Exhibit 10.183

LICENSE AGREEMENT

This agreement ("Agreement") is entered into by and between the University of Iowa Research Foundation ("UIRF"), located at 214 Technology Innovation Center, Iowa
City, IA 52242 and MedImmune, Inc., ("MedImmune") having a place of business at 35 West Watkins Mill Road, Gaithersburg, Maryland 20878.

WHEREAS,
UIRF is owner by assignment from Prof. Mark F. Stinski, of U.S. Patent Nos. 5,168,062 and 5,385,839, issued December 1, 1992, and January 31, 1995 respectively,
titled "Transfer Vectors and Microorganisms containing Human Cytomegalovirus (HCMV) Immediate-Early Promoter-Regulatory DNA Sequence" (no foreign filings have been undertaken by the UIRF);

WHEREAS,
MedImmune desires a non-exclusive license to the above United States patents for their use in the production of proteins;

WHEREAS,
UIRF wishes to grant such a license in accordance with the terms of this Agreement.

NOW
THEREFORE, the parties agree as follows:

ARTICLE IDEFINITIONS

1.1  Licensed
Patents shall mean U.S. Patent Nos. 5,168,062 and 5,385,839, issued December 1, 1992, and January 31, 1995 respectively, titled "Transfer Vectors
and Microorganisms containing Human Cytomegalovirus (HCMV) Immediate-Early Promoter-Regulatory DNA Sequence", by Prof. Mark F. Stinski, or any U.S. patents issuing thereon, including any
continuations, continuations-in-part, divisions, reissues, reexaminations and extensions thereof and patents corresponding thereto.

1.2  Licensed
Products shall mean and include any and all biological materials and products and processes the making, having made, using, selling or importing of which would,
but for this Agreement, constitute an infringement of one or more Valid Claims of the Licensed Patents.

1.3  Valid
Claim shall mean any claim in an unexpired patent included within Licensed Patents which claim has not been disclaimed or held invalid or unenforceable by an
unappealed or unappealable decision of a court.

1.4  Licensed
Field shall mean the use of the Licensed Patents and the making, having made, using, selling or importing of the Licensed Products in the production of proteinsby cell culture. Licensed Field
specifically excludes any use of the Licensed Patents or use and/or sale of Licensed Products for
gene therapy applications and genetic immunization or DNA-based vaccines.

1.5  Licensed
Territory shall mean any country in which the making, having made, using, selling or importing of Licensed Products would, but for the license granted in this
Agreement, infringe one or more Valid Claims of the Licensed Patents.

1.6  Net
Sales shall mean the gross amount received by MedImmune and/or its Affiliates from the sales of Licensed Products within the Licensed Field in the Licensed Territory
to third party customers less:



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On
sales between MedImmune and its Affiliates for resale, the royalty shall be paid on the resale.

1.7  Effective
Date shall mean December 1, 1997.

1.8  Yearly
Accounting Period shall mean an annual period beginning on January 1 and ending on December 31 of the same year.

1.9  Earned
Royalties shall mean royalties paid or payable by MedImmune and/or its Affiliates to UIRF as determined with respect to Net Sales.

1.10 Affiliate
shall mean any corporation owning or controlling, directly or indirectly, at least forty-nine (49%) of the stock normally entitled to vote for
election of directors of a party.

1.11 For
purposes of this Agreement, Partner shall mean any third party company or legal entity which is not controlled by or under common control with MedImmune, with which
MedImmune has a joint venture or collaboration or marketing/distribution or such other formal arrangement providing the third party company the right to co-manufacture,
co-develop, co-promote or co-market Licensed Products in the Licensed Field in conjunction with MedImmune.

ARTICLE IITHE GRANT

2.1  UIRF
hereby grants to MedImmune and its Affiliates, subject to the terms and conditions hereof, a non-exclusive license under Licensed Patents to make, have
made, use, import, sell, offer to sell, have sold the Licensed Products within the Licensed Field in the Licensed Territory.

2.2  To
ensure that any Partner (as defined in paragraph 1.11) has the appropriate enabling rights to make, have made, use, sell and import the Licensed Products in
the Licensed Field, MedImmune shall
direct its Partner to enter into a direct license with the UIRF for the Licensed Patents in the Licensed Field as outlined below:



Since
(a) the UIRF has granted a number of non-exclusive licenses to the Licensed Patents and (b) there exist several inter-relationships between UIRF's licensees and
licensees' affiliates, the Partners of MedImmune may already have enabling licenses for the Licensed Patents within the Licensed Field. Additionally, since UIRF will get delayed notification of the
nature of the relationship between MedImmune and its Partner, UIRF cannot be the party determining whether any of MedImmune's Partners have such enabling licenses already. The UIRF will not
intentionally collect any double payments; however, all payments made to UIRF are non-refundable and UIRF shall not be held responsible for any double payments that are made by MedImmune
and/or its Partners.

