EX-4.1



 Exhibit 4.1 

Execution Version 
  

 
  

FIFTH SUPPLEMENTAL INDENTURE 

GILEAD SCIENCES, INC. 

AND 
 WELLS FARGO BANK,
NATIONAL ASSOCIATION, 
 AS TRUSTEE 

Fifth Supplemental Indenture 

Dated as of September 14, 2015 

Supplementing the Indenture 

Dated as of March 30, 2011 

1.850% Senior Notes due 2018 

2,550% Senior Notes due 2020 

3.250% Senior Notes due 2022 

3.650% Senior Notes due 2026 

4.600% Senior Notes due 2035 

4.750% Senior Notes due 2046 
  

 
  







 FIFTH SUPPLEMENTAL INDENTURE, dated as of September 14, 2015 (this “Fifth
Supplemental Indenture”), between Gilead Sciences, Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”), and Wells Fargo Bank, National Association, a national banking
association, as Trustee (herein called the “Trustee”); 
 RECITALS: 

WHEREAS, the Company and the Trustee have heretofore executed and delivered an Indenture, dated as of March 30, 2011 (as
heretofore supplemented, the “Base Indenture” and, together with the Fifth Supplemental Indenture, the “Indenture”), providing for the issuance from time to time of the Company’s debentures, notes or other
evidences of indebtedness (herein and therein called the “Securities”), to be issued in one or more series as provided in the Base Indenture;  

WHEREAS, Section 12.1 of the Base Indenture permits the Company and the Trustee to enter into an indenture supplemental to the Base
Indenture to establish the form and terms of any series of Securities; 
 WHEREAS, Section 2.1 of the Base Indenture permits the form
of Securities of any series to be established in an indenture supplemental to the Base Indenture; 
 WHEREAS, Section 3.1 of the Base
Indenture permits certain terms of any series of Securities to be established pursuant to an indenture supplemental to the Base Indenture; 

WHEREAS, pursuant to Sections 2.1 and 3.1 of the Base Indenture, the Company desires to provide for the establishment of six new series of
Securities under the Base Indenture, the form and substance of such Securities and the terms, provisions and conditions thereof to be set forth as provided in the Base Indenture and this Fifth Supplemental Indenture; and 

WHEREAS, all things necessary to make this Fifth Supplemental Indenture a valid agreement of the Company, in accordance with its terms, have
been done. 
 NOW, THEREFORE, for and in consideration of the foregoing and the purchase of the Securities of six new series
established by this Fifth Supplemental Indenture by the holders thereof (the “Holders”), it is mutually agreed, for the equal and proportionate benefit of all such Holders, as follows:  

ARTICLE 1 

DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 

Section 1.01 Relation to Base Indenture. This Fifth Supplemental Indenture constitutes a part of the Base Indenture
(the provisions of which, as modified by this Fifth Supplemental Indenture, shall apply to each series of Notes (as defined in Section 7.01(a))) in respect of such series of Notes but shall not modify, amend or otherwise affect the Base
Indenture insofar as it relates to any other series of Securities or modify, amend or otherwise affect in any manner the terms and conditions of the Securities of any other series. 

  
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 Section 1.02 Definitions. For all purposes of this Fifth
Supplemental Indenture, the capitalized terms used herein (i) which are defined in this Section 1.02 have the respective meanings assigned hereto in this Section 1.02 and (ii) which are defined in the Base Indenture (and which
are not defined in this Section 1.02) have the respective meanings assigned thereto in the Base Indenture. For all purposes of this Fifth Supplemental Indenture:  

(a) Unless the context otherwise requires, any reference to an Article or Section refers to an Article or Section, as the case may be, of this
Fifth Supplemental Indenture; 
 (b) The words “herein,” “hereof” and “hereunder” and words of similar import
refer to this Fifth Supplemental Indenture as a whole and not to any particular Article, Section or other subdivision; 
 (c) Headings are
for convenience of reference only and do not affect interpretations; and 
 (d) The terms defined in this Section 1.02(d) have the
meanings assigned to them in this Section and include the plural as well as the singular: 
 “Notes” has the meaning set
forth in Section 7.01(a). 
 ARTICLE 2 

GENERAL TERMS AND CONDITIONS OF THE 2018 NOTES  

Section 2.01 Terms of the 2018 Notes. Pursuant to Sections 2.1 and 3.1 of the Base Indenture, there is hereby
established a new series of Securities, the terms of which shall be as follows:  
 (a) Designation. There is hereby
authorized and established a new series of Securities under the Base Indenture, known and designated as the “1.850% Senior Notes due 2018” (the “2018 Notes”) of the Company. This series of 2018 Notes
is unlimited in aggregate principal amount. The initial aggregate principal amount of the 2018 Notes to be issued under this Fifth Supplemental Indenture shall be $1,000,000,000. Any additional amounts of the 2018 Notes to be issued shall be set
forth in a Company Order. 
 (b) Form and Denominations. The 2018 Notes will be issued only in fully registered form, and the
authorized denominations of the 2018 Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2018 Notes will initially be issued in the form of one or more Global Securities substantially in the form of
Exhibit A attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. The 2018 Notes will be denominated in U.S. dollars and payments of principal, premium, if any, and interest will
be made in U.S. dollars. 
 (c) Maturity Date. The Stated Maturity of principal for the 2018 Notes shall be payable in full on
September 4, 2018 (the “2018 Notes Maturity Date”). 

  
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 (d) Interest. Interest payable on any 2018 Notes Interest Payment Date (as defined below),
the 2018 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately preceding 2018 Notes Interest Payment Date
in respect of which interest has been paid or duly provided for (or from and including the original issue date of September 14, 2015 if no interest has been paid or duly provided for with respect to the 2018 Notes) to but excluding such 2018
Notes Interest Payment Date, 2018 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a “2018 Notes Interest Period”). The 2018 Notes will bear interest at the rate of 1.850% per year
from the original issue date thereof to the 2018 Notes Maturity Date. Interest on the 2018 Notes shall be payable semi-annually in arrears on March 4 and September 4 of each year, beginning on March 4, 2016 (each such date, a
“2018 Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2018 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the event any 2018 Notes
Interest Payment Date on or before the 2018 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall accrue as a result of
such postponement. 
 In the event the 2018 Notes Maturity Date or a Redemption Date for any Note falls on a day that is not a Business Day,
then the related payments of principal, premium, if any, and interest may be made on the next succeeding date that is a Business Day (and no additional interest will accumulate on the amount payable for the period from and after the 2018 Notes
Maturity Date for such 2018 Note). Interest due on the 2018 Notes Maturity Date or a Redemption Date (in each case, whether or not a 2018 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2018 Notes is payable. 

(e) Sinking Fund; Holder Repurchase Right. The 2018 Notes shall not be subject to any sinking fund or analogous provision or be
redeemable at the option of the Holders. 
 (f) Forms. The 2018 Notes shall be substantially in the form of Exhibit A
attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 
 (g) Appointment of
Agent. The Trustee will initially be the Registrar and Paying Agent with respect to the 2018 Notes. 
 (h) Defeasance. Until the
applicable 2018 Notes Maturity Date, the 2018 Notes will be subject to Sections 11.2 and 11.3 of the Base Indenture. 
 (i) Further
Issues. The Company may from time to time, without the consent of the Holders of 2018 Notes, issue additional 2018 Notes. Any such additional 2018 Notes will have the same ranking, interest rate, maturity date and other terms as the 2018 Notes.
Any such additional 2018 Notes, together with the 2018 Notes herein provided for, will constitute a single series of Securities under the Indenture. 

  
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 ARTICLE 3 

GENERAL TERMS AND CONDITIONS OF THE 2020 NOTES  

Section 3.01 Terms of the 2020 Notes. Pursuant to Sections 2.1 and 3.1 of the Base Indenture, there is hereby
established a new series of Securities, the terms of which shall be as follows:  
 (a) Designation. There is hereby
authorized and established a new series of Securities under the Base Indenture, known and designated as the “2.550% Senior Notes due 2020” (the “2020 Notes”) of the Company. This series of 2020 Notes is unlimited in
aggregate principal amount. The initial aggregate principal amount of the 2020 Notes to be issued under this Fifth Supplemental Indenture shall be $2,000,000,000. Any additional amounts of the 2020 Notes to be issued shall be set forth in a Company
Order. 
 (b) Form and Denominations. The 2020 Notes will be issued only in fully registered form, and the authorized denominations
of the 2020 Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2020 Notes will initially be issued in the form of one or more Global Securities substantially in the form of Exhibit B
attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. The 2020 Notes will be denominated in U.S. dollars and payments of principal, premium, if any, and interest will be made in U.S.
dollars. 
 (c) Maturity Date. The Stated Maturity of principal for the 2020 Notes shall be payable in full on September 1, 2020
(the “2020 Notes Maturity Date”). 
 (d) Interest. Interest payable on any 2020 Notes Interest Payment Date (as
defined below), the 2020 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately preceding 2020 Notes
Interest Payment Date in respect of which interest has been paid or duly provided for (or from and including the original issue date of September 14, 2015 if no interest has been paid or duly provided for with respect to the 2020 Notes) to but
excluding such 2020 Notes Interest Payment Date, 2020 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a 2020 Notes Interest Period”). The 2020 Notes will bear interest at the rate of 2.550% per year
from the original issue date thereof to the 2020 Notes Maturity Date. Interest on the 2020 Notes shall be payable semi-annually in arrears on March 1 and September 1 of each year, beginning on March 1, 2016 (each such date, a
“2020 Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2020 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the event any 2020
Notes Interest Payment Date on or before the 2020 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall accrue as a result
of such postponement. 
 In the event the 2020 Notes Maturity Date or a Redemption Date for any Note falls on a day that is not a Business
Day, then the related payments of principal, premium, if any, and interest may be made on the next succeeding date that is a Business Day (and no additional 

  
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interest will accumulate on the amount payable for the period from and after the 2020 Notes Maturity Date for such 2020 Note). Interest due on the 2020 Notes Maturity Date or a Redemption Date
(in each case, whether or not a 2020 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2020 Notes is payable. 

