Exhibit 10.14


 


SECOND
AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT


 


This Second Amended
and Restated Executive Employment Agreement (the “Agreement”) is entered into as of September 21, 2015 by and
between Edge Therapeutics, Inc., a Delaware corporation (the “Company”), and R. Loch Macdonald (“Executive”).
This Agreement shall become effective as of the closing of the Company’s initial public offering (the “Effective Date”).


 


W I T N E S S E T H :


 


WHEREAS, the Company
and Executive are parties to that certain Amended and Restated Executive Employment Agreement entered into as of August 12, 2015
(the “Prior Employment Agreement”);


 


WHEREAS, the parties
desire to enter into this Agreement to, among other things, amend and restate the Prior Employment Agreement in its entirety; and


 


WHEREAS, the Company
desires to continue to employ Executive and to enter into this Agreement embodying the terms of such employment, and Executive
desires to enter into this Agreement and to continue such employment, subject to the terms and provisions of this Agreement.


 


NOW, THEREFORE, in
consideration of the promises and mutual covenants contained herein and for other good and valuable consideration, the receipt
and sufficiency of which are mutually acknowledged, the Company and Executive hereby agree as follows:


 


Section 1.               
Definitions.


 


(a)               
“Accrued Obligations” shall mean (i) all accrued but unpaid Base Salary through the Date of Termination,
(ii) any unpaid or unreimbursed business expenses incurred in accordance with Section 6 hereof, (iii) any accrued but unused vacation
time through the Date of Termination, and (iv) any earned but unpaid annual bonus with respect to the year immediately preceding
the year in which the Date of Termination occurs.


 


(b)              
“Base Salary” shall mean the salary provided for in Section 4(a) hereof, as adjusted from time to time.


 


(c)               
“Board” shall mean the Board of Directors of the Company.


 


(d)              
“Confidentiality Agreement” or “Confidentiality and Invention Assignment Agreement”
shall mean the Officer Confidentiality and Invention Agreement executed by Executive on March 6, 2013.


 


(e)               
“Cause” shall mean (i) Executive’s failure, neglect, or refusal to perform in any material respect
Executive’s duties and responsibilities under this Agreement (in each case, except where due to a Disability, sickness or
illness); (ii) any act of Executive that has, or could reasonably be expected to have, the effect of injuring the business of the
Company or its subsidiaries in any material respect; (iii) Executive’s conviction of, or plea of guilty or no contest to:
(x) a felony or (y) any other criminal charge that has, or could be reasonably expected to have, an adverse impact on the performance
of Executive’s duties to the Company or otherwise result in material injury to the reputation or business of the Company
or any of its subsidiaries; (iv) Executive’s commission of an act of fraud or embezzlement against the Company or any of
its subsidiaries; (v) any material violation by Executive of the policies of the Company, including but not limited to those relating
to sexual harassment or business conduct, and those otherwise set forth in the manuals or statements of policy of the Company,
as may be amended from time to time; (vi) Executive’s material violation of federal or state securities laws; (vii) Executive’s
unauthorized use or disclosure of any confidential or proprietary information or trade secrets of the Company, any of its affiliates
or of any other party to whom Executive or the Company or its affiliates owes an obligation of nondisclosure or confidentiality;
or (viii) Executive’s material breach of this Agreement or material breach of the Confidentiality and Invention Assignment
Agreement.






    	 



    	 



    




(f)               
“Code” shall mean the Internal Revenue Code of 1986, as amended, and the rules and regulations promulgated
thereunder.


 


(g)              
“Date of Termination” shall mean the date on which Executive’s employment terminates.


 


(h)              
“Disability” shall mean any physical or mental disability or infirmity of Executive that prevents Executive
from performing his duties with or without a reasonable accommodation for a period of (i) ninety (90) consecutive days or (ii)
one hundred twenty (120) non-consecutive days during any twelve (12) month period. Any question as to the existence, extent, or
potentiality of Executive’s Disability upon which Executive and the Company cannot agree shall be determined by a qualified,
independent physician selected by the Company and approved by Executive (which approval shall not be unreasonably withheld). The
determination of any such physician shall be final and conclusive for all purposes of this Agreement. Executive understands that
he is a “key employee” in connection with any leave qualifying for coverage under the Family and Medical Leave Act
(“FMLA”).


