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                                                                     Exhibit 4.3

                                LOCK-UP AGREEMENT

     THIS AGREEMENT (this "Agreement") is dated as of May 4, 2005 by and among
Prescient Applied Intelligence, Inc., a Delaware corporation (the "Company"),
and the shareholders of the Company listed on Schedule A attached hereto
(collectively, the "Shareholders").

     WHEREAS, to induce the Company and the investors (the "Investors") to enter
into the Common Stock and Warrant Purchase Agreement dated as of the date hereof
(the "Purchase Agreement") by and among the Company and the Investors, the
Shareholders have agreed not to sell any shares of the Company's common stock,
$.001 par value per share (the "Common Stock"), that such Shareholders purchased
pursuant to the Purchase Agreement, except in accordance with the terms and
conditions set forth herein. Capitalized terms used herein without definition
shall have the meanings assigned to such terms in the Purchase Agreement.

     NOW, THEREFORE, in consideration of the covenants and conditions
hereinafter contained, the parties hereto agree as follows:

     1. Restriction on Transfer; Term. The Shareholders hereby agree with the
Company that the Shareholders will not offer, sell, contract to sell, assign,
transfer, hypothecate, pledge or grant a security interest in, or otherwise
dispose of, or enter into any transaction which is designed to, or might
reasonably be expected to, result in the disposition of (whether by actual
disposition or effective economic disposition due to cash settlement or
otherwise by the Company or any affiliate of the Company or any person in
privity with the Company or any affiliate of the Company), directly or
indirectly, any of the shares of Common Stock for a period of one (1) year
following the date of this Agreement (the "Period").

     2. Ownership. During the Period, the Shareholders shall retain all rights
of ownership in the Common Stock, including, without limitation, voting rights
and the right to receive any dividends, if any, that may be declared in respect
thereof.

     3. Company and Transfer Agent. The Company is hereby authorized to disclose
the existence of this Agreement to its transfer agent. The Company and its
transfer agent are hereby authorized to decline to make any transfer of the
Common Stock if such transfer would constitute a violation or breach of this
Agreement and the Purchase Agreement.

     4. Notices. All notices, demands, consents, requests, instructions and
other communications to be given or delivered or permitted under or by reason of
the provisions of this Agreement or in connection with the transactions
contemplated hereby shall be in writing and shall be deemed to be delivered and
received by the intended recipient as follows: (i) if personally delivered, on
the business day of such delivery (as evidenced by the receipt of the personal
delivery service), (ii) if mailed certified or registered mail return receipt
requested, four (4) business days after being mailed, (iii) if delivered by
overnight courier (with all charges having been prepaid), on the business day of
such delivery (as evidenced by the receipt of the overnight courier service of
recognized standing), or (iv) if delivered by facsimile transmission,
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on the business day of such delivery if sent by 6:00 p.m. in the time zone of
the recipient, or if sent after that time, on the next succeeding business day
(as evidenced by the printed confirmation of delivery generated by the sending
party's telecopier machine). If any notice, demand, consent, request,
instruction or other communication cannot be delivered because of a changed
address of which no notice was given (in accordance with this Section 4), or the
refusal to accept same, the notice, demand, consent, request, instruction or
other communication shall be deemed received on the second business day the
notice is sent (as evidenced by a sworn affidavit of the sender). All such
notices, demands, consents, requests, instructions and other communications will
be sent to the following addresses or facsimile numbers as applicable.

          If to the Company:

          Prescient Applied Intelligence, Inc.
          1247 Ward Avenue, Suite 200
          West Chester, Pennsylvania 19380
          Attention: Stan Szczygiel
          Tel. No.: (610) 719-1600
          Fax No.: (610) 719-6161

          With copies to:

          Montgomery, McCracken, Walker & Rhoads, LLP
          123 South Broad Street
          Avenue of the Arts
          Philadelphia, Pennsylvania 19109
          Attention: Kathleen O'Brien
          Tel. No.: (215) 772-7288
          Fax No.: (215) 772-7620

          and to:

          Kramer Levin Naftalis & Frankel LLP
          1177 Avenue of the Americas
          New York, New York 10036
          Attention: Christopher S. Auguste
          Tel No.: (212) 715-9100
          Fax No.: (212) 715-8000

     If to any of the Shareholders, addressed to such Shareholder at:

          _______________________

          _______________________

          _______________________
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          Attention: ________________
          Tel. No.: (___) ___-____
          Fax No.: (___) ___-____

          With copies to:

          Pillsbury Winthrop Shaw Pittman LLP
          1650 Tysons Boulevard, Suite 1400
          McLean, Virginia 22102-4859
          Attention: Alicia A. Prather
          Tel No.: (703) 770-7996
          Fax No.: (703) 770-79019

or to such other address as any party may specify by notice given to the other
party in accordance with this Section 4.

