1

U. S. ENVIRONMENTAL PROTECTION AGENCY

Washington, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

PC Code: 090100

DP Barcode: 414839

September 23, 2013 

MEMORANDUM

SUBJECT: Tier II Drinking Water Assessment to Establish Tolerances of 

Chlorantraniliprole on Various Crops with Multiple Seasons

TO: Jennifer Urbanski, Risk Manager Reviewer

Venus Eagle, Risk Manager

Laura Nollen, Risk Manager Reviewer

Barbara Madden, Risk Manager

Kristin Rury, Health Effects Division

FROM: Christopher M. Koper, Chemist

Sujatha Sankula, Ph.D., Branch Chief 

Environmental Risk Branch I

Environmental Fate and Effects Division (7507P)

EXECUTIVE SUMMARY

A Tier II screening-level drinking water assessment was conducted to establish tolerances of 

chlorantraniliprole for various crops with multiple seasons including Brassica (Cole) leafy

vegetables, curcurbit vegetables, fruiting vegetables, leafy vegetables, legumes, root and tuber 

vegetables and strawberries. This is a follow up assessment to the drinking water assessment 

(D411577+) recently issued on 24 July 2013. 

The assessment was based on information contained in DuPontTM Coragen® (EPA Reg. No. 

352-729) insect control label and the estimated drinking water concentrations (EDWCs) were 

based on the maximum proposed application rates and management practices specified in the 

product label. The EDWCs for the human health risk assessment and modeling input parameter 

tables are presented in Table 1 and Table 2. A representative surface water modeling output file 

is attached in Appendix I. 

For surface water, the EDWCs for the scenarios modeled in this assessment did not exceed the 

previous EDWCs for use on cranberries reported in a previous drinking water assessment 
2

(D381819+) dated 01 December 2010. The previously reported acute concentration of 55.30 

μg/L, annual mean (chronic) concentration of 39.87μg/L are greater than the reported EDWCs 

from the proposed uses for all scenarios reported in Table 1. Therefore, the current EDWCs for 

surface water do not supersede the drinking water concentrations for cranberry previously 

estimated for this chemical. 

For groundwater, SCI-GROW and PRZM-GW simulations were not executed since the 

maximum rates were identical to the drinking water assessment (D411577+) recently issued on 

24 July 2013. To recall, the SCI-GROW model estimated a chlorantraniliprole concentration of 

3.42 μg/L (Table 1). In addition, PRZM-GW concentration estimates were significantly

greater than SCI-GROW estimates. To summarize, these conclusions are identical to the 

drinking water assessment (D411577+) recently issued on 24 July 2013. If additional 

refinements are necessary, please contact Chris Koper at 703.347.8065 or

koper.christopher@epa.gov.

Table 1. Chlorantraniliprole Estimated Drinking Water Concentrations (EDWCs)1for Surface Water

and Ground Water based on selected Crop Scenarios

Proposed Label Use

PRZM/EXAMS

Scenario1

(first app date)

Method2

Application Rate

(interval between 

applications)

1-in-10 

year 

acute 

(μg/L)

1-in-10 

year 

chronic 

(μg/L)

30- year 

average 

(μg/L)

Surface Water

DupontTM Coragen®insect control with RYNAXPYR

® [EPA Reg. No. 352-729]

Brassica (Cole)

Leafy Vegetables CA Cole Crop

(February 08 - foliar) A

3 app @ 0.067 lb a.i./acre

(3-day interval)

[0.2 lb a.i./A/crop]

[0.8 lb a.i./A/year]

30.47 14.31 10.76

Cucurbit Vegetables

FL Cucumber

(November 01 – foliar)

A

2 app @ 0.100 lb a.i./acre

(5-day interval)

[0.2 lb a.i./A/crop]

[0.6 lb a.i./A/year]

23.19 5.24 3.15

MI Melon

(June 11 – foliar) 17.53 8.22 6.44

MO Melon

(June 17 – foliar) 24.90 5.65 3.33

NJ Melon

(June 16 – foliar) 17.78 8.23 5.05

Fruiting Vegetables

CA Tomato

(June 17 – foliar)

A

2 app @ 0.100 lb a.i./acre

(5-day interval)

[0.2 lb a.i./A/crop]

[0.6 lb a.i./A/year]

