Flutolanil Dietary Exposure and Risk Assessment DP Number: D4 I 6620 PC Code: 128975



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

MEMORANDUM

DATE: 12/ 12/ 13 WASHINGTON, D.C. 20460

OFFICE OF Ct

l EM ICAL SAFETY AND POLLUTION PREVENTION



### SUB J ECT: F luto l a nil Chronic Aggregate D ietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Action s on 

### Brassica Leafy Vegetables (Crop Gro up 5), Turnip Green s, Peanuts, and Rice
, and for Registrat ion Review.

PC Code: 128975 Decision No.: 480092 Petition No.: NA DP Barcode : D416620 Registration No.: 7 I7 I I -28 Regulatory Action: Section 3 Re gis tration and Registration Review Ri sk Assessment Type: Single Chem ical/ Aggregate TXR No.:NA Case No.: N/ A MRIDNo s. NA



### REV IEWER:

T H ROUGH:

TO: CAS No.: 66332-96

- 5 40 CFR: 

### § 180.484



### Nancy Dodd
, Chemist

# /~**~A/ ~**  Risk Assessment Branch 3 Health Effects Division (HED; 7509P)

David Hrdy, Senior Scient ist

# ~Z(('A/sv~&-L--­ Thu rston Mo rton, Chemist

## "?~**':~ ;-** **~** D ietary Exposure Science Advisory Council (DESAC) Health Effects Division (7509 P)

# ~~is Olinger, Branch Chief 

## /J/j

# ~ ... Ri sk Assessment Branch 3 

# uyL.------'

Healt h Effects D ivision (7509P)

William Cutchin/Erin M a lo ne, RM#20 Registrati on Di vision (7505 P )

Page I of 10Flutolanil Dietary Exposure and Risk Assessment DP Number: 0416620 PC Code : 128975



### Executive Summary



### Chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM -F CID) Version 3.16

. Thi s software uses 2003-2008 food consumption data from the U.S

. Department of Agriculture ' s (USDA's) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA. The analysis

was conducted in support of a human-health risk assessment for the proposed amendments to Section 3 uses offlutolanil on 

### Brassica (cole) leafy vegetables (Crop Group 5), turnip greens , peanuts, and rice, and for registration review

. This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1.

Acute Dietary (Food and Drinking Water) Exposure Assessment

No appropriate endpoint attributable to a s ingle dose was identified

. As no acute dietary endpoint was identified, an acute exposure analysis was not performed.

Chronic Dietary (Food and Drinking Water) Exposure Assessment

Tolerance-level residues combined with 100% crop treated and default processing factors were used to determine the chronic dietary exposure and risk estimates

. The chronic dietary exposure estimates for food and drinking water are below HED's level of concern for the general U

. S. population ( 11% of the chronic population adjusted dose (cPAD))

. The most highly exposed population subgroup was all infants (<1 year old) at 29% of the cPAD. Drinking water was incorporated directly into the dietary assessment.

Cancer Dietary (Food and Drinking Water) Exposure Assessment

Flutolanil is c lassified as "not likely to be carcinogenic to humans," so a quantitative cancer dietary assessme nt was not conducted.

I. 

### Introduction


### Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e

. g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% ofthe PAD. References that di scuss the acute and chronic risk assessments in

more detail are avai lable on the EPA/pesticides web site: ''Available Information on Assessing Exposure from Pesticides
, A User's Guide;' 2 1

-JUN-2000, web link:

Page 2 of 10Flutolanil Dietary Exposure and Risk Assessment DP Number : 0416620 PC Code: 128975



### http: //www .epa.gov /f

edrgstr/EPA-PEST /2 000/July/Day-12/60 61.pdf; or see SOP 99.6 (20- AUG-1999).

The mo st recent die tary risk assessment for fluto lani l was co nducted b y Kri stin Rury (9 11 0 / 10
, DP Number D371494 )

.
II. Residue Information

Flutolan il Use:

Nichino America
, Inc

. has proposed 1) adding a banded application to the existing broadcas t

use fo r pe anuts on the suspension concentrate (SC) label ; 2) addi n g the Brass ica 

### (cole) le afy vegetabl es crop group and turnip greens to the SC label using dry flowable (DF) residue data ; 3) slightly modifying the es tablished SC u se rate on ric e.

