111111111111111111111111111111111111111111111111111111111111 • 

OTS0200488 

One Source. One Search. One Solution. 

USEPA STATUS REPORT: 

HEXABROMOCYCLODODECANE WITH ATTACHMENTS 

21 JUN 1978 

oowntoadin9··· 

- U.S. Department of Commerce 

National Technical Information Service 
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~;/"\. U.S DEPARTMENT OF COMMERCE 

. l!J' . Technology Administration 

\ 

• · / National Technical Information Service 

......., .,. Springfield, VA 22161 
COOING FORM FOR SRC INDEXING REVISED 10115/66 

ACLITE INHALATION TOXICITY STUDY IN RATS WlTH 

HEXABROMOCYCLODODECANE WITH ATTACHMENTS AND COVER LETTER 

DATED 042478 

HEXABROMOCYCLODDDECANE 
VELEIICCI!.,. CHEMICAL CClAPI:IIRATIDI\I 

sa1 EAST OHIO STREET • CHICAGO. lt.UNCI6 60611 • 312•670u4fiOO 

Director of the Office of 

Toxio Substances (WH-·557) 

u.s. Environmental Protection Agency 

401 M Street, s.w. 

Washington, D.C. 20460 

April 24, 1978 

Re: Firemaster 100, trade name for 

hexabrorr.ocyclododecane, CAS No .. 11:3194-55-61 

Dear Sir: 

The attached document is submitted for your files and in 

compliance with TSCA section 8(e) if the latter is necessary. 

In summary, the document reports the results of a laboratory toxicology study. 

For the record, the document is identified as follows: 

"Acute Inhalation Toxicity study in Rats", IRDC #163-500, 

April 10, 1978. 

We make no judgment that this document contains information concerning a substantial risk. We reserve our right to 

contest the propriety of TSCA section 8 (e). · 

TRL:eh 

Enclosure 

Sincerely, 

VELSICOL CHEMICAL CORPORATION 

Manager, 

L~ue-o7 RegUlatory Activities 

Environmental sciences and 

Regulatory Activities 
•· 8'8-1'6 DO I ~7 

International Research and Development Corporation 

SPONSOR: 

COHPOUND: 

SUBJECT: 

Velsicol Chemical Corporation 

FM 100 Residue 

Acute Inhalation Toxicity 

5 tudy in Rats . 

Basil K~ J ~,.Leong , . D. 

Director of Inhalation Toxicology 

Approved by: D, Clifford Jessup, Ph.D,'" . . . . . · . -

-·~ :-:-: ~~.-.. ~- ..... ,:::. ~ :=~-~-~'i~.;.!\R_~~~':.,~tt-F,~:;D?:;:17~-~£lr.:-·of:;:·~~s~;c1l-~-.. == ·.----~- -=-~-~~=--·:~ ;·:;;-~~::,-;;~;~;._;:-~: _::..:_ -~_-;:~:;:.~~=;-~~ ;~;;;. 

Date: April 10, 1978 

153:..soo 
·. 

International Research and Development Corpor:_ation ,, .... 

Page 1 

I. SYNOPSIS 

Inhalation exposure of rats for 4 hours to a vapor and aerosol 

aemosphere of FM 100 Residue, at a calculated concentra~ion of 22~9 

mg/1, resulted in dyspnea, salivation, lacr~tion, nasal discharge, 

eye squint and body weight loss. One female rat died on day 3 of 

the postexpasure period. Necropsy of the dead female rat revealed 

dried blood aroUnd the nares, patchy red areas on the lungs, and an 

air distended stomach filled with yellow liquid. The remaining 9 

rats recovered by day 14 of the postexpoSure period. 

163-500 
International Research and Development Corporation 

Page 2 

II. COMPOUND 

The compound was received from the V.elsicol Chemical Co:z:poration, 

Chicago, Illinois on .Tuly 12, 1977. 

It yas received and identified as follows: 

Compound 

Identification 

FM 100 Residue 

Flammable liquid NOS 

ATT: C. Calo 

113322 77. 901 

163-500 

Desc:ript.ion 

brown liquid 

with off white 

residue at bottom 
c 

International Research and Development Corporation 

·."":" 

Page 3 

III. PROCEDURE 

A. AlUMAL EXPOSURE: 

Five male and 5 female Charles River CD rats were used in the study 

of the compound. The ma,le rats weighed from 200_ta_202._&!~L'ffi'l:. tl:l~ 

females from 230 to 232 g1:ams. The 'f_ats we1:e housed ind:l:vidually in 

wire-mesh cages and were kept throughout the pre- and postexposure periods in a temperature and humidity controlled room in accordance with 

standards Outlined in the uGuide For the Care and Use of Laboratory 

Aoimals; DHEW No. (N.I.H. 74-2.3) 1974". Pudna Laboratory Chow and 

water wei~ supplied ad libitum except when the rats were in the expo- .\1 -

sure chambe:c . 

During exposure, che rats uere caged individually in compartmented 

t.:ire-mesh exposure cages.. The cages were placed ~i. a 160-liter, cubical, 

stainless steel and glass chamber. A constant ch~ber airflow was main- -- tained by means of a rotary centrifugal air pump located at tha exhaust 

side of ehe chamber. The chamber exhaust was filtered with an activated 

charcoal filter and a Cambridge Absolute® filter before being discharged outside of the labol:atory. 

B. OBSERVATIONS: 

:-_::.;.::.:-::~~::~0bseP~<,L.t-:l.ons;:.fo.r ~-pharmaco toxi:c' 'sigris :and· inO:rtali ty :we:r.e:·:n'lad.~.~. d,p~_ing~?.~·~:.: 

:=-;;;ci"-~~:;i.it-~; foil~~g t~~--i"h~ui: ex-po~ur~ ;er-ic~ a~~ d-,;-;iftii~~ ""~ -"'--;::: 

after for 14 days. Individual body weights were recorded prior to the 

4 hour exposure and periodically thereafter in order to detect any 

latent effects following the e.~osure. All rats that died during the 

experimental period we1:e necropsied. The 1:ats which survive_d the experimental period were sacrificed and discarded. 

