# Patent

## Title
Effects of inhibitors of FGFR3 on gene transcription

## Abstract

Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or adjustments may be made accordingly.

## Background
This application claims benefit of U.S. Provisional Application No. 60/748,944, filed Dec. 8, 2005, which in its entirety is herein incorporated by reference.


BACKGROUND OF THE INVENTION
The present invention relates generally to the field of pharmacogenomics and in particular to the use of biomarkers for identifying patients suitable for treatment as well as to methods of following their response to methods of treatment.
An effort to understand an individual patient's response or disease progression is the topic of present day research. Indeed, the field of pharmacogenomics or pharmacogenetics utilizes genomic data, pharmacology, and medicine, and often relies on advanced research tools to correlate genetic variability to one or more of predisposition to a disease and/or its progression, as well as therapeutic response to a drug or therapeutic regimen. Typically, multiple genes are analyzed simultaneously in a large-scale, genome-wide approach.
Proliferative cell disorders such as cancers usually develop through the accumulation of a series of mutations in the patient's DNA within a subpopulation of cells. These mutations may confer a survival advantage on the cells that causes them to grow and spread in an uncontrolled manner that is deleterious to the surrounding tissues. The particular set of mutations may be unique to an individual patient's tumor. Cancers of the same tissue or organ in different individuals may have originated from different sets of mutations, though certain mutations may be prevalent among particular cancer types. The characteristic set of mutations will determine how the cancer cells behave, and in particular, their likelihood of response to a given therapeutic regimen.
One may characterize the genetic alterations in a tumor by using advanced research tools that measure the genetic sequence of the tumor's DNA, or the RNA or proteins that are the expression of the altered DNA. It is a goal of current research to identify characteristics of an individual's tumor that are predictive of the likelihood of that tumor's response to various therapeutic treatments. Thus, one or more genes would be identified where presence of particular genetic mutations in the DNA, or their levels of expression, either as RNA transcripts or as proteins, or a combination of these factors, would be predictive of the likelihood that a particular treatment would affect the tumor in a manner that would be beneficial to the patient.
One main purpose is to determine which variations in individuals or subpopulations, associated with their genetics or the genetic characteristics of their disease, factor into drug efficacy and to create suitable tests, including diagnostic tests. Drugs that are tailored for patients with a particular genetic sequence, or for diseases characterized by particular genetic alterations, may thus be produced. The tests may also be used to guide treatment decisions, such as which drug or drug combination is mostly likely to be beneficial to the patient, and what dosing and schedule is most appropriate. Diagnostic tests and genetic profiling will help avoid the expense and the potentially detrimental trial-and-error approach to the suitability of a particular treatment regimen or a particular dosage level.
While the era of customized drugs may be coming, methods that utilize genetic information to identify specific individuals or subgroups for a particular type of treatment or optimization of a treatment may be immediately put to use today.
An individual's response to a particular treatment or predisposition to disease and the correlation to a particular gene of interest has been documented. It is now believed that cancer chemotherapy is limited by the predisposition of specific populations to drug toxicity or poor drug response. For a review of the use of germline polymorphisms in clinical oncology, see Lenz, H.-J. (2004) J. Clin. Oncol. 22(13):2519-2521. For a review of pharmacogenetic and pharmacogenomics in therapeutic antibody development for the treatment of cancer, see Yan and Beckman (2005) Biotechniques 39:565-568.
Results from numerous studies suggest several genes may play a major role in the principal pathways of cancer progression and recurrence, and that the corresponding germ-line polymorphisms may lead to significant differences at transcriptional and/or translational levels. Polymorphism has been linked to cancer susceptibility (oncogenes, tumor suppressor genes, and genes of enzymes involved in metabolic pathways) of individuals. In patients younger than 35 years, several markers for increased cancer risk have been identified. Cytochrome P4501A1 and gluthathione S-transferase M1 genotypes influence the risk of developing prostate cancer in younger patients. Similarly, mutations in the tumor suppressor gene, p53, are associated with brain tumors in young adults.
This approach may be extended to mutations that are specific to cancer cells, and not otherwise found in the patient's genome. For instance, it has been demonstrated clinically in patients with gastrointestinal stromal tumors (GIST) treated with the drug Gleevec (imatinib mesylate; Novartis) that particular activating mutations in the genes KIT and PDGFA are linked to higher response rates to the drug, see J Clin Oncol. 2003 Dec. 1; 21(23):4342-9.
By measuring changes in gene expression of cancer cell lines induced by treatment with a particular therapeutic agent, one may characterize the cells' response to that agent. This approach provides insight into the mechanism of the drug, including what biological processes or pathways it impacts. Such information can help guide the treatment of patients, by providing expectations as to which genes will change in response to treatment. An assay of those genes from a sample collected from a patient post-treatment could then be used to determine whether the drug was having the intended effect, and by extension, whether the dose or schedule should be altered, or the regimen discontinued. This approach would improve efficacy by ensuring that patients receive the most appropriate treatment.
SUMMARY OF THE INVENTION
One embodiment of the invention relates to a method of identifying a patient for treatment. The method may optionally include an administration of an FGFR3 inhibitor to the patient prior to measurement of gene expression on a sample obtained from the patient. The gene expression analysis is intended to detect the presence and/or alteration in level of expression of biomarkers disclosed herein. Notable detection or alteration in the levels compared to baseline levels is indicative of the candidacy of the patient for treatment.
Another embodiment of the invention comprises a method of monitoring response of a patient to treatment. The method may include the step of administration of an FGFR3 inhibitor to the patient prior to measurement of gene expression on a sample obtained from the patient. Alternatively, monitoring may be conducted on a sample obtained from a patient who has previously been treated so that an administration step by one practicing the method of monitoring response is not required. Detection of an alteration in the level of expression of at least one biomarker compared to baseline is indicative of a favorable response of the patient to the treatment.
Another aspect of the invention is a method of utilizing a biomarker in treatment of a patient. An FGFR3 inhibitor may be administered and gene expression level of one or more biomarkers tested. Thereafter, the same or a different inhibitor may be administered in the treatment.
Yet another aspect of the invention is a method of treatment for multiple myeloma. The method utilizes an agent that alters the level of expression of one or more of the identified biomarkers.
A method of adjusting a dosage amount of an inhibitor of FGFR3 for treatment of a cell proliferative disorder in a patient is also taught herein. The method comprises administering an initial amount of the inhibitor of FGFR3 to the patient, monitoring gene expression on a sample from the patient for at least one of the identified biomarkers and adjusting the dosage amount for subsequent administration to the patient, depending on the level of expression of the biomarker or biomarkers that has occurred upon administration of the initial amount.
A further embodiment of the invention is a method of utilizing a biomarker to identify an FGFR3 inhibitory compound for potential treatment or further development.


DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
The invention is an example of translational medicine at work, wherein patients may be treated selectively based on their particular genetic profile.
Definitions and Techniques
The practice of the present invention will employ, unless otherwise indicated, conventional techniques of immunology, molecular biology, microbiology, cell biology and recombinant DNA, which are within the skill of the art. See e.g., Sambrook, Fritsch and Maniatis, MOLECULAR CLONING: A LABORATORY MANUAL, 2nd edition (1989); CURRENT PROTOCOLS IN MOLECULAR BIOLOGY (F. M. Ausubel et al. eds., (1987)); the series METHODS IN ENZYMOLOGY (Academic Press, Inc.): PCR 2: A PRACTICAL APPROACH (M. J. MacPherson, B. D. Hames and G. R. Taylor eds. (1995)), Harlow and Lane, eds. (1988) ANTIBODIES, A LABORATORY MANUAL and ANIMAL CELL CULTURE (R. I. Freshney, ed. (1987)).
As used herein, certain terms have the following defined meanings.
As used in the specification and claims, the singular form “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a cell” includes a plurality of cells, including mixtures thereof.
All numerical designations, e.g., pH, temperature, time, concentration, and molecular weight, including ranges, are approximations which are varied (+) or (−) by increments of 0.1. It is to be understood, although not always explicitly stated that all numerical designations are preceded by the term “about”. It also is to be understood, although not always explicitly stated, that the reagents described herein are merely exemplary and that equivalents of such are known in the art.
The terms “polynucleotide” and “oligonucleotide” are used interchangeably and refer to a polymeric form of nucleotides of any length, either deoxyribonucleotides or ribonucleotides or analogs thereof. Polynucleotides can have any three-dimensional structure and may perform any function, known or unknown. The following are non-limiting examples of polynucleotides: a gene or gene fragment (for example, a probe, primer, EST or SAGE tag), exons, introns, messenger RNA (mRNA), transfer RNA, ribosomal RNA, ribozymes, cDNA, recombinant polynucleotides, branched polynucleotides, plasmids, vectors, isolated DNA of any sequence, isolated RNA of any sequence, nucleic acid probes, and primers. A polynucleotide can comprise modified nucleotides, such as methylated nucleotides and nucleotide analogs. If present, modifications to the nucleotide structure can be imparted before or after assembly of the polymer. The sequence of nucleotides can be interrupted by non-nucleotide components. A polynucleotide can be further modified after polymerization, such as by conjugation with a labeling component. The term also refers to both double- and single-stranded molecules. Unless otherwise specified or required, any embodiment of this invention that is a polynucleotide encompasses both the double-stranded form and each of two complementary single-stranded forms known or predicted to make up the double-stranded form.
A polynucleotide is composed of a specific sequence of four nucleotide bases: adenine (A); cytosine (C); guanine (G); thymine (T); and uracil (U) for guanine when the polynucleotide is RNA. Thus, the term “polynucleotide sequence” is the alphabetical representation of a polynucleotide molecule. This alphabetical representation can be input into databases in a computer having a central processing unit and used for bioinformatics applications such as functional genomics and homology searching.
A “gene” refers to a polynucleotide containing at least one open reading frame (ORF) that is capable of encoding a particular polypeptide or protein after being transcribed and translated. A polynucleotide sequence may be used to identify larger fragments or full-length coding sequences of the gene with which they are associated. Methods of isolating larger fragment sequences are known to those of skill in the art.
A “gene product” or alternatively a “gene expression product” refers to the amino acid (e.g., peptide or polypeptide) generated when a gene is transcribed and translated.
The term “polypeptide” is used interchangeably with the term “protein” and in its broadest sense refers to a compound of two or more subunit amino acids, amino acid analogs, or peptidomimetics. The subunits may be linked by peptide bonds. In another embodiment, the subunit may be linked by other bonds, e.g., ester, ether, etc.
As used herein the term “amino acid” refers to either natural and/or unnatural or synthetic amino acids, and both the D and L optical isomers, amino acid analogs, and peptidomimetics.
A peptide of three or more amino acids is commonly called an oligopeptide if the peptide chain is short. If the peptide chain is long, the peptide is commonly called a polypeptide or a protein.
As used herein, the term “comprising” is intended to mean that the methods include the recited elements, but do not exclude others. “Consisting essentially of” when used to define compositions and methods, shall mean excluding other elements of any essential significance to the combination. Thus, for example, a composition consisting essentially of elements as listed would not exclude trace contaminants from the isolation and purification method and pharmaceutically acceptable carriers, such as phosphate buffered saline, preservatives and the like. “Consisting of” shall mean excluding more than trace elements of other ingredients and substantial method steps of this invention. Embodiments defined by each of these transition terms are within the scope of this invention.
The term “isolated” means separated from constituents, cellular and otherwise, in which the polynucleotide, peptide, polypeptide, protein, antibody or fragment(s) thereof, are normally associated within nature. In one aspect of this invention, an isolated polynucleotide is separated from the 3′ and 5′ contiguous nucleotides with which it is normally associated within its native or natural environment, e.g., on the chromosome. As is apparent to those of skill in the art, a non-naturally occurring polynucleotide, peptide, polypeptide, protein, antibody, or fragment(s) thereof, does not require “isolation” to distinguish it from its naturally occurring counterpart. In addition, a “concentrated”, “separated” or “diluted” polynucleotide, peptide, polypeptide, protein, antibody or fragment(s) thereof, is distinguishable from its naturally occurring counterpart in that the concentration or number of molecules per volume is greater in a “concentrated” version or less than in a “separated” version than that of its naturally occurring counterpart. A polynucleotide, peptide, polypeptide, protein, antibody, or fragment(s) thereof, which differs from the naturally occurring counterpart in its primary sequence or, for example, by its glycosylation pattern, need not be present in its isolated form since it is distinguishable from its naturally occurring counterpart by its primary sequence or, alternatively, by another characteristic such as glycosylation pattern. Thus, a non-naturally occurring polynucleotide is provided as a separate embodiment from the isolated naturally occurring polynucleotide. A protein produced in a bacterial cell is provided as a separate embodiment from the naturally occurring protein isolated from a eukaryotic cell in which it is produced in nature.
A “probe” when used in the context of polynucleotide manipulation refers to an oligonucleotide that is provided as a reagent to detect a target potentially present in a sample of interest by hybridizing with the target. Usually, a probe will comprise a label or a means by which a label can be attached, either before or subsequent to the hybridization reaction. Suitable labels include, but are not limited to radioisotopes, fluorochromes, chemiluminescent compounds, dyes, and proteins, including enzymes.
A “primer” is a short polynucleotide, generally with a free 3′-OH group that binds to a target or “template” potentially present in a sample of interest by hybridizing with the target, and thereafter promoting polymerization of a polynucleotide complementary to the target. A “polymerase chain reactior” (“PCR”) is a reaction in which replicate copies are made of a target polynucleotide using a “pair of primers” or a “set of primers” consisting of an “upstream” and a “downstream” primer, and a catalyst of polymerization, such as a DNA polymerase, and typically a thermally-stable polymerase enzyme. Methods for PCR are well known in the art, and taught, for example in “PCR: A PRACTICAL APPROACH” (M. MacPherson et al, IRL Press at Oxford University Press (1991)). All processes of producing replicate copies of a polynucleotide, such as PCR or gene cloning, are collectively referred to herein as “replication.” A primer can also be used as a probe in hybridization reactions, such as Southern or Northern blot analyses. Sambrook et al., supra.
As used herein, “expression” refers to the process by which polynucleotides are transcribed into mRNA and/or the process by which the transcribed mRNA is subsequently translated into peptides, polypeptides or proteins. If the polynucleotide is derived from genomic DNA, expression may include splicing of the mRNA in a eukaryotic cell. “Differentially expressed” as applied to a gene, refers to the differential production of the mRNA transcribed and/or translated from the gene or the protein product encoded by the gene. A differentially expressed gene may be overexpressed or underexpressed as compared to the expression level of a normal or control cell. However, as used herein overpression generally is at least 1.25 fold or, alternatively, at least 1.5 fold or, alternatively, at least 2 fold expression, or alternatively, at least 4 fold expression over that detected in a normal or healthy counterpart cell or tissue. The term “differentially expressed” also refers to nucleotide sequences in a cell or tissue which are expressed where silent in a control cell or not expressed where expressed in a control cell.
A high expression level of the gene may occur because of over expression of the gene or an increase in gene copy number. The gene may also be translated into more protein because of deregulation of a negative regulator.
A “gene expression profile” refers to a pattern of expression of a set of genes that recurs in multiple samples and reflects a property shared by those samples, such as tissue type, response to a particular treatment, or activation of a particular biological process or pathway in the cells. Furthermore, a gene expression profile differentiates between samples that share that common property and those that do not with better accuracy than would likely be achieved by assigning the samples to the two groups at random. A gene expression profile may be used to predict whether samples of unknown status share that common property or not. Some variation between the levels of the individual genes of the set and the typical profile is to be expected, but the overall similarity of the expression levels to the typical profile is such that it is statistically unlikely that the similarity would be observed by chance in samples not sharing the common property that the expression profile reflects.
An expression “database” denotes a set of stored data that represent a collection of sequences, which in turn represent a collection of biological reference materials.
The term “cDNAs” refers to complementary DNA, i.e. mRNA molecules present in a cell or organism made into cDNA with an enzyme such as reverse transcriptase. A “cDNA library” is a collection of all of the mRNA molecules present in a cell or organism, all turned into cDNA molecules with the enzyme reverse transcriptase, then inserted into “vectors” (other DNA molecules that can continue to replicate after addition of foreign DNA). Exemplary vectors for libraries include bacteriophage (also known as “phage”), viruses that infect bacteria, for example, lambda phage. The library can then be probed for the specific cDNA (and thus mRNA) of interest.
As used herein, “solid phase support” or “solid support”, used interchangeably, is not limited to a specific type of support. Rather a large number of supports are available and are known to one of ordinary skill in the art. Solid phase supports include silica gels, resins, derivatized plastic films, glass beads, cotton, plastic beads, alumina gels, microarrays, and chips. As used herein, “solid support” also includes synthetic antigen-presenting matrices, cells, and liposomes. A suitable solid phase support may be selected on the basis of desired end use and suitability for various protocols. For example, for peptide synthesis, solid phase support may refer to resins such as polystyrene (e.g., PAM-resin obtained from Bachem Inc., Peninsula Laboratories, etc.), POLYHIPE® resin (obtained from Aminotech, Canada), polyamide resin (obtained from Peninsula Laboratories), polystyrene resin grafted with polyethylene glycol (TentaGel®, Rapp Polymere, Tubingen, Germany), or polydimethylacrylamide resin (obtained from Milligen/Bioscarch, California).
A polynucleotide also can be attached to a solid support for use in high throughput screening assays. PCT WO 97/10365, for example, discloses the construction of high density oligonucleotide chips. See also, U.S. Pat. Nos. 5,405,783; 5,412,087; and 5,445,934. Using this method, the probes are synthesized on a derivatized glass surface to form chip arrays. Photoprotected nucleoside phosphoramidites are coupled to the glass surface, selectively deprotected by photolysis through a photo litho graphic mask and reacted with a second protected nucleoside phosphoramidite. The coupling/deprotection process is repeated until the desired probe is complete.
As an example, transcriptional activity may be assessed by measuring levels of messenger RNA using a gene chip such as the Affymetrix HG-U133-Plus-2 GeneChips. High-throughput, real-time quanititation of RNA (of hundreds of genes simultaneously) thus becomes possible in a reproducible system.
“Hybridization” refers to a reaction in which one or more polynucleotides react to form a complex that is stabilized via hydrogen bonding between the bases of the nucleotide residues. The hydrogen bonding may occur by Watson-Crick base pairing, Hoogstein binding or in any other sequence-specific manner. The complex may comprise two strands forming a duplex structure, three or more strands forming a multi-stranded complex, a single self-hybridizing strand, or any combination of these. A hybridization reaction may constitute a step in a more extensive process, such as the initiation of a PCR reaction or the enzymatic cleavage of a polynucleotide by a ribozyme.
Hybridization reactions can be performed under conditions of different “stringency”. In general, a low stringency hybridization reaction is carried out at about 40° C. in 10×SSC or a solution of equivalent ionic strength/temperature. A moderate stringency hybridization is typically performed at about 50° C. in 6×SSC, and a high stringency hybridization reaction is generally performed at about 60° C. in 1×SSC.
When hybridization occurs in an antiparallel configuration between two single-stranded polynucleotides, the reaction is called “annealing” and those polynucleotides are described as “complementary”. A double-stranded polynucleotide can be “complementary” or “homologous” to another polynucleotide, if hybridization can occur between one of the strands of the first polynucleotide and the second. “Complementarity” or “homology” (the degree that one polynucleotide is complementary with another) is quantifiable in terms of the proportion of bases in opposing strands that are expected to form hydrogen bonding with each other, according to generally accepted base-pairing rules.
A polynucleotide or polynucleotide region (or a polypeptide or polypeptide region) has a certain percentage (for example, 80%, 85%, 90%, or 95%) of “sequence identity” to another sequence means that, when aligned, that percentage of bases (or amino acids) are the same in comparing the two sequences. This alignment and the percent homology or sequence identity can be determined using software programs known in the art, for example those described in CURRENT PROTOCOLS IN MOLECULAR BIOLOGY (F. M. Ausubel et al., eds., 1987) Supplement 30, section 7.7.18, Table 7.7.1. Preferably, default parameters are used for alignment. A preferred alignment program is BLAST, using default parameters. In particular, preferred programs are BLASTN and BLASTP, using the following default parameters: Genetic code=standard; filter=none; strand=both; cutoff 60; expect=10; Matrix=BLOSUM62; Descriptions=50 sequences; sort by=HIGH SCORE; Databases=non-redundant, GenBank+EMBL+DDBJ+PDB+GenBank CDS translations+SwissProtein+SPupdate+PIR. Details of these programs can be found at the following Internet address: www.ncbi.nlm.nih.gov/cgi-bin/BLAST.
The term “cell proliferative disorders” shall include dysregulation of normal physiological function characterized by abnormal cell growth and/or division or loss of function. Examples of “cell proliferative disorders” includes but is not limited to hyperplasia, neoplasia, metaplasia, and various autoimmune disorders, e.g., those characterized by the dysregulation of T cell apoptosis.
Hyperplasia is a form of controlled cell proliferation involving an increase in cell number in a tissue or organ, without significant alteration in structure or function. Metaplasia is a form of controlled cell growth in which one type of fully differentiated cell substitutes for another type of differentiated cell. Metaplasia can occur in epithelial or connective tissue cells. Atypical metaplasia involves a somewhat disorderly metaplastic epithelium.
As used herein, the terms “neoplastic cells,” “neoplastic disease,” “neoplasia,” “tumor,” “tumor cells,” “cancer,” and “cancer cells,” (used interchangeably) refer to cells which exhibit relatively autonomous growth, so that they exhibit an aberrant growth phenotype characterized by a significant loss of control of cell proliferation (i.e., dc-regulated cell division). Neoplastic cells can be malignant or benign. A metastatic cell or tissue means that the cell can invade and destroy neighboring body structures.
“Suppressing” tumor growth indicates a growth state that is curtailed when compared to growth without contact with educated, antigen-specific immune effector cells. Tumor cell growth can be assessed by any means known in the art, including, but not limited to, measuring tumor size, determining whether tumor cells are proliferating using a 3H-thymidine incorporation assay or counting tumor cells. “Suppressing” tumor cell growth means any or all of the following states: slowing, delaying and stopping tumor growth, as well as tumor shrinkage.
A “composition” is also intended to encompass a combination of active agent and another carrier, e.g., compound or composition, inert (for example, a detectable agent or label) or active, such as an adjuvant, diluent, binder, stabilizer, buffers, salts, lipophilic solvents, preservative, adjuvant or the like. Carriers also include pharmaceutical excipients and additives proteins, peptides, amino acids, lipids, and carbohydrates (e.g., sugars, including monosaccharides, di-, tri-, tetra-, and oligosaccharides; derivatized sugars such as alditols, aldonic acids, esterified sugars and the like; and polysaccharides or sugar polymers), which can be present singly or in combination, comprising alone or in combination 1-99.99% by weight or volume. Exemplary protein excipients include serum albumin such as human serum albumin (HSA), recombinant human albumin (rHA), gelatin, casein, and the like. Representative amino acid/antibody components, which can also function in a buffering capacity, include alanine, glycine, arginine, betaine, histidine, glutamic acid, aspartic acid, cysteine, lysine, leucine, isoleucine, valine, methionine, phenylalanine, aspartame, and the like. Carbohydrate excipients are also intended within the scope of this invention, examples of which include but are not limited to monosaccharides such as fructose, maltose, galactose, glucose, D-mannose, sorbose, and the like; disaccharides, such as lactose, sucrose, trehalose, cellobiose, and the like; polysaccharides, such as raffinose, melezitose, maltodextrins, dextrans, starches, and the like; and alditols, such as mannitol, xylitol, maltitol, lactitol, xylitol sorbitol (glucitol) and myoinositol.
The term carrier further includes a buffer or a pH adjusting agent; typically, the buffer is a salt prepared from an organic acid or base. Representative buffers include organic acid salts such as salts of citric acid, ascorbic acid, gluconic acid, carbonic acid, tartaric acid, succinic acid, acetic acid, or phthalic acid; Tris, tromethamine hydrochloride, or phosphate buffers. Additional carriers include polymeric excipients/additives such as polyvinylpyrrolidones, ficolls (a polymeric sugar), dextrates (e.g., cyclodextrins, such as 2-hydroxypropyl-.quadrature.-cyclodextrin), polyethylene glycols, flavoring agents, antimicrobial agents, sweeteners, antioxidants, antistatic agents, surfactants (e.g., polysorbates such as “TWEEN 20” and “TWEEN 80”), lipids (e.g., phospholipids, fatty acids), steroids (e.g., cholesterol), and chelating agents (e.g., EDTA).
As used herein, the term “pharmaceutically acceptable carrier” encompasses any of the standard pharmaceutical carriers, such as a phosphate buffered saline solution, water, and emulsions, such as an oil/water or water/oil emulsion, and various types of wetting agents.
The compositions also can include stabilizers and preservatives and any of the above noted carriers with the additional provisio that they be acceptable for use in vivo. For examples of carriers, stabilizers and adjuvants, see Martin REMINGTON'S PHARM. SCI., 15th Ed. (Mack Publ. Co., Easton (1975) and Williams & Williams, (1995), and in the “PHYSICIAN'S DESK REFERENCE”, 52nd ed., Medical Economics, Montvale, N.J. (1998).
An “effective amount” is an amount sufficient to effect beneficial or desired results. An effective amount can be administered in one or more administrations, applications or dosages.
A “subject,” “individual” or “patient” is used interchangeably herein, which refers to a vertebrate, preferably a mammal, more preferably a human. Mammals include, but are not limited to, murines, simians, humans, farm animals, sport animals, and pets.
“FGFR3” is the acronym for fibroblast growth factor receptor 3. The fibroblast growth factors are a family of polypeptide growth factors involved in a variety of activities, including mitogenesis, angiogenesis, and wound healing. They contain an extracellular domain with either 2 or 3 immunoglobulin (Ig)-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. FGFR3 was cloned by Keegan et al., PNAS, 88:1095-1099 (1991). Inhibition of activated FGFR3 in t(4; 14) multiple myeloma patients is thought to lead to apoptosis. Trudel, et al., Blood, 105(7):2941-2948 (2005); Grand, et al., Leukemia, 18:962-966 (2004).
An “inhibitor” of FGFR3 as used herein binds or blocks or diminishes the effect of the FGFR3. Examples include, but are not limited to CHIR-258 and related compounds, SU-5402, PD-173074, and siRNA.
A “biomarker” is a distinctive indicator or specific feature or characteristic of a biological process or event. As used herein, a biomarker is a gene. A biomarker may be especially useful for measuring the progress of a disease or the response to a given treatment. In addition to assessing prognosis, in some instances, it may be used to diagnose an illness or screen for patients within a category, such as those most likely to respond to a certain type of treatment. A biomarker may also be useful in guiding the development or administration of an agent for treatment of a disease.
As noted above, the invention provides methods of identifying patients suitable for treatment and methods of monitoring response in patients receiving treatment. Also provided are methods of treatment and methods of adjusting dosage amounts by utilizing the biomarkers disclosed herein. Methods of identifying the appropriate inhibitory compound are also within the scope of the invention.
The present invention also provides a screen for various agents and methods that may supplement or replace the anti-FGFR3 therapy known in the art. In one aspect, the agent, alone or in combination with another agent or therapy method, is provided to the patient. After administration, a sample from the patient is screened for expression of one or more biomarkers identified herein and then compared to a pre-determined baseline.
Kits containing an FGFR3 inhibitor and instructions necessary to perform a method of the invention also are within the scope of the invention.
Further details regarding the practice of the invention are discussed below.
Biomarkers
Panels of genes have now been identified, whose expression correlates with the inhibition of FGFR3. The presence or absence of gene expression or the level or amount of gene expression of one or more of the biomarkers identified herein may be used to guide treatment decisions and measure responsiveness of the patient to a given type of treatment. For example, detection of the presence or lack thereof of gene expression or alteration of the level of gene expression compared to a predetermined baseline of one or more of the biomarkers identified in Tables I-V provides information regarding whether a patient may be a suitable candidate for treatment by CHIR-258 or another FGFR3 inhibitor.
It should be noted that any or all of the following biomarkers may be of particular interest: CCL3, LOC150271, CD48, DUSP4, ITGB7, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A.
As is apparent to one of skill in the art, gene expression can be measured by detecting the presence or absence, or presence and/or absolute or relative quantity of a gene expression product (e.g., RNA, mRNA, or the protein or polypeptide transcript) or the alteration in gene copy number. In some embodiments, altered expression is likely the result of an increase in copy number. In alternative embodiment, altered expression is likely the result of the loss of function of another gene such as a tumor suppressor or other negative regulator. In yet a further embodiment, expression is altered by the “turning on” of an enhancer. Accordingly, the specific method used to detect altered expression, as compared to the control or baseline, may be different and dependent on the particular biomarker selected. In yet further embodiments, the method requires analysis of gene expression of one or more predetermined biomarkers by more than one method, e.g., by use of immunohistochemical and molecular techniques such as a gene chip or array.
Tables
Tables I through V are presented below and constitute an integral part of this disclosure.
Table I is a list of biomarkers whose expression is indicative of activity related to FGFR3 inhibition.
Table II is a preferred subset of Table I according to one aspect of the invention, listing biomarkers generally having a higher level of alteration of gene expression compared to baseline in response to FGFR3 inhibition.
Table III is more preferred subset of Table I according to one aspect of the invention, listing biomarkers generally having the highest level of alteration of gene expression compared to baseline in response to FGFR3 inhibition.
Table IV is a preferred subset of Table I according to a second aspect of the invention, listing biomarkers generally exhibiting the strongest correlation of gene expression in response to FGFR3 inhibition by the preferred compound, CHIR-258.
Table V is a more preferred subset of Table I according to a second aspect of the invention, listing biomarkers generally exhibiting the strongest correlation of gene expression in response to FGFR3 inhibition by the preferred compound, CHIR-258, in preference to either SU-5402 or PD-173074.
In each of Tables I through V, the biomarkers are shown with Entrez Gene ID Number (referring to the National Cancer Institute database identifier), Gene Symbol, and Gene Description.











TABLE I







ENTREZ





GENE



ID
GENE SYMBOL
GENE DESCRIPTION



















1.
6348
CCL3
chemokine (C-C motif) ligand 3


2.
200734
SPRED2
sprouty-related, EVH1 domain containing 2


3.
117854
TRIM6
tripartite motif-containing 6


4.
1846
DUSP4
dual specificity phosphatase 4


5.
894
CCND2
cyclin D2


6.
6241
RRM2
ribonucleotide reductase M2 polypeptide


7.
4821
NKX2-2
NK2 transcription factor related, locus 2 (Drosophila)


8.
3037
HAS2
hyaluronan synthase 2


9.
990
CDC6
CDC6 cell division cycle 6 homolog (S. cerevisiae)


10.
57405
SPBC25
spindle pole body component 25 homolog (S. cerevisiae)


11.
934
CD24
CD24 antigen (small cell lung carcinoma cluster 4





antigen)


12.
55165
C10orf3
chromosome 10 open reading frame 3


13.
55388
MCM10
MCM10 minichromosome maintenance deficient 10





(S. cerevisiae)


14.
79019
C22orf18
chromosome 22 open reading frame 18


15.
9768
KIAA0101
KIAA0101


16.
51659
Pfs2
DNA replication complex GINS protein PSF2


17.
4605
MYBL2
v-myb myeloblastosis viral oncogene homolog





(avian)-like 2


18.
161742
SPRED1
sprouty-related, EVH1 domain containing 1


19.
4175
MCM6
MCM6 minichromosome maintenance deficient 6





(MIS5 homolog, S. pombe) (S. cerevisiae)


20.
11130
ZWINT
ZW10 interactor


21.
26298
EHF
ets homologous factor


22.
7117
TMSL3
thymosin-like 3


23.
890
CCNA2
cyclin A2


24.
79075
DCC1
defective in sister chromatid cohesion homolog 1 (S. cerevisiae)


25.
83879
CDCA7
cell division cycle associated 7


26.
22873
DZIP1
DAZ interacting protein 1


27.
51514
DTL
denticleless homolog (Drosophila)


28.
55789
DEPDC1B
DEP domain containing 1B


29.
55355
DKFZp762E1312
hypothetical protein DKFZp762E1312


30.
10052
GJA7
gap junction protein, alpha 7, 45 kDa (connexin 45)


31.
146909
LOC146909
hypothetical protein LOC146909


32.
113130
CDCA5
cell division cycle associated 5


33.
1017
CDK2
cyclin-dependent kinase 2


34.
4176
MCM7
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)


35.
81610
C20orf129
chromosome 20 open reading frame 129


36.
9833
MELK
maternal embryonic leucine zipper kinase


37.
29128
UHRF1
ubiquitin-like, containing PHD and RING finger





domains, 1


38.
4171
MCM2
MCM2 minichromosome maintenance deficient 2,





mitotin (S. cerevisiae)


39.
79801
SHCBP1
SHC SH2-domain binding protein 1


40.
28231
SLCO4A1
solute carrier organic anion transporter family,





member 4A1


41.
113115
FAM54A
family with sequence similarity 54, member A


42.
22974
TPX2
TPX2, microtubule-associated protein homolog





(Xenopus laevis)


43.
9232
PTTG1
pituitary tumor-transforming 1


44.
137392
LOC137392
similar to CG6405 gene product


45.
195828
ZNF367
zinc finger protein 367


46.
4288
MKI67
antigen identified by monoclonal antibody Ki-67


47.
701
BUB1B
BUB1 budding uninhibited by benzimidazoles 1





homolog beta (yeast)


48.
9928
KIF14
kinesin family member 14


49.
3832
KIF11
kinesin family member 11


50.
11065
UBE2C
ubiquitin-conjugating enzyme E2C


51.
9837
PSF1
DNA replication complex GINS protein PSF1


52.
387103
C6orf173
chromosome 6 open reading frame 173


53.
1870
E2F2
E2F transcription factor 2


54.
79733
E2F8
E2F transcription factor 8


55.
991
CDC20
CDC20 cell division cycle 20 homolog (S. cerevisiae)


56.
3014
H2AFX
H2A histone family, member X


57.
10112
KIF20A
kinesin family member 20A


58.
993
CDC25A
cell division cycle 25A


59.
24137
KIF4A
kinesin family member 4A


60.
80144
FRAS1
Fraser syndrome 1


61.
55010
FLJ20641
hypothetical protein FLJ20641


62.
9319
TRIP13
thyroid hormone receptor interactor 13


63.
9355
LHX2
LIM homeobox 2


64.
7153
TOP2A
topoisomerase (DNA) II alpha 170 kDa


65.
4174
MCM5
MCM5 minichromosome maintenance deficient 5,





cell division cycle 46 (S. cerevisiae)


66.
55215
FLJ10719
hypothetical protein FLJ10719


67.
11013
TMSL8
thymosin-like 8


68.
5983
RFC3
replication factor C (activator 1) 3, 38 kDa


69.
1063
CENPF
centromere protein F, 350/400ka (mitosin)


70.
3683
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte





function-associated antigen 1; alpha polypeptide)


71.
2237
FEN1
flap structure-specific endonuclease 1


72.
27338
UBE2S
ubiquitin-conjugating enzyme E2S


73.
4001
LMNB1
lamin B1


74.
29089
UBE2T
ubiquitin-conjugating enzyme E2T (putative)


75.
55839
BM039
uncharacterized bone marrow protein BM039


76.
2115
ETV1
ets variant gene 1


77.
440279
UNC13C
unc-13 homolog C (C. elegans)


78.
962
CD48
CD48 antigen (B-cell membrane protein)


79.
54910
SEMA4C
sema domain, immunoglobulin domain (Ig),





transmembrane domain (TM) and short cytoplasmic





domain, (semaphorin) 4C


80.
1902
EDG2
endothelial differentiation, lysophosphatidic acid G-





protein-coupled receptor, 2


81.
64946
CENPH
centromere protein H


82.
157570
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)


83.
389835
FAM72A
family with sequence similarity 72, member A


84.
144455
E2F7
E2F transcription factor 7


85.
51512
GTSE1
G-2 and S-phase expressed 1


86.
7298
TYMS
thymidylate synthetase


87.
7374
UNG
uracil-DNA glycosylase


88.
5578
PRKCA
protein kinase C, alpha


89.
672
BRCA1
breast cancer 1, early onset


90.
84952
CGNL1
cingulin-like 1


91.
10252
SPRY1
sprouty homolog 1, antagonist of FGF signaling





(Drosophila)


92.
79682
MLF1IP
MLF1 interacting protein


93.
8851
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1





(p35)


94.
10635
RAD51AP1
RAD51 associated protein 1


95.
22998
KIAA1102
KIAA1102 protein


96.
148203
LOC148203
hypothetical protein LOC148203


97.
7465
WEE1
WEE1 homolog (S. pombe)


98.
83540
CDCA1
cell division cycle associated 1


99.
3070
HELLS
helicase, lymphoid-specific


100.
891
CCNB1
cyclin B1


101.
6790
STK6
serine/threonine kinase 6


102.
56992
KIF15
kinesin family member 15


103.
7112
TMPO
thymopoietin


104.
63901
FLJ22794
FLJ22794 protein


105.
9493
KIF23
kinesin family member 23


106.
9133
CCNB2
cyclin B2


107.
4173
MCM4
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)


108.
7083
TK1
thymidine kinase 1, soluble


109.
983
CDC2
cell division cycle 2, G1 to S and G2 to M


110.
11339
OIP5
Opa interacting protein 5


111.
51203
NUSAP1
nucleolar and spindle associated protein 1


112.
5111
PCNA
proliferating cell nuclear antigen


113.
11004
KIF2C
kinesin family member 2C


114.
54443
ANLN
anillin, actin binding protein (scraps homolog,





Drosophila)


115.
83461
CDCA3
cell division cycle associated 3


116.
4085
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)


117.
9201
DCAMKL1
doublecortin and CaM kinase-like 1


118.
1111
CHEK1
CHK1 checkpoint homolog (S. pombe)


119.
9055
PRC1
protein regulator of cytokinesis 1


120.
7804
LRP8
low density lipoprotein receptor-related protein 8,





apolipoprotein e receptor


121.
4915
NTRK2
neurotrophic tyrosine kinase, receptor, type 2


122.
28951
TRIB2
tribbles homolog 2 (Drosophila)


123.
4281
MID1
midline 1 (Opitz/BBB syndrome)


124.
3148
HMGB2
high-mobility group box 2


125.
3161
HMMR
hyaluronan-mediated motility receptor (RHAMM)


126.
10276
NET1
neuroepithelial cell transforming gene 1


127.
29028
ATAD2
ATPase family, AAA domain containing 2


128.
1062
CENPE
centromere protein E, 312 kDa


129.
1491
CTH
cystathionase (cystathionine gamma-lyase)


130.
10615
SPAG5
sperm associated antigen 5


131.
64581
CLEC7A
C-type lectin domain family 7, member A


132.
10592
SMC2L1
SMC2 structural maintenance of chromosomes 2-





like 1 (yeast)


133.
332
BIRC5
baculoviral IAP repeat-containing 5 (survivin)


134.
4172
MCM3
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)


135.
64105
FKSG14
leucine zipper protein FKSG14


136.
64151
HCAP-G
chromosome condensation protein G


137.
1163
CKS1B
CDC28 protein kinase regulatory subunit 1B


138.
122769
PPIL5
peptidylprolyl isomerase (cyclophilin)-like 5


139.
3398
ID2
inhibitor of DNA binding 2, dominant negative helix-





loop-helix protein


140.
22822
PHLDA1
pleckstrin homology-like domain, family A, member 1


141.
1718
DHCR24
24-dehydrocholesterol reductase


142.
145482
ZADH1
zinc binding alcohol dehydrogenase, domain





containing 1


143.
1847
DUSP5
dual specificity phosphatase 5


144.
26271
FBXO5
F-box protein 5


145.
9212
AURKB
aurora kinase B


146.
29968
PSAT1
phosphoserine aminotransferase 1


147.
26147
PHF19
PHD finger protein 19


148.
55635
DEPDC1
DEP domain containing 1


149.
10403
KNTC2
kinetochore associated 2


150.
64081
MAWBP
MAWD binding protein


151.
84858
ZNF503
zinc finger protein 503


152.
55723
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)


153.
7272
TTK
TTK protein kinase


154.
9535
GMFG
glia maturation factor, gamma


155.
1058
CENPA
centromere protein A, 17 kDa


156.
84515
MCM8
MCM8 minichromosome maintenance deficient 8 (S. cerevisiae)


157.
54069
C21orf45
chromosome 21 open reading frame 45


158.
5984
RFC4
replication factor C (activator 1) 4, 37 kDa


159.
389831
LOC389831
hypothetical gene supported by AL713796


160.
157313
CDCA2
cell division cycle associated 2


161.
29127
RACGAP1
Rac GTPase activating protein 1


162.
55872
PBK
PDZ binding kinase


163.
4678
NASP
nuclear autoantigenic sperm protein (histone-





binding)


164.
7171
TPM4
tropomyosin 4


165.
7443
VRK1
vaccinia related kinase 1


166.
699
BUB1
BUB1 budding uninhibited by benzimidazoles 1





homolog (yeast)


167.
3925
STMN1
stathmin 1/oncoprotein 18


168.
865
CBFB
core-binding factor, beta subunit


169.
399664
RKHD1
ring finger and KH domain containing 1


170.
11168
PSIP1
PC4 and SFRS1 interacting protein 1


171.
84057
GAJ
GAJ protein


172.
57082
CASC5
cancer susceptibility candidate 5


173.
23286
KIBRA
KIBRA protein


174.
285513
LOC285513
hypothetical protein LOC285513


175.
259266
ASPM
asp (abnormal spindle)-like, microcephaly





associated (Drosophila)


