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                              CONSULTING AGREEMENT

         THIS CONSULTING AGREEMENT (this "Agreement") is made and entered into
as of the 19th day of June, 2000, by and between NeoPharm, Inc., a Delaware
corporation (the "Company"), and Unicorn Pharma Consulting, Inc., a North
Carolina corporation ("Consulting Company") and its employee, Matthew P. Rogan,
M.D. (the "Supervising Consultant" and with the Consulting Company, the
"Consultant").

         In consideration of the mutual covenants, agreements and warranties
herein contained and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties hereto agree as
follows:

1. DEFINITIONS.

         (a)  "BUSINESS" means the business of researching, developing, testing,
licensing, manufacturing, distributing and marketing pharmaceutical products
used in the treatment of cancer or any other business, operation, or commercial
endeavor that is the same or reasonably similar thereto, including any business
engaged in or conducted by the Company or its affiliates or subsidiaries at any
time during the term of this Agreement.

         (b)  "CONFIDENTIAL INFORMATION" means any information, observation,
idea, patent, design, improvements, plan, invention, trade secret or data, in
whatever form or medium, concerning the business or affairs of the Company,
including, without limitation, products, processes, inventions (whether or not
patentable or registrable under copyright or similar laws and whether or not
reduced to practice), discoveries, concepts, ideas, improvements, techniques,
methods, specifications, data, know-how, products in development, investment
opportunities, the identity of potential or actual collaborators, customers or
suppliers, records, computer software (including data and related
documentation), methods of operation, pricing and bid strategies, technical and
research data, financial information, financing plans, business or marketing
techniques, strategies, forecasts or developments, product or system ideas or
designs, and other trade secrets; PROVIDED that "Confidential Information" shall
not include any information which is in the public domain through no fault of
Consulting Company or the Supervising Consultant.

2. ACKNOWLEDGMENTS.

         (a)  As a condition to entering into this Agreement, Company requires
the receipt and performance of the covenants described herein from Consulting
Company and the Supervising Consultant, which covenants Consulting Company and
the Supervising Consultant acknowledge and agree are fair and reasonable.
Consulting Company and the Supervising Consultant acknowledge that: (i) the
Confidential Information is highly confidential and valuable, and constitutes
trade secrets, (ii) the Services rendered by the Consultant will be of a special
character which have a unique value to the Company, (iii) the terms, provisions
and restrictions contained in this Agreement are in addition to, and not in lieu
of the Illinois Trade Secrets Act, as amended from time to time.


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         (b)  Consulting Company and the Supervising Consultant further
acknowledge and agree that the Consulting Company and the Supervising Consultant
will act as independent contractors in the performance and satisfaction of their
duties and obligations under this Agreement. Accordingly, Consultant
acknowledges and agrees to be responsible for the payment of all federal, state
and local taxes arising out of or related to this Agreement and the Services (as
defined below) to be provided by the Consultant.

3. DUTIES AND RESPONSIBILITIES OF CONSULTANT. The Consultant shall provide,
principally through the Supervising Consultant, certain services to the Company
("Services") during the term of this Agreement. Such Services shall include, but
are not limited to, those Services set forth on Schedule A. Such Services shall
be performed in accordance with the highest standards, customs and ethical
principles generally applicable to the provision of services such as the
Services. The Consultant agrees that the Supervising Consultant shall dedicate a
minimum of twenty-five (25) hours per week to providing the Services to the
Company.

4. COMPENSATION. The Company shall pay to the Consulting Company Five Thousand
Dollars ($5,000) per week for each full week of Services provided by the
Consultant hereunder, but prorated for any portion of a week, as appropriate. In
addition, the Company shall reimburse the Consultant for reasonable travel and
other out-of-pocket expenses incurred in connection with the Services. The
Company will also provide, without charge to the Consultant, such support
facilities and office space at the Company's principal offices, as may be
required, in the Company's reasonable judgment, to allow the Consultant to
perform the Services. All fees paid hereunder shall be paid to the Consulting
Company. The Consulting Company shall provide invoices to the Company for
Services performed by the Consultant, and expenses incurred, on a monthly basis,
with the exception, however, that an initial payment of $5,000 shall be paid by
the Company to the Consulting Company upon execution of this Agreement, which
advance payment shall be set off against amounts thereafter invoiced by the
Consulting Company. The Company shall pay all invoices within thirty (30) days
of receipt.

5. CONFLICTS OF INTEREST. The Consultant represents and warrants to the Company
that the Consulting Company and the Supervising Consultant do not have any
relationship with a third party which would represent a conflict of interest
with the rendering of the Services or the performance of duties by the
Consultant hereunder, prevent the Consultant from entering into or carrying out
the terms of this Agreement, or present any opportunity for the disclosure of
any Confidential Information of the Company. The Consultant represents and
warrants to the Company that any information that the Consultant provides to the
Company shall not be in violation of or in conflict with the Illinois Trade
Secret Act.

