Exhibit 4.8

SERVICES AGREEMENT



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|BETWEEN: |                                                               | 1. Celyad S.A., a company established under the laws of Belgium, with registered office at B-1435 Mont-Saint-Guibert, Rue Edouard Belin 12 (Belgium) and registered with the legal entity
Register of Nivelles under number 0891.118.115,
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|         |                                                               | represented by Christian Homsy, CEO                                                                                                                                                                                                      
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|         |                                                               | hereinafter referred to as the Company;                                                                                                                                                                                                
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|AND:     |                                                               | 2. KNCL SPRL a company established under the laws of Belgium, with registered office at Venelle Grand Bon Dieu du Tour 20, 1300 Wavre,                                                                                                   
|        
|         | represented by Jean-Pierre Latere DwanIsa, managing
director
|         | hereinafter referred to as the Services
Provider;          

The Company and the Services Provider are collectively referred to as the Partiesand
individually as a Party.

WHEREAS:

The Companys business is to develop regenerative therapies for the treatment of unmet medical needs, currently developing product candidates for the
treatment of cardiovascular diseases and cancers.

The Services Provider has a dedicated expertise in the medical devices field and is willing to provide
management services to the Company by leading the Medical Devices franchise of the Company.

The Services Provider was appointed as Vice-President Medical
Devices on January 4 2016 by a decision of the Chief Executive Officer, entrusted with the Companys daily management.

By this agreement (the
Agreement),the Parties wish to determine their rights and the obligations with regards to the performance of the Services, as defined hereinafter under Article 2.1.

IT HAS BEEN AGREED THEREFORE WHAT FOLLOWS:

Article 1 - Definitions

In the Agreement, the
following terms shall have the following meanings (unless the context requires otherwise):

Board:the board of directors of the Company;



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Capacity:as agent, manager, director, employee, owner, partner, shareholder or in any other capacity;

Competing Business:a business which is similar to or in any way competes with the business of the Company;

Confidential Information:information (whether or not recorded in documentary form, or stored on any magnetic or optical disk or memory) relating to
the business, products, affairs and finances of the Company for the time being confidential to the Company and trade secrets including, without limitation, technical data and know-how relating to the business
of the Company or any of its business contacts;

Termination Date:the date of termination of the Agreement howsoever arising.

Article 2  Services to be provided by the Services Provider



|2.1. | The Services Provider will provide services to the Company as defined in Exhibit A (hereinafter collectively referred to as the Services):
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|2.2. | The Services Provider will perform the Services full time as member of the Executive Management Team.
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|2.3. | The Services Provider shall comply with all reasonable standards of safety and comply with the Companys health and safety procedures in force at the premises where the Services are provided.
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|2.4. | The Parties hereby agree that the Services will be rendered and performed by the Services Provider. In case of death of the Services Provider, the Agreement shall automatically terminate pursuant to the provisions of
Article 10.2. hereafter. If the Services Provider is unable to perform the Services described in point 2.1. for more than 3 consecutive months for any reason whatsoever (such as incapacity) other than death (hereinafter the
Default),the Company may also automatically terminate pursuant to the provision of Article 10.2. hereafter.
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|2.5. | The Company shall put at the disposal of the Services Provider, at the registered office of the Company, all financial and technical means and the human resources necessary for the performance of the Services, such as
(this list not being exhaustive) furnished premises, administrative and scientific staff or telecommunication means, within a budget approved beforehand by the Board.
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|2.6. | The Company shall give the Services Provider access to all information needed for the proper performance of the Services. It is however agreed by the Parties that all material, records or information, on whatever media,
which shall be at the disposal of the Services Provider, shall remain the ownership of the Company. On Termination Date, the Services Provider shall comply with the provisions of Article 11 hereafter.
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Article 3  Non-exclusivity

Nothing in the Agreement shall prevent the Services Provider from being involved or having any financial interest in any Capacity in any other business, trade,
profession or occupation during the Agreement provided that such activity:



| | (a) | does not cause a breach of any of the Services Providers obligations under the Agreement;
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| | (b) | is not detrimental to the proper performance of the Agreement; and
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| | (c) | is not related to a Competing Business, it being understood that this prohibition shall also extend to a period of six months after Termination Date if Termination is resulting from Companys own decision or
default.
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Article 4  Fees, bonus, expenses, invoicing and payment terms



