**EXHIBIT 99.1**

 

**Patents Owned or Licensed by MedImmune, Inc.**

 

**Product/****Project**

 

**US Patent****No.**

**Subject Matter**

E. coli

 

6,500,434

Chaperone and Adhesin Proteins: Vaccines, Diagnostic and Methods for Treating Infections

 

 

6,737,063

FimH adhesin proteins and methods of use

 

 

6,913,750

Therapeutic Compounds Structurally Linked to Bacterial Polypeptides

Vitaxin

 

5,753,230

Use of antibodies anti-v3 antibodies to inhibit angiogenesis in tumors and inflamed tissue

 

 

6,531,580

Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same

 

 

6,590,079

Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same

 

 

6,596,850

Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same

 

 

6,887,473

Methods and Compositions Useful for Inhibition of Angiogenesis

MEDI-507

 

5,730,979

Anti-CD2 antibodies and their use in treating T-cell mediated immune responses

 

 

5,817,311

Use of anti-CD2 antibodies in treating T-cell mediated immune responses

 

 

5,951,983

Anti-CD2 antibodies and their use in treating T-cell mediated immune responses

 

 

6,849,258

LO-CD2a Antibody and Uses Thereof for Inhibiting T Cell Activation and Proliferation

EphB4

 

6,579,683

Artery- And Vein-Specific Proteins and Uses Thereof

 

 

6,864,227

Artery- And Vein-Specific Proteins and Uses Thereof

 

 

6,887,674

Artery- And Vein-Specific Proteins and Uses Thereof

 

 

6,916,625

Artery- And Vein-Specific Proteins and Uses Thereof

 

 

6,927,203

Treatment of Metastatic Disease

B cell markers

 

5,484,892

Monoclonal Antibodies that Block Ligand Binding to the CD22 Receptor in Mature B Cells

 

 

5,831,142

Regulatory Elements Controlling Tissue-Specific Gene Expression

STAPH

 

5,571,511

Broadly Reactive Opsonic Antibodies that React with Common Staphylococcal Infections

 

 

5,955,074

Directed Human Immune Globulin for the Prevention and Treatment of Staphylococcal Infections

 

 

6,610,293

Opsonic and Protective Monoclonal and Chimeric Antibodies Specific for Lipoteichoic Acid of Gram Positive Bacteria

 

 

6,632,432

Directed Human Immune Globulin for the Prevention and Treatment of Staphylococcal Infections

 

 

6,939,543

Opsonic and Protective Monoclonal and Chimeric Antibodies Specific for Lipoteichoic Acid of Gram Positive Bacteria

HPV

 

6,153,201

Oral Immunization with Papillomavirus Virus Like Particles

 

 

6,165,471

HPV capsomeres with reduced assembly capacity

 

 

6,261,765

Disassembly/reassembly of Papillomavirus Virus Like Particles

 

 

6,416,945

Disassembly/reassembly of Papillomavirus Virus Like Particles

 

 

6,908,613

Chimeric Human Papillomavirus (HPV) L1 Molecules and Uses Thereof

 

 

6,962,777

In Vitro Method for Disassembly/Reassembly of Papillomavirus Virus-Like Particles (VLPs), Homogenous Capsomer...

RSV

 

4,800,078

Treatment of respiratory disease caused by RSV using human gamma globulin

 

 

5,412,077

Effective Antibody Titers Against Respiratory Viruses

 

 

 

 

 

 

 

5,582,827

Immunoglobulin from plasma for treatment of RSV

 

 

5,824,307

Synagis & other anti-RSV antibodies and their use in treating or preventing RSV infection

 

 

6,565,849

Methods of Enhancing Activity of Vaccines and Vaccine Compositions

 

 

6,818,216

Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment

 

 

6,855,493

Methods of Administration/Dosing Anti-RSV Antibodies for Prophylaxis and Treatment

 

 

6,955,717

Crystals and Structure of Synagis Fab

Strep

 

5,736,367

Vectors and Prokaryotes which Autocatalytically Delete Resistance

 

 

5,798,243

Bacterial Peptide Methionine Sulfoxide Reductase an Adhesion Associated Protein, and Antibiotic Therapies

 

 

5,834,278

DNA encoding pneumococcal MsrA

 

 

5,928,900

Pad1 protein

 

 

5,981,229

DNA encoding Exp1 and PlpA proteins

 

 

6,245,335

Streptococcal choline binding proteins

 

 

6,420,135

Streptococcus pneumoniae polynucleotides and sequences

 

 

6,503,511

Derivatives of Choline Binding Proteins for Vaccines

 

 

6,582,706

Streptococcus Pneumoniae Protein and Immunogenic Fragments for Vaccine

 

 

6,689,369

Immunogenic pneumococcal protein and vaccine compositions thereof

 

