Mandipropamid Dietary Exposure and Risk Assessment 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

DP Number: D428940 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

MEMORANDUM 

Date: February 23, 2016 

SUBJECT: Mandipropamid: Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for the Section 3 Amended Use of the Fungicide on 

Potato to Add Seed Treatment Use. 

PC Code: 036602 

Decision No.: 497834 

Petition No.: 4F8329 

Risk Assessment Type: Dietary 

TXR No.: None 

MRID No.: None 

DP Number: 0428940 

Registration No.: 100-1254 

Regulatory Action: Section 3 

Case No.: 7058 

CAS No.: 374726-62-2 

40 CFR: §180.637 

FROM: Elizabeth Holman, Physical Scientist ~ H.re--

Risk Assessment Branch 2 

Health Effects Division (7509P) 

THROUGH: David Hrdy, Senior Bi og ~/~ 

K:istin Rury, Bi.ologist ¥- ~ 

Dietary Exposure Science Adv isory Counci l <DESAC) 

Health Etlects Division (7509P) 

TO: Tony Kish and Shaunta Hill, RM Team 22 

Fungicide Branch (FB) 

Registration Division (RD), 7505P 

Executive Summary 

Chronic aggregate dietary [food and drinking water] exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity 

Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption 

data from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition 

Examination Survey, What We Eat in America, (NHANES/WWEIA). The analysis was 

Page 1of10 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940 

Page 2 of 10 

on potatoes to add seed piece treatment. This memorandum was reviewed by two peer reviewers 

of the DESAC, per DESAC SOP 2012.1. 

In calculating dietary risk estimates, HED has compared the chronic population adjusted dose 

(cPAD) to the respective estimated dietary exposures. Typically, HED has concerns regarding 

dietary risk when the estimates exceed 100% of the cPAD. No single dose effects were noted in 

the toxicity studies for mandipropamid, so an acute dietary point of departure was not selected 

and an acute dietary exposure and risk assessment was not conducted. In addition, 

mandipropamid is considered “not likely” to be carcinogenic; therefore a cancer assessment was 

not performed. 

Chronic Dietary (Food + Drinking Water) Exposure Results and Characterization 

An unrefined chronic dietary analysis for mandipropamid was conducted. Specifically, the 

assumptions underlying this unrefined assessment were 100% crop treated (CT), HEDrecommended tolerance levels or tolerance level residues (with the exception of vegetable, 

tuberous and corm, crop subgroup 1C (which includes the SYN 500003 metabolite)), and default 

DEEM-FCID (ver. 7.81) processing factors (with the exception of chemical-specific empirical 

processing factors (PF) described in Table 1). The mean (i.e., relevant to chronic exposure) 

drinking water estimate of 79 ppb (μg/L) was provided by the Environmental Fate and Effects 

Division (EFED) and directly incorporated into the chronic assessment. The estimated drinking 

water concentration (EDWC) of 79 μg/L reflects ground water exposure, and was used for 

chronic exposure. 

For the general U.S. population, the exposure from food and drinking water utilizes 26% of the 

chronic population adjusted dose (cPAD). The chronic dietary risk estimate for the most highly 

exposed population subgroup, children 1-2 years old, is 42% of the cPAD. The chronic dietary 

risk assessment shows that for all included commodities, the chronic dietary risk estimates are 

below the Agency’s level of concern (i.e. <100% cPAD). 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, e.g. no observed adverse effect level (NOAEL), lowest observed 

adverse effect level (LOAEL)) divided by the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2007-0780-0001; or see SOP 

99.6 (20-AUG-1999). 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940 

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The most recent dietary risk assessment for mandipropamid was conducted by D. McNeilly 

(D412238, 08/27/2013).