(e) Sinking Fund; Holder Repurchase Right. The 2020 Notes shall not be subject to any sinking fund or analogous provision or be
redeemable at the option of the Holders. 
 (f) Forms. The 2020 Notes shall be substantially in the form of Exhibit B
attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 
 (g) Appointment of
Agent. The Trustee will initially be the Registrar and Paying Agent with respect to the 2020 Notes. 
 (h) Defeasance. Until the
applicable 2020 Notes Maturity Date, the 2020 Notes will be subject to Sections 11.2 and 11.3 of the Base Indenture. 
 (i) Further
Issues. The Company may from time to time, without the consent of the Holders of 2020 Notes, issue additional 2020 Notes. Any such additional 2020 Notes will have the same ranking, interest rate, maturity date and other terms as the 2020 Notes.
Any such additional 2020 Notes, together with the 2020 Notes herein provided for, will constitute a single series of Securities under the Indenture. 

ARTICLE 4 
 GENERAL
TERMS AND CONDITIONS OF THE 2022 NOTES 
 Section 4.01 Terms of the 2022 Notes. Pursuant to Sections 2.1
and 3.1 of the Base Indenture, there is hereby established a new series of Securities, the terms of which shall be as follows: 
 (a)
Designation. There is hereby authorized and established a new series of Securities under the Base Indenture, known and designated as the “3.250% Senior Notes due 2022” (the “2022 Notes”) of the Company. This
series of 2022 Notes is unlimited in aggregate principal amount. The initial aggregate principal amount of the 2022 Notes to be issued under this Fifth Supplemental Indenture shall be $1,000,000,000. Any additional amounts of the 2022 Notes to be
issued shall be set forth in a Company Order. 
 (b) Form and Denominations. The 2022 Notes will be issued only in fully registered
form, and the authorized denominations of the 2022 Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2022 Notes will initially be issued in the form of one or more Global Securities substantially in
the form of Exhibit C attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. The 2022 Notes will be denominated in U.S. dollars and payments of principal, premium, if any, and
interest will be made in U.S. dollars. 

  
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 (c) Maturity Date. The Stated Maturity of principal for the 2022 Notes shall be payable in
full on September 1, 2022 (the “2022 Notes Maturity Date”). 
 (d) Interest. Interest payable on any 2022 Notes
Interest Payment Date (as defined below), the 2022 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately
preceding 2022 Notes Interest Payment Date in respect of which interest has been paid or duly provided for (or from and including the original issue date of September 14, 2015 if no interest has been paid or duly provided for with respect to
the 2022 Notes) to but excluding such 2022 Notes Interest Payment Date, 2022 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a “2022 Notes Interest Period”). The 2022 Notes will bear interest at the
rate of 3.250% per year from the original issue date thereof to the 2022 Notes Maturity Date. Interest on the 2022 Notes shall be payable semi-annually in arrears on March 1 and September 1 of each year, beginning on March 1,
2016 (each such date, a “2022 Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2022 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the
event any 2022 Notes Interest Payment Date on or before the 2022 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall
accrue as a result of such postponement. 
 In the event the 2022 Notes Maturity Date or a Redemption Date for any Note falls on a day that
is not a Business Day, then the related payments of principal, premium, if any, and interest may be made on the next succeeding date that is a Business Day (and no additional interest will accumulate on the amount payable for the period from and
after the 2022 Notes Maturity Date for such 2022 Note). Interest due on the 2022 Notes Maturity Date or a Redemption Date (in each case, whether or not a 2022 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2022
Notes is payable. 
 (e) Sinking Fund; Holder Repurchase Right. The 2022 Notes shall not be subject to any sinking fund or analogous
provision or be redeemable at the option of the Holders. 
 (f) Forms. The 2022 Notes shall be substantially in the form of
Exhibit C attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 
 (g)
Appointment of Agent. The Trustee will initially be the Registrar and Paying Agent with respect to the 2022 Notes. 
 (h)
Defeasance. Until the applicable 2022 Notes Maturity Date, the 2022 Notes will be subject to Sections 11.2 and 11.3 of the Base Indenture. 

(i) Further Issues. The Company may from time to time, without the consent of the Holders of 2022 Notes, issue additional 2022 Notes.
Any such additional 2022 Notes will have the same ranking, interest rate, maturity date and other terms as the 2022 Notes. Any such additional 2022 Notes, together with the 2022 Notes herein provided for, will constitute a single series of
Securities under the Indenture. 

  
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 ARTICLE 5 

GENERAL TERMS AND CONDITIONS OF THE 2026 NOTES 

Section 5.01 Terms of the 2026 Notes. Pursuant to Sections 2.1 and 3.1 of the Base Indenture, there is hereby
established a new series of Securities, the terms of which shall be as follows: 
 (a) Designation. There is hereby authorized and
established a new series of Securities under the Base Indenture, known and designated as the “3.650% Senior Notes due 2026” (the “2026 Notes”) of the Company. This series of 2026 Notes is unlimited in aggregate
principal amount. The initial aggregate principal amount of the 2026 Notes to be issued under this Fifth Supplemental Indenture shall be $2,750,000,000. Any additional amounts of the 2026 Notes to be issued shall be set forth in a Company Order.

 (b) Form and Denominations. The 2026 Notes will be issued only in fully registered form, and the authorized denominations of the
2026 Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2026 Notes will initially be issued in the form of one or more Global Securities substantially in the form of Exhibit D attached hereto,
with such modifications thereto as may be approved by the authorized officer executing the same. The 2026 Notes will be denominated in U.S. dollars and payments of principal, premium, if any, and interest will be made in U.S. dollars. 

(c) Maturity Date. The Stated Maturity of principal for the 2026 Notes shall be payable in full on March 1, 2026 (the
“2026 Notes Maturity Date”). 
 (d) Interest. Interest payable on any 2026 Notes Interest Payment Date (as defined
below), the 2026 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately preceding 2026 Notes Interest
Payment Date in respect of which interest has been paid or duly provided for (or from and including the original issue date of September 14, 2015 if no interest has been paid or duly provided for with respect to the 2026 Notes) to but excluding
such 2026 Notes Interest Payment Date, 2026 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a “2026 Notes Interest Period”). The 2026 Notes will bear interest at the rate of 3.650% per year
from the original issue date thereof to the 2026 Notes Maturity Date. Interest on the 2026 Notes shall be payable semi-annually in arrears on March 1 and September 1 of each year, beginning on March 1, 2016 (each such date, a
“2026 Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2026 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the event any 2026 Notes
Interest Payment Date on or before the 2026 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall accrue as a result of
such postponement. 
 In the event the 2026 Notes Maturity Date or a Redemption Date for any Note falls on a day that is not a Business Day,
then the related payments of principal, premium, if any, and interest may be made on the next succeeding date that is a Business Day (and no additional 

  
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interest will accumulate on the amount payable for the period from and after the 2026 Notes Maturity Date for such 2026 Note). Interest due on the 2026 Notes Maturity Date or a Redemption Date
(in each case, whether or not a 2026 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2026 Notes is payable. 

(e) Sinking Fund; Holder Repurchase Right. The 2026 Notes shall not be subject to any sinking fund or analogous provision or be
redeemable at the option of the Holders. 
 (f) Forms. The 2026 Notes shall be substantially in the form of Exhibit D attached
hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 
 (g) Appointment of Agent.
The Trustee will initially be the Registrar and Paying Agent with respect to the 2026 Notes. 
 (h) Defeasance. Until the applicable
2026 Notes Maturity Date, the 2026 Notes will be subject to Sections 11.2 and 11.3 of the Base Indenture. 
 (i) Further Issues. The
Company may from time to time, without the consent of the Holders of 2026 Notes, issue additional 2026 Notes. Any such additional 2026 Notes will have the same ranking, interest rate, maturity date and other terms as the 2026 Notes. Any such
additional 2026 Notes, together with the 2026 Notes herein provided for, will constitute a single series of Securities under the Indenture. 

