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# I . Ppoduct and c®mpany uderafitucaftuon

Product name : Tivida"I FL 2500 Product code : 1.02458 Supplier : EMD Chemicals An Affiliate of Merck KGaA, Darmstadt Germany One Internationa' Plaza Suite 300 Philadelphia, PA 19113 888-367-3275 Material uses : Coating agents Validation date : 3/11/2014. In case of emergency : Chemtrec (USA): 800-424-9300 Canutec (Canada): 613-996-6666 24 Hours/Day; 7 Days/Week 

# 2 . Hazards odentoficatu®n Emergency overvievv

Physical state OSHA/HCS status
Routes of entry Inhalation Ingestion Sbcin 

### Eyes Medical conditions

### aggravated by overexposure 

### WARNING! FLAMMABLE LIQUID AND VAPOR. CAUSES SKIN IRRITATION. SERIOUS EYE DAMAGE/ EYE IRRITATION May cause drowsiness and dizziness. CONTAINS MATERIAL THAT MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA. 

### Liquid. This material is considered hazardous by the OSHA Hazard Communication Standard ( 29 CFR 1910.1200). Dermal contact. Eye contact. Inhalation. Ingestion. May be hazardous in case of inhalation (lung irritant). May be hazardous in case of ingestion. Irritating to skin. Severely irritating to eyes. Risk of serious damage to eyes. Repeated or prolonged inhalation of vapors may aggravate respiratory rr:edical conditions.

Seetoxicological information (section 11) 

# D®mp®situ®n/int'®rrnatu®n ®n Angred°uents

Name CAS number % by weight 1-methoxy-2-prcpanol 107-98-2 55 Trade secret acid, TSRN 13-2666399-5862P Trade secret 30 water 7732-18-5 15 *Chemical Identity withheld as a Trade Secret under the OSHA Hazard Communication Standard, 29CFR 1910.1200 (i) (1).



### ~ . I~ur~t ~o~l ~~~~a~~c~~ Eye contact : Check for and remove any contact lenses. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention immediately. Skin contact : In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Clean shoes thoroughly before reuse. Get medical attention immediately.

Continued on next pageTividal FL 2500 1.02458 217 

# 4. Mrst aM measures

Inhalation : Move exposed person to fresh air. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical at;ention immediately. Ingestion : Wash out mouth with water. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention immediately. 

# 5 e Fire-fighting measures
Flammability of the product : Combustible material. 

### Extinguishing media : Use dry chemical, COz, water spray (fog) or foam. iUot suitable : Do not use water jet. Special exposure hazards : Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep fire-exposed containers cool. 

### Hazardous thermal : Decomposition products may include the following materials: decomposition products carbon dioxide carbon monoxide Special protective : Fire-fighters should wear appropriate protective equipment and self-contained breathing equipment for fire-fighters apparatus (SCBA) with a full face-piece operated in positive pressure mode. 

### Special remarks on fire : Combustible material. Vapors are heavier than air and niay spread along floors. Forms hazards explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapors possible in the event of fire. Ambient fire may liberate hazardous vapors . The following may develop in event of fire: hydrogen fluoride 

## 5 e Qcc

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## ,dierficai Wease measures Personal precautions : No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Shut off all ignition sources. No flares, smoking or flames in hazard area. Avoid breathing vapor or mist. Provide 

### adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment (see Section 8). 

### Environmental precautions : Avoid dispersal of spilled material and runoff and contact with soil, waterNays, drains and sewers. Inform the relevant authorities if the produc , ~ has caused environmental pollution (sewers, waterways. soil or air). 

### I'dtethods for cleaninq up Spill : Stop leak if without risk. Move containers from spill area. Approach release from upwind. Prevent entry into sewers, water courses, basements or confined areas. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see section 13). Use spark-proef tools and explosion-proof equipment. Dispose of via a licensed waste disposal contractor. Contaminated abscrbent material may pose the same hazard as the spilled product. Note: see section 1 for emergency contact information and section 13 `or waste disposal. Dilute with water and mop up if water-soluble or absorb with an inert dry material and place in an appropriate waste disposal container.

