EX-10.4



 Exhibit 10.4 

FORM OF AMENDMENT, WAIVER AND CONSENT 

TO: INSITE VISION INCORPORATED (the “Corporation”) 

RE: 12% SECURED SENIOR NOTES OF THE CORPORATION 

WHEREAS: 
  

	A.	The undersigned (the “Holder”) is the holder of a 12% senior secured notes in the aggregate principal amount of US$             (the
“Holder Notes”, and together with all other notes issued pursuant to the Purchase Agreement (as defined below), the “Notes”) issued by the Corporation to the Holder pursuant to a securities purchase agreement (the
“Purchase Agreement”) dated as of October 9, 2014, as amended on November 21, 2014, by and among the Corporation, Riverbank Capital Securities, Inc., as placement agent, the Holder and certain other purchasers party
thereto. 

  

	B.	The Corporation, Ranbaxy, Inc., a subsidiary of Sun Pharmaceutical Industries Ltd. (“Ranbaxy”), and Thea Acquisition Corp., a subsidiary of Ranbaxy (“Merger Sub”), entered into an
agreement and plan of merger (the “Merger Agreement”) dated as of September 15, 2015 pursuant to which, among other things, Merger Sub will commence a cash tender offer (the “Offer”) for all outstanding shares
of common stock, par value $0.01 per share, of the Corporation at a purchase price of $0.35 per share, net to the seller in cash, without interest, followed by the merger of Merger Sub with and into the Corporation, with the Corporation being the
surviving corporation. 

  

	C.	Pursuant to the Merger Agreement, either party may terminate the Merger Agreement if the consummation of the Offer (the “Offer Closing”) does not occur on or before January 29, 2016, as it may be
extended by the parties pursuant to the terms of the Merger Agreement. 

  

	D.	Pursuant to Section 9(b) of the Notes, the consummation of the Offer will constitute a “Sale of Maker” as such term is defined in the Notes, and trigger an obligation of the Corporation to redeem (the
“Mandatory Redemption”) the Note at the Redemption Price, as defined in the Notes, within ten days after the consummation of the Offer. 

  

	E.	In connection with the Offer (i) Sun agreed to advance a loan (the “Sun Loan”) to the Corporation of up to US$11,914,194.52 on the terms and conditions of a secured note (the “Sun
Note”) issued by Corporation to Sun dated the date hereof and (ii) Sun, the Corporation and U.S. Bank National Association (the “Collateral Agent”), as collateral agent for the Holder and certain other purchasers under
the Purchase Agreement, entered into an intercreditor agreement (the “Intercreditor Agreement”) pursuant to which, among other things, the Collateral Agent agreed to subordinate the security interests (the “Holder’s
Security”) granted by the Corporation to secure its obligations under the Purchase Agreement pursuant to the terms of that certain Security Agreement, dated as of October 9, 2014 by the Corporation in favor of the Holder and certain
other purchasers under the Purchase Agreement and the Collateral Agent (the “Holder Security Agreement”) to the security interests granted by the Corporation to secure its obligations under the Sun Note (the “Sun
Security”) pursuant to the terms of that certain Security Agreement, dated the date hereof by the Corporation in favor of Sun (the “Sun Security Agreement”). 









	F.	The Holder, along with certain other holders of the Notes which together constitute the Majority Holders (as defined in the Purchase Agreement) wishes to provide its consent to amend the Notes to modify the maturity
date under the Notes, waive its rights pursuant to the Mandatory Redemption under the Notes and provide its consent to the Sun Loan and priority of the Sun Security on the terms and conditions hereof. 


THEREFORE, for valuable consideration, the receipt and sufficiency of which is hereby acknowledged, effective as of the date hereof, the Holder hereby
agrees as follows: 
  

	1.	Pursuant to Section 12 of the Notes, the Holder agrees to amend the Notes as follows: 

  

	 	(a)	Section 2 of the Notes is deleted in its entirety and replaced with the following: 


“2. Due Date. Unless earlier accelerated pursuant to the terms hereof, this Note matures and the outstanding principal balance of
this Note together with all accrued and unpaid interest hereunder becomes due and payable in a lump sum on the day (the “Maturity Date”) which is the earlier to occur of (i) the Closing Date, as such term is defined an
agreement and plan of merger dated as of September 15, 2015, entered into between the Maker, Ranbaxy, Inc., a subsidiary of Sun Pharmaceutical Industries Ltd., and Thea Acquisition Corp., a subsidiary of Ranbaxy Inc. (as such agreement may be
amended, restated and in effect from time to time, the “Merger Agreement”) and (ii) 12 months after the date on which the Merger Agreement is terminated.” 

 

	 	(b)	Section 5(B) of the Notes is deleted in its entirety and replaced with the following: 


(B) not, without the written consent of the Majority Holders (i) incur any indebtedness for money borrowed, other than indebtedness
(a) in an aggregate amount not to exceed $100,000, (b) owing to a seller incurred solely for the purpose of financing the purchase price of an asset of a type customarily purchased by the Maker acquired from such seller, (c) that is
subordinated to this Note in a manner reasonably satisfactory to the Holder or (d) owing to Ranbaxy or any of its affiliates or assigns or (ii) grant, or permit to be created, any lien other than the security interests created under the
Security Agreement and any security interest which would constitute a Permitted Lien (as defined in the Security Agreement); 
  

	2.	Pursuant to Section 12 of the Notes, the Holder, along with certain other holders of the Notes which together constitute the Majority Holders (as defined in the Purchase Agreement), hereby irrevocably and
unconditionally waives all of the rights of the holders of the Notes pursuant to the Mandatory Redemption in connection with the Offer and the Merger Agreement, and agrees that, notwithstanding any other provision of the Notes, the Offer and any
transaction contemplated under the Merger Agreement shall be deemed not to constitute a “Sale of Maker”, as such term is defined under the Notes. 


 

	3.	 Pursuant to Section 5 of the Notes, the Holder, along with certain other holders of the Notes which together constitute the Majority Holders,
hereby irrevocably and 



  
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unconditionally consents to the Sun Loan on the terms and conditions of the Sun Note, the entering into the Sun Security Agreement and granting of the Sun Security and the subordination of the
Holder’s Security to the Sun Security on the terms and conditions of the Intercreditor Agreement, and agrees that, notwithstanding any other provision of the Notes or the Purchase Agreement, the Sun Note, the Intercreditor Agreement and any one
or more transactions contemplated thereby shall be deemed not to constitute and Event of Acceleration, as such term is defined in the Notes. 

  

	4.	Holder, along with certain other holders of the Notes which together constitute the Majority Holders, hereby instructs Collateral Agent to execute the Intercreditor Agreement substantially in the form set out in
Exhibit A hereto. 

  

	5.	The Holder represents and warrants that as of the date hereof: (i) it is the sole registered and beneficial owner of the Holder Notes, free and clear of all encumbrances, and that it has not transferred or in any
way disposed of any of its rights under the Holder Notes or any portion thereof; and (ii) no Event of Acceleration, as such term is defined in the Holder Notes, has occurred and is continuing. 


 

	6.	The Holder acknowledges and understands that the Corporation is relying on this amendment, waiver and consent in connection with the entering into the Merger Agreement and performance of its obligations thereunder.


  

	7.	Time is the essence of this amendment, waiver and consent. 

  

	8.	Except as amended or supplemented by this amendment, waiver and consent, the Notes remain unchanged and in full force and effect. This amendment, waiver and consent shall be governed by the laws of the State of New
York. 

  

	9.	If any provision of this amendment, waiver and consent is held invalid or unenforceable by any court of competent jurisdiction, the other provisions of this amendment, waiver and consent shall remain in full force and
effect. Any provision of this amendment, waiver and consent held invalid only in part or degree shall remain in full force and effect to the extent not held invalid or unenforceable. 


 

	10.	This amendment, waiver and consent shall be binding upon and shall inure to the benefit of the Holder and the Corporation and their respective successors and permitted assigns. 


 

	11.	This amendment, waiver and consent may be executed in several counterparts (including by facsimile or other electronic means including .pdf), each of which when so executed shall be deemed to be an original and shall
have the same force and effect as an original, and such counterparts together shall constitute one and the same instrument. 

  

	12.	The Corporation and the Holder acknowledge that the indemnities and reimbursement provisions of the Holder Security Agreement and the other Collateral Documents (as defined in the Holder Security Agreement) apply to the
transactions contemplated by this amendment, waiver and consent. 

 [Signature page follows] 

  
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 IN WITNESS WHEREOF, the Holder has duly executed this amendment, waiver and consent on the
15th day of September, 2015. 
  

	
	  

	Name:


 [SIGNATURE PAGE TO AMENDMENT, WAIVER AND CONSENT] 







 The Corporation has agreed to and accepted this amendment, waiver and consent on the 15th day of
September, 2015. 
  

