111111111111111111111111111111111111111111111111111111111111 

# • OTS0200488 OneSource. OneSearch. OneSolution. 

# USEPA STATUS REPORT: HEXABROMOCYCLODODECANE WITH ATTACHMENTS

21 JUN 1978

oowntoadin9···



# - U.S. DepartmentofCommerce 

### NationalTechnical InformationService

# OneSource. OneSearch.OneSolution.

Providing Permanent, EasyAccess to

# u.s. Government Information



## The NationalTechnical InformationService isthe Nation's largestrepositoryanddisseminatorof government-initiated scientific,technical, engineering, and related business information.The NTIScollection includesalmost3million information products ina varietyofformats: electronicdownload, online access, DVD, CD-ROM, magnetictape, diskette, multimedia, microficheand paper. Search the NTIS Database from 1990 forward More than 600,000 government research information products have been added to the NTIS collection since 1990. All bibliographic entries for those products are searchable on the NTIS Web site at www.ntis..gov. Download Publications (1997 • Present) NTIS provides the full text of many reports received since 1997 as downloadable PDF files. When an agency stops maintaining areport on its Web site, NTIS still offers adownloadable version. There is afee for each download of most publications. 

### Formore informationvisitourwebsite: 

# www.ntis.gov

**~;/"\.** U.S DEPARTMENTOFCOMMERCE 

# .l!J' .TechnologyAdministration \ • · / NationalTechnical InformationService
.......,.,. Springfield,VA 22161

### COOING FORM FORSRCINDEXING REVISED10115/66

ACLITE INHALATION TOXICITY STUDY IN RATS WlTH HEXABROMOCYCLODODECANE WITH ATTACHMENTS AND COVER LETTER DATED 042478

HEXABROMOCYCLODDDECANEVELEIICCI!.,. CHEMICAL CClAPI:IIRATIDI\I sa1 EAST OHIOSTREET • CHICAGO. lt.UNCI6 60611 • 312•670u4fiOO

Director of the Office of Toxio Substances (WH-·557) u.s. Environmental Protection Agency 401 MStreet, s.w. Washington, D.C. 20460 April 24, 1978

Re: Firemaster 100, trade name for hexabrorr.ocyclododecane, CAS 

### No.. 11:3194-55-61 Dear Sir: The attached document is submitted for your files and in compliance with TSCA section 8(e) if the latter is necessary. In summary, the document reports the results of a laboratory toxicology study. For the record, the document is identified as follows: "Acute Inhalation Toxicity study in Rats", IRDC #163-500, April 10, 1978. We make no judgment that this document contains information concerning a substantial risk. We reserve our right to contest the propriety of TSCA section 8 (e). ·

TRL:eh Enclosure Sincerely, VELSICOL CHEMICAL CORPORATION

# L~ue-o7 Manager, RegUlatory Activities Environmental sciences and Regulatory Activities

### •· 

# 8'8-1'6 DO 

## I



# ~7 InternationalResearchandDevelopmentCorporation

SPONSOR: COHPOUND: SUBJECT: Velsicol Chemical Corporation FM 100 Residue Acute Inhalation Toxicity 5tudy in Rats.

Basil

**K~** J

**~,.Leong**, .D. Director of Inhalation Toxicology

Approved by: D, Clifford Jessup, Ph.D,'" . . . . .· . -



### -·~:-:-:



### ~~.-..**~-** .....,:::.



### ~**:=~-~-~'i~.;.!\R_~~~':.,~tt-F,~:;D?:;:17~-~£lr.:-·of:;:·~~s~;c1l-~-**..

### ==

**·.----~- -=-~-~~=--·:~** **;·:;;-~~::,-;;~;~;._;:-~:**

## _::..:_

**-~_-;:~:;:.~~=;-~~ ;~;;;.** 

Date: April 10, 1978

153:..soo

# ·. InternationalResearch

# andDevelopmentCorpor:_ation

,, ....Page 1 I. SYNOPSIS Inhalation exposure of rats for 4 hours to a vapor and aerosol aemosphere of FM 100 Residue, at a calculated

**concentra~ion** of

**22~9** mg/1, resulted in dyspnea, salivation,

**lacr~tion,** nasal discharge, eye squint and body weight loss. One female rat died on day 3 of the postexpasure period. Necropsy of the dead female rat revealed dried blood aroUnd the nares, patchy red areas on the lungs, and an air distended stomach filled withyellow liquid. The remaining 9 rats recovered by day 14 of the postexpoSure period.

163-500

## InternationalResearchandDevelopmentCorporation Page 2 II. COMPOUND The compound was received from the V.elsicol Chemical Co:z:poration, Chicago, Illinois on .Tuly 12, 1977. It yas received and identified as follows: Compound Identification FM 100 Residue Flammable liquid NOS ATT: C. Calo 113322 77.901

163-500 Desc:ript.ion brown liquid with off white residue at bottomc 

## InternationalResearchandDevelopmentCorporation

·."":" Page 3 III. PROCEDURE A. AlUMAL EXPOSURE: Five male and 5 female Charles River CD rats were used in the study of the compound. The ma,le rats weighed from

**200_ta_202._&!~L'ffi'l:. tl:l~**  females from 230 to 232 g1:ams. The 'f_ats we1:e housed ind:l:vidually in wire-mesh cages and were kept throughout the pre- and postexposure periods in a temperature and humidity controlled room in accordance with standards Outlined in the uGuide For the Care and Use of Laboratory Aoimals; DHEW No. (N.I.H. 74-2.3) 1974". Pudna Laboratory Chow and water

**wei~** supplied ad libitum except when the rats were in the expo- .\1
- sure chambe:c. During exposure, che rats uere caged individually in compartmented t.:ire-mesh exposure cages.. The cages were placed

**~i.** a 160-liter, cubical, stainless steel and glass chamber. A constant

**ch~ber** airflowwas main-



### -- tained by means of a rotary centrifugal air pump located at tha exhaust side of ehe chamber. The chamber exhaust was filtered with an activated charcoal filter and a Cambridge Absolute® filter before being discharged outside of the labol:atory. B. OBSERVATIONS:



### :-_::.;.::.:-::~~::~0bseP~<,L.t-:l.ons;:.fo.r**~-pharmaco**toxi:c''sigris :and·inO:rtality



### :we:r.e:·:n'lad.~.~.**d,p~_ing~?.~·~:.:**



## :=-;;;ci"-~~:;i.it-~;**foil~~g t~~--i"h~ui:**  **ex-po~ur~ ;er-ic~**  **a~~ d-,;-;iftii~~** **""~** 

# - "'--;::: after for 14 days. Individual body weights were recorded prior to the 4 hour exposure and periodically thereafter in order to detect any latent effects following the

**e.~osure.** All rats that died during the experimental period we1:e necropsied. The 1:ats which survive_d the experimental period were sacrificed and discarded. C. VAPOR ATMOSPHERE: The vapors and aerosols of the compound were generated by metering ® 'fhe liquid with a ft1I Lab Pump into a positive pressure atomizer located near the chamber air inlet, at the

**to~** of the 9xposure

**cha~be~~**

**~·;r'~** 163-500

## 1nternationalRese(lrchandDevelopmentCorporation Page 4 An air pressure of 10 psig, with an airflow rate of 8 1/min, was applied to the atomizer which aerosolized ths liqui.d for rapid vaporization" The vapors and aerosols emerging from the atomizer were diluted by the incoming chamber air at the rate of 12 l/min to the desired concentration. The **concentra~ion** of the compound (22.9 mg/1) in the chamber atmosphere was calculated from the ratio of the rates of liquid dissemination (458.3 mg/min, when the specific gravity of the compound was gravimetrically

**deter~** mined to be 1.2597) to the total chamber airflow (20 limin, the volume of air ejected from the atmoizer plus the

**vo~ume ~f**  make-up air).

163-500

# .. lnternationalResearchandDevelopmentCorporation Page 5 IV. RESULTS A. ANI!:IAL OBSERVATIONS: The immediate response of the rats to the exp_erimeri.tal: atmosphere was an increase of activity· in preening. After several minutes of ex**posure~** the rats began to settle

**down~** After 30minutes of exposure a few rats exhibited eye squint, slight dyspnea, salivation, lacrimation and nasal discharge. As the exposure continued more rats developed the aforementioned symptoms. The slight dyspneic condition changed to

**m~rk** ed dyspnea in some rats. After 4 hours of exposure all the rats exhibited eye

**squint~** Six rats had slight dyspnea while 4 rats were obserVed with marked

**dyspnea~** On day 1 postexposure, all rats exhibited a

**-s~ight** or a marked dyspneic

**condi~ion,** with one male rat exhibiting salivation. On days 2 and 3 postexpOsure, the dyspneic condition changed to gasping -in all male rats and 2 of the female rats. One fema1e rat died OiL day _3 postexposure and all of the remaining rats had a significant body weight loss. Following day 3 postexposure, all of the surviving rats appeared to begin to recover and gainweight. By the end of the

**~per** imental period, the 9 surviving rats appeared normal. The individual body weights of the rats recorded during the experimental period are

**':0:0~-==-.:.:':'~">:,:. c:·:o'tr~_s<i!:~~il:l.;,1_!;ib~e:** ·1; B. ··

### i-i6R.'fAI.iri·;' one female rat died on day 3 postexposure. C. GROSS NEcROPSY: Gross necropsy of the dead rat revealed dri"ed blood around the naies, patchy red areas on the lungs and an air distended stomach filled with yellow liquid.

163-500' _":::= FH 100 Residue: TABLE 1. Calculated

Concentration. Rat

Number 22.9 mg/1' 77882

77883

77884 77885

77886 17887

77888 77889 77890

77891 163-500 Sex M l:l.'

·k H H F

F

F F F **{~,** .. , I ·!; L, ,, II H,IH·

'\'I' **A~~~e** Inhalation Toxicity Study in Rats.

' '

J:;.j) Individual Dody Weights, Grams.

. ' ' : **~ q-~n-** 

/ .l!; PreexpoSUre 0 ';jl'

**J.~** i I

'Fi'l' ... .... \ Li !, zo'o•' **i~~li'** 2 **~.** : .w,: **1~~.** :13o! 2;)01'

232!'

2:1dl 2J9!• ':;":. .,. 'I.

**~ !~1**  **~** ; " .

... I !:;!' I\! ."I:· ::,::, ..

t:·,· ·!;• 1('5, '''Ti **!··;~(** i.l.'l'i; I_::) !I·Hi ,!:Jiff ;;.q·v

l :'f;l: .. ::! 9 ; !':·,, I i !• 'I I 1-

1 I;· 2 160 150

164

154

159 .. 204

214

Died 200

210 _.,,·f

'.l.

.-,_.c **·Pastexpo~ur~** (pays)

4. 6 164

153

182

163 163 196

220 217 220 ,?--....--

(! ._,

·:":-_ \\ **'--~.** ·. c {l.

·,\ II\ **·~**

**_,.,__:;.~,:.:::::-:::** .-:;;,_':'_)· 185 170

190 .. 180 184 210

22# 223 223 13 230

218

253 236

210 232

231 245

236 **.~~** ,, "' **~** 'l1l "'UNITED STATE? ENVIRONMENi"AL PROTECTION AGE\'lCY WASHINGTON.

### o.c,' '20460 :.,.;::.·• ·

.' 

### APR 2 71978



# ..

**--~** Mr. 

### Thomas R. Loy

**Manag~r, R~gulatory**  

### Activities Velsicol Chemical Corporation 341 East Oh.io Street · Chicago, Illinois 60611 Dear Mr. 

### Loy: :':

**~·**'=' -,

**~** 

### ........

**·~-** ·.:

**-~.:**·- ;,.

**·P.Fl3':~C?.E**OFTOXIC

**SU~ANCES** .

: ','•! ' •·



# .. This W:ill acknowledge receipt'



### ~f your letters of various dates transmitting data to EPA under Section B(e) 

### • of the Toxic Substances Control Act. For your information, your submissions have been assigned document control numbers which are listed on the attached sheet. Any future

**corres~** 

### pondence regarding these notices should reference the perti- ·· nent document control number and .be directed to the OTS Document Control Officer, Chemical .Information Division, Office of Toxic Substances (TS-793), Environmental Protection Agenc"y, Washington,·D.c.· 20460.

