<PAGE>   1
                                                                    Exhibit 4.19


THIS WARRANT, AND THE SECURITIES ISSUABLE UPON THE EXERCISE THEREOF, HAVE NOT
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES
OR BLUE SKY LAWS OF ANY STATE OR OTHER JURISDICTION, AND NEITHER THIS WARRANT
NOR SUCH SECURITIES NOR ANY INTEREST THEREIN MAY BE OFFERED, SOLD, TRANSFERRED,
DISTRIBUTED, ASSIGNED, PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF UNLESS:
(A) THERE IS AN EFFECTIVE REGISTRATION AND/OR QUALIFICATION UNDER SUCH ACT AND
ALL SUCH APPLICABLE SECURITIES AND/OR BLUE SKY LAWS COVERING SUCH TRANSACTION,
OR (B) THE COMPANY RECEIVES AN OPINION LETTER FROM LEGAL COUNSEL TO THE HOLDER
OF THIS WARRANT OR SUCH SECURITIES (AS THE CASE MAY BE), REASONABLY SATISFACTORY
TO THE COMPANY, TO THE EFFECT THAT SUCH TRANSACTION IS EXEMPT FROM THE
APPLICABLE REGISTRATION AND/OR QUALIFICATION REQUIREMENTS OF SUCH ACT AND
APPLICABLE SECURITIES AND BLUE SKY LAWS.


                                     WARRANT
                            TO PURCHASE COMMON STOCK
                                       OF
                          AMPERSAND MEDICAL CORPORATION

Warrant No. 4 AC                1,000,000 Shares                February 7, 2001

         AMPERSAND MEDICAL CORPORATION, a Delaware corporation (the "Company"),
for value received, hereby certifies that Azimuth Corporation, or its registered
assigns, is entitled to purchase from the Company 1,000,000 duly authorized,
validly issued, fully paid and non-assessable shares of Common Stock, par value
$0.001 per share, of the Company ("Common Stock", subject to the adjustments, if
any, provided for in Section 2), at the purchase price of US$0.25 per share
(such per share price, subject to the adjustments, if any provided for in
Section 2, being hereinafter referred to as the "Exercise Price") at any time or
from time to time after the Issue Date and prior to 5:00 p.m., New York City
time, on the Expiration Date, all subject to the terms, conditions and
adjustments set forth below in this Warrant.

This Warrant (this "Warrant") is one of the Warrants to Purchase Common Stock of
the Company, similar in all respects except as to number of shares purchasable,
names of holders and dates (collectively, the "Warrants") issued by the Company,
together with its $470,000 principal amount Promissory Note dated the Original
Issue Date. Under such Promissory Note, the Company is obligated to grant
registration rights covering the Common Stock issuable hereunder within 30 days
after the Original Issue Date.

         Certain terms used and not defined above in this Warrant are defined in
Section 5.

1. EXERCISE OF WARRANT

         1.1.     MANNER OF EXERCISE. This Warrant may be exercised by the
holder hereof, in whole or in any part (including as to any fraction of a
share), during normal business hours on any Business Day until the Expiration
Date by surrender of this Warrant, with the form of Subscription Notice at the
end hereof (or a reasonable facsimile thereof) duly executed by such holder, to
the Company, accompanied by: (i) payment of the aggregate Exercise Price for the
Common Stock being purchased. Payment of the Exercise Price shall be made, at
the option of the holder hereof, either: (A) in cash or by certified or official
bank check payable to the order of the Company in the amount of the aggregate
Exercise Price (or portion thereof being paid in this manner), (B) by the
surrender of indebtedness of the Company (principal and/or interest) in an
amount equal to the aggregate Exercise Price (or portion thereof being paid in
this manner), (C) by the surrender of Common Stock, including Common Stock
obtained upon any previous exercise of this Warrant, having a Market Value (as
hereinafter defined) as of the date of exercise equal to the aggregate Exercise
Price (or portion thereof being paid in this manner), (D) by the surrender of
other warrants of the Company, having a Warrant Value (as hereinafter defined)
as of the date of exercise equal to the aggregate Exercise Price (or portion
thereof being paid in this manner), or (E) by any combination of the foregoing.
In lieu of paying the Exercise Price in the foregoing manner, the holder hereof
may, at its option, surrender to the Company all or a specified portion of this
Warrant in exchange for a number of shares of Common Stock determined by
dividing (1) the product of (i)the number of shares issuable upon exercise of
this Warrant or such specified portion (as the case may be) and (ii) the
difference between the Market Value of the Common Stock as of the date of
exercise , by (2) such Market Value. For purposes of the foregoing, "Market
Value" of the Common Stock means, as of any date, the reported closing sale
price per share of the Common Stock as of the immediately preceding Business Day
(provided there is no such reported closing sale price on such Business Day,
then the average of the last-reported bid and ask prices on such Business Day);
and "Warrant Value" means, for any
<PAGE>   2
                                                                               2


warrant as of any date, the excess (if any) of the exercise price per share
thereof over the Market Value of the Common Stock as of such date.

