EXHIBIT 10.36

             AMENDMENT No. 1 TO SECURITY AND INTERCREDITOR AGREEMENT

         THIS  AMENDMENT  NO. 1,  dated as of June 7, 2000,  is to that  certain
Security and Intercreditor Agreement(the  "Agreement"),  dated December 1, 1999,
among Biofund, Inc., a Delaware corporation with an address at Box L, Millbrook,
NY 12545 ("Biofund"),  Donald C. Fresne ("Fresne"),  with an address at 69 North
Tower Hill Road,  Box L,  Millbrook,  NY 12545,  and  Epigen,  Inc.,  a Delaware
corporation with an address at North Tower Hill Road, Box L, Millbrook, NY 12545
("Epigen"). All capitalized terms used herein shall have the same meanings as in
the Agreement unless otherwise stated. In addition,  each of the shareholders of
Biofund whose names appear on the signature  page hereof are added as parties to
the Agreement to the extent set forth herein.

                                    RECITALS

         1. Epigen  obtained a loan from the Bank of  Millbrook  ("Bank") in the
original  principal  amount of up to $800,000 (the "First Loan")  secured by the
Guaranty.  The Guaranty was secured by collateral in the form of certificates of
deposit  issued by the Bank  aggregating  the original  principal  amount of the
First Loan (the  "Security").  Subsequently,  Epigen obtained an additional loan
from the Bank in the original  principal  amount of up to $120,000  (the "Second
Loan"). The Second Loan also was guaranteed by Biofund and secured by collateral
in the form of  certificates  of  deposit  issued  by the Bank  aggregating  the
original principal amount of the Second Loan (the "Additional Security").

         2. The parties to the Agreement  have agreed to modify the terms of the
arrangements  set  forth in the  Agreement  regarding  the  purchase  of  equity
securities of Epigen  pursuant to Paragraph 3.1 of the Agreement  and,  together
with the other signatories hereto to address certain other matters as herein set
forth.

         3. The  capitalization  table of Epigen attached hereto  represents the
capitalization  of Epigen,  on a fully diluted basis, as of December 31, 1999 is
attached hereto as Exhibit A.

         4. The Board of Directors  of Epigen,  at a meeting duly held on May 3,
2000, has reduced the exercise price per share of Epigen's  outstanding  options
and warrants with exercise prices of $1.00 per share or greater by one-half. The
Board of  Directors  of  Epigen,  at a meeting  duly held on June 6,  2000,  has
retired all treasury  stock of Epigen and  restored  such stock to the status of
authorized  but  unissued  stock  and has  revised  the  number  of  issued  and
outstanding  shares of Common Stock to that set forth in the records of Epigen's
transfer agent, American Stock Transfer & Trust Company.

         NOW, THEREFORE, in consideration of the foregoing and the covenants and
conditions herein contained, Biofund, Epigen and Fresne, intending to be legally
bound, hereby agree as follows:

                                      -19-

<PAGE>

         Section 1.   EXERCISE OF CONVERSION RIGHT.

         (a) As of the date hereof,  Biofund has the right to acquire  3,936,680
shares  of  Epigen's  Common  Stock at a price of $.01 per  share,  pursuant  to
Section 3.1 of the  Agreement.  Effective  immediately,  Epigen hereby grants to
Biofund the right, assignable to its shareholders,  immediately to exercise such
right.

         (b) Biofund hereby assigns to its shareholders,  pro rata, its right to
acquire  such shares of Epigen's  Common  Stock.  The number of shares of Epigen
Common  Stock each Biofund  shareholder  shall have the right to acquire and the
aggregate purchase price therefor is set forth on Exhibit B hereto. By executing
this Amendment,  each of the shareholders of Biofund hereby exercises his or her
right to acquire the shares of Epigen  Common  Stock and agrees to pay to Epigen
the purchase price for the shares to be acquired by such Biofund  shareholder by
his or her check upon his or her  execution of this  Amendment.  Each such check
shall be returned by the respective  shareholders  of Biofund to Epigen together
with such shareholder's signed copy of this Agreement.

         Section 2.   PURCHASE  OF NEW SHARES OF EPIGEN SECURITIES.

         2.1  SUBSCRIPTION  FOR  NEW  SHARES  OF  COMMON  STOCK.   Each  of  the
shareholders   of  Biofund   whose  names   appear  on  Exhibit  C  hereto  (the
"Participating  Biofund  Shareholders")  hereby  subscribes  for and  agrees  to
purchase  the  amount of  additional  shares of  Epigen  Common  Stock set forth
opposite his or her name on Exhibit C hereto at the price of $.50 per share. The
aggregate  purchase  price  for  such  shares  shall be paid to  Epigen  by each
Participating Biofund Shareholder concurrently with his or her execution of this
Amendment by wire transfer as follows:

                  Bank of Millbrook
                  P.O. Box AF
                  Millbrook, NY 12545
                  ABA No.:                  021907975
                  Account Name:             Epigen, Inc. Escrow Account
                  Account No.:              0220631
                  Contact:                  Ronald Mosca

         2.2 USE OF PROCEEDS  FROM SALE OF COMMON  STOCK.  Epigen  hereby agrees
that the entire  amount of the  proceeds  received by it pursuant to Section 2.1
hereof  shall  be used  solely  for the  purpose  of  repaying  the  outstanding
principal  amounts  of the First Loan and the  Second  Loan and to  release  the
Guaranty,  the  Security  and  the  Additional  Security.  Upon  release  of the
Guaranty,  the Security and the  Additional  Security,  Biofund shall deliver to
Epigen Termination Statements on Form UCC-3 terminating its security interest in
the Collateral.

         2.3  SUBSCRIPTION  FOR SHARES OF SERIES B PREFERRED  STOCK.  Each of W.
James Tozer  ("Tozer"),Jr.,  Lionel Goldfrank III and David Clapp (the "Series B
Purchasers")  hereby  agrees to  purchase  75,000  shares of  Epigen's  Series B
Preferred Stock, par value $.001 per share, at a price of $1.00 per share, or an
aggregate  purchase price of $225,000 (the "Series B Proceeds"),  which purchase
has been  authorized  by the Board of Directors of Epigen at its meeting held on
May 7, 2000. The relative  rights,  preferences  and privileges of such Series B
Preferred Stock are set

                                      -20-

<PAGE>

forth on Exhibit D hereto.  In  addition,  Epigen  may sell up to an  additional
275,000 shares of Series B Preferred Stock,  also at a price of $1.00 per share,
to such other existing  shareholders  of Epigen and to such other persons as its
Board of Directors may determine.

         2.4 USE OF  PROCEEDS  FROM SALE OF  SERIES B  PREFERRED  STOCK.  Epigen
hereby acknowledges receipt of the entire amount of the Series B Proceeds, which
are on  deposit at the Bank of  Millbrook,  New York in an Escrow  Account,  no.
0220631,  less the sum of $105,000  which  previously had been deposited in such
account and disbursed with the approval of a majority of the Series B Purchasers
for the purpose of paying certain  obligations  of Epigen  principally to Vacold
LLC. The balance of the Series B Proceeds  shall be used to pay  obligations  of
Epigen  principally  to Vacold LLC and for working  capital.  The balance of the
Series B Proceeds  shall be released  from  escrow upon  delivery by the parties
hereto of fully executed  counterparts  of this Amendment and delivery by Epigen
to the Series B Purchasers  of copies of the  resolutions  of Epigen's  Board of
Directors approving this Amendment and the transactions contemplated hereby.

         3.  REGISTRATION  RIGHTS.  Epigen  hereby grants to each of the Biofund
Shareholders  and the Series B  Purchasers  registration  rights with respect to
their shares of Epigen  Common  Stock and the shares of Common Stock  underlying
the shares of Series B Preferred Stock purchased  hereunder.  Such persons shall
have all of the rights and benefits,  pari passu,  with the  beneficiary  of any
registration rights agreement binding upon Epigen.

         4.  CONVERSION OF EPIGEN DEBT BY FRESNE.

         (a) As of April 30, 2000, Epigen is indebted to Fresne in the aggregate
amount  of  $1,743,378.48.   Effective  immediately,  Fresne  hereby  agrees  to
contribute to the capital of Epigen an aggregate of $1,387,164.85 in obligations
owed by Epigen to him.  Epigen shall issue to Fresne its promissory  note in the
original  principal amount of $356,213.63,  with interest thereon at the rate of
nine  percent  (9%) per  annum in the form  attached  hereto  as  Exhibit E (the
"Company  Note").  Of the principal  amount of such note,  $156,213.63  shall be
repaid in three equal  annual  installments  principal,  plus  accured  interest
thereon,  and $200,000 shall be payable on demand by Fresne shall continue to be
subject to the security  agreement  granted to Fresne  pursuant to the Agreement
dated as of May 1, 1995 between Fresne and Epigen (the "1995 Agreement").

         (b) In addition, as of the date hereof, Fresne is indebted to Epigen in
the amount of $156,213.63.  Fresne hereby agrees to repay such amount out of the
proceeds  received by him from Epigen  pursuant to the Company Note, in pro rata
installments,  if, as and when  received  by Fresne,  pursuant to the terms of a
promisory note substantially in the form of Exhibit F hereto.

         (c) Fresne hereby agrees that from and after April 30, 2000, any salary
owed to him by Epigen  which is unpaid  because  Epigen  lacks the funds to make
such payment shall accrue without interest  accruing  thereon,  any provision to
the contrary in the 1995 Agreement to the contrary notwithstanding.

         (d) Fresne  further agrees that,  notwithstanding  any provision to the
contrary  in the 1995  Agreement  to the  contrary,  he may  convert  all or any
portion of $200,000 of principal

                                      -21-

<PAGE>

amount of the Company Note only into shares of Epigen's Common Stock at the rate
of $.50 per share.

         5. INVESTMENT ANALYSIS.  Attached hereto as Exhibit G is an analysis of
the  shareholdings  of all  persons  holding of record at least 2% of the Common
Stock of Epigen,  on a fully diluted  basis,  including a listing of the shares,
options,  warrants and other rights to acquire  shares of Common Stock of Epigen
and the amounts invested by such persons, or good faith estimates thereof.

         6.  WAIVER OF  ANTI-DILUTION  RIGHTS.  Each of Fresne  and Tozer  holds
certain rights to receive  additional  shares of Epigen's  Common Stock,  in the
case of  Fresne  pursuant  to  that  certain  Amended  and  Restated  Employment
Agreement  with Epigen dated as of November 1, 1999,  and, in the case of Tozer,
pursuant to that certain letter  agreement dated as of May 4, 1998.  Solely with
respect to the issuances of the Series B Preferred  Stock  contemplated  hereby,
each of Fresne  and Tozer  hereby  permanently  waives his  respective  right to
receive additional shares of Epigen's Common Stock pursuant to such agreements.

         Section 7.   MISCELLANEOUS.

         7.1  NOTICES.  Except  as herein  provided,  all  notices  which may be
required  or  permitted  under  this  Agreement  shall be given  in  writing  by
certified mail, return receipt requested, or by hand, by facsimile or by Express
Mail or other  recognized over night delivery  service and shall be delivered or
transmitted to the parties hereto at their respective addresses set forth above,
or in the case of the Biofund  Shareholders,  their respective  addresses as set
forth in the books and records of Epigen, or such other addresses as any of them
shall designate in accordance with the provisions of this Section 7.1

         7.2  ENTIRE AGREEMENT.  This Agreement constitutes the entire agreement
of the parties  hereto  regarding the subject  matter hereof and  supersedes any
prior agreement of the parties hereto regarding such subject matter.

