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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-QSB

(Mark One)



|x | QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ---------------------------------------------------------------------------------

For the quarterly period ended June 30, 2006



| ̈ | TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE EXCHANGE ACT
|- | ---------------------------------------------------------------

For the transition period from  to

Commission
file number: 001-32836

MEDIVATION, INC.

(Exact name of small business issuer as specified in its charter)



|                                                               |  |                                  
|-------------------------------------------------------------- |  | ---------------------------------
|Delaware                                                       |  | 13-3863260                       
|(State or other jurisdiction of incorporation or organization) |  | (IRS Employer Identification No.)

55 Hawthorne Street, Suite 610

San Francisco, California 94105

(Address of principal executive offices)

(415) 543-3470

(Issuers telephone number)



Check whether the issuer
(1) filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the past 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days. Yes  x    No ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ̈No  x

State the
number of shares outstanding of each of the issuers classes of common equity, as of the latest practicable date:

As of August 8, 2006,
25,295,047 shares of Common Stock, $0.01 par value per share, were issued and outstanding.

Transitional Small Business Disclosure Format (Check one):
Yes ̈No  x



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PART I  FINANCIAL INFORMATION



|Item 1. | Financial Statements.
|------- | ---------------------

MEDIVATION,
INC.

(A DEVELOPMENT STAGE COMPANY)

CONDENSED CONSOLIDATED BALANCE SHEET (unaudited)



|                                                                                                                |  |               |             |  
|--------------------------------------------------------------------------------------------------------------- |  | ------------- | ----------- | -
|                                                                                                                |  | Jun. 30, 2006 |            
|ASSETS                                                                                                          |  |               |             |  
|Current assets:                                                                                                 |  |               |             |  
|Cash and cash equivalents                                                                                       |  | $             | 8,988,311   |  
|Short-term investments                                                                                          |  |               | 11,389,303  |  
|Prepaid expenses and other current assets                                                                       |  |               | 364,222     |  
|                                                                                                                |  |               |             |  
|Total current assets                                                                                            |  |               | 20,741,836  |  
|Property and equipment (net of accumulated depreciation of $1,096)                                              |  |               | 7,667       |  
|Intellectual property (net of accumulated amortization of $17,718)                                              |  |               | 64,944      |  
|Other assets                                                                                                    |  |               | 36,901      |  
|                                                                                                                |  |               |             |  
|Total assets                                                                                                    |  | $             | 20,851,348  |  
|                                                                                                                |  |               |             |  
|LIABILITIES AND STOCKHOLDERS EQUITY                                                                            |  |               |             |  
|Current liabilities:                                                                                            |  |               |             |  
|Accounts payable                                                                                                |  | $             | 1,192,949   |  
|Taxes payable                                                                                                   |  |               | 800         |  
|Series A redeemable preferred stock                                                                             |  |               | 11,000      |  
|                                                                                                                |  |               |             |  
|Total current liabilities                                                                                       |  |               | 1,204,749   |  
|Stockholders equity:                                                                                           |  |               |             |  
|Preferred stock, $0.01 par value per share; 1,000,000 shares authorized; no shares issued and outstanding       |  |               |            |  
|Common stock, $0.01 par value per share; 50,000,000 shares authorized; 25,295,047 shares issued and outstanding |  |               | 252,950     |  
|Additional paid-in capital                                                                                      |  |               | 39,873,914  |  
|Deferred compensation                                                                                           |  |               | (1,384,617  | )
|Deficit accumulated during the development stage                                                                |  |               | (19,095,648 | )
|                                                                                                                |  |               |             |  
|Total stockholders equity                                                                                      |  |               | 19,646,599  |  
|                                                                                                                |  |               |             |  
|Total liabilities and stockholders equity                                                                      |  | $             | 20,851,348  |  
|                                                                                                                |  |               |             |  

See accompanying notes to condensed consolidated financial statements



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MEDIVATION, INC.

(A DEVELOPMENT STAGE COMPANY)

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (unaudited)



|                                            |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|------------------------------------------- |  | --------------------------- | ---------- | - | ------------------------- | - | ---------- | -------------------------------------------- |  | - | ---------- | - |  | - | ---------- | - |  | - | ----------- | -
|                                            |  | Three months ended Jun. 30, |            |   | Six months ended Jun. 30, |   |            | Inception (Sep. 4, 2003) to to
Jun. 30, 2006 | 
|                                            |  | 2006                        |            |   | 2005                      |   |            | 2006                                         |  |   | 2005       |   | 
|Operating expenses:                         |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|General and administrative:                 |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Payroll*                                    |  | $                           | 155,550    |   |                           | $ | 120,817    |                                              |  | $ | 330,057    |   |  | $ | 207,571    |   |  | $ | 1,271,873   |  
|Professional fees*                          |  |                             | 287,715    |   |                           |   | 312,433    |                                              |  |   | 731,001    |   |  |   | 1,020,030  |   |  |   | 2,641,629   |  
|Other general and administrative            |  |                             | 212,936    |   |                           |   | 214,066    |                                              |  |   | 453,395    |   |  |   | 459,237    |   |  |   | 1,509,050   |  
|                                            |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Total general and administrative            |  |                             | 656,201    |   |                           |   | 647,316    |                                              |  |   | 1,514,453  |   |  |   | 1,686,838  |   |  |   | 5,422,552   |  
|Research and development:                   |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Payroll*                                    |  |                             | 222,598    |   |                           |   | 192,131    |                                              |  |   | 448,692    |   |  |   | 271,068    |   |  |   | 1,490,143   |  
|Professional fees*                          |  |                             | 422,100    |   |                           |   | 319,318    |                                              |  |   | 971,942    |   |  |   | 832,087    |   |  |   | 3,112,800   |  
|Preclinical and clinical studies            |  |                             | 1,857,028  |   |                           |   | 608,234    |                                              |  |   | 3,093,311  |   |  |   | 887,456    |   |  |   | 7,258,581   |  
|Other research and development              |  |                             | 174,260    |   |                           |   | 19,807     |                                              |  |   | 249,495    |   |  |   | 34,805     |   |  |   | 586,129     |  
|                                            |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Total research and development              |  |                             | 2,675,986  |   |                           |   | 1,139,490  |                                              |  |   | 4,763,440  |   |  |   | 2,025,416  |   |  |   | 12,447,653  |  
|Loss from operations                        |  |                             | (3,332,187 | ) |                           |   | (1,786,806 | )                                            |  |   | (6,277,893 | ) |  |   | (3,712,254 | ) |  |   | (17,870,205 | )
|Other expenses (income):                    |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Interest expense (income)                   |  |                             | (166,286   | ) |                           |   | (58,769    | )                                            |  |   | (277,810   | ) |  |   | (104,120   | ) |  |   | (408,892    | )
|Warrants issued to related party guarantors |  |                             |           |   |                           |   |           |                                              |  |   |           |   |  |   |           |   |  |   | 17,505      |  
|Liquidated damages expense:                 |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|To related parties                          |  |                             |           |   |                           |   | 94,852     |                                              |  |   |           |   |  |   | 94,852     |   |  |   | 1,102,530   |  
|To other parties                            |  |                             |           |   |                           |   | 181,148    |                                              |  |   |           |   |  |   | 181,148    |   |  |   | 507,900     |  
|                                            |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Total other expenses (income)               |  |                             | (166,286   | ) |                           |   | 217,231    |                                              |  |   | (277,810   | ) |  |   | 171,880    |   |  |   | 1,219,043   |  
|Loss before provision for income taxes      |  |                             | (3,165,901 | ) |                           |   | (2,004,037 | )                                            |  |   | (6,000,083 | ) |  |   | (3,884,134 | ) |  |   | (19,089,248 | )
|Provision for income taxes                  |  |                             |           |   |                           |   |           |                                              |  |   | 2,400      |   |  |   |           |   |  |   | 6,400       |  
|                                            |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Net loss                                    |  | $                           | (3,165,901 | ) |                           | $ | (2,004,037 | )                                            |  | $ | (6,002,483 | ) |  | $ | (3,884,134 | ) |  | $ | (19,095,648 | )
|                                            |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Basic and diluted loss per share:           |  | $                           | (0.13      | ) |                           | $ | (0.16      | )                                            |  | $ | (0.26      | ) |  | $ | (0.35      | ) |  | $ | (2.10       | )
|                                            |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  
|Weighted average common shares outstanding  |  |                             | 23,723,600 |   |                           |   | 12,605,342 |                                              |  |   | 22,899,887 |   |  |   | 11,093,242 |   |  |   | 9,088,064   |  
|                                            |  |                             |            |   |                           |   |            |                                              |  |   |            |   |  |   |            |   |  |   |             |  



