Ethalfluralin Dietary Exposu re and Risk Assessment DP Number: 432016



### UNIT E D STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D. C. 20460



### M E MORANDUM DATE: 18-MAR-20 1 6 OFFICE O F C H E MI CA L SAF E TY AN D POLLUT I ON PRE VEN T I O N



### SU BJECT: Ethalflur a lin: Acute, Non-Cancer Chronic, and Cancer D ie tary (Foo d and Drinking Water) Exposure and Risk Assessments to Support Registration Re v iew. PC Code: I 131 0 I DP B a r co d e: 0432016 D ec i s ion No.: 510535 Re g i s tr a ti o n No.: NA P e tition No.: NA R eg ul atory Action : Registration Review Ri s k Assessment T y p e: Dietary Exposure Case No.: 2260 TXR No.: NA CAS No.: 55283-68-6 MRIDNo.: NA 40CFR: § 1 80.4 16**~** 

### FROM: Juli e 

### L. Van Alstine, MPH , E n v ironmenta l H ealth Scient i st""" \ 

# v.,A_u

# ~**~** Ri sk Assessment Branch 6 (RAB6)/ H ea lth Effects Di visio n ( H i D ; 7509P) 

### THROUGH: Thurs ton G. Morton, Chemist

# V~~~ J e nnif er R. Tyler, Chemist

### ~**~r** Dietary Expos ure Science Advtsory Counc il (DESAC) H E D (7509 P) And Donn a S. Davis, Branch Chief RAB6/ HED (7509 P ) 

### TO: Kelly Ballard , Chem ic al R eview Manager Tom Moriarty , Team Leader Ne il A nd erson, Branch Chief Reg i stra tion Division (RD; 7505 P) 

### Exec uti ve Su mm ary Acute, chronic non-cancer, an d chronic cancer d ietary (food and drinkin g water) ex posure and risk assessments were cond u cted using the Dietary Exposure -Ev a luation Model softwa re with the Food Commodity I ntake Database ( D EEM-FC ID ) Version 3.18, wh ich uses food consumption data from the U.S. Department of Agriculture's (US DA 's) National He a lth and Nutriti on
Page 1 of25Etha lnuralin Di etary Exposure and Risk Assessment DP Number: 432016


### Examinati on Survey, What We Eat in Ame ri ca, (NHANES / WWE l A) from 2003 through 2008
. The ana l yses wer e perfo rmed to support Registration Rev iew of th e he rbicide ethaltl ur alin, 

### [N
ethy i -N-(2-methy l- 2-p ropeny l) -2 ,6 -dinitro-4- ( trifluorom e th y l)-benze n ami n e]. Acute Die tary Ex po su re Results and Characte ri zat ion An acute dietary e ndpo in t ( i .e., single dose endpoint) for ri sk assessmen t was not identified in the toxicity d atabase for the ge n e ra l U .S. population ; however , a n e ndpo int was selected for fema les 1 3-49 year s o ld and an unrefined acu t e dietary (food and drinking water) assess m e nt was comple t ed for this population s ub g roup. The acu t e assessment u sed tolerance-level res idu es and assu m ed I 00 % c r o p tr eate d (CT)
. A m ode led es tim ated drinkin g wate r concentration (E DW C) of 0.02612 ppm was included directl y in the di e tar y a n a lys is. The ac ute di etary ex po s ure and ri sk es t imate fo r fe m a les 13-49 years o l d i s < 1 % of the acute popu lation-adj u ste d do se (aPAD) a nd is below H E D 's leve l of concern (LOC). C hr o ni c Die tar y Ex p os ure Re s ult s and Characterization An unr e fin ed c hro nic no n-cancer dietary ( f ood a nd drinking water) assessmen t fo r ethal tlur alin was a lso co n duc ted that u se d tolerance-level residues and assumed I 00% CT. A modeled E DW C of 0.00057 ppm was includ ed directly in the di e tary analysis. The chronic dietary expos ure and ri sk est im ates are < l % ofthe c h ron ic p o pulati on -adju s ted dose (c P A D ) for a ll populati o n s ub g roups and are below HE D ' s LOC. The m os t hi g hl y expose d popu lation s ub g roup was ch ildren I to 2 years old
. Cancer Dietary Ex po s ure Results and Cha racterization E thalfluralin is cla ss ifi ed as a possible human carcinogen wi th a cancer potency facto r (Q I *)of 8
. 9 x I

# o· 2 

### ( m g/ k g/day)" 1

. 

### A r efine d ethaltlur al in c hro ni c cancer di e ta ry (food a nd drinkin g water) a n a l ysis was co ndu c ted u s in g th e field tri al 

### Y2 lowest leve l of method va li dation ( LLMV ) va lue for a ll potato com moditie s, monitoring data ge ne rate d by USD/\ 's Pesticide Data Pro g ram ( PDP ), to le ra nce -l eve l res idues , and av e ra ge pe rcent crop trea ted ( PCT) data from the Bio logica l and Economic A n a lys i s Divi sio n (BEAD). A mod e led E DW C of0.00 0 36 ppm was includ e d directly in th e dietary ana lys is. Th e mo st hi g hly exposed ad u lt population s ub g ro up s were adults 20-49 yea rs o ld a nd females 13

- 49 years old , with ca nce r di e ta ry (food a nd drinking water) ri sk est im a t es of 8.4x 1 

# o- 7 • 

### Drinkin g wate r was a driver in th e cance r di e tary assess m en t. I. Intr o du c ti o n 

### Di etary r isk assessme n t in corpo r ate s both exposu re and toxicity o f a given pesticide. Fo r acute and c hroni c assessments, the ri sk is expressed as a percent age of a maximum acceptable dose ( i. e. , th e dose that HED h as concluded w i ll result in no unreasonab l e adverse health effec t s). Th is dose is refe rred to as the population-adju s ted dose (PAD). T he PAD i s equiva le nt to the point of d epartur e ( P OD , N O AE L , LO AEL, e.g.) di vided b y the require d uncertain ty or safety factors
.

Page 2 o f 25Ethalfluralin Dietary Exposure and Ri sk Assess ment DP Number: 432016


### For acute and non-cancer chronic exposures , HED i s concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chron ic ri sk assessments in more detai l are available on the EPA/pesticide s web site : "Available Inf ormatio n on Assess in g Exposu re from Pesticides , A User's Guide, " 2 1-J UN-2000, web link: http: //www.regulations.gov/# !documentD eta ii :D = EPA-HQ-OP P- 2007-0780-0001; o r see SOP 99.6 (20

- AUG-1999). The m ost recent dietary risk assessment for ethalfluralin was conducted by C. Swa t tz (02

-NOV

2007; D333868) 

### II. Residue Information Residues of Concern: The resid ue of concern in crops, for purpos es of tol e ran ce enforcement and risk assessment , is etha lfluralin only. The res idu e of concern in drinking water for purposes of ri sk assessment is etha l fluralin only. 

### Established Toleran ces: T ole rances for residues of ethalfluralin are established at 0.05 ppm under 40 CFR 

### § 180.41 6 in / on several crops. There are no registered tolerances for residues in livestock commodities (40 CFR 

### § 180.6 (a)(3)). 

### Residues Used in th e Assessments: Attachmen t I s ummarizes the residu e val ues that were used in the acute, non-cancer ch ron ic, and chronic assessments. The acute and chro nic assessments were unrefined and assumed tolerance-level re s idues (0.05 ppm) and I 00% CT for all commod ities. The cancer assessment was refined and us ed the field tria l 

### !h LLMV va l ue for all potato commodities (0.025 ppm), PCT and PDP data for various commod itie s, and tolerance-level residues for all rema i ning commodit ies. The 

### !h LLMV value was used for potatoes since all field trial residues were b e low the LLMV of 0.05 ppm. A lthough PDP data a rc ava il able for potatoes that indicate that there were no detectable residues (2008 , 2009; N = 11 60; average 

### !h LOD value = 0.00 l ppm), the data were not used s inc e the samples were take n nea r th e tim e of the potato use registration and may not reflect current use pattern s . PDP was specifically designed for risk assessment; analysts prepare samples in a manner similar to t y pical consumer practices , suc h as washing , coring/p itt i ng , and/ or p eeli ng. The PDP samp les are collected at large-scale distribution cen ters, just prior to sa le in grocery stores, and are more likely to reflect " dinner plate" residues. PDP data were used in the cancer assessment for the following commodities: soybean grain (20 II ; N = 300); soy infant formula (2013; N= l7 9); ca ru1ed black bean (20 I 0; N = 367); canned kidney bean (2008, 2009 ; N = 372); canned pinto bean (2009; N = 372); garbanzo bean (2009, 2010; N = 372); can ta loupe (2003 , 2004; 2005; N = l486); watermelon (2010; N = 371) ; cucumber (2009, 2010; N=1474); summer squash (2012, 2013; N = 895) ; winter squash (20 11 , 2012; 2013 ; N = Il15) ; and peanut butter (2006; N = 719). PDP did not detect residues ofetha lfluralin in any ofthe monitored commodit ies ; th erefo r e, the cancer assess ment used the average 

### !h LOD va lu e for th ese commodities as a po in t estimate. The ave rage half LOD value was calculated for each year of PDP data usin g a Statistical Analys is Sys tem (SAS) program. A n average of these val ue s was then calculated for the years of data of

Pa ge 3 of25

### Ethal flu rat in Dietary Exposure and Risk Assessment DP Number: 432016


### interest and incorporated in to the assessment. The cantaloupe data were tran s lated to honeydew melon. The rema inin g commodities used tolerance-level residues. PDP also monitored pesticide residues in catfish in 2008, 2009, and 20 l 0 and in salmo n in 20 1 3. ln general , pesticide residues would not be expec t ed to be found in fi s h unl ess the pesticide bioaccumulates or has an aquatic use. To determine whether or not residues are present in fish , HED now routinely checks PDP monitoring data regardless of the pesticide ' s uses and physicochemical properties. Residues of ethalfluralin were not detected in the 2008, 2009, and 20 I 0 catfish samples o r in the 2013 sa lm on samples. As a result , residue s in fish we re not in cluded in the assessment. 

