Vol. 77 Wednesday, 

No. 100 May 23, 2012 

Part V 

Environmental Protection Agency 

Sixty-Ninth Report of the TSCA Interagency Testing Committee to the 

Administrator of the Environmental Protection Agency; Receipt of Report 

and Request for Comments; Notice 

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30856 Federal Register / Vol. 77, No. 100 / Wednesday, May 23, 2012 / Notices 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPPT–2011–1020; FRL–9346–3] 

Sixty-Ninth Report of the TSCA 

Interagency Testing Committee to the 

Administrator of the Environmental 

Protection Agency; Receipt of Report 

and Request for Comments 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: The Toxic Substances Control 

Act (TSCA) Interagency Testing 

Committee (ITC) transmitted its 69th 

Report to the EPA Administrator on 

April 5, 2012. In the 69th ITC Report, 

which is included with this notice, the 

ITC is adding a category of cadmium 

compounds including any chemical that 

contains cadmium as part of that 

chemical’s structure, 6 non-phthalate 

plasticizers, 25 phosphate ester flame 

retardants, 2 other flame retardants, 9 

chemicals to which children living near 

hazardous waste sites may be exposed, 

and a category of 69 diisocyanates and 

related compounds (including 14 Action 

Plan chemicals and 55 related 

compounds) to the TSCA Priority 

Testing List. In addition, the ITC is 

removing 103 cadmium compounds and 

14 High Production Volume (HPV) 

Challenge Program orphan chemicals 

from the Priority Testing List during this 

reporting period (June to November 

2011). The ITC is adding the category of 

cadmium compounds and removing 103 

cadmium compounds to provide a more 

comprehensive approach to assessing 

cadmium compounds’ safety. 

DATES: Comments must be received on 

or before June 22, 2012. 

ADDRESSES: Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPPT–2011–1020, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the online 

instructions for submitting comments. 

• Mail: Document Control Office 

(7407M), Office of Pollution Prevention 

and Toxics (OPPT), Environmental 

Protection Agency, 1200 Pennsylvania 

Ave. NW., Washington, DC 20460–0001. 

• Hand Delivery: OPPT Document 

Control Office (DCO), EPA East Bldg., 

Rm. 6428, 1201 Constitution Ave. NW., 

Washington, DC. Attention: Docket ID 

Number EPA–HQ–OPPT–2011–1020. 

The DCO is open from 8 a.m. to 4 p.m., 

Monday through Friday, excluding legal 

holidays. The telephone number for the 

DCO is (202) 564–8930. Such deliveries 

are only accepted during the DCO’s 

normal hours of operation, and special 

arrangements should be made for 

deliveries of boxed information. 

Instructions: Direct your comments to 

docket ID number EPA–HQ–OPPT– 

2011–1020. EPA’s policy is that all 

comments received will be included in 

the docket without change and may be 

made available online at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or 

email. The regulations.gov Web site is 

an ‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an email comment directly 

to EPA without going through 

regulations.gov, your email address will 

be automatically captured and included 

as part of the comment that is placed in 

the docket and made available on the 

Internet. If you submit an electronic 

comment, EPA recommends that you 

include your name and other contact 

information in the body of your 

comment and with any disk or CD–ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. 

Docket: All documents in the docket 

are listed in the docket index available 

at http://www.regulations.gov. Although 

listed in the index, some information is 

not publicly available, e.g., CBI or other 

information whose disclosure is 

restricted by statute. Certain other 

material, such as copyrighted material, 

will be publicly available only in hard 

copy. Publicly available docket 

materials are available electronically at 

http://www.regulations.gov, or, if only 

available in hard copy, at the OPPT 

Docket. The OPPT Docket is located in 

the EPA Docket Center (EPA/DC) at Rm. 

3334, EPA West Bldg., 1301 

Constitution Ave. NW., Washington, 

DC. The EPA/DC Public Reading Room 

hours of operation are 8:30 a.m. to 4:30 

p.m., Monday through Friday, excluding 

legal holidays. The telephone number of 

the EPA/DC Public Reading Room is 

(202) 566–1744, and the telephone 

number for the OPPT Docket is (202) 

566–0280. Docket visitors are required 

to show photographic identification, 

pass through a metal detector, and sign 

the EPA visitor log. All visitor bags are 

processed through an X-ray machine 

and subject to search. Visitors will be 

provided an EPA/DC badge that must be 

visible at all times in the building and 

returned upon departure. 

FOR FURTHER INFORMATION CONTACT: For 

technical information contact: Dr. John 

D. Walker, Interagency Testing 

Committee (7401M), Office of Pollution 

Prevention and Toxics, Environmental 

Protection Agency, 1200 Pennsylvania 

Ave. NW., Washington, DC 20460–0001; 

telephone number: (202) 564–7527; fax 

number: (202) 564–7528; email address: 

walker.johnd@epa.gov. 

For general information contact: The 

TSCA–Hotline, ABVI–Goodwill, 422 

South Clinton Ave., Rochester, NY 

14620; telephone number: (202) 554– 

1404; email address: TSCAHotline@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this action apply to me? 

This notice is directed to the public 

in general. It may, however, be of 

particular interest to you if you 

manufacture (defined by statute to 

include import) and/or process TSCAcovered chemicals and you may be 

identified by the North American 

Industrial Classification System 

(NAICS) codes 325 and 32411. Because 

this notice is directed to the general 

public and other entities may also be 

interested, the Agency has not 

attempted to describe all the specific 

entities that may be interested in this 

action. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the 

technical person listed under FOR

FURTHER INFORMATION CONTACT. 

B. What should I consider as I prepare 

my comments for EPA? 

1. Submitting CBI. Do not submit this 

information to EPA through 

regulations.gov or email. Clearly mark 

the part or all of the information that 

you claim to be CBI. For CBI 

information in a disk or CD–ROM that 

you mail to EPA, mark the outside of the 

disk or CD–ROM as CBI and then 

identify electronically within the disk or 

CD–ROM the specific information that 

is claimed as CBI. In addition to one 

complete version of the comment that 

includes information claimed as CBI, a 

copy of the comment that does not 

contain the information claimed as CBI 

must be submitted for inclusion in the 

public docket. Information so marked 

will not be disclosed except in 

accordance with procedures set forth in 

40 CFR part 2. 

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2. Tips for preparing your comments. 

When submitting comments, remember 

to: 

i. Identify the document by docket ID 

number and other identifying 

information (subject heading, Federal 

Register date and page number). 

ii. Follow directions. The Agency may 

ask you to respond to specific questions 

or organize comments by referencing a 

Code of Federal Regulations (CFR) part 

or section number. 

iii. Explain why you agree or disagree; 

suggest alternatives and substitute 

language for your requested changes. 

iv. Describe any assumptions and 

provide any technical information and/ 

or data that you used. 

v. If you estimate potential costs or 

burdens, explain how you arrived at 

your estimate in sufficient detail to 

allow for it to be reproduced. 

vi. Provide specific examples to 

illustrate your concerns and suggest 

alternatives. 

vii. Explain your views as clearly as 

possible, avoiding the use of profanity 

or personal threats. 

viii. Make sure to submit your 

comments by the comment period 

deadline identified. 

II. Background 

The Toxic Substances Control Act 

(TSCA) (15 U.S.C. 2601 et seq.) 

authorizes the EPA Administrator to 

promulgate regulations under TSCA 

section 4(a) requiring testing of 

chemicals and chemical groups in order 

to develop data relevant to determining 

the risks that such chemicals and 

chemical groups may present to health 

or the environment. Section 4(e) of 

TSCA established the ITC to 

recommend chemicals and chemical 

groups to the EPA Administrator for 

priority testing consideration. Section 

4(e) of TSCA directs the ITC to revise 

the TSCA section 4(e) Priority Testing 

List at least every 6 months. 

You may access additional 

information about the ITC at http:// 

www.epa.gov/opptintr/itc. 

A. The 69th ITC Report 

The ITC is adding a category of 

cadmium compounds including any 

chemical that contains cadmium as part 

of that chemical’s structure, 6 nonphthalate plasticizers, 25 phosphate 

ester flame retardants, 2 other flame 

retardants, 9 chemicals to which 

children living near hazardous waste 

sites may be exposed, and a category of 

69 diisocyanates and related 

compounds (including 14 Action Plan 

chemicals and 55 related compounds) to 

the TSCA section 4(e) Priority Testing 

List. In addition, the ITC is removing 

103 cadmium compounds and 14 HPV 

Challenge Program orphan chemicals 

from the Priority Testing List during this 

reporting period (June to November 

2011). The ITC is adding the category of 

cadmium compounds and removing 103 

cadmium compounds to provide a more 

comprehensive approach to assessing 

cadmium compounds’ safety. 

B. Status of the Priority Testing List 

The Priority Testing List includes 2 

alkylphenols, 16 chemicals with 

insufficient dermal absorption rate data, 

and 164 HPV Challenge Program orphan 

chemicals, a category of cadmium 

compounds including any chemical that 

contains cadmium as part of that 

chemical’s structure, 6 non-phthalate 

plasticizers, 25 phosphate ester flame 

retardants, 2 other flame retardants, 9 

chemicals to which children living near 

hazardous waste sites may be exposed, 

and a category of 69 diisocyanates and 

related compounds (including 14 Action 

Plan chemicals and 55 related 

compounds). 

List of Subjects 

Environmental protection, Chemicals, 

Hazardous substances. 

Dated: May 15, 2012. 

Wendy C. Hamnett, 

Director, Office of Pollution Prevention and 

Toxics. 

Sixty-Ninth Report of the TSCA 

Interagency Testing Committee to the 

Administrator of the Environmental 

Protection Agency 

Table of Contents 

Summary 

I. Background 

II. TSCA Section 8 Reporting 

A. TSCA Section 8 Reporting Rules 

B. ITC’s Use of TSCA Section 8 and Other 

Information 

C. New Request To Add Chemicals to the 

TSCA Section 8(d) HaSDR Rule 

III. ITC’s Activities During This Reporting 

Period (June to November 2011) 

IV. Revisions to the TSCA Section 4(e) 

Priority Testing List 

A. Chemicals Added to the Priority Testing 

List 

1. Cadmium Compounds 

2. Non-Phthalate Plasticizers, Phosphate 

Ester Flame Retardants, and Other Flame 

Retardants 

3. Chemicals to which children living near 

hazardous waste sites may be exposed 

4. Diisocyanates and Related Compounds 

B. Chemicals Removed From the Priority 

Testing List 

1. Cadmium Compounds 

2. HPV Challenge Program Orphan 

Chemicals 

V. References 

VI. The TSCA Interagency Testing Committee 

Summary 

The ITC is adding a category of 

cadmium compounds including any 

chemical that contains cadmium as part 

of that chemical’s structure, 6 nonphthalate plasticizers, 25 phosphate 

ester flame retardants, 2 other flame 

retardants, 9 chemicals to which 

children living near hazardous waste 

sites may be exposed, and a category of 

69 diisocyanates and related 

compounds (including 14 Action Plan 

chemicals and 55 related compounds) to 

the Toxic Substances Control Act 

(TSCA) section 4(e) Priority Testing List. 

In addition, the ITC is also removing 

103 cadmium compounds and 14 High 

Production Volume (HPV) Challenge 

Program orphan chemicals from the 

Priority Testing List during this 

reporting period (June to November 

2011). The ITC is adding the category of 

cadmium compounds and removing 103 

cadmium compounds to provide a more 

comprehensive approach to assessing 

cadmium compounds’ safety. 

The TSCA section 4(e) Priority Testing 

List is Table 1 of this unit. 

TABLE 1—TSCA SECTION 4(E) PRIORITY TESTING LIST

[November 2011] 

ITC 

Report Date Chemical name/group Action 

31 ...... January 1993 ............ 2 Chemicals with insufficient dermal absorption rate data, methylcyclohexane and cyclopentane.Designated. 

32 ...... May 1993 .................. 10 Chemicals with insufficient dermal absorption rate data ................................................ Designated. 

35 ...... November 1994 ......... 4 Chemicals with insufficient dermal absorption rate data, cyclopentadiene, formamide, 

1,2,3-trichloropropane and m-nitrotoluene.

Designated. 

37 ...... November 1995 ......... Branched 4-nonylphenol (mixed isomers) ............................................................................ Recommended. 

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TABLE 1—TSCA SECTION 4(E) PRIORITY TESTING LIST—Continued 

[November 2011] 

ITC 

Report Date Chemical name/group Action 

41 ...... November 1997 ......... Phenol, 4-(1,1,3,3-tetramethylbutyl)- .................................................................................... Recommended. 