C. VAPOR ATMOSPHERE: 

The vapors and aerosols of the compound were generated by metering 

® 

'fhe liquid with a ft1I Lab Pump into a positive pressure atomizer 

located near the chamber air inlet, at the to~ of the 9xposure cha~be~~ 

~·;r'~ 

163-500 
1nternational Rese(lrch and Development Corporation 

Page 4 

An air pressure of 10 psig, with an airflow rate of 8 1/min, was 

applied to the atomizer which aerosolized ths liqui.d for rapid 

vaporization" 

The vapors and aerosols emerging from the atomizer were 

diluted by the incoming chamber air at the rate of 12 l/min to 

the desired concentration. The concentra~ion of the compound 

(22.9 mg/1) in the chamber atmosphere was calculated from the 

ratio of the rates of liquid dissemination (458.3 mg/min, when 

the specific gravity of the compound was gravimetrically deter~ 

mined to be 1.2597) to the total chamber airflow (20 limin, the 

volume of air ejected from the atmoizer plus the vo~ume ~f make-up 

air). 

163-500 
.. lnternational Research and Development Corporation 

Page 5 

IV. RESULTS 

A. ANI!:IAL OBSERVATIONS: 

The immediate response of the rats to the exp_erimeri.tal: atmosphere 

was an increase of activity· in preening. After several minutes of exposure~ the rats began to settle down~ After 30 minutes of exposure a 

few rats exhibited eye squint, slight dyspnea, salivation, lacrimation 

and nasal discharge. As the exposure continued more rats developed the 

aforementioned symptoms. The slight dyspneic condition changed to m~rked dyspnea in some rats. After 4 hours of exposure all the rats exhibited eye squint~ Six rats had slight dyspnea while 4 rats were obserVed 

with marked dyspnea~ On day 1 postexposure, all rats exhibited a -s~ight 

or a marked dyspneic condi~ion, with one male rat exhibiting salivation. 

On days 2 and 3 postexpOsure, the dyspneic condition changed to gasping 

-in all male rats and 2 of the female rats. One fema1e rat died OiL day 

_3 postexposure and all of the remaining rats had a significant body 

weight loss. Following day 3 postexposure, all of the surviving rats 

appeared to begin to recover and gain weight. By the end of the ~perimental period, the 9 surviving rats appeared normal. The individual 

body weights of the rats recorded during the experimental period are 

':0:0~-==-.:.:':'~">:,:. c:·:o'tr~_s<i!:~~il:l.;,1_!;ib~e: ·1; 

B. ·· i-i6R.'fAI.iri·; ' 

one female rat died on day 3 postexposure. 

C. GROSS NEcROPSY: 

Gross necropsy of the dead rat revealed dri"ed blood around the naies, 

patchy red areas on the lungs and an air distended stomach filled with 

yellow liquid. 

163-500 
' 

_":::= 

FH 100 Residue: 

TABLE 1. 

Calculated 

Concentration. 

Rat 

Number 

22.9 mg/1' 

77882 

77883 

77884 

77885 

77886 

17887 

77888 

77889 

77890 

77891 

163-500 

Sex 

M 

l:l.' 

·k 

H 

H 

F 

F 

F 

F 

F 

{~, 

.. , I ·!; L, 

,, II H,IH· 

'\'I' 

A~~~e 

Inhalation Toxicity Study in Rats. 

' ' 

J:;.j) Individual Dody Weights, Grams. 

. ' ' : ~ q-~n-

/ .l!; PreexpoSUre 

0 ';jl' 

J.~ 

i I 

... 'Fi'l' 

.... \ Li !, zo'o•' 

i~~li' 2 ~. : .w,: 

1~~. 

:13o! 

2;)01' 

232!' 

2:1dl 

2J9!• 

':;":. 

.,. 'I. ~ !~1 ~ ; " . 

... 

I 

!:;!' 

I\! ."I:· 

::,::, .. t:·,· ·!;• 

1('5, 

'''Ti 

!··;~( 

i.l.'l'i; I_::) 

!I·Hi 

,!:Jiff ;;.q·v 

l :'f;l: .. ::! 9 ; !':·,, 

I i !• 

'I I 1-

1 I;· 

2 

160 

150 

164 

154 

159 .. 

204 

214 

Died 

200 

210 

_.,,·f 

'.l. 

.-,_.c 

·Pastexpo~ur~ (pays) 

4. 6 

164 

153 

182 

163 

163 

196 

220 

217 

220 

,?--....--

(! ._, 

·:":-_ \\ 

'--~. 

·. c {l. 

·,\ II\ 

·~ 

_,.,__:;.~,:.:::::-::: .-:;;,_':'_)· 

185 

170 

190 .. 

180 

184 

210 

22# 

223 

223 

2

2

2

2
UNITED STATE? ENVIRONMENi"AL PROTECTION AGE\'lCY 

WASHINGTON. o.c,' '20460 : .,.;::.· • · 

. ' 

APR 2 7 1978 

.. --~ 

Mr. Thomas R. Loy Manag~r, R~gulatory Activities 

Velsicol Chemical Corporation 

341 East Oh.io Street · Chicago, Illinois 60611 

Dear Mr. Loy: 

:': ~· '=' -, ~ 

........ ·~-

·.: -~.: ·-

;,. 

·P.Fl3':~C?.E OF TOXIC SU~ANCES . 

: ','•! ' •· 

.. This W:ill acknowledge receipt' ~f your letters of 

various dates transmitting data to EPA under Section B(e) 

• of the Toxic Substances Control Act. For your information, 

your submissions have been assigned document control numbers 

which are listed on the attached sheet. Any future corres~ 

pondence regarding these notices should reference the perti- · · nent document control number and .be directed to the OTS 

Document Control Officer, Chemical .Information Division, 

Office of Toxic Substances (TS-793), Environmental Protection Agenc"y, Washington,· D.c.· 20460. 

Sincerely~ 

i · ... l 

'!' . ',, 

Joan Urquhart . OTS Document control officer, 

·-:.':.: 

,:_·:··:. ' .: :; 

. . . )' ~ 

Attachmsmt 

··:: --
4/17/78 . 

4/17/78 

4/.17/78 

4/lB/78 

4/24/7~ 

4/24/78 

Submission: ' 

letter and OSHA/ 

NIOSH correspon- dence (Tris) · 

letter and memo 

(undetermined 

cause) 

letter and study · (FM BP4-A) 

. . . 

FM 100 

letter and memo 

:.:··-:·: " · 1Jocumen·t ·Cont·rol Number 

.. 

SEHQ-0478-0129 

SEHQ-0478-0136. 

SEHQ-0478-0137 

8EHQ-0478-0l38P .. 
CODING FORM FOR SRC INDEXING REVISED 10/15186 

OTS0200488 .. 

