### Mandipropamid Dietary Exposure and Risk Assessment

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, 

### D.C. 20460 DP Number: D428940

OFFICE OF CHEMICAL SAFETY
AND POLLUTION PREVENTION



### MEMORANDUM

Date: February 23, 2016

SUBJECT: Mandipropamid: Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Amended Use of the Fungicide on Potato to Add Seed Treatment Use

.

PC Code: 036602
Decision No.: 497834
Petition No.: 4F8329
Risk Assessment Type: Dietary
TXR No.: None
MRID No.: None DP Number: 0428940 Registration No.: 100-1254 Regulatory Action: Section 3
Case No.: 7058
CAS No.: 374726-62-2
40 CFR: §180.637

FROM: El i zabeth Holman, Physica l Scientist

### ~ 

## H.re--

Risk Assessme n t 

### Branc h 2
Health Effects Divisio n (7509P)



### THROUGH: David H r dy, Sen i o r

## Bi**og ~/~**  K:istin Rury, B i.ologist 

# ¥-**~** D i etary Exposure Sc i ence Adv i sory Co un ci l <DESAC)
Health 

### Etlects Divis i on (7509P)



### TO: Ton y Kish and Shaunta Hill

, RM Team 22 Fungicide Branch (FB) Registration Division (RD)

, 7505P



### Executive Summary

Chronic aggregate dietary [food and drinking water] exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption
data from the U.S

. Department of Agriculture's (USDA ' s) National Health and Nutrition
E x amination Surve y, What We Eat in America

, (NHANES / WWEIA). The analysis was

Page 1of10

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 2 of 10 on potatoes to add seed piece treatment. This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1.

In calculating dietary risk estimates, HED has compared the chronic population adjusted dose (cPAD) to the respective estimated dietary exposures. Typically, HED has concerns regarding dietary risk when the estimates exceed 100% of the cPAD. No single dose effects were noted in the toxicity studies for mandipropamid, so an acute dietary point of departure was not selected and an acute dietary exposure and risk assessment was not conducted. In addition, mandipropamid is considered “not likely” to be carcinogenic; therefore a cancer assessment was not performed.

Chronic Dietary (Food + Drinking Water) Exposure Results and Characterization

An unrefined chronic dietary analysis for mandipropamid was conducted. Specifically, theassumptions underlying this unrefined assessment were 100% crop treated (CT), HEDrecommended tolerance levels or tolerance level residues (with the exception of vegetable, tuberous and corm, crop subgroup 1C (which includes the SYN 500003 metabolite)), and default
DEEM-FCID  (ver. 7.81) processing factors (with the exception of chemical-specific empirical processing factors (PF) described in Table 1). The mean (i.e., relevant to chronic exposure) drinking water estimate of 79 ppb (μg/L) was pr ovided by the Environmental Fate and Effects Division (EFED) and directly incorporated into the chronic assessment. The estimated drinking water concentration (EDWC) of 79 μg/L reflects ground water exposure, and was used for chronic exposure.

For the general U.S. population, the exposure from food and drinking water utilizes 26% of the chronic population adjusted dose (cPAD). The chr onic dietary risk estimate for the most highly exposed population subgroup, children 1-2 years old, is 42% of the cPAD. The chronic dietary risk assessment shows that for all included commodities, the chronic dietary risk estimates are below the Agency’s level of concern (i.e. <100% cPAD).

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, e.g. no observed adve rse effect level (NOAEL), lowest observed adverse effect level (LOAEL)) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.regulations.gov/#!documen tDetail;D=EPA-HQ-OPP-2007-0780-0001 ; or see SOP 99.6 (20-AUG-1999).

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 3 of 10 The most recent dietary risk assessment for mandipropamid was conducted by D. McNeilly (D412238, 08/27/2013).