55 ...... December 2004 ......... 161 High Production Volume (HPV) Challenge Program orphan chemicals ....................... Recommended. 

56 ...... August 2005 .............. 3 HPV Challenge Program orphan chemicals ..................................................................... Recommended. 

68 ...... May 2011 .................. Cadmium ............................................................................................................................... Recommended. 

69 ...... November 2011 ......... Cadmium compounds ........................................................................................................... Recommended. 

69 ...... November 2011 ......... 6 Non-phthalate plasticizers ................................................................................................. Recommended. 

69 ...... November 2011 ......... 25 Phosphate ester flame retardants ................................................................................... Recommended. 

69 ...... November 2011 ......... 2 Other flame retardants ...................................................................................................... Recommended. 

69 ...... November 2011 ......... 9 Chemicals to which children living near hazardous waste sites may be exposed ........... Recommended. 

69 ...... November 2011 ......... 69 Diisocyanates and related compounds ........................................................................... Recommended. 

I. Background 

The ITC was established by TSCA 

section 4(e) ‘‘to make recommendations 

to the Administrator respecting the 

chemical substances and mixtures to 

which the Administrator should give 

priority consideration for the 

promulgation of rules for testing under 

section 4(a). * * * At least every six 

months * * *, the Committee shall 

make such revisions to the Priority 

Testing List as it determines to be 

necessary and transmit them to the 

Administrator together with the 

Committee’s reasons for the revisions’’ 

(Public Law 94–469, 90 Stat. 2003 et 

seq., 15 U.S.C. 2601 et seq.). ITC reports 

are available from regulations.gov 

(http://www.regulations.gov) after 

publication in the Federal Register. The 

ITC produces its revisions to the Priority 

Testing List with administrative and 

technical support from the ITC staff, ITC 

members, and their U.S. Government 

organizations, and contract support 

provided by the Environmental 

Protection Agency (EPA). ITC members 

and staff are listed at the end of this 

report. 

II. TSCA Section 8 Reporting 

A. TSCA Section 8 Reporting Rules 

Following receipt of the ITC’s report 

(and the revised Priority Testing List) by 

the EPA Administrator, EPA’s Office of 

Pollution Prevention and Toxics (OPPT) 

may add the chemicals from the revised 

Priority Testing List to the TSCA section 

8(a) Preliminary Assessment 

Information Reporting (PAIR) rule (40 

CFR part 712) and/or the TSCA section 

8(d) Health and Safety Data Reporting 

(HaSDR) rule (40 CFR part 716). The 

PAIR rule requires manufacturers 

(including importers) of chemicals 

added to the Priority Testing List to 

submit to EPA certain production and 

exposure information (http:// 

www.epa.gov/oppt/chemtest/pubs/ 

pairform.pdf). As provided for in the 

PAIR rule, whenever EPA announces 

the receipt of an ITC report, EPA 

amends, unless otherwise instructed by 

the ITC, the PAIR rule by adding the 

recommended (or designated) chemicals 

that have been added to the Priority 

Testing List by the ITC. 

The HaSDR rule requires certain past, 

current, and proposed manufacturers, 

importers, and (if specified by EPA) 

processors of listed chemicals to submit 

to EPA copies and lists of unpublished 

health and safety studies on the listed 

chemicals that they manufacture, 

import, or (if specified by EPA) process. 

As provided for in the HaSDR rule, 

whenever EPA announces the receipt of 

an ITC report, EPA amends, unless 

otherwise instructed by the ITC, the 

HaSDR rule by adding the 

recommended (or designated) chemicals 

that have been added to the Priority 

Testing List by the ITC. 

B. ITC’s Use of TSCA Section 8 and 

Other Information 

The ITC’s use of TSCA section 8 and 

other information is described in the 

52nd ITC Report (Ref. 1). 

C. New Request To Add Chemicals to 

the TSCA Section 8(d) HaSDR Rule 

The ITC is requesting that EPA add a 

category of cadmium compounds 

including any chemical that contains 

cadmium as part of that chemical’s 

structure, 6 non-phthalate plasticizers, 

25 phosphate ester flame retardants, 2 

other flame retardants, 9 chemicals to 

which children living near hazardous 

waste sites may be exposed, and a 

category of 69 diisocyanates and related 

compounds to the TSCA section 8(d) 

HaSDR rule. The category of cadmium 

compounds, 6 non-phthalate 

plasticizers, 25 phosphate ester flame 

retardants, 2 other flame retardants, 9 

chemicals to which children living near 

hazardous waste sites may be exposed, 

and a category of 69 diisocyanates and 

related compounds are discussed in 

section IV of this report. 

III. ITC’s Activities During This 

Reporting Period (June to November 

2011) 

During this reporting period, the ITC 

discussed the need to expand the 

definition of the cadmium compounds 

beyond the 103 cadmium compounds 

recommended in the 68th ITC Report 

(Ref. 2). As a result the ITC is 

recommending a category of cadmium 

compounds including any chemical that 

contains cadmium as part of that 

chemical’s structure and removing the 

103 cadmium compounds from the 

Priority Testing List. The ITC is adding 

the category of cadmium compounds 

and removing 103 cadmium compounds 

to provide a more comprehensive 

approach to assessing cadmium 

compounds’ safety. 

In addition, the ITC discussed the use 

of TSCA section 8(d) to obtain 

biomonitoring data. As a result of these 

discussions, the ITC is adding 6 nonphthalate plasticizers, 25 phosphate 

ester flame retardants, 2 other flame 

retardants, and 9 chemicals to which 

children living near hazardous waste 

sites may be exposed to the Priority 

Testing List and asking EPA to add these 

chemicals to the TSCA section 8(d) 

HaSDR rule to obtain biomonitoring 

data. The ITC also discussed adding a 

category of 69 diisocyanates and related 

compounds to the Priority Testing List 

and to the TSCA section 8(d) HaSDR 

rule to facilitate EPA’s ability to obtain 

existing studies. Finally, the ITC 

discussed EPA’s Notice of Proposed 

Rulemaking (NPRM) for HPV Challenge 

Program chemicals (Ref. 3). As a result 

of these discussions the ITC is removing 

14 HPV Challenge Program orphan 

chemicals from the Priority Testing List. 

IV. Revisions to the TSCA Section 4(e) 

Priority Testing List 

A. Chemicals Added to the Priority 

Testing List 

1. Cadmium compounds—i. 

Recommendation. The EPA and the 

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Federal Register / Vol. 77, No. 100 / Wednesday, May 23, 2012 / Notices 30859 

Consumer Product Safety Commission 

(CPSC) request that the ITC add the 

category cadmium compounds to the 

Priority Testing List to obtain health and 

safety studies on cadmium compounds 

that are present in any consumer 

product. The cadmium compounds 

category includes any chemical that 

contains cadmium as part of that 

chemical’s structure. 

ii. Rationale for recommendation. The 

EPA and the CPSC are concerned with 

the content of cadmium and cadmium 

compounds in certain children’s toys, 

jewelry, and other consumer products 

due to known toxicity and health 

concerns from exposure to cadmium 

and cadmium compounds. The EPA has 

expanded the cadmium compounds 

category to include any chemical that 

contains cadmium as part of that 

chemical’s structure to capture 

information on more than the 103 

cadmium compounds listed in the 68th 

ITC Report (Ref. 2). Cadmium remains 

on the Priority Testing List as 

recommended in the 68th ITC Report. 

iii. Supporting information. The 

supporting information for cadmium 

and cadmium compounds is described 

in the 68th ITC Report. However, the 

supporting information for this report is 

for cadmium and cadmium compounds, 

not cadmium or cadmium compounds. 

iv. Information needs. EPA and CPSC 

need health and safety studies for 

assessing the extent and degree of 

exposure and potential hazard 

associated with cadmium and cadmium 

compounds including: Epidemiological 

or clinical studies; occupational 

exposure, health effects, and ecological 

effects studies; and environmental fate 

studies (including relevant physical 

chemical properties). 

For example, EPA and CPSC need 

studies about the total amount of 

cadmium and cadmium compounds 

contained in a product, the solubility, 

and bioavailability of cadmium and 

cadmium compounds (including 

accessibility of cadmium and cadmium 

compounds to children and studies of 

the age and foreseeable behavior of 

children exposed to a product for 

children and/or children’s toys), the 

foreseeable duration and route of 

potential cadmium and cadmium 

compounds exposure through contact 

with products, and studies on the 

marketing, patterns of use, and lifecycle 

of cadmium-containing products. 

2. Non-phthalate plasticizers, 

phosphate ester flame retardants, and 

other flame retardants—i. 

Recommendation. The CPSC requests 

that the ITC add 6 non-phthalate 

plasticizers, 25 phosphate ester flame 

retardants, and 2 other flame retardants 

to the Priority Testing List to obtain 

biomonitoring studies on the identity 

and quantity of urinary metabolites. 

This recommendation is coordinated 

with the Agency for Toxic Substances 

and Disease Registry (ATSDR) and the 

National Institute of Environmental 

Health Sciences (NIEHS). 

ii. Rationale for recommendation. The 

CPSC is requesting that 6 non-phthalate 

plasticizers be added to the Priority 

Testing List because they need 

biomonitoring data on urinary 

metabolites. Phthalate plasticizers are 

being replaced with non-phthalate 

plasticizers, such as acetyl tri-n-butyl 

citrate (Chemical Abstract Service 

Registry Number (CAS No.) 77–90–7); 

di(2-ethylhexyl) adipate (CAS No. 103– 

23–1); di(2-ethylhexyl) terephthalate 

(CAS No. 6422–86–2); 2,2,4-trimethyl1,3-pentanediol diisobutyrate (CAS No. 

6846–50–0); 1,2- 

cyclohexanedicarboxylic acid, 1,2- 

diisononyl ester (CAS No. 16612–78–8); 

and 1,2-cyclohexanedicarboxylic acid, 

1,2-dinonyl ester, branched and linear 

ester (CAS No. 474919–59–0) (Table 2 of 

this unit). The 6 non-phthalate 

plasticizers identified in Table 2 of this 

unit are known to be used in children’s 

products, including teething rings and 

soft plastic toys and have the potential 

to migrate from these products into 

human saliva. 

In addition, the CPSC is requesting 

that 25 phosphate ester flame retardants 

and 2 other flame retardants be added 

to the Priority Testing List because they 

need biomonitoring data on urinary 

metabolites. The flame retardants 

identified in Tables 3A, 3B, and 4 of this 

unit are known to be used in 

upholstered furniture, automobile 

upholstery, and children’s products 

such as car seats, play pens, and toys. 

These flame retardants are substitutes 

for pentabromodiphenyl ether, which 

was withdrawn from the market due to 

environmental and health concerns. 

iii. Supporting information—a. Nonphthalate plasticizers. The nonphthalate plasticizer, di(2-ethylhexyl) 

adipate (CAS No. 103–23–1) was added 

to the Priority Testing List in the 28th 

ITC Report (Ref. 4). Di(2-ethylhexyl) 

adipate was recommended for chemical 

fate, ecological effects, and health 

effects testing because of extensive 

human and environmental exposures. 

Di(2-ethylhexyl) adipate was removed 

from the Priority Testing List in the 

32nd ITC Report because manufacturers 

committed to develop dossiers and 

necessary test data under the Screening 

Information Data Set (SIDS) program of 

the Organization for Economic 

Cooperation and Development (OECD) 

(Ref. 5). Di(2-ethylhexyl) terephthalate 

(CAS No. 6422–86–2) was added to the 

Priority Testing List in the 11th ITC 

Report as bis(2-ethylhexyl) terephthalate 

(Ref. 6). Di(2-ethylhexyl) terephthalate 

was recommended for chemical fate, 

ecological effects, and health effects 

testing because of extensive human and 

environmental exposures. Di(2- 

ethylhexyl) terephthalate was removed 

from the Priority Testing List in the 13th 

ITC Report (Ref. 7). Di(2-ethylhexyl) 

terephthalate was removed because EPA 

developed a Negotiated Testing 

Agreement with the chemical’s 

manufacturers to conduct the testing 

(Ref. 8). 2,2,4–Trimethyl-1,3- 

pentanediol diisobutyrate (CAS No. 