USEPA STATUS REPORT: HEXABROMOCYCLDDODECANE WITH ATTACHMENTS 

HEXABROMOCYCLODODECANE 
UNITED STATES ENVIRONME~TAL fiROTECTION AGi:«CY 

DATeo June 21, 1978 (Revised May 10, 1979) 

SUOJeCTo Status Report llEJiQ-0478-0137 

Approved'---'-~--

PROUr Joseph J. Merenda,. Acting Director 

Assessment Division, OTE/OTS (TS-792) 

Revision 

Needed 

TOr Warren R. Muir, Deputy Assistant Administrator 

for Testing and Evaluation, OTE/OTS (TS-792) 

Submission Description 

Acute inhalation toxicity of FM 100 (hexabromocyclododecane) in rats. 

Submission Evaluation 

The weakness of. this study is that it was not done on F.M 100 but an a 

residue which contains a ilammable liquid (FM 100 presumably has low flammability; therefore, so~ other material must also be present). Iu 

this instance, the absence of controls is not of as great a concern t~ 

as the fact that the animals showed dyspnea. This could be dtie either to reflex nervous sytem effects or to direct irritant effects on the 

tracheobronchial tree and/or the lungs. The squinting suggests that there was considerable irritation. The fac:t that effer:ts"'·persisted 

beyond the exposure period and that there was considerable loss in body 

weight suggests that there was pulmonary damage. The dry blood seen 

around the nose and in the passage~ay of the 'lungs at'·~·.arit:opsy suggestS 

that irritant injury had occurred. The most important point at this ti.me concerns an aclequate analytical characterization of the test compotmd. 

Current Production and Use 

Hexabromocyclododecane (Hl!CD) is listed :!.n the Directory of Chemical Producers; thus indicating that it is produced in commercial quantities· (>1;000 lb/yr}. HBCD is used as a fire retardant in copolymers of styrene with acrylonitrile, N-vinylpyrrolidlne, divinylbenzene, methylacrylate, poly (methyl methacrylate}, or polyethyl.ene. It is also· used as· a fire retardant in molded and foamed thermoplastic polystyrenes and in polypropylene- based molding compositions. When incorpOrated into these plastics. HBCD · 

imparts a self-extinguishing property to th~ material. 

NOTE: This status report is the result of. a preliminary. staff' e~'\l~t:ian of information submitted to EPA under Section l!(e)_ of_ TSCA; · . ·. ';,, 

Statements made herein are not to be r~garded as,,.express~lll:i'>, 

finsl Agency poUcy or intent .with ,respect ·to ·this·· partii':uliiri,. chemical. Any re_view of dui ·.status· repor:t .·shQti.ia · tak:e· :.:tii'tO:t.·, ·· '· consideration the fact that :It inay be •lias~cL on "!i'tieO!t>Plet'!' )\>: infotmation. · · .... · · ·c - ····-~ • ··.· ·· •·. •;,;~·t:'' ·"·· 

EPA FCA..,_ UZO..& IREV. So7Gl ,214 . , _ .',>~:'·\)- ,,;,·,;;:·: ·,·-t.i~.:.z.'. ' .· . . . .. - ~. ;. ·;: ',.- -
HBCD is also used in the production of adhesives used for cementing 

(lu~ing) polystyrene foam sheets. This use arises from its ability to 

reduce the molding time necessary for cellular polystyrene particles to 

form into a compact foam block • 

. , 

Comments/Recommendations 

Several other subtnissions have been received 6~'FM 100 (BEHQ-0278'-0051; 

SHBQ-0278-0065; SEHQ-0278-0088). The chetnical tdll be evaluated as pari: 

of the Assessment Division's ongoing study of flame retardaUt teChnology. 

FM 100 may be an environmentally persistent compound. 

(a) This submission, like others, was deficient in a number of areas. 

The notifier should be asked to provide adequate analytical data on 

the composition of the Ddxture. tested, gLoss fin'dings On death, 

clinical observations, and physical-chetnical data on the test 

substance. 

(b) This submission should be referred to NIOSH and OSHA. 

(c) The submitter should be asked to.support his contention tbat the 

information presented in this submission reasonably supports a 

conclusion of substantial risk. 

'';.·· ·.: 

215 . ' .. 

,;.'. 
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, P.C. 20460 

Mr. Thomas R. Loy 

Manager, Regulatory Activities 

Velsicol Chemical Corporation 

341 East Ohio Street 

Chicago, Illinois 60611 

Dear Mr. Loy: 

~I 

OFFICE OF' TOXIC SUBSTANCES 

The Office of To~ic Substances has performed preliminary 

evaluations of your submissions (identified in Attachment I) 

under section S(e) of the To~ic Substances Control Act (PL 

94-469). The enclosed status reports are the results of 

those evaluations; however, these reports do not necessarily 

represent EPA's final conclusions on these submissions. 

Submission of the information contained in the notices 

listed in Attachment I does not appear to be required under 

section B(e) of the Toxic Substances Control Act. Please 

refer to the March 16, 1978 Federal Register publication 

entitled "Statement of Interpretation and Enforcement 

Policy; Notification of Substantial Risk" (43 FR 11110) for 

guidance as to the types of information which should be 

submitted.·under section B (e). If, after rev.iewing the 

policy statement and reconsidering the information contained 

in these,notices,·you conclude that any or all of the submiss~ons listed in Attachment I are appropriate B(e) 

submis¢icns, please respond to the information requests pert~~ning to those submissions. These information requests 

can 5e found on the attachment entitled nRequests for 

Further Information." In cases where you conclude .in 

retrospect that an earlier submission is not appropriate 

under section B(e), please notify EPA of that decision. 

In responding to the nRequests for Further Information,~ or 

in otherwise communicating with EPA regarding a previous 

submission under section B(e), please refer to the EPA 

Document Control Number assigned to that submission. If 

further information is to be provided on more than one 8(e) 
2 . .:; 

submission, please use separate sheets for each. As in the 

case of initial S(e) submissions, all responses will be. 

placed in the public file unless conficientiali.ty is <:::laimed according to the procedures outlined in Section X of the 

March 16, 1978 policy statement. Any confidentiality claims 

should be supported by submission of information as described in the enclosed item titled' "Support Information for Confidentiality Claims." Responses to the "Requests for further 

Information" should be received by the Docwnent Cont~:ol 

Officer within 45 working days of the date of this letter. 