For the current act ion, HED has examined data to support the proposed amendments to Section 3 u ses of flutolanil on Brassica 

### (cole) leafy vegetables (Crop Group 5), turnip greens , peanuts, and rice, and for registration review.

To lerances are currently estab lished (40 CFR § 180 .484) for res idues offlutol ani l
, including its metabolites and degradates. Compliance w ith the tolerance levels is to be d eterm ined by

measuring only flutol anil and its metabo lites converted to 2

- (trifluorometh y l)be nzoic ac id an d calculated as flutolanil.

T olerances are es tab li s hed [40 CFR § 180.484(a)] on cotton , peanut, potato , rice
, soybean
, turnip greens , Brassica 

### leafy vegetables
, and li vesto ck commodities at level s ranging from 0

.05 ppm to 25.0 ppm. Inadv ertent o r ind irect tolerances [ 40 C FR § 180.484(d)] are also current ly established on wheat commodit ies at le vels ran ging fro m 0.05 ppm to 2.5 ppm

.

Residue Data Used for Chronic Assessment s

The estab li s hed tolerances in 40 CFR § 180.484 or recomme nded toleranc es (D413582
, N. Dodd
, 12112113) were used to conduct the chro nic analysis. The subject amendments do n ot affect tolerance levels for livestock commodities included in DEEM. Default processing factors were used

.
The USDA Pesticide Data Program (PDP) monitored p esticide residue s in catfish in 2008
, 2009
, and 20 1 0. In general
, pesticide res idue s would n ot be expected to be found in fish unless the pes ticide b ioaccumula te s o r has an aquatic use. To determine whether or not

re sidues are present in fish, HE D no w routinely checks PDP monitorin g data regardless of the pesticid e's uses and physicochemical properties. In 2008, PDP analyzed 552 samples of catfish for flutolanil res idues. None of the s amples contained detectable residues of flutolanil. PDP did not analyze catfish samples for fluto lanil in 2009 or 2010. As a result
, residues in fi sh were not included in the assessment.

Page 3 of 10Flutolanil Dietary Exposure and Risk Assessment DP Number: 0416620 PC Code: 128975

III. Percent Crop Treated Information



### In the chronic analysis, 1 00% crop treated assumptions were used.

IV. Drinking Water Data



### The drinking water residues used in the dietary assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: "Tier !III Estimated Drinking Waters Concentrations ofFlutolanil for the New Uses on Peanuts (Banded Applications), Brassica 

### Leafy Vegetables (Crop Group 5) Plus Turnip Greens
, Turf and Ornamentals for the Product Convoy® Fungicide, and for Increased Annual Rate on Turf for the Product ProStar® 70WP Fungicide" (J. Melendez, D414000, 12 / 12 / 13) and were incorporated directly into this dietary assessment. Water residues were incorporated in the DEEM Food Commodity Intake Database (FCID) into the food categories "water
, direct, all

sources " and "water, indirect, all sources."

The Tier 

### 1 / 11 Estimated Drinking Water Concentrations (EDWCs) were calculated using the Tier I Rice Model v.l.O (surface waters), the Tier II 

### PRZM/EXAMS models (surface waters), the Tier 

### IIII model PRZM-GW (in the Tier 

### I mode), and the Tier 

### I groundwater model SCIGROW for use in the human health risk assessment.

Results obtained from the models that yielded the highest EDWCs for flutolanil are summarized in Table 1. The maximum screening EDWC for chronic exposure is 2530 ppb
, found in groundwater associated with the use on turf. Residues in surface water are lower. The maximum chronic EDWC in surface water is**531** 

### ppb, which is associated with the use
on nee.

Because the Metabolism Assessment Review Committee (MARC) determined on 12/ 1611999 that only the parent needs be included in drinking water exposure assessments for flutolanil (DP Barcode D261391, M

. Xue, 1/ 6/00)
, no degradates were modeled in this assessment.