II. Residue Information

Tolerances: Permanent tolerances for residues of mandipropamid are listed in 40 CFR §180.637 

and are expressed in terms of mandipropamid [4-chloro-N-[2-[3-methoxy-4-(2-

propynyloxy)phenyl]ethyl]- α-(2-propynyloxy)-benzeneacetamide] in/on a variety of raw 

agricultural commodities (RACs), ranging from 0.01 ppm to 240 ppm. Based on the registered 

and proposed uses, livestock commodity tolerances are not required, as there is no reasonable 

expectation of finite residues in livestock (40CFR §180.6[a][3]) (D428278, W. Drew, 

02/23/2016). 

Residues of Concern (residues included in dietary exposure analysis): For most agricultural 

commodities the residues of concern for tolerance enforcement and risk assessment are parent 

only, except for vegetable, tuberous and corm, subgroup 1C where the metabolite SYN 500003 

has been included for exposure/risk assessment (Residue chemistry memoranda D333121 & 

D328534; D. McNeilly; 28-Aug-2007). For drinking water, the parent plus the metabolites SYN 

500003 and SYN 504851 are included in the exposure/risk assessment. 

Current Tolerances: The chronic dietary risk assessment was based on the assumption of 

tolerance-level residues for all commodities with existing tolerances. 

Recommended Tolerance: The HED-recommended tolerance-level residues for the proposed 

amended use on potato (D428278, W. Drew, 02/23/2016) is 0.09 ppm, with the amended 

tolerance being issued for the entire vegetable, tuberous and corm, subgroup 1C. For the 

purposes of this chronic dietary risk assessment, this subgroup was assessed at 0.115 ppm 

(D428278, W. Drew, 02/23/2016), which assumes tolerance-level residues of parent 

mandipropamid (0.09 ppm) and also includes the SYN 500003 metabolite in parent-equivalents 

(at 0.025 ppm). 

 Tolerance Summary for Mandipropamid. 

Commodity Established 

Tolerance 

(ppm) 

Proposed 

Tolerance 

(ppm) 

Tolerance 

Recommended 

by HED (ppm)

Comments; Correct Commodity 

Definition

Vegetable, tuberous and corm, 

subgroup 1C 

0.01* None 0.091 Based on the submitted potato field 

trial data for seed treatment. 

* A tolerance is currently established at the listed tolerance level in the corresponding commodity. 1

 For the purposes of the dietary exposure assessment, 0.115 ppm has been used for subgroup 1C commodities, in 

order to account for the parent + SYN 500003 metabolite residues. 

Residue Data used for the Chronic Dietary Assessment: HED used recommended and 

established tolerance-level residues and assumed that 100% of the crops were treated with 

mandipropamid for the chronic dietary assessment. As summarized in Table 1, DEEM default 

processing factors were used for the following commodities: grape juice, dried onion, dried 

potato, dried tomato, tomato puree, and tomato paste; an empirical processing factor was used 

for grape, wine/sherry (1.5 ppm). A processing factor was not used for grape, raisin because a 

raisin tolerance value is currently established. The USDA Pesticide Data Program (PDP) 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940 

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monitored pesticide residues in catfish in 2008, 2009, and 2010. In general, pesticide residues 

would not be expected to be found in fish unless the pesticide bioaccumulates or has an aquatic 

use. To determine whether or not residues are present in fish, HED now routinely checks PDP 

monitoring data regardless of the pesticide’s uses and physicochemical properties. However, 

PDP did not analyze catfish samples for mandipropamid. As a result, residues in fish were not 

included in the assessment. 

Table 1. Mandipropamid Processing Factors. 

Commodity Processing Factors (ppm) 

Grape 

 Raisin Not used, raisin tolerance value was used 

 Juice 1.2 

 Wine/Sherry 1.5 (empirical value) 

Potato – dry 6.5 

Onion – dried 9.0 

Tomato 

 Paste 5.4 

 Puree 3.3 

 Dried 14.3 

III. Percent Crop Treated Information 

The chronic assessment is based on 100% crop treated assumptions for all commodities. 

IV. Drinking Water Data 

Drinking Water Exposure Assessment for Proposed Section 3 New Uses on: Basil, Ginseng and Succulent Beans; 

and Expanded Uses on Bulb Vegetables, Cucurbits, Grapes, and Fruiting Vegetables including Tomatoes., D409108, 

R. Shamblen, 7/9/2013. 

EFED conducted a Tier 1 drinking water exposure assessment for the fungicide mandipropamid. 