Enclosures 

J. Merenda 

rector 

ment Division 
Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No;: 

Subject chemical {s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No.: 

Subject chemical(s): ... tiate submitted: 

EPA Document Control No.: 

·._, 

S~&bject chemical(s}: 

":: Date submitted: 

EPA· Document Contra 1 No. : 

Subject chemica1(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical{s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Attachment I 

, ::>ft.tJt '. ':' / ·:~ .... , 

PCL bottoms, hex PCL bottoms 

9/23/7'7 . BEHQ-0977-0004 

dibromoethy1 acetate 

"fi/23/77 

BEHQ-0977-0005 

dicyclopentadiene acrylate 

11/7 {77 

BEHQ· 1177-0017 P 

benzoic acid 

ll/7/77 

BEHQ-1177-00lBP 

unknown 

l/13/78 

BEHQ-0178-0031 P 

rnethy1amino acetaldehyde dirnethylacetal 

3/21/77 

BEHQ-0178-0036 

polypropylene glycol 

2/9/77 

BEHQ-0178-0041 

Polyvel M-106 polymer 

9/26/77 

BEHQ-0278-0050 

FM-100 

9/26(77 

BEHQ-0278-0051 

chlorendic anhydride ,, /30/77 

BEHQ-0278-0058 

chlorendic anhydride 

11/30/77 

BEHQ-027!1-0059 

MC-948 

12/2/77 

BEHQ·!IZ78-0060 
Subject chemical(s): Date submitted: EPA Document Control No.: 

Subject chemica1(s): Date submitted: EPA Document Control No.: 

Subject chsmica1(s): Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: EPA Document Control No. : 

Subjeci chemical(s): Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Da;te submitted: EPA Document Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No.: 

Subject chemical(s): ..... Date submitted: 

EPA O~~ijment Control No.: 

' ~tibject chemica1(s): · :. Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No.: 

methendic anhydride, maleic anhydride: 12/16/77 .. 8EHQ-0278-0053 •.' 

hexabromocyclododecane (FM-1 OO) 12/19/77 . 8EHQ·0278-0065 

VC-935~ 

12/9/77 

BEHQ-0278-0066 

diisopropylamino ethyl chloride hydrochlo1 1/11/78 

8EHQ-0278-0067P 

2 ,3-dibromopropan.ol ·· 1/19/78 "'" 

BEHQ·D278-0068 

HCS-3510 

2/15/78 

BEHQ-0278-0072 

CN-110-109 

2/17/78 

8EH~0278-0074 

unknown 

2/7/78 

8EHQ·0278-0075P 

phosgene 

2/7/78 

8EHQ-0278-0076P 

dicyclopentadiene, dicyc1opentadiene a1col 2/8/78 

8EHQ·0278-0077P 

phosphorus ox_ychloride 2/B/78 . 8EHQ-0278-0078P 

phosgene, toluene 

2/8/78 

BEHQ-0278-0079P 

'·: 

·'· 
Subject chemical{s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Doc~ment Contt·ol No.: ::·. 

phosphorus exychloride 

2/10/78 

BEHQ-0278-0080P 

unknown 

2/17/78 ~ 8EHQ-0278-0081P ~ 

Subject chamical(s): dioxins 

Da t<i'lfiiBDil."fteo!:, __ 3/l/7 8 EPA Docul!ient ·control No.: ----,_,c llEilQ-0378-0085 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject :chemical(s}: Da_'te submitted: 

EPA Docum~t Control No.: 

"" Su~fect chemical(s): :-· Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s}: 

Date submitted: 

EPA Document Control No. : 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Fir~qster 6BO 

3/l/7ff',_. -?y-=-' 

BEHQ-037a.::coeo-:=-::--="'""'"·--:·~-- \. 

\I isocyanate dime~ of 5-t-butyl-l,3,4-tKiadazol-2~yl 

3/1/78 t BEHQ-0378-0087 ~-

residue from hexabromoeyclododecane 

3/l/78 

BEHQ-0378-0088 

chlorinated norbornene derivative 

3/l/78 

8EHQ-0378-0089 

VCC-935A 

3/1/78 

BEHQ-0378-0090 

MC-993 

3/l/78 

8EHQ-0378-0091 

VC-948 

3/1/78 

8EHQ-Q378-0092 

chlordene epoxide 

3/l/78 

BEHQ-0378-0093 

chlorendic anhydride 

3/6/78 

BERQ-0378-0094 

tribromopbenol 

3/6/78 

SEHQ-0378:-0095 
Subject chemical(s): Date submitt.ed: 

EPA DoCume·nt Control No.: 

Subject chemicai(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical ( s) : 

Date submitted: 

EPA Document Control No.: 

su~ject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No,: 

Subject chemica1(s): Date submitted: 

EPA Document Control No.: 

·subjec.t chemical ( s): 

Da:i:e submit ted: 

EPA Docum~t Control No.: 

' •t, 

Subject chemical(s): -· Date submit ted: 

EPA Doc~ent Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No.: 

Subject chemical{s): Date submitted: 

EPA Document Controi No.: 

4 

dicyclopentadiene 

3/7/78 . . 

8EHQ-03iB-0097 :; 

VC··948 

3/7/78 

BEHQ-0378-0098 

MC-984 

3/16/78 

BEHQ-0378-0100 

chlorendic anhydride 3/16/78 

8EHQ-0378-0101 

VCC-935A 

3/16/78 

8EHQ-0378-0103 

MC-984 

3/27/78 

8EHQ-0378-0107 

methanol 

3/27/78 

8EHQ-0378-0l08,~ 

hydroxyaceta1debyde dimethyl acetal 3/27/78 

8EHQ-0378-0lll 

benzene 

.3/27/78 

8EHQ-0378-0112 

methyl acetate 

3/27/78 

BEHQ-0378-0114 

FH-680 

3/31/78 

BEHQ'-0478-0115 :· 

.. : .. :::. 
Subject chemical(s): Date submirted: 

EPA Document Control No~: 

Subject chemica.l(s): Date sul.,mi.tted; 

EPA ,. 

Document Control No.: 

Subject chemical (s): Date subtnitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: EPA Document Control Non: 

Subject chemical(s): 

Date submitted: EPA Document Control No.: 

Subject chemical (s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted; 

EPA Document Control No.: 

Subject cbemical(s): Date submitted: 

EPA Docum8nt Con;rol No.: 

Subjec~ 'l'hemic:al (s): !)ate submi 1: ted: 

EPA Document: ,, .. , Control No.: 

' Subj~ct chemical(s): · :. Date submitted: 

EPA DocUment Control No.: 

Subject chemic:al(s): Date submitted: EPA Document Control No.: 

Subject chemical(i): Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: EPA Document Control No.: 

5 

tetrabromobisphenol A, PNA's 3/31/78 

8EHQ-0478-0U6 

PNA's 

3/31./78 

BEHQ-04 7 8-0117 

unknotm. 

