|   |
|---|
|   |  |
| x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |

|   |
|---|
|   |  |
| o | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |

|                                                               |
|---------------------------------------------------------------|
|                                                               |  |  |
| DELAWARE                                                      |   | 47-3251758 |
| (STATE OR OTHER JURISDICTION OFINCORPORATION OR ORGANIZATION) |   | (I.R.S. EMPLOYERIDENTIFICATION NO.) |
|                                                          |   |
| 5770 Armada Drive, Carlsbad, California                       |   | 92008 |
| (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)                      |   | (ZIP CODE) |

|                                        |
|----------------------------------------|
|                                        |  |  |
| Title of Each Class                    |   | Name of Exchange on Which Registered |
| Common Stock, Par Value $.01 Per Share |   | The Nasdaq Stock Market LLC |

----

|                                   |
|-----------------------------------|
|                                   |  |  |  |
| Large accelerated filer | o | Accelerated filer | x  |
|                              |   |   |   |
| Non-accelerated filer             | o  (Do not check if a smaller reporting company) | Smaller reporting company | o |
|                              |   |   |   |
|                              |   | Emerging growth company | x  |

----

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|          |
|----------|
|          |  |
| ITEM 15. | EXHIBITS AND FINANCIAL STATEMENT SCHEDULES |

|               |
|---------------|
|               |  |  |  |  |  |  |  |  |  |  |
| EXHIBIT INDEX |
|          |   |   |   |   |   | Incorporated by Reference |
| Exhibit No.   |   | Description |   | Filed or Furnished Herewith |   | Form |   | File/Film No. |   | Date Filed |
| 2.1(a)*#      |   | Asset Purchase Agreement among SeaSpine Holdings Corporation, N.L.T Spine Ltd. and NLT Spine, Inc., dated August 17, 2016 |   |   |   | Form 10-Q |   | 001-36905-161987764 |   | 11/10/2016 |
|          |   |   |   |   |   |   |   |   |   |   |
| 2.1(b)        |   | Amendment to the Asset Purchase Agreement among SeaSpine Holdings Corporation, N.L.T Spine Ltd. and NLT Spine, Inc., dated September 26, 2016 |   |   |   | Form 10-Q |   | 001-36905-161987764 |   | 11/10/2016 |
|          |   |   |   |   |   |   |   |   |   |   |
| 2.1(c)        |   | Amendment No. 2 to Asset Purchase Agreement among SeaSpine Holdings Corporation, N.L.T Spine Ltd. and NLT Spine, Inc., dated January 31, 2017 |   |   |   | Form 10-K |   | 001-36905-17665133 |   | 3/3/2017 |
|          |   |   |   |   |   |   |   |   |   |   |
| 2.2#          |   | Separation and Distribution Agreement between Integra LifeSciences Holdings Corporation and SeaSpine Holdings Corporation, dated as of June 30, 2015 |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|          |   |   |   |   |   |   |   |   |   |   |
| 3.1           |   | Amended and Restated Certificate of Incorporation of SeaSpine Holdings Corporation |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|          |   |   |   |   |   |   |   |   |   |   |
| 3.2           |   | Amended and Restated Bylaws of SeaSpine Holdings Corporation |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|          |   |   |   |   |   |   |   |   |   |   |
| 4.1           |   | Form of Common Stock Certificate of SeaSpine Holdings Corporation |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|          |   |   |   |   |   |   |   |   |   |   |
| 4.2           |   | Form of Indenture |   |   |   | Form S-3 |   | 333-213089-161825462 |   | 8/11/2016 |
|          |   |   |   |   |   |   |   |   |   |   |
| 10.1          |   | Transition Services Agreement between Integra LifeSciences Holdings Corporation and SeaSpine Holdings Corporation, dated as of July 1, 2015 |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|          |   |   |   |   |   |   |   |   |   |   |
| 10.2          |   | Tax Matters Agreement between Integra LifeSciences Holdings Corporation and SeaSpine Holdings Corporation, dated as of July 1, 2015 |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|          |   |   |   |   |   |   |   |   |   |   |