 


(i)                
“Good Reason” shall mean, without Executive’s written consent, (i) a material diminution in Executive’s
title, duties, or responsibilities as set forth in Section 3 hereof; (ii) a material reduction in Base Salary as set forth in Section
4(a) hereof (other than pursuant to a reduction applicable to all similarly situated executives); or (iii) any material breach
of this Agreement by the Company (other than a provision that is covered by clause (i) or (ii)). Executive acknowledges and agrees
that Executive’s exclusive remedy in the event of any material breach of this Agreement by the Company shall be to assert
Good Reason pursuant to the terms and conditions of this Section 1(i) and Section 7(e) hereof. Notwithstanding the foregoing, in
the event that the Company reasonably believes that Executive may have engaged in conduct that could constitute Cause hereunder,
the Company may, in its sole and absolute discretion, suspend Executive’s duties or employment, and in no event shall any
such suspension constitute an event pursuant to which Executive may terminate employment with Good Reason or otherwise constitute
a breach of this Agreement by the Company; provided, that no such suspension shall alter the Company’s obligations
under this Agreement during such period of suspension.


 



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(j)                
“Release of Claims” shall mean a separation agreement in a form acceptable to the Company under which
Executive releases the Company and certain other persons and entities from any and all claims and causes of action and the execution
of which is a condition precedent to Executive’s eligibility for the payments and benefits described in Sections 7(d), 7(e)
and 10.


 


(k)              
“Severance Benefits” shall mean continued payment of Base Salary during the Severance Term, in accordance
with the Company’s regular payroll practices.


 


(l)                
“Severance Term” shall mean the twelve (12) month period, which commences on the first pay day that is
at least thirty-five (35) days after the Date of Termination following termination of Executive’s employment by the Company
without Cause or by Executive for Good Reason.


 


Section 2.               
Acceptance and Term.


 


The Company agrees
to employ Executive on an at-will basis, and Executive agrees to accept such employment and serve the Company, in accordance with
the terms and conditions set forth herein. The term of employment (referred to herein as the “Term”) shall commence
on the Effective Date and shall continue until terminated by either party at any time, subject to the provisions herein.


 


Section 3.               
Position, Duties, and Responsibilities; Place of Performance.


 


(a)               
Position, Duties and Responsibilities. During the Term, Executive shall be engaged to serve as the Chief Scientific
Officer of the Company (together with such other position or positions consistent with Executive’s title or as the Company
shall specify from time to time) and shall have such duties and responsibilities commensurate therewith, and such other duties
as may be assigned and/or prescribed from time to time by Executive’s supervisor and/or the Board. The Executive shall report
to the President and Chief Executive Officer of the Company. Executive will perform business and professional services consistent
with his job title and position within the Company and as reasonably assigned to Executive by the Company’s President and
Chief Executive Officer.


 


(b)               Performance.
Executive shall devote his full business time, attention, skill, and best efforts to the performance of his duties under this
Agreement and shall not engage in any other business or occupation during the Term, including, without limitation, any
activity that (x) conflicts with the business or interests of the Company, (y) interferes with the proper and
efficient performance of Executive’s duties for the Company, or (z) interferes with Executive’s exercise of
judgment in the Company’s best interests. Notwithstanding the foregoing, nothing herein shall preclude Executive from
(i) serving, with the prior written consent of the Board, as a member of the boards of directors or advisory boards (or their
equivalents in the case of a non-corporate entity) of non-competing businesses and charitable organizations, (ii) engaging in
charitable activities and community affairs, (iii) managing Executive’s personal investments and affairs and (iv)
retaining his academic appointment with St Michael’s Hospital and the University of Toronto, or accepting similar
academic appointments in the United States; provided, however, that the activities set out in clauses (i), (ii), (iii)
and (iv) shall be limited by Executive so as not to interfere, individually or in the aggregate, with the performance of
Executive’s duties and responsibilities hereunder. Executive represents that he has provided the Company with a
comprehensive list of all outside professional activities with which he is currently involved or reasonably expects to become
involved. In the event that, during his employment by the Company, the Executive desires to engage in other non-competitive
outside professional activities, not included on such list, Executive will first seek written approval from the President and
Chief Executive Officer and such approval shall not be unreasonably withheld.



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Section 4.               
Compensation.


 


(a)               
Base Salary. During the Term, in exchange for Executive’s satisfactory performance of his duties and responsibilities
Executive will initially be paid a Base Salary at the rate of $375,000 per annum, payable in accordance with the Company’s
regular salary payment schedule and subject to applicable taxes and withholdings. The Base Salary of the Executive for subsequent
years of this Agreement may be increased, decreased, or may stay the same, depending on the Executive’s performance and the
performance of the Company.


