement of the
     Royalty by the Technology Access and Trademark Usage Fee,

                                       22
<Page>

     on a Jurisdiction-by-Jurisdiction basis, Nycomed shall provide similar
     quarterly written reports to Acusphere (collectively, the "Technology
     Access and Trademark Usage Fee Statement"). Technology Access and Trademark
     Usage Fee Statements shall be due as soon as possible, but in any event no
     later than forty-five (45) days following the close of each calendar
     quarter. In addition, Nycomed shall furnish Acusphere, for its information
     only, with reports of gross sales of the Product in the Primary
     Jurisdictions for each of the two first months of each calendar quarter,
     within ten days after the end of such month.

          (b) EXCHANGE RATE; MANNER AND PLACE OF PAYMENT. All payments hereunder
     shall be payable in United States dollars. With respect to each quarter,
     whenever conversion of payments from any foreign currency shall be
     required, such conversion shall be made at the rate of exchange published
     by the European Central Bank (www.ecb.int) on the last business day of the
     applicable calendar quarter. All payments owed under this Agreement shall
     be made by wire transfer to a bank account designated by Acusphere, unless
     otherwise specified in writing by Acusphere.

          (c) LATE PAYMENTS. In the event that any payment, including contingent
     payments, due hereunder is not made when due, each such payment shall
     accrue interest from the date due at Prime Rate of Interest plus three
     percent per annum; provided that no interest shall be payable during any
     period in which a payment is disputed. The payment of such interest shall
     not limit Acusphere from exercising any other rights it may have under this
     Agreement as a consequence of the lateness of any payment.

          (d) RECORDS AND AUDITS. During the Term and for a period of five (5)
     years thereafter or as otherwise required in order for Acusphere to comply
     with Applicable Law, Nycomed shall keep complete and accurate records in
     sufficient detail to permit Acusphere to confirm the completeness and
     accuracy of: (i) the information presented in each Royalty Statement and/or
     Technology Access and Trademark Usage Fee Statement and all payments due
     hereunder and; (ii) the calculation of Net Sales. Nycomed shall permit an
     independent, certified public accountant reasonably acceptable to Nycomed
     to audit and/or inspect those records of Nycomed (including but not limited
     to financial records) that relate to Net Sales, Royalty Statements,
     Technology Access and Trademark Usage Fee Statements for the sole purpose
     of: (A) verifying the completeness and accuracy of the Royalty Statements
     and/or the Technology Access and Trademark Usage Fee Statements; (B)
     verifying the calculation of Net Sales and (C) to confirm Royalty payments,
     Technology Access and Trademark Usage Fee payments for the Product for the
     previous year. Such inspection shall be conducted during Nycomed's normal
     business hours, no more than once in any twelve (12) month period and upon
     at least thirty (30) days prior written notice by Acusphere to Nycomed. If
     such accounting firm concludes that such payments were underpaid for the
     preceding year, Nycomed shall pay Acusphere the amount of any such
     underpayments for the preceding year, plus interest at a rate equal to the
     Prime Rate of Interest, within thirty (30) days of the date Acusphere
     delivers to Nycomed such accounting firm's report so concluding that such
     payments were underpaid for the preceding year. If such accounting firm
     concludes that such payments were overpaid for the preceding year,
     Acusphere shall provide Nycomed with a credit in the amount of any such
     overpayments for the preceding year, within

                                       23
<Page>

     thirty (30) days of the date Acusphere delivers to Nycomed such accounting
     firm's report so concluding that such payments were overpaid for the
     preceding year. Acusphere shall bear the full cost of such audit unless
     such audit discloses an underpayment by more than five percent (5%) of the
     amount due for the preceding year. In such case, Nycomed shall bear the
     full cost of such audit.

          (e) TAXES. All taxes levied on account of the payments accruing to
     Acusphere under this Agreement shall be paid by Acusphere for its own
     account, including taxes levied thereon as income to Acusphere. If
     provision is made in law or regulation requiring withholding, such tax
     shall be deducted from the payment made by Nycomed, paid to the proper
     taxing authority and a receipt of payment of the tax secured and promptly
     delivered to Acusphere. Each Party agrees to assist the other Party in
     claiming exemption from such deductions or withholdings under any double
     taxation or similar agreement or treaty from time to time in force.

          (f) PROHIBITED PAYMENTS. Notwithstanding any other provision of this
     Agreement, if Nycomed is prevented from paying any payments by virtue of
     the statutes, laws, codes or governmental regulations of the Jurisdiction
     from which the payment is to be made, then such payment may be paid by
     depositing funds in the currency in which it accrued to Acusphere's account
     in a bank acceptable to Acusphere in the Jurisdiction whose currency is
     involved.

                                    ARTICLE V

                                COMMERCIALIZATION

     Section 5.01. PROMOTION AND MARKETING OBLIGATIONS.

          (a) MARKETING EFFORTS. Nycomed agrees to use all commercially
     reasonable efforts to promote the sale, marketing and distribution of the
     Product in each Jurisdiction (except for Secondary Jurisdictions where
     there is Reasonable Cause (as such term is defined in Section 3.02 (d) not
     to launch), consistent with accepted business practices devoting the same
     level of efforts as it devotes to its own products of comparable market
     potential. "Comparable market potential" shall be fairly determined by
     Nycomed in good faith and shall be based upon market size, price,
     competition and general marketing parameters. Each Party shall promptly
     advise the other Party of any issues that materially and adversely affect
     its ability to market the Product in the Territory. In such event, senior
     executives of Nycomed and Acusphere shall meet and in good faith discuss
     what actions should be taken in light of such issues. It is clearly
     understood that Nycomed, alone, shall determine the sales prices for the
     Product in the Territory.

          (b) PACKAGING. Acusphere shall package the Product in compliance with
     the Bulk Packaging Specifications and Applicable Laws. Acusphere, in
     consultation with Nycomed, shall be responsible for assuring that such
     packaging conforms with all Applicable Laws, if any, of the FDA for export
     of the Product into the Territory and that the vials comply with the Bulk
     Packaging Specifications. Unless the Parties otherwise agree in writing,
     Nycomed, in consultation with Acusphere, shall be responsible for

                                       24
<Page>

     packaging the Product for resale in the Territory in accordance with the
     Final Packaging Specifications and assuring that final packaging and
     labeling comply with all Applicable Laws where such Product is to be
     distributed for sale in the Territory. All additional incremental costs
     resulting from changes to the Packaging Specifications made at the request
     of Nycomed that are not required to export or import the U.S. Product to
     countries in the Territory under Applicable Laws shall be borne by Nycomed.

          (c) DESIGN. Nycomed shall be free to determine, in consultation with
     Acusphere, all use within the Territory of the Marks, logo and design
     related to the Products to be used on packaging material as well as
     promotion material, and shall ensure compliance with Applicable Laws in the
     Territory related hereto. Nycomed hereby grants Acusphere the right to use
     any such logo, design, trade dress (other than Nycomed's trademarks)
     outside the Territory.

          (d) SALES FORECASTS, MARKETING PLANS AND REPORTS. Sixty (60) days
     prior to the expected date of First Commercial Sale in the Territory and at
     the beginning of each calendar year thereafter, Nycomed shall submit to the
     Steering Committee in writing the annual marketing, sales and distribution
     plan for the Product, including its sales forecasts, detailing Nycomed's
     and its Affiliates' proposed marketing, sales and distribution strategy and
     tactics for the sale and distribution of Product during such calendar year,
     or portion thereof. In addition, upon the request of Acusphere, Nycomed
     shall submit to the Steering Committee copies of any market research
     reports relating to Product sales and Product competition which Nycomed or
     its Affiliates commission or otherwise obtain to the extent permissible by
     the agency preparing the report. To the extent the foregoing information is
     contained in plans or reports which contain information about other
     products or markets, Nycomed may submit to the Steering Committee only
     those excerpts from such plans or reports which relate to the Product and
     Product competition. In addition, at the request of Nycomed, Acusphere
     shall submit to the Steering Committee any market research reports for the
     Product it creates or acquires for its own use; provided that the terms of
     acquisition of such report permit Acusphere sharing it with the Steering
     Committee. For the avoidance of doubt, nothing in this Agreement shall
     obligate Acusphere to create or acquire any such reports.

          (e) STEERING COMMITTEE.

                   (i)     FORMATION AND FUNCTION. Promptly after the Effective
            Date, Nycomed and Acusphere will each appoint two (2) senior
            representatives to a committee (the "Steering Committee") that shall
            have oversight for any activity under this Agreement for the
            Territory. Acusphere will appoint one of their representatives as
            chairman of the Steering Committee for the initial twelve (12)
            months. Thereafter, the chairmanship will rotate between a Nycomed
            member and an Acusphere member every twelve (12) months. The
            Steering Committee shall act only with the unanimous consent of its
            members. Except as set forth in Section 12.01, the Steering
            Committee will be consulted by both Parties on all major decisions
            in the development, manufacture, intellectual property protection
            and marketing of the Product in each Jurisdiction in the

                                       25
<Page>

            Territory, including, without limitation, in the following areas as
            they relate to the Product:

                         (A) Product positioning in the marketplace;

                         (B) quantity of direct selling efforts, including the
                 number of sales details to be made;

                         (C) extent and degree of non-personal selling and
                 promotional efforts;

                         (D) quantity and content of workshops and medical
                 symposia;

                         (E) design and implementation of a Phase IV clinical
                 study program to support the Product;

                         (F) selection of physicians for a medical steering
                 committee and speakers bureau;

                         (G) planning for regulatory submissions in the
                 Territory;

                         (H) dispute resolution regarding sales, marketing and
                 promotional activities related to the Product;

                         (I) intellectual property matters, including adoption
                 of the Intellectual Property Strategy and matters pertaining to
                 the Marks;

                         (J) manufacturing issues; and

                         (K) design and performance of other clinical studies in
                 any Jurisdiction of the Territory.

            Nycomed, alone, will be responsible for making the final decisions
            on the sales and marketing of the Product within the Territory
            regardless of the action or inaction of the Steering Committee.
            Notwithstanding the foregoing, for the avoidance of doubt,
            Acusphere, alone, shall make the final decision on all matters
            concerning the Manufacture of the Product, unless and until Nycomed
            exercises its Manufacturing rights, as provided in Section 6.06.

                   (ii)    MEETINGS. The Steering Committee will meet every
            three (3) months and at such other times as a Party may request,
            alternating between Roskilde, Denmark and Boston, MA, USA and will
            otherwise communicate regularly by telephone, email, facsimile
            and/or video conference. The chairman of the Steering Committee
            shall prepare minutes of all meetings. Each Party recognizes the
            importance of the Steering Committee in the success of the
            Collaboration and will use diligent efforts to cause all of its
            representatives on the Steering Committee to attend all meetings of
            the Steering Committee. A Party may change any of its appointments
            to the

                                       26
<Page>

            Steering Committee at any time upon giving written notice to the
            other Party. Each Party shall bear its own costs related to any such
            meetings.

                   (iii)   WORKING GROUPS. The Steering Committee may establish
            appropriate working groups for the marketing and any other
            activities necessary for the development and marketing of the
            Product in the Territory. Each working group shall meet at such
            intervals as may be specified by the Steering Committee, and at such
            other times as a Party may request, alternating between Roskilde,
            Denmark and Boston, MA, USA and will otherwise communicate regularly
            by telephone, email, facsimile and/or video conference. All actions
            of a working group shall be by unanimous consent of its members and
            be reported to the Steering Committee in writing for approval by the
            Steering Committee. Any disputes or disagreements within a working
            group shall be resolved by the Steering Committee.

                                   ARTICLE VI

                             MANUFACTURE AND SUPPLY

     Section 6.01. AGREEMENT TO SUPPLY PRODUCT.

     Subject to the terms hereof, Nycomed agrees to purchase exclusively from
Acusphere, and Acusphere agrees to Manufacture for, and sell to Nycomed for a
period of five years following First Commercial Sale in the Territory, Nycomed's
total requirements for the Product in the Territory on the terms and conditions
set forth herein; provided that the Parties agree to consider renewing such
exclusive purchasing relationship at the end of the five year period and any
subsequent renewal period and that, if Nycomed so requests, Acusphere shall use
commercially reasonable efforts to continue to supply Nycomed its total
requirements of Product on the terms set forth in this Agreement. Acusphere may
subcontract any part of the Manufacturing Process for the Product to a Third
Party provided: (a) the Product and the facilities continue to meet the
requirements as defined in this Agreement, (b) Acusphere or Nycomed has obtained
all required Governmental Approvals to subcontract any part of the Manufacturing
Process for the Product to be sold in the Territory (c) Acusphere will solely
bear any and all additional costs to the Manufacturing Costs resulting directly
and indirectly from such subcontracting and shall continue to be responsible for
performance of its obligations under this Agreement despite any such
sublicensing and (d) the Third Party or Nycomed has obtained all required
Governmental Approvals for the Manufacturing Process for the Product to be sold
in the Territory. The costs for release testing of Product on first importation
into the Territory shall be borne exclusively by Nycomed. During the Term of
this Agreement, Acusphere shall not sell Product directly in the Territory or to
any Third Party for active resale within the Territory, except for such
countries within the Territory where Acusphere has co-marketing rights pursuant
to Section 12.01 or in which Nycomed's license has terminated pursuant to
Section 3.02(d).

     Section 6.02. QUALITY ASSURANCE; CHANGES.

          (a) Acusphere shall Manufacture the Product in accordance with the
     Specifications and Applicable Laws. Any changes in the Specifications,
     other than those

                                       27
<Page>

     required by Applicable Laws or a Competent Authority, shall be agreed in
     writing between the Parties. Acusphere shall update the Specifications
     after agreed changes, and shall provide Nycomed with such new
     Specifications after revision. If Acusphere wishes to make any changes in
     the Manufacturing Process or in Acusphere's quality assurance procedures
     regarding the Product to be sold in the Territory Acusphere shall consult
     in writing with Nycomed. Acusphere shall give Nycomed in writing all
     relevant information regarding the proposed changes, in order for Nycomed
     to assess, among other things, whether a notification to the relevant
     Competent Authorities is needed, and the Parties shall following such
     assessment agree to a date for implementation of such changes. Proposed
     changes which require changes to the Specifications or which might render
     Acusphere unable to supply Product in accordance with the terms of this
     Agreement may not be implemented without the applicable Governmental
     Approval of any Competent Authority and Nycomed's prior, written consent
     thereto, which consent will not be unreasonably withheld, conditioned or
     delayed by Nycomed.

          (b) Except for changes required by a Competent Authority, Acusphere
     shall bear any and all costs of implementing any changes it initiates, and
     Nycomed shall bear any and all costs of implementing any changes it
     initiates.

          (c) Each Party shall promptly notify the other Party in writing of any
     changes required by a Competent Authority in the Territory in the
     Specifications or Acusphere's quality assurance procedures or Manufacture.
     Acusphere shall use all commercially reasonable efforts to implement any
     such changes if feasible; provided that Nycomed shall be responsible for
     obtaining all necessary approvals from the Competent Authorities in the
     Territory. The costs of implementing changes required by Competent
     Authorities that only affect the Product sold in the Territory shall be
     borne solely by Nycomed. The costs of implementing changes required by
     Competent Authorities that only affect the Product sold outside the
     Territory shall be borne solely by Acusphere. The costs of implementing
     changes required by Competent Authorities (whether within or without the
     Territory) that affect not only the Product sold inside the Territory but
     also AI-700 sold by Acusphere or its partners outside the Territory, shall
     be borne [CONFIDENTIAL TREATMENT REQUESTED] /*/% by Acusphere and
     [CONFIDENTIAL TREATMENT REQUESTED] /*/% by Nycomed, unless it is determined
     that the relative size of the market for the Product in the US and all
     other countries outside the Territory where the AI-700 is being actively
     sold as compared to the Territory is not [CONFIDENTIAL TREATMENT REQUESTED]
     /*/.