3/31/78 

SEHQ-0478•0118 

~rcmoacetaldehyde dimethyl acetal 

3/31/78 

8EHQ-0478-0ll9 

sodium acet.ate 

3/31/78 

BEI!Q-0478··0120 

dibromoethyl acetate 

3/31/78 

8£HQ-0478-0l21 

PHT~4 

3/31/78, 

8EHQ-047B·Ol22 

vinyl acetate 

3/31178 

8EHQ-0478-0l24 

sodium bromide 

3/31/78 

8EI!Q-047B··Ol25 

bromoacetald,~hyde solution 3/31/78 . 

BEHQ-0478-0126 

chlorendic anhydride 

3/31/78 

8El!Q~0478-0127 

tetrabromobisphenol A (FM BP4-A) 4/17/78 

BEI!Q-0478-0llO 

i 

3-bromo-2, 2-dimethylpropyl-2-chioroetbyl-2-

bromoethyl phosphate 4/17/78 . 

8EllQ-04711-0l3l 

'::. ' ' 

. :·:·. ;: 
Subject chemfcal (s): 

Date s;Jbmi·tted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

S~bject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document ,Coni:rol No.:. 

subject.chemical(s): 

lfl;ite submitted: 

EPA Docum(nt Control No.: 

.f;· 

SuMect chemical(s): ·· Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

.; 6 

MC 935,\. 

4/17/78 

BEHQ-04 78~0J.3Z 

vc 984 

4/18/78. 

8EHQ-0478-0i:l6 

FM 100 

4/24/78 ~ 

8EHQ-0478-0l37V 

DCPD, .DCPD alcohol, benzyl chlodde 

4/24/78 

8EHQ··04 78-0138P 

VC 935A 

5/l/78 

BEHQ-05 78-0141 

FMBP4A 

5/1/78 

8EHQ-0578-0l42 

l-propano1 monoester of tetrabromophthalate 5/1/78 

SEHQ-,:0578-0143 

CN-110-356 

5/1/78 

8EHQ-0578-0144 

vc 948 

5/1/78 

BEHQ-05 78-01.45 

FMPH'l't 

6/5178 

8EHQ-067B-0171 

VEL 4441 

6/2/78 

BEHQ-0678-0172 

MC 984 

6/2/78 

SEHQ-0678-0173 

CN 010-073 

6/2/78 

BEHQ-0678-0174 
Subject chemical(s): 

Dat:e submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted~ 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document COntrol No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject .'chemical(s): 

Date submitted: 

EPA Document·:" Control No.: ., .. ' 

Su9ject chemical(s): 

. :: Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control ~o~: 

Subject: chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject: chemical(s): 

Date submitted: 

EPA Document Control No.: 

7 

CN 110-335 

6/2/78 

BEHQ-0678-0175 

VEL 4083 

6/5/78 

8EiiQ-0678-0176 

DM!C 

6/2/78 

8EHQ-0678-0l7? 

2-bromo-1,1-dimethoxyethane 

6/6/78 

8EHQ-0678-0179 

dicyclopentediene, benzoyl chlorid~ 

6/2/78 

8EHQ-0678-0l80 

dipropylene glycol dibenzoate 6/l/78 . 

BEHQ-0678-0181. 

unknown 

6/6/78 

8EHQ-0678-0l82PS 

2,3-dibromopropanol, FMPiiT4 diol 

6/9/78 

BEHQ-0678-0187 

MC-948 

6/14/78 

8EHQ-0678-0l88 

VC-984 

6/14/78 

8EHQ-0678-0l90 

VC 935A 

6/14/78 

BEHQ-0678-0191 

VEL 3838 

6/19/78 

8EHQ-0678-0193 

VEL 4038 

6/19/78 

8EHQ-067B-0194 
Subject chemica.l(s): 

Date submitted: 

EPA Document Control No.~ 

Subj.rct chemical(s): 

Date subrilitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject cbemi.cal(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Documerit.Control No.: 

Subject chemical(s): 

Date submit ted: 

EPA Document Control No.: 

Subject chemical(s): 

· Date submitted: 

EPA Document,Con"trol No.: 

Subject; ··chemical(s): 

·· ·i>ate submitted: 

EPA Docum€nt Control No,: ... 

·<, 

Su6ject chemical(s): 

·· Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No .• : 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

8 

VEL 4609 

6/19/78 

8EHQ-0678-0l95 

VEL 4578 

6/19/78 

BEHQ-0678-0196 

VEL 3510 

6/14/78 

BEHQ-0678..:0197 

VEL 3947 

6/19/78 

BEHQ-0678'-0199 

dibr:omo··o-·dichlor:obenzene 

6/19/78 

8EHQ-0678-0200 

methyl-m-chlorobenzoate 

6/19/78 

8EHQ-0678-0201 

VEL 4411 

6/23/78 

8EHQ-0678-0203 

PCS 1375 

6/23/78 

8EHQ~0678-0204 

Pol vvel G 100 

6/23/78 

BEHQ-0678-020,5 

Cblorendic anhvdride 

6/15/78 

BEHQ-06 78-0206 

dicvc1opentadiene acrvlate 

6/23/78 . 

BEHQ-0678-0207 

VEL 4582 

6/15/78 

8EHQ-0778-0210 

bromodichloroben~ene (ne.itral oils frem hydi:phsi 7/20/78 

BEHQ-0778-0220 

;.·.• 

:,• .. ·; :. 

-. - ~· .. 

:: 
Subject chemical(s): 

Date sub.,itted: EPA Docum~nt ContrOl"' No.: 

Subject cbemical(s): 

na·te submitted: 

£PA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Sub;ect chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): Date submitted: 

EPA Document Control No,: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document ,Control No.·: 

Subject: 'chemical(s): 

'Date submitted: 

EPA Doc~ent Control No.: 

~f. 