         1.2.     WHEN EXERCISE EFFECTIVE. Each exercise of this Warrant shall
be deemed to have been effected immediately prior to the close of business on
the Business Day on which this Warrant shall have been exercised as provided in
Section 1.1, and immediately prior to the close of business on such Business Day
the Person or Persons in whose name or names any certificate or certificates for
Common Stock shall be issuable upon such exercise as provided in Section 1.3
shall be deemed to have become the holder or holders of record thereof.

         1.3.     DELIVERY OF STOCK CERTIFICATES, ETC. As soon as practicable
after the exercise of this Warrant in whole or in any part as provided in
Section 1.1, and in any event within ten (10) days thereafter, the Company at
its expense (including the payment by it of any applicable issue taxes) will
cause to be issued in the name of and delivered to the holder hereof or, subject
to Section 3, such other Person or Persons as such holder (upon payment by such
holder of any applicable transfer taxes) may direct: (i) a certificate or
certificates for the number of shares of Common Stock to which such holder shall
be entitled upon such exercise; (ii) in case such exercise is in part only, a
new Warrant or Warrants of like tenor, calling in the aggregate on the face or
faces thereof for the number of shares of Common Stock equal to (without giving
effect to any adjustment therein from the Original Issue Date) the number of
such shares called for on the face of this Warrant minus the number of shares of
Common Stock (without giving effect to any adjustment therein from the Issue
Date) as to which this Warrant shall have been so exercised.

2. ANTI-DILUTION ADJUSTMENTS.

         (1)      Stock Splits, Stock Dividends, Combinations. If at any time
after the Original Issue Date the Company shall:

                           (A)      take a record of the holders of its Common
         Stock for the purpose of entitling them to receive a dividend payable
         in, or other distribution of, Additional Shares of Common Stock,

                           (B)      subdivide its outstanding shares of Common
         Stock into a larger number of shares of Common Stock, or

                           (C)      combine its outstanding shares of Common
         Stock into a smaller number of shares of Common Stock

then: (i) the number of shares of Common Stock issuable upon exercise of the
Warrants shall be adjusted to equal the number of shares of Common Stock which a
holder of the same number of shares of Common Stock issuable upon exercise of
the Warrants immediately prior to the occurrence of such event would own or be
entitled to receive after the occurrence of such event; and (ii) the Exercise
Price shall be adjusted to equal the product of such Exercise Price in effect
immediately prior to such adjustment and a fraction (x) the numerator of which
shall be the number of shares of Common Stock issuable upon exercise of the
Warrants immediately prior to the adjustment made pursuant to the foregoing
clause (i) and (y) the denominator shall be the number of shares of Common Stock
issuable upon exercise of the Warrants immediately after such adjustment.

         (2)      Issuance of Additional Shares of Common Stock. If at any time
after the Original Issue Date the Company shall issue or sell any Additional
Shares of Common Stock to any Person or Persons for consideration in an amount
per Additional Share of Common Stock less than the Exercise Price at the date
the Additional Shares of Common Stock are issued, then: (i) the number of shares
of Common Stock issuable upon exercise of the Warrants shall be adjusted to
equal the product of (A) the number of shares of Common Stock issuable upon
exercise of the Warrants immediately prior to the occurrence of such issuance or
sale, and (B) a fraction (x) the numerator of which shall be the number of
shares of Common Stock Outstanding immediately prior the occurrence of such
issuance or sale plus the number of Additional Shares of Common Stock to be
issued in such issuance or sale and (y) the denominator of which shall be the
number of shares of Common Stock Outstanding immediately prior to the occurrence
of such issuance or sale plus the number of shares of Common Stock which the
aggregate consideration to be paid for such Additional Shares of Common Stock
would purchase at the Exercise Price at the date such shares are issued or sold
(prior to adjustment hereunder); and (ii) the Exercise Price shall be adjusted
to equal the product of such Exercise Price in effect immediately prior to such
adjustment and a fraction (x) the numerator of which shall be the number of
shares of Common Stock issuable upon exercise of the Warrants immediately prior
to the adjustment made pursuant to the
<PAGE>   3
                                                                               3


foregoing clause (i) and (y) the denominator shall be the number of shares of
Common Stock issuable upon exercise of the Warrants immediately after such
adjustment.

