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                                                                   EXHIBIT 10.25

                                 PROMISSORY NOTE

PRINCIPAL $100,000.                                      DATE: DECEMBER 11, 2000

     1. PRINCIPAL AND INTEREST. Ampersand Medical Corporation, a corporation
organized and existing under the laws of the State of Delaware (the "Company"),
with offices at 414 N. Orleans St., Suite 510, Chicago, Illinois, 60610 for
value received, hereby promises to pay to the order of Azimuth Corporation (the
"Holder"), with offices at 3600 Rio Vista Avenue, Suite A, Orlando, Florida
32805, or any successor in interest in lawful money of the United States at the
address of the Holder set forth below, the principal sum of One Hundred Thousand
and 00/100 Dollars ($100,000) 180 days from issue date (the "Maturity Date"),
together with simple interest from the date hereof, computed on the basis of a
365-day year from the date of original issuance until the Maturity Date, or such
earlier payment date as described below, at the rate of 12% per annum.

     2. PREPAYMENT. The principal amount of the Note, plus any accrued interest
due thereon, may be prepaid in its entirety at any time.

     3. ADDITIONAL CONSIDERATION. The Company will issue a warrant (attached as
an exhibit) entitling the Holder to purchase 1,000,000 shares of Common Stock of
the Company at an exercise price of $1.25 per share, representing the a 15%
premium over the average of the bid and ask prices of the Company's Common Stock
as listed on the OTC:BB on December 8, 2000, the commitment date of the note.

     4. DEFAULT PENALTY PROVISIONS. If the Company fails to pay the principal
and accrued interest due thereon on the maturity date, interest shall continue
to accrue as computed above at an adjusted rate of 15% per annum from the
Maturity Date until the date the note and accrued interest is paid in full.

     5. RECLASSIFICATION, ETC. If the Company at any time shall, by subdivision,
combination or reclassification of securities or otherwise, change any of the
securities into which the attached warrant is convertible into the same or a
different number of securities of any class or classes of securities of the
Company, or exchange any such securities in a merger or acquisition for
securities or property of another Company, the Holder shall be entitled to the
same rights in such new securities or property as the Holder would have been
entitled to if immediately prior to such change the Holder had acquired shares
of Common Stock into which the warrant is convertible.

     6. USE OF PROCEEDS. The proceeds of the Note shall be used to fund a
payment of $100,000 to AccuMed International, Inc., required in accordance with
the proposed terms of a potential agreement to acquire AccuMed.

     7. GOVERNING LAW. The Note is delivered in and shall be construed in
accordance with the laws of the State of Illinois, without regard to conflicts
of laws provisions thereof.


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        IN WITNESS WHEREOF, and intending to be legally bound hereby, the
Company has caused this Note to be executed and delivered by its proper and duly
authorized officers as of the date first above written.


AMPERSAND MEDICAL CORPORATION


BY:________________________________

NAME:  LEONARD R. PRANGE
TITLE: PRESIDENT, COO/CFO