Exhibit 10.006  FOURTH
AMENDMENT TO TEN-YEAR INDUSTRIAL NET LEASE AGREEMENT  (Covering
Building 8 Space and Building 3 Space, in Phase I of Seaport Centre)  This Fourth Amendment to
Ten-Year Industrial Net Lease Agreement (Amendment) is entered into, and
dated for reference purposes, as of October 18, 2002 (the Execution Date) by
and between METROPOLITAN LIFE INSURANCE COMPANY, a New York corporation
(Metropolitan), as Landlord (Landlord), and CYGNUS, INC., a Delaware
corporation (Cygnus), as Tenant (Tenant), with reference to the following
facts (Recitals):  A.  Metropolitans predecessor in interest as Landlord (Seaport
Centre Venture Phase I, a California general partnership, herein, the
Venture) and Tenants predecessor in interest as Tenant (Cygnus Research
Corporation, a California corporation) entered into that certain written Lease
dated September 27, 1988 (the Original Lease), for certain premises of
approximately 20,880 square feet of space in Building 8 of Phase I (Building 8
Space), whose current street address remains 701 Galveston Street, Redwood
City, California, all as more particularly described in the Original Lease,
which Original Lease included Rider No. 1 To Seaport Centre Standard Lease and
Exhibits A, A-1, B & C.  B.  The Venture and Tenants predecessor in interest as Tenant at the
time (then, Cygnus Therapeutic Systems, a California corporation) entered into
that certain written First Amendment To Ten-Year Industrial Net Lease Agreement
dated May 15, 1992 (the First Amendment) for certain space in Building 5 of
Phase I (Building 5 Space), and that certain written Second Amendment To
Ten-Year Industrial Net Lease Agreement dated August 8, 1992 (the Second
Amendment) for certain space of approximately 11,158 square feet in Building 3
of Phase I (Building 3 Space), whose current street address remains 501
Chesapeake Street, Redwood City, California.  C.  Landlord and Tenant entered into that certain written Third
Amendment to Ten-Year Industrial Net Lease Agreement dated as of June 8, 1998
(the Third Amendment).  D.  The Original Lease, as amended prior to this Amendment, is
referred to as the Existing Lease. The Existing Premises, prior to this
Amendment, shall mean the Building 8 Space (as defined in the Third
Amendment, approximately 20,880 square feet of space Building 8 of Phase I,
whose current street address remains 701 Galveston Drive, Redwood City,
California) and the Building 3 Space (as defined in the Third Amendment,
approximately 11,158 square feet in Building 3 of Phase I, whose current street
address remains 501 Chesapeake Street, Redwood City, California).  E.  Tenant subleases the Building 8 Space to Ortho-McNeil
(Ortho-McNeil) and desires to surrender the Building 8 Space to Landlord to reduce
Tenants future lease obligations. Landlord and Tenant desire to provide for
(i) Tenants surrender of the Building 8 Space; (ii) continuation of the
Existing Lease as to the remaining Building 3 Space; and (iii) other amendments
of the Existing Lease, in strict accordance with the terms and conditions set
forth herein.  NOW, THEREFORE, in consideration
of the foregoing, the mutual covenants set forth herein and in the Existing
Lease, and other good and valuable consideration, the receipt and adequacy of
which are hereby acknowledged, the parties hereto agree as follows:  Section
1. Scope of Amendment; Defined Terms. Except as expressly provided
in this Amendment, the Existing Lease shall remain in full force and effect.
Should any inconsistency arise between this Amendment and the Existing Lease as
to the specific matters which are the subject of this Amendment, the terms and
conditions of this Amendment shall control. The term Existing Lease defined
above shall refer to the Existing Lease as it existed before giving effect to
the modifications set forth in this Amendment and the term Lease as used
herein and in the Existing Lease shall refer to the Existing Lease as modified
by this Amendment. All capitalized terms used in this Amendment and not defined
herein shall have the meanings set forth in the Existing Lease unless the
context clearly requires otherwise.   Page 1 
    Section 2.               Condition Precedent. This
Amendment and the obligations of each party hereunder are expressly subject to
the condition precedent of the execution by Cygnus and Landlord of a new
written lease with Ortho-McNeil for the Surrender Space (defined below) and
certain additional space satisfactory in all respects in form and substance to
Landlord, in Landlords sole discretion (the Ortho-McNeil Lease). If such
condition precedent is not satisfied or waived in writing by Landlord in its
sole discretion, this Amendment shall be null and void, and of no force or
effect, and the Existing Lease shall remain in full force and effect unmodified
by this Amendment. Landlord shall give Tenant written notice of the
satisfaction or waiver of this condition precedent.  Section 3.               Surrender Space &
Amendments of Existing Lease Thereafter.  (a)           Surrender Space. For purposes of this Amendment, the
Surrender Space means the Building 8 Space.  (b)           Surrender Date. 