Tab l e 

### 1. M a x imum Es timated Drinking Water Concentrations (EDWCs) based on Ground Application of Flutola n il on Turf and Ground/Aerial Application on Rice Drinking Water Model Scenario!Use 1 Acute (ppb) Chronic (ppb) 

# l Cancer/Chronic (ppb) Source Surface water Tier l Rice Model Rice 531 <531 Groundwater PRZM-GW WI Sand Turf 2730 2530 1 For nee , the apphcatton rate IS 0.980 lb a.1 ./ A

/ season; for turf, th e apphcat10n rate IS 17 .I lb a.1 ./ A

/year.

V. DEEM-FCID Program and Consumption Information



### The flutolanil chronic dietary exposure assessment was conducted using the DEEM

- FCID
, Version 3

. 16, which incorporates 2003

-2008 consumption data from USDA's NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days. Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e. g

. , apples, peeled fruit

- cooked; fresh or N/S;
Page 4 of 10Flutolanil Dietary Exposure and Risk Assessment DP Number: D416620 PC Code: 128975



### baked ; or wheat flour

- cook ed ; fre sh or N/S, baked) using publicly availabl e recipe tran s latio n fil es developed jointly by US D A/ARS and EP A. For chronic exposure assessment, consumption data are averaged fo r the enti re U.S. pop ulation and within popu lation subgroups. Based on analys is of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey re s pond ents , HED concluded th at it is most appropriate to report risk for the following population subgroup s: the general U.S

. population
, all infants (< 1 year old), children 1-2
, children 3

- 5, children 6-12, youth 1 3- 1 9, adults 20-49
, fema les 13-49
, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange o r orange juic e) on the food commodity re s idue li s t i s multipl ied by t he average daily consumption estimate for th at food/food fo rm to produce a resi due intake
est imate. The resul ting residue intake estimate for each food/food form is su mmed with the

residue intake estimates for all other food/food forms o n the commo di ty residue lis t to arrive at the total average estimated exp osure. Exposure i s expressed in m glkg body weight/day and as
a percent of the cPAD

. This procedure i s performed for each p op ulati on subgroup.



### VI. Toxico logical Information

T he doses an

. d endpo ints for dietary risk assessment were confirmed by the flutolanil risk assessment team. A summary of the information is presented in Table 2. F lutol anil has been classified as " not l ikely to be carcinogenic to humans."

Tabl e 2. S u mmary of Toxicological Doses a nd E ndpoints for F luto l an il for Use in D ietary Expos ure Ris k Assessments RID, PAD, Exposure / Point of Uncerta in ty/ Level of FQPA Safety Concern for Stud y and Toxico log ical Effects Scenario Departure Factors Risk Assessment Acute Di etary (General Population
, No r is k is expected from this exposure scenario s ince no hazard was identified from including Infants appropriate oral toxicity studies including developmental toxicity studies in rats and and Children and rabbits. Fe males 13-49 years of age)

Chronic RID = 2 -year Ch roni c study in dogs.
UFA= lOX 0.5 MRID 40342922
Chronic Dietary NOA EL= 50 UFH= lOX mg/kglday LOAEL = 250 mglkg/day based on (All Populations) mg/kglday FQPA SF= in creased incidence of G I toxicity
IX cPA D = 0.5 ( emesis
, salivation
, soft stool, decrease mg/kglday food consumption and decreased body weight) Pomt of Depa rture (POD) = A data po mt o r an est u nated pomt that IS den ve d from observ ed dose -response data and used to mark the beginning o f extrapolation to deter mine risk associated w ith lower e nvironmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed a d v erse effect level. UF =uncertainty fac t or. UFA= extrapolation from animal to human (interspecies)

. UFH = potential variation in

Page 5 of 10Flutolanil Dietary Ex po s ure and Ri s k Assessment DP N umber: 0416620 P

C Code: 128975

sensitivity among members of the human p opulation (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adj usted d ose (a= acute, c = chronic). RID = reference dose.



### VII. Results/Discussion

Res ult s of Chronic Dietary (food and Drinking Water) Exposure and Risk Analysis

T he res ult s of the chronic dietary exposure and risk analysis are reported in T able 3 below. The chronic ri s k estimates were below the Agency's level of concern (<1 00% cPAD) for the general U.S. population (11% ofthe cPAD) and all population s ubgroups. The most highly exposed population subgroup was all infants ( < 1 year old) at 29% ofthe cPAD

.