 


(b)              
Annual Bonus. In addition to Executive’s Base Salary, during the Term, Executive will be eligible to earn an
annual discretionary performance-based bonus, with a target bonus opportunity equal to 45% of the Base Salary. Performance metrics
with respect to said bonus will be determined by the Board or the compensation committee of the Board. Executive shall be eligible
for said bonus only if Executive is employed on the last day of the performance period. Any earned annual bonus will be paid by
March 15th of the year following the year in which the applicable performance period ends.


 


(c)               
Equity Awards. During the Term, Executive shall be eligible to be granted equity awards by the Company, as determined
by the Board or the compensation committee of the Board. To the extent that the following would not result in a violation of Code
Section 409A, upon the consummation of a Change of Control (as defined below), provided that the Date of Termination has not occurred
earlier, Executive shall be entitled to immediate and full accelerated vesting of all equity awards granted to Executive by the
Company that are outstanding immediately prior to such Change of Control, without regard to the vesting schedule set forth in any
applicable plan or arrangement governing such equity awards (provided that any equity awards that are subject to the satisfaction
of performance goals shall be deemed earned at not less than target performance).


 


Section 5.               
Executive Benefits.


 


During the Term, Executive
shall be offered participation in health insurance and other benefits provided generally to similarly situated executives of the
Company, subject to the terms, conditions and eligibility requirements of the applicable benefit plans (which shall govern). During
the Term, Executive shall be eligible for four weeks’ paid time off in each calendar year, subject to the policies, terms
and conditions of the Company’s paid time off policies (as in effect from time to time), and pro-rated for any partial calendar
year worked. In addition, during the Term, Executive shall be eligible for the same number of holidays as well as any other broad-based
benefits, except those excluded herein, in each case, as are generally allowed to similarly situated executives of the Company
in accordance with the Company policy as in effect from time to time. Nothing contained herein shall be construed to limit the
Company’s ability to amend, suspend, or terminate any benefit plan or policy at any time without providing Executive notice,
and the right to do so is expressly reserved.



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Section 6.               
Reimbursement of Business Expenses.


 


During the Term, the
Company shall reimburse Executive for documented, out-of-pocket business expenses reasonably incurred by Executive in the course
of performing Executive’s duties and responsibilities hereunder, which are consistent with the Company’s policies in
effect from time to time with respect to business expenses, and subject to the Company’s requirements with respect to reporting
of such expenses.


 


Section 7.               
Termination of Employment.


 


(a)               
General. Executive’s employment with the Company shall terminate upon the earliest to occur of: (i) Executive’s
death, (ii) a termination by reason of a Disability, (iii) a termination by the Company with or without Cause, or (iv) a termination
by Executive with or without Good Reason. Notwithstanding anything herein to the contrary, the payment (or commencement of a series
of payments) hereunder of any nonqualified deferred compensation (within the meaning of Section 409A of the Code) upon a termination
of employment shall be delayed until such time as Executive has also undergone a “separation from service” as defined
in Treas. Reg. 1.409A-1(h), at which time such nonqualified deferred compensation (calculated as of the date of Executive’s
termination of employment hereunder) shall be paid (or commence to be paid) to Executive on the schedule set forth in this provision
as if Executive had undergone such termination of employment (under the same circumstances) on the date of Executive’s ultimate
“separation from service.”


 


(b)              
Termination Due to Death or Disability. Executive’s employment under this Agreement shall terminate automatically
upon Executive’s death. Executive’s employment may be terminated by the Company, in its sole discretion, upon the occurrence
of a Disability, with such termination to be effective upon Executive’s receipt of written notice of such termination. In
the event of Executive’s termination as a result of his death or Disability, Executive or Executive’s estate or beneficiaries,
as the case may be, shall be entitled only to the Accrued Obligations, and Executive shall have no further rights to or interest
in any compensation or any other benefits under this Agreement.


 


(c)               
Termination by the Company with Cause.


 


		(i)	The Company may terminate Executive’s employment at any time with Cause, effective upon Executive’s
receipt of written notice of such termination; provided, however, that with respect to any Cause termination relying on clause
(i), (v) or (viii) of the definition of Cause set forth in Section 1(e) hereof, to the extent that such act or acts or failure
or failures to act are curable, Executive shall be given ten (10) days’ written notice by the Company of its intention to
terminate him with Cause, such notice to state the act or acts or failure or failures to act that constitute the grounds on which
the proposed termination with Cause is based, and such termination shall be effective at the expiration of such ten (10) day notice
period unless Executive has fully cured such act or acts or failure or failures to act, to the Company’s complete satisfaction.