 

6,784,164

Choline binding proteins for anti-pneumococcal vaccines

 

 

6,833,356

Pneumococcal protein homologs and fragments for vaccines

IL-9

 

5,116,951

IL-9 receptor protein

 

 

5,132,109

Method for enhancing IgG production using IL-9 and IL-4

 

 

5,157,112

Antibodies which specifically bind mammalian T cell growth factor P40

 

 

5,164,317

Method for enhancing proliferation of mast cells using IL-9

 

 

5,180,678

Methods of detecting IL-9

 

 

5,208,218

Mammalian T cell growth factor P40 protein

 

 

5,246,701

Method to inhibit IgE production using anti-IL-9 antibodies or other IL-9 inhibitors

 

 

5,414,071

Human IL-9 protein

 

 

5,580,753

DNA molecules encoding IL-9 and their use for recombinant production

 

 

5,587,302

Nucleic acid molecules encoding mammalian T cell growth factor P40

 

 

5,734,037

Nucleic acid molecules that hybridize to DNA encoding IL-9

  

 

5,750,377

Methods for production of mammalian T cell growth factor P40

 

 

5,789,237

Nucleic acid molecules that hybridize to DNAs encoding human and murine IL-9 receptors

 

 

5,962,269

Processes and hybridomas for producing anti-IL-9 receptor antibodies

 

 

6,037,149

DNA and RNA molecules that encode Met-IL-9 and their use for recombinant production

 

 

6,261,559

Treating asthmatic symptoms using anti-IL-9 antibodies

 

 

6,602,850

Method of treating asthma using soluble IL-9 receptor variants

 

 

6,645,492

Asthma associated factors as targets for treating atopic allergies including asthma and related disorders

Ethyol

 

5,292,497

Improving toxicity profiles in chemotherapy

 

 

5,424,471

Process for preparing crystalline forms

 

 

5,591,731

Dosage forms of crystalline amifostine

 

 

5,824,664

Agents and methods for inhibiting HIV viral and protein expression using compounds that belong to a family which contains amifostine

 

 

 

 

 

 

 

5,846,958

Methods of stimulating hematopoietic progenitor cells using a compound that belong to a family which contains amifostine

 

 

5,906,984

Methods of stimulating hematopoietic progenitor cells using specific compounds, which include amifostine

 

 

5,994,409

Methods of treating toxicities associated with chemotherapy, a method of treating a nephrodisorder, and a method of treating xerostomia, all of which use a compound that belongs to a family which contains amifostine

 

 

6,051,563

Subcutaneous administration, method of protecting against toxicities associated with ionizing radiation

 

 

6,127,351

Methods of treating or protecting against toxicities associated with chemotherapy using a specific dosing regime, a method of stimulating bone marrow growth, and a method of treating myelodysplastic syndrome, all of which use a compound that belongs to a family which contains amifostine

 

 

6,218,377

Methods of treating or protecting against toxicities associated with specific chemotherapy agents, and a method of protecting normal tissue in cancer patients, both of which use a compound that belongs to a family which contains amifostine

 

 

6,239,119

Methods of treating damaged or infected mucosal tissue using a compounds that belongs to a family which contains amifostine

 

 

6,384,259

Stable Amorphous Amifostine Composition and Methods for the Preparation and Use of the Same

  

 

6,407,278

Stable Amorphous Amifostine Composition and Methods for the Preparation and Use of the Same

 

 

6,489,312

Novel Pharmaceutical Formulations Comprising Aminoalkyl Phosphorothioates

 

 

6,586,476

Methods for Treatment of Neuro and Nephro Disorders and Therapeutic Toxicities Using Aminothiol Compounds

 

 

6,573,253

Methods of the Administration of Amifostine and Related Compounds

 

 

6,753,323

Topical administration of Amifostine and Related Compounds

 

 

6,841,545

Stable Amorphous Amifostine Compositions and Methods for the Preparation of Same

NeuTrexin

 

4,677,219

Substituted Benzonitriles

 

 

4,694,007

Use of Trimetrexate as Antiparasitic Agent

 

 

4,853,221

Method for treating non-small cell lung cancer, head and neck cancers and breast cancer

 

 

5,160,727

Tumor Cell Sensitization Method

 

 

5,716,960

Cystalline glucuronate hydrate salt

 

 

6,017,921

Crystalline glucuronate salt

 

 

6,017,922

Thermally stable crystalline non-salts

 

 

6,258,821

Trimetrexate ascorbate and compositions comprising trimetrexate and ascorbic acid

 

 

6,258,952

Methods of producing monohydrate

 

 

6,576,635

Novel Compositions Comprising Trimetrexate

PALA

 

5,491,135

Methods of treating a viral infections (*e.g.*, hepatitis B and C and secondary to HIV 1)