         (3)      Issuance of Convertible Securities. If at any time after the
Original Issue Date the Company shall take a record of the holders of its Common
Stock for the purpose of entitling them to receive a distribution of, or shall
otherwise issue or sell, any Convertible Securities, whether or not the rights
to convert, exchange or exercise thereunder are immediately exercisable, then
the number of shares of Common Stock issuable upon exercise of the Warrants
shall be adjusted as provided in Section 2(2) on the basis that the maximum
number of Additional Shares of Common Stock issuable to effect the conversion,
exchange or exercise of all such Convertible Securities shall be deemed to have
been issued and outstanding and the Company shall have received all of the
consideration payable therefor, if any, as of the date of the actual issuance of
such Convertible Securities. After adjustment shall have been made in the number
of shares of the Common Stock issuable upon exercise of the Warrants and the
Exercise Price with respect to the distribution, issuance or sale of any
Convertible Securities ("Primary Convertible Securities") in accordance with the
foregoing, no further adjustment thereof shall be made upon the actual issuance
of (x) any Convertible Securities ("Secondary Convertible Securities") issued
upon conversion, exchange or exercise of such Primary Convertible Securities or
(y) any shares of Common Stock issued upon conversion, exchange or exercise of
such Primary Convertible Securities or Secondary Convertible Securities.

         (4)      Superseding Adjustments. If, at any time any adjustment of the
number of shares of Common Stock issuable upon exercise of the Warrants shall
have been made pursuant to subsection 2(3) as the result of any issuance of
Convertible Securities,

                           (A)      the right of conversion, exchange or
         exercise with respect to all or a portion of such Convertible
         Securities shall have expired, shall not have been exercised or shall
         be treated as having been cancelled or acquired by the Company, or

                           (B)      the consideration per share of Common Stock
         issuable pursuant to the terms of such Convertible Securities shall be
         increased or decreased, or the number of shares of Common Stock
         issuable pursuant to such terms shall be increased or decreased, solely
         by virtue of provisions therein contained for an automatic decrease in
         such consideration per share, or automatic increase in such number of
         shares, upon the occurrence of a specified date or event,

then (i) such previous adjustment shall be rescinded and annulled and the
Additional Shares of Common Stock which were deemed to have been issued by
virtue of the computation made in connection with the adjustment so rescinded
and annulled shall no longer be deemed to have been issued by virtue of such
computation, and (ii) a recomputation shall be made of the effect of such
Convertible Securities on the basis of

                           (C)      treating the number of Additional Shares of
         Common Stock or other property (if any) theretofore actually issued or
         issuable pursuant to any previous conversion, exchange or exercise (as
         the case may be) of any such Convertible Securities as having been
         issued on the date or dates of any such conversion, exchange or
         exercise and for the consideration actually received and receivable
         therefor, and

                           (D)      treating any such Convertible Securities
         which then remain outstanding as having been granted or issued
         immediately after the time of such increase or decrease (as the case
         may be)

whereupon a new adjustment of the number of shares of Common Stock issuable upon
exercise of the Warrants, and of the Exercise Price, shall be made on the basis
pursuant to the appropriate provisions of this Section 2, which new adjustment
shall supersede the previous adjustment so rescinded and annulled.

         (5)      Other Provisions Applicable to Adjustments Under this Section.
The following provisions shall be applicable to the making of adjustments
provided for in this Section 2:

                  (A)      Computation of Consideration. To the extent that any
Additional Shares of Common Stock or any Convertible Securities shall be issued
for cash consideration, the consideration received by the Company therefor shall
be the amount of the cash received by the Company therefor, or, if such
Additional Shares of Common Stock or Convertible Securities are offered by the
Company for subscription, the subscription price, or, if such Additional Shares
of Common Stock or Convertible Securities are sold to underwriters or dealers
for public offering without a subscription offering, the initial public offering
price (in any such case subtracting any amounts paid or receivable for accrued
interest
<PAGE>   4
                                                                               4