         7.3  GOVERNING LAW. This Agreement shall be governed by and interpreted
in accordance with the laws of the State of New York.

         7.4  COUNTERPARTS.  This  Agreement  may  be  signed  in  one  or  more
counterparts which together shall constitute one and the same instrument.

         7.5  MODIFICATION. No modification or amendment of this Agreement shall
be effective unless in writing and signed by the parties hereto.

         7.6  SEVERABILITY. Should any provision of this Agreement be determined
to be  invalid  or  unenforceable  or at  variance  with any  present  or future
requirement of applicable law then such provision alone shall become inoperative
to the extent necessary,  and this Agreement may remain in full force and should
be  construed  so as to give  effect to the intent and purpose of the parties to
the maximum extent possible.

                                      -22-

<PAGE>

         7.7  ASSIGNMENT.  Except as herein provided, no party may assign all or
any portion of this  Agreement  without the prior  written  consent of the other
parties.

         7.8  HEADINGS.  The headings  contained in this  Agreement  are for the
convenience  of  reference  only and shall not affect in any way the  meaning or
interpretation of this Agreement.

                                      -23-

<PAGE>



         IN WITNESS  WHEREOF,  the parties  hereto have caused this Agreement to
executed by their duly authorized  representatives  as of the day and year first
above written.

BIOFUND, INC.                          EPIGEN, INC.

By:/s/David Clapp                      By: /s/Donald C. Fresne
   ----------------------                  ---------------------
   David Clapp, President                 Donald C. Fresne, CEO,
                                        President and Chairman

/s/Donald C. Fresne                    /s/ W. James Tozer, Jr.
-------------------------              -------------------------
Donald C. Fresne,                      W. James Tozer, Jr.
individually

/s/David Clapp                         /s/ Raju L. Shah
-------------------------              -------------------------
David Clapp,                           Raju L. Shah
individually

/s/ Farran Tozer Brown                 /s/ Robert J. Corsglia
-------------------------              -------------------------
Farran Tozer Brown                     Robert J. Corsiglia

/s/ Richard D. Field                   /s/ Lionel Goldfrank III
-------------------------              ------------------------
Richard D. Field                       Lionel Goldfrank III

/s/ Katherine Tozer Roddy              /s/ Christy Parsons
-------------------------              -------------------------
Katherine Tozer Roddy                  Christy Parsons

                                      -24-

<PAGE>

                                    EXHIBIT A


Capitalization Table as of December 31, 1999.

<TABLE>

Epigen Inc.
Full Ownership Analysis
12/31/1999
<CAPTION>
                                                                                      ----------------- Options ------------------
         Shareholder Name                                Total Shares   % Owned       Options    No. Detail    Price        Expire
         ----------------                                ------------   -------       -------    ----------    -----        ------
<S>                                                      <C>            <C>           <C>        <C>           <C>          <C>
Venture Capital Investor .............                         0           --            --           --         --           --
Biofund, Inc. (23% Sale) .............          920            0           --            --           --         --           --
     Brown, Farran Tozer .............           25            0           --            --           --         --           --
     Clapp, David ....................          200            0           --            --           --         --           --
     Corsiglia, Robert J .............           25            0           --            --           --         --           --
     Field, Richard D ................          100            0           --            --           --         --           --
     Fresne, Donald C ................           50            0           --            --           --         --           --
     Goldfrank, III, Lionel ..........          150            0           --            --           --         --           --
     Parson, Christy .................          120            0           --            --           --         --           --
     Roddy, Katherine Tozer ..........           25            0           --            --           --         --           --
     Shah, Raju L ....................           25            0           --            --           --         --           --
     Tozer, Jr., W. James ............          200            0           --            --           --         --           --
Biofund Conversion ...................          920            0           --            --           --         --           --
     Brown, Farran Tozer .............           25            0           --            --           --         --           --
     Clapp, David ....................          200            0           --            --           --         --           --
     Corsiglia, Robert J .............           25            0           --            --           --         --           --
     Field, Richard D ................          100            0           --            --           --         --           --
     Fresne, Donald C ................           50            0           --            --           --         --           --
     Goldfrank, III, Lionel ..........          150            0           --            --           --         --           --
     Parson, Christy .................          120            0           --            --           --         --           --
     Roddy, Katherine Tozer ..........           25            0           --            --           --         --           --
     Shah, Raju L ....................           25            0           --            --           --         --           --
     Tozer, Jr., W. James ............          200            0           --            --           --         --           --
Mayday Financing ($1.00 per share) ...                         0           --            --           --         --           --
Accrued Interest / Notes Payable .....                         0           --            --           --         --           --
Payables to be Converted .............                         0           --            --           --         --           --
AST Exchange Agent ...................                         0           --            --           --         --           --
** Aminoff, Cary .....................                         0                         --           --         --           --
Biotag Inc ...........................                    17,026         0.30%           --           --         --           --
BMA ..................................                         0           --            --           --         --           --
JMG Bonfrer ..........................                    10,000        0.17%            --           --         --           --
Boston Biomedical Research Institute .                    41,988        0.73%            --           --         --           --
Buttyan, Ralph .......................                     1,137        0.02%            --           --         --           --
Cede & Co ............................                   159,708        2.79%            --           --         --           --
Chandler, Joseph .....................                     2,273        0.04%            --           --         --           --
Charbit, Ingrid ......................                    50,000        0.87%            --           --         --           --
Clapp, David .......................                      50,000        0.87%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Clapp Tte./Indian Creek Ptnrs ........                   156,845        2.74%            --           --         --           --
Codington, John F ....................                    18,826        0.33%            --           --         --           --
**Corsiglia, Robert J ................                   114,940        2.01%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Creative Biomolecules Inc ............                    22,565        0.39%            --           --         --           --
Daly, Daniel .........................                     4,268        0.07%            --           --         --           --
Deidrick, Aga B ......................                     8,000        0.14%            --           --         --           --
** Dr. Crawford ......................                         0          --             --           --         --           --
** Dr. Brauer ........................                         0          --             --           --         --           --
# Epigen Inc .........................                     1,173        0.02%            --           --         --           --
Experta Treyhand AG ..................                    14,773        0.26%            --           --         --           --
Fawwaz, Rashid .......................                     9,777        0.17%            --           --         --           --
Field, Richard .......................                   100,000        1.75%            --           --         --           --
*Fresne, Donald C ....................                 2,262,722       39.52%            --           --         --           --
      Prefered Stock .................                         0          --             --           --         --           --
     ##  Debt ........................                         0          --             --           --         --           --
Gelb, William ........................                     4,850        0.08%            --           --         --           --
Gelber, Cohava .......................                    10,000        0.17%            --           --         --           --
Goluboff, Eric .......................                     6,819        0.12%            --           --         --           --
Goldfrank, L .........................                   100,000        1.75%            --           --         --           --
Harley, Colin K ......................                    98,069        1.71%            --           --         --           --
Hilkens, John ........................                    10,000        0.17%            --           --         --           --
Hilton, Birgitt ......................                    12,500        0.22%            --           --         --           --
Hilton, Louis ........................                     9,091        0.16%            --           --         --           --
                                                               0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Howard, Reese E ......................                       467        0.01%           2,332         --        2.00      12/03/2002
                                                               0          --             --          1,931      2.00      03/25/2002
--                                                             0          --             --            401      2.00      12/03/2002
Johns, Marshall J & Marlene B ........                    25,000        0.44%            --           --         --           --
Kent, Richard E**** ..................                   177,589        3.10%          59,873         --        0.82      09/01/2007
--                                                             0          --             --          1,931      2.00      03/25/2002
--                                                             0          --             --            401      2.00      12/02/2002
--                                                             0          --             --          2,136      2.00      09/13/2001
--                                                             0          --             --          1,681      2.00      06/01/2002
--                                                             0          --             --          1,681      2.00      06/01/2003
--                                                             0          --             --          1,681      2.00      06/01/2004
--                                                             0          --             --          1,681      2.00      06/01/2005
--                                                             0          --             --         47,000      0.50      09/01/2007
--                                                             0          --             --          1,681      2.00      06/01/2006
--                                                             0          --             --           --         --           --
** Krane, Robert J ...................                     6,819        0.12%            --           --         --           --
Kuter, I .............................                         0          --             --           --         --           --
Lawson, Carole .......................                    10,000        0.17%            --           --         --           --
Ledbetter Moore & Associates Inc .....                     2,273        0.04%            --           --         --           --
Levin, Bruce .........................                     1,313        0.02%            --           --         --           --
Liss, Irvine .........................                    50,000        0.87%            --           --         --           --
Long, Leo William ....................                   214,869        3.75%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Martin E Janis & Company Inc .........                     2,534        0.04%            --           --         --           --
Mondschein, Lawrence .................                     5,910        0.10%            --           --         --           --
Mongiardo, James F ...................                   126,769        2.21%           2,273        2,273      2.00      02/01/2001
Montgomery, Deborah ..................                     8,000        0.14%            --           --         --           --
Moore, Nancy K .......................                    25,000        0.44%            --           --         --           --
Nikrui, Najosam ......................                     1,137        0.02%            --           --         --           --
** Olsson, Carl ......................                     6,819        0.12%            --           --         --           --
Paulsen, D ...........................                         0          --             --           --         --           --
Perisher Publishing ..................                    75,000        1.31%            --           --         --           --
Philadep & Co. .......................                         0          --             --           --         --           --
Potter, Ransel .......................                    21,685        0.38%            --           --         --           --
Rabinowitz, Jonathan D ...............                    30,125        0.53%            --           --         --           --
Rabinowitz, Joshua W .................                    30,125        0.53%            --           --         --           --
Rabinowitz, Peter D ..................                    30,125        0.53%            --           --         --           --
Rabinowitz, Rene S ...................                    30,125        0.53%            --           --         --           --
Rykowski, Emilia c/oRabinowitz .......                    30,125        0.53%            --           --         --           --
Rabinowitz, Rubin ....................                   124,628        2.18%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Richards & O'Neil LLP ................                     6,876        0.12%            --           --         --           --
Roberts, Paul ........................                     3,000        0.05%            --           --         --           --
Sandel Robert A ......................                   115,362        2.01%            --           --         --           --
Sandel Robert A  & Eleanor J .........                    27,273        0.48%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Schroder, L Courtney .................                   143,290        2.50%           2,106         --        2.00      03/25/2002
--                                                             0          --             --          1,705      2.00      03/25/2002
--                                                             0          --             --            401      2.00      12/03/2000
Schubach, Clark ......................                     1,516        0.03%            --           --         --           --
Smith. David H .......................                     6,423        0.11%            --           --         --           --
Somkey SA ............................                     1,273        0.02%            --           --         --           --
Sterman, Marshall ....................                       108        0.00%           2,106         --        2.00      03/25/2002
--                                                             0          --             --          1,705      2.00      03/25/2002
--                                                             0          --             --            401      2.00      12/03/2000
Strategica Group Inc .................                     1,470        0.03%            --           --         --           --
The Mayflower Group Ltd ..............                    68,182        1.19%            --           --         --           --
** 'Tozer Jr., W. James (<9/1/98) ....                   434,187        7.58%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Tozer Jr., W. James (>9/1/98) ........                    50,000        0.87%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Tozer Jr., W. James (>9/1/98) ........                         0          --             --           --         --           --
Tozer Jr., W. James (IRA)c ...........                    11,819        0.21%            --           --         --           --
Vacold, LLC ..........................                   433,705        7.58%            --           --         --           --
Weil, Steven & Janet .................                    10,000        0.17%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Westheimer, J. & A ...................                    12,500        0.22%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Westheimer, Laura ....................                    12,500        0.22%            --           --         --           --
--                                                             0          --             --           --         --           --
--                                                             0          --             --           --         --           --
Zahav Ltd ............................                    30,304        0.53%            --           --         --           --
Shareholders with less than1000 Shares                    21,802        0.38%             401          401       --           --
Variance: AST Exhange Variance .......                         1