     Section 6.03. ACUSPHERE'S DUTIES.

                                       28
<Page>

     Acusphere covenants to Manufacture the Product in accordance with the
Specifications and Applicable Laws, and to furnish to Nycomed with every
Shipment a written certificate of analysis and Certificate of Compliance that
confirms conformity of the Product to the Specifications and with Applicable
Laws regarding the importation of the Product. The Product will be subjected to
testing and release for the European markets by Nycomed at its designated
facility, at its own cost and using validated methods provided by Acusphere, in
order to verify conformance of the Product with the Specifications, Applicable
Laws and the warranties set out in Section 8.01. In addition, Acusphere shall:

          (a) as soon as possible provide Nycomed with a copy of the written
     sampling and testing procedures used by Acusphere to confirm conformity of
     the Product to the Specifications and Applicable Laws;

          (b) retain a sample of each batch of Product for a period equal to the
     lesser of (i) five (5) years or (ii) such period as required by Applicable
     Laws or the Competent Authorities. Upon the written request of Nycomed,
     Acusphere shall make such samples available to Nycomed for inspection. The
     retained sample shall be sufficient in size to allow Nycomed and Acusphere
     to perform tests to determine whether or not the Product conforms to the
     Specifications and Applicable Laws. The retained sample shall be kept under
     the same conditions as under the approved storage conditions;

          (c) maintain records to ensure Acusphere's ability to perform a
     complete lot history via lot tracing of the Product;

          (d) keep on file all manufacturing records and analytical results
     pertaining to the Manufacture of each batch of Product for a period equal
     to the longer of (i) five (5) years or (ii) such period as required by
     Applicable Laws or the Competent Authorities, with such period commencing
     on the expiration date of the last lot of the last batch of Product
     Manufactured and shipped to Nycomed. Acusphere shall make all such records
     available to Nycomed upon request;

          (e) consult on an ongoing basis with the Steering Committee on all
     aspects of the manufacturing and development of the Product, including the
     use of any subcontractors to perform part of the Manufacturing Process and
     assist Nycomed on an ongoing basis to obtain all necessary Governmental
     Approvals, in accordance with Section 2.02;

          (f) provide to Nycomed promptly after receipt by Acusphere, complete
     copies of any and all inspection reports pertaining to the Manufacture and
     development of the Product which Acusphere receives from any Competent
     Authority or the FDA.;

          (g) provide Nycomed with complete access to all existing and hereafter
     produced: (i) batch records of the Product; (ii) quality inspection reports
     of the Product, whether internally or externally generated; (iii) any and
     all investigation reports of the Product, whether internally or externally
     generated; and (iv) packaging records pertaining to the Product;

          (h) provide Nycomed with notice within forty-eight (48) hours of
     notification of any scheduled inspection by any Competent Authority of
     Acusphere's facilities, books or

                                       29
<Page>

     records, or of the facilities, books or records of any subcontractor being
     utilized by Acusphere to perform any portion or all of the Manufacture or
     development of the Product. Acusphere shall inform such Competent Authority
     that Nycomed may desire to be present at such inspection; provided that
     Nycomed's right to be present is subject to approval by such Competent
     Authority and subject to Nycomed being available at the time and date
     established by such Competent Authority. Acusphere shall use reasonable
     efforts to secure a time and date for such inspection that is reasonably
     acceptable to Nycomed; provided, however, that Acusphere alone shall have
     the right to make the final decision on all such matters; and

          (i) provide Nycomed with complete copies of the annual product reviews
     for the Product prepared for the FDA.

     Section 6.04. COMPLIANCE WITH APPLICABLE LAWS.

     Nycomed and Acusphere (if Acusphere has exercised its co-marketing rights
pursuant to Section 12.01, but only in connection with Acusphere's activities
there under) shall be responsible for compliance with Applicable Laws relating
to the import, export, promotion, marketing, sale and distribution of the
Product, including any requirements regarding initial testing and release of the
Product on first importation into the Territory and including any costs hereof.
Acusphere shall be responsible for compliance with Applicable Laws relating to
the Manufacture, product design and production of the Product, and with cGMP
relating to the Manufacture and testing of the Product for sale in the Territory
and including any costs hereof, but excluding the costs of initial testing on
import into the Territory, which shall be Nycomed's responsibility.

     Section 6.05. SUPPLY ALLOCATION.

          (a) Prior to the occurrence of a Capacity Increase Notice (as defined
     below), Acusphere agrees to supply Nycomed with all its Binding Purchase
     Orders for Product, up to the amount set forth in the Updated Unit
     Forecast. If Nycomed has submitted Binding Purchase Orders in excess of the
     amount set forth in the Updated Unit Forecast, Acusphere shall use all
     commercially reasonable efforts to fill those orders.

          (b) After the occurrence of a Capacity Increase Notice:

                   (i)     If (A) Acusphere has increased its overall production
            capacity for the Product to a level at or above [CONFIDENTIAL
            TREATMENT REQUESTED] /*/ of Projected Capacity (as defined below),
            (B) Nycomed has submitted Binding Purchase Orders in excess of the
            amount set forth in the Updated Unit Forecast and Acusphere has
            requirements in excess of the Acusphere Unit Forecast, and (C)
            Acusphere is unable to both fulfill such excess Binding Purchase
            Orders and meet such excess requirements for Product of Acusphere
            and all other customers of Acusphere, then any available capacity in
            excess of the sum of the Updated Unit Forecast and the Acusphere
            Unit Forecast shall be allocated between Nycomed, on the one hand,
            and Acusphere (including all other customers of Acusphere), on the
            other hand,

                                       30
<Page>

            [CONFIDENTIAL TREATMENT REQUESTED] /*/; and

                   (ii)    If (A) Acusphere has increased its overall production
            capacity for the Product to a level at or above [CONFIDENTIAL
            TREATMENT REQUESTED] /*/% of Projected Capacity, (B) Nycomed has
            submitted Binding Purchase Orders for no more than the amount set
            forth in the Updated Unit Forecast, and (C) Acusphere is unable to
            meet the requirements for Product of both Nycomed and Acusphere due
            to manufacturing issues that have not been resolved using all
            commercially reasonable efforts; then any available capacity will be
            allocated [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent
            ([CONFIDENTIAL TREATMENT REQUESTED] /*/%) to Nycomed and
            [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL
            TREATMENT REQUESTED] /*/%) to Acusphere (including all other
            customers of Acusphere).

          (c) For purposes hereof a "Capacity Increase Notice" shall be deemed
     to occur when Acusphere has notified Nycomed in writing (on or before
     [CONFIDENTIAL TREATMENT REQUESTED] /*/) that it commits to increase
     Projected Capacity for each of the [CONFIDENTIAL TREATMENT REQUESTED] /*/
     years after Governmental Approval by at least [CONFIDENTIAL TREATMENT
     REQUESTED] /*/%. Projected Capacity shall mean the production capacity
     shown in the capacity projection provided in writing by Acusphere to
     Nycomed prior to the date hereof.

          (d) Acusphere agrees to use all commercially reasonable efforts to
     identify or create and qualify an alternative or backup manufacturing
     facility for the Product to be operational within [CONFIDENTIAL TREATMENT
     REQUESTED] /*/ after First Commercial Sale of the Product in the Territory.

          (e) Acusphere and Nycomed shall on a regular basis inform each other
     on issues of relevance for the long term planning of the manufacture of the
     Product.

          (f) If a Capacity Increase Notice has occurred, then at Acusphere's
     request Nycomed agrees to assist Acusphere with financing the costs of
     providing increased capacity by providing up to $[CONFIDENTIAL TREATMENT
     REQUESTED] /*/ of financing. for the initial proposed increase over
     Projected Capacity. Such financing will be in a form acceptable to
     Acusphere and Nycomed and may be in the form of a loan, secured by a
     security interest in equipment to be purchased, to be repaid as a credit
     against each purchase of Product in an amount equal to that portion of the
     Actual Manufacturing Cost of such Product represented by the depreciation
     attributable to the proportional amount of Nycomed's investment in any such
     equipment purchased to expand such capacity.

     Section 6.06. FAILURE TO SUPPLY; MANUFACTURING LICENSE.

          (a) If, during any period in which the exclusive purchasing commitment
     set forth in Section 6.01 is in effect, a "Failure of Supply" as described
     in this Section 6.06 occurs (other than a Failure of Supply described in
     Section 7.06(b) below), then Nycomed shall

                                       31
<Page>

     be entitled to obtain, by written notice to Acusphere within [CONFIDENTIAL
     TREATMENT REQUESTED] /*/ after the first Failure of Supply and without any
     further action by either Party, a non-exclusive royalty-free license under
     the Acusphere Technology only to the extent necessary and sufficient to
     Manufacture the Product for sale or distribution in the Territory. Such
     license shall be sub-licensable only to the extent set forth in Section
     3.02(c). After such notice, Acusphere, upon Nycomed's written request,
     shall provide Nycomed or any Third Party manufacturer chosen by Nycomed
     within two (2) weeks of the date of such request with all Acusphere
     Know-How related to the Manufacturing Process, but only to the extent
     necessary and sufficient to exercise its rights hereunder. Acusphere shall
     also provide Nycomed with any additional documentation and materials, at
     Nycomed's expense, reasonably necessary to Manufacture the Product in the
     Territory in accordance with the license granted hereunder. Any Third Party
     manufacturer shall execute confidentiality agreements with Acusphere in
     form and substance reasonably satisfactory to Acusphere. If necessary,
     Acusphere will support the implementation of its Know-How for the
     Manufacture of the Product by providing appropriate employees giving the
     required advice at the premises of Nycomed or such Third Party.

          (b) If Nycomed exercises its right to manufacture the Product pursuant
     to paragraph (a) above, Acusphere shall, if requested by Nycomed, continue
     to supply Nycomed with Product as provided under this Agreement
     ([CONFIDENTIAL TREATMENT REQUESTED] /*/) until the earlier of[CONFIDENTIAL
     TREATMENT REQUESTED] /*/ after the initial Failure of Supply or such date
     as Nycomed has established its own manufacturing facility for the Product
     in accordance with paragraph (a) above. For avoidance of doubt, the
     allocation provisions of Section 6.05 above shall continue to apply during
     such interim period.

          (c)   For purposes of this Agreement, a "Failure of Supply" shall be
     deemed to occur if Acusphere fails to supply:

                   (i)     for the first [CONFIDENTIAL TREATMENT REQUESTED] /*/
            period after First Commercial Sale, at least [CONFIDENTIAL TREATMENT
            REQUESTED] /*/% of Nycomed's Binding Purchase Orders in the
            aggregate or [CONFIDENTIAL TREATMENT REQUESTED] /*/% of the
            aggregate requirements projected in the Updated Unit Forecast for
            such period; or

            (ii) for each [CONFIDENTIAL TREATMENT REQUESTED] /*/ period
            thereafter, at least [CONFIDENTIAL TREATMENT REQUESTED] /*/% of
            Nycomed's Binding Purchase Orders in the aggregate or [CONFIDENTIAL
            TREATMENT REQUESTED] /*/% of the aggregate requirements projected
            in the Updated Unit Forecast for such period.

          (d) Upon the first Failure of Supply (other than a Failure of Supply
     described in Section 7.06(b) below), following Nycomed's exercise of its
     right to obtain a license to Manufacture under Section 6.06(a) above, the
     Royalty payable by Nycomed hereunder shall be reduced to [CONFIDENTIAL
     TREATMENT REQUESTED] /*/% of the

                                       32
<Page>

     Royalty originally payable hereunder. Upon any second Failure of Supply
     (other than a Failure of Supply described in Section 7.06(b) below), if
     Nycomed has exercised its right to obtain a license to Manufacture under
     Section 6.06(a) above, the Royalty payable by Nycomed hereunder shall be
     reduced to [CONFIDENTIAL TREATMENT REQUESTED] /*/% of the Royalty
     originally payable hereunder. The provisions of this Section 6.06 shall
     constitute Nycomed's sole remedy in the event of a Failure of Supply,
     except in the case of gross negligence or willful misconduct by Acusphere.

          (e) If Nycomed does not exercise its right to obtain a license to
     Manufacture under Section 6.06(a) above, then upon the first Failure of
     Supply (other than a Failure of Supply described in Section 7.06(b) below),
     the Royalty payable by Nycomed hereunder shall be reduced to [CONFIDENTIAL
     TREATMENT REQUESTED] /*/% of the Royalty originally payable hereunder. Upon
     any second Failure of Supply (other than a Failure of Supply described in
     Section 7.06(b) below), the Royalty payable by Nycomed hereunder shall be
     reduced to [CONFIDENTIAL TREATMENT REQUESTED] /*/% of the Royalty
     originally payable hereunder. Any reduction in Royalty, whether to
     [CONFIDENTIAL TREATMENT REQUESTED] /*/% or [CONFIDENTIAL TREATMENT
     REQUESTED] /*/% of the Royalty originally payable hereunder, shall continue
     until Acusphere has been able to supply Nycomed with all its Binding
     Purchase Orders on a continuous basis during a [CONFIDENTIAL TREATMENT
     REQUESTED] /*/ period following the Failure of Supply, and shall
     thereafter, from the end of the last month of such [CONFIDENTIAL TREATMENT
     REQUESTED] /*/ period, be increased back to the unreduced Royalty rate;
     provided, however, that the Parties have been able to negotiate in good
     faith an amount that shall cover Nycomed's direct damages incurred during
     such Failure of Supply. Any such negotiation shall take place at the end of
     the [CONFIDENTIAL TREATMENT REQUESTED] /*/ period. Should the Parties not
     be able to negotiate in good faith an amount reflecting Nycomed's direct
     damages, such reduction in Royalty shall continue.

                                   ARTICLE VII

                                PURCHASE AND SALE

     Section 7.01. PURCHASE PRICE AND PAYMENT.

     Acusphere shall sell, and Nycomed shall purchase, Product at a price equal
to [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL TREATMENT
REQUESTED] /*/%) of the sum of (i) the Deemed Acusphere Manufacturing Cost plus
(ii) all Territory Specific Manufacturing Costs (hereinafter, the "Purchase
Price"). Acusphere shall use all commercially reasonable efforts to optimize and
decrease the Manufacturing Costs of the Products. Acusphere shall invoice
Nycomed on shipment for all Product shipped by Acusphere to Nycomed and payment
shall be due forty five (45) days from receipt of the invoice.

     Section 7.02. DETERMINATION OF DEEMED ACUSPHERE MANUFACTURING COST; AUDIT.