ARTICLE 6 
 GENERAL
TERMS AND CONDITIONS OF THE 2035 NOTES 
 Section 6.01 Terms of the 2035 Notes. Pursuant to Sections 2.1 and 3.1
of the Base Indenture, there is hereby established a new series of Securities, the terms of which shall be as follows: 
 (a)
Designation. There is hereby authorized and established a new series of Securities under the Base Indenture, known and designated as the “4.600% Senior Notes due 2035” (the “2035 Notes”) of the Company. This
series of 2035 Notes is unlimited in aggregate principal amount. The initial aggregate principal amount of the 2035 Notes to be issued under this Fifth Supplemental Indenture shall be $1,000,000,000. Any additional amounts of the 2035 Notes to be
issued shall be set forth in a Company Order. 
 (b) Form and Denominations. The 2035 Notes will be issued only in fully registered
form, and the authorized denominations of the 2035 Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2035 Notes will initially be issued in the form of one or more Global Securities substantially in
the form of Exhibit E attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. The 2035 Notes will be denominated in U.S. dollars and payments of principal, premium, if any, and
interest will be made in U.S. dollars. 

  
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 (c) Maturity Date. The Stated Maturity of principal for the 2035 Notes shall be payable in
full on September 1, 2035 (the “2035 Notes Maturity Date”). 
 (d) Interest. Interest payable on any 2035 Notes
Interest Payment Date (as defined below), the 2035 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately
preceding 2035 Notes Interest Payment Date in respect of which interest has been paid or duly provided for (or from and including the original issue date of September 14, 2015 if no interest has been paid or duly provided for with respect to
the 2035 Notes) to but excluding such 2035 Notes Interest Payment Date, 2035 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a “2035 Notes Interest Period”). The 2035 Notes will bear interest at the
rate of 4.600% per year from the original issue date thereof to the 2035 Notes Maturity Date. Interest on the 2035 Notes shall be payable semi-annually in arrears on March 1 and September 1 of each year, beginning on March 1,
2016 (each such date, a “2035 Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2035 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the
event any 2035 Notes Interest Payment Date on or before the 2035 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall
accrue as a result of such postponement. 
 In the event the 2035 Notes Maturity Date or a Redemption Date for any Note falls on a day that
is not a Business Day, then the related payments of principal, premium, if any, and interest may be made on the next succeeding date that is a Business Day (and no additional interest will accumulate on the amount payable for the period from and
after the 2035 Notes Maturity Date for such 2035 Note). Interest due on the 2035 Notes Maturity Date or a Redemption Date (in each case, whether or not a 2035 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2035
Notes is payable. 
 (e) Sinking Fund; Holder Repurchase Right. The 2035 Notes shall not be subject to any sinking fund or analogous
provision or be redeemable at the option of the Holders. 
 (f) Forms. The 2035 Notes shall be substantially in the form of
Exhibit E attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 
 (g)
Appointment of Agent. The Trustee will initially be the Registrar and Paying Agent with respect to the 2035 Notes. 
 (h)
Defeasance. Until the applicable 2035 Notes Maturity Date, the 2035 Notes will be subject to Sections 11.2 and 11.3 of the Base Indenture. 

(i) Further Issues. The Company may from time to time, without the consent of the Holders of 2035 Notes, issue additional 2035 Notes.
Any such additional 2035 Notes will have the same ranking, interest rate, maturity date and other terms as the 2035 Notes. Any such additional 2035 Notes, together with the 2035 Notes herein provided for, will constitute a single series of
Securities under the Indenture. 

  
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 ARTICLE 7 

GENERAL TERMS AND CONDITIONS OF THE 2046 NOTES  

Section 7.01 Terms of the 2046 Notes. Pursuant to Sections 2.1 and 3.1 of the Base Indenture, there is hereby
established a new series of Securities, the terms of which shall be as follows:  
 (a) Designation. There is hereby
authorized and established a new series of Securities under the Base Indenture, known and designated as the “4.750% Senior Notes due 2046” (the “2046 Notes” and, together with the 2018 Notes, the 2020 Notes, the
2022 Notes, the 2026 Notes and the 2035 Notes, the “Notes”) of the Company. This series of 2046 Notes is unlimited in aggregate principal amount. The initial aggregate principal amount of the 2046 Notes to be issued under this Fifth
Supplemental Indenture shall be $2,250,000,000. Any additional amounts of the 2046 Notes to be issued shall be set forth in a Company Order. 

(b) Form and Denominations. The 2046 Notes will be issued only in fully registered form, and the authorized denominations of the 2046
Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2046 Notes will initially be issued in the form of one or more Global Securities substantially in the form of Exhibit F attached hereto,
with such modifications thereto as may be approved by the authorized officer executing the same. The 2046 Notes will be denominated in U.S. dollars and payments of principal, premium, if any, and interest will be made in U.S. dollars. 

(c) Maturity Date. The Stated Maturity of principal for the 2046 Notes shall be payable in full on March 1, 2046 (the
“2046 Notes Maturity Date”). 
 (d) Interest. Interest payable on any 2046 Notes Interest Payment Date (as defined
below), the 2046 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately preceding 2046 Notes Interest
Payment Date in respect of which interest has been paid or duly provided for (or from and including the original issue date of September 14, 2015 if no interest has been paid or duly provided for with respect to the 2046 Notes) to but excluding
such 2046 Notes Interest Payment Date, 2046 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a “2046 Notes Interest Period”). The 2046 Notes will bear interest at the rate of 4.750% per year
from the original issue date thereof to the 2046 Notes Maturity Date. Interest on the 2046 Notes shall be payable semi-annually in arrears on March 1 and September 1 of each year, beginning on March 1, 2016 (each such date, a
“2046 Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2046 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the event any 2046 Notes
Interest Payment Date on or before the 2046 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall accrue as a result of
such postponement. 
 In the event the 2046 Notes Maturity Date or a Redemption Date for any Note falls on a day that is not a Business Day,
then the related payments of principal, premium, if any, and 

  
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interest may be made on the next succeeding date that is a Business Day (and no additional interest will accumulate on the amount payable for the period from and after the 2046 Notes Maturity
Date for such 2046 Note). Interest due on the 2046 Notes Maturity Date or a Redemption Date (in each case, whether or not a 2046 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2046 Notes is payable. 

(e) Sinking Fund; Holder Repurchase Right. The 2046 Notes shall not be subject to any sinking fund or analogous provision or be
redeemable at the option of the Holders. 
 (f) Forms. The 2046 Notes shall be substantially in the form of Exhibit F
attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 
 (g) Appointment of
Agent. The Trustee will initially be the Registrar and Paying Agent with respect to the 2046 Notes. 
 (h) Defeasance. Until the
applicable 2046 Notes Maturity Date, the 2046 Notes will be subject to Sections 11.2 and 11.3 of the Base Indenture. 
 (i) Further
Issues. The Company may from time to time, without the consent of the Holders of 2046 Notes, issue additional 2046 Notes. Any such additional 2046 Notes will have the same ranking, interest rate, maturity date and other terms as the 2046 Notes.
Any such additional 2046 Notes, together with the 2046 Notes herein provided for, will constitute a single series of Securities under the Indenture. 

ARTICLE 8 
 EVENTS OF
DEFAULT 
 Section 8.01 Events of Default. Pursuant to Section 7.1 of the Base Indenture, the term “Event
of Default” with respect to each series of Notes shall include, in addition to those otherwise set forth in Section 7.1 of the Base Indenture, the following: the occurrence with respect to any Debt of the Company individually or in the
aggregate in excess of $100,000,000 of (a) an event of default that results in such Debt becoming due and payable prior to its scheduled maturity (after giving effect to any applicable grace period) or (b) the failure to make any payment
when due (including any applicable grace period) which results in the acceleration of the maturity of such Debt, in each case without such acceleration having been rescinded, annulled or otherwise cured. 

ARTICLE 9 

REDEMPTION OF THE NOTES 

Section 9.01 Optional Redemption by Company. Each series of Notes may be redeemed at the option of the Company on the terms
and conditions set forth in the form of Note as set forth as Exhibit A, Exhibit B, Exhibit C, Exhibit D, Exhibit E or Exhibit F as applicable. 

  
 11 








 ARTICLE 10 

CHANGE OF CONTROL 

Section 10.01 Offer to Purchase Upon Change of Control Triggering Event. Upon the occurrence of a Change of Control
Triggering Event (as defined in the form of Note set forth as Exhibit A, Exhibit B, Exhibit C, Exhibit D, Exhibit E or Exhibit F, as applicable), except with respect to any series of Notes for which the
Company has exercised its option to redeem the Notes of such series in full pursuant to Section 9.01, the Company shall be required to make an offer to each Holder of the applicable series of Notes to repurchase all or any part (equal to $2,000
or an integral multiple of $1,000 in excess thereof) of that Holder’s applicable series of Notes on the terms and conditions set forth in the form of Note set forth as Exhibit A, Exhibit B, Exhibit C, Exhibit D,
Exhibit E or Exhibit F, as applicable. 
 ARTICLE 11 

MISCELLANEOUS 

Section 11.01 Relationship to Existing Base Indenture. This Fifth Supplemental Indenture is a supplemental
indenture within the meaning of the Base Indenture. The Base Indenture, as supplemented and amended by this Fifth Supplemental Indenture, is in all respects ratified, confirmed and approved and, with respect to each series of Notes, the Base
Indenture, as supplemented and amended by this Fifth Supplemental Indenture, shall be read, taken and construed as one and the same instrument. 