6846–50–0) has been reviewed by OECD 

and a SIDS dossier has been developed 

(http://www.inchem.org/documents/ 

sids/sids/6846500.pdf). 1,2– 

Cyclohexanedicarboxylic acid, 1,2- 

diisononyl ester (CAS No. 166412–78–8) 

is a plasticizer for ‘‘PVC and other polar 

polymers and can be used in 

applications that are particularly 

sensitive from a toxicological point of 

view’’ (http://www2.basf.us/plasticizers/ 

pdfs/Hex_DINCH_e_08_04.pdf). 1,2- 

Cyclohexanedicarboxylic acid, 1,2- 

dinonyl ester, branched and linear (CAS 

No. 474919–59–0) is a plasticizer that is 

‘‘recommended for medical products, 

toys and food packaging applications.’’ 

Dreyfus and Babich have demonstrated 

that all six of these non-phthalate 

plasticizers migrate into simulated 

saliva (Ref. 9). 

b. Phosphate ester flame retardants. 

Tributyl phosphate (CAS No. 126–73–8) 

was recommended with intent to 

designate in the 18th ITC Report (Ref. 

10). Tributyl phosphate was 

recommended for chemical fate, 

ecological effects, and health effects 

testing because of extensive human and 

environmental exposures. Tributyl 

phosphate was also added to the May 

19, 1986 PAIR and HaSDR rules (Ref. 

11). After reviewing extensive voluntary 

data submissions from manufacturers 

and reports submitted in response to the 

May 19, 1986 PAIR and HaSDR rules, 

the ITC designated tributyl phosphate 

for chemical fate, ecological effects, and 

health effects testing in the 19th ITC 

Report (Ref. 12). Tributyl phosphate was 

removed from the Priority Testing List in 

the 22nd ITC Report (Ref. 13). Tributyl 

phosphate was removed from the 

Priority Testing List because EPA 

proposed the testing designated by the 

ITC in a NPRM that was published on 

November 12, 1987 (Ref. 14). EPA 

required the testing designated by the 

ITC in a final rule published on August 

14, 1989 (Ref. 15). 

Tributyl phosphate (CAS No. 126–73– 

8), triisobutyl phosphate (CAS No. 126– 

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71–6) and tri(2-butoxyethyl) phosphate 

(CAS No. 78–51–3) were recommended 

for chemical fate testing and added to 

the Priority Testing List in the 26th ITC 

Report (Ref. 16). Tributyl phosphate was 

also recommended for ecological effects 

testing (plant toxicity testing) in the 

26th ITC Report. Tributyl phosphate, 

triisobutyl phosphate, and tri(2- 

butoxyethyl) phosphate were added to 

the September 28, 1990 PAIR and 

HaSDR rules (Ref. 17). After reviewing 

reports and studies submitted in 

response to the September 28, 1990 

PAIR and HaSDR rules, tributyl 

phosphate, triisobutyl phosphate and 

tri(2-butoxyethyl) phosphate were 

removed from the Priority Testing List in 

the 33rd ITC Report (Ref. 18). Tributyl 

phosphate was removed from the 

Priority Testing List because testing was 

being conducted in response to the 

August 14, 1989 final rule. Triisobutyl 

phosphate was removed from the 

Priority Testing List because it was not 

known to be domestically produced or 

imported in substantial quantities. Tri 

(2-butoxyethyl) phosphate was removed 

from the Priority Testing List because it 

was not a high priority for testing at that 

time. 

Triphenyl phosphate (CAS No. 115– 

86–6) was added to the Priority Testing 

List in the 2nd ITC Report as one of the 

chemicals in the aryl phosphates 

category (Ref. 19). The testing 

recommendations for the aryl 

phosphates category included 

carcinogenicity, mutagenicity, 

teratogenicity, other chronic effects, 

environmental effects, and 

epidemiology. Triphenyl phosphate was 

added to the June 22, 1982 PAIR rule 

(Ref. 20) and the September 2, 1982 

HaSDR rule (Ref. 21). Triphenyl 

phosphate was removed from the 

Priority Testing List in the 14th ITC 

Report (Ref. 22). Triphenyl phosphate 

was removed from the Priority Testing 

List because the aryl phosphates 

category was included in a December 

29, 1983 Advanced Notice of Proposed 

Rulemaking (ANPRM) (Ref. 23). 

Triphenyl phosphate was also included 

in a January 17, 1992 NPRM (Ref. 24). 

Tris(2-chloroethyl) phosphate (CAS 

No. 115–96–8) was added to the Priority 

Testing List in the 23rd ITC Report (Ref. 

25). Tris(2-chloroethyl) phosphate was 

recommended for chemical fate and 

ecological effects testing. Tris(2- 

chloroethyl) phosphate was added to 

the November 16, 1988 PAIR and 

HaSDR rules (Ref. 26). After reviewing 

reports and studies submitted in 

response to the November 16, 1988 

PAIR and HaSDR rules, tris(2- 

chloroethyl) phosphate was removed 

from the Priority Testing List in the 36th 

ITC Report (Ref. 27). Tris(2-chloroethyl) 

phosphate was removed from the 

Priority Testing List because the data or 

structure activity relationships 

considered by the ITC did not indicate 

a need for further testing at that time. 

Tris(1,3-dichloro-2-propyl) phosphate 

(CAS No. 13674–87–8), tris(2-chloro-1- 

propyl) phosphate (CAS No. 6145–73– 

9), and tris(1-chloro-2-propyl)phosphate 

(CAS No. 13674–84–5) were added to 

the Priority Testing List in the 23rd ITC 

Report (Ref. 25). The 3 phosphate ester 

flame retardants were recommended for 

chemical fate, ecological effects, and 

health effects testing because of 

extensive human and environmental 

exposures. The three phosphate ester 

flame retardants were included in the 

November 16, 1988 PAIR and HaSDR 

rules (Ref. 26). Several chemical fate, 

ecological effects and health effects 

studies were submitted to EPA under 

the HaSDR rule. The sunset date for 

submitting studies under the HaSDR 

rule was December 16, 1998. The three 

phosphate ester flame retardants were 

removed from the Priority Testing List in 

the 36th ITC Report because the data or 

structure activity relationships 

considered by the ITC did not indicate 

a need to designate the chemicals for 

further testing at that time (Ref. 27). 

Tris(1,3-dichloro-2-propyl) phosphate 

has been identified as a probable human 

carcinogen, and tris(chloropropyl) 

phosphate (mixture of isomers), see 

Table 3B, an analog to tris(1,3-dichloro2-propyl) phosphate, is being tested by 

the National Toxicology Program (NTP). 

The phosphate ester flame retardant 

bis(2-chloropropyl) (l-chloro-2- 

isopropyl) phosphate (CAS No. 76649– 

15–5) was added to the Priority Testing 

List in the 30th ITC Report (Ref. 28). 

Bis(2-chloropropyl) (l-chloro-2- 

isopropyl) phosphate is a component of 

tris(chloropropyl) phosphate (mixture of 

isomers). Bis(2-chloropropyl) (l-chloro2-isopropyl) phosphate was 

recommended for chemical fate, 

ecological effects and health effects 

testing because of potential human and 

environmental exposures and included 

in the May 14, 1993 PAIR and HaSDR 

rules (Ref. 29). A few studies were 

submitted to EPA under the HaSDR 

rule. Bis(2-chloropropyl) (l-chloro-2- 

isopropyl) phosphate was removed from 

the Priority Testing List in the 36th ITC 

Report because the data or structure 

activity relationships considered by the 

ITC did not indicate a need to designate 

the chemical for further testing at that 

time (Ref. 27). 

c. Other flame retardants. The 

Brominated Phthalates Panel of the 

American Chemistry Council submitted 

its test plan for bis(2-ethyl-1-hexyl) 

tetrabromophthalate (CAS No. 26040– 

51–7]) to the EPA’s HPV Challenge 

Program on July 23, 2004 (http:// 

www.epa.gov/hpv/pubs/summaries/ 

phthacid/c15484.pdf). Partially as a 

result of this submission, there are 

numerous data available for bis(2-ethyl1-hexyl) tetrabromophthalate (http:// 

iaspub.epa.gov/oppthpv/ 

quicksearch.display?pChem=102247). 

Toxicological data on 2-ethylhexyl2,3,4,5-tetrabromobenzoate (CAS 

No.183658–27–7) could not be located 

by California’s Office of Health Hazard 

Assessment (http://oehha.ca.gov/ 

multimedia/biomon/pdf/ 

120408flamedoc.pdf). Bis(2-ethly-1- 

hexyl) tetrabromophthalate and 2- 

ethylhexyl-2,3,4,5-tetrabromobenzoate 

are components of Firemaster®550, a 

flame-retardant substitute for 

pentabromodiphenyl ether. 

iv. Information needs. The CPSC 

needs biomonitoring data on the 

identity and quantity of urinary 

metabolites for the 6 non-phthalate 

plasticizers, 25 phosphate ester flame 

retardants and 2 other flame retardants 

listed in Tables 2, 3A, 3B, and 4 of this 

unit. Specifically, CPSC is seeking 

information that would help to estimate 

human exposure to these compounds. 

First, CPSC needs studies on the 

metabolism of these compounds in 

animals or humans, including the 

identification of metabolites present in 

human urine, blood or other fluids. For 

the citrates and phosphates, urinary 

metabolites may include diesters; for 

adipate the metabolites may include the 

monoester. Second, CPSC needs studies 

that measure the amount of metabolite 

present in human urine or other media. 

Third, CPSC needs quantitative studies 

of metabolism in animals or humans 

that would allow one to estimate total 

exposure from metabolite levels. 

TABLE 2—NON-PHTHALATE PLASTICIZERS BEING ADDED TO THE PRIORITY TESTING LIST

CAS No. Plasticizer 

77–90–7 ....................................................................................... 1,2,3–Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester; Acetyl tri-n-butyl 

citrate. 

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TABLE 2—NON-PHTHALATE PLASTICIZERS BEING ADDED TO THE PRIORITY TESTING LIST—Continued 

CAS No. Plasticizer 

103–23–1 ..................................................................................... Hexanedioic acid, 1,6-bis(2-ethylhexyl) ester; Di(2-ethylhexyl) adipate. 

6422–86–2 ................................................................................... 1,4–Benzenedicarboxylic acid, 1,4-bis(2-ethylhexyl) ester; Di(2-ethylhexyl) 

terephthalate. 

6846–50–0 ................................................................................... Propanoic acid, 2-methyl-, 1,1′-[2,2-dimethyl-1-(1-methylethyl)-1,3- propanediyl] 

ester; 2,2,4–Trimethyl-1,3-pentanediol diisobutyrate. 

166412–78–8 ............................................................................... 1,2–Cyclohexanedicarboxylic acid, 1,2-diisononyl ester. 

474919–59–0 ............................................................................... 1,2–Cyclohexanedicarboxylic acid, 1,2-dinonyl ester, branched and linear. 

TABLE 3A—PHOSPHATE ESTER FLAME RETARDANTS BEING ADDED TO THE PRIORITY TESTING LIST

CAS No. Flame retardant 

78–40–0 ....................................................................................... Phosphoric acid, triethyl ester; Triethyl phosphate. 

78–51–3 ....................................................................................... Ethanol, (2-butoxy-), 1,1′,1′′-phosphate; Tri(2-butoxyethyl) phosphate. 

115–86–6 ..................................................................................... Phosphoric acid, triphenyl ester; Triphenyl phosphate. 

115–96–8 ..................................................................................... Ethanol, 2-chloro-, phosphate (3:1); Tris-(2-chloroethyl) phosphate. 

126–71–6 ..................................................................................... Phosphoric acid, tris(2-methylpropyl) ester; Triisobutyl phosphate. 

126–73–8 ..................................................................................... Phosphoric acid tributyl ester; Tributyl phosphate. 

1241–94–7 ................................................................................... Phosphoric acid, 2-ethylhexyl diphenyl ester; 2–Ethylhexyl diphenyl phosphate. 

1330–78–5 ................................................................................... Phosphoric acid, tris(methylphenyl) ester; Tricresyl phosphate, mixed isomers. 

5945–33–5 ................................................................................... Phosphoric acid, P,P′-[(1-methylethylidene)di-4, 1-phenylene] P,P,P′P′- 

tetraphenyl ester; Tetraphenyl Bisphenol A diphosphate. 

6145–73–9 ................................................................................... 1–Propanol, 2-chloro-, 1,1′,1′′-phosphate; Tris(2-chloro-1-propyl)phosphate. 