 



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		(ii)	In the event that the Company terminates Executive’s employment with Cause, Executive shall
be entitled only to the Accrued Obligations (disregarding, for this purpose, clause (iii) of Section 1(a)). Following such termination
of Executive’s employment with Cause, except as set forth in this Section 7(c)(ii), Executive shall have no further rights
to or interest in any compensation or any other benefits under this Agreement. For the avoidance of doubt, Executive’s sole
and exclusive remedy upon a termination of employment by the Company with Cause shall be receipt of the Accrued Obligations (disregarding,
for this purpose, clause (iii) of Section 1(a)).



 


		(iii)	If Executive is terminated for Cause, he shall not be entitled to compensation for any accrued,
but unused vacation days.



 


(d)              
Termination by the Company without Cause. The Company may terminate Executive’s employment at any time without
Cause, given 60 days’ notice (or pay in lieu thereof). In the event that, during the Term, Executive’s employment is
terminated by the Company without Cause (other than due to death or Disability), he shall be eligible for the Accrued Obligations
and, provided that he fully executes (and does not revoke) the Release of Claims as described in Section 7(g), Executive shall
also be eligible for (i) Severance Benefits and (ii) reimbursement for his (and his eligible dependents’) health care continuation
(COBRA) premiums for 12 months following such termination (provided that (A) such benefits shall not be provided beyond the date
on which Executive obtains comparable coverage from a subsequent employer and (B) such benefits shall not be provided to the extent
that the Company determines that it would result in any fine, penalty or tax on the Company or its subsidiaries for being a discriminatory
benefit) (the “COBRA Benefits”). Notwithstanding the foregoing, the Severance Benefits and the COBRA Benefits
shall immediately terminate, and the Company shall have no further obligations to Executive with respect thereto, and any payments
or benefits that were provided will be reimbursed or repaid promptly by Executive to the Company, in the event that Executive breaches
any provision of the Confidentiality and Invention Assignment Agreement or the Release of Claims. Any such termination, reimbursement
or repayment of Severance Benefits or COBRA Benefits shall have no effect on the Release of Claims or any of Executive’s
post-employment obligations to the Company. Following termination of Executive’s employment by the Company without Cause,
except as set forth in this Section 7(d) or Section 10, Executive shall have no further rights to any compensation or any other
benefits under this Agreement. For the avoidance of doubt, except as provided in Section 10, Executive’s sole and exclusive
remedy upon a termination of employment by the Company without Cause shall be receipt of the Severance Benefits and the COBRA Benefits,
subject to his execution and non-revocation of the Release of Claims, and the Accrued Obligations.


 


(e)               
Termination by Executive with Good Reason. Executive may terminate his employment with Good Reason by providing the
Company ninety (90) days’ written notice setting forth in reasonable specificity the event that constitutes Good Reason,
which written notice, to be effective, must be provided to the Company within thirty (30) days after the occurrence of such event.
During such ninety (90) day notice period, the Company shall have a cure right (if curable), and if not cured within such period,
Executive’s termination will be effective upon the expiration of such cure period, and in the event of such termination during
the Term, except as provided in Section 10, Executive shall be entitled to the same payments and benefits as provided in Section
7(d) hereof for a termination by the Company without Cause, subject to the same conditions on payment and benefits (and forfeiture
and repayment) as described in Section 7(d) hereof. Following such termination of Executive’s employment by Executive with
Good Reason, except as set forth in this Section 7(e) or Section 10, Executive shall have no further rights to any compensation
or any other benefits under this Agreement. For the avoidance of doubt, except as provided in Section 10, Executive’s sole
and exclusive remedy upon a termination of employment with Good Reason shall be receipt of the Severance Benefits and the COBRA
Benefits, subject to his execution and non-revocation of the Release of Claims, and the Accrued Obligations.



