69950 Federal Register / Vol. 65, No. 225 / Tuesday, November 21, 2000 / Notices

496–7056 ext. 270; e-mail:

rambosej@od.nih.gov.

This technology relates to transgenic

knockout mice that may serve as an

animal model for dental disease. Using

gene-targeting techniques, mice have

been created which are disrupted for the

amelogenin gene. These mice lack the

amelogenin protein, which is normally

expressed only in the teeth. Since these

mice lack this protein, they are expected

to mimic an inherited tooth disorder

called ‘‘amelogenesis imperfecta (AI)’’.

AI is an inherited condition that is

transmitted as a dominant trait and

causes the enamel of the tooth to be soft

and thin resulting in discoloration,

disintegration and disfigurement of the

teeth. The damaged teeth are also

susceptible to decay. The amelogenin

knockout mice display an interesting

tooth phenotype. Their maxillary

incisors are chalky white in color and

opaque in appearance.

These changes are associated with

mild attrition of incisor tips and molar

cusps. Detailed analysis of this

phenotype is in progress. The

amelogenin knockout mice may be used

as an animal model to develop

therapeutic approaches to AI.

Transgenic Mouse Model for Tooth

Disorders Such as Dentin Dysplasia and

Dentinogenesis Imperfecta

Drs. Thyagarajan, Sreenath, and

Kulkarni (NIDCR), DHHS Reference No.

E–150–00/0, Licensing Contact: John

Rambosek, Ph.D.; 301/496–7056; e-mail:

rambosej@od.nih.gov.

This technology describes transgenic

mice that selectively overexpress

transforming growth factor beta-1 (TGFbeta1) in odontoblast and ameloblast

cells of teeth. Ameloblasts mainly make

enamel, whereas odontoblasts make

dentin. These transgenic mice mimic

dental symptoms similar to those seen

in common tooth disorders such as

dentin dysplasia and dentinogenesis

imperfecta. Both of these human dentin

defects are inherited in an autosomal

dominant manner and appear to be

caused by abnormal dentin production

by odontoblasts and associated poor

mineralization of the dentin matrix. In

both diseases, teeth are discolored and

fractured, causing difficulties in eating

food. Experimentally, these mice

display discolored and fractured teeth

with defective dentin. This transgenic

mice model will be valuable to advance

our understanding of the molecular

pathogenesis underlying dentin

dysplasia and dentinogenesis imperfecta

and also for developing therapeutic

strategies.

This material is available for licensing

through a PHS Biological Materials

License.

Dated: November 13, 2000.

Jack Spiegel,

Director, Division of Technology Development

and Transfer, Office of Technology Transfer,

National Institutes of Health.

[FR Doc. 00–29716 Filed 11–20–00; 8:45 am]

BILLING CODE 4140–01–P

DEPARTMENT OF HEALTH AND

HUMAN SERVICES

National Institutes of Health

Government-Owned Inventions;

Availability For Licensing

AGENCY: National Institutes of Health,

Public Health Service, DHHS.

ACTION: Notice.

SUMMARY: The inventions listed below

are owned by agencies of the U.S.

Government and are available for

licensing in the U.S. in accordance with

35 U.S.C. 207 to achieve expeditious

commercialization of results of

federally-funded research and

development. Foreign patent

applications are filed on selected

inventions to extend market coverage

for companies and may also be available

for licensing.

ADDRESSES: Licensing information and

copies of the U.S. patent applications

listed below may be obtained by

contacting Dale Berkley, Ph.D., J.D., at

the Office of Technology Transfer,

National Institutes of Health, 6011

Executive Boulevard, Suite 325,

Rockville, Maryland 20852–3804;

telephone: 301/496–7735 ext. 223; fax:

301/402–0220; e-mail:

berkleyd@od.nih.gov. A signed

Confidential Disclosure Agreement will

be required to receive copies of the

patent applications.

Automated Core Biopsy Instrument

Erik Kass, Carter Vanwaes (NIDCD),

DHHS Reference No. E–269–00/0 filed

20 Sep 2000.

The invention is an automated core

biopsy instrument that may be operated

with one hand. The instrument has a

single activation element that causes a

stylet to advance into the tissue of

interest as a cutting cannula disposed

around the stylet is fired to shear off the

tissue into specimen notches disposed

in the stylet. The invention is

constructed so that the stylet and

cutting cannula may be separately

driven and biased. The cocking

mechanism of the automated core

biopsy instrument is used to cock both

the stylet assembly and cutting cannula

assemblies against separate biasing

springs. Manipulation of the cocking

mechanism permits the exposure of

tissue in the specimen notches when

desired. The instrument has a locking

mechanism that is used to prevent

inadvertent firing of the automated core

biopsy instrument.