			
	INSITE VISION INCORPORATED by its authorized signatory:
		
		 	  

		 	Authorized Signatory
		 	Name: Timothy M. Ruane
		 	Title: Chief Executive Officer


 [SIGNATURE PAGE TO AMENDMENT, WAIVER AND CONSENT] 







 Exhibit A 

INTERCREDITOR AGREEMENT 

Intercreditor Agreement (this “Agreement”), dated as of September 15, 2015, among Ranbaxy, Inc., as secured party (in
such capacity, with its successors and assigns, and as more specifically defined below, the “First Priority Creditor”) for the First Priority Secured Parties (as defined below), U.S. BANK NATIONAL ASSOCIATION, as
collateral agent (in such capacity, with its successors and assigns, and as more specifically defined below, the “Second Priority Representative”) for the Second Priority Secured Parties (as defined below) and INSITE
VISION INCORPORATED (the “Company”). 
 WHEREAS, the Company and the First Priority Creditor are parties to the
Secured Note, dated as of September 15, 2015 (the “Existing First Priority Agreement”), pursuant to which the First Priority Creditor agreed to make advances to the Company; and 

WHEREAS, the Company, Riverbank Capital Securities, Inc., as placement agent and the purchasers party thereto are parties to the Securities
Purchase Agreement, dated as of October 9, 2014 (and as amended on November 21, 2014) (the “Existing Second Priority Agreement”), pursuant to which the Company has issued secured notes (the “Second-Lien Notes”); and 
 WHEREAS, the Company has granted to the First Priority Creditor
security interests in the Common Collateral as security for payment and performance of the First Priority Obligations; and 
 WHEREAS,
the Company has granted to the Second Priority Representative security interests in the Common Collateral as security for payment and performance of the Second Priority Obligations and the Second Priority Representative, on behalf of
the Second Priority Secured Parties, is hereby agreeing to subordinate such security interests, at the direction of the required holders of the Second Lien Notes, to the security interest of the First Priority Creditor; 

NOW THEREFORE, in consideration of the foregoing and the mutual covenants herein contained and other good and valuable consideration, the
existence and sufficiency of which are expressly recognized by all of the parties hereto, the parties agree as follows: 
 SECTION 1.
Definitions. 
 1.1. Defined Terms. The following terms, as used herein, have the following meanings: 

“Agreement” has the meaning set forth in the introductory paragraph hereof. 

“Bankruptcy Code” means the United States Bankruptcy Code (11 U.S.C. §101 et seq.), as amended from time to time. 

“Common Collateral” means all assets that are both First Priority Collateral and Second Priority Collateral. 







 “Company” has the meaning set forth in the introductory paragraph hereof. 

“Comparable Second Priority Security Document” means, in relation to any Common Collateral subject to any
First Priority Security Document, that Second Priority Security Document that creates a security interest in the same Common Collateral, granted by the Company. 

“DIP Financing” has the meaning set forth in Section 5.2. 

“Enforcement Action” means, with respect to the First Priority Obligations or the Second Priority Obligations, the
exercise of any rights and remedies with respect to any Common Collateral securing such obligations or the commencement or prosecution of enforcement of any of the rights and remedies with respect to the Common Collateral under, as applicable, the
First Priority Documents or the Second Priority Documents, or applicable law, including without limitation the exercise of any rights of set-off or recoupment, and the exercise of any rights or
remedies of a secured creditor under the Uniform Commercial Code of any applicable jurisdiction or under the Bankruptcy Code. 

“Existing First Priority Agreement” has the meaning set forth in the first WHEREAS clause of this Agreement.

 “Existing Second Priority Agreement” has the meaning set forth in the second WHEREAS clause of this
Agreement. 
 “First Priority Agreement” means the collective reference to (a) the Existing First Priority
Agreement and (b) any other credit agreement, loan agreement, note agreement, promissory note, indenture or other agreement or instrument evidencing or governing the terms of any indebtedness or other financial accommodation that has been
incurred to extend, increase, renew, refund, replace (whether upon or after termination or otherwise) or refinance (including by means of sales of debt securities to institutional investors) in whole or in part from time to time the indebtedness and
other obligations outstanding under the Existing First Priority Agreement or any other agreement or instrument referred to in this clause (b) unless such agreement or instrument expressly provides that it is not intended to be and is not a
First Priority Agreement hereunder (a “Replacement First Priority Agreement”). Any reference to the First Priority Agreement hereunder shall be deemed a reference to any First Priority Agreement then extant. 

“First Priority Collateral” means all assets, whether now owned or hereafter acquired by the Company, in which a Lien is
granted or purported to be granted to any First Priority Secured Party as security for any First Priority Obligation. 

“First Priority Creditor” means Ranbaxy, Inc. or any Persons that become holders or lenders under a First Priority
Agreement from time to time. 
 “First Priority Documents” means the First Priority Agreement and each
First Priority Security Document. 

  
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 “First Priority Lien” means any Lien created by the First Priority
Security Documents. 
 “First Priority Obligations” means (a) with respect to the Existing First Priority
Agreement, all “Secured Obligations” of the Company as defined in the First Priority Security Documents and (b) with respect to each other First Priority Agreement, (i) all principal of and interest (including without
limitation any Post-Petition Interest) and premium (if any) on all loans made or other indebtedness issued or incurred pursuant to the First Priority Agreement and (ii) all guarantee obligations,
fees, expenses and other amounts payable from time to time pursuant to the First Priority Documents, in each case whether or not allowed or allowable in an Insolvency Proceeding. To the extent any payment with respect to any First Priority
Obligation (whether by or on behalf of the Company, as proceeds of security, enforcement of any right of setoff or otherwise) is declared to be a fraudulent conveyance or a preference in any respect, set aside or required to be paid to a debtor in
possession, any Second Priority Secured Party, receiver or similar Person, then the obligation or part thereof originally intended to be satisfied shall, for the purposes of this Agreement and the rights and obligations of the
First Priority Secured Parties and the Second Priority Secured Parties, be deemed to be reinstated and outstanding as if such payment had not occurred. 

“First Priority Obligations Payment Date” means the first date on which (a) the First Priority
Obligations (other than those that constitute Unasserted Contingent Obligations) have been paid in full (or cash collateralized or defeased in a manner reasonably satisfactory to the First Priority Creditor), (b) all commitments to extend
credit under the First Priority Documents have been terminated and (c) the First Priority Creditor has delivered a written notice to the Second Priority Representative stating that the events described in clauses (a) and
(b) have occurred to the satisfaction of the First Priority Secured Parties, which notice shall be delivered by the First Priority Creditor promptly after the occurrence of the events described in clauses (a) and (b). 

“First Priority Secured Parties” means the First Priority Creditor and any other holders of the First Priority
Obligations. 
 “First Priority Security Documents” means the “Security Agreement” as defined in the
First Priority Agreement, and any other documents pursuant to which a Lien is granted to the First Priority Creditor for the benefit of the First Priority Secured Parties. 

“Insolvency Proceeding” means any proceeding in respect of bankruptcy, insolvency, winding up, receivership, dissolution or
assignment for the benefit of creditors, in each of the foregoing events whether under the Bankruptcy Code or any similar federal, state or foreign bankruptcy, insolvency, reorganization, receivership or similar law. 

“Lien” means any mortgage, pledge, security interest, encumbrance, lien or charge of any kind (including any agreement to
give any of the foregoing, any conditional sale or other title retention agreement or any lease in the nature thereof). 
 “Merger
Agreement” means that certain Agreement and Plan of Merger, of even date herewith, by and among the First Priority Creditor, Thea Acquisition Corp., a Delaware corporation and the Company, as it may be amended from time to time in
accordance with the terms thereof. 

  
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 “Merger” has the meaning set forth in the Merger Agreement. 

“Person” means any person, individual, sole proprietorship, partnership, joint venture, corporation, limited liability
company, unincorporated organization, association, institution, entity, party, including any government and any political subdivision, agency or instrumentality thereof. 

“Post-Petition Interest” means any interest or entitlement to fees or expenses or
other charges that accrues after the commencement of any Insolvency Proceeding, whether or not allowed or allowable in any such Insolvency Proceeding. 

“Real Property” means any right, title or interest in and to real property, including any fee interest, leasehold interest,
easement, or license and any other right to use or occupy real property, including any right arising by contract. 
 “Replacement
First Priority Agreement” has the meaning set forth in the definition of “First Priority Agreement.” 

“Second-Lien Notes” has the meaning set forth in the second WHEREAS
clause of this Agreement. 
 “Second Priority Agreement” means the collective reference to (a) the Existing
Second Priority Agreement and (b) any other credit agreement, loan agreement, note agreement, promissory note, indenture, or other agreement or instrument evidencing or governing the terms of any indebtedness or other financial
accommodation that has been incurred to extend, increase, renew, refund, replace (whether upon or after termination or otherwise) or refinance (including by means of sales of debt securities to institutional investors) in whole or in part from time
to time the indebtedness and other obligations outstanding under the Existing Second Priority Agreement or any other agreement or instrument referred to in this clause (b). Any reference to the Second Priority Agreement hereunder
shall be deemed a reference to any Second Priority Agreement then extant. 
 “Second Priority Collateral” means
all assets, whether now owned or hereafter acquired by the Company, in which a Lien is granted or purported to be granted to any Second Priority Secured Party as security for any Second Priority Obligation. 