                                       33
<Page>

          (a) The Parties anticipate that the Acusphere Manufacturing Cost for
     the first [CONFIDENTIAL TREATMENT REQUESTED] /*/ after the First Commercial
     Sale will be between [CONFIDENTIAL TREATMENT REQUESTED] /*/ ($[CONFIDENTIAL
     TREATMENT REQUESTED] /*/) per vial and [CONFIDENTIAL TREATMENT REQUESTED]
     /*/ ($[CONFIDENTIAL TREATMENT REQUESTED]) /*/ per vial, not including any
     Territory-Specific Manufacturing Costs. No later than nine (9) months after
     filing by Nycomed of an MAA in the Territory, Acusphere shall determine
     what its anticipated Acusphere Manufacturing Costs are expected to be in
     the first year of sales, and such amount shall be the Deemed Acusphere
     Manufacturing Cost used to calculate the Purchase Price for all sales by
     Acusphere to Nycomed shipped during the first twelve months following the
     First Commercial Sale in the Territory. After the end of the first calendar
     year of sales in the Territory, and every twelve months thereafter, the
     Parties will review the actual Acusphere Manufacturing Cost for the Product
     sold to Nycomed in the preceding twelve months (the "Actual Previous Year
     Cost"). Such Actual Previous Year Cost shall be the Deemed Acusphere
     Manufacturing Cost used to calculate the Purchase Price for the ensuing
     twelve months, with effect in each year from March 1, and :

                   (i)     if the Actual Previous Year Cost was less than the
            Deemed Acusphere Manufacturing Cost used to calculate the Purchase
            Price in such year (the "Deemed Previous Year Cost"), then Acusphere
            shall provide a credit to Nycomed equal to the difference between
            the Actual Previous Year Cost and the Deemed Previous Year Cost,
            [CONFIDENTIAL TREATMENT REQUESTED] /*/; or

                   (ii)    if the Actual Previous Year Cost was greater than the
            Deemed Previous Year Cost, then Nycomed shall promptly pay to
            Acusphere the difference between the Actual Previous Year Cost and
            the Deemed Previous Year Cost, [CONFIDENTIAL TREATMENT REQUESTED]
            /*/; or

                   (iii)   if the Actual Previous Year Cost was the same as the
            Deemed Previous Year Cost, there shall be no payment or credit.

          (b) Acusphere shall furnish to Nycomed, within 45 days after the end
     of each 12 month period, a written report showing in reasonably specific
     detail the calculation of the Acusphere Manufacturing Costs for the Product
     sold in the preceding twelve months, including (a) the total actual
     manufacturing costs; split into costs per department and costs per account
     (b) allocation of costs between Nycomed and Acusphere; and (c) the
     calculation of costs per unit. In addition, for the first two years after
     First Commercial Sale Acusphere shall furnish Nycomed, for its information
     only, with quarterly written reports of Acusphere Manufacturing Costs,
     within thirty days after the end of such quarter. Thereafter, Acusphere
     shall furnish such reports only if requested by Nycomed before the end of
     the quarter for which the report is desired. It is understood that all
     reports furnished pursuant to this paragraph shall be unaudited and subject
     to adjustment in connection with Acusphere's annual audit of its financial
     statements.

                                       34
<Page>

          (c) Nycomed shall have the right, at its sole cost and expense, to
     cause an independent, certified public accountant reasonably acceptable to
     Acusphere to audit the financial records of Acusphere for the sole purpose
     of verifying the Acusphere Manufacturing Cost and the Purchase Price. Such
     audits may be exercised during normal business hours no more than once in a
     twelve (12) month period upon at least thirty (30) days prior written
     notice. Nycomed shall pay out of pocket costs of such audit unless such
     audit results in a determination of an overstatement of the Acusphere
     Manufacturing Cost by more than [CONFIDENTIAL TREATMENT REQUESTED] /*/
     percent ([CONFIDENTIAL TREATMENT REQUESTED] /*/%) of the amount claimed or
     stated as the Acusphere Manufacturing Cost, respectively, for the preceding
     year. In such case, Acusphere shall pay all of the costs of such audit. In
     addition, if such accounting firm concludes that Acusphere Manufacturing
     Costs were overstated for the preceding year, Acusphere shall provide
     Nycomed with a credit in the amount of the overpayments for the preceding
     year resulting from such overstatement, plus interest at a rate equal to
     the Prime Rate of Interest, within thirty (30) days of the date Nycomed
     delivers to Acusphere such accounting firm's report so concluding that such
     costs were overstated for the preceding year. If such accounting firm
     concludes that Acusphere Manufacturing Costs were understated for the
     preceding year, Nycomed shall pay Acusphere the amount of the underpayments
     for the preceding year resulting from, plus interest at a rate equal to the
     Prime Rate of Interest, within thirty (30) days of the date Nycomed
     delivers to Acusphere such accounting firm's report so concluding that such
     payments were underpaid for the preceding year.

     Section 7.03. PURCHASE FORMS.

     Purchase Orders, purchase order releases, confirmations, acceptances and
similar documents submitted by a Party in conducting the activities contemplated
under this Agreement are for administrative purposes only and shall not add to
or modify the terms of the Agreement. To the extent of any conflict or
inconsistency between this Agreement and any such document, the terms of this
Agreement shall govern.

     Section 7.04. CONFIRMATION.

     Acusphere shall confirm each Binding Purchase Order (to the extent provided
in Section 6.05) within five (5) business days from the date of receipt of a
purchase order for the same and shall supply the Product within a maximum of
sixty (60) business days from the date of acceptance of a Binding Purchase
Order, or later if so specified in the Binding Purchase Order during the first
twelve months after the First Commercial Sale of the Product. After such twelve
month period, Acusphere will use all commercially reasonable efforts to reduce
the lead time for the delivery of such Product to thirty (30) business days from
the date of acceptance of such Binding Purchase Order. Failure of Acusphere to
confirm any Binding Purchase Order shall not relieve Acusphere of its obligation
to supply Product ordered by Nycomed in conformity with this Agreement.

     Section 7.05. DELIVERY.

                                       35
<Page>

     Delivery terms for Product shall be FCA (Incoterms 2000) Acusphere's
manufacturing facility. Acusphere shall be responsible for shipment of the
Product at Nycomed's cost, and will choose the method of shipment unless Nycomed
specifies a specific shipment method in writing, in which case Acusphere shall
ship as directed by Nycomed. Title to any Product purchased by Nycomed shall
pass to Nycomed upon the earlier of (i) a common carrier accepting possession or
control of such Product, or (ii) passage of such Product from the loading dock
of Acusphere's facilities to Nycomed or its agent. Nycomed shall be solely
responsible for all freight and insurance expenses after title passes to
Nycomed. Nycomed shall also be responsible for any and all import or export
duties, value-added taxes, tariffs and the like relating to the sale or resale
of the Product to or in the Territory. Nycomed shall be responsible for storing
Product as specified by Acusphere and in compliance with the Governmental
Approvals and Applicable Laws.

     Section 7.06. FORECASTS AND ORDERS

          (a) Not later than six (6) months following submission of the MAA or
     other applicable regulatory filing, Nycomed shall provide Acusphere with
     the Updated Unit Forecast. The first [CONFIDENTIAL TREATMENT REQUESTED] /*/
     of such forecast shall be considered a Binding Purchase Order. Thereafter
     Nycomed shall provide Acusphere a rolling [CONFIDENTIAL TREATMENT
     REQUESTED] /*/ forecast of its purchase requirements of Product, and shall
     update same on a monthly basis. The first [CONFIDENTIAL TREATMENT
     REQUESTED] /*/ of each rolling forecast will be binding orders to purchase.
     The [CONFIDENTIAL TREATMENT REQUESTED] /*/ may be reduced from the previous
     forecast by no more than [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent
     ([CONFIDENTIAL TREATMENT REQUESTED] /*/%) per month until fixed by the
     subsequent forecast; provided that the aggregate reduction from the
     quantity set forth in the previous forecast for such [CONFIDENTIAL
     TREATMENT REQUESTED] /*/ period shall not exceed [CONFIDENTIAL TREATMENT
     REQUESTED] /*/) percent ([CONFIDENTIAL TREATMENT REQUESTED] /*/%) in
     aggregate during that [CONFIDENTIAL TREATMENT REQUESTED] /*/ period. For
     the avoidance of doubt, the rolling forecast provided for in this paragraph
     does not affect the Parties' obligations under Section 6.05 or 6.06, which
     are governed by the Updated Unit Forecast. The initial rolling forecast
     provided under this paragraph shall constitute the Updated Unit Forecast
     for purposes of Article VI of this Agreement and shall not provide for
     quantities of less than [CONFIDENTIAL TREATMENT REQUESTED] /*/% of or more
     than [CONFIDENTIAL TREATMENT REQUESTED] /*/% of the quantities shown in the
     initial Unit Forecast. To the extent that the Updated Unit Forecast does
     not provide, for any month, for quantities above the amount shown in the
     initial Unit Forecast, Nycomed shall be given supply priority over
     Acusphere (including any customers of Acusphere) for orders for such month
     up to [CONFIDENTIAL TREATMENT REQUESTED] /*/% of the amount shown on the
     initial Unit Forecast. In addition, Nycomed shall have the right to place
     orders above such unit forecasts, and Acusphere shall use all commercially
     reasonable efforts to accommodate such orders but shall not be obligated to
     give such orders priority over the orders of Acusphere or any customers of
     Acusphere, except to the extent set forth in Section 6.05.

          (b) Notwithstanding the foregoing, after the [CONFIDENTIAL

                                       36
<Page>

     TREATMENT REQUESTED] /*/ orders shown in the Updated Unit Forecast have
     been Manufactured by Acusphere, Nycomed may, by notice to Acusphere
     delivered no later than [CONFIDENTIAL TREATMENT REQUESTED] /*/ after
     submission of the MAA or other applicable regulatory filing, suspend (or be
     relieved of, in the event that Governmental Approval is not obtained), its
     obligation to supply rolling forecasts and binding orders (and Acusphere's
     obligation to provide Product) until further notice, for a period of up to
     [CONFIDENTIAL TREATMENT REQUESTED] /*/. Acusphere shall not be responsible
     for any subsequent Failure to Supply occurring as a result of such
     suspension, and no such Failure to Supply shall trigger any of the rights
     of Nycomed provided pursuant to Section 6.06 hereof.

          (c) Purchase orders shall be given on a non-cancelable basis at least
     [CONFIDENTIAL TREATMENT REQUESTED] /*/ prior to the proposed shipment date
     (hereinafter referred to as "Binding Purchase Orders"). Acusphere shall
     confirm the shipment instructions and delivery times for such Binding
     Purchase Order to Nycomed or as otherwise directed by Nycomed. Acusphere
     shall be obligated to accept Binding Purchase Orders with respect to any
     month only to the extent provided in Section 6.05, but, subject to Section
     6.05, Acusphere shall use all reasonable efforts to accept and fill any
     Purchase Orders which provide lead time of at least [CONFIDENTIAL TREATMENT
     REQUESTED] /*/, although Acusphere shall not be obligated to do so.
     Binding Purchase Orders shall specify any special quality requirements for
     any of the Jurisdictions in the Territory. If there is any conflict between
     the terms of a Binding Purchase Order and the terms of this Agreement, the
     terms of this Agreement shall govern, unless Acusphere and Nycomed have
     otherwise expressly agreed in writing.

                                  ARTICLE VIII
                       WARRANTY, REJECTION AND INSPECTIONS

     Section 8.01. ACUSPHERE WARRANTY AND SHELF-LIFE.

     Acusphere represents and warrants to Nycomed that (i) the Product delivered
by Acusphere, or a Third Party Manufacturing on behalf of Acusphere, pursuant to
this Agreement shall comply with the Specifications, the Bulk Packaging
Specifications and Applicable Laws at the date of receipt by Nycomed at its
facility or such other facility as may be designated by Nycomed; (ii) the
Product to be delivered by Acusphere, or a Third Party Manufacturing on behalf
of Acusphere, for sale in the Territory is not adulterated or misbranded under
Applicable Laws in the Territory at the date of receipt by Nycomed; (iii) at the
time of Manufacture by Acusphere, or a Third Party Manufacturing on behalf of
Acusphere, and receipt by Nycomed the Product will be free from any defects in
title, liens and encumbrances and Nycomed shall receive good and marketable
title to the Product; (iv) at the date of Manufacture Acusphere, or a Third
Party Manufacturing on behalf of Acusphere, will have the Governmental Approvals
required to Manufacture and label the Product; (v) the Product will be delivered
by Acusphere, or a Third Party Manufacturing on behalf of Acusphere, to Nycomed
with a remaining shelf-life equal to [CONFIDENTIAL TREATMENT REQUESTED] /*/,
provided that the applicable Governmental Authorities have established a shelf
life of at least [CONFIDENTIAL TREATMENT REQUESTED] /*/, and, equal to
[CONFIDENTIAL TREATMENT

                                       37
<Page>

REQUESTED] /*/ if the applicable Governmental Authorities have established a
shelf life of [CONFIDENTIAL TREATMENT REQUESTED] /*/ (such shelf-life to be
described in the Specifications); and (vi) for the shelf-life of the Products
that the Product is free of defects and any outside contaminants. Products not
conforming to the requirements of this Section 8.01 shall be considered
non-conforming, and hereinafter be referred to as "Non-Conforming Product" or
"Non-Conformity". Notwithstanding the foregoing, Acusphere shall use best
efforts at all times to provide Nycomed with Product with at least [CONFIDENTIAL
TREATMENT REQUESTED] /*/ of remaining shelf-life, including allocating any such
available Product to Nycomed in priority to Acusphere and other customers.

     EXCEPT AS OTHERWISE SET FORTH HEREIN, ACUSPHERE MAKES NO OTHER WARRANTIES
OF ANY OTHER KIND, INCLUDING BUT NOT LIMITED TO ANY WARRANTY OF MERCHANTABILITY
OR FITNESS OF THE PRODUCT FOR ANY PURPOSE, AND ACUSPHERE EXPRESSLY DISCLAIMS ANY
SUCH OTHER WARRANTIES WITH RESPECT TO THE PRODUCT, EITHER EXPRESS OR IMPLIED.

     Section 8.02. REJECTION OF NON-CONFORMING PRODUCT.

     Nycomed shall have sixty (60) days after the receipt at Nycomed's final
destination of any shipment to determine whether a Product is Non-Conforming,
except for hidden defects. A "hidden defect" shall mean a non-specified quality
attribute of a single batch defect in the Product which is not discovered by
Nycomed during its release testing of the Product as such testing is described
in the Specifications. If testing of such Shipment using validated assays shows
a Non-Conforming Product, Nycomed may return the entire Shipment, or any portion
thereof, to Acusphere at Acusphere's expense within a reasonable time following
the above described testing, provided that notice of Non-Conformity is received
by Acusphere from Nycomed within sixty (60) days of Nycomed's receipt of said
Shipment, except for hidden defects. Nycomed shall have the right to request
that Acusphere provide to Nycomed, within sixty (60) days after such notice is
received by it, Product that is free from such Non-Conformity or to promptly
provide Nycomed with full credit for the Purchase Price paid by Nycomed for the
returned Product. In case of a hidden defect, Nycomed shall notify Acusphere
within sixty (60) days after discovery of such hidden defect, and Nycomed shall
have the right to request that Acusphere provide to Nycomed, within sixty (60)
days after a notice concerning a hidden defect is received by it, Product that
are free from any Non-Conformity, or to promptly provide Nycomed with full
credit for the Purchase Price paid by Nycomed for the returned Product. In
either case the cost of freight and handling to return or replace the returned
Product shall be at the expense of Acusphere. If Nycomed does not notify
Acusphere of the Non-Conformity of the Product within sixty (60) days of receipt
of said Shipment, the Product shall be deemed to be free from any
Non-Conformity, except for hidden defects. Notwithstanding anything in this
Agreement to the contrary, the Parties may agree to a return of the Product or
an adjustment in the Purchase Price in the event of any failure or defect in the
Product. Should there be a discrepancy between Nycomed's test results and the
results of testing performed by Acusphere, the Parties agree to first review the
assay procedures and data in good faith, but such discrepancies shall be finally
resolved by testing performed by an independent Third Party mutually agreed upon
by Nycomed and Acusphere. The costs of such testing shall be borne by the Party
against whom the discrepancy is resolved. In the event Product has been
previously returned to Acusphere and an independent Third Party determines that
the Product is free from

                                       38
<Page>

any Non-Conformity, Nycomed shall be responsible for all costs associated with
the return. Notwithstanding anything in this Agreement to the contrary,
Acusphere shall not be responsible for any costs associated with return or
replacement of Product if the Non-Conformity is due to Nycomed having shipped or
stored Product otherwise than in accordance with conditions specified by
Acusphere and in compliance with the Governmental Approvals and Applicable Laws.