or accrued dividends and without taking into account any compensation, discounts
or expenses paid or incurred by the Company for and in the underwriting of, or
otherwise in connection with, the issuance thereof). To the extent that such
issuance shall be for a consideration other than cash, then, except as herein
otherwise expressly provided herein, the amount of such consideration shall be
deemed to be the fair value of such consideration at the time of such issuance
as determined by resolution of the Board of Directors. In case any Additional
Shares of Common Stock or any Convertible Securities shall be issued in
connection with any transaction described in Section 2(6) in which the Company
issues any securities or other property, the amount of consideration therefor
shall be deemed to be the fair value, as determined by resolution of the Board
of Directors, of such portion of the assets and business of the non-surviving
Person as such Board by resolution shall determine to be attributable to such
Additional Shares of Common Stock or Convertible Securities, as the case may be.
The consideration for any Additional Shares of Common Stock issuable pursuant to
conversion, exchange or exercise of any Convertible Securities shall be the
consideration received by the Company for issuing such Convertible Securities
plus the additional consideration (if any) payable to the Company upon the
conversion, exchange or exercise of such Convertible Securities. In case of the
issuance at any time of any Additional Shares of Common Stock or Convertible
Securities in payment or satisfaction of any dividends upon any class of stock
other than Common Stock, the Company shall be deemed to have received for such
Additional Shares of Common Stock or Convertible Securities a consideration
equal to the amount of such dividend so paid or satisfied.

                  (B)      When Adjustments to be Made. The adjustments required
by this Section 2 shall be made whenever and as often as any specified event
requiring an adjustment shall occur, except that any adjustment of the number of
shares of Common Stock into which the Notes are convertible that would otherwise
be required may be postponed (except in the case of a subdivision or combination
of shares of the Common Stock, as provided for in subsection 2.(1)) up to, but
not beyond the date of, conversion if such adjustment either by itself or with
other adjustments not previously made adds or subtracts less than 1% of the
shares of Common Stock issuable upon exercise of the Warrants immediately prior
to the making of such adjustment. Any adjustment representing a change of less
than such minimum amount (except as aforesaid) which is postponed shall be
carried forward and made as soon as such adjustment, together with other
adjustments required by this Section 2 and not previously made, would result in
a minimum adjustment or on the date of conversion. For the purpose of any
adjustment, any specified event shall be deemed to have occurred at the close of
business on the date of its occurrence.

                  (C)      Fractional Interests. In computing adjustments under
this Section 2, fractional interests in Common Stock shall be taken into account
to the nearest one-ten thousandth (1/10,000th) of a share.

                  (D)      When Adjustment Not Required. If the Company shall
take a record of the holders of its Common Stock for the purpose of entitling
them to receive a dividend or distribution or subscription or purchase rights
and shall, thereafter and before the distribution to stockholders, legally
abandon its plan to pay or deliver such dividend, distribution, subscription or
purchase rights, then thereafter no adjustment shall be required by reason of
the taking of such record and any such adjustment previously made in respect
thereof shall be rescinded and annulled.

         (6)      Reorganization, Reclassification, Merger, Consolidation or
Disposition of Assets. In the event that the Company, at any time after the
Original Issue Date, shall (i) merge or consolidate with any other Person and
the Company shall not be the resulting or surviving Person, (ii) merge or
consolidate with any other Person and the Company shall be the resulting or
surviving Person but in connection therewith the Common Stock shall be changed
into or exchanged for stock or other securities of any other Person or cash or
any other property or assets, (iii) sell, lease or otherwise transfer all or
substantially all of its property or assets to any other Person and in
connection therewith stock or other securities, cash or any other property or
assets shall be issuable or deliverable in exchange for the Common Stock, or
(iv) effect a capital reorganization or reclassification of the Common Stock
(other than in the circumstances where any of Sections 2(1), (2) or (3) apply),
then, and as a condition to the effectiveness of any such merger consolidation,
sale, lease or other transfer or capital reorganization or reclassification (as
the case may be), lawful and adequate provision shall be made so that the
holders of the Warrants shall thereafter be entitled to receive, upon exercise
thereof (in lieu of the Common Stock which such holders would have been entitled
to receive upon such exercise immediately prior to such merger, consolidation,
sale, lease or other transfer or capital reorganization or reclassification (as
the case may be)), the stock or other securities, cash or other property or
assets which such holders would have been entitled to receive had the
outstanding Warrants been exercised immediately prior to such merger,
consolidation, sale, lease or other transfer or capital reorganization or
reclassification (as the case may be), at the aggregate Exercise Price in effect
immediately prior to the such merger, consolidation, sale, lease or other
transfer or capital reorganization or reclassification (as the case may be). As
a further condition to the effectiveness of any such merger, consolidation,
sale, lease or other transfer or capital reorganization or reclassification (as
the case may be), any Person (other than the Company) who shall become obligated
to deliver any stock or other securities, cash or other property or assets in
accordance with the foregoing shall
<PAGE>   5
                                                                               5


deliver to the holders of the Warrants a written instrument by which such Person
shall expressly agree to issue and deliver any such stock or other securities,
cash or other property or assets upon exercise of the Warrants.