     5. Amendment. This Agreement may not be modified, amended, altered or
supplemented, except by a written agreement executed by each of the parties
hereto.

     6. Entire Agreement. This Agreement contain the entire understanding and
agreement of the parties relating to the subject matter hereof and supersedes
all prior and/or contemporaneous understandings and agreements of any kind and
nature (whether written or oral) among the parties with respect to such subject
matter, all of which are merged herein.

     7. Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of New York applicable to agreements made
and to be performed in that state, without regard to any of its principles of
conflicts of laws or other laws which would result in the application of the
laws of another jurisdiction. This Agreement shall be construed and interpreted
without regard to any presumption against the party causing this Agreement to be
drafted.

     8. Waiver of Jury Trial. EACH OF THE PARTIES HEREBY UNCONDITIONALLY AND
IRREVOCABLY WAIVES THE RIGHT TO A TRIAL BY JURY IN ANY ACTION, SUIT OR
PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS
CONTEMPLATED HEREBY. EACH OF THE PARTIES UNCONDITIONALLY AND IRREVOCABLY
CONSENTS TO THE EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF NEW YORK
LOCATED IN NEW YORK COUNTY AND THE FEDERAL DISTRICT COURT FOR THE SOUTHERN
DISTRICT OF NEW YORK WITH RESPECT TO ANY SUIT, ACTION OR PROCEEDING ARISING OUT
OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY, AND
EACH OF THE PARTIES HEREBY UNCONDITIONALLY AND IRREVOCABLY WAIVES ANY OBJECTION
TO VENUE IN NEW YORK COUNTY OR SUCH DISTRICT, AND AGREES THAT SERVICE OF ANY
SUMMONS, COMPLAINT, NOTICE OR OTHER PROCESS RELATING TO SUCH SUIT,
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ACTION OR OTHER PROCEEDING MAY BE EFFECTED IN THE MANNER PROVIDED IN SECTION 4.

     9. Severability. The parties agree that if any provision of this Agreement
be held to be invalid, illegal or unenforceable in any jurisdiction, that
holding shall be effective only to the extent of such invalidity, illegally or
unenforceability without invalidating or rendering illegal or unenforceable the
remaining provisions hereof, and any such invalidity, illegally or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction. It is the intent of the
parties that this Agreement be fully enforced to the fullest extent permitted by
applicable law.

     10. Binding Effect; Assignment. This Agreement and the rights and
obligations hereunder may not be assigned by any party hereto without the prior
written consent of the other parties hereby. This Agreement shall be binding
upon and shall inure to the benefit of the parties hereto and their respective
successors and permitted assigns.

     11. Headings. The section headings contained in this Agreement (including,
without limitation, section headings and headings in the exhibits and schedules)
are inserted for reference purposes only and shall not affect in any way the
meaning, construction or interpretation of this Agreement. Any reference to the
masculine, feminine, or neuter gender shall be a reference to such other gender
as is appropriate. References to the singular shall include the plural and vice
versa.

     12. Counterparts. This Agreement may be executed in two or more
counterparts, and by the different parties hereto in separate counterparts, each
of which when executed shall be deemed to be an original, and all of which, when
taken together, shall constitute one and the same document. This Agreement shall
become effective when one or more counterparts, taken together, shall have been
executed and delivered by all of the parties.

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     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
first written above herein.

                                        PRESCIENT APPLIED INTELLIGENCE, INC.


                                        By:
                                           -------------------------------------
                                           Name:
                                           Title:


                                        SHAREHOLDER:


                                        By:
                                           -------------------------------------
                                           Name:
                                           Title:
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                                   Schedule A
                             Names of Shareholders