     Section 8.03. NYCOMED INSPECTIONS.

     Acusphere shall upon reasonable (but not less than ten (10) business days)
prior written notice by Nycomed and during normal business hours, allow Nycomed
and cause any sub-contractors to allow Nycomed, to inspect and audit Acusphere's
facilities, the facilities of Acusphere's sub-contractors used to Manufacture
the Product, twice annually, to confirm that the facilities and the equipment,
personnel and operating and testing procedures used by Acusphere and Acusphere's
subcontractor(s) in the Manufacture, testing, storage and distribution of the
Product are in compliance with Applicable Laws and the Governmental Approvals;
provided that such inspection does not interfere with Acusphere's or Acusphere's
sub-contractor(s)' normal operations or cause Acusphere or its sub-contractor(s)
to violate or be in breach of any confidentiality agreements with any Third
Party pertaining to other products.

                                   ARTICLE IX

                              REGULATORY COMPLIANCE

     Section 9.01. MARKETING AUTHORIZATION HOLDER.

     Unless otherwise required by Applicable Laws and subject to the provisions
of this Agreement, Nycomed or Affiliates of Nycomed shall be the holders of all
Marketing Authorizations for each Jurisdiction in the Territory during the term
of this Agreement. Each Party agrees that neither it nor its Affiliates or
Partners will do anything to adversely affect a Marketing Authorization.

     Section 9.02.  COMPILATION OF DOSSIER.

     (a)  Acusphere shall provide Nycomed with reasonable access, on reasonable
notice from Nycomed, to all scientific documentation and Product data (in eCTD
format), including stability data, necessary for the compilation of a Dossier
capable of obtaining Governmental Approval for the Product in the Territory
and/or necessary in connection with any application for the initiation of
clinical trials in respect of the Product with the Competent Authorities
(hereinafter referred to as "Data"). Acusphere shall collate and deliver such
Data to Nycomed from time to time at Nycomed's request, including partial
submissions prior to compilation of all Data necessary for approval in the
United States, provided that such requirements do not interfere with Acusphere's
efforts to finalize its submission of its New Drug Application ("NDA") relating
to the Product with the FDA. Acusphere shall provide all available Data to
Nycomed as promptly as is practicable, but in any case within 10 business days
after submission of its NDA to the FDA.

                                       39
<Page>

     (b)  In respect of all clinical trials and Product data effected or created
by Acusphere, Acusphere undertakes that the same will be performed in a
competent and professional manner, consistent with the current state of clinical
research and current Good Clinical Practices acceptable to the EMEA and in
particular in substantial compliance with:

          (i)        all applicable statutes, rules and regulations including,
                     the Declaration of Helsinki; and

          (ii)       any protocol for a clinical trial;

          (iii)      the requirements of any applicable independent ethics
                     committee; and

          (iv)       such other procedures required to satisfy standards or
                     requirements of the EMEA or any other Competent Authority.

     Section 9.03. MARKETING AUTHORIZATIONS.

     Nycomed agrees, at its sole cost and expense, to apply for and maintain the
Marketing Authorizations throughout the Term of this Agreement, including
obtaining any variations or renewals thereof. Nycomed agrees that it will file
the first MAA as promptly as practicable, but in any event within [CONFIDENTIAL
TREATMENT REQUESTED] /*/ after delivery by Acusphere of all required Data as
provided in Section 9.02 above; provided that if the Intellectual Property
Strategy has not resulted in outcomes reasonably satisfactory to Nycomed at such
time, Nycomed may delay its filing for up to an additional [CONFIDENTIAL
TREATMENT REQUESTED] /*/ after such delivery; and further provided that if an
additional clinical trial or additional stability testing is required to file an
MAA for the Product in the Territory, Nycomed may delay its filing for as long
as is necessary to conduct and complete such trial or testing, so long as
Nycomed uses diligent efforts to pursue such trial or test. Notwithstanding any
other provision of this Agreement describing specific costs or expenses to be
borne by Nycomed, the Parties agree that Nycomed shall be responsible for the
payment of all costs and expenses that are necessary to maintain the Marketing
Authorizations in the Territory.

     Section 9.04. INTERACTION WITH COMPETENT AUTHORITIES.

After execution of this Agreement, each Party shall provide to the other Party a
copy of any significant correspondence regarding the Product in the Territory
that it submits to or receives from Competent Authorities and/or the FDA, within
ten (10) days of submission or receipt, as the case may be.

     Section 9.05. ADVERSE DRUG EVENT REPORTING AND PHASE IV SURVEILLANCE.

          (a) The Parties shall establish and maintain a system for exchanging
     safety information on the Product. This system shall enable both Parties to
     meet the safety regulatory requirements imposed by authorities both locally
     and internationally and to follow current international guidelines and
     standards in pharmacovigilance.

          (b) Nycomed will provide a full system for pharmacovigilance in
     accordance with the EU legislation on Pharmacovigilance for Centrally
     Authorised Products

                                       40
<Page>

     (London 15 April 1997 CPMP/183/97) including the Qualified Person for
     Pharmacovigilance as required by the EU legislation (Directive 75/319/EC,
     chapter Va 20 May 1997 as amended). Nycomed will also prepare Periodic
     Safety Updates (ICH format) ("PSUR") and maintain a Company Core Safety
     Information Sheet ("CCSI") for EU.

          (c) During the European Development Program of the Product Nycomed
     will hold the database for reporting of Suspected Unexpected Serious
     Adverse Reactions ("SUSARs") and prepare Annual Safety Reports according to
     the EU Council of Directive 2001/20/EC.

          (d) Any clinical and pre-clinical safety data (Investigator Brochures
     and clinical and pre-clinical reports on the Product) held by Acusphere
     should be provided to Nycomed as reference documents to evaluate the safety
     data to be collected in the pre-marketing development program. Nycomed
     shall provide Acusphere with any clinical or pre-clinical data resulting
     from studies conducted by or on behalf of Nycomed.

          (e) A copy of all expedited Individual Case Safety Reports ("ICSRs")
     and SUSARs annual safety reports and PSURs will be forwarded to the
     Acusphere. A detailed pharmacovigilance agreement between Nycomed and
     Acusphere shall be established at least 3 months prior to the date on which
     Acusphere or any Partner of Acusphere requires information on pre- or post
     marketing safety data for regulatory purposes.

     Section 9.06. COMMERCIAL SALE; TESTING AND REPORTING.

     Notwithstanding the generality of Section 9.02 above, if, after the date of
First Commercial Sale in any Jurisdiction, a Competent Authority in the
Territory requires additional testing, modification or communication related to
approved indications of the Product, then the Parties shall design and Nycomed
shall implement any such testing, modification or communication as shall be
mutually agreed upon by the Parties, provided that Nycomed shall be solely
responsible for all costs associated with such testing, modification or
communication.

     Section 9.07. COMPLIANCE.

     Nycomed and Acusphere shall comply with all Applicable Laws within the
Territory as set forth in this Agreement, including the provision of information
by Nycomed and Acusphere to each other necessary for Acusphere and Nycomed to
comply with any applicable reporting requirements. Each Party shall promptly
notify the other Party of any comments, responses or notices received from, or
inspections by, the FDA, or other applicable Competent Authorities, which relate
to or may impact the Product or the Manufacture of the Product or the sales and
marketing of the Product, and shall promptly inform the other Party of any
responses to such comments, responses, notices or inspections and the resolution
of any issue raised by the FDA or other Competent Authorities.

     Section 9.08. QUALITY AGREEMENT.

     The details of the Parties' responsibilities in connection with the quality
issues of this

                                       41
<Page>

Agreement shall be set out in a separate quality agreement to be entered into
between the Parties; provided that in case of any conflict between such
agreement and this Agreement, the terms of this Agreement shall govern. However,
to the extent that the Parties amend specific terms of the quality agreement
after the Effective Date hereof, the new terms shall govern, provided that
changes are made in writing and by persons authorized to sign on behalf of the
relevant Party.

                                    ARTICLE X

                             PATENTS AND TRADEMARKS

     Section 10.01. MAINTENANCE AND IMPROVEMENT OF PATENTS AND MARKS.

          (a) With respect to matters covered by the Intellectual Property
     Strategy, Acusphere shall use all commercially reasonable efforts to carry
     out the steps set forth in the Intellectual Property Strategy.
     Notwithstanding anything to the contrary contained in this Article X or
     anywhere else in this Agreement, with respect to matters covered by the
     Intellectual Property Strategy, Acusphere's sole obligation shall be to use
     all commercially reasonable efforts to carry out such steps.

          (b) Acusphere shall, at Acusphere's expense, ensure, maintain,
     improve, prosecute, defend and protect the Acusphere Patent Rights and the
     Marks in all of the Jurisdictions in the Territory, including but not
     limited to obtaining new patents for improvements, developments, spin-offs
     and other relevant technologies/know-how related to the Products; provided
     that with respect to Secondary Jurisdictions, Acusphere shall be obligated
     to take such steps only if it is commercially reasonable in light of the
     actual and anticipated sales of Product in such Jurisdiction and the
     strategic effect of such Jurisdiction on the rest of the Territory, after
     consultation with Nycomed. If Acusphere develops additional Acusphere
     Patent Rights in the Territory, it shall so notify Nycomed and the Parties
     shall amend Exhibit A to this Agreement to reflect such additional Patent
     Rights. Upon written request by Acusphere, and at Acusphere's cost, Nycomed
     shall provide such reasonable assistance as may be necessary to enable
     Acusphere to comply with the administrative formalities necessary to
     maintain the Acusphere Patent Rights and the Marks and to prosecute and
     obtain new patents related thereto. Nycomed shall, at Nycomed's expense,
     maintain and protect any trademark, logo, design and/or trade dress owned
     by Nycomed used in relation to the Product to the extent commercially
     reasonable.

     Section 10.02. PROSECUTION OF INFRINGEMENT.

          (a) During the Term, each Party shall give prompt notice to the other
     of any Third Party act which may infringe the Acusphere Patent Rights or
     the Marks in the Territory and shall cooperate with each other to terminate
     such infringement without litigation. Acusphere shall have the right and
     obligation, at its sole expense, to enforce Acusphere Patent Rights in the
     Territory; provided that in Secondary Jurisdictions, Acusphere shall be
     required to bring legal action against an infringer only if it is
     commercially reasonable to do so in light of the actual and anticipated
     sales of Product in such Jurisdiction and the strategic effect of such
     Jurisdiction on the rest of the

                                       42
<Page>

     Territory, after consultation with Nycomed. Nycomed shall provide such
     assistance and cooperation to Acusphere as may be reasonable and necessary
     to successfully prosecute any action against Third Party infringement at
     Acusphere's expense and may deduct the expenses thereof from any amounts
     payable to Acusphere under this Agreement.

          (b) In the event Acusphere fails, to the extent required by the
     preceding paragraph, to institute proceedings against any Third Party
     infringement of the Acusphere Patent Rights and/or the Marks within ninety
     (90) days after notice given by either Party to the other of said Third
     Party infringement, Nycomed may take such action as it deems appropriate,
     including without limitation, the filing of a lawsuit against such Third
     Party. In such event Nycomed shall be entitled to 100% of any damage award
     or other compensation received as a result of such action. Acusphere will
     provide such assistance and cooperation to Nycomed as may be necessary, at
     Acusphere's expense. In such event, the amount of Royalties payable by
     Nycomed on Net Sales in the affected Jurisdiction or Jurisdictions shall be
     reduced to the Technology Access and Trademark Usage Fee.

          (c) Notwithstanding the foregoing, neither Party may settle an action
     or proceeding against an infringer related to the Acusphere Patent Rights
     or the Marks, without the written consent of the other Party, if such
     settlement involves payment of damages by such other Party or the grant of
     a license or other right to market product covered by the Acusphere Patent
     Rights or to use the Marks.

                                   ARTICLE XI

                                 CONFIDENTIALITY

     Section 11.01. CONFIDENTIALITY.

     During the Term and for a period of five (5) years thereafter, each Party
shall maintain all Confidential Information of the other Party as confidential
and shall not disclose any such Confidential Information to any Third Party or
use any such Confidential Information for any purpose, except (a) as expressly
authorized by this Agreement, (b) as required by law, rule, regulation or court
order (provided that the disclosing Party shall first notify the other Party and
shall use all commercially reasonable efforts to obtain confidential treatment
of any such information required to be disclosed), or (c) to its Affiliates,
employees, agents, consultants and other representatives to accomplish the
purposes of this Agreement, so long as such persons are under an obligation of
confidentiality no less stringent than as set forth herein. Each Party may use
such Confidential Information only to the extent required to accomplish the
purposes of this Agreement. Each Party shall use at least the same standard of
care as it uses to protect its own Confidential Information to ensure that its
Affiliates, employees, agents, consultants and other representatives do not
disclose or make any unauthorized use of the other Party's Confidential
Information. Each Party shall promptly notify the other Party upon discovery of
any unauthorized use or disclosure of the other Party's Confidential
Information.

                                       43
<Page>

     Section 11.02. DISCLOSURE OF AGREEMENT.

     Neither Party shall release to any Third Party or publish in any way any
non-public information with respect to the terms of this Agreement without the
prior written consent of the other Party, which consent shall not be
unreasonably withheld, except for the disclosure by a Party of the terms of this
Agreement as may be required by law or except for disclosure to lenders,
investment bankers and other financial institutions of its choice solely for
purposes of financing the business operations of such Party and to potential
merger partners; provided such Party uses reasonable efforts to obtain a signed
confidentiality agreement with any such financial institution with respect to
such information on terms substantially similar to those contained in this
Article XI and except as provided in Section 19.10. For the avoidance of doubt,
nothing in this Section 11.02 shall permit either Party to disclose any
Confidential Information of the other (including without limitation information
relating to technology or manufacturing costs) without such Party's prior
written consent. Nothing contained in this Agreement shall prohibit either Party
from filing this Agreement as required by the rules and regulations of the
Securities and Exchange Commission, national securities exchanges (including
those located in countries outside of the United States) or the Nasdaq Stock
Market; provided the disclosing Party uses reasonable efforts to disclose only
the minimum information required to be disclosed in order to comply with such
requirements, including requesting confidential treatment of this Agreement and
filing this Agreement in redacted form.

                                   ARTICLE XII

                        ACUSPHERE'S OPTION TO MARKET THE
                       PRODUCT UNDER CERTAIN CIRCUMSTANCES

     Section 12.01. CO-MARKETING RIGHTS.