         (7)      Certain Limitations. Notwithstanding anything herein to the
contrary, the Company shall not enter into any transaction which, by reason of
any adjustment hereunder, would cause the Exercise Price to be less than the par
value per share of Common Stock.

         (8)      Notice of Exercise Price Adjustments. Whenever the number of
shares of Common Stock issuable upon exercise of the Warrants, or the Exercise
Price, shall be adjusted pursuant to this Section 2, the Company shall forthwith
prepare a certificate to be executed by an authorized officer of the Company
setting forth, in reasonable detail, the event requiring the adjustment and the
method by which such adjustment was calculated, specifying the number of shares
of Common Stock into which the outstanding Warrants are exercisable and (if such
adjustment was made pursuant to Section 2(6), describing the number and kind of)
any stock or other securities, cash or other property or assets for which the
outstanding Warrants are exercisable, and any change in the Exercise Price
thereof, after giving effect to such adjustment or change. The Company shall
promptly cause a signed copy of such certificate to be delivered to each holder
of Warrants at such holder's address as appears on the books of the Company. The
Company shall keep at its office copies of all such certificates and cause the
same to be available for inspection at said office during normal business hours
by any holder of Warrants or any prospective purchaser of Warrants from such
holder.

         (9)      Notice of Certain Corporate Actions. Holders of Warrants all
be entitled to the same rights to receive notices of corporate actions and other
matters pertaining to the Company as the holders of outstanding shares of Common
Stock, and the Company shall forward (or cause to be forwarded) to each holder
of Warrants, at such holder's address as appears on the books of the Company,
all notices forwarded to holders of the Common Stock generally (whether or not
legally required).

3. RESTRICTIONS ON TRANSFER

         3.1.     WARRANTS LEGEND. Except as otherwise provided in this Section
3, each Warrant shall be stamped or otherwise imprinted with a legend in
substantially the following form:

         "THIS WARRANT, AND THE SECURITIES ISSUABLE UPON THE EXERCISE THEREOF,
         HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED,
         OR THE SECURITIES OR BLUE SKY LAWS OF ANY STATE OR OTHER JURISDICTION,
         AND NEITHER THIS WARRANT NOR SUCH SECURITIES NOR ANY INTEREST THEREIN
         MAY BE OFFERED, SOLD, TRANSFERRED, DISTRIBUTED, ASSIGNED, PLEDGED,
         HYPOTHECATED OR OTHERWISE DISPOSED OF UNLESS: (A) THERE IS AN EFFECTIVE
         REGISTRATION AND/OR QUALIFICATION UNDER SUCH ACT AND ALL SUCH
         APPLICABLE SECURITIES AND/OR BLUE SKY LAWS COVERING SUCH TRANSACTION,
         OR (B) THE COMPANY RECEIVES AN OPINION LETTER FROM LEGAL COUNSEL TO THE
         HOLDER OF THIS WARRANT OR SUCH SECURITIES (AS THE CASE MAY BE),
         REASONABLY SATISFACTORY TO THE COMPANY, TO THE EFFECT THAT SUCH
         TRANSACTION IS EXEMPT FROM THE APPLICABLE REGISTRATION AND/OR
         QUALIFICATION REQUIREMENTS OF SUCH ACT AND APPLICABLE SECURITIES AND
         BLUE SKY LAWS."

         3.2.     COMMON STOCK LEGEND. Except as otherwise provided in this
Section 3, each certificate representing Common Stock shall be stamped or
otherwise imprinted with a legend in substantially the following form:

         "THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
         SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES OR BLUE SKY LAWS
         OF ANY STATE OR OTHER JURISDICTION, AND NEITHER SUCH SECURITIES NOR ANY
         INTEREST THEREIN MAY BE OFFERED, SOLD, TRANSFERRED, DISTRIBUTED,
         ASSIGNED, PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF UNLESS: (A)
         THERE IS AN EFFECTIVE REGISTRATION AND/OR QUALIFICATION UNDER SUCH ACT
         AND ALL SUCH APPLICABLE SECURITIES AND/OR BLUE SKY LAWS COVERING SUCH
         TRANSACTION, OR (B) THE CORPORATION RECEIVES AN OPINION LETTER FROM
         LEGAL COUNSEL TO THE HOLDER OF SUCH SECURITIES, REASONABLY SATISFACTORY
         TO THE CORPORATION, TO THE EFFECT THAT SUCH TRANSACTION
<PAGE>   6
                                                                               6


         IS EXEMPT FROM THE APPLICABLE REGISTRATION AND/OR QUALIFICATION
         REQUIREMENTS OF SUCH ACT AND APPLICABLE SECURITIES AND BLUE SKY LAWS."