Section 11.02 Modification of the Existing Base Indenture. Except as expressly modified by this Fifth
Supplemental Indenture, the provisions of the Base Indenture shall govern the terms and conditions of each series of Notes.  

Section 11.03 Governing Law. This Fifth Supplemental Indenture shall be governed by and construed in
accordance with the laws of the State of New York. 
 Section 11.04 Counterparts. This Fifth
Supplemental Indenture may be executed in any number of counterparts, each of which when so executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument.  

Section 11.05 Trustee Makes No Representation. The recitals contained herein are made by the Company and not
by the Trustee, and the Trustee assumes no responsibility for the correctness thereof. The Trustee makes no representation as to the validity or sufficiency of this Fifth Supplemental Indenture (except for its execution thereof and its certificates
of authentication of any series of Notes).  
 Section 11.06 Separability. In case any provision in the Base
Indenture, this Fifth Supplemental Indenture or any series of Notes shall for any reason be held to be invalid, illegal or unenforceable, the validity, legality or enforceability of the remaining provisions shall not in any way be affected or
impaired thereby. 
 [Signature page follows] 

  
 12 








 IN WITNESS WHEREOF, the parties hereto have caused this Fifth Supplemental Indenture to be
duly executed and attested all as of the day and year first above written.  
 Date: September 14, 2015 

 

					
	 GILEAD SCIENCES, INC.,
 as
Issuer

		
	By:	 	 /s/ Robin L. Washington

		 	Name:	 	Robin L. Washington
		 	Title:	 	Executive Vice President and Chief Financial Officer
	
	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as Trustee

		
	By:	 	 /s/ Martin Reed

		 	Name:	 	 Martin Reed

		 	Title:	 	 Vice President



 [Fifth Supplemental Indenture] 







 EXHIBIT A 

FORM OF 2018 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.  
 GILEAD SCIENCES, INC. 

 

							
	No.         	 		  	 	CUSIP NO. 375558 BE2	  
		 		  	 	$                     	  

 Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the
State of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered
assigns, the principal sum of                      DOLLARS ($             ), as revised
by the Schedule of Increases or Decreases in Global Security attached hereto, on September 4, 2018 and to pay interest thereon from September 14, 2015 or from the most recent Interest Payment Date to which interest has been paid or duly
provided for, semi-annually on March 4 and September 4, in each year, commencing March 4, 2016, at the rate of 1.850% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the February 15 or August 15
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date.  

  
 A-1 








 
Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this
Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this
series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such
notice as may be required by such exchange, all as more fully provided in said Indenture. 
 Payment of the principal of (and premium, if
any) and interest on this Security will be made at the office or agency of the Trustee maintained for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment
of public and private debts. 
 Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which
further provisions shall for all purposes have the same effect as if set forth at this place. 
 Authentication. Unless the
certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 


  
 A-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	GILEAD SCIENCES, INC.
		
	By:	 	  

		 	 Name:
 Title:



 [Global 2018 Note] 

  
 A-3 








 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

									
	Date of authentication:	 		 		 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as Trustee

					
		 		 		 	By:	 	  

		 		 		 		 	Authorized Signatory


  
 A-4 








 [FORM OF REVERSE OF 2018 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fifth Supplemental Indenture dated as of September 14, 2015 (herein called the “Fifth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,000,000,000. The Company may at any time issue additional securities under the Indenture in
unlimited amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject
to redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 12.5 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
 A-5 








 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 

“Independent Investment Banker” means the Reference Treasury Dealer appointed by the Company. 

“Reference Treasury Dealer” means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC,
their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to be a primary U.S. Government securities dealer in New York City (a “Primary Treasury
Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

In the event of redemption of this Security in part only, a new Security or Securities of this series and of like tenor for the unredeemed
portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 
 Change of Control. If a
Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000
in excess thereof), of each Holder’s Securities pursuant to the offer described below (the “Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment
in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the
rights of Holders of Securities on the relevant record date to receive interest due on the relevant Interest Payment Date. 

Within 30 days following any Change of Control Triggering Event or, at the Company’s option, prior to any Change of Control but
after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the transaction or transactions that constitute or may constitute the Change of Control Triggering
Event and offering to repurchase the Securities on the date specified in the notice, which date will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”),
pursuant to the procedures required herein and described in such notice. The Company must comply with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other
securities  

  
 A-6 








 
laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Securities as a result of a Change of Control Triggering Event. To
the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be required to comply with the applicable securities laws and regulations and will not be deemed to have
breached its obligations under the Change of Control provisions herein by virtue of such conflicts. 
 On the Change of Control Payment
Date, the Company will be required, to the extent lawful, to: 
 (a) accept for payment all Securities or portions of Securities properly
tendered, and not validly withdrawn, pursuant to the Change of Control Offer; 
 (b) deposit with the Paying Agent an amount equal to the
Change of Control Payment in respect of all Securities or portions of Securities properly tendered and not validly withdrawn; and 
 (c)
deliver or cause to be delivered to the Trustee the Securities properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Securities or portions of Securities being purchased by the Company. 

The Paying Agent will be required to mail promptly to each Holder who properly tendered Securities the purchase price for such Securities and
the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any; provided
that each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof. 
 Notwithstanding the
foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise
in compliance with the requirements for such an offer made by the Company and the third party purchases all such Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any
Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 
 For purposes of the
foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 
 “Capital
Stock” means the capital stock of every class whether now or hereafter authorized, regardless of whether such capital stock shall be limited to a fixed sum or percentage with respect to the rights of the holders thereof to participate in
dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of such corporation.  

“Change of Control” means the occurrence of any of the following: 

  
 A-7 








 (a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by
way of merger or consolidation), in one or more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in
Section 13(d)(3) of the Exchange Act), other than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction
(including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the
“beneficial owner” (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is
reclassified, consolidated, exchanged or changed, measured by voting power rather than number of shares; 
 (c) the Company consolidates, or
merges with or into any person, or any person consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or
exchanged for cash, securities or other property, other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of
the Voting Stock of the surviving person or any direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 

(d) the first day on which a majority of the Company’s members of its board of directors are not Continuing Directors; or 

(e) the adoption of a plan relating to the Company’s liquidation or dissolution. 

Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be considered to be a Change of Control if (a) the
Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the holding company are substantially the same as the holders
of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more than 50% of the Voting Stock of such holding company.

 “Change of Control Triggering Event” means the occurrence of both a Change of Control and a Rating Event. 

“Continuing Directors” means, as of any date of determination, any member of the Company’s board of directors who
(a) was a member of such board of directors on September 14, 2015 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the Continuing Directors who were members of such
board of directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a director). 

  
 A-8 








 “Investment Grade” means a rating of Baa3 or better by Moody’s (or
its equivalent under any successor rating categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional
Rating Agency or Rating Agencies selected by the Company.  
 “Moody’s” means Moody’s Investors Service,
Inc., a subsidiary of Moody’s Corporation, and its successors. 
 “Rating Agencies” means (a) each of
Moody’s and S&P; and (b) if any of Moody’s or S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a “nationally recognized
statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a replacement agency for Moody’s or
S&P, or both of them, as the case may be. 
 “Rating Event” means, with respect to the Securities, the rating on
the Securities is lowered below Investment Grade by each of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice
of the occurrence of the Change of Control (which 60-day period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and
its successors.  
 “Voting Stock” means, with respect to any specified person as of any date, the Capital
Stock of such person that is at the time entitled to vote generally in the election of the board of directors of such person. 
 The
Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth
in the Indenture, which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 
 No
reference herein to the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security
at the respective due dates, place and rate, and in the Currency herein prescribed. 
 Default and Remedies. If an Event of Default
with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of the Securities at the time outstanding of each series to be  

  
 A-9 








 
affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time outstanding, on behalf of the
Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security
shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or
waiver is made upon this Security. 
 Denominations; Transfer and Exchange. As provided in the Indenture and subject to certain
limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and
any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or the Holder’s attorney duly
authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees.  

The Securities of this series are issuable only in registered form in denominations of $2,000 and any integral multiple of $1,000 in excess
thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different authorized
denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made to a Holder for any such registration of
transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Persons Deemed Owners. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.  
 Miscellaneous. The Indenture and the Securities, including this Security, shall be
governed by and construed in accordance with the laws of the State of New York. 
 All terms used in this Security and not defined
herein shall have the meanings assigned to them in the Indenture. 
 Pursuant to a recommendation promulgated by the Committee on Uniform
Security Identification Procedures, the Company has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers
as printed on the Securities, and reliance may be placed only on the other identification numbers printed hereon. 