|* | Includes stock-based compensation. See Note 7(e)
|- | ------------------------------------------------

See accompanying notes to condensed consolidated financial statements



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MEDIVATION, INC.

(A DEVELOPMENT STAGE COMPANY)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited)



|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|------------------------------------------------------------------------------- |  | ------------------------- | ---------- | - | ----------------------------------------- | - | ----------- | - |  | - | ----------- | -
|                                                                                |  | Six months ended Jun. 30, |            |   | Inception (Sep. 4, 2003) to Jun. 30, 2006 |  
|                                                                                |  | 2006                      |            |   | 2005                                      |   |            
|Cash flows from operating activities:                                           |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Net loss                                                                        |  | $                         | (6,002,483 | ) |                                           | $ | (3,884,134  | ) |  | $ | (19,095,648 | )
|Adjustments to reconcile net loss to net cash used by operating activities:     |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Impairment of intellectual property                                             |  |                           | 68,238     |   |                                           |   |            |   |  |   | 143,238     |  
|Depreciation and amortization                                                   |  |                           | 4,048      |   |                                           |   | 4,137       |   |  |   | 18,814      |  
|Stock-based compensation                                                        |  |                           | 704,006    |   |                                           |   | 658,097     |   |  |   | 1,926,509   |  
|Liquidated damages accrued:                                                     |  |                           |            |   |                                           |   |             |   |  |   |             |  
|To related parties                                                              |  |                           |           |   |                                           |   | 94,852      |   |  |   | 1,102,530   |  
|To other parties                                                                |  |                           |           |   |                                           |   | 181,148     |   |  |   | 507,900     |  
|Liquidated damages paid:                                                        |  |                           |            |   |                                           |   |             |   |  |   |             |  
|To related parties                                                              |  |                           | (16,120    | ) |                                           |   |            |   |  |   | (1,102,530  | )
|To other parties                                                                |  |                           | (256,379   | ) |                                           |   |            |   |  |   | (507,900    | )
|Warrants issued to related party guarantors                                     |  |                           |           |   |                                           |   |            |   |  |   | 17,505      |  
|Changes in operating assets and liabilities:                                    |  |                           |            |   |                                           |   |             |   |  |   |            |  
|Prepaid expenses and other current assets                                       |  |                           | (70,727    | ) |                                           |   | 74,117      |   |  |   | (359,372    | )
|Other assets                                                                    |  |                           | (36,901    | ) |                                           |   |            |   |  |   | (36,901     | )
|Accounts payable                                                                |  |                           | 17,652     |   |                                           |   | 86,971      |   |  |   | 1,194,590   |  
|Other current liabilities                                                       |  |                           | (6,825     | ) |                                           |   | 37,902      |   |  |   | 2,726       |  
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Net cash provided by (used in) operating activities                             |  |                           | (5,595,491 | ) |                                           |   | (2,746,910  | ) |  |   | (16,188,539 | )
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Cash flows from investing activities:                                           |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Medivation cash balances at closing of December 2004 merger                     |  |                           |           |   |                                           |   |            |   |  |   | 1,928,839   |  
|Purchase of investment securities                                               |  |                           | (8,588,040 | ) |                                           |   | (11,874,451 | ) |  |   | (28,712,844 | )
|Maturities of investment securities                                             |  |                           | 5,576,207  |   |                                           |   | 6,000,000   |   |  |   | 17,576,207  |  
|Accrued interest on investment securities                                       |  |                           | (166,378   | ) |                                           |   | (84,089     | ) |  |   | (300,498    | )
|Interest received on investment securities                                      |  |                           | 47,832     |   |                                           |   |            |   |  |   | 47,832      |  
|Purchase of property and equipment                                              |  |                           |           |   |                                           |   |            |   |  |   | (8,763      | )
|Purchase of intellectual property                                               |  |                           |           |   |                                           |   |            |   |  |   | (225,000    | )
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Net cash provided by (used in) investing activities                             |  |                           | (3,130,379 | ) |                                           |   | (5,958,540  | ) |  |   | (9,694,227  | )
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Cash flows from financing activities:                                           |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Issuance of Series B preferred stock                                            |  |                           |           |   |                                           |   |            |   |  |   | 1,800       |  
|Issuance of convertible notes:                                                  |  |                           |            |   |                                           |   |             |   |  |   |             |  
|To related party                                                                |  |                           |           |   |                                           |   |            |   |  |   | 1,250,000   |  
|To other party                                                                  |  |                           |           |   |                                           |   |            |   |  |   | 600,000     |  
|Principal repayment on notes held by related party                              |  |                           |           |   |                                           |   |            |   |  |   | (595,861    | )
|Issuance of common stock for cash                                               |  |                           | 14,250,000 |   |                                           |   |            |   |  |   | 35,403,195  |  
|Offering costs payable in cash                                                  |  |                           | (1,119,753 | ) |                                           |   |            |   |  |   | (1,808,980  | )
|Class B warrant exercises                                                       |  |                           |           |   |                                           |   |            |   |  |   | 20,563      |  
|Stock option exercises                                                          |  |                           |           |   |                                           |   |            |   |  |   | 360         |  
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Net cash provided by (used in) financing activities                             |  |                           | 13,130,247 |   |                                           |   |            |   |  |   | 34,871,077  |  
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Net increase (decrease) in cash                                                 |  |                           | 4,404,377  |   |                                           |   | (8,705,450  | ) |  |   | 8,988,311   |  
|Cash and cash equivalents at beginning of period                                |  |                           | 4,583,934  |   |                                           |   | 10,671,707  |   |  |   |            |  
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Cash and cash equivalents at end of period                                      |  | $                         | 8,988,311  |   |                                           | $ | 1,966,257   |   |  | $ | 8,988,311   |  
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Cash paid for interest to related party                                         |  | $                         |           |   |                                           | $ |            |   |  | $ | 26,859      |  
|Supplemental schedule of non-cash investing and financing activities:           |  |                           |            |   |                                           |   |             |   |  |   |             |  
|Shares issued for conversion of convertible notes (including accrued interest): |  |                           |            |   |                                           |   |             |   |  |   |             |  
|To related party                                                                |  | $                         |           |   |                                           | $ |            |   |  | $ | 688,955     |  
|To other party                                                                  |  |                           |           |   |                                           |   |            |   |  |   | 610,776     |  
|Shares issued to purchase intellectual property                                 |  |                           |           |   |                                           |   |            |   |  |   | 900         |  
|Shares issued for placement agent services in the December 2004 financing       |  |                           |           |   |                                           |   |            |   |  |   | 969,834     |  
|Warrants issued for placement agent services in the December 2004 financing     |  |                           |           |   |                                           |   |            |   |  |   | 633,149     |  
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  
|                                                                                |  | $                         |           |   |                                           | $ |            |   |  | $ | 2,903,614   |  
|                                                                                |  |                           |            |   |                                           |   |             |   |  |   |             |  