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(f)               
Termination by Executive without Good Reason. Executive may terminate his employment without Good Reason by providing
the Company ninety (90) days’ written notice of such termination. In the event of a termination of employment by Executive
under this Section 7(f), Executive shall be entitled only to the Accrued Obligations (disregarding, for this purpose, clause (iii)
of Section 1(a)). In the event of a termination of Executive’s employment under this Section 7(f), the Company may, in its
sole and absolute discretion, by written notice, accelerate the Date of Termination without changing the characterization of such
termination as a termination by Executive without Good Reason (and no severance pay, notice pay or pay in lieu of notice or similar
pay shall be owed to Executive). Following such termination of Executive’s employment by Executive without Good Reason, Executive
shall have no further rights to or interest in any compensation or any other benefits under this Agreement. If Executive terminates
his employment without Good Reason, he shall not be entitled to compensation for any accrued, but unused vacation days. For the
avoidance of doubt, Executive’s sole and exclusive remedy upon a termination of employment by Executive without Good Reason
shall be receipt of the Accrued Obligations (disregarding, for this purpose, clause (iii) of Section 1(a)).


 


(g)              
Release of Claims. Notwithstanding any provision herein to the contrary, the provision of severance benefits pursuant
to subsection (d) or (e) of this Section 7 or Section 10 (other than the Accrued Obligations) shall be conditioned upon Executive’s
execution, delivery to the Company, and non-revocation of the Release of Claims (and the expiration of any revocation period contained
in such Release of Claims), such that the Release of Claims becomes effective, with all revocation periods having expired unexercised,
within sixty (60) days after the Date of Termination. If Executive fails to execute the Release of Claims in such a timely manner,
or timely revokes Executive’s execution of the Release of Claims following its execution, Executive shall not be entitled
to any of the severance benefits under Sections 7(d), 7(e) or 10 (other than the Accrued Obligations). Notwithstanding the foregoing,
if such sixty (60) day period ends in a calendar year after the calendar year in which Executive’s employment terminates,
then, to the extent required by Section 409A of the Code, any payment of any amount or provision of any benefit under Sections
7(d), 7(e) or 10 or otherwise that would have been made during the calendar year in which Executive’s employment terminates
shall instead be withheld and paid on the first payroll date in the calendar year after the calendar year in which Executive’s
employment terminates, after which any remaining severance benefits shall thereafter be provided to Executive according to the
applicable schedule set forth herein as if no such delay had occurred.



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Section 8.               
Confidentiality Agreement; Cooperation.


 


(a)               
Confidentiality Agreement. Executive has entered into the Confidentiality and Invention Assignment Agreement. The
terms and conditions of the Confidentiality Agreement are incorporated herein by reference and the obligations and responsibilities
set forth therein shall survive the termination of Executive’s employment regardless of the reason for the termination.


 


(b)              
Litigation and Regulatory Cooperation. During and after Executive’s employment, Executive shall cooperate fully
with the Company in the defense or prosecution of any claims or actions now in existence or which may be brought in the future
against or on behalf of the Company or any of its subsidiaries which relate to events or occurrences that transpired while the
Company employed Executive, provided that the Executive will not have an obligation under this paragraph with respect to
any claim in which the Executive has filed directly against the Company or related persons or entities or the Company has filed
directly against Executive. The Executive’s full cooperation in connection with such claims or actions shall include, but
not be limited to, being available to meet with counsel to prepare for discovery or trial and to act as a witness on behalf of
the Company or any of its subsidiaries at mutually convenient times. During and after Executive’s employment, Executive also
shall cooperate fully with the Company and its subsidiaries in connection with any investigation or review of any federal, state
or local regulatory authority as any such investigation or review relates to events or occurrences that transpired while Executive
was employed by the Company, provided that Executive will not have any obligation under this paragraph with respect to any
claim in which Executive has filed directly against the Company or related persons or entities or the Company has filed directly
against Executive. The Company shall reimburse Executive for any reasonable out-of-pocket expenses incurred in connection with
Executive’s performance of obligations pursuant to this Section 8(b).


 


Section 9.               
Ownership and Use of Confidential Information.


 


The Executive will
maintain in confidence during and subsequent to the Executive’s employment any information about the Company and its affiliates
which is confidential information or which might reasonably be regarded by the Company as confidential and will not use that information
except for the benefit of the Company. In this regard, the terms and conditions of the Confidentiality and Invention Assignment
Agreement are incorporated herein by reference and the obligations and responsibilities set forth therein shall survive the termination
of Executive’s employment regardless of the reason for the termination.


 


Section 10.           
Termination In Connection With or Following a Change of Control.