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ARTICLE IIIPAYMENTS, REPORTS, RECORD-KEEPING

3.1  In
consideration of the rights granted to MedImmune pursuant to Article 2.1 of this Agreement, MedImmune agrees to make the following payments to the UIRF:



3.2  In
the event that MedImmune becomes obligated at any time or from time to time during the term of this Agreement to pay royalties to any third party for the practice of
any method or use of any composition of matter covered by any claim of the Licensed Patents or for the sale of any Licensed Products, MedImmune's royalty obligation to the UIRF shall be reduced by an
amount equal to its royalty obligation to such third party; provided, however, that MedImmune's royalty obligation shall not be reduced by more than fifty percent (50%) for any one calendar quarter.

3.3  MedImmune's
obligation to make payments hereunder shall be suspended during any period of time that MedImmune is enjoined, or reasonably believes it may be enjoined,
from exercising any of its rights hereunder with respect to the Licensed Patents or any Licensed Products. Upon resolution of any such matter, MedImmune shall promptly pay to UIRF all amounts
previously withheld with respect to such matter, less (i) any reduction which may be applicable pursuant to paragraph above, and (ii) expenses incurred in the resolution thereof.

3.4  MedImmune
shall report, not any less frequently than annually, on its efforts and progress made toward commercialization of any products involving Licensed Patents.

3.5  MedImmune
shall keep accurate and correct records of Licensed Products made, used or sold under this Agreement. Such records shall be retained for at least three
(3) years following a given reporting period. UIRF is hereby granted by MedImmune the right, upon reasonable written notice to MedImmune and appropriately bound by confidentiality, to retain an
independent certified public accountant reasonably acceptable to MedImmune to audit MedImmune's records solely to verify sales
of the Licensed Products. UIRF may designate an agent for purposes of this verification and this verification shall be upon reasonable notice to MedImmune.

3.6  All
payments due hereunder shall be payable in United States dollars. Conversion of foreign currency to U.S. dollars shall be made at the conversion rate existing in the
United States as reported in The Wall Street Journal on the last working day of each royalty period. Such payments shall be without deduction of exchange, collection or other charges.

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3.7  Late
payments shall be subject to an interest charge of one and one-half percent (1.5%) per month.

ARTICLE IVTERM AND TERMINATION

4.1  Unless
terminated earlier in accordance with this Agreement, the term of the license granted hereunder shall expire upon the expiration of the last to expire of the
Licensed Patents.

4.2  In
the event MedImmune fails to make payments due hereunder, UIRF shall have the right to terminate this Agreement upon forty-five (45) days written
notice, unless MedImmune makes such payments plus interest within the forty-five (45) day notice period.

4.3  In
the event that MedImmune shall become insolvent, shall make an assignment for the benefit of its creditors, or shall have a petition in bankruptcy filed for or
against it and such petition shall not have been discharged within ninety (90) days, UIRF may, at its option, terminate this license upon thirty (30) days written notice.

4.4  MedImmune
shall have the right to terminate this Agreement at any time by written notice to UIRF to that effect.

4.5  MedImmune
shall have the right during a period of six (6) months following the effective date of such termination to sell or otherwise dispose of the Licensed
Products existing at the time of such termination, and shall make a final report and payment of all royalties related thereto within sixty
(60) days following the end of such period or the date of the final disposition of such inventory, whichever first occurs.

ARTICLE VASSIGNMENT

5.1  This
Agreement may be assigned by MedImmune as part of a transfer of all, or substantially all, of the business to which this Agreement relates. This Agreement shall be
binding upon and inure to the benefit of successors in interest and assigns of MedImmune. MedImmune agrees to inform UIRF of such transfer promptly.

ARTICLE VIREPRESENTATIONS: LIMITATIONS

6.1  Nothing
in this Agreement shall be construed as:



6.2  UIRF
expressly disclaims any and all implied or express warranties and makes no express or implied warranties of merchantability or fitness for any particular purpose of
the Licensed Patent, Biological Materials or Licensed Processes or Licensed Products contemplated by this Agreement.

ARTICLE VIIGENERAL

7.1  MedImmune
shall not distribute or resell the Licensed Products to others except in accordance with the rights granted under Article II of this Agreement.
MedImmune agrees to comply with all applicable laws and regulations.

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7.2  UIRF
shall have the responsibility for the prosecution, filing and maintenance of all Licensed Patents, including the conduct of all interference, opposition, nullity
and revocation proceedings, as well as responsibility for all fees and costs associated therewith.

7.3  A
party shall inform the other of any suspected infringement of any Licensed Patents in the Licensed Field by a third party. UIRF shall have the right but not the
obligation at its expense to initiate any proceeding relating to any infringement by a third party of any Licensed Patents in the Licensed Field.