EZ Navigator and EZ Forms Software

Andrew Schwartz, William K. Jones,

Michelle R. Ugas, Ta-Jen Hu (CIT),

DHHS Reference No. E–236–00/0.

The EZStart invention is a method of

accessing a database management

system that can be used to convert nonrelational data to relational data and

create and manage relational data over

a network such as the Internet. The

invention provides user-friendly access

to data stored in a database management

system, allowing users with little or no

knowledge of database management

systems to access, store and manage

data using only a web browser. EZStart

provides a generic platform from which

any user can select, insert, update and

delete data without creating a custom

software application for each user. The

invention automatically generates

navigation and data forms, allowing

access to a Relational Database

Management System (RDBMS) while

masking the complexity of the RDBMS.

Using a function of EZStart coined

EZNavigator, users can easily maneuver

through the RDBMS, view lists of

objects, drill-down into column, view

and index definitions, and manage

object privileges. A separate function of

EZStart, known as EZForms, allows a

user to select, insert, update and delete

rows in tables. No Structured Query

Language (SQL) knowledge is required

to perform these functions, but

advanced users can use EZForms to

generate SQL into a text area for

modification and execution of the SQL.

The SQL can be saved into and retrieved

from a repository.

Integrated Low Field MRI/RF EPRI for

Co-Registering Imaging of In Vivo

Physiology and Anatomy in Living

Objects

Murali K. Cherukuri et al. (NCI),

DHHS Reference No. E–120–99/0 filed

01 Nov 1999.

Obtaining physiological information

in a non-invasive manner from living

tissue will provide valuable

information, rather than invasive

methods that are sometimes not

available and also may damage living

tissue. EPRI (Electron Paramagnetic

Resonance Imaging) is the technique to

investigate physiological information

such as oxygen imaging and

Federal Register / Vol. 65, No. 225 / Tuesday, November 21, 2000 / Notices 69951

pharmacokinetic imaging in a noninvasive manner after non-toxic

infusion of the spin probe.

However, the disadvantage of EPRI is

the lack of proper orientation of the

physiological image with respect to

anatomy. On the contrary, Magnetic

Resonance Imaging (MRI) methods are

excellent for providing images with fine

anatomical detail, but are often not

possible methods that provide

physiological information co-registered

with anatomy with clinically relevant

resolution.

The current invention complements a

MRI with EPRI methods to solve each

method’s problem described above. A

low-field MRI(5–30 mT) module is

integrated into an EPRI(5—20 mT)

system to provide an MRI scout image

to properly orient the EPRI

physiological information with respect

to anatomy (A common magnet/gradient

coil assembly is used for both MRI and

EPRI scans).

Therefore, the EPR images contain

spectral information regarding the local

physiological conditions such as oxygen

status. This data, when overlaid with

anatomical images of MRI (Magnetic

Resonance Imaging), co-register

anatomical MR images and EPR

physiological images.

Dated: November 13, 2000.

Jack Spiegel,

Director, Division of Technology Development

and Transfer, Office of Technology Transfer,

National Institutes of Health.

[FR Doc. 00–29717 Filed 11–20–00; 8:45 am]

BILLING CODE 4140–01–P

DEPARTMENT OF HEALTH AND

HUMAN SERVICES

National Institutes of Health

National Institutes of Health Guidelines

for Research Using Human Pluripotent

Stem Cells; Correction

ACTION: Notice; correction.

SUMMARY: The National Institutes of

Health published in the Federal

Register on August 25, 2000, the final

National Institutes of Health Guidelines

for Research Using Human Pluripotent

Stem Cells (65 FR 51976). The final

Guidelines contained incorrect citations

and other errors. The final Guidelines,

with the corrections made in this notice,

are available on the NIH stem cell

information web site at:(http://

www.nih.gov/news/stemcell/index.htm).

For additional information on human

pluripotent stem cells, refer to this web

site.