II. Residue Information

Tolerances: Permanent tolerances for residues of mandipropamid are listed in 40 CFR §180.637 and are expressed in terms of mandipr opamid [4-chloro-N-[2-[3-methoxy-4-(2- propynyloxy)phenyl]ethyl]- α -(2-propynyloxy)-benzeneacetamide] in/on a variety of raw agricultural commodities (RACs), ranging from 0.01 ppm to 240 ppm. Based on the registered and proposed uses, livestock commodity tolerances are not required, as there is no reasonable expectation of finite residues in livestock (40CFR §180.6[a][3]) (D428278, W. Drew, 02/23/2016).

Residues of Concern (residues included in dietary exposure analysis): For most agricultural commodities the residues of concern for tolerance enforcement and risk assessment are parent only, except for vegetable, tuberous and corm, subgroup 1C where the metabolite SYN 500003 has been included for exposure/risk assessment (Residue chemistry memoranda D333121 & D328534; D. McNeilly; 28-Aug-2007). For drinking water, the parent plus the metabolites SYN 500003 and SYN 504851 are included in the exposure/risk assessment.

Current Tolerances: The chronic dietary risk assessment was based on the assumption of tolerance-level residues for all commodities with existing tolerances.

Recommended Tolerance: The HED-recommended tolerance-level residues for the proposed amended use on potato (D428278, W. Drew, 02/23/2016) is 0.09 ppm, with the amended tolerance being issued for the entire vegetable, tuberous and corm, subgroup 1C. For the purposes of this chronic dietary risk assessment, this subgroup was assessed at 0.115 ppm (D428278, W. Drew, 02/23/2016), which assumes tolerance-level residues of parent mandipropamid (0.09 ppm) and also includes the SYN 500003 metabolite in parent-equivalents (at 0.025 ppm).

Tolerance Summary for Mandipropamid. Commodity Established
Tolerance

(ppm) Proposed
Tolerance

(ppm) Tolerance
Recommended by HED (ppm) Comments; C orrect Commodity Definition

Vegetable, tuberous and corm, subgroup 1C 0.01* None 0.09 1 Based on the submitted potato field trial data for seed treatment. * A tolerance is currently established at the liste d tolerance level in the corresponding commodity.

1 For the purposes of the dietary exposure assessment, 0.115 ppm has been used for subgroup 1C commodities, in order to account for the parent + SYN 500003 metabolite residues.



### Residue Data used for the Chronic Dietary Assessment: HED used recommended and established tolerance-level residues and assumed that 100% of the crops were treated with mandipropamid for the chronic dietary assessment. As summarized in Table 1, DEEM default processing factors were used for the following commodities: grape juice, dried onion, dried potato, dried tomato, tomato puree, and tomato pa ste; an empirical processing factor was used for grape, wine/sherry (1.5 ppm). A processing factor was not used for grape, raisin because a raisin tolerance value is currently established. The USDA Pesticide Data Program (PDP)

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 4 of 10 monitored pesticide residues in catfish in 2008, 2009, and 2010. In general, pesticide residues would not be expected to be found in fish unless the pesticide bioaccumulates or has an aquatic use. To determine whether or not residues are present in fish, HED now routinely checks PDP monitoring data regardless of the pesticide’s uses and physicochemical properties. However, PDP did not analyze catfish samples for mandipropa mid. As a result, residues in fish were not included in the assessment.

Table 1. Mandipropamid Processing Factors. Commodity Processing Factors (ppm) Grape
Raisin Not used, raisin tolerance value was used
Juice 1.2 Wine/Sherry 1.5 (empirical value) Potato – dry 6.5 Onion – dried 9.0
Tomato
Paste 5.4
Puree 3.3 Dried 14.3



### III. Percent Crop Treated Information

The chronic assessment is based on 100% crop treated assumptions for all commodities.

IV. Drinking Water Data Drinking Water Exposure Assessment for Proposed Section 3 New Uses on: Basil, Ginseng and Succulent Beans; and Expanded Uses on Bulb Vegetables, Cucurbits, Grap es, and Fruiting Vegetables including Tomatoes., D409108, R. Shamblen, 7/9/2013.