  
 A-10 








 Unless the certificate of authentication hereon has been executed by or on behalf of the Trustee
by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 A-11 








 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 

					
	(Please Print or Typewrite Name and Address, including Zip Code, of Assignee)

  

					
	
	 the within Security of Gilead Sciences, Inc. and
                     hereby does irrevocably constitute and appoint

 

	Attorney to transfer said Security on the books of the within-named Company with full power of substitution in the premises
		
	Dated:	 	  

		
	Signature	 	  

	
	NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security in every particular, without alteration or enlargement or any change whatever.
		
	Signature Guaranteed:	 	  

	
	NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or participant in a “signature guarantee program” (e.g., the Securities Transfer Agents
Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program).


  
 A-12 








 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of

Exchange
	  	 Amount of increase in
Principal Amount of

this Global Security
	  	 Amount of decrease

in Principal Amount
 of this
Global
 Security
	  	 Principal Amount of

this Global Security

following such
 decrease or
increase
	  	 Signature of

authorized signatory
 of
Trustee

		  		  		  		  	


  
 A-13 








 EXHIBIT B 

FORM OF 2020 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.  
 GILEAD SCIENCES, INC. 

 

							
	No.         	 		  	 	CUSIP NO. 375558 BB8	  
		 		  	 	$                     	  

 Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the
State of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered
assigns, the principal sum of                      DOLLARS ($            ), as revised by
the Schedule of Increases or Decreases in Global Security attached hereto, on September 1, 2020 and to pay interest thereon from September 14, 2015 or from the most recent Interest Payment Date to which interest has been paid or duly
provided for, semi-annually on March 1 and September 1 in each year, commencing March 1, 2016, at the rate of 2.550% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the February 15 or August 15 (whether or
not a Business Day), as the case may be, next preceding such Interest Payment Date. 

  
 B-1 








 
Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this
Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this
series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such
notice as may be required by such exchange, all as more fully provided in said Indenture. 
 Payment of the principal of (and premium, if
any) and interest on this Security will be made at the office or agency of the Trustee maintained for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment
of public and private debts. 
 Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which
further provisions shall for all purposes have the same effect as if set forth at this place. 
 Authentication. Unless the
certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 


  
 B-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	GILEAD SCIENCES, INC.
		
	By:	 	  

		 	Name:
		 	Title:


 [Global 2020 Note] 

  
 B-3 








 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

									
	Date of authentication:	 		 		 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION, 
 as
Trustee

					
		 		 		 	By:	 	  

		 		 		 		 	Authorized Signatory


  
 B-4 








 [FORM OF REVERSE OF 2020 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fifth Supplemental Indenture dated as of September 14, 2015 (herein called the “Fifth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $2,000,000,000. The Company may at any time issue additional securities under the Indenture in
unlimited amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject
to redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 15 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
 B-5 








 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 
 “Independent
Investment Banker” means the Reference Treasury Dealer appointed by the Company. 
 “Reference Treasury Dealer”
means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC, their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to
be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

In the event of redemption of this Security in part only, a new Security or Securities of this series and of like tenor for the unredeemed
portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 
 Change of Control. If a
Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000
in excess thereof), of each Holder’s Securities pursuant to the offer described below (the “Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment
in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the
rights of Holders of Securities on the relevant record date to receive interest due on the relevant Interest Payment Date. 

Within 30 days following any Change of Control Triggering Event or, at the Company’s option, prior to any Change of Control but
after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the transaction or transactions that constitute or may constitute the Change of Control Triggering
Event and offering to repurchase the Securities on the date specified in the notice, which date will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”),
pursuant to the procedures required herein and described in such notice. The Company must comply with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other
securities  

  
 B-6 








 
laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Securities as a result of a Change of Control Triggering
Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be required to comply with the applicable securities laws and regulations and will not be deemed
to have breached its obligations under the Change of Control provisions herein by virtue of such conflicts. 
 On the Change of
Control Payment Date, the Company will be required, to the extent lawful, to: 
 (a) accept for payment all Securities or portions of
Securities properly tendered, and not validly withdrawn, pursuant to the Change of Control Offer; 
 (b) deposit with the Paying Agent an
amount equal to the Change of Control Payment in respect of all Securities or portions of Securities properly tendered and not validly withdrawn; and 

(c) deliver or cause to be delivered to the Trustee the Securities properly accepted together with an Officers’ Certificate stating the
aggregate principal amount of Securities or portions of Securities being purchased by the Company. 
 The Paying Agent will be
required to mail promptly to each Holder who properly tendered Securities the purchase price for such Securities and the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new
Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any; provided that each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof.  

Notwithstanding the foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the
occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for such an offer made by the Company and the third party purchases all such
Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 

For purposes of the foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 

“Capital Stock” means the capital stock of every class whether now or hereafter authorized, regardless of whether such
capital stock shall be limited to a fixed sum or percentage with respect to the rights of the holders thereof to participate in dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of
such corporation.  
 “Change of Control” means the occurrence of any of the following: 

  
 B-7 








 (a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by
way of merger or consolidation), in one or more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in
Section 13(d)(3) of the Exchange Act), other than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction
(including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the
“beneficial owner” (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is
reclassified, consolidated, exchanged or changed, measured by voting power rather than number of shares; 
 (c) the Company consolidates, or
merges with or into any person, or any person consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or
exchanged for cash, securities or other property, other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of
the Voting Stock of the surviving person or any direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 

(d) the first day on which a majority of the Company’s members of its board of directors are not Continuing Directors; or 

(e) the adoption of a plan relating to the Company’s liquidation or dissolution. 

Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be considered to be a Change of Control if (a) the
Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the holding company are substantially the same as the holders
of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more than 50% of the Voting Stock of such holding company.

 “Change of Control Triggering Event” means the occurrence of both a Change of Control and a Rating Event. 

“Continuing Directors” means, as of any date of determination, any member of the Company’s board of directors who
(a) was a member of such board of directors on September 14, 2015 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the Continuing Directors who were members of such
board of directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a director). 

  
 B-8 








 “Investment Grade” means a rating of Baa3 or better by Moody’s (or
its equivalent under any successor rating categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional
Rating Agency or Rating Agencies selected by the Company.  
 “Moody’s” means Moody’s Investors
Service, Inc., a subsidiary of Moody’s Corporation, and its successors.  
 “Rating Agencies” means
(a) each of Moody’s and S&P; and (b) if any of Moody’s or S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a
“nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a
replacement agency for Moody’s or S&P, or both of them, as the case may be. 
 “Rating Event” means, with
respect to the Securities, the rating on the Securities is lowered below Investment Grade by each of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of
the 60-day period following public notice of the occurrence of the Change of Control (which 60-day period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating
Agencies). 
 “S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill
Companies, Inc., and its successors.  
 “Voting Stock” means, with respect to any specified person as of any
date, the Capital Stock of such person that is at the time entitled to vote generally in the election of the board of directors of such person. 

The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and
Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture, which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 

No reference herein to the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company,
which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security at the respective due dates, place and rate, and in the Currency herein prescribed. 

Default and Remedies. If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of
the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of the Securities at the time outstanding of each series to be  

  
 B-9 








 
affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time outstanding, on behalf of the
Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security
shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or
waiver is made upon this Security. 
 Denominations; Transfer and Exchange. As provided in the Indenture and subject to certain
limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and
any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or the Holder’s attorney duly
authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees.  

The Securities of this series are issuable only in registered form in denominations of $2,000 and any integral multiple of $1,000 in excess
thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different authorized
denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made to a Holder for any such registration of
transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Persons Deemed Owners. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.  
 Miscellaneous. The Indenture and the Securities, including this Security, shall be
governed by and construed in accordance with the laws of the State of New York. 
 All terms used in this Security and not defined
herein shall have the meanings assigned to them in the Indenture. 
 Pursuant to a recommendation promulgated by the Committee on Uniform
Security Identification Procedures, the Company has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers
as printed on the Securities, and reliance may be placed only on the other identification numbers printed hereon. 

  
 B-10 








 Unless the certificate of authentication hereon has been executed by or on behalf of the Trustee
by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 B-11 








 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 

					
	(Please Print or Typewrite Name and Address, including Zip Code, of Assignee)

  

					
	
	 the within Security of Gilead Sciences, Inc. and
                     hereby does irrevocably constitute and appoint

 

	Attorney to transfer said Security on the books of the within-named Company with full power of substitution in the premises
		
	Dated:	 	  

		
	Signature	 	  

	
	NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security in every particular, without alteration or enlargement or any change whatever.
		
	Signature Guaranteed:	 	  

	
	NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or participant in a “signature guarantee program” (e.g., the Securities Transfer Agents
Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program).


  
 B-12 








 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of

Exchange
	  	 Amount of increase in
Principal Amount of

this Global Security
	  	 Amount of decrease
in Principal Amount

of this Global Security
	  	 Principal Amount of

this Global Security
 following
such
 decrease or increase
	  	 Signature of
authorized signatory

of Trustee

		  		  		  		  	


  
 B-13 








 EXHIBIT C 

FORM OF 2022 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.  
 GILEAD SCIENCES, INC. 