7.4  UIRF
shall have no obligation to defend any action for infringement brought against MedImmune by a third party.

7.5  The
relationship between UIRF and MedImmune shall be that of independent contractors. UIRF and MedImmune shall have no other relationship other than as independent
contracting parties. UIRF shall have no power to bind or obligate MedImmune in any manner, except as is expressly set forth in this Agreement.

7.6  MedImmune
shall indemnify and hold harmless UIRF and UI and their employees and officers and their respective successors, heirs and assigns, from any action, claim or
liability, including, without limitation, liability for death, personal injury, or property damages arising directly or indirectly from MedImmune's possession, distribution or other use of Licensed
Products under this Agreement and/or from MedImmune's publication or distribution of test reports, data and other information relating to Licensed Products, provided:



7.7  If
any provision of this Agreement is ultimately held to be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions
shall not in any way be affected or impaired thereby.

7.8  Any
delay in enforcing a party's rights under this Agreement or any waiver as to a particular default or other matter shall not constitute a waiver of a party's right to
the future enforcement of its rights under this Agreement, except in the event of written and signed waiver.

7.9  The
captions herein are solely for convenience of reference and shall not affect the construction or interpretation of this Agreement.

ARTICLE VIIINOTICES; APPLICABLE LAW

8.1  Any
notice, report or payment provided for in this Agreement shall be deemed sufficiently given when sent by facsimile or regular, certified or registered mail addressed
to the party for whom

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intended at the following addresses, or to such address as either party may hereafter designate in writing to the other:

For
UIRF: University of Iowa Research Foundation, Attn: Ms. Usha R. Balakrishnan, Associate Director
214 Technology Innovation Center, Iowa City, IA 52242-5000
Phone: 319-335-4546/Fax: 319-335-4489

For
MedImmune: MedImmune, Inc., Attn: President
35 West Watkins Mill Road, Gaithersburg, Maryland 20878
        with a copy to: Michael Richman, Vice President, Business Development

8.2  This
agreement shall be construed, interpreted, and applied in accordance with the laws of the State of Iowa.

ARTICLE IXINTEGRATION

9.1  This
Agreement contains the entire agreement of the parties with respect to the subject matter hereof, all prior understandings relating thereto being merged herein.
This Agreement cannot be changed or terminated orally, but only in writing and if signed by both parties. This Agreement shall be binding on the heirs, successors, and assigns of the parties hereto.

|AGREED to:                                              |  |                                      |  |    
|------------------------------------------------------- |  | ------------------------------------ |  | ---
|LICENSOR                                                |  | LICENSEE                            
|University of Iowa Research Foundation                  |  | MedImmune, Inc.                     
|By:                                                     |  | /s/W. BRUCE WHEATON, PH.D.           |  | By:
|Date: December 9, 1997                                  |  | Date: December 12, 1997             
|Name: W. Bruce Wheaton, Ph.D.
Title: Executive Director |  | Name: David M. Mott
Title: President

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EXHIBIT A

LICENSE
TERMS FOR CMV PROMOTER PATENTS
For protein production field
U.S. Patent Nos. 5,168,062 and 5,385,839, by Mark Stinski
License available from the University of Iowa Research Foundation (UIRF)

|1. Licensed Patents |  | U.S. Patent No. 5,168,062 titled "Transfer Vectors and Microorganisms containing Human Cytomegalovirus (HCMV) Immediate-Early Promoter-Regulatory DNA Sequence", by Prof. Mark F. Stinski, issued December 1, 1992,
its continuations and divisionals (no international filings have been undertaken by the UIRF); and U.S. Patent No. 5,385,839, titled "Transfer Vectors and Microorganisms containing Human Cytomegalovirus (HCMV) Immediate-Early Promoter Regulatory
DNA Sequence" by Prof. Mark F. Stinski, issued January 31, 1995.
|------------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|2. License          |  | Non-exclusive, for licensed field of use                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
|3. Licensed field   |  | PRODUCTION OF PROTEINS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|4. License fee      |  | (CONFIDENTIAL TREATMENT REQUESTED), payable upon execution of the License Agreement                                                                                                                                                                                                                                                                                                                                                                                                                                                       
|5. Royalties        |  | (CONFIDENTIAL TREATMENT REQUESTED) on Sales, payable semi-annually                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|6. Maintenance fees |  | (CONFIDENTIAL TREATMENT REQUESTED), payable annually on each anniversary date of the License Agreement.                                                                                                                                                                                                                                                                                                                                                                                                                                   

Note:
The above terms are valid only if the license agreement is executed on or before December 1, 1998.

Contact
person for licensing interest for this or any other field of use license:

Ms. Usha
R. Balakrishnan
Associate Director
University of Iowa Research Foundation
214 Technology Innovation Center
Iowa City, Iowa 52242
Phone: 319-335-4546
Fax: 319-335-4489

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