Flutolanil Dietary Exposure and Risk Assessment DP Number: D4 I 6620 

PC Code: 128975 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

MEMORANDUM 

DATE: 12/ 12/13 

WASHINGTON, D.C. 20460 

OFFICE OF 

CtlEMICAL SAFETY AND 

POLLUTION PREVENTION 

SUBJECT: Flutolanil Chronic Aggregate Dietary (Food and Drinking Water) Exposure 

and Risk Assessment for the Section 3 Registration Actions on Brassica Leafy 

Vegetables (Crop Group 5), Turnip Greens, Peanuts, and Rice, and for 

Registration Review. 

PC Code: 128975 

Decision No.: 480092 

Petition No.: NA 

DP Barcode: D416620 

Registration No.: 7 I 7 I I -28 

Regulatory Action: Section 3 Registration and 

Risk Assessment Type: Single Chemical/ Aggregate Registration Review 

TXR No.:NA Case No.: N/A 

MRIDNos. NA 

REVIEWER: 

THROUGH: 

TO: 

CAS No.: 66332-96-5 

40 CFR: § 180.484 

Nancy Dodd, Chemist /~~A/~ Risk Assessment Branch 3 

Health Effects Division (HED; 7509P) 

David Hrdy, Senior Scientist ~Z(('A/sv~&-L--­ Thurston Morton, Chemist "?~':~ ;-~ Dietary Exposure Science Advisory Council (DESAC) 

Health Effects Division (7509P) 

~~is Olinger, Branch Chief /J/j ~ ... Risk Assessment Branch 3 uyL.------' 

Health Effects Division (7509P) 

William Cutchin/Erin Malone, RM#20 

Registration Division (7505P) 

Page I of 10 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 0416620 

PC Code: 128975 

Executive Summary 

Chronic aggregate dietary (food and drinking water) exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity 

Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture's (USDA's) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA. The analysis 

was conducted in support of a human-health risk assessment for the proposed amendments to 

Section 3 uses offlutolanil on Brassica (cole) leafy vegetables (Crop Group 5), turnip greens, 

peanuts, and rice, and for registration review. This memorandum was reviewed by two peer 

reviewers of the DESAC, per DESAC SOP 2012.1. 

Acute Dietary (Food and Drinking Water) Exposure Assessment 

No appropriate endpoint attributable to a single dose was identified. As no acute dietary 

endpoint was identified, an acute exposure analysis was not performed. 

Chronic Dietary (Food and Drinking Water) Exposure Assessment 

Tolerance-level residues combined with 100% crop treated and default processing factors were 

used to determine the chronic dietary exposure and risk estimates. The chronic dietary 

exposure estimates for food and drinking water are below HED's level of concern for the 

general U.S. population ( 11% of the chronic population adjusted dose ( cPAD)). The most 

highly exposed population subgroup was all infants (<1 year old) at 29% of the cPAD. 

Drinking water was incorporated directly into the dietary assessment. 

Cancer Dietary (Food and Drinking Water) Exposure Assessment 

Flutolanil is classified as "not likely to be carcinogenic to humans," so a quantitative cancer 

dietary assessment was not conducted. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% ofthe PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: ''Available Information on 

Assessing Exposure from Pesticides, A User's Guide;' 2 1-JUN-2000, web link: 

Page 2 of 10 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 0416620 

PC Code: 128975 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-

AUG-1999). 

The most recent dietary risk assessment for flutolanil was conducted by Kristin Rury (911 0/ 10, 

DP Number D371494). 

II. Residue Information 

Flutolanil Use: 

Nichino America, Inc. has proposed 1) adding a banded application to the existing broadcast 

use for peanuts on the suspension concentrate (SC) label; 2) adding the Brassica (cole) leafy 

vegetables crop group and turnip greens to the SC label using dry flowable (DF) residue data; 

3) slightly modifying the established SC use rate on rice. 

For the current action, HED has examined data to support the proposed amendments to Section 

3 uses of flutolanil on Brassica (cole) leafy vegetables (Crop Group 5), turnip greens, peanuts, 

and rice, and for registration review. 

Tolerances are currently established (40 CFR §180.484) for residues offlutolanil, including its 

metabolites and degradates. Compliance with the tolerance levels is to be determined by 

measuring only flutolanil and its metabolites converted to 2-(trifluoromethyl)benzoic acid and 

calculated as flutolanil. 

Tolerances are established [40 CFR § 180.484(a)] on cotton, peanut, potato, rice, soybean, 

turnip greens, Brassica leafy vegetables, and livestock commodities at levels ranging from 

0.05 ppm to 25.0 ppm. Inadvertent or indirect tolerances [ 40 CFR§ 180.484(d)] are also 

currently established on wheat commodities at levels ranging from 0.05 ppm to 2.5 ppm. 