**Sincerely~** 

# i · ... l '!' . ',, 

### Joan Urquhart . OTS Document control officer, ·-:.':.: ,:_·:··:. ' .: :;



### . .. )'

**~**



### Attachmsmt ··::

### --

### 4/17/78 . 4/17/78 4/.17/78 4/lB/78

**4/24/7~** 

### 4/24/78 

### Submission:' letter and OSHA/ NIOSH correspon- dence (Tris) · letter and memo (undetermined cause) letter and study ·(FM BP4-A)

.

# .. 

### FM 100 

### letter and memo :.:··-:·: " 

### · 1Jocumen·t·Cont·rol Number



# .. SEHQ-0478-0129

SEHQ-0478-0136. SEHQ-0478-0137 

### 8EHQ-0478-0l38P



### ..

### CODING FORMFORSRCINDEXING REVISED10/15186

OTS0200488..

USEPA STATUS REPORT: HEXABROMOCYCLDDODECANE WITH ATTACHMENTS

HEXABROMOCYCLODODECANE

### UNITED

### STATES


### ENVIRONME~TALfiROTECTION

## AGi:«CY DATeo June 21, 1978 (Revised May 10, 1979) SUOJeCTo StatusReport llEJiQ-0478-0137 **Approved'---'-~--**
PROUr Joseph J. Merenda,. Acting Director AssessmentDivision, OTE/OTS (TS-792) Revision Needed
TOr Warren R. Muir, Deputy Assistant Administrator for Testing and Evaluation, OTE/OTS (TS-792) Submission Description Acute inhalation toxicity of FM 100 (hexabromocyclododecane) inrats. Submission Evaluation The weakness of. this study is that itwas not done on F.M 100 but an a residue which contains a ilammable liquid (FM 100 presumablyhas low flammability; therefore,

**so~** other materialmust also be present). Iu this instance, the absence of controls is not of as great a concern

**t~** as the fact that the animals showed dyspnea. This couldbe dtie either to reflex nervous sytem effects or to direct irritant effects on the tracheobronchial tree and/or the lungs. The squinting suggests that there was considerable irritation. The fac:t that effer:ts"'·persisted beyond the exposure period and that there was considerable loss inbody weight suggests that there was pulmonary damage. The dry blood seen around the nose and in the

**passage~ay** of the 'lungs

**at'·~·.arit:opsy** suggestS that irritant injury had occurred. The most important point at this ti.me concerns an aclequate analytical characterization of the test compotmd. Current Production and Use Hexabromocyclododecane (Hl!CD) is listed :!.n the Directory of Chemical Producers; thus indicating that it is produced in commercial quantities·(>1;000 lb/yr}. HBCD is used as a fire retardant in copolymers of styrene with acrylonitrile, N-vinylpyrrolidlne, divinylbenzene, methylacrylate, poly (methyl methacrylate}, or polyethyl.ene. It is also·used as·a fire retardant inmolded and foamed thermoplastic polystyrenes and in polypropylene- based molding compositions. When incorpOrated into these plastics. HBCD · imparts a self-extinguishing property to

**th~** material.

NOTE: This status report is the result of.a preliminary.staff'



## e~'\l~t:ian of information submitted to EPAunder Section l!(e)_ of_TSCA; · .·. ';,, Statements made herein

## are not to be

**r~garded as,,.express~lll:i'>,**  finsl Agency poUcy or intent.with ,respect ·to·this··partii':uliiri,. chemical. Any re_view of dui·.status· repor:t

### .·shQti.ia· 

### tak:e·:.:tii'tO:t.·,·· '· consideration the fact that :It inaybe

**•lias~cL**on"!i'tieO!t>Plet'!'

### )\>: infotmation. · · .... ·· ·c -

**····-~** • ··.· ·· •·.
**•;,;~·t:''** ·"·· EPA FCA..,_ UZO..& IREV. So7Gl ,214
. ,_ **.',>~:'·\)-** 

## ,,;,·,;;:·:

**·,·-t.i~.:.z.'.** '

### .· .. . .. -

**~.** ;.·;: ',.-
-HBCD is also used

## in the production of adhesives used for cementing

**(lu~ing)** polystyrene foam sheets. This use arises from its ability to reduce the molding time necessary for cellular polystyrene particles to form into a compact foam block•

.

# , Comments/Recommendations Several other subtnissionshave been received

**6~'FM** 100 (BEHQ-0278'-0051; SHBQ-0278-0065; SEHQ-0278-0088). The chetnicaltdllbe evaluated as pari: of the Assessment Division's ongoing study of flame retardaUt teChnology. FM 100 may be an environmentally persistent compound. (a) This submission, like others, was deficient in a number of areas. The notifier shouldbe asked to provide adequate analytical data on the composition of the Ddxture. tested, gLoss fin'dings On death, clinical observations, and physical-chetnical data on the test substance. (b) This submission shouldbe referred to NIOSH and OSHA. (c) The submitter shouldbe asked to.support his contention tbat the information presented in this submission reasonably supports a conclusion of substantial risk.

'';.·· ·.: 215 .'

## .. ,;.'.UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, P.C. 20460

Mr. 

### Thomas R. Loy Manager, Regulatory Activities Velsicol Chemical Corporation 341 East Ohio Street Chicago, Illinois 60611 Dear Mr. 

### Loy: 

# ~I
OFFICEOF' TOXICSUBSTANCES



### The Office of

**To~ic** 

### Substances has performed preliminary evaluations of your submissions (identified in Attachment I) under section S(e) of the

**To~ic** 

### Substances Control Act (PL 94-469). The enclosed status reports are the results of those evaluations; however, these reports do not necessarily represent EPA's final conclusions on these submissions. Submission of the information contained in the notices listed in Attachment I does not appear to be required under section B(e) of the Toxic Substances Control Act. Please refer to the March 16, 1978 Federal Register publication entitled "Statement of Interpretation and Enforcement Policy; Notification of Substantial Risk" (43 FR 11110) for guidance as to the types of information which shouldbe submitted.·under section B(e). If, after rev.iewing the policy statement and reconsidering the information contained in these,notices,·you conclude that any or all of the

**submiss~ons** 

### listed in Attachment I are appropriate B(e) submis¢icns, please respond to the information requests

**pert~~ning** 

### to those submissions. These information requests can 

### 5e found on the attachment entitled nRequests for Further Information." In cases where you conclude .in retrospect that an earlier submission is not appropriate under section B(e), please notify EPA of that decision. In responding to the nRequests for Further **Information,~** 