13674–84–5 ................................................................................. 2–Propanol, 1-chloro-, 2,2′2′′-phosphate; Tris(1-chloro-2-propyl) phosphate. 

13674–87–8 ................................................................................. 2–Propanol, 1,3-dichloro-, phosphate (3:1); Tris(1,3-dichloro-2-propyl) phosphate. 

25155–23–1 ................................................................................. Phenol, dimethyl-, 1,1′,1‘‘-phosphate; Trixylyl phosphate. 

26444–49–5 ................................................................................. Phosphoric acid, methylphenyl diphenyl ester; Cresyl diphenyl phosphate. 

29761–21–5 ................................................................................. Phosphoric acid, isodecyl diphenyl ester; Isodecyl diphenyl phosphate. 

38051–10–4 ................................................................................. Phosphoric acid, P,P′-[2,2-bis(chloromethyl)-1,3-propanediyl] P,P,P′P′- 

tetrakis(2-chloroethyl) ester; 2,2–Bis(chloromethyl)-1,3-propanediyl tetrakis(2- 

chloroethyl) phosphate. 

56803–37–3 ................................................................................. Phosphoric acid, (1,1-dimethylethyl)phenyl diphenyl ester; tert-Butylphenyl diphenyl phosphate. 

65652–41–7 ................................................................................. Phosphoric acid, bis[(1,1-dimethylethyl)phenyl] phenyl ester; Bis (tertbutylphenyl) phenyl phosphate. 

68937–41–7 ................................................................................. Phenol, isopropylated, phosphate (3:1); Isopropylated triphenyl phosphate. 

68937–40–6 ................................................................................. Phenol, isobutylenated, phosphate (3:1); Isobutylated phenol phosphate. 

76025–08–6 ................................................................................. Phosphoric acid, bis(2-chloro-1-methylethyl) 2-chloropropyl ester; Bis(1-chloro2-isopropyl) (2-chloropropyl) phosphate. 

76649–15–5 ................................................................................. Phosphoric acid, 2-chloro-1-methylethyl bis(2-chloropropyl) ester; Bis(2- 

chloropropyl) (l-chloro-2-isopropyl) phosphate. 

181028–79–5 ............................................................................... Phosphoric trichloride, reaction products with bisphenol A and phenol; 

Bisphenol A diphosphate. 

220352–35–2 ............................................................................... Phenol, tert-Bu derivs., phosphates (3:1); Butylated triphenyl phosphate. 

TABLE 3B—THE PHOSPHATE ESTER FLAME RETARDANT, TRIS(CHLOROPROPYL) PHOSPHATE (MIXTURE OF ISOMERS), 

BEING ADDED TO THE PRIORITY TESTING LIST

CAS No. Tris(Chloropropyl) phosphate isomers 

6145–73–9 ................................................................................... 1–Propanol, 2-chloro-, 1,1′,1′′-phosphate. 

13674–84–5 ................................................................................. 2–Propanol, 1-chloro-, 2,2′,2′′-phosphate. 

76025–08–6 ................................................................................. Phosphoric acid, bis(2-chloro-1-methylethyl) 2-chloropropyl ester. 

76649–15–5 ................................................................................. Phosphoric acid, 2-chloro-1-methylethyl bis(2-chloropropyl) ester. 

TABLE 4—OTHER FLAME RETARDANTS BEING ADDED TO THE PRIORITY TESTING LIST

CAS No. Flame retardant 

26040–51–7 ................................................................................. 1,2–Benzenedicarboxylic acid, 3,4,5,6-tetrabromo-, 1,2-bis(2-ethylhexyl) ester; 

Bis(2-ethly-1-hexyl) tetrabromophthalate. 

183658–27–7 ............................................................................... Benzoic acid, 2,3,4,5-tetrabromo-, 2-ethylhexyl ester; 2–Ethylhexyl-2,3,4,5- 

tetrabromobenzoate. 

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3. Chemicals to which children living 

near hazardous waste sites may be 

exposed—i. Recommendation. ATSDR 

requests that the ITC add nine 

chemicals to which children living near 

hazardous waste sites may be exposed 

to the Priority Testing List to obtain 

biomonitoring studies on these 

chemicals. 

ii. Rationale for recommendation. 

ATSDR is requesting nine chemicals to 

which children living near hazardous 

waste sites may be exposed be added to 

the Priority Testing List because 

children constitute a particularly 

vulnerable population of individuals, 

who, based upon their increased time 

outdoors and playtime behaviors, have 

a potentially higher than normal 

exposure to these chemicals around 

hazardous waste sites. For the chemicals 

in Table 5 of this unit, there is 

insufficient information available 

concerning both background levels and 

possible elevated exposure levels for 

children. 

iii. Supporting information. ATSDR 

works closely with the Center for 

Disease Control and Prevention’s 

National Center for Environmental 

Health (NCEH), (http://www.cdc.gov/ 

nceh), in their biomonitoring program 

known as the National Report on 

Human Exposure to Environmental 

Chemicals (NHANES), (http:// 

www.cdc.gov/nchs/nhanes.htm/). At 

least three of the chemicals in Table 5 

of this unit have been included in past 

NHANES: 1,1-dichloroethane (CAS No. 

75–34–3); 1,1,2,2-tetrachloroethane 

(CAS No. 79–34–5); and 1,2- 

dichloroethane (CAS No. 107–06–2). In 

the NHANES 2003–2004 subsample: 

1,1-dichloroethane (CAS No.75–34–3); 

1,1,2,2-tetrachloroethane (CAS No. 79– 

34–3); and 1,2-dichloroethane (CAS No. 

107–06–2) were detectable in less than 

a few percent of the participants. In a 

non-representative sample of adults in 

NHANES III (1988–1994), blood levels 

were also non-detectable or detected in 

<10% of samples. ATSDR needs to 

know if children living near hazardous 

waste sites have elevated blood levels of 

the chemicals in Table 5 of this unit. 

1,1-Dichloroethane was added to the 

Priority Testing List in the 32nd ITC 

Report because it was recommended for 

dermal absorption rate testing (Ref. 5). 

1,1-Dichloroethane was also added to 

the Priority Testing List in the 55th ITC 

Report because it was a HPV chemical 

that was not sponsored for testing (Ref. 

30). 1,1-Dichloroethane was removed 

from the Priority Testing List in the 56th 

ITC Report because it was no longer a 

HPV chemical (Ref. 31). 1,1- 

Dichloroethane’s toxicity includes 

effects on the heart, such as irregular 

heartbeats, which prompted 

discontinuing its use as a surgical 

anesthetic. It is also known to cause 

kidney disease after long-term high 

exposure and has delayed growth in 

offspring of experimental animals 

exposed to high concentrations during 

pregnancy. 

1,1,2,2-Tetrachloroethane has been 

observed to cause liver damage in 

experimental animals exposed to lower 

doses for long periods. 

Benzidine (CAS No. 92–87–5), 

determined by the Department of Health 

and Human Services (HHS), World 

Health Organization (WHO) and EPA to 

be a carcinogen, can increase the risk of 

urinary bladder cancer in long term 

occupational exposures. 

1,2-Dibromomethane (CAS No. 106– 

93–4) has been found to cause 

reproductive effects in some male 

workers including sperm damage. 

Experimental animal studies found birth 

defects in the young of animals exposed 

while in utero. 

Acrolein (CAS No. 107–02–8) was 

added to the Priority Testing List in the 

27th ITC Report as 1 of 89 aldehydes 

(Ref. 32). Acrolein was recommended 

for ecological effects testing because 

there were insufficient data to 

reasonably determine or predict the 

ecological effects of aldehydes that were 

submitted to the EPA as new chemicals. 

Acrolein was removed from the Priority 

Testing List in the 45th ITC Report (Ref. 

33). Acrolein was removed because it 

was added to the OECD HPV Chemical 

Program (http://webnet.oecd.org/Hpv/ 

UI/SIDS_Details.aspx?id=6E4A94A8- 

0068-4088-8CF7-C193F61012D0). 

Acrolein is a component of tobacco 

smoke and animal studies have found 

that inhaling it causes irritation to the 

nasal cavity and damage to the lining of 

lungs. Oral exposure through drinking 

water can cause stomach irritations, 

ulcers, and bleeding. 

1,2-Dichloroethane (a.k.a. ethylene 

dichloride) was added to the Priority 

Testing List in the 35th ITC Report 

because it was recommended for dermal 

absorption rate testing (Ref. 34). 1,2- 

Dichloroethane was removed from the 

Priority Testing List in the 45th ITC 

Report (Ref. 33). 1,2-Dichloroethane was 

removed from the Priority Testing List 

because EPA published a June 9, 1999 

NPRM for dermal absorption rate testing 

(Ref. 35). 1,2-Dichloroethane has been 

found to cause nervous system 

disorders, liver, and kidney disease and 

lung effects in humans ingesting or 

inhaling large amounts. It has also been 

found to cause kidney disease in 

experimental animals that ingested low 

doses. 

Phenol (CAS No. 108–95–2) was 

added to the Priority Testing List in the 

27th ITC Report because of its very high 

production volume, potential for 

release, and presence in commercial and 

consumer products (Ref. 32). Phenol 

was removed from the Priority Testing 

List because EPA proposed the testing 

designated by the ITC in a test rule that 

was published on November 22, 1993 

(Ref. 36). Phenol, which is used as an 

antiseptic at low doses, can cause lung 

irritation, headaches and burnings eyes 

if inhaled at high doses. Repeated 

exposures can induce muscle tremors 

and loss of coordination, and high 

exposures in air for several weeks can 

cause paralysis, severe injury to the 

heart, liver, kidneys, and lungs. 

Cresols (CAS No. 1319–77–3) were 

added to the Priority Testing List in the 

1st ITC Report because their wide use as 

industrial solvents caused concerns for 

substantial occupational exposures (Ref. 

37). Cresols were removed from the 

Priority Testing List in the 13th ITC 

Report (Ref. 7). Cresols were removed 

from the Priority Testing List because 

EPA proposed the testing designated by 

the ITC in a test rule that was published 

on July 11, 1983 (Ref. 38). Cresols were 

again added to the Priority Testing List 

in the 61st ITC Report to obtain dermal 

sensitization data (Ref. 39). Cresols were 

removed from the Priority Testing List in 

the 62nd ITC Report because the Cresols 

Panel of the American Chemistry 

Council submitted studies that met the 

ITC’s data needs (Ref. 40). Cresols at 

high levels for even short exposures can 

cause irritation of the eyes, nose, and 

throat. Skin contact with high levels can 

burn the skin and can damage the 

kidneys, liver, blood, lungs, and brain. 

Experimental animal studies found 

lesions in the nose and thyroid gland 

via food exposure. 

Exposure to large amounts of 

aluminum (CAS No. 7429–90–5) dust 

can cause lung problems and decreased 

performance in some tests that measure 

functions of the nervous system. Also, 

some people with kidney disease can 

store a lot of aluminum in their bodies 

and sometimes develop bone or brain 

diseases which may be caused by the 

excess aluminum. 

iv. Information needs. For the 

chemicals listed in Table 5 of this unit, 

ATSDR needs blood levels in children 

not living near hazardous waste sites 

and in children living near hazardous 

waste sites. ATSDR needs these data to 

determine if the children living near 

hazardous waste sites have elevated 

levels of these chemicals and may be 

more susceptible to their toxic effects. 

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TABLE 5—CHEMICALS TO WHICH CHILDREN LIVING NEAR HAZARDOUS WASTE SITES MAY BE EXPOSED

CAS No. Chemical 

75–34–3 .................................................................................................................... Ethane, 1,1-dichloro-; 1,1-Dichloroethane. 

79–34–5 .................................................................................................................... Ethane, 1,1,2,2-tetrachloro-; 1,1,2,2-Tetrachloroethane. 

92–87–5 .................................................................................................................... [1,1′-Biphenyl]-4,4′diamine; Benzidine. 

106–93–4 .................................................................................................................. Ethane, 1,2-dibromo-; 1,2-Dibromoethane. 

107–02–8 .................................................................................................................. 2-Propenal; Acrolein. 

107–06–2 .................................................................................................................. Ethane, 1,2-dichloro-; 1,2-Dichloroethane. 

108–95–2 .................................................................................................................. Phenol. 

1319–77–3 ................................................................................................................ Phenol, methyl-; Cresol. 

7429–90–5 ................................................................................................................ Aluminum. 