Residue Data Used for Chronic Assessments 

The established tolerances in 40 CFR §180.484 or recommended tolerances (D413582, N. 

Dodd, 12112113) were used to conduct the chronic analysis. The subject amendments do not 

affect tolerance levels for livestock commodities included in DEEM. Default processing 

factors were used. 

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 

2009, and 20 1 0. In general, pesticide residues would not be expected to be found in fish 

unless the pesticide bioaccumulates or has an aquatic use. To determine whether or not 

residues are present in fish, HED now routinely checks PDP monitoring data regardless of the 

pesticide's uses and physicochemical properties. In 2008, PDP analyzed 552 samples of 

catfish for flutolanil residues. None of the samples contained detectable residues of flutolanil. 

PDP did not analyze catfish samples for flutolanil in 2009 or 2010. As a result, residues in 

fish were not included in the assessment. 

Page 3 of 10 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 0416620 

PC Code: 128975 

III. Percent Crop Treated Information 

In the chronic analysis, 1 00% crop treated assumptions were used. 

IV. Drinking Water Data 

The drinking water residues used in the dietary assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: "Tier !III 

Estimated Drinking Waters Concentrations ofFlutolanil for the New Uses on Peanuts (Banded 

Applications), Brassica Leafy Vegetables (Crop Group 5) Plus Turnip Greens, Turf and 

Ornamentals for the Product Convoy® Fungicide, and for Increased Annual Rate on Turf for 

the Product ProStar® 70WP Fungicide" (J. Melendez, D414000, 12/ 12/ 13) and were 

incorporated directly into this dietary assessment. Water residues were incorporated in the 

DEEM Food Commodity Intake Database (FCID) into the food categories "water, direct, all 

sources" and "water, indirect, all sources." 

The Tier 1/11 Estimated Drinking Water Concentrations (EDWCs) were calculated using the 

Tier I Rice Model v.l.O (surface waters), the Tier II PRZM/EXAMS models (surface waters), 

the Tier IIII model PRZM-GW (in the Tier I mode), and the Tier I groundwater model SCIGROW for use in the human health risk assessment. 

Results obtained from the models that yielded the highest EDWCs for flutolanil are 

summarized in Table 1. The maximum screening EDWC for chronic exposure is 2530 ppb, 

found in groundwater associated with the use on turf. Residues in surface water are lower. 

The maximum chronic EDWC in surface water is 531 ppb, which is associated with the use 

on nee. 

Because the Metabolism Assessment Review Committee (MARC) determined on 12/1611999 

that only the parent needs be included in drinking water exposure assessments for flutolanil 

(DP Barcode D261391, M. Xue, 1/6/00), no degradates were modeled in this assessment. 

Table 1. Maximum Estimated Drinking Water Concentrations (EDWCs) based on Ground Application 

of Flutolanil on Turf and Ground/Aerial Application on Rice 

Drinking Water Model Scenario!Use1 Acute (ppb) Chronic (ppb) l Cancer/Chronic (ppb) Source 

Surface water Tier l Rice Model Rice 531 <531 

Groundwater PRZM-GW WI Sand Turf 2730 2530 

1 For nee, the apphcatton rate IS 0.980 lb a.1./ A/season; for turf, the apphcat10n rate IS 17 .I lb a.1./ A/year. 

V. DEEM-FCID Program and Consumption Information 

The flutolanil chronic dietary exposure assessment was conducted using the DEEM-FCID, 

Version 3.16, which incorporates 2003-2008 consumption data from USDA's 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; 

Page 4 of 10 
Flutolanil Dietary Exposure and Risk Assessment DP Number: D416620 

PC Code: 128975 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population subgroups. 

Based on analysis of the 2003-2008 WWEIA consumption data, which took into account 

dietary patterns and survey respondents, HED concluded that it is most appropriate to report 

risk for the following population subgroups: the general U.S. population, all infants (<1 year 

old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and 

adults 50-99 years old. 

For a chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by 

the average daily consumption estimate for that food/food form to produce a residue intake 

estimate. The resulting residue intake estimate for each food/food form is summed with the 

residue intake estimates for all other food/food forms on the commodity residue list to arrive at 

the total average estimated exposure. Exposure is expressed in mglkg body weight/day and as 

a percent of the cPAD. This procedure is performed for each population subgroup. 

VI. Toxicological Information 

The doses an.d endpoints for dietary risk assessment were confirmed by the flutolanil risk 

assessment team. A summary of the information is presented in Table 2. Flutolanil has been 

classified as "not likely to be carcinogenic to humans." 