See accompanying notes to condensed consolidated financial statements



---

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

June 30, 2006

(Unaudited)



|1. | DESCRIPTION OF BUSINESS AND CORPORATE STRUCTURE
|-- | -----------------------------------------------

Medivation, Inc. (Medivation or the Company), together with its operating subsidiaries, is a life sciences company based in San Francisco, California. The Companys corporate strategy is to acquire promising biomedical technologies it
believes can enter clinical development within 12  18 months after acquisition, and to develop those technologies quickly and cost-effectively through human first proof-of-efficacy studies (generally the end of Phase 2 clinical trials).
Depending on the indication and its commercial potential, Medivation will either seek to sell or partner successful programs with larger pharmaceutical, biotechnology and medical device companies for late-stage clinical studies and
commercialization, or pursue those activities internally. The Company intends to build and maintain a portfolio of four to six development programs at all times. Medivations current portfolio consists of small molecule drugs in development to
treat three large, unmet medical needs  Alzheimers disease, Huntingtons disease and hormone-refractory prostate cancer. The Company also is evaluating other biomedical technologies for potential acquisition.

The Company presently has two operating subsidiaries  Medivation Neurology, Inc. (MNI), which was incorporated in Delaware on September 4,
2003 to acquire and develop the Dimebon technology for Alzheimers disease and Huntingtons disease, and Medivation Prostate Therapeutics, Inc. (MPT), which was incorporated in Delaware on June 30, 2005 to acquire and develop the
MDV300 Series technology for hormone-refractory prostate cancer.



|2. | BASIS OF PRESENTATION
|-- | ---------------------

The accompanying unaudited
condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles for interim financial information and with the instructions to Form 10-QSB and Item 310(b) of Regulation S-B. Accordingly
they do not include all of the information and footnotes necessary for a fair presentation of financial condition, results of operations and cash flows in conformity with generally accepted accounting principles. In the opinion of management of
Medivation, the interim condensed consolidated financial statements included herewith contain all adjustments (consisting of normal recurring accruals and adjustments) necessary for their fair presentation. The unaudited interim condensed
consolidated financial statements should be read in conjunction with the Companys Annual Report on Form 10-KSB, as amended, which contains the audited financial statements and notes thereto, together with the Managements Discussion and
Analysis, for the year ended December 31, 2005. The interim results for the period ended June 30, 2006 are not necessarily indicative of results for the full fiscal year.



|3. | THE MERGER
|-- | ----------

(a) Description of the Merger

MNI became a wholly-owned subsidiary of the Company pursuant to a merger on December 17, 2004 (the Merger). Pursuant to the Merger,
Medivations cash balances of approximately $1,929,000 became available to fund the ongoing operations of the combined Company. Following the Merger, the business conducted by the Company is the business conducted by MNI prior to the Merger.

(b) Accounting Treatment of the Merger; Financial Statement Presentation

The Merger was accounted for as a reverse merger under generally accepted accounting principles. Therefore, the consolidated financial statements of the
Company for periods prior to December 17, 2004 reflect only the operations of MNI.



|4. | SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
|-- | ------------------------------------------

(a) Basis of
Consolidation

The consolidated financial statements incorporate the accounts of Medivation and its operating subsidiaries MNI and MPT.
All significant inter-company transactions have been eliminated in consolidation.

(b) Development Stage Company

For the period from inception (September 4, 2003) to date, the Company has been a development stage enterprise, and accordingly, the Companys
operations have been directed primarily toward developing its proprietary technologies. The Company has experienced net losses since its inception and had an accumulated deficit of $19,095,648 (unaudited) at June 30, 2006. Such losses and
accumulated deficit resulted from the Companys absence of revenue and significant costs



---

incurred in the development of the Companys proprietary technologies. The Company expects to incur substantial and increasing losses as it expands its
technology portfolio and engages in further research and development activities, particularly the conduct of preclinical and clinical trials.

(c)
Estimates

The preparation of financial statements in conformity with generally accepted accounting principles requires that management
make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the
reporting period. Estimates and assumptions principally relate to services performed by third parties but not yet invoiced, estimates of the fair value and forfeiture rates of stock options issued to employees and consultants and estimates of the
probability and potential magnitude of contingent liabilities. Actual results could differ from those estimates.

(d) Cash Equivalents

The Company considers all highly liquid investments with a remaining maturity of three months or less at the time of acquisition to be cash
equivalents.

(e) Short-Term Investments

The Company considers all highly liquid investments with a remaining maturity of more than three months but no longer than twelve months at the time of acquisition to be short-term investments.