### EFED conducted a Tier 1 drinking water exposur e assessment for the fungicide mandipropamid. PRZM-GW was used to estimate mandipropamid exposure in ground water. Maximum estimated drinking water concentrations (EDWCs) in ground water are 87 and 79 μg/L for acuteand chronic exposures, respectively. These values are as much as 480 times higher than SCIGROW model results. Maximum acute and chronic EDWCs in surface waters are 79 and 9.0 μg/L, respectively. EFED has concluded that the proposed amended use on potato has no impact on the drinking water estimates (based on email communication with B. Anderson, 08/24/2015). Therefore, the drinking water estimates from the existing use pattern have been used in this

assessment.

Table 2. Tier 1 Estimated Drinking Wat er Concentrations (EDWC) for Maximum Mandipropamid Use Patterns. Drinking Water Source (Model, Version) PCA (%) Crop Use Pattern (Maximum Annual Rate) Acute ( μ g/L) Chronic ( μ g/L)

Surface Water (FIRST, 1.1.1) 91 Tomato & Basil (2.08 lbs a.i./A) 79 9.0

Ground Water (PRZM-GW, 1.01) N/A Tomato & Basil (2.08 lbs a.i./A) 87 79

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 5 of 10 Ground Water (SCI-GROW, 2.3) N/A Tomato & Basil (2.08 lbs a.i./A) 0.18

Abbreviations: A= acre; a.i. = active ingredient; μ g = micrograms; lbs = pounds (US); N/A = not applicable



### The Total Residue (TR) modeling approach (USEPA, 2013) was used to estimate aerobic aquatic half-lives, and estimate drinking water concentrations in surface waters. Previous drinking water assessments calculated separate half-lives for the parent compound and two degradates of concern, for which exposure was estimated with separate model runs. Simple addition of the exposure estimates for mandipropamid and it’s degradates of concern was used to generate estimated drinking water concentrations. Previous authors acknowledge this approach is conservative because the exposure estimates may not be temporally coincident. The TR method, however, tallies the parent compound and it’s degradates of concern prior to calculating a Total Residue half-life using PestDF.

The PRZM-GW chronic ground water value was higher than the surface water value. As a result, the ground water value was incorporated directly into these dietary assessments under the DEEM-FCID food categories “water, all sources” a nd “water, indirect, all sources.” The FIRST model and its description are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/

.

V. DEEM-FCIDTM Program and Consumption Information

The mandipropamid chronic dietary exposure a ssessment was conducted using the DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g., appl es, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, ba ked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003-2008 WWEIA consum ption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

VI. Toxicological Information

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 6 of 10 HED evaluated the toxicology data base of ma ndipropamid and selected a dose and endpoint for chronic dietary risk assessment based on evidence of liver toxicity. No acute dietary exposure assessment for mandipropamid has been conducted because no appropriate endpoint attributable to a single dose was identified. There were no treatment-related tumors observed in carcinogenicity studies in rats and mice and mandipropamid is classified as “Not likely to be a human carcinogen.” Therefore, cancer risk is not a concern for this chemical. Doses and toxicological endpoints selected for the chroni c dietary exposure scenario are summarized in Table 3.

Table 3. Summary of Toxicological Doses and E ndpoints for Use in Dietary Human Health Risk Assessments for Mandipropamid Exposure Scenario Dose Used in Risk Assessment, UF
POD FQPA SF and Level of Concern for Risk
Assessment Study and Toxicological Effects

Acute Dietary (All populations, including infants and children) None None Not selected.

No appropriate dose and endpoint could be identified for any population group. Chronic Dietary (All populations) NOAEL= 5 mg/kg/day
UF A = 10x
UF H = 10x

Chronic RfD = 0.05 mg/kg/day FQPA SF =1 cPAD = chronic RfD FQPA SF

= 0.05 mg/kg/day Chronic toxicity – dogs LOAEL = 40 mg/kg/day, based on evidence of liver toxicity (increased incidence and severity of microscopic pigment in the liver and increased alkaline phosphatase activity in both sexes as well as increased alanine aminotransferase activity in males). Cancer (oral, dermal, inhalation) There were no treatment-related tumors observe d in carcinogenicity studies in rats and mice. Classified as “Not likely to be a human carcinogen.” Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning of extrapolation to determine ri sk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. L OAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intrasp ecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose.



