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                            Events
 Microhaplotypes: A Comprehensive Forensic DNA Marker Event Dates
              June 22, 2021, 1:00 pm
 – 2:00 pmEastern
Event Duration
              1 hour
Location
              Online

Register

In this presentation, the subject matter expert will discuss the current status of the research conducted in the GW-FMB lab on a new multi-function DNA marker and its potential impact to the field of forensic genetics.

Microhaplotypes (microhaps) are biomarkers less than 300 nucleotides long that display multiple allelic combinations. The main advantages of microhaps over conventional short tandem repeats (STRs) include the 1) absence of stutter, 2) same-size alleles within each locus, 3) lower mutation rate, and 4) ancestry informative alleles. These forensically relevant loci can yield a power of discrimination similar to STRs while enhancing human identification (HID), mixture deconvolution, and biogeographic ancestry prediction.

Sanger sequencing does not allow determining the *cis/trans* relationship among closely related SNPs, however massively parallel sequencing (MPS) allows determining the parental haplotypes at each locus by clonally sequencing of each DNA molecule if they are included in the same amplicon. Currently, STR panels are used for mixture deconvolution and SNP assays are used for ancestry inference. Microhaplotypes can be used for both functions allowing, for example, to infer the ancestry of a minor contributor to a mixture (DNA intelligence).
View Event Page
  
  
          Details
Event Type
              Webinar
    Event Option(s)
          Online,
                        On demand

Sponsor(s) / Host(s)

National Institute of Justice (NIJ), U.S. Department of Justice;Forensic Technology Center of Excellence
    Contact
          NIJ Forensic Technology Center of Excellence

  Link
              If you have questions about this course, contact the FTCoE

  Registration Dates
              June 8, 2021 - June 22, 2021

  Registration Status
              Open

  Eligibility
              Free and open to all.

  Credits
              Certificate of completion
    
  
Read more about
    
            DNA (Deoxyribonucleic Acid)
        Forensic sciences
        Trace DNA
        Single nucleotide polymorphism (SNP)
        Evidence analysis
        Evidence analysis and processing
        Forensic Technology Center of Excellence
  
Date Created: November 19, 2020
    
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