On or before 11:59 p.m. on the date (the Surrender Date) which is the
later of: (1) October 15, 2002, or (2) the date Landlord and Tenant have
executed this Agreement, or (3) the date the condition precedent is satisfied
or waived by Landlord (and the actual date of satisfaction of the condition
precedent shall be the operative date for purposes of this determination,
regardless whether it occurs earlier or later than notice from Landlord of such
satisfaction). Tenant shall vacate and deliver to Landlord exclusive possession
of the Surrender Space pursuant to the same provisions and requirements of the
Existing Lease as would apply to surrender of the Premises upon expiration of
the Existing Lease, except that the Surrender Space shall be delivered with
Ortho-McNeil in occupancy and with all real property improvements and systems
servicing the Premises in place, and with all trade fixtures of either Tenant
or Ortho-McNeil in place. Tenant shall deliver to Landlord any plans and
specifications pertaining to the Surrender Space.  (c)           Obligations Until Surrender; Proration.  All of the terms, covenants, agreements and
conditions of the Existing Lease remain in full force and effect with respect
to the Surrender Space through the Surrender Date. Tenant shall continue to pay
all rent and monetary obligations which accrue through and including the
Surrender Date, as such become due and payable under the Existing Lease. As of
11:59 p.m. on the Surrender Date, the surrender of the Surrender Space will be
deemed effective and the monetary obligations with respect to the Surrender
Space shall be prorated, billed and payable in the manner provided in the
Existing Lease, in the same manner as would apply if the term of the Existing
Lease expired on the Surrender Date with respect to the Surrender Space.  (d)           Effect on Existing Lease After Surrender Date.
After the Surrender Date, the Existing Lease shall continue in full force and
effect for the remainder of the term of the Existing Lease upon and subject to
all of the terms and provisions of the Existing Lease, except as amended by
this Amendment, including, without limitation, the following modifications of
the Existing Lease:  (i)  the Surrender Space shall cease to be part of the Premises, and
the Premises shall consist only of the Building 3 Space, and Tenant shall have
no right to possession, use or lease of the Surrender Space or any options or other
rights with respect to the Surrender Space;  (ii) Tenants obligation to pay
monthly base rent with respect to the Surrender Space shall cease, but the base
rent for the Building 3 Space shall remain unaffected by this Amendment, and
accordingly Tenants monthly base rent for the Premises, is changed to the
monthly amounts during the respective periods shown in the following table:  Period (inclusive of dates listed)
  
  Monthly Base Rentday after Surrender Date - 12/10/02
  
  $26,825.6912/11/02 - 12/10/03
  
  $27,625.35   Page 2 
    (iii) Tenant shall no longer be
obligated to pay monthly its proportionate share of Building Operating Expenses
accruing after the Surrender Date with respect to the Surrender Space, but
Tenant shall continue to pay its proportionate share of Building Operating
Expenses accruing after the Surrender Date with respect to the Building 3
Space, which equals twenty-nine percent (29%) as stated in the Third Amendment;  (iv) Tenants proportionate
share of Project Operating Expenses (as defined in the Third Amendment, as the
percentage obtained by dividing the aggregate rentable square footage of the
Premises located in the Project by the total rentable square footage of the Project)
shall change to two and 76/1000 percent (2.076%);  (v) Tenants proportionate share
of Phase Operating Expenses of and attributable to Phase I (as defined in the
Third Amendment, as the percentage obtained by dividing the aggregate rentable
square footage of the Premises located in Phase I by the total rentable square
footage of Phase I) shall change to three and 697/1000 percent (3.697%); and  (vi) the aggregate number of
parking spaces provided for Tenants use is reduced to thirty-four (34).  (e) Holding Over.
Notwithstanding any provision of this Amendment to the contrary, in the event
that Tenant fails timely to vacate and deliver exclusive possession of the
Surrender Space to Landlord by the Surrender Date as required under the
Existing Lease, except as amended by this Amendment, Tenant shall be deemed to
be holding over with respect to the Surrender Space without the express written
consent of Landlord, such possession shall be a tenancy at sufferance and the
provisions of Section 36 of the Original Lease shall apply.  (f) No Release.