         3.3.     RESTRICTIONS ON TRANSFER. Each offer, sale, transfer,
distribution, assignment, pledge, hypothecation or other disposal of this
Warrant, or Common Stock and any interest therein shall be subject to compliance
with the terms of the foregoing legend(s) (as applicable), and the Company may
refuse to register or otherwise recognize any transfer of this Warrant or Common
Stock not in compliance therewith.

         3.4.     TERMINATION OF COMMON STOCK RESTRICTIONS. The restrictions
imposed under this Section 3 shall terminate as to this Warrant and any shares
of Common Stock when, if and so long as such shares shall have been effectively
registered under the Securities Act and disposed of pursuant thereto. Whenever
the restrictions imposed by this Section 3 shall terminate as to this Warrant or
any shares of Common Stock Shares as hereinabove provided, the holder thereof
shall be entitled to receive from the Company, at its expense, a new Warrant or
a new certificate or certificates for such shares (as applicable) without the
legend called for hereunder.

4. TRANSFER OFFICE; OWNERSHIP; REGISTRATION OF TRANSFER, ETC.

         4.1.     TRANSFER OFFICE. The Company shall maintain a copy of the
Warrants at its corporate office

         4.2.     OWNERSHIP OF WARRANTS. The Company may deem and treat the
Person in whose name this Warrant is registered as the owner and holder thereof
for all purposes hereunder and shall not be bound by any notice to the contrary,
until presentation of this Warrant for registration of transfer as provided in
this Section 4.

         4.3.     REGISTRATION OF TRANSFER. The Company agrees to maintain at
its corporate offices books for the registration and registration of transfer of
Warrants, and (subject to the provisions of Section 3) this Warrant and all
rights hereunder are transferable, in whole or in any part, on said books at
said office upon surrender of this Warrant at said offices, together with a
written instrument of transfer of this Warrant duly executed by the holder
thereof or its duly authorized agent or attorney and funds sufficient to pay any
transfer taxes payable in respect thereof. Upon such surrender and payment, the
Company shall execute and deliver a new Warrant or Warrants in the name of the
assignee or assignees and in the denominations specified in such instrument and
this Warrant shall promptly be cancelled.

         4.4.     DIVISION OR COMBINATION OF WARRANTS. This Warrant may be
divided or combined with other Warrants upon presentation of this Warrant and of
any other Warrants with which this Warrant is to be combined at the corporate
offices of the Company, together with a written notice specifying the names and
denominations in which the new Warrant or Warrants are to be issued duly
executed by the holders hereof and thereof or their respective duly authorized
agents or attorneys. Subject to compliance with Section 4.3 as to any transfer
which may be involved in such division or combination, the Company shall execute
and deliver a new Warrant or Warrants in exchange for the Warrant or Warrants to
be divided or combined in accordance with such notice.

         4.5.     LOSS, DESTRUCTION, ETC. OF WARRANTS. Upon receipt of evidence
satisfactory to the Company of the loss, theft, mutilation or destruction of the
Warrant, and in the case of any such loss, theft or destruction upon delivery of
a written indemnity in such form and amount as shall be reasonably satisfactory
to the Company, or in the event of such mutilation upon surrender and
cancellation of the mutilated Warrant, the Company shall execute and deliver a
new Warrant of like tenor in lieu of such lost, stolen, mutilated or destroyed
Warrant. Any Warrant issued under the provisions of this Section 4.5 in lieu of
any Warrant alleged to be lost, stolen, mutilated or destroyed Warrant shall
constitute an original contractual obligation on the part of the Company.

         4.6.     EXPENSES OF DELIVERY. The Company shall bear and pay all
expenses, taxes (other than transfer taxes) and other charges incurred or
charged in connection with the preparation, issuance and delivery of the Warrant
hereunder.

5. DEFINITIONS

         For purposes of the Warrants, the following definitions, not defined
elsewhere in this Warrant, have the following meanings:

         "Additional Shares of Common Stock" means all shares of Common Stock
issued or issuable by the Company after the Original Issue Date other than
Excluded Shares.
<PAGE>   7
                                                                               7


         "Board of Directors" means the Board of Directors of the Company, or
any authorized committee thereof.