SuDject chemical(s): ' Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: EPA Document Control. No.: 

Subject chemical (s): 

Date submitted: 

EPA Document Control No.: 

Subject chemical(s): 

Date submitted: 

EPA Document Control No,: 

9 

vc 948 

7/20/78 

BEHQ-0778-0221 

DCPD alcohol 

7/19/78 

8EHQ-0778-0222 

methyl-m-chlorobenzoate 

7/19/78 

BEHQ-0778-0223 

VEL 4578 

7/19/78 

8EHQ-0778-0224 

VEL 4441 

7/19/78 

8EHQ-0778-0225 

metbyl-m-chlorobenzoate 

7/19/78 

8EHQ-077B-0226 

tribromophenol,, sodium salt 

7/19/78 

8EHQ-0778-0227 

ethylene dichloride 

7/19/78 

SEHQ-0778-0228 

benzoflex S-552 

7/19/78 

8EHQ-0878-0229 

chlorendic anhydride 7/31/78 

8EHQ-0878-0231 

';,_· .. ; 
0004 

Request.s for :Further Information 

(Submissions identified by iast.four 

digits of Do9ument Control Number) 

Please explain the terms "PCL. Bilttoins" and "Hex PCL 

Bottoms" used in the description of the test· material. 

Please submit complete copi.es of the studies summarized 

in the submission and provide available data concerning the 

puri t.y of the test material. 

Please submit any additional information which is 

relevant to an analysis of the effects described in the your 

submission, e. g., copies of medical reports, corroborati've 

information from other employee complaints, relevant literature, etc. 

Please submit a copy of the company doctor's report on 

this incident. If the employee's condit.ion was diagnosed by 

an allergist, as recommended in your submission, please 

inform 'EPA of his findings. f.' • • • f' :.;;''"- .. ~E 

•• Please provide any available information !'onc:erning 

PO!iJSible causative agent(s). ·:: 

Please provide solubility and volatility date on , methylamine acetaldehyde dimethyl acetal and brolt'.oaeet:.o·· 

aldehyde dimethyl acetal. · ·o · 

:. : 

No additional information is requested at this t;ime. 

--.,·,, . 

.• 

. .-. 
No additional information is requested at this time. c. 

Please provide available analytical data on the com- positions of the mixtures tested (FH-100, Lot 53 and Residue of Lot 3322). Data on the physical/chemical properties of these substances would also be helpful. · · · 

Please provide information on physical and chemical properties of chlorendic anhydride which are relevant to an assessment of hazard to aquatic organisms •. Data on water solubility, rate of hydrolysis to chlorendic acid, pka of chlorendic acid, degradation of chlorendic anhydride and chlorendic acid are examples of the types of information which would be useful. 

0059 

The information on physical/chemical properties re- quested for submission 8EHQ-0278-00SB would also be useful for this submission. 

~Please identify the test material (MC 948) by a · sys.t'ematic chemical name and either a molecular formula or a Stfuctura~ formula • 

.. 

Please submit a copy of your safety data sheet on methendic anhydride and provide the results of any me.dical evaluation conducted on the exposed work~rs. 

Please provide any available data concerning the ' physical/chemical properties of the test substance. Also, ·please report any pathological findings or clinical obser- ,·,/a tions made on the test animals.. · 
-3-

0066 

Please provide the chemical structure of vc S:35A. Information on the purity of the test material and its physical/chemical properties should also be.submitted. Is the test material identical to the commercial substance? If r1ot, please provide the information requested above for both substances. · 

Has Velsicol ever encountered or investigated a dioxin contamination problem with VC 935A? If so, please submit such informatin. 

0067 

Please submit a complete copy of the attending phy- sician's report. 

Please submit a full copy of the study from which the information in this submission was extracted. 

0072 

Please clarify the information concerning the method of dosing and the actual level which the rulimals received. 

QQI! 

.~lease clarify the composition of the mixture tested. Is ~):!e composition of CN-ll0-19 identical to·that listed for the~Fire Master 680 oils? fr 

Please identify by systematic name the chemical(s} which caused the face, neck, and hip'burns when the C220 filter ruptured on December 2~:.;" 1977. · 

No additional information is requestep at this time. 

Please provide the structural foJ:"n\ula for dicylo.,, pentadien alcohol. A.l!i!O please provide. a~;.much :j.nforma,. tion oh the incident reported, as you can, >:ncludl.ng 
-4-

medical reports and follow-up activities. 

No additional information is requested at this time. 

No additional information is requested at this time. 

0080 

No additional information is requested at this time. 

0081 

Please identify the chemical agen(s) causing the complaints, if that information is ~vailable. 

0085 

No additional information is requested at this time. 

0086 

No further.information is requested at this time. 

Please provide information concerning the composition, purity, and physical/chemical properties of the test sub- stance. ~ecause of the text substance's potential for antichqlinesterase activity, you should submit any available inform<~.tion which is relevant to an assessment of that potent,ial. Please submit a copy of p. 18 or the IROC re- por·l;,- ·as it is missing from your original submission. 

ooes' 

~ 

Please provide information concerning the composition and physical/chemical properties of the "FM 100 Residue" which was tested. Of particular interest in this regard is the amount of hexabromocyclododecan present in the residue. Available toxicity date on hexabromocyclododecane would be useful for correlation purposes. 

Please describe any gross patholical findings or clinical observation made on the.test animals. Also, please submit a copy of page 17 of the IRDC report (this page was missing from the report submitted to EPA). 
-5-

No further information is requested at this tinie. 

0090 

No additional information is requested at this time. 

0091 

Please submit the result.s of any gross pathology or histopathology performed on the test animals. Please submit pages 17 and 19 of the "Acute Toxicity Studies in Rabbits and Rats", as these pages are missing from your original submission. 

0092 

Please submit a full copy of the report "VC-948, 77.1467; Acute Oral Toxicity Study in Mice: from the International Res!=arch and Development Corporation, 2-14-78, il63-514. A page was missing from the report as submitted to this office. 

Also please identify the compound by chemical structure specify what the chemical is used for, and the amounts produced and used. 

Please answer the questions raised in .the Toxicological Evaluat~on section of the Status Report of the information is available. 

·.r ... 

No further information is requested at this time. 

0094 

Because of the equivocal results obtained from the BALB/3T.3 mouse lymphoma assay, and the deficiencies in the oral LD. study, please consider repeating these tests, using experimental procedures discussed in tlle "submission evaluation" of the Status Report. 
-6-

0095 

Please identify which tribromophenol isomer(s) was tested and provide any available data concerning the priority of the test substance. ,., 

Please inform EPA of any investigation of potential dioxin contamination of tribromophenol. Desc~ibe any 

minimize 

quality control procedures which have been instituted to dioxin contamination. 

No additional information is requested at this time. 

Please identify, by chemical structure, the chemical VC-948 (bis (tribromoneopentyl) pentaerythrito1 cyclic dyphosphate) • · 

0101 

0103 

----::; 

No additional information is requested at this time. 

No additional information is requested at this time. 

'' Please identify, by chemical structure, the chemical MC~935A (poly (dibromophenylene) oxide). 