4. Diisocyanates and related 

compounds—i. Recommendation. The 

EPA requests that the ITC add the 

category of 69 diisocyanates and related 

compounds to the Priority Testing List 

to obtain use, fate, and exposure studies 

on uncured (unreacted) diisocyanates 

and their related compounds that are 

used in the manufacture of, and present 

in, products. 

ii. Rationale for recommendation. 

EPA is concerned about diisocyanates 

and related compounds in the 

manufacture and use of products that 

may result in exposures to consumers, 

children, and the general population. 

Diisocyanates are well known dermal 

and inhalation sensitizers in the 

workplace and have been documented 

to cause asthma, lung damage, and in 

severe cases, fatal reactions. EPA is 

especially concerned about the potential 

health effects that may result from 

exposures to the consumer or selfemployed worker while using products 

containing uncured diisocyanates (e.g., 

spray applied foam insulation (rigid 

foam), sealants, adhesives, paints, floor 

finishes, and coatings) and incidental 

exposures to the children and the 

general population while such products 

are used in or around buildings 

including homes or schools (for 

example on floors and athletic tracks) 

before the product has fully reacted and 

cured. 

In April 2011, EPA published Action 

Plans for toluene diisocyanate (TDI) and 

5 related compounds (http:// 

www.epa.gov/oppt/existingchemicals/ 

pubs/actionplans/tdi.pdf) and 

methylene diphenyl diisocyanate (MDI) 

and 7 related compounds (http:// 

www.epa.gov/oppt/existingchemicals/ 

pubs/actionplans/mdi.pdf). These 

Action Plans outline EPA’s screeninglevel review of available hazard and 

exposure information on uncured 

(unreacted) MDI, TDI, and 12 additional 

related compounds. However, after 

further review, EPA recognizes that 

aspects of an exposure scenario to 

consumers are generally applicable to 

many diisocyanate compounds. 

Therefore, in addition to the 14 

diisocyanates and related compounds 

listed in the Action Plans, EPA 

identified 29 aromatic and 26 aliphatic 

diisocyanate compounds, such as 

hexamethylene diisocyanate (HDI). 

These 29 aromatic and 26 aliphatic 

diisocyanate compounds are used in 

sealants, coatings, spray foams, 

elastomers or adhesives and may be 

substituted in such products for the 14 

diisocyanates and related compounds 

listed in the Action Plans. The ITC is 

adding the 14 diisocyanates and related 

compounds listed in the Action Plans 

and the 29 aromatic and 26 aliphatic 

diisocyanate compounds to the Priority 

Testing List to provide a more 

comprehensive approach to assessing 

hazard and exposure information for 

diisocyanates and related compounds. 

The 14 diisocyanates and related 

compounds listed in the Action Plans 

and the 29 aromatic and 26 aliphatic 

diisocyanate compounds are identified 

in Table 6 of this unit. 

ITC is recommending that the 69 

diisocyanates and related compounds be 

added to the TSCA section 8(d) HaSDR 

rule to facilitate EPA’s ability to obtain 

existing studies. Studies obtained on 

these chemicals may provide updated 

information from prior requests and 

assist EPA in taking appropriate 

action(s) to protect consumers, 

commercial workers, and other affected 

citizens from exposure to uncured 

diisocyanate-containing products during 

their use. In addition, any updated 

information may assist EPA in taking 

appropriate action(s) to protect 

bystanders and building occupants, 

including children from inadvertent 

exposure to diisocyanates and related 

compounds that might be released 

during and after application of 

diisocyanate-containing products. 

The ITC recommended priority 

consideration of isocyanates as part of 

the 26th ITC Report (Ref. 16). EPA 

subsequently issued a TSCA section 

8(d) HaSDR rule for these chemicals on 

September 28, 1990 (Ref. 17). Given the 

time elapsed since that reporting rule 

was issued, the changes in the industry, 

and the increased use of diisocyanatecontaining products, EPA believes 

issuing another rule that would require 

reporting of unpublished health and 

safety studies that were not previously 

submitted is appropriate. 

iii. Supporting information—a. 

Health. Most of the data on human 

health hazards resulting from 

diisocyanate exposures are based on 

occupational populations. These data 

indicate that exposure to diisocyanates 

can cause contact dermatitis, skin and 

respiratory tract irritation, immune 

sensitization, and asthma (Ref. 41). It is 

well documented that isocyanate 

exposure is an attributable cause of 

work-related asthma, and prevalence in 

the exposed workforce is estimated at 1– 

20% (Refs. 42 and 43). 

Occupational skin exposures in 

workers exposed to MDI are of concern 

because isocyanate sensitization and/or 

asthma has occurred in cases where the 

potential for skin exposure is 

substantial, but measured airborne MDI 

monomer levels are below occupational 

exposure levels (OELs) or below the 

limits of detection with the methods 

used, or where similar MDI levels 

would be expected but MDI air 

monitoring data are not available (Refs. 

44–48). 

The minimum exposure to 

isocyanates that can elicit sensitization 

responses or asthma is not known. In 

addition, immune response and 

subsequent disease in humans can be 

quite variable (Ref. 49). Fatalities linked 

to occupational diisocyanate exposures 

in sensitized persons have been 

reported (Refs. 50 and 51). 

Cross-sensitization has been observed 

between MDI, TDI, HDI, and 

dicyclohexylmethane diisocyanate 

(HMDI) in mice, and between MDI, TDI, 

and HDI in humans (Ref. 52). 

Animal data indicate that MDI may be 

carcinogenic; however, a consistent 

association has not been reported in 

epidemiologic studies (Refs. 53 and 54). 

Animal data indicate that TDI may be 

carcinogenic (Ref. 55). HDI was negative 

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for carcinogenicity in a 2-year bioassay 

in rats (Ref. 56). 

b. Exposure. In contrast to the large 

amount of exposure data available for 

professional workers who work with 

diisocyanates, EPA is hoping to obtain 

additional exposure data characterizing 

the use and exposure scenarios of 

consumer and commercial products 

containing uncured diisocyanates. In 

addition, comparing concentrations to 

which the consumer and general 

population is or can be exposed with 

existing workplace exposure limits to 

determine overexposure is not 

appropriate because the OSHA 

permissible exposure limits (PELs) are 

not intended to protect consumers and 

the general population (Ref. 49). 

Until polyurethane products fully 

cure, there may be the potential for 

inhalation and dermal exposure. These 

exposures may result from direct use of 

products or from bystander exposure. 

The use of spray polyurethane foam 

insulation (rigid foam) products has 

resulted in personal and area air 

samples of MDI above the OSHA PEL 

(Refs. 57–60). Potential bystander 

exposures to TDI products have been 

found in the literature, including 

emissions of TDI from concrete patio 

sealants (Refs. 61 and 62). Levels of 

moisture curing polyurethanes, 

including TDI were found in air hallway 

samples of an apartment building when 

the moisture curing polyurethanes were 

being used (Ref. 63). There were 

emissions during emergency response of 

an overturned truck carrying TDI (Ref. 

64), and para-occupational exposure for 

secretaries and janitors who worked in 

the vicinity of but not directly with TDI 

(Ref. 65). 

Unbound aliphatic isocyanates used 

in coatings may remain on the surface 

of curing coating products, like paint, 

for up to several weeks (Ref. 47). In 

addition, there is potential for 

significant exposures to aliphatic 

isocyanates for direct users and 

bystanders in the auto refinishing and 

auto repair industry (Ref. 66). 

Children exposed to the same 

airborne concentrations of MDI as adults 

may receive a larger dose because 

children take more breaths per minute 

and have a higher relative tidal volume. 

An accidental acute exposure of 

children to high levels of MDI in a 

polyurethane sealant used on a school 

athletic track was associated with 

asthma-like symptoms, including among 

children with no prior history of 

respiratory dysfunction (Ref. 67). 

Children with asthma are an especially 

vulnerable population for exposure; 

they are more susceptible to 

inflammatory narrowing of the airways, 

which results in a proportionally greater 

obstruction of their smaller respiratory 

system (Refs. 68 and 69). 

Additional data characterizing the 

concentration of diisocyanates and 

related compounds in the air during and 

after use of products that may result in 

dermal, eye, or inhalation exposures to 

uncured diisocyanates will be helpful to 

the Agency. It would be helpful to 

receive additional information on the 

extent factors such as application 

techniques, product composition, 

ambient conditions, and method of 

measurement that influence the 

availability of uncured diisocyanates. 

EPA is also aware that there is 

uncertainty about the curing time of 

various products under different 

situations and that additional data could 

help address certain concerns, such as 

re-entry time, which are important for 

improving communication to prevent 

exposure. 

c. Ecotoxicity. Although there is a 

moderate acute ecotoxicity profile for 

MDI and TDI, the hazards associated 

with exposures to these chemicals have 

centered on human health effects not 

ecological effects. Experimental 

ecotoxicological data for MDI and TDI 

and their degradation products indicate 

moderate to low toxicity to aquatic 

organisms (Refs. 57 and 70–73). Other 

toxicity data suggest low likelihood of 

effects to terrestrial biota such as plants 

and earthworms (Refs. 74 and 75). 

iv. Information needs. Information is 

needed on diisocyanates and related 

compounds used to formulate a broad 

class of polyurethane products (e.g., 

sealants, adhesives, etc.) that are 

intended to further react upon end-use. 

Information is also needed on the 

percent of diisocyanates remaining, if 

any, in the final products, and/or 

studies that assess exposure to uncured 

(unreacted) diisocyanates. Studies are 

needed that provide information on the 

inhalation, dermal, and eye exposure 

potential and/or exposure levels for 

various populations; e.g., workers, 

consumers, bystanders, and building 

occupants, including children (through 

characterizing concentrations of 

diisocyanates in indoor air, outdoor air, 

blood, or urine) during and after use of 

products containing uncured 

diisocyanates. Studies are also needed 

on induction of sensitization, asthma 

development, other lung or health 

effects (irritation to the mucous 

membranes of the eyes and 

gastrointestinal and respiratory tracts, 

chest tightness, cough, nasal congestion, 

death), biomarkers of recent and longterm exposure to diisocyanates, and the 

contributory nature of skin exposure to 

the development of diisocyanate 

asthma. 

Also needed are dermal exposure 

assessments in terms of dermal 

exposure potential and extent of 

exposure to diisocyanates during 

diisocyanate-containing product use in 

occupational as well as nonoccupational (e.g., consumer use) 

settings. Although some techniques and 

methods have been developed to 

measure human skin exposure to 

diisocyanates, these techniques and 

methods have several limitations. 

Consequently studies that provide 

improved qualitative and quantitative 

methods for detecting and quantifying 

skin exposures to diisocyanates and any 

associated data on measured exposures 

are required. Studies investigating 

associations between dermal exposure 

to diisocyanates and individual 

differences in metabolism with 

biomarkers of exposure would also 

provide useful information for exposure 

assessment. Additionally, studies are 

needed that characterize uncured 

diisocyanate levels within products over 

time. Background conditions and 

information on frequency and duration 

(use patterns) to diisocyanates are also 

needed. 

EPA is also interested in obtaining 

studies that contain information on 

sampling and analytical methods under 

development for dermal exposures; 

methods for assessing exposure to total 

reactive diisocyanates; methods and 

techniques to determine potential 

dermal exposure and uptake of 

diisocyanates through the skin; 

biological monitoring methods for 

estimating exposure to diisocyanates 

through all routes of exposure; and 

efficacy of currently used personal 

protective equipment in protecting 

workers and other populations during 

product use. 