     If Nycomed should fail (through no fault of Acusphere and without Good
Reason) to achieve, in any Primary Jurisdiction or in the Secondary
Jurisdictions taken as a whole, the Minimum Sales Target in such Primary
Jurisdiction or the aggregate Minimum Sales Target for the Secondary
Jurisdictions as set forth in the Sales Forecast then, and only if either of
such events occur [CONFIDENTIAL TREATMENT REQUESTED] /*/, Acusphere shall have
the right and option, exercisable in its sole discretion, by written notice to
that effect delivered by Acusphere to Nycomed within sixty (60) days after said
events occur, to co-market the Product in such Primary Jurisdiction or in each
particular Secondary Jurisdiction in which Nycomed has failed to meet its
Minimum Sales Target, either by itself or in conjunction with another entity. If
Acusphere exercises its right to co-market the Product in such Jurisdiction the
following shall occur, to the extent allowed by Applicable Laws: (i) the license
granted to Nycomed by Acusphere under Section 3.02 shall thereafter be deemed to
be a non-exclusive license within such Jurisdiction ([CONFIDENTIAL TREATMENT
REQUESTED] /*/); (ii) Nycomed shall grant and hereby does grant to Acusphere an
irrevocable, non-exclusive, royalty-free license, with the right to sublicense,
to use the Clinical Documentation, the Results and the Marketing Authorizations
and make any filings required by Nycomed with the Competent Authorities, to the
extent legally permissible, in connection with such activities and only for the
Jurisdiction in question; (iii) Nycomed shall cooperate with Acusphere in
obtaining the necessary Marketing Authorizations in a timely manner, at
Acusphere's expense; (iv) Acusphere will be solely

                                       44
<Page>

responsible for its expenses related to marketing the Product in such
Jurisdiction and Acusphere will retain all revenues from Product that it or its
sub-licensees sell in such Jurisdiction; (v) subject to and in compliance with
all Applicable Laws, Acusphere will use all commercially reasonable efforts to
restrict the sale of such Product by its sub-licensee outside of said
Jurisdiction; and (vi) the Steering Committee will be deemed to disregard its
function with respect to the Jurisdiction in which Acusphere exercises its right
to co-market the Product. If Acusphere decides to use its co-marketing rights
according to this Section 12.01, Acusphere agrees to market the Product under a
brand name that is different from the Marks or other trademark used by Nycomed
to market the Product. For purposes of this Agreement "Good Reason" shall mean
the occurrence of unforeseen changes in government regulations, reimbursement
conditions or competitive conditions in a particular Jurisdiction which Nycomed
may reasonably demonstrate to be outside the control or influence Nycomed after
their use of all commercially reasonable efforts.

                                  ARTICLE XIII

                         REPRESENTATIONS AND WARRANTIES

     Section 13.01. CORPORATE POWER.

     As of the Effective Date, each Party hereby represents and warrants that
such Party is duly organized and validly existing under the laws of the
jurisdiction of its incorporation and has full power and authority to enter into
this Agreement and the transactions contemplated hereby and to carry out the
provisions hereof.

     Section 13.02. DUE AUTHORIZATION.

     As of the Effective Date, each Party hereby represents and warrants that
such Party is duly authorized to execute and deliver this Agreement and to
perform its obligations hereunder.

     Section 13.03. BINDING OBLIGATION.

     As of the Effective Date, each Party hereby represents and warrants that
this Agreement is a legal and valid obligation binding upon it and is
enforceable in accordance with its terms, except that the enforcement of the
rights and remedies created hereby is subject to bankruptcy, insolvency,
reorganization and similar laws of general application affecting the rights and
remedies of creditors and that the availability of the remedy of specific
performance or of injunctive relief is subject to the discretion of the court
before which any proceeding therefore may be brought. As of the Effective Date,
the execution, delivery and performance of this Agreement by such Party does not
conflict with any agreement, instrument or understanding, oral or written, to
which it is a party or by which it may be bound, nor violate any law or
regulation of any court, governmental body or administrative or other agency
having authority over it.

     Section 13.04. LEGAL PROCEEDINGS.

     As of the Effective Date, each Party hereby represents and warrants to the
other Party that there is no action, suit or proceeding pending against or
affecting, or, to the knowledge of either

                                       45
<Page>

Party, threatened against or affecting that Party, or any of its assets, before
any court or arbitrator or any governmental body, agency or official that would,
if decided against either Party, have a material adverse impact on the business,
properties, assets, liabilities or financial condition of that Party (that are
not already reflected in that Party's respective financial statements that, with
respect to Acusphere, have been filed with the Securities and Exchange
Commission or, with respect to Nycomed, have been disclosed to the public) and
which would have a material adverse effect on that Party's ability to consummate
the transactions contemplated by this Agreement.

     Section 13.05. ABSENCE OF CERTAIN CHANGES

     As of the Effective Date, each Party represents and warrants to the other
that since March 30, 2004 there has been no change or development not disclosed
to the other Party that has had or could reasonably be expected to have, either
individually or in the aggregate, a material adverse effect on the Parties'
respective abilities to fulfill their obligation under the Agreement as related
to the business, assets, liabilities, properties, financial condition or results
of operation of such Party and its Affiliates, taken as a whole.

     Section 13.06. LIMITATION OF LIABILITY.

     NEITHER PARTY SHALL BE ENTITLED TO RECOVER FROM THE OTHER PARTY ANY
SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES IN CONNECTION WITH THIS AGREEMENT
OR ANY LICENSE GRANTED HEREUNDER, EXCEPT AS OTHERWISE SET FORTH IN ARTICLE XIV,
AND EXCEPT THAT CONSEQUENTIAL DAMAGES MAY BE PAYABLE IN THE EVENT OF A BREACH OF
A PARTY'S OBLIGATIONS HEREUNDER DUE TO SUCH PARTY'S GROSS NEGLIGENCE OR WILLFUL
MISCONDUCT.

                                   ARTICLE XIV

                                 INDEMNIFICATION

     Section 14.01. INTELLECTUAL PROPERTY INDEMNITY.

     (a)  Acusphere shall defend, at its expense, Nycomed from and against any
claims by Third Parties alleging that the Product infringes any patent or
trademark of any Third Party within the Territory, and shall indemnify Nycomed
against all damages payable as part of a final judgement or settlement thereof.
The indemnification obligation of this Section 14.01 shall not apply to any
claim arising out of (i) the combination of the Product with other products not
provided by Acusphere, to the extent that alleged infringement would have been
avoided absent such combination, or (ii) the modification of the Product by
anyone other than Acusphere or a party acting on Acusphere's behalf, to the
extent that alleged infringement would have been avoided absent such
modification.

     (b)  The obligations of Acusphere set forth in Paragraph (a) above are
subject to the conditions precedent that: (i) Nycomed promptly notifies
Acusphere in writing of any such suit or proceeding, (ii) Nycomed provides
Acusphere with sole control over the defense or settlement of such suit or
proceeding (although Nycomed may participate in such suit or proceeding at its
own cost and expense) or Nycomed itself takes control over such defense or
settlement should

                                       46
<Page>

Acusphere fail to do so, and (iii) Nycomed provides reasonable information and
assistance in the defense and/or settlement of any such claim or action.
Acusphere will pay for all damages, reasonable attorney's fees and costs finally
awarded against Nycomed, but will not be responsible for any costs, expenses or
compromise incurred or made by Nycomed without Acusphere's prior written
consent.

     (c)  The provisions of this Section 14.01, the Intellectual Property
Strategy, and Section 18.03(b), (c) and (d) and Section 18.06 set forth the
Parties' entire agreement regarding remedies available to Nycomed in the event
of infringement of Third Party intellectual property and shall provide Nycomed's
sole and exclusive remedy in the event of any infringement claim or demand
asserted by a Third Party. In particular, prior to the first Acceptance for
Filing of the Product, Nycomed's sole remedy for any failure by Acusphere to use
all commercially reasonable efforts to carry out the Intellectual Property
Strategy shall be to terminate this Agreement under Section 18.03(b) and claim
monies as provided therein.

     (d)  In no event shall Acusphere be responsible to Nycomed under this
Section 14.01 for paying any amount in excess of [CONFIDENTIAL TREATMENT
REQUESTED] /*/, whether as to damages, in settlement, or as costs and expenses.

     Section 14.02. PRODUCT LIABILITY AND INSURANCE.

     Acusphere agrees to indemnify and hold Nycomed and its Affiliates,
employees, officers and directors harmless from any and all liabilities
(including any claim for product liability or any claim for injury or death with
respect to the Product), damages, costs or expenses, including internal costs
and including reasonable attorneys fees and expenses, as well as damages payable
as part of a final judgment or settlement of a claim (collectively "Losses")
resulting from any threatened or pending lawsuit, action or investigation,
private or governmental, arising from the Manufacture of any Product
Manufactured by Acusphere, or Manufactured by a Third Party on behalf of
Acusphere, hereunder, or arising as the result of shipment of the Product by
Acusphere to Nycomed. Nycomed agrees to indemnify and hold Acusphere harmless
from all Losses resulting from any threatened or pending lawsuit, action or
investigation, private or governmental, arising from the shipping, storage or
handling of the Product after it has been received by Nycomed at its facility or
such other facility as may have been designated by Nycomed as the destination or
its designee, the Manufacture of any Product Manufactured by Nycomed or by a
Third Party on behalf of Nycomed, or from the use or sale of the Product in the
Territory; provided, however, that any such Losses are not due to the
Manufacture of the Product by Acusphere or a Third Party on behalf of Acusphere,
and thus subject to Acusphere's obligation to indemnify and hold Nycomed
harmless. Each Party shall maintain adequate insurance with a financial sound
carrier against any and all such Losses in accordance with Section 17.01 below.

                                       47
<Page>

                                   ARTICLE XV

                                    COVENANTS

     Section 15.01. COVENANT NOT TO LAUNCH COMPETITIVE PRODUCT.

     Nycomed hereby covenants for a period of five (5) years from the First
Commercial Sale of the Product and for any subsequent period in which the
exclusive purchasing arrangement provided for in Section 6.01 has been renewed,
that neither it nor its Affiliates shall out-license, commercialize, market,
sell, distribute or have marketed, have sold or have distributed any Competitive
Product in any Jurisdiction in which Nycomed retains a license granted by
Acusphere under Article III during the Term. Notwithstanding the foregoing, if
Nycomed or any Affiliate acquires an entity or all or substantially all of the
assets of an entity and such entity distributes a Competitive Product or such
assets include a Competitive Product, or if Nycomed is acquired by such entity
(whether by merger, sale of assets or otherwise) Nycomed or its successor shall
be required to notify Acusphere within 30 days after such acquisition whether it
intends to divest itself of such Competitive Product. If it chooses not to
divest the Competitive Product, then Acusphere shall have the right to terminate
this Agreement immediately upon notice to Nycomed or its successor, with the
same effect as a termination under Section 18.02. If Nycomed or its successor
chooses to divest itself of such Competitive Product, it shall use best efforts
to do so within one hundred and twenty (120) days after such notice, and if it
is unsuccessful in so divesting the Competitive Product it shall promptly wind
down all marketing, sales and distribution of such Competitive Product, such
that within 180 days of such notice it shall no longer sell or distribute such
Competitive Product.

     Section 15.02. LIMITATION TO THE TERRITORY.

     Nycomed covenants and agrees that it will not, nor shall it permit its
Affiliates, without the prior written authorization of Acusphere, to the extent
allowed by Applicable Laws: (i) actively promote or actively solicit sale of the
Product or advertise the Product, in any Jurisdiction where Nycomed does not
have a necessary Marketing Authorization or in any country that is not part of
the Territory; (ii) contact the FDA or Competent Authorities or other entity
located outside the Territory about the Product, except as required by
Applicable Laws or as may be necessary or appropriate to exercise its rights or
carry out its obligations as set forth in this Agreement; and (iii) knowingly
sell or distribute for resale the Product purchased hereunder to a Third Party
who intends to sell such Product in a Jurisdiction where Nycomed does not have a
Marketing Authorization, if required, or in any country that is not part of the
Territory, provided that, with respect to both of the foregoing set forth in
this clause (iii), such Jurisdictions are not members of the European Economic
Area and such resale will not have significant effect in the European Economic
Area.

     Section 15.03. MARKETING COMMITMENT.

     Nycomed covenants and agrees that it shall maintain sales and marketing
spending levels in the Territory in a manner consistent with commercially
reasonable marketing efforts.

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<Page>

                                   ARTICLE XVI

                                 PRODUCT RECALL

     Section 16.01. PRODUCT RECALLS OR WITHDRAWAL.

     If at any time or from time to time any Competent Authority of any
Jurisdiction requests a Party to recall the Product or if a voluntary recall of
the Product is contemplated by either Party (collectively, a "Recall"), then the
Party to whom such request is made or the Party contemplating such Recall, as
the case may be, shall immediately notify the other Party. Neither Party shall
carry out a voluntary Recall in the Territory without the prior written approval
of the other Party, which approval shall not be unreasonably withheld,
conditioned or delayed by either Party. Any Recall in the Territory shall be
carried out by Nycomed in as expeditious a manner as reasonably possible to
preserve the goodwill and reputation of the Product and the goodwill and
reputation of the Parties. Nycomed shall in all events be responsible for
conducting any Recall in the Territory, market withdrawals or corrections with
respect to the Product in the Territory. Nycomed shall maintain records of all
sales and distribution of Product and customers sufficient to adequately
administer a Recall, market withdrawal or correction for the period required by
Applicable Law. Acusphere shall be responsible, at its sole cost and expense,
for conducting any Recall outside of the Territory and agrees to notify Nycomed
immediately if a Competent Authority outside of the Territory has requested a
Recall or if Acusphere is contemplating a voluntary Recall outside of the
Territory; provided, however, that any such voluntary Recall shall be subject to
Acusphere's contractual obligations with Third Parties outside the Territory
and, if Acusphere is permitted to exercise discretion under such contractual
obligations, Acusphere shall consider the effect of such voluntary recall on the
marketing and sale of the Product in the Territory.

     Section 16.02. RECALL COSTS.

     Nycomed shall be responsible for conducting any Recall in the Territory and
the cost and expense of a Recall shall be allocated as follows:

          (a) if such Recall shall be due to manufacturer's defect or the
     negligence or the breach by Acusphere of its warranties or obligations
     hereunder or the misconduct of Acusphere, all such costs and expenses shall
     be borne and paid solely by Acusphere and Acusphere will reimburse Nycomed
     for any such costs and expenses paid by Nycomed within thirty (30) days of
     receipt of an invoice for such costs and expenses from Nycomed, and if not
     so paid Nycomed shall have the right to offset such amounts against amounts
     otherwise due by Nycomed to Acusphere hereunder; and

          (b) if such Recall is due to the negligence or misconduct of Nycomed,
     by the breach by Nycomed of its warranties or obligations hereunder or by
     the failure by Nycomed to ensure that Product is shipped and stored under
     appropriate conditions as specified by Acusphere and in accordance with
     Governmental Approvals and Applicable Laws, all such costs and expenses
     shall be borne and paid solely by Nycomed and Nycomed will reimburse
     Acusphere for any such costs and expenses paid by Acusphere

                                       49
<Page>

     within thirty (30) days of receipt of an invoice and appropriate
     documentation for such costs and expenses from Acusphere.

          (c) if such Recall is due to a decision by any Competent Authority
     and/or cannot be considered caused by the negligence or misconduct of
     either Party or by the breach by either Party of its warranties or
     obligations hereunder, all such costs and expenses shall be borne and paid
     in equal parts by Nycomed and Acusphere, in which case the relevant Party
     will reimburse the other Party for any costs and expenses paid by a Party
     within thirty (30) days of receipt of an invoice and appropriate
     documentation for such costs and expenses from such relevant Party.

     Section 16.03. NOTIFICATION OF COMPLAINTS.

     Each Party agrees that throughout the Term of this Agreement, and with
respect to all Product supplied and purchased under this Agreement, after the
termination of this Agreement, it will (i) notify the other Party immediately of
all available information concerning any complaint, product defect reports, and
similar notices received by either Party with respect to the Product, whether or
not determined to be attributable to the Product and (ii) with respect to an
adverse drug event, comply with the provisions of Section 9.05. Nycomed, in
consultation with Acusphere, shall define and implement regulatory compliance
procedures, including, without limitation, action plans and an SOP for product
defect reporting and will handle all product complaints in the Territory. In
connection with any such product complaint Acusphere shall cooperate as
reasonably requested by Nycomed including performing any testing and follow-up
investigations mutually agreed upon by the Parties.