### Processing Facto r s: The acute and chronic asse ss ments use the D EEM default processing factor of 1.89x for peanut butter. The processing factor was set to 1 x for peanut butter for the cancer assessmen t s inc e PDP data were used for peanut butter and these data already reflect the effects of processing on ethalfluralin residues. For the acute, non - cancer chronic, and cancer assessments, the DEEM default processing factor of 6.5x was used for dry potatoes (granules and flour). 

### Ul. Percent Crop Treated BEAD provided a Sc ree n ing

- Level Usage Analysis (SLUA) memorandum entitl ed, " Screening Level Usage Analysis (SLUA) Rep011 for Ethalflu ralin (PC Code # 113101 ), in S upport of Draft Ri sk Assessment for Registration Revi ew" (Memo, L. Yohannes, 17 -JUN-2015). The acute and chronic assessments u sed I 00% CT assumptions for a ll commodities. The cancer assessment incorporated average PC T data for the following commodities: canola/rapeseed ( <2.5%); cantaloupe (5%); cucumber (50%); peanut (25%); potato (< 1 %); pumpkin (30%); squash (30%); s unflower (10%); and watermelon (20%). The remaining commodities in the cancer assessment assumed 1 00 % CT. IV. 

### Drinking Water Data The residue of concern for risk assessment in drinking water is ethalfluralin. The drinking water residues used in the dietary ri sk assessment were provided by EFED in the following memorandwn: " Ethalfluralin Drinking Water Assessment to Support Regi s tration Review ( DP Barcode 0429863 ; PC Code 113101) " (M. Barrett , 24-FEB-2016). Ti er 2 EDWCs for etha1 flur alin were provided by EFED using the Surface Water Concentration Calculator (SWCC) and the Pesticide Root Zo ne Model for GroundWate r (PRZM -GW ) model s. The surface wate r EDWCs were much higher the groundwater EDWCs, which reflects the low leaching potential for the s trongly adsorbed ethalfluralin molecule. The surface water EDWCs were used in the acute , chronic, and cancer dietary (food and d rinking water) assessments. The acu te EDWCs were modeled using the FL cuc umber scena ri o and the chronic and cancer EDWCs were modeled using the MS corn scenario as a surrogate for soybeans
.

Page 4 of25Etha lnur a lin Dietary Expos ure and Risk Assessment DP Number; 432016
Tabl e 1. Max imum Es t im ated Drin kin g Water Concen t rat ions f o r Groundwater an d Surface Water So urces from the Use of Et ha lflura lin
. DR I NKJNC WAT ER SCENAR IO (USE) (ra te mode led p e r MAX IMUM ESTIMATE D DRINKING SOURCE WATER CONCENTRATION (E DWC) (MODEL year) ( ppb) USED) Groundwater WI sand (I.7 lb a.i applied Ix per year) Acute 0.000437 1 (PRZ M-GW ) WI sa nd (1.7 lb a. i. ) Chronic 0.000437 1 Acute : Cucurbits ( F L Cucumber sce nario ; Acute 26. 1 maximum si ngle a nd seasona l app li cat ion Surface wa ter rate of I
.7 lb a ilA applied annually)) Chro ni c (a nnual ) 0.5 7 (SWCC) C h ron i c : Soybeans (MS corn scenario used as a su rrogate for soybeans; ma x imum s in g le Chroni c / Can ce r (3 0 + and seas onal applicatio n rate of 1. 3 1 lb ai /A yea r s) 0.36 applied annually) 1 Ba sed o n a I00-year s unul at1 o n w1th max 1mum rat e app li ed eve ry yea r. For th e s tand ard 30-year s 1mul at1on th e max imum acu t e concent rati o n was 0.000437 ppb with th e W I sand sce nar i o. S in ce a "breakth rou g h" time was not es tabli s hed ( th e movement of low- l eve l residues into th e aquifer was t oo s l ow eve n with I 00

- year si mulation s) th e chro ni c value was conservatively set to the same as the acute exposure value. 

### V. DEEM

- FC ID P r og ram a nd Co n s ump tio n Information Ethaltlurali n ac ute , non-cancer chronic, and cancer exposure assessments we re co nducted u s in g DEEM-FC IO , Vers ion 3. 18 , whic h incorporate s co n sumptio n data from US D A's N H ANES / WWE IA from 2003 through 2008. The data are based on th e reported consumption of more than 20,000 in div iduals over two non - consecu ti ve s urvey day s . Foods " as consumed " (e
. g., app le pie) a re lin ke d to EPA -defin ed food commoditie s (e.g., app les, peeled fruit- cooked; fresh or N / S; baked; o r wheat fl o ur- cooked; fresh o r N / S, baked) u s in g publicly available recip e tran s la ti on fil es developed j oi ntly by US D NA RS a nd E PA
. For chronic exposure assessment , consu mpti on data a r e ave ra ge d f o r th e e ntire U.S. p o pul at io n and within p o pulation s ubgroup s. However , for ac ute expos ure assessment , consumpt ion dat a a re r e t a in e d as individual co n s umpti o n eve nt s. Ba se d on ana lysis of the 2003-2008 WW E JA co n sumption data , which took int o account di e tar y patterns and survey res pondent s, HED concl ud e d that it is most app r o pri ate to r e port ri s k for the fo ll owing population s ubgro up s: the ge ne ral U.S. popu lation, a ll inf a nt s ( < 1 year o ld ), children 1-2 , chi ldre n 3-5 , c hildren 6- 1 2, yo uth 13-19 , adults 20

- 49, fe m a les 1 3-49, a nd ad ult s 50-99 ye ar s old. For an ac ut e exposure assess m e nt , individual o ne-day food co n s umption d ata are u sed on an individua l- by-individua l basis. The reported consumption amo unt s of each food item can be mu lti plied by a re s idue point estimate and summed to ob t ain a tota l da il y pestic id e expos ure for a deterministic expos ure assessment, or " matched " in multipl e random pa ir ings w ith resi du e values and then su mmed in a probabilistic assessment. The re s ulting dis tri bution of expos ures i s expressed as a percentage of the a P AD on both a u se r ( i. e. , o n ly tho se w h o rep o rted eatin g relevant commod iti es / food fo rm s) and a per-capita ( i. e., tho se w h o reported eat in g the rele va nt commodi ti es as we ll as those who did n o t) basis. In accordance with HED policy , per capita expos ure a nd ri s k are reported for an alyses performed at all leve ls of refi ne m e nt. However, for deter mini s ti c assess m e nt s, any s i g nifi cant differ e nc es in u se r vs. per cap it a exposure and risk are s pecifically id e ntifi ed and noted in the ri s k assessment.

Page 5 of25E thal flural in Dietary Exposure and R isk Assessmen t DP Number: 432016



### Fo r a chron ic dietary exposure assessmen t , an es timate of the re s idu e level in eac h food or foodform (e.g., orange o r o range j ui ce) on th e f oo d commod ity residue li s t is multipli e d by the ave rage dail y con s u mption est imate for that food / foo d for m to produ ce a res idu e intake est im ate. T he resultin g re s idu e in ta k e es timate fo r eac h food / food form is s umm ed w ith th e re s idue int ake es timates fo r all o th e r fo o d/ food forms on th e commodity res idu e li s t to a rri ve at th e tota l ave r age estimated exposu r e. Ex posure i s exp ressed in m g/kg bod y we ig ht / day and as a percen t of the cP AD. Th is proced ure is perfom1 ed fo r each population subgroup. 

### VI. Toxicologica l Information The toxicolog ical databa se for e th a l tluralin is complete a nd a dequ ate for ri sk assess ment. Th e d oses and endpo int s se lec ted for dietary ex p osu r e and ri sk assessme nt for e th a lflu ralin are s h own be low in Table 2. Th ese e ndpoint s ha ve been co n fi rm e d by the ri sk assess m e nt team as a ppropriate for the curren t ri s k assess men t.

Table 2. Et h a lfl u ralin- S u mm ary of Tox i cologica l Do ses and Endpoints for Usc in Dietar y Hum a n H ealt h Ri s k Assess me nts . Exposure Point of U ncertainty / Population Adj us ted Study and Toxicological Effects Dose for Ri sk Sce nario Departure FQPA SFs Assess ment Acute Di etary (Ge ne ra l P

op ulation , A s in g l e do se effec t r e levant to th e ge nera l US population in cludi ng inf an ts and childre n was not including identified in th e toxicity studies co ndu c t

ed with e thalflura lin
. Inf ants an d Children) R abbi t Dev. Toxicity Study M IRD: 00 129057.00250596 Acute Diet ary UFA = l Ox aRfD = 0.75 (Fema l es 13-49 NOAEL = 75 UFH = l Ox mglk g/day yea r s o f age) mg/kg/day FQPA S F = a PAD 

## = 0.75 D eve lo pm e nta l LOAEL = 1 50 l x m glk g/d ay mg/kg/day based on in creased numb er of reso rpti ons and in c r eased s te rn a l and cranial vari ati ons Dog, Chronic Oral Toxicity Study MIRD: 0015337 1. 92062014 UF A= l Ox cRfD 

## = 0.04 LOAEL = 20 m glkg/day ba sed on Chron ic Dietary NOA EL 

## = 4 UF11 = lOx mglkg/day increase d urinary bilirubin , (A ll mg/ kg/day FQ P A SF = cPAD = 0.04 vari ation s in erythroc yte Pop ulation s) lx m g/

kg/day m o rph o logy, incre ase d thromb ocy te cou nt , a nd increased e rythroid se r ies of the bon e marrow. Cancer (o ral , E thalflura l in ha s been classified as a possible human Rat 2

- year ch ronic /carcinogenicity d e nnal , carcinogen (Gro up C) based on increased mammary gland s tud y fibro-ad eno mas & combined adenomas/fibro-adenomas in inhalation ) female rats. Q 1 

### * 

## = 8.9 x 10 · 2 (mg/kg/day)" 1 MIRD:00094776,92062013

Page 6 of25E tha lfl ura I in Di etary Ex p os ure and Ri sk Assess me nt DP Numb er: 432 016
Point of Departure ( PO D)= A da ta po int o r an es tim ated po int th a t is der ived fro m obse r ve d d ose-r es p onse d ata a nd used to mark the beg in ni ng of ex t ra po la ti o n t o de t e rmin e ri sk assoc iat ed w ith lowe r en vi ro nm e ntall y r e l

eva nt hum a n exposures. NOAEL = no observed adve rse e ff ec t level. LOAEL = lowes t obse rved ad verse effec t leve l. UF = uncertainty factor. UFA = extrapo lati o n f r o m ani m al t o hu man ( in terspecies). UF H = po te nti a l variation in sensitivity among membe r s of the human pop u lat io n (i ntraspec ies). FQ P A SF = FQ P A Sa f e t

y Facto r . P A D = population adjus t ed dose (a = acute, c = chronic). 