### or in otherwise communicating with EPA regarding a previous submission under section B(e), please refer to the EPA Document Control Number assigned to that submission. If further information is to be provided on more than one 8(e)2 

### . .:; 

### submission, please use separate sheets for each. 

### As in the case of initial S(e) submissions, all responses will be. placed in the public file unless conficientiali.ty is <:::laimed according to the procedures outlined in Section Xof the March 16, 1978 policy statement. Any confidentiality claims should be supported by submission of information as described in the enclosed item titled' "Support Information for Confidentiality Claims." Responses to the "Requests for further Information" should be received by the Docwnent

**Cont~:ol** 

### Officer within 45 working days of the date of this letter.

Enclosures 

### J. Merenda rector ment Division

### Subject chemical(s): Date submitted: 

### EPA Document Control No.: Subjectchemical(s): Date submitted: 

### EPA Document Control No;: Subjectchemical{s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA 

### Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s):

...

tiate submitted: 

### EPA Document Control No.: 

### ·._,

**S~&bject** 

### chemical(s}: ":: Date submitted: EPA·Document Contra1No.: Subject chemica1(s): Date submitted: EPA Document Control No.: Subject chemical{s): Date submitted: EPA Document Control No.: Subjectchemical(s): Date submitted: EPA Document Control No.: Attachment I ,::>ft.tJt'. ':'/

**·:~**

## ....

# ,
PCL bottoms, hex PCL bottoms 9/23/7'7 . BEHQ-0977-0004 

### dibromoethy1 acetate "fi/23/77 BEHQ-0977-0005 

### dicyclopentadiene acrylate 11/7{77 BEHQ·1177-0017P 

### benzoic acid ll/7/77 

### BEHQ-1177-00lBP unknown l/13/78 

### BEHQ-0178-0031P 

### rnethy1amino acetaldehyde dirnethylacetal 3/21/77 BEHQ-0178-0036 

### polypropylene glycol 2/9/77 BEHQ-0178-0041 

### Polyvel M-106 polymer 9/26/77 BEHQ-0278-0050 FM-100 

### 9/26(77 BEHQ-0278-0051 

### chlorendic anhydride
,,/30/77 

### BEHQ-0278-0058 chlorendic anhydride 11/30/77 

### BEHQ-027!1-0059 MC-948 12/2/77 BEHQ·!IZ78-0060

### Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemica1(s): Date submitted: EPA Document Control No.: Subject chsmica1(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subjeci chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Da;te submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s):

..... Date submitted: EPA

**O~~ijment** 

### Control No.: '

**~tibject** 

### chemica1(s): · :. Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: methendic anhydride, maleic anhydride: 12/16/77 .. 8EHQ-0278-0053 •.' hexabromocyclododecane (FM-1OO) 12/19/77
. 8EHQ·0278-0065

**VC-935~** 

### 12/9/77 BEHQ-0278-0066 diisopropylamino ethyl chloride hydrochlo1 1/11/78 

### 8EHQ-0278-0067P 2,3-dibromopropan.ol ·· 1/19/78 "'" BEHQ·D278-0068 HCS-3510 2/15/78 

### BEHQ-0278-0072 CN-110-109 2/17/78

**8EH~0278-0074** 

### unknown 2/7/78 8EHQ·0278-0075P phosgene 2/7/78 

### 8EHQ-0278-0076P dicyclopentadiene, dicyc1opentadiene a1col 2/8/78 8EHQ·0278-0077P phosphorus ox_ychloride 2/B/78
. 

### 8EHQ-0278-0078P phosgene, toluene 2/8/78 BEHQ-0278-0079P

'·: ·'·Subject chemical{s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA

**Doc~ment** Contt·ol No.: ::·. phosphorus exychloride 2/10/78 BEHQ-0278-0080P unknown 2/17/78

**~** 8EHQ-0278-0081P



### ~ Subject chamical(s): dioxins Da

### t<i'lfiiBDil."fteo!:,__ 3/l/78 EPA Docul!ient·control No.:

### ----,_,cllEilQ-0378-0085 Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject:chemical(s}: Da_'te submitted: EPA

**Docum~t** Control No.: 

### ""

**Su~fect** chemical(s): :-· Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s}: Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: **Fir~qster** 6BO 3/l/7ff',_. -?y-=-'
**BEHQ-037a.::coeo-:=-::--="'""'"·--:·~--** \. 

### \I isocyanate

**dime~** of **5-t-butyl-l,3,4-tKiadazol-2~yl** 3/1/78 

### t BEHQ-0378-0087

**~-** residue from hexabromoeyclododecane 3/l/78 BEHQ-0378-0088 chlorinated norbornene derivative 3/l/78 8EHQ-0378-0089 VCC-935A 3/1/78 BEHQ-0378-0090 MC-993 3/l/78 8EHQ-0378-0091 VC-948 3/1/78 8EHQ-Q378-0092 chlordene epoxide 3/l/78 BEHQ-0378-0093 chlorendic anhydride 3/6/78 BERQ-0378-0094 tribromopbenol 3/6/78 SEHQ-0378:-0095Subject chemical(s): Date submitt.ed: EPA DoCume·nt Control No.: Subject chemicai(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.:

**su~ject** chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No,: Subject chemica1(s): Date submitted: EPA Document Control No.: ·subjec.t chemical(s): Da:i:e submitted: EPA
**Docum~t** Control No.: '•t, Subject chemical(s): -· Date submitted: EPA
**Doc~ent** Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical{s): Date submitted: EPA Document Controi No.: 4 dicyclopentadiene 3/7/78
. . 8EHQ-03iB-0097 :; VC··948 3/7/78 BEHQ-0378-0098 MC-984 3/16/78 BEHQ-0378-0100 chlorendic anhydride 3/16/78 8EHQ-0378-0101 VCC-935A 3/16/78 8EHQ-0378-0103 MC-984 3/27/78 8EHQ-0378-0107 methanol 3/27/78



### 8EHQ-0378-0l08,~ hydroxyaceta1debyde dimethyl acetal 3/27/78 8EHQ-0378-0lll benzene .3/27/78 8EHQ-0378-0112 methyl acetate 3/27/78 BEHQ-0378-0114 FH-680 3/31/78 BEHQ'-0478-0115 :·