     Section 16.04. NOTIFICATION OF THREATENED ACTION.

     Throughout the duration of this Agreement and with respect to all Product
supplied and purchased under this Agreement, after the termination of this
Agreement, each Party shall immediately notify the other Party of any
information it receives regarding any threatened or pending action, inspection
or communication by or from a concerned Competent Authority which may affect the
safety or efficacy claims of the Product or the continued marketing of the
Product. Upon receipt of such information, the Parties shall consult with each
other in an effort to arrive at a mutually acceptable procedure for taking
appropriate action.

                                  ARTICLE XVII

                                    INSURANCE

     Section 17.01. INSURANCE.

     Each Party shall, at its sole cost and expense, obtain and keep in force
sufficient comprehensive insurance coverage commensurate with its obligations
under this Agreement, including insurance for bodily injury, death and property
damage including product liability coverage, with a minimum (from and after the
date that Product is first Manufactured for commercial sale) of not less than
Fifteen Million Dollars ($15,000,000).

                                       50
<Page>

                                  ARTICLE XVIII

                          TERM; DEFAULT AND TERMINATION

     Section 18.01. TERM.

     This Agreement shall commence as of the Effective Date and shall expire on
a Jurisdiction-by-Jurisdiction basis on the later of the year 2022 or the
expiration of the last applicable Acusphere Patent Right, or any other patents
obtained by Acusphere with regard to the Product, in such Jurisdiction (the
"Term"). Notwithstanding the foregoing, if the Intellectual Property Strategy is
not adopted by the Steering Committee within 60 days after the Effective Date,
this Agreement shall terminate and Acusphere shall promptly thereafter refund to
Nycomed any monies previously paid by Nycomed to Acusphere hereunder.

     Section 18.02. BASIS FOR TERMINATION BY EITHER PARTY.

     Either Party may terminate this Agreement prior to the expiration of the
Term upon the occurrence of any of the following:

          (a) Upon or after the cessation of operations of the other Party or
     the bankruptcy, insolvency, dissolution or winding up of the other Party
     (other than dissolution or winding up for the purposes or reconstruction or
     amalgamation); or

          (b) Upon or after the breach of any material provision of this
     Agreement (including, without limitation, the representation set forth in
     Section 13.05) by the other Party if the breaching Party has not cured such
     breach (if curable) within sixty (60) days after written notice thereof by
     the non-breaching Party.

     Section 18.03. BASIS FOR TERMINATION BY NYCOMED

     Without limiting the generality of Section 18.02 above, and in addition
thereto, Nycomed may terminate this Agreement prior to the expiration of the
Term upon the occurrence of any of the following:

          (a) Upon the failure by Acusphere to provide Nycomed with assistance
     to Manufacture as and when required by Section 6.06 of this Agreement; or

          (b) At any time prior to first MAA submission, if Nycomed reasonably
     believes that the sale and marketing of the Product in the Territory will
     infringe Patent Rights of Third Parties, or if Acusphere has failed in any
     material respect to use all commercially reasonable efforts to carry out
     the Intellectual Property Strategy, or

          (c) For the Territory as a whole or on a Jurisdiction by Jurisdiction
     basis if, at any time within 180 days after receipt of the first
     Governmental Approval in the Territory, Nycomed reasonably believes that
     the sale and marketing of the Product in the Territory will infringe Patent
     Rights of Third Parties, such that in Nycomed's good faith judgement it is
     no longer commercially reasonable to sell the Product in the Territory or a
     particular Jurisdiction on the terms set forth in this Agreement; or

                                       51
<Page>

          (d) For the Territory as a whole or on a Jurisdiction by Jurisdiction
     basis, upon judgement or settlement of any Third Party claim or dispute on
     terms which causes Nycomed to determine that it is no longer commercially
     reasonable to sell the Product in the Territory or a particular
     Jurisdiction on the terms set forth in this Agreement; or

          (e) With immediate effect by notice given on or before (i) 31 December
     2004; or (ii) 30 calendar days after enrollment of the last patient to
     Acusphere's current Phase III clinical trials, if a Phase III Event has
     occurred prior to such time.

     Section 18.04. BASIS FOR TERMINATION BY ACUSPHERE.

     Without limiting the generality of Section 18.02 above, and in addition
thereto, Acusphere may terminate this Agreement prior to the expiration of the
Term upon the occurrence of any of the following:

          (a) Upon the failure by Nycomed to pay any amount due to Acusphere
     hereunder within thirty (30) days from receipt of notice thereof (sent by
     registered letter) from Acusphere;

          (b) At any time prior to first MAA submission, if Acusphere reasonably
     believes that the sale and marketing of the Product in the Territory will
     infringe Patent Rights of Third Parties;

          (c) Upon any purported assignment by Nycomed of its rights hereunder
     in violation of Section 19.02;

          (d) For the Territory as a whole or on a Jurisdiction by Jurisdiction
     basis if, at any time within 180 days after receipt of the first
     Governmental Approval in the Territory, Acusphere reasonably believes that
     the sale and marketing of the Product in the Territory will infringe Patent
     Rights of Third Parties, such that in Acusphere's good faith judgement it
     is no longer commercially reasonable to sell the Product in the Territory
     or a particular Jurisdiction on the terms set forth in this Agreement;

          (e) For the Territory as a whole or on a Jurisdiction by Jurisdiction
     basis, upon judgement or settlement of any Third Party claim or dispute on
     terms which causes Acusphere to determine that it is no longer commercially
     reasonable to sell the Product in the Territory or a particular
     Jurisdiction on the terms set forth in this Agreement;

     Section 18.05. REMEDIES.

     All of the non-breaching Party's remedies shall be cumulative, and the
exercise of one remedy hereunder by the non-defaulting Party shall not be deemed
to be an election of remedies. These remedies shall include the non-breaching
Party's right to sue for damages for such breach without terminating this
Agreement.

                                       52
<Page>

     Section 18.06. EFFECT OF TERMINATION BY NYCOMED.

          (a) Upon termination of this Agreement by Nycomed pursuant to Sections
     18.02 or 18.03(a), at Nycomed's option either

                   (i)     the licenses granted to Nycomed hereunder shall
            terminate and Nycomed shall have no further rights to sell or market
            the Product, but (in the event of a termination by Nycomed under
            Section 18.02 (b) or 18.03(a)) shall have the right to seek damages,
            subject to the limitations set forth in Section 13.06 hereof; or

                   (ii)    the licenses granted to Nycomed hereunder shall
            continue for the remainder of the Term (and if not previously
            exercised pursuant to Section 6.06 (a) the license to Manufacture
            the Product for sale in the Territory set forth therein shall be
            deemed immediately granted), in return for Nycomed's obligation
            to pay an ongoing royalty equivalent to five percent (5%) of Net
            Sales in the Territory and fifty percent (50%) of amounts due as
            milestone payments under Sections 4.03 and 4.04 herein on the
            terms and conditions set forth herein; provided however, that in
            the case of a termination of this Agreement by Nycomed pursuant
            to Section 18.02(b), Acusphere shall, if requested by Nycomed and
            indemnified by Nycomed for any and all Losses arising as a result
            of doing so, continue to supply Nycomed with Product as provided
            under this Agreement until the earlier of thirty (30) months
            after such termination or such date as Nycomed has established
            its own manufacturing facility for the Product;

          (b) Upon termination of this Agreement by Nycomed pursuant to
     Section 18.03(b), (i) Nycomed shall have no right to use any of the
     Acusphere Technology or to use the Marks, and (ii) if Acusphere has
     failed in any material respect to use all commercially reasonable
     efforts to carry out the Intellectual Property Strategy, Acusphere shall
     pay Nycomed an amount, as liquidated damages, the amount previously paid
     by Nycomed to Acusphere pursuant to Sections 2.02(a) and 3.01 of this
     Agreement, which amount may be payable to Acusphere at its option in
     equal annual installments over a three year period, together with
     interest on the unpaid amount at the Prime Rate of Interest.

          (c) Upon termination of this Agreement by Nycomed pursuant to Section
     18.03(c) or (e), (i) Nycomed shall have no right to practice within the
     Acusphere Patent Rights or use any of the Acusphere Technology or to use
     the Marks within the applicable Jurisdiction or Jurisdictions, (ii) Nycomed
     shall pay Acusphere all amounts under Section 2.02(a) attributable to any
     period prior to such termination, and (iii) Nycomed shall grant to
     Acusphere an irrevocable, exclusive, royalty-free license, with the right
     to sublicense, to the Clinical Documentation, the Results and the Marketing
     Authorizations and make any filings required of Nycomed with the Competent
     Authorities to the extent necessary and sufficient to allow Acusphere or
     its designee to market and sell the Product in such Jurisdictions.

                                       53
<Page>

          (d) Upon termination of this Agreement by Nycomed pursuant to Section
     18.03(d) (i) Nycomed shall have no right to practice within the Acusphere
     Patent Rights or use any of the Acusphere Technology or to use the Marks
     within the applicable Jurisdiction or Jurisdictions, and(ii) Nycomed shall
     grant to Acusphere an irrevocable, exclusive, royalty-free license, with
     the right to sublicense, to the Clinical Documentation, the Results and the
     Marketing Authorizations and make any filings required of Nycomed with the
     Competent Authorities to the extent necessary and sufficient to allow
     Acusphere or its designee to market and sell the Product in such
     Jurisdictions.

     Section 18.07. EFFECT OF TERMINATION BY ACUSPHERE

          (a) Upon termination of this Agreement by Acusphere pursuant to
     Sections 18.02 or 18.04(a) or (c), (i) Nycomed shall have no right to
     practice within the Acusphere Patent Rights or use any of the Acusphere
     Technology or to use the Marks, (ii) Nycomed shall pay Acusphere all
     amounts under Section 2.02(a) attributable to any period prior to such
     termination, (iii) Nycomed shall grant to Acusphere an irrevocable,
     exclusive, royalty-free license, with the right to sublicense, to the
     Clinical Documentation, the Results and the Marketing Authorizations and
     make any filings required of Nycomed with the Competent Authorities to the
     extent necessary and sufficient to allow Acusphere or its designee to
     market and sell the Product in the Territory , and (iv) Nycomed's sole
     right with respect to the Product shall be to either destroy remaining
     Product held by it or to sell off the remaining Product over a period of
     six months from the date of such termination. If Nycomed chooses to sell
     off the remaining Product, Nycomed shall:

                         (A) within thirty (30) days of issuance of a notice of
                 termination by any Party, notify Acusphere that it intends to
                 sell off existing inventory of Product as provided in this
                 Agreement;

                         (B) continue to comply with its payment obligations to
                 Acusphere under Article IV;

                         (C) continue to sell off existing inventory of Product
                 for six (6) months after the notice of termination, at prices
                 equivalent to those charged prior to termination of this
                 Agreement, but at the expiration of the six (6) months, destroy
                 all remaining inventory of Product in accordance with
                 Applicable Law,

     If Nycomed notifies Acusphere that Nycomed does not intend to sell off any
     existing inventory of Product, Nycomed shall destroy all remaining
     inventory of Product in accordance with Applicable Law, providing Acusphere
     with proof of destruction in writing sufficient to comply with Applicable
     Laws.

     (b)  Upon termination of this Agreement by Acusphere pursuant to Section
          18.04(b), (d) or (e), at Nycomed's option, one of the following shall
          occur;

                   (i)   the licenses granted to Nycomed hereunder shall
            continue for

                                       54
<Page>

            the remainder of the Term (and if not previously exercised pursuant
            to Section 6.06 (a) the license to Manufacture the Product for sale
            in the Territory set forth therein shall be deemed immediately
            granted), in return for Nycomed's obligation to pay on an ongoing
            basis [CONFIDENTIAL TREATMENT REQUESTED] /*/ , and to pay
            [CONFIDENTIAL TREATMENT REQUESTED] /*/ percent ([CONFIDENTIAL
            TREATMENT REQUESTED] /*/%) of amounts due as milestone payments
            under Sections 4.03 and 4.04 herein.. In such event, Acusphere shall
            no longer have any obligations under Article X or Article XV hereof
            and Acusphere shall, if requested by Nycomed and indemnified by
            Nycomed for any and all Losses arising as a result of doing so,
            continue to supply Nycomed with Product as provided under this
            Agreement until the earlier of [CONFIDENTIAL TREATMENT REQUESTED]
            /*/ after such termination or such date as Nycomed has established
            its own manufacturing facility for the Product; or

                   (ii)  the license granted to Nycomed hereunder shall
            terminate and be of no further force or effect, Nycomed shall be
            entitled to sell off existing inventory as set forth in Section
            18.07 (a) above and Acusphere shall pay Nycomed an amount equal
            to the amount previously paid by Nycomed to Acusphere pursuant to
            Sections 2.02(a) and 3.01 and 4.03 of this Agreement, plus Out of
            Pocket Expenses which amount may be payable by Acusphere at its
            option in equal annual installments over a three year period,
            together with interest on the unpaid amount at the Prime Rate of
            Interest.

     Except as otherwise provided in this Agreement, the obligations and rights
of the Parties under Sections 3.04, 13.06 and Articles XI, XVI and XIX and this
Article XVIII shall survive expiration or termination of this Agreement.

     Within thirty (30) days following the expiration or termination of this
Agreement, each Party shall return to the other Party, or destroy, upon the
written request of the other Party, any and all Confidential Information of the
other Party in its possession (except one copy for legal records only) and upon
a Party's request, such destruction (or delivery) shall be confirmed in writing
to such Party by a responsible officer of the other Party.

     Section 18.08. LICENSE FOLLOWING EXPIRATION.

     After expiration of the Royalty Term, Acusphere shall continue to sell the
Product to Nycomed upon terms mutually agreeable to the Parties pursuant to a
separate supply agreement to be negotiated in good faith between the Parties.

                                   ARTICLE XIX

                                  MISCELLANEOUS

     Section 19.01. NO-SOLICITATION.

     During the Term of this Agreement, neither Party nor its Affiliates
(collectively, the "Initiating Group") shall, directly or through its
representatives, solicit for employment or hire any officer, director or
employee of the other Party or its subsidiaries or controlled Affiliates
(collectively, the "Other Group") with whom the Initiating Group has contact in
connection with, or who otherwise is known by the Initiating Group to
participate in, the transactions

                                       55
<Page>

contemplated by this Agreement. The Initiating Group shall not be precluded from
hiring any such person who has been terminated by the Other Group prior to
commencement of employment discussions between such person and the Initiating
Group or its representatives. "Solicitation" shall not include any generalized
public advertisement or any other solicitation by the Initiating Group or its
representatives that is not specifically directed toward any such employee of
the Other Group or toward any group of such employees of the Other Group.

     Section 19.02. ASSIGNMENT.

     Except as expressly provided hereunder, neither this Agreement nor any
rights or obligations hereunder may be assigned or otherwise transferred by
either Party without the prior written consent of the other Party (which consent
shall not be unreasonably withheld); provided, however, that either Party may
assign this Agreement and its rights and obligations hereunder without the other
Party's consent (a) in connection with the transfer or sale of all or
substantially all of the business of such Party to a Third Party, whether by
merger, sale of stock, sale of assets or otherwise (a "Company Sale
Transaction"), or (b) to any Affiliate; provided that no such assignment to an
Affiliate shall relieve the assigning Party of its responsibilities for
performance of its obligations under this Agreement. Notwithstanding the
foregoing, at any time after Nycomed has exercised its manufacturing rights
under Section 6.06 hereof, Nycomed shall not be entitled to assign its rights
hereunder in connection with a Company Sale Transaction to a Manufacturing
Competitor without the prior written consent of Acusphere, which consent shall
not be unreasonably withheld unless, prior to the transfer of Nycomed's rights
under this Agreement, Nycomed transfers the manufacturing rights from Nycomed
back to Acusphere, together with all of Acusphere's Confidential Information
relating to Manufacture of the Product (it being understood that the Parties
will each use all commercially reasonable efforts to accomplish the transfer
back of manufacturing rights in a timely manner), in which case; Acusphere's
consent shall not be required. The rights and obligations of the Parties under
this Agreement shall be binding upon and inure to the benefit of the successors
and permitted assigns of the Parties. Any assignment not in accordance with this
Agreement shall be void.

