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###### Environmental Protection Agency

          - [OPP-00687; FRL-6753-4]

# AGENCY:

 Environmental Protection Agency (EPA).

# ACTION:

 Notice of public meeting.

# SUMMARY:

                         There will be a 3-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and Food Quality Protection Act (FQPA) Scientific Advisory Panel (SAP) to review a set of issues being considered by the Agency pertaining to the following topics: (1) LifeLineTM                         Model Review, and (2) A Case Study of the Cumulative Risk of 24 Organophosphate Pesticides.                    

                        The meeting is open to the public. Seating at the meeting will be on a first-come basis.  Individuals requiring special accommodations at this meeting, including wheelchair access, should contact Olga Odiott at the address listed under                         **FOR FURTHER INFORMATION CONTACT**                         at least 5 business days prior to the meeting so that appropriate arrangements can be made.                    

# DATES:

 The meeting will be held on December 6, 7, and 8, 2000 from 8:30 a.m. to 5:30 p.m.

# ADDRESSES:

                         The meeting will be held at the Sheraton Crystal City Hotel, 1800 Jefferson Davis Highway, Arlington, VA.  The telephone number for the Sheraton Hotel is (703) 486-1111.  Requests to participate may be submitted by mail, electronically, or in person.  Please follow the detailed instructions for each method as provided in Unit I.C. of the                         **SUPPLEMENTARY INFORMATION.**                         To ensure proper receipt by EPA, your request must identify docket control number OPP-00687 in the subject line on the first page of your response.                    

# FOR FURTHER INFORMATION CONTACT:

 Olga Odiott, Designated Federal Official, Office of Science Coordination and Policy, (7101C), Office of Prevention, Pesticides and Toxic Substances, Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460; telephone number: (703) 305-5369; fax number: (703) 605-0656; e-mail address: odiott.olga@epa.gov. 

# SUPPLEMENTARY INFORMATION:

## I. General Information

### A.   Does this Action Apply to Me?

                    This action is directed to the public in general.  This action may, however, be of interest to those persons who are or may be required to conduct testing of chemical substances under the Federal Food, Drug and Cosmetic Act (FFDCA), FIFRA, and FQPA.  Since other entities may also be interested, the Agency has not attempted to describe all the specific entities that may be affected by this action.  If you have any questions regarding the applicability of this action to a particular entity, consult the person listed under                     **FOR FURTHER INFORMATION CONTACT.**

### B. How Can I Get Additional Information, Including Copies of this Document and Other Related Documents?

                    1.                     *Electronically*.  A meeting agenda and copies of EPA primary background documents for the meeting will be available by November 6, 2000.  You may obtain electronic copies of these documents, and certain other related documents that might be available electronically, from the FIFRA/SAP Internet Home Page at http://www.epa.gov./​scipoly/​sap/​. To access this document, on the Home Page, select “                    **Federal Register**                     Notice Announcing This Meeting.” You can also go directly to the                     **Federal Register**                     listings at http://www.epa.gov/​fedregstr/​.                

                    2.                     *In person*                    .  The Agency has established an administrative record for this meeting under docket control number OPP-00687.  The administrative record consists of the documents specifically referenced in this notice, any public comments received during an applicable comment period, and other information related to the (1) LifeLineTM                     Model review, and  (2) A Case Study of the Cumulative Risk of 24 Organophosphate Pesticides, including any information claimed as Confidential Business Information (CBI).  This administrative record includes the documents that are physically located in the docket, as well as the documents that are referenced in those documents. The public version of the administrative record, which includes printed, paper versions of any electronic comments that may be submitted during an applicable comment period, is available for inspection in the Public Information and Records Integrity Branch (PIRIB), Rm. 119, Crystal Mall # 2 (CM #2), 1921 Jefferson Davis Hwy., Arlington, VA, from 8:30 a.m. to 4 p.m., Monday through Friday, excluding legal holidays. The PIRIB telephone number is (703) 305-5805.                