Table 3. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Flutolanil.

Acute Dietary C hro ni c Dietary Cancer Population Subgr o up Dietar y Dietary D i etary Exposure %aPAD Expos ure %cPAD Ex p osure Risk (mg/k2/day) (mg/kg/day) (mg / k2/day) General U.S. Population 0

. 055661 I I
A ll I nfants ( < 1 year o l d)* 0.144721 

### 29
Children 1-2 years old 0

. 084103 17
C hil dren 3-5 years old 0

. 070104 14
Childre n 6-12 years old N/A N IA 0.049893 10 N/ A N/ A
Youth 13-19 years old 0.040594 8.1
Adu lts 20-49 years old 0.055422 11
Adults 50-99 years old 0.053959 II
Females 13-49 years old 0

. 054666 II
*Th e s ubp op ulatton wtth the htghest n s k esttmates.



### VII. Characterization of Inputs/Outputs

The chronic a ss essment was an unrefined as se ss ment. To lerance-level residues, 10 0% crop treated, and defau l t process ing factors were used. A s the exposure estimates to all population

sub groups were low
, it was n ot necessary to make refinements to the chronic dietary analysis

. Further refinement to the analysis could be made through the use of percent crop treated
, anticipated re si dues, empirical processing factors, and/or mo ni toring data

.



### VIII. Conclusions

Based on conservative assumptions, the chronic dietary (food and drink ing water) risk estimates are well below HED's level of concern for the gene ral U

. S. population and a ll population s ubgroups

.

Page 6 of 10Flutolanil Dietary Exposure and Risk Assessment PC Code: 128975



### IX. List of Attachments

Attachment 1: Chronic Food and Drinking Water Residue Input File Attachment 2: Chronic Results File

Page 7 of 10 DP Number: 0416620Flutolanil Dietary Exposure and Risk Assessment DP Number: 0 416620 PC Code: 128975



### Attachment 1: Chronic Food and Drinking Water Residue Input File

Filename : C :\Do cuments and Se tt ings\NDODD\ M y Oocuments\DEEM Version 3.16\Flutolanil\FLUTOLANI L chron ic 12 08 1 3.R08 Chemical: FLUTOLANIL RfD(Chronic): .S mg/kg bw/day NOEL(Chronic): 50 mg/ kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Da te creat ed/last modified : 12

- 09-2013/19:57:40 Program ver. 3.16, 03-08-d

Crop EPA Code Grp Commodity Nam e Def Res (ppm)

0103296000 1C 0103297000 1C 0103297001 1C 0103298000 1 C 0103298001 1C 0103299000 1 C 0 1 0329900 1 1C 0103300000 1C 0103300001 1C OS01061000 SA 0501061001 SA 0501062000 SA 0501064000 SA OS01069000 SA 0501071000 SA OS01072000 SA OS01083000 SA 0501196 000 SA 0502063000 SB OS02070000 SB 0502 11 7000 SB OS02194000 SB OS02229000 SB 05023 18 000 5B 0502389000 SB 0600347000 6 0600349000 6 0600349001 6 06003SOOOO 6 06003 S 0001 6 0603348000 6C 0603348001 6C 1S00323000 1 S 150032300 1 1 5 1 S00324000 15 1 S00324001 15 1S0032SOOO 1S 1S0032S001 1S 1500326000 15 1500326001 15 1500401000 15 1S00 4 01001 15 1S00402000 1S 1 500402001 1S 1 500 4 03000 1S 150040 4 000 15 2003128000 20C 2003128001 20C 31000 44 000 31 3100044001 31 3100045000 31 3100046000 31 3100046001 31 3100047000 31 310004 7 001 31 Potato, chips Potato, dry (g ranules / flakes) Potato, dry (granules/ flakes)

- b Potato, flour Potato
, flour-babyfood Potato, tuber, w/pee l Potato, tuber, w/pee l

- babyfood Potato, tube r, w/o peel Potato, tube r , w/o peel-babyfood Broccoli Broccoli-babyfood Broccoli, Chinese Brussels sprouts Cabbage Cabbage, Chinese, napa Cabbage, Chinese, mustard Cauliflower Kohlrabi Broccoli raab Cabbage, Chin ese, bok choy Collards Kale Mustard greens Rape greens Turnip, greens Soybean, seed Soybean, soy milk Soybean, soy milk