### VII. Results/Discussion

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM-FCIDTM analysis estimates the dietary exposure of the general U.S. population and various population subgroups. Table 4 lists the results of the chronic dietary exposure analyses for the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years old.

Results of Chronic Dietary Exposure Analysis

In the chronic dietary exposure analysis, the most highly exposed population subgroup is children 1-2 years old which utilizes 42% of the cPAD (Table 4). The general U.S. population utilizes 26% of the cPAD.

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 7 of 10 Table 4. Summary of Dietary Exposure and Risk for Mandipropamid (Food and Drinking Water)

Population Subgroup Acute Dietary Chronic Dietary Cancer Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD Dietary Exposure (mg/kg/day) Risk General U.S. Population

N/A N/A 0.013145 26

N/A N/A All Infants (< 1 year old) 0.011004 22 Children 1-2 years old 0.021060 42 Children 3-5 years old 0.019313 39 Children 6-12 years old 0.012005 24 Youth 13-19 years old 0.009525 19 Adults 20-49 years old 0.013220 26 Adults 50-99 years old 0.013149 26 Females 13-49 years old 0.013039 26 N/A = Not applicable.



### VIII. Characterization of Inputs/Outputs

This analysis is considered highly conservative dietary exposure assessment. An unrefined chronic dietary exposure analysis was performe d for chronic exposure to mandipropamid using DEEM-FCIDTM. Tolerance-level residues for all commodities, except vegetable, tuberous and corm, subgroup 1C, DEEM (ver. 7.81) default processing factors (except grape, wine and sherry, 1.5X) and 100% crop treated were assumed for this assessment. Further refinement to the analyses could be made through the use of anticipated residues, incorporation of percent crop treated information with mandipropamid, and/or monitoring data that better reflect residues at the time of consumption. Since risk estimates are below HED’s level of concern, a more highly refined analysis is not needed at this time.

IX. Conclusions

Based on the conservative assumptions noted above, chronic dietary risk estimates for mandipropamid do not exceed HED’s level of concern for the general U.S. population, or any of the population subgroups, including those comprised of infants and children.

X. List of Attachments :

Attachment 1: Residue Input File for Chronic Analysis Attachment 2: Results of Chronic Dietary Exposure Analysis

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 8 of 10 Attachment 1: Residue Input File for Chronic (Non-Cancer) Analysis

