Exhibit 4.11





Lease Agreement - Appendix

Signed by and between the parties on June
2, 2003



Made and entered into in Jerusalem on
October 28, 2015



| | Between: | R.M.P.A. assets ltd.
| | -------- | --------------------

Company number
51-1808008

Which address
is 12 Hartom St., Mount Hozvim, Jerusalem

(Hereinafter
referred to for the sake of brevity as "the Lessor")



On the
one hand



| | And: | Intec Pharma Ltd. (formerly Intec Pharmaceuticals
(2000) Ltd)
| | ---- | -------------------------------------------------------------

Corporation
number 513022780

Which address
is 12 Hartom St., Mount Hozvim, Jerusalem

(Hereinafter
referred to for the sake of brevity as "the Lessee")



On the other
hand



Whereas the parties have signed a lease
agreement ("Lease Agreement") on date June 2, 2003, pursuant to which the lessee rented rental spaces located
on the 1st floor and 2nd floor of the building built on the plot known as " R.M.P.A. building" (to be called hereinafter:
"The building"), a warehouse and parking spaces, all as set forth in the Lease Agreement and its appendices;



Whereasthe lessee is interested to
extend the lease period and furthermore rent additional space on the second floor of the building;



Whereas the lessor has agreed to extend
the lease period and to lease additional space to the lessee in accordance with the terms set out specifically in this appendix;



Therefore, it was agreed, declared
and stipulated between the parties as follows: -



| | 1. | The lease period will be extended by an additional 30 months period, commencing from January 1, 2016
and until June 30, 2018.
| | -- | -----------------------------------------------------------------------------------------------------------------------------



| | 2. | The Lessee is granted an option to extend the Lease Period by a further 12 monthsperiod,commencing
on July 1, 2018 and until June 30. 2019 (hereinafter: "the "option period "). The option will be exercised automatically
unless the lessee notified the lessor that he does not intend to exercise the option, at least 150 days prior to the expiry of
the lease period.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3. | All payments in respect of the leased property, as defined in the Lease Agreement, the appendices
and addenda thereto, shall remain unchanged during the additional lease period. The rental fee, management fees, parking spaces
and the warehouse will increase by 5% over the increase in the index during the option period as it would be exercised.
| | -- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



1







| | 4. | As from January 1, 2016, an additional space (hereinafter: the "additional space")
on the second floor of the building, consisting of an area of approximately 78 square meters (m2) gross, will be added
to the leased property , in accordance with the attached sketch. This space will be added to the currently leased space of 1,814
m2 gross, 10 m2 warehouse and 19 parking spaces. There may be a possibility of advancing the delivery date
of the additional space, by a written notice to the lessor, 30 days in advance.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 5. | After the signing of the parties to this Appendix and after the delivery of the additional space on
the 2nd floor, the property will be deemed as inclusive of the additional space, as if it was included in the Lease Agreement from
the outset.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 6. | The additional space shall be leased to the lessee in its AS-IS condition, and all the adjustments
that the lessee requires, will be carried out by the lessee and at his expense. The separation of the additional space from the
rest of the office space will be carried out by the lessee and at his expense.
| | -- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 7. | The lessee states that he is aware that the additional space is installed with central air conditioning
system which is not connected to the chillers' system of the building. Should the lessee chooses to connect the additional space
to the air chillers' system, he will have to carry out the change himself and at his own expense, as well as submit work plans
for the lessor's approval, prior to the execution of the work.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 8. | The rental fees, their Linkage, the management fees and the remaining provisions of the Lease Agreement
shall apply in their entirety to this Appendix and nothing in this appendix shall derogate and / or modify the provisions of the
Lease Agreement, with the exception regarding the extension of the period and the addition of the supplement space leased by the
lessee from the lessor.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|/s/ Yair Hadar |  | /s/ Oren Mohar
|-------------- |  | --------------
|The Lessor     |  | The Lessee    





2