6. RESTRICTIVE COVENANTS.

         (a)  COVENANTS REGARDING CONFIDENTIAL INFORMATION. The Consultant
covenants and agrees that, during the term of this Agreement and continuing
thereafter, the Consulting Company and the Supervising Consultant shall hold all
Confidential Information in the strictest confidence and shall not: (i) disclose
or make use of the Confidential Information for any purpose whatsoever other
than the performance of Services to the Company, or (ii) disclose to any person
or entity or use for the Consultant's benefit or for the benefit of others,
directly or


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indirectly, any Confidential Information. Upon the termination of this
Agreement, the Consultant shall cease use of and deliver to the Company all
Confidential Information in the possession or control of the Consultant. Prior
to disclosing any Confidential Information, pursuant to subclause (i) above, the
Consultant shall (y) obtain the prior written authorization of the Company and
(z) cause the party to whom such disclosure is made to provide the Company with
reasonable assurances (in form and substance satisfactory to the Company in its
sole and absolute discretion) that it will not further disclose such
Confidential Information without the Company's consent.

         (b)  NON-SOLICITATION & NON-INTERFERENCE. The Consultant covenants and
agrees that, except to the extent required to perform Services hereunder, during
the term of this Agreement and for a period of one (1) year thereafter, the
Consulting Company and the Supervising Consultant shall not: (i) persuade or
attempt to persuade any consultant, supplier, customer or business associates of
the Company to terminate or modify his or her or its relationship with the
Company or (ii) hire any employee or former employee of the Company or knowingly
solicit any business from any supplier or potential supplier, or customer or
potential client or business associates of the Company.

         (c)  OWNERSHIP OF CONFIDENTIAL INFORMATION. All Confidential
Information, including without limitation trade secrets, conceived, created or
acquired by the Consultant, alone or with others, during the term of or
resulting from this Agreement or any prior Services provided by the Consultant
to the Company that is within the scope of the Business is the exclusive
property of Company. The phrase "within the scope of the Business" shall be
broadly construed. The Consultant agrees to disclose promptly to the Company any
and all such Confidential Information and to assist the Company in every way to
secure the Company's rights in such Confidential Information including without
limitation any copyrights, patents, trademarks, or other rights relating
thereto.

         (d)  RETURN OF PROPERTY. The Consultant acknowledges and agrees that
all Company property, including Confidential Information, keys, credit cards,
books, manuals, records, reports, notes, contracts, customer lists, and other
information defined as confidential and proprietary in any other agreement
between the parties, copies of any of the foregoing, and any equipment furnished
to the Consultant by the Company, including, but not limited to computer
software, belong to the Company and shall be promptly returned to the Company
upon termination of this Agreement.

         (e)  DEVELOPMENTS OF THE COMPANY. All ideas, inventions, trademarks,
works of art, photographs, publishable materials, and other developments or
improvements created, conceived or developed by the Consultant, alone or with
others, during the term of this Agreement, whether or not during working hours,
that are within the scope of the Company's Business, or that relate to any
Company work or projects, shall be conclusively presumed to have been created
for or on behalf of the Company ("Developments"). The Consultant shall disclose
promptly to the Company any and all such Developments. Such Developments are the
exclusive property of the Company without the payment of consideration therefor,
and the Consultant hereby transfers, assigns and conveys all of the Consultant's
rights, titles and interests in any such Developments to the Company and agrees
to execute and deliver any documents that the Company deems


<PAGE>

necessary to effect such transfer on the demand of the Company. The Consultant
agrees to assist the Company, at its expense, to obtain patents on any such
patentable ideas, inventions, trademarks, and other developments, and agree to
execute all documents necessary to obtain such patents in the name of the
Company. This Agreement does not apply to any inventions which were made prior
to the date of this Agreement and which are listed on Schedule B attached hereto
(if any) or for which no equipment, supplies, facility or trade secret
information of the Company was used and which was developed entirely on the
Consultant's own time unless: (1) the invention relates (a) to the Business of
the Company or (b) to the Company's actual demonstratively anticipated research
or development, or (2) the invention results from any work performed by the
Supervising Consultant for the Company.

         (f)  WORK MADE FOR HIRE. The Consultant recognizes and understands that
the Consultant's duties at the Company may include the preparation of materials,
including written or graphic materials and other Developments, and that any such
materials conceived or written by Consultant shall be done as "work made for
hire" as defined and used in the Federal Copyright Act, 17 U.S.C. Section 101.
In the event of publication of such materials, the Consultant understands
that since such work is "work made for hire," the Company shall solely retain
and own all rights in such materials, including any right of copyright.