“Second Priority Creditors” means the “Holders” as defined in the Second Priority Agreement and any
holder of a Second-Lien Note and the Second Priority Representative. 

“Second Priority Documents” means each Second Priority Agreement and each Second Priority Security Document.

 “Second Priority Lien” means any Lien created by the Second Priority Security Documents. 

  
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 “Second Priority Obligations” means (a) with respect to the Existing
Second Priority Agreement, all “Secured Obligations” as defined in the Second Priority Security Documents and (b) with respect to each other Second Priority Agreement, (i) all principal of and interest (including
without limitation any Post-Petition Interest) and premium (if any) on all indebtedness under the Second Priority Agreement, and (ii) all guarantee obligations, fees, expenses and other amounts
payable from time to time pursuant to the Second Priority Documents, in each case whether or not allowed or allowable in an Insolvency Proceeding. To the extent any payment with respect to any Second Priority Obligation (whether by or on
behalf of the Company, as proceeds of security, enforcement of any right of setoff or otherwise) is declared to be a fraudulent conveyance or a preference in any respect, set aside or required to be paid to a debtor in possession, any
First Priority Secured Party, receiver or similar Person, then the obligation or part thereof originally intended to be satisfied shall, for the purposes of this Agreement and the rights and obligations of the First Priority Secured
Parties and the Second Priority Secured Parties, be deemed to be reinstated and outstanding as if such payment had not occurred. 

“Second Priority Representative” has the meaning set forth in the introductory paragraph hereof, but shall also include
any Person identified as a “Second Priority Representative” in any Second Priority Agreement other than the Existing Second Priority Agreement. 

“Second Priority Secured Parties” means the Second Priority Representative, the Second Priority Creditors and
any other holders of the Second Priority Obligations. 
 “Second Priority Security Documents” means the
“Security Agreement” as defined in the Second Priority Agreement and any other documents pursuant to which a Lien is granted to the Second Priority Representative for the benefit of the Second Priority Secured Parties. 

“Secured Parties” means the First Priority Secured Parties and the Second Priority Secured Parties. 

“Standstill Period” has the meaning set forth in Section 3.2. 

“Sun Default” means the termination of the Merger Agreement by the Company pursuant to Section 8.1(f) thereof. 

“Unasserted Contingent Obligations” shall mean, at any time, First Priority Obligations for taxes, costs,
indemnifications, reimbursements, damages and other liabilities (excluding the principal of, and interest and premium (if any) on, and fees and expenses relating to, any First Priority Obligation) in respect of which no assertion of liability
(whether oral or written) and no claim or demand for payment (whether oral or written) has been made (and, in the case of First Priority Obligations for indemnification, no notice for indemnification has been issued by the indemnitee) at such
time. 
 “Uniform Commercial Code” shall mean the Uniform Commercial Code as in effect from time to time in the applicable
jurisdiction. 

  
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 1.2. Terms Generally. The definitions of terms herein shall apply equally to the singular
and plural forms of the terms defined. Whenever the context may require, any pronoun shall include the corresponding masculine, feminine and neuter forms. The words “include”, “includes” and “including” shall be deemed
to be followed by the phrase “without limitation”. The word “will” shall be construed to have the same meaning and effect as the word “shall”. Unless the context requires otherwise (i) any definition of or
reference to any agreement, instrument or other document herein shall be construed as referring to such agreement, instrument or other document as from time to time amended, restated, supplemented or otherwise modified, (ii) any reference
herein to any Person shall be construed to include such Person’s successors or permitted assigns, (iii) the words “herein”, “hereof” and “hereunder”, and words of similar import, shall be construed to refer to
this Agreement in its entirety and not to any particular provision hereof, (iv) all references herein to Sections shall be construed to refer to Sections of this Agreement and (v) the words “asset” and “property” shall
be construed to have the same meaning and effect and to refer to any and all tangible and intangible assets and properties, including cash, securities, accounts and contract rights. 

SECTION 2. Lien Priorities. 

2.1. Subordination of Liens. (a) Any and all Liens now existing or hereafter created or arising in favor of any
Second Priority Secured Party securing the Second Priority Obligations, regardless of how acquired, whether by grant, statute, operation of law, subrogation or otherwise are expressly junior in priority, operation and effect to any and all
Liens now existing or hereafter created or arising in favor of the First Priority Secured Parties securing the First Priority Obligations, notwithstanding (i) anything to the contrary contained in any agreement or filing to which any
Second Priority Secured Party may now or hereafter be a party, and regardless of the time, order or method of grant, attachment, recording or perfection of any financing statements or other security interests, assignments, pledges, deeds,
mortgages and other liens, charges or encumbrances or any defect or deficiency or alleged defect or deficiency in any of the foregoing, (ii) any provision of the Uniform Commercial Code or any applicable law or any First Priority Document
or Second Priority Document or any other circumstance whatsoever and (iii) the fact that any such Liens in favor of any First Priority Secured Party securing any of the First Priority Obligations are (x) subordinated to any
Lien securing any obligation of the Company other than the Second Priority Obligations or (y) otherwise subordinated, voided, avoided, invalidated or lapsed. 

(a) No First Priority Secured Party or Second Priority Secured Party shall object to or contest, or support any other
Person in contesting or objecting to, in any proceeding (including without limitation, any Insolvency Proceeding), the validity, extent, perfection, priority or enforceability of any security interest in the Common Collateral granted to the other.
Notwithstanding any failure by any First Priority Secured Party or Second Priority Secured Party to perfect its security interests in the Common Collateral or any avoidance, invalidation or subordination by any third party or court of
competent jurisdiction of the security interests in the Common Collateral granted to the First Priority Secured Parties or the Second Priority Secured parties, the priority and rights as between the First Priority Secured Parties and
the Second Priority Secured Parties with respect to the Common Collateral shall be as set forth herein. 

  
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 2.2. Nature of First Priority Obligations. The Second Priority Representative on
behalf of itself and the other Second Priority Secured Parties acknowledges that the terms of the First Priority Obligations may be modified, extended or amended from time to time, and that the aggregate amount of the First Priority
Obligations may be increased, replaced or refinanced, in each event, without notice to or consent by the Second Priority Secured Parties and without affecting the provisions hereof. The lien priorities provided in Section 2.1 shall
not be altered or otherwise affected by any such amendment, modification, supplement, extension, repayment, reborrowing, increase, replacement, renewal, restatement or refinancing of either the First Priority Obligations or the
Second Priority Obligations, or any portion thereof. 
 2.3. Agreements Regarding Actions to Perfect Liens. (b) The
Second Priority Representative on behalf of itself and the other Second Priority Secured Parties agrees that UCC-1 financing statements, patent, trademark or copyright filings or other filings or
recordings filed or recorded by or on behalf of the Second Priority Representative, subsequent to the date hereof, shall be in form satisfactory to the First Priority Creditor. 

(a) The Second Priority Representative agrees on behalf of itself and the other Second Priority Secured Parties that
all mortgages, deeds of trust, deeds and similar instruments (collectively, “mortgages”) now or hereafter filed against Real Property that constitutes Common Collateral in favor of or for the benefit of the Second Priority
Representative and the other Second Priority Secured Parties shall be in form satisfactory to the First Priority Creditor and shall contain the following notation: “The lien created by this mortgage on the property described herein is
junior and subordinate to the lien on such property created by any mortgage, deed of trust or similar instrument now or hereafter granted to the First Priority Creditor, and its successors and assigns, in such property, in accordance with the
provisions of the Intercreditor Agreement dated as of September [●], 2015 among Ranbaxy, Inc., U.S. Bank National Association and InSite Vision Incorporated, as amended from time to time.” 