### VII. Re s ults / Di sc u ss ion As s t a te d above, for a cute and chronic a ssess m e nt s, HED i s co n ce rn e d wh e n di e tary risk exce e d s 100% of th e PA D. The D E EM -F C ID anal yses es timate th e di e t ar y e xpo s ure ofth e U .S
. p o pul a ti o n a nd v ari o u s popu lation subgroup s . Table 3 s umm a ri zes es timated acute die t ary e xp os ure a nd ri s k for f e male s 13-49 years o ld ; c hronic non-c a nc e r ri s k for the genera l U
. S. p o pulati o n , a ll infant s ( < 1 year old) , children 1 -2 , c hil dr e n 3-5 , ch ildren 6-12 , yo uth 13-19 , f e m a les 1 3 -49 , a du lt s 2 0

- 49 , and adults 50

- 99 year s; and can ce r ri s k for th e general U
. S. p o pul a ti o n o nl y, p e r H E D polic y. The re s ultin g a cute a nd non- can ce r c h ron ic food and dri nking wa te r e xp os ure es tim a t es we r e n o t of c o ncern to H E D (5 1 

### 00 % PAD ) . Fo r th e cancer assess m e nt , the m os t hi g hl y e xp os ed adult p o pul at i o n s ub g r o up s w e r e a dult s 20

- 49 years old and fe m a l es 1 3 -4 9 yea rs o ld , w ith cancer di e t ary (fo od a nd drin k in g wa te r) ri s k es timate s of 8.4 x I 

# o- 7

. T ab le 3. Su mm a r y o f Di e t ary (Food a nd Drinkin g W a ter) Ex p os ure a nd Ri sk Estimates for Etba lfluralin
. Ac ut e Di e t ary Chro ni c Di etary 1 Cance r-2 (9 5 'h Percent ile) Pop ul atio n S ubgroup Dietary Di etary Di e t ary Ex p os ure %aPAD Ex p os ure %c PAD Exp osure Ri s k (mglkg/day) (m glkg/day) (mglkg/day) General U.S. Pop ul a tion 0.000 108 < I % A ll I nfa nt s( < I year old) 0.000206 < I % Ch il dren 1-2 years o ld 0.000277 < 1 % Chi ldr e n 3-5 years o ld N / A N / A 0.000236 < I % N / A N / A Chil dr e n 6 -1 2yea r s o ld 0.000 157 < I % Yo uth 13- 19 yea rs o ld 0
. 0 00090 < I % Adult s 20-49 yea r s o ld 0.000088 < I % 0.000009 8.4x I 0 · 7 Adult s 5 0 + years o ld 0.000088 < I % N / A N / A Fe m a l

es 13

-49 yea r s o ld 0
.001538 < I % 0
.00 008 6 < I % 0.000009 8.4x 10 · 7 1 Mos t h1 g hl y ex pose d p o pul a ti o n s ubg roup 1 s d1 s playe d m b o ld
. 2 HED r epo rt s th e mos t hi g hl y ex pose d adult po pul a ti o n s u bg ro up fo r ca nce r assess me nt s. 

### V III. C h aracte riz ati o n of Inputs/Output s

T h e acu te a nd n o n- can ce r c hro nic di e tary (foo d and wa te r) ri s k assess m e nt s c onducte d for e th a lfl u ra lin a r e unr e fin e d and u sed to leran c e-l eve l res idu es a nd I 00% C T. A dditi o nal re fi ne m e nt s arc n o t re quire d at thi s tim es; h oweve r , th ese assess m e nt s co uld b e re fined if th e furu re , i f n eeded, u s in g fi e ld tri a l , PCT , o r PDP d a t a. T h e ca n ce r d ie t ary (foo d a nd wa ter) a ssess m e nt was re fin ed a nd u se d th e 

### Y2 LLMV value f o r a ll po t a to co mm o diti es (0. 0 25 ppm ), PCT a nd PDP d a ta f o r vari o u s co mm o ditie s, and toleranceleve l res id u es f o r a ll r e m a inin g c o mmoditi es. Th e can ce r d ie ta ry assess ment could b e furth e r re fin e d w ith a dditi o n a l PC T data , b y tran s latin g th e ava il a b le PDP d a t a to s imilar commoditie s, a n d/o r with fi e ld trial dat a for the commod it ie s th a t u se d to le r a n ce - le v e l res idues. Addition a l

Pa ge 7 o f 25Ethal flural in Dietary Exposure and Risk Assessment DP Number: 432016


### refinements were not incorporated into the assessment because they were not needed at this time. Water is the main driver in the cancer assessment (app rox imately 76% of the total exposure). IX . C onclu s ion s



### The acute and chronic dietary exposure and risk assessments demonstrate that estimated food and drinking water exposu res are not of concern. Chron ic cancer dietary (food and drinking wate r) exposures to ethaltlura l in yield a cancer risk es tim ate of 8.4x 

### l 

# o- 7 

### fo r adu lt s 20 -49 years o ld and females 13-49 years old, the most highly exposed adult population subgroups. HED is confident that the assessment does not underestimate risk to the general U.S. population or any population subg roup. X. List of A ttachm e nts 

### A ttachm ent I. Residues Used in Acute, Non-Cancer C hronic , and Cancer Assessments Attachmen t 2. Acute Dietary (Food Plus Water) Residue Input File Attachment 3. Acute Dietary (Food Plu s Water) Risk Assessme nt Results Attachment 4. Chronic Non-Cancer Dietary (Food Plus Water) Input File Attachment 5. Chronic Non-Cancer Dietary (Food Plus Water) Risk Assessment Results Attachment 6. Chronic Cance r Dietary (Food Plus Water) Input File Attachment 7
. Chronic Cancer Dietary (Food Plu s Water) Risk Assessment Results Attachment 8. Chron ic Ca nc e r D ietary Assessmen t Dr ive rs Attachment 9. C hroni c Ca nc er D ietary (Water Only) Ri sk Assessment Results Attachment I 0. Etha l tluralin SLUA

cc: J. Van Alstine (RAB6) RDI: DESAC Reviewers (01-04-2016); D. Davis (02-22-2016) J. Van Alstine:S I 0217:PY -S:(703)603-8866:7509P:RAB6

Page 8 of25Ethalnuralin Dietary E xpo s ure and Risk Asse ss men t DP Number: 4320 16



### Attachment 1. 

### Residues Use d in Ac ut e, Non-Ca nc e r C hr o n ic , a nd Ca nc e r Assessments

Tab le A. I. Res idu es Used in Acute , No n-Ca ncer C h r o ni c, a nd Ca n ce r Asse s s me nts. Ac ut e/ Non- Cancer Ac ut e , Non-Ca n cer C hr o ni c , and Ca n ce r Ca n ce r C hr o ni c A ss ess ment s • Co mm odity B S 2 Residue No. D etect s 

### I Residue Avg. Va lue PCT Data Sou r ce No
. Yl LO D 

### I Value PF C o mm e nt s (ppm) No. Zeroes (ppm) PCT3 Po tato , chips B 1 00 < I I P

o t

ato , dry B 1 0 0 < I 6.5 (g ranul es/ fl ak es) The c a nce r assess ment use d the half Pot a to , nour B 0.05 100 Y 2 LL MV 0.025 < I 6.5 LLMV va lu e si nce a ll fi eld tri a l r es idu es in



### -- p o ta t o we r e less t han t he LL MV of0.05 ppm . Po tato , tuber. N B / 1 00 < I I w

/ peel PB P

o t

a t

o, t uber, w / o N B / 1 00 < I I pee l PB Soy b ea n, see d B 10 0 S o ybea n 100 I The c ance r assess m e nt used th e ave rage S oyb ea n, o il B 100 100 I Soy b ea n , n o ur B 0
. 0 5 1 00 grain PDP 

# o 13 00 

### I 

# o 0.0005 100 I half LOD va lu e fr om the PDP data. data ; 2 011 Additi o na ll y, I00% CT was use d s in ce th e Soybean , soy milk B 1 00 1 00 I co mm o diti es are b lende d a nd m o nit orin g Soybean , soy Soy in fa nt d ata (that auto m a tica ll y acco unt fo r P CT) mil k-babyfood o r B 0.05 100 form ul a PDP 0 1 179 10 0.0025 100 I w ere used. infant dat a; 2013 Cann ed black C ann ed pin to bean P DP data w ere used in Bea n, b lack , seed B 0 .05 1 00 bean PDP 0 1367 10 0
.0 0 055 1 00 I da t a; 20 1 0 th e ca nce r assessmen t fo r a ll dry bea ns Canned e xce pt bl ack beans a nd kidn ey b ea ns s in ce kidne y b ea n pinto b ea ns had th e hi ghes t ave rage half Bea n , kidn ey, see d B 0
.0 5 100 0 13721 0 0.0014 100 I LOD valu e . Addition a ll y, 100 % CT wa s PDP dat a; use d s in ce th e co mm o diti es are bl end ed 2 008 ; 200 9

Pa ge 9 of25Ethalfluralin Dietary Expo s ure and Risk Asse ss ment DP Number: 432016

Table A.l. Residue s Use d in Acute , Non -C ancer C hro ni c, and Ca nc e r A ssess ments. Acute/Non- Cancer Ac ut e, No n- Ca n ce r C hro ni c, and Ca nc er Cancer Chronic Assess ments• Commo dit y BS 2 Re s idu e No. D etects 