176.
150468
FLJ40629
hypothetical protein FLJ40629


177.
6659
SOX4
SRY (sex determining region Y)-box 4


178.
51053
GMNN
geminin, DNA replication inhibitor


179.
3159
HMGA1
high mobility group AT-hook 1


180.
81620
CDT1
DNA replication factor


181.
11332
BACH
brain acyl-CoA hydrolase


182.
4751
NEK2
NIMA (never in mitosis gene a)-related kinase 2


183.
1033
CDKN3
cyclin-dependent kinase inhibitor 3 (CDK2-





associated dual specificity phosphatase)


184.
8864
PER2
period homolog 2 (Drosophila)


185.
3418
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial


186.
63979
FIGNL1
fidgetin-like 1


187.
55646
LYAR
hypothetical protein FLJ20425


188.
91614
LOC91614
novel 58.3 KDA protein


189.
8630
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6


190.
1038
CDR1
cerebellar degeneration-related protein 1, 34 kDa


191.
6941
TCF19
transcription factor 19 (SC1)


192.
256435
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-





1,3)-N-acetylgalactosaminide alpha-2,6-





sialyltransferase 3


193.
54892
LUZP5
leucine zipper protein 5


194.
4603
MYBL1
v-myb myeloblastosis viral oncogene homolog





(avian)-like 1


195.
1719
DHFR
dihydrofolate reductase


196.
170954
KIAA1949
KIAA1949


197.
7903
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-





sialyltransferase 4


198.
9787
DLG7
discs, large homolog 7 (Drosophila)


199.
56935
FN5
FN5 protein


200.
3015
H2AFZ
H2A histone family, member Z


201.
10189
THOC4
THO complex 4


202.
494143
LOC494143
similar to RIKEN cDNA 2510006C20 gene


203.
6240
RRM1
ribonucleotide reductase M1 polypeptide


204.
1894
ECT2
epithelial cell transforming sequence 2 oncogene


205.
7913
DEK
DEK oncogene (DNA binding)


206.
2146
EZH2
enhancer of zeste homolog 2 (Drosophila)


207.
55055
FLJ10036
Zwilch


208.
11073
TOPBP1
topoisomerase (DNA) II binding protein 1


209.
55502
HES6
hairy and enhancer of split 6 (Drosophila)


210.
55247
NEIL3
nei endonuclease VIII-like 3 (E. coli)


211.
54885
FLJ20298
FLJ20298 protein


212.
83641
C10orf45
chromosome 10 open reading frame 45


213.
64919
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)


214.
26095
PTPN20
protein tyrosine phosphatase, non-receptor type 20


215.
23590
TPRT
trans-prenyltransferase


216.
387882
LOC387882
hypothetical protein


217.
51232
CRIM1
cysteine-rich motor neuron 1


218.
801
CALM1
calmodulin 1 (phosphorylase kinase, delta)


219.
55964
SEPT3
septin 3


220.
493861
EID3
E1A-like inhibitor of differentiation 3


221.
29980
DONSON
downstream neighbor of SON


222.
147138
EVER2
epidermodysplasia verruciformis 2


223.
80150
ASRGL1
asparaginase like 1


224.
5985
RFC5
replication factor C (activator 1) 5, 36.5 kDa


225.
51155
HN1
hematological and neurological expressed 1


226.
7004
TEAD4
TEA domain family member 4


227.
4325
MMP16
matrix metalloproteinase 16 (membrane-inserted)


228.
203068
TUBB
tubulin, beta polypeptide


229.
4602
MYB
v-myb myeloblastosis viral oncogene homolog





(avian)


230.
55706
TMEM48
transmembrane protein 48


231.
348235
FAM33A
family with sequence similarity 33, member A


232.
8871
SYNJ2
synaptojanin 2


233.
81563
C1orf21
chromosome 1 open reading frame 21


234.
51192
CKLF
chemokine-like factor


235.
2326
FMO1
flavin containing monooxygenase 1


236.
91057
NY-REN-41
NY-REN-41 antigen


237.
10376
K-ALPHA-1
tubulin, alpha, ubiquitous


238.
23234
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9


239.
5982
RFC2
replication factor C (activator 1) 2, 40 kDa


240.
51063
FAM26B
family with sequence similarity 26, member B


241.
9953
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase





3B1


242.
79723
SUV39H2
suppressor of variegation 3-9 homolog 2





(Drosophila)


243.
79596
C13orf7
chromosome 13 open reading frame 7


244.
23165
NUP205
nucleoporin 205 kDa


245.
9530
BAG4
BCL2-associated athanogene 4


246.
3146
HMGB1
high-mobility group box 1


247.
445815
PALM2-AKAP2
PALM2-AKAP2 protein


248.
5557
PRIM1
primase, polypeptide 1, 49 kDa


249.
2983
GUCY1B3
guanylate cyclase 1, soluble, beta 3


250.
51776
ZAK
sterile alpha motif and leucine zipper containing





kinase AZK


251.
10926
ASK
activator of S phase kinase


252.
8833
GMPS
guanine monphosphate synthetase


253.
84930
MASTL
microtubule associated serine/threonine kinase-like


254.
90417
C15orf23
chromosome 15 open reading frame 23


255.
8530
CST7
cystatin F (leukocystatin)


256.
9532
BAG2
BCL2-associated athanogene 2


257.
23310
hCAP-D3
KIAA0056 protein


258.
283991
MGC29814
hypothetical protein MGC29814


259.
91607
FLJ34922
hypothetical protein FLJ34922


260.
7398
USP1
ubiquitin specific protease 1


261.
2669
GEM
GTP binding protein overexpressed in skeletal





muscle


262.
151246
SGOL2
shugoshin-like 2 (S. pombe)


263.
23421
ITGB3BP
integrin beta 3 binding protein (beta3-endonexin)


264.
84969
C20orf100
chromosome 20 open reading frame 100


265.
201725
LOC201725
hypothetical protein LOC201725


266.
5361
PLXNA1
plexin A1


267.
3708
ITPR1
inositol 1,4,5-triphosphate receptor, type 1


268.
55740
ENAH
enabled homolog (Drosophila)


269.
126731
C1orf96
chromosome 1 open reading frame 96


270.
57037
ANKMY2
ankyrin repeat and MYND domain containing 2


271.
23331
KIAA1043
KIAA1043 protein


272.
3930
LBR
lamin B receptor


273.
3838
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha





1)


274.
1230
CCR1
chemokine (C-C motif) receptor 1


275.
2200
FBN1
fibrillin 1 (Marfan syndrome)


276.
6867
TACC1
transforming, acidic coiled-coil containing protein 1


277.
27115
PDE7B
phosphodiesterase 7B


278.
11151
CORO1A
coronin, actin binding protein, 1A


279.
6385
SDC4
syndecan 4 (amphiglycan, ryudocan)


280.
3182
HNRPAB
heterogeneous nuclear ribonucleoprotein A/B


281.
5757
PTMA
prothymosin, alpha (gene sequence 28)


282.
83990
BRIP1
BRCA1 interacting protein C-terminal helicase 1


283.
9830
TRIM14
tripartite motif-containing 14


284.
57761
TRIB3
tribbles homolog 3 (Drosophila)


285.
2026
ENO2
enolase 2 (gamma, neuronal)


286.
8727
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1


287.
5880
RAC2
ras-related C3 botulinum toxin substrate 2 (rho





family, small GTP bindin protein Rac2)


288.
864
RUNX3
runt-related transcription factor 3


289.
10950
BTG3
BTG family, member 3


290.
81539
SLC38A1
solute carrier family 38, member 1


291.
26051
PPP1R16B
protein phosphatase 1, regulatory (inhibitor) subunit





16B


292.
5793
PTPRG
protein tyrosine phosphatase, receptor type, G


293.
2767
GNA11
guanine nucleotide binding protein (G protein), alpha





11 (Gq class)


294.
55013
FLJ20647
hypothetical protein FLJ20647


295.
4885
NPTX2
neuronal pentraxin II


296.
79710
MORC4
MORC family CW-type zinc finger 4


297.
490
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1


298.
2956
MSH6
mutS homolog 6 (E. coli)


299.
6611
SMS
spermine synthase


300.
6627
SNRPA1
small nuclear ribonucleoprotein polypeptide A1


301.
1434
CSE1L
CSE1 chromosome segregation 1-like (yeast)


302.
7371
UCK2
uridine-cytidine kinase 2


303.
7277
TUBA1
tubulin, alpha 1 (testis specific)


304.
1786
DNMT1
DNA (cytosine-5-)-methyltransferase 1


305.
54801
FAM29A
family with sequence similarity 29, member A


306.
54908
FLJ20364
hypothetical protein FLJ20364


307.
119467
MGC32871
hypothetical protein MGC32871


308.
90390
THRAP6
thyroid hormone receptor associated protein 6


309.
60468
BACH2
BTB and CNC homology 1, basic leucine zipper





transcription factor 2


310.
6510
SLC1A5
solute carrier family 1 (neutral amino acid





transporter), member 5


311.
6628
SNRPB
small nuclear ribonucleoprotein polypeptides B and





B1


312.
205
AK3L1
adenylate kinase 3-like 1


313.
116832
RPL39L
ribosomal protein L39-like


314.
79902
PCNT1
pericentrin 1


315.
54962
FLJ20516
timeless-interacting protein


316.
23279
NUP160
nucleoporin 160 kDa


317.
23046
KIF21B
kinesin family member 21B


318.
2288
FKBP4
FK506 binding protein 4, 59 kDa


319.
5698
PSMB9
proteasome (prosome, macropain) subunit, beta





type, 9 (large multifunctional protease 2)


320.
10160
FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain





protein 1 (chondrocyte-derived)


321.
8502
PKP4
plakophilin 4


322.
10675
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)


323.
29899
GPSM2
G-protein signalling modulator 2 (AGS3-like, C. elegans)


324.
10602
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3


325.
8243
SMC1L1
SMC1 structural maintenance of chromosomes 1-





like 1 (yeast)


326.
6347
CCL2
chemokine (C-C motif) ligand 2


327.
5932
RBBP8
retinoblastoma binding protein 8


328.
6877
TAF5
TAF5 RNA polymerase II, TATA box binding protein





(TBP)-associated factor, 100 kDa


329.
10801
SEPT9
septin 9


330.
55536
CDCA7L
cell division cycle associated 7-like


331.
11340
EXOSC8
exosome component 8


332.
5873
RAB27A
RAB27A, member RAS oncogene family


333.
53354
PANK1
pantothenate kinase 1


334.
2534
FYN
FYN oncogene related to SRC, FGR, YES


335.
55166
C6orf139
chromosome 6 open reading frame 139


336.
27346
MAC30
hypothetical protein MAC30


337.
79037
MGC2463
hypothetical protein MGC2463


338.
116496
C1orf24
chromosome 1 open reading frame 24


339.
84314
MGC10744
hypothetical protein MGC10744


340.
23531
MMD
monocyte to macrophage differentiation-associated


341.
6558
SLC12A2
solute carrier family 12 (sodium/potassium/chloride





transporters), member 2


342.
64282
PAPD5
PAP associated domain containing 5


343.
55636
CHD7
chromodomain helicase DNA binding protein 7


344.
55026
FLJ20716
hypothetical protein FLJ20716


345.
22929
SEPHS1
selenophosphate synthetase 1


346.
10541
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32





family, member B


347.
79621
FLJ11712
hypothetical protein FLJ11712


348.
6432
SFRS7
splicing factor, arginine/serine-rich 7, 35 kDa


349.
5214
PFKP
phosphofructokinase, platelet


350.
26031
OSBPL3
oxysterol binding protein-like 3


351.
1102
RCBTB2
regulator or chromosome condensation (RCC1) and





BTB (POZ) domain containing protein 2


352.
6929
TCF3
transcription factor 3 (E2A immunoglobulin enhancer





binding factors E12/E47)


353.
6632
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide





16 kDa


354.
2047
EPHB1
EPH receptor B1


355.
5168
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase





2 (autotaxin)


356.
55257
C20orf20
chromosome 20 open reading frame 20


357.
81611
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32





family, member E


358.
23246
BOP1
block of proliferation 1


359.
23526
HA-1
minor histocompatibility antigen HA-1


360.
84250
ANKRD32
ankyrin repeat domain 32


361.
6999
TDO2
tryptophan 2,3-dioxygenase


362.
8317
CDC7
CDC7 cell division cycle 7 (S. cerevisiae)


363.
55752
SEPT11
spetin 11


364.
39
ACAT2
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl





Coenzyme A thiolase)


365.
54830
FLJ20130
hypothetical protein FLJ20130


366.
83732
RIOK1
RIO kinase 1 (yeast)


367.
10808
HSPH1
heat shock 105 kDa/110 kDa protein 1


368.
489
ATP2A3
ATPase, Ca++ transporting, ubiquitous


369.
3251
HPRT1
hypoxanthine phosphoribosyltransferase 1 (Lesch-





Nyhan syndrome)


370.
10051
SMC4L1
SMC4 structural maintenance of chromosomes 4-





like 1 (yeast)


371.
55816
DOK5
docking protein 5


372.
3676
ITGA4
intergin, alpha 4 (antigen CD49D, alpha 4 subunit of





VLA-4 receptor)


373.
8819
SAP30
sin3-associated polypeptide, 30 kDa


374.
4436
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1





(E. coli)


375.
10212
DDX39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39


376.
5889
RAD51C
RAD51 homolog C (S. cerevisiae)


377.
134111
FLJ25076
similar to CG4502-PA


378.
51377
UCHL5
ubiquitin carboxyl-terminal hydrolase L5


379.
6657
SOX2
SRY (sex determining region Y)-box 2


380.
241
ALOX5AP
arachidonate 5-lipoxygenase-activating protein


381.
79888
FLJ12443
hypothetical protein FLJ12443


382.
1368
CPM
carboxypeptidase M


383.
397
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta


384.
3336
HSPE1
heat shock 10 kDa protein 1 (chaperonin 10)


385.
2104
ESRRG
estrogen-related receptor gamma


386.
2171
FABP5
fatty acid binding protein 5 (psoriasis-associated)


387.
6574
SLC20A1
solute carrier family 20 (phosphate transporter),





member 1


388.
2743
GLRB
glycine receptor, beta


389.
1019
CDK4
cyclin-dependent kinase 4


390.
9295
SFRS11
splicing factor, arginine/serine-rich 11


391.
56952
PRTFDC1
phosphoribosyl transferase domain containing 1


392.
6472
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)


393.
23512
SUZ12
suppressor of zeste 12 homolog (Drosophila)


394.
586
BCAT1
branched chain aminotransferase 1, cytosolic


395.
8836
GGH
gamma-glutamyl hydrolase (conjugase,





folylpolygammaglutamyl hydrolase)


396.
10383
TUBB2
tubulin, beta, 2


397.
54101
RIPK4
receptor-interacting serine-threonine kinase 4


398.
130271
PLEKHH2
pleckstrin homology domain containing, family H





(with MyTH4 domain) member 2


399.
129401
NUP35
nucleoporin 35 kDa


400.
10128
LRPPRC
leucine-rich PPR-motif containing


401.
51703
ACSL5
acyl-CoA synthetase long-chain family member 5


402.
9448
MAP4K4
mitogen-activated protein kinase kinase kinase





kinase 4


403.
79017
C7orf24
chromosome 7 open reading frame 24


404.
262
AMD1
adenosylmethionine decarboxylase 1


405.
960
CD44
CD44 antigen (homing function and Indian blood





group system)


406.
81930
KIF18A
kinesin family member 18A


407.
64116
SLC39A8
solute carrier family 39 (zinc transporter), member 8


408.
26586
CKAP2
cytoskeleton associated protein 2


409.
51144
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12


410.
51002
CGI-121
CGI-121 protein


411.
9126
CSPG6
chondroitin sulfate proteoglycan 6 (bamacan)


412.
79154
MGC4172
short-chain dehydrogenase/reductase


413.
11096
ADAMTS5
a disintegrin-like and metalloprotease (reprolysin





type) with thrombospondin type 1 mofit, 5





(aggrecanase-2)


414.
84803
MGC11324
hypothetical protein MGC11324


415.
4082
MARCKS
myristoylated alanine-rich protein kinase C substrate


416.
4086
SMAD1
SMAD, mothers against DPP homolog 1





(Drosophila)


417.
9446
GSTO1
glutathione S-transferase omega 1


418.
23636
NUP62
nucleoporin 62 kDa


419.
81839
VANGL1
vang-like 1 (van gogh, Drosophila)


420.
3149
HMGB3
high-mobility group box 3


421.
79023
NUP37
nucleoporin 37 kDa


422.
10606
PAICS
phosphoribosylaminoimidazole carboxylase,





phosphoribosylaminoimidazole succinocarboxamide





synthetase


423.
10492
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting





protein


424.
3320
HSPCA
heat shock 90 kDa protein 1, alpha


425.
6119
RPA3
replication protein A3, 14 kDa


426.
55352
HSA272196
hypothetical protein, clone 2746033


427.
9759
HDAC4
histone deacetylase 4


428.
5725
PTBP1
polypyrimidine tract binding protein 1


429.
2119
ETV5
ets variant gene 5 (ets-related molecule)


430.
10019
LNK
lymphocyte adaptor protein


431.
9734
HDAC9
histone deacetylase 9


432.
5885
RAD21
RAD21 homolog (S. pombe)


433.
79930
DOK3
docking protein 3


434.
22837
COBLL1
COBL-like 1


435.
339448
LOC339448
hypothetical protein LOC339448


436.
11051
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type





motif 21


437.
9735
KNTC1
kinetochore associated 1


438.
4148
MATN3
matrilin 3


439.
4200
ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial


440.
26084
SGEF
Src homology 3 domain-containing guanine





nucleotide exchange factor


441.
27101
CACYBP
calcyclin binding protein


442.
23012
STK38L
serine/threonine kinase 38 like


443.
54566
EPB41L4B
erythrocyte membrane protein band 4.1 like 4B


444.
6566
SLC16A1
solute carrier family 16 (monocarboxylic acid





transporters), member 1


445.
54947
FLJ20481
hypothetical protein FLJ20481


446.
255488
IBRDC2
IBR domain containing 2


447.
2289
FKBP5
FK506 binding protein 5


448.
5036
PA2G4
proliferation-associated 2G4, 38 kDa


449.
4869
NPM1
nucleophosmin (nucleolar phosphoprotein B23,





numatrin)


450.
10384
BTN3A3
butyrophilin, subfamily 3, member A3


451.
10785
WDR4
WD repeat domain 4


452.
3099
HK2
hexokinase 2


453.
56121
PCDHB15
protocadherin beta 15


454.
10155
TRIM28
tripartite motif-containing 28


455.
6340
SCNN1G
sodium channel, nonvoltage-gated 1, gamma


456.
25804
LSM4
LSM4 homolog, U6 small nuclear RNA associated





(S. cerevisiae)


457.
3939
LDHA
lactate dehydrogenase A


458.
57552
AADACL1
arylacetamide deacetylase-like 1


459.
9184
BUB3
BUB3 budding uninhibited by benzimidazoles 3





homolog (yeast)


460.
657
BMPR1A
bone morphogenetic protein receptor, type IA


461.
5631
PRPS1
phosphoribosyl pyrophosphate synthetase 1


462.
204
AK2
adenylate kinase 2


463.
55270
NUDT15
nudix (nucleoside diphosphate linked moiety X)-type





motif 15


464.
10265
IRX5
iroquois homeobox protein 5


465.
4640
MYO1A
myosin IA


466.
79180
EFHD2
EF hand domain family, member D2


467.
4076
M11S1
membrane component, chromosome 11, surface





marker 1


468.
55276
PGM2
phosphoglucomutase 2


469.
83857
ARG99
ARG99 protein


470.
116448
OLIG1
oligodendrocyte transcription factor 1


471.
5696
PSMB8
proteasome (prosome, macropain) subunit, beta





type, 8 (large multifunctional protease 7)


472.
1407
CRY1
cryptochrome 1 (photolyase-like)


473.
11177
BAZ1A
bromodomain adjacent to zinc finger domain, 1A


474.
51015
ISOC1
isochorismatase domain containing 1


475.
1789
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta


476.
22948
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)


477.
158563
LOC158563
hypothetical protein LOC158563


478.
89891
WDR34
WD repeat domain 34


479.
119
ADD2
adducin 2 (beta)


480.
5358
PLS3
plastin 3 (T isoform)


481.
7086
TKT
transketolase (Wernicke-Korsakoff syndrome)


482.
51174
TUBD1
tubulin, delta 1


483.
23255
KIAA0802
KIAA0802


484.
54149
C21orf91
chromosome 21 open reading frame 91


485.
2271
FH
fumarate hydratase


486.
55076
TMEM45A
transmembrane protein 45A


487.
10436
C2F
C2f protein


488.
8553
BHLHB2
basic helix-loop-helix domain containing, class B, 2


489.
10409
BASP1
brain abundant, membrane attached signal protein 1


490.
22856
CHSY1
carbohydrate (chondroitin) synthase 1


491.
84451
KIAA1804
mixed lineage kinase 4


492.
3150
HMGN1
high-mobility group nucleosome binding domain 1


493.
961
CD47
CD47 antigen (Rh-related antigen, integrin-





associated signal transducer)


494.
79038
ZFYVE21
zinc finger, FYVE domain containing 21


495.
7291
TWIST1
twist homolog 1 (acrocephalosyndactyly 3; Saethre-





Chotzen syndrome) (Drosohila)


496.
9738
CP110
CP110 protein


497.
10625
IVNS1ABP
influenza virus NS1A binding protein


498.
9368
SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger),





isoform 3 regulator 1


499.
3613
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2


500.
8514
KCNAB2
potassium voltage-gated channel, shaker-related





subfamily, beta member 2


501.
4957
ODF2
outer dense fiber of sperm tails 2


502.
4673
NAP1L1
nucleosome assembly protein 1-like 1


503.
26018
LRIG1
leucine-rich repeats and immunoglobulin-like





domains 1


504.
3033
HADHSC
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short





chain


505.
139886
LOC139886
hypothetical protein LOC139886


506.
10360
NPM3
nucleophosmin/nucleoplasmin, 3


507.
200894
ARL2L1
ADP-ribosylation factor-like 2-like 1


508.
8364
HIST1H4C
histone 1, H4c


509.
378708
APITD1
apoptosis-inducing, TAF9-like domain 1


510.
169270
ZNF596
zinc finger protein 596


511.
6917
TCEA1
transcription elongation factor A (SII), 1


512.
7091
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog,





Drosophila)


513.
3725
JUN
v-jun sarcoma virus 17 oncogene homolog (avian)


514.
1736
DKC1
dyskeratosis congenita 1, dyskerin


515.
8566
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase


516.
51176
LEF1
lymphoid enhancer-binding factor 1


517.
87
ACTN1
actinin, alpha 1


518.
10838
ZNF275
zinc finger protein 275


519.
54517
FLJ20485
hypothetical protein FLJ20485


520.
5150
PDE7A
phosphodiesterase 7A


521.
384
ARG2
arginase, type II


522.
27316
RBMX
RNA binding motif protein, X-linked


523.
389206
CCDC4
coiled-coil domain containing 4


524.
51312
SLC25A37
solute carrier family 25, member 37


525.
9112
MTA1
metastasis associated 1


526.
6711
SPTBN1
spectrin, beta, non-erythrocytic 1


527.
10129
13CDNA73
hypothetical protein CG003


528.
80014
BOMB
BH3-only member B protein


529.
27131
SNX5
sorting nexin 5


530.
23089
PEG10
paternally expressed 10


531.
5270
SERPINE2
serine (or cysteine) proteinase inhibitor, clade E





(nexin, plasminogen activator inhibitor type 1),





member 2


532.
6764
ST5
suppression of tumorigenicity 5


533.
7791
ZYX
zyxin


534.
22995
Cep152
KIAA0912 protein


535.
4137
MAPT
microtubule-associated protein tau


536.
5411
PNN
pinin, desmosome associated protein


537.
3087
HHEX
hematopoietically expressed homeobox


538.
23171
GPD1L
glycerol-3-phosphate dehydrogenase 1-like


539.
56905
DKFZP434H132
DKFZP434H132 protein


540.
3189
HNRPH3
heterogeneous nuclear ribonucleoprotein H3 (2H9)


541.
9099
USP2
ubiquitin specific protease 2


542.
10098
TSPAN5
tetraspanin 5


543.
401505
C9orf105
chromosome 9 open reading frame 105


544.
51444
RNF138
ring finger protein 138


545.
11118
BTN3A2
butyrophilin, subfamily 3, member A2


546.
8089
YEATS4
YEATS domain containing 4


547.
84108
PCGF6
polycomb group ring finger 6


548.
7514
XPO1
exportin 1 (CRM1 homolog, yeast)


549.
9818
NUPL1
nucleoporin like 1


550.
10923
PC4
activated RNA polymerase II transcription cofactor 4


551.
6526
SLC5A3
solute carrier family 5 (inositol transporters),





member 3


552.
26010
DNAPTP6
DNA polymerase-transactivated protein 6


553.
5307
PITX1
paired-like homeodomain transcription factor 1


554.
2643
GCH1
GTP cyclohydrolase 1 (dopa-responsive dystonia)


555.
1503
CTPS
CTP synthase


556.
5777
PTPN6
protein tyrosine phosphatase, non-receptor type 6


557.
23122
CLASP2
cytoplasmic linker associated protein 2


558.
5588
PRKCQ
protein kinase C, theta


559.
64770
CCDC14
coiled-coil domain containing 14


560.
6426
SFRS1
splicing factor, arginine/serine-rich 1 (splicing factor





2, alternate splicing factor)


561.
81831
NETO2
neuropilin (NRP) and tolloid (TLL)-like 2


562.
56888
KCMF1
potassium channel modulatory factor 1


563.
9221
NOLC1
nucleolar and coiled-body phosphoprotein 1


564.
79366
NSBP1
nucleosomal binding protein 1


565.
51729
WBP11
WW domain binding protein 11


566.
84444
DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)


567.
80218
MAK3
Mak3 homolog (S. cerevisiae)


568.
84319
MGC4308
hypothetical protein MGC4308


569.
112479
MGC16943
similar to RIKEN cDNA 4933424N09 gene


570.
64396
GMCL1L
germ cell-less homolog 1 (Drosophila)-like


571.
5905
RANGAP1
Ran GTPase activating protein 1


572.
2177
FANCD2
Fanconi anemia, complementation group D2


573.
55632
KIAA1333
KIAA1333


574.
3695
ITGB7
integrin, beta 7


575.
9793
CKAP5
cytoskeleton associated protein 5


576.
5318
PKP2
plakophilin 2


577.
6652
SORD
sorbitol dehydrogenase


578.
80709
AKNA
AT-hook transcription factor


579.
55120
FANCL
Fanconi anemia, complementation group L


580.
92667
C20orf72
chromosome 20 open reading frame 72


581.
3654
IRAK1
interleukin-1 receptor-associated kinase 1


582.
55975
KLHL7
kelch-like 7 (Drosophila)


583.
6397
SEC14L1
SEC14-like 1 (S. cerevisiae)


584.
29117
BRD7
bromodomain containing 7


585.
6732
SRPK1
SFRS protein kinase 1


586.
401081
FLJ22763
hypothetical gene supported by AK026416


587.
8520
HAT1
histone acetyltransferase 1


588.
3119
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1


589.
7283
TUBG1
tubulin, gamma 1


590.
4809
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)


591.
2778
GNAS
GNAS complex locus


592.
5359
PLSCR1
phospholipid scramblase 1


593.
196294
FLJ25059
hypothetical protein FLJ25059


594.
3181
HNRPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1


595.
1794
DOCK2
dedicator of cytokinesis 2


596.
55148
C14orf130
chromosome 14 open reading frame 130


597.
25924
MYRIP
myosin VIIA and Rab interacting protein


598.
7533
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-





monooxygenase activation protein, eta polypeptide


599.
64968
MRPS6
mitochondrial ribosomal protein S6


600.
4830
NME1
non-metastatic cells 1, protein (NM23A) expressed





in


601.
165055
FLJ32745
hypothetical protein FLJ32745


602.
151827
LRRC34
leucine rich repeat containing 34


603.
93081
LOC93081
hypothetical protein BC015148


604.
196527
TMEM16F
transmembrane protein 16F


605.
1827
DSCR1
Down syndrome critical region gene 1


606.
203562
TMEM31
transmembrane protein 31


607.
11335
CBX3
chromobox homolog 3 (HP1 gamma homolog,





Drosophila)


608.
3662
IRF4
interferon regulatory factor 4


609.
8624
DSCR2
Down syndrome critical region gene 2


610.
4092
SMAD7
SMAD, mothers against DPP homolog 7





(Drosophila)


611.
6934
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-





box)


612.
26112
DKFZP434C171
DKFZP434C171 protein


613.
3329
HSPD1
heat shock 60 kDa protein 1 (chaperonin)


614.
5577
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II,





beta


615.
3202
HOXA5
homeo box A5


616.
79442
LRRC2
leucine rich repeat containing 2


617.
9631
NUP155
nucleoporin 155 kDa


618.
55366
LGR4
leucine-rich repeat-containing G protein-coupled





receptor 4


619.
23350
SR140
U2-associated SR140 protein


620.
6434
SFRS10
splicing factor, arginine/serine-rich 10 (transformer 2





homolog, Drosophila)


621.
7975
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene





homolog K (avian)


622.
3187
HNRPH1
heterogeneous nuclear ribonucleoprotein H1 (H)


623.
94239
H2AFV
H2A histone family, member V


624.
54913
RPP25
ribonuclease P 25 kDa subunit


625.
9521
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1


626.
5471
PPAT
phosphoribosyl pyrophosphate amidotransferase


627.
340252
ZNF680
zinc finger protein 680


628.
1021
CDK6
cyclin-dependent kinase 6


629.
10560
SLC19A2
solute carrier family 19 (thiamine transporter),





member 2


630.
4201
MEA1
male-enhanced antigen 1


631.
440145
LOC440145
similar to RIKEN cDNA 2410129H14


632.
3843
RANBP5
RAN binding protein 5


633.
3298
HSF2
heat shock transcription factor 2


634.
387914
TMEM46
transmembrane protein 46


635.
27347
STK39
serine threonine kinase 39 (STE20/SPS1 homolog,





yeast)


636.
6256
RXRA
retinoid X receptor, alpha


637.
6637
SNRPG
small nuclear ribonucleoprotein polypeptide G


638.
22800
RRAS2
related RAS viral (r-ras) oncogene homolog 2


639.
91694
FLJ23749
hypothetical protein FLJ23749


640.
22823
MTF2
metal response element binding transcription factor 2


641.
51184
MGC14560
protein x 0004


642.
10856
RUVBL2
RuvB-like 2 (E. coli)


643.
7188
TRAF5
TNF receptor-associated factor 5


644.
5272
SERPINB9
serine (or cysteine) proteinase inhibitor, clade B





(ovalbumin), member 9


645.
11169
WDHD1
WD repeat and HMG-box DNA binding protein 1


646.
5606
MAP2K3
mitogen-activated protein kinase kinase 3


647.
4783
NFIL3
nuclear factor, interleukin 3 regulated


648.
51691
LSM8
LSM8 homolog, U6 small nuclear RNA associated





(S. cerevisiae)


649.
1528
CYB5
cytochrome b-5


650.
79899
FLJ14213
hypothetical protein FLJ14213


651.
7334
UBE2N
ubiquitin-conjugating enzyme E2N (UBC13





homolog, yeast)


652.
2730
GCLM
glutamate-cysteine ligase, modifier subunit


653.
23157
SEPT6
septin 6


654.
56155
TEX14
testis expressed sequence 14


655.
23658
LSM5
LSM5 homolog, U6 small nuclear RNA associated





(S. cerevisiae)


656.
1400
CRMP1
collapsin response mediator protein 1


657.
5684
PSMA3
proteasome (prosome, macropain) subunit, alpha





type, 3


658.
6713
SQLE
squalene epoxidase


659.
84955
NUDCD1
NudC domain containing 1


660.
64318
C10orf117
chromosome 10 open reading frame 117


661.
10196
HRMT1L3
HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)


662.
29841
GRHL1
grainyhead-like 1 (Drosophila)


663.
10055
SAE1
SUMO-1 activating enzyme subunit 1


664.
9214
FAIM3
Fas apoptotic inhibitory molecule 3


665.
57406
ABHD6
abhydrolase domain containing 6


666.
25914
RTTN
rotatin


667.
23244
SCC-112
SCC-112 protein


668.
3183
HNRPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)


669.
55117
SLC6A15
solute carrier family 6, member 15


670.
6950
TCP1
t-complex 1


671.
4660
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit





12B


672.
134429
STARD4
START domain containing 4, sterol regulated


673.
157503
LOC157503
hypothetical protein LOC157503


674.
253832
ZDHHC20
zinc finger, DHHC-type containing 20


675.
375061
MGC15887
hypothetical gene supported by BC009447


676.
84986
ARHGAP19
Rho GTPase activating protein 19


677.
8407
TAGLN2
transgelin 2


678.
285704
RGMB
RGM domain family, member B


679.
5050
PAFAH1B3
platelet-activating factor acetylhydrolase, isoform Ib,





gamma subunit 29 kDa


680.
4208
MEF2C
MADS box transcription enhancer factor 2,





polypeptide C (myocyte enhancer factor 2C)


681.
55614
C20orf23
chromosome 20 open reading frame 23


682.
388796
LOC388796
hypothetical LOC388796


683.
85463
ZC3H12C
zinc finger CCCH-type containing 12C


684.
51465
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6





homolog, yeast)


685.
9994
CASP8AP2
CASP8 associated protein 2


686.
26135
PAI-RBP1
PAI-1 mRNA binding protein


687.
5634
PRPS2
phosphoribosyl pyrophosphate synthetase 2


688.
286319
TUSC1
tumor suppressor candidate 1


689.
6470
SHMT1
serine hydroxymethyltransferase 1 (soluble)


690.
9397
NMT2
N-myristoyltransferase 2


691.
10762
NUP50
nucleoporin 50 kDa


692.
201161
PRR6
proline rich 6


693.
5019
OXCT1
3-oxoacid CoA transferase 1


694.
159
ADSS
adenylosuccinate synthase


695.
23587
DERP6
S-phase 2 protein


696.
10151
HNRPA3P1
heterogeneous nuclear ribonucleoprotein A3





pseudogene 1


697.
8564
KMO
kynurenine 3-monooxygenase (kynurenine 3-





hydroxylase)


698.
1349
COX7B
cytochrome c oxidase subunit VIIb


699.
283824
LOC283824
hypothetical protein LOC283824


700.
1123
CHN1
chimerin (chimaerin) 1


701.
57522
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1


702.
253782
LASS6
LAG1 longevity assurance homolog 6 (S. cerevisiae)


703.
57685
KIAA1573
KIAA1573 protein


704.
79695
GALNT12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide





N-acetylgalactosaminyltransferase 12 (GalNAc-T12)


705.
90861
C16orf34
chromosome 16 open reading frame 34


706.
26207
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1


707.
1164
CKS2
CDC28 protein kinase regulatory subunit 2


708.
396
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha


709.
57530
CGN
cingulin


710.
1633
DCK
deoxycytidine kinase


711.
9208
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1


712.
6453
ITSN1
intersectin 1 (SH3 domain protein)


713.
24147
FJX1
four jointed box 1 (Drosophila)


714.
9882
TBC1D4
TBC1 domain family, member 4


715.
169200
DKFZp762C1112
hypothetical protein DKFZp762C1112


716.
9331
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4-





galactosyltransferease, polypeptide 6


717.
55183
RIF1
RAP1 interacting factor homolog (yeast)


718.
221362
LOC221362
hypothetical protein LOC221362


719.
8458
TTF2
transcription termination factor, RNA polymerase II


720.
1047
CLGN
calmegin


721.
56919
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33


722.
93949
CXorf10
chromosome X open reading frame 10


723.
5569
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor





alpha


724.
6891
TAP2
transporter 2, ATP-binding cassette, sub-family B





(MDR/TAP)


725.
1960
EGR3
early growth response 3


726.
11252
PACSIN2
protein kinase C and casein kinase substrate in





neurons 2


727.
51762
RAB8B
RAB8B, member RAS oncogene family


728.
81575
DKFZP434F0318
hypothetical protein DKFZp434F0318


729.
56906
THAP10
THAP domain containing 10


730.
55110
FLJ10292
mago-nashi homolog


731.
5267
SERPINA4
serine (or cysteine) proteinase inhibitor, clade A





(alpha-1 antiproteinase, antitrypsin), member 4


732.
1844
DUSP2
dual specificity phosphatase 2


733.
9612
NCOR2
nuclear receptor co-repressor 2


734.
3276
HRMT1L2
HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)


735.
257415
MGC40405
hypothetical protein MGC40405


736.
79720
FLJ12750
hypothetical protein FLJ12750


737.
160897
ITR
intimal thickness-related receptor


738.
4522
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+





dependent) 1, methenyltetrahydrofolate





cyclohydrolase, formyltetrahydrofolate synthetase


739.
4668
NAGA
N-acetylgalactosaminidase, alpha-


740.
84890
C10orf22
chromosome 10 open reading frame 22


741.
5198
PFAS
phosphoribosylformylglycinamidine synthase (FGAR





amidotransferase)


742.
55544
RNPC1
RNA-binding region (RNP1, RRM) containing 1


743.
2618
GART
phosphoribosylglycinamide formyltransferase,





phoshoribosylglycinamide synthetase,





phosphoribosylaminoimidazole synthetase


744.
9261
MAPKAPK2
mitogen-activated protein kinase-activated protein





kinase 2


745.
285761
DCBLD1
discoidin, CUB and LCCL domain containing 1


746.
23225
NUP210
nucleoporin 210 kDa


747.
9792
SERTAD2
SERTA domain containing 2


748.
56938
ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2


749.
23254
KIAA1026
kazrin


750.
4628
MYH10
myosin, heavy polypeptide 10, non-muscle


751.
23176
SEPT8
septin 8


752.
1432
MAPK14
mitogen-activated protein kinase 14


753.
84549
RBM13
RNA binding motif protein 13


754.
84133
ZNRF3
zinc and ring finger 3


755.
6502
SKP2
S-phase kinase-associated protein 2 (p45)


756.
59274
MESDC1
mesoderm development candidate 1


757.
51496
HSPC129
hypothetical protein HSPC129


758.
55151
TMEM38B
transmembrane protein 38B


759.
57609
KIAA1463
KIAA1463 protein


760.
1039
CDR2
cerebellar degeneration-related protein 2, 62 kDa


761.
143098
MPP7
membrane protein, palmitoylated 7 (MAGUK p55





subfamily member 7)


762.
130589
GALM
galactose mutarotase (aldose 1-epimerase)


763.
3937
LCP2
lymphocyte cytosolic protein 2 (SH2 domain





containing leukocyte protein of 76 kDa)


764.
5420
PODXL
podocalyxin-like


765.
6509
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid





transporter), member 4


766.
64397
ZFP106
zinc finger protein 106 homolog (mouse)


767.
4860
NP
nucleoside phosphorylase


768.
3535
IGL@
immunoglobulin lambda locus


769.
1396
CRIP1
cysteine-rich protein 1 (intestinal)


770.
1660
DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9


771.
4291
MLF1
myeloid leukemia factor 1


772.
26973
CHORDC1
cysteine and histidine-rich domain (CHORD)-





containing, zinc binding protein 1


773.
81037
CRR9
cisplatin resistance related protein CRR9p


774.
10574
CCT7
chaperonin containing TCP1, subunit 7 (eta)


775.
79892
C10orf119
chromosome 10 open reading frame 119


776.
9972
NUP153
nucleoporin 153 kDa


777.
10459
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)


778.
483
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide


779.
7552
ZNF6
zinc finger protein 6 (CMPX1)


780.
8165
AKAP1
A kinase (PRKA) anchor protein 1


781.
29097
CNIH4
cornichon homolog 4 (Drosophila)


782.
11198
SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)


783.
2184
FAH
fumarylacetoacetate hydrolase





(fumarylacetoacetase)


784.
7037
TFRC
transferrin receptor (p90, CD71)


785.
6461
SHB
Src homology 2 domain containing adaptor protein B


786.
509
ATP5C1
ATP synthase, H+ transporting, mitochondrial F1





complex, gamma polypeptide 1


787.
5591
PRKDC
protein kinase, DNA-activated, catalytic polypeptide


788.
10682
EBP
emopamil binding protein (sterol isomerase)


789.
9188
DDX21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21


790.
3837
KPNB1
karyopherin (importin) beta 1


791.
3191
HNRPL
heterogeneous nuclear ribonucleoprotein L


792.
10236
HNRPR
heterogeneous nuclear ribonucleoprotein R


793.
6907
TBL1X
transducin (beta)-like 1X-linked


794.
56172
ANKH
ankylosis, progressive homolog (mouse)


795.
23367
LARP1
La ribonucleoprotein domain family, member 1


796.
5778
PTPN7
protein tyrosine phosphatase, non-receptor type 7


797.
100
ADA
adenosine deaminase


798.
2821
GPI
glucose phosphate isomerase


799.
9697
TRAM2
translocation associated membrane protein 2


800.
54927
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3


801.
58478
MASA
E-1 enzyme


802.
6322
SCML1
sex comb on midleg-like 1 (Drosophila)