 


In the event that,
during the Term, either (x) the Company terminates Executive’s employment with the Company other than for Cause (but not
due to death or Disability) (a) within the sixty (60) day period prior to a Change of Control, or (b) within the twelve (12) month
period after a Change of Control or (y) Executive terminates his employment with the Company for Good Reason within twelve (12)
months after a Change of Control (and pursuant to the notice and cure periods set forth in Section 7(e)), then the Executive shall
receive (i) the Severance Benefits and (ii) the COBRA Benefits, and, to the extent the following will not result in a violation
of Code Section 409A, shall also be entitled to immediate and full accelerated vesting of all equity awards received by Executive
from the Company or its parents that are outstanding as of the effective date of such termination without regard for the vesting
schedule set forth in the terms of any applicable plan or arrangement governing such equity awards (provided that any equity awards
that are subject to the satisfaction of performance goals shall be deemed earned at not less than target performance). Notwithstanding
anything herein to the contrary, the receipt of any severance pay or benefits or acceleration of vesting pursuant to this Section
10 will be subject to Executive signing and not revoking the Release of Claims in accordance with Section 7(g). No severance pursuant
to this Section 10 will be paid or provided unless and until the Release of Claims becomes effective and the revocation period
has expired, and Executive has not exercised his revocation, in accordance with Section 7(g). The receipt of any severance pay
and benefits pursuant to this Section 10 will also be subject to Executive not violating the Confidentiality and Invention Assignment
Agreement, returning all Company property, and complying with the Release of Claims. In the event of Executive’s breach of
the Confidentiality and Invention Assignment Agreement or the Release of Claims, all remaining severance payments and benefits
will immediately cease and all severance payments and benefits that were made will be reimbursed and repaid promptly by Executive
to the Company. In the event that Executive becomes entitled to any payments or benefits under this Section 10, Executive shall
not receive any payments or benefits under Section 7. In addition, upon a termination described in this Section 10, Executive shall
be entitled to receive the Accrued Obligations.



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Section 11.           
Change of Control. For purposes of this Agreement, a “Change of Control” occurs when:


 


		(i)	any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange
Act of 1934, as amended) becomes the “beneficial owner” (as defined in Rule 13d-3 under said Act), directly or indirectly,
of securities of the Company representing 50% or more of the total voting power represented by the Company’s then outstanding
voting securities; provided, however; that sales of equity or debt securities to investors primarily for capital-raising
purposes shall in no event be deemed a Change of Control;



 


		(ii)	the date of the consummation of a merger or consolidation of the Company with any other corporation
or business entity that has been approved by the stockholders of the Company, other than a merger or consolidation which would
result in the holders of voting securities of the Company outstanding immediately prior thereto continuing to hold, directly or
indirectly, more than fifty percent (50%) of the total voting power represented by the voting securities of the Company or such
surviving entity outstanding immediately after such merger or consolidation;



 


		(iii)	the stockholders of the Company approve a plan of complete liquidation of the Company; or



 



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		(iv)	there is a consummation of the sale or disposition by the Company of all or substantially all of
the Company’s assets.



 


Section 12.           
Section 409A. This Agreement is intended to comply with, or be exempt from, Code Section 409A (to the extent applicable)
and the parties hereto agree to interpret this Agreement in the least restrictive manner consistent therewith. Without limiting
the generality of the foregoing, severance pay pursuant to Sections 7(d) or (e) or Section 10 constitute separate payments for
purposes of Section 1.409A-2(b)(2) of the Treasury Regulations and thus, to the extent of payments made from the date of termination
of Executive’s employment through March 15 of the calendar year following such termination, such payments are intended to
constitute “short-term deferral” under Section 1.409A-1(b)(4) of the Treasury Regulations. To the extent that severance
payments or benefits are made following said March 15, they are intended to be payable upon an “involuntary separation from
service” pursuant to Section 1.409A-1(b)(9)(iii) of the Treasury Regulations, to the maximum extent permitted by said provision.
Notwithstanding any other provisions of this Agreement to the contrary, if Executive is a “specified employee” within
the meaning of Code Section 409A and the regulations issued thereunder, and a payment or benefit provided for in this Agreement
or otherwise would be subject to additional tax under Code Section 409A if such payment or benefit is paid within six (6) months
after Executive’s “separation from service” (within the meaning of Code Section 409A), then such payment or benefit
shall not be paid (or commence) during the six-month period immediately following Executive’s separation from service except
as provided in the immediately following sentence. In such an event, any payments or benefits that would otherwise have been made
or provided during such six-month period and which would have incurred such additional tax under Code Section 409A shall instead
be paid to Executive in a lump-sum cash payment on the earlier of (i) the first regular payroll date of the seventh month following
Executive’s separation from service or (ii) the 10th business day following Executive’s death (but not earlier than
such payments otherwise would have been made). In addition, no reimbursement or in-kind benefit shall be subject to liquidation
or exchange for another benefit and the amount available for reimbursement, or in-kind benefits provided, during any calendar year
shall not affect the amount available for reimbursement, or in-kind benefits to be provided, in a subsequent calendar year. Any
reimbursement to which Executive is entitled hereunder shall be made no later than the last day of the calendar year following
the calendar year in which such expenses were incurred. Notwithstanding anything herein to the contrary, neither the Company nor
any of its affiliates shall have any liability to Executive or to any other person or entity if the payments and benefits provided
in this Agreement that are intended to be exempt from or compliant with Code Section 409A are not so exempt or compliant.