 

							
	No.        	 		  	 	CUSIP NO. 375558 BC6	  

 Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the
State of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered
assigns, the principal sum of                      DOLLARS ($            ), as revised by
the Schedule of Increases or Decreases in Global Security attached hereto, on September 1, 2022 and to pay interest thereon from September 14, 2015 or from the most recent Interest Payment Date to which interest has been paid or duly
provided for, semi-annually on March 1 and September 1 in each year, commencing March 1, 2016, at the rate of 3.250% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the February 15 or August 15 (whether or
not a Business Day), as the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable 

  
 C-1 








 
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a
Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any
other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Trustee maintained
for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Authentication. Unless the certificate of authentication hereon has
been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.  

  
 C-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	GILEAD SCIENCES, INC.
		
	By:	 	  

		 	 Name:
 Title:



 [Global 2022 Note] 

  
 C-3 








 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

									
	Date of authentication:	 		 		 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as
Trustee

					
		 		 		 	By:	 	  

		 		 		 		 	Authorized Signatory


  
 C-4 








 [FORM OF REVERSE OF 2022 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fifth Supplemental Indenture dated as of September 14 2015 (herein called the “Fifth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,000,000,000. The Company may at any time issue additional securities under the Indenture in
unlimited amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject
to redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 20 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
 C-5 








 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 
 “Independent
Investment Banker” means the Reference Treasury Dealer appointed by the Company. 
 “Reference Treasury Dealer”
means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC, their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to
be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

The Securities of this series are also subject to redemption at the Company’s option, at any time on or after July 1, 2022, in whole
or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the records of the Registrar, at a Redemption Price equal to 100% of the principal amount of the
Securities to be redeemed, plus accrued and unpaid interest to the Redemption Date. 
 In the event of redemption of this Security in part
only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 

Change of Control. If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem
the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof), of each Holder’s Securities pursuant to the offer described below (the
“Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued
and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the rights of Holders of Securities on the relevant record date to receive interest due on the
relevant Interest Payment Date. 
 Within 30 days following any Change of Control Triggering Event or, at the Company’s option,
prior to any Change of Control but after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the 

  
 C-6 








 
transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Securities on the date specified in the notice, which date will
be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required herein and described in such notice. The Company must comply with
the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in
connection with the repurchase of the Securities as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be
required to comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control provisions herein by virtue of such conflicts. 

On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

(a) accept for payment all Securities or portions of Securities properly tendered, and not validly withdrawn, pursuant to the Change of
Control Offer; 
 (b) deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities or
portions of Securities properly tendered and not validly withdrawn; and 
 (c) deliver or cause to be delivered to the Trustee the
Securities properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Securities or portions of Securities being purchased by the Company. 

The Paying Agent will be required to mail promptly to each Holder who properly tendered Securities the purchase price for such
Securities and the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any;
provided that each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof.  

Notwithstanding the foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the
occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for such an offer made by the Company and the third party purchases all such
Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 

For purposes of the foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 

“Capital Stock” means the capital stock of every class whether now or hereafter authorized, regardless of whether such
capital stock shall be limited to a fixed sum or percentage  

  
 C-7 








 
with respect to the rights of the holders thereof to participate in dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of such
corporation. 
 “Change of Control” means the occurrence of any of the following: 

(a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or
more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other
than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction (including, without limitation, any merger or
consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the “beneficial owner” (as defined in Rule
13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed,
measured by voting power rather than number of shares; 
 (c) the Company consolidates, or merges with or into any person, or any person
consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property,
other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any
direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 
 (d) the first day on which
a majority of the Company’s members of its board of directors are not Continuing Directors; or 
 (e) the adoption of a plan relating
to the Company’s liquidation or dissolution. 
 Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be
considered to be a Change of Control if (a) the Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the
holding company are substantially the same as the holders of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more
than 50% of the Voting Stock of such holding company. 
 “Change of Control Triggering Event” means the occurrence
of both a Change of Control and a Rating Event. 
 “Continuing Directors” means, as of any date of
determination, any member of the Company’s board of directors who (a) was a member of such board of directors on September  

  
 C-8 








 
14, 2015 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the Continuing Directors who were members of such board of
directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a director). 

“Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected
by the Company.  
 “Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s
Corporation, and its successors.  
 “Rating Agencies” means (a) each of Moody’s and S&P; and
(b) if any of Moody’s or S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating
organization” within the meaning of Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a replacement agency for Moody’s or S&P, or both
of them, as the case may be. 
 “Rating Event” means, with respect to the Securities, the rating on the Securities
is lowered below Investment Grade by each of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the
occurrence of the Change of Control (which 60-day period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and
its successors.  
 “Voting Stock” means, with respect to any specified person as of any date, the Capital
Stock of such person that is at the time entitled to vote generally in the election of the board of directors of such person. 
 The
Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth
in the Indenture, which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 
 No
reference herein to the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security
at the respective due dates, place and rate, and in the Currency herein prescribed. 

  
 C-9 








 Default and Remedies. If an Event of Default with respect to Securities of this series
shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of the Securities at the time outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time
outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by
the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not
notation of such consent or waiver is made upon this Security. 
 Denominations; Transfer and Exchange. As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer at the office or agency of the Company in any
place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or
the Holder’s attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or
transferees.  
 The Securities of this series are issuable only in registered form in denominations of $2,000 and any integral
multiple of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor
of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made to a Holder for
any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Persons Deemed Owners. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.  
 Miscellaneous. The Indenture and the Securities, including this Security, shall be
governed by and construed in accordance with the laws of the State of New York. 

  
 C-10 








 All terms used in this Security and not defined herein shall have the meanings assigned to them
in the Indenture. 
 Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company
has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers as printed on the Securities, and reliance may
be placed only on the other identification numbers printed hereon. 
 Unless the certificate of authentication hereon has been executed by
or on behalf of the Trustee by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 C-11 








 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 

					
	(Please Print or Typewrite Name and Address, including Zip Code, of Assignee)

  

					
	
	 the within Security of Gilead Sciences, Inc. and
                     hereby does irrevocably constitute and appoint

 

	Attorney to transfer said Security on the books of the within-named Company with full power of substitution in the premises
		
	Dated:	 	  

		
	Signature	 	  

	
	NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security in every particular, without alteration or enlargement or any change whatever.
		
	Signature Guaranteed:	 	  

	
	NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or participant in a “signature guarantee program” (e.g., the Securities Transfer Agents
Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program).


  
 C-12 








 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of

Exchange
	  	 Amount of increase in
Principal Amount of

this Global Security
	  	 Amount of decrease
in Principal Amount

of this Global Security
	  	 Principal Amount of this
Global Security

following such
 decrease or
increase
	  	 Signature of
authorized signatory

of Trustee

		  		  		  		  	


  
 C-13 








 EXHIBIT D 

FORM OF 2026 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.  
 GILEAD SCIENCES, INC. 

 

							
	No.        	 		  	 	CUSIP NO.375558 BF9	  
		 		  	 	$                     	  

 Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the
State of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered
assigns, the principal sum of                      DOLLARS ($            ), as revised by
the Schedule of Increases or Decreases in Global Security attached hereto, on March 1, 2026 and to pay interest thereon from September 14, 2015 or from the most recent Interest Payment Date to which interest has been paid or duly provided
for, semi-annually on March 1 and September 1 in each year, commencing March 1, 2016, at the rate of 3.650% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the February 15 or August 15
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable 


  
 D-1 








 
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a
Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any
other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Trustee maintained
for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Authentication. Unless the certificate of authentication hereon has
been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.  

  
 D-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	GILEAD SCIENCES, INC.
		
	By:	 	  

		 	 Name:
 Title:



 [Global 2026 Note] 

  
 D-3 








 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

									
	Date of authentication:	 		 		 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as
Trustee

					
		 		 		 	By:	 	  

		 		 		 		 	Authorized Signatory


  
 D-4 








 [FORM OF REVERSE OF 2026 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fifth Supplemental Indenture dated as of September 14, 2015 (herein called the “Fifth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $2,750,000,000. The Company may at any time issue additional securities under the Indenture in
unlimited amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject
to redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 25 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
 D-5 








 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 

“Independent Investment Banker” means the Reference Treasury Dealer appointed by the Company. 

“Reference Treasury Dealer” means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC,
their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to be a primary U.S. Government securities dealer in New York City (a “Primary Treasury
Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

The Securities of this series are also subject to redemption at the Company’s option, at any time on or after December 1, 2025, in
whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the records of the Registrar, at a Redemption Price equal to 100% of the principal amount
of the Securities to be redeemed, plus accrued and unpaid interest to the Redemption Date. 
 In the event of redemption of this Security in
part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 

Change of Control. If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem
the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof), of each Holder’s Securities pursuant to the offer described below (the
“Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued
and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the rights of Holders of Securities on the relevant record date to receive interest due on the
relevant Interest Payment Date. 
 Within 30 days following any Change of Control Triggering Event or, at the Company’s option,
prior to any Change of Control but after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the 

  
 D-6 








 
transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Securities on the date specified in the notice, which date
will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required herein and described in such notice. The Company must comply
with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in
connection with the repurchase of the Securities as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be
required to comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control provisions herein by virtue of such conflicts.  