         "Business Day" means each Monday, Tuesday, Wednesday, Thursday and
Friday which is not a day on which banking institutions at the place where any
specified act pursuant to this Note is to occur are authorized or obligated by
or pursuant to law, regulation or executive order to close.

         "Convertible Securities" means evidences of indebtedness, shares of
stock, options, warrants and other purchase or subscription rights which are
convertible into, exchangeable for or exercisable for, with or without payment
of additional consideration in cash or other property, and either immediately or
upon the occurrence of a specified date or a specified event, Additional Shares
of Common Stock (which excludes, for the avoidance of doubt, Excluded Shares) or
other Convertible Securities.

"Excluded Shares" means shares of Common Stock issued or issuable: (A) to: (i)
employees, officers and/or directors of, and/or consultants to, the Company or
any of its subsidiaries in consideration of services rendered or to be rendered
to the Company or any of its subsidiaries, to otherwise compensate any such
Person and/or to retain the services of any such Person (provided that Excluded
Shares under this clause (i), including those which may have been issued (or may
be issuable upon conversion, exchange or exercise of Convertible Securities
issued) prior to the Original Issue Date may not exceed at, any time, [__]% of
the amount of Common Stock outstanding and issuable pursuant to Convertible
Securities outstanding at such time); (ii) vendors, lenders or other providers
of finance to, and/or strategic partners of, the Company or any of its
subsidiaries in consideration of favorable cash pricing, continued business
and/or other consideration or value added; and (iii) sellers and/or other
securityholders of companies, businesses or assets purchased or otherwise
acquired (including by merger, consolidation or joint venture formation) by the
Company or any of its subsidiaries; and (B) upon conversion, exchange or
exercise of Convertible Securities originally issued prior to the Original Issue
Date.

         "Expiration Date" means February 7, 2006.

         "Majority Holders" means, at any time, the holders of a majority of the
Warrants.

         "Original Issue Date" means February 7, 2001.

         "Outstanding" means, when used with reference to Common Stock at any
date as of which the number of shares thereof is to be determined, (i) all
issued and outstanding shares of Common Stock, except shares then owned or held
by or for the account of the Company or any subsidiary thereof, and shall
include all shares issuable in respect of outstanding scrip or any certificates
representing fractional interests in shares of Common Stock, and (ii) all shares
of Common Stock issuable in respect of any outstanding Convertible Securities of
the Company having a nominal conversion, exchange or exercise price.

         "Person" means any individual, firm, corporation or other entity, and
shall include any successor (by merger or otherwise) of such entity.

         "Securities Act" means the Securities Act of 1933, as amended.


         6. NO IMPAIRMENT OF RIGHTS; CERTAIN COVENANTS

         The Company will not, by amendment of its certificate of incorporation
or through any consolidation, merger, sale, lease or other transfer of property
or assets, capital reorganization or reclassification, issuance of securities,
dissolution, liquidation, winding-up or otherwise, take any action or omit to
take any action directly or indirectly avoiding or seeking to avoid the
observance or performance of the provisions of the Warrant, but shall at all
times in good faith assist in the carrying out the terms of such provisions
thereof. Without limiting the generality of the foregoing, the Company covenants
and agrees that it: (i) shall not take any action (contemplated under Section 2
or otherwise) that results in the par value of a share of Common Stock to exceed
the Exercise Price therefor; (ii) shall not take any action (contemplated under
Section 2 or otherwise) that results in the total number of shares of Common
Stock or other securities issuable
<PAGE>   8
                                                                               8


upon exercise of the Warrant exceeding the number of authorized but unissued
shares of the Company under its certificate of incorporation; and (iii) shall
otherwise take all actions as may be necessary or appropriate in order that the
Company may issue and deliver to the holders of the Warrant upon exercise
thereof at the Exercise Price, free from preemptive rights, duly authorized,
validly issued, fully paid and non-assessable shares of Common Stock which may
be issuable upon exercise thereof.

7. MISCELLANEOUS

         7.1.     NOT STOCKHOLDERS; LIMITATION OF LIABILITY. Except as expressly
provided herein, no provision of this Warrant shall be construed as conferring
upon the holder thereof the rights of a stockholder of the Company. No provision
hereof, in the absence of affirmative action by the holder hereof to purchase
Common Stock, and no mere enumeration herein of the rights, powers or privileges
of the holder hereof, shall give rise to any liability of such holder for the
purchase price of any Common Stock or otherwise as a stockholder of the Company,
whether such liability is asserted by the Company or its creditors.