FOR FURTHER INFORMATION CONTACT: NIH

Office of Science Policy, Attention:

HPSCRG, Building 1, Room 218, MSC

0166, 9000 Rockville Pike, Bethesda,

MD 20892, (301) 594–7741 or e-mail

stemcell@mail.nih.gov.

Corrections

1. In Section II.A.2.d of the Guidelines

(65 FR 51980, first column), change

‘‘human pluripotent stem cells,’’ at the

end of the section, to ‘‘embryo.’’

2. In Section II.B.1.a. of the

Guidelines (65 FR 51980, second

column), change ‘‘Section II.A.2’’ to

‘‘Section II.B.2.’’

3. In Section II.B.2.a. of the

Guidelines (65 FR 51980, third column),

add the following at the end of the

section: ‘‘and with 42 U.S.C. § 289g–

2(b).’’

4. In Section IV.B. of the Guidelines

(65 FR 51981, first column), change

‘‘applications shall’’ in the first sentence

to ‘‘documentation of compliance with

the Guidelines will’’ and insert after ‘‘by

HPSCRG and’’ the words, ‘‘all

applications will be reviewed’’.

Dated: November 15, 2000.

Ruth L. Kirschstein,

Principal Deputy Director, NIH.

[FR Doc. 00–29791 Filed 11–20–00; 8:45 am]

BILLING CODE 4140–01–M

DEPARTMENT OF HOUSING AND

URBAN DEVELOPMENT

[Docket No. FR–4565–N–31]

Notice of Proposed Information

Collection: Comment Request; Section

203(k) Rehabilitation Mortgage

Insurance Program

AGENCY: Office of the Assistant

Secretary for Housing, HUD.

ACTION: Notice.

SUMMARY: The proposed information

collection requirement described below

will be submitted to the Office of

Management and Budget (OMB) for

review, as required by the Paperwork

Reduction Act. The Department is

soliciting public comments on the

subject proposal.

DATES: Comments Due Date: January 22,

2000.

ADDRESSES: Interested persons are

invited to submit comments regarding

this proposal. Comments should refer to

the proposal by name and/or OMB

Control Number and should be sent to:

Wayne Eddins, Reports Management

Officer, Department of Housing and

Urban Development, 451 7th Street, SW,

L’Enfant Plaza Building, Room 8001,

Washington, DC 20410.

FOR FURTHER INFORMATION CONTACT:

Vance T. Morris, Director, Office of

Single Family Program Development,

Department of Housing and Urban

Development, 451 7th Street SW,

Washington, DC 20410, telephone (202)

708–2121 (this is not a toll free number)

for copies of the proposed forms and

other available information.

SUPPLEMENTARY INFORMATION: The

Department is submitting the proposed

information collection to OMB for

review, as required by the Paperwork

Reduction Act of 1995 (44 U.S.C.

Chapter 35, as amended).

This notice is soliciting comments

from members of the public and affected

agencies concerning the proposed

collection of information to: (1) Evaluate

whether the proposed collection is

necessary for the proper performance of

the functions of the agency, including

whether the information will have

practical utility; (2) Evaluate the

accuracy of the agency’s estimate of the

burden of the proposed collection of

information; (3) Enhance the quality,

utility, and clarity of the information to

be collected; and (4) Minimize the

burden of the collection of information

on those who are to respond; including

the use of appropriate automated

collection techniques or other forms of

information technology, e.g., permitting

electronic submission of responses.

This Notice also lists the following

information:

Title of Proposal: 203(k)

Rehabilitation Mortgage Insurance.

OMB Control Number, if applicable:

2502–0527.

Description of the need for the

information and proposed use: This

request for OMB review involves a

reinstatement of a previously approved

information collection for 203(k)

Rehabilitation Mortgage insurance

(OMB control number 2502–0527) that

expired on October 31, 2000. The

information collection implements

recommendations to mitigate program

abuses that were cited in an Audit

Report of HUD’s Office of Inspector

General. The information collection

focuses on the loan origination process

and requires (1) certifications and

disclosures concerning identity–of–

interest borrowers and program

participants, and (2) proficiency testing

of home inspectors/consultants.

Periodic reporting of the collected

information is not required.

Agency form numbers, if applicable:

HUD–92700 & HUD–9746–A.

Estimation of the total numbers of

hours needed to prepare the information

collection including number of

respondents, frequency of response, and