|4.1. | In consideration of the provision of the Services, the Company shall pay to the Services Provider twelve instalments of 18.300 exclusive VAT per year (corresponding to an annual fee of 219.600). This
monthly fee is payable by bank transfer to the account designated by the Services Provider (hereinafter the Fee)no later than 20 days after transmission to the Companys accounting department.
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|4.2. | The Company shall reimburse (or procure the reimbursement of) all reasonable expenses, properly and necessarily incurred by the Services Provider in the course of the performance of the Agreement and evidenced by
receipts or settled invoices or evidence otherwise approved by the Company as appropriate.
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|4.3. | The Target Bonus, if any, will be capped at 30% of the annual compensation. It will be considered as due to the Services Provider 30 days following the approval of its amount by the Board but not later than at the end
of the month of February following the concerned civil year, and will be paid to the Services Provider at the latest within 20 days after the month end following the moment the relevant Bonus is considered to be due. If the Agreement is terminated
before the end of the civil year, and conditioned to the performance of the Service Provider, the Target Bonus and the objectives to be achieved will be calculated prorata temporis.
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|4.4. | The Service Provider will also receive 20.000 warrants of the next warrant plan issued by the Company whenever the Board of Directors of the Company decides to issue a such new plan of warrants (expected to be in
November 2015). Warrants are part of the compensation of the Service Provider.
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|4.5. | The fees together with the bonus scheme and KPIs will be reviewed and potentially adjusted upwards annually.
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|4.6. | When both parties will have executed the Service Agreement, the Service Provider will be entitled to a sign-on bonus of twenty five thousand euros (25,000) (the Sign-on
Bonus), to be paid not later than 30 days after the date of the first service performed.
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The Sign-on Bonus will be reimbursed to the Company if the Service Provider resign from his capacity of Vice President Medical Devices within the first year starting on the Effective Date of this Service Agreement. If
the Service Provider resigns from his capacity of Vice President Medical Devices between the first and the second anniversary of this Service Agreement, 50% of the Sign-on Bonus will be reimbursed to the
Company. No reimbursement shall be due if the Service Agreement is terminated by the Company or due to the Companys default.



|4.7 | If the Medical Devices franchise of the Company or part of this division is subject to a liquidity event during the Agreement or at any time after its Termination Date during an additional period of 6 months, the
Service Provider will be entitled to an extraordinary discretionary bonus to be determined by the Board on due time.
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Are
assimilated to a liquidity event: the sale of the branch to another company not part of the Celyad group, the sale of subsidiary in which the branch was contributed, the merger of a subsidiary in which the branch was contributed.

The Parties agree to better define the calculation mode of the extraordinary bonus when all or part of the Medical Devices franchise will be
carved out from the Company.

Article 5  Confidential Information



|5.1. | The Services Provider shall not (except in the proper course of its duties) either during the Agreement or at any time after the Termination Date for a period of 5 years, use or disclose Confidential Information to any
third party and shall use its best endeavours to prevent the publication or disclosure of any Confidential Information. This restriction does not apply to:
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| | (a) | any use or disclosure authorised by the Company or required by law or by court order; or
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| | (b) | any information which is already in, or comes into, the public domain otherwise than through the Services Providers unauthorized disclosure.
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|5.2. | A Party shall not at any time either during the Agreement or at any time after the Termination Date for a period of 5 years, disclose the subject and contents of the Agreement without the prior written consent of the
other Party, unless disclosure is required by law or by court order and in such case the other Party shall be informed in advance of the contents and timing of such disclosure.
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Article 6 - Non-solicitation of customers and employees

The Services Provider agrees that during the Agreement and for a period of twelve months immediately after Termination Date, the Services Provider
will not, directly or indirectly, for itself or on behalf of any other person, partnership, company or corporation:



| | (a) | divert or attempt to divert any customers, suppliers or accounts from the Company to a Competing Business; or
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| | (b) | call upon any customer or customers of the Company for the purpose of soliciting and/or selling to any such customers, any product or service competing with products or services sold or provided by the Company; or
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| | (c) | induce or attempt to induce any employees of the Company to terminate their employment for the purpose of employment with a Competing Business.
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Article 7  Intellectual Property



|7.1. | All intellectual and industrial property (including, without limitation, patentable inventions and copyrights) conceived or generated by the Service Provider in performance of its Services shall be assigned to and will
be fully owned by the Company and may be used by the Company in connection with its activities and for any other purpose, including commercial exploitation in any manner.
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|7.2. | In the event that, according to the applicable law, the Service Provider has made a patentable contribution to any invention made during the performance of his Services, then he shall be named as co-author in any patent application or publication thereon.
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|7.3. | The Service Provider agrees that he will take all necessary steps to ascertain that any copyright or other right to any ideas, information and know-how, drawings, instruction
sheets, slides, charts or any other creative works developed by him in the framework of the performance of the Services and which relate specifically to the Company or its business, be vested in or transferred to the Company or any other person or
company indicated by the Company, at Companys costs.
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Article 8  Assignability

Neither the Agreement, nor any rights or benefits hereunder, may be assigned, transferred or contributed without the written consent of both Parties hereto,
and any such assignment, transfer or contribution without the consent of the other Party shall be null and void.