### I Res idue Avg. Value PCT Data Sou r ce**No.~** LOD 

### I Value PF Comments (ppm) No. Zeroes (pn m) PCT 3 Bean , broad , seed B 10 0 100 I and monitoring data (that aut oma ticall y Bean , cowpea , B 100 100 I account for PCT) were used. seed Bean , great B 100 100 I nonh em, seed Canned pinto Bean , lima , seed B 0.05 100 bean POP 0 1 372 1 0 0.0015 100 I Bean , mung , seed B 1 00 data; 2009 100 I Bean , navy , seed B 100 100 I Bean , pink, seed B 100 100 I Bean. pinto , seed B 100 100 I Guar, seed B 100 100 I Chickpea , seed B 100 100 I The cancer assessment used the average Chickpea, flour B 100 Garbanzo 100 I half LOD value from the PDP data. Lentil , seed B 0.05 1 00 bean PDP 0 1 372 1 0 0.00 1 100 I Additionally , I00% CT was use d s inc e the Pea , dry B 1 00 data ; 2009; 100 I commoditi es ar e blended and monito rin g Pea , pigeon , seed B 100 2010 data (that automatically account for PCT) 100 I were used. Can taloupe NB / 100 Cantaloupe 5 I PB PDP data ; NB / 0.05 2003;2004; 0 1 1486 1 0 0.016 Hon ey dew melon PB 100 2005 100 I The cancer assessment used average half NB / Watem1elon LOD va lu es from the PDP data for Wat ermelon PB 0.05 100 PDP data; 

## o l 37t 

### I 

## o 0.003 20 I cantaloupe , watermelon , cucumber, 2010 summer squas h, and winter squash. The Bal sa m pear NB 0.05 100 Tolerance 

# -- 0.05 100 I cantaloupe PDP data were tran s lated to Chayote, fruit NB 0.05 100 Tolerance 

# -- 0.05 100 I honeyd ew. The remaining commodities Chinese waxgourd NB 0.05 100 Tolerance 

# -- 0.05 100 I used tolerance- level residues. NB / Cuc umb er Cucumber PB 0.05 1 00 PDP data ; 0 1 1474 1 0 0.0066 50 I 2009;20 1 0

Page 10of 25Ethal flur a lin Dietary Exposure and Ri sk As sess ment DP Number: 4320 16

T ab le A. I. Res i du es Used i n Ac ut e, No n-Ca nce r C hr o ni c , and C an cer A ssess me n ts. Ac ut e/No n- Ca n ce r Ac u te, No n -Ca ncer C hr o ni c , a nd C an ce r C an ce r C hr o ni c Assess me nt s 1 Co mm o dit y BS 2 Res idu e No . D et ec ts 

### I Res idu e Avg. V

a lu e PC T Da ta So ur ce No. 

### YI LO D 

### I Va lu e PC T 3 P F Co mm e nt s (p pm ) No. Ze r oes ( ppm ) Pumpkin NB / 0.05 100 Tolerance 0.05 30 I PB 

# -- Pumpkin, seed B 0.05 100 Tolerance 

# -- 0.05 30 I S umm e r Squash , s umm er NB / 0.05 100 Squas h PDP 0 1 895 10 0.0063 30 I PB data ; 20 1 2; 20 13 Winter Squas h, winter NB / 0.05 100 Squash PDP 0 1 1 1 15 1 0 0.003 30 I PB data ; 20 II ; 2012;20 13 Dill weed B 0.05 100 Tolerance


### -- 0.05 100 I Dill , seed B 0.05 100 Tolerance


### -- 0. 05 100 I Fl ax seed, oil B 0.05 1 00 Tolerance


### -- 0.05 1 00 I Rap eseed, oi l B 0.05 100 To lerance 0.05 < 2.5 I Use d tolerance-level va lu es for the acute , I



# -- Sesame , see d B 0.05 100 Tolerance


### -- 0.05 100 I chronic non-c a nce r a nd ca nce r Sesame , oi l B 0.05 100 Tolerance


# -- 0.05 100 I assessments. Safflower , oil B 0.05 100 Toleranc e 

# -- 0.05 100 I Sunflower , see d B 0
.05 100 To lerance 

### -- 0.05 10 I Sunflower , o il B 0.05 100 Tolerance 

# -- 0.05 10 I Water , direc t, a ll Acute: Used water numb ers provided by EFED in 

# - - 0.02612 Mode led sources 0.00036 Memo , M. B arre tt , 24 -F EB- 20 16 ; Water, indirect , a ll Chronic: 

### -- Value 

# -- -- --

-- 0.00057 D4 29863. sources Pea nut B 0.05 1 00 Tolerance 

# -- 0.05 25 I Th e acute and chro ni c assessments used Acute/ tolerance-leve l res idu es and I OO%CT. Th e Peanut Butter Chronic: cancer assessment used the average half Pea nu t, butter B 0.05 100 PDP da ta ; 0 1 719 1 0 0.00 1 1 00 1 .89x L OD va l ue f;om PDP for peanut butter 2006 Cance r : and to lerance-leve l residue s fo r the lx remaining commodities. The peanut butter

Page II of25E th alfl uralin Dietary Expo s ure and Risk As se s sment DP Number: 4320 16

Tab le A. I. Res idu es U s ed in Acute , No n-C anc e r C hroni c, a n d C anc e r As sess ment s. Ac u te/N onCa n cer C h ron i c Co mm o di ty B S 2 Resid u e Va lu e PCT D a ta So ur ce ( ppm)

Peanut , oi l B 0.05 100 Tolerance

----- ---·-·····- -- --- -- 1 PF = proce ss in g factor
. P CT = perc e nt crop treate d
. 2 B S = blending s tatus. 3 Average PCTdata from Memo , L. Yohannes , 17-JUN-2015. C ance r No. D etects 

### I Re s idu e No. 

### Yz LOD 

### I Value No. Zeroe s {ppm)



# -- 0.05

Pa ge 1 2 o f 25 Avg. PC T 3

?-

_ ) Ac ute , Non-Ca n ce r Chronic , a nd Ca n ce r Assess me nt s• PF Co mm e nt s proces s in g factor was se t to I x and I00% CT was used for the cancer asse s sme nt since th e PDP data are f or peanut butter I and already reflect th e effec t s of processing on residues and PCT. The ac ut e and non-cancer chronic assessments use th e DE E M default PF of 1 .89x.E th a 1flur a 1in Dietary Expo s ure and Ri sk A ssess ment DP Number: 4320 16


### Attac hm e nt 2. Ac ute Dietary (Food P lu s Water) R esi du e Input Fi l e Filename: C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated Assessment\Ethalfluralin_ACUTE
__ December 21 2015.R08 Chemical: Ethalfluralin, 113101 RfD{Chronic): .04 mg/kg bw/day NOEL{Chronic): 4 mg/kg bw/day RfD{Acute): .75 mg/kg bw/day NOEL{Acute): 75 mg/kg bw/day Q*= .089 Date created/last modified : 12-21

- 2015/13:22:37 Program ver. 3
. 16, 03-08

- d Comment: Standard UFs of lOOX apply
.**~--------------------- ----** **----- ------------** **----- ---------------------** **--------- ----**  Crop EPA Code Grp Commodity Name 0103296000 1C 0103297000 1C 0103297001 lC 0103298000 lC 0103298001 lC 0103299000 lC 0103299001 lC 0103300000 1C 0103300001 lC 0600347000 6 0600349000 6 0600349001 6 0600350000 6 0600350001 6 0603030000 6C 0603032000 6C 0603034000 6C 0603035000 6C 0603036000 6C 0603038000 6C 0603039000 6C 0603040000 6C 0603041000 6C 0603042000 6C 0603098000 6C 0603098001 6C 0603099000 6C 0603182000 6C 0603182001 6C 0603203000 6C 0603256000 6C 0603256001 6C 0603258000 6C 0603348000 6C 0603348001 6C 0901075000 9A 0901187000 9A 0901399000 9A 0901400000 9A 0902021000 9B 0902088000 98 0902102000 9B 0902135000 9B 0902308000 9B 0902309000 9B 0902356000 9B 0902356001 9B 0902357000 9B 0902357001 9B 1901144000 19A 1902143000 19B 2001163000 20A 2001319000 20A Potato, chips Potato, dry {granules/ flakes) Potato , dry (gra nu les/ flakes)

- b Potato , flour Potato , flour-babyfood Potato , t ub er , w/peel Potato , tuber, w/peel-babyfood Potato , tuber, w/o peel Potato, tuber, w/o pee l- babyfood Soybean, seed Soybean, soy milk Soybean, soy milk

- babyfood or in Soybean, oil Soybean, oil

- babyfood Bean, black, seed Bean, broad, seed Bean, cowpea, seed Bean, great northern, seed Bean, kidney, seed Bean, lima, seed Bean, mung, seed Bean, navy, seed Bean, pink, seed Bean, pinto, seed Chickpea, seed Chickpea , seed-babyfood Chickpea, flour Guar, seed Guar , seed-babyfood Lentil, seed Pea, dry Pea, dry

- babyfood Pea, pigeon, seed Soybean, flour Soybean, flour-babyfood Cantaloupe Honeydew melon \olatermelon Watermelon, juice Balsam pear Chayote, fruit Chinese waxgourd Cucumber Pumpkin Pumpkin, seed Squash, summer Squash, summer - babyfood Squash, winter Squash, winter-babyfood Dillweed Dill, seed Flax seed, oil Rapeseed , oil