 


Section 13.           
Parachute Payment. In the event that (i) Executive becomes entitled to any payments or benefits hereunder or otherwise
from the Company or any of its affiliates which constitute a “parachute payment” as defined in Code Section 280G (the
“Total Payments”) and (ii) Executive is subject to an excise tax imposed under Code Section 4999 (the “Excise
Tax”), then, if it would be economically advantageous for Executive, the Total Payments shall be reduced by an amount
(including zero) that results in the receipt by Executive on an after tax basis (including the applicable federal, state and local
income taxes, and the Excise Tax) of the greatest Total Payments, notwithstanding that some or all of the portion of the Total
Payments may be subject to the Excise Tax. Any such reduction in payments and benefits shall be applied first against the latest
scheduled cash payments; then current cash payments; then any equity or equity derivatives that are included under Code Section
280G at full value rather than accelerated value with the highest value reduced first; then other non-cash or non-equity based
benefits will be reduced (in the order of latest scheduled payments and benefits to earliest scheduled payments); and finally,
any equity or equity derivatives included under Code Section 280G at an accelerated value (and not at full value) shall be reduced
with the highest value reduced first (as such values are determined under Treasury Regulation Section 1.280G-1, Q&A 24). All
calculations hereunder shall be performed by a nationally recognized independent accounting firm selected by the Company, with
the full cost of such firm being borne by the Company. Any determinations made by such firm shall be final and binding on Executive
and the Company.






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Section 14.           
Clawback. Notwithstanding anything herein to the contrary, any equity-based or incentive compensation provided to
Executive, including any bonuses or equity awards provided pursuant to Sections 4(b) or 4(c) of this Agreement, shall be subject
to any “clawback” required by law or by any national securities exchange on which the Company’s securities are
listed, or to any clawback or recoupment policy otherwise adopted by the Company from time to time. For the avoidance of doubt,
notwithstanding anything herein to the contrary, in no event shall any reduction in the amount of compensation ultimately provided
to or retained by Executive on account of this Section 14 constitute an event pursuant to which Executive may terminate employment
for Good Reason or otherwise constitute a breach of this Agreement by the Company.


 


Section 15.           
No Conflict with Existing Obligations. Executive represents that his performance of all the terms of this Agreement
and his duties as an executive of the Company do not and will not breach any agreement or obligation of any kind made prior to
Executive’s employment by the Company, including agreements or obligations Executive may have with prior employers or entities
for which Executive has provided services. Executive has not entered into, and Executive agrees that Executive will not enter into,
any agreement or obligation, either written or oral, in conflict herewith.


 


Section 16.           
Assignment. This Agreement for personal services shall not be assigned by Executive. This Agreement will be binding
upon and inure to the benefit of any successor of the Company. Any such successor of the Company will be deemed substituted for
the Company under the terms of this Agreement for all purposes. For this purpose, “successor” means any person, firm,
corporation or other business entity which at any time, whether by purchase, merger or otherwise, directly or indirectly acquires
all or substantially all of the assets or business of the Company.