(f) Property and Equipment

Property and equipment
purchases are recorded at cost. Repairs and maintenance costs are expensed in the period incurred. Items of property and equipment with costs greater than $5,000 are capitalized and depreciated on a straight-line basis over the estimated useful
lives of the assets as follows:



|                                    |  |                                                 
|----------------------------------- |  | ------------------------------------------------
|Description                         |  | Estimated Useful Life                           
|Office equipment and furniture      |  | 3 years                                         
|Laboratory equipment                |  | 5 years                                         
|Leasehold improvements and fixtures |  | Lesser of estimated useful life or life of lease

(g) Intellectual Property

The costs of acquiring intellectual property rights to be used in the research and development process, including licensing fees and milestone payments, are charged to research and development expense as incurred in
situations where the Company has not identified an alternative future use for the acquired rights, and are capitalized in situations where it has identified an alternative future use. Capitalized costs are amortized over the life of the applicable
intellectual property right. Legal and other costs of prosecuting and maintaining intellectual property rights are expensed as incurred.

(h) Impairment
or Disposal of Long-lived Assets

The Company evaluates its long-lived assets, primarily its intellectual property, for impairment
whenever events or changes in circumstances indicate that the carrying amount of such assets or intangibles may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future
undiscounted net cash flows expected to be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured by the amount by which the carrying amount of the assets exceeds the fair value of the
assets. Assets to be disposed of are reported at the lower of the carrying amount or fair value less cost to sell. The impairment amount is included in research and development expenses.

(i) Research and Development

Research and development costs are charged to expense when incurred.



---

(j) Stock-Based Compensation; Adoption of SFAS No. 123R

Effective January 1, 2005, the Company adopted SFAS No. 123R, Share-Based Payment, which requires the Company to record as an expense in
its financial statements the fair value of all stock-based compensation awards.

(k) Loss per Common Share

The Company calculates loss per share in accordance with SFAS No. 128, Earnings per Share. Basic loss per share is computed by dividing
the loss available to common shareholders by the weighted-average number of common shares outstanding. Diluted loss per share is computed similarly to basic loss per share except that the denominator is increased to include the number of additional
common shares that would have been outstanding if the potential common shares had been issued and if the additional common shares were dilutive.

The following potential common shares outstanding at June 30, 2006 have been excluded from the computation of diluted net loss per share for the three- and six-month periods ended June 30, 2006 and 2005, and for the period from
inception (September 4, 2003) to June 30, 2006, because they are antidilutive:



|         |  |          
|-------- |  | ---------
|Warrants |  | 500,104  
|Options  |  | 1,549,250
|         |  |          
|TOTAL    |  | 2,049,354
|         |  |          

(l) Income Taxes

The Company accounts for income taxes in accordance with SFAS No. 109, Accounting for Income Taxes, which requires the recognition of deferred tax assets and liabilities for the expected future tax
consequences of events that have been included in the financial statements or tax returns. Under this method, deferred income taxes are recognized for the tax consequences in future years of differences between the tax bases of assets and
liabilities and their financial reporting amounts at each year-end based on enacted tax laws and statutory tax rates applicable to the period in which the differences are expected to affect taxable income. Because of its current net loss position,
the Company has provided a valuation allowance in full on its net deferred tax assets in accordance with SFAS No. 109 and in light of the uncertainty regarding ultimate realization of the net deferred tax assets. Provisions for income taxes consist
solely of the California minimum state corporate income tax, and totaled $0 and $2,400, respectively, for the three- and six-month periods ended June 30, 2006, $0 and $0, respectively, for the three- and six-month periods ended June 30, 2005, and
$6,400 for the period from inception (September 4, 2003) to June 30, 2006.



|5. | INVESTMENT SECURITIES HELD TO MATURITY
|-- | --------------------------------------

The Company
accounts for its investment securities in accordance with SFAS No. 115, Accounting for Certain Investments in Debt and Equity Securities. At June 30, 2006, investment securities consisted of Federal Home Loan Bank discount
notes and Federal National Mortgage Association discount notes maturing between August and December 2006. At June 30, 2006, one such investment security, with an amortized cost basis of $5,967,453 (unaudited), is included in cash and cash
equivalents, and the remaining investment securities, with an aggregate amortized cost basis of $11,389,303 (unaudited), are included in short-term investments. The Company has accounted for its investment securities as held-to-maturity since it has
the positive intent and ability to hold them to maturity. At June 30, 2006, the estimated fair value of these securities was $17,301,381 (unaudited), resulting in a gross unrealized holding loss of $55,375 (unaudited).



|6. | INTELLECTUAL PROPERTY
|-- | ---------------------

At June 30, 2006,
intellectual property consisted of patents and patent applications acquired from third parties. This intellectual property is being amortized over periods ranging from 156 months to 248 months. Amortization expense on the Companys intellectual
property was $1,103 (unaudited) and $2,069 (unaudited), respectively, for the three months ended June 30, 2006 and 2005, $3,172 (unaudited) and $4,137 (unaudited), respectively, for the six months ended June 30, 2006 and 2005, and $17,718
(unaudited) for the period from inception (September 4, 2003) to June 30, 2006. In the quarter ended June 30, 2006, the Company wrote off $68,238 (unaudited) of its historical patent acquisition costs to reflect managements decision
to stop work on a patent application that is unrelated to the Companys ongoing development programs.



|7. | STOCKHOLDERS EQUITY
|-- | --------------------

(a) Common Stock

On May 17, 2006, the Company issued 3,000,000 (unaudited) shares of its Common Stock in a registered direct offering (the 2006 Offering), raising
gross proceeds of $14,250,000 (unaudited). Placement agent, legal, accounting, printing and other costs related to the 2006 Offering, in the aggregate amount of $1,119,753 (unaudited), were charged to additional paid-in capital in the quarter ended
June 30, 2006.

On December 15, 2005, the Company issued 5,635,000 shares of its Common Stock in an underwritten public offering
(the 2005 Offering), raising proceeds (net of underwriting discount) of $10,452,925. Legal, accounting, printing, travel and other costs related to the 2005 Offering, in the aggregate amount of $689,227, were charged to additional paid-in capital in
the quarter ended December 31, 2005.

In the year ended December 31, 2005, the Company issued an aggregate of 203,300 shares of
Common Stock upon the exercise of outstanding Class B Warrants, for an aggregate exercise price of $25,413.



---

On December 17, 2004, the Company issued 7,741,935 shares of its Common Stock in a private placement
to accredited investors (the 2004 Offering), 6,903,399 of which were sold for cash, generating $10,700,270 in gross proceeds. The remaining 838,536 shares were issued in exchange for cancellation of outstanding bridge notes of MNI, in the aggregate
amount of $1,299,731, which were assumed by the Company in the Merger. Medivation also issued an aggregate of 625,699 shares of its Common Stock to two investment banking firms as partial compensation for placement agent services provided in
connection with the 2004 Offering. The cost of these shares, in the aggregate amount of $969,834, was offset against additional paid-in capital in the year ended December 31, 2004.