Page 13 of 25 Def Res (ppm) 0.050000 0
. 050000 0.050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0
. 050000 0 .050000 0.050000 0
. 050000 0.050000 0.050000 0.050000 0
. 050000 0
. 050000 0.050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0.050000 0 .0 50000 0.050000 Adj.Factors Ill 112 1.000 6 .5 00 6
. 500 6 .5 00 6
. 500 1. 000 1. 000 1
. 000 1
. 000 1
. 000 1
. 000 1. 000 1. 000 1
. 000 1.000 1.000 1.000 1
. 000 1.000 1
. 000 1.000 1.000 1.000 1.000 1.000 1
. 000 1.000 1.000 1.000 1
. 000 1.000 1. 000 1
. 000 1.000 1. 000 1
. 000 1.000 1
. 000 1.000 1.000 1.000 1.000 1.000 1
. 000 1.000 1.000 1
. 000 1.000 1.000 1. 000 1
. 000 1. 000 1. 000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.0 00 1.000 1.000 1. 000 1
. 000 1
. 000 1.000 1. 000 1
. 000 1.000 1.000 1.000 1.000 1
. 000 1
. 000 1. 000 1.000 1
. 000 1
. 000 1. 000 1
. 000 1 .000 1
. 000 1
. 000 1.000 1. 000 1.000 1
. 000 1
. 000 1. 000 1
. 000 1.000 1
. 000 1
. 000 1
. 000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 CommentE thaltluralin Dietary Exposure a nd Ri sk Assessment DP Numbe r : 432016

2001319001 20A Rapeseed, oil-babyfood 0
. 050000 1
. 000 1.000 2001336000 20A Sesame, seed 0.0 5 0000 1.000 1.000 2001336001 20A Sesame, seed-babyfood 0.050000 1.000 1.000 2001337000 20A Sesame , oil 0.050000 1.000 1.000 2001337001 20A Sesame , oil-babyfood 0.050000 1.000 1
. 000 2002330000 20B Safflower, o i l 0
. 050000 1.0 00 1
. 000 2002330001 20B Safflower, oil -bab yfood 0.050000 1. 000 1
. 000 2002364000 20B Sunflower, seed 0
. 050000 1. 000 1
. 000 2002365000 20B Sunflower, oil 0
. 050000 1.000 1.000 2002365001 20B Sunflower , oil

- babyfood 0.0 5 0000 1. 000 1.000 8601000000 86A \•later, direct, all sources 0.026120 1
. 000 1.000 8602000000 86B vlater, indirect, all sources 0.026120 1.000 1.000 9500263000 0 Peanut 0.050000 1.000 1.000 9500264000 0 Peanut, butter 0.050000 1.890 1.000 950026 5 000 0 Peanut, oil 0
. 050000 1
. 000 1. 000 

### Attac hment 3 . Acute Di e tary (Food P l us Water) Ri s k Assess m e nt Results

US EPA DEEM- FCID ACUTE Analysis for ETHALFLURALIN, 113101 Residue file: Ethalfluralin_ACUTE
__ December 21 2015 .R 08 ver. 3
. 18, 03-08-d NHANES 2003-2008 2-Day Adjustment factor #2 used. Analysis Date: 12 -21-2015/ 13:25:37 Residue file dated: 12-21-2015 /13 :22:37 NOEL (Acute) = 75.000000 mg/kg body-wt /day RAC/FF intake summed over 24 hours Run comment: " Standard UPs of 100 X apply." Summary ca l culations--per capita: 95th Percentile---- 99th Percentile---

- ---99.9th Percent ile

- - -- Exposure % aRfD MOE Exposure % aRfD MOE Exposu re % aRfD MOE Female 13-49: 0
. 001538 0.21 48753 0
. 002208 0.29 33960 0
. 003034 0.40 24716

Page 14 of25E th a lnura l in Di etary Expo s ur e a nd Ri sk Assess me nt DP Numb er : 4 32 016


### A tt ac hm e nt 4. C hr o ni c N on- Ca ncer Di e tar y ( F oo d P lu s Wat e r) Input File Filename: C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated Assessment\Ethalfluralin CHRONIC December 21 2015.R08 Chemical: Ethalfluralin,-113101

-- RfD(Chronicl: .04 mg/kg bw/day NOEL(Chronicl: 4 mg/kg bw/day RfO(Acutel: .75 mg/kg bw/day NOEL(Acute): 75 mg/kg bw/day 0 * = . 089 Date created/last modified : 12-21-2015/13:23:19 Program ver. 3
. 16, 03-08

- d Comment: Standard UFs of 100X app l y .**~---------------------- ------------------** **----------------------- --** **---------** Crop EPA Code Grp Commodity Name 0103296000 1C 0103297000 1C 0103297001 1C 0103298000 1C 0103298001 1C 0103299000 1C 0103299001 1C 0103300000 1C 0103300001 1C 0600347000 6 0600349000 6 0600349001 6 0600350000 6 0600350001 6 0603030000 6C 0603032000 6C 0603034000 6C 0603035000 6C 0603036000 6C 0603038000 6C 0603039000 6C 0603040000 6C 0603041000 6C 0603042000 6C 0603098000 6C 0603098001 6C 0603099000 6C 0603182000 6C 0603182001 6C 0603203000 6C 0603256000 6C 0603256001 6C 0603258000 6C 0603348000 6C 0603348001 6C 0901075000 9A 0901187000 9A 0901399000 9A 0901400000 9A 0902021000 9B 0902088000 9B 0902102000 9B 0902135000 9B 0902308000 98 0902309000 9B 0902356000 9B 0902356001 98 0902357000 9B 0902357001 9B 1901144000 19A 1902143000 19B 2001163000 20A 2001319000 20A Potato, chips Potato, dry (gra n ules/ flakes) Potato, d r y (granules/ flakes)-b Potato , flour Potato, flour-ba b yfood Potato , t u ber , w /peel Potato, tuber, w/peel-babyfood Potato, tuber, w/o peel Potato, tuber, w/o peel-babyfood Soybean, seed Soybean, soy milk Soybean, soy milk-babyfood or in Soybean, oil Soybean, oil

- babyfood Bean, black, s e e d Bean, broad, seed Bean, cowpea, seed Bean, great northern, seed Bean, kidney, seed Bean, lima
. seed Bean, mung , seed Bean, navy, seed Bean, pink, seed Bean, pinto, seed Chickpea , seed Chickpea, seed-babyfood Chickpea, flour Guar , see d Guar, seed

- bab yfood Lenti l , see d Pea , dry Pea, dry-babyfood Pea, pigeon, seed Soybean , flour Soybean, flo u r - babyfood Cantaloupe Honeydew melon Watermelon Watermelon, juice Balsam pear Chayote, fruit Chinese waxgourd Cucumber Pumpkin Pumpkin, seed Squash, summer Squash, summer-babyfood Squash, winter Squash, winter-babyfood Dill weed Dill, seed Flax seed, o i l Rapeseed, oil

Page 15 o f 2 5 Def Res (ppm) 0.050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0
. 050000 0.050000 0.050000 Adj
. Factors #1 112 1. 000 1. 000 6
. 500 1.000 6
. 500 1.000 6
. 500 1.000 6
. 500 1. 000 1. 000 1
. 000 1
. 000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1
. 000 1. 000 1. 000 1. 000 1
. 000 1. 000 1
. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1. 000 1.000 1.000 1.000 1
. 000 1. 000 1. 000 1. 000 1. 000 1.000 1
. 000 1
. 000 1.000 1. 000 1. 000 1.000 1
. 000 1.000 1
. 000 1.000 1
. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1
. 000 1. 000 1. 000 1.000 1
. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1
. 000 1
. 000 1. 000 1. 000 1
. 000 1.000 1. 000 1. 000 1.000 1.000 1.000 1.000 1. 000 1. 000 1. 000 1. 000 Comm en t

### E th alflural in Di eta ry Ex p os ure a nd Ri sk Ass ess ment DP N um be r : 4320 1 6

2001319001 20A Rapeseed, oil

- babyfood 0
. 050000 1.000 1.000 2001336000 20A Sesame, seed 0
. 050000 1. 000 1.000 2001336001 20A Sesame, seed- babyfood 0
. 0 5 0000 1.000 1.000 2001337000 20A Sesame, oil 0
. 050000 1.000 l. 000 20013 3 7001 20A Sesame, oil-babyf ood 0
. 0 5 0000 1. 000 1.000 20023 3 0000 20B Safflo w er , oil 0
. 0 5 0000 1. 000 1.000 2002330001 20B Safflower, oil-babyfood 0
. 050000 1. 000 1
. 000 2002364000 208 Sunflower, see d 0
. 0 5 0000 1. 000 1. 000 2002365000 208 Sunflower, oil 0
. 050000 1. 000 l. 000 2002365001 20B Sunflower, oil-babyfood 0
. 050000 1. 000 1.000 8601000000 86A Water, direct, all sources 0
. 000570 1.00 0 1.000 8602000000 86B l'iater, indirect, all sources 0
. 000570 1
. 000 1. 000 9500263000 0 Peanut 0.050000 1.000 1.000 9500264000 0 Peanut, butter 0
. 050000 1.890 1. 000 9500265000 0 Peanut, oil 0
. 050000 l. 000 1.000 

### A ttachm e nt 5
. C hr o ni c Non- Ca nc er Di et a ry (Foo d Plu s W a t e r ) R is k Assess m e nt R es ult s

US EPA DEEM-FCID Chronic analysis for ETHALFLURALIN, 113101 Residue file name: Ver. 3.16, 03

- 08

- d NHANES 2003-2008 2-day C:\Users\j1angsda\Documents\Chemica1s\Ethalfluralin\Dietary\Updated Assessment \ Ethalfluralin_CHRONIC
__ December 21 2015.R08 Adj ustment factor U2 used
. Analysis Date 12-21-2015/13 : 26 : 55 Residue file date d : 12-21-2015/13 : 23:19 Reference dose (RfD , Ch ronic) = . 04 mg/kg bw/day COM MENT 1: Standard U F s of 1 0 0X apply
. Total e xp os u re by population subgrou p
Total Exposure Population

Subgroup To tal OS Population Hispan i c No n -H is p- Wh ite No n -Hisp-B l ack Non- H is p - Other Nursing Infants Non-Nu r sing Infants Female 13+ PREG Children 1-6 Children 7-12 Male 13-19 Female 13-19/NP Male 20+ Fema l e 20+/NP Senio r s 55+ All Infants F emale 13-50 Children 1- 2 Children 3- 5 Chil dren 6-12 Yout h 13

- 19 Adults 20-49 Adults 50-99 Pemale 13-49 mg/kg body wt /d ay 0.000108 0
. 000107 0
. 000 1 09 0.000095 0
. 000128 0.000096 0.000256 0.000108 0.0002 46 0
. 000147 0
. 000094 0.000086 0.000089 0.000087 0.000087 0.000206 0
. 000086 0.000277 0.000236 0.000157 0.000090 0.000088 0.000088 0.000086