### .. :.. :::.Subject chemical(s): Date submirted: EPA Document Control

**No~:** Subject chemica.l(s): Date sul.,mi.tted; EPA Document Control No.: ,.Subject chemical(s): Date subtnitted: EPA Document ControlNo.: Subject chemical(s): Date submitted: EPA Document Control Non: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted; EPA Document Control No.: Subject cbemical(s): Date submitted: EPA Docum8nt Con;rol No.:



### Subjec~ 'l'hemic:al(s): !)ate submi1:ted: EPA Document:ControlNo.: ,,

# ..,

'
**Subj~ct** chemical(s):

· :. Date submitted: EPA DocUment Control No.: Subject chemic:al(s): Date submitted: EPA Document Control No.: Subject chemical(i): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: 5 tetrabromobisphenolA, PNA's 3/31/78 8EHQ-0478-0U6 PNA's 3/31./78 BEHQ-047 8-0117 unknotm. 3/31/78 SEHQ-0478•0118
**~rcmoacetaldehyde** dimethyl acetal 3/31/78 8EHQ-0478-0ll9 sodium acet.ate 3/31/78 BEI!Q-0478··0120 dibromoethyl acetate 3/31/78 8£HQ-0478-0l21

**PHT~4** 3/31/78, 8EHQ-047B·Ol22 vinyl acetate 3/31178 8EHQ-0478-0l24 sodium bromide 3/31/78 8EI!Q-047B··Ol25
**bromoacetald,~hyde** solution 3/31/78
. BEHQ-0478-0126 chlorendic anhydride 3/31/78 **8El!Q~0478-0127** tetrabromobisphenolA (FM BP4-A) 4/17/78 BEI!Q-0478-0llO i

3-bromo-2,2-dimethylpropyl-2-chioroetbyl-2-

bromoethyl phosphate 4/17/78
. 8EllQ-04711-0l3l

'::. ' ' .:·:·. 

### ;:Subject chemfcal(s): Date s;Jbmi·tted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.:

**S~bject** chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document,Coni:rol No.:. subject.chemical(s): lfl;ite submitted: EPA Docum(nt Control No.: .f;· SuMect chemical(s):

·· Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: .; 6 MC 935,\. 4/17/78 BEHQ-04

**78~0J.3Z** vc 984 4/18/78. 8EHQ-0478-0i:l6 FM 100 4/24/78

**~** 8EHQ-0478-0l37V DCPD, .DCPD alcohol, benzyl chlodde 4/24/78 8EHQ··0478-0138P VC 935A 5/l/78 BEHQ-0578-0141 FMBP4A 5/1/78 8EHQ-0578-0l42 l-propano1monoester of tetrabromophthalate 5/1/78 SEHQ-,:0578-0143 CN-110-356 5/1/78 8EHQ-0578-0144 vc 948 5/1/78 BEHQ-0578-01.45 FMPH'l't 6/5178 8EHQ-067B-0171 VEL 4441 6/2/78 BEHQ-0678-0172 MC 984 6/2/78 SEHQ-0678-0173 CN 010-073 6/2/78 BEHQ-0678-0174Subject chemical(s): Dat:e submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date

**submitted~** EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document COntrol No.: Subject chemical(s): Date submitted: EPA Document ControlNo.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject.'chemical(s): Date submitted: EPA Document·:"ControlNo.: 

# ., ..' Su9ject chemical(s):

.:: Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control

**~o~:** Subject: chemical(s): Date submitted: EPA Document Control No.: Subject: chemical(s): Date submitted: EPA Document ControlNo.: 7 CN 110-335 6/2/78 BEHQ-0678-0175 VEL 4083 6/5/78 8EiiQ-0678-0176 DM!C 6/2/78 8EHQ-0678-0l7? 2-bromo-1,1-dimethoxyethane 6/6/78 8EHQ-0678-0179 dicyclopentediene, benzoyl

**chlorid~** 6/2/78 8EHQ-0678-0l80 dipropylene glycol dibenzoate 6/l/78 . BEHQ-0678-0181. unknown 6/6/78 8EHQ-0678-0l82PS 2,3-dibromopropanol, FMPiiT4 diol 6/9/78 BEHQ-0678-0187 MC-948 6/14/78 8EHQ-0678-0l88 VC-984 6/14/78 8EHQ-0678-0l90 VC 935A 6/14/78 BEHQ-0678-0191 VEL 3838 6/19/78 8EHQ-0678-0193 

### VEL 4038 6/19/78 8EHQ-067B-0194Subject chemica.l(s): Date submitted: EPA Document Control

**No.~** Subj.rct chemical(s): Date subrilitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject cbemi.cal(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Documerit.Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): · Date submitted: EPA Document,Con"trol No.: Subject;··chemical(s): ·· ·i>ate submitted: EPA Docum€ntControl No,: 

### ... ·<, Su6ject chemical(s):

·· Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.•: Subject chemical(s): Date submitted: EPA Document Control No.: 8 VEL 4609 6/19/78 8EHQ-0678-0l95 VEL 4578 6/19/78 BEHQ-0678-0196 VEL 3510 6/14/78 BEHQ-0678..:0197 VEL 3947 6/19/78 BEHQ-0678'-0199 dibr:omo··o-·dichlor:obenzene 6/19/78 8EHQ-0678-0200 methyl-m-chlorobenzoate 6/19/78 8EHQ-0678-0201 VEL 4411 6/23/78 8EHQ-0678-0203 PCS 1375 6/23/78

**8EHQ~0678-0204** Polvvel G 100 6/23/78 BEHQ-0678-020,5 Cblorendic anhvdride 6/15/78 BEHQ-0678-0206 dicvc1opentadiene acrvlate 6/23/78 . BEHQ-0678-0207 VEL 4582 6/15/78 8EHQ-0778-0210

**bromodichloroben~ene** (ne.itral oils frem hydi:phsi 7/20/78 BEHQ-0778-0220
;.·.•

:,• ..·;:. -. -

**~·** 

### ..
::Subject chemical(s): Date sub.,itted: EPA
**Docum~nt** ContrOl"'

### No.: Subject cbemical(s): na·te submitted: £PA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Sub;ect chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No,: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document,Control No.·: Subject:'chemical(s): 'Date submitted: EPA

**Doc~ent** Control No.:

**~f.** SuDject chemical(s): ' Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control.No.: Subject chemical(s): Date submitted: EPA Document Control No.: Subject chemical(s): Date submitted: EPA Document Control No,: 9 