21.05 14.30 10.89

FL Tomato

(April 7 – foliar) 26.98 4.99 3.60

PA Tomato

(June 16 – foliar) 22.02 9.32 5.84

Leafy Vegetables

CA Lettuce

(April 21 – foliar) A

2 app @ 0.100 lb a.i./acre

(3-day interval)

[0.2 lb a.i./A/crop]

[0.8 lb a.i./A/year]

30.05 15.94 12.04

Legumes

MI Beans

(July 13 – foliar) A

2 app @ 0.100 lb a.i./acre

(3-day interval)

[0.2 lb a.i./A/crop]

[0.6 lb a.i./A/year]

36.32 15.07 9.37
3

Table 1. Chlorantraniliprole Estimated Drinking Water Concentrations (EDWCs)1for Surface Water

and Ground Water based on selected Crop Scenarios

Proposed Label Use

PRZM/EXAMS

Scenario1

(first app date)

Method2

Application Rate

(interval between 

applications)

1-in-10 

year 

acute 

(μg/L)

1-in-10 

year 

chronic 

(μg/L)

30- year 

average 

(μg/L)

Root and Tuber Vegetables

Leaves of Root and Tuber 

Vegetables

FL Carrot

(January 01 – foliar)

A

3 app @ 0.067 lb a.i./acre

(3-day interval)

[0.2 lb a.i./A/crop]

[0.8 lb a.i./A/year]

32.17 6.25 4.27

ID Potato

(August 01 – foliar) 16.03 11.29 9.92

ME Potato

(September 17 – foliar) 21.40 11.96 10.02

MN Sugarbeet

(September 17 – foliar) 25.54 20.05 13.85

NC Sweet Potato

(September 01 – foliar) 34.82 11.68 8.74

Strawberry FL Strawberry

(October 27 – foliar) A

3 app @ 0.067 lb a.i./acre

(7-day interval)

[0.2 lb a.i./A/crop]

[0.4 lb a.i./A/year]

12.17 2.50 1.66

Ground Water

SCI-GROW

Brassica (Cole) Leafy Vegs

Root and Tuber Vegs -- 12 app @ 0.067 lb a.i./acre 3.42 3.42 3.42

PRZM-GW

Wisconsin Corn Scenario

Brassica (Cole) Leafy Vegs

Root and Tuber Vegs ---

11 app x 0.073 lb a.i./acre 2221 207*--

1 For surface water (PRZM/EXAM), EDWC values adjusted with a Percent Cropped Area (PCA) factor of 0.91. For ground water 

(SCI-GROW and PRZM-GW), no PCA adjustment was utilized. 

2 The maximum application rate of 0.80 lb a.i./A/year was divided by 11 instead of 12 because the shell of PRZM-GW maximum 

application number is 11.

* PRZM-GW value represents the post-breakthrough average.
4

Table 2. PRZM/EXAMS Input Parameters for Chlorantraniliprole

Input Parameter: Value: Comment: Source:

Scenario(s): Brassica (Cole) Leafy Vegetables:

CA Cole Crop

Curcurbit Vegetables:

FL Cucumber

MI, MO, NJ Melon

Fruiting Vegetables:

CA, FL, PA Tomato

Leafy Vegetables:

CA Lettuce

Legumes:

MI Beans

Leaves of /and Root and Tuber 

Vegetables:

FL Carrot

ID, ME Potato

MN Sugarbeet

NC Sweet Potato

Strawberry:

FL Strawberry

representative scenarios for each use N/A

Maximum Single 

Application Rate

lbs a.i./acre (kg a.i./ha)

Brassica (Cole) Leafy Vegs: 0.067 

(0.075) 

Curcurbit Vegetables: 0.100 (0.112) 

Fruiting Vegetables: 0.100 (0.112) 

Leafy Vegetables: 0.100 (0.112) 

Legumes: 0.100 (0.112) 

Leaves of /and Root and Tuber Vegs: 

0.067 (0.075) 

Strawberry: 0.067 (0.075) 

proposed maximum single application 

rate

proposed label
5

Table 2. PRZM/EXAMS Input Parameters for Chlorantraniliprole

Input Parameter: Value: Comment: Source:

Applications per Year Brassica (Cole) Leafy Vegs: 12

(3 apps/season x 4 seasons)