### Pa ge 1 6of 2 5 Percent of Rfd 0.3 \ 0
. 3\ 0
. 3% 0
. 2% 0
. 3% 0.2% 0.6% 0.3% 0.6\ 0 .4 \ 0 .2\ 0 .2 % 0 .2 % 0
. 2% 0
. 2\ 0.5\ 0.2% 0
. 7 \ 0.6 \ 0.4\ 0.2 \ 0.2 \ 0.2 \ 0.2 \E th a\flur a lin Dietary Exposure and Risk Assessment DP Numbe r : 432016


### A tt achment 6. C hronic Cancer Di e tary (Food Plu s Water) Input F ile Filename: C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated Assessment\Ethalfluralin_CANCER_January 4 2016.R08 Chemical: Ethalfluralin, 113101 RfD(Chronic): .04 mg/kg bw/day NOEL(Chronic): 4 mg/kg bw/day RfD(Acute): .75 mg/kg bw/day NOEL(Acute): 75 mg/kg bw/day**~** .089 Date created/last modified: 01-04-2016/13:48:40 Program ver. 3.16, 03-08-d



## ------------------------------------- ----- -------------------------- - ----------- --- Crop EPA Code Grp Commodity Name 0103296000 1C 0103297000 1C 0103297001 1C 0103298000 1C 0103298001 1C 0103299000 1C 0103299001 1C 0103300000 1C 0103300001 1C 0600347000 6 0600349000 6 0600349001 6 0600350000 6 0600350001 6 0603030000 6C 0603032000 6C 0603034000 6C 0603035000 6C 0603036000 6C 0603038000 6C 0603039000 6C 0603040000 6C 0603041000 6C 0603042000 6C 0603098000 6C 0603098001 6C 0603099000 6C 0603182000 6C 0603182001 6C 0603203000 6C 0603256000 6C 0603256001 6C 0603258000 6C 0603348000 6C 0603348001 6C 0901075000 9A 0901187000 9A 0901399000 9A 0901400000 9A 0902021000 9B 0902088000 9B 0902102000 9B 0902135000 9B 0902308000 9B 0902309000 9B 0902356000 9B 0902356001 9B 0902357000 9B 0902357001 9B 1901144000 19A 1902143000 19B 2001163000 20A 2001319000 20A 2001319001 20A Potato, chips Potato, dry (granules/ flakes) Potato, dry (granules/ flakes) -b Potato, flour Potato, flour

- babyfood Potato, tuber, w/peel Potato, tuber, w/peel

- babyfood Potato, tuber, w/o peel Potato, tuber, w/o peel-babyfood Soybean, seed Soybean, soy mi lk Soybean, soy milk-babyfood or in Soybean, oil Soybean, oil

- babyfood Bean, black, seed Bean, broad, seed Bean, cowpea, seed Bean, great northern, seed Bean, kidney, seed Bean, lima, seed Bean, mung, seed Bean, navy, seed Bean, pink, seed Bean, pinto, seed Chickpea, seed Chickpea, seed

- babyfood Chickpea, flour Guar, seed Guar, seed

- babyfood Lentil, seed Pea , dry Pea, dry-babyfood Pea, pigeon , seed Soybean, flour Soybean , flour-babyfood Cantaloupe Honeydew melon Watermelon Watermelon, juice Balsam pear Chayote, fruit Chinese waxgourd Cucumber Pumpki n Pumpkin, seed Squash, summer Squash, summer-babyfood Squash, winter Squash, winter-babyfood Dill weed Dill, seed Flax seed, oil Rapeseed , oil Rapeseed, oil-babyfood

Pa ge 1 7of25 Def Res (ppm) 0.025000 0
. 025000 0.025000 0.025000 0.025000 0.025000 0.025000 0.025000 0.025000 0.000500 0.000500 0.002500 0.000500 0.000500 0.000550 0.001500 0.001500 0.001500 0.001400 0.001500 0.001500 0.001500 0
. 001500 0.001500 0.001000 0.001000 0.001000 0.001500 0.001500 0.001000 0.001000 0.001000 0.001000 0.000500 0.000500 0.016000 0.016000 0.003000 0.003000 0.050000 0.050000 0.050000 0.006600 0.050000 0.050000 0
. 006300 0.006300 0.003000 0
. 003000 0.050000 0.050000 0.050000 0.050000 0.050000 Adj
. Factors Ill 112 1.000 0
. 010 6.500 0
. 010 6.500 0
. 010 6.500 0
. 010 6.500 0
. 0 10 1.000 0.0 1 0 1.000 0.0 1 0 1.000 0.0 1 0 1.000 0
. 010 1.000 1
. 000 1.000 1
. 000 1.000 1
. 000 l. 000 1. 000 l. 000 l. 000 l. 000 l. 000 l. 000 1. 000 1. 000 l. 000 1. 000 l. 000 l. 000 l. 000 1
. 000 1.000 1. 000 l. 000 1.000 1.000 1.000 1.000 1.000 1.000 l. 000 l. 000 l. 000 1. 000 l. 000 l. 000 1.000 1.000 1.000 1.000 1.000 1.000 1
. 000 1.000 1.000 1.000 l. 000 l. 000 l. 000 l. 000 1.000 1.000 1.000 0
. 050 l. 000 1. 000 1.000 0
. 200 1. 000 0
. 200 1. 000 l. 000 1.000 1.000 1. 000 1. 000 l. 000 0
. 500 1.000 0 .300 1. 000 0
. 300 1.000 0 .300 1. 000 0
. 300 1.000 0.300 1.000 0.300 1.000 1.000 1.000 1.000 1.000 1.000 l. 000 0
. 025 1.000 0
. 025 CommentE tha lflur a l in Di e t ary E xp os ur e and Ri sk Assess ment DP Num be r : 43 20 16

2001336000 20A Sesame, seed 0
. 050000 1.000 1.000 2001336001 20A Sesame, seed-babyfood 0
. 050000 1.000 1.000 2001337000 20A sesame, oil 0
. 050000 1.000 1.000 2001337001 20A Sesame, oil-bab yfood 0
. 050000 1. 000 1. 000 2002330000 20B Safflower, oil 0
. 0 5 0000 1. 000 1. 000 20023 3 0001 20B Safflo w er, oil-bab yfood 0
. 0 5 0000 1. 000 1. 000 200236 4 000 20B Sunflower, see d 0
. 050000 1. 000 0
. 100 2002365000 20B Sunflower, oil 0
. 050000 1. 000 0.100 2002365001 20B Sunflower, oil-babyfood 0
. 050000 1. 000 0.100 8601000000 86A Water, direct, all sources 0
. 000360 1. 000 1.000 8602000000 86B Water, indirect, all sources 0.000360 1.000 1.000 9500263000 0 Peanut 0 .05000 0 1.000 0 .25 0 9500264000 0 Peanut, butter 0 .0010 00 1.000 1.000 9500265000 0 Peanut, oil 0.050000 1.000 0 .250 

### A ttachment 7 . C hr o ni c Ca nc e r Di e tary (Foo d Plu s Wat e r) Ri s k Ass e ss m e nt R es ults US EPA DEEM-FCID Chronic analysis fo r ETHALFLURALIN , 113101 Residue file name: Ver. 3.16 , 03

- 08-d NHANES 2003-2008 2-day C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated Assessment \Ethalfluralin_CANC ER

_ January 4 2016.R08 Analysis Date 01-04-2016/13 :49:35 0* = 0
. 089 Adjustment factor U2 used. Residue file dated: 01-04-2016/13:48:40
Total exposure by population subgroup

Population

Subgroup Total us Population Hispanic Non-Hisp-White Non-Hisp-Black Non-Hisp-Other Nursing Infants Non-Nursing Infants Female 1 3+ PREG Child r e n 1-6 Childre n 7-12 Male 13-19 Female 13-19/NP Male 20+ Female 20+ / NP Seniors 55+ All Infants Female 13-50 Children 1-2 Children 3 -5 Children 6-12 Youth 1 3-19 Adults 20

- 49 Adults 50-99 Pema1e 13

- 49 To t al Exposure mg/kg body wt/day 0.000010 0
. 000010 0
. 000010 0.000008 0. 0000 11 0.000018 0.000051 0.000010 0.000014 0.000009 0.000007 0.000007 0.000009 0.000010 0
. 000009 0
. 000041 0
. 000009 0
. 00001 6 0.000013 0.000009 0.000007 0.000009 0
. 000009 0.000009

P

a ge 18 o f 25 Lifetime risk (Q * = . 089) 8.83E-07 9.06E-07 8.98E-07 7.20E-07 1.02E -06 1.57E -06 4.55E-06 8.46E -07 1.24E -06 7.77E -07 6.20E-07 6.51E-07 7.86E-07 8.77E-07 8.09E-07 3.63E-06 8.39E-07 1.41E-06 1.17E-06 8.15E-07 6.35E-07 8.40B

- 07 8.26E-07 8.40B

- 07E th a 1flura1in Dietary E xpo s ure and Ri s k A ss e ss ment DP Number: 4320 16


### Atta c hment 8. C hronic Cancer Di etary A ss e ss m e nt Drivers US EPA DEEM -F CID Chronic analysis for ETHALFLURALIN, 113101 Resi du e f i le n ame : ver. 3.16 , 0 3

- 0 8-d NHAN ES 2003-2008 2- day C:\Users\jlangsda\Docume n ts\C h e mi cals\Ethalflural in \D iet ary\Updated Assessment\Ethalfluralin_CANCER_J a n uary 4 2016.R08 Adj u stme n t factor H2 u sed
. Analysis Date 01-04-2016/13 : 50 : 09 Q* = 0
. 089 Residue file dated : 01

- 04-2016/13 : 48 : 40



### ====== ======== ============== ======================= === = =

=

=

===================== Critical Commodity Contribution Analysis for Total US Population Total Exposure = . 0000099 mg/kg bw/day Crop groups wi t h tot a l exposure contri b ution > 1\ Foods/Foodforms w ith exposure co n t r i b u ti o n > 1% Crop group Food Food form Crop Group = (0) Other Pea n u t (9500263000): FoodForm N/S T o t a l f or crop group ----------- E x posure analysis-------