0107 

Please provide available information concerning the composition, purity, and physical/chemical properties of the test material. Also, please clarify the dose data-Di.e. what was the concentration of active ingredient administered to the test animals? 

0108 

No additional information is requested-at this time, 
....• ,.,.,_ __ :-'::.., 

.--..• o._, .. 

0111 

No additional information is requested at this time. 

0112 

No additional information is reguested at,this time. 

0114 

No additional in::>rmation is requested at this time. 

No additional information is requested at this time. 

0116 

Please submit a copy of the fish broaccumulation study mentioned in your submission as soon as the study is com- pleted. 

0117 

Please provide more information concerning the com"' position o; the raw materials C-9 and MPB. Also, please describe the chemical nature and use patteras of the resins made frQm these materials. 

EPA should be informed of any subsequent developments in tl'i'is matter. 

OliB 

Please identify the abbrevia't:ed chemical names "DEBA" and "BADMA" by systematic chemical names and molecular formulas or structural formulas. 

Please clarify the relationship of the chemicals noted in BEHQ-0178-0036 and BEHQ-0178-0039 to theBADMA used in this study. Was the BADMA used in the dermal testing iden- tical to the lot used in this study? Is MAADMA known (or likely) to be contaminated with BAD~oA? 
-a:.. 

0120 

No additional information is r.equested at this time. 

Please submit any.available physical/chemical information concerning 

complete properties if dibromoethyl acetate. A 

patterns copy of the study and a discussion of the use for this chemical would also be helpful. 

Please consider retesting sensitive the material using more experimental procedures. 

explain 

Please 

why identi.fy the solvent used in this test. Also, 

soluble this solvent was used. Since the compound is in water, an additional solvent seems unnecessary. 

' 

No additional information is requested at this time. 

No additional information is requeste~ at this time. 

0127 ~ l' 

--.,- . 

. ,,; Please refer to the Comments/Recommendatio;,s th<?'· Status Report section of 

s:j..Ons of for a discussion of appropriate subtid_.s:.. substantial risk. No additional information. requested at 'i'!' this time. 

• 

Please refer the Status Report teratology study. this time. 

to the Submission Evaluation section of for comments on weaknessess iri the pilot No additional information is requested ~t 
No additional information is requested at this.time. 

Please clarify the chemical struCture of MC 935A and provide any available data concerning the purity and phys- ical/chemical properties of this substance. 

0136 

Because of the discrepancy between the two mouse lymphoma assays, please consider retesting so that con- sistent results may be obtained. 

Please provide available data on the composition, purity, and physical/chemical properties of the test substance. Also describe any pathological findings or clinical observations made on the test animals. 

Please submit a copy of the attending physician's i·eport. · ·- f 

., 014:( 

:~ 

·· No additional information is requested at this time • 

• 

Please supply any information on skin sensitization in· an'imals that was available to the dermatologist before the human study was done. 

Also, please =larify what modifications were made to the standard D%·aize test in the skin sensi~ization study. 

No additional information is requested at this· tinie. 
Please clarify the chemical name for CN-llD-356 and provide a structural formula for this compound. Available 

information on production volume and use patterns for this chemical would also be of value to EPA. 

No additional information is requested at this time. 

Please provide data concerning the purity of the test substand and data on the physical/chemical properties (especially water solubility) of the substance. 

Please provide data concerning the composition, purity, and physical/chemical properties of the test substance and submit the results of any gross pathology or histopathology performed on the test animals. Also, please discuss ourrent:, and projected use patterns for VEL 4441 and inform EPA if 

any plans for additional testing on this substance. 

:=. 

0173 

:piease provide any available data concerning the identification of impuritiS$ in MC 984. If no data is ava,;iilable, a discussion of potential impurities would be h~lpful. Also, please answer the questions raised in the "Submission Evaluation section of the status report. 

Please provide data concerning the composition pur;'.ty, and physical/chemical properties of the test substance. Also, please respond to the questions raised in. the "Sub-' mission Evaluation" section of the status report. c 

:; '. 
'-11-

' ' 

0175 

Please provide data ccineerning the ·compositibn, pu.rity, and physical/chemical properties of the test substance and· submit the results of any gross pathology or histopathology_ performed on the test animals. Also, please discuss current and projected use patterns fcir VEL 4441 and inform ·EPA' of 

any plans for additional testing on this substance. 

0176 

Please prov.ide data concerning the composition, purit·y, • and physical/chemical properties of the test substance. Also, please describe the use patterns of this substance. 

0172 

Please provide data concerning the composition, purity, and physical/chemical properties of the test substance. Information related to the compound's stability and hydro• scopicity are particularly important in this case. Also, please describe the appearance of the rats' lungs upon necropsy. Did the lungs show edema or ·hemorrhaging? 

0179 

No additional information is requested at this time. 

0180 . ,.. --.r· .. ;;' No additional information is requested at this time. 

:.:. 

No additional information is requested at this time, 

No additional information is requested at this tiine• 

.Ql!U.· 

Please resolve the confusion concerning the identity of the test substance. Was 2, ·3-dibromopropanol a component,of the test substance? AlsO. provide any available anlytioal .. data on the composition and puri1;Y of the' test substance,· 

.. ;. 

; ' 
.:.12-

No additional .information is requir\i!d at this time. 

Please refer to the Comments/Recommendati"ons the Status Report section of 

submissions for general comments on appropriate 8 (e) and future acti v.i ties. · · 

Please provide any available information concerning composition the and purity of the test material. 

Please submit any available information concerning use pattern the 

data concerning 

of the subject chemical. Also, provide available 

substance. the composition and purity of the test ·. 

0194 

Please submit any available information concerning use pattern \:he 

data 

of the subject chemical. Also, provide available concerning stance.' 

the compostion and purity of the test .sub~ 

.• 

0195:' 

--.; 

:!. -· Please submit any available information concerning use pattern the 

data 

of the subject chemical. Also, provide available concerning the composition and purity of the test substance. 

Please submit any available 'information concerning use pattern the 

data concerning 

of the subject chemical. Also;_provide available 

substance. the composition and purity·of the test · · 
· ..... 

. . 

0197 

Please submit any available information concerning the 

use pattern of the subject chemical. Ailso, prpvide available·· data concerning the composition and purity of· the test substance. · · 

0199 

No additional information iS requested at this time; 

Please identify the "DBDCB isomer'' found on the GC trace. 

Please submit any available information concerning the· 

use patierns of the subject chemical; Also, please respond to the questions raised in the evaluation section of the · status report. 