PRZM-GW was used to estimate mandipropamid exposure in ground water. Maximum 

estimated drinking water concentrations (EDWCs) in ground water are 87 and 79 μg/L for acute 

and chronic exposures, respectively. These values are as much as 480 times higher than SCIGROW model results. Maximum acute and chronic EDWCs in surface waters are 79 and 9.0 

μg/L, respectively. EFED has concluded that the proposed amended use on potato has no impact 

on the drinking water estimates (based on email communication with B. Anderson, 08/24/2015). 

Therefore, the drinking water estimates from the existing use pattern have been used in this 

assessment. 

Table 2. Tier 1 Estimated Drinking Water Concentrations (EDWC) for Maximum 

Mandipropamid Use Patterns.

Drinking Water Source 

(Model, Version)

PCA

(%) 

Crop Use Pattern 

(Maximum Annual Rate) 

Acute 

(μg/L)

Chronic 

(μg/L)

Surface Water (FIRST, 1.1.1) 91 Tomato & Basil 

(2.08 lbs a.i./A) 79 9.0 

Ground Water (PRZM-GW, 1.01) N/A Tomato & Basil 

(2.08 lbs a.i./A) 87 79 
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Ground Water (SCI-GROW, 2.3) N/A Tomato & Basil 

(2.08 lbs a.i./A) 0.18 

Abbreviations: A= acre; a.i. = active ingredient; μg = micrograms; lbs = pounds (US); N/A = not applicable 

The Total Residue (TR) modeling approach (USEPA, 2013) was used to estimate aerobic aquatic 

half-lives, and estimate drinking water concentrations in surface waters. Previous drinking water 

assessments calculated separate half-lives for the parent compound and two degradates of 

concern, for which exposure was estimated with separate model runs. Simple addition of the 

exposure estimates for mandipropamid and it’s degradates of concern was used to generate 

estimated drinking water concentrations. Previous authors acknowledge this approach is 

conservative because the exposure estimates may not be temporally coincident. The TR method, 

however, tallies the parent compound and it’s degradates of concern prior to calculating a Total 

Residue half-life using PestDF. 

The PRZM-GW chronic ground water value was higher than the surface water value. As a 

result, the ground water value was incorporated directly into these dietary assessments under the 

DEEM-FCID food categories “water, all sources” and “water, indirect, all sources.” The FIRST 

model and its description are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

V. DEEM-FCIDTM Program and Consumption Information

The mandipropamid chronic dietary exposure assessment was conducted using the DEEM-FCID, 

Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption 

data are averaged for the entire U.S. population and within population subgroups. However, for 

acute exposure assessment, consumption data are retained as individual consumption events. 

Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary 

patterns and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old. 

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup. 

VI. Toxicological Information
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HED evaluated the toxicology data base of mandipropamid and selected a dose and endpoint for 

chronic dietary risk assessment based on evidence of liver toxicity. No acute dietary exposure 

assessment for mandipropamid has been conducted because no appropriate endpoint attributable 

to a single dose was identified. There were no treatment-related tumors observed in 

carcinogenicity studies in rats and mice and mandipropamid is classified as “Not likely to be a 

human carcinogen.” Therefore, cancer risk is not a concern for this chemical. Doses and 

toxicological endpoints selected for the chronic dietary exposure scenario are summarized in 

Table 3. 

Table 3. Summary of Toxicological Doses and Endpoints for Use in Dietary Human Health Risk 

Assessments for Mandipropamid 

Exposure 

Scenario 

Dose Used in Risk 

Assessment, UF 

POD 

FQPA SF and Level of 

Concern for Risk 

Assessment 

Study and Toxicological Effects 

Acute Dietary (All 

populations, 

including infants and 

children) 

None None Not selected. 

No appropriate dose and endpoint could 

be identified for any population group. 

