Cyprodinil Summary of Analytical Chemistry and Residue Data DP#: 402158



### Page 1 of 2 **UNITED STA**

**TES ENVIRONMENTA L PROTECTION A** **GENCY WA** **SHINGTON, D.C. 20460 OFFICE OF**  **CHEMICAL SAFETY AND**  **POLLUTION PREVENTION**


### MEMORANDUM
**Date :**  M ay 

## 2 9 , 2012 **SUBJECT: Cyprodinil**  **.** Codex Harmonization I ssues with the IR
- 4 Request for Expansions

of Existing Crop Group/Representative Commodity Uses to Numerous Crop Subgroups **. PC Code:**  288202 **DP Barcode:** 402158 **Decision No.:** 447576 **Registration No s**  **. :**  100
- 828 , 100
- 953, and 100
- 1317 **Petition No.:** 1E7854 **Regulatory Action:** Am ended Section 3 **Risk Assessment Type:** NA **Case No.:** 7025 **T XR No.:**  NA **CAS No.:** 121552
- 61
- 2 **MRID No.:** NA **40 CFR:** 180. 5 32 

### FROM: Thurston G. Morton , Chemist

Risk Assessment Branch 4 Health Effects Division (7509 P ) **THROUGH:** Elissa Reaves, PhD., Branch Chief

Risk Assessment Branch 4 Health Effects Division (7509 P ) **TO:** Laura Nollen/Barbara Madden

Risk Integration, Minor Use & Emergency Response Branch Registration Division (7505 P )Cyprodinil Summary of Analytical Chemistry and Residue Data DP#: 402158



### Page 2 of 2 **Executive Summary** HED has been asked to further explain the Codex h arm on ization issues with regards to cy prodinil for PP#1E78 54 . Following are the crop subgroups which needed further explanation on Codex harmonization. Summary of US and International Tolerances and Maximum Residue Limits Commodity 1 Tolerance (ppm) /Maximum Residue Limit (mg/kg) US Codex Onion, bulb subgroup 3
- 07A 0.60 0.3 onion, bulb Caneberry subgroup 13
- 07A 10 0.5 raspberries, red, black Small fruit vine c limbing subgroup 13
- 07F, except fuzzy kiwifruit 2.0 3 grapes 5 dried grapes (=currants, raisins and sultanas) Vegetable, leafy, except brassica, subgroup 04A 5 0 10 lettuce, head, lettuce, leaf Fruit, pome, group 11
- 10 1.7 0.05 apple 1 pear 

### For all crop groups/subgroups except grape (which is the representative commodity for Small fruit vine climbing subgroup 13
- 07F, except fuzzy kiwifruit ) ; the maximum residue in the magnitude of the residue studies submitted to the US for support in establishment of to lerances was greater than the Codex MRL . For Small fruit vine climbing subgroup 13
- 07F, except fuzzy kiwifruit ; the agency

will harmonize and set a tolerance at 3.0 ppm. Along with the establishment of the tolerance for Small fruit vine climbing subgroup 13
- 07F, except fuzzy kiwifruit ; the tolerance for grape will be revoked. The tolerance for grape, raisin will be increased from 3.0 to 5.0 ppm to harmonize with Codex. The registrant will need to submit a revised Section F stating the following: Small fruit vine climbing subgroup 13
- 07F, except fuzzy kiwifruit .........3.0 ppm Grape, raisin..........................................................................5.0 ppm Inaddition, the acute dietary exposure analy sis was revised to incorporate the proposed increase in tolerances for grape and raisin. The chronic dietary exposure analy sis did not need reanaly zed since average residues were used. A summary of the revised acute dietary exposure is summarized below. **Summary of Acute Dietary Exposure and Risk for Cyprodinil Harm onizing with Codex on Grape**  **and Raisin**  **Population Subgroup aPAD (m**  **g/kg/day) Acute (95th Percentile)**  **Exposure (m g/kg/day)**  **%aPAD** General U.S. Population

2.0 0.097703 4.9 All Infants (< 1 year old) 0.110128 5.5 Children 1
- 2 years old 0.164214 8.2 Children 3
- 5 years old 0.1378 90 6.9 Children 6
- 12 years old 0.099019 5.0 Youth 13
- 19 years old 0.080767 4.0 Adults 20
- 49 years old 0.093475 4.7 Adults 50+ years old 0.086108 4.3 Females 13
- 49 years old 0.099964 5.0