(b) The First Priority Creditor hereby acknowledges that, to the extent that it holds, or a third party holds on its
behalf, physical possession of or “control” (as defined in the Uniform Commercial Code) over Common Collateral pursuant to the First Priority Security Documents, such possession or control is also for the benefit of and on behalf of,
and the First Priority Creditor or such third party holds such possession or control as bailee and agent for, the Second Priority Representative and the other Second Priority Secured Parties solely to the extent required to perfect
their security interest in such Common Collateral (such bailment and agency for perfection being intended, among other things, to satisfy the requirements of Sections 8-301(a)(2) and 9-313(c) of the Uniform Commercial Code). Nothing in the preceding sentence shall be construed to impose any duty on the First Priority Creditor (or any third party acting on its behalf) with respect to such
Common Collateral or provide the Second Priority Representative or any other Second Priority Secured Party with any rights with respect to such Common Collateral beyond those specified in this Agreement and the Second Priority
Security Documents, provided that subsequent to the occurrence of the First Priority Obligations Payment Date, the First Priority Creditor shall (i) deliver to the Second Priority Representative, at the Company’s sole
cost and expense, the Common Collateral in its possession or control together with any necessary endorsements to the 

  
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extent required by the Second Priority Documents (and to the extent not so required, such delivery shall be made to the Company) or (ii) direct and deliver such Common Collateral as a
court of competent jurisdiction otherwise directs, and provided, further, that the provisions of this Agreement are intended solely to govern the respective Lien priorities as between the First Priority Secured Parties and the
Second Priority Secured Parties and shall not impose on the First Priority Secured Parties any obligations in respect of the disposition of any Common Collateral (or any proceeds thereof) that would conflict with prior perfected Liens or
any claims thereon in favor of any other Person that is not a Secured Party. 
 2.4. No New Liens. So long as the First Priority
Obligations Payment Date has not occurred, the parties hereto agree that (a) neither the Company nor any of its subsidiaries shall have any right to create any Lien, on any assets of the Company or any such subsidiary securing any
Second Priority Obligation and (b) if any Second Priority Secured Party shall acquire or hold any Lien on any assets of the Borrower securing any Second Priority Obligation which assets are not also subject to the first-priority Lien of the First Priority Creditor under the First Priority Documents, then the Second Priority Representative, upon demand by the First Priority Creditor, will without the need
for any further consent of any other Second Priority Secured Party, notwithstanding anything to the contrary in any other Second Priority Document either (i) release such Lien or (ii) assign it to the First Priority Creditor
as security for the First Priority Obligations (in which case the Second Priority Representative may retain a junior lien on such assets subject to the terms hereof). To the extent that the foregoing provisions are not complied with for
any reason, without limiting any other rights and remedies available to the First Priority Secured Parties, the Second Priority Representative and the other Second Priority Secured Parties agree that any amounts received by or
distributed to any of them pursuant to or as a result of Liens granted in contravention of this Section 2.4 shall be subject to Section 4.1. 

SECTION 3. Enforcement Rights. 

3.1. Exclusive Enforcement. Until the First Priority Obligations Payment Date has occurred, whether or not an Insolvency Proceeding
has been commenced by or against the Company, the First Priority Creditor shall have the exclusive right to take and continue any Enforcement Action with respect to the Common Collateral, without any consultation with or consent of any
Second Priority Secured Party, but subject to the provisos set forth in Sections 3.2 and 5.1. Upon the occurrence and during the continuance of a default or an event of acceleration under the First Priority Documents,
the First Priority Creditor and the other First Priority Secured Parties may take and continue any Enforcement Action with respect to the First Priority Obligations and the Common Collateral in such order and manner as they may
determine in their sole discretion. 
 3.2. Standstill and Waivers. The Second Priority Representative, on behalf of itself and
the other Second Priority Secured Parties, and the Second Priority Secured Parties, agree that, until the First Priority Obligations Payment Date has occurred, subject to the proviso set forth in Section 5.1: 

(a) they will not take or cause to be taken any Enforcement Action; 

  
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 (b) they will not take or cause to be taken any action, the purpose or effect of
which is to make any Lien in respect of any Second Priority Obligation pari passu with or senior to, or to give any Second Priority Secured Party any preference or priority relative to, the Liens with respect to the First Priority
Obligations or the First Priority Secured Parties with respect to any of the Common Collateral; 
 (c) they will not
contest, oppose, object to, interfere with, hinder or delay, in any manner, whether by judicial proceedings (including without limitation the filing of an Insolvency Proceeding) or otherwise, any foreclosure, sale, lease, exchange, transfer or other
disposition of the Common Collateral by any First Priority Secured Party or any other Enforcement Action taken (or any forbearance from taking any Enforcement Action) by or on behalf of any First Priority Secured Party; 

(d) they have no right to (i) direct either the First Priority Creditor or any other First Priority Secured
Party to exercise any right, remedy or power with respect to the Common Collateral or pursuant to the First Priority Security Documents or (ii) consent or object to the exercise by the First Priority Creditor or any other
First Priority Secured Party of any right, remedy or power with respect to the Common Collateral or pursuant to the First Priority Security Documents or to the timing or manner in which any such right is exercised or not exercised (or, to
the extent they may have any such right described in this clause (d), whether as a junior lien creditor or otherwise, they hereby irrevocably waive such right); 

(e) they will not institute any suit or other proceeding or assert in any suit, Insolvency Proceeding or other proceeding any
claim against any First Priority Secured Party seeking damages from or other relief by way of specific performance, injunction or otherwise, with respect to, and no First Priority Secured Party shall be liable for, any action taken or
omitted to be taken by any First Priority Secured Party with respect to the Common Collateral or pursuant to the First Priority Documents; 

(f) they will not seek, and hereby waive any right, to have the Common Collateral or any part thereof marshaled upon any
foreclosure or other disposition of the Common Collateral; 
 (g) they will not make any judicial or non-judicial claim or demand or commence any judicial or non-judicial proceedings against the Company or any of its subsidiaries or affiliates under or with respect to any
Second Priority Security Document seeking payment or damages from or other relief by way of specific performance, instructions or otherwise under or with respect to any Second Priority Security Document (other than filing a proof of claim)
or exercise any right, remedy or power under or with respect to, or otherwise take any action to enforce (other than filing a proof of claim and other filings and making any arguments and motions that are necessary to preserve their rights with
respect to the Second Priority Obligations and the Common Collateral) any Second Priority Security Document; and 

(h) they will not commence judicial or non-judicial foreclosure proceedings with
respect to, seek to have a trustee, receiver, liquidator or similar official 

  
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appointed for or over, attempt any action to take possession of any Common Collateral, exercise any right, remedy or power with respect to, or otherwise take any action to enforce their interest
in or realize upon, the Common Collateral or pursuant to the Second Priority Security Documents; 
 provided that, notwithstanding the
foregoing, any Second Priority Secured Party may exercise its rights and remedies in respect of the Common Collateral under the Second Priority Security Documents or applicable law after the passage of a period of 180 days (the
“Standstill Period”) from the date of delivery of a notice in writing to the First Priority Creditor of its intention to exercise such rights and remedies, which notice may only be delivered following the occurrence of and
during the continuation of an “Event of Acceleration” under and as defined in the Second Priority Agreement; provided, further, however, that, notwithstanding the foregoing, in no event shall any
Second Priority Secured Party exercise or continue to exercise any such rights or remedies if, notwithstanding the expiration of the Standstill Period, (i) any First Priority Secured Party shall have commenced and be diligently
pursuing the exercise of any of its rights and remedies with respect to any of the Common Collateral (prompt notice of such exercise to be given to the Second Priority Representative by such First Priority Secured Party) or (ii) an
Insolvency Proceeding in respect of the Company shall have been commenced; and provided, further, that in any Insolvency Proceeding commenced by or against the Company, the Second Priority Representative and the
Second Priority Secured Parties may take any action expressly permitted by Section 5. 
 3.3. Judgment Creditors. In
the event that any Second Priority Secured Party becomes a judgment lien creditor as a result of its enforcement of its rights as an unsecured creditor, any such judgment lien shall be subject to the terms of this Agreement for all purposes
(including in relation to the First Priority Liens and the First Priority Obligations) to the same extent as other Liens securing the Second Priority Obligations are subject to the terms of this Agreement. 

3.4. Cooperation. The Second Priority Representative, on behalf of itself and the other Second Priority Secured Parties and
at the sole cost and expense of the Company, agrees that each of them shall take such actions as the First Priority Creditor shall request in connection with the exercise by the First Priority Secured Parties of their rights set forth
herein. 
 3.5. No Additional Rights For the Company Hereunder. Except as provided in Section 3.6, if any
First Priority Secured Party or Second Priority Secured Party shall enforce its rights or remedies in violation of the terms of this Agreement, the Company shall not be entitled to use such violation as a defense to any action by any
First Priority Secured Party or Second Priority Secured Party, nor to assert such violation as a counterclaim or basis for set off or recoupment against any First Priority Secured Party or Second Priority Secured Party. 

3.6. Actions Upon Breach. (c) If any Second Priority Secured Party, contrary to this Agreement, commences or participates in
any action or proceeding against the Company or the Common Collateral, the Company, with the prior written consent of the First Priority Secured Representative, may interpose as a defense or dilatory plea the making of this Agreement, and any
First Priority Secured Party may intervene and interpose such defense or plea in its or their name or in the name of the Company. 