     Section 19.03. FORCE MAJEURE.

     Neither Party shall be held liable or responsible to the other Party nor be
deemed to have defaulted under or breached this Agreement for failure or delay
in fulfilling or performing any term of this Agreement to the extent and for as
long as such failure or delay is caused by or results from causes beyond the
reasonable control of the affected Party, including, but not limited to, fire,
floods, embargoes, war, acts of war (whether war be declared or not), acts of
terrorism, insurrections, riots, civil commotions, strikes, lockouts or other
labor disturbances, acts of God or acts, omissions or delays in acting by any
governmental authority or the other Party, or for any other reason which is
completely beyond the control of the Party (collectively a "Force Majeure");
provided that the Party whose performance is delayed or prevented shall continue
to use good faith diligent efforts to mitigate, avoid or end such delay or
failure in performance as soon as practicable. If the Force Majeure subsists for
more than 90 days, the Parties shall discuss in good faith how to resolve the
situation.

                                       56
<Page>

     Section 19.04. GOVERNING LAW; DISPUTE RESOLUTION.

     This Agreement shall be governed by, and construed and enforced in
accordance with, the laws of the Commonwealth of Massachusetts, USA, except that
no conflict of laws provision shall be applied to make the laws of any other
jurisdiction applicable to this Agreement. The Parties agree to perform the
terms of this Agreement in good faith, and to attempt to resolve any
controversy, claim or dispute arising hereunder in good faith and solely in
accordance with this Section 19.04. If either Party believes that a dispute
has arisen under this Agreement that has not been satisfactorily resolved by the
Steering Committee after at least 30 days of discussion shall so notify the
other Party. Upon such notification, the Chief Executive Officers of both
Parties shall then attempt to resolve the dispute in good faith for a period of
an additional 60 days. If the dispute is not resolved as a result of such
discussions, it shall be submitted to binding arbitration in Boston,
Massachusetts, U.S.A. to be conducted in accordance with the Arbitration Rules
of the American Arbitration Association ("AAA"); provided however, that nothing
in this Section 19.04 shall be construed to preclude either Party from seeking
provisional remedies, including, but not limited to, temporary restraining
orders and preliminary injunctions, from any court of competent jurisdiction, in
order to protect its rights pending arbitration, but such preliminary relief
shall not be sought as a means of avoiding arbitration. Any arbitration
hereunder shall be submitted to an arbitration tribunal made up of three (3)
members experienced in or knowledgeable of the biotechnology and pharmaceutical
industries, one of whom shall be selected by Nycomed, one of whom shall be
selected by Acusphere, and one of whom shall be selected by the other two
arbitrators. All arbitration proceedings shall be conducted in English. The
order or award of the arbitrators shall be final and may be enforced in any
court of competent jurisdiction in the Territory or the United States. The
prevailing Party in any legal or arbitration action brought by one Party against
the other shall be entitled, in addition to any other rights and remedies it may
have, to reimbursement for its expenses incurred thereby, including court costs
and reasonable attorneys' fees. The Parties shall have the right of limited
prehearing discovery, including (i) exchange of witness lists, (ii) exchange of
documentary evidence and reasonably related documents, (iii) written
interrogatories, and (iv) subject to the reasonable discretion of the
arbitrators and upon good cause shown depositions under oath of any witnesses
who are to be called to testify at the arbitration hearing. As soon as the
discovery is concluded, the arbitrators shall hold a hearing in accordance with
the aforesaid AAA rules. Notwithstanding the foregoing, any dispute regarding
any intellectual property rights, or the confidentiality obligations contained
in Article XI hereof shall not be subject to arbitration as set forth herein,
except to the extent that such dispute relates to Acusphere's compliance with
its obligations under the Intellectual Property Strategy.

     Section 19.05. WAIVER.

     Except as specifically provided for herein, the waiver from time to time by
either of the parties of any of their rights or their failure to exercise any
remedy shall not operate or be construed as a continuing waiver of same or of
any other of such Party's rights or remedies provided in this Agreement.

                                       57
<Page>

     Section 19.06. SEVERABILITY.

     In case any provision of this Agreement shall be invalid, illegal or
unenforceable, the validity, legality and enforceability of the remaining
provisions shall not in any way be affected or impaired thereby. Any provision
of this Agreement held invalid or unenforceable in part or degree will remain in
full force and effect to the extent not held invalid or unenforceable, and any
invalid or unenforceable term shall be replaced with a new term that reflects
the parties' intentions without being invalid or unenforceable.

     Section 19.07. NOTICES.

     All notices, requests and other communications to any party hereunder shall
be in writing and shall be deemed to have been given if delivered personally,
mailed by certified mail (return receipt requested) or sent by cable, telegram,
facsimile transmission or recognized overnight delivery service to the parties
at the following addresses or at such other addresses as, specified by the
parties by like notice:

     IF TO ACUSPHERE:    Acusphere, Inc.
                         500 Arsenal Street
                         Watertown, MA 02472
                         Attn:  Charles P. Cox, Ph.D., M.B.A.
                         Senior Vice President,
                         Corporate Development & Marketing
                         Telephone:  (617) 648-8829
                         Facsimile:  (617) 926-3605

     COPIES TO:          Testa, Hurwitz & Thibeault, LLP
                         125 High Street
                         Boston, MA 02110
                         Attn:  Larry Wittenberg, Esq.
                         Telephone:  (617) 248-7000
                         Facsimile:  (617) 248-7100

     IF TO NYCOMED:      Nycomed Danmark ApS
                         Langebjerg 1
                         DK 4000 Roskilde
                         Denmark
                         Attn: Managing Director
                         Telephone: +45 46 77 11 11
                         Facsimile: +45 46 75 66 40

                                       58
<Page>

     COPIES TO:          General Counsel, Nycomed Group
                         Nycomed Pharma AS
                         P.O. Box 205
                         1372 Asker
                         Norway

     Notice so given shall be deemed given and received (i) if by international
mail on the seventh (7th) day after posting; (ii) by cable, telegram, facsimile
transmission, telex or personal delivery on the date of actual transmission,
with evidence of transmission acceptance, or (as the case may be) personal or
other delivery; and (iii) if by international courier, on the fourth (4th)
business day following the day such notice is delivered to the international
courier service, or such earlier delivery date as may be confirmed to the sender
by such courier service.

     Section 19.08. INDEPENDENT CONTRACTORS.

     It is expressly agreed that Acusphere and Nycomed shall be independent
contractors and that the relationship between the two Parties shall not
constitute a partnership or agency of any kind. Neither Acusphere nor Nycomed
shall have the authority to make any statements, representations or commitments
of any kind, or to take any action, which shall be binding on the other Party,
without the prior written consent of the other Party.

     Section 19.09. RULES OF CONSTRUCTION.

     The Parties hereto agree that they have been represented by counsel during
the negotiation and execution of this Agreement and, therefore, waive the
application of any law, regulation, holding or rule of construction providing
that ambiguities in an agreement or other document will be construed against the
Party drafting such agreement or document. Whenever the context hereof shall so
require, the singular shall include the plural, the male gender shall include
the female gender and neuter, and vice versa.

     Section 19.10. PUBLICITY AND PUBLICATIONS.

          (a) PUBLICATIONS. Any proposed written publication of research results
     arising from this Agreement will be submitted to the other Party, at least
     thirty (30) days prior to submission for publication, and at least fourteen
     (14) days prior to oral disclosure or the submission of an abstract. During
     this thirty (30) day period for publication submissions and fourteen (14)
     day period for abstracts or oral disclosures, the reviewing Party shall
     identify information that in the reasonable judgment of such Party (a) will
     interfere with such Party's rights hereunder and/or (b) constitutes such
     Party's Confidential Information. Should the reviewing Party require
     additional time to conduct its review the submitting Party agrees to
     postpone the oral disclosure and submission of the manuscript or the
     abstract for up to an additional sixty (60) days. Each Party agrees to
     delete from any proposed manuscript, abstract or oral disclosure,
     information identified by the other Party as its Confidential Information.

          (b) PUBLICITY. Promptly after execution of this Agreement and adoption
     of the Intellectual Property Strategy by the Steering Committee, Acusphere
     shall be entitled to

                                       59
<Page>

     issue a press release substantially in the form attached hereto as Exhibit
     D-1 and Nycomed shall be entitled to issue a press release substantially in
     the form attached hereto as Exhibit D-2. Except for such press releases,
     neither Party will make any public announcement concerning the existence,
     or the terms, of this Agreement, without the prior written approval of the
     other Party with regard to the form, content and precise timing of such
     announcement, except such as may be required to be made by either Party in
     order to comply with applicable law, regulations, stock market rules, court
     order, or tax or securities filings. Such consent will not be unreasonably
     withheld or delayed by such other Party. Prior to any such public
     announcement, the Party wishing to make the announcement will (i) alert the
     other Party two weeks in advance that there will be a draft proposed
     announcement; and (ii) submit a draft of the proposed announcement to the
     other Party 5 working days in advance to enable the other Party to consider
     and comment thereon; and (iii) submit the proposed announcement to the
     other for final approval not less than 48 hours in advance. Failure to
     respond with comments in writing prior to 24 hours before the scheduled
     release shall be deemed to be approval of such release. Notwithstanding
     anything to the contrary in this Agreement, nothing in this Section 19.10
     is intended to prohibit either Party from republishing or restating
     information relating to this Agreement that has already been approved by
     the other Party for use in a prior press release or public announcement.

     Section 19.11. ENTIRE AGREEMENT; AMENDMENT.

     This Agreement (including the Exhibits attached hereto) sets forth all of
the covenants, promises, agreements, warranties, representations, conditions and
understandings between the parties hereto with respect to the subject matter
hereof and supersedes and terminates all prior agreements and understandings
between the Parties. There are no covenants, promises, agreements, warranties,
representations conditions or understandings, either oral or written, between
the parties other than as set forth herein. No subsequent alteration, amendment,
change or addition to this Agreement shall be binding upon the Parties hereto
unless reduced to writing and signed by the respective authorized officers of
the Parties.

     Section 19.12. HEADINGS.

     The captions contained in this Agreement are not a part of this Agreement,
but are merely guides or labels to assist in locating and reading the several
articles hereof.

     Section 19.13. COUNTERPARTS.

     This Agreement may be executed in two or more counterparts, each of which
shall be deemed an original, but all of which together shall constitute one and
the same instrument.

                                       60
<Page>

     IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be
executed in duplicate by their duly authorized officers as of the Effective
Date.

ACUSPHERE, INC.,                                 NYCOMED  DANMARK APS
a Delaware corporation                           a Danish corporation


By: /s/ Sheri C. Oberg                         By:    /s/ Hakan Bjorklund
   -----------------------------------------          -------------------------
Name:  Sherri C. Oberg                         Name:  Hakan Bjorklund
Title: President and Chief Executive Officer   Title: Chief Executive Officer,
                                                      Nycomed Group

                                       61
<Page>

                                                                  EXECUTION COPY

                                    EXHIBIT A

                        ACUSPHERE EUROPEAN PATENT RIGHTS

<Table>
<Caption>
                                                                              FILING
APPLICATION NUMBER                       TITLE                                 DATE
     <S>                            <C>                                      <C>
     EP 97906971.5                       Microencapsulated Fluorinated            27-Feb-97
     EP 0904113                     Gases for Use as Imaging Agents
     Austria (AT)
     Belgium (BE)
     Switzerland (CH)
     Germany (DE)
     Denmark (DK)
     Spain (ES)
     Finland (FI)
     France (FR)
     United Kingdom (GB)
     Greece (GR)
     Ireland (IE)
     Italy (IT)
     Liechtenstein (LI)
     Luxembourg (LU)
     Monaco (MC)
     Netherlands (NL)
     Portugal (PT)
     Sweden (SE)

     PV2812-98                           Microencapsulated Fluorinated       27-Feb-97
     Czech Republic (CZ)            Gases for Use as Imaging Agents

     P9902897                            Microencapsulated Fluorinated       27-Feb-97
     Hungary (HU)                   Gases for Use as Imaging Agents

     Pat. #312.940                       Microencapsulated Fluorinated       27-Feb-97
     Norway (NO)                    Gases for Use as Imaging Agents

     P328690                             Microencapsulated Fluorinated       27-Feb-97
     Poland (PL)                    Gases for Use as Imaging Agents

     EP97929669.6                        Polymer-Lipid Microencapsulated     27-Feb-97
     EP 0957942                      Gases for Use as Imaging Agents
     Austria (AT)
     Belgium (BE)

                                       A-1
<Page>

     Switzerland (CH)
     Germany (DE)
     Denmark (DK)
     Spain (ES)
     Finland (FI)
     France (FR)
     United Kingdom (GB)
     Greece (GR)
     Ireland (IE)
     Italy (IT)
     Liechtenstein (LI)
     Luxembourg (LU)
     Monaco (MC)
     Netherlands (NL)
     Portugal (PT)
     Sweden (SE)

     PV 328-99                      Polymer-Lipid Microencapsulated          27-Feb-97
     Czech Republic (CZ)            Gases for Use as Imaging Agents

     P0000392                       Polymer-Lipid Microencapsulated          27-Feb-97
     Hungary (HU)                   Gases for Use as Imaging Agents

     1999.0402                      Polymer-Lipid Microencapsulated          27-Feb-97
     Norway (NO)                    Gases for Use as Imaging Agents

     P331487                        Polymer-Lipid Microencapsulated          27-Feb-04
     Poland (PL)                    Gases for Use as Imaging Agents

     EP 98932957.8                  Method for Enhancing Echogenicity        30-Jun-98
     EP 0996470                     and Decreasing the Attenuation of
                                    Microencapsulated Gases

     Austria (AT)
     Belgium (BE)
     Switzerland (CH)
     Cyprus (CY)
     Germany (DE)
     Denmark (DK)
     Spain (ES)
     Finland (FI)
     France (FR)
     United Kingdom (GB)
     Greece (GR)
     Ireland (IE)
     Italy (IT)
     Liechtenstein (LI)
     Luxembourg (LU)
     Monaco (MC)

                                       A-2
<Page>

     Netherlands (NL)
     Portugal (PT)
     Sweden (SE)

     19996512                       Method for Enhancing Echogenicity        30-Jun-98
     Norway (NO)                    and Decreasing the Attenuation of
                                    Microencapsulated Gases

     EP 00928391.2                  Spray Drying Apparatus and Methods            26-Apr-00
     EP1175257                      of Use

     Austria (AT)
     Belgium (BE)
     Switzerland (CH)
     Cyprus (CY)
     Germany (DE)
     Denmark (DK)
     Spain (ES)
     Finland (FI)
     France (FR)
     United Kingdom (GB)
     Greece (GR)
     Ireland (IE)
     Italy (IT)
     Liechtenstein (LI)
     Luxembourg (LU)
     Monaco (MC)
     Netherlands (NL)
     Portugal (PT)
     Sweden (SE)

     20015351                       Spray Drying Apparatus and Methods            26-Apr-00
     Norway (NO)                    of Use

     [CONFIDENTIAL                  [CONFIDENTIAL                                 [CONFIDENTIAL
TREATMENT                           TREATMENT                                TREATMENT
REQUESTED] /*/                      REQUESTED] /*/                           REQUESTED] /*/
</Table>

                                       A-3
<Page>

                                                                  EXECUTION COPY

                                    EXHIBIT B

                        FORM OF CERTIFICATE OF COMPLIANCE

     Issue Date:
                 ---------------------------

                            CERTIFICATE OF COMPLIANCE

FOR ______________________________________________________________________

CUSTOMER _________________________________________________________________

     LOT NUMBER___________________________________________________________

FILL DATE _______________________ EXPIRY DATE ____________________________

DOSAGE  __________________________________________________________________

QUANTITY OF RELEASABLE VIALS _____________________________________________

The batch production record for this product has been reviewed for accuracy,
completeness, and compliance with established written standard procedures and in
accordance with cGMP requirements. Any deviations/abnormal occurrences from the
aforementioned requirements have been appropriately documented, reviewed, and
approved.