Specifically, EPA is interested in 

health and safety studies evaluating 

professional-, commercial-, and 

consumer-use products containing 

uncured diisocyanates with special 

emphasis on the following types of 

studies: 

a. Inhalation monitoring studies 

characterizing potential worker and 

consumer exposures including 

associated airborne levels of total 

reactive diisocyanates and other 

chemicals. 

b. Inhalation monitoring studies 

characterizing incidental exposures of 

bystanders and building occupants 

including associated airborne levels of 

total reactive diisocyanates and other 

chemicals. 

c. Industrial hygiene or 

epidemiological assessments of dermal 

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Federal Register / Vol. 77, No. 100 / Wednesday, May 23, 2012 / Notices 30865 

exposure to uncured diisocyanatecontaining products in occupational 

settings as well as for consumers, 

including impact of curing time on such 

exposures. 

d. Studies focusing on the 

contributory nature of skin exposure to 

the development of diisocyanate asthma 

in workers, consumers, and the general 

population, including modification of 

skin uptake of polyisocyanates by coexposure to solvents and other agents or 

by skin cuts/abrasions. 

e. Epidemiological studies that 

address induction of sensitization and 

asthma development and other observed 

health effects in exposed populations 

including exposure-response 

relationships. Also of interest is a 

discussion of factors that impact these 

processes, physiological or otherwise. 

f. Studies on advances in 

biomonitoring for sensitive biological 

markers of recent and long-term 

exposure to diisocyanates including 

studies that associate dermal exposure 

and individual differences in 

metabolism with biomarkers. 

g. Studies on recent developments 

and refinements in specific qualitative 

and quantitative techniques and 

methods for dermal exposure 

assessment including and beyond those 

currently available (e.g., pads, wipes, 

and tape stripping methods). 

h. Studies that have used emission 

testing protocols (environmental 

chambers) for sample testing that 

provide levels of uncured diisocyanates 

over time and associated curing rates in 

accordance with specific humidity and 

temperature levels and ventilation rates 

and/or building re-occupancy guidance 

after installation or use of products. 

i. Studies that provide information on 

new or under development sampling 

and analytical methods for total reactive 

diisocyanates in diverse media (vapor, 

aerosol, dust, hard surfaces) including 

studies that provide details of industry 

methods. 

j. Studies with information on testing 

protocols currently in use or in 

development for air monitoring, 

products testing, biomonitoring, or 

dermal exposure. 

k. Field studies that report on 

ventilation rates in existing and new 

buildings and their relationship to 

detected airborne levels of chemicals. 

l. Efficacy assessments of engineering 

control strategies such as dilution 

ventilation, local exhaust ventilation, 

and containment in reducing worker 

exposure as well as bystander/occupant 

exposure. 

m. Efficacy assessments of personal 

protective equipment (PPE) used for 

exposure reduction, e.g., respirators, 

chemical protective suits, gloves, 

aprons, overalls used by workers, and 

for specific types of PPE that could be 

used by consumers or bystanders. 

EPA needs the information described 

in Unit IV.A.4. iv.a. through m. on the 

diisocyanates and related compounds, 

which are listed in Table 6 of this unit. 

TABLE 6—DIISOCYANATES AND RELATED COMPOUNDS

CAS No. Chemical name Action 

91–08–7 ..................... Benzene, 1,3-diisocyanato-2-methyl- ....................................................................................................... A, B 

91–97–4 ..................... 1,1′-Biphenyl, 4,4′-diisocyanato-3,3′-dimethyl- ........................................................................................ A, C 

101–68–8 ................... Benzene, 1,1′-methylenebis[4-isocyanato- .............................................................................................. A, D 

104–49–4 ................... Benzene, 1,4-diisocyanato- ..................................................................................................................... A, C 

123–61–5 ................... Benzene, 1,3-diisocyanato- ..................................................................................................................... A, C 

139–25–3 ................... Benzene, 1,1′-methylenebis[4-isocyanato-3-methyl- ............................................................................... C 

584–84–9 ................... Benzene, 2,4-diisocyanato-1-methyl- ....................................................................................................... A, B 

822–06–0 ................... Hexane, 1,6-diisocyanato- ....................................................................................................................... A, E 

2422–91–5 ................. Benzene, 1,1′,1′′-methylidynetris[4-isocyanato- ....................................................................................... A, C 

2536–05–2 ................. Benzene, 1,1′-methylenebis[2-isocyanato- .............................................................................................. D 

2778–42–9 ................. Benzene, 1,3-bis(1-isocyanato-1-methylethyl)- ........................................................................................ C 

3173–72–6 ................. Naphthalene, 1,5-diisocyanato- ............................................................................................................... C 

3634–83–1 ................. Benzene, 1,3-bis(isocyanatomethyl)- ....................................................................................................... C 

3779–63–3 ................. 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(6-isocyanatohexyl)- ..................................................... E 

4035–89–6 ................. Imidodicarbonic diamide, N,N′,2-tris(6-isocyanatohexyl)- ........................................................................ A, E 

4098–71–9 ................. Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl- .......................................................... A, E 

4128–73–8 ................. Benzene, 1,1′-oxybis[4-isocyanato- ......................................................................................................... C 

5124–30–1 ................. Cyclohexane, 1,1′-methylenebis[4-isocyanato- ....................................................................................... A, E 

5873–54–1 ................. Benzene, 1-isocyanato-2-[(4-isocyanatophenyl)methyl]- ......................................................................... A, D 

7517–76–2 ................. Cyclohexane, 1,4-diisocyanato-, trans- .................................................................................................... E 

9016–87–9 ................. Isocyanic acid, polymethylenepolyphenylene ester ................................................................................. D 

9017–01–0 ................. Benzene, 1,3-diisocyanatomethyl-, homopolymer; TDI homopolymer .................................................... B 

9019–85–6 ................. Benzene, 1,3-diisocyanatomethyl-, trimer ................................................................................................ C 

10347–54–3 ............... Cyclohexane, 1,4-bis(isocyanatomethyl)- ................................................................................................ E 

13622–90–7 ............... Cyclohexane, 1,1′-methylenebis[4-isocyanato-, (trans,trans)- ................................................................. E 

15646–96–5 ............... Hexane, 1,6-diisocyanato-2,4,4-trimethyl- ............................................................................................... A, E 

16325–38–5 ............... Benzene, 1,2,4,5-tetrachloro-3,6-bis(isocyanatomethyl)- ........................................................................ C 

16938–22–0 ............... Hexane, 1,6-diisocyanato-2,2,4-trimethyl- ............................................................................................... A, E 

17589–24–1 ............... 1,3-Diazetidine-2,4-dione, 1,3-bis[4-[(4-isocyanatophenyl)methyl]phenyl]- ............................................. D 

23370–68–5 ............... 1,3-Diazetidine-2,4-dione, 1,3-bis[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]- ............................... E 

25686–28–6 ............... Benzene, 1,1′-methylenebis[4-isocyanato-, homopolymer; MDI homopolymer ...................................... D 

25854–16–4 ............... Benzene, bis(isocyanatomethyl)- ............................................................................................................. A, C 

26447–40–5 ............... Benzene, 1,1′-methylenebis[isocyanato- ................................................................................................. A, D 

26471–62–5 ............... Benzene, 1,3-diisocyanatomethyl- ........................................................................................................... A, B 

26603–40–7 ............... 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(3-isocyanatomethylphenyl)- ........................................ A, B 

26747–90–0 ............... 1,3-Diazetidine-2,4-dione, 1,3-bis(3-isocyanatomethylphenyl)- ............................................................... A, B 

28182–81–2 ............... Hexane, 1,6-diisocyanato-, homopolymer; hexamethylene diisocyanate (HDI) homopolymer ............... E 

31107–36–5 ............... 1,3-Diazetidin-2-one, 1,3-bis[4-[(4-isocyanatophenyl)methyl]phenyl]-4-[[4-[(4-isocyanatophenyl) 

methyl]phenyl]imino]-.

D 

38661–72–2 ............... Cyclohexane, 1,3-bis(isocyanatomethyl)- ................................................................................................ E 

42170–25–2 ............... Cyclohexane, bis(isocyanatomethyl)- ...................................................................................................... E 

50639–37–7 ............... 2H-1,3,5-Oxadiazine-2,4,6(3H,5H)-trione, 3,5-bis(6-isocyanatohexyl)- ................................................... E 

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TABLE 6—DIISOCYANATES AND RELATED COMPOUNDS—Continued 

CAS No. Chemical name Action 

50830–59–6 ............... 1,3,4-Thiadiazole, 2-isocyanato-5-(trifluoromethyl)-, dimer ..................................................................... C 

51508–06–6 ............... 1,3,4-Thiadiazole, 2-(1,1-dimethylethyl)-5-isocyanato-, dimer ................................................................. C 

53880–05–0 ............... Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl-, homopolymer; Isophorone 

diisocyanate homopolymer.

E 

55525–54–7 ............... Urea, N,N′-bis[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]- ............................................................. E 

60732–52–7 ............... Carbamic acid, N,N ′-(3-isocyanatomethylphenyl)-, C,C′-(oxydi-2,1-ethanediyl) ester ............................ C 

65087–21–0 ............... Carbamic acid, N-[4-[(4-isocyanatocyclohexyl)methyl]cyclohexyl]-, C,C′-(oxydi-2,1-ethanediyl) ester ... E 

65104–99–6 ............... Imidodicarbonic diamide, 2,2′-[methylenebis(2-chloro-4,1-phenylene)]bis[N,N ′-bis(3-isocyanatomethylphenyl)-.C 

65105–00–2 ............... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C′-(1-methyl-1,3-propanediyl) ester ......................... C 

65105–02–4 ............... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C′-(1,4-butanediyl) ester .......................................... C 

67873–91–0 ............... 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]- ........ E 

68083–39–6 ............... Benzenamine, N,N′-methanetetraylbis[3-isocyanato-2,4,6-tris(1-methylethyl)- ....................................... C 

68092–73–9 ............... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C′-(1,2-ethanediyl) ester .......................................... C 

68092–74–0 ............... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C′-[oxybis(1-methyl-2,1-ethanediyl)] ester ............... C 

68133–14–2 ............... Carbamic acid, N-(3-isocyanatomethylphenyl)-, C,C′-[[[(diethoxyphosphinyl) methyl]imino]di-2,1- 

ethanediyl] ester.

C 

68239–06–5 ............... Cyclohexane, 2-heptyl-3,4-bis(9-isocyanatononyl)-1-pentyl- ................................................................... A, E 

68310–46–3 ............... Hexanoic acid, [[2-ethyl-2-[[[[[5-isocyanato-1(or 5)-(methoxycarbonyl)pentyl] amino]carbonyl]oxy] 

methyl]-1,3-propanediyl]bis(oxycarbonylimino)]bis[isocyanato-, 1,1′-dimethyl ester.

E 

68366–14–3 ............... Carbamic acid, N-[5-isocyanato-2(or 4)-methylphenyl]-, C,C′-(1-methyl-1,3-propanediyl) ester ............ C 

68555–56–6 ............... 1,3-Diazetidine-2,4-dione, 1,3-bis(4-isocyanato-3-methylphenyl)- ........................................................... C 

68975–84–8 ............... Carbamic acid, N-[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-, C,C′-(oxydi-2,1-ethanediyl) ester E 

69878–18–8 ............... Hexanoic acid, 2,6-diisocyanato-, 2-isocyanatoethyl ester ...................................................................... E 

70024–76–9 ............... Hexatriacontane, diisocyanato-, branched ............................................................................................... E 

70198–24–2 ............... Undecane, 1,6,11-triisocyanato- .............................................................................................................. E 

71130–76–2 ............... Urea, N-(3-isocyanatomethylphenyl)-N′-[[[4-[[[(3-isocyanatomethylphenyl) amino]carbonyl]amino] 

phenyl]methyl]phenyl]-.

C 

71832–70–7 ............... Carbamic acid, N-[4-[(4-isocyanatophenyl)methyl]phenyl]-, C,C′-(oxydi-2,1-ethanediyl) ester ............... C 

75790–84–0 ............... Benzene, 2-isocyanato-4-[(4-isocyanatophenyl)methyl]-1-methyl- .......................................................... C 

75790–87–3 ............... Benzene, 1-isocyanato-2-[(4-isocyanatophenyl)thio]- .............................................................................. C 

85702–90–5 ............... 2,9,11,13-Tetraazanonadecanethioic acid, 19-isocyanato-11-(6-isocyanatohexyl)-10,12-dioxo-, S-[3- 

(trimethoxysilyl)propyl] ester.

E 

106790–31–2 ............. Benzenamine, 4-isocyanato-N,N-bis(4-isocyanatophenyl)-2,5-dimethoxy- ............................................. C 

Notes: A—Previously added to the ITC’s Priority Testing List in the 26th ITC Report (Ref. 16). 

B—In the Toluene Diisocyanate (TDI) Action Plan (http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/tdi.pdf). 

C—One of the 29 aromatic diisocyanate compounds. 

D—In the Methylene Diphenyl Diisocyanate (MDI) Action Plan (http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/mdi.pdf). 

E—One of the 26 aliphatic diisocyanate compounds. 

B. Chemicals Removed From the Priority 

Testing List 

1. Cadmium compounds. As a result 

of EPA’s expanding the cadmium 

compounds category to include any 

chemical that contains cadmium as part 

of that chemical’s structure, the ITC is 

removing 103 cadmium compounds, but 

not cadmium from the Priority Testing 

List. The 103 cadmium compounds 

were listed in the 68th ITC Report (Ref. 