Platinum

 

4,895,935

Platinum Pharmaceuticals

 

 

4,895,936

Platinum Pharmaceuticals

 

 

4,957,481

Photodynamic therapeutic technique

CMV

 

5,721,354

Human CMV sequences and attenuated viruses

 

 

5,925,751

Human CMV sequences and attenuated viruses

 

 

6,040,170

Human CMV sequences and attenuated viruses

 

 

 

 

 

 

 

6,291,236

Human CMV sequences and attenuated viruses

 

 

6,635,477

Human CMV sequences and attenuated viruses

EBV

 

5,824,508

Non-splicing variants of EBV gp350 protein and gene

 

 

6,054,130

Non-splicing variants of EBV gp350 protein and gene

  

 

6,458,364

Non-Splicing Variants of GP350/220

 

 

6,692,749

Non-Splicing Variants of GP350/220

Influenza

 

5,690,937

Temperature sensitive mutants of influenza

 

 

6,090,391

Recombinant tryptophan mutants of influenza PB2 gene

 

 

6,322,967

Recombinant tryptophan mutants of influenza PB2 gene

 

 

6,528,064

Recombinant tryptophan mutants of influenza

 

 

6,544,785

Helper-Free Rescue of Recombinant Negative Strand RNA Virus

 

 

6,649,372

Helper-Free Rescue of Recombinant Negative Strand RNA Virus

 

 

6,843,996

Immunogenic Composition Comprising an Influenza Virus with a Temperature Sensitive PB2 Mutation

 

 

6,887,699

Recombinant Negative Strand RNA Virus Expression Systems and Vaccines

 

 

 

 

 

 

6,951,754

DNA Transfection System for the Generation of Infectious Influenza Virus

 

 

6,974,686

Novel Recombinant Tryptophan Mutant of Influenza

HSV

 

4,769,331

Recombinant herpes simplex cloning methods and materials

 

 

4,859,587

Recombinant herpes simplex vectors and vaccines

 

 

5,288,641

Herpes simplex as a vector

 

 

5,328,688

Recombinant herpes simplex with 34.5 gene knockout

 

 

5,599,691

Herpes simplex as a vector

 

 

5,641,651

Synthetic HSV promoters and uses

 

 

5,714,153

Recombinant herpes simplex vaccines and vectors

 

 

5,922,328

Gamma 34.5 mutants of herpes simplex viruses

 

 

6,071,692

Herpes simplex as a gene expression vector and vaccine

 

 

6,120,773

Gamma 34.5 gene modification of herpes simplex viruses

Antibody Engineering

 

6,962,701

Methods of Priming the Immunogenic Activity of Vaccines Useful for Eliciting a Protective Immune Response

Negative Stranded RNA Viruses

 

5,166,057

Recombinant negative strand RNA viruses

 

 

5,578,473

Recombinant negative strand RNA viruses

 

 

5,786,199

Recombinant negative strand RNA viruses and vaccines

 

 

5,820,871

Recombinant negative strand RNA viruses – bicistronic

 

 

5,840,520

Recombinant negative strand RNA virus expression systems

 

 

5,854,037

Recombinant negative strand RNA viruses

 

 

6,001,634

Recombinant negative strand RNA viruses

 

 

6,022,726

Attenuated negative strand RNA viruses and methods

 

 

6,316,243

Recombinant attenuated double strand RNA viruses

 

 

6,764,685

Recombinant parainfluenza virus expression systems and vaccines

 

 

6,811,784

Recombinant parainfluenza virus expression systems and vaccines

 

 

6,887,699

Recombinant Negative Strand RNA Virus Expression Systems and Vaccines

VZV

 

6,087,170

VZV gene and mutant VZV viruses

 

 

6,713,296

VZV gene, mutant VZV and immunogenic compositions

HMGB1

 

6,303,321

Antagonists of HMG1 for treating inflammatory conditions

 

 

6,448,223

Antagonists of HMG1 for treating inflammatory conditions

 

 

6,468,533

Antagonists of HMG1 for treating inflammatory conditions

 

 

 

 

 

IFNα IFNR1

 

5,731,169

cDNA fragment coding the alpha interferon receptor gene and process for the preparation of a corresponding protein

 

 

5,861,258

Use of the alpha interferon receptor and cells which express the receptor, for identification of alpha interferon agonists

 

 

5,886,153

Antibodies directed against the alpha interferon receptor

 

 

5,889,151

Purified human alpha interferon receptor

 

 

5,919,453

Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon

 

 

6,475,983

Water-soluble polypeptides having a high affinity for alpha and beta interferons

 

 

6,787,634

Isolated peptide or polypeptide of the extracellular portion of the human interferon receptor (IFN-R)