         7.2.     WAIVERS AND AMENDMENTS. Any term or provision of the Warrant
may be waived, supplemented or amended in a writing executed by the Company and
executed (or consented to in writing) by the Majority Holders.

         7.3.     ILLEGALITY. If the event that any one or more of the
provisions contained in this Warrant shall be determined to be invalid,
unenforceable or illegal in any respect for any reason, the validity,
enforceability or legality of such provision in any other respect and the
remaining provisions of this Warrant shall not, at the election of the party for
whom the benefit of the provision exists, be in any way impaired.

         7.4.     NOTICES. All notices or other communications which are
required or permitted hereunder shall be in writing and sufficient if delivered
personally, sent by overnight delivery service or sent by registered or
certified mail, postage prepaid, addressed as follows: (i) if to the holder of
this Warrant, at the registered address of such holder as set forth in the
Warrant; and (ii) if to the Company, 414 N. Orleans, Suite 510, Chicago,
Illinois 60610, Attention: President; provided that exercise of this Warrant
shall be effective if effected in the manner provided in Section 1. The Company
or holder of this Warrant may by notice to the other change the address to which
notices or other communications to it are to be delivered or sent.

         7.5.     ENTIRE AGREEMENT. This Warrant contains the entire agreement
between the Company and the holder of this Warrant with respect to the subject
matter hereof and supersedes all prior arrangements or understandings with
respect thereto.

         7.6.     SPECIFIC PERFORMANCE. The holder of the Warrant shall be
entitled to the equitable remedy of specific performance by the Company in the
event of any breach by it of the terms and provisions thereof. The Company
hereby irrevocably waives, to the extent that it may do so under applicable law,
any defense based on the adequacy of a remedy at law which may be asserted as a
bar to the remedy of specific performance in any action brought against the
Company for specific performance of the Warrant.

         7.7.     DESCRIPTIVE HEADINGS; SECTION REFERENCES. The descriptive
headings of this Warrant are for convenience only and shall not control or
affect the meaning or construction of any provision of this Warrant. All Section
references set forth in this Warrant are (unless the context otherwise require)
references to sections of this Warrant.

         7.8.     GOVERNING LAW. This Warrant shall be governed by and construed
in accordance with the laws of the State of Illinois (without regard to the
choice of law principles thereof).

         IN WITNESS WHEREOF, the Company has caused this Warrant to be executed
and delivered on its behalf as of the date first above written.


                                         AMPERSAND MEDICAL CORPORATION.


                                         By:____________________________________
                                         Leonard R. Prange, President
<PAGE>   9
                                                                               9


                         AMPERSAND MEDICAL CORPORATION.

                                  Warrant #4 AC
                               Subscription Notice


         THE UNDERSIGNED, the holder of the foregoing Warrant, HEREBY ELECTS TO
EXERCISE purchase rights represented by said Warrant for, and to purchase
thereunder, ( ) shares of the Common Stock covered by said Warrant and herewith
makes payment of the full Exercise Price therefor by:

(A)  the delivery herewith of cash or a certified or official bank check payable
     to the order of the Company in the amount of $___________________;
(B)  the surrender herewith of indebtedness of the Company (principal and/or
     interest) in an amount equal of $-------------------;
(C)  the surrender herewith of Common Stock having a Market Value as of the date
     hereof of $___________________; and/or
(D)  by the surrender herewith of other warrants of the Company, having a
     Warrant Value as of the date hereof of $___________________; OR

THE UNDERSIGNED HEREBY SURRENDERS to the Company the foregoing Warrant with
respect to ____ shares of Common Stock (the "Surrendered Portion") in exchange
for a number of shares of Common Stock determined by dividing (1) the product of
(i) such Surrendered Portion and (ii) the difference between the Market Value of
the Common Stock as of the date hereof, by (2) such Market Value.

AND THE UNDERSIGNED HEREBY REQUESTS that:

(1)      the certificates for such shares (and any other securities or other
         property issuable upon such exercise): (1) be issued in the name of the
         undersigned or (if indicated in the following space), the following
         person or entity:
         _______________________________________________________________________
         and (2) be delivered to the following address:_________________________
         _______________________________________________________________________


(2)      and if such shares shall not include all of the shares (or other
         securities or other property) issuable as provided in said Warrant,
         then a new Warrant, of like tenor and date, for the balance of the
         shares issuable thereunder be executed and delivered to the undersigned
         at the following address: _____________________________________________
         ______________________________________________________________________.

         Dated:____________________




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