### vc 948 7/20/78 BEHQ-0778-0221 DCPD alcohol 7/19/78 8EHQ-0778-0222 methyl-m-chlorobenzoate 7/19/78 BEHQ-0778-0223 VEL 4578 7/19/78 8EHQ-0778-0224 VEL 4441 7/19/78 8EHQ-0778-0225 metbyl-m-chlorobenzoate 7/19/78 8EHQ-077B-0226 tribromophenol,, sodium salt 7/19/78 8EHQ-0778-0227 ethylene dichloride 7/19/78 SEHQ-0778-0228 benzoflex S-552 7/19/78 8EHQ-0878-0229 chlorendic anhydride 7/31/78 8EHQ-0878-0231 ';,_· ..;0004 Request.s for :Further Information (Submissions identified by iast.four digits of Do9ument Control Number)

Please explain the terms "PCL.Bilttoins" and "Hex PCL Bottoms" used in the description of the test·material.
Please submit complete copi.es of the studies summarized in the submission and provide available data concerning the purit.y of the test material.
Please submit any additional information which is relevant to an analysis of the effects described in the your submission, e.g., copies of medical reports, corroborati've information from other employee complaints, relevant literature, etc.
Please submit a copy of thecompany doctor's report on this incident. If the employee's condit.ion was diagnosed by an allergist, as recommended in your submission, please inform'EPA of his findings. f.'
•• •f' :.;;''"- ..**~E** 

# •• Please provide any available information !'onc:erning PO!iJSible causative agent(s). ·::
Please provide solubility and volatility date on , methylamine acetaldehyde dimethyl acetal and brolt'.oaeet:.o·· aldehyde dimethyl acetal. · ·o·

:. : No additional information is requested at 

### this t;ime.

--.,·,, . 

### .•

. .-.No additional information is requested at this time. c. Please provide available analytical data on the com- positions of the mixtures tested (FH-100, Lot 53 and Residue of Lot 3322). Data on the physical/chemical properties of these substances would also be helpful. · · · Please provide information on physical and chemical properties of chlorendic anhydride which are relevant to an assessment of hazard to aquatic organisms•.Data on water solubility, rate of hydrolysis to chlorendic acid, pka of chlorendic acid, degradation of chlorendic anhydride and chlorendic acid are examples of the types of information which would be useful. 0059 The information on physical/chemical properties re- quested for submission 8EHQ-0278-00SB would also be useful for this submission.

**~Please** identify the testmaterial (MC 948) by a · sys.t'ematic chemical name and either a molecular formula or a

**Stfuctura~** formula•



## .. Please submit a copy of your safety data sheet on methendic anhydride and provide the results of any me.dical evaluation conducted on the exposed

**work~rs.** Please provide any available data concerning the ' physical/chemical properties of the test substance. Also,

·please report any pathological findings or clinical obser- ,·,/ations made on the test animals.. ·-3- 0066 Please provide the chemical structure of vc 

### S:35A. Information on the purity of the test material and its physical/chemical properties should also be.submitted. Is the test material identical to the commercial substance? If r1ot, please provide the information requested above for both substances. · Has Velsicol ever encountered or investigated a dioxin contamination problem with VC 935A? If so, please submit such informatin. 0067 Please submit a complete copy of the attending phy- sician's report. Please submit a full copy of the study from which the information in this submission was extracted. 0072 Please clarify the information concerning the method of dosing and the actual level which the rulimals received. 

### QQI!

**.~lease** clarify the composition of the mixture tested. Is

**~):!e** composition of CN-ll0-19 identical to·that listed for

**the~Fire** Master 680 oils? fr Please identify by systematic name the chemical(s} which caused the face, neck, and hip'burns when the C220 filter ruptured on December

**2~:.;"** 1977. · No additional information is requestep at this time. Please provide the structural foJ:"n\ula for dicylo.,, pentadien alcohol. A.l!i!O please provide.

**a~;.much** :j.nforma,. tion oh the incident reported,as you can, >:ncludl.ng

### -4- medical reports and follow-up activities. No additional information is requested at this time. No additional information is requested at this time. 0080 No additional information is requested at this time. 0081 Please identify the chemical agen(s) causing the complaints, if that information is

**~vailable.** 0085 No additional information is requested at this time. 0086 No further.information is requested at this time. Please provide information concerning the composition, purity, and physical/chemical properties of the test sub- stance.

**~ecause** of the text substance's potential for antichqlinesterase activity, you should submit any available

**inform<~.tion** which is relevant to an assessment of that potent,ial. Please submit a copy of p. 18 or the IROC re- por·l;,-·as it is missing from your original submission. 

### ooes'

**~** Please provide information concerning the composition and physical/chemical properties of the "FM 100 Residue" which was tested. Of particular interest in this regard is the amount of hexabromocyclododecan present in the residue. Available toxicity date on hexabromocyclododecane would be useful for correlation purposes. Please describe any gross patholical findings or clinical observation made on the.test animals. Also, please submit a copy of page 17 of the IRDC report (this page was missing from the report submitted to EPA).-5-


### No further information is requested at this tinie. 0090 

### No additional information is requested at this time. 0091 

### Please submit the result.s of any gross pathology or histopathology performed on the test animals. Please submit pages 17 and 19 of the "Acute Toxicity Studies in Rabbits and Rats", as these pages are missing from your original submission. 0092 

### Please submit a full copy of the report "VC-948, 77.1467; Acute Oral Toxicity Study in Mice: from the International Res!=arch and Development Corporation, 2-14-78, il63-514. Apage was missing from the report as submitted to this office. Also please identify the compound by chemical structure specify what the chemical is used for, and the amounts produced and used. Please answer the questions raised in .the Toxicological

**Evaluat~on** 

### section of the Status Report of the information is available. 

### ·.r 

### ...No further information is requested at this time. 0094 

### Because of the equivocal results obtained from the BALB/3T.3 mouse lymphoma assay, and the deficiencies in the oral LD. study, please consider repeating these tests, using experimental procedures discussed in tlle "submission evaluation" of the Status Report.-6- 0095 

### Please identify which tribromophenol isomer(s) was tested and provide any available data concerning the priority of the test substance. ,., Please inform EPA of any investigation of potential dioxin contamination of tribromophenol.

