Exhibit 12.1

Cephalon, Inc.  Computation of Ratios of Earnings to Fixed Charges(In thousands)

|                                                 |                                                                                    | Year Ended December 31, |        
|------------------------------------------------ | ---------------------------------------------------------------------------------- | ----------------------- | -------
|
|Determination of earnings:                       |                                                                                    |                         |        
|Pre-tax income (loss) from continuing operations |                                                                                    | $                       | 130,314
|                                                 | Add:                                                                               |                         |        
|                                                 | Amortization of interest capitalized in current or prior periods                   |                         |        
|                                                 | Fixed charges                                                                      |                         |        
|                                                 |                                                                                    |                         |        
|Total earnings                                   |                                                                                    | $                       | 161,505
|                                                 |                                                                                    |                         |        
|Fixed charges:                                   |                                                                                    |                         |        
|                                                 | Interest expense and amortization of debt discount and premium on all indebtedness |                         |        
|                                                 | Appropriate portion of rentals                                                     |                         |        
|                                                 |                                                                                    |                         |        
|                                                 | Fixed charges                                                                      |                         |        
|                                                 |                                                                                    |                         |        
|                                                 | Capitalized interest                                                               |                         |        
|Total fixed charges                              |                                                                                    | $                       | 31,191 
|                                                 |                                                                                    |                         |        
|Ratio of earnings to fixed charges(1)            |                                                                                    |                         | 5.18   
|                                                 |                                                                                    |                         |        
|Deficiency of earnings to fixed charges          |                                                                                    |                         |       
|                                                 |                                                                                    |                         |        

---

---



QuickLinks