Table 2. Summary of Toxicological Doses a nd Endpoints for F lutolanil for Use in Dietary Exposure Risk 

Assessments 

RID, PAD, 

Exposure/ Point of Uncertainty/ Level of 

FQPA Safety Concern for Study and Toxicological Effects Scenario Departure Factors Risk 

Assessment 

Acute Dietary 

(General 

Population, No risk is expected from this exposure scenario since no hazard was identified from 

including Infants appropriate oral toxicity studies including developmental toxicity studies in rats and 

and Children and rabbits. 

Females 13-49 

years of age) 

Chronic RID = 2-year Chronic study in dogs. 

UFA= lOX 0.5 MRID 40342922 

Chronic Dietary NOAEL= 50 UFH= lOX mg/kglday LOAEL = 250 mglkg/day based on 

(All Populations) mg/kglday FQPA SF= increased incidence of G I toxicity 

IX cPAD = 0.5 (emesis, salivation, soft stool, decrease 

mg/kglday food consumption and decreased body 

weight) 

Pomt of Departure (POD) = A data pomt or an estunated pomt that IS denved from observed dose-response data 

and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant 

human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. 

UF =uncertainty factor. UF A= extrapolation from animal to human (interspecies). UFH = potential variation in 

Page 5 of 10 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 0416620 

PC Code: 128975 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population adj usted dose (a= acute, c = chronic). RID = reference dose. 

VII. Results/Discussion 

Results of Chronic Dietary (food and Drinking Water) Exposure and Risk Analysis 

The results of the chronic dietary exposure and risk analysis are reported in Table 3 below. 

The chronic risk estimates were below the Agency's level of concern (<1 00% cPAD) for the 

general U.S. population (11% ofthe cPAD) and all population subgroups. The most highly 

exposed population subgroup was all infants (<1 year old) at 29% of the cPAD. 

Table 3. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Flutolanil. 

Acute Dietary Chronic Dietary Cancer 

Population Subgroup 

Dietary Dietary Dietary 

Exposure %aPAD Exposure %cPAD Exposure Risk 

(mg/k2/day) (mg/kg/day) (mg/ k2/day) 

General U.S. Population 0 . 055661 I I 

All Infants (<1 year old)* 0.144721 29 

Children 1-2 years old 0 . 084103 17 

Children 3-5 years old 0 . 070104 14 

Children 6-12 years old N/A NIA 0.049893 10 N/A N/A 

Youth 13-19 years old 0.040594 8.1 

Adults 20-49 years old 0.055422 11 

Adults 50-99 years old 0.053959 II 

Females 13-49 years old 0 . 054666 II 

*The subpopulatton wtth the htghest n sk esttmates. 

VII. Characterization of Inputs/Outputs 

The chronic assessment was an unrefined assessment. Tolerance-level residues, 100% crop 

treated, and default processing factors were used. As the exposure estimates to all population 

subgroups were low, it was not necessary to make refinements to the chronic dietary analysis. 

Further refinement to the analysis could be made through the use of percent crop treated, 

anticipated residues, empirical processing factors, and/or monitoring data. 

VIII. Conclusions 

Based on conservative assumptions, the chronic dietary (food and drinking water) risk 

estimates are well below HED's level of concern for the general U.S. population and all 

population subgroups. 

Page 6 of 10 
Flutolanil Dietary Exposure and Risk Assessment 

PC Code: 128975 

IX. List of Attachments 

Attachment 1: Chronic Food and Drinking Water Residue Input File 

Attachment 2: Chronic Results File 

Page 7 of 10 

DP Number: 0416620 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 0 416620 

PC Code: 128975 

Attachment 1: Chronic Food and Drinking Water Residue Input File 

Filename : C :\Documents and Settings\NDODD\My Oocuments\DEEM Version 3.16\Flutolanil\FLUTOLANIL 

chron ic 12 08 13.R08 

Chemical: FLUTOLANIL 

RfD(Chronic): .S mg/kg bw/day NOEL(Chronic): 50 mg/kg bw/day 

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified : 12 - 09-2013/19:57:40 Program ver. 3.16, 03-08-d 

EPA Crop 

Code Grp Commodity Name 

Def Res 

(ppm) 

