Exhibit 10.26

# SECOND AMENDMENT TO
FACILITY RESERVATION AGREEMENT

This
Second Amendment to Facility Reservation Agreement (the Second
Amendment) is entered into and effective as of December 31, 2003 by and between
Cardinal Health 406, Inc. (formerly known as Packaging Coordinators, Inc.), a Pennsylvania
corporation (Cardinal Health), and MedImmune Vaccines, Inc., a Delaware
corporation (MedImmune), and amends that certain Facility Reservation
Agreement, dated as of October 31, 1997 (the Original Agreement), by
and between Packaging Coordinators, Inc. and Aviron, Inc., a Delaware corporation, as
predecessor-in-interest to MedImmune, as amended by that certain First Amendment to
Facility Reservation Agreement, dated as of August 1, 2002 (the First
Amendment). The Original Agreement, as amended by the First Amendment and this
Second Amendment is referred to as the Agreement.

The
parties agree as follows:

1.       
          Term. Paragraph 2.2 of the Original Agreement, as amended by the
          First Amendment, is hereby deleted in its entirety and replaced by the
          following:

| | This
Agreement shall be effective as of the Effective Date and, unless extended as provided in
this Agreement or earlier terminated as set forth in this Agreement or Section 10.9 of the
Production Agreement, shall end on December 31, 2004 (the Agreement Expiration
Date). The term of this Agreement may be extended by MedImmune for up to three (3)*
additional periods of three (3) years* each provided MedImmune gives written notice to
Cardinal Health of its intention to extend the term at least six (6) months* prior to
expiration in each case, but MedImmune may only extend the term of this Agreement if it
also extends the term of the Production Agreement to terminate concurrently with this
Agreement.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2.       
          Base Monthly Fee. The Base Monthly Fee(as that term is defined in Paragraph 1.1 of the Original
          Agreement, as amended by the First Amendment) shall mean the base monthly fee
          for each calendar year during the term of the Agreement set forth in Exhibit
          A to this Second Amendment for calendar years through 2010. For calendar
          years 2011 through 2013, MedImmune and Cardinal Health will negotiate in good
          faith to determine the Base Monthly Fee on or before January 1, 2008.

3.       
          Production Agreement. The term Production Agreement,
          as defined in Paragraph 1.1 of the Original Agreement shall mean and refer to
          the Production Agreement as originally defined, and all amendments, extensions
          and restatements thereof made from time to time by the parties, including,
          without limitation, the Second Amended and Restated Production Agreement being
          entered into contemporaneously with this Second Amendment.

4.       
          Notices.   Notices to MedImmune should be sent to the following
          address (or such other address as MedImmune may specify in writing):

MedImmune
Vaccines, Inc.                c/o MedImmune, Inc. 
               35 West Watkins Mill Road 
               Gaithersburg, Maryland 20878 
               Attention: Legal Department

Notices
to Cardinal Health should be sent to the following address (or such other address as
Cardinal Health may specify in writing):

Cardinal Health 
               Packaging Services 
               3001 Red Lion Road
               Philadelphia, Pennsylvania 19114
               Attn: President
               With a copy to:
               Cardinal Health, Inc.
               7000 Cardinal Place
               Dublin, Ohio 43017
               Attn: Vice President and Associate General Counsel,Pharmaceutical Technologies & Services

5.       
          Publicity. The following provision is added to the Agreement as
          Section 12.12:

| | 12.12
Publicity. Neither party will make any press release or other public disclosure
regarding this Agreement or the transactions contemplated hereby without the other
partys express prior written consent, except as required under applicable law or by
any governmental agency, in which case the party required to make the press release or
public disclosure shall use commercially reasonable efforts to obtain the approval of the
other party as to the form, nature and extent of the press release or public disclosure
prior to issuing the press release or making the public disclosure.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

6.       
          Other Changes. Except as specifically amended by the terms of this
          Second Amendment, the Original Agreement, as amended by the First Amendment, is
          and shall remain in full force and effect in accordance with its terms.

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The
parties have caused this Second Amendment to be executed by their respective duly
authorized officers or representatives as of the date set forth in the preamble to this
Second Amendment.

CARDINAL
HEALTH 406, INC.

         By:       /s/ Renard Jackson
         Name:       Renard Jackson
         Title:        EVP Sales, Business Development

MEDIMMUNE
VACCINES, INC.


         By:       /s/ Edward V. Arcuri
         Name:       Edward V. Arcuri
         Title:        Sr. VP Manufacturing