  
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 (a) Should any Second Priority Secured Party, contrary to this Agreement, in
any way take, attempt to or threaten to take any action with respect to the Common Collateral (including, without limitation, any attempt to realize upon or enforce any remedy with respect to this Agreement), or fail to take any action required by
this Agreement, any First Priority Secured Party (in its own name or in the name of the Company) or the Company may obtain relief against such Second Priority Secured Party by injunction, specific performance and/or other appropriate
equitable relief, it being understood and agreed by the Second Priority Representative on behalf of each Second Priority Secured Party that (i) the First Priority Secured Parties’ damages from its actions may at that time be
difficult to ascertain and may be irreparable, and (ii) each Second Priority Secured Party waives any defense that the Company and/or the First Priority Secured Parties cannot demonstrate damage and/or be made whole by the awarding of
damages. 
 SECTION 4. Application of Proceeds of Common Collateral; Dispositions and Releases of Common Collateral; Inspection and
Insurance. 
 4.1. Application of Proceeds; Turnover Provisions. All proceeds of Common Collateral (including without limitation
any interest earned thereon) resulting from the sale, collection or other disposition of Common Collateral in connection with an Enforcement Action, whether or not pursuant to an Insolvency Proceeding, shall be distributed as follows:
first to the First Priority Creditor for application to the First Priority Obligations in accordance with the terms of the First Priority Documents, until the First Priority Obligations Payment Date has occurred and
thereafter, to the Second Priority Representative for application in accordance with the Second Priority Documents. Until the occurrence of the First Priority Obligations Payment Date, any Common Collateral, including without
limitation any such Common Collateral constituting proceeds, that may be received by any Second Priority Secured Party in violation of this Agreement shall be segregated and held in trust and promptly paid over to the First Priority
Creditor, for the benefit of the First Priority Secured Parties, in the same form as received, with any necessary endorsements, and each Second Priority Secured Party hereby authorizes the First Priority Creditor to make any such
endorsements as agent for the Second Priority Representative (which authorization, being coupled with an interest, is irrevocable). 

4.2. Releases of Second Priority Lien. (d) Upon any release, sale or disposition of Common Collateral permitted pursuant to
the terms of the First Priority Documents that results in the release of the First Priority Lien on any Common Collateral (excluding (i) any sale or other disposition that is expressly prohibited by the Second Priority Agreement
unless such sale or disposition is consummated in connection with an Enforcement Action or consummated after the institution of any Insolvency Proceeding and (ii) the release of all First Priority Liens after the occurrence of the
First Priority Obligations Payment Date), the Second Priority Lien on such Common Collateral (excluding any portion of the proceeds of such Common Collateral remaining after the First Priority Obligations Payment Date occurs) shall be
automatically and unconditionally released with no further consent or action of any Person, except that the First Priority Creditor shall have notified the Second Priority Representative of such release. 

  
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 (a) The Second Priority Representative shall, upon the direction of the
required holders of the Second Lien Notes, promptly execute and deliver such release documents and instruments at the expense of the Company and shall take such further actions as the First Priority Creditor shall request to evidence any
release, without representation, warranty or recourse, express or implied, of the Second Priority Lien described in paragraph (a) at the expense of the Company. The Second Priority Representative hereby appoints the
First Priority Creditor and any officer or duly authorized person of the First Priority Creditor, with full power of substitution, as its true and lawful
attorney-in-fact with full irrevocable power of attorney in the place and stead of the Second Priority Representative and in the name of the Second Priority
Representative or in the First Priority Creditor’s own name, from time to time, in the First Priority Creditor’s sole discretion, for the purposes of carrying out the terms of this Section 4.2, to take any and all
appropriate action and to execute and deliver any and all documents and instruments as may be necessary or desirable to accomplish the purposes of this Section 4.2, including, without limitation, any financing statements, endorsements,
assignments, releases or other documents or instruments of transfer (which appointment, being coupled with an interest, is irrevocable). 

4.3. Inspection Rights and Insurance. (e) Any First Priority Secured Party and its representatives and invitees may at any
time inspect, repossess, remove and otherwise deal with the Common Collateral, and the First Priority Creditor may advertise and conduct public auctions or private sales of the Common Collateral, in each case without notice to, the involvement
of or interference by any Second Priority Secured Party or liability to any Second Priority Secured Party. 
 (a)
Until the First Priority Obligations Payment Date has occurred, the First Priority Creditor will have the sole and exclusive right (i) to be named as additional insured and loss payee under any insurance policies maintained from time
to time by the Company (except that the Second Priority Representative shall have the right to be named as additional insured and loss payee so long as its second lien status is identified in a manner satisfactory to the
First Priority Creditor); (ii) to adjust or settle any insurance policy or claim covering the Common Collateral in the event of any loss thereunder and (iii) to approve any award granted in any condemnation or similar proceeding
affecting the Common Collateral. 
 SECTION 5. Insolvency Proceedings. 

5.1. Filing of Motions. Until the First Priority Obligations Payment Date has occurred, the Second Priority Representative
agrees on behalf of itself and the other Second Priority Secured Parties that no Second Priority Secured Party shall, in or in connection with any Insolvency Proceeding, file any pleadings or motions, take any position at any hearing or
proceeding of any nature, or otherwise take any action whatsoever, in each case that (a) violates, or is prohibited by, this Section 5 (or, in the absence of an Insolvency Proceeding, otherwise would violate or be prohibited by this
Agreement), (b) asserts any right, benefit or privilege that arises in favor of the Second Priority Representative or Second Priority Secured Parties, in whole or in part, as a result of their interest in the Common Collateral or in
the Second Priority Lien (unless the assertion of such right is expressly permitted by this Agreement) 

  
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or (c) challenges the validity, priority, enforceability or voidability of any Liens or claims held by the First Priority Creditor or any other First Priority Secured Party with
respect to the Common Collateral, or the extent to which the First Priority Obligations constitute secured claims or the value thereof under Section 506(a) of the Bankruptcy Code or otherwise; provided that the Second Priority
Representative may file a proof of claim in an Insolvency Proceeding, subject to the limitations contained in this Agreement and only if consistent with the terms and the limitations on the Second Priority Representative imposed hereby. 

5.2. Financing Matters. If the Company becomes subject to any Insolvency Proceeding, and if the First Priority Creditor or the
other First Priority Secured Parties desire to consent (or not object) to the use of cash collateral under the Bankruptcy Code or to provide financing to the Company under the Bankruptcy Code or to consent (or not object) to the provision of
such financing to the Company by any third party (any such financing, “DIP Financing”), then the Second Priority Representative agrees, on behalf of itself and the other Second Priority Secured Parties, that each
Second Priority Secured Party (a) will be deemed to have consented to, will raise no objection to, nor support any other Person objecting to, the use of such cash collateral or to such DIP Financing, (b) will not request or accept
adequate protection or any other relief in connection with the use of such cash collateral or such DIP Financing except as set forth in Section 5.4 below, (c) will subordinate (and will be deemed hereunder to have subordinated) the
Second Priority Liens on any Common Collateral (i) to such DIP Financing on the same terms as the First Priority Liens are subordinated thereto (and such subordination will not alter in any manner the terms of this Agreement),
(ii) to any adequate protection provided to the First Priority Secured Parties and (iii) to any “carve-out” agreed to by the First Priority Creditor or the other
First Priority Secured Parties, and (d) agrees that notice received two calendar days prior to the entry of an order approving such usage of cash collateral or approving such financing shall be adequate notice. 

5.3. Relief From the Automatic Stay. The Second Priority Representative agrees, on behalf of itself and the other
Second Priority Secured Parties, that none of them will seek relief from the automatic stay or from any other stay in any Insolvency Proceeding or take any action in derogation thereof, in each case in respect of any Common Collateral, without
the prior written consent of the First Priority Creditor. 
 5.4. Adequate Protection. The Second Priority Representative,
on behalf of itself and the other Second Priority Secured Parties, agrees that none of them shall object, contest, or support any other Person objecting to or contesting, (a) any request by the First Priority Creditor or the other
First Priority Secured Parties for adequate protection of its interest in the Common Collateral or any adequate protection provided to the First Priority Creditor or the other First Priority Secured Parties, (b) any objection by
the First Priority Creditor or any other First Priority Secured Parties to any motion, relief, action or proceeding based on a claim of a lack of adequate protection in the Common Collateral or (c) the payment of interest, fees,
expenses or other amounts to the First Priority Creditor or any other First Priority Secured Party under Section 506(b) or 506(c) of the Bankruptcy Code or otherwise. The Second Priority Representative, on behalf of itself and
the other Second Priority Secured Parties, further agrees that, prior to the First Priority Obligations Payment Date, none of them shall assert or enforce any claim under Section 506(b) or 506(c) of the Bankruptcy Code or otherwise
that is senior to or on a parity with the First Priority Liens for costs or expenses of preserving or 