**Desc~ibe** 

### any quality control procedures which have been instituted to minimize dioxin contamination.


### No additional information is requested at this time. Please identify, by chemical structure, the chemical VC-948 (bis (tribromoneopentyl) pentaerythrito1 cyclic dyphosphate)• ·

0101
0103 

### ----::;No additional information is requested at this time. No additional information is 

### requested at this time. '' Please identify, by chemical structure, the chemical

**MC~935A** 

### (poly (dibromophenylene) oxide). 0107 

### Please provide available information concerning the composition, purity, and physical/chemical properties of the test material. Also, please clarify the dose data-Di.e. what was the concentration of active ingredient administered to the test animals? 0108 

### No additional information is requested-at this time,....•,.,.,___:-'::..,

.--..• o._,.. 0111 

### No additional information is requested at this time. 0112 

### No additional information is reguested at,this time. 0114 

### No additional in::>rmation is requested at this time. No additional information is requested at this time. 0116 

### Please submit a copy of the fish broaccumulation study mentioned in your submission as soon as the study is com- pleted. 0117 

### Please provide more information concerning the com"' position o; the raw materials C-9 and MPB. Also, please describe the chemical nature and use patteras of the resins made frQm these materials. 

# EPA should be informed of any subsequent developments in tl'i'is matter. OliB Please identify the abbrevia't:ed chemical names "DEBA" and "BADMA" by systematic chemical names and molecular formulas or structural formulas. Please clarify the relationship of the chemicals noted in BEHQ-0178-0036 and BEHQ-0178-0039 to theBADMA used in this study. Was the BADMA used in the dermal testing iden- tical to the lot used in this study? Is MAADMA known (or likely) to be contaminated with

**BAD~oA?**

## -a:.. 0120 No additional information is r.equested at this time. Please submit any.available information concerning physical/chemical properties if dibromoethyl acetate. A complete copy of the study and a discussion of the use patterns for this chemical would also be helpful. Please consider retesting the material using more sensitive experimental procedures. Please identi.fy the solvent used in this test. Also, explain why this solvent was used. Since the compound is soluble in water, an additional solvent seems unnecessary. 

### ' No additional information is requested at this time. No additional information is **requeste~** at this time. 0127

**~** l' 

### --.,-

. .,,; Please refer to the Comments/Recommendatio;,s section of th<?'· Status Report for a discussion of appropriate subtid_.s:.. s:j..Ons of substantial risk. No additional information.'i'!' requested at this time. 

# • Please refer the Status Report teratology study. this time. to the Submission Evaluation section of for comments on weaknessess iri the pilot

No additional information is requested

**~t**

### No additional information is requested at this.time. Please clarify the chemical struCture of MC 935A and provide any available data concerning the purity and phys- ical/chemical properties of this substance. 0136 

### Because of the discrepancy between the two mouse lymphoma assays, please consider retesting so that con- sistent results may be obtained.
Please provide available data on the composition, purity, and physical/chemical properties of the test substance. Also describe any pathological findings or clinical observations made on the test animals.
Please submit a copy of the attending physician's i·eport.·

·- f 

### ., 014:(

**:~** 

### ·· No additional information is requested at this time• 

## • Please supply any information on skin sensitization in· an'imals that was available to the dermatologist before the human study was done. Also, please =larify what modifications were made to the standard D%·aize test in the skin

**sensi~ization** 

### study.
No additional information is requested at this·tinie.Please clarify the chemical name for CN-llD-356 and provide a structural formula for this compound. Available information on production volume and use patterns for this chemical would also be of value to EPA.
No additional information is requested at this time. Please provide data concerning the purity of the test substand and data on the physical/chemical properties (especially water solubility) of the substance. Please provide data concerning the composition, purity, and physical/chemical properties of the test substance and submit the results of any gross pathology or histopathology performed on the test animals. Also, please discuss ourrent:, and projected use patterns for VEL 4441 and inform EPA if any plans for additional testing on this substance. :=. 0173:piease provide any available data concerning the identification of impuritiS$ in MC 984. If no data is ava,;iilable, a discussion of potential impurities would be

**h~lpful.** Also, please answer the questions raised in the "Submission Evaluation section of the status report. Please provide data concerning the composition pur;'.ty, and physical/chemical properties of the test substance. Also, please respond to the questions raised in.the "Sub-' mission Evaluation" section of the status report. c

:; '.'-11- ' ' 0175 Please provide data ccineerning the ·compositibn, pu.rity, and physical/chemical properties of the test substance and· submit the results of any gross pathology or histopathology_ performed on the test animals. Also, please discuss current and projected use patterns fcir VEL 4441 and inform·EPA'of any plans for additional testing on this substance. 0176 Please prov.ide data concerning the composition, purit·y, •and physical/chemical properties of the test substance.

Also, please describe the use patterns of this substance. 0172 Please provide data concerning the composition, purity, and physical/chemical properties of the test substance. Information related to the compound's stability and hydro• scopicity are particularly important in this case. Also, please describe the appearance of the rats' lungs upon necropsy. Did the lungs show edema or·hemorrhaging? 0179 No additional information is requested at this time. 0180 .,.. 

## --.r·

..;;' No additional information is requested at this time. :.:. No additional information is requested at this time,
No additional information is requested at this tiine• 

## .Ql!U.· Please resolve the confusion concerning the identity of the test substance. Was 2,·3-dibromopropanol a component,of the test substance? AlsO.provide any available anlytioal .. data on the composition and puri1;Y of the'test substance,·

.. ;. ; '.:.12-
No additional .information is requir\i!d at this time. Please refer to the Comments/Recommendati"ons section of the Status Report for general comments on appropriate 8(e) submissions and future activ.ities. · · Please provide any available information concerning the composition and purity of the test material. Please submit any available information concerning the use pattern of the subject chemical. Also, provide available data concerning the composition and purity of the test ·. substance. 0194 Please submit any available information concerning \:he use pattern of the subject chemical. Also, provide available data concerning the compostion and purity of the test

**.sub~** stance.' .• 0195:' --.; 

# -· :!. Please submit any available information concerning the use pattern of the subject chemical. Also, provide available data concerning the composition and purity of the test substance.

Please submit any available 'information concerning the use pattern of the subject chemical. Also;_provide available data concerning the composition and purity·of the test substance. · ··.....