         (g)  REMEDIES. If the Consultant breaches, or threatens to commit a
breach of, this Section, the Company shall have the following rights and
remedies, each of which rights and remedies shall be independent of the other
and severally enforceable, and all of which rights and remedies shall be in
addition to, and not in lieu of, any other rights and remedies available to the
Company under law or in equity:

              (i) the right and remedy to have this Section specifically
         enforced by any court having equity jurisdiction, it being acknowledged
         and agreed that any such breach of threatened breach will cause
         irreparable injury to the Company and that money damages alone will not
         provide an adequate remedy to the Company; and

              (ii) the right and remedy to require the Consultant to account for
         and pay over to the Company all compensation, profits, monies,
         accruals, increments or other benefits derived or received by the
         Consultant as the result of any actions or transactions constituting a
         breach of this Section.

The Company may exercise its rights and remedies under this Section without the
necessity of proving actual damages or posting bond. Moreover, if the Consultant
breaches any of the provisions of this Section, the running of any restrictive
period shall be suspended during the continuance of any actual breach or
violation.

         (h)  BLUE-PENCILING. If any court determines that this Agreement, or
any part thereof, is unenforceable because of the duration of such provision or
the area covered thereby, such court shall have the power to reduce the duration
or area of such provision and, in its reduced form, such provision shall then be
enforceable and shall be enforced. If any provision of this Agreement is held by
a court to be invalid, void, or unenforceable and the court does not elect to
reduce such provision, this Agreement shall be deemed amended to delete
therefrom


<PAGE>

such provision or portion adjudicated to be invalid or unenforceable without in
any way affecting the remaining parts of this Agreement.

7. TERM AND TERMINATION. The initial term of this Agreement will be for six (6)
months and will automatically renew for successive one (1) month terms unless
prior thereto the Consultant has completed the Services hereunder or the
Consultant provides notice to Company, or the Company provides notice to the
Consultant, of an intention to terminate this Agreement no earlier than seven
(7) days after the date of such notice. Notwithstanding the foregoing, the
Company may terminate this Agreement at any time based on the Consultant's
failure to provide the Services to the reasonable satisfaction of the Company.
The Company may also terminate this Agreement based on the Consultant's failure
to comply with Paragraphs 2, 3, 5, 6, 9 and 17. Upon any termination (including
wrongful termination) of this Agreement by the Company, the Company shall only
be liable to the Consultant for Services actually provided and the Consultant
shall not be entitled to any additional compensation or payments from the
Company

         The Consultant specifically acknowledges and agrees that
notwithstanding any other provision contained herein, Sections 2, 6, 9, 14, 16,
and 17 shall survive the termination of this Agreement.

8. ENTIRE AGREEMENT; AMENDMENT; WAIVER; ASSIGNMENT. This Agreement constitutes
the entire agreement between the parties respecting the subject matter contained
herein, and supersedes all other prior agreements, contracts or arrangements and
may not be modified or amended except in a writing signed by both parties. No
waiver or discharge of any breach of this Agreement shall be effective unless it
is in a writing signed by all parties hereto. Any waiver of any breach of any
provision of this Agreement shall not be a waiver of any subsequent breach of
the same or of any other provision of this Agreement. The Consultant may not
assign or transfer this Agreement or any rights hereunder. The Company may
assign or transfer this Agreement and the rights hereunder at any time upon
providing written notice to the Consultant. This Agreement shall inure to the
benefit of Company's successors and assigns.

9. INDEMNIFICATION. The Consultant shall indemnify the Company and the Company's
respective officers, directors, independent contractors, representatives
shareholders, affiliates and subsidiaries (collectively the "Company
Affiliates") against, and agree to defend and hold harmless from, any and all
liabilities, losses, costs, damages, penalties or expenses (including, without
limitation, reasonable attorneys' fees and expenses and costs of investigation
and action, suit or proceeding) incurred or suffered by the Company or any
Company Affiliate arising out of any breach or threatened breach of this
Agreement by the Consultant.

10. WAIVER. The failure of a party hereto at any time or times to require
performance of any provision hereof shall in no manner effect its right at a
later time to enforce the same. No waiver by a party of any condition or of any
breach of any term, covenant, representation or warranty contained in this
Agreement shall be effective unless in writing, and no waiver in any one or more
instances shall be deemed to be a further or continuing waiver of any such
condition or breach in other instances or a waiver of any other condition or
breach of any other term, covenant, representation or warranty.


<PAGE>

11. COUNTERPARTS. This Agreement may be executed simultaneously in counterparts,
each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

12. HEADINGS. The headings preceding the text of Sections of this Agreement are
for convenience of reference only and shall not be deemed part of this
Agreement.

13. APPLICABLE LAW. This Agreement shall be governed by and construed enforced
in accordance with the internal laws of the State of Illinois, without regard to
its conflict of law rules.