  
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disposing of any Common Collateral. Notwithstanding anything to the contrary set forth in this Section and in Section 5.2(b), but subject to all other provisions of this
Agreement (including, without limitation, Section 5.2(a) and Section 5.3), in any Insolvency Proceeding, (i) if the First Priority Secured Parties (or any subset thereof) are granted adequate protection consisting
of additional collateral that constitutes Common Collateral (with replacement liens on such additional collateral) and superpriority claims in connection with any DIP Financing or use of cash collateral with respect to the Common Collateral, and the
First Priority Secured Parties do not object to the adequate protection being provided to them, then in connection with any such DIP Financing or use of cash collateral the Second Priority Representative, on behalf of itself and any of the
Second Priority Secured Parties, may, as adequate protection of their interests in the Common Collateral, seek or accept adequate protection consisting solely of (x) a replacement Lien on the same additional collateral, subordinated to the
Liens securing the First Priority Obligations and such DIP Financing on the same basis as the other Second Priority Liens on the Common Collateral are so subordinated to the First Priority Obligations under this Agreement,
(y) superpriority claims junior in all respects to the superpriority claims granted to the First Priority Secured Parties and (z) subject to the right of the First Priority Secured Parties to object thereto, the payment of post-petition interest at the pre- default rate (provided, in the case of this clause (z), that the First Priority Secured Parties have been granted adequate
protection in the form of post-petition interest at a rate no lower than the pre-default rate), provided, however, that the Second Priority
Representative shall have irrevocably agreed, pursuant to Section 1129(a)(9) of the Bankruptcy Code, on behalf of itself and the Second Priority Secured Parties, in any stipulation and/or order granting such adequate protection, that such
junior superpriority claims may be paid under any plan of reorganization in any combination of cash, debt, equity or other property having a value on the effective date of such plan equal to the allowed amount of such claims and (ii) in the
event the Second Priority Representative, on behalf of itself and the Second Priority Secured Parties, seeks or accepts adequate protection in accordance with clause (i) above and such adequate protection is granted in the form of
additional collateral, then the Second Priority Representative, on behalf of itself or any of the Second Priority Secured Parties, agrees that the First Priority Creditor shall also be granted a senior Lien on such additional
collateral as security for the First Priority Obligations and any such DIP Financing and that any Lien on such additional collateral securing the Second Priority Obligations shall be subordinated to the Liens on such collateral securing
the First Priority Obligations and any such DIP Financing (and all Obligations relating thereto) and any other Liens granted to the First Priority Secured Parties as adequate protection, with such subordination to be on the same terms that
the other Liens securing the Second Priority Obligations are subordinated to such First Priority Obligations under this Agreement. The Second Priority Representative, on behalf of itself and the other Second Priority Secured
Parties, agrees that except as expressly set forth in this Section none of them shall seek or accept adequate protection with respect to their interests in the Common Collateral without the prior written consent of the
First Priority Creditor. 
 5.5. Avoidance Issues. If any First Priority Secured Party is required in any Insolvency
Proceeding or otherwise to disgorge, turn over or otherwise pay to the estate of the Company, because such amount was avoided or ordered to be paid or disgorged for any reason, including without limitation because it was found to be a fraudulent or
preferential transfer, any amount (a “Recovery”), whether received as proceeds of security, enforcement of any right of set-off or otherwise, then the First Priority Obligations shall be
reinstated to the extent of such 

  
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Recovery and deemed to be outstanding as if such payment had not occurred and the First Priority Obligations Payment Date shall be deemed not to have occurred. If this Agreement shall have
been terminated prior to such Recovery, this Agreement shall be reinstated in full force and effect, and such prior termination shall not diminish, release, discharge, impair or otherwise affect the obligations of the parties hereto. The
Second Priority Secured Parties agree that none of them shall be entitled to benefit from any avoidance action affecting or otherwise relating to any distribution or allocation made in accordance with this Agreement, whether by preference or
otherwise, it being understood and agreed that the benefit of such avoidance action otherwise allocable to them shall instead be allocated and turned over for application in accordance with the priorities set forth in this Agreement. 

5.6. Asset Dispositions in an Insolvency Proceeding. In an Insolvency Proceeding or otherwise, neither the Second Priority
Representative nor any other Second Priority Secured Party shall oppose any sale or disposition of any assets of the Company that is supported by the First Priority Secured Parties, and the Second Priority Representative and each
other Second Priority Secured Party will be deemed to have consented under Section 363 of the Bankruptcy Code (or otherwise) to any sale supported by the First Priority Secured Parties and to have released their Liens on such assets.

 5.7. Separate Grants of Security and Separate Classification. Each Secured Party acknowledges and agrees that (a) the grants
of Liens pursuant to the First Priority Security Documents and the Second Priority Security Documents constitute two separate and distinct grants of Liens and (b) because of, among other things, their differing rights in the Common
Collateral, the First Priority Obligations and the Second Priority Obligations are fundamentally different from each other and must be separately classified in any plan of reorganization proposed or adopted in an Insolvency Proceeding. To
further effectuate the intent of the parties as provided in the immediately preceding sentence, if it is held that the claims of the First Priority Secured Parties and Second Priority Secured Parties in respect of the Common Collateral
constitute only one secured claim (rather than separate classes of senior and junior secured claims), then the Second Priority Secured Parties hereby acknowledge and agree that all distributions shall be made as if there were separate classes
of senior and junior secured claims against the Company in respect of the Common Collateral, with the effect being that, to the extent that the aggregate value of the Common Collateral is sufficient (for this purpose ignoring all claims held by the
Second Priority Secured Parties), the First Priority Secured Parties shall be entitled to receive, in addition to amounts distributed to them in respect of principal, pre-petition interest and other
claims, all amounts owing in respect of Post-Petition Interest before any distribution is made in respect of the claims held by the Second Secured Priority Secured Parties. The Second Priority
Secured Parties hereby acknowledge and agree to turn over to the First Priority Secured Parties amounts otherwise received or receivable by them to the extent necessary to effectuate the intent of the preceding sentence, even if such turnover
has the effect of reducing the claim or recovery of the Second Priority Secured Parties. 
 5.8. No Waivers of Rights of
First Priority Secured Parties. Nothing contained herein shall prohibit or in any way limit the First Priority Creditor or any other First Priority Secured Party from objecting in any Insolvency Proceeding or otherwise to any
action taken by any Second Priority Secured Party, including the seeking by any Second Priority Secured Party of adequate protection (except as provided in Section 5.4). 

  
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 5.9. Plans of Reorganization. No Second Priority Secured Party shall propose, support
or vote in favor of any plan of reorganization (and each shall be deemed to have voted to reject any plan of reorganization) unless such plan (a) pays off, in cash in full, all First Priority Obligations or (b) is accepted by the
class of holders of First Priority Obligations voting thereon and is supported by the First Priority Creditor. 
 5.10. Other
Matters. To the extent that the Second Priority Representative or any Second Priority Secured Party has or acquires rights under Section 363 or Section 364 of the Bankruptcy Code (or otherwise) with respect to any of the
Common Collateral, the Second Priority Representative agrees, on behalf of itself and the other Second Priority Secured Parties not to assert any of such rights without the prior written consent of the First Priority Creditor;
provided that if requested by the First Priority Creditor, the Second Priority Representative shall, at the sole cost and expenses of the Company, timely exercise such rights in the manner requested by the First Priority
Creditor, including any rights to payments in respect of such rights. 
 5.11. Effectiveness in Insolvency Proceedings. This
Agreement, which the parties hereto expressly acknowledge is a “subordination agreement” under section 510(a) of the Bankruptcy Code, shall be effective before, during and after the commencement of an Insolvency Proceeding. 

SECTION 6. Security Documents. 

(a) The Company and the Second Priority Representative, on behalf of itself and the Second Priority Secured Parties, agrees that it
shall not at any time execute or deliver any amendment or other modification to any of the Second Priority Documents in violation of this Agreement. 

(b) The Company and the First Priority Creditor, on behalf of itself and the First Priority Secured Parties, agrees that it shall
not at any time execute or deliver any amendment or other modification to any of the First Priority Documents in violation of this Agreement. 

(c) In the event the First Priority Creditor enters into any amendment, waiver or consent in respect of any of the First Priority
Security Documents for the purpose of adding to, or deleting from, or waiving or consenting to any departures from any provisions of, any First Priority Security Document or changing in any manner the rights of any parties thereunder (other
than with respect to amendments, modifications or waivers that secure additional extensions of credit and add additional secured creditors or add additional guarantees or collateral), then such amendment, waiver or consent shall apply to any
comparable provision of the Comparable Second Priority Security Document (with all such amendments, waivers and modifications subject to the terms hereof) and the Company and the Second Priority Secured Parties (and the required
Second Priority Secured Parties shall instruct the Second Priority Representative in writing to execute the same) will work in good faith to promptly negotiate and execute any necessary amendments to such Comparable Second Priority
Security Documents to give effect to this Section 6(c); provided, that (i) no such amendment, waiver or consent shall have the effect of removing assets subject to the Lien of any Second Priority Security Document,


  
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except to the extent that a release of such Lien is permitted by Section 4.2, (ii) any such amendment, waiver or consent that materially and adversely affects the rights of the
Second Priority Secured Parties (other than the Second Priority Representative) and does not affect the First Priority Secured Parties in a like or similar manner shall not apply to the Second Priority Security Documents without
the consent of the Second Priority Representative (to be given or withheld in accordance with the Second Priority Agreement), and (iii) notice of such amendment, waiver or consent shall be given to the Second Priority
Representative no later than 30 days after its effectiveness; provided that the failure to give such notice shall not affect the effectiveness and validity thereof. The Second Priority Documents may not be amended in a manner that would
increase (i) the principal amount thereunder or (ii) the interest rate thereon, in each case, without the prior written consent of the First Priority Creditor. 