- babyfood or in Soybean, oil Soybean, oil-bab y f ood Soybean, flour Soybean, flour

- babyfood Rice
, white Rice, white -b abyfood Rice, brown Rice, brown-babyfood Rice, flour Rice, flour-babyfood Rice, bran Rice, bran

- babyfood Wheat, grain Wheat, grain

- babyfood Wheat, flour Wheat, flour-b abyfood Wheat, germ Wheat, bran Cottonseed, oil Cottonseed, oil- babyfood Beef, meat Beef, meat-babyfood Beef, meat, dried Beef, meat byproducts Beef, meat byproducts

- babyfood Beef, fat Beef, fat -babyfood 0.200000 0.200000 0.200000 0.200000 0.200000 0 .2 00000 0.200000 0.200000 0

. 200000 0.200000 0.200000 0.200000 0.200000 0.200000 0 .2 00000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0

. 200000 0.200000 0 .2 00000 0.200000 0.200000 7

. 000000 7

. 000000 7.000000 7.000000 7.000000 7.000000 10.000000 10.000000 

### o.osoooo o.o s oooo o.osoooo 0 .050000 0 .0 500 00 0.200000 0

. 200000 0

. 200000 0.050000 

### o.osoooo o.osoooo 0.050000 

### o.osoooo 0.100000 0.100000 Pag e 8 of 10 Adj.Factors Ill 112

1.000 6.500 6.500 6.500 6.500 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1. 000 1 .000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1. 000 1.000 1 .000 1

. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1 .000 1. 000 1.000 1.00 0 1. 000 1.000 1.920 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1

. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 CommentFluto lanil PC Code: 12 8975

3 1 00048000 31 31 00049000 31 3100049001 31 3200169000 32 3200170000 32 3200171000 32 3200172000 32 3200173000 32 3300 1 89000 33 340 0290000 3 4 34 00290001 34 3400291000 34 3400292000 34 3400292001 34 3400293000 34 3400293001 34 3400294000 34 3400295000 34 3500339000 35 3500339001 35 3500340000 35 3500341000 35 3500341001 35 3500342000 35 3500343000 35 3600222000 36 360022 2001 36 360022 300 0 36 3600223001 36 3600224000 36 3600224001 36 3600225001 36 4 000093000 40 40 00093001 40 4000094000 40 4000095000 40 4000095001 40 4000096000 40 4000096001 40 4000097000 40 4000097001 40 5000382000 50 5000382001 50 5000383000 50 500038300 1 50 5000384000 50 50003840 01 50 50 00385000 50 5000385001 50 5000386000 50 5000386001 50 6000301000 60 6000302 000 60 6000303000 60 6000304000 60 600030 5000 60 7000145000 70 7000145001 70 7000146000 70 700014 6001 70 7000147000 70 7000147001 70 860 1 000000 86A 8602000000 86B 950026 3000 0 9500264000 0 9500265000 0 Dietary Exposure and Risk Assessment

Beef, k idney Beef
, liver Beef, liver-babyfood Goat, meat Goat, meat byproducts Goat, fat Goat, kidney Goa t , liv er Horse, meat Pork, meat Pork, meat

- babyfood Pork, skin Pork, meat byproducts Pork, meat byproducts-babyfood Pork, fat Pork, fat-babyfood Pork, kidney Pork, liver Sheep, meat Sheep, meat-babyfood Sheep, meat byproducts Sheep, fat Sheep, fat

- babyfood Sheep, kidney Sheep, liver Mi lk, fat M

ilk, fat-baby f ood/infant formu M

ilk, nonfat solids M

i lk, nonfat solids-baby food/in Milk, water Milk, water

- babyfood/infant form Milk, sugar (lactosel

- baby food/ Chicken, meat Chicken
, meat-baby f ood Chicken, liver Chicken, meat byproducts Chicken, meat bypr oduc ts- babyfoo Chicken, fat Chicken, fat-babyfood Chicken, skin Chicken, skin