.. 0197 

### Please submit any available information concerning the use pattern of the subject chemical. Ailso, prpvide available·· data concerning the composition and purity of·the test substance. · · 0199 

### No additional information iS 

### requested at this time; Please identify the "DBDCB isomer'' found on the 

### GC trace.
Please submit any available information concerning the· use patierns of the subject chemical; Also, please respond to the questions raised in the evaluation section

## of the · status report.
Please provide any available data cqncerning the·com- position a-nd purity of the test

**material.~**

•r . . . . 

### ·''Please submit an accurate chemical identity of PCS 137$, describing

# a. molecular structure and formula.con- sis-t:ent with a name. Also, please provide:·· analytical data

**~** 

### cdncerning the composition and purity of the test material, any available information on its use patterns, and the results of any experimental blood level determinations. 0205



### . Please provide analytical data concerning the com.;. position and purity of the test material. Also;'please inform EPA of any plans for further

**testing-of.~is** 

### ina;.. terial. ·· · ·· · ·

··' ·,·,.· .

**~·**0206 

### Please provide any available analytical data CC)nce'rning the identification or characterization of impurities present in the test substance. ·
No additional information is requested at this time. 0210 

### Discrepancies between the chemical name and the melee• ular formula have been a recurrent problem with Velsicol B(e) submissions. Please clarify this discrepancy .for this submission. It is the responsibility of the submitter to provide EPA with complete and accurate information, so that a proper evaluation of substantial risk can.be made. Please proofread future submissions carefully. Also, please provide a description of the use patterns of this substance. Please provide histopathological**find~** 

### · ings on the test animals. If these are not available, Velsicol should consider initiation of these studies. 0220 

### Please provide any available informatiqn conc:;erning the · use patterns and/or information of the test compound•

.

### .' o22rt · 

# __, 

## .,, :: ' Please provide any available information concerning the annual production and uses of the test compound. 0222 

### Please provide any available analytical data concerning the composition and purity of the test material. 0223 

### No additional information is requested at this time. 

## '-1

### Please provide 

## a description of the use patterns of Vel .4578. 0225 

### Please provide a description of the use patterns of vEL_ 4441.


### Please provide a description of the use patterns of methyl-m-chlorobenzoate. 0227 

### Please address the concerns raised in the Submission Evaluation section of the Status Report.
No additional information is requested at this time.
Pfease provide the chemical identity of benzofleK S-552 with 

### 1!!'..specific structure of molecular formula and chemical name.r..

.

### ' ··:t,


### .. , 

### o:<·3i No additional information is requested at.this time•. · ':.:

### CODING FORM FORSAC INDEXING REVISED10f15/S6

DT902C•04BB

LETTER FROM VELSICOL CHEMICAL CORPORATION RESPONDING TO USEPA LETTER DATED MARCH 16, 1'378 REGARDING INFORMATION ON THE POLICY STATEMENT f'1ND DATA WITH ATTACHMENT

### ·i
VELBJCOL CHEMICAL CORPCIRATION 341eASTCHICSTREET • CHtCAGO, IWNCtS60611 •**312~670·-4500** 

### April 20, 1979 Mr. Joseph J. 

### Merenda Assessment Division Office of Toxic Substances (WH-567} 

### Environmental Protection Agency 401 MStreet, SW Washington, D.C. 20460 Subject: Notification of Substantial Risk EPA Letter
- Undated Dear Mr. Merenda: In response to your attached undated letter, Velsicol's Chemical Risk Assessment Committee (CRAC} has reviewed EPA's March 16, 

### 1978 policy statement and the data within these notices. It is CRAG's determination that Velsicol does not consider the submissions discussed in your letter to contain evidence of substantial risk. Since Velsicol does not consider these as appropriate section B(e) submissions, with this letter Velsicol wishes to formally withdraw the submissions outlined in your letter. Information -':'equested·by EPA in the attachment entitled "Request for Further Information has not been included since Velsicol does not consider these as appropriate B(e) submissions.·· This_ information will be developed if the Agency wishes to**~ceive** it.. Thank 

### you for your patience in this matter. Please call us if**YO\~** have any questions. 

### Sincereiy, 

### VELSICOL CHEMICAL CORPORATION ' 

### H. Olav Messerschmidt Manager of Pro'duct Registration MOM:lb 

# .. • • 

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# ~' **~** u UNITED STATES ENVIRONMENTAL PROTECTION AGENCY "«

# _,_';! WASHINGTON, D.C. 20460


### JAN261979 Mr.

# Thomas R.

# LoyRECEiVED Manager, Regulatory

**Acti~ities** 

### 'velsi.col Chemical Corporation 341 East Ohio Street Chicago, Illinois 60611 Dear Mr. 

### Loy: OFFICEOFTOXIC

**S~SSTAHCES**



### z.he Office of Toxic Substances has performed preliminary evaluations of your submissions (idemti.fied in Attachment I) under section S(e) of the Toxic Substances Control Act (PL 94-469). The enclosed status reports are the results of those evaluations; however, these reports do not necessarily represent EPA's final conclusions on these sqbmissions. Submission of the information contained in the notices listed in Attachment I does not appear to be required under section B(e) of the Toxic Substances Control Act. Please refer to the March 16, 1978 Federal Register publication . entitled "Statement of Interpretation and Enforcement Policy; Notifi.cation of Substantial Risk" (43 FR 11110) for guidance as to the types of information which should be submitted under section S(e). If, after reviewing

**~~e** 

### policy statement and reconsidering the information contained in these notices, you conclude

**tha~** 

### any or all of the submissions listed in Attachment r are .appropriate S(e) submissions, please respond to the information requests . pertaining to those submissions. These information requests can be found on the attachment entitled "Requests for Further Information." In cases where you conclude in retrospect that an earlier submission is not appropriate under section.B(e), please notify EPA of that decision. In responding to the "Requests for Further Informq.ti.on," or in otherwise communicating with EPA regarding a previous submission under section S(e), please refer to the EPA Document COntrol Number assigned to that submission. If further information is to be provided on more than one B(e)


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### sheets for each. As 

### in tae case of initial B(e) submissions, all responses will be placed in the public file unless confidentiality is claimed according to the procedures outlined in Section Xof the March 16, 1978 policy statement. Any confidentiality claims should be supported by submission of information as described in 

### the enclosed item titled "Support. Information for Confi- · dentiality Claims." Responses to the "Requests for Further Information" should be received by the.Document Control Officer within 45 working days of the date of this letter.

'J. 

### Merenda rector ment Division Enclosures 

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