Reviewed By:
            --------------------------------------------
                       Batch Record Auditor

Date:
     ------------------------------


Approved By:
            --------------------------------------------
                       Head of Quality Assurance

Date:
     ------------------------------


cc:  Customers

                                       B-1
<Page>

                                                                  EXECUTION COPY

                                    EXHIBIT C

                            U.S. DEVELOPMENT PROGRAM

     AI-700 PRECLINICAL AND CLINICAL DEVELOPMENT PLAN

     AI-700 has been developed to enable stress echo to provide information on
myocardial perfusion in addition to wall motion. Numerous preclinical studies
were conducted to support the safety of the Phase 1 clinical trials. The Phase 1
clinical trials evaluated the safety and feasibility of myocardial perfusion
imaging with AI-700. The Phase 2 clinical trials evaluated the preliminary
safety and efficacy of AI-700 enhanced ultrasound imaging. Efficacy was measured
by comparing the results obtained from myocardial perfusion assessment using
AI-700 enhanced ultrasound with those obtained using nuclear stress tests.

     The Phase III clinical trials will evaluate the detection of coronary
heart disease in patients being evaluated for ischemic heart disease. The
Phase III clinical plan provides for a two-part program consisting of a pilot
phase designed to qualify and train new investigators, and two multi-center
pivotal trials of approximately 300 patients with suspected coronary disease
per trial. The end points for the trial are sensitivity and specificity in
comparison to nuclear stress, angiography or clinical outcome. The Phase III
clinical trials will take place at clinical sites in North America and
Europe, with data from the trials intended for submission to U.S., Canadian
and European regulatory authorities.

     The following preclinical studies have been, or will be completed to
support the NDA submission:

     Preclinical Studies

  -  [CONFIDENTIAL TREATMENT REQUESTED] /*/

  -  [CONFIDENTIAL TREATMENT REQUESTED] /*/

  -  [CONFIDENTIAL TREATMENT REQUESTED] /*/

  -  [CONFIDENTIAL TREATMENT REQUESTED] /*/

  -  [CONFIDENTIAL TREATMENT REQUESTED] /*/

                                       C-1
<Page>

                                                                  EXECUTION COPY

  -  [CONFIDENTIAL TREATMENT REQUESTED] /*/

  -  [CONFIDENTIAL TREATMENT REQUESTED] /*/


AI-700 MANUFACTURING SCALE UP

AI-700 production can be divided into two, multi-step processes: microsphere
intermediate production and drug product production. Scaling and validation of
both will be required for NDA filing and commercial manufacturing. The
microsphere intermediate is made using a spray drying process in which an
aqueous solution and an organic solution are sterile filtered and homogenized to
produce an emulsion, then spray dried and collected as a sterile dry powder.

The scale for NDA filing and commercial manufacturing is anticipated to be
[CONFIDENTIAL TREATMENT REQUESTED] /*/. The processes used in the [CONFIDENTIAL
TREATMENT REQUESTED] /*/ scale will be similar to the processes used in
manufacturing the clinical trial material. User requirement specifications,
functional specifications, design specifications and design drawings will be
completed for each piece of equipment needed. The scale up to [CONFIDENTIAL
TREATMENT REQUESTED] /*/ will include the following:

  -  Design, construction and installation of emissions control system

  -  Design and build process control system to monitor both the MI and DP
     processes

  -  Design and build microsphere intermediate process equipment

  -  Design and build drug product process equipment

  -  Design and build clean-in-place and steam-in-place equipment for equipment
     cleaning and sterilization

  -  Design custom process utilities, including WFI, organic solvent
     distribution, and nitrogen gas distribution

Reproducibility and comparability to previous scales will be verified prior to
technology transfer to manufacturing.

                                       C-2
<Page>

                                                                  EXECUTION COPY

                                   EXHIBIT D-1

                      FORM OF ACUSPHERE PRESS RELEASE[el]

   ACUSPHERE ANNOUNCES $70 MILLION EUROPEAN PARTNERSHIP FOR AI-700

WATERTOWN, Mass.-(BUSINESS WIRE)-July 7, 2004-Acusphere, Inc. (NASDAQ: ACUS),
a specialty pharmaceutical company that develops drug products using its
porous microparticle technology, announced today that it has entered into a
Collaboration, License and Supply Agreement with Nycomed for the European
development and marketing rights to Acusphere's lead product candidate
AI-700. Nycomed is a pan-European pharmaceutical company with about $725
million in annual revenues. AI-700 is an ultrasound contrast agent currently
in Phase 3 clinical trials for assessing myocardial perfusion in the
diagnosis of coronary heart disease, a leading cause of death in the United
States and Europe.

As part of the Agreement, Nycomed will provide $70 million in license fees,
research and development funding, and milestone payments, including
$12 million in payments over the first two years. These near-term
payments include $4 million in upfront license fees and $8 million in
research and development funding payable in eight equal quarterly installments.
An additional $58 million in milestone payments are related to regulatory
approvals and achievement of certain sales goals. In addition, Acusphere will be
paid to manufacture the product for Nycomed and will receive royalties on
Nycomed's sales of AI-700. Nycomed will be responsible for sales,
marketing and the regulatory submissions required for marketing throughout its
sales territory, which includes the member states of the European Union, as well
as Russia/CIS and Turkey.

"As one of the few pan-European pharmaceutical companies, Nycomed is an
excellent partner to develop and market AI-700 throughout Europe,"
commented Sherri C. Oberg, President and CEO of Acusphere. ""Nycomed brings a
long, successful heritage in building close relations with health care
professionals throughout the European hospital-specialist sector. This heritage,
combined with an extensive European market presence, and a clear strategy to
build a strong cardiovascular portfolio, makes Nycomed an experienced partner
with a positive reputation among European cardiologists. Nycomed has sales
forces in 19 European countries and its strategy to focus its marketing and
sales activities almost exclusively in Europe is highly compatible with our
commercial strategy in the United States, where we currently plan to build our
own marketing and sales capability for AI-700. As a pharmaceutical
company with over $700 million in revenues, Nycomed has a sophisticated
marketing and sales capability, along with an ability to focus targeted
attention on AI-700, which has the potential to represent a sizable
proportion of Nycomed's overall sales."

Hakan Bjorklund, CEO of Nycomed commented, ""We are enthusiastic about the
potential market opportunity for AI-700 in Europe and are impressed with
the clinical results to date. AI-700 is an excellent match with our
cardiovascular product focus. With the successful in-licensing of
Angiox(TM) (bivalirudin), a thrombin-specific anticoagulant for percutaneous
coronary intervention, which is scheduled for pan-European launch later
this year, we are already in the process of developing and training a hospital
specialist sales force that will call on our customer base of cardiologists in
Europe. With AI-700, we are excited to be participating in the

                                      D-1
<Page>

commercialization of a product with such great potential to improve the
diagnosis and management of coronary heart disease. We are committed to working
closely with Acusphere and we are looking forward to supporting the MAA filing
in the first half of 2006, consistent with Acusphere's planned NDA filing date."
Ultrasound is the only frequently used imaging technique without a
commercially significant imaging agent. Acusphere has designed AI-700 to
work with ultrasound in the assessment of myocardial perfusion (blood flow in
the heart muscle), a sensitive marker of coronary heart disease. In 2002, an
estimated 9.5 million procedures in the U.S. and 1.5-2.0 million
procedures in Europe were performed to screen patients with suspected coronary
heart disease, primarily using nuclear imaging. AI-700-enhanced
ultrasound is being developed as a cost-effective and convenient
alternative to nuclear imaging.

Ferghana Partners Group (New York and London), a specialist investment bank
in the life sciences field, acted as financial and transaction advisor to
Acusphere on this Agreement with Nycomed.

CONFERENCE CALL INFORMATION

Acusphere will host a conference today, July 7, 2004, at 11:00 a.m. (EDT)
to discuss this Agreement and answer questions. The conference may be heard live
via the investor relations section of our website at www.acusphere.com or by
dialing 1-800-599-9795, using the confirmation code: 47942555. For participants
dialing in from outside the U.S. please use the number 1-617-786-2905 using the
same confirmation code, 47942555. After the conference call, a replay of the
call will be made available for thirty days via our web site and a telephone
replay will be available through July 14, 2004 by dialing 1-888-286-8010,
using the confirmation code: 20088851.

ABOUT ACUSPHERE, INC.

Acusphere is a specialty pharmaceutical company that develops new drugs and
improved formulations of existing drugs using its proprietary microparticle
technology. Acusphere's three initial product candidates are in clinical
development and are designed to address large unmet clinical needs within
cardiology, oncology and asthma. These product candidates were created using
proprietary technology that enables Acusphere to control the porosity and size
of nanoparticles and microparticles in a versatile manner that allows particles
to be customized to address the delivery needs of a variety of drugs.
Acusphere's lead product candidate, AI-700, is a cardiovascular drug in
Phase 3 clinical development in the U.S. and Europe. For more information about
Acusphere visit the Company's web site at www.acusphere.com.

ABOUT NYCOMED

Nycomed is a pharmaceutical company differentiating itself by its European
focus. The company's capabilities include product sourcing, late-stage
clinical trials, registration, pricing and reimbursement negotiation and product
life-cycle management. Dedicated sales teams target general
practitioners, pharmacists and hospital specialists, including cardiologists.
With 2,800 people, mostly in marketing & sales, Nycomed covers 19 European
markets including the Russia/CIS. Products are also exported to other countries
including Japan and the USA.

                                      D-2
<Page>

Nycomed is a privately-owned company with 2003 revenues of EUR 635.5 million.
Further information is available at: www.nycomed.com.

"Acusphere" and "AI-700" are trademarks of Acusphere, Inc.

This Release contains forward-looking statements, including statements
regarding development, regulatory filings, milestone payments and commercial
potential of AI-700. The Company's actual results may differ materially
from those anticipated in these forward-looking statements based upon a number
of factors, including anticipated operating losses, uncertainties associated
with research, development, testing and related regulatory approvals, unproven
markets, future capital needs and uncertainty of additional financing,
competition, uncertainties associated with intellectual property, complex
manufacturing, high quality requirements, dependence on third-party
manufacturers, suppliers and collaborators, lack of sales and marketing
experience, loss of key personnel, uncertainties associated with market
acceptance and adequacy of reimbursement, technological change and government
regulation, and other risks and challenges detailed in the Company's filings
with the U.S. Securities and Exchange Commission, including the Company's
Quarterly Report on Form 10-Q for the quarter ended March 31, 2004.
Readers are cautioned not to place undue reliance on any forward-looking
statements, which speak only as of the date of this Release. The Company
undertakes no obligation to publicly release the results of any revisions to
these forward-looking statements that may be made to reflect events or
circumstances that occur after the date of this Release or to reflect the
occurrence of unanticipated events.

CONTACT: Acusphere, Inc.

    John F. Thero
    Investors:
    617-925-3444
    IR@acusphere.com
    or
    Media:
    617-648-8800
<Page>

                                                                  EXECUTION COPY

                                  EXHIBIT D-2

                         FORM OF NYCOMED PRESS RELEASE

          NYCOMED ANNOUNCES USD70 MILLION EUROPEAN MARKETING AGREEMENT

Nycomed announced today, 7 July 2004, that it has entered into a collaboration,
license and supply agreement with Acusphere Inc (NASDAQ: ACUS) granting Nycomed
the rights to develop and market Acusphere's lead product candidate, AI-700, in
Europe, including the Commonwealth of Independent States (CIS) and Turkey.

AI-700 is a cardiovascular product developed by Acusphere. It is an ultrasound
contrast agent for use in the evaluation of coronary artery disease, and is
being developed as a cost effective and convenient alternative to today's
nuclear imaging standard methods.

Nycomed will be responsible for European registration, marketing and sales of
AI-700, including all post-marketing clinical development activities in Europe.
Under the agreement, Nycomed also has the right to extend the license with any
future indications of the product in the territory.

Hakan Bjorklund, Nycomed CEO, said: "AI-700 proves the value of our
pan-European in licensing strategy, and further strengthens Nycomed's growing
hospital specialist portfolio. Assuming AI-700 continues to develop according to
our expectations, we are looking forward to using our cardiovascular expertise
to make this a significant product in Europe."

Nycomed will pay Acusphere up to a total of USD70 million in license fees,
development costs, milestones upon regulatory submission and approvals, and upon
achievement of certain sales targets. Furthermore, Nycomed will pay Acusphere
royalties on sales in Europe.

Sherri C. Oberg, President and CEO of Acusphere, said: "In Nycomed we have
found an excellent partner. They can provide us with access to a significant
market for AI-700, which we expect to be a cost-effective and convenient
alternative to current nuclear imaging technology."

AI-700 is currently in Phase III clinical development and trials are being
conducted in both the US and Europe. Submission for regulatory approval of
AI-700 in the US is planned for first half of 2006, and will be followed by
submission for central European approval.

ABOUT AI-700

AI-700, is a cardiovascular product in Phase III clinical development. AI-700 is
designed to be a preferred alternative to nuclear imaging technology for the
detection of coronary artery disease-the leading cause of death in Europe and in
the United States. Ultrasound is the only frequently-used imaging technique
without a commercially significant imaging agent. Acusphere has designed AI-700
to work with ultrasound for the assessment of myocardial perfusion (blood flow
in the heart muscle), a sensitive marker of coronary artery disease. AI-700 is
being developed as a cost-effective and convenient alternative to today's
nuclear imaging standard methods.
<Page>

About Acusphere

Acusphere Inc, headquartered in Watertown, Massachusetts, USA, is a specialty
pharmaceutical company that develops new drugs and improved formulations of
existing drugs using its proprietary microparticle technology. Acusphere's three
initial product candidates are in clinical development and are designed to
address large unmet clinical needs within cardiology, oncology and asthma. These
product candidates were created using proprietary technology that enables
Acusphere to control the porosity and size of nanoparticles and microparticles
in a versatile manner that allows particles to be customized to address the
delivery needs of a variety of drugs. Further information is available on:
www.acusphere.com

About Nycomed

Nycomed is a pharmaceutical company differentiating itself by its European
focus. The company's capabilities include product sourcing, late-stage clinical
trials, registration, pricing and reimbursement negotiation and product
life-cycle management. Dedicated sales teams target general practitioners,
hospital specialists and pharmacists.

With 2,800 people, mostly in marketing & sales, Nycomed covers 19 European
markets including the Russia/CIS. Products are also exported to other countries
including Japan and the USA. Nycomed is a privately-owned company with 2003
revenue of EURO 635.5 million. Further information is available on:
www.nycomed.com

For further information:

Hakan Bjorklund, CEO  Nycomed  Phone: (+45) 46 77 11 11

Christoffer Jensen, VP Communications
Nycomed
Phone: (+45) 46 77 11 12
Mobile: (+45) 22 43 69 44