2). 

2. HPV Challenge Program orphan 

chemicals. Two hundred seventy HPV 

Challenge Program orphan chemicals 

were added to the Priority Testing List 

in the 55th ITC Report (Ref. 30) and 5 

were added to the Priority Testing List 

in the 56th ITC Report (Ref. 31). 

Thirty HPV Challenge Program 

orphan chemicals were removed from 

the Priority Testing List in the 56th ITC 

Report (Ref. 31). Eight HPV Challenge 

Program orphan chemicals were 

removed from the Priority Testing List in 

the 58th ITC Report (Ref. 76). Thirty-five 

HPV Challenge Program orphan 

chemicals were removed from the 

Priority Testing List in the 61st ITC 

Report (Ref. 39). One HPV Challenge 

Program orphan chemical was removed 

from the Priority Testing List in the 63rd 

ITC Report (Ref. 77). Twenty-nine HPV 

Challenge Program orphan chemicals 

were removed from the Priority Testing 

List in the 68th ITC Report (Ref. 2). 

Fourteen HPV Challenge Program 

orphan chemicals are being removed 

from the Priority Testing List because 

they were included in the EPA’s 

October 21, 2011 TSCA section 4 

proposed test rule (Ref. 3). These 14 

HPV Challenge Program orphan 

chemicals are listed in Table 7 of this 

unit. 

TABLE 7—FOURTEEN HPV CHALLENGE PROGRAM ORPHAN CHEMICALS BEING REMOVED FROM THE PRIORITY TESTING

LIST

CAS No. Chemical name 

98–16–8 ..................................................... Benzenamine, 3-(trifluoromethyl)-. 

124–63–0 ................................................... Methanesulfonyl chloride. 

460–00–4 ................................................... Benzene, 1-bromo-4-fluoro-. 

542–92–7 ................................................... 1,3-Cyclopentadiene. 

928–72–3 ................................................... Glycine, N-(carboxymethyl)-, disodium salt. 

28106–30–1 ............................................... Benzene, ethenylethyl-. 

35203–06–6 ............................................... Benzenamine, 2-ethyl-6-methyl-N-methylene-. 

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TABLE 7—FOURTEEN HPV CHALLENGE PROGRAM ORPHAN CHEMICALS BEING REMOVED FROM THE PRIORITY TESTING

LIST—Continued 

CAS No. Chemical name 

35203–08–8 ............................................... Benzenamine, 2,6-diethyl-N-methylene-. 

37734–45–5 ............................................... Carbonochloridothioic acid, S-(phenylmethyl) ester. 

37764–25–3 ............................................... Acetamide, 2,2-dichloro-N,N-di-2-propenyl-. 

65996–91–0 ............................................... Distillates (coal tar), upper. 

68153–60–6 ............................................... Fatty acids, tall-oil, reaction products with diethylenetriamine, acetates. 

68442–77–3 ............................................... 2-Butenediamide, (2E)-, N1,N4-bis[2-(4,5-dihydro-2-nortall-oil alkyl-1H-imidazol-1-yl)ethyl] derivs. 

68909–77–3 ............................................... Ethanol, 2,2′-oxybis-, reaction products with ammonia, morpholine derivs. Residues. 

V. References 

1. ITC. Fifty-Second Report of the ITC; 

Notice. Federal Register (68 FR 43608, 

July 23, 2003) (FRL–7314–4). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

2. ITC. Sixty-Eighth Report of the ITC; 

Notice. Federal Register (76 FR 46174, 

August 1, 2011) (FRL–8879–3). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

3. EPA. Certain High Production Volume 

Chemicals; Test Rule and Significant 

New Use Rule; Fourth Group of 

Chemicals; Proposed rule. Federal 

Register (76 FR 65580, October 21, 2011) 

(FRL–8876–6). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

4. ITC. Twenty-Eighth Report of the ITC; 

Notice. Federal Register (56 FR 41212, 

August 19, 1991) (FRL–3937–4). 

Available online at: http:// 

www.regulations.gov. ID number: EPA– 

HQ–OPPT–2011–1020. 

5. ITC. Thirty-Second Report of the ITC; 

Notice. Federal Register (58 FR 38490, 

July 16, 1993) (FRL–4630–2). (Available 

online at: http://www.regulations.gov. ID 

number: EPA–HQ–OPPT–2011–1020. 

6. ITC. Eleventh Report of the ITC; Notice. 

Federal Register (47 FR 54626, 

December 3, 1982) (FRL–2254–7). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

7. ITC. Thirteenth Report of the ITC; Notice. 

Federal Register (48 FR 55674, 

December 14, 1983) (FRL–2484–7). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

8. EPA. Bis(2-Ethylhexyl)Terephthalate; 

Response to the Interagency Testing 

Committee; Notice. Federal Register (48 

FR 51845, November 14, 1983) (FRL– 

2450–3). Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

9. Dreyfus, M. A. and Babich, M. A. 

Plasticizer migration from toys and child 

care articles. The Toxicologist, Vol. 20, 

abstract 1243, p. 266. Society of 

Toxicology. Reston, VA. 2011. Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

10. ITC. Eighteenth Report of the ITC; Notice 

Federal Register (51 FR 18368, May 19, 

1986) (FRL–3017–2). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

11. EPA. Addition of Chemicals to 

Information-Gathering Rules; Final rule. 

Federal Register (51 FR 18323, May 19, 

1986) (FRL–3017–3). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

12. ITC. Nineteenth Report of the ITC; Notice. 

Federal Register (51 FR 41417, 

November 14, 1986) (FRL–3109–7). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

13. ITC. Twenty-second Report of the ITC; 

Notice. Federal Register (53 FR 18196, 

May 20, 1988) (FRL–3381–7). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

14. EPA. Tributyl Phosphate; Proposed Test 

Rule. Federal Register (52 FR 43346, 

November 12, 1987) (FRL–3289–6). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

15. EPA. Tributyl Phosphate; Final Test Rule. 

Federal Register (54 FR 33400, August 

14, 1989) (FRL–3627–4). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

16. ITC. Twenty-Sixth Report of the ITC; 

Notice. Federal Register (55 FR 23050, 

June 5, 1990) (FRL–3765–4). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

17. EPA. Preliminary Assessment 

Information and Health and Safety Data 

Reporting; Addition of Chemicals; Final 

rule. Federal Register (55 FR 39780, 

September 28, 1990) (FRL–3773–3). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

18. ITC. Thirty-Third Report of the ITC; 

Notice. Federal Register (59 FR 3764, 

January 26, 1994) (FRL–4750–9). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

19. ITC. Second Report of the ITC; Notice. 

Federal Register (43 FR 16684, April 19, 

1978) (FRL–884–7). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

20. EPA. Chemical Information Rules; 

Manufacturers Reporting; Preliminary 

Assessment Information; Final rule. 

Federal Register (47 FR 26992, June 22, 

1982) (FRL–2039–7). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

21. EPA. Health and Safety Data Reporting; 

Submission of Lists and Copies of Health 

and Safety Studies; Final rule. Federal 

Register (47 FR 38780, September 2, 

1982) (FRL–2112–2). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

22. ITC. Fourteenth Report of the ITC; Notice. 

Federal Register (49 FR 22389, May 29, 

1984) (FRL–2594–4). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

23. EPA. Aryl Phosphates; Response to the 

Interagency Testing Committee; 

Advanced Notice of Proposed 

Rulemaking. Federal Register (48 FR 

57452, December 29, 1983) (FRL–2458– 

1). Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

24. EPA. Aryl Phosphate Base Stocks; 

Proposed Test Rule Including Reporting 

and Recordkeeping Requirements. 

Federal Register (57 FR 2138, January 

17, 1992) (FRL–3883–4). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

25. ITC. Twenty-Third Report of the ITC; 

Notice. Federal Register (53 FR 46262, 

November 16, 1988) (FRL–3476–6). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

26. EPA. Preliminary Assessment 

Information and Health and Safety Data 

Reporting; Addition of Chemicals; Final 

rule. Federal Register (53 FR 46279, 

November 16, 1988) (FRL–3476–3). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

27. ITC. Thirty-Sixth Report of the ITC; 

Notice. Federal Register (60 FR 42982, 

August 17, 1995) (FRL–4965–6). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

28. ITC. Thirtieth Report of the ITC; Notice. 

Federal Register (57 FR 30608, July 9, 

1992) (FRL–4071–4). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

29. EPA. Preliminary Assessment 

Information and Health and Safety Data 

Reporting; Addition of Chemicals; Final 

rule. Federal Register (58 FR 28511, May 

mstockstill on DSK4VPTVN1PROD with NOTICES2

30868 Federal Register / Vol. 77, No. 100 / Wednesday, May 23, 2012 / Notices 

14, 1993) (FRL–4182–1). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

30. ITC. Fifty-Fifth Report of the ITC; Notice. 

Federal Register (70 FR 7364, February 

11, 2005) (FRL–7692–1). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

31. ITC. Fifty-Sixth Report of the ITC; Notice. 

Federal Register (70 FR 61520, October 

24, 2005) (FRL–7739–9). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

32. ITC. Twenty-Seventh Report of the ITC; 

Notice. Federal Register (56 FR 9534, 

March 6, 1991) (FRL–3845–3). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

33. ITC. Forty-Fifth Report of the ITC; Notice. 

Federal Register (65 FR 75544, 

December 1, 2000) (FRL–6399–5). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

34. ITC. Thirty-Fifth Report of the ITC; 

Notice. Federal Register (59 FR 67596, 

December 29, 1994) (FRL–4923–2). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

35. EPA. Proposed Test Rule for In Vitro 

Dermal Absorption Rate Testing of 

Certain Chemicals of Interest to 

Occupational Safety and Health 

Administration. Federal Register (64 FR 

31074, June 9, 1999) (FRL–5760–3). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

36. EPA. Acetophenone, Phenol, N,NDimethylaniline, Ethyl Acetate and 2,6- 

Dimethylphenol; Proposed Test Rule, 

Notice of Opportunity to Initiate 

Negotiations for TSCA Section 4 Testing 

Consent Agreements. Federal Register 

(58 FR 61654, November 22, 1993) (FRL– 

4010–2). Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

37. ITC. First Report of the ITC; Notice. 

Federal Register (42 FR 55026, October 

12, 1977). Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

38. EPA. Cresols; Proposed Test Rule. 

Federal Register (48 FR 31812, July 11, 

1983) (FRL–2341–2). Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

39. ITC. Sixty-First Report of the ITC; Notice. 

Federal Register (73 FR 5080, January 

28, 2008) (FRL–8347–1). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

40. ITC. Sixty-Second Report of the ITC; 

Notice. Federal Register (73 FR 27450, 

May 12, 2008) (FRL–8363–2). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

41. National Institute for Occupational Safety 

and Health (NIOSH). Preventing Asthma 

and Death from MDI Exposure during 

Spray-on Truck Bed Liner and Related 

Applications: NIOSH Alert. DHHS 

(NIOSH) Publication Number 2006–149. 

September 2006. Available online at: 

http://www.cdc.gov/niosh/docs/2006- 

149. 

42. Ott, M. G., Diller, W. F., and Jolly, A.T. 

2003. Respiratory Effects of Toluene 

Diisocyanate in the Workplace: A 

Discussion of Exposure-Response 

Relationships. Critical Reviews in 

Toxicology. 33: 1–59. Available online 

at: http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

43. Bello, D., Woskie, S. R., Streicher, R. P., 

Liu, Y., Stowe, M. H., Eisen, E. A., 

Ellenbecker, M. J., Sparer, J., Youngs, F., 

Cullen, M. R., and Redlich, C. A. 2004. 

Polyisocyanates in Occupational 

Environments: A Critical Review of 

Exposure Limits and Metrics. American 

Journal of Industrial Medicine. 46: 480– 

491. Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

44. Bernstein, D. I., Korbee, L., Stauder, T., 

Bernstein, J. A., Scinto, J., Herd, Z. L., 

and Bernstein, I. L. 1993. The low 

prevalence of occupational asthma and 

antibody-dependent sensitization to 

diphenylmethane diisocyanate in a plant 

engineered for minimal exposure to 

diisocyanates. Journal of Allergy and 

Clinical Immunology. 92: 387–396. 

Available on online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

45. Ulvestad, B., Melbostad, E., and Fuglerud, 

P. 1999. Asthma in tunnel workers 

exposed to synthetic resins. 