(d) The First Priority Obligations and the Second Priority Obligations may be refinanced or replaced, in whole or in part, in each
case, without notice to, or the consent (except to the extent a consent is otherwise required to permit the refinancing transaction under any First Priority Agreement or any Second Priority Agreement) of any First Priority Secured
Party or any Second Priority Secured Party, all without affecting the Lien priorities provided for herein or the other provisions hereof; provided, however, that the holders of any such refinancing or replacement Indebtedness (or
an authorized agent or trustee on their behalf) bind themselves in writing to the terms of this Agreement pursuant to such documents or agreements (including amendments or supplements to this Agreement) as the First Priority Creditor or the
Second Priority Representative, as the case may be, shall reasonably request and in form and substance reasonably acceptable to the First Priority Creditor or the Second Priority Representative, as the case may be; provided
that such documents or agreements shall comply with Section 6(a) and Section 6(b). 
 (e) If at any time in
connection with or after the discharge of all First Priority Obligations, the Company enters into any replacement First Priority Agreement secured by all or a portion of the First Priority Collateral on a first-priority basis, then such prior discharge of First Priority Obligations shall automatically be deemed not to have occurred for the purposes of this Agreement, and the obligations under such replacement
First Priority Agreement shall automatically be treated as First Priority Obligations for all purposes of this Agreement, including for purposes of the Lien priorities and rights in respect of the First Priority Collateral (or such
portion thereof) set forth therein; provided that, the First Priority Secured Parties, the Second Priority Secured Parties (and the required Second Priority Secured Parties shall instruct the Second Priority Representative
to execute the same) and the Company will work in good faith to promptly negotiate and execute an amendment to this Agreement giving effect to this Section 6(e). 

(f) In connection with any refinancing or replacement contemplated by Section 6(d) or 6(e), this Agreement may be amended
at the request and sole expense of the Company, and without the consent of the First Priority Creditor, the First Priority Secured Parties, or the Second Priority Representative or the Second Priority Secured Parties (a) to
add parties (or any authorized agent or trustee therefor) providing any such refinancing or replacement indebtedness, (b) to establish that Liens on any First Priority Collateral securing such refinancing or replacement indebtedness shall
have the same priority (or junior priority) as the Liens on any First Priority Collateral securing the Indebtedness being refinanced or replaced 

  
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and (c) to establish that Liens on any Second Priority Collateral securing such refinancing or replacement indebtedness shall have the same priority as the Liens on any
Second Priority Collateral securing the indebtedness being refinanced or replaced, all on the terms provided for immediately prior to such refinancing or replacement. 

SECTION 7. Reliance; Waivers; etc. 

7.1. Reliance. The First Priority Documents are deemed to have been executed and delivered, and all extensions of credit thereunder
are deemed to have been made or incurred, in reliance upon this Agreement. The Second Priority Representative, on behalf of itself and the Second Priority Secured Parties, expressly waives all notice of the acceptance of and reliance on
this Agreement by the First Priority Secured Parties. The Second Priority Documents are deemed to have been executed and delivered and all extensions of credit thereunder are deemed to have been made or incurred, in reliance upon this
Agreement. The First Priority Creditor expressly waives all notices of the acceptance of and reliance by the Second Priority Representative and the Second Priority Secured Parties. 

7.2. No Warranties or Liability. The Second Priority Representative and the First Priority Creditor acknowledge and agree
that neither has made any representation or warranty with respect to the execution, validity, legality, completeness, collectability or enforceability of any other First Priority Document or any Second Priority Document. Except as
otherwise provided in this Agreement, the Second Priority Representative and the First Priority Creditor will be entitled to manage and supervise their respective extensions of credit to the Company in accordance with law, the relevant
First Priority Documents and Second Priority Documents and their usual practices, modified from time to time as they deem appropriate. 

7.3. No Waivers. No right or benefit of any party hereunder shall at any time in any way be prejudiced or impaired by any act or
failure to act on the part of such party or any other party hereto or by any noncompliance by the Company with the terms and conditions of any of the First Priority Documents or the Second Priority Documents. 

SECTION 8. Obligations Unconditional. 

8.1. First Priority Obligations Unconditional. All rights and interests of the First Priority Secured Parties hereunder, and
all agreements and obligations of the Second Priority Secured Parties (and, to the extent applicable, the Company) hereunder, shall remain in full force and effect irrespective of: 

(a) any lack of validity or enforceability of any First Priority Document; 

(b) any change in the time, place or manner of payment of, or in any other term of, all or any portion of the
First Priority Obligations, or any amendment, waiver or other modification, whether by course of conduct or otherwise, or any refinancing, replacement, refunding or restatement of any First Priority Document; 

(c) prior to the First Priority Obligations Payment Date, any exchange, release, voiding, avoidance or non-perfection of any security interest in any Common 

  
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Collateral or any other collateral, or any release, amendment, waiver or other modification, whether by course of conduct or otherwise, or any refinancing, replacement, refunding or restatement
of all or any portion of the First Priority Obligations or any guarantee or guaranty thereof; or 
 (d) any other
circumstances that otherwise might constitute a defense available to, or a discharge of, the Company in respect of the First Priority Obligations, or of any Second Priority Secured Party, or the Company, to the extent applicable, in
respect of this Agreement. 
 8.2. Second Priority Obligations Unconditional. All rights and interests of the
Second Priority Secured Parties hereunder, and all agreements and obligations of the First Priority Secured Parties (and, to the extent applicable, the Company) hereunder, shall remain in full force and effect irrespective of: 

(a) any lack of validity or enforceability of any Second Priority Document; 

(b) any change in the time, place or manner of payment of, or in any other term of, all or any portion of the
Second Priority Obligations, or any amendment, waiver or other modification, whether by course of conduct or otherwise, or any refinancing, replacement, refunding or restatement of any Second Priority Document; 

(c) any exchange, release, voiding, avoidance or non-perfection of any security
interest in any Common Collateral or any other collateral, or any release, amendment, waiver or other modification, whether by course of conduct or otherwise, or any refinancing, replacement, refunding or restatement of all or any portion of the
Second Priority Obligations or any guarantee or guaranty thereof; or 
 (d) any other circumstances that otherwise might
constitute a defense available to, or a discharge of, the Company in respect of the Second Priority Obligations or any First Priority Secured Party, or the Company, to the extent applicable, in respect of this Agreement. 

SECTION 9. Miscellaneous. 

9.1. Conflicts. In the event of any conflict between the provisions of this Agreement and the provisions of any First Priority
Document or any Second Priority Document, the provisions of this Agreement shall govern. Notwithstanding the foregoing, the parties hereto acknowledge that the terms of this Agreement are not intended to and shall not, as between the Company
and the Secured Parties, negate, impair, waive or cancel any rights granted to, or carry liability or obligation of, the Company in the First Priority Documents and the Second Priority Documents or impose any additional obligations on the
Company (other than as expressly set forth herein). 
 9.2. Continuing Nature of Provisions. This Agreement shall continue to be
effective, and shall not be revocable by any party hereto, until the First Priority Obligation Payment Date shall have occurred. This is a continuing agreement and the First Priority Secured