(b) Preferred Stock

The Company is authorized to issue 1,000,000 shares of preferred stock with such
designations, voting, and other rights and preferences as may be determined from time to time by the Board of Directors. The Company has outstanding 110 shares of Series A Redeemable Preferred Stock. The Series A Redeemable Preferred Stock is
non-voting, non-convertible and non-dividend bearing. The Series A Redeemable Preferred Stock is redeemable at any time, at the option of the holders thereof, for an aggregate redemption price of $11,000. Because of this redemption feature, the
Series A Redeemable Preferred Stock is reflected as a current liability on the consolidated financial statements. No other preferred stock of the Company is outstanding.

(c) Warrants Issued to Related Parties

On November 16, 2004, MNI issued warrants to purchase
its equity securities to two of its officers in return for their agreement to guarantee certain corporate obligations. These warrants were assumed by Medivation in the Merger. The fair value of these warrants in the amount of $17,505 (based on the
Black-Scholes option pricing model and the following assumptions: stock price of $1.55; historical volatility of 90%; risk free rate of approximately 4.5%; dividend yield of 0%; and warrant life of 10 years) was recorded as an expense in the
statement of operations for the year ended December 31, 2004.

(d) Other Warrants

On December 17, 2004, Medivation issued warrants to an investment banking firm in return for placement agent services provided in connection with the
2004 Offering. At December 17, 2004, the fair value of these warrants was $633,149 (based on the Black-Scholes option pricing model and the following assumptions: stock price of $1.55; historical volatility of 90%; risk free rate of 3.59%;
dividend yield of 0%; and warrant life of 5.0 years).

(e) Medivation Equity Incentive Plan

The Medivation 2004 Equity Incentive Plan (the Medivation Equity Incentive Plan), which is stockholder-approved, provides for the issuance of options and
other equity-based awards, including restricted stock and stock appreciation rights, covering up to 3,000,000 shares of Medivations Common Stock. Shares issued upon exercise of equity-based awards are new shares that have been reserved for
issuance under the plan. The Medivation Equity Incentive Plan is administered by our board of directors, or a committee appointed by the Board, which determines recipients and types of awards to be granted, including the number of shares subject to
the awards, the exercise price and the vesting schedule. The term of stock options granted under the Medivation Equity Incentive Plan cannot exceed ten years. Options generally have an exercise price equal to the fair market value of our Common
Stock on the grant date, and generally vest over a period of four years. The options may contain an early exercise feature, pursuant to which the optionee may exercise the option before it has vested. However, so long as an option remains unvested,
all shares purchased upon early exercise remain subject to repurchase by Medivation at the option exercise price if the optionees service with Medivation terminates. For purposes of the following disclosures, early exercise options are not
considered to have been exercised, or to be exercisable, until this repurchase right has lapsed. In addition, all outstanding awards under the Medivation Equity Incentive Plan will accelerate and become immediately exercisable upon a change of
control of Medivation, as defined in the Medivation Equity Incentive Plan.

The Company recorded stock-based compensation expense of
$291,243 (unaudited) and $161,987 (unaudited), respectively, in the three months ended June 30, 2006 and 2005, $704,006 (unaudited) and $658,097 (unaudited), respectively, in the six months ended June 30, 2006 and 2005, and $1,926,509
(unaudited) in the period from inception (September 4, 2003) to June 30, 2006 with respect to awards under the Medivation Equity Incentive Plan.



---

Pursuant to Staff Accounting Bulletin 107, in the statement of operations stock-based compensation
expense is included in payroll expense (in the case of options granted to employees and non-employee directors) and professional fees (in the case of options granted to consultants). Cash-based and stock-based payroll expense and professional fees
for the periods presented are as follows (unaudited):



|                        |  |                             |         |                           |   |                                         |  |      |         |  |   |           |  |   |          
|----------------------- |  | --------------------------- | ------- | ------------------------- | - | --------------------------------------- |  | ---- | ------- |  | - | --------- |  | - | ---------
|                        |  | Three months ended Jun. 30, |         | Six months ended Jun. 30, |   | Inception(Sep. 4, 2003) toJun. 30, 2006
|                        |  | 2006                        |         | 2005                      |   | 2006                                    |  | 2005 |        
|Payroll expense (G&A)   |  |                             |         |                           |   |                                         |  |      |         |  |   |           |  |   |          
|Cash-based              |  | $                           | 126,582 |                           | $ | 106,164                                 |  | $    | 255,325 |  | $ | 192,919   |  | $ | 1,086,357
|Stock-based             |  |                             | 28,968  |                           |   | 14,653                                  |  |      | 74,732  |  |   | 14,652    |  |   | 185,516  
|Total                   |  | $                           | 155,550 |                           | $ | 120,817                                 |  | $    | 330,057 |  | $ | 207,571   |  | $ | 1,271,873
|Professional fees (G&A) |  |                             |         |                           |   |                                         |  |      |         |  |   |           |  |   |          
|Cash-based              |  | $                           | 131,447 |                           | $ | 254,965                                 |  | $    | 423,173 |  | $ | 712,637   |  | $ | 1,773,123
|Stock-based             |  |                             | 156,268 |                           |   | 57,468                                  |  |      | 307,828 |  |   | 307,393   |  |   | 868,506  
|Total                   |  | $                           | 287,715 |                           | $ | 312,433                                 |  | $    | 731,001 |  | $ | 1,020,030 |  | $ | 2,641,629
|Payroll expense (R&D)   |  |                             |         |                           |   |                                         |  |      |         |  |   |           |  |   |          
|Cash-based              |  | $                           | 144,811 |                           | $ | 121,076                                 |  | $    | 291,054 |  | $ | 188,171   |  | $ | 1,095,723
|Stock-based             |  |                             | 77,787  |                           |   | 71,055                                  |  |      | 157,638 |  |   | 82,897    |  |   | 394,420  
|Total                   |  | $                           | 222,598 |                           | $ | 192,131                                 |  | $    | 448,692 |  | $ | 271,068   |  | $ | 1,490,143
|Professional fees (R&D) |  |                             |         |                           |   |                                         |  |      |         |  |   |           |  |   |          
|Cash-based              |  | $                           | 393,880 |                           | $ | 300,507                                 |  | $    | 808,134 |  | $ | 578,932   |  | $ | 2,634,733
|Stock-based             |  |                             | 28,220  |                           |   | 18,811                                  |  |      | 163,808 |  |   | 253,155   |  |   | 478,067  
|Total                   |  | $                           | 422,100 |                           | $ | 319,318                                 |  | $    | 971,942 |  | $ | 832,087   |  | $ | 3,112,800

Options granted to employees and non-employee directors are recorded as deferred compensation at
their grant-date fair value, and expensed over the remaining vesting periods of the options. At June 30, 2006, deferred compensation not yet recognized as expense totaled $1,384,617 (unaudited). Options granted to consultants are valued at
their respective measurement dates, and recognized as expense based on the portion of the total consulting services provided during the applicable period. As further consulting services are provided in future periods, Medivation will revalue the
associated options and recognize additional expense based on their then-current fair values.

