EXHIBIT 31.1


                  CERTIFICATION PURSUANT TO SECTION 302 OF THE
                           SARBANES-OXLEY ACT OF 2002

I, Laurence P. Birch, certify that:

1.       I have reviewed this quarterly report on Form 10-Q of NeoPharm, Inc.;

2.       Based on my knowledge, this report does not contain any untrue
         statement of a material fact or omit to state a material fact necessary
         to make the statements made, in light of the circumstances under which
         such statements were made, not misleading with respect to the period
         covered by this report;

3.       Based on my knowledge, the financial statements, and other financial
         information included in this report, fairly present in all material
         respects the financial condition, results of operations and cash flows
         of the registrant as of, and for, the periods presented in this report;

4.       I am responsible for establishing and maintaining disclosure controls
         and procedures (as defined in Exchange Act Rules 13a-15(e) and
         15d-15(e)) and internal control over financial reporting (as defined in
         Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and
         have:
         (a)  Designed such disclosure controls and procedures, or caused such
              disclosure controls and procedures to be designed under my
              supervision, to ensure that material information relating to the
              registrant, including its consolidated subsidiary, is made known
              to me by others within those entities, particularly during the
              period in which this quarterly report is being prepared;
         (b)  Designed such internal control over financial reporting, or caused
              such internal control over financial reporting to be designed
              under my supervision, to provide reasonable assurance regarding
              the reliability of financial reporting and the preparation of
              financial statements for external purposes in accordance with
              generally accepted accounting principles;
         (c)  Evaluated the effectiveness of the registrant's disclosure
              controls and procedures and presented in this report my
              conclusions about the effectiveness of the disclosure controls and
              procedures, as of the end of the period covered by this report
              based on such evaluation; and
         (d)  Disclosed in this report any change in the registrant's internal
              control over financial reporting that occurred during the
              registrant's most recent fiscal quarter (the registrant's fourth
              fiscal quarter in the case of an annual report) that has
              materially affected, or is reasonably likely to materially affect,
              the registrant's internal control over financial reporting; and

5.       I have disclosed, based on my most recent evaluation of internal
         control over financial reporting, to the registrant's auditors and the
         audit committee of registrant's board of directors (or persons
         performing the equivalent function):
         (a)  All significant deficiencies and material weaknesses in the design
              or operation of internal control over financial reporting which
              are reasonably likely to adversely affect the registrant's ability
              to record, process, summarize and report financial information;
              and
         (b)  Any fraud, whether or not material, that involves management or
              other employees who have a significant role in the registrant's
              internal controls over financial reporting.



Dated:  May 15, 2008                     /s/  Laurence P. Birch
                                         ----------------------------------
                                         Laurence P. Birch
                                         President and Chief Executive Officer
                                         (Principal Executive Officer) and
                                         Acting Chief Financial Officer
                                         (Principal Financial Officer)


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