                                                       ---------      ------           ------       ------
*TOTAL ...............................                 5,725,378      100.00%          69,091       69,091
                                                       =========      ======           ======       ======


<CAPTION>
                                                          -------------------- Warrants -----------------------       **Grant
         Shareholder Name                                 Warrants     No. Detail        Price         Expire       Commitments
         ----------------                                 --------     ----------        -----         ------       -----------
<S>                                                      <C>           <C>              <C>          <C>            <C>
Venture Capital Investor .............                        --           --           --               --              --
Biofund, Inc. (23% Sale) .............          920      3,936,680         --              0.01      note payoff         --
     Brown, Farran Tozer .............           25           --        106,975            0.01      note payoff         --
     Clapp, David ....................          200           --        855,800            0.01      note payoff         --
     Corsiglia, Robert J .............           25           --        106,975            0.01      note payoff         --
     Field, Richard D ................          100           --        427,900            0.01      note payoff         --
     Fresne, Donald C ................           50           --        213,950            0.01      note payoff         --
     Goldfrank, III, Lionel ..........          150           --        641,850            0.01      note payoff         --
     Parson, Christy .................          120           --        513,480            0.01      note payoff         --
     Roddy, Katherine Tozer ..........           25           --        106,975            0.01      note payoff         --
     Shah, Raju L ....................           25           --        106,975            0.01      note payoff         --
     Tozer, Jr., W. James ............          200           --        855,800            0.01      note payoff         --
Biofund Conversion ...................          920              0         --              0.50          --              --
     Brown, Farran Tozer .............           25           --              0            0.50          --              --
     Clapp, David ....................          200           --              0            0.50          --              --
     Corsiglia, Robert J .............           25           --              0            0.50          --              --
     Field, Richard D ................          100           --              0            0.50          --              --
     Fresne, Donald C ................           50           --              0            0.50          --              --
     Goldfrank, III, Lionel ..........          150           --              0            0.50          --              --
     Parson, Christy .................          120           --              0            0.50          --              --
     Roddy, Katherine Tozer ..........           25           --              0            0.50          --              --
     Shah, Raju L ....................           25           --              0            0.50          --              --
     Tozer, Jr., W. James ............          200           --              0            0.50          --              --
Mayday Financing ($1.00 per share) ...                        --           --           --               --              --
Accrued Interest / Notes Payable .....                        --           --           --               --              --
Payables to be Converted .............                        --           --           --               --              --
AST Exchange Agent ...................                        --           --           --               --              --
** Aminoff, Cary .....................                        --           --           --               --              --
Biotag Inc ...........................                        --           --           --               --              --
BMA ..................................                        --           --           --               --              --
JMG Bonfrer ..........................                        --           --           --               --              --
Boston Biomedical Research Institute .                        --           --           --               --              --
Buttyan, Ralph .......................                        --           --           --               --              --
Cede & Co ............................                        --           --           --               --              --
Chandler, Joseph .....................                        --           --           --               --              --
Charbit, Ingrid ......................                      50,000       50,000            1.50      08/31/2001          --
Clapp, David .......................                       118,182         --              1.79      various             --
--                                                            --          9,091            2.00      12/31/2001          --
--                                                            --          9,091            2.00      12/31/2001          --
--                                                            --         50,000            1.50      03/31/2004          --
--                                                            --         50,000            2.00      03/31/2004          --
Clapp Tte./Indian Creek Ptnrs ........                       4,546        4,546            2.00      09/01/2000          --
Codington, John F ....................                       9,091        9,091            2.00      02/28/2004          --
**Corsiglia, Robert J ................                      41,725         --              2.30      various           48,527
--                                                            --          4,546            2.00      09/01/2000          --
--                                                            --          9,091            2.00      12/31/2001          --
--                                                            --          9,091            2.00      12/31/2001          --
--                                                            --         18,997            2.66      01/16/2003          --
Creative Biomolecules Inc ............                        --           --           --               --              --
Daly, Daniel .........................                        --           --           --               --              --
Deidrick, Aga B ......................                        --           --           --               --              --
** Dr. Crawford ......................                        --           --           --               --            25,000
** Dr. Brauer ........................                        --           --           --               --            25,000
# Epigen Inc .........................                        --           --           --               --            (1,173)
Experta Treyhand AG ..................                        --           --           --               --              --
Fawwaz, Rashid .......................                       9,091        9,091            2.00      02/28/2004          --
Field, Richard .......................                     100,000      100,000            3.00      06/30/2004          --
*Fresne, Donald C ....................                      25,702         --              0.90      various             --
      Prefered Stock .................                        --         24,702            0.83      04/15/2003          --
     ##  Debt ........................                        --          1,000            2.66      12/31/2002          --
Gelb, William ........................                        --           --           --               --              --
Gelber, Cohava .......................                        --           --           --               --              --
Goluboff, Eric .......................                        --           --           --               --              --
Goldfrank, L .........................                     100,000      100,000            3.00      06/30/2004          --
Harley, Colin K ......................                        --           --           --               --              --
Hilkens, John ........................                        --           --           --               --              --
Hilton, Birgitt ......................                        --           --           --               --              --
Hilton, Louis ........................                       4,546         --              2.00      12/31/2001          --
                                                              --          2,273            2.00      12/31/2001          --
--                                                            --          2,273            2.00      12/31/2001          --
Howard, Reese E ......................                        --           --           --               --              --
                                                              --           --           --               --              --
--                                                            --           --           --               --              --
Johns, Marshall J & Marlene B ........                       4,546        4,546            2.00      09/01/2000          --
Kent, Richard E**** ..................                        --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
** Krane, Robert J ...................                        --           --           --               --           160,000
Kuter, I .............................                       2,273        2,273            2.00      02/28/2004          --
Lawson, Carole .......................                        --           --           --               --              --
Ledbetter Moore & Associates Inc .....                        --           --           --               --              --
Levin, Bruce .........................                        --           --           --               --              --
Liss, Irvine .........................                      50,000       50,000            1.50      10/31/2001          --
Long, Leo William ....................                     229,734         --              2.11      various             --
--                                                            --         18,182            2.00      11/21/2000          --
--                                                            --          9,091            2.00      02/09/2001          --
--                                                            --          9,091            2.00      02/09/2001          --
--                                                            --          9,091            2.00      06/30/2001          --
--                                                            --          9,091            2.00      06/30/2001          --
--                                                            --         75,188            2.66      01/21/2003          --
--                                                            --         50,000            1.50      03/31/2004          --
--                                                            --         50,000            2.00      03/31/2004          --
Martin E Janis & Company Inc .........                        --           --           --               --              --
Mondschein, Lawrence .................                       2,273        2,273            2.00      09/01/2000          --
Mongiardo, James F ...................                        --           --           --               --              --
Montgomery, Deborah ..................                        --           --           --               --              --
Moore, Nancy K .......................                        --           --           --               --              --
Nikrui, Najosam ......................                       2,273        2,273            2.00      02/28/2004          --
** Olsson, Carl ......................                       6,819        6,819            2.00      02/28/2004       100,000
Paulsen, D ...........................                       6,819        6,819            2.00      02/28/2004          --
Perisher Publishing ..................                        --           --           --               --              --
Philadep & Co. .......................                        --           --           --               --              --
Potter, Ransel .......................                        --           --           --               --              --
Rabinowitz, Jonathan D ...............                        --           --           --               --              --
Rabinowitz, Joshua W .................                        --           --           --               --              --
Rabinowitz, Peter D ..................                        --           --           --               --              --
Rabinowitz, Rene S ...................                        --           --           --               --              --
Rykowski, Emilia c/oRabinowitz .......                        --           --           --               --              --
Rabinowitz, Rubin ....................                     128,423         --              1.35      various             --
--                                                            --          9,091            2.00      12/31/2001          --
--                                                            --          9,091            2.00      12/31/2001          --
--                                                            --         60,241            0.83      04/15/2003          --
--                                                            --         25,000            1.50      03/31/2004          --
--                                                            --         25,000            2.00      03/31/2004          --
Richards & O'Neil LLP ................                        --           --           --               --              --
Roberts, Paul ........................                        --           --           --               --              --
Sandel Robert A ......................                        --           --           --               --              --
Sandel Robert A  & Eleanor J .........                      22,720         --              2.00      various             --
--                                                            --          9,091            2.00      09/01/2000          --
--                                                            --          3,637            2.00      03/21/2001          --
--                                                            --          2,723            2.00      10/23/2000          --
--                                                            --          2,723            2.00      10/23/2000          --
--                                                            --          2,273            2.00      06/30/2001          --
--                                                            --          2,273            2.00      06/30/2001          --
Schroder, L Courtney .................                        --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
Schubach, Clark ......................                        --           --           --               --              --
Smith. David H .......................                      11,364       11,364            2.00          --              --
Somkey SA ............................                        --           --           --               --              --
Sterman, Marshall ....................                        --           --           --               --              --
--                                                            --           --           --               --              --
--                                                            --           --           --               --              --
Strategica Group Inc .................                        --           --           --               --              --
The Mayflower Group Ltd ..............                        --           --           --               --              --
** 'Tozer Jr., W. James (<9/1/98) ....                     304,546         --              1.01      various          960,992
--                                                            --          4,546            2.00      09/01/2000          --
--                                                            --        300,000            1.00      08/31/2003          --
Tozer Jr., W. James (>9/1/98) ........                     100,000         --              1.75      various             --
--                                                            --         50,000            1.50      03/31/2004          --
--                                                            --         50,000            2.00      03/31/2004          --
Tozer Jr., W. James (>9/1/98) ........                        --           --           --               --              --
Tozer Jr., W. James (IRA)c ...........                        --           --           --               --              --
Vacold, LLC ..........................                        --           --           --               --              --
Weil, Steven & Janet .................                      20,000         --              1.75      03/31/2004          --
--                                                            --         10,000            1.50      03/31/2004          --
--                                                            --         10,000            2.00      03/31/2004          --
Westheimer, J. & A ...................                      25,000         --              1.75      03/31/2004          --
--                                                            --         12,500            1.50      03/31/2004          --
--                                                            --         12,500            2.00      03/31/2004          --
Westheimer, Laura ....................                      25,000         --              1.75      03/31/2004          --
--                                                            --         12,500            1.50      03/31/2004          --
--                                                            --         12,500            2.00      03/31/2004          --
Zahav Ltd ............................                        --           --           --               --              --
Shareholders with less than1000 Shares                        --           --           --               --              --
Variance: AST Exhange Variance .......