Medivation estimates the fair value of each
option award using the Black-Scholes option valuation model. Estimated volatility is based on the historical volatility of Medivations Common Stock since January 1, 2005, the beginning of the first quarter following the acquisition of
Medivations current business operations on December 17, 2004. Estimated dividend yield is 0%. Given Medivations limited options history to date, in the second quarter of 2006 management adopted the simplified method for estimating
the expected term of plain vanilla options provided for in Staff Accounting Bulletin 107. Pursuant to that method, the expected term of options granted to employees and non-employee directors is estimated to be six years. In the
second quarter of 2006 management also revised to four years the estimated expected term of options granted to consultants. As more historical data regarding optionee exercise practices become available, management will review and revise its
expected term assumptions as appropriate. The risk-free rate is estimated to equal U.S. Treasury security rates for the applicable terms.

At June 30, 2006, the total outstanding, and the total exercisable, options under the Medivation Equity Incentive Plan were as follows (unaudited):



|                          |  |                                  |  |                               |      |                                          |           |                         |   |          
|------------------------- |  | -------------------------------- |  | ----------------------------- | ---- | ---------------------------------------- | --------- | ----------------------- | - | ---------
|                          |  | NumberOutstandingatJun. 30, 2006 |  | Weighted-AverageExercisePrice |      | Weighted-AverageRemainingContractualTerm |           | AggregateIntrinsicValue
|Total outstanding options |  | 1,549,250                        |  | $                             | 2.60 |                                          | 8.7 years |                         | $ | 3,957,514
|Total exercisable options |  | 539,668                          |  | $                             | 2.32 |                                          | 8.6 years |                         | $ | 1,526,539



|8. | THIRD PARTY EQUITY INTERESTS IN OPERATING SUBSIDIARIES
|-- | ------------------------------------------------------

(a)
Medivation Neurology, Inc.

At June 30, 2006, Medivation owned all of the issued and outstanding stock of its operating subsidiary
MNI, and there were no outstanding options, warrants or any other third party rights to acquire any MNI stock.



---

(b) Medivation Prostate Therapeutics, Inc.

At June 30, 2006, Medivation owned all 3,610,607 (unaudited) shares of the issued and outstanding stock of its operating subsidiary MPT, and is
entitled to receive one additional share for each dollar that Medivation subsequently invests, directly or indirectly, in MPT. MPT has reserved an aggregate of 3,000,000 shares of its Common Stock for issuance upon the exercise of awards granted
under the Medivation Prostate Therapeutics, Inc. Equity Incentive Plan (the MPT Equity Incentive Plan). At June 30, 2006, one option was outstanding under the MPT Equity Incentive Plan. This option, which was issued to the licensor of
MPTs hormone-refractory prostate cancer technology, is exercisable without cash payment for 150,000 (unaudited) shares of MPT Common Stock, but vests and becomes exercisable only upon the occurrence of specified MPT liquidity events including
a sale of MPT, a public offering of MPTs Common Stock, a corporate partnership involving MPT, or receipt of regulatory approval to market any MPT product. In accordance with Emerging Issues Task Force (EITF) Issue No. 96-18,
Accounting for Equity Instruments That Are Issued to Other Than Employees for Acquiring, or in Conjunction with Selling, Goods or Services, no expense will be recognized with respect to this option unless and until such a liquidity event
occurs.



|9. | LIQUIDATED DAMAGES TO RELATED AND OTHER PARTIES
|-- | -----------------------------------------------

In
the year ended December 31, 2005, the Company recorded aggregate liquidated damages of $1,610,430 to investors in the 2004 Offering as a result of the inability to register by an agreed-upon date certain shares sold in that offering. Of this
amount, $1,102,530 (unaudited) pertains to related party investors, and $507,900 (unaudited) pertains to other investors. The formulas used to calculate the amounts payable to related party investors and to other investors were identical. Medivation
paid $1,337,931 (unaudited) of this amount in the year ended December 31, 2005, and the remaining $272,499 (unaudited) in the three months ended March 31, 2006.



|10. | CONVERTIBLE NOTE TRANSACTIONS WITH RELATED PARTY
|--- | ------------------------------------------------

In October 2003 and April 2004, our subsidiary MNI received bridge loans from a related party in the aggregate principal amount of $1,250,000. Principal plus accrued interest on these loans in the amount of $688,955 was converted
into Medivation Common Stock in the 2004 Offering. The remaining outstanding principal plus accrued interest of $622,720 was repaid in December 2004.



|11. | COMMITMENTS AND CONTINGENCIES
|--- | -----------------------------

The Company leases a
single office facility in San Francisco, California under a non-cancelable operating lease that expires in April 2011. Total future lease payments under this lease at June 30, 2006 were $738,741 (unaudited), plus annual operating cost
escalations.



|Item 2. | Managements Discussion and Analysis or Plan of Operation.
|------- | ----------------------------------------------------------

The following discussion should be read in conjunction with the attached unaudited condensed consolidated financial statements and notes thereto, and with our audited consolidated financial statements and notes
thereto for the fiscal year ended December 31, 2005, found in our Annual Report on Form 10-KSB, as amended.

The following
Managements Discussion and Analysis or Plan of Operation contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. We
intend that these forward-looking statements be subject to the safe harbors created by those provisions. Forward-looking statements are generally written in the future tense and/or are preceded by words such as may, should,
forecast, could, expect, suggest, believe, anticipate, intend, plan, or other similar words. The forward-looking statements contained in this Quarterly
Report involve a number of risks and uncertainties, many of which are outside of our control. Factors that could cause actual results to differ materially from projected results include, but are not limited to, the Risk Factors included in our
Annual Report on Form 10-KSB, as amended, for the fiscal year ended December 31, 2005. Readers are expressly advised to review and consider those Risk Factors, which include risks associated with (1) our ability to successfully conduct
clinical and preclinical trials for our product candidates, (2) our ability to raise additional capital on favorable terms, (3) our ability to identify and obtain additional product candidates, and (4) our ability to execute our
business plan on time and on budget. Although we believe that the assumptions underlying the forward-looking statements contained in this Quarterly Report are reasonable, any of the assumptions could be inaccurate, and therefore there can be no
assurance that such statements will be accurate. In light of the significant uncertainties inherent in the forward-looking



---

statements included herein, the inclusion of such information should not be regarded as a representation by us or any other person that the results or
conditions described in such statements or our objectives and plans will be achieved. Furthermore, past performance in operations and share price is not necessarily indicative of future performance. We disclaim any intention or obligation to update
or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Our Business Strategy

Our business strategy is to acquire promising biomedical technologies  including pharmaceuticals, biologics and medical
devices  and to develop them quickly and cost-effectively through human first proof-of-efficacy studies (generally the end of Phase 2 clinical trials). We seek to establish and maintain a portfolio of between four and six active
development programs at any given time. We focus on technologies that have strong intellectual property positions, address large unmet medical needs, and have the potential to enter clinical development within 12 to 18 months after acquisition.
Based on this focus, we generally will not engage in discovery research. To minimize fixed costs and maximize flexibility, we have developed a business model which efficiently uses experienced outside consultants, who in essence become part of our
management team for specific projects. Depending on the indication and commercial potential of any technologies we successfully develop through completion of Phase 2 clinical studies, we will either sell or partner these programs with larger
pharmaceutical, biotechnology or medical device companies for later-stage development and commercialization, or pursue those activities internally. Upon completion of any such sale or partnership transaction, and depending on our then-current
capital needs, we will consider returning transaction proceeds to our investors through special dividends or stock repurchases.