14. VENUE; JURISDICTION.

         (a)  The Consultant irrevocably agrees that all actions or proceedings
in any way, manner or respect, arising out of or from or related to this
Agreement shall be litigated only in courts having situs within the City of
Chicago, State of Illinois. The Consultant hereby consents to the jurisdiction
of any local, state, or federal court located within said City and State and
hereby waives any objections based on improper venue or forum non conveniens to
the conduct of any proceeding instituted hereunder.

         (b)  The Consultant irrevocably waives any right to trial by jury in
any action or proceeding (i) to enforce or defend any rights under or in
connection with this Agreement or any amendment, instrument, document or
other agreement delivered or which may in the future be delivered in
connection herewith or therewith or (ii) arising from any dispute or
controversy in connection with or related to this agreement or any such
amendment, instrument, document or other agreement, and agree that any such
action or proceeding shall be tried before a court and not before a jury.

15. CONSULTATION WITH AN ATTORNEY. This Agreement is a legal document. The
Consultant is advised to consult with an attorney before signing this Agreement.

16. ATTORNEYS' FEES. In the event any legal proceeding is commenced for the
purpose of interpreting, construing, enforcing or claiming under this Agreement,
the Company shall be entitled to recover reasonable attorney fees in such
proceeding, or on any appeal therefrom

17. ILLINOIS TRADE SECRETS ACT. Without in any way limiting the Consultant's
other obligations, duties and responsibilities hereunder, the Consultant agrees
to be subject to, bound by and comply with the Illinois Trade Secrets Act, as
amended from time to time.

18. LOCATION OF WORK. The Consultant agrees that the Consultant shall perform
the Services principally at the offices of the Company set forth in paragraph
19, or such other location as the Company may reasonably request from time to
time, it being acknowledged by the Company, however, that certain aspects of the
Services may be performed, with the Company's consent, at locations other than
the Company's offices

19. NOTICES. All notices, demands, requests or communications which may be
required to be given by one party to the other party shall be in wiring, shall
be delivered either personally, by


<PAGE>

registered or certified mail, by messenger service, or by facsimile
transmission, and shall be addressed as follows:

         If to Company:                  NeoPharm, Inc.
                                         100 Corporate North, Suite 215
                                         Bannockburn, IL 60015
                                         Fax No.: (847) 295-8854
                                         Attn: James M. Hussey, President

         If to Consulting Company:       Unicorn Pharma Consulting, Inc.
                                         103 High Country Drive
                                         Cary, NC 27513
                                         Fax No.: (919) 468-1427
                                         Attn: President

         If to Supervising Consultant:   Dr. Matthew P. Rogan
                                         c/o Unicorn Pharma Consultants, Inc.
                                         103 HighCountry Drive
                                         Cary, NC   27513
                                         Fax No.: (919) 468-1427

                            [SIGNATURE PAGE FOLLOWS]


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         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first above written.

NEOPHARM, INC.                           UNICORN PHARMA CONSULTANTS, INC.

By: /s/ James M. Hussey                  By: /s/ Matthew P. Rogan, M.D.
   ---------------------------------        -------------------------------
Name:                                    Name:
   ---------------------------------        -------------------------------
Title: President & CEO                   Title: President
   ---------------------------------        -------------------------------

                                         SUPERVISING CONSULTANT:

                                             /s/ Matthew P. Rogan, M.D.
                                         ---------------------------------
                                         Matthew P. Rogan, M.D.


<PAGE>


                                   SCHEDULE A

                             DESCRIPTION OF SERVICES

         The Company wishes to enlist the Services of Unicorn Pharma Consulting,
Inc. (the "Consulting Company") and, specifically, Matthew P. Rogan, M.D. (the
"Supervising Consultant") to provide assistance to the Company's Chief
Scientific Officer ("CSO") or, in the event of a vacancy in the office of CSO,
to serve as interim CSO as needed, while a permanent CSO is being recruited.
Responsibilities will include, but not be limited to: 1) providing guidance
regarding clinical development of Company products, 2) recommending a medical
infrastructure to support efficient and cost effective conduct of the clinical
plan, 3) assisting in the identification and recruitment of professional staff
to execute the clinical plan, 4) identifying and evaluating other vendors
(contract research organizations, statisticians, case report form designers,
project managers, etc.) as necessary to assist with study conduct, 5) overseeing
the professional development of the medical staff, 6) liaising with the current
or any future CSO, 7) cultivating relationships with key opinion leaders and
investigators, and 8) performing additional tasks as requested by the President
or Board of Directors of the Company (collectively the "Services").


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                                   SCHEDULE B

         INVENTIONS MADE PRIOR TO THIS AGREEMENT AND EXCLUDED FROM
PARAGRAPH 6(e):



                                      NONE