                                                         ---------    ---------                                     ---------
*TOTAL ...............................                   5,341,353    5,341,353                                     1,318,346
                                                         =========    =========                                     =========



<CAPTION>
                                                          Convertible   Con. Sec.     Principal      Conv.
         Shareholder Name                                 Securities     Detail        Amount        Rate         Yield
         ----------------                                 -----------   ---------     ---------      ----         -----
<S>                                                       <C>           <C>           <C>           <C>           <C>
Venture Capital Investor .............                        --           --           --           --            --
Biofund, Inc. (23% Sale) .............          920           --           --           --           --            --
     Brown, Farran Tozer .............           25           --           --           --           --            --
     Clapp, David ....................          200           --           --           --           --            --
     Corsiglia, Robert J .............           25           --           --           --           --            --
     Field, Richard D ................          100           --           --           --           --            --
     Fresne, Donald C ................           50           --           --           --           --            --
     Goldfrank, III, Lionel ..........          150           --           --           --           --            --
     Parson, Christy .................          120           --           --           --           --            --
     Roddy, Katherine Tozer ..........           25           --           --           --           --            --
     Shah, Raju L ....................           25           --           --           --           --            --
     Tozer, Jr., W. James ............          200           --           --           --           --            --
Biofund Conversion ...................          920           --           --           --           --            --
     Brown, Farran Tozer .............           25           --           --           --           --            --
     Clapp, David ....................          200           --           --           --           --            --
     Corsiglia, Robert J .............           25           --           --           --           --            --
     Field, Richard D ................          100           --           --           --           --            --
     Fresne, Donald C ................           50           --           --           --           --            --
     Goldfrank, III, Lionel ..........          150           --           --           --           --            --
     Parson, Christy .................          120           --           --           --           --            --
     Roddy, Katherine Tozer ..........           25           --           --           --           --            --
     Shah, Raju L ....................           25           --           --           --           --            --
     Tozer, Jr., W. James ............          200           --           --           --           --            --
Mayday Financing ($1.00 per share) ...                        --           --           --           --            0.0%
Accrued Interest / Notes Payable .....                    245,163      245,163          --          1.00           --
Payables to be Converted .............                        --           --           --          0.00           --
AST Exchange Agent ...................                        --           --           --           --            --
** Aminoff, Cary .....................                      11,429       11,429       20,000        1.75           0.0%
Biotag Inc ...........................                        --           --           --           --            --
BMA ..................................                        --           --           --           --            --
JMG Bonfrer ..........................                        --           --           --           --            --
Boston Biomedical Research Institute .                        --           --           --           --            --
Buttyan, Ralph .......................                        --           --           --           --            --
Cede & Co ............................                        --           --           --           --            --
Chandler, Joseph .....................                        --           --           --           --            --
Charbit, Ingrid ......................                        --           --           --           --            --
Clapp, David .......................                       100,000      100,000      100,000        1.00          14.0%
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Clapp Tte./Indian Creek Ptnrs ........                        --           --           --           --            --
Codington, John F ....................                        --           --           --           --            --
**Corsiglia, Robert J ................                        --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Creative Biomolecules Inc ............                        --           --           --           --            --
Daly, Daniel .........................                        --           --           --           --            --
Deidrick, Aga B ......................                        --           --           --           --            --
** Dr. Crawford ......................                        --           --           --           --            --
** Dr. Brauer ........................                        --           --           --           --            --
# Epigen Inc .........................                        --           --           --           --            --
Experta Treyhand AG ..................                        --           --           --           --            --
Fawwaz, Rashid .......................                        --           --           --           --            --
Field, Richard .......................                        --           --           --           --            --
*Fresne, Donald C ....................                   3,683,680         --           --           --            --
      Prefered Stock .................                        --        600,000      300,000        0.50           0.0%
     ##  Debt ........................                        --      3,083,680    1,226,848        0.50           9.0%
Gelb, William ........................                        --           --           --           --            --
Gelber, Cohava .......................                        --           --           --           --            --
Goluboff, Eric .......................                        --           --           --           --            --
Goldfrank, L .........................                        --           --           --           --            --
Harley, Colin K ......................                        --           --           --           --            --
Hilkens, John ........................                        --           --           --           --            --
Hilton, Birgitt ......................                      25,000       25,000       25,000        1.00          25.0%
Hilton, Louis ........................                        --           --           --           --            --
                                                              --           --           --           --            --
--                                                            --           --           --           --            --
Howard, Reese E ......................                        --           --           --           --            --
                                                              --           --           --           --            --
--                                                            --           --           --           --            --
Johns, Marshall J & Marlene B ........                        --           --           --           --            --
Kent, Richard E**** ..................                     196,000         --           --           --            --
--                                                            --         25,000       25,000        1.00          25.0%
--                                                            --        171,000       85,500        0.50           --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
** Krane, Robert J ...................                        --           --           --           --            --
Kuter, I .............................                        --           --           --           --            --
Lawson, Carole .......................                        --           --           --           --            --
Ledbetter Moore & Associates Inc .....                        --           --           --           --            --
Levin, Bruce .........................                        --           --           --           --            --
Liss, Irvine .........................                        --           --           --           --            --
Long, Leo William ....................                    100,000      100,000       100,000        1.00           --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Martin E Janis & Company Inc .........                        --           --           --           --            --
Mondschein, Lawrence .................                        --           --           --           --            --
Mongiardo, James F ...................                        --           --           --           --            --
Montgomery, Deborah ..................                        --           --           --           --            --
Moore, Nancy K .......................                      50,000       50,000       50,000        1.00          25.0%
Nikrui, Najosam ......................                        --           --           --           --            --
** Olsson, Carl ......................                        --           --           --           --            --
Paulsen, D ...........................                        --           --           --           --            --
Perisher Publishing ..................                        --           --           --           --            --
Philadep & Co. .......................                        --           --           --           --            --
Potter, Ransel .......................                        --           --           --           --            --
Rabinowitz, Jonathan D ...............                        --           --           --           --            --
Rabinowitz, Joshua W .................                        --           --           --           --            --
Rabinowitz, Peter D ..................                        --           --           --           --            --
Rabinowitz, Rene S ...................                        --           --           --           --            --
Rykowski, Emilia c/oRabinowitz .......                        --           --           --           --            --
Rabinowitz, Rubin ....................                      75,000       75,000       75,000        1.00          25.0%
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Richards & O'Neil LLP ................                        --           --           --           --            --
Roberts, Paul ........................                        --           --           --           --            --
Sandel Robert A ......................                      50,000       50,000       50,000        1.00          25.0%
Sandel Robert A  & Eleanor J .........                        --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Schroder, L Courtney .................                        --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Schubach, Clark ......................                        --           --           --           --            --
Smith. David H .......................                        --           --           --           --            --
Somkey SA ............................                        --           --           --           --            --
Sterman, Marshall ....................                        --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Strategica Group Inc .................                        --           --           --           --            --
The Mayflower Group Ltd ..............                        --           --           --           --            --
** 'Tozer Jr., W. James (<9/1/98) ....                        --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Tozer Jr., W. James (>9/1/98) ........                     100,000      100,000       50,000        0.50           --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Tozer Jr., W. James (>9/1/98) ........                      25,000       25,000       25,000        1.00          25.0%
Tozer Jr., W. James (IRA)c ...........                        --           --           --           --            --
Vacold, LLC ..........................                        --           --           --           --            --
Weil, Steven & Janet .................                        --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Westheimer, J. & A ...................                        --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Westheimer, Laura ....................                        --           --           --           --            --
--                                                            --           --           --           --            --
--                                                            --           --           --           --            --
Zahav Ltd ............................                        --           --           --           --            --
Shareholders with less than1000 Shares                        --           --           --           --            --
Variance: AST Exhange Variance .......

                                                         ---------    ---------    ---------
*TOTAL ...............................                   4,661,272    4,661,272    2,132,348
                                                         =========    =========    =========