We believe
that our business strategy maximizes what we perceive to be our competitive advantages, including:



| |  |  | our ability to identify and acquire biomedical technologies with favorable risk/reward ratios based on our experience and technical expertise;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our credibility and relationships with the academic community, a primary source of deal flow for the biomedical technologies we target;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to develop biomedical technologies more quickly and cost-effectively than larger, less flexible companies; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------



| |  |  | our managements track record of successfully executing this business strategy, from technology acquisition through receipt of marketing approval, commercial launch, and exit
by sale to a corporate partner, at a prior company.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Our Current Portfolio

Our current portfolio consists of small molecule drugs in development to treat three large, unmet medical needs  Alzheimers disease,
Huntingtons disease and hormone-refractory prostate cancer.

Alzheimers Disease Program. We are conducting a
randomized, double-blind, placebo-controlled Phase 2 study of Dimebon in Alzheimers disease patients in Russia. We completed enrollment of 183 patients in this study in February 2006, and expect to report study results in the third
quarter of 2006.

Huntingtons Disease Program. In January 2006, we filed an investigational new drug application
with the U.S. Food and Drug Administration, or FDA, to begin a Phase 1-2a clinical study of Dimebon in Huntingtons disease patients. Our proposed study design has two parts. Part A is an open-label dose escalation phase in which
patients will be treated with increasing doses of Dimebon to determine safety, tolerability, pharmacokinetics, and the recommended doses for Part B of the study. Part B is a randomized, double-blind, placebo-controlled phase in which
approximately 75 patients will be treated for a period of 90 days to further evaluate the safety and preliminary efficacy of Dimebon as a treatment for Huntingtons disease. In May 2006, we received a letter from the FDA confirming
information it initially communicated to us in a February 2006 telephone call that additional rat toxicology data are required before our proposed clinical trial can begin. The FDA expressed the concern that the dose levels of Dimebon used in
one of our rat toxicology studies did not result in sufficient toxicity to define a maximum tolerated dose. This information might provide additional guidance to physicians regarding the potential toxicities of Dimebon in humans. To address the
FDAs concern, in March 2006 we initiated additional rat toxicology studies to evaluate Dimebon at higher doses than those used in the prior study. We have completed the 7-day and 28-day rat toxicology studies which support performing Part
A of our proposed Phase 1-2a clinical study. We expect to submit the results of those studies to the FDA in August 2006, and believe that the results address the FDAs concern. We expect to begin Part A of our proposed Phase 1-2a clinical
study in the third quarter of 2006, and to complete Part A in the first half of 2007. The 90-day rat toxicology study required to support Part B of our proposed Phase 1-2a clinical study is currently underway, and we expect to complete it in
the fourth quarter of 2006. We expect to begin Part B of our proposed Phase 1-2a clinical study in the first half of 2007, and to complete Part B  which we expect to include an efficacy endpoint  in the second half of
2007.



---

Hormone-Refractory Prostate Cancer Program. Our MDV300 Series compounds are in development
for the treatment of hormone-refractory prostate cancer. In the first quarter of 2007 we expect to file an investigational new drug application with the FDA to begin a clinical study of our lead compound, MDV3100, in hormone-refractory prostate
cancer patients. Our proposed study design is an open-label dose-escalation trial with each patient continuing on MDV3100 for at least three months in the absence of a significant safety issue or disease progression. In addition, 20 subjects will be
enrolled and treated with the maximum-tolerated dose for at least 90 days to further evaluate the safety, tolerability and preliminary efficacy of MDV3100 as a treatment for hormone-refractory prostate cancer. Patients serum levels of
prostate-specific antigen, a frequently-used surrogate marker of prostate cancer progression, will be measured regularly in the study. Patients will be given the option in certain circumstances to continue treatment for longer periods of time. We
have had communications with the FDA to address the proposed clinical trial design and the preclinical studies to be included in our investigational new drug application. We expect to begin this clinical study in the first half of 2007, and to
report efficacy data from at least a subset of the hormone-refractory prostate cancer patients in this study in the second half of 2007.

As used in this report, a Phase 1-2a clinical study is one conducted in patients with the applicable disease and that includes at least one efficacy endpoint. Because both Huntingtons disease and hormone-refractory
prostate cancer are life-threatening diseases with inadequate current treatment options, we believe that the initial clinical trials we conduct in those indications will be Phase 1-2a trials.

Our Business Plan Through June 30, 2007

Our
business plan through June 30, 2007 (Business Plan) consists of the following development activities:

Dimebon Alzheimers
Disease Program: (a) complete our randomized, double-blind, placebo-controlled Phase 2 efficacy study of Dimebon in Alzheimers disease patients in Russia in the third quarter of 2006; and (b) if the results are positive,
initiate further development, either internally or through sale or partnership of the program.

Dimebon Huntingtons Disease
Program:(a) begin Part A of our planned Phase 1-2a clinical study in 2006; (b) complete in the fourth quarter of 2006 the 90-day rat toxicology study required to begin Part B of our planned Phase 1-2a clinical
study; and (c) begin Part B of our clinical study in the first half of 2007.

MDV300 Series Prostate Cancer
Program: (a) manufacture our lead development candidate MDV3100 for use in IND-enabling preclinical studies and our planned clinical study; (b) complete the IND-enabling preclinical studies; (c) file in the first quarter of
2007 an investigational new drug application seeking FDA approval to begin our planned clinical study; and (d) begin that study in the first half of 2007.

New Technologies: identify, evaluate and, subject to availability of sufficient funds, acquire one new development program.

Based on presently available information, our management believes that achievement of the above development milestones relating to our existing product candidates on or before June 30, 2007 is a reasonably
achievable goal. However, the development of biomedical product candidates is subject to high levels of risk, including risks presented by subsequent developments that are unforeseen or unforeseeable, as well as risks that are entirely outside of
our control, including the risk of unfavorable results in the preclinical studies required to begin clinical trials, and the risk that the FDA and/or comparable foreign regulatory agencies will deny, or impose burdensome conditions on, our requests
to begin clinical trials. We thus cannot guarantee that we will be able to complete any of these milestone events, or that any of them that we do achieve will be on time or on budget.