0103296000 1C 

0103297000 1C 

0103297001 1C 

0103298000 1C 

0103298001 1C 

0103299000 1C 

01 03299001 1C 

0103300000 1C 

0103300001 1C 

OS01061000 SA 

0501061001 SA 

0501062000 SA 

0501064000 SA 

OS01069000 SA 

0501071000 SA 

OS01072000 SA 

OS01083000 SA 

0501196000 SA 

0502063000 SB 

OS02070000 SB 

0502117000 SB 

OS02194000 SB 

OS02229000 SB 

05023 18 000 5B 

0502389000 SB 

0600347000 6 

0600349000 6 

0600349001 6 

06003SOOOO 6 

06003 S0001 6 

0603348000 6C 

0603348001 6C 

1S00323000 1S 

1500323001 1 5 

1S00324000 15 

1S00324001 15 

1S0032SOOO 1S 

1S0032S001 1S 

1500326000 15 

1500326001 15 

1500401000 15 

1S00401001 15 

1S00402000 1S 

1 500402001 1S 

1 500403000 1S 

1500404000 15 

2003128000 20C 

2003128001 20C 

3100044 000 31 

3100044001 31 

3100045000 31 

3100046000 31 

3100046001 31 

3100047000 31 

310004 7001 31 

Potato, chips 

Potato, dry (granules/ flakes) 

Potato, dry (granules/ flakes) - b 

Potato, flour 

Potato, flour-babyfood 

Potato, tuber, w/peel 

Potato, tuber, w/peel - babyfood 

Potato, tuber, w/o peel 

Potato, tuber , w/o peel-babyfood 

Broccoli 

Broccoli-babyfood 

Broccoli, Chinese 

Brussels sprouts 

Cabbage 

Cabbage, Chinese, napa 

Cabbage, Chinese, mustard 

Cauliflower 

Kohlrabi 

Broccoli raab 

Cabbage, Chinese, bok choy 

Collards 

Kale 

Mustard greens 

Rape greens 

Turnip, greens 

Soybean, seed 

Soybean, soy milk 

Soybean, soy milk- babyfood or in 

Soybean, oil 

Soybean, oil-baby f ood 

Soybean, flour 

Soybean, flour- babyfood 

Rice , white 

Rice, white -babyfood 

Rice, brown 

Rice, brown-babyfood 

Rice, flour 

Rice, flour-babyfood 

Rice, bran 

Rice, bran- babyfood 

Wheat, grain 

Wheat, grain- babyfood 

Wheat, flour 

Wheat, flour-babyfood 

Wheat, germ 

Wheat, bran 

Cottonseed, oil 

Cottonseed, oil-babyfood 

Beef, meat 

Beef, meat-babyfood 

Beef, meat, dried 

Beef, meat byproducts 

Beef, meat byproducts- babyfood 

Beef, fat 

Beef, fat-babyfood 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0 .200000 

0.200000 

0.200000 

0 . 200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0 .2 00000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0 . 200000 

0.200000 

0 .2 00000 

0.200000 

0.200000 

7 . 000000 

7 . 000000 

7.000000 

7.000000 

7.000000 

7.000000 

10.000000 

10.000000 

o.osoooo 

o.osoooo 

o.osoooo 

0 .050000 

0 .0 50000 

0.200000 

0 . 200000 

0 . 200000 

0.050000 

o.osoooo 

o.osoooo 

0.050000 

o.osoooo 

0.100000 

0.100000 

Page 8 of 10 

Adj.Factors 

Ill 112 

1.000 

6.500 

6.500 

6.500 

6.500 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1 .000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1. 000 