Scandinavian Journal of Work, 

Environment & Health. 25(4): 335–341. 

Available online at: http://

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

46. Petsonk, E., Wang, M., Lewis, D., Siegel, 

P., and Husberg, B. 2000. Asthma-Like 

Symptoms in Wood Product Plant 

Workers Exposed to Methylene Diphenyl 

Diisocyante. Chest. 118: 1183–1193. 

Available online at: http://

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

47. Sommer, B. G., Sherson, D. L., Kjoller, H., 

Hansen, I., Clausen, G., and Jepsen, J. R., 

2000. Asthma caused by methylenediphenyl-diisocyanate cast in a nurse. 

Ugeskr Lateger 162(4): 505–506 as cited 

in Bello, D., Herrick, C. A., Smith, T. J., 

Woskie, S. R., Streicher, R. P., Cullen, 

M.R., Liu, Y., and Redlich, C.A. 2007. 

Skin Exposure to Isocyanates: Reasons 

for Concern. Environmental Health 

Perspectives. 115: 328–335. Available on 

line at: http://ehp03.niehs.nih.gov/

article/fetchArticle.action?articleURI=

info%3Adoi%2F10.1289%2Fehp.9557. 

48. Donnelly, R., Buick, J. B., and Macmahon, 

J. 2003. Occupational asthma after 

exposure to plaster casts containing 

methylene diphenyl diisocyanate. 

Occupational Medicine. 53: 432–434. 

Available online at: http://

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

49. Redlich, C. A., Bello, D., and Wisnewski, 

A. 2006. Isocyanate Exposures and 

Health Effects. Environmental and 

Occupational Medicine (W. Rom and S. 

Markowitz, Eds.), pp. 502–516. 

Lippincott Williams & Wilkins. 

Philadelphia, PA. Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

50. NIOSH. Preventing Asthma and Death 

from Diisocyanate Exposure: NIOSH 

Alert. DHHS (NIOSH) Publication 

Number 96–111. 1996. Available online 

at: http://www.cdc.gov/niosh/docs/96- 

111. 

51. American Chemistry Council (ACC). 

TSCA 8(e) Notice of Substantial Risk 

8EHQ–0905–16225 Fatalities linked to 

diisocyanates. EPA. September 2005. 

Available online at: http://

www.regulations.gov. Docket ID Number: 

EPA–HQ–OPPT–2011–1020. 

52. O’Brien, I. M., Harries, M. G., Burge, P. 

S., and Pepys, J. 1979. Toluene diisocyanate-induced asthma I. Reactions 

to TDI, MDI, HDI and histamine. Clinical 

& Experimental Allergy. 9: 1–6. 

Available online at: http://

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

53. International Agency for Research on 

Cancer (IARC). 1987. 4,4′- 

Methylenediphenyl Diisocyanate and 

Polymeric 4,4′-Methylenediphenyl 

Diisocyanate. Vol. 71, Monographs 71– 

47, pp. 1049–1058. Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

54. European Chemicals Bureau (ECB). 2005. 

European Union Risk Assessment Report 

methylenediphenyl diisocyanate (MDI). 

Available online at: http://

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

55. Collins, M. A. 2002. Toxicology of 

Toluene Diisocyanate. Applied 

Occupational and Environmental 

Hygiene. 17: 846–855. Available online 

at: http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

56. OECD. Screening Information Data Set 

(SIDS) Initial Assessment Report for 12th 

SIAM: Hexamethylene Diisocyanate CAS 

No: 822–06–0 (HDI). June 2001. pp. 1– 

73. United National Environment 

Programme (UNEP). Paris, France. 

Available online at: http://

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

57. Bayer Material Science. 2009. FYI 1209– 

01618. Available online at: http://

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

58. Crespo, J. and Galan, J. 1999. Exposure to 

MDI During the process of insulating 

buildings with sprayed polyurethane 

foam. Annals of Occupational Hygiene. 

43: 415–419. Available online at: http://

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

59. Occupational Health and Safety Research 

Institute. 2009. 4,4′-Diphenylmethane 

diisocyanate (MDI) safety practices and 

concentration during polyurethane foam 

spraying. R–629, pp. 1–66. Available 

mstockstill on DSK4VPTVN1PROD with NOTICES2

Federal Register / Vol. 77, No. 100 / Wednesday, May 23, 2012 / Notices 30869 

online at: http://www.irsst.qc.ca/files/

documents/PubIRSST/R-629.pdf. 

60. Lesage, J., Stanley, J., Karoly, W. J., and 

Lichtenberg, F. W. 2007. Airborne 

Methylene Diphenyl Diisocyanate (MDI) 

Concentrations Associated with the 

Application of Polyurethane Spray Foam 

in Residential Construction. Journal of 

Occupational and Environmental 

Hygiene. 4: 145–155. Available online at: 

http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

61. Kelly, T. J., Myers, J. D., and Holdren, M. 

W. 1999. Testing of Household Products 

and Materials for Emission of Toluene 

Diisocyanate. Indoor Air. 9: 117–124. 

Available online at: http:// 

www.regulations.gov. Docket ID Number: 

EPA–HQ–OPPT–2011–1020. 

62. Jarand, C. W., Akapo, S. O., Swenson, L. 

J., and Kelman, B. J. 2002. Diisocyanate 

Emission from a Paint Product: A 

Preliminary Analysis. Applied 

Occupational and Environmental 

Hygiene. 17: 491–494. Available online 

at: http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

63. New York City Department of Health and 

Mental Hygiene (NYC–DOHMH). 

Environmental Investigation of Chemical 

Ingredients of Moisture Cure Urethanes 

Used as Wood Floor Coatings. May 20, 

2003. Available online at:http:// 

home2.nyc.gov/html/doh/downloads/ 

pdf/epi/epi-mcu-report.pdf. 

64. Luo, J., Nelsen K., and Fischbein, A. 

1990. Persistent reactive airway 

dysfunction syndrome after exposure to 

toluene diisocyanate. British Journal of 

Industrial Medicine. 47: 239–241. 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020–0064. 

65. Zotti, R., Muran, A., and Zambon, F., 

2000. Two cases of paraoccupational 

asthma due to toluene diisocyanate 

(TDI). Occupational and Environmental 

Medicine. 57: 837–839. Available online 

at: http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

66. Woskie, S., Sparer, J., Gore, R., Stowe, M., 

Bello, D., Liu, Y., Youngs, F., Redlich, C., 

Eisen, E., and Cullen M. 2004. 

Determinants of Isocyanate Exposures in 

Auto Body Repair and Refinishing 

Shops. Annals of Occupational Hygiene. 

Vol. 48, No. 5, 393–403. Available online 

at: http://www.regulations.gov. Docket ID 

number: EPA–HQ–OPPT–2011–1020. 

67. Jan, R. L., Chen, S. H., Chang, H. Y., Yeh, 

H. J., Shieh, C. C., and Wang, J. Y. 2008. 

Asthma-like syndrome in school 

children after accidental exposure to 

xylene and methylene diphenyl 

diisocyanate. Journal of Microbiology, 

Immunology and Infection. 41: 337–341. 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

68. National Institutes of Health (NIH). 

Asthma in Children. Medline Plus. 

October 13, 2011. Available online at: 

http://www.nlm.nih.gov/medlineplus/ 

asthmainchildren.html. 

69. Trasande, L. and Thurston, G. 2005. The 

role of air pollution in asthma and other 

pediatric morbidities. Journal of Allergy 

and Clinical Immunology. 115: 689–699. 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

70. Bayer, A.G. 1992. Determination on the 

ecological behavior of Desmodur W. 

Unpublished Report 218 A/90 1992–05– 

29. As cited in SIDS Initial Assessment 

Report For SIAM 20, Paris, France. April 

19–22, 2005. Available online at: http:// 

www.alipa.org/uploads/Modules/ 

Publications/ 

OECD_DraftSIDS_5124301.pdf. 

71. Bayer, A.G. 2000b. Fish test. Unpublished 

Report 858 A/99 F, 2000–01–07. As cited 

in SIDS Initial Assessment Report For 

SIAM 20, Paris, France. April 19–22, 

2005. Available online at: http:// 

www.alipa.org/uploads/Modules/ 

Publications/ 

OECD_DraftSIDS_5124301.pdf. 

72. Bayer, A.G. 2000c. Daphnia test. 

Unpublished Report 858 A/99 D, 2000– 

01–06. As cited in SIDS Initial 

Assessment Report For SIAM 20, Paris, 

France. April 19–22, 2005. Available 

online at: http://www.alipa.org/uploads/ 

Modules/Publications/ 

OECD_DraftSIDS_5124301.pdf. 

73. Bayer, A.G. 2000d. Algal test. 

Unpublished Report 858 A/99 Al, 2000– 

01–06. As cited in SIDS Initial 

Assessment Report For SIAM 20, Paris, 

France. April 19–22, 2005. Available 

online at: http://www.alipa.org/uploads/ 

Modules/Publications/ 

OECD_DraftSIDS_5124301.pdf. 

74. Van der Hoeven, N., Roza, P., and 

Henzen, L. 1992a. Determination of the 

effect of TDI, TDA, MDI, and MIDA on 

the emergence and growth of the plant 

species Avena sativa and Lactuca sativa 

according to OECD Guideline No. 208. 

TNO. 111 Report No. 11024. Available 

from: British Library Document Supply 

Centre, Boston Spa, Wetherby, West 

Yorkshire. As cited in Allport, D., 

Gilbert, D., and Outterside, S. 2003. MDI 

and TDI: Safety, Health and the 

Environment. John Wiley & Sons, Ltd. 

West Sussex, England, 264. Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

75. Van der Hoeven, N., Roza, P., and 

Henzen, L., 1992b. Determination of the 

LC50 (14 days) of TDI, TDA, MDI, and 

MDA to the earthworm Eisenia fetida 

according to OECD guideline No. 207. 

TNO. 111 Report No. 11025. Available 

from: British Library Document Supply 

Centre, Boston Spa, Wetherby, West 

Yorkshire. As cited in Allport, D., 

Gilbert, D., and Outterside, S. 2003. MDI 

and TDI: Safety, Health and the 

Environment. John Wiley & Sons, Ltd. 

West Sussex, England, 265. Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

76. ITC. Fifty-Eighth Report of the ITC; 

Notice. Federal Register (71 FR 39188, 

July 11, 2006) (FRL–8073–7). Available 

online at: http://www.regulations.gov. 

Docket ID number: EPA–HQ–OPPT– 

2011–1020. 

77. ITC. Sixty-Third Report of the ITC; 

Notice. Federal Register (73 FR 65486, 

November 3, 2008) (FRL–8387–6). 

Available online at: http:// 

www.regulations.gov. Docket ID number: 

EPA–HQ–OPPT–2011–1020. 

VI. The TSCA Interagency Testing 

Committee 

Statutory Organizations With Representatives 

Department of Commerce, National Institute 

of Standards and Technology 

Dianne L. Poster, Alternate.

Environmental Protection Agency 

Robert W. Jones, Member. 

John E. Schaeffer, Alternate. 

National Institute of Environmental Health 

Sciences 

Nigel Walker, Member. 

Scott Masten, Alternate. 

National Institute for Occupational Safety 

and Health 

Gayle DeBord, Member. 

Dennis W. Lynch, Alternate. 

Occupational Safety and Health 

Administration 

Thomas Nerad, Member. 

Janet Carter, Alternate. 

Liaison Organizations With Representatives 

Agency for Toxic Substances and Disease 

Registry 

Glenn D. Todd, Member. 

Consumer Product Safety Commission 

Dominique Johnson, Member. 

Department of Agriculture 

Clifford P. Rice, Member. 

Department of Defense 

Laurie E. Roszell, Member. 

Department of the Interior 

Barnett A. Rattner, Member. 

Food and Drug Administration 

Kirk Arvidson, Member. 

Ronald F. Chanderbhan, Alternate. 

ITC Staff 

John D. Walker, Director. 

Carol Savage, Administrative Assistant 

(NOWCC Employee). 

TSCA Interagency Testing Committee 

(7401M), Office of Pollution Prevention and 

Toxics, Environmental Protection Agency, 

1200 Pennsylvania Ave. NW., Washington, 

DC 20460–0001; email address: 

savage.carol@epa.gov; url: http:// 

www.epa.gov/opptintr/itc. 

[FR Doc. 2012–12493 Filed 5–22–12; 8:45 am] 

BILLING CODE 6560–50–P 

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