- babyfood Turkey, meat Turkey, meat-baby f ood Turkey, liver Turkey, live r-babyfood Turkey, meat byproducts Turkey, meat byproducts-babyfood Turkey, fat Turkey, fat-babyfood Turkey, skin Tu rke y, skin-baby food Poultry, other, meat Poultry, othe r, liver Poult ry , other, meat byp roducts Poultry, other, fat Poultry, other, skin Egg, whole E

g g , whole-babyfood E

g g, white Egg, white ( solids)-babyfood Egg
, yolk E

g g, yolk-babyfood Wate r, di rec t, all sourc es Water, indirec t , a ll sources Peanut Peanut, butter Peanut, oi l 1.000000 2.000000 2.000000 0.050000 0.050000 0.100000 1

. 000000 2

. 000000 0

. 050000 0.05000 0 0.050 000 0.050000 0.050000 0.050000 0.100000 0.100000 1.000000 2.000000 0.050000 0.0500 00 0.050000 0.100000 0.100000 1. 000000 2.0 00000 0.050000 0.050000 0.050000 0.05000 0 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0

. 050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0

. 050000 0.050000 0.05000 0 0 .050000 0.050000 0.050000 0.050000 0.050000 0

. 050000 0.050000 0.05000 0 0.05000 0 0.0500 00 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 2.530000 2

. 530000 0

. 500000 0.500000 0 .5 00000

Page 9 of 10 1 .000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1 .000 1. 000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1 .000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1 .000 1 .000 1.000 1.000 1.000 1.000 1.000 1 .000 1. 000 1. 000 1.000 1. 000 1.000 1.000 1.000 1.000 1. 000 1. 000 1 .000 1.000 1.000 1. 000 1. 000 1. 000 1.000 1.000 1.000 1.000 1

. 000 1.8 90 1.000 DP Number: 0416620

1 .000 1.000 1 .000 1.000 1.000 1 .000 1.000 1

. 000 1.000 1 .000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1 .000 1.000 1.000 1 .0 00 1. 000 1 .000 1 .000 1

. 000 1 .000 1 .000 1 .000 1.000 1. 000 1 .000 1.000 1.000 1

. 000 1 .000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1 .000 1.000 1.000
1. 000 1.000 1.000 1.000 1. 000 1 .000 1.000 1.000 1 .000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1 .000 1.000 1 .000 1 .000Flutolani l Dietary Exposure and Ri sk Assessment DP Number : 0416620 P

C Co d e: 1 28975



### Attachment 2: Chronic Results File

U.S. EPA Ver. 3.16, 03-08- d OEEM-FCIO Chronic analysis for FLUTOLANIL NHANES 2003-2008 2-d a y Residue file name: C:\Documen ts and Settings \NDOOO\My Oocuments\OEEM Version 3.16\Flutolanil\FLUTOLANIL chronic 120813.R08 Adjustment factor n2 used

. Analysis Date 12-09-2013/ 1 9:59: 34 Residue file dated: 12-09-2013/19:57:40 Reference dose (Rf O, Chronic ) = .s m g / kg bw/day

Tota l exposure by population subgroup

Total Exposure
Population

S ubgroup

Tota l US Population Hispanic N

on-Hisp-White N

on- H isp-Blac k N

on-Hisp-Other N

ursing Infants N

on-Nursing Infants Female 13+ PREG Children 1-6 Children 7-12 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13-50 Children 1-2 Children 3-5 Children 6-12 Youth 13-19 Adults 20- 4 9 Adults 50-99 Female 13-49 mg/kg b o dy wt/d ay

0.055661 0.05 4 223 0.056693 0

. 046289 0.067942 0.052902 0.185730 0.052138 0.074014 0.047490 0.038475 0.042683 0.052023 0.057421 0.052774 0.1 4472 1 0.05 4711 0.08 41 03 0.07010 4 0.049893 0.0 4 059 4 0.055 4 22 0.053959 0.05 46 66

Page 10 of 10 Percent of Rfd

11 .1\; 1 0.8% 11. 3%

9.3% 13.6 \ 10.6% 37. 1% 10.4% 14.8 \

9.5% 7.7 % 8.5% 10.4% 11.5% 10.6% 28.9\ 10 .9% 1 6.8% 14.0% 10.0%

8.1% 11.1% 10.8% 10.9%