**Exhibit 31.1** **Cytocore,    Inc.** **CERTIFICATION**     I, Augusto Ocana M.D., certify that:      1.      I have reviewed this report on    Form 10-KSB/A    of Cytocore, Inc.;      2.      Based on my knowledge, this report does not contain any untrue    statement of a material fact or omit to state a material fact    necessary to make the statements made, in light of the    circumstances under which such statements were made, not    misleading with respect to the period covered by this report;      3.      Based on my knowledge, the financial statements, and other    financial information included in this report, fairly present in    all material respects the financial condition, results of    operations and cash flows of the small business issuer as of,    and for, the periods presented in this report;      4.      The small business issuer’s other certifying officer and I    are responsible for establishing and maintaining disclosure    controls and procedures (as defined in Exchange Act    Rules 13a-15(e)    and    15d-15(e))    and internal control over financial reporting (as defined in    Exchange Act    Rules 13a-15(f)    and    15d-15(f))    for the small business issuer and have:      (a)      Designed such disclosure controls and procedures, or caused such    disclosure controls and procedures to be designed under our    supervision, to ensure that material information relating to the    small business issuer, including its consolidated subsidiaries,    is made known to us by others within those entities,    particularly during the period in which this report is being    prepared;      (b)      Designed such internal control over financial reporting, or    caused such internal control over financial reporting to be    designed under our supervision, to provide reasonable assurance    regarding the reliability of financial reporting and the    preparation of financial statements for external purposes in    accordance with generally accepted accounting principles;      (c)      Evaluated the effectiveness of the small business issuer’s    disclosure controls and procedures and presented in this report    our conclusions about the effectiveness of the disclosure    controls and procedures, as of the end of the period covered by    this report based on such evaluation; and      (d)      Disclosed in this report any change in the small business    issuer’s internal control over financial reporting that    occurred during the small business issuer’s most recent    fiscal quarter (the small business issuer’s fourth quarter    in the case of an annual report) that has materially affected,    or is reasonably likely to materially affect, the small business    issuer’s internal control over financial reporting; and      5.      The small business issuer’s other certifying officer and I    have disclosed, based on our most recent evaluation of internal    control over financial reporting, to the small business    issuer’s auditors and the audit committee of the small    business issuer’s board of directors (or persons performing    the equivalent functions):      (a)      All significant deficiencies and material weaknesses in the    design or operation of internal control over financial reporting    which are reasonably likely to adversely affect the small    business issuer’s ability to record, process, summarize and    report financial information; and      (b)      Any fraud, whether or not material, that involves management or    other employees who have a significant role in the small    business issuer’s internal control over financial reporting. /s/  Augusto    Ocana    Augusto Ocana    Chief Executive Officer     Date: April 26, 2007