803.
292
SLC25A5
solute carrier family 25 (mitochondrial carrier;





adenine nucleotide translocator), member 5


804.
10857
PGRMC1
progesterone receptor membrane component 1


805.
55342
STRBP
spermatid perinuclear RNA binding protein


806.
7150
TOP1
topoisomerase (DNA) I


807.
874
GBR3
carbonyl reductase 3


808.
51096
WDR50
WD repeat domain 50


809.
253558
LYCAT
lysocardiolipin acyltransferase


810.
79053
ALG8
asparagine-linked glycosylation 8 homolog (yeast,





alpha-1,3-glucosyltransferase)


811.
84300
C6orf125
chromosome 6 open reading frame 125


812.
8975
USP13
ubiquitin specific protease 13 (isopeptidase T-3)


813.
220988
HNRPA3
heterogeneous nuclear ribonucleoprotein A3


814.
5315
PKM2
pyruvate kinase, muscle


815.
7411
VBP1
von Hippel-Lindau binding protein 1


816.
1665
DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15


817.
10963
STIP1
stress-induced-phosphoprotein 1 (Hsp70/Hsp90-





organizing protein)


818.
253461
ZBTB38
zinc finger and BTB domain containing 38


819.
29080
HSPC128
HSPC128 protein


820.
84275
MGC4399
mitochondrial carrier protein


821.
1622
DBI
diazepam binding inhibitor (GABA receptor





modulator, acyl-Coenzyme A binding protein)


822.
4953
ODC1
ornithine decarboxylase 1


823.
2029
ENSA
endosulfine alpha


824.
6404
SELPLG
selectin P ligand


825.
81034
MFTC
mitochondrial folate transporter/carrier


826.
81542
TXNDC
thioredoxin domain containing


827.
25816
TNFAIP8
tumor necrosis factor, alpha-induced protein 8


828.
51582
AZIN1
antizyme inhibitor 1


829.
27436
EML4
echinoderm microtubule associated protein like 4


830.
55720
FLJ10534
hypothetical protein FLJ10534


831.
7295
TXN
thioredoxin


832.
10539
TXNL2
thioredoxin-like 2


833.
86
ACTL6A
actin-like 6A


834.
6731
SRP72
signal recognition particle 72 kDa


835.
23314
SATB2
SATB family member 2


836.
2273
FHL1
four and a half LIM domains 1


837.
3422
IDI1
isopentenyl-diphosphate delta isomerase


838.
10935
PRDX3
peroxiredoxin 3


839.
2958
GTF2A2
general transcription factor IIA, 2, 12 kDa


840.
4144
MAT2A
methionine adenosyltransferase II, alpha


841.
1964
EIF1AX
eukaryotic translation initiation factor 1A, X-linked


842.
60
ACTB
actin, beta


843.
11191
PTENP1
phosphatase and tensin homolog (mutated in





multiple advanced cancers 1), pseudogene 1


844.
90843
TCEAL8
transcription elongation factor A (SII)-like 8


845.
57181
SLC39A10
solute carrier family 39 (zinc transporter), member





10


846.
11147
HHLA3
HERV-H LTR-associating 3


847.
10553
HTATIP2
HIV-1 Tat interactive protein 2, 30 kDa


848.
3338
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4


849.
84888
SPPL2A
signal peptide peptidase-like 2A


850.
1955
EGFL5
EGF-like-domain, multiple 5


851.
329
BIRC2
baculoviral IAP repeat-containing 2


852.
29927
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)


853.
9559
VPS26
vacuolar protein sorting 26 (yeast)


854.
23270
TSPYL4
TSPY-like 4


855.
6309
SC5DL
sterol-C5-desaturase (ERG3 delta-5-desaturase





homolog, fungal)-like


856.
10397
NDRG1
N-myc downstream regulated gene 1


857.
27032
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1


858.
11112
HIBADH
3-hydroxyisobutyrate dehydrogenase


859.
1476
CSTB
cystatin B (stefin B)


860.
9620
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1





(flamingo homolog, Drosophila)


861.
56650
C3orf4
chromosome 3 open reading frame 4


862.
29922
NME7
non-metastatic cells 7, protein expressed in





(nucleoside-diphosphate kinase)


863.
8887
TAX1BP1
Tax1 (human T-cell leukemia virus type I) binding





protein 1


864.
5445
PON2
paraoxonase 2


865.
81889
FAHD1
fumarylacetoacetate hydrolase domain containing 1


866.
694
BTG1
B-cell translocation gene 1, anti-proliferative


867.
29058
C20orf30
chromosome 20 open reading frame 30


868.
2752
GLUL
glutamate-ammonia ligase (glutamine synthase)


869.
79717
FLJ11838
hypothetical protein FLJ11838


870.
170622
COMMD6
COMM domain containing 6


871.
5792
PTPRF
protein tyrosine phosphatase, receptor type, F


872.
64393
WIG1
p53 target zinc finger protein


873.
549
AUH
AU RNA binding protein/enoyl-Coenzyme A





hydratase


874.
51282
SCAND1
SCAN domain containing 1


875.
79027
ZNF655
zinc finger protein 655


876.
6451
SH3BGRL
SH3 domain binding glutamic acid-rich protein like


877.
1347
COX7A2
cytochrome c oxidase subunit VIIa polypeptide 2





(liver)


878.
550643
LOC550643
hypothetical protein LOC550643


879.
6926
TBX3
T-box 3 (ulnar mammary syndrome)


880.
51614
SDBCAG84
serologically defined breast cancer antigen 84


881.
9520
NPEPPS
aminopeptidase puromycin sensitive


882.
51065
RPS27L
ribosomal protein S27-like


883.
10116
FEM1B
fem-1 homolog b (C. elegans)


884.
10521
DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17


885.
81557
MAGED4
melanoma antigen family D, 4


886.
10133
OPTN
optineurin


887.
54504
CPVL
carboxypeptidase, vitellogenic-like


888.
64082
C13orf10
chromosome 13 open reading frame 10


889.
401115
LOC401115
hypothetical gene supported by BC038466;





BC062790


890.
6892
TAPBP
TAP binding protein (tapasin)


891.
8087
FXR1
fragile X mental retardation, autosomal homolog 1


892.
7905
C5orf18
chromosome 5 open reading frame 18


893.
3916
LAMP1
lysosomal-associated membrane protein 1


894.
22982
KIAA0934
KIAA0934


895.
55615
PRR5
proline rich protein 5


896.
5651
PRSS7
protease, serine, 7 (enterokinase)


897.
10449
ACAA2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial





3-oxoacyl-Coenzyme A thiolase)


898.
8934
RAB7L1
RAB7, member RAS oncogene family-like 1


899.
10114
HIPK3
homeodomain interacting protein kinase 3


900.
57560
WDR56
WD repeat domain 56


901.
51205
ACP6
acid phosphatase 6, lysophosphatidic


902.
6238
RRBP1
ribosome binding protein 1 homolog 180 kDa (dog)


903.
151011
SEPT10
septin 10


904.
22920
KIFAP3
kinesin-associated protein 3


905.
3958
LGALS3
lectin, galactoside-binding, soluble, 3 (galectin 3)


906.
84186
ZCCHC7
zinc finger, CCHC domain containing 7


907.
9452
ITM2A
integral membrane protein 2A


908.
10159
ATP6AP2
ATPase, H+ transporting, lysosomal accessory





protein 2


909.
23641
LDOC1
leucine zipper, down-regulated in cancer 1


910.
967
CD63
CD63 antigen (melanoma 1 antigen)


911.
2517
FUCA1
fucosidase, alpha-L-1, tissue


912.
23219
FBXO28
F-box protein 28


913.
79982
DNAJB14
DnaJ (Hsp40) homolog, subfamily B, member 14


914.
7328
UBE2H
ubiquitin-conjugating enzyme E2H (UBC8 homolog,





yeast)


915.
23355
KIAA0804
KIAA0804


916.
257103
C21orf86
chromosome 21 open reading frame 86


917.
6307
SC4MOL
sterol-C4-methyl oxidase-like


918.
23376
KIAA0776
KIAA0776


919.
57700
KIAA1600
KIAA1600


920.
85461
TANC
TPR domain, ankyrin-repeat and coiled-coil-





containing


921.
4247
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-





acetylglucosaminyltransferase


922.
3383
ICAM1
intercellular adhesion molecule 1 (CD54), human





rhinovirus receptor


923.
493812
HCG11
HLA complex group 11


924.
5921
RASA1
RAS p21 protein activator (GTPase activating





protein) 1


925.
23563
CHST5
carbohydrate (N-acetylglucosamine 6-O)





sulfotransferase 5


926.
51100
SH3GLB1
SH3-domain GRB2-like endophilin B1


927.
339988
LOC339988
hypothetical protein LOC339988


928.
79080
MGC2574
hypothetical protein MGC2574


929.
55761
TTC17
tetratricopeptide repeat domain 17


930.
144871
LOC144871
hypothetical protein LOC144871


931.
4194
MDM4
Mdm4, transformed 3T3 cell double minute 4, p53





binding protein (mouse)


932.
51030
FAM18B
family with sequence similarity 18, member B


933.
1650
DDOST
dolichyl-diphosphooligosaccharide-protein





glycosyltransferase


934.
147463
ANKRD29
ankyrin repeat domain 29


935.
3757
KCNH2
potassium voltage-gated channel, subfamily H (eag-





related), member 2


936.
116442
RAB39B
RAB39B, member RAS oncogene family


937.
10972
TMP21
transmembrane trafficking protein


938.
57798
GATAD1
GATA zinc finger domain containing 1


939.
1314
COPA
coatomer protein complex, subunit alpha


940.
2581
GALC
galactosylceramidase (Krabbe disease)


941.
91452
ACBD5
acyl-Coenzyme A binding domain containing 5


942.
8879
SGPL1
sphingosine-1-phosphate lyase 1


943.
4897
NRCAM
neuronal cell adhesion molecule


944.
23209
MLC1
megalencephalic leukoencephalopathy with





subcortical cysts 1


945.
440270
LOC440270
golgin-67


946.
5034
P4HB
procollagen-proline, 2-oxoglutarate 4-dioxygenase





(proline 4-hydroxylase), beta polypeptide (protein





disulfide isomerase-associated 1)


947.
148646
FLJ32096
hypothetical protein FLJ32096


948.
399917
LOC399917
similar to polymerase


949.
7096
TLR1
toll-like receptor 1


950.
80853
KIAA1718
KIAA1718 protein


951.
378938
MALAT1
metastasis associated lung adenocarcinoma





transcript 1 (non-coding RNA)


952.
1266
CNN3
calponin 3, acidic


953.
58486
LOC58486
transposon-derived Buster1 transposase-like protein





gene


954.
1040
CDS1
CDP-diacylglycerol synthase (phosphatidate





cytidylyltransferase) 1


955.
9895
KIAA0329
KIAA0329


956.
1509
CTSD
cathepsin D (lysosomal aspartyl protease)


957.
26115
DKFZP564D166
putative ankyrin-repeat containing protein


958.
57162
PELI1
pellino homolog 1 (Drosophila)


959.
57599
WDR48
WD repeat domain 48


960.
285464
FLJ34443
hypothetical protein FLJ34443


961.
55857
C20orf19
chromosome 20 open reading frame 19


962.
339456
LOC339456
hypothetical protein LOC339456


963.
51569
UFM1
ubiquitin-fold modifier 1


964.
582
BBS1
Bardet-Biedl syndrome 1


965.
4637
MYL6
myosin, light polypeptide 6, alkali, smooth muscle





and non-muscle


966.
1186
CLCN7
chloride channel 7


967.
3490
IGFBP7
insulin-like growth factor binding protein 7


968.
5095
PCCA
propionyl Coenzyme A carboxylase, alpha





polypeptide


969.
10966
RAB40B
RAB40B, member RAS oncogene family


970.
285362
SUMF1
sulfatase modifying factor 1


971.
56122
PCDHB14
protocadherin beta 14


972.
57534
MIB1
mindbomb homolog 1 (Drosophila)


973.
56951
C5orf15
chromosome 5 open reading frame 15


974.
113177
C19orf36
chromosome 19 open reading frame 36


975.
10379
ISGF3G
interferon-stimulated transcription factor 3, gamma





48 kDa


976.
64224
FLJ22313
hypothetical protein FLJ22313


977.
65084
FLJ22104
hypothetical protein FLJ22104


978.
10537
UBD
ubiquitin D


979.
8548
BLZF1
basic leucine zipper nuclear factor 1 (JEM-1)


980.
284214
LOC284214
hypothetical protein LOC284214


981.
8334
HIST1H2AC
histone 1, H2ac


982.
80210
FLJ12584
melanoma/melanocyte specific protein KU-MEL-1


983.
1182
CLCN3
chloride channel 3


984.
26751
SH3YL1
SH3 domain containing, Ysc84-like 1 (S. cerevisiae)


985.
114327
EFHC1
EF-hand domain (C-terminal) containing 1


986.
7351
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)


987.
10724
MGEA5
meningioma expressed antigen 5 (hyaluronidase)


988.
9652
KIAA0372
KIAA0372


989.
200958
MUC20
mucin 20


990.
161527
LOC161527
hypothetical protein LOC161527


991.
10314
LANCL1
LanC lantibiotic synthetase component C-like 1





(bacterial)


992.
2923
PDIA3
protein disulfide isomerase family A, member 3


993.
84247
LDOC1L
leucine zipper, down-regulated in cancer 1-like


994.
3006
HIST1H1C
histone1, H1c


995.
9562
MINPP1
multiple inositol polyphosphate histidine





phosphatase, 1


996.
115024
MGC20781
hypothetical protein MGC20781


997.
65982
FLJ12895
hypothetical protein FLJ12895


998.
5268
SERPINB5
serine (or cysteine) proteinase inhibitor, clade B





(ovalbumin), member 5


999.
94240
EPSTI1
epithelial stromal interaction 1 (breast)


1000.
2621
GAS6
growth arrest-specific 6


1001.
401024
FLJ44048
FLJ44048 protein


1002.
57142
RTN4
reticulon 4


1003.
50854
C6orf48
chromosome 6 open reading frame 48


1004.
317649
EIF4E3
eukaryotic translation initiation factor 4E member 3


1005.
4179
MCP
membrane cofactor protein (CD46, trophoblast-





lymphocyte cross-reactive antigen)


1006.
54884
RetSat
all-trans-13,14-dihydroretinol saturase


1007.
10154
PLXNC1
plexin C1


1008.
2630
GBAP
glucosidase, beta; acid, pseudogene


1009.
7077
TIMP2
tissue inhibitor of metalloproteinase 2


1010.
23741
CRI1
CREBBP/EP300 inhibitor 1


1011.
949
SCARB1
scavenger receptor class B, member 1


1012.
1519
CTSO
cathepsin O


1013.
51136
LOC51136
PTD016 protein


1014.
3428
IFI16
interferon, gamma-inducible protein 16


1015.
9516
LITAF
lipopolysaccharide-induced TNF factor


1016.
3123
HLA-DRB1
major histocompatibility complex, class II, DR beta 1


1017.
1389
CREBL2
cAMP responsive element binding protein-like 2


1018.
5027
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7


1019.
6782
STCH
stress 70 protein chaperone, microsome-associated,





60 kDa


1020.
5645
PRSS2
protease, serine, 2 (trypsin 2)


1021.
84282
RNF135
ring finger protein 135


1022.
9852
EPM2AIP1
EPM2A (laforin) interacting protein 1


1023.
84333
PCGF5
polycomb group ring finger 5


1024.
23475
QPRT
quinolinate phosphoribosyltransferase (nicotinate-





nucleotide pyrophosphorylase (carboxylating))


1025.
11142
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor





gamma


1026.
54832
VPS13C
vacuolar protein sorting 13C (yeast)


1027.
1486
CTBS
chitobiase, di-N-acetyl-


1028.
4601
MXI1
MAX interactor 1


1029.
1365
CLDN3
claudin 3


1030.
81622
UNC93B1
unc-93 homolog B1 (C. elegans)


1031.
54664
FLJ11273
hypothetical protein FLJ11273


1032.
9993
DGCR2
DiGeorge syndrome critical region gene 2


1033.
57179
KIAA1191
KIAA1191 protein


1034.
55958
KLHL9
kelch-like 9 (Drosophila)


1035.
81671
TMEM49
transmembrane protein 49


1036.
9666
DZIP3
zinc finger DAZ interacting protein 3


1037.
10509
SEMA4B
sema domain, immunoglobulin domain (Ig),





transmembrane domain (TM) and short cytoplasmic





domain, semaphorin 4B


1038.
3782
KCNN3
potassium intermediate/small conductance calcium-





activated channel, subfamily N, member 3


1039.
4644
MYO5A
myosin VA (heavy polypeptide 12, myoxin)


1040.
55179
FAIM
Fas apoptotic inhibitory molecule


1041.
9687
GREB1
GREB1 protein


1042.
25861
DFNB31
deafness, autosomal recessive 31


1043.
9197
SLC33A1
solute carrier family 33 (acetyl-CoA transporter),





member 1


1044.
10549
PRDX4
peroxiredoxin 4


1045.
27090
ST6GALNAC4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-





1,3)-N-acetylgalactosaminide alpha-2,6-





sialyltransferase 4


1046.
3988
LIPA
lipase A, lysosomal acid, cholesterol esterase





(Wolman disease)


1047.
10577
NPC2
Niemann-Pick disease, type C2


1048.
441951
HSUP1
similar to RPE-spondin


1049.
26275
HIBCH
3-hydroxyisobutyryl-Coenzyme A hydrolase


1050.
401397
LOC401397
hypothetical LOC401397


1051.
81555
YIPF5
Yip1 domain family, member 5


1052.
19
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1


1053.
2896
GRN
granulin


1054.
1312
COMT
catechol-O-methyltransferase


1055.
127018
LYPLAL1
lysophospholipase-like 1


1056.
5911
RAP2A
RAP2A, member of RAS oncogene family


1057.
3017
HIST1H2BD
histone 1, H2bd


1058.
9139
CBFA2T2
core-binding factor, runt domain, alpha subunit 2;





translocated to, 2


1059.
50848
F11R
F11 receptor


1060.
3728
JUP
junction plakoglobin


1061.
8615
VDP
vesicle docking protein p115


1062.
79090
MGC2650
hypothetical protein MGC2650


1063.
51303
FKBP11
FK506 binding protein 11, 19 kDa


1064.
64747
MFSD1
major facilitator superfamily domain containing 1


1065.
23471
TRAM1
translocation associated membrane protein 1


1066.
1832
DSP
desmoplakin


1067.
125144
MGC40157
hypothetical protein MGC40157


1068.
10150
MBNL2
muscleblind-like 2 (Drosophila)


1069.
3082
HGF
hepatocyte growth factor (hepapoietin A; scatter





factor)


1070.
7750
ZNF198
zinc finger protein 198


1071.
2908
NR3C1
nuclear receptor subfamily 3, group C, member 1





(glucocorticoid receptor)


1072.
25758
G2
G2 protein


1073.
10653
SPINT2
serine protease inhibitor, Kunitz type, 2


1074.
116151
C20orf108
chromosome 20 open reading frame 108


1075.
8933
CXX1
CAAX box 1


1076.
475
ATOX1
ATX1 antioxidant protein 1 homolog (yeast)


1077.
23406
COTL1
coactosin-like 1 (Dictyostelium)


1078.
57561
ARRDC3
arrestin domain containing 3


1079.
55205
ZNF532
zinc finger protein 532


1080.
25796
PGLS
6-phosphogluconolactonase


1081.
283846
DKFZp547E087
PI-3-kinase-related kinase SMG-1-like


1082.
57185
DJ462O23.2
hypothetical protein dJ462O23.2


1083.
54431
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10


1084.
5800
PTPRO
protein tyrosine phosphatase, receptor type, O


1085.
1465
CSRP1
cysteine and glycine-rich protein 1


1086.
950
SCARB2
scavenger receptor class B, member 2


1087.
51019
CGI-116
CGI-116 protein


1088.
5476
PPGB
protective protein for beta-galactosidase





(galactosialidosis)


1089.
54145
H2BFS
H2B histone family, member S


1090.
65981
C1QDC1
C1q domain containing 1


1091.
81502
HM13
histocompatibility (minor) 13


1092.
3572
IL6ST
interleukin 6 signal transducer (gp130, oncostatin M





receptor)


1093.
1299
COL9A3
collagen, type IX, alpha 3


1094.
1386
ATF2
activating transcription factor 2


1095.
4134
MAP4
microtubule-associated protein 4


1096.
3981
LIG4
ligase IV, DNA, ATP-dependent


1097.
57714
KIAA1618
KIAA1618


1098.
80315
CPEB4
cytoplasmic polyadenylation element binding protein 4


1099.
107
ADCY1
adenylate cyclase 1 (brain)


1100.
8804
CREG1
cellular repressor of E1A-stimulated genes 1


1101.
84181
CHD6
chromodomain helicase DNA binding protein 6


1102.
22871
NLGN1
neuroligin 1


1103.
659
BMPR2
bone morphogenetic protein receptor, type II





(serine/threonine kinase)


1104.
79158
MGC4170
MGC4170 protein


1105.
112399
EGLN3
egl nine homolog 3 (C. elegans)


1106.
10550
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5


1107.
55573
H41
hypothetical protein H41


1108.
51706
NQO3A2
NAD(P)H:quinone oxidoreductase type 3,





polypeptide A2


1109.
79738
FLJ23560
hypothetical protein FLJ23560


1110.
6672
SP100
nuclear antigen Sp100


1111.
145173
B3GTL
beta 3-glycosyltransferase-like


1112.
3275
HRMT1L1
HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)


1113.
54059
C21orf57
chromosome 21 open reading frame 57


1114.
571
BACH1
BTB and CNC homology 1, basic leucine zipper





transcription factor 1


1115.
6990
TCTE1L
t-complex-associated-testis-expressed 1-like


1116.
9341
VAMP3
vesicle-associated membrane protein 3 (cellubrevin)


1117.
2180
ACSL1
acyl-CoA synthetase long-chain family member 1


1118.
2799
GNS
glucosamine (N-acetyl)-6-sulfatase (Sanfilippo





disease IIID)


1119.
9236
CCPG1
cell cycle progression 1


1120.
51111
SUV420H1
suppressor of variegation 4-20 homolog 1





(Drosophila)


1121.
598
BCL2L1
BCL2-like 1


1122.
57674
C17orf27
chromosome 17 open reading frame 27


1123.
1488
CTBP2
C-terminal binding protein 2


1124.
80267
C1orf22
chromosome 1 open reading frame 22


1125.
90701
SEC11L3
SEC11-like 3 (S. cerevisiae)


1126.
84218
TBC1D3
TBC1 domain family, member 3


1127.
7844
RNF103
ring finger protein 103


1128.
8440
NCK2
NCK adaptor protein 2


1129.
25934
NIPSNAP3A
nipsnap homolog 3A (C. elegans)


1130.
3897
L1CAM
L1 cell adhesion molecule


1131.
114915
TIGA1
TIGA1


1132.
754
PTTG1IP
pituitary tumor-transforming 1 interacting protein


1133.
10525
HYOU1
hypoxia up-regulated 1


1134.
966
CD59
CD59 antigen p18-20 (antigen identified by





monoclonal antibodies 16.3A5, EJ16, EJ30, EL32





and G344)


1135.
25976
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase


1136.
3714
JAG2
jagged 2


1137.
8780
RIOK3
RIO kinase 3 (yeast)


1138.
55827
IQWD1
IQ motif and WD repeats 1


1139.
55830
GLT8D1
glycosyltransferase 8 domain containing 1


1140.
4779
NFE2L1
nuclear factor (erythroid-derived 2)-like 1


1141.
7286
TUFT1
tuftelin 1


1142.
1028
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)


1143.
60492
MDS025
hypothetical protein MDS025


1144.
27319
BHLHB5
basic helix-loop-helix domain containing, class B, 5


1145.
1958
EGR1
early growth response 1


1146.
89796
NAV1
neuron navigator 1


1147.
9240
PNMA1
paraneoplastic antigen MA1


1148.
6773
STAT2
signal transducer and activator of transcription 2,





113 kDa


1149.
7494
XBP1
X-box binding protein 1


1150.
11057
ABHD2
abhydrolase domain containing 2


1151.
9451
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3


1152.
8878
SQSTM1
sequestosome 1


1153.
302
ANXA2
annexin A2


1154.
2590
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide





N-acetylgalactosaminyltransferase 2 (GalNAc-T2)


1155.
1200
TPP1
tripeptidyl peptidase I


1156.
5973
RENBP
renin binding protein


1157.
7259
TSPYL1
TSPY-like 1


1158.
112770
C1orf85
chromosome 1 open reading frame 85


1159.
93953
ACRC
acidic repeat containing


1160.
90634
CG018
hypothetical gene CG018


1161.
1030
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits





CDK4)


1162.
158158
RASEF
RAS and EF hand domain containing


1163.
2824
GPM6B
glycoprotein M6B


1164.
9706
ULK2
unc-51-like kinase 2 (C. elegans)


1165.
92370
ACPL2
acid phosphatase-like 2


1166.
1203
CLN5
ceroid-lipofuscinosis, neuronal 5


1167.
8337
HIST2H2AA
histone 2, H2aa


1168.
3998
LMAN1
lectin, mannose-binding, 1


1169.
56675
NRIP3
nuclear receptor interacting protein 3


1170.
4864
NPC1
Niemann-Pick disease, type C1


1171.
3358
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C


1172.
304
ANXA2P2
annexin A2 pseudogene 2


1173.
81790
RNF170
ring finger protein 170


1174.
2537
G1P3
interferon, alpha-inducible protein (clone IFI-6-16)


1175.
55251
C20orf36
chromosome 20 open reading frame 36


1176.
27344
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor


1177.
10057
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP),





member 5


1178.
81031
SLC2A10
solute carrier family 2 (facilitated glucose





transporter), member 10


1179.
467
ATF3
activating transcription factor 3


1180.
94103
ORMDL3
ORM1-like 3 (S. cerevisiae)


1181.
375593
TRIM50B
tripartite motif-containing 50B


1182.
23015
GM88
88-kDa golgi protein


1183.
55818
JMJD1A
jumonji domain containing 1A


1184.
5274
SERPINI1
serine (or cysteine) proteinase inhibitor, clade I





(neuroserpin), member 1


1185.
23336
DMN
desmuslin


1186.
255631
COL24A1
collagen, type XXIV, alpha 1


1187.
3995
FADS3
fatty acid desaturase 3


1188.
5797
PTPRM
protein tyrosine phosphatase, receptor type, M


1189.
55876
GSDML
gasdermin-like


1190.
999
CDH1
cadherin 1, type 1, E-cadherin (epithelial)


1191.
84897
TBRG1
transforming growth factor beta regulator 1


1192.
51363
GALNAC4S-6ST
B cell RAG associated protein


1193.
9961
MVP
major vault protein


1194.
2982
GUCY1A3
guanylate cyclase 1, soluble, alpha 3


1195.
706
BZRP
benzodiazapine receptor (peripheral)


1196.
144203
OVOS2
ovostatin 2


1197.
8516
ITGA8
integrin, alpha 8


1198.
2037
EPB41L2
erythrocyte membrane protein band 4.1-like 2


1199.
1524
CX3CR1
chemokine (C—X3—C motif) receptor 1


1200.
222166
EIIs1
hypothetical protein EIIs1


1201.
339803
LOC339803
hypothetical protein LOC339803


1202.
5360
PLTP
phospholipid transfer protein


1203.
1612
DAPK1
death-associated protein kinase 1


1204.
90161
HS6ST2
heparan sulfate 6-O-sulfotransferase 2


1205.
115701
ALPK2
alpha-kinase 2


1206.
50640
IPLA2(GAMMA)
intracellular membrane-associated calcium-





independent phospholipase A2 gamma


1207.
8473
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase





(UDP-N-acetylglucosamine:polypeptide-N-





acetylglucosaminyl transferase)


1208.
252839
TMEM9
transmembrane protein 9


1209.
150759
LOC150759
hypothetical protein LOC150759


1210.
401152
LOC401152
HCV F-transactivated protein 1


1211.
64065
PERP
PERP, TP53 apoptosis effector


1212.
114793
FMNL2
formin-like 2


1213.
477
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 (+)





polypeptide


1214.
59338
PLEKHA1
pleckstrin homology domain containing, family A





(phosphoinositide binding specific) member 1


1215.
3727
JUND
jun D proto-oncogene


1216.
85236
HIST1H2BK
histone 1, H2bk


1217.
6513
SLC2A1
solute carrier family 2 (facilitated glucose





transporter), member 1


1218.
155038
GIMAP8
GTPase, IMAP family member 8


1219.
3055
HCK
hemopoietic cell kinase


1220.
6542
SLC7A2
solute carrier family 7 (cationic amino acid





transporter, y+ system), member 2


1221.
8996
NOL3
nucleolar protein 3 (apoptosis repressor with CARD





domain)


1222.
9728
KIAA0256
KIAA0256 gene product


1223.
51237
PACAP
proapoptotic caspase adaptor protein


1224.
8987
GENX-3414
genethonin 1


1225.
132720
FLJ39370
hypothetical protein FLJ39370


1226.
1601
DAB2
disabled homolog 2, mitogen-responsive





phosphoprotein (Drosophila)


1227.
54741
LEPROT
leptin receptor overlapping transcript


1228.
81631
MAP1LC3B
microtubule-associated protein 1 light chain 3 beta


1229.
9473
C1orf38
chromosome 1 open reading frame 38


1230.
94241
TP53INP1
tumor protein p53 inducible nuclear protein 1


1231.
5816
PVALB
parvalbumin


1232.
115294
LOC115294
similar to hypothetical protein FLJ10883


1233.
23461
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5


1234.
10370
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-





rich carboxy-terminal domain, 2


1235.
9604
RNF14
ring finger protein 14


1236.
387263
C6orf120
chromosome 6 open reading frame 120


1237.
9120
SLC16A6
solute carrier family 16 (monocarboxylic acid





transporters), member 6


1238.
3915
LAMC1
laminin, gamma 1 (formerly LAMB2)


1239.
23092
ARHGAP26
Rho GTPase activating protein 26


1240.
64778
FNDC3B
fibronectin type III domain containing 3B


1241.
10140
TOB1
transducer of ERBB2, 1


1242.
23208
SYT11
synaptotagmin XI


1243.
57730
KIAA1641
KIAA1641


1244.
120196
MGC34830
hypothetical protein MGC34830


1245.
7832
BTG2
BTG family, member 2


1246.
23259
DDHD2
DDHD domain containing 2


1247.
84981
MGC14376
hypothetical protein MGC14376


1248.
6448
SGSH
N-sulfoglucosamine sulfohydrolase (sulfamidase)


1249.
9910
RABGAP1L
RAB GTPase activating protein 1-like


1250.
1611
DAP
death-associated protein


1251.
126823
KARCA1
kelch/ankyrin repeat containing cyclin A1 interacting





protein


1252.
388403
YPEL2
yippee-like 2 (Drosophila)


1253.
6720
SREBF1
sterol regulatory element binding transcription factor 1


1254.
58476
TP53INP2
tumor protein p53 inducible nuclear protein 2


1255.
8605
PLA2G4C
phospholipase A2, group IVC (cytosolic, calcium-





independent)


1256.
3983
ABLIM1
actin binding LIM protein 1


1257.
4189
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9


1258.
1604
DAF
decay accelerating factor for complement (CD55,





Cromer blood group system)


1259.
29994
BAZ2B
bromodomain adjacent to zinc finger domain, 2B


1260.
10156
RASA4
RAS p21 protein activator 4


1261.
9123
SLC16A3
solute carrier family 16 (monocarboxylic acid





transporters), member 3


1262.
7846
TUBA3
tubulin, alpha 3


1263.
3956
LGALS1
lectin, galactoside-binding, soluble, 1 (galectin 1)


1264.
1647
GADD45A
growth arrest and DNA-damage-inducible, alpha


1265.
6609
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal





(acid sphingomyelinase)


1266.
56904
SH3GLB2
SH3-domain GRB2-like endophilin B2


1267.
440081
DDX12
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12





(CHL1-like helicase homolog, S. cerevisiae)


1268.
5163
PDK1
pyruvate dehydrogenase kinase, isoenzyme 1


1269.
25840
DKFZP586A0522
DKFZP586A0522 protein


1270.
51566
ARMCX3
armadillo repeat containing, X-linked 3


1271.
9388
LIPG
lipase, endothelial


1272.
27250
PDCD4
programmed cell death 4 (neoplastic transformation





inhibitor)


1273.
6302
SAS
sarcoma amplified sequence


1274.
83937
RASSF4
Ras association (RalGDS/AF-6) domain family 4


1275.
388677
NOTCH2NL
Notch homolog 2 (Drosophila) N-terminal like


1276.
23646
PLD3
phospholipase D family, member 3


1277.
23643
LY96
lymphocyte antigen 96


1278.
9855
FARP2
FERM, RhoGEF and pleckstrin domain protein 2


1279.
65018
PINK1
PTEN induced putative kinase 1


1280.
57035
C1orf63
chromosome 1 open reading frame 63


1281.
85352
KIAA1644
KIAA1644 protein


1282.
283131
TncRNA
trophoblast-derived noncoding RNA


1283.
143888
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2


1284.
56204
FLJ10980
hypothetical protein FLJ10980


1285.
23446
CDW92
CDW92 antigen


1286.
23766
GABARAPL3
GABA(A) receptors associated protein like 3


1287.
1508
CTSB
cathepsin B


1288.
4094
MAF
v-maf musculoaponeurotic fibrosarcoma oncogene





homolog (avian)


1289.
22932
POMZP3
POM (POM121 homolog, rat) and ZP3 fusion


1290.
56243
KIAA1217
KIAA1217


1291.
1663
DDX11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11





(CHL1-like helicase homolog, S. cerevisiae)


1292.
1414
CRYBB1
crystallin, beta B1


1293.
154091
SLC2A12
solute carrier family 2 (facilitated glucose





transporter), member 12


1294.
4121
MAN1A1
mannosidase, alpha, class 1A, member 1


1295.
11178
LZTS1
leucine zipper, putative tumor suppressor 1


1296.
10628
TXNIP
thioredoxin interacting protein


1297.
83719
YPEL3
yippee-like 3 (Drosophila)


1298.
9863
MAGI2
membrane associated guanylate kinase, WW and





PDZ domain containing 2


1299.
5660
PSAP
prosaposin (variant Gaucher disease and variant





metachromatic leukodystrophy)


1300.
145788
FLJ27352
hypothetical LOC145788


1301.
84513
HTPAP
HTPAP protein


1302.
57612
KIAA1466
KIAA1466 gene


1303.
57515
TDE2
tumor differentially expressed 2


1304.
29005
PRO1073
PRO1073 protein


1305.
51646
YPEL5
yippee-like 5 (Drosophila)


1306.
5269
SERPINB6
serine (or cysteine) proteinase inhibitor, clade B





(ovalbumin), member 6


1307.
30061
SLC40A1
solute carrier family 40 (iron-regulated transporter),





member 1


1308.
81030
ZBP1
Z-DNA binding protein 1


1309.
347733
RP11-506K6.1
tubulin, beta polypeptide paralog


1310.
390
RND3
Rho family GTPase 3


1311.
10765
JARID1B
Jumonji, AT rich interactive domain 1B (RBP2-like)


1312.
9783
RIMS3
regulating synaptic membrane exocytosis 3


1313.
27122
DKK3
dickkopf homolog 3 (Xenopus laevis)


1314.
151556
GPR155
G protein-coupled receptor 155


1315.
8365
HIST1H4H
histone 1, H4h


1316.
6480
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1


1317.
6591
SNAI2
snail homolog 2 (Drosophila)


1318.
54800
DRE1
DRE1 protein


1319.
3669
ISG20
interferon stimulated exonuclease gene 20 kDa


1320.
23710
GABARAPL1
GABA(A) receptor-associated protein like 1


1321.
400172
LOC400172
similar to KIAA1641 protein; melanoma-associated





antigen; CLL-associated antigen KW-1


1322.
153222
LOC153222
adult retina protein


1323.
54981
C9orf95
chromosome 9 open reading frame 95


1324.
5641
LGMN
legumain


1325.
257019
FRMD3
FERM domain containing 3


1326.
8357
HIST1H3H
histone 1, H3h


1327.
55281
FLJ11000
hypothetical protein FLJ11000


1328.
4050
LTB
lymphotoxin beta (TNF superfamily, member 3)


1329.
203
AK1
adenylate kinase 1


1330.
5920
RARRES3
retinoic acid receptor responder (tazarotene





induced) 3


1331.
284801
LOC284801
hypothetical protein LOC284801


1332.
150271
LOC150271
hypothetical protein LOC150271




















TABLE II







ENTREZ





GENE ID
GENE SYMBOL
GENE DESCRIPTION



















1.
6348
CCL3
chemokine (C-C motif) ligand 3


2.
55388
MCM10
MCM10 minichromosome maintenance deficient 10





(S. cerevisiae)


3.
7117
TMSL3
thymosin-like 3


4.
1017
CDK2
cyclin-dependent kinase 2


5.
79019
C22orf18
chromosome 22 open reading frame 18


6.
6241
RRM2
ribonucleotide reductase M2 polypeptide


7.
4605
MYBL2
v-myb myeloblastosis viral oncogene homolog





(avian)-like 2


8.
894
CCND2
cyclin D2


9.
57405
SPBC25
spindle pole body component 25 homolog (S. cerevisiae)


10.
146909
LOC146909
hypothetical protein LOC146909


11.
150271
LOC150271
hypothetical protein LOC150271


12.
203
AK1
adenylate kinase 1


13.
4050
LTB
lymphotoxin beta (TNF superfamily, member 3)


14.
257019
FRMD3
FERM domain containing 3


15.
8357
HIST1H3H
histone 1, H3h


16.
23710
GABARAPL1
GABA(A) receptor-associated protein like 1


17.
4171
MCM2
MCM2 minichromosome maintenance deficient 2,





mitotin (S. cerevisiae)


18.
4176
MCM7
MCM7 minichromosome maintenance deficient 7





(S. cerevisiae)


19.
29089
UBE2T
ubiquitin-conjugating enzyme E2T (putative)


20.
890
CCNA2
cyclin A2


21.
51514
DTL
denticleless homolog (Drosophila)


22.
440279
UNC13C
unc-13 homolog C (C. elegans)


23.
11130
ZWINT
ZW10 interactor


24.
9768
KIAA0101
KIAA0101


25.
27338
UBE2S
ubiquitin-conjugating enzyme E2S


26.
1846
DUSP4
dual specificity phosphatase 4


27.
9833
MELK
maternal embryonic leucine zipper kinase


28.
387103
C6orf173
chromosome 6 open reading frame 173


29.
137392
LOC137392
similar to CG6405 gene product


30.
7374
UNG
uracil-DNA glycosylase


31.
4915
NTRK2
neurotrophic tyrosine kinase, receptor, type 2


32.
990
CDC6
CDC6 cell division cycle 6 homolog (S. cerevisiae)


33.
55165
C10orf3
chromosome 10 open reading frame 3


34.
4001
LMNB1
lamin B1


35.
51659
Pfs2
DNA replication complex GINS protein PSF2


36.
11065
UBE2C
ubiquitin-conjugating enzyme E2C


37.
4174
MCM5
MCM5 minichromosome maintenance deficient 5,





cell division cycle 46 (S. cerevisiae)


38.
113130
CDCA5
cell division cycle associated 5


39.
9535
GMFG
glia maturation factor, gamma


40.
195828
ZNF367
zinc finger protein 367


41.
55355
DKFZp762E1312
hypothetical protein DKFZp762E1312


42.
9928
KIF14
kinesin family member 14


43.
83879
CDCA7
cell division cycle associated 7


44.
701
BUB1B
BUB1 budding uninhibited by benzimidazoles 1





homolog beta (yeast)


45.
200734
SPRED2
sprouty-related, EVH1 domain containing 2


46.
991
CDC20
CDC20 cell division cycle 20 homolog (S. cerevisiae)


47.
22974
TPX2
TPX2, microtubule-associated protein homolog





(Xenopus laevis)


48.
3832
KIF11
kinesin family member 11


49.
4288
MKI67
antigen identified by monoclonal antibody Ki-67


50.
983
CDC2
cell division cycle 2, G1 to S and G2 to M


51.
28231
SLCO4A1
solute carrier organic anion transporter family,





member 4A1


52.
79801
SHCBP1
SHC SH2-domain binding protein 1


53.
7804
LRP8
low density lipoprotein receptor-related protein 8,





apolipoprotein e receptor


54.
7298
TYMS
thymidylate synthetase


55.
7083
TK1
thymidine kinase 1, soluble


56.
26147
PHF19
PHD finger protein 19


57.
55839
BM039
uncharacterized bone marrow protein BM039


58.
9232
PTTG1
pituitary tumor-transforming 1


59.
10592
SMC2L1
SMC2 structural maintenance of chromosomes 2-





like 1 (yeast)


60.
3398
ID2
inhibitor of DNA binding 2, dominant negative helix-





loop-helix protein


61.
4085
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)


62.
1063
CENPF
centromere protein F, 350/400ka (mitosin)