Notwithstanding any provision of the foregoing to the contrary, neither this
Amendment nor the acceptance by Landlord of the Surrender Space shall in any
way:  (i) be deemed to excuse or
release Tenant from any obligation or liability with respect to the Surrender
Space (including, without limitation, any obligation or liability under
provisions of the Existing Lease to indemnify, defend and hold harmless
Landlord or other parties, or with respect to any breach or breaches of the
Existing Lease) which obligation or liability (x) first arises on or prior to
the date on which Tenant delivers to Landlord possession of the Surrender Space
or (y) arises out of or is incurred in connection with events or other matters
which took place on or prior to such date, or  (ii) affect any obligation under
the Existing Lease which by its terms is to survive the expiration or sooner
termination of the Existing Lease.  Section
4. Change of Address for Copies of Notices to Landlord. The Foster
City, California address for a copy of all notices to Landlord set forth
Section 14 of the Third Amendment is hereby changed as follows (but the other
address for all notices to Landlord remain unchanged):  Metropolitan
Life Insurance Company 400
South El Camino Real, Suite 800 San
Mateo, CA 94402 Attention:
Assistant Vice President  Section
5. Tenant Estoppel. Tenant hereby confirms and ratifies the
Existing Lease, as amended hereby, and acknowledges that Landlord is not in
default under said Existing Lease as of the date of this Amendment.  Section
6. Time of Essence. Without limiting the generality of any other
provision of the Existing Lease, time is of the essence to each and every term
and condition of this Amendment.   Page 3 
   Section
7. Brokers. Tenant represents that Tenant has dealt with no broker
representing Tenant in connection with this Amendment and that no broker is
representing Tenant in negotiating this Amendment or is entitled to any commission
in connection herewith. Tenant hereby protects, defends, indemnifies and holds
Landlord and its agents and employees harmless from all liabilities arising
from or in connection with any claim of any broker claiming to represent Tenant
in connection with this Amendment. Landlord represents that Cornish and Carey
Commercial (CC) is representing Landlord in connection with this Amendment.
Landlord hereby protects, defends, indemnifies and holds Tenant and its agents
and employees harmless from all liabilities arising from or in connection with
any claim of CC or any other broker claiming to represent Landlord in
connection with this Amendment.  Section
8. Attorneys Fees. Each party to this Amendment shall bear its own
attorneys fees and costs incurred in connection with the discussions
preceding, negotiations for and documentation of this Amendment. In the event
any party brings any suit or other proceeding with respect to the subject
matter or enforcement of this Amendment or the Existing Lease, as amended, the
prevailing party (as determined by the court, agency or other authority before
which such suit or proceeding is commenced) shall, in addition to such other
relief as may be awarded, be entitled to recover attorneys fees, expenses and
costs of investigation as actually incurred, including court costs, expert
witness fees, costs and expenses of investigation, and all attorneys fees,
costs and expenses in any such suit or proceeding (including in any action or
participation in or in connection with any case or proceeding under the
Bankruptcy Code, 11 United States Code Sections 101 et seq., or any successor
statutes, in establishing or enforcing the right to indemnification, in
appellate proceedings, or in connection with the enforcement or collection of
any judgment obtained in any such suit or proceeding).  Section
9. Effect of Headings; Recitals: Exhibits. The titles or headings
of the various parts or sections hereof are intended solely for convenience and
are not intended and shall not be deemed to or in any way be used to modify,
explain or place any construction upon any of the provisions of this Amendment.
Any and all Recitals set forth at the beginning of this Amendment are true and
correct and constitute a part of this Amendment as if they had been set forth
as covenants herein. Exhibits, schedules, plats and riders hereto which are
referred to herein are a part of this Amendment.  Section
10. Entire Agreement; Amendment. This Amendment taken together with
the Existing Lease, together with all exhibits, schedules, riders and addenda
to each, constitutes the full and complete agreement and understanding between
the parties hereto and shall supersede all prior communications,
representations, understandings or agreements, if any, whether oral or written,
concerning the subject matter contained in this Amendment and the Existing
Lease, as so amended, and no provision of the Existing Lease as so amended may
be modified, amended, waived or discharged, in whole or in part, except by a
written instrument executed by all of the parties hereto.  Section
11. Authority. Each party represents and warrants to the other that
it has full authority and power to enter into and perform its obligations under
this Amendment, that the person executing this Amendment is fully empowered to
do so, and that no consent or authorization is necessary from any third party.
Landlord may request that Tenant provide Landlord evidence of Tenants
authority.  Section
12. Counterparts. This Amendment may be executed in duplicates or
counterparts, or both, and such duplicates or counterparts together shall
constitute but one original of the Amendment. Each duplicate and counterpart
shall be equally admissible in evidence, and each original shall fully bind
each party who has executed it.  Section
13. Telecopied Signatures. In order to expedite the transaction
contemplated herein, telecopied signatures may be used in place of original
signatures on this Amendment. All signatories to this Amendment intend to be
bound by such signatures, are aware that the other party or parties will rely
on the telecopied signatures and hereby waive any defenses to the enforcement
of the terms of this Amendment based on the fact that a signature was
telecopied.   Page 4 
    IN WITNESS WHEREOF, the parties
hereto have executed this Amendment as of the date first set forth above.  TENANT: CYGNUS, INC.,a Delaware corporationBy:
  /s/ John C HodgmanPrint Name:
  John C HodgmanTitle:
  Chairman, President & CEOLANDLORD: METROPOLITAN LIFE INSURANCE COMPANY,a New York corporationBy:
  /s/ B Jill FitzgeraldPrint Name:
  B Jill FitzgeraldTitle:
  Assistant Vice President   Page
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