Curcurbit Vegetables: 6

(2 apps/season x 3 seasons)

Fruiting Vegetables: 6

(2 apps/season x 3 seasons)

Leafy Vegetables: 8

(2 apps/season x 4 seasons)

Legumes: 6

(2 apps/season x 3 seasons)

Leaves of /and Root and Tuber Vegs: 

12

(3 apps/season x 4 seasons)

Strawberry: 6

(3 apps/season x 3 seasons) 

label directions. Application number 

for maximum single application rate.

proposed label

Application Interval (days) Brassica (Cole) Leafy Vegs: 3

Curcurbit Vegetables: 5

Fruiting Vegetables: 5

Leafy Vegetables: 3

Legumes: 3

Leaves of /and Root & Tuber Vegs: 3

Strawberry: 7 

proposed application intervals proposed label
6

Table 2. PRZM/EXAMS Input Parameters for Chlorantraniliprole

Input Parameter: Value: Comment: Source:

Date of Initial Application

(scenario: day-month)

Brassica (Cole) Leafy Vegetables:

CA Cole Crop: 08-02

Curcurbit Vegetables:

FL Cucumber: 01-11

MI Melon: 11-06

MO Melon: 17-06

NJ Melon: 16-06

Fruiting Vegetables:

CA Tomato: 17-06

FL Tomato: 07-04

PA Tomato: 16-06

Leafy Vegetables:

CA Lettuce: 21-04

Legumes:

MI Beans: 13-07

Leaves of /and Root and Tuber 

Vegetables:

FL Carrot: 01-01

ID Potato: 01-08

ME Potato: 17-09

MN Sugarbeet: 17-09

NC Sweet Potato: 01-09

Strawberry:

FL Strawberry: 27-10

For most crops, to give a representative 

window of the growing season, the date 

of initial application was selected as 

two weeks (14 days) before crop 

maturation from crop scenario data. 

For FL Cucumber, November 01 was 

selected as the initial date of 

application in order to fit all 

applications in a given calendar year 

which is needed to run the model.

Crop Scenarios

Application Method Foliar: aerial label directions proposed label

CAM Input 2 (foliar: aerial, ground) (2) linear foliar based on crop canopy US EPA, 2005

IPSCND Input Brassica (Cole) Leafy Vegs: 2

Curcurbit Vegetables: 3

Fruiting Vegetables: 3

Leafy Vegetables: 2

Legumes: 3

Leaves of /and Root & Tuber Vegs: 3

Strawberry: 3 

...remaining pesticide on foliage is (2) 

remaining pesticide on foliage is 

completely removed after harvest (3) is 

retained as surface residue and 

continues to decay. This input only 

applies to foliar applications (CAM 2).

US EPA, 2005

Spray Drift Fraction 0.16 (aerial) -- Input parameter 

guidance (USEPA, 

2009) 

Application Efficiency 0.95 (aerial) -- Input parameter 

guidance 

(USEPA, 2009)

Molecular Mass (g/mol) 483.15 -- --

Vapor Pressure at 25°C 

(torr)

1.57 x 10-13-- DuPont 16517

Henry’s Law Constant

(atm-m

3

/mol)

9.76 x 10-14 estimated calculated from 

solubility, vapor 

pressure and 

molecular weight

Solubility in Water (mg/L) 1.023 -- MRID 46889026
7

Table 2. PRZM/EXAMS Input Parameters for Chlorantraniliprole

Input Parameter: Value: Comment: Source:

Organic Carbon Partition 

Coefficient (KOC) (L/kgOC)

330 1represents the average KOC from 5 

values

MRID 46889123

Aerobic Soil Metabolism 

Half-life (days)

627 2 , 3, 4 Calculated 90th percentile of mean. 

(mean= 509 days, SD= 253 days, t= 

1.40, n= 9)

*Several reported half-lives in MRID 

46889124

were not used because of poor fit with 

first-order degradation model

MRID 46889014

MRID 46889015

MRID 46889124

Aerobic Aquatic 

Metabolism Half-life (days)

341 2 Calculated 90th percentile of mean. 