Filename: F:\Mandipropamid\Dietary\036602C_100615.R08 Chemical: Mandipropamid RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 10-06-2015/17:13:24 Program ver. 3.16, 03-08-d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101168000 1AB Ginseng, dried 0.300000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.115000 1.000 1.000 0103015001 1CD Arrowroot, flour-babyfood 0.115000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.115000 1.000 1.000
0103082000 1CD Cassava 0.115000 1.000 1.000 0103082001 1CD Cassava-babyfood 0.115000 1.000 1.000 0103139000 1CD Dasheen, corm 0.115000 1.000 1.000 0103166000 1CD Ginger 0.115000 1.000 1.000 0103166001 1CD Ginger-babyfood 0.115000 1.000 1.000 0103167000 1CD Ginger, dried 0.115000 1.000 1.000 0103296000 1C Potato, chips 0.115000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.115000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)-b 0.115000 6.500 1.000 0103298000 1C Potato, flour 0.115000 6.500 1.000 0103298001 1C Potato, flour-babyfood 0.115000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.115000 1.000 1.000 0103299001 1C Potato, tuber, w/peel-babyfood 0.115000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.115000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel-babyfood 0.115000 1.000 1.000 0103366000 1CD Sweet potato 0.115000 1.000 1.000 0103366001 1CD Sweet potato-babyfood 0.115000 1.000 1.000 0103371000 1CD Tanier, corm 0.115000 1.000 1.000 0103387000 1CD Turmeric 0.115000 1.000 1.000 0103406000 1CD Yam, true 0.115000 1.000 1.000 0103407000 1CD Yam bean 0.115000 1.000 1.000 0301165000 3A Garlic, bulb 0.050000 1.000 1.000 0301165001 3A Garlic, bulb-babyfood 0.050000 1.000 1.000 0301237000 3A Onion, bulb 0.050000 1.000 1.000 0301237001 3A Onion, bulb-babyfood 0.050000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.050000 9.000 1.000 0301238001 3A Onion, bulb, dried-babyfood 0.050000 9.000 1.000 0301338000 3A Shallot, bulb 0.050000 1.000 1.000 0302103000 3B Chive, fresh leaves 4.000000 1.000 1.000
0302198000 3B Leek 4.000000 1.000 1.000 0302239000 3B Onion, green 4.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 4.000000 1.000 1.000 0401005000 4A Amaranth, leafy 20.000000 1.000 1.000 0401018000 4A Arugula 20.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 20.000000 1.000 1.000 0401133000 4A Cress, garden 20.000000 1.000 1.000 0401134000 4A Cress, upland 20.000000 1.000 1.000 0401138000 4A Dandelion, leaves 20.000000 1.000 1.000 0401150000 4A Endive 20.000000 1.000 1.000 0401204000 4A Lettuce, head 20.000000 1.000 1.000 0401205000 4A Lettuce, leaf 20.000000 1.000 1.000 0401248000 4A Parsley, leaves 20.000000 1.000 1.000 0401313000 4A Radicchio 20.000000 1.000 1.000 0401355000 4A Spinach 20.000000 1.000 1.000 0401355001 4A Spinach-babyfood 20.000000 1.000 1.000
0402076000 4B Cardoon 20.000000 1.000 1.000 0402085000 4B Celery 20.000000 1.000 1.000 0402085001 4B Celery-babyfood 20.000000 1.000 1.000 0402086000 4B Celery, juice 20.000000 1.000 1.000
0402087000 4B Celtuce 20.000000 1.000 1.000 0402152000 4B Fennel, Florence 20.000000 1.000 1.000 0402322000 4B Rhubarb 20.000000 1.000 1.000 0402367000 4B Swiss chard 20.000000 1.000 1.000 0501061000 5A Broccoli 3.000000 1.000 1.000 0501061001 5A Broccoli-babyfood 3.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 0501064000 5A Brussels sprouts 3.000000 1.000 1.000