----

|          |
|----------|
|          |  |  |  |  |  |  |  |  |  |  |
| 10.3     |   | Employee Matters Agreement between Integra LifeSciences Holdings Corporation and SeaSpine Holdings Corporation, dated as of July 1, 2015 |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.4     |   | Microfibrillar Collagen Supply Agreement between Integra LifeSciences Holdings Corporation and SeaSpine Holdings Corporation, dated as of July 1, 2015 |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.5     |   | Collagen Ceramic Supply Agreement between Integra LifeSciences Holdings Corporation and SeaSpine Holdings Corporation, dated as of July 1, 2015 |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.6     |   | Demineralized Bone Matrix and Collagen Ceramic Products Supply Agreement between Integra LifeSciences Holdings Corporation and SeaSpine Holdings Corporation, dated as of July 1, 2015 |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.7**   |   | Brian Baker Letter Agreement, dated February 25, 2015 |   |   |   | Form 8-K |   | 001-36905-15966132 |   | 7/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.8**   |   | Form of Indemnification Agreement entered into between SeaSpine Holdings Corporation and each of its directors and executive officers |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.9**   |   | SeaSpine Holdings Corporation 2015 Employee Stock Purchase Plan |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.10**  |   | Employment Agreement, by and between SeaSpine Holdings Corporation, SeaSpine Orthopedics Corporation and Keith Valentine, dated April 28, 2015 |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.11**  |   | John Bostjancic Letter Agreement, dated March 30, 2015 |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.12**  |   | John Winge Letter Agreement, dated January 22, 2015 |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.13(a) |   | Amended and Restated Lease between Salma Jason Monica Limited Partnership and SeaSpine, Inc., dated as of May 23, 2011 for property at 2384 La Miranda, Vista, CA |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.13(b) |   | Amended and Restated Lease between Salma Jason Monica Limited Partnership and SeaSpine, Inc., dated as of May 23, 2011 for property at 2302 La Miranda, Vista, CA |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |

----

|          |
|----------|
|          |  |  |  |  |  |  |  |  |  |  |
| 10.14    |   | Amended and Restated Lease between Monarch RRC Properties, LLC (assignee of original landlord, New Goodyear LTD) and IsoTis Orthobiologics, Inc., dated as of February 23, 2006, for property at 2 Goodyear, Irvine, CA (the “Irvine Industrial Real Estate Lease”) |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.15(a) |   | Amendment No. 1 to Irvine Industrial Real Estate Lease, dated as of May 26, 2011 |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.15(b) |   | Amendment No. 2 to Irvine Industrial Real Estate Lease, dated as of May 14, 2013 |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.16    |   | Sublease Agreement between SeaSpine Orthopedics Corporation, and SkinMedica, Inc., dated as of July 8, 2015 |   |   |   | Form 8-K |   | 001-36905-151103433 |   | 9/11/2015 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.17**  |   | SeaSpine Holdings Corporation Senior Leadership Retention and Severance Plan, effective January 27, 2016 |   |   |   | Form 8-K |   | 001-36905-161378936 |   | 2/2/2016 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.18**  |   | SeaSpine Holdings Corporation 2015 Incentive Award Plan Annual Incentive Program |   |   |   | Form 8-K |   | 001-36905-161472253 |   | 3/1/2016 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.19**  |   | SeaSpine Holdings Corporation Non-Employee Director Compensation Program, effective October 13, 2015 |   |   |   | Form 10-K |   | 001-36905-161510399 |   | 3/16/2016 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.20(a) |   | Credit Agreement between SeaSpine Holdings Corporation, SeaSpine Orthopedics Corporation, SeaSpine, Inc., SeaSpine Sales LLC, Theken Spine, LLC, ISOTIS Orthobiologics, Inc. and Wells Fargo Bank, National Association, as administrative agent for each member of the lender group and the bank product providers, entered into as of December 24, 2015 |   |   |   | Form 10-K |   | 001-36905-161510399 |   | 3/16/2016 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.20(b) |   | First Amendment to Credit Agreement and Waiver among SeaSpine Holdings Corporation, SeaSpine Orthopedics Corporation, SeaSpine, Inc., SeaSpine Sales LLC, Theken Spine, LLC, ISOTIS Orthobiologics, Inc. and Wells Fargo Bank, National Association, as administrative agent for each member of the lender group and the bank product providers, made as of October 14, 2016 |   |   |   | Form 10-K |   | 001-36905-17665133 |   | 3/3/2017 |
|     |   |   |   |   |   |   |   |   |   |   |
| 10.21**  |   | Amended and Restated SeaSpine Holdings Corporation Non-Employee Director Compensation Program, effective March 30, 2016 |   |   |   | Form 10-Q |   | 001-36905-161653403 |   | 5/16/2016 |
|     |   |   |   |   |   |   |   |   |   |   |