Mean= 178 days, SD= 74.95 days, t= 

3.078, n=2

MRID 46889016

Anaerobic Aquatic 

Metabolism Half-life (days)

624 208 days single half-life

(3 × 208 days per EFED guidance)

DuPont 14568

Hydrolysis Half-lives (days) 0 (stable) pH 7 MRID 46889017

Aqueous Photolysis

Half-life (days)

32.8 5 Natural sunlight half-life MRID 46889122

N/A = Not Applicable

1

= Koc values include 152, 438, 535, 268, 255.

2 

= tinput=Mean + (t90,n-1*SD) / √N

3

= EFED recalculated first-order half-lives for both benzo- and pyrazole-labeled chlorantraniliprole. The calculated half-lives are based on aerobic soil 

 metabolism data in non-sterile soil at 250C. Half-lives used in the assessment include 578, 537, 375, 41, 247, 228, 889, 924, 396 days. 

4 = The 90th percentile of the mean half-life for chlorantraniliprole was 600 days for half-lives values presented in the OECD Chlorantraniliprole 

 Volume 3(1): Annex B, Environmental Fate and Behavior. (mean = 491 ( 886, 539, 380, 233, 323, 629, 423, 518 days); SD=203; t90, n-1 =1.417; N=8

5 

= The natural sunlight half-life value of 32.8 days was modeled because this better half-life characterizes the behavior of 

 chlorantraniliprole in the environment. MRID 46889018 calculates a half-life of 0.31 days from a xenon arc lamp experiment using

 continuous irradiation.

APPENDIX I: Representative Outputs
8

PRZM/EXAMS: Michigan Beans – Aerial Application to represent Legumes

stored as MIbeansAdw.out

Chemical: Chlorantraniliprole

PRZM environment: MIbeansSTD.txt modified Tueday, 29 May 2007 at 13:56:44

EXAMS environment: ir298.exv modified Tueday, 26 August 2008 at 06:14:07

Metfile: w14826.dvf modified Tueday, 26 August 2008 at 06:15:04

Water segment concentrations (ppb)