--- mg/kg 

### I %of Totall Lifetime Risk body wt/dayj E x posure 

### I (Q*=
. 089) -----------1-- - - --- - -- -1-------- -- - - --

0
. 0000004 4
. 22% 3
. 73E-08 -----------l-

-- - --- ---- l

--------------

0
. 0000005 5
. 1 5% 4. 55 E -0 8 Crop Group = ( 1 ) Root and T u ber Vegetables Potato, tuber , w/o peel (0103300000): FoodForm N/S 0
. 0000001 1.18% 1
. 04 E- 08 -----------l-----------l-------------- Total for crop group 0.0000002 1
. 89% 1.67E-08 Crop Group = (1C) Tuberous and Corm Vegetables Potato, tuber, w/o peel (0103300000): FoodForm N/S 0
. 0000001 1
. 18% 1
. 04 E -08 

## -----------l----------- 1

-------------- Total for crop group 0
. 0000002 1
. 89% 1.67E-08 Crop Group = (6) Legume Ve g et a bles (S u cculent or Drie d ) Total for crop group 0
. 0000002 1
. 56% 1
. 38E-08 Crop Group = (6C) Dried Shelled Pea/Bean (exc Soybean)

Total for crop group 0.0000002 1. 56% 1.38E-08 Crop Group = (9) CUrcurbit Vegetables Cucumber (0902135000): FoodForm N /S Honeydew melon (0901187000) : FoodForm N/S Total for crop group Crop Group = (9A) Melons Honeydew melon (0901187000) : FoodForm N/S Total for crop group Crop Group = (9B) Squash/Cucumbers Cucumber (0902135000): FoodForm N/S 0.0000003 2.75% 2.43E

- 08 0.0000001 1. 48% 1
. 30E-08 -----------l----------- l

--------------

0.0000007 7
. 39% 6
. 5 3E

- 08

0.0000001 1.48 % 1
. 30E

- 08 -----------l-----------l--------------

0.0000003 2
. 77% 2
. 44E-08

0.0000003 2
. 75% 2
. 43E-08

Pa g e 19 of25Ethal flura l in Diet ary Exposure and Ri sk Assess me nt DP Number: 4320 16

Total f or crop group Crop Group = (20) Oilseeds Safflowe r, o il

- babyfood (2002330001) : F ood F orm N /S T otal for crop g r oup Crop group Food Food form Crop Group 

### = (20A) Rapeseed Total for crop g r oup Crop Group = (20B) Sunflower Saffl o wer, oil-babyfood (2002330001) : FoodForm N/S Total for crop gr oup Crop Group = (86) Water ------- --- - l-- ---------l-------------- 0
. 0000005 4.63% 4. 08 E

- 08

0.0000003 2
. 7 6% 2
. 44E-08



## ------ --- --1

-- ---------1--------

------

0
. 000000 5 4
. 74% 4
. 19E-08

----------- Exposure analysis--

------ -- rng/kg 

### I %of Totall Lifetime R isk body wt /d ayl Exposure 

### I (Q*=
. 089)



## ----- ------1- ----------1-----

------ ---

0
. 0000001 1. 05% 9
. 23E

- 09

0
. 0000003 2
. 76% 2 .44 E

- 08



## --- --------1--

--- ----- -1-

---------- ---

0
. 0000004 3.6 9% 3
. 26E-08
Water, d irec t, al l sources (8601000000): FoodForrn N /S 0
. 00000 48 48
. 36% 4
. 27 E -07 Water , i nd irect , a ll sources (8602000000) : FoodForm N/S 0
. 0000027 27
. 61% 2
. 44E-07



## ----------------------- -------------- - ---------- - 1

-- - ---- -- --1---------

-- --- Total for crop gr oup 0
. 000007 5 75
. 97% 6
. 71E-07 Crop Group 

### = (86A) Direct W a t er Water, direct, all sources (8601000000) : FoodForm N/S 0
. 00000 4 8 48
. 36% 4
. 27E-07



## ------- --- ------- ------------------- -- ------- - -- - 1

---------- -1-----

-- -- ----- Total for crop g roup 0
. 0000048 48.36% 4
. 27E-07 Crop Group = ( 86 B ) In direct \<later Water, i nd irec t, all sources (8602000000) : F oodForm N/S 0
. 0000027 27
. 61% 2.44E-07



## ---------------------------- --- - ------ --------- - -1-------

---- 1-

--- ----------

Total for crop group 0
. 0000027 27
. 6 1 % 2 .44 E-07 Total for crop groups l isted above : 0
. 0000096 96
. 71% 8
. 54E-07

Pa ge 20 of25Etha lfluralin Dietary Expo s ure and Ri sk Assessment DP Number: 432016


### Attac hm e nt 9 . C hr o ni c Ca ncer Dietary (Water Only) Input F ile and Ri s k Assess m e nt Re s ults File name: C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated Assessment\Ethalfluralin_CANC E R WATE R O NLY _Nov 30 20 15
. R08 Chemical : Ethalfluralin, 113101 RfD(Chronic):
. 04 mg/kg bw/day NOEL(Chronic): 4 mg/kg bw/day RfD(Acute): .75 mg/kg bw/day NOEL(Acute) : 75 mg/kg bw/day Q * = . 089 Date created/last modified: 11-30-2015/11 : 53:03 Pr ogram ve r. 3.16, 03

- 08-d Commen t: Standard UFs of lOO X app ly
. EPA Crop Def Res Adj .F actors Comm ent Code Grp Commodity Name (ppm ) Ill 112



## ---------- --- --------- --- --------- -- ----- ---------- ------- 8601000000 86A Water, direct, all sources 0
. 000360 1
. 000 1
. 000 8602000000 868 Water, indirect, all sources 0
. 000360 1 .000 1. 000

US EPA DEEM -FCID Chronic analysis for ETHALFLURALIN, 113101 Residue file name : Ver. 3.16, 03-08-d NHANES 2003-2008 2-day C:\Use rs \jlangsda\ Documents\C hemi cals\E thalflurali n \Dietary\Upda ted Assessment\Etha lflu ralin_CANC ER**I~AT ER**  ONLY_Nov 30 2015 .R08 Analysis Date 11-30-2015/11 :53:4 6 Q • 

### = 0
. 089 COMMENT 1: Standard UFs of 100 X apply. Adjustment factor 112 used. Residue file dated : 11-30-2015/11:53 : 03

===== ==== ===•============================ == ====a==== ==== ===a • c== ====== =•===== == Total exposure by popu l at i on su bgroup

Population

Subgro up Total US Population Hispanic Non-Hisp-White Non-H isp-Bl ack Non-Hisp-Other Nursing In fa nt s Non -N ursing Infants Female 13+ PREG Children 1-6 Children 7-12 Male 13-19 Female 13-19/N P Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13 -50 Chi ldren 1-2 Childre n 3-5 Child ren 6-12 Youth 13-19 Adults 20 -49 Adults 50-99 Female 13 -4 9 Total Exposure mg/kg b ody wt /da y 0
. 000008 0.000007 0
. 000008 0
. 000006 0.000009 0.000007 0
. 000025 0.000007 0.000010 0
. 000006 0
. 000005 0.000006 0
. 000007 0
. 000008 0
. 000007 0.000019 0.000008 0
. 000011 0
. 000009 0
. 000007 0
. 000005 0.000008 0
. 000007 0.000007

Page 2 1 of25 Lifetime risk (Q • = . 089) 6
. 71 E- 07 6 .41E- 07 6.90E-07 5
. 54E-07 7
. 73E-07 6 .07E-07 2 .23E -06 6
. 32 E- 07 8.59E

- 07 5.59 E- 07 4.61E-07 5
. 17E-0 7 6 .25E-07 7
. 05 E-07 6 .49E- 07 1
. 73E-06 6 .68E-07 9 .6 8E-07 8 .15E- 07 5.88E

- 07 4.89E-07 6.69E-07 6 .62E-07 6.67E-07

### Ethalflura lin Dietary Exposu re and Risk Asses s ment DP Number: 4320 16


### A ttachment 10 . E thalfluralin S L UA

UNITED STATES E NV IRO NM ENTAL PROTECTION AGENCY WASH I NGTON DC 2 0460 

### JUN I 7 2015

:><r :;cor C"( l.' lCAl SM LIY I,**~D** f'Oll UTIO r ;**PREVEH~** IC II ;\ 1 E.\ 1 0RAN D Ui\1 SCH. I ECT : Screening Level Usag e 1 \n ulysis (SLLA) Re po rt f o r Etha lll u r ali n ( PC Co de fl I 131 0 I). in S u pp o rt of Dru ft Risk Assess ment for Rc gis l r..tli o n R c , · i cw F R OM :

T HR U: 

### I....P , \.,f,;._f!A AA/IIVI ' l.i abc th Yohannc s. Biologist 

## r!V ·**~v** ·**~** S c ienc e and lnfom1a t ion Ana l ysis Brandt Bio logicu l a nti Ecunomil: Analysis Di, · isjo n (7503 1') 

## /I_ ,l ) D iann Sims. Chief

## }JJ..tl-ll-i**t.J )~U\""'**  Science l n t or mnti o n nn d /\nn l y s i s Urnn c h Biolo gica l a n d Ec on omic Annlys i s D i\'i sio n (75031') T O: Kell y B ullun.l. C hemical Review Mana g er Ri sk Man ageme nt and lm p h :me nt a ti on B rn ncl t I Pes ti c i de R ee v a lua t io n Di\'i s io n (750 SP) T h i s mcm o rwt d um transm it s an u pda t e o f th e Ethaltl u rnlin Screening Level L:s a ge Ana ly sis (SLU1 \) report com p le ted i n 20 I 0 (usage d a ta fro m 200 I to 2007) w i th the must rece nt Ethal llu rali n SJ.l j A c o mpleted i n2 0 1 5 (us ug c tlutu from :! 00 4 tu 2013). Etha lllurali n i s a se l ective he rb i c i d e used fo r the p re cmerge n ec con trol o f nnnual**as~cs** anti broa tlkaf weed s in foo d and feed cro ps . It was ti rs t n : g i st l"J e J i n I 980. UascJ o n ;wailn b lc da ta from 200 4 to 20 1 3, the h ig he s t reported**us<:~gc** of c thnl ll u rali n was o n c ucumbers . s q uash
. pumpkins. dry beans/peas. pe a n u ts. an d w nte m1 clons
. as meas u re d by a \'cra ge an n uu l percent crop treate d
. In te rm s 