Chronic Dietary 

(All populations) 

NOAEL= 5 

mg/kg/day 

UFA= 10x 

UFH= 10x 

Chronic RfD = 0.05 

mg/kg/day 

FQPA SF =1 

cPAD = chronic RfD 

 FQPA SF 

= 0.05 mg/kg/day 

Chronic toxicity – dogs 

LOAEL = 40 mg/kg/day, based on 

evidence of liver toxicity (increased 

incidence and severity of microscopic 

pigment in the liver and increased 

alkaline phosphatase activity in both 

sexes as well as increased alanine 

aminotransferase activity in males). 

Cancer (oral, dermal, 

inhalation) 

There were no treatment-related tumors observed in carcinogenicity studies in rats and 

mice. Classified as “Not likely to be a human carcinogen.” 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population adjusted dose (a = acute, c = chronic). RfD = reference dose. 

VII. Results/Discussion 

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of 

the PAD. The DEEM-FCIDTM analysis estimates the dietary exposure of the general U.S. 

population and various population subgroups. Table 4 lists the results of the chronic dietary 

exposure analyses for the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years 

old. 

Results of Chronic Dietary Exposure Analysis 

In the chronic dietary exposure analysis, the most highly exposed population subgroup is 

children 1-2 years old which utilizes 42% of the cPAD (Table 4). The general U.S. population 

utilizes 26% of the cPAD. 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940 

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Table 4. Summary of Dietary Exposure and Risk for Mandipropamid (Food and Drinking 

Water)

Population Subgroup 

Acute Dietary Chronic Dietary Cancer 

Dietary 

Exposure 

(mg/kg/day) % aPAD 

Dietary 

Exposure 

(mg/kg/day) % cPAD 

Dietary 

Exposure 

(mg/kg/day) Risk 

General U.S. Population 

N/A N/A 

0.013145 26 

N/A N/A 

All Infants (< 1 year old) 0.011004 22 

Children 1-2 years old 0.021060 42 

Children 3-5 years old 0.019313 39 

Children 6-12 years old 0.012005 24 

Youth 13-19 years old 0.009525 19 

Adults 20-49 years old 0.013220 26 

Adults 50-99 years old 0.013149 26 

Females 13-49 years old 0.013039 26 

N/A = Not applicable. 

VIII. Characterization of Inputs/Outputs

This analysis is considered highly conservative dietary exposure assessment. An unrefined 

chronic dietary exposure analysis was performed for chronic exposure to mandipropamid using 

DEEM-FCIDTM. Tolerance-level residues for all commodities, except vegetable, tuberous and 

corm, subgroup 1C, DEEM (ver. 7.81) default processing factors (except grape, wine and sherry, 

1.5X) and 100% crop treated were assumed for this assessment. Further refinement to the 

analyses could be made through the use of anticipated residues, incorporation of percent crop 

treated information with mandipropamid, and/or monitoring data that better reflect residues at 

the time of consumption. Since risk estimates are below HED’s level of concern, a more highly 

refined analysis is not needed at this time. 

IX. Conclusions

Based on the conservative assumptions noted above, chronic dietary risk estimates for 

mandipropamid do not exceed HED’s level of concern for the general U.S. population, or any of 

the population subgroups, including those comprised of infants and children. 

X. List of Attachments: 

Attachment 1: Residue Input File for Chronic Analysis 

Attachment 2: Results of Chronic Dietary Exposure Analysis 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940 

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Attachment 1: Residue Input File for Chronic (Non-Cancer) Analysis

Filename: F:\Mandipropamid\Dietary\036602C_100615.R08 Chemical: Mandipropamid 

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day 

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 10-06-2015/17:13:24 Program ver. 3.16, 03-08-d 

----------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ ------- 

0101168000 1AB Ginseng, dried 0.300000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.115000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.115000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.115000 1.000 1.000 

0103082000 1CD Cassava 0.115000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.115000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.115000 1.000 1.000 

0103166000 1CD Ginger 0.115000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.115000 1.000 1.000 