Liquidity and Capital Resources

We have incurred aggregate net losses of $19,095,648 (unaudited)
through June 30, 2006, and we expect to incur substantial and increasing additional losses in the future as we expand our portfolio and continue our research and development activities, particularly the conduct of preclinical and clinical
studies. We have not generated any revenue from operations to date, and do not expect to generate operating revenue for several years, if ever. All of our operations to date have been funded through the sale of our debt and equity securities, and we
expect this to continue to be the case for the foreseeable future.

As of June 30, 2006, we had cash and cash equivalents and other
current assets of $20,741,836 (unaudited), accounts payable and other current liabilities of $1,204,749 (unaudited), and no long-term debt. We expect that this amount will be sufficient to fund the presently budgeted costs of executing our Business
Plan, excluding acquisition costs of any new technology we may wish to acquire. However, we caution you that this is a forward-looking statement and is subject to significant risk and uncertainty.



---

The process of conducting studies required to obtain regulatory approval to sell our product candidates
is lengthy and very expensive, and cannot be completed for any of our existing product candidates by June 30, 2007, nor can we control whether we will be able to sell or partner any of our programs by that date. We therefore expect we will need
to raise additional financing to fund development activities beyond the scope of our Business Plan, including funding to continue development of our Dimebon/Alzheimers disease program beyond completion of the ongoing Phase 2 clinical
study, and potentially also to complete one or both of our planned Phase 1-2a clinical studies of Dimebon in Huntingtons disease and of MDV3100 in hormone-refractory prostate cancer. In addition, should we identify one or more new product
candidates that we wish to acquire, we may need to raise additional financing sooner than June 30, 2007 to finance the acquisition and subsequent development of any such new product candidate(s). We also may need to raise additional financing
before June 30, 2007 should we experience unforeseen delays, cost overruns or both in the development of any of our existing product candidates. We cannot be sure that we will be able to raise additional financing when needed on acceptable
terms or at all.

We historically have conducted our business operations on a largely outsourced model, and expect to continue to do so.
Thus, we do not expect to purchase or sell any plant or significant equipment for the foreseeable future.



|Item 3. | Controls and Procedures.
|------- | ------------------------

The Company maintains
disclosure controls and procedures that are designed to ensure that information required to be disclosed in the Companys reports under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the
Commissions rules and forms and that such information is accumulated and communicated to the Companys management, including its Chief Executive Officer and Chief Financial Officer, as appropriate, to allow for timely decisions regarding
required disclosure. In designing and evaluating the disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired
control objectives, and management is required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures.

As required by Commission Rule 13a-15(b), the Company carried out an evaluation, under the supervision and with the participation of the Companys management, including the Companys Chief Executive Officer
and the Companys Chief Financial Officer, of the effectiveness of the design and operation of the Companys disclosure controls and procedures as of the end of the quarter covered by this report. Based on the foregoing, the Companys
Chief Executive Officer and Chief Financial Officer concluded that the Companys disclosure controls and procedures were effective at the reasonable assurance level.

There has been no change in the Companys internal controls over financial reporting during the Companys most recent fiscal quarter that has materially affected, or is reasonably likely to materially
affect, the Companys internal controls over financial reporting.

The Company is not an accelerated filer for the 2006
fiscal year because it remains qualified as a small business issuer. Hence, under current law, the internal controls certification and attestation requirements of Section 404 of the Sarbanes-Oxley act will not apply to the Company until
the fiscal year ended December 31, 2007. Notwithstanding the fact that these internal control requirements do not apply to the Company at this time, management has begun reviewing the Companys internal control procedures to facilitate
compliance with those requirements when they become applicable.



---

PART II  OTHER INFORMATION



|Item 1. | Legal Proceedings.
|------- | ------------------

The Company is not a party to
any material pending legal proceedings.



|Item 2. | Unregistered Sales of Securities and Use of Proceeds.
|------- | -----------------------------------------------------

Not applicable.



|Item 3. | Defaults Upon Senior Securities.
|------- | --------------------------------

Not applicable.



|Item 4. | Submission of Matters to a Vote of Security Holders.
|------- | ----------------------------------------------------

The Company held its Annual Meeting of Stockholders on June 9, 2006. The stockholders elected all of managements nominees for the board of directors and ratified the appointment of Singer Lewak Greenbaum & Goldstein LLP
as the Companys independent registered public accounting firm for the fiscal year ending December 31, 2006. The voting results are as follows:

Election of Directors



|                    |  |            |  |         
|------------------- |  | ---------- |  | --------
|Director            |  | For        |  | Withheld
|Daniel D. Adams     |  | 15,553,096 |  | 16      
|Gregory H. Bailey   |  | 15,528,784 |  | 24,328  
|Kim D. Blickenstaff |  | 15,553,096 |  | 16      
|David T. Hung       |  | 15,552,412 |  | 700     

Ratification of Independent Registered Public Accounting Firm for 2006 Fiscal Year



|           |  |         |  |             |  |                 
|---------- |  | ------- |  | ----------- |  | ----------------
|For        |  | Against |  | Abstentions |  | Broker Non-Votes
|15,552,454 |  | 658     |  | 0           |  | 0               



|Item 5. | Other Information.
|------- | ------------------

On July 14, 2006, W.
Anthony Vernon was elected to the Companys board of directors. A Report on Form 8-K announcing Mr. Vernons election, including the accompanying press release, was filed with the Securities and Exchange Commission on
July 17, 2006.



|Item 6. | Exhibits
|------- | --------



|            |  |                                                                         
|----------- |  | ------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                     
|            | 
|31.1        |  | Certification pursuant to Rule 13a-14(a)/15d-14(a)                      
|            | 
|31.2        |  | Certification pursuant to Rule 13a-14(a)/15d-14(a)                      
|            | 
|32.1        |  | Certification pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002
|            | 
|32.2        |  | Certification pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002



---

SIGNATURES

In accordance with the requirements of the Exchange Act, the registrant has caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.



|                      |  |  |  |                  |  |                           |  |                                                          
|--------------------- |  |  |  | ---------------- |  | ------------------------- |  | ---------------------------------------------------------
|                      |  |  |  | MEDIVATION, INC.
|                      |  |  | 
|Date: August 14, 2006 |  |  |  | By:              |  | /s/    C. PATRICK
MACHADO
|                      |  |  |  |                  |  | Name:                     |  | C. Patrick Machado                                       
|                      |  |  |  |                  |  | Title:                    |  | Senior Vice President and Chief Financial Officer        
|                      |  |  |  |                  |  |                           |  | (Duly Authorized Officer and Principal Financial Officer)