<CAPTION>

                                                            Interest               ----- Fully Diluted -----
         Shareholder Name                                  12/31/1999      Notes      Shares         % Owned
         ----------------                                  ----------      -----      ------         -------
<S>                                                        <C>             <C>      <C>              <C>
Venture Capital Investor .............                         --           --              0           --
Biofund, Inc. (23% Sale) .............          920            --           --      3,936,680          23.00%
     Brown, Farran Tozer .............           25            --           --              0           --
     Clapp, David ....................          200            --           --              0           --
     Corsiglia, Robert J .............           25            --           --              0           --
     Field, Richard D ................          100            --           --              0           --
     Fresne, Donald C ................           50            --           --              0           --
     Goldfrank, III, Lionel ..........          150            --           --              0           --
     Parson, Christy .................          120            --           --              0           --
     Roddy, Katherine Tozer ..........           25            --           --              0           --
     Shah, Raju L ....................           25            --           --              0           --
     Tozer, Jr., W. James ............          200            --           --              0           --
Biofund Conversion ...................          920            --           --              0           --
     Brown, Farran Tozer .............           25            --           --              0           --
     Clapp, David ....................          200            --           --              0           --
     Corsiglia, Robert J .............           25            --           --              0           --
     Field, Richard D ................          100            --           --              0           --
     Fresne, Donald C ................           50            --           --              0           --
     Goldfrank, III, Lionel ..........          150            --           --              0           --
     Parson, Christy .................          120            --           --              0           --
     Roddy, Katherine Tozer ..........           25            --           --              0           --
     Shah, Raju L ....................           25            --           --              0           --
     Tozer, Jr., W. James ............          200            --           --              0           --
Mayday Financing ($1.00 per share) ...                         --       Cl. B Pfd.          0           --
Accrued Interest / Notes Payable .....                      245,163         --        245,163           1.43%
Payables to be Converted .............                         --           --              0           --
AST Exchange Agent ...................                         --           --              0           --
** Aminoff, Cary .....................                         --       prof serv.     11,429           0.07%
Biotag Inc ...........................                         --           --         17,026           0.10%
BMA ..................................                         --           --              0           --
JMG Bonfrer ..........................                         --           --         10,000           0.06%
Boston Biomedical Research Institute .                         --           --         41,988           0.25%
Buttyan, Ralph .......................                         --           --          1,137           0.01%
Cede & Co ............................                         --           --        159,708           0.93%
Chandler, Joseph .....................                         --           --          2,273           0.01%
Charbit, Ingrid ......................                         --           --        100,000           0.58%
Clapp, David .......................                              0      mat. note    268,182           1.57%
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
Clapp Tte./Indian Creek Ptnrs ........                         --           --        161,391           0.94%
Codington, John F ....................                         --           --         27,917           0.16%
**Corsiglia, Robert J ................                         --           --        205,192           1.20%
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
Creative Biomolecules Inc ............                         --           --         22,565           0.13%
Daly, Daniel .........................                         --           --          4,268           0.02%
Deidrick, Aga B ......................                         --           --          8,000           0.05%
** Dr. Crawford ......................                         --           --         25,000           0.15%
** Dr. Brauer ........................                         --           --         25,000           0.15%
# Epigen Inc .........................                         --           --              0           --
Experta Treyhand AG ..................                         --           --         14,773           0.09%
Fawwaz, Rashid .......................                         --           --         18,868           0.11%
Field, Richard .......................                         --           --        200,000           1.17%
*Fresne, Donald C ....................                         --           --      5,972,104          34.89%
      Prefered Stock .................                         --        Cl. A Pfd.         0           --
     ##  Debt ........................                      314,992         --              0           --
Gelb, William ........................                         --           --          4,850           0.03%
Gelber, Cohava .......................                         --           --         10,000           0.06%
Goluboff, Eric .......................                         --           --          6,819           0.04%
Goldfrank, L .........................                         --           --        200,000           1.17%
Harley, Colin K ......................                         --           --         98,069           0.57%
Hilkens, John ........................                         --           --         10,000           0.06%
Hilton, Birgitt ......................                            0      25% note      37,500           0.22%
Hilton, Louis ........................                         --           --         13,637           0.08%
                                                               --           --              0           --
--                                                             --           --              0           --
Howard, Reese E ......................                         --           --          2,799           0.02%
                                                               --           --              0           --
--                                                             --           --              0           --
Johns, Marshall J & Marlene B ........                         --           --         29,546           0.17%
Kent, Richard E**** ..................                         --           --        433,462           2.53%
--                                                                0      25% note           0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
** Krane, Robert J ...................                         --           --        166,819           0.97%
Kuter, I .............................                         --           --          2,273           0.01%
Lawson, Carole .......................                         --           --         10,000           0.06%
Ledbetter Moore & Associates Inc .....                         --           --          2,273           0.01%
Levin, Bruce .........................                         --           --          1,313           0.01%
Liss, Irvine .........................                         --           --        100,000           0.58%
Long, Leo William ....................                         --        mat. note    544,603           3.18%
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
Martin E Janis & Company Inc .........                         --           --          2,534           0.01%
Mondschein, Lawrence .................                         --           --          8,183           0.05%
Mongiardo, James F ...................                         --           --        129,042           0.75%
Montgomery, Deborah ..................                         --           --          8,000           0.05%
Moore, Nancy K .......................                            0      25% note      75,000           0.44%
Nikrui, Najosam ......................                         --           --          3,410           0.02%
** Olsson, Carl ......................                         --           --        113,638           0.66%
Paulsen, D ...........................                         --           --          6,819           0.04%
Perisher Publishing ..................                         --           --         75,000           0.44%
Philadep & Co. .......................                         --           --              0           --
Potter, Ransel .......................                         --           --         21,685           0.13%
Rabinowitz, Jonathan D ...............                         --           --         30,125           0.18%
Rabinowitz, Joshua W .................                         --           --         30,125           0.18%
Rabinowitz, Peter D ..................                         --           --         30,125           0.18%
Rabinowitz, Rene S ...................                         --           --         30,125           0.18%
Rykowski, Emilia c/oRabinowitz .......                         --           --         30,125           0.18%
Rabinowitz, Rubin ....................                            0      25% note     328,051           1.92%
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
Richards & O'Neil LLP ................                         --           --          6,876           0.04%
Roberts, Paul ........................                         --           --          3,000           0.02%
Sandel Robert A ......................                            0      25% note     165,362           0.97%
Sandel Robert A  & Eleanor J .........                         --           --         49,993           0.29%
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
--                                                             --           --              0           --
Schroder, L Courtney .................                         --           --        145,396           0.85%
--                                                             --           --              0           --
--                                                             --           --              0           --
Schubach, Clark ......................                         --           --          1,516           0.01%
Smith. David H .......................                         --           --         17,787           0.10%
Somkey SA ............................                         --           --          1,273           0.01%
Sterman, Marshall ....................                         --           --          2,214           0.01%
--                                                             --           --              0           --
--                                                             --           --              0           --
Strategica Group Inc .................                         --           --          1,470           0.01%
The Mayflower Group Ltd ..............                         --           --         68,182           0.40%
** 'Tozer Jr., W. James (<9/1/98) ....                         --           --      1,699,725           9.93%
--                                                             --           --              0           --
--                                                             --           --              0           --
Tozer Jr., W. James (>9/1/98) ........                         --        Cl. A Pfd.   250,000           1.46%
--                                                             --           --              0           --
--                                                             --           --              0           --
Tozer Jr., W. James (>9/1/98) ........                            0      25% note      25,000           0.15%
Tozer Jr., W. James (IRA)c ...........                         --           --         11,819           0.07%
Vacold, LLC ..........................                         --           --        433,705           2.53%
Weil, Steven & Janet .................                         --           --         30,000           0.18%
--                                                             --           --              0           --
--                                                             --           --              0           --
Westheimer, J. & A ...................                         --           --         37,500           0.22%
--                                                             --           --              0           --
--                                                             --           --              0           --
Westheimer, Laura ....................                         --           --         37,500           0.22%
--                                                             --           --              0           --
--                                                             --           --              0           --
Zahav Ltd ............................                         --           --         30,304           0.18%
Shareholders with less than1000 Shares                         --           --         22,203           0.13%
Variance: AST Exhange Variance .......

                                                         ----------                ---------          ------
*TOTAL ...............................                      560,155                17,115,439         100.00%
                                                          =========                ==========         ======


# The 12/31/99 Financials show that Epigen holds in treasury 5 shares, while the American Stock Transfer (AST) 12/31/99 shows 25,795
old shares registered to Epigen which would convert into 1,173 new shares in treasury.
Epigen's Board is taking action to retire all treasury shares and to confirm Epigen's common shares outstanding as of 12/31/99 being
equal to AST's records less the shares currently registered in Epigen's name which are being retired.


**Commitments to Issue Common Stock
Aminoff, Cary A.             $29,800 for 'Preparation of Business Plans
Robert J. Corsiglia          Shares to be issued to reflect an appropriate conversion rate of $.83 vs $2.66 on previously converted
                             notes.
Dr. Crawford                 Completion of lung cancer IRB for COD Test
Dr. Brauer                   Consulting Services
Olsson, Carl                 Consulting Services
Krane, R.                    Execution of definitive liscense agreement with strategic partner
Fresne, Donald               Perpetual 33 1/3% anti-dilution protection
Tozer, W. James Jr.          10% anti-dilution protection on 750,552 shares until definitive license agreement with strategic
                             partner

****By agreement Kent to receive $3000 per month in salary and 37000 option at $0.50 on June 1st of each year.
</TABLE>

                                      -25-


<PAGE>

                                    EXHIBIT B


                                      Number of Shares                  Amount
Name of Shareholder                   of Common Stock   Purchase Price  Invested
-------------------                   ---------------   --------------  --------

Farran Tozer Brown ...............        106,975       $   1,069.75    $ 25,000

David Clapp ......................        855,800           8,558.00     200,000

Robert J. Corsiglia ..............        106,975           1,069.75      25,000

Richard D. Field .................        427,900           4,279.00     100,000

Donald C. Fresne .................        213,950           2,139.50      50,000

Lionel Goldfrank III .............        641,850           6,418.50     150,000

Christy Parsons ..................        513,480           5,134.80     120,000

Katherine Tozer Roddy ............        106,975           1,069.75      25,000

Raju L. Shah .....................        106,975           1,069.75      25,000

W. James Tozer, Jr ...............        855,800           8,558.75     200,000



                                      -26-


<PAGE>


                                    EXHIBIT C


                                                   Number of Shares    Purchase
Name of Shareholder                                of Common Stock      Price
-------------------                                ----------------    ---------

Farran Tozer Brown .......................             50,000           $ 25,000

David Clapp ..............................            400,000            200,000

Robert J. Corsiglia ......................             50,000             25,000

Richard D. Field .........................            200,000            100,000

Donald C. Fresne .........................            100,000             50,000

Lionel Goldfrank III .....................            300,000            150,000

Christy Parsons ..........................            240,000            120,000

Katherine Tozer Roddy ....................             50,000             25,000

Raju L. Shah .............................             50,000             25,000

W. James Tozer, Jr .......................            400,000            200,000

                                      -27-

<PAGE>

                                    EXHIBIT D


                           CERTIFICATE OF AMENDMENT OF

                       DESIGNATION, PREFERENCES AND RIGHTS

                                       OF

                            SERIES B PREFERRED STOCK

                                       OF

                                  EPIGEN, INC.


         EPIGEN,  INC., a corporation  organized and existing  under the laws of
the State of Delaware (the  "Corporation),  in accordance with the provisions of
Section 151 of the General Corporation Law of the State of Delaware, does hereby
CERTIFY:

         1. The  Certificate of  Incorporation,  as amended,  of the Corporation
fixes the total  number of shares of all  classes  of  capital  stock  which the
Corporation  shall have  authority to issue as Sixty-Five  Million  (65,000,000)
shares,  of which Fifty Million  (50,000,000)  shares shall be Common Stock, par
value $.001 per share (the "Common  Stock"),  and Fifteen  Million  (15,000,000)
shares  shall be shares of  Preferred  Stock,  par  value  $.001 per share  (the
"Preferred Stock").

         2. The Certificate of  Incorporation,  as amended,  of the Corporation,
expressly  grants to the Board of  Directors  of the  Corporation  authority  to
provide for the issuance of said  Preferred  Stock in one or more  series,  with
such  voting  powers,  and with such  designations,  preferences  and  relative,
participating, optional or other special rights, and qualifications, limitations
or restrictions  thereof,  as shall be stated and expressed in the resolution or
resolutions providing for the issue thereof adopted by the Board of Directors as
are not stated and expressed in its Certificate of Incorporation, as amended.

         3. Pursuant to authority  conferred  upon the Board of Directors by the
Certificate of Incorporation,  as amended, the Board of Directors,  at a meeting
duly  held on June 17,  1996,  at which a quorum  was duly  present  and  acting
throughout,  duly authorized and adopted the provisions  establishing a Series B
Preferred  Stock of the  Corporation  pursuant to a Certificate of  Designation,
Preferences  and Rights of Series B Preferred  Stock filed with the Secretary of
State of Delaware on June 18, 1996.  All of the  outstanding  shares of Series B
Preferred  Stock were  acquired  by the  Corporation  pursuant to an exchange of
shares of its Common  Stock for such  outstanding  shares of Series B  Preferred
Stock on July 14, 1997 and  restored to the status of  authorized  but  unissued
shares of preferred stock, without designation.  Pursuant to authority conferred
upon the Board of Directors by the Certificate of Incorporation, as amended, the
Board of  Directors,  at a meeting duly held on June 7, 2000,  at which a quorum
was duly  present  and  acting  throughout,  duly  authorized  and  adopted  the
provisions set forth in the following

                                      -28-

<PAGE>

resolution providing for an Amended Certificate of Designation,  Preferences and
Rights of Series B Preferred Stock as follows:

         RESOLVED,  that an issue of a series of the Preferred  Stock, par value
$.001  per  share,  of the  Corporation  consisting  of  Five  Hundred  Thousand
(500,000)  shares is hereby  provided  for, and the voting  power,  designation,
preferences and relative,  participating,  optional or other special rights, and
the  qualifications,  limitations or restrictions  thereof,  are fixed hereby as
follows:

                  1.  DESIGNATION.  The  designation  of such  series  shall  be
         "Series B Preferred  Stock"  (hereinafter  referred to as the "Series B
         Preferred Stock") and the number of shares  constituting such series is
         Five Hundred  Thousand  (500,000).  The number of authorized  shares of
         Series B  Preferred  stock  may be  increased  or  reduced  by  further
         resolutions  of the board of Directors of the  Corporation  or any duly
         authorized  committee  thereof  and  by  the  filing  of a  certificate
         pursuant to the provisions of the General  Corporation Law of the State
         of  Delaware  stating  that  such  increase  or  reduction  has been so
         authorized,  but the number of shares of Series B Preferred Stock shall
         not be reduced  below  500,000  unless there shall be less than 500,000
         shares of  Series B  Preferred  Stock  outstanding,  in which  case the
         number of shares of Series B Preferred Stock may be reduced to a number
         of shares equal to the number of such shares  outstanding  from time to
         time.  Shares  of  Series  B  Preferred  Stock  shall be  evidenced  by
         certificates registered in the name of the record holder of such shares
         of Series B Preferred Stock.