On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

(a) accept for payment all Securities or portions of Securities properly tendered, and not validly withdrawn, pursuant to the Change of
Control Offer; 
 (b) deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities or
portions of Securities properly tendered and not validly withdrawn; and 
 (c) deliver or cause to be delivered to the Trustee the
Securities properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Securities or portions of Securities being purchased by the Company. 

The Paying Agent will be required to mail promptly to each Holder who properly tendered Securities the purchase price for such
Securities and the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any;
provided that each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof.  

Notwithstanding the foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the
occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for such an offer made by the Company and the third party purchases all such
Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 

For purposes of the foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 

“Capital Stock” means the capital stock of every class whether now or hereafter authorized, regardless of whether such
capital stock shall be limited to a fixed sum or percentage  

  
 D-7 








 
with respect to the rights of the holders thereof to participate in dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of such
corporation. 
 “Change of Control” means the occurrence of any of the following: 

(a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or
more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other
than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction (including, without limitation, any merger or
consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the “beneficial owner” (as defined in Rule
13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed,
measured by voting power rather than number of shares; 
 (c) the Company consolidates, or merges with or into any person, or any person
consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property,
other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any
direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 
 (d) the first day on which
a majority of the Company’s members of its board of directors are not Continuing Directors; or 
 (e) the adoption of a plan relating
to the Company’s liquidation or dissolution. 
 Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be
considered to be a Change of Control if (a) the Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the
holding company are substantially the same as the holders of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more
than 50% of the Voting Stock of such holding company. 
 “Change of Control Triggering Event” means the occurrence of both
a Change of Control and a Rating Event. 
 “Continuing Directors” means, as of any date of determination, any member
of the Company’s board of directors who (a) was a member of such board of directors on September  

  
 D-8 








 
14, 2015 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the Continuing Directors who were members of such board of
directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a director). 

“Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected
by the Company.  
 “Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s
Corporation, and its successors. 
 “Rating Agencies” means (a) each of Moody’s and S&P; and
(b) if any of Moody’s or S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating
organization” within the meaning of Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a replacement agency for Moody’s or S&P, or both
of them, as the case may be. 
 “Rating Event” means, with respect to the Securities, the rating on the Securities
is lowered below Investment Grade by each of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the
occurrence of the Change of Control (which 60-day period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and
its successors.  
 “Voting Stock” means, with respect to any specified person as of any date, the Capital
Stock of such person that is at the time entitled to vote generally in the election of the board of directors of such person. 
 The
Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth
in the Indenture, which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 
 No
reference herein to the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security
at the respective due dates, place and rate, and in the Currency herein prescribed. 

  
 D-9 








 Default and Remedies. If an Event of Default with respect to Securities of this series
shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of the Securities at the time outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time
outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by
the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not
notation of such consent or waiver is made upon this Security. 
 Denominations; Transfer and Exchange. As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer at the office or agency of the Company in any
place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or
the Holder’s attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or
transferees.  
 The Securities of this series are issuable only in registered form in denominations of $2,000 and any integral
multiple of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor
of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made to a Holder for
any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Persons Deemed Owners. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.  
 Miscellaneous. The Indenture and the Securities, including this Security, shall be
governed by and construed in accordance with the laws of the State of New York. 

  
 D-10 








 All terms used in this Security and not defined herein shall have the meanings assigned to them
in the Indenture. 
 Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company
has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers as printed on the Securities, and reliance may
be placed only on the other identification numbers printed hereon. 
 Unless the certificate of authentication hereon has been executed by
or on behalf of the Trustee by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 D-11 








 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 

					
	(Please Print or Typewrite Name and Address, including Zip Code, of Assignee)

  

					
	
	 the within Security of Gilead Sciences, Inc. and
                     hereby does irrevocably constitute and appoint

 

	Attorney to transfer said Security on the books of the within-named Company with full power of substitution in the premises
		
	Dated:	 	  

		
	Signature	 	  

	
	NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security in every particular, without alteration or enlargement or any change whatever.
		
	Signature Guaranteed:	 	  

	
	NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or participant in a “signature guarantee program” (e.g., the Securities Transfer Agents
Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program).


  
 D-12 








 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of

Exchange
	  	Amount of increase in
Principal Amount of
this Global Security	  	Amount of decrease
in Principal Amount
of this Global
Security	  	Principal Amount of
this Global Security
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee
		  		  		  		  	


  
 D-13 








 EXHIBIT E 

FORM OF 2035 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.  
 GILEAD SCIENCES, INC. 

 

							
	 No.         
	 		  	 	CUSIP NO.375558 BG7.	  
		 		  	 	$                     	  

 Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the
State of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered
assigns, the principal sum of                      DOLLARS ($            ), as revised by
the Schedule of Increases or Decreases in Global Security attached hereto, on September 1, 2035 and to pay interest thereon from September 14, 2015 or from the most recent Interest Payment Date to which interest has been paid or duly
provided for, semi-annually on March 1 and September 1 in each year, commencing March 1, 2016, at the rate of 4.600% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the February 15 or August 15
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable 


  
 E-1 








 
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a
Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any
other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Trustee maintained
for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Authentication. Unless the certificate of authentication hereon has
been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.  

  
 E-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	GILEAD SCIENCES, INC.
		
	By:	 	  

		 	 Name:
 Title:



 [Global 2035 Note] 

  
 E-3 








 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

									
	Date of authentication:	 		 		 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as
Trustee

					
		 		 		 	By:	 	  

		 		 		 		 	Authorized Signatory


  
 E-4 








 [FORM OF REVERSE OF 2035 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fifth Supplemental Indenture dated as of September 14, 2015 (herein called the “Fifth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,000,000,000. The Company may at any time issue additional securities under the Indenture in
unlimited amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject
to redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 25 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
 E-5 








 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 
 “Independent
Investment Banker” means the Reference Treasury Dealer appointed by the Company. 
 “Reference Treasury Dealer”
means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC, their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to
be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

The Securities of this series are also subject to redemption at the Company’s option, at any time on or after March 1, 2035, in
whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the records of the Registrar, at a Redemption Price equal to 100% of the principal amount
of the Securities to be redeemed, plus accrued and unpaid interest to the Redemption Date. 
 In the event of redemption of this Security in
part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 

Change of Control. If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem
the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof), of each Holder’s Securities pursuant to the offer described below (the
“Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued
and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the rights of Holders of Securities on the relevant record date to receive interest due on the
relevant Interest Payment Date. 
 Within 30 days following any Change of Control Triggering Event or, at the Company’s option,
prior to any Change of Control but after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the 

  
 E-6 








 
transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Securities on the date specified in the notice, which date
will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required herein and described in such notice. The Company must comply
with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in
connection with the repurchase of the Securities as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be
required to comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control provisions herein by virtue of such conflicts.  

On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

(a) accept for payment all Securities or portions of Securities properly tendered, and not validly withdrawn, pursuant to the Change of
Control Offer; 
 (b) deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities or
portions of Securities properly tendered and not validly withdrawn; and 
 (c) deliver or cause to be delivered to the Trustee the
Securities properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Securities or portions of Securities being purchased by the Company. 

The Paying Agent will be required to mail promptly to each Holder who properly tendered Securities the purchase price for such
Securities and the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any;
provided that each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof.  

Notwithstanding the foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the
occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for such an offer made by the Company and the third party purchases all such
Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 

For purposes of the foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 

“Capital Stock” means the capital stock of every class whether now or hereafter authorized, regardless of whether such
capital stock shall be limited to a fixed sum or percentage  

  
 E-7 








 
with respect to the rights of the holders thereof to participate in dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of such
corporation. 
 “Change of Control” means the occurrence of any of the following: 

(a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or
more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other
than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction (including, without limitation, any merger or
consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the “beneficial owner” (as defined in Rule
13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed,
measured by voting power rather than number of shares; 
 (c) the Company consolidates, or merges with or into any person, or any person
consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property,
other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any
direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 
 (d) the first day on which
a majority of the Company’s members of its board of directors are not Continuing Directors; or 
 (e) the adoption of a plan relating
to the Company’s liquidation or dissolution. 
 Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be
considered to be a Change of Control if (a) the Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the
holding company are substantially the same as the holders of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more
than 50% of the Voting Stock of such holding company. 
 “Change of Control Triggering Event” means the occurrence of both
a Change of Control and a Rating Event. 
 “Continuing Directors” means, as of any date of determination, any member
of the Company’s board of directors who (a) was a member of such board of directors on September  

  
 E-8 








 
14, 2015 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the Continuing Directors who were members of such board of
directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a director). 

“Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected
by the Company.  
 “Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s
Corporation, and its successors. 
 “Rating Agencies” means (a) each of Moody’s and S&P; and
(b) if any of Moody’s or S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating
organization” within the meaning of Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a replacement agency for Moody’s or S&P, or both
of them, as the case may be. 
 “Rating Event” means, with respect to the Securities, the rating on the Securities
is lowered below Investment Grade by each of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the
occurrence of the Change of Control (which 60-day period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and
its successors.  
 “Voting Stock” means, with respect to any specified person as of any date, the Capital
Stock of such person that is at the time entitled to vote generally in the election of the board of directors of such person. 
 The
Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth
in the Indenture, which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 
 No
reference herein to the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security
at the respective due dates, place and rate, and in the Currency herein prescribed. 

  
 E-9 








 Default and Remedies. If an Event of Default with respect to Securities of this series
shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of the Securities at the time outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time
outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by
the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not
notation of such consent or waiver is made upon this Security. 
 Denominations; Transfer and Exchange. As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer at the office or agency of the Company in any
place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or
the Holder’s attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or
transferees.  
 The Securities of this series are issuable only in registered form in denominations of $2,000 and any integral
multiple of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor
of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made to a Holder for
any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Persons Deemed Owners. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.  
 Miscellaneous. The Indenture and the Securities, including this Security, shall be
governed by and construed in accordance with the laws of the State of New York. 

  
 E-10 








 All terms used in this Security and not defined herein shall have the meanings assigned to them
in the Indenture. 
 Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company
has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers as printed on the Securities, and reliance may
be placed only on the other identification numbers printed hereon. 
 Unless the certificate of authentication hereon has been executed by
or on behalf of the Trustee by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 E-11 








 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 

					
	(Please Print or Typewrite Name and Address, including Zip Code, of Assignee)

  

					
	
	 the within Security of Gilead Sciences, Inc. and
                     hereby does irrevocably constitute and appoint

 

	Attorney to transfer said Security on the books of the within-named Company with full power of substitution in the premises
		
	Dated:	 	  

		
	Signature	 	  

	
	NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security in every particular, without alteration or enlargement or any change whatever.
		
	Signature Guaranteed:	 	  

	
	NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or participant in a “signature guarantee program” (e.g., the Securities Transfer Agents
Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program).


  
 E-12 








 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of

Exchange
	  	Amount of increase in
Principal Amount of
this Global Security	  	Amount of decrease
in Principal Amount
of this Global
Security	  	Principal Amount of
this Global Security
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee
		  		  		  		  	


  
 E-13 








 EXHIBIT F 

FORM OF 2046 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.  
 GILEAD SCIENCES, INC. 

 

							
	No.         	 		  	 	CUSIP NO.375558 BD4	  
		 		  	 	$                     	  

 Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the
State of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered
assigns, the principal sum of                      DOLLARS ($            ), as revised by
the Schedule of Increases or Decreases in Global Security attached hereto, on March 1, 2046 and to pay interest thereon from September 14, 2015 or from the most recent Interest Payment Date to which interest has been paid or duly provided
for, semi-annually on March 1 and September 1 in each year, commencing March 1, 2016, at the rate of 4.750% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the February 15 or August 15
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable 


  
 F-1 








 
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a
Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any
other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Trustee maintained
for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Authentication. Unless the certificate of authentication hereon has
been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.  

  
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 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	GILEAD SCIENCES, INC.
		
	By:	 	  

		 	 Name:
 Title:



 [Global 2046 Note] 

  
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 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

							
	Date of authentication:	 		 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as Trustee

				
		 		 	By:	 	  

		 		 		 	Authorized Signatory


  
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 [FORM OF REVERSE of 2046 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fifth Supplemental Indenture dated as of September 14, 2015 (herein called the “Fifth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $2,250,000,000. The Company may at any time issue additional securities under the Indenture in
unlimited amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject
to redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 30 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
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 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 
 “Independent
Investment Banker” means the Reference Treasury Dealer appointed by the Company. 
 “Reference Treasury Dealer”
means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC, their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to
be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

The Securities of this series are also subject to redemption at the Company’s option, at any time on or after September 1, 2045, in
whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the records of the Registrar, at a Redemption Price equal to 100% of the principal amount
of the Securities to be redeemed, plus accrued and unpaid interest to the Redemption Date. 
 In the event of redemption of this Security in
part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 

Change of Control. If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem
the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof), of each Holder’s Securities pursuant to the offer described below (the
“Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued
and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the rights of Holders of Securities on the relevant record date to receive interest due on the
relevant Interest Payment Date. 
 Within 30 days following any Change of Control Triggering Event or, at the Company’s option,
prior to any Change of Control but after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the 

  
 F-6 








 
transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Securities on the date specified in the notice, which date will
be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required herein and described in such notice. The Company must comply with
the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in
connection with the repurchase of the Securities as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be
required to comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control provisions herein by virtue of such conflicts. 

On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

(a) accept for payment all Securities or portions of Securities properly tendered, and not validly withdrawn, pursuant to the Change of
Control Offer; 
 (b) deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities or
portions of Securities properly tendered and not validly withdrawn; and 
 (c) deliver or cause to be delivered to the Trustee the
Securities properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Securities or portions of Securities being purchased by the Company. 

The Paying Agent will be required to mail promptly to each Holder who properly tendered Securities the purchase price for such Securities and
the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any; provided that
each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof. 
 Notwithstanding the
foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise
in compliance with the requirements for such an offer made by the Company and the third party purchases all such Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any
Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 
 For purposes of the
foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 
 “Capital Stock”
means the capital stock of every class whether now or hereafter authorized, regardless of whether such capital stock shall be limited to a fixed sum or percentage 

  
 F-7 








 
with respect to the rights of the holders thereof to participate in dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of such
corporation. 
 “Change of Control” means the occurrence of any of the following: 

(a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or
more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other
than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction (including, without limitation, any merger or
consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the “beneficial owner” (as defined in Rule
13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed,
measured by voting power rather than number of shares; 
 (c) the Company consolidates, or merges with or into any person, or any person
consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property,
other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any
direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 
 (d) the first day on which
a majority of the Company’s members of its board of directors are not Continuing Directors; or 
 (e) the adoption of a plan relating
to the Company’s liquidation or dissolution. 
 Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be
considered to be a Change of Control if (a) the Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the
holding company are substantially the same as the holders of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more
than 50% of the Voting Stock of such holding company. 
 “Change of Control Triggering Event” means the occurrence of both
a Change of Control and a Rating Event. 
 “Continuing Directors” means, as of any date of determination, any member of the
Company’s board of directors who (a) was a member of such board of directors on September 

  
 F-8 








 
14, 2015 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the Continuing Directors who were members of such board of
directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a director). 

“Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected
by the Company.  
 “Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s
Corporation, and its successors. 
 “Rating Agencies” means (a) each of Moody’s and S&P; and (b) if any
of Moody’s or S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the
meaning of Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a replacement agency for Moody’s or S&P, or both of them, as the case may be.

 “Rating Event” means, with respect to the Securities, the rating on the Securities is lowered below Investment Grade by
each of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the occurrence of the Change of Control (which
60-day period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and its
successors. 
 “Voting Stock” means, with respect to any specified person as of any date, the Capital Stock of such person
that is at the time entitled to vote generally in the election of the board of directors of such person. 
 The Indenture contains
provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture,
which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 
 No reference herein to
the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security at the respective due
dates, place and rate, and in the Currency herein prescribed. 

  
 F-9 








 Default and Remedies. If an Event of Default with respect to Securities of this series
shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of the Securities at the time outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time
outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by
the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not
notation of such consent or waiver is made upon this Security. 
 Denominations; Transfer and Exchange. As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer at the office or agency of the Company in any
place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or
the Holder’s attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or
transferees.  
 The Securities of this series are issuable only in registered form in denominations of $2,000 and any integral
multiple of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor
of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made to a Holder for
any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Persons Deemed Owners. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.  
 Miscellaneous. The Indenture and the Securities, including this Security, shall be
governed by and construed in accordance with the laws of the State of New York. 

  
 F-10 








 All terms used in this Security and not defined herein shall have the meanings assigned to them
in the Indenture. 
 Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company
has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers as printed on the Securities, and reliance may
be placed only on the other identification numbers printed hereon. 
 Unless the certificate of authentication hereon has been executed by
or on behalf of the Trustee by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 F-11 








 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 

					
	(Please Print or Typewrite Name and Address, including Zip Code, of Assignee)

  

					
	
	 the within Security of Gilead Sciences, Inc. and
                     hereby does irrevocably constitute and appoint

 

	Attorney to transfer said Security on the books of the within-named Company with full power of substitution in the premises
		
	Dated:	 	  

		
	Signature	 	  

	
	NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security in every particular, without alteration or enlargement or any change whatever.
		
	Signature Guaranteed:	 	  

	
	NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or participant in a “signature guarantee program” (e.g., the Securities Transfer Agents
Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program).


  
 F-12 








 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of

Exchange
	  	Amount of increase in
Principal Amount of
this Global Security	  	Amount of decrease
in Principal Amount
of this Global Security	  	Principal Amount of
this Global Security
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee
		  		  		  		  	


  
 F-13