1.000 

1 .000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 .000 

1. 000 

1.000 

1.000 

1. 000 

1.000 

1.920 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1.000 

Comment 
Flutolanil 

PC Code: 128975 

31 00048000 31 

3100049000 31 

3100049001 31 

3200169000 32 

3200170000 32 

3200171000 32 

3200172000 32 

3200173000 32 

33001 89000 33 

3400290000 3 4 

34 00290001 34 

3400291000 34 

3400292000 34 

3400292001 34 

3400293000 34 

3400293001 34 

3400294000 34 

3400295000 34 

3500339000 35 

3500339001 35 

3500340000 35 

3500341000 35 

3500341001 35 

3500342000 35 

3500343000 35 

3600222000 36 

360022 2001 36 

360022 300 0 36 

3600223001 36 

3600224000 36 

3600224001 36 

3600225001 36 

4000093000 40 

40 00093001 40 

4000094000 40 

4000095000 40 

4000095001 40 

4000096000 40 

4000096001 40 

4000097000 40 

4000097001 40 

5000382000 50 

5000382001 50 

5000383000 50 

5000383001 50 

5000384000 50 

5000384001 50 

5000385000 50 

5000385001 50 

5000386000 50 

5000386001 50 

6000301000 60 

6000302000 60 

6000303000 60 

6000304000 60 

6000305000 60 

7000145000 70 

7000145001 70 

7000146000 70 

700014 6001 70 

7000147000 70 

7000147001 70 

8601 000000 86A 

8602000000 86B 

950026 3000 0 

9500264000 0 

9500265000 0 

Dietary Exposure and Risk Assessment 

Beef, kidney 

Beef , liver 

Beef, liver-babyfood 

Goat, meat 

Goat, meat byproducts 

Goat, fat 

Goat, kidney 

Goat , liver 

Horse, meat 

Pork, meat 

Pork, meat- babyfood 

Pork, skin 

Pork, meat byproducts 

Pork, meat byproducts-babyfood 

Pork, fat 

Pork, fat-babyfood 

Pork, kidney 

Pork, liver 

Sheep, meat 

Sheep, meat-babyfood 

Sheep, meat byproducts 

Sheep, fat 

Sheep, fat -babyfood 

Sheep, kidney 

Sheep, liver 

Milk, fat 

Milk, fat-baby f ood/infant formu 

Milk, nonfat solids 

Mi lk, nonfat solids-baby food/in 

Milk, water 

Milk, water-babyfood/infant form 

Milk, sugar (lactosel -baby food/ 

Chicken, meat 

Chicken, meat-babyf ood 

Chicken, liver 

Chicken, meat byproducts 

Chicken, meat bypr oducts-babyfoo 

Chicken, fat 

Chicken, fat-babyfood 

Chicken, skin 

Chicken, skin-babyfood 

Turkey, meat 

Turkey, meat-babyf ood 

Turkey, liver 

Turkey, live r-babyfood 

Turkey, meat byproducts 

Turkey, meat byproducts-babyfood 

Turkey, fat 

Turkey, fat-babyfood 

Turkey, skin 

Turkey, skin-babyfood 

Poultry, other, meat 

Poultry, other, liver 

Poultry , other, meat byproducts 

Poultry, other, fat 

Poultry, other, skin 

Egg, whole 

Egg , whole-babyfood 

Egg, white 

Egg, white (solids)-babyfood 

Egg, yolk 

Egg, yolk-babyfood 

Water, direct, all sources 

Water, indirect , a ll sources 

Peanut 

Peanut, butter 

Peanut, oil 

1.000000 

2.000000 

2.000000 

0.050000 

0.050000 

0.100000 

1 . 000000 

2 . 000000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.100000 

0.100000 

1.000000 

2.000000 

0.050000 

0.050000 

0.050000 

0.100000 

0.100000 

1. 000000 

2.000000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

0 .050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

2.530000 

2 . 530000 

0 . 500000 

0.500000 

0 .500000 

Page 9 of 10 

1 .000 

1.000 

1.000 

1.000 

1.000 

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1. 000 

1.000 

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1.890 

1.000 

DP Number: 0416620 

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Flutolanil Dietary Exposure and Risk Assessment DP Number: 0416620 

PC Code: 128975 

Attachment 2: Chronic Results File 

U.S. EPA Ver. 3.16, 03-08- d 

OEEM-FCIO Chronic analysis for FLUTOLANIL NHANES 2003-2008 2-da y 

Residue file name: C:\Documents and Settings\NDOOO\My Oocuments\OEEM Version 

3.16\Flutolanil\FLUTOLANIL chronic 120813.R08 

Adjustment factor n2 used . 

Analysis Date 12-09-2013/1 9:59: 34 Residue file dated: 12-09-2013/19:57:40 

Reference dose (Rf O, Chronic ) = .s mg / kg bw/day 

Total exposure by population subgroup 

Total Exposure 

Population 

Subgroup 

Tota l US Population 

Hispanic 

Non-Hisp-White 

Non- Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20- 4 9 

Adults 50-99 

Female 13-49 

mg/kg 

b ody wt/day 

0.055661 

0.054223 

0.056693 

0 . 046289 

0.067942 

0.052902 

0.185730 

0.052138 

0.074014 

0.047490 

0.038475 

0.042683 

0.052023 

0.057421 

0.052774 

0.14472 1 

0.054711 

0.084103 

0.070104 

0.049893 

0.040594 

0.0554 22 

0.053959 

0.0546 66 

Page 10 of 10 

Percent of 

Rfd 

11 .1\; 

1 0.8% 

11. 3% 

9.3% 

13.6\ 

10.6% 

37. 1% 

10.4% 

14.8\ 

9.5% 

7.7% 

8.5% 

10.4% 

11.5% 

10.6% 

28.9\ 

10 .9% 

1 6.8% 

14.0% 

10.0% 

8.1% 

11.1% 

10.8% 

10.9%