Please provide any available data cqncerning the·com- position a-nd purity of the test material.~ 

•r . . . . ·''Please submit an accurate chemical identity of PCS 137$, describing a. molecular structure and formula.con- sis-t:ent with a name. Also, please provide:·· analytical data ~ cdncerning the composition and purity of the test material, any available information on its use patterns, and the results of any experimental blood level determinations. 

0205 

. Please provide analytical data concerning the com.;. position and purity of the test material. Also; 'please inform EPA of any plans for further testing-of.~is ina;.. terial. · · · ·· · · 

··' 

·,·,.· 

. ~· 
0206 

Please provide any available analytical data CC)nce'rning 

the identification or characterization of impurities present in the test substance. · 

No additional information is requested at this time. 

0210 

Discrepancies between the chemical name and the melee• 

ular formula have been a recurrent problem with Velsicol 

B(e) submissions. Please clarify this discrepancy .for this 

submission. It is the responsibility of the submitter to 

provide EPA with complete and accurate information, so that 

a proper evaluation of substantial risk can.be made. 

Please proofread future submissions carefully. 

Also, please provide a description of the use patterns 

of this substance. Please provide histopathological find~ · ings on the test animals. If these are not available, 

Velsicol should consider initiation of these studies. 

0220 

Please provide any available informatiqn conc:;erning the · use patterns and/or information of the test compound • 

. . ' 

__ o22rt , · .,, 

:: ' Please provide any available information concerning the 

annual production and uses of the test compound. 

0222 

Please provide any available analytical data concerning the composition and purity of the test material. 

0223 

No additional information is requested at this time. 

' -1 
Please provide a description of the use patterns of Vel 

.4578. 

0225 

Please provide a description of the use patterns of vEL_ 

4441. 

Please provide a description of the use patterns of 

methyl-m-chlorobenzoate. 

0227 

Please address the concerns raised in the Submission 

Evaluation section of the Status Report. 

No additional information is requested at this time. 

Pfease provide the chemical identity of benzofleK S-552 

with 1!!' .. specific structure of molecular formula and chemical 

name.r.. . ' 

··:t, 

.. , 

o:<·3i 

No additional information is requested at.this time •. · 

':.: 
CODING FORM FOR SAC INDEXING REVISED 10f15/S6 

DT902C•04BB 

LETTER FROM VELSICOL CHEMICAL CORPORATION RESPONDING TO 

USEPA LETTER DATED MARCH 16, 1'378 REGARDING INFORMATION ON 

THE POLICY STATEMENT f'1ND DATA WITH ATTACHMENT 
·i 

VELBJCOL CHEMICAL CORPCIRATION 

341 eAST CHIC STREET • CHtCAGO, IWNCtS 60611 • 312~670·-4500 

April 20, 1979 

Mr. Joseph J. Merenda 

Assessment Division 

Office of Toxic Substances (WH-567} 

Environmental Protection Agency 401 M Street, SW 

Washington, D.C. 20460 

Subject: Notification of Substantial Risk 

EPA Letter - Undated 

Dear Mr. Merenda: 

In response to your attached undated letter, Velsicol's Chemical 

Risk Assessment Committee (CRAC} has reviewed EPA's March 16, 

1978 policy statement and the data within these notices. It is 

CRAG's determination that Velsicol does not consider the submissions discussed in your letter to contain evidence of substantial risk. Since Velsicol does not consider these as appropriate section B(e) submissions, with this letter Velsicol 

wishes to formally withdraw the submissions outlined in your 

letter. 

Information -':'equested· by EPA in the attachment entitled "Request 

for Further Information has not been included since Velsicol 

does not consider these as appropriate B(e) submissions.·· This_ 

information will be developed if the Agency wishes to ~ceive 

it .. 

Thank you for your patience in this matter. Please call us if YO\~ have any questions. 

Sincereiy, 

VELSICOL CHEMICAL CORPORATION 

' H. Olav Messerschmidt 

Manager of Pro'duct Registration 

MOM:lb .. • • • • • • • • • • • •• • • • • • •• • • • ~ • .. • • • • • • • • • • • • • •• • ••• • 

• •• • • 4!'•• • • • • • •• •• • -· • ·- ·-· •· • • . .. • • • .. • • • • .... ·• •:.~···' -. ' 
. ,.... . .,.~ 

. ft. 

~ ~' u UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

"« _,_';! WASHINGTON, D.C. 20460 

JAN 2 61979 

Mr. Thomas R. LoyRECEiVED Manager, Regulatory Acti~ities 

'velsi.col Chemical Corporation 341 East Ohio Street 

Chicago, Illinois 60611 

Dear Mr. Loy: 

OFFICE OF TOXIC S~SSTAHCES 

z.he Office of Toxic Substances has performed preliminary evaluations of your submissions (idemti.fied in Attachment I) under section S(e) of the Toxic Substances Control Act (PL 94-469). The enclosed status reports are the results of those evaluations; however, these reports do not necessarily represent EPA's final conclusions on these sqbmissions. 

Submission of the information contained in the notices listed in Attachment I does not appear to be required under section B(e) of the Toxic Substances Control Act. Please refer to the March 16, 1978 Federal Register publication . entitled "Statement of Interpretation and Enforcement Policy; Notifi.cation of Substantial Risk" (43 FR 11110) for guidance as to the types of information which should be submitted under section S(e). If, after reviewing ~~e policy statement and reconsidering the information contained in these notices, you conclude tha~ any or all of the submissions listed in Attachment r are .appropriate S(e) submissions, please respond to the information requests . pertaining to those submissions. These information requests can be found on the attachment entitled "Requests for Further Information." In cases where you conclude in 

retrospect that an earlier submission is not appropriate under section.B(e), please notify EPA of that decision. 

In responding to the "Requests for Further Informq.ti.on," or in otherwise communicating with EPA regarding a previous submission under section S(e), please refer to the EPA 

Document COntrol Number assigned to that submission. If further information is to be provided on more than one B(e) 

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case of initial B(e) submissions, all responses will be 

placed in the public file unless confidentiality is claimed 

according to the procedures outlined in Section X of the 

March 16, 1978 policy statement. Any confidentiality claims 

should be supported by submission of information as described 

in the enclosed item titled "Support. Information for Confi- · dentiality Claims." Responses to the "Requests for Further 

Information" should be received by the. Document Control 

Officer within 45 working days of the date of this letter. 

'J. Merenda 

rector 

ment Division 

Enclosures • 

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