  
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Parties and the Second Priority Secured Parties may continue, at any time and without notice to the other parties hereto, to extend credit and other financial accommodations, lend monies and
provide indebtedness to, or for the benefit of, the Company on the faith hereof. 
 9.3. Amendments; Waivers. (a) No amendment
or modification of any of the provisions of this Agreement shall be effective unless the same shall be in writing and signed by the First Priority Creditor (in accordance with the First Priority Agreement) and the Second Priority
Representative (in accordance with the Second Priority Agreement), and, in the case of amendments or modifications of Sections 3.5, 3.6, 5.2, 5.4, 6(c), 6(d), 6(e), 6(f), 9.3,
9.5 or 9.6, the Company, and each waiver, if any, shall be a waiver only with respect to the specific instance involved and shall in no way impair the rights of the parties making such waiver or the obligations of the other parties to
such party in any other respect or at any other time. Anything herein to the contrary notwithstanding, no consent of the Company shall be required for amendments, modifications or waivers of any other provisions of this Agreement other than those
that (i) directly affect any obligation or right of the Company hereunder or under the First Priority Documents or the Second Priority Documents or that would impose any additional obligations on the Company or (ii) change the
rights of the Company to refinance the First Priority Obligations or the Second Priority Obligations. 
 9.4. Information
Concerning Financial Condition of the Company. Neither the Second Priority Representative nor the First Priority Creditor hereby assumes responsibility for keeping each other informed of the financial condition of the Company and all
other circumstances bearing upon the risk of nonpayment of the First Priority Obligations or the Second Priority Obligations. The Second Priority Representative and the First Priority Creditor hereby agree that no party shall
have any duty to advise any other party of information known to it regarding such condition or any such circumstances. In the event the Second Priority Representative or the First Priority Creditor, in its sole discretion, undertakes at
any time or from time to time to provide any information to any other party to this Agreement, it shall be under no obligation (a) to provide or update any such information to such other party or any other party on any subsequent occasion,
(b) to undertake any investigation not a part of its regular business routine, or (c) to disclose any other information. Neither the First Priority Creditor nor the Second Priority Representative shall have any responsibility to
monitor or verify the financial condition of the Company. 
 9.5. Governing Law. This Agreement shall be construed in accordance with
and governed by the law of the State of New York, except as otherwise required by mandatory provisions of law and except to the extent that remedies provided by the laws of any jurisdiction other than the State of New York are governed by the laws
of such jurisdiction. 
 9.6. Submission to Jurisdiction. (f) Each First Priority Secured Party, each Second Priority
Secured Party and the Company hereby irrevocably and unconditionally submits, for itself and its property, to the nonexclusive jurisdiction of the courts of the State of New York and of the United States District Court of the Southern District of
New York, and any appellate court from any thereof, in any action or proceeding arising out of or relating to this Agreement, or for recognition or enforcement of any judgment, and each such party hereby irrevocably and unconditionally agrees that
all claims in respect of any such action or proceeding may be heard and determined in such New York State or, to the extent permitted by law, in such Federal court. 

  
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Each such party agrees that a final judgment in any such action or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other manner
provided by law. Nothing in this Agreement shall affect any right that the any First Priority Secured Party or Second Priority Secured Party may otherwise have to bring any action or proceeding against the Company or its properties in the
courts of any jurisdiction. 
 (a) Each First Priority Secured Party, each Second Priority Secured Party and the
Company hereby irrevocably and unconditionally waives, to the fullest extent it may legally and effectively do so (i) any objection it may now or hereafter have to the laying of venue of any suit, action or proceeding arising out of or relating
to this Agreement in any court referred to in paragraph (a) of this Section and (ii) the defense of an inconvenient forum to the maintenance of such action or proceeding. 

(b) Each party to this Agreement irrevocably consents to service of process in the manner provided for notices in
Section 9.7. Nothing in this Agreement will affect the right of any party to this Agreement to serve process in any other manner permitted by law. 

9.7. Notices. Unless otherwise specifically provided herein, any notice or other communication herein required or permitted to be given
shall be in writing and shall be delivered by hand or overnight courier service, mailed by certified or registered mail or sent by facsimile. All such notices and other communications (i) sent by hand or overnight courier service, or mailed by
certified or registered mail, shall be deemed to have been given when received or (ii) sent by facsimile shall be deemed to have been given when sent, provided that if not given during normal business hours for the recipient, shall be
deemed to have been given at the opening of business on the next business day for the recipient. For the purposes hereof, the addresses of the parties hereto (until notice of a change thereof is delivered as provided in this Section) shall be
as set forth below each party’s name on the signature pages hereof, or, as to each party, at such other address as may be designated by such party in a written notice to all of the other parties. 

9.8. Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of each of the parties hereto and each of
the First Priority Secured Parties and Second Priority Secured Parties and their respective successors and permitted assigns, and nothing herein is intended, or shall be construed to give, any other Person any right, remedy or claim under,
to or in respect of this Agreement or any Common Collateral. 
 9.9. Headings. Section headings used herein are for convenience
of reference only, are not part of this Agreement and shall not affect the construction of, or be taken into consideration in interpreting, this Agreement. 

9.10. Severability. Any provision of this Agreement held to be invalid, illegal or unenforceable in any jurisdiction shall, as to such
jurisdiction, be ineffective to the extent of such invalidity, illegality or unenforceability without affecting the validity, legality and enforceability of the remaining provisions hereof; and the invalidity of a particular provision in a
particular jurisdiction shall not invalidate such provision in any other jurisdiction. 

  
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 9.11. Counterparts; Integration; Effectiveness. This Agreement may be executed in
counterparts (and by different parties hereto on different counterparts), each of which shall constitute an original, but all of which when taken together shall constitute a single contract. Delivery of an executed counterpart of a signature page of
this Agreement by email or telecopy shall be effective as delivery of a manually executed counterpart of this Agreement. This Agreement shall become effective when it shall have been executed by each party hereto. 

9.12. WAIVER OF JURY TRIAL. EACH PARTY HERETO HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES TRIAL BY JURY IN ANY LEGAL ACTION
OR PROCEEDING RELATING TO THIS AGREEMENT AND FOR ANY COUNTERCLAIM THEREIN. 
 9.13. Termination; Sun Default.
Notwithstanding anything to the contrary contained in this Agreement: 
 (a) upon the occurrence of the Closing Date (as
defined in the Merger Agreement, the “Merger Agreement Closing Date”)), to the extent the Second Priority Creditors have not been paid in full, (i) all Liens in favor of any Second Priority Secured Party securing the
Second Priority Obligations shall be deemed to rank senior in all respects to the Liens in favor of the First Priority Secured Parties securing the First Priority Secured Obligations, (ii) the First Priority Creditor shall
promptly deliver to the Second Priority Representative or its designees any and all possessory Common Collateral that it is holding pursuant to the terms of the First Priority Documents, and (iii) in furtherance of the foregoing, the
First Priority Creditor and the Majority Holders (as defined in the Existing Second Priority Agreement) (who shall instruct the Second Priority Representative to execute the same) will work in good faith to promptly negotiate and
execute an amendment to this Agreement providing that Ranbaxy, Inc., as the First Priority Creditor under this Agreement, shall become the second priority creditor and U.S. Bank National Association, as collateral agent, and as the
Second Priority Representative under this Agreement, shall become the first priority creditor, all on terms substantially equivalent to those set forth in this Agreement governing the relative priorities and rights of the
First Priority Creditor and Second Priority Creditors (the “Post Merger Amended Intercreditor Agreement”), upon and after which the Post Merger Amended Intercreditor Agreement shall be deemed the “Intercreditor
Agreement” as defined in the Existing First Priority Agreement; and 
 (b) upon the occurrence, and during the
continuation of, a Sun Default (i) all Liens in favor of any Second Priority Secured Party securing the Second Priority Obligations shall be deemed to rank pari passu in all respects with the Liens in favor of the First Priority
Secured Parties securing the First Priority Secured Obligations and (ii) in furtherance of the foregoing, the First Priority Creditor and the Majority Holders (as defined in the Existing Second Priority Agreement) (who shall
instruct the Second Priority Representative to execute the same) will work in good faith to promptly negotiate and execute an amendment to this Agreement to give effect to such pari passu ranking. 

  
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 9.14. Amendment to Second Priority Documents. Notwithstanding anything contained in
the Second Priority Documents, Company and the Second Priority Representative agree that the First Priority Security Documents shall be deemed a “Permitted Lien” thereunder. 

[Signature Pages Follow] 

  
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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date
first written above. 
  

			
	RANBAXY, INC., as First Priority Creditor for and on behalf of the First Priority Secured Parties
		
	By:	 	  

		 	Name:
		 	Title:


 Address for Notices: 
 Sun
Pharmaceutical Industries Limited 
 Acme Plaza 
 Andheri Kurla
Road, Andheri (East) 
 Mumbai, Maharashtra 
 India, 400059 


	Facsimile:	+91 22 6645 5685 


	Attention:	Mr. Uday Baldota 

 Email: uday.baldota@sunpharma.com 

With copies to: 
 Shearman & Sterling LLP 

599 Lexington Avenue 
 New York, NY 10022 

	Facsimile:	(646) 848-5261 


	Attention:	Patrick Flanagan 

 Email: pat.flanagan@shearman.com 

  
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	U.S. BANK NATIONAL ASSOCIATION, as Second Priority Representative for and on behalf of the Second Priority Secured Parties
		
	By:	 	  

		 	Name: Jean Clarke
		 	Title: Vice President


 Address for Notices: 

U.S. Bank National Association 
 Global Trust Services 

100 Wall Street, Suite 1600 
 New York, New York 10005 

	Facsimile:	212-951-6986 


	Attention:	Jean Clarke, Vice President 

 Email: jean.clarke@usbank.com 

  
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	INSITE VISION INCORPORATED
		
	By:	 	  

		 	Name: Timothy M. Ruane
		 	Title: Chief Executive Officer


 Address for Notices: 

InSite Vision Incorporated 
 965 Atlantic Avenue 

Alameda, California 94501 

	Facsimile:	(510) 747-1382 


	Attention:	Timothy M. Ruane 

 Email: TRuane@insite.com 

  
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