63.
3418
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial


64.
1163
CKS1B
CDC28 protein kinase regulatory subunit 1B


65.
55215
FLJ10719
hypothetical protein FLJ10719


66.
29127
RACGAP1
Rac GTPase activating protein 1


67.
7153
TOP2A
topoisomerase (DNA) II alpha 170 kDa


68.
122769
PPIL5
peptidylprolyl isomerase (cyclophilin)-like 5


69.
79682
MLF1IP
MLF1 interacting protein


70.
6790
STK6
serine/threonine kinase 6


71.
3925
STMN1
stathmin 1/oncoprotein 18


72.
11004
KIF2C
kinesin family member 2C


73.
10276
NET1
neuroepithelial cell transforming gene 1


74.
3015
H2AFZ
H2A histone family, member Z


75.
891
CCNB1
cyclin B1


76.
389835
FAM72A
family with sequence similarity 72, member A


77.
5111
PCNA
proliferating cell nuclear antigen


78.
9837
PSF1
DNA replication complex GINS protein PSF1


79.
3148
HMGB2
high-mobility group box 2


80.
7112
TMPO
thymopoietin


81.
63901
FLJ22794
FLJ22794 protein


82.
51203
NUSAP1
nucleolar and spindle associated protein 1


83.
29128
UHRF1
ubiquitin-like, containing PHD and RING finger





domains, 1


84.
79075
DCC1
defective in sister chromatid cohesion homolog 1 (S. cerevisiae)


85.
9319
TRIP13
thyroid hormone receptor interactor 13


86.
1033
CDKN3
cyclin-dependent kinase inhibitor 3 (CDK2-





associated dual specificity phosphatase)


87.
10189
THOC4
THO complex 4


88.
9133
CCNB2
cyclin B2


89.
55010
FLJ20641
hypothetical protein FLJ20641


90.
83540
CDCA1
cell division cycle associated 1


91.
1870
E2F2
E2F transcription factor 2


92.
962
CD48
CD48 antigen (B-cell membrane protein)


93.
55789
DEPDC1B
DEP domain containing 1B


94.
170954
KIAA1949
KIAA1949


95.
332
BIRC5
baculoviral IAP repeat-containing 5 (survivin)


96.
445815
PALM2-AKAP2
PALM2-AKAP2 protein


97.
865
CBFB
core-binding factor, beta subunit


98.
7913
DEK
DEK oncogene (DNA binding)


99.
5983
RFC3
replication factor C (activator 1) 3, 38 kDa


100.
84515
MCM8
MCM8 minichromosome maintenance deficient 8





(S. cerevisiae)


101.
51053
GMNN
geminin, DNA replication inhibitor


102.
1111
CHEK1
CHK1 checkpoint homolog (S. pombe)


103.
7443
VRK1
vaccinia related kinase 1


104.
10376
K-ALPHA-1
tubulin, alpha, ubiquitous


105.
3014
H2AFX
H2A histone family, member X


106.
9055
PRC1
protein regulator of cytokinesis 1


107.
2237
FEN1
flap structure-specific endonuclease 1


108.
81563
C1orf21
chromosome 1 open reading frame 21


109.
51192
CKLF
chemokine-like factor


110.
1062
CENPE
centromere protein E, 312 kDa


111.
11339
OIP5
Opa interacting protein 5


112.
10615
SPAG5
sperm associated antigen 5


113.
55646
LYAR
hypothetical protein FLJ20425


114.
55706
TMEM48
transmembrane protein 48


115.
1058
CENPA
centromere protein A, 17 kDa


116.
3070
HELLS
helicase, lymphoid-specific


117.
4173
MCM4
MCM4 minichromosome maintenance deficient 4





(S. cerevisiae)


118.
23421
ITGB3BP
integrin beta 3 binding protein (beta3-endonexin)


119.
9530
BAG4
BCL2-associated athanogene 4


120.
801
CALM1
calmodulin 1 (phosphorylase kinase, delta)


121.
54069
C21orf45
chromosome 21 open reading frame 45


122.
283991
MGC29814
hypothetical protein MGC29814


123.
63979
FIGNL1
fidgetin-like 1


124.
64105
FKSG14
leucine zipper protein FKSG14


125.
4172
MCM3
MCM3 minichromosome maintenance deficient 3





(S. cerevisiae)


126.
24137
KIF4A
kinesin family member 4A


127.
7398
USP1
ubiquitin specific protease 1


128.
84930
MASTL
microtubule associated serine/threonine kinase-like


129.
51512
GTSE1
G-2 and S-phase expressed 1


130.
4678
NASP
nuclear autoantigenic sperm protein (histone-





binding)


131.
699
BUB1
BUB1 budding uninhibited by benzimidazoles 1





homolog (yeast)


132.
1719
DHFR
dihydrofolate reductase


133.
494143
LOC494143
similar to RIKEN cDNA 2510006C20 gene


134.
55055
FLJ10036
Zwilch


135.
672
BRCA1
breast cancer 1, early onset


136.
64946
CENPH
centromere protein H


137.
83461
CDCA3
cell division cycle associated 3


138.
7465
WEE1
WEE1 homolog (S. pombe)


139.
5984
RFC4
replication factor C (activator 1) 4, 37 kDa


140.
64581
CLEC7A
C-type lectin domain family 7, member A


141.
1230
CCR1
chemokine (C-C motif) receptor 1


142.
4175
MCM6
MCM6 minichromosome maintenance deficient 6





(MIS5 homolog, S. pombe) (S. cerevisiae)


143.
55502
HES6
hairy and enhancer of split 6 (Drosophila)


144.
64151
HCAP-G
chromosome condensation protein G


145.
11151
CORO1A
coronin, actin binding protein, 1A


146.
203068
TUBB
tubulin, beta polypeptide


147.
10926
ASK
activator of S phase kinase


148.
11073
TOPBP1
topoisomerase (DNA) II binding protein 1


149.
90417
C15orf23
chromosome 15 open reading frame 23


150.
9493
KIF23
kinesin family member 23


151.
387882
LOC387882
hypothetical protein


152.
23234
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9


153.
2146
EZH2
enhancer of zeste homolog 2 (Drosophila)


154.
6627
SNRPA1
small nuclear ribonucleoprotein polypeptide A′


155.
5982
RFC2
replication factor C (activator 1) 2, 40 kDa


156.
51155
HN1
hematological and neurological expressed 1


157.
10635
RAD51AP1
RAD51 associated protein 1


158.
91057
NY-REN-41
NY-REN-41 antigen


159.
11168
PSIP1
PC4 and SFRS1 interacting protein 1


160.
10403
KNTC2
kinetochore associated 2


161.
4751
NEK2
NIMA (never in mitosis gene a)-related kinase 2


162.
29028
ATAD2
ATPase family, AAA domain containing 2


163.
26271
FBXO5
F-box protein 5


164.
54892
LUZP5
leucine zipper protein 5


165.
79723
SUV39H2
suppressor of variegation 3-9 homolog 2





(Drosophila)


166.
23590
TPRT
trans-prenyltransferase


167.
2288
FKBP4
FK506 binding protein 4, 59 kDa


168.
23165
NUP205
nucleoporin 205 kDa


169.
6240
RRM1
ribonucleotide reductase M1 polypeptide


170.
81539
SLC38A1
solute carrier family 38, member 1


171.
1894
ECT2
epithelial cell transforming sequence 2 oncogene


172.
55872
PBK
PDZ binding kinase


173.
55635
DEPDC1
DEP domain containing 1


174.
11013
TMSL8
thymosin-like 8


175.
259266
ASPM
asp (abnormal spindle)-like, microcephaly





associated (Drosophila)


176.
10950
BTG3
BTG family, member 3


177.
56992
KIF15
kinesin family member 15


178.
29980
DONSON
downstream neighbor of SON


179.
5757
PTMA
prothymosin, alpha (gene sequence 28)


180.
5932
RBBP8
retinoblastoma binding protein 8


181.
7903
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-





sialyltransferase 4


182.
348235
FAM33A
family with sequence similarity 33, member A


183.
3182
HNRPAB
heterogeneous nuclear ribonucleoprotein A/B


184.
3161
HMMR
hyaluronan-mediated motility receptor (RHAMM)


185.
5985
RFC5
replication factor C (activator 1) 5, 36.5 kDa


186.
864
RUNX3
runt-related transcription factor 3


187.
3930
LBR
lamin B receptor


188.
1434
CSE1L
CSE1 chromosome segregation 1-like (yeast)


189.
81610
C20orf129
chromosome 20 open reading frame 129


190.
3146
HMGB1
high-mobility group box 1


191.
55636
CHD7
chromodomain helicase DNA binding protein 7


192.
54443
ANLN
anillin, actin binding protein (scraps homolog,





Drosophila)


193.
5698
PSMB9
proteasome (prosome, macropain) subunit, beta





type, 9 (large multifunctional protease 2)


194.
7277
TUBA1
tubulin, alpha 1 (testis specific)


195.
64282
PAPD5
PAP associated domain containing 5


196.
201725
LOC201725
hypothetical protein LOC201725


197.
7171
TPM4
tropomyosin 4


198.
3838
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha





1)


199.
116832
RPL39L
ribosomal protein L39-like


200.
4602
MYB
v-myb myeloblastosis viral oncogene homolog





(avian)


201.
54962
FLJ20516
timeless-interacting protein


202.
10541
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32





family, member B


203.
9787
DLG7
discs, large homolog 7 (Drosophila)


204.
147138
EVER2
epidermodysplasia verruciformis 2


205.
157313
CDCA2
cell division cycle associated 2


206.
11340
EXOSC8
exosome component 8


207.
2956
MSH6
mutS homolog 6 (E. coli)


208.
151246
SGOL2
shugoshin-like 2 (S. pombe)


209.
27346
MAC30
hypothetical protein MAC30


210.
5873
RAB27A
RAB27A, member RAS oncogene family


211.
79596
C13orf7
chromosome 13 open reading frame 7


212.
10051
SMC4L1
SMC4 structural maintenance of chromosomes 4-





like 1 (yeast)


213.
3336
HSPE1
heat shock 10 kDa protein 1 (chaperonin 10)


214.
6432
SFRS7
splicing factor, arginine/serine-rich 7, 35 kDa


215.
8819
SAP30
sin3-associated polypeptide, 30 kDa


216.
54801
FAM29A
family with sequence similarity 29, member A


217.
1123
CHN1
chimerin (chimaerin) 1


218.
694
BTG1
B-cell translocation gene 1, anti-proliferative


219.
153222
LOC153222
adult retina protein


220.
3669
ISG20
interferon stimulated exonuclease gene 20 kDa


221.
151556
GPR155
G protein-coupled receptor 155


222.
6591
SNAI2
snail homolog 2 (Drosophila)


223.
5920
RARRES3
retinoic acid receptor responder (tazarotene





induced) 3


224.
400172
LOC400172
similar to KIAA1641 protein; melanoma-associated





antigen; CLL-associated antigen KW-1


225.
55281
FLJ11000
hypothetical protein FLJ11000


226.
9783
RIMS3
regulating synaptic membrane exocytosis 3


227.
6480
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1


228.
390
RND3
Rho family GTPase 3


229.
10765
JARID1B
Jumonji, AT rich interactive domain 1B (RBP2-like)


230.
154091
SLC2A12
solute carrier family 2 (facilitated glucose





transporter), member 12


231.
54981
C9orf95
chromosome 9 open reading frame 95


232.
1663
DDX11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11





(CHL1-like helicase homolog, S. cerevisiae)


233.
54800
DRE1
DRE1 protein


234.
57515
TDE2
tumor differentially expressed 2


235.
83719
YPEL3
yippee-like 3 (Drosophila)


236.
5269
SERPINB6
serine (or cysteine) proteinase inhibitor, clade B





(ovalbumin), member 6


237.
30061
SLC40A1
solute carrier family 40 (iron-regulated transporter),





member 1


238.
5660
PSAP
prosaposin (variant Gaucher disease and variant





metachromatic leukodystrophy)


239.
51646
YPEL5
yippee-like 5 (Drosophila)


240.
145788
FLJ27352
hypothetical LOC145788


241.
81030
ZBP1
Z-DNA binding protein 1


242.
57035
C1orf63
chromosome 1 open reading frame 63


243.
9863
MAGI2
membrane associated guanylate kinase, WW and





PDZ domain containing 2


244.
9855
FARP2
FERM, RhoGEF and pleckstrin domain protein 2


245.
57612
KIAA1466
KIAA1466 gene


246.
56243
KIAA1217
KIAA1217


247.
8365
HIST1H4H
histone 1, H4h


248.
440081
DDX12
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12





(CHL1-like helicase homolog, S. cerevisiae)


249.
83937
RASSF4
Ras association (RalGDS/AF-6) domain family 4


250.
56204
FLJ10980
hypothetical protein FLJ10980


251.
22932
POMZP3
POM (POM121 homolog, rat) and ZP3 fusion


252.
10628
TXNIP
thioredoxin interacting protein


253.
6720
SREBF1
sterol regulatory element binding transcription factor 1


254.
1508
CTSB
cathepsin B


255.
84513
HTPAP
HTPAP protein


256.
85352
KIAA1644
KIAA1644 protein


257.
9388
LIPG
lipase, endothelial


258.
5163
PDK1
pyruvate dehydrogenase kinase, isoenzyme 1


259.
23446
CDW92
CDW92 antigen


260.
10156
RASA4
RAS p21 protein activator 4


261.
23766
GABARAPL3
GABA(A) receptors associated protein like 3


262.
56904
SH3GLB2
SH3-domain GRB2-like endophilin B2


263.
6609
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal





(acid sphingomyelinase)


264.
23259
DDHD2
DDHD domain containing 2


265.
23092
ARHGAP26
Rho GTPase activating protein 26


266.
27250
PDCD4
programmed cell death 4 (neoplastic transformation





inhibitor)


267.
3983
ABLIM1
actin binding LIM protein 1


268.
23461
ABCA5
ATP-binding cassette, sub-family A (ABC1),





member 5


269.
4094
MAF
v-maf musculoaponeurotic fibrosarcoma oncogene





homolog (avian)


270.
23646
PLD3
phospholipase D family, member 3


271.
51566
ARMCX3
armadillo repeat containing, X-linked 3


272.
58476
TP53INP2
tumor protein p53 inducible nuclear protein 2


273.
29994
BAZ2B
bromodomain adjacent to zinc finger domain, 2B


274.
283131
TncRNA
trophoblast-derived noncoding RNA


275.
4189
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9


276.
9123
SLC16A3
solute carrier family 16 (monocarboxylic acid





transporters), member 3


277.
8473
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase





(UDP-N-acetylglucosamine:polypeptide-N-





acetylglucosaminyl transferase)


278.
65018
PINK1
PTEN induced putative kinase 1


279.
339448
LOC339448
hypothetical protein LOC339448


280.
6513
SLC2A1
solute carrier family 2 (facilitated glucose





transporter), member 1


281.
3995
FADS3
fatty acid desaturase 3


282.
155038
GIMAP8
GTPase, IMAP family member 8


283.
90634
CG018
hypothetical gene CG018


284.
55573
H41
hypothetical protein H41


285.
9201
DCAMKL1
doublecortin and CaM kinase-like 1


286.
388403
YPEL2
yippee-like 2 (Drosophila)


287.
255631
COL24A1
collagen, type XXIV, alpha 1


288.
8440
NCK2
NCK adaptor protein 2


289.
81790
RNF170
ring finger protein 170


290.
9706
ULK2
unc-51-like kinase 2 (C. elegans)


291.
934
CD24
CD24 antigen (small cell lung carcinoma cluster 4





antigen)


292.
9532
BAG2
BCL2-associated athanogene 2


293.
23331
KIAA1043
KIAA1043 protein


294.
10675
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)


295.
1102
RCBTB2
regulator of chromosome condensation (RCC1) and





BTB (POZ) domain containing protein 2


296.
2119
ETV5
ets variant gene 5 (ets-related molecule)


297.
255488
IBRDC2
IBR domain containing 2


298.
55076
TMEM45A
transmembrane protein 45A


299.
8364
HIST1H4C
histone 1, H4c


300.
3725
JUN
v-jun sarcoma virus 17 oncogene homolog (avian)


301.
384
ARG2
arginase, type II


302.
10129
13CDNA73
hypothetical protein CG003


303.
1960
EGR3
early growth response 3


304.
27122
DKK3
dickkopf homolog 3 (Xenopus laevis)


305.
11178
LZTS1
leucine zipper, putative tumor suppressor 1


306.
143888
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2


307.
1601
DAB2
disabled homolog 2, mitogen-responsive





phosphoprotein (Drosophila)


308.
6542
SLC7A2
solute carrier family 7 (cationic amino acid





transporter, y+ system), member 2


309.
477
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 (+)





polypeptide


310.
90161
HS6ST2
heparan sulfate 6-O-sulfotransferase 2


311.
81031
SLC2A10
solute carrier family 2 (facilitated glucose





transporter), member 10


312.
56675
NRIP3
nuclear receptor interacting protein 3


313.
1958
EGR1
early growth response 1


314.
3714
JAG2
jagged 2


315.
3897
L1CAM
L1 cell adhesion molecule


316.
1488
CTBP2
C-terminal binding protein 2


317.
145173
B3GTL
beta 3-glycosyltransferase-like


318.
112399
EGLN3
egl nine homolog 3 (C. elegans)


319.
22871
NLGN1
neuroligin 1


320.
8804
CREG1
cellular repressor of E1A-stimulated genes 1


321.
401081
FLJ22763
hypothetical gene supported by AK026416


322.
25924
MYRIP
myosin VIIA and Rab interacting protein


323.
91694
FLJ23749
hypothetical protein FLJ23749


324.
56155
TEX14
testis expressed sequence 14


325.
1349
COX7B
cytochrome c oxidase subunit VIIb


326.
3695
ITGB7
integrin, beta 7


327.
1164
CKS2
CDC28 protein kinase regulatory subunit 2


328.
56919
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33


329.
3276
HRMT1L2
HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)


330.
116151
C20orf108
chromosome 20 open reading frame 108


331.
25758
G2
G2 protein


332.
25861
DFNB31
deafness, autosomal recessive 31


333.
9666
DZIP3
zinc finger DAZ interacting protein 3


334.
1486
CTBS
chitobiase, di-N-acetyl-


335.
3123
HLA-DRB1
major histocompatibility complex, class II, DR beta 1


336.
317649
EIF4E3
eukaryotic translation initiation factor 4E member 3


337.
50854
C6orf48
chromosome 6 open reading frame 48


338.
401024
FLJ44048
FLJ44048 protein


339.
114327
EFHC1
EF-hand domain (C-terminal) containing 1


340.
8334
HIST1H2AC
histone 1, H2ac


341.
284214
LOC284214
hypothetical protein LOC284214


342.
10379
ISGF3G
interferon-stimulated transcription factor 3, gamma





48 kDa


343.
113177
C19orf36
chromosome 19 open reading frame 36


344.
56951
C5orf15
chromosome 5 open reading frame 15


345.
285362
SUMF1
sulfatase modifying factor 1


346.
3490
IGFBP7
insulin-like growth factor binding protein 7


347.
1186
CLCN7
chloride channel 7


348.
582
BBS1
Bardet-Biedl syndrome 1


349.
339456
LOC339456
hypothetical protein LOC339456


350.
26115
DKFZP564D166
putative ankyrin-repeat containing protein


351.
9895
KIAA0329
KIAA0329


352.
1040
CDS1
CDP-diacylglycerol synthase (phosphatidate





cytidylyltransferase) 1


353.
117854
TRIM6
tripartite motif-containing 6


354.
3037
HAS2
hyaluronan synthase 2


355.
4821
NKX2-2
NK2 transcription factor related, locus 2(Drosophila)


356.
26298
EHF
ets homologous factor


357.
22873
DZIP1
DAZ interacting protein 1


358.
161742
SPRED1
sprouty-related, EVH1 domain containing 1


359.
10052
GJA7
gap junction protein, alpha 7, 45 kDa (connexin 45)


360.
79733
E2F8
E2F transcription factor 8


361.
10112
KIF20A
kinesin family member 20A


362.
54910
SEMA4C
sema domain, immunoglobulin domain (Ig),





transmembrane domain (TM) and short cytoplasmic





domain, (semaphorin) 4C


363.
993
CDC25A
cell division cycle 25A


364.
3683
ITGAL
integrin, alpha L (antigen CD11A (p180),





lymphocyte function-associated antigen 1; alpha





polypeptide)


365.
9355
LHX2
LIM homeobox 2


366.
5578
PRKCA
protein kinase C, alpha


367.
157570
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)


368.
10252
SPRY1
sprouty homolog 1, antagonist of FGF signaling





(Drosophila)


369.
22998
KIAA1102
KIAA1102 protein


370.
144455
E2F7
E2F transcription factor 7


371.
2115
ETV1
ets variant gene 1


372.
80144
FRAS1
Fraser syndrome 1


373.
1902
EDG2
endothelial differentiation, lysophosphatidic acid G-





protein-coupled receptor, 2


374.
148203
LOC148203
hypothetical protein LOC148203


375.
8851
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1





(p35)


376.
28951
TRIB2
tribbles homolog 2 (Drosophila)


377.
1491
CTH
cystathionase (cystathionine gamma-lyase)


378.
4281
MID1
midline 1 (Opitz/BBB syndrome)


379.
145482
ZADH1
zinc binding alcohol dehydrogenase, domain





containing 1


380.
84858
ZNF503
zinc finger protein 503


381.
55723
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)


382.
1718
DHCR24
24-dehydrocholesterol reductase


383.
1847
DUSP5
dual specificity phosphatase 5


384.
64081
MAWBP
MAWD binding protein


385.
22822
PHLDA1
pleckstrin homology-like domain, family A, member 1


386.
389831
LOC389831
hypothetical gene supported by AL713796


387.
9212
AURKB
aurora kinase B


388.
7272
TTK
TTK protein kinase


389.
84952
CGNL1
cingulin-like 1


390.
150468
FLJ40629
hypothetical protein FLJ40629


391.
23286
KIBRA
KIBRA protein


392.
29968
PSAT1
phosphoserine aminotransferase 1


393.
8864
PER2
period homolog 2 (Drosophila)


394.
4603
MYBL1
v-myb myeloblastosis viral oncogene homolog





(avian)-like 1


395.
285513
LOC285513
hypothetical protein LOC285513


396.
64919
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)


397.
83641
C10orf45
chromosome 10 open reading frame 45


398.
6659
SOX4
SRY (sex determining region Y)-box 4


399.
55964
3-Sep
septin 3


400.
80150
ASRGL1
asparaginase like 1


401.
8630
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6


402.
7004
TEAD4
TEA domain family member 4


403.
8871
SYNJ2
synaptojanin 2


404.
56935
FN5
FN5 protein


405.
51232
CRIM1
cysteine-rich motor neuron 1


406.
493861
EID3
E1A-like inhibitor of differentiation 3


407.
2983
GUCY1B3
guanylate cyclase 1, soluble, beta 3


408.
51776
ZAK
sterile alpha motif and leucine zipper containing





kinase AZK


409.
9953
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase





3B1


410.
23310
hCAP-D3
KIAA0056 protein


411.
2326
FMO1
flavin containing monooxygenase 1


412.
51063
FAM26B
family with sequence similarity 26, member B


413.
1038
CDR1
cerebellar degeneration-related protein 1, 34 kDa


414.
4325
MMP16
matrix metalloproteinase 16 (membrane-inserted)


415.
55247
NEIL3
nei endonuclease VIII-like 3 (E. coli)


416.
91607
FLJ34922
hypothetical protein FLJ34922


417.
284801
LOC284801
hypothetical protein LOC284801


418.
5641
LGMN
legumain


419.
4121
MAN1A1
mannosidase, alpha, class 1A, member 1


420.
1414
CRYBB1
crystallin, beta B1


421.
8530
CST7
cystatin F (leukocystatin)


422.
2669
GEM
GTP binding protein overexpressed in skeletal





muscle


423.
126731
C1orf96
chromosome 1 open reading frame 96


424.
26095
PTPN20
protein tyrosine phosphatase, non-receptor type 20


425.
57037
ANKMY2
ankyrin repeat and MYND domain containing 2


426.
3708
ITPR1
inositol 1,4,5-triphosphate receptor, type 1


427.
55740
ENAH
enabled homolog (Drosophila)


428.
57761
TRIB3
tribbles homolog 3 (Drosophila)


429.
6867
TACC1
transforming, acidic coiled-coil containing protein 1


430.
27115
PDE7B
phosphodiesterase 7B


431.
5361
PLXNA1
plexin A1


432.
54908
FLJ20364
hypothetical protein FLJ20364


433.
79710
MORC4
MORC family CW-type zinc finger 4


434.
399664
RKHD1
ring finger and KH domain containing 1


435.
90390
THRAP6
thyroid hormone receptor associated protein 6


436.
2767
GNA11
guanine nucleotide binding protein (G protein),





alpha 11 (Gq class)


437.
5793
PTPRG
protein tyrosine phosphatase, receptor type, G


438.
6385
SDC4
syndecan 4 (amphiglycan, ryudocan)


439.
205
AK3L1
adenylate kinase 3-like 1


440.
490
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1


441.
2026
ENO2
enolase 2 (gamma, neuronal)


442.
23046
KIF21B
kinesin family member 21B


443.
60468
BACH2
BTB and CNC homology 1, basic leucine zipper





transcription factor 2


444.
55013
FLJ20647
hypothetical protein FLJ20647


445.
256435
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-





galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-





sialyltransferase 3


446.
6611
SMS
spermine synthase


447.
79037
MGC2463
hypothetical protein MGC2463


448.
23279
NUP160
nucleoporin 160 kDa


449.
10160
FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain





protein 1 (chondrocyte-derived)


450.
6877
TAF5
TAF5 RNA polymerase II, TATA box binding protein





(TBP)-associated factor, 100 kDa


451.
2534
FYN
FYN oncogene related to SRC, FGR, YES


452.
23531
MMD
monocyte to macrophage differentiation-associated


453.
79621
FLJ11712
hypothetical protein FLJ11712


454.
29899
GPSM2
G-protein signalling modulator 2 (AGS3-like, C. elegans)


455.
53354
PANK1
pantothenate kinase 1


456.
2047
EPHB1
EPH receptor B1


457.
6558
SLC12A2
solute carrier family 12 (sodium/potassium/chloride





transporters), member 2


458.
8502
PKP4
plakophilin 4


459.
116496
C1orf24
chromosome 1 open reading frame 24


460.
84314
MGC10744
hypothetical protein MGC10744


461.
54830
FLJ20130
hypothetical protein FLJ20130


462.
10602
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3


463.
55257
C20orf20
chromosome 20 open reading frame 20


464.
4885
NPTX2
neuronal pentraxin II


465.
8317
CDC7
CDC7 cell division cycle 7 (S. cerevisiae)


466.
55816
DOK5
docking protein 5


467.
83732
RIOK1
RIO kinase 1 (yeast)


468.
489
ATP2A3
ATPase, Ca++ transporting, ubiquitous


469.
83990
BRIP1
BRCA1 interacting protein C-terminal helicase 1


470.
9295
SFRS11
splicing factor, arginine/serine-rich 11


471.
55166
C6orf139
chromosome 6 open reading frame 139


472.
119467
MGC32871
hypothetical protein MGC32871


473.
54101
RIPK4
receptor-interacting serine-threonine kinase 4


474.
241
ALOX5AP
arachidonate 5-lipoxygenase-activating protein


475.
2104
ESRRG
estrogen-related receptor gamma


476.
6574
SLC20A1
solute carrier family 20 (phosphate transporter),





member 1


477.
960
CD44
CD44 antigen (homing function and Indian blood





group system)


478.
26031
OSBPL3
oxysterol binding protein-like 3


479.
23636
NUP62
nucleoporin 62 kDa


480.
9448
MAP4K4
mitogen-activated protein kinase kinase kinase





kinase 4


481.
26084
SGEF
Src homology 3 domain-containing guanine





nucleotide exchange factor


482.
9735
KNTC1
kinetochore associated 1


483.
84803
MGC11324
hypothetical protein MGC11324


484.
81839
VANGL1
vang-like 1 (van gogh, Drosophila)


485.
9734
HDAC9
histone deacetylase 9


486.
51703
ACSL5
acyl-CoA synthetase long-chain family member 5


487.
10155
TRIM28
tripartite motif-containing 28


488.
54566
EPB41L4B
erythrocyte membrane protein band 4.1 like 4B


489.
10019
LNK
lymphocyte adaptor protein


490.
4082
MARCKS
myristoylated alanine-rich protein kinase C





substrate


491.
23012
STK38L
serine/threonine kinase 38 like


492.
9759
HDAC4
histone deacetylase 4


493.
657
BMPR1A
bone morphogenetic protein receptor, type IA


494.
22837
COBLL1
COBL-like 1


495.
79888
FLJ12443
hypothetical protein FLJ12443


496.
79154
MGC4172
short-chain dehydrogenase/reductase


497.
4076
M11S1
membrane component, chromosome 11, surface





marker 1


498.
79930
DOK3
docking protein 3


499.
4086
SMAD1
SMAD, mothers against DPP homolog 1





(Drosophila)


500.
79180
EFHD2
EF hand domain family, member D2


501.
6340
SCNN1G
sodium channel, nonvoltage-gated 1, gamma


502.
51015
ISOC1
isochorismatase domain containing 1


503.
6999
TDO2
tryptophan 2,3-dioxygenase


504.
55276
PGM2
phosphoglucomutase 2


505.
55270
NUDT15
nudix (nucleoside diphosphate linked moiety X)-type





motif 15


506.
51174
TUBD1
tubulin, delta 1


507.
1789
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta


508.
84451
KIAA1804
mixed lineage kinase 4


509.
5036
PA2G4
proliferation-associated 2G4, 38 kDa


510.
11177
BAZ1A
bromodomain adjacent to zinc finger domain, 1A


511.
158563
LOC158563
hypothetical protein LOC158563


512.
4957
ODF2
outer dense fiber of sperm tails 2


513.
89891
WDR34
WD repeat domain 34


514.
4640
MYO1A
myosin IA


515.
26018
LRIG1
leucine-rich repeats and immunoglobulin-like





domains 1


516.
9738
CP110
CP110 protein


517.
378708
APITD1
apoptosis-inducing, TAF9-like domain 1


518.
56952
PRTFDC1
phosphoribosyl transferase domain containing 1


519.
3099
HK2
hexokinase 2


520.
200894
ARL2L1
ADP-ribosylation factor-like 2-like 1


521.
10625
IVNS1ABP
influenza virus NS1A binding protein


522.
10436
C2F
C2f protein


523.
79038
ZFYVE21
zinc finger, FYVE domain containing 21


524.
7091
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog,





Drosophila)


525.
7291
TWIST1
twist homolog 1 (acrocephalosyndactyly 3; Saethre-





Chotzen syndrome) (Drosophila)


526.
87
ACTN1
actinin, alpha 1


527.
1736
DKC1
dyskeratosis congenita 1, dyskerin


528.
10265
IRX5
iroquois homeobox protein 5


529.
8553
BHLHB2
basic helix-loop-helix domain containing, class B, 2


530.
54947
FLJ20481
hypothetical protein FLJ20481


531.
5150
PDE7A
phosphodiesterase 7A


532.
83857
ARG99
ARG99 protein


533.
7791
ZYX
zyxin


534.
27131
SNX5
sorting nexin 5


535.
9112
MTA1
metastasis associated 1


536.
80014
BOMB
BH3-only member B protein


537.
139886
LOC139886
hypothetical protein LOC139886


538.
3189
HNRPH3
heterogeneous nuclear ribonucleoprotein H3 (2H9)


539.
56905
DKFZP434H132
DKFZP434H132 protein


540.
10838
ZNF275
zinc finger protein 275


541.
11118
BTN3A2
butyrophilin, subfamily 3, member A2


542.
401505
C9orf105
chromosome 9 open reading frame 105


543.
10384
BTN3A3
butyrophilin, subfamily 3, member A3


544.
8566
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase


545.
10098
TSPAN5
tetraspanin 5


546.
6526
SLC5A3
solute carrier family 5 (inositol transporters),





member 3


547.
6711
SPTBN1
spectrin, beta, non-erythrocytic 1


548.
26010
DNAPTP6
DNA polymerase-transactivated protein 6


549.
84108
PCGF6
polycomb group ring finger 6


550.
51444
RNF138
ring finger protein 138


551.
23089
PEG10
paternally expressed 10


552.
22995
Cep152
KIAA0912 protein


553.
1503
CTPS
CTP synthase


554.
6302
SAS
sarcoma amplified sequence


555.
3956
LGALS1
lectin, galactoside-binding, soluble, 1 (galectin 1)


556.
126823
KARCA1
kelch/ankyrin repeat containing cyclin A1 interacting





protein


557.
8605
PLA2G4C
phospholipase A2, group IVC (cytosolic, calcium-





independent)


558.
84981
MGC14376
hypothetical protein MGC14376


559.
9120
SLC16A6
solute carrier family 16 (monocarboxylic acid





transporters), member 6


560.
5816
PVALB
parvalbumin


561.
115294
LOC115294
similar to hypothetical protein FLJ10883


562.
8996
NOL3
nucleolar protein 3 (apoptosis repressor with CARD





domain)


563.
3055
HCK
hemopoietic cell kinase


564.
339803
LOC339803
hypothetical protein LOC339803


565.
252839
TMEM9
transmembrane protein 9


566.
2982
GUCY1A3
guanylate cyclase 1, soluble, alpha 3


567.
706
BZRP
benzodiazapine receptor (peripheral)


568.
5797
PTPRM
protein tyrosine phosphatase, receptor type, M


569.
9961
MVP
major vault protein


570.
999
CDH1
cadherin 1, type 1, E-cadherin (epithelial)


571.
2537
G1P3
interferon, alpha-inducible protein (clone IFI-6-16)


572.
94103
ORMDL3
ORM1-like 3 (S. cerevisiae)


573.
8337
HIST2H2AA
histone 2, H2aa


574.
10057
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP),





member 5


575.
5274
SERPINI1
serine (or cysteine) proteinase inhibitor, clade I





(neuroserpin), member 1


576.
3358
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C


577.
158158
RASEF
RAS and EF hand domain containing


578.
304
ANXA2P2
annexin A2 pseudogene 2


579.
7259
TSPYL1
TSPY-like 1


580.
8878
SQSTM1
sequestosome 1


581.
7494
XBP1
X-box binding protein 1


582.
302
ANXA2
annexin A2


583.
4864
NPC1
Niemann-Pick disease, type C1


584.
8780
RIOK3
RIO kinase 3 (yeast)


585.
27319
BHLHB5
basic helix-loop-helix domain containing, class B, 5


586.
55827
IQWD1
IQ motif and WD repeats 1


587.
966
CD59
CD59 antigen p18-20 (antigen identified by





monoclonal antibodies 16.3A5, EJ16, EJ30, EL32





and G344)


588.
55830
GLT8D1
glycosyltransferase 8 domain containing 1


589.
25934
NIPSNAP3A
nipsnap homolog 3A (C. elegans)


590.
9451
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3


591.
80267
C1orf22
chromosome 1 open reading frame 22


592.
754
PTTG1IP
pituitary tumor-transforming 1 interacting protein


593.
9236
CCPG1
cell cycle progression 1


594.
6773
STAT2
signal transducer and activator of transcription 2,





113 kDa


595.
90701
SEC11L3
SEC11-like 3 (S. cerevisiae)


596.
2590
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide





N-acetylgalactosaminyltransferase 2 (GalNac-T2)


597.
25976
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase


598.
57674
C17orf27
chromosome 17 open reading frame 27


599.
7844
RNF103
ring finger protein 103


600.
93953
ACRC
acidic repeat containing


601.
6990
TCTE1L
t-complex-associated-testis-expressed 1-like


602.
571
BACH1
BTB and CNC homology 1, basic leucine zipper





transcription factor 1


603.
6672
SP100
nuclear antigen Sp100


604.
2799
GNS
glucosamine (N-acetyl)-6-sulfatase (Sanfilippo





disease IIID)


605.
10550
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5


606.
79738
FLJ23560
hypothetical protein FLJ23560


607.
54059
C21orf57
chromosome 21 open reading frame 57


608.
3275
HRMT1L1
HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)


609.
51706
NQO3A2
NAD(P)H:quinone oxidoreductase type 3,





polypeptide A2


610.
79158
MGC4170
MGC4170 protein


611.
80315
CPEB4
cytoplasmic polyadenylation element binding protein 4


612.
3981
LIG4
ligase IV, DNA, ATP-dependent


613.
1299
COL9A3
collagen, type IX, alpha 3


614.
3572
IL6ST
interleukin 6 signal transducer (gp130, oncostatin M





receptor)


615.
107
ADCY1
adenylate cyclase 1 (brain)


616.
84181
CHD6
chromodomain helicase DNA binding protein 6


617.
54431
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10


618.
283846
DKFZp547E087
PI-3-kinase-related kinase SMG-1-like


619.
25796
PGLS
6-phosphogluconolactonase


620.
5800
PTPRO
protein tyrosine phosphatase, receptor type, O


621.
5476
PPGB
protective protein for beta-galactosidase





(galactosialidosis)


622.
54885
FLJ20298
FLJ20298 protein


623.
1368
CPM
carboxypeptidase M


624.
586
BCAT1
branched chain aminotransferase 1, cytosolic


625.
130271
PLEKHH2
pleckstrin homology domain containing, family H





(with MyTH4 domain) member 2


626.
81930
KIF18A
kinesin family member 18A


627.
11096
ADAMTS5
a disintegrin-like and metalloprotease (reprolysin





type) with thrombospondin type 1 motif, 5





(aggrecanase-2)


628.
4148
MATN3
matrilin 3


629.
56121
PCDHB15
protocadherin beta 15


630.
57552
AADACL1
arylacetamide deacetylase-like 1


631.
64396
GMCL1L
germ cell-less homolog 1 (Drosophila)-like


632.
3119
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1


633.
1827
DSCR1
Down syndrome critical region gene 1


634.
3202
HOXA5
homeo box A5


635.
3298
HSF2
heat shock transcription factor 2


636.
387914
TMEM46
transmembrane protein 46


637.
11169
WDHD1
WD repeat and HMG-box DNA binding protein 1


638.
79899
FLJ14213
hypothetical protein FLJ14213


639.
1400
CRMP1
collapsin response mediator protein 1


640.
55117
SLC6A15
solute carrier family 6, member 15


641.
134429
STARD4
START domain containing 4, sterol regulated


642.
253832
ZDHHC20
zinc finger, DHHC-type containing 20


643.
84986
ARHGAP19
Rho GTPase activating protein 19


644.
5050
PAFAH1B3
platelet-activating factor acetylhydrolase, isoform lb,





gamma subunit 29 kDa


645.
4208
MEF2C
MADS box transcription enhancer factor 2,





polypeptide C (myocyte enhancer factor 2C)


646.
9994
CASP8AP2
CASP8 associated protein 2


647.
5634
PRPS2
phosphoribosyl pyrophosphate synthetase 2


648.
23587
DERP6
S-phase 2 protein


649.
57685
KIAA1573
KIAA1573 protein


650.
57530
CGN
cingulin


651.
1633
DCK
deoxycytidine kinase


652.
24147
FJX1
four jointed box 1 (Drosophila)


653.
9882
TBC1D4
TBC1 domain family, member 4


654.
55183
RIF1
RAP1 interacting factor homolog (yeast)


655.
221362
LOC221362
hypothetical protein LOC221362


656.
5569
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor





alpha


657.
6891
TAP2
transporter 2, ATP-binding cassette, sub-family B





(MDR/TAP)


658.
11252
PACSIN2
protein kinase C and casein kinase substrate in





neurons 2


659.
81575
DKFZP434F0318
hypothetical protein DKFZp434F0318


660.
56906
THAP10
THAP domain containing 10


661.
55110
FLJ10292
mago-nashi homolog


662.
9612
NCOR2
nuclear receptor co-repressor 2


663.
257415
MGC40405
hypothetical protein MGC40405


664.
160897
ITR
intimal thickness-related receptor


665.
4668
NAGA
N-acetylgalactosaminidase, alpha-


666.
84890
C10orf22
chromosome 10 open reading frame 22


667.
2618
GART
phosphoribosylglycinamide formyltransferase,





phosphoribosylglycinamide synthetase,





phosphoribosylaminoimidazole synthetase


668.
80210
FLJ12584
melanoma/melanocyte specific protein KU-MEL-1


669.
57534
MIB1
mindbomb homolog 1 (Drosophila)


670.
56122
PCDHB14
protocadherin beta 14


671.
10966
RAB40B
RAB40B, member RAS oncogene family


672.
5095
PCCA
propionyl Coenzyme A carboxylase, alpha





polypeptide


673.
55857
C20orf19
chromosome 20 open reading frame 19


674.
285464
FLJ34443
hypothetical protein FLJ34443


675.
1509
CTSD
cathepsin D (lysosomal aspartyl protease)


676.
91614
LOC91614
novel 58.3 KDA protein


677.
2200
FBN1
fibrillin 1 (Marfan syndrome)


678.
6347
CCL2
chemokine (C-C motif) ligand 2


679.
2743
GLRB
glycine receptor, beta


680.
116448
OLIG1
oligodendrocyte transcription factor 1


681.
3613
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2


682.
6764
ST5
suppression of tumorigenicity 5


683.
4137
MAPT
microtubule-associated protein tau


684.
9099
USP2
ubiquitin specific protease 2


685.
5777
PTPN6
protein tyrosine phosphatase, non-receptor type 6


686.
59338
PLEKHA1
pleckstrin homology domain containing, family A





(phosphoinositide binding specific) member 1


687.
1028
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)


688.
2177
FANCD2
Fanconi anemia, complementation group D2


689.
165055
FLJ32745
hypothetical protein FLJ32745


690.
151827
LRRC34
leucine rich repeat containing 34


691.
203562
TMEM31
transmembrane protein 31


692.
6934
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-





box)