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 9 of 10 0501069000 5A Cabbage 3.000000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 3.000000 1.000 1.000 0501083000 5A Cauliflower 3.000000 1.000 1.000 0501196000 5A Kohlrabi 3.000000 1.000 1.000 0502063000 5B Broccoli raab 25.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 25.000000 1.000 1.000
0502117000 5B Collards 25.000000 1.000 1.000 0502194000 5B Kale 25.000000 1.000 1.000 0502229000 5B Mustard greens 25.000000 1.000 1.000 0502318000 5B Rape greens 25.000000 1.000 1.000 0502389000 5B Turnip, greens 25.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.900000 1.000 1.000 0601043001 6A Bean, snap, succulent-babyfood 0.900000 1.000 1.000 0801374000 8A Tomatillo 1.000000 1.000 1.000
0801375000 8A Tomato 1.000000 1.000 1.000 0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 0801376000 8A Tomato, paste 1.000000 5.400 1.000 Tomato Full comment: Tomato processing study 0801376001 8A Tomato, paste-babyfood 1.000000 5.400 1.000 ' 0801377000 8A Tomato, puree 1.000000 3.300 1.000 ' 0801377001 8A Tomato, puree-babyfood 1.000000 3.300 1.000 ' 0801378000 8A Tomato, dried 1.000000 14.300 1.000 0801378001 8A Tomato, dried-babyfood 1.000000 14.300 1.000 0801379000 8A Tomato, juice 1.000000 1.500 1.000 0801380000 8A Tomato, Tree 1.000000 1.000 1.000 0802148000 8BC Eggplant 1.000000 1.000 1.000 0802234000 8BC Okra 1.000000 1.000 1.000 0802270000 8B Pepper, bell 1.000000 1.000 1.000 0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 0901075000 9A Cantaloupe 0.600000 1.000 1.000 0901187000 9A Honeydew melon 0.600000 1.000 1.000 0901399000 9A Watermelon 0.600000 1.000 1.000 0901400000 9A Watermelon, juice 0.600000 1.000 1.000 0902021000 9B Balsam pear 0.600000 1.000 1.000 0902088000 9B Chayote, fruit 0.600000 1.000 1.000 0902102000 9B Chinese waxgourd 0.600000 1.000 1.000
0902135000 9B Cucumber 0.600000 1.000 1.000 0902308000 9B Pumpkin 0.600000 1.000 1.000 0902309000 9B Pumpkin, seed 0.600000 1.000 1.000 0902356000 9B Squash, summer 0.600000 1.000 1.000 0902356001 9B Squash, summer-babyfood 0.600000 1.000 1.000 0902357000 9B Squash, winter 0.600000 1.000 1.000 0902357001 9B Squash, winter-babyfood 0.600000 1.000 1.000 1100173500 11 Goji berry 1.000000 1.000 1.000 1302174000 13B Gooseberry 1.400000 1.000 1.000 1304175000 13D Grape 1.400000 1.000 1.000 1304176000 13D Grape, juice 1.400000 1.200 1.000 1304176001 13D Grape, juice-babyfood 1.400000 1.200 1.000 1304179000 13D Grape, wine and sherry 1.400000 1.500 1.000 PF fro Full comment: PF from grape processing study. 1901028000 19A Basil, fresh leaves 30.000000 1.000 1.000 1901028001 19A Basil, fresh leaves-babyfood 30.000000 1.000 1.000 1901029000 19A Basil, dried leaves 240.000000 1.000 1.000 Sectio Full comment: Section 18 1901029001 19A Basil, dried leaves-babyfood 240.000000 1.000 1.000 Sectio Full comment: Section 18 8601000000 86A Water, direct, all sources 0.079000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.079000 1.000 1.000 9500177000 O Grape, leaves 1.400000 1.000 1.000 9500178000 O Grape, raisin 3.000000 1.000 1.000 Tolera
Full comment: Tolerance 9500188000 O Hop 50.000000 1.000 1.000

### Mandipropamid Dietary Exposure and Risk Assessment DP Number: D428940

Page 10 of 10 Attachment 2: Results of Chronic Dietary Exposure Analysis

US EPA Ver. 3.16, 03-08-d DEEM-FCID Chronic analysis for MANDIPROPAMID NHANES 2003-2008 2-day Residue file name: F:\Mandipropamid\Dietary\036602C_100615.R08 Adjustment factor #2 NOT used. Analysis Date 10-06-2015/17:14:40 Residue file dated: 10-06-2015/17:13:24 Reference dose (RfD, Chronic) = .05 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.013145 26.3% Hispanic 0.011675 23.4% Non-Hisp-White 0.013565 27.1% Non-Hisp-Black 0.011904 23.8% Non-Hisp-Other 0.014327 28.7% Nursing Infants 0.005519 11.0% Non-Nursing Infants 0.013453 26.9%
Female 13+ PREG 0.011642 23.3% Children 1-6 0.019438 38.9% Children 7-12 0.011255 22.5%
Male 13-19 0.009162 18.3% Female 13-19/NP 0.009887 19.8% Male 20+ 0.012452 24.9% Female 20+/NP 0.013912 27.8% Seniors 55+ 0.012941 25.9%
All Infants 0.011004 22.0% Female 13-50 0.013021 26.0% Children 1-2 0.021060 42.1% Children 3-5 0.019313 38.6% Children 6-12 0.012005 24.0%
Youth 13-19 0.009525 19.0% Adults 20-49 0.013220 26.4% Adults 50-99 0.013149 26.3% Female 13-49 0.013039 26.1%

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