                  2.  DIVIDENDS.  The Series B Preferred Stock shall be entitled
         to share pari passu on a share for share basis with the Common Stock of
         the  Corporation  if, in any  dividends if, as and when declared by the
         Corporation's Board of Directors.

                  3.  MANDATORY  REDEMPTION.  The  shares of Series B  Preferred
         Stock shall be redeemed  by the  Corporation  not later than August 31,
         2001 (the "Redemption  Date") at a price per share of $1.00;  provided,
         however, that the Corporation shall have the right at any time prior to
         the  Redemption  Date to  repurchase  all or any  portion  of the  then
         outstanding  shares of Series B  Preferred  Stock,  pro rata,  from the
         holders thereof providing it has funds legally available therefor.  Any
         such repurchase shall be upon thirty (30) days' prior written notice to
         the holders of the shares of Series B  Preferred  Stock,  which  notice
         shall set forth the number of shares of Series B Preferred  Stock to be
         repurchased  from the holder  receiving  such notice,  the date of such
         repurchase (the  "Repurchase  Date"),  and  instructions  for tendering
         certificates  representing the shares of Series B Preferred Stock to be
         repurchased.  From and after any Repurchase Date, the holders of shares
         of Series B Preferred shall have no rights as shareholders with respect
         to the shares of Series B Preferred Stock so purchased, but shall stand
         as creditors of the Corporation for the amount of the repurchase  price
         therefor.

                  4.  SHARES TO BE  RETIRED.  All  shares of Series B  Preferred
         Stock  redeemed or  purchased by the  Corporation  shall be retired and
         canceled and shall be restored to the status of authorized but unissued
         shares of Preferred Stock,  without  designation as to series,  and may
         thereafter be issued, but not as shares of Series B Preferred Stock.

                                      -29-

<PAGE>

                  5.  CONVERSION OR EXCHANGE.

                  (a) CONVERSION  RIGHT.  Except as set forth in subsection 5(c)
         hereof, at any time prior to the Mandatory Redemption Date set forth in
         Section 3 hereof,  the holders of Series B  Preferred  Stock shall have
         the right at any time to convert  all,  but not less than all,  of such
         shares of Series B  Preferred  Stock into  shares of the  Corporation's
         Common  Stock or such other  securities  into which such  Common  Stock
         shall have been converted,  or by which the Corporation's  Common Stock
         shall have been  replaced,  at the rate of one share of Common Stock of
         the Corporation for each share of Series B Preferred Stock.

                  (b) MANDATORY  CONVERSION.  In the event the Corporation shall
         engage  in  an  "equity   financing"  for  Common  Stock  and/or  other
         securities of the Corporation then each  outstanding  share of Series B
         Preferred  Stock must be converted by the holders of Series B Preferred
         Stock into Common Stock and/or other  securities of the  Corporation at
         one of the following rates: (i) the amount of shares of Common Stock or
         other securities of the Corporation set forth in Section 5(a) hereof or
         (ii) that number of shares of Common Stock and/or other  securities  of
         the  Corporation to be offered in such equity  financing  determined by
         (A) dividing the aggregate  purchase  price paid by such holder for his
         or her shares of Series B  Preferred  Stock by the  aggregate  purchase
         price paid by the  purchasers of the  Corporation's  securities in such
         equity  financing and (B)  multiplying  the  resulting  quotient by the
         number of  shares  of  Common  Stock  and/or  other  securities  of the
         Corporation to be issued in such equity financing. For purposes of this
         provision, the term "equity financing" shall mean the sale the sale, in
         one or more  transactions or offerings by the Corporation of its shares
         of Common Stock and/or other  securities  resulting in aggregate  gross
         proceeds to the Corporation of not less than  $2,000,000.  In the event
         the equity financing shall involve  transactions  with different terms,
         any election by a holder of Series B Preferred  Stock to convert his or
         her shares Series B Preferred Stock pursuant to subsection (ii) of this
         Section  5(b)  shall  be  pro  rata  among  the  various   transactions
         constituting the equity financing.

                  (c) NOTICE OF CONVERSION.  Any holder of outstanding shares of
         Series B Preferred  Stock may elect to convert  such shares of Series B
         Preferred  Stock into shares of Common Stock by serving  written notice
         on the  Corporation  setting  forth  (1) the  number  of shares of such
         holder's  Series B  Preferred  Stock to be  converted;  (2) the date by
         which such conversion must occur,  such date being at least twenty (20)
         and not more  than  sixty  (60)  days  after  the date of such  notice;
         provided, however, that in the event the Company exercises its right to
         redeem the Series B Preferred  Stock prior to the Mandatory  Redemption
         Date set forth in Section 3 hereof,  the  holders of Series B Preferred
         Stock shall have the right to elect to convert pursuant to Section 5(a)
         hereof  at any time  prior to such  early  redemption  date by  written
         notice to that effect received by the Corporation prior to the date set
         forth in the Corporation's notice of early redemption; (3) whether such
         shares of Common  Stock or other  securities  are to be  evidenced by a
         single  certificate or multiple  certificates (in which latter case the
         denominations of such certificates shall also be set forth); and (4) if
         such certificates are to be issued in the name

                                      -30-

<PAGE>

         or names of a person or  persons  other  than that of the holder of the
         Series B Preferred Stock so converting,  the name(s) and address(es) of
         such other person(s). Any securities issued pursuant to this subsection
         (b)(ii) shall be in addition to any securities  actually issued in such
         equity financing.

                  (d) ISSUANCE OF CERTIFICATES. Promptly following the effective
         date  of  any  conversion  in  accordance  with  this  Section  5,  the
         Corporation shall issue a certificate or certificates evidencing shares
         of Common Stock and/or other  securities of the Corporation  into which
         such  shares  of  Series B  Preferred  Stock  have  been  converted  in
         accordance with this Section 5.

                  6.  CERTAIN ADJUSTMENTS.

                  (a) STOCK DIVIDENDS,  SPLITS AND COMBINATIONS.  If at any time
         or from time to time,  the holders of Common Stock  become  entitled to
         receive  additional  shares or less shares because of a stock dividend,
         stock split or combination of shares,  the number of outstanding shares
         of   Series   B   Preferred   Stock   shall  be   proportionately   and
         correspondingly adjusted.

                  (b)  RECLASSIFICATIONS.  If at any time or from  time to time,
         the  holders of Common  Stock  become  entitled  to receive a different
         class of stock (the  "Entitlement  Event"),  any holder of  outstanding
         shares of Series B  Preferred  Stock  shall be  entitled to receive the
         same  number  and kind of  shares of stock as a holder of shares of the
         Common Stock immediately prior to the Entitlement Event was eligible to
         receive with respect to such Common Stock  pursuant to the  Entitlement
         Event. This provision shall include any  reclassification in connection
         with a merger of another corporation into the Corporation.

                  (c) MERGER INTO OR SALE OF ASSETS TO ANOTHER  CORPORATION.  If
         at any time or from  time to time,  the  holders  of the  Common  Stock
         become entitled to receive stock, securities,  property or cash (or any
         combination  of  them)  by  reason  of  a  capital   reorganization  or
         dissolution,  liquidation  or winding-up of the  Corporation,  a merger
         with,  a  consolidation  of the  Corporation  into,  a  sale  of all or
         substantially  all  of  the  assets  of  the  Corporation  to,  another
         corporation  (the  "Reorganization  Event"),  each  holder of shares of
         Series B  Preferred  Stock shall be entitled to receive the same stock,
         securities,  property or cash (or  combination  of them) as a holder of
         the same number of shares of the Common  Stock was  eligible to receive
         with respect to such Common Stock pursuant to the Reorganization Event.

                  7. VOTING RIGHTS.  The holders of shares of Series B Preferred
         Stock shall be  entitled,  at all meetings of the  Stockholders  of the
         Corporation  and on all occasions  where  stockholders  are entitled to
         vote or give their consent,  to one (1) vote for each share of Series B
         Preferred  Stock  owned by them.  The  holders  of  shares  of Series B
         Preferred  Stock shall vote with the holders of shares of Common  Stock
         as a single class on all matters,  except to the extent that holders of
         Common  Stock or holders of Series B Preferred  Stock shall be entitled
         to vote as a

                                      -31-

<PAGE>

         separate class only on matters which effect the rights, preferences and
         privileges of the Series B Preferred Stock.

                  8.  LIQUIDATION  PREFERENCE.  In the event of any voluntary or
         involuntary liquidation,  dissolution or winding up of the Corporation,
         the  holders  of the  Series B  Preferred  Stock  shall  entitled  to a
         liquidation preference of $1.00 per share, payable out of the assets of
         the  Corporation  therefor  prior to any  payment to the holders of the
         Corporation's  Series A Preferred  Stock of Common Stock.  In the event
         the assets of the  Corporation are not sufficient to pay such amount in
         full,  the  assets  legally  available  therefor  shall  be paid to the
         holders of Series B Preferred  Stock,  pro rata. The  consolidation  or
         merger of the Corporation  with or into any other  corporation,  or the
         sale  of  substantially  all  of  the  assets  of  the  Corporation  in
         consideration   for  the  issuance  of  equity  securities  of  another
         corporation,  shall not be regarded as a  liquidation,  dissolution  or
         winding up of the Corporation within the meaning of this Section 7, but
         only if such  consolidation,  merger or sale of assets shall not in any
         way impair  the  voting  power,  preferences  or special  rights of the
         Series B Preferred Stock.

                  9.  LIMITATIONS ON DIVIDENDS ON JUNION RANKING STOCK.  So long
         as any Series B Preferred Stock shall be  outstanding,  the Corporation
         shall not declare any  dividends on the Common Stock or any other stock
         of the Corporation  ranking as to dividends or  distributions of assets
         junior to the Series B Preferred  Stock (any such junior  ranking stock
         being  herein  referred to as "Junior  Stock"),  or make any payment on
         account of, or set apart money for, a sinking or other  analogous  fund
         for the  purchase,  redemption  or other  retirement  of any  shares of
         Junior Stock, or make any distribution in respect  thereof,  whether in
         cash or property or in obligations or stock of the  Corporation,  other
         than  Junior  Stock  (such  dividends,   payments,  setting  apart  and
         distributions being herein called "Junior Stock Payments"),  unless the
         Corporation  shall not be in default or in arrears  with respect to any
         sinking or other  analogous fund or any call for tenders  obligation or
         other agreement for the purchase, redemption or other retirement of any
         shares of Preferred Stock other than Junior Stock. For purposes of this
         Section 9, the  Corporation's  Series A Preferred Stock shall be deemed
         Junior Stock.

                  10. RESTRICTIONS ON TRANSFER.

                  (a)  RESTRICTIONS ON TRANSFER.  Neither the Series B Preferred
         Stock, nor any interest therein,  shall be transferable except upon the
         conditions  specified in this Section 10, which conditions are intended
         to ensure  compliance  with the Securities Act of 1933, as amended (the
         "Securities  Act") and all applicable  state securities laws in respect
         of the transfer of any such securities or any interest therein.