~ Continued on next page

# L

_ Tivida l FL 2500 1.02458 317 

# 7. Handling and storage Handling : Do not get in eyes, on skin or on clothing. Avoid breathing vapor or mist. Use only with adequate ventilation. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Storage : Store in accordance with local regulations. Store in a segregated and approved area. Store in original container, protected from direct sunlight. Eliminate all ignition sources. Separate from oxidizing materials. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Store between the following temperatures: 5 to 30°C (41 to 86 0 F). 

# 8 . Exposure controls/personal protection
Ingredient Exposure limits 1-methoxy-2-propanol ACGIH TLV (United States, 6/2013). TWA: 50 ppm 8 hour(s). TWA: 184 mg/m' 8 hour(s). STEL: 100 ppm 15 minute(s). STEL: 369 mg/m 3 15 minute(s). OSHA PEL 1989 (United States, 3/1989). TWA: 100 ppm 8 hour(s). TWA: 360 mg/m' 8 hour(s). STEL: 150 ppm 15 minute(s). STEL: 540 mg/m' 15 minute(s). NIOSH REL (United States, 10/2013). TWA: 100 ppm 10 hour(s). TWA: 360 mg/m' 10 hour(s). STEL: 150 ppm 15 minute(s). STEL: 540 mg/m 3 15 minute(s).
Consult local authorities for acceptable exposure limits. Engineering measures

: Use only with adequate ventilation. Use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits. The engineering controls also need to keep gas, vapor or dust concentrations below any lower explosive limits. Use explosion-proof ventilation equipment. Hygiene measures
: Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Personal protection Respiratory
: Vapor respirator or self-contained breathing apparatus (SCBA). Ensure an MSHA/ NIOSH-approved respirator is used. Hands
: Chemical-resistant, corrosive resistant, impervious to FL 2300 gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Eyes
: Safety eyewear complying with an approved standard should be used when a risk assessment, by a qualified Industrial Hygienist, indicates their use to avoid exposure to liquid splashes, mists or dusts. Skin
: Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

Continued on next pageTivida`" FL 2500 1.02458 417 

# 9 .

~ 

# hysecal and chemoca9 pr®pertses
Physical state : Liquid. Flash point : Closed cup: 31 °C (87.8°F) Information refers to the main component Color : Light yellow Odor : Characteristic. pH ; Not available. Boiling/condensation point : Not available. IVlelting/freezing point : Not available. Relative density : Not available. llapor pressure : Not available. Vapor density : Not available. Odor threshold : Not available. Evaporation rate : Not applicable vOC : 55 % (w/w) Solubility : Soluble 

# 10 . StaboMy and rr°eactovity
Chemical stability : The product is stable. 

## T®xec®0®gical onf®rmati®n
Acute toxicity Product/ingredient name Test Route Species Result 1-methoxy-2-propanol LD50 Dermal Rabbit 13 g/kg LD50 Rat 3720 mg/kg Intraperitoneal LD50 Intravenous Rat 4200 mg/kg LD50 Oral Mouse 11700 mg/kg LD50 Oral Rat 6600 mg/kg LD50 Oral Rabbit 5700 mg/kg LD50 Rat 7800 mg/kg Subcutaneous LDLo Oral Rat 3739 mg/kg LC50 Inhalation Rat 10000 ppm 

### Gas.

Species Score Observation

Rabbit - - Rabbit - -

EPA NIOSH I'dTP OSHA

- None. - - Irritation/Corrosion Product/ingredient name 1-methoxy-2-propanol

Carcinoqenicity Classification Product/ingredient name 1-methoxy-2-propanol Result Eyes - Mild irritant Skin - Mild irritant

ACGIFi IARC 

### A4 - No known significant effects or critical hazards. 

### Niutaqenicity No known significant effects or critical hazards. 

### Teratogenicity No known significant effects or critical hazards.



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# L

— Tivida

~ " FL 2500 1.02458 517 

# 12. Ec®I®gical inf®rmatu®n
Acauatic ecotoxicity Product/ingredient name Result Species Exposure Tivida" FL 2500 EC50 >100 mg/I Daphnia 48 hours EC50 >100 mg/I Algae 72 hours Environmental effects : No known significant effects or critical hazards. 

## 13 . ®isp®sal c®nsudlerati®ns The information presented only applies to the material as supplied. The identification based on characteristic(s) or listing may not apply if the material has been used or othenNise contaminated. It is the responsibility of the waste generator to determine the toxicity and physical properties of the material generatec to determine the proper waste identification and disposal methods in compliance with applicable regulations. Disposal should be in accordance with applicable regional, national and local laws and regulations. 