Year Peak 96 hr 21 Day 60 Day 90 Day Yearly

1961 24.88 24.41 22.92 20.94 19.61 6.86

1962 12.58 12.45 11.91 10.92 10.30 8.33

1963 9.06 8.93 8.44 8.20 7.79 5.89

1964 11.11 10.93 10.28 9.06 8.62 6.00

1965 19.59 19.25 18.03 17.03 15.83 9.18

1966 11.46 11.34 10.84 9.90 9.34 7.68

1967 12.76 12.59 12.10 11.18 10.79 7.23

1968 34.87 34.45 32.42 28.19 25.74 13.09

1969 17.28 17.10 16.43 15.27 14.33 10.98

1970 18.11 17.85 16.97 16.15 15.45 9.64

1971 11.95 11.80 11.28 10.33 9.86 8.43

1972 16.78 16.57 15.92 15.27 14.83 9.86

1973 18.69 18.44 17.70 16.45 15.88 9.92

1974 16.05 15.85 15.13 13.91 13.05 9.87

1975 53.72 53.00 51.41 45.96 42.11 17.51

1976 25.09 24.83 23.80 21.74 20.38 15.20

1977 14.50 14.29 13.74 12.51 11.97 9.95

1978 14.96 14.72 14.05 12.50 11.61 7.88

1979 9.37 9.27 8.86 8.05 7.66 6.25

1980 16.43 16.16 15.27 13.59 12.61 7.35

1981 23.68 23.31 22.03 19.74 18.84 10.27

1982 14.98 14.78 14.16 13.53 13.47 10.31

1983 18.21 17.91 16.88 16.35 15.58 9.80

1984 12.23 12.05 11.51 11.12 10.89 8.85

1985 40.47 39.78 37.44 33.37 30.83 13.91

1986 42.84 42.22 40.46 36.73 34.29 19.32

1987 27.26 26.83 25.62 22.89 21.49 16.71

1988 17.71 17.44 16.62 15.68 15.12 11.58

1989 22.64 22.27 20.95 18.55 17.24 11.13

1990 16.16 15.94 15.06 14.57 13.93 9.92

Sorted results

Prob. Peak 96 hr 21 Day 60 Day 90 Day Yearly

0.03 53.72 53.00 51.41 45.96 42.11 19.32

0.06 42.84 42.22 40.46 36.73 34.29 17.51

0.10 40.47 39.78 37.44 33.37 30.83 16.71

0.13 34.87 34.45 32.42 28.19 25.74 15.20

0.16 27.26 26.83 25.62 22.89 21.49 13.91

0.19 25.09 24.83 23.80 21.74 20.38 13.09

0.23 24.88 24.41 22.92 20.94 19.61 11.58

0.26 23.68 23.31 22.03 19.74 18.84 11.13

0.29 22.64 22.27 20.95 18.55 17.24 10.98

0.32 19.59 19.25 18.03 17.03 15.88 10.31

0.35 18.69 18.44 17.70 16.45 15.83 10.27

0.39 18.21 17.91 16.97 16.35 15.58 9.95

0.42 18.11 17.85 16.88 16.15 15.45 9.92

0.45 17.71 17.44 16.62 15.68 15.12 9.92

0.48 17.28 17.10 16.43 15.27 14.83 9.87

0.52 16.78 16.57 15.92 15.27 14.33 9.86

0.55 16.43 16.16 15.27 14.57 13.93 9.80

0.58 16.16 15.94 15.13 13.91 13.47 9.64

0.61 16.05 15.85 15.06 13.59 13.05 9.18

0.65 14.98 14.78 14.16 13.53 12.61 8.85

0.68 14.96 14.72 14.05 12.51 11.97 8.43

0.71 14.50 14.29 13.74 12.50 11.61 8.33

0.74 12.76 12.59 12.10 11.18 10.89 7.88

0.77 12.58 12.45 11.91 11.12 10.79 7.68

0.81 12.23 12.05 11.51 10.92 10.30 7.35

0.84 11.95 11.80 11.28 10.33 9.86 7.23

0.87 11.46 11.34 10.84 9.90 9.34 6.86

0.90 11.11 10.93 10.28 9.06 8.62 6.25

0.94 9.37 9.27 8.86 8.20 7.79 6.00

0.97 9.06 8.93 8.44 8.05 7.66 5.89

0.10 39.91 39.25 36.94 32.85 30.32 16.56 15.07

36.32 Average of yearly averages: 10.30 9.37

Inputs generated by pe5.pl - Novemeber 2006

Data used for this run:

Output File: MIbeansAdw

Metfile: w14826.dvf

PRZM scenario: MIbeansSTD.txt

EXAMS environment file: ir298.exv

Chemical Name: Chlorantraniliprole

Description Variable NameValue Units Comments

Molecular weight mwt 483.15 g/mol

Henry's Law Const. henry 9.76E-14 atm-m^3/mol

Vapor Pressure vapr 1.57E-13 torr

Solubility sol 1.023 mg/L

Kd Kd mg/L

Koc Koc 330 mg/L

Photolysis half-life kdp 32.8 days Half-life

Aerobic Aquatic Metabolism kbacw 341 days Halfife

Anaerobic Aquatic Metabolism kbacs 624 days Halfife

Aerobic Soil Metabolism asm 627 days Halfife

Hydrolysis: pH 7 0 days Half-life

Method: CAM 2 integer See PRZM manual

Incorporation Depth: DEPI cm

Application Rate: TAPP 0.112 kg/ha

Application Efficiency: APPEFF 0.95 fraction

Spray Drift DRFT 0.16 fraction of application rate applied to pond

Application Date Date 13-07 dd/mm or dd/mmm or dd-mm or dd-mmm

Interval 1 interval 3 days Set to 0 or delete line for single app.

app. rate 1 apprate 0.112 kg/ha

Interval 2 interval 14 days Set to 0 or delete line for single app.

app. rate 2 apprate 0.112 kg/ha

Interval 3 interval 3 days Set to 0 or delete line for single app.

app. rate 3 apprate 0.112 kg/ha

Interval 4 interval 14 days Set to 0 or delete line for single app.

app. rate 4 apprate 0.112 kg/ha

Interval 5 interval 3 days Set to 0 or delete line for single app.

app. rate 5 apprate 0.112 kg/ha

Record 17: FILTRA

IPSCND 3

UPTKF

Record 18: PLVKRT

PLDKRT

FEXTRC 0.5

Flag for Index Res. Run IR Reservoir

Flag for runoff calc. RUNOFF total none, monthly or total(average of entire run)