0103167000 1CD Ginger, dried 0.115000 1.000 1.000 

0103296000 1C Potato, chips 0.115000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.115000 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.115000 6.500 1.000 

0103298000 1C Potato, flour 0.115000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 0.115000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 0.115000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.115000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.115000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.115000 1.000 1.000 

0103366000 1CD Sweet potato 0.115000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.115000 1.000 1.000 

0103371000 1CD Tanier, corm 0.115000 1.000 1.000 

0103387000 1CD Turmeric 0.115000 1.000 1.000 

0103406000 1CD Yam, true 0.115000 1.000 1.000 

0103407000 1CD Yam bean 0.115000 1.000 1.000 

0301165000 3A Garlic, bulb 0.050000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.050000 1.000 1.000 

0301237000 3A Onion, bulb 0.050000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.050000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.050000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.050000 9.000 1.000 

0301338000 3A Shallot, bulb 0.050000 1.000 1.000 

0302103000 3B Chive, fresh leaves 4.000000 1.000 1.000 

0302198000 3B Leek 4.000000 1.000 1.000 

0302239000 3B Onion, green 4.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 4.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 20.000000 1.000 1.000 

0401018000 4A Arugula 20.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 20.000000 1.000 1.000 

0401133000 4A Cress, garden 20.000000 1.000 1.000 

0401134000 4A Cress, upland 20.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 20.000000 1.000 1.000 

0401150000 4A Endive 20.000000 1.000 1.000 

0401204000 4A Lettuce, head 20.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 20.000000 1.000 1.000 

0401248000 4A Parsley, leaves 20.000000 1.000 1.000 

0401313000 4A Radicchio 20.000000 1.000 1.000 

0401355000 4A Spinach 20.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 20.000000 1.000 1.000 

0402076000 4B Cardoon 20.000000 1.000 1.000 

0402085000 4B Celery 20.000000 1.000 1.000 

0402085001 4B Celery-babyfood 20.000000 1.000 1.000 

0402086000 4B Celery, juice 20.000000 1.000 1.000 

0402087000 4B Celtuce 20.000000 1.000 1.000 

0402152000 4B Fennel, Florence 20.000000 1.000 1.000 

0402322000 4B Rhubarb 20.000000 1.000 1.000 

0402367000 4B Swiss chard 20.000000 1.000 1.000 

0501061000 5A Broccoli 3.000000 1.000 1.000 

0501061001 5A Broccoli-babyfood 3.000000 1.000 1.000 

0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 

0501064000 5A Brussels sprouts 3.000000 1.000 1.000 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940 

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0501069000 5A Cabbage 3.000000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 3.000000 1.000 1.000 

0501083000 5A Cauliflower 3.000000 1.000 1.000 

0501196000 5A Kohlrabi 3.000000 1.000 1.000 

0502063000 5B Broccoli raab 25.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 25.000000 1.000 1.000 

0502117000 5B Collards 25.000000 1.000 1.000 

0502194000 5B Kale 25.000000 1.000 1.000 

0502229000 5B Mustard greens 25.000000 1.000 1.000 

0502318000 5B Rape greens 25.000000 1.000 1.000 

0502389000 5B Turnip, greens 25.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.900000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.900000 1.000 1.000 

0801374000 8A Tomatillo 1.000000 1.000 1.000 

0801375000 8A Tomato 1.000000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 

0801376000 8A Tomato, paste 1.000000 5.400 1.000 Tomato 

 Full comment: Tomato processing study 

0801376001 8A Tomato, paste-babyfood 1.000000 5.400 1.000 ' 

0801377000 8A Tomato, puree 1.000000 3.300 1.000 ' 

0801377001 8A Tomato, puree-babyfood 1.000000 3.300 1.000 ' 

0801378000 8A Tomato, dried 1.000000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.000000 14.300 1.000 