693.
5577
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II,





beta


694.
79442
LRRC2
leucine rich repeat containing 2


695.
55366
LGR4
leucine-rich repeat-containing G protein-coupled





receptor 4


696.
7975
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene





homolog K (avian)


697.
340252
ZNF680
zinc finger protein 680


698.
22800
RRAS2
related RAS viral (r-ras) oncogene homolog 2


699.
2730
GCLM
glutamate-cysteine ligase, modifier subunit


700.
29841
GRHL1
grainyhead-like 1 (Drosophila)


701.
9214
FAIM3
Fas apoptotic inhibitory molecule 3


702.
57406
ABHD6
abhydrolase domain containing 6


703.
4660
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit





12B


704.
157503
LOC157503
hypothetical protein LOC157503


705.
285704
RGMB
RGM domain family, member B


706.
55614
C20orf23
chromosome 20 open reading frame 23


707.
85463
ZC3H12C
zinc finger CCCH-type containing 12C


708.
6470
SHMT1
serine hydroxymethyltransferase 1 (soluble)


709.
9397
NMT2
N-myristoyltransferase 2


710.
201161
PRR6
proline rich 6


711.
8564
KMO
kynurenine 3-monooxygenase (kynurenine 3-





hydroxylase)


712.
283824
LOC283824
hypothetical protein LOC283824


713.
57522
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1


714.
79695
GALNT12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide





N-acetylgalactosaminyltransferase 12 (GalNAc-T12)


715.
396
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha


716.
9208
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1


717.
6453
ITSN1
intersectin 1 (SH3 domain protein)


718.
169200
DKFZp762C1112
hypothetical protein DKFZp762C1112


719.
9331
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4-





galactosyltransferase, polypeptide 6


720.
8458
TTF2
transcription termination factor, RNA polymerase II


721.
1047
CLGN
calmegin


722.
93949
CXorf10
chromosome X open reading frame 10


723.
51762
RAB8B
RAB8B, member RAS oncogene family


724.
5267
SERPINA4
serine (or cysteine) proteinase inhibitor, clade A





(alpha-1 antiproteinase, antitrypsin), member 4


725.
1844
DUSP2
dual specificity phosphatase 2


726.
79720
FLJ12750
hypothetical protein FLJ12750


727.
4522
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+





dependent) 1, methenyltetrahydrofolate





cyclohydrolase, formyltetrahydrofolate synthetase


728.
5198
PFAS
phosphoribosylformylglycinamidine synthase (FGAR





amidotransferase)


729.
55544
RNPC1
RNA-binding region (RNP1, RRM) containing 1


730.
9261
MAPKAPK2
mitogen-activated protein kinase-activated protein





kinase 2


731.
285761
DCBLD1
discoidin, CUB and LCCL domain containing 1


732.
161527
LOC161527
hypothetical protein LOC161527


733.
8548
BLZF1
basic leucine zipper nuclear factor 1 (JEM-1)


734.
10537
UBD
ubiquitin D


735.
64224
FLJ22313
hypothetical protein FLJ22313


736.
4637
MYL6
myosin, light polypeptide 6, alkali, smooth muscle





and non-muscle


737.
51569
UFM1
ubiquitin-fold modifier 1


738.
57599
WDR48
WD repeat domain 48


739.
57162
PELI1
pellino homolog 1 (Drosophila)


740.
58486
LOC58486
transposon-derived Buster1 transposase-like protein





gene


741.
1266
CNN3
calponin 3, acidic




















TABLE III







ENTREZ





GENE ID
GENE SYMBOL
GENE DESCRIPTION



















1.
6348
CCL3
chemokine (C-C motif) ligand 3


2.
55388
MCM10
MCM10 minichromosome maintenance deficient 10





(S. cerevisiae)


3.
7117
TMSL3
thymosin-like 3


4.
1017
CDK2
cyclin-dependent kinase 2


5.
79019
C22orf18
chromosome 22 open reading frame 18


6.
6241
RRM2
ribonucleotide reductase M2 polypeptide


7.
4605
MYBL2
v-myb myeloblastosis viral oncogene homolog





(avian)-like 2


8.
894
CCND2
cyclin D2


9.
57405
SPBC25
spindle pole body component 25 homolog (S. cerevisiae)


10.
146909
LOC146909
hypothetical protein LOC146909


11.
150271
LOC150271
hypothetical protein LOC150271


12.
203
AK1
adenylate kinase 1


13.
4050
LTB
lymphotoxin beta (TNF superfamily, member 3)


14.
257019
FRMD3
FERM domain containing 3


15.
8357
HIST1H3H
histone 1, H3h


16.
23710
GABARAPL1
GABA(A) receptor-associated protein like 1


17.
9201
DCAMKL1
doublecortin and CaM kinase-like 1


18.
934
CD24
CD24 antigen (small cell lung carcinoma cluster 4





antigen)


19.
9532
BAG2
BCL2-associated athanogene 2


20.
23331
KIAA1043
KIAA1043 protein


21.
10675
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)


22.
1102
RCBTB2
regulator of chromosome condensation (RCC1) and





BTB (POZ) domain containing protein 2


23.
2119
ETV5
ets variant gene 5 (ets-related molecule)


24.
255488
IBRDC2
IBR domain containing 2


25.
55076
TMEM45A
transmembrane protein 45A


26.
8364
HIST1H4C
histone 1, H4c


27.
3725
JUN
v-jun sarcoma virus 17 oncogene homolog (avian)


28.
384
ARG2
arginase, type II


29.
10129
13CDNA73
hypothetical protein CG003


30.
1960
EGR3
early growth response 3


31.
27122
DKK3
dickkopf homolog 3 (Xenopus laevis)


32.
11178
LZTS1
leucine zipper, putative tumor suppressor 1


33.
143888
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2


34.
1601
DAB2
disabled homolog 2, mitogen-responsive





phosphoprotein (Drosophila)


35.
6542
SLC7A2
solute carrier family 7 (cationic amino acid





transporter, y+ system), member 2


36.
477
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 (+)





polypeptide


37.
90161
HS6ST2
heparan sulfate 6-O-sulfotransferase 2


38.
81031
SLC2A10
solute carrier family 2 (facilitated glucose





transporter), member 10


39.
56675
NRIP3
nuclear receptor interacting protein 3


40.
1958
EGR1
early growth response 1


41.
3714
JAG2
jagged 2


42.
3897
L1CAM
L1 cell adhesion molecule


43.
1488
CTBP2
C-terminal binding protein 2


44.
145173
B3GTL
beta 3-glycosyltransferase-like


45.
112399
EGLN3
egl nine homolog 3 (C. elegans)


46.
22871
NLGN1
neuroligin 1


47.
8804
CREG1
cellular repressor of E1A-stimulated genes 1


48.
117854
TRIM6
tripartite motif-containing 6


49.
3037
HAS2
hyaluronan synthase 2


50.
4821
NKX2-2
NK2 transcription factor related, locus 2





(Drosophila)


51.
26298
EHF
ets homologous factor


52.
22873
DZIP1
DAZ interacting protein 1


53.
161742
SPRED1
sprouty-related, EVH1 domain containing 1


54.
10052
GJA7
gap junction protein, alpha 7, 45 kDa (connexin 45)


55.
79733
E2F8
E2F transcription factor 8


56.
10112
KIF20A
kinesin family member 20A


57.
54910
SEMA4C
sema domain, immunoglobulin domain (Ig),





transmemebrane domain (TM) and short cytoplasmic





domain, (semaphorin) 4C


58.
993
CDC25A
cell division cycle 25A


59.
3683
ITGAL
integrin, alpha L (antigen CD11A (p180),





lymphocyte function-associated antigen 1; alpha





polypeptide)


60.
9355
LHX2
LIM homeobox 2


61.
5578
PRKCA
protein kinase C, alpha


62.
157570
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)


63.
10252
SPRY1
sprouty homolog 1, antagonist of FGF signaling





(Drosophila)


64.
22998
KIAA1102
KIAA1102 protein


65.
144455
E2F7
E2F transcription factor 7


66.
2115
ETV1
ets variant gene 1


67.
80144
FRAS1
Fraser syndrome 1


68.
1902
EDG2
endothelial differentiation, lysophosphatidic acid G-





protein-coupled receptor, 2


69.
148203
LOC148203
hypothetical protein LOC148203


70.
8851
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1





(p35)


71.
28951
TRIB2
tribbles homolog 2 (Drosophila)


72.
1491
CTH
cystathionase (cystathionine gamma-lyase)


73.
4281
MID1
midline 1 (Opitz/BBB syndrome)


74.
145482
ZADH1
zinc binding alcohol dehydrogenase, domain





containing 1


75.
84858
ZNF503
zinc finger protein 503


76.
55723
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)


77.
1718
DHCR24
24-dehydrocholesterol reductase


78.
1847
DUSP5
dual specificity phosphatase 5


79.
64081
MAWBP
MAWD binding protein


80.
22822
PHLDA1
pleckstrin homology-like domain, family A, member 1


81.
389831
LOC389831
hypothetical gene supported by AL713796


82.
9212
AURKB
aurora kinase B


83.
7272
TTK
TTK protein kinase


84.
84952
CGNL1
cingulin-like 1


85.
150468
FLJ40629
hypothetical protein FLJ40629


86.
23286
KIBRA
KIBRA protein


87.
29968
PSAT1
phosphoserine aminotransferase 1


88.
8864
PER2
period homolog 2 (Drosophila)


89.
4603
MYBL1
v-myb myeloblastosis viral oncogene homolog





(avian)-like 1


90.
285513
LOC285513
hypothetical protein LOC285513


91.
64919
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)


92.
83641
C10orf45
chromosome 10 open reading frame 45


93.
6659
SOX4
SRY (sex determining region Y)-box 4


94.
55964
3-Sep
septin 3


95.
80150
ASRGL1
asparaginase like 1


96.
8630
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6


97.
7004
TEAD4
TEA domain family member 4


98.
8871
SYNJ2
synaptojanin 2


99.
56935
FN5
FN5 protein


100.
51232
CRIM1
cysteine-rich motor neuron 1


101.
493861
EID3
E1A-like inhibitor of differentiation 3


102.
2983
GUCY1B3
guanylate cyclase 1, soluble, beta 3


103.
51776
ZAK
sterile alpha motif and leucine zipper containing





kinase AZK


104.
9953
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase





3B1


105.
23310
hCAP-D3
KIAA0056 protein


106.
2326
FMO1
flavin containing monooxygenase 1


107.
51063
FAM26B
family with sequence similarity 26, member B


108.
1038
CDR1
cerebellar degeneration-related protein 1, 34 kDa


109.
4325
MMP16
matrix metalloproteinase 16 (membrane-inserted)


110.
55247
NEIL3
nei endonuclease VIII-like 3 (E. coli)


111.
91607
FLJ34922
hypothetical protein FLJ34922


112.
284801
LOC284801
hypothetical protein LOC284801


113.
5641
LGMN
legumain


114.
4121
MAN1A1
mannosidase, alpha, class 1A, member 1


115.
1414
CRYBB1
crystallin, beta B1


116.
54885
FLJ20298
FLJ20298 protein


117.
1368
CPM
carboxypeptidase M


118.
586
BCAT1
branched chain aminotransferase 1, cytosolic


119.
130271
PLEKHH2
pleckstrin homology domain containing, family H





(with MyTH4 domain) member 2


120.
81930
KIF18A
kinesin family member 18A


121.
11096
ADAMTS5
a disintegrin-like and metalloprotease (reprolysin





type) with thrombospondin type 1 motif, 5





(aggrecanase-2)


122.
4148
MATN3
matrilin 3


123.
56121
PCDHB15
protocadherin beta 15


124.
57552
AADACL1
arylacetamide deacetylase-like 1


125.
91614
LOC91614
novel 58.3 KDA protein


126.
2200
FBN1
fibrillin 1 (Marfan syndrome)


127.
6347
CCL2
chemokine (C-C motif) ligand 2


128.
2743
GLRB
glycine receptor, beta


129.
116448
OLIG1
oligodendrocyte transcription factor 1


130.
3613
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2


131.
6764
ST5
suppression of tumorigenicity 5


132.
4137
MAPT
microtubule-associated protein tau


133.
9099
USP2
ubiquitin specific protease 2


134.
5777
PTPN6
protein tyrosine phosphatase, non-receptor type 6


135.
59338
PLEKHA1
pleckstrin homology domain containing, family A





(phosphoinositide binding specific) member 1


136.
1028
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)




















TABLE IV







ENTREZ





GENE ID
GENE SYMBOL
GENE DESCRIPTION



















1.
6348
CCL3
chemokine (C-C motif) ligand 3


2.
55388
MCM10
MCM10 minichromosome maintenance deficient 10





(S. cerevisiae)


3.
7117
TMSL3
thymosin-like 3


4.
1017
CDK2
cyclin-dependent kinase 2


5.
79019
C22orf18
chromosome 22 open reading frame 18


6.
6241
RRM2
ribonucleotide reductase M2 polypeptide


7.
4605
MYBL2
v-myb myeloblastosis viral oncogene homolog





(avian)-like 2


8.
894
CCND2
cyclin D2


9.
57405
SPBC25
spindle pole body component 25 homolog (S. cerevisiae)


10.
146909
LOC146909
hypothetical protein LOC146909


11.
150271
LOC150271
hypothetical protein LOC150271


12.
203
AK1
adenylate kinase 1


13.
4050
LTB
lymphotoxin beta (TNF superfamily, member 3)


14.
257019
FRMD3
FERM domain containing 3


15.
8357
HIST1H3H
histone 1, H3h


16.
23710
GABARAPL1
GABA(A) receptor-associated protein like 1


17.
4171
MCM2
MCM2 minichromosome maintenance deficient 2,





mitotin (S. cerevisiae)


18.
4176
MCM7
MCM7 minichromosome maintenance deficient 7





(S. cerevisiae)


19.
29089
UBE2T
ubiquitin-conjugating enzyme E2T (putative)


20.
890
CCNA2
cyclin A2


21.
51514
DTL
denticleless homolog (Drosophila)


22.
440279
UNC13C
unc-13 homolog C (C. elegans)


23.
11130
ZWINT
ZW10 interactor


24.
9768
KIAA0101
KIAA0101


25.
27338
UBE2S
ubiquitin-conjugating enzyme E2S


26.
1846
DUSP4
dual specificity phosphatase 4


27.
9833
MELK
maternal embryonic leucine zipper kinase


28.
387103
C6orf173
chromosome 6 open reading frame 173


29.
137392
LOC137392
similar to CG6405 gene product


30.
7374
UNG
uracil-DNA glycosylase


31.
4915
NTRK2
neurotrophic tyrosine kinase, receptor, type 2


32.
990
CDC6
CDC6 cell division cycle 6 homolog (S. cerevisiae)


33.
55165
C10orf3
chromosome 10 open reading frame 3


34.
4001
LMNB1
lamin B1


35.
51659
Pfs2
DNA replication complex GINS protein PSF2


36.
11065
UBE2C
ubiquitin-conjugating enzyme E2C


37.
4174
MCM5
MCM5 minichromosome maintenance deficient 5,





cell division cycle 46 (S. cerevisiae)


38.
113130
CDCA5
cell division cycle associated 5


39.
9535
GMFG
glia maturation factor, gamma


40.
195828
ZNF367
zinc finger protein 367


41.
55355
DKFZp762E1312
hypothetical protein DKFZp762E1312


42.
9928
KIF14
kinesin family member 14


43.
83879
CDCA7
cell division cycle associated 7


44.
701
BUB1B
BUB1 budding uninhibited by benzimidazoles 1





homolog beta (yeast)


45.
200734
SPRED2
sprouty-related, EVH1 domain containing 2


46.
991
CDC20
CDC20 cell division cycle 20 homolog (S. cerevisiae)


47.
22974
TPX2
TPX2, microtubule-associated protein homolog





(Xenopus laevis)


48.
3832
KIF11
kinesin family member 11


49.
4288
MKI67
antigen identified by monoclonal antibody Ki-67


50.
983
CDC2
cell division cycle 2, G1 to S and G2 to M


51.
28231
SLCO4A1
solute carrier organic anion transporter family,





member 4A1


52.
79801
SHCBP1
SHC SH2-domain binding protein 1


53.
7804
LRP8
low density lipoprotein receptor-related protein 8,





apolipoprotein e receptor


54.
7298
TYMS
thymidylate synthetase


55.
7083
TK1
thymidine kinase 1, soluble


56.
26147
PHF19
PHD finger protein 19


57.
55839
BM039
uncharacterized bone marrow protein BM039


58.
9232
PTTG1
pituitary tumor-transforming 1


59.
10592
SMC2L1
SMC2 structural maintenance of chromosomes 2-





like 1 (yeast)


60.
3398
ID2
inhibitor of DNA binding 2, dominant negative helix-





loop-helix protein


61.
4085
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)


62.
1063
CENPF
centromere protein F, 350/400ka (mitosin)


63.
3418
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial


64.
1163
CKS1B
CDC28 protein kinase regulatory subunit 1B


65.
55215
FLJ10719
hypothetical protein FLJ10719


66.
29127
RACGAP1
Rac GTPase activating protein 1


67.
7153
TOP2A
topoisomerase (DNA) II alpha 170 kDa


68.
122769
PPIL5
peptidylprolyl isomerase (cyclophilin)-like 5


69.
79682
MLF1IP
MLF1 interacting protein


70.
6790
STK6
serine/threonine kinase 6


71.
3925
STMN1
stathmin 1/oncoprotein 18


72.
11004
KIF2C
kinesin family member 2C


73.
10276
NET1
neuroepithelial cell transforming gene 1


74.
3015
H2AFZ
H2A histone family, member Z


75.
891
CCNB1
cyclin B1


76.
389835
FAM72A
family with sequence similarity 72, member A


77.
5111
PCNA
proliferating cell nuclear antigen


78.
9837
PSF1
DNA replication complex GINS protein PSF1


79.
3148
HMGB2
high-mobility group box 2


80.
7112
TMPO
thymopoietin


81.
63901
FLJ22794
FLJ22794 protein


82.
51203
NUSAP1
nucleolar and spindle associated protein 1


83.
29128
UHRF1
ubiquitin-like, containing PHD and RING finger





domains, 1


84.
79075
DCC1
defective in sister chromatid cohesion homolog 1 (S. cerevisiae)


85.
9319
TRIP13
thyroid hormone receptor interactor 13


86.
1033
CDKN3
cyclin-dependent kinase inhibitor 3 (CDK2-





associated dual specificity phosphatase)


87.
10189
THOC4
THO complex 4


88.
9133
CCNB2
cyclin B2


89.
55010
FLJ20641
hypothetical protein FLJ20641


90.
83540
CDCA1
cell division cycle associated 1


91.
1870
E2F2
E2F transcription factor 2


92.
962
CD48
CD48 antigen (B-cell membrane protein)


93.
55789
DEPDC1B
DEP domain containing 1B


94.
170954
KIAA1949
KIAA1949


95.
332
BIRC5
baculoviral IAP repeat-containing 5 (survivin)


96.
445815
PALM2-AKAP2
PALM2-AKAP2 protein


97.
865
CBFB
core-binding factor, beta subunit


98.
7913
DEK
DEK oncogene (DNA binding)


99.
5983
RFC3
replication factor C (activator 1) 3, 38 kDa


100.
84515
MCM8
MCM8 minichromosome maintenance deficient 8





(S. cerevisiae)


101.
51053
GMNN
geminin, DNA replication inhibitor


102.
1111
CHEK1
CHK1 checkpoint homolog (S. pombe)


103.
7443
VRK1
vaccinia related kinase 1


104.
10376
K-ALPHA-1
tubulin, alpha, ubiquitous


105.
3014
H2AFX
H2A histone family, member X


106.
9055
PRC1
protein regulator of cytokinesis 1


107.
2237
FEN1
flap structure-specific endonuclease 1


108.
81563
C1orf21
chromosome 1 open reading frame 21


109.
51192
CKLF
chemokine-like factor


110.
1062
CENPE
centromere protein E, 312 kDa


111.
11339
OIP5
Opa interacting protein 5


112.
10615
SPAG5
sperm associated antigen 5


113.
55646
LYAR
hypothetical protein FLJ20425


114.
55706
TMEM48
transmembrane protein 48


115.
1058
CENPA
centromere protein A, 17 kDa


116.
3070
HELLS
helicase, lymphoid-specific


117.
4173
MCM4
MCM4 minichromosome maintenance deficient 4





(S. cerevisiae)


118.
23421
ITGB3BP
integrin beta 3 binding protein (beta3-endonexin)


119.
9530
BAG4
BCL2-associated athanogene 4


120.
801
CALM1
calmodulin 1 (phosphorylase kinase, delta)


121.
54069
C21orf45
chromosome 21 open reading frame 45


122.
283991
MGC29814
hypothetical protein MGC29814


123.
63979
FIGNL1
fidgetin-like 1


124.
64105
FKSG14
leucine zipper protein FKSG14


125.
4172
MCM3
MCM3 minichromosome maintenance deficient 3





(S. cerevisiae)


126.
24137
KIF4A
kinesin family member 4A


127.
7398
USP1
ubiquitin specific protease 1


128.
84930
MASTL
microtubule associated serine/threonine kinase-like


129.
51512
GTSE1
G-2 and S-phase expressed 1


130.
4678
NASP
nuclear autoantigenic sperm protein (histone-





binding)


131.
699
BUB1
BUB1 budding uninhibited by benzimidazoles 1





homolog (yeast)


132.
1719
DHFR
dihydrofolate reductase


133.
494143
LOC494143
similar to RIKEN cDNA 2510006C20 gene


134.
55055
FLJ10036
Zwilch


135.
672
BRCA1
breast cancer 1, early onset


136.
64946
CENPH
centromere protein H


137.
83461
CDCA3
cell division cycle associated 3


138.
7465
WEE1
WEE1 homolog (S. pombe)


139.
5984
RFC4
replication factor C (activator 1) 4, 37 kDa


140.
64581
CLEC7A
C-type lectin domain family 7, member A


141.
1230
CCR1
chemokine (C-C motif) receptor 1


142.
4175
MCM6
MCM6 minichromosome maintenance deficient 6





(MIS5 homolog, S. pombe) (S. cerevisiae)


143.
55502
HES6
hairy and enhancer of split 6 (Drosophila)


144.
64151
HCAP-G
chromosome condensation protein G


145.
11151
CORO1A
coronin, actin binding protein, 1A


146.
203068
TUBB
tubulin, beta polypeptide


147.
10926
ASK
activator of S phase kinase


148.
11073
TOPBP1
topoisomerase (DNA) II binding protein 1


149.
90417
C15orf23
chromosome 15 open reading frame 23


150.
9493
KIF23
kinesin family member 23


151.
387882
LOC387882
hypothetical protein


152.
23234
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9


153.
2146
EZH2
enhancer of zeste homolog 2 (Drosophila)


154.
6627
SNRPA1
small nuclear ribonucleoprotein polypeptide A′


155.
5982
RFC2
replication factor C (activator 1) 2, 40 kDa


156.
51155
HN1
hematological and neurological expressed 1


157.
10635
RAD51AP1
RAD51 associated protein 1


158.
91057
NY-REN-41
NY-REN-41 antigen


159.
11168
PSIP1
PC4 and SFRS1 interacting protein 1


160.
10403
KNTC2
kinetochore associated 2


161.
4751
NEK2
NIMA (never in mitosis gene a)-related kinase 2


162.
29028
ATAD2
ATPase family, AAA domain containing 2


163.
26271
FBXO5
F-box protein 5


164.
54892
LUZP5
leucine zipper protein 5


165.
79723
SUV39H2
suppressor of variegation 3-9 homolog 2





(Drosophila)


166.
23590
TPRT
trans-prenyltransferase


167.
2288
FKBP4
FK506 binding protein 4, 59 kDa


168.
23165
NUP205
nucleoporin 205 kDa


169.
6240
RRM1
ribonucleotide reductase M1 polypeptide


170.
81539
SLC38A1
solute carrier family 38, member 1


171.
1894
ECT2
epithelial cell transforming sequence 2 oncogene


172.
55872
PBK
PDZ binding kinase


173.
55635
DEPDC1
DEP domain containing 1


174.
11013
TMSL8
thymosin-like 8


175.
259266
ASPM
asp (abnormal spindle)-like, microcephaly





associated (Drosophila)


176.
10950
BTG3
BTG family, member 3


177.
56992
KIF15
kinesin family member 15


178.
29980
DONSON
downstream neighbor of SON


179.
5757
PTMA
prothymosin, alpha (gene sequence 28)


180.
5932
RBBP8
retinoblastoma binding protein 8


181.
7903
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-





sialyltransferase 4


182.
348235
FAM33A
family with sequence similarity 33, member A


183.
3182
HNRPAB
heterogeneous nuclear ribonucleoprotein A/B


184.
3161
HMMR
hyaluronan-mediated motility receptor (RHAMM)


185.
5985
RFC5
replication factor C (activator 1) 5, 36.5 kDa


186.
864
RUNX3
runt-related transcription factor 3


187.
3930
LBR
lamin B receptor


188.
1434
CSE1L
CSE1 chromosome segregation 1-like (yeast)


189.
81610
C20orf129
chromosome 20 open reading frame 129


190.
3146
HMGB1
high-mobility group box 1


191.
55636
CHD7
chromodomain helicase DNA binding protein 7


192.
54443
ANLN
anillin, actin binding protein (scraps homolog,





Drosophila)


193.
5698
PSMB9
proteasome (prosome, macropain) subunit, beta





type, 9 (large multifunctional protease 2)


194.
7277
TUBA1
tubulin, alpha 1 (testis specific)


195.
64282
PAPD5
PAP associated domain containing 5


196.
201725
LOC201725
hypothetical protein LOC201725


197.
7171
TPM4
tropomyosin 4


198.
3838
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha





1)


199.
116832
RPL39L
ribosomal protein L39-like


200.
4602
MYB
v-myb myeloblastosis viral oncogene homolog





(avian)


201.
54962
FLJ20516
timeless-interacting protein


202.
10541
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32





family, member B


203.
9787
DLG7
discs, large homolog 7 (Drosophila)


204.
147138
EVER2
epidermodysplasia verruciformis 2


205.
157313
CDCA2
cell division cycle associated 2


206.
11340
EXOSC8
exosome component 8


207.
2956
MSH6
mutS homolog 6 (E. coli)


208.
151246
SGOL2
shugoshin-like 2 (S. pombe)


209.
27346
MAC30
hypothetical protein MAC30


210.
5873
RAB27A
RAB27A, member RAS oncogene family


211.
79596
C13orf7
chromosome 13 open reading frame 7


212.
10051
SMC4L1
SMC4 structural maintenance of chromosomes 4-





like 1 (yeast)


213.
3336
HSPE1
heat shock 10 kDa protein 1 (chaperonin 10)


214.
6432
SFRS7
splicing factor, arginine/serine-rich 7, 35 kDa


215.
8819
SAP30
sin3-associated polypeptide, 30 kDa


216.
54801
FAM29A
family with sequence similarity 29, member A


217.
1123
CHN1
chimerin (chimaerin) 1


218.
694
BTG1
B-cell translocation gene 1, anti-proliferative


219.
153222
LOC153222
adult retina protein


220.
3669
ISG20
interferon stimulated exonuclease gene 20 kDa


221.
151556
GPR155
G protein-coupled receptor 155


222.
6591
SNAI2
snail homolog 2 (Drosophila)


223.
5920
RARRES3
retinoic acid receptor responder (tazarotene





induced) 3


224.
400172
LOC400172
similar to KIAA1641 protein; melanoma-associated





antigen; CLL-associated antigen KW-1


225.
55281
FLJ11000
hypothetical protein FLJ11000


226.
9783
RIMS3
regulating synaptic membrane exocytosis 3


227.
6480
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1


228.
390
RND3
Rho family GTPase 3


229.
10765
JARID1B
Jumonji, AT rich interactive domain 1B (RBP2-like)


230.
154091
SLC2A12
solute carrier family 2 (facilitated glucose





transporter), member 12


231.
54981
C9orf95
chromosome 9 open reading frame 95


232.
1663
DDX11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11





(CHL1-like helicase homolog, S. cerevisiae)


233.
54800
DRE1
DRE1 protein


234.
57515
TDE2
tumor differentially expressed 2


235.
83719
YPEL3
yippee-like 3 (Drosophila)


236.
5269
SERPINB6
serine (or cysteine) proteinase inhibitor, clade B





(ovalbumin), member 6


237.
30061
SLC40A1
solute carrier family 40 (iron-regulated transporter),





member 1


238.
5660
PSAP
prosaposin (variant Gaucher disease and variant





metachromatic leukodystrophy)


239.
51646
YPEL5
yippee-like 5 (Drosophila)


240.
145788
FLJ27352
hypothetical LOC145788


241.
81030
ZBP1
Z-DNA binding protein 1


242.
57035
C1orf63
chromosome 1 open reading frame 63


243.
9863
MAGI2
membrane associated guanylate kinase, WW and





PDZ domain containing 2


244.
9855
FARP2
FERM, RhoGEF and pleckstrin domain protein 2


245.
57612
KIAA1466
KIAA1466 gene


246.
56243
KIAA1217
KIAA1217


247.
8365
HIST1H4H
histone 1, H4h


248.
440081
DDX12
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12





(CHL1-like helicase homolog, S. cerevisiae)


249.
83937
RASSF4
Ras association (RalGDS/AF-6) domain family 4


250.
56204
FLJ10980
hypothetical protein FLJ10980


251.
22932
POMZP3
POM (POM121 homolog, rat) and ZP3 fusion


252.
10628
TXNIP
thioredoxin interacting protein


253.
6720
SREBF1
sterol regulatory element binding transcription factor 1


254.
1508
CTSB
cathepsin B


255.
84513
HTPAP
HTPAP protein


256.
85352
KIAA1644
KIAA1644 protein


257.
9388
LIPG
lipase, endothelial


258.
5163
PDK1
pyruvate dehydrogenase kinase, isoenzyme 1


259.
23446
CDW92
CDW92 antigen


260.
10156
RASA4
RAS p21 protein activator 4


261.
23766
GABARAPL3
GABA(A) receptors associated protein like 3


262.
56904
SH3GLB2
SH3-domain GRB2-like endophilin B2


263.
6609
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal





(acid sphingomyelinase)


264.
23259
DDHD2
DDHD domain containing 2


265.
23092
ARHGAP26
Rho GTPase activating protein 26


266.
27250
PDCD4
programmed cell death 4 (neoplastic transformation





inhibitor)


267.
3983
ABLIM1
actin binding LIM protein 1


268.
23461
ABCA5
ATP-binding cassette, sub-family A (ABC1),





member 5


269.
4094
MAF
v-maf musculoaponeurotic fibrosarcoma oncogene





homolog (avian)


270.
23646
PLD3
phospholipase D family, member 3


271.
51566
ARMCX3
armadillo repeat containing, X-linked 3


272.
58476
TP53INP2
tumor protein p53 inducible nuclear protein 2


273.
29994
BAZ2B
bromodomain adjacent to zinc finger domain, 2B


274.
283131
TncRNA
trophoblast-derived noncoding RNA


275.
4189
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9


276.
9123
SLC16A3
solute carrier family 16 (monocarboxylic acid





transporters), member 3


277.
8473
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase





(UDP-N-acetylglucosamine:polypeptide-N-





acetylglucosaminyl transferase)


278.
65018
PINK1
PTEN induced putative kinase 1


279.
23512
SUZ12
suppressor of zeste 12 homolog (Drosophila)


280.
81611
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32





family, member E


281.
5880
RAC2
ras-related C3 botulinum toxin substrate 2 (rho





family, small GTP binding protein Rac2)


282.
6941
TCF19
transcription factor 19 (SC1)


283.
8836
GGH
gamma-glutamyl hydrolase (conjugase,





folylpolygammaglutamyl hydrolase)


284.
9830
TRIM14
tripartite motif-containing 14


285.
55026
FLJ20716
hypothetical protein FLJ20716


286.
84057
GAJ
GAJ protein


287.
6510
SLC1A5
solute carrier family 1 (neutral amino acid





transporter), member 5


288.
84969
C20orf100
chromosome 20 open reading frame 100


289.
81620
CDT1
DNA replication factor


290.
113115
FAM54A
family with sequence similarity 54, member A


291.
3159
HMGA1
high mobility group AT-hook 1


292.
3251
HPRT1
hypoxanthine phosphoribosyltransferase 1 (Lesch-





Nyhan syndrome)


293.
5214
PFKP
phosphofructokinase, platelet


294.
2171
FABP5
fatty acid binding protein 5 (psoriasis-associated)


295.
57082
CASC5
cancer susceptibility candidate 5


296.
5889
RAD51C
RAD51 homolog C (S. cerevisiae)


297.
6628
SNRPB
small nuclear ribonucleoprotein polypeptides B and





B1


298.
134111
FLJ25076
similar to CG4502-PA


299.
397
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta


300.
129401
NUP35
nucleoporin 35 kDa


301.
6632
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide





16 kDa


302.
10212
DDX39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39


303.
6472
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)


304.
55536
CDCA7L
cell division cycle associated 7-like


305.
64116
SLC39A8
solute carrier family 39 (zinc transporter), member 8


306.
79902
PCNT1
pericentrin 1


307.
7371
UCK2
uridine-cytidine kinase 2


308.
11332
BACH
brain acyl-CoA hydrolase


309.
3320
HSPCA
heat shock 90 kDa protein 1, alpha


310.
1019
CDK4
cyclin-dependent kinase 4


311.
10383
TUBB2
tubulin, beta, 2


312.
8243
SMC1L1
SMC1 structural maintenance of chromosomes 1-





like 1 (yeast)


313.
1786
DNMT1
DNA (cytosine-5-)-methyltransferase 1


314.
22929
SEPHS1
selenophosphate synthetase 1


315.
10492
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting





protein


316.
26051
PPP1R16B
protein phosphatase 1, regulatory (inhibitor) subunit





16B


317.
5168
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase





2 (autotaxin)


318.
51144
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12


319.
9446
GSTO1
glutathione S-transferase omega 1


320.
51002
CGI-121
CGI-121 protein


321.
51377
UCHL5
ubiquitin carboxyl-terminal hydrolase L5


322.
10606
PAICS
phosphoribosylaminoimidazole carboxylase,





phosphoribosylaminoimidazole succinocarboxamide





synthetase


323.
6929
TCF3
transcription factor 3 (E2A immunoglobulin





enhancer binding factors E12/E47)


324.
262
AMD1
adenosylmethionine decarboxylase 1


325.
3676
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of





VLA-4 receptor)


326.
39
ACAT2
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl





Coenzyme A thiolase)


327.
23526
HA-1
minor histocompatibility antigen HA-1


328.
79023
NUP37
nucleoporin 37 kDa


329.
6119
RPA3
replication protein A3, 14 kDa


330.
6657
SOX2
SRY (sex determining region Y)-box 2


331.
27101
CACYBP
calcyclin binding protein


332.
55752
11-Sep
septin 11


333.
79017
C7orf24
chromosome 7 open reading frame 24


334.
10808
HSPH1
heat shock 105 kDa/110 kDa protein 1


335.
11051
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type





motif 21


336.
5631
PRPS1
phosphoribosyl pyrophosphate synthetase 1


337.
55352
HSA272196
hypothetical protein, clone 2746033


338.
8727
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1


339.
26586
CKAP2
cytoskeleton associated protein 2


340.
2271
FH
fumarate hydratase


341.
23246
BOP1
block of proliferation 1


342.
5696
PSMB8
proteasome (prosome, macropain) subunit, beta





type, 8 (large multifunctional protease 7)


343.
25804
LSM4
LSM4 homolog, U6 small nuclear RNA associated





(S. cerevisiae)


344.
5557
PRIM1
primase, polypeptide 1, 49 kDa


345.
4436
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1





(E. coli)


346.
5885
RAD21
RAD21 homolog (S. pombe)


347.
22948
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)


348.
9126
CSPG6
chondroitin sulfate proteoglycan 6 (bamacan)


349.
9184
BUB3
BUB3 budding uninhibited by benzimidazoles 3





homolog (yeast)


350.
4869
NPM1
nucleophosmin (nucleolar phosphoprotein B23,





numatrin)


351.
3150
HMGN1
high-mobility group nucleosome binding domain 1


352.
10409
BASP1
brain abundant, membrane attached signal protein 1


353.
4200
ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial


354.
169270
ZNF596
zinc finger protein 596


355.
3939
LDHA
lactate dehydrogenase A


356.
961
CD47
CD47 antigen (Rh-related antigen, integrin-





associated signal transducer)


357.
9368
SLC9A3R1
solute carrier family 9 (sodium/hydrogen





exchanger), isoform 3 regulator 1


358.
7086
TKT
transketolase (Wernicke-Korsakoff syndrome)


359.
10801
9-Sep
septin 9


360.
10785
WDR4
WD repeat domain 4


361.
3033
HADHSC
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short





chain


362.
8833
GMPS
guanine monphosphate synthetase


363.
27316
RBMX
RNA binding motif protein, X-linked


364.
5725
PTBP1
polypyrimidine tract binding protein 1


365.
10128
LRPPRC
leucine-rich PPR-motif containing


366.
84250
ANKRD32
ankyrin repeat domain 32


367.
5358
PLS3
plastin 3 (T isoform)


368.
4673
NAP1L1
nucleosome assembly protein 1-like 1


369.
3149
HMGB3
high-mobility group box 3


370.
2289
FKBP5
FK506 binding protein 5


371.
22856
CHSY1
carbohydrate (chondroitin) synthase 1


372.
6566
SLC16A1
solute carrier family 16 (monocarboxylic acid





transporters), member 1


373.
54149
C21orf91
chromosome 21 open reading frame 91


374.
54517
FLJ20485
hypothetical protein FLJ20485


375.
8514
KCNAB2
potassium voltage-gated channel, shaker-related





subfamily, beta member 2


376.
119
ADD2
adducin 2 (beta)


377.
1407
CRY1
cryptochrome 1 (photolyase-like)


378.
204
AK2
adenylate kinase 2


379.
467
ATF3
activating transcription factor 3


380.
64778
FNDC3B
fibronectin type III domain containing 3B


381.
347733
RP11-506K6.1
tubulin, beta polypeptide paralog


382.
9604
RNF14
ring finger protein 14


383.
7832
BTG2
BTG family, member 2


384.
120196
MGC34830
hypothetical protein MGC34830


385.
9910
RABGAP1L
RAB GTPase activating protein 1-like


386.
55876
GSDML
gasdermin-like


387.
1524
CX3CR1
chemokine (C—X3—C motif) receptor 1


388.
23015
GM88
88-kDa golgi protein


389.
1604
DAF
decay accelerating factor for complement (CD55,





Cromer blood group system)


390.
114793
FMNL2
formin-like 2


391.
50640
IPLA2(GAMMA)
intracellular membrane-associated calcium-





independent phospholipase A2 gamma


392.
222166
EIIs1
hypothetical protein EIIs1


393.
10140
TOB1
transducer of ERBB2, 1


394.
1647
GADD45A
growth arrest and DNA-damage-inducible, alpha


395.
25840
DKFZP586A0522
DKFZP586A0522 protein


396.
150759
LOC150759
hypothetical protein LOC150759


397.
6448
SGSH
N-sulfoglucosamine sulfohydrolase (sulfamidase)


398.
85236
HIST1H2BK
histone 1, H2bk


399.
9728
KIAA0256
KIAA0256 gene product


400.
3727
JUND
jun D proto-oncogene


401.
54741
LEPROT
leptin receptor overlapping transcript


402.
5973
RENBP
renin binding protein


403.
84897
TBRG1
transforming growth factor beta regulator 1


404.
92370
ACPL2
acid phosphatase-like 2


405.
23208
SYT11
synaptotagmin XI


406.
375593
TRIM50B
tripartite motif-containing 50B


407.
94241
TP53INP1
tumor protein p53 inducible nuclear protein 1


408.
1612
DAPK1
death-associated protein kinase 1


409.
144203
OVOS2
ovostatin 2


410.
3915
LAMC1
laminin, gamma 1 (formerly LAMB2)


411.
115701
ALPK2
alpha-kinase 2


412.
1203
CLN5
ceroid-lipofuscinosis, neuronal 5


413.
51363
GALNAC4S-6ST
B cell RAG associated protein


414.
387263
C6orf120
chromosome 6 open reading frame 120


415.
2824
GPM6B
glycoprotein M6B


416.
8516
ITGA8
integrin, alpha 8


417.
57730
KIAA1641
KIAA1641


418.
10370
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-





rich carboxy-terminal domain, 2


419.
1611
DAP
death-associated protein


420.
388677
NOTCH2NL
Notch homolog 2 (Drosophila) N-terminal like


421.
132720
FLJ39370
hypothetical protein FLJ39370


422.
29005
PRO1073
PRO1073 protein


423.
1030
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits





CDK4)