## or ave ra ge u nnuu l lhs a.i. ap p lie d. the h ighest usa g e was on d ry beans/ peas . pean u ts , s unflowers .**so~** bean s . untl pu m pkin s . a nd \\ ' ut

enndons. S ince the last SLUA in 20 1 0. there ha\'c been**~:hangcs** i n e tha l lluralin u sug e**~·n** scve r..tl**~:rops.** 1 \ s rncu surcd b y overage annual percent c ro p trc utc tl ( PCT ) , t he re was an i n crcaso.: in e thal ll w ·a li n u sag o.: on lour cro ps and a de c rease i n u s age on four cro p s. T h e g re a t est i nc reases i n u sage w ere on pumpkin s ( from 25 to 3 0 PCT) and sq uas h (from 25 tu 30 P C T )
. whi l e th e greatest decrease wa s u n su nn o wcrs ( from 20 to 10 PCT). nu.:rc wa s a five pcrcc n t d ecline in :l\'cmge annual PCT un peanuts t3 0 to 25 PCT). d r y be a n sl p e a s (from 30to 25 I' C T ). and canta lo upes (from 1 0 to 5 I'CT). As mea s ured by average annu nllb s a . i applied. th e r e was an inc reas e in cthulllura li n u sngc on o nl y two cr o p s : green bcuns ( fro m 1. 00 0 to 6
. 000 lb s . u.i .) a n d potatoes ( from 1. 000 tu 2
.000 lb s. u.i. ). Usu ge tlec reusctl o n ei g h t ot h er cro p s . w i th th e greates t ann ual decreases occ urrin g on

Page 22 of25Ethal flu rat in Dietary Expo s ure and Ri s k A ssess ment DP Number: 432016

:.un lhmc 1:- t I"IPIII -1 00.000 ,,, 20 11 .000 l h:-. :r.i.). pea nu t:. (!rum 300.000 t o**~00.000 b~.**  a. i. ). a n J Stlyhca n s ( l'ro 111 70.000 h 1-I IJ. 00 t ) l h !>. a . i .). I n the 1110"1 r..·ccnt**I** l**\(.~Ill:').** u.;;t :,: .. · "a' nnltmgcr r.:pon.: d on tmr.ms. pca.:hc-; :md cln:r ric-;**\.~:"** u:.a)!t: \\a.., n.:pon.:d 1111**.:ab a~-:.**  :1 <:top'' i t h n o uc ti \ c cmJ UM.' prudut:t re gis tra tion o r Scl.'tion I X**t:nK-rgciK~** e\l.' lll p ti tms at tht: tnlW ot'**thi~** report. ;o-;otc th:tt u :.agc con ti nues to be rcp o rh.:d o n**!:!rc~.· n** **h~.·an~.** J!rccn pc:t s. : lll d pe p per-: . :t lt hnugh t hese crops arc al so n ot I.: no\ \ n to he l i sk'J o n**~.·ti\** c**mlu~c** p roduct**rq..ti-;trat on~**  o r a:- Sl.'l' t ion IS**cm cq!** **t:IH .:~**  c.xt.:lllp ti u n s at th i s ti me. Fo r quc, t itlll-:. co !llllh 'llh
. t nt! oth.:r th.t gt: rn tilrtll.lli<)ll n:qucsb. pka.;l.' contac t me at :· oh:tllllt:.., lr.t 11**~.·p.J** gu\

Pa ge 23 of 25Eth a ltlur a lin Di e t a r

y Expos ure a nd Ri s k Assess m e nt

Eth n lnur a l in ( 1 131 0 1) Screening L evel lJ!'.1gc t \n alysis (SLU/\) Dar e : .Jun r I I , 2 0 1 5 What i s a Sc r <'c ni ng L c \' c l Usn g c An alysis (S L UA)? DP Numb er : 4320 16

i\vaibb(e estimates of pc!Sticid..: usag ..: data fnr a particular aeti\' 1.! ingredie nt that is used on ag ri c ultural cro p s in the Un it ed St:ues. • Pes ticide u sage data ob tained from various so urces . The data ar..: th..:n mag..:d,**~werugcd.** am i rounded so that th e presented inf o m1 :11io n is not prop ri ct:try. l'usine ss confidential. or tmd..: secre t. \ V

hat d ocs it co ntain ? • Pesticide u sage da ta fo r a !' in g le ac ti, ·c in gredient only. 1\gricultur:rlusc s it es (crops) th:tt the pt•sticidc is rep or ll'cl to be us..:d on. • Avai lable pcs ti ..:idc us:tge i nforma tion fwm 

## t : .s.**:.ta ..:~**  that prodw.:..: SO% or nwr..: ufa crop. in most c a ses. or less than XO %. in rare cases. depending on the scope o f the smv cy and a, ·;1i labl..:**rcs\lun.:c~ .**  • : \nnu:t l pcrccm o f crop trea t ed (an- ra ge & ma xi mum ) f o r ..:ad1 agri..:ultural ..:rop. • Average annual poun d s**oft~c** pe s ti cide applied fo r each**<~g iculturu** **l** crop (i
. e .. fur the s tates surve yed
. not for the entire Uni te d States)
. \\' h a t**as~ umpt** **io s**  c a n I m ake ahout t h e r e p o rt ed**d:tt :~'!**  •**nr a~e**  p o und s n f :H :I in • in g redi e nt app l ied ·**V:~lucs** arc calculnted by merging pesticide usage data so urces tugcthcr: a\'c raging aero:>!' allobsen ·a ti ons. then rounding. Nnre: !j TIH• t!Siimmt?d mlul' is lcss Than 500. tltt • nthat 1·aluc is lahl'il'd < 5110. f:stimwl'ti mlues hetll'een 501) & < I.OOIJ

. IJflflan• rounded to I si!!lli}icnnl digit

. Estimatt•d mlucs uf/

. llflf/ .1/IJO ur grea ta are mwul!'d 111 2 si:.:nificam digits.) • A n ra gc p e r ce nt of c r o p trea t ed · Values arc calcu l ated by merging data sources togethe r: a\ ..:raging b) year. a\'cmging across ull years. & rou nd ing to the nearest m u ltipl e of 5
. , \ ' n te: (f the estimated ml111' is le.u Than 2 5
. th (•ntlt l! mlue is laln·h·d ·. 2
. 5. (f I he < 'Slimmed ntluc is less them I then the I'Uiue i.\' lahelecl < I
. • ."\ l a x imum per ce nt u f cro p tr eat e d · Value is the s ingle maximum value reported acr oss u ll data sources . across all years . & roumk d up to th e r ll.:arcst multi pic n f 5. No t !': (f'tlte t'stimatcd ml11e i
.1 lcs. 1 11tan1. 5. Th en /h e wdut' is lahch·d < 1.5. Wha t ar c th e dat a so ur ces u s ed" ! • uS DA-N ASS ll'nitcd States Department 

## or i \ gricuhu rc · $ \'atiorwl Ag ricu lt u ral S tatistics Sen· ice}

-**pcsticid~·** u sage dnta fro m**~004** to 20 1 3
. • Pr intt c p es ti c ide rn a rk c t r cst' a rc h

- pc :s ticidc u::.ngc dn t <1 from**~004** to 2013. • C alif o r-nia D e p a rtment o f P es ti c ide Rej.\ulat io n ( OPJ{ ) P cs licid c**c** R c p o rtin l! ( P ti H ) data fnr ::!004 to 20 1::!. \\ ' h n t n r c th e limitnti o n s to th e data'! • Additional registered u ses may exis t bu t arc not inc luded becau s e the a\'ailablc sur\'cys do not rep o rt usag e (e.g
. . s ma ll ac rea ge**rop~).** • Lack o f reported usage**d<~ta** for the pesticide on a crop d ors n o t impl y /ern us: 1 ge . • Usngc d ata on a particular s it e may be n oted in data sources . but n o t qu a nt i fi ed
. In**th~sc** instance s . the site "ould not he rep orte d in the SU J A. • No n -ag ric uhural usc s ites (e
. g .. turf. post-han·c s t. mosquito co ntr o l. etc .) arc not reported in the SI. U :\
. /\ scparat ..: request must be m a de lll rccei, ·c these est i mat..: s. • Stmlc sites s h o w some usc. e\· cn though t hey arc n o t on the la be l.**Th i~**  usage c o u ld he due to \'Uriou s factors. including, but no t l imited to Section 18 reque s ts . exi sti ng s tock s of the chemical. data collection errors. a n d experimental usc permi ts (EuPs).

Pa ge 24 of25E thaiOuralin Dietary Expos ur e and Risk A ssess ment DPNumber: 4320 16

l>u tc: J unc 11 , 2015 Sc reen**in~** Level E s tim ate s 

## o r**A~ riculturul**  Uses 

## o r Ethnlflu ralin ( 1 1 3 1 0 I) Sorted A lphuh ctica ll y**Rcporli ~** **Year ~:** **200 ~-2** **0** 13
r-- 

# ____ ] - --= -1- l' c r ce nl

### C:**;Tre: ll** **~** f-
- A\ ' CrUJ!C A nnual
.

.**~~~-** Average Annual .\<l :u amum C rop s Lb s. : \

. 1. A., .,ll cd I A lf a lf n 9
. 000 < I 

## I < 2.5**~--4------------------------------ --------------** **------ --** **~** 13can s. Green · 6.0 00 5 25 I 

### .., ] C;}b b ag c ' < 500 < I 

# J <2.5 1**~** 

## - Canolu -1. 0 00 ' 

### < 2.5 f <2
. 5 1**~** -- 

# ------ -------- 5 Can taloupc:s
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