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Article 9 - Administrative formalities and liability of the Services Provider



|9.1. | The Services Provider will comply at all times with all applicable legal provisions and more in particular with social security and tax obligations. The Services Provider shall be fully liable for its own income tax,
social security contributions and any other levies or charges arising from the performance of the Services and the payment of the Fee and the Bonus.
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|9.2. | The Company shall hold the Service Provider harmless for any wrongful performance of her obligations under the Agreement, except for gross negligence or fraud and shall indemnify him for any damages suffered as a result
of an action brought against the Company and/or himself by a third party resulting from a wrongful performance of his obligations, excluding any liability resulting from the Service Providers own gross negligence or fraud.
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|9.3. | In case any liability would fall under the Services Provider pursuant to the provision of article 9.2., the Company accepts it would be financially capped to maximum 1 year fees.
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Article 10  Duration of the Agreement and termination



|10.1. | The Agreement is deemed to come into force on [DATE OF EXECUTION] and shall be for an unlimited duration, unless terminated at an earlier time in accordance with the provisions of Articles 2.4, 10.2, 10.3 and 10.4.
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|10.2. | The Agreement shall automatically terminate with immediate effect and without payment of any indemnity in accordance with the provisions of Article 2.4.
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|10.3. | Each party may terminate the Agreement in writing. The Agreement shall automatically terminate with immediate effect upon dismissal of the Services Provider as Vice President Medical Device of the Company. The
Termination Date shall be deemed to be the date of the decision of the Board dismissing the Services Provider. If the Agreement is terminated by the Company for another reason than for a breach of contract, the notice period will correspond up to 3
months of services if the Agreement is terminated within the first year. The notice period will increase by 1 month starting the second year (one month per year of services rendered to the Company) until the end of the fourth year after which the
notice period is capped at 6 months.
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If the Agreement is terminated by the Company for a breach of contract, there will no
indemnity due to the Consultant.



|10.4. | The Agreement shall automatically terminate with immediate effect upon resignation of the Services Provider from its position as Vice President Medical Device of the Company, for whatever reason. The Termination Date
shall be deemed to be the date upon which its resignation shall take effect.
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In such case, the notice period, to the extent
the Company wish to have a notice period, will correspond to 3 months of services.



|10.5. | Notwithstanding any termination of the Agreement, the obligations under Article 3 c, Article 5 and Article 6 shall remain in force for the duration provided for in said clauses.
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Article 11  Obligations upon termination

On Termination Date, the Services Provider shall:



| | (a) | immediately deliver to the Company all documents, books, materials, records, correspondence, papers and information (on whatever media and wherever located) relating to the business or affairs of the Company or its
business contacts, any keys, and any other property of the Company, which is in its possession or under its control;
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| | (b) | irretrievably delete any information relating to the business of the Company stored on any magnetic or optical disk or memory and all matter derived from such sources which is in its possession or under its control
outside the premises of the Company; and
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| | (c) | provide a signed statement that it has complied fully with its obligations under this Article 11.
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Article 12 - Notices and computation of delays



|12.1. | All notices or other communications required or permitted under the Agreement shall be in writing and shall be deemed to have been duly given if (i) delivered personally, (ii) addressed by registered letter.
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|12.2. | Any such notice or communication shall be deemed to have been received:
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| | (a) | if delivered personally at the date of delivery as indicated on the receipt of delivery;
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| | (b) | in the case of registered post, 3 calendar days after the date of posting.
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|12.3. | All notice periods and delays described in the Agreement are calculated in calendar months.
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Article 13 - Headers

The descriptive headings of the Agreement are for the sake of convenience only and shall not control or affect the meaning, construction or interpretation of
any provision of the Agreement.

Article 14  Invalidity of a provision

If any provision of the Agreement shall be declared by any court of competent jurisdiction to be illegal, void or unenforceable, all other provisions of the
Agreement shall not be affected and shall remain in full force and effect, and Parties shall negotiate in good faith to replace such illegal, void or unenforceable provision with a provision that corresponds as closely as possible to the intentions
of the Parties as expressed in such illegal, void or unenforceable provision.

Article 15  Entire agreement and previous contracts

Each Party acknowledges and agrees with the other Party that this Agreement together with any documents referred to in it constitutes the entire
agreement and understanding between the Services Provider and the Company and supersedes any previous agreement between them relating to the Agreement (which shall be deemed to have been terminated by mutual consent).

Article 16  Variation

No variation of the
Agreement or of any of the documents referred to in it shall be valid unless it is in writing and signed by or on behalf of each of the Parties.

Article 17  Governing law and jurisdiction



|17.1. | This Agreement shall be exclusively governed by and construed in accordance with the laws of Belgium.
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|17.2. | Any dispute arising out or in connection with the Agreement shall be submitted to the exclusive jurisdiction of the courts of Brussels, Belgium.
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Executed in two originals in Mont-Saint-Guibert, on December 7, 2015.



|                        |  |  |  |                               
|----------------------- |  |  |  | ------------------------------
|The Company:            |  |  |  | The Services Provider:        
|LOGO                    |  |  |  | LOGO                          
|Mr Christian Homsy      |  |  |  | Mr Jean-Pierre Latere DwanIsa
|Chief Executive Officer |  |  |  | Managing Director             



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