424.
23336
DMN
desmuslin


425.
23643
LY96
lymphocyte antigen 96


426.
4779
NFE2L1
nuclear factor (erythroid-derived 2)-like 1


427.
7286
TUFT1
tuftelin 1


428.
1200
TPP1
tripeptidyl peptidase I


429.
27344
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor


430.
9473
C1orf38
chromosome 1 open reading frame 38


431.
401152
LOC401152
HCV F-transactivated protein 1


432.
5360
PLTP
phospholipid transfer protein


433.
7846
TUBA3
tubulin, alpha 3


434.
9240
PNMA1
paraneoplastic antigen MA1


435.
81631
MAP1LC3B
microtubule-associated protein 1 light chain 3 beta


436.
112770
C1orf85
chromosome 1 open reading frame 85


437.
3998
LMAN1
lectin, mannose-binding, 1


438.
8987
GENX-3414
genethonin 1


439.
84218
TBC1D3
TBC1 domain family, member 3


440.
51237
PACAP
proapoptotic caspase adaptor protein


441.
55818
JMJD1A
jumonji domain containing 1A


442.
11057
ABHD2
abhydrolase domain containing 2


443.
2180
ACSL1
acyl-CoA synthetase long-chain family member 1


444.
10525
HYOU1
hypoxia up-regulated 1


445.
114915
TIGA1
TIGA1


446.
55251
C20orf36
chromosome 20 open reading frame 36


447.
598
BCL2L1
BCL2-like 1


448.
51111
SUV420H1
suppressor of variegation 4-20 homolog 1





(Drosophila)


449.
64065
PERP
PERP, TP53 apoptosis effector


450.
2037
EPB41L2
erythrocyte membrane protein band 4.1-like 2


451.
89796
NAV1
neuron navigator 1


452.
9341
VAMP3
vesicle-associated membrane protein 3 (cellubrevin)


453.
1465
CSRP1
cysteine and glycine-rich protein 1


454.
60492
MDS025
hypothetical protein MDS025


455.
339448
LOC339448
hypothetical protein LOC339448


456.
6513
SLC2A1
solute carrier family 2 (facilitated glucose





transporter), member 1


457.
3995
FADS3
fatty acid desaturase 3


458.
155038
GIMAP8
GTPase, IMAP family member 8


459.
90634
CG018
hypothetical gene CG018


460.
55573
H41
hypothetical protein H41


461.
7514
XPO1
exportin 1 (CRM1 homolog, yeast)


462.
196527
TMEM16F
transmembrane protein 16F


463.
5471
PPAT
phosphoribosyl pyrophosphate amidotransferase


464.
22823
MTF2
metal response element binding transcription factor 2


465.
10856
RUVBL2
RuvB-like 2 (E. coli)


466.
6713
SQLE
squalene epoxidase


467.
8407
TAGLN2
transgelin 2


468.
26135
PAI-RBP1
PAI-1 mRNA binding protein


469.
84247
LDOC1L
leucine zipper, down-regulated in cancer 1-like


470.
9201
DCAMKL1
doublecortin and CaM kinase-like 1


471.
388403
YPEL2
yippee-like 2 (Drosophila)


472.
255631
COL24A1
collagen, type XXIV, alpha 1


473.
8440
NCK2
NCK adaptor protein 2


474.
81790
RNF170
ring finger protein 170


475.
9706
ULK2
unc-51-like kinase 2 (C. elegans)


476.
4092
SMAD7
SMAD, mothers against DPP homolog 7





(Drosophila)


477.
51184
MGC14560
protein x 0004


478.
7334
UBE2N
ubiquitin-conjugating enzyme E2N (UBC13





homolog, yeast)


479.
84955
NUDCD1
NudC domain containing 1


480.
5684
PSMA3
proteasome (prosome, macropain) subunit, alpha





type, 3


481.
51465
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6





homolog, yeast)


482.
286319
TUSC1
tumor suppressor candidate 1


483.
26207
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1


484.
51303
FKBP11
FK506 binding protein 11, 19 kDa


485.
9139
CBFA2T2
core-binding factor, runt domain, alpha subunit 2;





translocated to, 2


486.
57714
KIAA1618
KIAA1618


487.
94240
EPSTI1
epithelial stromal interaction 1 (breast)


488.
659
BMPR2
bone morphogenetic protein receptor, type II





(serine/threonine kinase)


489.
934
CD24
CD24 antigen (small cell lung carcinoma cluster 4





antigen)


490.
9532
BAG2
BCL2-associated anthanogene 2


491.
23331
KIAA1043
KIAA1043 protein


492.
10675
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)


493.
1102
RCBTB2
regulator of chromosome condensation (RCC1) and





BTB (POZ) domain containing protein 2


494.
2119
ETV5
ets variant gene 5 (ets-related molecule)


495.
255488
IBRDC2
IBR domain containing 2


496.
55076
TMEM45A
transmembrane protein 45A


497.
8364
HIST1H4C
histone 1, H4c


498.
3725
JUN
v-jun sarcoma virus 17 oncogene homolog (avian)


499.
384
ARG2
arginase, type II


500.
10129
13CDNA73
hypothetical protein CG003


501.
1960
EGR3
early growth response 3


502.
27122
DKK3
dickkopf homolog 3 (Xenopus laevis)


503.
11178
LZTS1
leucine zipper, putative tumor suppressor 1


504.
143888
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2


505.
1601
DAB2
disabled homolog 2, mitogen-responsive





phosphoprotein (Drosophila)


506.
6542
SLC7A2
solute carrier family 7 (cationic amino acid





transporter, y+ system), member 2


507.
477
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 (+)





polypeptide


508.
90161
HS6ST2
heparan sulfate 6-O-sulfotransferase 2


509.
81031
SLC2A10
solute carrier family 2 (facilitated glucose





transporter), member 10


510.
56675
NRIP3
nuclear receptor interacting protein 3


511.
1958
EGR1
early growth response 1


512.
3714
JAG2
jagged 2


513.
3897
L1CAM
L1 cell adhesion molecule


514.
1488
CTBP2
C-terminal binding protein 2


515.
145173
B3GTL
beta 3-glycosyltransferase-like


516.
112399
EGLN3
egl nine homolog 3 (C. elegans)


517.
22871
NLGN1
neuroligin 1


518.
8804
CREG1
cellular repressor of E1A-stimulated genes 1


519.
401081
FLJ22763
hypothetical gene supported by AK026416


520.
25924
MYRIP
myosin VIIA and Rab interacting protein


521.
91694
FLJ23749
hypothetical protein FLJ23749


522.
56155
TEX14
testis expressed sequence 14


523.
1349
COX7B
cytochrome c oxidase subunit VIIb


524.
3695
ITGB7
integrin, beta 7


525.
1164
CKS2
CDC28 protein kinase regulatory subunit 2


526.
56919
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33


527.
3276
HRMT1L2
HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)


528.
116151
C20orf108
chromosome 20 open reading frame 108


529.
25758
G2
G2 protein


530.
25861
DFNB31
deafness, autosomal recessive 31


531.
9666
DZIP3
zinc finger DAZ interacting protein 3


532.
1486
CTBS
chitobiase, di-N-acetyl-


533.
3123
HLA-DRB1
major histocompatibility complex, class II, DR beta 1


534.
317649
EIF4E3
eukaryotic translation initiation factor 4E member


535.
50854
C6orf48
chromosome 6 open reading frame 48


536.
401024
FLJ44048
FLJ44048 protein


537.
114327
EFHC1
EF-hand domain (C-terminal) containing 1


538.
8334
HIST1H2AC
histone 1, H2ac


539.
284214
LOC284214
hypothetical protein LOC284214


540.
10379
ISGF3G
interferon-stimulated transcription factor 3, gamma





48 kDa


541.
113177
C19orf36
chromosome 19 open reading frame 36


542.
56951
C5orf15
chromosome 5 open reading frame 15


543.
285362
SUMF1
sulfatase modifying factor 1


544.
3490
IGFBP7
insulin-like growth factor binding protein 7


545.
1186
CLCN7
chloride channel 7


546.
582
BBS1
Bardet-Biedl syndrome 1


547.
339456
LOC339456
hypothetical protein LOC339456


548.
26115
DKFZP564D166
putative ankyrin-repeat containing protein


549.
9895
KIAA0329
KIAA0329


550.
1040
CDS1
CDP-diacylglycerol synthase (phosphatidate





cytidylyltransferase) 1


551.
51496
HSPC129
hypothetical protein HSPC129


552.
1039
CDR2
cerebellar degeneration-related protein 2, 62 kDa


553.
130589
GALM
galactose mutarotase (aldose 1-epimerase)


554.
3937
LCP2
lymphocyte cytosolic protein 2 (SH2 domain





containing leukocyte protein of 76 kDa)


555.
3535
IGL@
immunoglobulin lambda locus


556.
1396
CRIP1
cysteine-rich protein 1 (intestinal)


557.
4291
MLF1
myeloid leukemia factor 1


558.
9972
NUP153
nucleoporin 153 kDa


559.
10459
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)


560.
483
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide


561.
8165
AKAP1
A kinase (PRKA) anchor protein 1


562.
29097
CNIH4
cornichon homolog 4 (Drosophila)


563.
7037
TFRC
transferrin receptor (p90, CD71)


564.
509
ATP5C1
ATP synthase, H+ transporting, mitochondrial F1





complex, gamma polypeptide 1


565.
10682
EBP
emopamil binding protein (sterol isomerase)


566.
56172
ANKH
ankylosis, progressive homolog (mouse)


567.
100
ADA
adenosine deaminase


568.
2821
GPI
glucose phosphate isomerase


569.
54927
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3


570.
58478
MASA
E-1 enzyme


571.
292
SLC25A5
solute carrier family 25 (mitochondrial carrier;





adenine nucleotide translocator), member 5


572.
51096
WDR50
WD repeat domain 50


573.
79053
ALG8
asparagine-linked glycosylation 8 homolog (yeast,





alpha-1,3-glucosyltransferase)


574.
84300
C6orf125
chromosome 6 open reading frame 125


575.
253461
ZBTB38
zinc finger and BTB domain containing 38


576.
29080
HSPC128
HSPC128 protein


577.
1622
DBI
diazepam binding inhibitor (GABA receptor





modulator, acyl-Coenzyme A binding protein)


578.
2029
ENSA
endosulfine alpha


579.
6404
SELPLG
selectin P ligand


580.
7295
TXN
thioredoxin


581.
10539
TXNL2
thioredoxin-like 2


582.
3422
IDI1
isopentenyl-diphosphate delta isomerase


583.
1964
EIF1AX
eukaryotic translation initiation factor 1A, X-linked


584.
11191
PTENP1
phosphatase and tensin homolog (mutated in





multiple advanced cancers 1), pseudogene 1


585.
80853
KIAA1718
KIAA1718 protein


586.
7096
TLR1
toll-like receptor 1


587.
440270
LOC440270
golgin-67


588.
8879
SGPL1
sphingosine-1-phosphate lyase 1


589.
493812
HCG11
HLA complex group 11


590.
257103
C21orf86
chromosome 21 open reading frame 86


591.
55615
PRR5
proline rich protein 5


592.
7905
C5orf18
chromosome 5 open reading frame 18


593.
64062
C13orf10
chromosome 13 open reading frame 10


594.
10133
OPTN
optineurin


595.
10116
FEM1B
fem-1 homolog b (C. elegans)


596.
79027
ZNF655
zinc finger protein 655


597.
79717
FLJ11838
hypothetical protein FLJ11838


598.
10397
NDRG1
N-myc downstream regulated gene 1


599.
3338
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4




















TABLE V







ENTREZ





GENE ID
GENE SYMBOL
GENE DESCRIPTION



















1.
934
CD24
CD24 antigen (small cell lung carcinoma cluster 4





antigen)


2.
9532
BAG2
BCL2-associated athanogene 2


3.
23331
KIAA1043
KIAA1043 protein


4.
10675
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)


5.
1102
RCBTB2
regulator of chromosome condensation (RCC1) and





BTB (POZ) domain containing protein 2


6.
2119
ETV5
ets variant gene 5 (ets-related molecule)


7.
255488
IBRDC2
IBR domain containing 2


8.
55076
TMEM45A
transmembrane protein 45A


9.
8364
HIST1H4C
histone 1, H4c


10.
3725
JUN
v-jun sarcoma virus 17 oncogene homolog (avian)


11.
384
ARG2
arginase, type II


12.
10129
13CDNA73
hypothetical protein CG003


13.
401081
FLJ22763
hypothetical gene supported by AK026416


14.
25924
MYRIP
myosin VIIA and Rab interacting protein


15.
91694
FLJ23749
hypothetical protein FLJ23749


16.
56155
TEX14
testis expressed sequence 14


17.
1349
COX7B
cytochrome c oxidase subunit VIIb


18.
1164
CKS2
CDC28 protein kinase regulatory subunit 2


19.
56919
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33


20.
3276
HRMT1L2
HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)


21.
3695
ITGB7
integrin, beta 7


22.
51496
HSPC129
hypothetical protein HSPC129


23.
1039
CDR2
cerebellar degeneration-related protein 2, 62 kDa


24.
130589
GALM
galactose mutarotase (aldose 1-epimerase)


25.
3937
LCP2
lymphocyte cytosolic protein 2 (SH2 domain





containing leukocyte protein of 76 kDa)


26.
3535
IGL@
immunoglobulin lambda locus


27.
1396
CRIP1
cysteine-rich protein 1 (intestinal)


28.
4291
MLF1
myeloid leukemia factor 1


29.
9972
NUP153
nucleoporin 153 kDa


30.
10459
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)


31.
483
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide


32.
8165
AKAP1
A kinase (PRKA) anchor protein 1


33.
29097
CNIH4
cornichon homolog 4 (Drosophila)


34.
7037
TFRC
transferrin receptor (p90, CD71)


35.
509
ATP5C1
ATP synthase, H+ transporting, mitochondrial F1





complex, gamma polypeptide 1


36.
10682
EBP
emopamil binding protein (sterol isomerase)


37.
56172
ANKH
ankylosis, progressive homolog (mouse)


38.
100
ADA
adenosine deaminase


39.
2821
GPI
glucose phosphate isomerase


40.
54927
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3


41.
58478
MASA
E-1 enzyme


42.
292
SLC25A5
solute carrier family 25 (mitochondrial carrier;





adenine nucleotide translocator), member 5


43.
51096
WDR50
WD repeat domain 50


44.
79053
ALG8
asparagine-linked glycosylation 8 homolog (yeast,





alpha-1,3-glucosyltransferase)


45.
84300
C6orf125
chromosome 6 open reading frame 125


46.
253461
ZBTB38
zinc finger and BTB domain containing 38


47.
29080
HSPC128
HSPC128 protein


48.
1622
DBI
diazepam binding inhibitor (GABA receptor





modulator, acyl-Coenzyme A binding protein)


49.
2029
ENSA
endosulfine alpha


50.
6404
SELPLG
selectin P ligand


51.
7295
TXN
thioredoxin


52.
10539
TXNL2
thioredoxin-like 2


53.
3422
IDI1
isopentenyl-diphosphate delta isomerase


54.
1964
EIF1AX
eukaryotic translation initiation factor 1A, X-linked


55.
11191
PTENP1
phosphatase and tensin homolog (mutated in





multiple advanced cancers 1), pseudogene 1


56.
1960
EGR3
early growth response 3


57.
3338
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4


58.
10397
NDRG1
N-myc downstream regulated gene 1


59.
79717
FLJ11838
hypothetical protein FLJ11838


60.
79027
ZNF655
zinc finger protein 655


61.
10116
FEM1B
fem-1 homolog b (C. elegans)


62.
10133
OPTN
optineurin


63.
64062
C13orf10
chromosome 13 open reading frame 10


64.
7905
C5orf18
chromosome 5 open reading frame 18


65.
55615
PRR5
proline rich protein 5


66.
257103
C21orf86
chromosome 21 open reading frame 86


67.
493812
HCG11
HLA complex group 11


68.
8879
SGPL1
sphingosine-1-phosphate lyase 1


69.
440270
LOC440270
golgin-67


70.
7096
TLR1
toll-like receptor 1


71.
80853
KIAA1718
KIAA1718 protein


72.
1040
CDS1
CDP-diacylglycerol synthase (phosphatidate





cytidylyltransferase) 1


73.
9895
KIAA0329
KIAA0329


74.
26115
DKFZP564D166
putative ankyrin-repeat containing protein


75.
339456
LOC339456
hypothetical protein LOC339456


76.
582
BBS1
Bardet-Biedl syndrome 1


77.
1186
CLCN7
chloride channel 7


78.
3490
IGFBP7
insulin-like growth factor binding protein 7


79.
285362
SUMF1
sulfatase modifying factor 1


80.
56951
C5orf15
chromosome 5 open reading frame 15


81.
113177
C19orf36
chromosome 19 open reading frame 36


82.
10379
ISGF3G
interferon-stimulated transcription factor 3, gamma





48 kDa


83.
284214
LOC284214
hypothetical protein LOC284214


84.
8334
HIST1H2AC
histone 1, H2ac


85.
114327
EFHC1
EF-hand domain (C-terminal) containing 1


86.
401024
FLJ44048
FLJ44048 protein


87.
50854
C6orf48
chromosome 6 open reading frame 48


88.
317649
EIF4E3
eukaryotic translation initiation factor 4E member 3


89.
3123
HLA-DRB1
major histocompatibility complex, class II, DR beta 1


90.
1486
CTBS
chitobiase, di-N-acetyl-


91.
9666
DZIP3
zinc finger DAZ interacting protein 3


92.
25861
DFNB31
deafness, autosomal recessive 31


93.
25758
G2
G2 protein


94.
116151
C20orf108
chromosome 20 open reading frame 108


95.
8804
CREG1
cellular repressor of E1A-stimulated genes 1


96.
22871
NLGN1
neuroligin 1


97.
112399
EGLN3
egl nine homolog 3 (C. elegans)


98.
145173
B3GTL
beta 3-glycosyltransferase-like


99.
1488
CTBP2
C-terminal binding protein 2


100.
3897
L1CAM
L1 cell adhesion molecule


101.
3714
JAG2
jagged 2


102.
1958
EGR1
early growth response 1


103.
56675
NRIP3
nuclear receptor interacting protein 3


104.
81031
SLC2A10
solute carrier family 2 (facilitated glucose





transporter), member 10


105.
90161
HS6ST2
heparan sulfate 6-O-sulfotransferase 2


106.
477
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 (+)





polypeptide


107.
6542
SLC7A2
solute carrier family 7 (cationic amino acid





transporter, y+ system), member 2


108.
1601
DAB2
disabled homolog 2, mitogen-responsive





phosphoprotein (Drosophila)


109.
143888
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2


110.
11178
LZTS1
leucine zipper, putative tumor suppressor 1


111.
27122
DKK3
dickkopf homolog 3 (Xenopus laevis)









The gene expression of the biomarkers of Table I or any of its subsets, Tables II through V, may be up- or down-regulated in response to the inhibition of FGFR3. In some instances, the detection of the presence of gene expression of one of the biomarkers may be sufficient to identify the patient for treatment or provide indication of a favorable response to treatment. In other instances, one may prefer the guidance provided by a higher level of alteration of gene expression or a stronger correlation with a particular inhibitory compound.
Further, in some instances, one may find identifying the most suitable patients for treatment for a particular cell proliferative disorder may best be accomplished by detecting an alteration in level of gene expression of two or more biomarkers or by a specific combination of biomarkers or even direction of alteration of gene expression. For example, a particular two of the biomarkers identified in Table I may be most correlated with a given condition and, thus, guide a certain treatment. Alternatively, a ratio of the relative levels of gene expression of two particular biomarkers may be indicative of the suitability of a given treatment for a patient. It is also contemplated that a particular condition may have a signature such as the up-regulation of one or more particular biomarker or biomarkers and/or the down-regulation of one or more other particular biomarker or biomarkers.
The alteration in the level of gene expression may be compared to a baseline level. A baseline level may be established in several ways. For example, in a method of monitoring response of a patient to treatment, a sample may be obtained from the patient and tested for measurement of gene expression prior to introduction of an FGFR3 inhibitor to the patient. Thus, the profile of gene expression levels, if any, of biomarkers in a treatment-naïve individual may serve as a baseline for that individual and later tests performed on samples obtained once treatment has begun may be compared to the individual's baseline. Alternatively, a baseline may be established through creation of a guide that consolidates information on gene expression levels taken from a pool of healthy or treatment-naïve individuals or even from an appropriate cell culture. Further, information on baseline levels of gene expression of particular biomarkers may be gathered from published sources or a gene database.
In one aspect, a sample is isolated from the patient after receipt of an amount of inhibitor of FGFR3, whether a therapeutically effective amount or a sub-therapeutically effective amount, which may be adequate for some purposes. Cell or tissue samples used for this invention encompass body fluid, solid tissue samples, tissue cultures or cells derived therefrom and the progeny thereof, and sections or smears prepared from any of these sources, or any other samples that may contain genetic information. Measurement of the expression of the biomarkers is described in further detail below.
Inhibitors of FGFR3
Some examples of small molecule inhibitors of FGFR3 include CHIR-258 (Chiron Corporation), SU-5402 (Pfizer, Inc.), and PD-173074 (Pfizer, Inc.).
The chemical structure and chemical name of CHIR-258 are shown below.




4-Amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one is a small molecule inhibitor of VEGF-RTK, PDGF-RTK and other receptor tyrosine kinases such as fibroblast growth factor receptor (FGF-RTK). This compound has been described in a patent and several patent applications, the entire disclosures of which are incorporated herein by reference and for all purposes: U.S. Pat. No. 6,605,617, U.S. Ser. No. 10/644,055, U.S. Provisional Application Nos. 60/405,729, 60/428,210, and 60/484,048.
Related compounds are disclosed in patents and applications incorporated herein by reference, as noted. A plethora of substituted quinolinone compounds including quinolinone benzimidazolyl compounds and 4-amino substituted quinolinone benzimidazolyl compounds such as 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one have recently been disclosed in references such as WO 02/22598, WO 2004/043389, WO 2005/047244, U.S. 2004/0220196, U.S. 2005/0137399, WO 2005/046590, and WO 2005/046589. Such compounds are disclosed as inhibiting VEGF-RTKs. Such compounds are also disclosed in published United States patent applications U.S. 2002/0107392 and U.S. 2003/0028018 and U.S. Pat. Nos. 6,605,617, 6,774,237, 6,762,194, and 6,800,760. Other such compounds are disclosed along with new uses of such compounds in inhibiting serine/threonine kinases and tyrosine kinases are disclosed in WO 2004/018419, and U.S. 2004/0092535, filed on Aug. 19, 2003, and claiming priority to each of the following provisional applications: U.S. Provisional Application No. 60/405,729 filed on Aug. 23, 2002; U.S. Provisional Application No. 60/426,107 filed on Nov. 13, 2002; U.S. Provisional Application No. 60/426,226 filed on Nov. 13, 2002; U.S. Provisional Application No. 60/426,282 filed on Nov. 13, 2002; U.S. Provisional Application No. 60/428,210 filed on Nov. 21, 2002; U.S. Provisional Application No. 60/460,327 filed on Apr. 3, 2003; U.S. Provisional Application No. filed on Apr. 3, 2003; U.S. Provisional Application No. 60/460,493 filed on Apr. 3, 2003; U.S. Provisional Application No. 60/478,916 filed on Jun. 16, 2003; and U.S. Provisional Application No. 60/484,048 filed on Jul. 1, 2003. Additional disclosure related to quinolinone compounds and uses thereof is set forth in U.S. Provisional Application No. 60/680,722, filed May 13, 2005; U.S. Provisional Application No. 60/681,893, filed May 17, 2005; U.S. Provisional Application No. 60/546,395, filed Feb. 20, 2004; U.S. Provisional Application No. 60/547,103, filed Feb. 23, 2004; U.S. Provisional Application No. 60/554,771, filed Mar. 19, 2004; U.S. Provisional Application No. 60/647,568, filed Jan. 27, 2005; U.S. Provisional Application No. 60/669,245, filed Apr. 6, 2005; U.S. Provisional Application No. 60/538,594, filed Jan. 23, 2004; U.S. Provisional Application No. 60/683,999; filed May 23, 3005; U.S. patent application Ser. No. 11/061,386, filed Feb. 18, 2005; U.S. patent application Ser. No. 11/041,191, filed Jan. 21, 2005; and PCT Application No. PCT/US2005/05316, filed Feb. 18, 2005. Heterocyclic compounds related to benzimidazolyl quinolinones have recently been disclosed in WO 02/18383, U.S. 2002/0103230, and U.S. Pat. No. 6,756,383. Each of the references in this paragraph is hereby incorporated by reference in its entirety and for all purposes as if fully set forth herein.
The SU-5402 compound is 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone and has the following formula.




The PD-173074 compound has the compound structure and chemical name shown below.




1-tert-butyl-3-[6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea.
Measurement of Gene Expression
As noted previously, the measurement of gene expression is performed on a sample, preferably a biological sample, obtained from the patient. For example, the patient may undergo a blood draw or tissue biopsy and the measurement may be made on the resulting sample. Depending upon the technique utilized, the test may be performed on an isolated fraction of the sample or in situ.
Detection of the presence of gene expression of the biomarker of interest and/or detection of the level of alteration in the gene expression compared to baseline may be made utilizing standard techniques.
Detection can be by any appropriate method, including for example, detecting the quantity of mRNA transcribed from the gene or the quantity of cDNA produced from the reverse transcription of the mRNA transcribed from the gene or the quantity of the polypeptide or protein encoded by the gene. These methods can be performed on a sample by sample basis or modified for high throughput analysis. Additionally, databases containing quantitative full or partial transcripts or protein sequences isolated from a cell sample can be searched and analyzed for the presence and amount of transcript or expressed gene product.
In assaying for an alteration in mRNA level, nucleic acid contained in the aforementioned samples is first extracted according to standard methods in the art. For instance, mRNA can be isolated using various lytic enzymes or chemical solutions according to the procedures set forth in Sambrook et al. (1989), supra or extracted by nucleic-acid-binding resins following the accompanying instructions provided by manufactures. The mRNA of the biomarker contained in the extracted nucleic acid sample is then detected by hybridization (e.g. Northern blot analysis) and/or amplification procedures according to methods widely known in the art or based on the methods exemplified herein.
Nucleic acid molecules having at least 10 nucleotides and exhibiting sequence complementarity or homology to the biomarkers described herein find utility as hybridization probes. It is known in the art that a “perfectly matched” probe is not needed for a specific hybridization. Minor changes in probe sequence achieved by substitution, deletion or insertion of a small number of bases do not affect the hybridization specificity. In general, as much as 20% base-pair mismatch (when optimally aligned) can be tolerated.
In certain embodiments, it will be advantageous to employ probes or primers in combination with an appropriate means, such as a label, for detecting hybridization and therefore complementary sequences. A wide variety of appropriate indicator means are known in the art, including fluorescent, radioactive, enzymatic or other ligands, such as avidin/biotin, which are capable of giving a detectable signal. In preferred embodiments, one will likely desire to employ a fluorescent label or an enzyme tag, such as urease, alkaline phosphatase or peroxidase, instead of radioactive or other environmental undesirable reagents. In the case of enzyme tags, calorimetric indicator substrates are known which can be employed to provide a means visible to the human eye or spectrophotometrically, to identify specific hybridization with complementary nucleic acid-containing samples.
Hybridization reactions can be performed under conditions of different “stringency”. Relevant conditions include temperature, ionic strength, time of incubation, the presence of additional solutes in the reaction mixture such as formamide, and the washing procedure. Higher stringency conditions are those conditions, such as higher temperature and lower sodium ion concentration, which require higher minimum complementarity between hybridizing elements for a stable hybridization complex to form. Conditions that increase the stringency of a hybridization reaction are widely known and published in the art. See, for example, (Sambrook, et al., (1989), supra).
Briefly, multiple RNAs are isolated from cell or tissue samples as described above. Optionally, the gene transcripts can be converted to cDNA. A sampling of the biomarker transcript(s) is/are subjected to sequence-specific analysis and quantified. These gene transcript sequence abundances are compared to the baseline.
Alternatively any one of gene copy number, transcription, or translation of a biomarker can be determined using an amplification method such as PCR. General procedures for PCR are taught in MacPherson et al., PCR: A PRACTICAL APPROACH, (IRL Press at Oxford University Press (1991)). However, PCR conditions used for each application reaction are empirically determined. A number of parameters influence the success of a reaction. Among them are annealing temperature and time, extension time, Mg2+ ATP concentration, pH, and the relative concentration of primers, templates, and deoxyribonucleotides. After amplification, the resulting DNA fragments can be detected by agarose gel electrophoresis followed by visualization with ethidium bromide staining and ultraviolet illumination.
In one aspect, the biomarkers are detected and quantitated by hybrization to a probe that specifically hybridizes to the appropriate probe for that biomarker. The probes also can be attached to a solid support for use in high throughput screening assays using methods known in the art. PCT WO 97/10365 and U.S. Pat. Nos. 5,405,783, 5,412,087 and 5,445,934, for example, disclose the construction of high density oligonucleotide chips which can contain one or more of the sequences disclosed herein. Using the methods disclosed in U.S. Pat. Nos. 5,405,783, 5,412,087 and 5,445,934 the probes of this invention are synthesized on a derivatized glass surface. Photoprotected nucleoside phosphoramidites are coupled to the glass surface, selectively deprotected by photolysis through a photolithographic mask, and reacted with a second protected nucleoside phosphoramidite. The coupling/deprotection process is repeated until the desired probe is complete.
In one aspect, the expression level of the biomarker is determined through exposure of a nucleic acid sample to the probe-modified chip. Extracted nucleic acid is labeled, for example, with a fluorescent tag, preferably during an amplification step. Hybridization of the labeled sample is performed at an appropriate stringency level. The degree of probe-nucleic acid hybridization is quantitatively measured using a detection device, such as a confocal microscope. See U.S. Pat. Nos. 5,578,832 and 5,631,734.
In an alternative embodiment, the method is performed by the detecting and comparing of two or more biomarkers that have been pre-determined to be predictive of a therapeutic response. In a yet further embodiment, a plurality of biomarkers, e.g., see Tables I through V, supra, are used in the method of this invention. In these embodiments, the biomarkers or probes that specifically hybridize and recognize the biomarker of interest are arranged on a high density oligonucleotide probe array that provides an effective means of monitoring expression of a multiplicity of genes.
In another preferred embodiment, the methods of this invention are used to monitor expression of the genes which specifically hybridize to the probes of this invention in response to defined stimuli, such as a drug or biologic.
In one embodiment, the hybridized nucleic acids are detected by detecting one or more labels attached to the sample nucleic acids. The labels may be incorporated by any of a number of means well known to those of skill in the art. However, in one aspect, the label is simultaneously incorporated during the amplification step in the preparation of the sample nucleic acid. Thus, for example, polymerase chain reaction (PCR) with labeled primers or labeled nucleotides will provide a labeled amplification product. In a separate embodiment, transcription amplification, as described above, using a labeled nucleotide (e.g. fluorescein-labeled UTP and/or CTP) incorporates a label in to the transcribed nucleic acids.
Alternatively, a label may be added directly to the original nucleic acid sample (e.g., mRNA, polya, mRNA, cDNA, etc.) or to the amplification product after the amplification is completed. Means of attaching labels to nucleic acids are well known to those of skill in the art and include, for example nick translation or end-labeling (e.g. with a labeled RNA) by kinasing of the nucleic acid and subsequent attachment (ligation) of a nucleic acid linker joining the sample nucleic acid to a label (e.g., a fluorophore).
Detectable labels suitable for use in the present invention include any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means. Useful labels in the present invention include biotin for staining with labeled streptavidin conjugate, magnetic beads (e.g., DynabeadsTM), fluorescent dyes (e.g., fluorescein, texas red, rhodamine, green fluorescent protein, and the like), radiolabels (e.g., 3H, 125I, 35S, 14C, or 32P) enzymes (e.g., horse radish peroxidase, alkaline phosphatase and others commonly used in an ELISA), and calorimetric labels such as colloidal gold or colored glass or plastic (e.g., polystyrene, polypropylene, latex, etc.) beads. Patents teaching the use of such labels include U.S. Pat. Nos. 3,817,837; 3,850,752; 3,939,350; 3,996,345; 4,277,437; 4,275,149; and 4,366,241.
Means of detecting such labels are well known to those of skill in the art. Thus, for example, radiolabels may be detected using photographic film or scintillation counters, fluorescent markers may be detected using a photodetector to detect emitted light. Enzymatic labels are typically detected by providing the enzyme with a substrate and detecting the reaction product produced by the action of the enzyme on the substrate, and colorimetric labels are detected by simply visualizing the colored label.
As described in more detail in WO 97/10365, the label may be added to the target (sample) nucleic acid(s) prior to, or after the hybridization. These are detectable labels that are directly attached to or incorporated into the target (sample) nucleic acid prior to hybridization. In contrast, “indirect labels” are joined to the hybrid duplex after hybridization. Often, the indirect label is attached to a binding moiety that has been attached to the target nucleic acid prior to the hybridization. Thus, for example, the target nucleic acid may be biotinylated before the hybridization. After hybridization, an avidin-conjugated fluorophore will bind the biotin bearing hybrid duplexes providing a label that is easily detected. Fore a detailed review of methods of labeling nucleic acids and detecting labeled hybridized nucleic acids see LABORATORY TECHNIQUES IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol. 24: Hybridization with Nucleic Acid Probes, P. Tijssen, ed. Elsevier, N.Y. (1993).
The nucleic acid sample also may be modified prior to hybridization to the high density probe array in order to reduce sample complexity thereby decreasing background signal and improving sensitivity of the measurement using the methods disclosed in WO 97/10365.
Results from the chip assay are typically analyzed using a computer software program. See, for example, EP 0717 113 A2 and WO 95/20681. The hybridization data is read into the program, which calculates the expression level of the targeted gene(s). The figures may be compared against existing data sets of gene expression levels for diseased and healthy individuals. A correlation between the obtained data and that of a set of a predetermined baseline identifies patients likely to be responsive to the therapy.
Also within the scope of this application is a data base useful for the identification of patients likely to respond to a predetermined therapy, e.g., anti-FGFR3 therapy, wherein the database contains a combination of base line gene expression data against which the patient sample can be compared using bioinformatic techniques known in the art.
The pre-determined baseline information is stored in a digital storage medium such that a data processing system for standardized representation of the genes that identify patients that are responsive to therapy. The data processing system is useful to analyze gene expression between two samples. A suitable sample is isolated from the patient and then the genotype or phenotype of the cell or sample is determined using methods known in the art. In one aspect, the nucleic acids of the biomarkers if present in the sample are sequenced and transcribed to code. The sequences (in code form) from the sample are compared with the sequence(s) present in the database using homology search techniques. Greater than 90%, or alternatively, greater than 95% or alternatively, greater than or equal to 97% sequence identity between the test sequence and at least one sequence identified by the biomarkers identified in Tables I through V is a positive indication that the polynucleotide from a biomarker has been isolated from the patient sample.
Expression level of the biomarker can also be determined by examining the protein product. Determining the protein level involves (a) providing a biological sample containing expression product of the biomarker; and (b) measuring the amount of any immunospecific binding that occurs between an antibody that selectively recognizes and binds to the expression product of the biomarker in the sample, in which the amount of immunospecific binding indicates the level of the biomarker expression. This information is then compared to a pre-determined base line and analyzed to identify those patients suitable for therapy.
A variety of techniques are available in the art for protein analysis. They include but are not limited to radioimmunoassays, ELISA (enzyme linked immunoradiometric assays), “sandwich” immunoassays, immunoradiometric assays, in situ immunoassays (using e.g., colloidal gold, enzyme or radioisotope labels), western blot analysis, immunoprecipitation assays, immunoflourescent assays, and PAGE-SDS.
Antibodies that specifically recognize and bind to the protein products of the expression products of the biomarkers are required for immunoassays. These may be purchased from commercial vendors or generated and screened using methods well known in the art. See Harlow and Lane (1988) supra. and Sambrook et al. (1989) supra.
Treatment
Inhibition of activated FGFR3 has been shown to induce apoptosis (Trudel, et al., Blood, 105(7):2941-2948 (2005)) A patient may be beneficially treated by administration of an inhibitor of FGFR3, particularly a tyrosine kinase small molecule inhibitor (SMI) of FGFR3. Thus, treatment according to the invention may constitute administration of one or more small molecule FGFR3 inhibitors, such as those disclosed herein.
Alternatively, the small molecule inhibitors may be used in combination with other treatments. For instance, inhibitors that are not small molecules, e.g. biologicals, polynucleotides, gene therapy, etc. may be used for the ongoing treatment, in some cases, whereas the small molecule FGFR3 inhibitor may be used primarily as an initial aid in identifying candidates.
In another alternative, one inhibitor may be used prior to a gene expression level measurement step and another may be used subsequently.
The methods of the invention are useful for treatment of cellular proliferative disease and particularly neoplastic disease.
One disease model in which the genetic profiling methods taught herein are especially useful is multiple myeloma. A subset of approximately 15-20% of multiple myeloma patients have a chromosomal translocation denoted the t(4; 14) translocation that is associated with the ectopic expression of the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3). The t(4; 14) abnormality is typically diagnosed via a cytogenetic test, such as a fluorescence in situ hybridization (FISH) analysis, performed on a bone marrow aspirate taken from the patient. The t(4; 14) multiple myeloma patient has a poor prognosis, but the methods taught herein offer new hope in that they may be employed to great advantage to identify such patients for treatment with an FGFR3 inhibitor, monitor response to treatment in such patients, as well as to aid in the development of new and/or optimized FGFR3 inhibitors.
Therapeutic agents utilized according to this invention, include, but are not limited to small molecules. They may be polynucleotides, peptides, antibodies, antigen presenting cells and include immune effector cells that specifically recognize and lyse cells expressing the gene of interest. One can determine if a subject or patient will be beneficially treated by the use of agents by screening one or more of the agents against tumor cells isolated from the subject or patient using methods known in the art.
Various delivery systems are known and can be used to administer a therapeutic agent in accordance with the methods of the invention, e.g., encapsulation in liposomes, microparticles, microcapsules, expression by recombinant cells, receptor-mediated endocytosis (See e.g., Wu and Wu (1987) J. Biol. Chem. 262:4429-4432), construction of a therapeutic nucleic acid as part of a retroviral or other vector, etc. Methods of delivery include but are not limited to intra-arterial, intra-muscular, intravenous, intranasal and oral routes. In a specific embodiment, it may be desirable to administer pharmaceutical compositions locally to the area in need of treatment; this may be achieved by, for example, and not by way of limitation, local infusion during surgery, by injection or by means of a catheter.
Administration in vivo can be effected in one dose, continuously or intermittently throughout the course of treatment. Methods of determining the most effective means and dosage of administration are well known to those of skill in the art and will vary with the composition used for therapy, the purpose of the therapy, the target cell being treated and the subject being treated. Single or multiple administrations can be carried out with the dose level and pattern being selected by the treating physician. Suitable dosage formulations and methods of administering the agents may be empirically adjusted.
Pharmaceutical compositions utilized according to the methods of the invention can be administered orally, intranasally, parenterally or by inhalation therapy, and may take the form of tablets, lozenges, granules, capsules, pills, ampoules, suppositories or aerosol form. They may also take the form of suspensions, solutions and emulsions of the active ingredient in aqueous or nonaqueous diluents, syrups, granulates or powders. In addition to the key active ingredients, the pharmaceutical compositions can also contain other pharmaceutically active compounds or a plurality of compositions of the invention.
More particularly, an agent administered according to the invention may be administered for therapy by any suitable route including oral, rectal, nasal, topical (including transdermal, aerosol, buccal and sublingual), vaginal, parental (including subcutaneous, intramuscular, intravenous and intradermal) and pulmonary. It will also be appreciated that the preferred route will vary with the condition and age of the recipient and the disease being treated.
Ideally, the agent should be administered to achieve peak concentrations of the active compound at sites of disease. This may be achieved, for example, by the intravenous injection of the agent, optionally in saline or orally administered, for example, as a tablet, capsule or syrup containing the active ingredient. Desirable blood levels of the agent may be maintained by a continuous infusion to provide a therapeutic amount of the active ingredient within disease tissue. The use of operative combinations is contemplated to provide therapeutic combinations requiring a lower total dosage of each component antiviral agent than may be required when each individual therapeutic compound or drug is used alone, thereby reducing adverse effects.
While it is possible for the agent to be administered alone, it is preferable to present it as a pharmaceutical formulation comprising at least one active ingredient, as defined above, together with one or more pharmaceutically acceptable carriers therefor and optionally other therapeutic agents. Each carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation and not injurious to the patient.
Formulations include those suitable for oral, rectal, nasal, topical (including transdermal, buccal and sublingual), vaginal, parenteral (including subcutaneous, intramuscular, intravenous and intradermal) and pulmonary administration. The formulations may conveniently be presented in unit dosage form and may be prepared by any methods well known in the art of pharmacy. Such methods include the step of bringing into association the active ingredient with the carrier which constitutes one or more accessory ingredients. In general, the formulations are prepared by uniformly and intimately bringing into association the active ingredient with liquid carriers or finely divided solid carriers or both and then, if necessary, shaping the product.
Formulations suitable for oral administration may be presented as discrete units such as capsules, cachets or tablets, each containing a predetermined amount of the active ingredient; as a powder or granules; as a solution or suspension in an aqueous or non-aqueous liquid; or as an oil-in-water liquid emulsion or a water-in-oil liquid emulsion. The active ingredient may also be presented a bolus, electuary or paste.
A tablet may be made by compression or molding, optionally with one or more accessory ingredients. Compressed tablets may be prepared by compressing in a suitable machine the active ingredient in a free-flowing form such as a powder or granules, optionally mixed with a binder (e.g., povidone, gelatin, hydroxypropylmethyl cellulose), lubricant, inert diluent, preservative, disintegrant (e.g., sodium starch glycolate, cross-linked povidone, cross-linked sodium carboxymethyl cellulose) surface-active or dispersing agent. Molded tablets may be made by molding in a suitable machine a mixture of the powdered compound moistened with an inert liquid diluent. The tablets may optionally be coated or scored and may be formulated so as to provide slow or controlled release of the active ingredient therein using, for example, hydroxypropylmethyl cellulose in varying proportions to provide the desired release profile. Tablets may optionally be provided with an enteric coating, to provide release in parts of the gut other than the stomach.
Formulations suitable for topical administration in the mouth include lozenges comprising the active ingredient in a flavored basis, usually sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert basis such as gelatin and glycerin or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier.
Pharmaceutical compositions for topical administration according to the present invention may be formulated as an ointment, cream, suspension, lotion, powder, solution, past, gel, spray, aerosol or oil. Alternatively, a formulation may comprise a patch or a dressing such as a bandage or adhesive plaster impregnated with active ingredients and optionally one or more excipients or diluents.
If desired, the aqueous phase of the cream base may include, for example, at least about 30% w/w of a polyhydric alcohol, i.e., an alcohol having two or more hydroxyl groups such as propylene glycol, butane-1,3-diol, mannitol, sorbitol, glycerol and polyethylene glycol and mixtures thereof. The topical formulations may desirably include a compound which enhances absorption or penetration of the agent through the skin or other affected areas. Examples of such dermal penetration enhancers include dimethylsulfoxide and related analogues.
The oily phase of the emulsions of a composition used according to this invention may be constituted from known ingredients in a known manner. While this phase may comprise merely an emulsifier (otherwise known as an emulgent), it desirably comprises a mixture of at lease one emulsifier with a fat or an oil or with both a fat and an oil. Preferably, a hydrophilic emulsifier is included together with a lipophilic emulsifier which acts as a stabilizer. It is also preferred to include both an oil and a fat. Together, the emulsifier(s) with or without stabilizer(s) make up the so-called emulsifying wax, and the wax together with the oil and/or fat make up the so-called emulsifying ointment base which forms the oily dispersed phase of the cream formulations.
Emulgents and emulsion stabilizers suitable for use in the formulation of the present invention include Tween 60, Span 80, cetostearyl alcohol, myristyl alcohol, glyceryl monostearate and sodium lauryl sulphate.
The choice of suitable oils or fats for the formulation is based on achieving the desired cosmetic properties, since the solubility of the active compound in most oils likely to be used in pharmaceutical emulsion formulations is very low. Thus the cream should preferably be a non-greasy, non-staining and washable product with suitable consistency to avoid leakage from tubes or other containers. Straight or branched chain, mono- or dibasic alkyl esters such as di-isoadipate, isocetyl stearate, propylene glycol diester of coconut fatty acids, isopropyl myristate, decyl oleate, isopropyl palmitate, butyl stearate, 2-ethylhexyl palmitate or a blend of branched chain esters known as Crodamol CAP may be used, the last three being preferred esters. These may be used alone or in combination depending on the properties required.
Alternatively, high melting point lipids such as white soft paraffin and/or liquid paraffin or other mineral oils can be used.
Formulations suitable for topical administration to the eye also include eye drops wherein the active ingredient is dissolved or suspended in a suitable carrier, especially an aqueous solvent for the agent.
Formulations for rectal administration may be presented as a suppository with a suitable base comprising, for example, cocoa butter or a salicylate.
Formulations suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or spray formulations containing in addition to the agent, such carriers as are known in the art to be appropriate.
Formulations suitable for nasal administration, wherein the carrier is a solid, include a coarse powder having a particle size, for example, in the range of about 20 to about 500 microns which is administered in the manner in which snuff is taken, i.e., by rapid inhalation through the nasal passage from a container of the powder held close up to the nose. Suitable formulations wherein the carrier is a liquid for administration as, for example, nasal spray, nasal drops or by aerosol administration by nebulizer, include aqueous or oily solutions of the agent.
Formulations suitable for parenteral administration include aqueous and non-aqueous isotonic sterile injection solutions which may contain anti-oxidants, buffers, bacteriostats and solutes which render the formulation isotonic with the blood of the intended recipient; and aqueous and non-aqueous sterile suspensions which may include suspending agents, thickening agents and liposomes or other microparticulate systems which are designed to target the compound to blood components or one or more organs. The formulations may be presented in unit-dose or multi-dose sealed containers, for example, ampoules and vials, and may be stored in a freeze-dried (lyophilized) condition requiring only the addition of the sterile liquid carrier, for example water for injections, immediately prior to use. Extemporaneous injection solutions and suspensions may be prepared from sterile powders, granules and tablets of the kind previously described.
Preferred unit dosage formulations are those containing a daily dose or unit, daily subdose, as herein above-recited, or an appropriate fraction thereof, of an agent.
Experimental Example
Transcriptional activity was assessed by measuring levels of messenger RNA (mRNA) in cells derived from human multiple myeloma tumors using Affymetrix HG-U133-Plus-2 GeneChips.
Expression of mRNA in cells treated with the small molecule inhibitors SU-5402, PD-173074 (both Pfizer Inc.) and CHIR-258 (Chiron Corp.), with FGF ligand, or with FGFR3 silencing RNA (siRNA) was quantitatively compared to expression in untreated cells (or cells treated with a scrambled siRNA control in the latter case). Specific differences and similarities to the other FGFR3 inhibitors were compared with CHIR-258.
The following multiple myeloma cell lines were used:

    
    
        KMS11: Ras WT, FGFR3Y373C mutant; sensitive to CHIR-258 treatment
        KMS18: Ras WT, FGFR3G384D mutant; sensitive to CHIR-258 treatment
        H929: N13 Ras mutant, FGFR3 wild-type (WT); resistant to CHIR-258 treatment
        U266: Ras WT, FGFR3 negative; resistant to CHIR-258 treatment
        UTMC2: Ras WT, FGFR3WT; resistant to CHIR-258 treatment
    
    


Bioinformatics analysis was performed on the raw data to provide the results.
Changes in gene expression level in response to the various FGFR3 inhibitors tested and deemed to be of statistical significance were utilized to generate Table I disclosed herein, and its various subsets. Within the parameters of this experiment, the biomarkers of Table I generally correlate with alterations in expression level of one-and-a-half-fold or greater, whereas the biomarkers of Table II generally correlate with alterations in expression level of two-fold or greater, and the biomarkers of Table III generally correlate with alterations in expression level of four-fold or greater. Table IV was generated with data showing alterations in gene expression in response to FGFR3 inhibition in the relevant cell lines of the experiment by the preferred compound, CHIR-258. Table V was generated with data showing alterations in gene expression in response to FGFR3 inhibition in the relevant cell lines of the experiment by the preferred compound, CHIR-258, but not to any significant extent by the other small molecule inhibitors tested.

## Claims

1. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising:
testing a sample obtained from the patient after administration of the inhibitor to measure gene expression of at least one biomarker which is CCL3,
wherein detection of an alteration in level of expression compared to a baseline gene expression measurement of the at least one biomarker is indicative of the candidacy of the patient for the treatment, and
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

2. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising:
testing a sample obtained from a patient to measure gene expression of at least one biomarker which is CCL3,
wherein detection of the presence of gene expression of the at least one biomarker is indicative of the candidacy of the patient for the treatment.

3. A method of monitoring response of a patient in need thereof to treatment for a cell proliferative disorder, the method comprising:
administering an amount of an inhibitor of FGFR3 to the patient,
testing a sample obtained from the patient after the administration of the inhibitor to measure gene expression of at least one biomarker which is CCL3,
wherein detection of an alteration in level of expression of the at least one biomarker as compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

4. A method of monitoring response of a patient to treatment by an inhibitor of FGFR3 for a cell proliferative disorder, the method comprising:
testing a sample obtained from the patient after administration of the inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3,
wherein detection of an alteration in level of expression of the at least one biomarker compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

5. A method of utilizing a biomarker in treatment of a cell proliferative disorder in a patient, the method comprising
testing a sample obtained from the patient after administration of an inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3,
wherein the patient is subsequently administered the same or a different inhibitor of FGFR3 provided alteration of the level of expression of the at least one biomarker is detected upon administration of the initial inhibitor.

6. A method of adjusting a dosage amount of an inhibitor of FGFR3 for treatment of a cell proliferative disorder in a patient, the method comprising:
monitoring gene expression of at least one biomarker which is CCL3 after the administration of an initial amount of the inhibitor, and
adjusting the amount for subsequent administration of the inhibitor to the patient based upon the level of alteration of the expression of the biomarker or biomarkers that has occurred upon administration of the initial amount.

7. A method of utilizing a biomarker to identify an FGFR3 inhibitory compound for potential treatment of multiple myeloma or to guide a decision to progress an FGFR3 inhibitory compound to further development for treatment of multiple myeloma, the method comprising:
contacting the compound with a KMS18 or KMS11 cell culture, and
testing a portion of the cell culture to measure gene expression of at least one biomarker which is CCL3,
wherein detection of an alteration in expression of the at least one biomarker compared to baseline gene expression measurement is indicative of an identification of the compound for treatment or a favorable decision to progress the compound for further development, and
wherein the baseline gene expression measurement is gene expression measured in cell culture prior to the contacting.

8. A method of selecting an appropriate inhibitor of FGFR3 to administer to a patient in need of treatment with said inhibitor, the method comprising:
testing a sample obtained from the patient after administration of an initial inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3,
wherein the patient is subsequently administered the initial inhibitor of FGFR3 provided alteration of the level of expression of the at least one biomarker is detected upon administration of the initial inhibitor.

9. A method of utilizing CCL3 to identify an FGFR3 inhibitory compound for potential treatment of a cell proliferative disorder, the method comprising:
contacting the compound with a cell line or tissue associated with the disorder, and
testing a portion of the cell culture or tissue after the contacting to measure gene expression of at least one biomarker which is CCL3 that has been altered compared to a baseline gene expression measurement,
wherein detection of an alteration in expression of the at least one biomarker is indicative of an identification of the compound for treatment, and
wherein the baseline gene expression measurement is the gene expression measured from the cell or tissue prior to the contacting.

10. The method of claim 1, wherein the measurement of gene expression is made by detecting the quantity of RNA transcribed by the biomarker.

11. The method of claim 1, wherein the measurement of gene expression is made by detecting the quantity of DNA produced from reverse transcription of an RNA transcribed by the biomarker.

12. The method of claim 1, wherein the measurement of gene expression is made by detecting a polypeptide or protein encoded by the biomarker.

13. The method of claim 1, wherein the at least one biomarker is operably linked to a gene chip.

14. The method of claim 1, wherein the at least one biomarker is represented in computer readable format.

15. The method of claim 1, wherein the testing comprises contacting the sample with a gene chip comprising CCL3.

16. The method of claim 1, wherein the detecting step comprises comparing the gene expression level of the biomarker with a gene database.

17. The method of claim 1, wherein the treatment comprises administration of a therapeutically effective amount of the same or a different inhibitor of FGFR3 to the patient.

18. The method of claim 1, wherein the treatment is for a neoplastic disease.

19. The method of claim 1, wherein the treatment is for multiple myeloma.

20. The method of claim 1, wherein the treatment is for t(4; 14) multiple myeloma.

21. The method of claim 1, wherein the inhibitor is selected from the group consisting of CHIR-258, SU-5402, and PD-173074.

22. The method of claim 1, wherein the inhibitor is CHIR-258.

23. The method of claim 1, wherein the at least one biomarker further comprises a biomarker selected from the group consisting of LOC150271, CD48, DUSP4, and ITGB7.

24. The method of claim 1, further comprising establishing a baseline gene expression measurement level for the patient prior to administering the FGFR3 inhibitor.

25. The method of claim 1, wherein the biomarker is not any or all of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A.

26. The method of claim 3, wherein the administration is repeated before the step of testing a sample obtained from the patient.

27. The method of claim 3, wherein the inhibitor of FGFR3 is administered in a therapeutically effective amount.

28. The method of claim 5, wherein the initial inhibitor and the subsequently administered inhibitor are each selected from the group consisting of CHIR-258, SU-5402, and PD-173074.

29. The method of claim 5, wherein the initial inhibitor is CHIR-258.

30. The method of claim 5, wherein the subsequently administered inhibitor is CHIR-258.

31. The method of claim 6, wherein the monitoring comprises contacting the sample with a gene chip comprising CCL3 and comparing the gene expression level of CCL3 with a gene database.

32. The method of any one of claims 1-5 or 6-9, wherein the at least one biomarker further comprises one or more biomarkers selected Table I.









TABLE I





ENTREZ GENE ID
GENE SYMBOL
GENE DESCRIPTION

















200734
SPRED2
sprouty-related, EVH1 domain containing 2


117854
TRIM6
tripartite motif-containing 6


1846
DUSP4
dual specificity phosphatase 4


894
CCND2
cyclin D2


6241
RRM2
ribonucleotide reductase M2 polypeptide


4821
NKX2-2
NK2 transcription factor related, locus 2 (Drosophila)


3037
HAS2
hyaluronan synthase 2


990
CDC6
CDC6 cell division cycle 6 homolog (S. cerevisiae)


57405
SPBC25
spindle pole body component 25 homolog (S. cerevisiae)


934
CD24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)


55165
C10orf3
chromosome 10 open reading frame 3


55388
MCM10
MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)


79019
C22orf18
chromosome 22 open reading frame 18


9768
KIAA0101
KIAA0101


51659
Pfs2
DNA replication complex GINS protein PSF2


4605
MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2


161742
SPRED1
sprouty-related, EVH1 domain containing 1


4175
MCM6
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)


11130
ZWINT
ZW10 interactor


26298
EHF
ets homologous factor


7117
TMSL3
thymosin-like 3


890
CCNA2
cyclin A2


79075
DCC1
defective in sister chromatid cohesion homolog 1 (S. cerevisiae)


83879
CDCA7
cell division cycle associated 7


22873
DZIP1
DAZ interacting protein 1


51514
DTL
denticleless homolog (Drosophila)


55789
DEPDC1B
DEP domain containing 1B


55355
DKFZp762E1312
hypothetical protein DKFZp762E1312


10052
GJA7
gap junction protein, alpha 7, 45kDa (connexin 45)


146909
LOC146909
hypothetical protein LOC146909


113130
CDCA5
cell division cycle associated 5


1017
CDK2
cyclin-dependent kinase 2


4176
MCM7
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)


81610
C20orf129
chromosome 20 open reading frame 129


9833
MELK
maternal embryonic leucine zipper kinase


29128
UHRF1
ubiquitin-like, containing PHD and RING finger domains, 1


4171
MCM2
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)


79801
SHCBP1
SHC SH2-domain binding protein 1


28231
SLCO4A1
solute carrier organic anion transporter family, member 4A1


113115
FAM54A
family with sequence similarity 54, member A


22974
TPX2
TPX2, microtubule-associated protein homolog (Xenopus laevis)


9232
PTTG1
pituitary tumor-transforming 1


137392
LOC137392
similar to CG6405 gene product


195828
ZNF367
zinc finger protein 367


4288
MKI67
antigen identified by monoclonal antibody Ki-67


701
BUB1B
BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)


9928
KIF14
kinesin family member 14


3832
KIF11
kinesin family member 11


11065
UBE2C
ubiquitin-conjugating enzyme E2C


9837
PSF1
DNA replication complex GINS protein PSF1


387103
C6orf173
chromosome 6 open reading frame 173


1870
E2F2
E2F transcription factor 2


79733
E2F8
E2F transcription factor 8


991
CDC20
CDC20 cell division cycle 20 homolog (S. cerevisiae)


3014
H2AFX
H2A histone family, member X


10112
KIF20A
kinesin family member 20A


993
CDC25A
cell division cycle 25A


24137
KIF4A
kinesin family member 4A


80144
FRAS1
Fraser syndrome 1


55010
FLJ20641
hypothetical protein FLJ20641


9319
TRIP13 
thyroid hormone receptor interactor 13


9355
LHX2
LIM homeobox 2


7153
TOP2A
topoisomerase (DNA) II alpha 170kDa


4174
MCM5
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)


55215
FLJ10719
hypothetical protein FLJ10719


11013
TMSL8
thymosin-like 8


5983
RFC3
replication factor C (activator 1) 3, 38kDa


1063
CENPF
centromere protein F, 350/400ka (mitosin)


3683
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1;




alpha polypeptide)


2237
FEN1
flap structure-specific endonuclease 1


27338
UBE2S
ubiquitin-conjugating enzyme E2S


4001
LMNB1
lamin B1


29089
UBE2T
ubiquitin-conjugating enzyme E2T (putative)


55839
BM039
uncharacterized bone marrow protein BM039


2115
ETV1
ets variant gene 1


440279
UNC13C
unc-13 homolog C (C. elegans)


962
CD48
CD48 antigen (B-cell membrane protein)


54910
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain




(TM) and short cytoplasmic domain, (semaphorin) 4C


1902
EDG2
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2


64946
CENPH
centromere protein H


157570
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)


389835
FAM72A
family with sequence similarity 72, member A


144455
E2F7
E2F transcription factor 7


51512
GTSE1
G-2 and S-phase expressed 1


7298
TYMS
thymidylate synthetase


7374
UNG
uracil-DNA glycosylase


5578
PRKCA
protein kinase C, alpha


672
BRCA1
breast cancer 1, early onset


84952
CGNL1
cingulin-like 1


10252
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)


79682
MLF1IP
MLF1 interacting protein


8851
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)


10635
RAD51AP1 
RAD51 associated protein 1


22998
KIAA1102
KIAA1102 protein


148203
LOC148203
hypothetical protein LOC148203


7465
WEE1
WEE1 homolog (S. pombe)


83540
CDCA1
cell division cycle associated 1


3070
HELLS
helicase, lymphoid-specific


891
CCNB1
cyclin B1


6790
STK6
serine/threonine kinase 6


56992
KIF15
kinesin family member 15


7112
TMPO
thymopoietin


63901
FLJ22794
FLJ22794 protein


9493
KIF23
kinesin family member 23


9133
CCNB2
cyclin B2


4173
MCM4
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)


7083
TK1
thymidine kinase 1, soluble


983
CDC2
cell division cycle 2, G1 to S and G2 to M


11339
OIP5
Opa interacting protein 5


51203
NUSAP1
nucleolar and spindle associated protein 1


5111
PCNA
proliferating cell nuclear antigen


11004
KIF2C
kinesin family member 2C


54443
ANLN
anillin, actin binding protein (scraps homolog, Drosophila)


83461
CDCA3
cell division cycle associated 3


4085
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)


9201
DCAMKL1 
doublecortin and CaM kinase-like 1


1111
CHEK1
CHK1 checkpoint homolog (S. pombe)


9055
PRC1
protein regulator of cytokinesis 1


7804
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor


4915
NTRK2
neurotrophic tyrosine kinase, receptor, type 2


28951
TRIB2
tribbles homolog 2 (Drosophila)


4281
MID1
midline 1 (Opitz/BBB syndrome)


3148
HMGB2
high-mobility group box 2


3161
HMMR
hyaluronan-mediated motility receptor (RHAMM)


10276
NET1
neuroepithelial cell transforming gene 1


29028
ATAD2
ATPase family, AAA domain containing 2


1062
CENPE
centromere protein E, 312kDa


1491
CTH
cystathionase (cystathionine gamma-lyase)


10615
SPAG5
sperm associated antigen 5


64581
CLEC7A
C-type lectin domain family 7, member A


10592
SMC2L1
SMC2 structural maintenance of chromosomes 2-like 1 (yeast)


332
BIRC5
baculoviral IAP repeat-containing 5 (survivin)


4172
MCM3
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)


64105
FKSG14 
leucine zipper protein FKSG14


64151
HCAP-G 
chromosome condensation protein G


1163
CKS1B
CDC28 protein kinase regulatory subunit 1B


122769
PPIL5 
peptidylprolyl isomerase (cyclophilin)-like 5


3398
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein


22822
PHLDA1 
pleckstrin homology-like domain, family A, member 1


1718
DHCR24 
24-dehydrocholesterol reductase


145482
ZADH1
zinc binding alcohol dehydrogenase, domain containing 1


1847
DUSP5
dual specificity phosphatase 5


26271
FBXO5
F-box protein 5


9212
AURKB
aurora kinase B


29968
PSAT1
phosphoserine aminotransferase 1


26147
PHF19
PHD finger protein 19


55635
DEPDC1
DEP domain containing 1


10403
KNTC2
kinetochore associated 2


64081
MAWBP
MAWD binding protein


84858
ZNF503
zinc finger protein 503


55723
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)


7272
TTK
TTK protein kinase


9535
GMFG
glia maturation factor, gamma


1058
CENPA
centromere protein A, 17kDa


84515
MCM8
MCM8 minichromosome maintenance deficient 8 (S. cerevisiae)


54069
C21orf45
chromosome 21 open reading frame 45


5984
RFC4
replication factor C (activator 1) 4, 37kDa


389831
LOC389831
hypothetical gene supported by AL713796


157313
CDCA2
cell division cycle associated 2


29127
RACGAP1
Rac GTPase activating protein 1


55872
PBK
PDZ binding kinase


4678
NASP
nuclear autoantigenic sperm protein (histone-binding)


7171
TPM4
tropomyosin 4


7443
VRK1
vaccinia related kinase 1


699
BUB1
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)


3925
STMN1
stathmin 1/oncoprotein 18


865
CBFB
core-binding factor, beta subunit


399664
RKHD1
ring finger and KH domain containing 1


11168
PSIP1
PC4 and SFRS1 interacting protein 1


84057
GAJ
GAJ protein


57082
CASC5
cancer susceptibility candidate 5


23286
KIBRA
KIBRA protein


285513
LOC285513
hypothetical protein LOC285513


259266
ASPM
asp (abnormal spindle)-like, microcephaly associated (Drosophila)


150468
FLJ40629
hypothetical protein FLJ40629


6659
SOX4
SRY (sex determining region Y)-box 4


51053
GMNN
geminin, DNA replication inhibitor


3159
HMGA1
high mobility group AT-hook 1


81620
CDT1
DNA replication factor


11332
BACH
brain acyl-CoA hydrolase


4751
NEK2
NIMA (never in mitosis gene a)-related kinase 2


1033
CDKN3
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)


8864
PER2
period homolog 2 (Drosophila)


3418
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial


63979
FIGNL1
fidgetin-like 1


55646
LYAR
hypothetical protein FLJ20425


91614
LOC91614
novel 58.3 KDA protein


8630
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6


1038
CDR1
cerebellar degeneration-related protein 1, 34kDa


6941
TCF19
transcription factor 19 (SC1)


256435S
T6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide




alpha-2,6-sialyltransferase 3


54892
LUZP5
leucine zipper protein 5


4603
MYBL1
v-myb myeloblastosis viral oncogene homolog (avian)-like 1


1719
DHFR
dihydrofolate reductase


170954
KIAA1949
KIAA1949


7903
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4


9787
DLG7
discs, large homolog 7 (Drosophila)


56935
FN5
FN5 protein


3015
H2AFZ
H2A histone family, member Z


10189
THOC4
THO complex 4


494143
LOC494143
similar to RIKEN cDNA 2510006C20 gene


6240
RRM1
ribonucleotide reductase M1 polypeptide


1894
ECT2
epithelial cell transforming sequence 2 oncogene


7913
DEK
DEK oncogene (DNA binding)


2146
EZH2
enhancer of zeste homolog 2 (Drosophila)


55055
FLJ10036
Zwilch


11073
TOPBP1
topoisomerase (DNA) II binding protein 1


55502
HES6
hairy and enhancer of split 6 (Drosophila)


55247
NEIL3
nei endonuclease VIII-like 3 (E. coli)


54885
FLJ20298
FLJ20298 protein


83641
C10orf45
chromosome 10 open reading frame 45


64919
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)


26095
PTPN20
protein tyrosine phosphatase, non-receptor type 20


23590
TPRT
trans-prenyltransferase


387882
LOC387882
hypothetical protein


51232
CRIM1
cysteine-rich motor neuron 1


801
CALM1
calmodulin 1 (phosphorylase kinase, delta)


55964
SEPT3
septin 3


493861
EID3
E1A-like inhibitor of differentiation 3


29980
DONSON
downstream neighbor of SON


147138
EVER2
epidermodysplasia verruciformis 2


80150
ASRGL1
asparaginase like 1


5985
RFC5
replication factor C (activator 1) 5, 36.5kDa


51155
HN1
hematological and neurological expressed 1


7004
TEAD4
TEA domain family member 4


4325
MMP16
matrix metalloproteinase 16 (membrane-inserted)


203068
TUBB
tubulin, beta polypeptide


4602
MYB
v-myb myeloblastosis viral oncogene homolog (avian)


55706
TMEM48
transmembrane protein 48


348235
FAM33A
family with sequence similarity 33, member A


8871
SYNJ2
synaptojanin 2


81563
C1orf21
chromosome 1 open reading frame 21


51192
CKLF
chemokine-like factor


2326
FMO1
flavin containing monooxygenase 1


91057
NY-REN-41
NY-REN-41 antigen


10376
K-ALPHA-1
tubulin, alpha, ubiquitous


23234
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9


5982
RFC2
replication factor C (activator 1) 2, 40kDa


51063
FAM26B
family with sequence similarity 26, member B


9953
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1


79723
SUV39H2
suppressor of variegation 3-9 homolog 2 (Drosophila)


79596
C13orf7
chromosome 13 open reading frame 7


23165
NUP205
nucleoporin 205kDa


9530
BAG4
BCL2-associated athanogene 4


3146
HMGB1
high-mobility group box 1


445815
PALM2-AKAP2
PALM2-AKAP2 protein


5557
PRIM1
primase, polypeptide 1, 49kDa


2983
GUCY1B3
guanylate cyclase 1, soluble, beta 3


51776
ZAK
sterile alpha motif and leucine zipper containing kinase AZK


10926
ASK
activator of S phase kinase


8833
GMPS
guanine monphosphate synthetase


84930
MASTL
microtubule associated serine/threonine kinase-like


90417
C15orf23
chromosome 15 open reading frame 23


8530
CST7
cystatin F (leukocystatin)


9532
BAG2
BCL2-associated athanogene 2


23310
hCAP-D3
KIAA0056 protein


283991
MGC29814
hypothetical protein MGC29814


91607
FLJ34922
hypothetical protein FLJ34922


7398
USP1
ubiquitin specific protease 1


2669
GEM
GTP binding protein overexpressed in skeletal muscle


151246
SGOL2
shugoshin-like 2 (S. pombe)


23421
ITGB3BP
integrin beta 3 binding protein (beta3-endonexin)


84969
C20orf100
chromosome 20 open reading frame 100


201725
LOC201725
hypothetical protein LOC201725


5361
PLXNA1
plexin A1


3708
ITPR1
inositol 1,4,5-triphosphate receptor, type 1


55740
ENAH
enabled homolog (Drosophila)


126731
C1orf96
chromosome 1 open reading frame 96


57037
ANKMY2
ankyrin repeat and MYND domain containing 2


23331
KIAA1043
KIAA1043 protein


3930
LBR
lamin B receptor


3838
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)


1230
CCR1
chemokine (C-C motif) receptor 1


2200
FBN1
fibrillin 1 (Marfan syndrome)


6867
TACC1
transforming, acidic coiled-coil containing protein 1


27115
PDE7B
phosphodiesterase 7B


11151
CORO1A
coronin, actin binding protein, 1A


6385
SDC4
syndecan 4 (amphiglycan, ryudocan)


3182
HNRPAB
heterogeneous nuclear ribonucleoprotein A/B


5757
PTMA
prothymosin, alpha (gene sequence 28)


83990
BRIP1
BRCA1 interacting protein C-terminal helicase 1


9830
TRIM14
tripartite motif-containing 14


57761
TRIB3
tribbles homolog 3 (Drosophila)


2026
ENO2
enolase 2 (gamma, neuronal)


8727
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1


5880
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


864
RUNX3
runt-related transcription factor 3


10950
BTG3
BTG family, member 3


81539
SLC38A1
solute carrier family 38, member 1


26051
PPP1R16B
protein phosphatase 1, regulatory (inhibitor) subunit 16B


5793
PTPRG
protein tyrosine phosphatase, receptor type, G


2767
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)


55013
FLJ20647
hypothetical protein FLJ20647


4885
NPTX2
neuronal pentraxin II


79710
MORC4
MORC family CW-type zinc finger 4


490
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1


2956
MSH6
mutS homolog 6 (E. coli)


6611
SMS
spermine synthase


6627
SNRPA1
small nuclear ribonucleoprotein polypeptide A'


1434
CSE1L
CSE1 chromosome segregation 1-like (yeast)


7371
UCK2
uridine-cytidine kinase 2


7277
TUBA1
tubulin, alpha 1 (testis specific)


1786
DNMT1
DNA (cytosine-5-)-methyltransferase 1


54801
FAM29A
family with sequence similarity 29, member A


54908
FLJ20364
hypothetical protein FLJ20364


119467
MGC32871
hypothetical protein MGC32871


90390
THRAP6
thyroid hormone receptor associated protein 6


60468
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2


6510
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5


6628
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1


205
AK3L1
adenylate kinase 3-like 1


116832
RPL39L
ribosomal protein L39-like


79902
PCNT1
pericentrin 1


54962
FLJ20516
timeless-interacting protein


23279
NUP160
nucleoporin 160kDa


23046
KIF21B
kinesin family member 21B


2288
FKBP4
FK506 binding protein 4, 59kDa


5698
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)


10160
FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)


8502
PKP4
plakophilin 4


10675
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)


29899
GPSM2
G-protein signalling modulator 2 (AGS3-like, C. elegans)


10602
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3


8243
SMC1L1
SMC1 structural maintenance of chromosomes 1-like 1 (yeast)


6347
CCL2
chemokine (C-C motif) ligand 2


5932
RBBP8
retinoblastoma binding protein 8


6877
TAF5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa


10801
SEPT9
septin 9


55536
CDCA7L
cell division cycle associated 7-like


11340
EXOSC8
exosome component 8


5873
RAB27A
RAB27A, member RAS oncogene family


53354
PANK1
pantothenate kinase 1


2534
FYN
FYN oncogene related to SRC, FGR, YES


55166
C6orf139
chromosome 6 open reading frame 139


27346
MAC30
hypothetical protein MAC30


79037
MGC2463
hypothetical protein MGC2463


116496
C1orf24
chromosome 1 open reading frame 24


84314
MGC10744
hypothetical protein MGC10744


23531
MMD
monocyte to macrophage differentiation-associated


6558
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2


64282
PAPD5
PAP associated domain containing 5


55636
CHD7
chromodomain helicase DNA binding protein 7


55026
FLJ20716
hypothetical protein FLJ20716


22929
SEPHS1
selenophosphate synthetase 1


10541
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B


79621
FLJ11712
hypothetical protein FLJ11712


6432
SFRS7
splicing factor, arginine/serine-rich 7, 35kDa


5214
PFKP
phosphofructokinase, platelet


26031
OSBPL3
oxysterol binding protein-like 3


1102
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain




containing protein 2


6929
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)


6632
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide 16kDa


2047
EPHB1
EPH receptor B1


5168
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)


55257
C20orf20
chromosome 20 open reading frame 20


81611
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E


23246
BOP1
block of proliferation 1


23526
HA-1
minor histocompatibility antigen HA-1


84250
ANKRD32
ankyrin repeat domain 32


6999
TDO2
tryptophan 2,3-dioxygenase


8317
CDC7
CDC7 cell division cycle 7 (S. cerevisiae)


55752
SEPT11
septin 11


39
ACAT2
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)


54830
FLJ20130
hypothetical protein FLJ20130


83732
RIOK1
RIO kinase 1 (yeast)


10808
HSPH1
heat shock 105kDa/110kDa protein 1


489
ATP2A3
ATPase, Ca++ transporting, ubiquitous


3251
HPRT1
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)


10051
SMC4L1
SMC4 structural maintenance of chromosomes 4-like 1 (yeast)


55816
DOK5
docking protein 5


3676
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)


8819
SAP30
sin3-associated polypeptide, 30kDa


4436
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)


10212
DDX39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39


5889
RAD51C
RAD51 homolog C (S. cerevisiae)


134111
FLJ25076
similar to CG4502-PA


51377
UCHL5
ubiquitin carboxyl-terminal hydrolase L5


6657
SOX2
SRY (sex determining region Y)-box 2


241
ALOX5AP
arachidonate 5-lipoxygenase-activating protein


79888
FLJ12443
hypothetical protein FLJ12443


1368
CPM
carboxypeptidase M


397
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta


3336
HSPE1
heat shock 10kDa protein 1 (chaperonin 10)


2104
ESRRG
estrogen-related receptor gamma


2171
FABP5
fatty acid binding protein 5 (psoriasis-associated)


6574
SLC20A1
solute carrier family 20 (phosphate transporter), member 1


2743
GLRB
glycine receptor, beta


1019
CDK4
cyclin-dependent kinase 4


9295
SFRS11
splicing factor, arginine/serine-rich 11


56952
PRTFDC1
phosphoribosyl transferase domain containing 1


6472
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)


23512
SUZ12
suppressor of zeste 12 homolog (Drosophila)


586
BCAT1
branched chain aminotransferase 1, cytosolic


8836
GGH
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)


10383
TUBB2
tubulin, beta, 2


54101
RIPK4
receptor-interacting serine-threonine kinase 4


130271
PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain)




member 2


129401
NUP35
nucleoporin 35kDa


10128
LRPPRC
leucine-rich PPR-motif containing


51703
ACSL5
acyl-CoA synthetase long-chain family member 5


9448
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4


79017
C7orf24
chromosome 7 open reading frame 24


262
AMD1
adenosylmethionine decarboxylase 1


960
CD44
CD44 antigen (homing function and Indian blood group system)


81930
KIF18A
kinesin family member 18A


64116
SLC39A8
solute carrier family 39 (zinc transporter), member 8


26586
CKAP2
cytoskeleton associated protein 2


51144
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12


51002
CGI-121
CGI-121 protein


9126
CSPG6
chondroitin sulfate proteoglycan 6 (bamacan)


79154
MGC4172
short-chain dehydrogenase/reductase


11096
ADAMTS5
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin




type 1 motif, 5 (aggrecanase-2)


84803
MGC11324
hypothetical protein MGC11324


4082
MARCKS
myristoylated alanine-rich protein kinase C substrate


4086
SMAD1
SMAD, mothers against DPP homolog 1 (Drosophila)


9446
GSTO1
glutathione S-transferase omega 1


23636
NUP62
nucleoporin 62kDa


81839
VANGL1
vang-like 1 (van gogh, Drosophila)


3149
HMGB3
high-mobility group box 3


79023
NUP37
nucleoporin 37kDa


10606
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole 




succinocarboxamide synthetase


10492
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein


3320
HSPCA
heat shock 90kDa protein 1, alpha


6119
RPA3
replication protein A3, 14kDa


55352
HSA272196
hypothetical protein, clone 2746033


9759
HDAC4
histone deacetylase 4


5725
PTBP1
polypyrimidine tract binding protein 1


2119
ETV5
ets variant gene 5 (ets-related molecule)


10019
LNK
lymphocyte adaptor protein


9734
HDAC9
histone deacetylase 9


5885
RAD21
RAD21 homolog (S. pombe)


79930
DOK3
docking protein 3


22837
COBLL1
COBL-like 1


339448
LOC339448
hypothetical protein LOC339448


11051
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21


9735
KNTC1
kinetochore associated 1


4148
MATN3
matrilin 3


4200
ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial


26084
SGEF
Src homology 3 domain-containing guanine nucleotide exchange factor


27101
CACYBP
calcyclin binding protein


23012
STK38L
serine/threonine kinase 38 like


54566
EPB41L4B
erythrocyte membrane protein band 4.1 like 4B


6566
SLC16A1
solute carrier family 16 (monocarboxylic acid transporters), member 1


54947
FLJ20481
hypothetical protein FLJ20481


255488
IBRDC2
IBR domain containing 2


2289
FKBP5
FK506 binding protein 5


5036
PA2G4
proliferation-associated 2G4, 38kDa


4869
NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)


10384
BTN3A3
butyrophilin, subfamily 3, member A3


10785
WDR4
WD repeat domain 4


3099
HK2
hexokinase 2


56121
PCDHB15
protocadherin beta 15


10155
TRIM28
tripartite motif-containing 28


6340
SCNN1G
sodium channel, nonvoltage-gated 1, gamma


25804
LSM4
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)


3939
LDHA
lactate dehydrogenase A


57552
AADACL1
arylacetamide deacetylase-like 1


9184
BUB3
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)


657
BMPR1A
bone morphogenetic protein receptor, type IA


5631
PRPS1
phosphoribosyl pyrophosphate synthetase 1


204
AK2
adenylate kinase 2


55270
NUDT15
nudix (nucleoside diphosphate linked moiety X)-type motif 15


10265
IRX5
iroquois homeobox protein 5


4640
MYO1A
myosin IA


79180
EFHD2
EF hand domain family, member D2


4076
M11S1
membrane component, chromosome 11, surface marker 1


55276
PGM2
phosphoglucomutase 2


83857
ARG99
ARG99 protein


116448
OLIG1
oligodendrocyte transcription factor 1


5696
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional




protease 7)


1407
CRY1
cryptochrome 1 (photolyase-like)


11177
BAZ1A
bromodomain adjacent to zinc finger domain, 1A


51015
ISOC1
isochorismatase domain containing 1


1789
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta


22948
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)


158563
LOC158563
hypothetical protein LOC158563


89891
WDR34
WD repeat domain 34


119
ADD2
adducin 2 (beta)


5358
PLS3
plastin 3 (T isoform)


7086
TKT
transketolase (Wernicke-Korsakoff syndrome)


51174
TUBD1
tubulin, delta 1


23255
KIAA0802
KIAA0802


54149
C21orf91
chromosome 21 open reading frame 91


2271
FH
fumarate hydratase


55076
TMEM45A
transmembrane protein 45A


10436
C2F
C2f protein


8553
BHLHB2
basic helix-loop-helix domain containing, class B, 2


10409
BASP1
brain abundant, membrane attached signal protein 1


22856
CHSY1
carbohydrate (chondroitin) synthase 1


84451
KIAA1804
mixed lineage kinase 4


3150
HMGN1
high-mobility group nucleosome binding domain 1


961
CD47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)


79038
ZFYVE21
zinc finger, FYVE domain containing 21


7291
TWIST1
twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)




(Drosophila)


9738
CP110
CP110 protein


10625
IVNS1ABP
influenza virus NS1A binding protein


9368
SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1


3613
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2


8514
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2


4957
ODF2
outer dense fiber of sperm tails 2


4673
NAP1L1
nucleosome assembly protein 1-like 1


26018
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1


3033
HADHSC
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain


139886
LOC139886
hypothetical protein LOC139886


10360
NPM3
nucleophosmin/nucleoplasmin, 3


200894
ARL2L1
ADP-ribosylation factor-like 2-like 1


8364
HIST1H4C
histone 1, H4c


378708
APITD1
apoptosis-inducing, TAF9-like domain 1


169270
ZNF596
zinc finger protein 596


6917
TCEA1
transcription elongation factor A (SII), 1


7091
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)


3725
JUN
v-jun sarcoma virus 17 oncogene homolog (avian)


1736
DKC1
dyskeratosis congenita 1, dyskerin


8566
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase


51176
LEF1
lymphoid enhancer-binding factor 1


87
ACTN1
actinin, alpha 1


10838
ZNF275
zinc finger protein 275


54517
FLJ20485
hypothetical protein FLJ20485


5150
PDE7A
phosphodiesterase 7A


384
ARG2
arginase, type II


27316
RBMX
RNA binding motif protein, X-linked


389206
CCDC4
coiled-coil domain containing 4


51312
SLC25A37
solute carrier family 25, member 37


9112
MTA1
metastasis associated 1


6711
SPTBN1
spectrin, beta, non-erythrocytic 1


10129
13CDNA73
hypothetical protein CG003


80014
BOMB
BH3-only member B protein


27131
SNX5
sorting nexin 5


23089
PEG10
paternally expressed 10


5270
SERPINE2
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator




inhibitor type 1), member 2


6764
ST5
suppression of tumorigenicity 5


7791
ZYX
zyxin


22995
Cep152
KIAA0912 protein


4137
MAPT
microtubule-associated protein tau


5411
PNN
pinin, desmosome associated protein


3087
HHEX
hematopoietically expressed homeobox


23171
GPD1L
glycerol-3-phosphate dehydrogenase 1-like


56905
DKFZP434H132
DKFZP434H132 protein


3189
HNRPH3
heterogeneous nuclear ribonucleoprotein H3 (2H9)


9099
USP2
ubiquitin specific protease 2


10098
TSPAN5
tetraspanin 5


401505
C9orf105
chromosome 9 open reading frame 105


51444
RNF138
ring finger protein 138


11118
BTN3A2
butyrophilin, subfamily 3, member A2


8089
YEATS4
YEATS domain containing 4


84108
PCGF6
polycomb group ring finger 6


7514
XPO1
exportin 1 (CRM1 homolog, yeast)


9818
NUPL1
nucleoporin like 1


10923
PC4
activated RNA polymerase II transcription cofactor 4


6526
SLC5A3
solute carrier family 5 (inositol transporters), member 3


26010
DNAPTP6
DNA polymerase-transactivated protein 6


5307
PITX1
paired-like homeodomain transcription factor 1


2643
GCH1
GTP cyclohydrolase 1 (dopa-responsive dystonia)


1503
CTPS
CTP synthase


5777
PTPN6
protein tyrosine phosphatase, non-receptor type 6


23122
CLASP2
cytoplasmic linker associated protein 2


5588
PRKCQ
protein kinase C, theta


64770
CCDC14
coiled-coil domain containing 14


6426
SFRS1
splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)


81831
NETO2
neuropilin (NRP) and tolloid (TLL)-like 2


56888
KCMF1
potassium channel modulatory factor 1


9221
NOLC1
nucleolar and coiled-body phosphoprotein 1


79366
NSBP1
nucleosomal binding protein 1


51729
WBP11
WW domain binding protein 11


84444
DOTI L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)


80218
MAK3
Mak3 homolog (S. cerevisiae)


84319
MGC4308
hypothetical protein MGC4308


112479
MGC16943
similar to RIKEN cDNA 4933424N09 gene


64396
GMCL1L
germ cell-less homolog 1 (Drosophila)-like


5905
RANGAP1
Ran GTPase activating protein 1


2177
FANCD2
Fanconi anemia, complementation group D2


55632
KIAA1333
KIAA1333


3695
ITGB7
integrin, beta 7


9793
CKAP5
cytoskeleton associated protein 5


5318
PKP2
plakophilin 2


6652
SORD
sorbitol dehydrogenase


80709
AKNA
AT-hook transcription factor


55120
FANCL
Fanconi anemia, complementation group L


92667
C20orf72
chromosome 20 open reading frame 72


3654
IRAK1
interleukin-1 receptor-associated kinase 1


55975
KLHL7
kelch-like 7 (Drosophila)


6397
SEC14L1
SEC14-like 1 (S. cerevisiae)


29117
BRD7
bromodomain containing 7


6732
SRPK1
SFRS protein kinase 1


401081
FLJ22763
hypothetical gene supported by AK026416


8520
HAT1
histone acetyltransferase 1


3119
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1


7283
TUBG1
tubulin, gamma 1


4809
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)