                  (b) RESTRICTIVE LEGEND. Each certificate,  if shares of Series
         B Preferred  Stock shall issued in  certificated  form,  shall  (unless
         otherwise  permitted  by the  provisions  of this Section 10) include a
         legend in a form similar to the following:

                                      -32-

<PAGE>

                  NEITHER THE SECURITIES REPRESENTED BY THIS CERTIFICATE NOR THE
         SECURITIES INTO WHICH THEY ARE CONVERTIBLE  HAVE BEEN REGISTERED  UNDER
         THE SECURITIES ACT OF 1933, AS AMENDED,  AND NEITHER SUCH SECURITIES NO
         ANY  INTEREST  THEREIN MAY BE SOLD,  TRANSFERRED,  PLEDGED OR OTHERWISE
         DISPOSED OF IN THE ABSENCE OF  REGISTRATION  OR AN EXEMPTION  THEREFROM
         UNDER  SUCH ACT,  APPLICABLE  STATE  SECURITIES  LAWS AND THE RULES AND
         REGULATIONS THEREUNDER.

                  (c)  NOTICE OF  PROPOSED  TRANSFER.  Each  holder of shares of
         Series B Preferred  Stock, by his acceptance of such shares,  agrees to
         comply in all respects with the provisions of this Section 10. Prior to
         any proposed transfer of any shares of Series B Preferred Stock, except
         in the case of registration  thereof  pursuant to the Securities Act of
         1933, as amended,  the holder  thereof shall give written notice to the
         Corporation of such holder's  intention of effect such  transfer.  Each
         such  notice  shall  describe  the  manner  and  circumstances  of such
         transfer  in  reasonable  detail,  and  shall be  accompanied  by (i) a
         written opinion of counsel reasonable  satisfactory to the Corporation,
         addressed to the Corporation,  to the effect that the proposed transfer
         may be effected  without  registration of the Series B Preferred Stock,
         or (ii)  written  assurance  from the  Securities  Exchange  Commission
         ("SEC")  that the SEC will not  recommend  any action be taken by it in
         the event such  transfer is effected  without  registration  under such
         Act.  Such proposed  transfer may be effected  only if the  Corporation
         shall have  received such notice and such opinion of counsel or written
         assurance,  whereupon  the holder of such  shares of Series B Preferred
         Stock shall be  entitled to transfer  such shares of Series B Preferred
         Stock in  accordance  with the terms of such notice.  Each  certificate
         evidencing shares of Series B Preferred Stock so transferred shall bear
         the legend set forth in Section 10(b) hereof,  and each  uncertificated
         share of Series B Preferred  Stock so  transferred  shall have  entered
         against it in the Corporation's  stock transfer ledger or other similar
         records a "stop transfer" legend, except that either such legend may be
         removed  if the  opinion of  counsel  or  written  assurance  is to the
         further effect that no such legend nor the  restrictions on transfer in
         this  Section 10 are required in order to ensure  compliance  with such
         Act.

                  11.  PREEMPTIVE  RIGHTS.  The  holders  of  shares of Series B
         Preferred Stock shall not be entitled to any preemptive or preferential
         rights for the  subscription  to any shares of any capital stock of the
         Corporation.

         IN WITNESS  WHEREOF,  the Corporation has caused this Certificate to be
signed by Donald C.  Fresne,  its  President,  who affirms,  under  penalties of
perjury,  that this  Certificate is the act and deed of the Corporation and that
the facts stated herein are true, as of the 7th th day of June, 2000.

                                       EPIGEN, INC.

                                       By: /s/ Donald C. Fresne
                                           --------------------
                                       Name: Donald C. Fresne
                                       Title: President

                                      -33-

<PAGE>

                                    EXHIBIT E


                                 PROMISSORY NOTE

U.S.$356,213.63                                               Date: June 7, 2000


         FOR VALUE RECEIVED,  Epigen, Inc., a Delaware corporation ("Borrower"),
hereby  promises  to pay to Donald C.  Fresne,  with an address at Tower  Lodge,
North Tower Hill Road, Box L, Millbrook,  NY 12545 ("Holder"),  or at such other
location as Holder  shall  specify in a written  notice to  Borrower,  in lawful
money of the United  States of America,  in  immediately  available  funds,  the
principal sum of U.S. Three Hundred Fifty-Six  Thousand Two Hundred Thirteen and
63/100  Dollars  (U.S.  $356,213.63),  together  with  interest on the principal
amount from time to time outstanding at the annual rate of nine percent (9%) per
annum.  Of the original  principal  amount of this Note,  the sum of $156,213.63
shall be paid by Borrower to Holder in three equal annual installments beginning
on  June 1,  2001,  together  with  interest  accrued  on the  principal  amount
outstanding  from time to time. Of the original  principal  amount of this Note,
the sum of $200,000  shall be payable by Borrower on demand by Holder,  together
with any accrued but unpaid interest hereunder.

         The  principal  balance of this Note may be prepaid by  Borrower at any
time, without premium or penalty.

         The sum of  $200,000  principal  amount of this note is  secured by the
grant of a security  interest  to Holder by Borrower  pursuant  to that  certain
Preferred Stock and Warrant  Purchase and Security  Agreement dated as of May 1,
1995 between Borrower and Holder.

         Presentation,  demand, protest and notice of dishonor are hereby waived
by the  undersigned.  No delay or  omission by Holder in  exercising  its rights
under this Note shall operate as a waiver of such rights, nor shall the exercise
of any right with respect to this Note waive or preclude  the later  exercise of
such right or any other right.

         Borrower promises to pay all costs and out-of-pocket expenses of Holder
in obtaining performance under this Note, including fees and expenses of counsel
for Holder. Borrower agrees to pay principal, interest and all other amounts due
under this Note without setoff, counterclaim or any deduction whatsoever.

         Delivery of any notice  required or  permitted  to be sent  pursuant to
this  Note  shall be deemed  to have  occurred  when  actually  received  by the
intended  recipient.  Any notice sent hereunder shall be sent by certified mail,
return receipt requested,  Express Mail or by a nationally  recognized overnight
courier  service.  For purposes of this Note,  the term "Business Day" means any
day  other  than a day on  which  banks  located  in the  State  of New York are
required or permitted to close.

                                      -34-

<PAGE>

         This Note shall be governed by and  construed  in  accordance  with the
laws of the State of New York.

                                       EPIGEN, INC.


                                       By:/s/ Donald C. Fresne
                                           -------------------
                                       Name: Donald C. Fresne
                                       Title: Chairman, President and
                                       Chief Executive Officer

                                      -35-

<PAGE>

                                    EXHIBIT F


                                 PROMISSORY NOTE

U.S.$ $156,213.63                                             Date: June 7, 2000


         FOR VALUE RECEIVED,  Donald C. Fresne,  with an address at Tower Lodge,
North Tower Hill Road, Box L, Millbrook, NY 12545 ("Borrower"),  hereby promises
to pay to Epigen,  Inc., a Delaware  corporation with an address at Tower Lodge,
North Tower Hill Road, Box L, Millbrook,  NY 12545 ("Holder"),  or at such other
location as Holder  shall  specify in a written  notice to  Borrower,  in lawful
money of the United  States of America,  in  immediately  available  funds,  the
principal sum of U.S. One Hundred  Fifty-Six  Thousand Two Hundred  Thirteen and
63/100 Dollars (U.S.$156,213.63), together with interest on the principal amount
from time to time outstanding at the annual rate of nine percent (9%) per annum.
Such  principal and accrued  interest shall be repaid in  installments  equal in
amount to the  installment  payments of principal and interest to be received by
Borrower from Holder  pursuant to that certain  Primissory  note in the original
principal  amount  of  $356,213.63,  dated  June 7,  2000,  if, as and when such
installments are received by Borrower.

         The  principal  balance of this Note may be prepaid by  Borrower at any
time, without premium or penalty.

         Presentation,  demand, protest and notice of dishonor are hereby waived
by the  undersigned.  No delay or  omission by Holder in  exercising  its rights
under this Note shall operate as a waiver of such rights, nor shall the exercise
of any right with respect to this Note waive or preclude  the later  exercise of
such right or any other right.

         Borrower promises to pay all costs and out-of-pocket expenses of Holder
in obtaining performance under this Note, including fees and expenses of counsel
for Holder. Borrower agrees to pay principal, interest and all other amounts due
under this Note without setoff, counterclaim or any deduction whatsoever.

         Delivery of any notice  required or  permitted  to be sent  pursuant to
this  Note  shall be deemed  to have  occurred  when  actually  received  by the
intended  recipient.  Any notice sent hereunder shall be sent by certified mail,
return receipt requested,  Express Mail or by a nationally  recognized overnight
courier  service.  For purposes of this Note,  the term "Business Day" means any
day  other  than a day on  which  banks  located  in the  State  of New York are
required or permitted to close.

                                      -36-

<PAGE>

         This Note shall be governed by and  construed  in  accordance  with the
laws of the State of New York.

                                       /s/ Donald C. Fresne
                                       --------------------
                                       Donald C. Fresne

                                      -37-

<PAGE>

                                    EXHIBIT G


Holders of 2% or more of Epigen Common Stock.

<TABLE>

Clapp, David
Indian Creek Partners, LP
Summary of Investments & Holdings in Epigen, Inc. & Biofund, Inc.

<CAPTION>
Investment Date ................................    07/07/97    12/23/97    07/29/98       n/a      02/23/99    11/12/99     Totals
                                                    --------    --------    --------    --------    --------    --------    --------
<S>                                                 <C>         <C>         <C>         <C>         <C>         <C>         <C>
Amount .........................................    $100,000        --      $100,000        --      $ 50,000        --      $250,000
Loan Amount ....................................        --      $100,000        --          --          --          --      $100,000
Terms of Promissory Note .......................        --      Prime+5%        --          --          --          --          --
Maturity Date ..................................        --      12/23/98        --          --          --          --          --
Shares Purchases ...............................      36,363        --       120,482        --        50,000        --       206,845
Price Per Share ................................    $   2.75        --      $   0.83        --      $   1.00        --          --
Available Conversion ...........................        --        37,594        --          --          --          --          --
Class C Warrants ...............................       9,091        --          --          --          --          --         9,091
Price Per Share ................................    $   2.00        --          --          --          --          --          --
Expiration Date ................................    12/31/01        --          --          --          --          --          --
Class D Warrants ...............................       9,091        --          --          --          --          --         9,091
Price Per Share ................................    $   2.00        --          --          --          --          --          --
Expiration Date ................................    12/31/01        --          --          --          --          --          --
Escrow Agreement Date ..........................        --          --          --      12/23/97        --          --          --
Escrow Agreement w/D. Fresne ...................        --          --          --       160,000        --          --       160,000
Escrow Agent Certificate Number ................        --          --          --      CS3066          --          --          --
Price Per Share ................................        --          --          --      $   2.66        --          --          --
Expiration Date ................................        --          --          --      12/28/02        --          --          --
Series F Warrants ..............................        --          --          --          --        50,000        --        50,000
Price Per Share ................................        --          --          --          --      $   1.50        --          --
Expiration Date ................................        --          --          --          --      03/31/04        --          --
Series G Warrants ..............................        --          --          --          --        50,000        --        50,000
Price Per Share ................................        --          --          --          --      $   2.00        --          --
Expiration Date ................................        --          --          --          --      03/31/04        --          --
Biofund, Inc. CD Collateral Loan ...............        --          --          --          --          --      $200,000    $200,000
Biofund, Inc. Shares Owned .....................        --          --          --          --          --           200         200

Summary
-------
Epigen, Inc.
  Total Investment                                    $350,000
  Common Shares Purchased                              206,845
  Exercisable Warrants & Options                       278,182
Biofund, Inc.
  Total Investment                                    $200,000
  Shares Owned                                             200

</TABLE>
<PAGE>

<TABLE>

Corsiglia, Robert
Summary of Investments & Holdings in Epigen, Inc. & Biofund, Inc.