0801379000 8A Tomato, juice 1.000000 1.500 1.000 

0801380000 8A Tomato, Tree 1.000000 1.000 1.000 

0802148000 8BC Eggplant 1.000000 1.000 1.000 

0802234000 8BC Okra 1.000000 1.000 1.000 

0802270000 8B Pepper, bell 1.000000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 

0901075000 9A Cantaloupe 0.600000 1.000 1.000 

0901187000 9A Honeydew melon 0.600000 1.000 1.000 

0901399000 9A Watermelon 0.600000 1.000 1.000 

0901400000 9A Watermelon, juice 0.600000 1.000 1.000 

0902021000 9B Balsam pear 0.600000 1.000 1.000 

0902088000 9B Chayote, fruit 0.600000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.600000 1.000 1.000 

0902135000 9B Cucumber 0.600000 1.000 1.000 

0902308000 9B Pumpkin 0.600000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.600000 1.000 1.000 

0902356000 9B Squash, summer 0.600000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.600000 1.000 1.000 

0902357000 9B Squash, winter 0.600000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.600000 1.000 1.000 

1100173500 11 Goji berry 1.000000 1.000 1.000 

1302174000 13B Gooseberry 1.400000 1.000 1.000 

1304175000 13D Grape 1.400000 1.000 1.000 

1304176000 13D Grape, juice 1.400000 1.200 1.000 

1304176001 13D Grape, juice-babyfood 1.400000 1.200 1.000 

1304179000 13D Grape, wine and sherry 1.400000 1.500 1.000 PF fro 

 Full comment: PF from grape processing study. 

1901028000 19A Basil, fresh leaves 30.000000 1.000 1.000 

1901028001 19A Basil, fresh leaves-babyfood 30.000000 1.000 1.000 

1901029000 19A Basil, dried leaves 240.000000 1.000 1.000 Sectio 

 Full comment: Section 18 

1901029001 19A Basil, dried leaves-babyfood 240.000000 1.000 1.000 Sectio 

 Full comment: Section 18 

8601000000 86A Water, direct, all sources 0.079000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.079000 1.000 1.000 

9500177000 O Grape, leaves 1.400000 1.000 1.000 

9500178000 O Grape, raisin 3.000000 1.000 1.000 Tolera 

 Full comment: Tolerance 

9500188000 O Hop 50.000000 1.000 1.000 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940 

Page 10 of 10 

Attachment 2: Results of Chronic Dietary Exposure Analysis 

US EPA Ver. 3.16, 03-08-d 

DEEM-FCID Chronic analysis for MANDIPROPAMID NHANES 2003-2008 2-day 

Residue file name: F:\Mandipropamid\Dietary\036602C_100615.R08 

 Adjustment factor #2 NOT used. 

Analysis Date 10-06-2015/17:14:40 Residue file dated: 10-06-2015/17:13:24 

Reference dose (RfD, Chronic) = .05 mg/kg bw/day 

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 Total exposure by population subgroup 

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 Total Exposure 

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 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

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Total US Population 0.013145 26.3% 

Hispanic 0.011675 23.4% 

Non-Hisp-White 0.013565 27.1% 

Non-Hisp-Black 0.011904 23.8% 

Non-Hisp-Other 0.014327 28.7% 

Nursing Infants 0.005519 11.0% 

Non-Nursing Infants 0.013453 26.9% 

Female 13+ PREG 0.011642 23.3% 

Children 1-6 0.019438 38.9% 

Children 7-12 0.011255 22.5% 

Male 13-19 0.009162 18.3% 

Female 13-19/NP 0.009887 19.8% 

Male 20+ 0.012452 24.9% 

Female 20+/NP 0.013912 27.8% 

Seniors 55+ 0.012941 25.9% 

All Infants 0.011004 22.0% 

Female 13-50 0.013021 26.0% 

Children 1-2 0.021060 42.1% 

Children 3-5 0.019313 38.6% 

Children 6-12 0.012005 24.0% 

Youth 13-19 0.009525 19.0% 

Adults 20-49 0.013220 26.4% 

Adults 50-99 0.013149 26.3% 

Female 13-49 0.013039 26.1% 

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