 


Section 17.           
Arbitration; WAIVER OF JURY TRIAL. In consideration of Executive’s employment with the Company, the
Company and Executive agree that any and all controversies, claims, or disputes with anyone (including the Company, Executive and
any executive, officer, director, shareholder or benefit plan of the Company in their capacity as such or otherwise) arising out
of, relating to, or resulting from Executive’s employment with the Company or the termination of Executive’s employment
with the Company, including any relating to this Agreement, will be subject to binding arbitration. Disputes which Executive hereby
agrees to arbitrate, AND THEREBY AGREES TO WAIVE ANY RIGHT TO A TRIAL BY JURY, include, but are not limited to, any
statutory claims under state or federal law, including, but not limited to, claims under Title VII of the Civil Rights Act of 1964,
the Americans with Disabilities Act of 1990, the Age Discrimination in Employment Act of 1967, the Older Workers Benefit Protection
Act, the Worker Adjustment and Retraining Notification Act, the Family and Medical Leave Act, the New Jersey Law Against Discrimination,
the New Jersey Conscientious Executive Protection Act, the New Jersey Family Leave Act, and any other federal, state or local discrimination,
retaliation or wrongful termination claims or other statutory or common law claims. Executive further understands that this Agreement
to arbitrate also applies to any disputes that the Company may have with Executive. Executive agrees that any arbitration will
be administered by the American Arbitration Association (“AAA”) and that a single neutral arbitrator will be selected
in a manner consistent with its National Rules for the Resolution of Employment Disputes (the “Rules”). All arbitration
fees and costs shall be shared equally by the parties, but the parties shall be responsible for payment of their own attorneys’
fees. Executive agrees that the arbitrator will administer and conduct any arbitration in a manner consistent with the Rules. Notwithstanding
the foregoing, nothing herein shall limit or alter the Company’s right to seek injunctive or other equitable relief in any
court of competent jurisdiction under (and as described in) the Confidentiality Agreement.



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Section 18.           
Voluntary Nature of Agreement. Executive acknowledges and agrees that Executive is executing this Agreement voluntarily
and without any duress or undue influence by the Company or anyone else. Executive further acknowledges and agrees that Executive
has carefully read this Agreement and that Executive has asked any questions needed for Executive to understand the terms, consequences
and binding effect of this Agreement and fully understands it, including that Executive is WAIVING EXECUTIVE’S RIGHT
TO A JURY TRIAL. Finally, Executive agrees that Executive has been provided an opportunity to seek the advice of an attorney
of Executive’s choice before signing this Agreement.


 


Section 19.           
Other.


 


(a)               
Waiver of Breach. The waiver by the Company of a breach by Executive of any provision of this Agreement or the Confidentiality
and Invention Assignment Agreement shall not operate or be construed as a waiver of the Company’s rights with respect to
any subsequent breach by the Executive.


 


(b)              
Governing Law and Forum. This Agreement shall be construed and administered in accordance with the laws of the State
of New Jersey, exclusive of its conflict of laws rules, and the parties hereto agree and stipulate that this Agreement shall be
deemed to have been entered into in the State of New Jersey, regardless of where it was negotiated, implemented and/or executed.


 


(c)               
Severability. In the event that any one or more of the provisions of this Agreement shall for any reason be held
to be invalid, illegal, or unenforceable, the remaining provisions of this Agreement shall be unimpaired, and shall continue in
full force and effect.


 


(d)              
Construction. This Agreement shall be interpreted in accordance with its plain meaning, and the rule that ambiguities
shall be construed against the drafter of the document shall not apply in connection with the construction or interpretation hereof.
The parties expressly agree that the principle of contract interpretation that ambiguities are construed against the drafting party
shall not apply.



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(e)               
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed to be an
original, but all of which together shall constitute one and the same instrument.


 


(f)               
Entire Agreement. This Agreement and the Confidentiality and Invention Assignment Agreement contain the entire agreement
and understanding of the parties with respect to the subject matter hereof, and supersede all prior or contemporaneous promises,
understandings, or agreements, whether written or oral (including, without limitation, the Prior Employment Agreement) relating
to the subject matter hereof. This Agreement may not be changed orally, but only by an agreement in writing, signed by both parties.


 


(g)              
Survivorship. The provisions of Sections 1, 7(d), 7(e) and 7(g) and Sections 8 through 19 shall survive the termination
of Executive’s employment with the Company and this Agreement.


 


[Signatures on following
page]



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IN WITNESS WHEREOF,
each of the parties has executed this Agreement, in the case of the Company by its duly authorized officer, as of the day and year
first above written.


 


	 	EDGE THERAPEUTICS, INC.
	 	 
	 	 
	Date: September 21, 2015	/s/ Brian A. Leuthner
	 	By:	Brian A. Leuthner
	 	Title:	President and Chief Executive Officer
	 	 
	 	 
	 	EXECUTIVE
	 	 
	 	 
	Date: September 21, 2015	/s/ R. Loch Macdonald
	 	R. Loch Macdonald








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