<CAPTION>
Investment Date .................   08/11/95   12/18/96    10/10/97        01/16/98      07/02/98
                                    --------   --------    --------        --------      --------
<S>                                <C>        <C>        <C>             <C>             <C>
Amount .........................   $ 25,000   $100,000   Equity Kicker   Equity Kicker   $ 25,000
Common Shares Issued ............      4,545     36,364          12,500           9,399     30,121
Price Per Share .................   $   5.50   $   2.75            --              --     $   0.83
Warrant .........................      4,545       --              --              --         --
Strike Price ....................   $   2.00       --              --              --         --
Expiration Date .................   09/01/00       --              --              --         --
Warrant .........................       --         --              --            18,997       --
Strike Price ....................       --         --              --     $        2.66       --
Expiration Date .................       --         --              --        01/16/03         --
Class C Warrants ................       --        9,091            --              --         --
Strike Price ....................       --     $   2.00            --              --         --
Expiration Date .................       --     12/31/01            --              --         --
Class D Warrants ................       --        9,091            --              --         --
Strike Price ....................       --     $   2.00            --              --         --
Expiration Date .................       --     12/31/01            --              --         --
 Biofund, Inc. CD Collateral Loan       --         --              --              --         --
Biofund, Inc. Shares Owned ......       --         --              --              --         --

<CAPTION>
Investment Date .................     09/17/98       11/18/99      03/13/00         Totals
                                      --------       --------      --------         ------
<S>                                <C>               <C>        <C>                <C>
Amount .........................   Debt to Equity        --     Debt to Equity     $150,000
Common Shares Issued ............           22,010       --          48,527         163,466
Price Per Share .................   $         0.83       --     $         0.83         --
Warrant .........................             --         --            --              --
Strike Price ....................             --         --       Conversion           --
Expiration Date .................             --         --        Rate of             --
Warrant .........................             --         --       09/17/1999         55,417
Strike Price ....................             --         --        Changed             --
Expiration Date .................             --         --       From $2.66           --
Class C Warrants ................             --         --        to $.83.           9,091
Strike Price ....................             --         --       (See Board           --
Expiration Date .................             --         --       Minutes of           --
Class D Warrants ................             --         --       1/21/00.)           9,091
Strike Price ....................             --         --            --              --
Expiration Date .................             --         --            --              --
 Biofund, Inc. CD Collateral Loan             --     $ 25,000          --          $ 25,000
Biofund, Inc. Shares Owned ......             --           25          --                25

</TABLE>
<PAGE>

Field, Richard D.
Summary of Investments & Holdings in Epigen, Inc. & Biofund, Inc.

Investment Date .........................     07/27/99     11/18/99      Totals
                                              --------     --------     --------
Amount .................................      $100,000         --       $100,000
Common Shares Purchased ................       100,000         --        100,000
Price Per Share ........................      $   1.00         --           --
Series H Warrant .......................       100,000         --        100,000
Strike Price Per Share .................      $   3.00         --           --
Expiration Date .........................     06/30/04         --           --
Biofund, Inc. CD Collateral Loan .......          --       $100,000     $100,000
Biofund, Inc. Shares Owned ..............         --            100          100

<PAGE>

Fresne, Donald C.
Summary of Investments & Holdings in Epigen, Inc. & Biotag, Inc.

Date .............................     At 12/31/99    At 12/31/00       Totals
                                       -----------    -----------     ----------
Considertion (approximate) .......     $4,000,000         --          $4,000,000
Common Shares Issued .............      2,260,325         --           2,260,325
Assuming Series A Conversion .....        600,000         --             600,000
Warrants .........................         24,702        1,000            25,702
Strike Price .....................     $     0.83       $ 2.66             --
Expiration Date ..................       04/15/03       12/31/02           --

Biotag, Inc. Shares ..............         17,026         --              17,026

<PAGE>

Goldfrank, III, Lionel
Summary of Investments & Holdings in Epigen, Inc. & Biofund, Inc.

Investment Date .........................     06/24/99     11/30/99      Totals
                                              --------     --------     --------
Amount .................................      $100,000         --       $100,000
Common Shares Purchased ................       100,000         --        100,000
Price Per Share ........................      $   1.00         --           --
Series H Warrant .......................       100,000         --        100,000
Price Per Share ........................      $   3.00         --           --
Expiration Date .........................     06/30/04         --           --
Biofund, Inc. CD Collateral Loan ........         --        150,000     $150,000
Biofund, Inc. Shares Owned ..............         --            150          150

<PAGE>

<TABLE>

Kent, Richard E.
Summary of Investments & Holdings in Epigen, Inc.

<CAPTION>
Date .................   07/14/97  09/25/97   At 12/31/99    At 12/31/99   At 12/31/99   At 12/31/99
                         --------  --------   -----------    -----------   -----------   -----------
<S>                      <C>       <C>        <C>            <C>           <C>           <C>
Debt Conversion Amount   $45,307      --           --             --            --            --
Conversion Rate ......   $ 0.095      --      (Bonus/Svcs)        --            --            --
Shares Issued ........    21,678    12,500      143,411           --            --            --
Amount ...............      --     $25,000         --             --            --            --
Promissory Note Issued      --          25%        --             --            --            --
Maturity Date ........      --     10/06/98        --             --            --            --
Options ..............      --        --           --            2,136         1,931         1,681
Strike Price .........      --        --           --           $ 2.00        $ 2.00        $ 2.00
Expiration Date ......      --        --           --          09/13/01      03/25/02      06/01/02


<CAPTION>
Date .................   At 12/31/99   At 12/31/99   At 12/31/99   At 12/31/99   At 12/31/99   At 12/31/99     Totals
                         -----------   -----------   -----------   -----------   -----------   -----------   --------
<S>                      <C>           <C>           <C>           <C>           <C>           <C>         <C>
Debt Conversion Amount        --            --            --            --            --            --     $ 45,307
Conversion Rate ......        --            --            --            --            --            --         --
Shares Issued ........        --            --            --            --            --            --      177,589
Amount ...............        --            --            --            --            --            --     $ 25,000
Promissory Note Issued        --            --            --            --            --            --         --
Maturity Date ........        --            --            --            --            --            --         --
Options ..............         401         1,681         1,681         1,681         1,681        47,000     59,873
Strike Price .........      $ 2.00        $ 2.00        $ 2.00        $ 2.00        $ 2.00        $ 0.50       --
Expiration Date ......     12/02/02      06/01/03      06/01/04      06/01/05      06/01/06      11/01/06      --

</TABLE>

<PAGE>

Long, Leo William
Summary of Holdings

Investments
-----------
  11/10/95                                 $ 100,000
  01/01/96                                   200,000
  05/24/96                                    50,000
  08/20/96                                    50,000
  02/01/97                                   100,000
  01/21/98                                   100,000
  02/26/99                                    50,000
                                      ---------------
    Total Investment                       $ 650,000

Shares of Common Stock                       177,273

Warrants                                                Exp Date
--------                                                --------
  $2.00 strike price                          18,182    11/30/00
  $2.00 strike price                          36,364    01/31/01
  $2.66 strike price                          75,188    01/21/03
  Class C, $2.00 strike price                 18,182    06/30/01
  Class D, $2.00 strike price                 18,182    06/30/01
  Series F, $1.50 strike price                50,000    03/31/04
  Series G, $2.00 strike price                50,000    03/31/04
                                      ---------------
    Total Warrants                           266,098

Promissory Note
---------------
  Rate:  Prime + 5%                        $ 100,000
  (Included in the $650,000
   investment.)

<PAGE>

Parsons, Christy
Summary of Investments & Holdings in Biofund, Inc.

Investment Date ................................        04/13/00         Totals
                                                        --------        --------
Biofund, Inc. CD Collateral Loan ...............        $120,000        $120,000
Biofund, Inc. Shares Owned .....................             120             120

<PAGE>

<TABLE>

Tozer, Jr., W. James
Summary of Investments & Holdings in Epigen, Inc. & Biofund, Inc.

<CAPTION>
Investment Date ................   08/18/95   07/14/97    10/17/97    04/28/98
                                   --------   --------    --------    --------
<S>                                <C>       <C>          <C>         <C>
Amount ........................   $ 25,000      --           --      $100,000
Loan Amount ...................       --        --       $ 25,000        --
Promissory Note Issued .........      --        --             25%       --
Date of Maturity ...............      --        --       10/17/98        --
Common Stock Issued ...........      4,545     7,273       12,500     120,482
Series A Preferred Stock Issued       --        --           --          --
Price Per Share ...............   $   5.50   Additional      --      $   0.83
Warrant .......................      2,273     Shares        --          --
Price Per Share ...............   $   2.00   Issued as       --          --
Expiration Date ...............   09/01/00     Price         --          --
Warrant .......................      2,273   Protection      --          --
Price Per Share ...............   $   2.00   Arrangement     --          --
Expiration Date ...............   09/01/00      --           --          --
Series F Warrants .............       --        --           --          --
Price Per Share ...............       --        --           --          --
Expiration Date ................      --        --           --          --
Series G Warrants .............       --        --           --          --
Price Per Share ...............       --        --           --          --
Expiration Date ................      --        --           --          --
Biofund, Inc. CD Collateral Loan      --        --           --          --
Biofund, Inc. Shares Owned .....      --        --           --          --

<CAPTION>
Investment Date ................   08/24/98   02/23/99   05/12/99   11/16/99     Totals
                                   --------   --------   --------   --------     ------
<S>                                <C>        <C>        <C>        <C>        <C>
Amount ........................   $250,000   $ 50,000   $ 50,000       --     $475,000
Loan Amount ...................       --         --         --         --     $ 25,000
Promissory Note Issued .........      --         --         --         --         --
Date of Maturity ...............      --         --         --         --         --
Common Stock Issued ...........    301,205     50,000       --         --      496,005
Series A Preferred Stock Issued       --         --       50,000       --       50,000
Price Per Share ...............   $   0.83   $   1.00   $   1.00       --         --
Warrant .......................    300,000       --         --         --      302,273
Price Per Share ...............   $   1.00       --         --         --         --
Expiration Date ...............   08/31/03       --         --         --         --
Warrant .......................       --         --         --         --        2,273
Price Per Share ...............       --         --         --         --         --
Expiration Date ...............       --         --         --         --         --
Series F Warrants .............       --       50,000       --         --       50,000
Price Per Share ...............       --     $   1.50       --         --         --
Expiration Date ................      --     03/31/04       --         --         --
Series G Warrants .............       --       50,000       --         --       50,000
Price Per Share ...............       --     $   2.00       --         --         --
Expiration Date ................      --     03/31/04       --         --         --
Biofund, Inc. CD Collateral Loan      --         --         --     $200,000   $200,000
Biofund, Inc. Shares Owned .....      --         --         --          200        200


Summary
-------
Epigen, Inc.
  Total Investment                                    $ 500,000
  Common Stock Purchased                                496,005
  Series A Preferred Stock                               50,000
  Exercisable Warrants & Options                        404,545
Biofund, Inc.
  Total Investment                                    $ 200,000
  Shares Owned                                              200

</TABLE>

                                      -38-