----

|            |
|------------|
|            |  |  |  |  |  |  |  |  |  |  |
| 10.22(a)** |   | SeaSpine Holdings Corporation Amended and Restated 2015 Incentive Award Plan (As Amended and Restated as of March 30, 2016) |   |   |   | Form S-8 |   | 333-211887-161700155 |   | 6/7/2016 |
|       |   |   |   |   |   |   |   |   |   |   |
| 10.22(b)** |   | First Amendment to the SeaSpine Holdings Corporation Amended and Restated 2015 Incentive Award Plan |   |   |   | Form 8-K |   | 001-36905-161841057 |   | 8/18/2016 |
|       |   |   |   |   |   |   |   |   |   |   |
| 10.22(c)** |   | SeaSpine Holdings Corporation Amended and Restated 2015 Incentive Award Plan- Form of Stock Option Grant Notice (including Stock Option Agreement) |   |   |   | Form S-8 |   | 333-211887-161700155 |   | 6/7/2016 |
|       |   |   |   |   |   |   |   |   |   |   |
| 10.22(d)** |   | SeaSpine Holdings Corporation Amended and Restated 2015 Incentive Award Plan - Form of Stock Option Grant Notice (including Stock Option Agreement) |   |   |   | Form 10 |   | 001-36905-15904590 |   | 6/1/2015 |
|       |   |   |   |   |   |   |   |   |   |   |
| 10.22(e)** |   | SeaSpine Holdings Corporation Amended and Restated 2015 Incentive Award Plan- Form of Restricted Stock Award Grant Notice and Restricted Stock Award Agreement |   |   |   | Form S-8 |   | 333-211887-161700155 |   | 6/7/2016 |
|       |   |   |   |   |   |   |   |   |   |   |
| 10.22(f)** |   | SeaSpine Holdings Corporation Amended and Restated 2015 Incentive Award Plan - Form of Restricted Stock Unit Award Grant Notice and Restricted Stock Unit Award Agreement. |   |   |   | Form 10-K |   | 001-36905-17665133 |   | 3/3/2017 |
|       |   |   |   |   |   |   |   |   |   |   |
| 10.22(g)** |   | SeaSpine Holdings Corporation Amended and Restated 2015 Incentive Award Plan - Form of Restricted Stock Unit Award Grant Notice and Restricted Stock Unit Award Agreement. (used for grants on and after February 1, 2018) |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |
|       |   |   |   |   |   |   |   |   |   |   |
| 10.23**    |   | Patrick Keran Letter Agreement, dated October 1, 2015 |   |   |   | Form 10-Q |   | 001-36905-17818719 |   | 5/5/2017 |
|       |   |   |   |   |   |   |   |   |   |   |
| 21.1       |   | Subsidiaries of the Registrant |   |   |   | Form 10-K |   | 001-36905-161510399 |   | 3/16/2016 |
|       |   |   |   |   |   |   |   |   |   |   |
| 23.1       |   | Consent of RSM US LLP, Independent Registered Public Accounting Firm |   | X |   |   |   |   |   |   |
|       |   |   |   |   |   |   |   |   |   |   |
| 23.2       |   | Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |
|       |   |   |   |   |   |   |   |   |   |   |
| 24.1       |   | Power of Attorney (included on the signatures page) |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |
|       |   |   |   |   |   |   |   |   |   |   |

----

|                |
|----------------|
|                |  |  |  |  |  |  |  |  |  |  |
| 31.1           |   | Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 |   | X |   |   |   |   |   |   |
|           |   |   |   |   |   |   |   |   |   |   |
| 31.2           |   | Certification of Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 |   | X |   |   |   |   |   |   |
|           |   |   |   |   |   |   |   |   |   |   |
| 32.1***        |   | Certification of Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 |   | X |   |   |   |   |   |   |
|           |   |   |   |   |   |   |   |   |   |   |
| 32.2***        |   | Certification of Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 |   | X |   |   |   |   |   |   |
|           |   |   |   |   |   |   |   |   |   |   |
| †101.INS |   | XBRL Instance Document |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |
|           |   |   |   |   |   |   |   |   |   |   |
| †101.SCH |   | XBRL Taxonomy Extension Schema Document |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |
|           |   |   |   |   |   |   |   |   |   |   |
| †101.CAL |   | XBRL Taxonomy Extension Calculation Linkbase Document |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |
|           |   |   |   |   |   |   |   |   |   |   |
| †101.DEF |   | XBRL Definition Linkbase Document |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |
|           |   |   |   |   |   |   |   |   |   |   |
| †101.LAB |   | XBRL Taxonomy Extension Labels Linkbase Document |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |
|           |   |   |   |   |   |   |   |   |   |   |
| †101.PRE |   | XBRL Taxonomy Extension Presentation Linkbase Document |   |   |   | Form 10-K |   | 001-36905-18663242 |   | 3/2/2018 |

----

|        |
|--------|
|        |  |  |  |
|   |   |   |   |
|   |   |   | SEASPINE HOLDINGS CORPORATION |
|   |   |   |
| Date:  | March 6, 2018 |   | /s/ Keith C. Valentine |
|   |   |   | Keith C. Valentine |
|   |   |   | President and Chief Executive Officer |