2778
GNAS
GNAS complex locus


5359
PLSCR1
phospholipid scramblase 1


196294
FLJ25059
hypothetical protein FLJ25059


3181
HNRPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1


1794
DOCK2
dedicator of cytokinesis 2


55148
C14orf130
chromosome 14 open reading frame 130


25924
MYRIP
myosin VIIA and Rab interacting protein


7533
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta




polypeptide


64968
MRPS6
mitochondrial ribosomal protein S6


4830
NME1
non-metastatic cells 1, protein (NM23A) expressed in


165055
FLJ32745
hypothetical protein FLJ32745


151827
LRRC34
leucine rich repeat containing 34


93081
LOC93081
hypothetical protein BC015148


196527
TMEM16F
transmembrane protein 16F


1827
DSCR1
Down syndrome critical region gene 1


203562
TMEM31
transmembrane protein 31


11335
CBX3
chromobox homolog 3 (HP1 gamma homolog, Drosophila)


3662
IRF4
interferon regulatory factor 4


8624
DSCR2
Down syndrome critical region gene 2


4092
SMAD7
SMAD, mothers against DPP homolog 7 (Drosophila)


6934
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)


26112
DKFZP434C171
DKFZP434C171 protein


3329
HSPD1
heat shock 60kDa protein 1 (chaperonin)


5577
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta


3202
HOXA5
homeo box AS


79442
LRRC2
leucine rich repeat containing 2


9631
NUP155
nucleoporin 155kDa


55366
LGR4
leucine-rich repeat-containing G protein-coupled receptor 4


23350
SR140
U2-associated SR140 protein


6434
SFRS10
splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)


7975
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)


3187
HNRPH1
heterogeneous nuclear ribonucleoprotein H1 (H)


94239
H2AFV
H2A histone family, member V


54913
RPP25
ribonuclease P 25kDa subunit


9521
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1


5471
PPAT
phosphoribosyl pyrophosphate amidotransferase


340252
ZNF680
zinc finger protein 680


1021
CDK6
cyclin-dependent kinase 6


10560
SLC19A2
solute carrier family 19 (thiamine transporter), member 2


4201
MEA1
male-enhanced antigen 1


440145
LOC440145
similar to RIKEN cDNA 2410129H14


3843
RANBP5
RAN binding protein 5


3298
HSF2
heat shock transcription factor 2


387914
TMEM46
transmembrane protein 46


27347
STK39
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)


6256
RXRA
retinoid X receptor, alpha


6637
SNRPG
small nuclear ribonucleoprotein polypeptide G


22800
RRAS2
related RAS viral (r-ras) oncogene homolog 2


91694
FLJ23749
hypothetical protein FLJ23749


22823
MTF2
metal response element binding transcription factor 2


51184
MGC14560
protein x 0004


10856
RUVBL2
RuvB-like 2 (E. coli)


7188
TRAF5
TNF receptor-associated factor 5


5272
SERPINB9
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9


11169
WDHD1
WD repeat and HMG-box DNA binding protein 1


5606
MAP2K3
mitogen-activated protein kinase kinase 3


4783
NFIL3
nuclear factor, interleukin 3 regulated


51691
LSM8
LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)


1528
CYB5
cytochrome b-5


79899
FLJ14213
hypothetical protein FLJ14213


7334
UBE2N
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)


2730
GCLM
glutamate-cysteine ligase, modifier subunit


23157
SEPT6
septin 6


56155
TEX14
testis expressed sequence 14


23658
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)


1400
CRMP1
collapsin response mediator protein 1


5684
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3


6713
SQLE
squalene epoxidase


84955
NUDCD1
NudC domain containing 1


64318
C10or1117 
chromosome 10 open reading frame 117


10196
HRMT1L3
HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)


29841
GRHL1
grainyhead-like 1 (Drosophila)


10055
SAE1
SUMO-1 activating enzyme subunit 1


9214
FAIM3
Fas apoptotic inhibitory molecule 3


57406
ABHD6
abhydrolase domain containing 6


25914
RTTN
rotatin


23244
SCC-112
SCC-112 protein


3183
HNRPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)


55117
SLC6A15
solute carrier family 6, member 15


6950
TCP1
t-complex 1


4660
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B


134429
STARD4
START domain containing 4, sterol regulated


157503
LOC157503
hypothetical protein LOC157503


253832
ZDHHC20
zinc finger, DHHC-type containing 20


375061
MGC15887
hypothetical gene supported by BC009447


84986
ARHGAP19
Rho GTPase activating protein 19


8407
TAGLN2
transgelin 2


285704
RGMB
RGM domain family, member B


5050
PAFAH1B3
platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa


4208
MEF2C
MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer




factor 2C)


55614
C20orf23
chromosome 20 open reading frame 23


388796
LOC388796
hypothetical LOC388796


85463
ZC3H12C
zinc finger CCCH-type containing 12C


51465
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)


9994
CASP8AP2
CASP8 associated protein 2


26135
PAI-RBP1
PAI-1 mRNA binding protein


5634
PRPS2
phosphoribosyl pyrophosphate synthetase 2


286319
TUSC1
tumor suppressor candidate 1


6470
SHMT1
serine hydroxymethyltransferase 1 (soluble)


9397
NMT2
N-myristoyltransferase 2


10762
NUP50
nucleoporin 50kDa


201161
PRR6
proline rich 6


5019
OXCT1
3-oxoacid CoA transferase 1


159
ADSS
adenylosuccinate synthase


23587
DERP6
S-phase 2 protein


10151
HNRPA3P1
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1


8564
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)


1349
COX7B
cytochrome c oxidase subunit VIIb


283824
LOC283824
hypothetical protein LOC283824


1123
CHN1
chimerin (chimaerin) 1


57522
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1


253782
LASS6
LAG1 longevity assurance homolog 6 (S. cerevisiae)


57685
KIAA1573
KIAA1573 protein


79695
GALNT12
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl-




transferase 12 (GaINAc-T12)


90861
C16orf34
chromosome 16 open reading frame 34


26207
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1


1164
CKS2
CDC28 protein kinase regulatory subunit 2


396
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha


57530
CGN
cingulin


1633
DCK
deoxycytidine kinase


9208
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1


6453
ITSN1
intersectin 1 (SH3 domain protein)


24147
FJX1
four jointed box 1 (Drosophila)


9882
TBC1D4
TBC1 domain family, member 4


169200
DKFZp762C1112
hypothetical protein DKFZp762C1112


9331
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6


55183
RIF1
RAP1 interacting factor homolog (yeast)


221362
LOC221362
hypothetical protein LOC221362


8458
TTF2
transcription termination factor, RNA polymerase II


1047
CLGN
calmegin


56919
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33


93949
CXorf10
chromosome X open reading frame 10


5569
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha


6891
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)


1960
EGR3
early growth response 3


11252
PACSIN2
protein kinase C and casein kinase substrate in neurons 2


51762
RAB8B
RAB8B, member RAS oncogene family


81575
DKFZP434F0318
hypothetical protein DKFZp434F0318


56906
THAP10
THAP domain containing 10


55110
FLJ10292
mago-nashi homolog


5267
SERPINA4
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,




antitrypsin), member 4


1844
DUSP2
dual specificity phosphatase 2


9612
NCOR2
nuclear receptor co-repressor 2


3276
HRMT1L2
HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)


257415
MGC40405
hypothetical protein MGC40405


79720
FLJ12750
hypothetical protein FLJ12750


160897
ITR
intimal thickness-related receptor


4522
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetra-




hydrofolate cyclohydrolase, formyltetrahydrofolate synthetase


4668
NAGA
N-acetylgalactosaminidase, alpha-


84890
C10orf22
chromosome 10 open reading frame 22


5198
PFAS
phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)


55544
RNPC1
RNA-binding region (RNP1, RRM) containing 1


2618
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide




synthetase, phosphoribosylaminoimidazole synthetase


9261
MAPKAPK2
mitogen-activated protein kinase-activated protein kinase 2


285761
DCBLD1
discoidin, CUB and LCCL domain containing 1


23225
NUP210
nucleoporin 210kDa


9792
SERTAD2
SERTA domain containing 2


56938
ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2


23254
KIAA1026
kazrin


4628
MYH10
myosin, heavy polypeptide 10, non-muscle


23176
SEPT8
septin 8


1432
MAPK14
mitogen-activated protein kinase 14


84549
RBM13
RNA binding motif protein 13


84133
ZNRF3
zinc and ring finger 3


6502
SKP2
S-phase kinase-associated protein 2 (p45)


59274
MESDC1
mesoderm development candidate 1


51496
HSPC129
hypothetical protein HSPC129


55151
TMEM38B
transmembrane protein 38B


57609
KIAA1463
KIAA1463 protein


1039
CDR2
cerebellar degeneration-related protein 2, 62kDa


143098
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)


130589
GALM
galactose mutarotase (aldose 1-epimerase) lymphocyte cytosolic


3937
LCP2
protein 2 (SH2 domain containing leukocyte protein of 76kDa)


5420
PODXL
podocalyxin-like


6509
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4


64397
ZFP106
zinc finger protein 106 homolog (mouse)


4860
NP
nucleoside phosphorylase


3535
IGL@
immunoglobulin lambda locus


1396
CRIP1
cysteine-rich protein 1 (intestinal)


1660
DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9


4291
MLF1
myeloid leukemia factor 1


26973
CHORDC1
cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1


81037
CRR9
cisplatin resistance related protein CRR9p


10574
CCT7
chaperonin containing TCP1, subunit 7 (eta)


79892
C10orf119
chromosome 10 open reading frame 119


9972
NUP153
nucleoporin 153kDa


10459
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)


483
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide


7552
ZNF6
zinc finger protein 6 (CMPX1)


8165
AKAP1
A kinase (PRKA) anchor protein 1


29097
CNIH4
cornichon homolog 4 (Drosophila)


11198
SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)


2184
FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)


7037
TFRC
transferrin receptor (p90, CD71)


6461
SHB
Src homology 2 domain containing adaptor protein B


509
ATP5C1
ATP synthase, H+ transporting, mitochondrial F1complex, gamma polypeptide 1


5591
PRKDC
protein kinase, DNA-activated, catalytic polypeptide


10682
EBP
emopamil binding protein (sterol isomerase)


9188
DDX21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21


3837
KPNB1
karyopherin (importin) beta 1


3191
HNRPL
heterogeneous nuclear ribonucleoprotein L


10236
HNRPR
heterogeneous nuclear ribonucleoprotein R


6907
TBL1X
transducin (beta)-like 1X-linked


56172
ANKH
ankylosis, progressive homolog (mouse)


23367
LARP1
La ribonucleoprotein domain family, member 1


5778
PTPN7
protein tyrosine phosphatase, non-receptor type 7


100
ADA
adenosine deaminase


2821
GPI
glucose phosphate isomerase


9697
TRAM2
translocation associated membrane protein 2


54927
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3


58478
MASA
E-1 enzyme


6322
SCML1
sex comb on midleg-like 1 (Drosophila)


292
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator),




member 5


10857
PGRMC1
progesterone receptor membrane component 1


55342
STRBP
spermatid perinuclear RNA binding protein


7150
TOP1
topoisomerase (DNA) I


874
CBR3
carbonyl reductase 3


51096
WDR50
WD repeat domain 50


253558
LYCAT
lysocardiolipin acyltransferase


79053
ALG8
asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)


84300
C6orf125
chromosome 6 open reading frame 125


8975
USP13
ubiquitin specific protease 13 (isopeptidase T-3)


220988
HNRPA3
heterogeneous nuclear ribonucleoprotein A3


5315
PKM2
pyruvate kinase, muscle


7411
VBP1
von Hippel-Lindau binding protein 1


1665
DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15


10963
STIP1
stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)


253461
ZBTB38
zinc finger and BTB domain containing 38


29080
HSPC128
HSPC128 protein


84275
MGC4399
mitochondrial carrier protein


1622
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme




A binding protein)


4953
ODC1
ornithine decarboxylase 1


2029
ENSA
endosulfine alpha


6404
SELPLG
selectin P ligand


81034
MFTC
mitochondrial folate transporter/carrier


81542
TXNDC
thioredoxin domain containing


25816
TNFAIP8
tumor necrosis factor, alpha-induced protein 8


51582
AZIN1
antizyme inhibitor 1


27436
EML4
echinoderm microtubule associated protein like 4


55720
FLJ10534
hypothetical protein FLJ10534


7295
TXN
thioredoxin


10539
TXNL2
thioredoxin-like 2


86
ACTL6A
actin-like 6A


6731
SRP72
signal recognition particle 72kDa


23314
SATB2
SATB family member 2


2273
FHL1
four and a half LIM domains 1


3422
IDI1
isopentenyl-diphosphate delta isomerase


10935
PRDX3
peroxiredoxin 3


2958
GTF2A2
general transcription factor IIA, 2, 12kDa


4144
MAT2A
methionine adenosyltransferase II, alpha


1964
EIF1AX
eukaryotic translation initiation factor 1A, X-linked


60
ACTB
actin, beta


11191
PTENP1
phosphatase and tensin homolog (mutated in multiple advanced cancers 1),




pseudogene 1


90843
TCEAL8
transcription elongation factor A (SII)-like 8


57181
SLC39A10
solute carrier family 39 (zinc transporter), member 10


11147
HHLA3
HERV-H LTR-associating 3


10553
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa


3338
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4


84888
SPPL2A
signal peptide peptidase-like 2A


1955
EGFL5
EGF-like-domain, multiple 5


329
BIRC2
baculoviral IAP repeat-containing 2


29927
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)


9559
VPS26
vacuolar protein sorting 26 (yeast)


23270
TSPYL4
TSPY-like 4


6309
SC5DL
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like


10397
NDRG1
N-myc downstream regulated gene 1


27032
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1


11112
HIBADH
3-hydroxyisobutyrate dehydrogenase


1476
CSTB
cystatin B (stefin B)


9620
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)


56650
C3orf4
chromosome 3 open reading frame 4


29922
NME7
non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)


8887
TAXI BP1
Tax1 (human T-cell leukemia virus type I) binding protein 1


5445
PON2
paraoxonase 2


81889
FAHD1
fumarylacetoacetate hydrolase domain containing 1


694
BTG1
B-cell translocation gene 1, anti-proliferative


29058
C20orf30
chromosome 20 open reading frame 30


2752
GLUL
glutamate-ammonia ligase (glutamine synthase)


79717
FLJ11838
hypothetical protein FLJ11838


170622
COMMD6
COMM domain containing 6


5792
PTPRF
protein tyrosine phosphatase, receptor type, F


64393
WIG1
p53 target zinc finger protein


549
AUH
AU RNA binding protein/enoyl-Coenzyme A hydratase


51282
SCAND1
SCAN domain containing 1


79027
ZNF655
zinc finger protein 655


6451
SH3BGRL
SH3 domain binding glutamic acid-rich protein like


1347
COX7A2
cytochrome c oxidase subunit Vlla polypeptide 2 (liver)


550643
L00550643
hypothetical protein L00550643


6926
TBX3
T-box 3 (ulnar mammary syndrome)


51614
SDBCAG84
serologically defined breast cancer antigen 84


9520
NPEPPS
aminopeptidase puromycin sensitive


51065
RPS27L
ribosomal protein S27-like


10116
FEM1B
fem-1 homolog b (C. elegans)


10521
DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17


81557
MAGED4
melanoma antigen family D, 4


10133
OPTN
optineurin


54504
CPVL
carboxypeptidase, vitellogenic-like


64062
C13orf10
chromosome 13 open reading frame 10


401115
LOC401115
hypothetical gene supported by BC038466; BC062790


6892
TAPBP
TAP binding protein (tapasin)


8087
FXR1
fragile X mental retardation, autosomal homolog 1


7905
C5orf18
chromosome 5 open reading frame 18


3916
LAMP1
lysosomal-associated membrane protein 1


22982
KIAA0934
KIAA0934


55615
PRR5
proline rich protein 5


5651
PRSS7
protease, serine, 7 (enterokinase)


10449
ACAA2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme




A thiolase)


8934
RAB7L1
RAB7, member RAS oncogene family-like 1


10114
HIPK3
homeodomain interacting protein kinase 3


57560
WDR56
WD repeat domain 56


51205
ACP6
acid phosphatase 6, lysophosphatidic


6238
RRBP1
ribosome binding protein 1 homolog 180kDa (dog)


151011
SEPT10
septin 10


22920
KIFAP3
kinesin-associated protein 3


3958
LGALS3
lectin, galactoside-binding, soluble, 3 (galectin 3)


84186
ZCCHC7
zinc finger, CCHC domain containing 7


9452
ITM2A
integral membrane protein 2A


10159
ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2


23641
LDOC1
leucine zipper, down-regulated in cancer 1


967
CD63
CD63 antigen (melanoma 1 antigen)


2517
FUCA1
fucosidase, alpha-L- 1, tissue


23219
FBXO28
F-box protein 28


79982
DNAJB14
DnaJ (Hsp40) homolog, subfamily B, member 14


7328
UBE2H
ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)


23355
KIAA0804
KIAA0804


257103
C21orf86
chromosome 21 open reading frame 86


6307
SC4MOL
sterol-C4-methyl oxidase-like


23376
KIAA0776
KIAA0776


57700
KIAA1600
KIAA1600


85461
TANG
TPR domain, ankyrin-repeat and coiled-coil-containing


4247
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase


3383
ICAM1
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor


493812
HCG11
HLA complex group 11


5921
RASA1
RAS p21 protein activator (GTPase activating protein) 1


23563
CHST5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5


51100
SH3GLB1
SH3-domain GRB2-like endophilin B1


339988
LOC339988
hypothetical protein LOC339988


79080
MGC2574
hypothetical protein MGC2574


55761
TTC17
tetratricopeptide repeat domain 17


144871
LOC144871
hypothetical protein LOC144871


4194
MDM4
Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)


51030
FAM18B
family with sequence similarity 18, member B


1650
DDOST
dolichyl-diphosphooligosaccharide-protein glycosyltransferase


147463
ANKRD29
ankyrin repeat domain 29


3757
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2


116442
RAB39B
RAB39B, member RAS oncogene family


10972
TMP21
transmembrane trafficking protein


57798
GATAD1
GATA zinc finger domain containing 1


1314
COPA
coatomer protein complex, subunit alpha


2581
GALC
galactosylceramidase (Krabbe disease)


91452
ACBD5
acyl-Coenzyme A binding domain containing 5


8879
SGPL1
sphingosine-1-phosphate lyase 1


4897
NRCAM
neuronal cell adhesion molecule


23209
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1


440270
LOC440270
golgin-67


5034
P4HB
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase),




beta polypeptide (protein disulfide isomerase-associated 1)


148646
FLJ32096
hypothetical protein FLJ32096


399917
LOC399917
similar to polymerase


7096
TLR1
toll-like receptor 1


80853
KIAA1718
KIAA1718 protein


378938
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


1266
CNN3
calponin 3, acidic


58486
LOC58486
transposon-derived Buster1 transposase-like protein gene


1040
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1


9895
KIAA0329
KIAA0329


1509
CTSD
cathepsin D (lysosomal aspartyl protease)


26115
DKFZP564D166
putative ankyrin-repeat containing protein


57162
PELI1
pellino homolog 1 (Drosophila)


57599
WDR48
WD repeat domain 48


285464
FLJ34443
hypothetical protein FLJ34443


55857
C20orf19
chromosome 20 open reading frame 19


339456
LOC339456
hypothetical protein LOC339456


51569
UFM1
ubiquitin-fold modifier 1


582
BBS1
Bardet-Biedl syndrome 1


4637
MYL6
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle


1186
CLCN7
chloride channel 7


3490
IGFBP7
insulin-like growth factor binding protein 7


5095
PCCA
propionyl Coenzyme A carboxylase, alpha polypeptide


10966
RAB40B
RAB40B, member RAS oncogene family


285362
SUMF1
sulfatase modifying factor 1


56122
PCDHB14
protocadherin beta 14


57534
MIB1
mindbomb homolog 1 (Drosophila)


56951
C5orf15
chromosome 5 open reading frame 15


113177
C19orf36
chromosome 19 open reading frame 36


10379
ISGF3G
interferon-stimulated transcription factor 3, gamma 48kDa


64224
FLJ22313
hypothetical protein FLJ22313


65084
FLJ22104
hypothetical protein FLJ22104


10537
UBD
ubiquitin D


8548
BLZF1
basic leucine zipper nuclear factor 1 (JEM-1)


284214
LOC284214
hypothetical protein LOC284214


8334
HIST1H2AC
histone 1, H2ac


80210
FLJ12584
melanoma/melanocyte specific protein KU-MEL-1


1182
CLCN3
chloride channel 3


26751
SH3YL1
SH3 domain containing, Ysc84-like 1 (S. cerevisiae)


114327
EFHC1
EF-hand domain (C-terminal) containing 1


7351
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)


10724
MGEA5
meningioma expressed antigen 5 (hyaluronidase)


9652
KIAA0372
KIAA0372


200958
MUC20
mucin 20


161527
LOC161527
hypothetical protein LOC161527


10314
LANCL1
LanC lantibiotic synthetase component C-like 1 (bacterial)


2923
PDIA3
protein disulfide isomerase family A, member 3


84247
LDOC1L
leucine zipper, down-regulated in cancer 1-like


3006
HIST1H1C
histone 1, H1c


9562
MINPP1
multiple inositol polyphosphate histidine phosphatase, 1


115024
MGC20781
hypothetical protein MGC20781


65982
FLJ12895
hypothetical protein FLJ12895


5268
SERPINB5
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5


94240
EPSTI1
epithelial stromal interaction 1 (breast)


2621
GAS6
growth arrest-specific 6


401024
FLJ44048
FLJ44048 protein


57142
RTN4
reticulon 4


50854
C6orf48
chromosome 6 open reading frame 48


317649
EIF4E3
eukaryotic translation initiation factor 4E member 3


4179
MCP
membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)


54884
RetSat
all-trans-13,14-dihydroretinol saturase


10154
PLXNC1
plexin C1


2630
GBAP
glucosidase, beta; acid, pseudogene


7077
TIMP2
tissue inhibitor of metalloproteinase 2


23741
CRI1
CREBBP/EP300 inhibitor 1


949
SCARB1
scavenger receptor class B, member 1


1519
CTSO
cathepsin O


51136
LOC51136
PTD016 protein


3428
IFI16
interferon, gamma-inducible protein 16


9516
LITAF
lipopolysaccharide-induced TNF factor


3123
HLA-DRB1
major histocompatibility complex, class II, DR beta 1


1389
CREBL2
cAMP responsive element binding protein-like 2


5027
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7


6782
STCH
stress 70 protein chaperone, microsome-associated, 60kDa


5645
PRSS2
protease, serine, 2 (trypsin 2)


84282
RNF135
ring finger protein 135


9852
EPM2AIP1
EPM2A (laforin) interacting protein 1


84333
PCGF5
polycomb group ring finger 5


23475
QPRT
quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase




(carboxylating))


11142
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma


54832
VPS13C
vacuolar protein sorting 13C (yeast)


1486
CTBS
chitobiase, di-N-acetyl-


4601
MXI1
MAX interactor 1


1365
CLDN3
claudin 3


81622
UNC93B1
unc-93 homolog B1 (C. elegans)


54664
FLJ11273
hypothetical protein FLJ11273


9993
DGCR2
DiGeorge syndrome critical region gene 2


57179
KIAA1191
KIAA1191 protein


55958
KLHL9
kelch-like 9 (Drosophila)


81671
TMEM49
transmembrane protein 49


9666
DZIP3
zinc finger DAZ interacting protein 3


10509
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and




short cytoplasmic domain, (semaphorin) 4B


3782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily




N, member 3


4644
MYO5A
myosin VA (heavy polypeptide 12, myoxin)


55179
FAIM
Fas apoptotic inhibitory molecule


9687
GREB1
GREB1 protein


25861
DFNB31
deafness, autosomal recessive 31


9197
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1


10549
PRDX4
peroxiredoxin 4


27090
ST6GALNAC4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide




alpha-2,6-sialyltransferase 4


3988
LIPA
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)


10577
NPC2
Niemann-Pick disease, type C2


441951
HSUP1
similar to RPE-spondin


26275
HIBCH
3-hydroxyisobutyryl-Coenzyme A hydrolase


401397
LOC401397
hypothetical LOC401397


81555
YIPF5
Yip1 domain family, member 5


19
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1


2896
GRN
granulin


1312
COMT
catechol-O-methyltransferase


127018
LYPLAL1
lysophospholipase-like 1


5911
RAP2A
RAP2A, member of RAS oncogene family


3017
HIST1H2BD
histone 1, H2bd


9139
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2


50848
F11R
F11 receptor


3728
JUP
junction plakoglobin


8615
VDP
vesicle docking protein p115


79090
MGC2650
hypothetical protein MGC2650


51303
FKBP11
FK506 binding protein 11, 19kDa


64747
MFSD1
major facilitator superfamily domain containing 1


23471
TRAM1
translocation associated membrane protein 1


1832
DSP
desmoplakin


125144
MGC40157
hypothetical protein MGC40157


10150
MBNL2
muscleblind-like 2 (Drosophila)


3082
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)


7750
ZNF198
zinc finger protein 198


2908
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


25758
G2
G2 protein


10653
SPINT2
serine protease inhibitor, Kunitz type, 2


116151
C20orf108
chromosome 20 open reading frame 108


8933
CXX1
CAAX box 1


475
ATOX1
ATX1 antioxidant protein 1 homolog (yeast)


23406
COTL1
coactosin-like 1 (Dictyostelium)


57561
ARRDC3
arrestin domain containing 3


55205
ZNF532
zinc finger protein 532


25796
PGLS
6-phosphogluconolactonase


283846
DKFZp547E087
P1-3-kinase-related kinase SMG-1-like


57185
DJ462023.2
hypothetical protein dJ462O23.2


54431
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10


5800
PTPRO
protein tyrosine phosphatase, receptor type, O


1465
CSRP1
cysteine and glycine-rich protein 1


950
SCARB2
scavenger receptor class B, member 2


51019
CGI-116
CGI-116 protein


5476
PPGB
protective protein for beta-galactosidase (galactosialidosis)


54145
H2BFS
H2B histone family, member S


65981
C1QDC1
C1q domain containing 1


81502
HM13
histocompatibility (minor) 13


3572
IL6ST
interleukin 6 signal transducer (gp130, oncostatin M receptor)


1299
COL9A3
collagen, type IX, alpha 3


1386
ATF2
activating transcription factor 2


4134
MAP4
microtubule-associated protein 4


3981
LIG4
ligase IV, DNA, ATP-dependent


57714
KIAA1618
KIAA1618


80315
CPEB4
cytoplasmic polyadenylation element binding protein 4


107
ADCY1
adenylate cyclase 1 (brain)


8804
CREG1
cellular repressor of E1A-stimulated genes 1


84181
CHD6
chromodomain helicase DNA binding protein 6


22871
NLGN1
neuroligin 1


659
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)


79158
MGC4170
MGC4170 protein


112399
EGLN3
egl nine homolog 3 (C. elegans)


10550
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5


55573
H41
hypothetical protein H41


51706
NQO3A2
NAD(P)H:quinone oxidoreductase type 3, polypeptide A2


79738
FLJ23560
hypothetical protein FLJ23560


6672
SP100
nuclear antigen Sp100


145173
B3GTL
beta 3-glycosyltransferase-like


3275
HRMT1L1
HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)


54059
C21orf57
chromosome 21 open reading frame 57


571
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1


6990
TCTE1L
t-complex-associated-testis-expressed 1-like


9341
VAMP3
vesicle-associated membrane protein 3 (cellubrevin)


2180
ACSL1
acyl-CoA synthetase long-chain family member 1


2799
GNS
glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)


9236
CCPG1
cell cycle progression 1


51111
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)


598
BCL2L1
BCL2-like 1


57674
C17orf27
chromosome 17 open reading frame 27


1488
CTBP2
C-terminal binding protein 2


80267
C1orf22
chromosome 1 open reading frame 22


90701
SEC11L3
SEC11-like 3 (S. cerevisiae)


84218
TBC1D3
TBC1 domain family, member 3


7844
RNF103
ring finger protein 103


8440
NCK2
NCK adaptor protein 2


25934
NIPSNAP3A
nipsnap homolog 3A (C. elegans)


3897
L1CAM
L1 cell adhesion molecule


114915
TIGA1
TIGA1


754
PTTG1IP
pituitary tumor-transforming 1 interacting protein


10525
HYOU1
hypoxia up-regulated 1


966
CD59
CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16,




EJ30, EL32 and G344)


25976
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase


3714
JAG2
jagged 2


8780
RIOK3
RIO kinase 3 (yeast)


55827
IQWD1
IQ motif and WD repeats 1


55830
GLT8D1
glycosyltransferase 8 domain containing 1


4779
NFE2L1
nuclear factor (erythroid-derived 2)-like 1


7286
TUFT1
tuftelin 1


1028
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)


60492
MDS025
hypothetical protein MDS025


27319
BHLHB5
basic helix-loop-helix domain containing, class B, 5


1958
EGR1
early growth response 1


89796
NAV1
neuron navigator 1


9240
PNMA1
paraneoplastic antigen MA1


6773
STAT2
signal transducer and activator of transcription 2, 113kDa


7494
XBP1
X-box binding protein 1


11057
ABHD2
abhydrolase domain containing 2


9451
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3


8878
SQSTM1
sequestosome 1


302
ANXA2
annexin A2


2590
GALNT2
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-




acetylgalactosaminyltransferase 2 (GaINAc-T2)


1200
TPP1
tripeptidyl peptidase I


5973
RENBP
renin binding protein


7259
TSPYL1
TSPY-like 1


112770
C1orf85
chromosome 1 open reading frame 85


93953
ACRC
acidic repeat containing


90634
CG018
hypothetical gene CG018


1030
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)


158158
RASEF
RAS and EF hand domain containing


2824
GPM6B
glycoprotein M6B


9706
ULK2
unc-51-like kinase 2 (C. elegans)


92370
ACPL2
acid phosphatase-like 2


1203
CLN5
ceroid-lipofuscinosis, neuronal 5


8337
HIST2H2AA
histone 2, H2aa


3998
LMAN1
lectin, mannose-binding, 1


56675
NRIP3
nuclear receptor interacting protein 3


4864
NPC1
Niemann-Pick disease, type Cl


3358
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C


304
ANXA2P2
annexin A2 pseudogene 2


81790
RNF170
ring finger protein 170


2537
G1P3
interferon, alpha-inducible protein (clone IFI-6-16)


55251
C20orf36
chromosome 20 open reading frame 36


27344
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor


10057
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5


81031
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10


467
ATF3
activating transcription factor 3


94103
ORMDL3
ORM1-like 3 (S. cerevisiae)


375593
TRIM50B
tripartite motif-containing 50B


23015
GM88
88-kDa golgi protein


55818
JMJD1A
jumonji domain containing 1A


5274
SERPINI1
serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1


23336
DMN
desmuslin


255631
COL24A1
collagen, type XXIV, alpha 1


3995
FADS3
fatty acid desaturase 3


5797
PTPRM
protein tyrosine phosphatase, receptor type, M


55876
GSDML
gasdermin-like


999
CDH1
cadherin 1, type 1, E-cadherin (epithelial)


84897
TBRG1
transforming growth factor beta regulator 1


51363
GALNAC4S-6ST
B cell RAG associated protein


9961
MVP
major vault protein


2982
GUCY1A3
guanylate cyclase 1, soluble, alpha 3


706
BZRP
benzodiazapine receptor (peripheral)


144203
OVOS2
ovostatin 2


8516
ITGA8
integrin, alpha 8


2037
EPB41L2
erythrocyte membrane protein band 4.1-like 2


1524
CX3CR1
chemokine (C-X3-C motif) receptor 1


222166
Ells1
hypothetical protein Ells1


339803
LOC339803
hypothetical protein LOC339803


5360
PLTP
phospholipid transfer protein


1612
DAPK1
death-associated protein kinase 1


90161
HS6ST2
heparan sulfate 6-O-sulfotransferase 2


115701
ALPK2
alpha-kinase 2


50640
IPLA2(GAMMA)
intracellular membrane-associated calcium-independent phospholipase A2 gamma


8473
OGT
O-linked N-acetylglucosamine (GIcNAc) transferase (UDP-N-acetylglucosamine:




polypeptide-N-acetylglucosaminyl transferase)


252839
TMEM9
transmembrane protein 9


150759
LOC150759
hypothetical protein LOC150759


401152
LOC401152
HCV F-transactivated protein 1


64065
PERP
PERP, TP53 apoptosis effector


114793
FMNL2
formin-like 2


477
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide


59338
PLEKHAl
pleckstrin homology domain containing, family A (phosphoinositide binding




specific) member 1


3727
JUND
jun D proto-oncogene


85236
HIST1H2BK
histone 1, H2bk


6513
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1


155038
GIMAP8
GTPase, IMAP family member 8


3055
HCK
hemopoietic cell kinase


6542
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2


8996
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)


9728
KIAA0256
KIAA0256 gene product


51237
PACAP
proapoptotic caspase adaptor protein


8987
GENX-3414
genethonin 1


132720
FLJ39370
hypothetical protein FLJ39370


1601
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)


54741
LEPROT
leptin receptor overlapping transcript


81631
MAP1LC3B
microtubule-associated protein 1 light chain 3 beta


9473
C1orf38
chromosome 1 open reading frame 38


94241
TP53INP1
tumor protein p53 inducible nuclear protein 1


5816
PVALB
parvalbumin


115294
LOC115294
similar to hypothetical protein FLJ10883


23461
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5


10370
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2


9604
RNF14
ring finger protein 14


387263
C6orf120
chromosome 6 open reading frame 120


9120
SLC16A6
solute carrier family 16 (monocarboxylic acid transporters), member 6


3915
LAMC1
laminin, gamma 1 (formerly LAMB2)


23092
ARHGAP26
Rho GTPase activating protein 26


64778
FNDC3B
fibronectin type III domain containing 3B


10140
TOB1
transducer of ERBB2, 1


23208
SYT11
synaptotag min XI


57730
KIAA1641
KIAA1641


120196
MGC34830
hypothetical protein MGC34830


7832
BTG2
BTG family, member 2


23259
DDHD2
DDHD domain containing 2


84981
MGC14376
hypothetical protein MGC14376


6448
SGSH
N-sulfoglucosamine sulfohydrolase (sulfamidase)


9910
RABGAP1L
RAB GTPase activating protein 1-like


1611
DAP
death-associated protein


126823
KARCA1
kelch/ankyrin repeat containing cyclin Al interacting protein


388403
YPEL2
yippee-like 2 (Drosophila)


6720
SREBF1
sterol regulatory element binding transcription factor 1


58476
TP53INP2
tumor protein p53 inducible nuclear protein 2


8605
PLA2G4C
phospholipase A2, group IVC (cytosolic, calcium-independent)


3983
ABLIM1
actin binding LIM protein 1


4189
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9


1604
DAF
decay accelerating factor for complement (CD55, Cromer blood group system)


29994
BAZ2B
bromodomain adjacent to zinc finger domain, 2B


10156
RASA4
RAS p21 protein activator 4


9123
SLC16A3
solute carrier family 16 (monocarboxylic acid transporters), member 3


7846
TUBA3
tubulin, alpha 3


3956
LGALS1
lectin, galactoside-binding, soluble, 1 (galectin 1)


1647
GADD45A
growth arrest and DNA-damage-inducible, alpha


6609
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)


56904
SH3GLB2
SH3-domain GRB2-like endophilin B2


440081
DDX12
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 (CHL1-like helicase




homolog, S. cerevisiae)


5163
PDK1
pyruvate dehydrogenase kinase, isoenzyme 1


25840
DKFZP586A0522
DKFZP586A0522 protein


51566
ARMCX3
armadillo repeat containing, X-linked 3


9388
LIPG
lipase, endothelial


27250
PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)


6302
SAS
sarcoma amplified sequence


83937
RASSF4
Ras association (RaIGDS/AF-6) domain family 4


388677
NOTCH2NL
Notch homolog 2 (Drosophila) N-terminal like


23646
PLD3
phospholipase D family, member 3


23643
LY96
lymphocyte antigen 96


9855
FARP2
FERM, RhoGEF and pleckstrin domain protein 2


65018
PINK1
PTEN induced putative kinase 1


57035
C1orf63
chromosome 1 open reading frame 63


85352
KIAA1644
KIAA1644 protein


283131
TncRNA
trophoblast-derived noncoding RNA


143888
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2


56204
FLJ10980
hypothetical protein FLJ10980


23446
CDW92
CDW92 antigen


23766
GABARAPL3
GABA(A) receptors associated protein like 3


1508
CTSB
cathepsin B


4094
MAF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)


22932
POMZP3
POM (POM121 homolog, rat) and ZP3 fusion


56243
KIAA1217
KIAA1217


1663
DDX11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase




homolog, S. cerevisiae)


1414
CRYBB1
crystallin, beta B1


154091
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12


4121
MAN1A1
mannosidase, alpha, class 1A, member 1


11178
LZTS1
leucine zipper, putative tumor suppressor 1


10628
TXNIP
thioredoxin interacting protein


83719
YPEL3
yippee-like 3 (Drosophila)


9863
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2


5660
PSAP
prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)


145788
FLJ27352
hypothetical LOC145788


84513
HTPAP
HTPAP protein


57612
KIAA1466
KIAA1466 gene


57515
TDE2
tumor differentially expressed 2


29005
PRO1073
PRO1073 protein


51646
YPEL5
yippee-like 5 (Drosophila)


5269
SERPINB6
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6


30061
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1


81030
ZBP1
Z-DNA binding protein 1


347733
RP11-506K6.1
tubulin, beta polypeptide paralog


390
RND3
Rho family GTPase 3


10765
JARID1B
Jumonji, AT rich interactive domain 1B (RBP2-like)


9783
RIMS3
regulating synaptic membrane exocytosis 3


27122
DKK3
dickkopf homolog 3 (Xenopus laevis)


151556
GPR155
G protein-coupled receptor 155


8365
HIST1H4H
histone 1, H4h


6480
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1


6591
SNAI2
snail homolog 2 (Drosophila)


54800
DRE1
DRE1 protein


3669
ISG20
interferon stimulated exonuclease gene 20kDa


23710
GABARAPL1
GABA(A) receptor-associated protein like 1


400172
LOC400172
similar to KIAA1641 protein; melanoma-associated antigen; CLL-associated




antigen KW-1


153222
LOC153222
adult retina protein


54981
C9orf95
chromosome 9 open reading frame 95


5641
LGMN
legumain


257019
FRMD3
FERM domain containing 3


8357
HIST1H3H
histone 1, H3h


55281
FLJ11000
hypothetical protein FLJ11000


4050
LTB
lymphotoxin beta (TNF superfamily, member 3)


203
AK1
adenylate kinase 1


5920
RARRES3
retinoic acid receptor responder (tazarotene induced) 3


284801
LOC284801
hypothetical protein LOC284801


150271
LOC150271
hypothetical protein LOC150271.

33. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising:
testing a sample obtained from the patient after administration of the inhibitor to measure gene expression of at least one biomarker selected from the group consisting of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A, wherein at least one selected biomarker is CCL3,
wherein detection of an alteration in level of expression compared to a baseline gene expression measurement of the at least one biomarker is indicative of the candidacy of the patient for treatment,
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

34. A method of monitoring response of a patient to treatment by an inhibitor of FGFR3 for a cell proliferative disorder, the method comprising:
testing a sample obtained from the patient after administration of the inhibitor of FGFR3 to measure gene expression of at least one biomarker selected from the group consisting of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A, wherein at least one selected biomarker is CCL3,
wherein detection of an alteration in level of expression of the at least one biomarker compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.