## 1~ 

## . Transp®rt inf®rrnati®n
Regulatory UN number Proper shipping Classes PG* Label Additional information name information
DOT Classification UN3092 1-Methoxy-2-propanol 3 III -

IATA-DGR Class UN3092 1-Methoxy-2-propanol 3 III

PG' : Packing group



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## at®ry unformata®n

United States U.S. Federal regulations : FOR RESEARCH AND DEVELOPPJIENT USE ONLY. Use under the supervision of qualified personnel. SARA 302/304/311/312 extremely hazardous substances: No products were found. 

### SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: 1-methoxy-2-propanol SARA 311/312 MSDS distribution - chemical inventory - hazard identification: 1- methoxy-2-propanol: Fire hazard, Immediate (acute) health hazard, Delayed (chronic) health hazard Connecticut Carcinogen : None of the components are listed. Reporting Connecticut Hazardous : None of the components are listed. 

### Material Survey Florida substances : None of the components are listed. Illinois Chemical Safety Act : None of the components are listed.
Illinois Toxic Substances : None of the components are listed Disclosure to Employee Act Louisiana Spill Louisiana Reporting fdlassachusetts Spill
PUlassachusetts Substances 

### Minnesota Hazardous Substances : None of the components are listed : None of the components are listed : None of the components are listed : None of the components are listed : None of the components are listed

Continued on next pageTivida'" , FL 2500 1.02458 617 

# 15 . Regula$®rry unf®rmatu®n
Michigan Critical Material filew Jersey Toxic Catastrophe Prevention Act New Jersey Spill New Jersey Hazardous Substances New York Toxic Chemical Release Reporting New York Acutely Hazardous Substances Pennsylvania RTK Hazardous Substances Rhode Island Hazardous Substances Canada WHMIS (Canada) : Class B-2: Flammable liquid None of the components are listed. None of the components are listed.

None of the components are listed. None of the components are listed.

None of the components are listed.

None of the components are listed.

None of the components are listed.

None of the components are listed.

Canadian lists : CEPA Toxic substances: None of the components are 'isted. Canadian ARET: None of the components are listed. Canadian NPRI: None of the components are listed. Alberta Designated Substances: None of the components are listed. Ontario Designated Substances: None of the components are listed. Quebec Designated Substances: None of the components are listed. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all the information required by the Controlled Products Regulations.
EU reclulations Risk phrases : R10- Flammable. R67- Vapors may cause drowsiness and dizziness. Safety phrases : S2- Keep out of the reach of children.

International requlations 

# 16. ®fhec unf®a°mafi®n

Hazardous Material Information System (U.S.A.) Health Flammability Physical 3
3
hazards 10

Caution: HMISO ratings are based on a 0-4 rating scale, with 0 representing minimal hazards or risks, and 4 representing significant hazards or risks Although HMISO ratings are not required on MSDSs under 29 CFR 1910. 1200, the preparer may choose to provide them. HMISO ratings are to be used with a fully implemented HMISO program. HMISO is a registered mark of the hlational Paint & Coatings Association (NPCA). HMISO materials may be purchased exclusively from J. J. 14eller (800) 327-6868.
National Fire Protection Association (U.S.A.)
^
, Flammability
Health > Instability

Special

Continued on next page

### TividaI FL 2500 1.02458 7/7 

# 16. Other unf®rmafl®n Other special : No additional information. considerations 

### Notice to reader The statements contained herein are based upon technical data that EhiID Millipore Corporation believes to be reliable, are offered for information purposes only and as a guide to the appropriate precautionary and emergency handling of the material by a properly trained person having the necessary technical skills. Users should consider these data only as a supplement to other information gathered by them and must make independent determinations of suitability and completeness of information from all sources to assure proper use, storage and disposal of these materials and the safety and health of employees and customers and the protection of the environment. EfVID MILLIPORE CORPORATION IVIAKES iV0 REPRESENTATIOfd OR WARRAIVTY OF AhlY KIfVD, EXPRESS OR IMPLIED, INCLUDIIVG f1flERCHANTABILITY OR FITNESS FOR A PARTICULAR USE, NUITH RESPECT TO THE IIVFORMATIOIV HEREIIV OR THE PRODUCT TO WHICH THE INFORMATIOIV REFERS.