### C. How Can I Request to Participate in this Meeting?

                    You may submit a request to participate in this meeting through the mail, in person, or electronically.  Do not submit any information in your request that is considered CBI. To ensure proper receipt by EPA, it is imperative that you identify docket control number OPP-00687 in the subject line on the first page of your request.  Members of the public wishing to submit comments should contact the person listed under                     **FOR FURTHER INFORMATION CONTACT**                     to confirm that the meeting date and agenda have not been modified. Interested persons are permitted to file written statements before the meeting. To the extent that time permits, and upon advance written request to the persons listed under                     **FOR FURTHER INFORMATION CONTACT**                    , interested persons may be permitted by the Chair of the FIFRA SAP to present oral statements at the meeting. The request should identify the name of the individual making the presentation, the organization (if any) the individual will represent, and any requirements for audiovisual equipment (e.g., overhead projector, 35 mm projector, chalkboard, etc.). There is no limit on the extent of written comments for consideration by the Panel, but oral statements before the panel are limited to approximately 5 minutes.  The Agency also urges the public to submit written comments in lieu of oral presentations.  Persons wishing to make oral or written statements at the meeting should contact the persons listed under                     **FOR FURTHER INFORMATION CONTACT**                     and submit 30 copies of their presentation and/or remarks to the Panel.  The Agency encourages that written statements be submitted before the meeting to  provide Panel Members  the time necessary to consider and review the comments.                

                    1.                     *By mail*.  You may submit a request to:  Public Information and Records Integrity Branch (PIRIB), Information Resources and Services Division (7502C), Office of Pesticide Programs (OPP), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460.                

                    2.                     *In person or by courier*.  Public Information and Records Integrity Branch (PIRIB), Information Resources and Services Division (7502C), Office of Pesticide Programs (OPP), Environmental Protection Agency, Rm. 119, CM #2, 1921 Jefferson Davis Hwy., Arlington, VA.  The PIRIB is open from 8:30 a.m. to 4 p.m., Monday through Friday, excluding legal holidays.  The                           ( print page 66246)                        PIRIB telephone number is (703) 305-5805.                

                    3.                     *Electronically*. You may submit your request electronically by e-mail to:  “opp-docket@epa.gov.” Do not submit any information electronically that you consider to be CBI.  Use WordPerfect 6.1/8.0 or ASCII file format and avoid the use of special characters and any form of encryption. Be sure to identify by docket control number OPP-00687. You may also file a request online at many Federal Depository Libraries.                

## II. Background

### A.  Purpose of the Meeting

This 3-day meeting concerns several scientific issues undergoing consideration within the EPA Office of Prevention, Pesticides and Toxic Substances (OPPTS), as follows.

                    1.                     *LifeLineTM                         Model review*                    .  Review key features of the LifeLineTM                     Model to include the software code, data requirements, data inputs, and output reports.  To assist the Panel in their evaluation of LifeLineTM                     each Panel member will be provided a CD containing the LifeLineTM                     software and supporting documentation.  The Panel will be evaluating hypothetical, yet representative, residue and toxicological data sets for assessing aggregate and cumulative exposure and risk via the dietary, residential and drinking water pathways.                 

                    2.                     *A Case Study of the Cumulative Risk of 24 Organophosphate Pesticides*.  The case study will illustrate data use and the process for integrating multi-pathway exposures to 24 organophosphate pesticides from food, drinking water and residential sources.  This topic will be divided in 4 sessions: (1) Cumulative risk assessment method for dietary (food) exposure, (2) Cumulative risk assessment for residential exposure, (3)  Cumulative risk assessment for drinking water, and (4)  Integrated cumulative risk assessment.  The first three sessions will illustrate how the Agency applied the principles described in the exposure sections of the cumulative risk assessment guidance to monitoring data for residues of organophosphates on food and water.  This approach uses available surrogate data on residential/institutional uses to estimate cumulative exposures/risk using the Relative Potency Factor Method as reviewed by the FIFRA SAP in September, 2000.  The background material will describe the assumptions, procedures, and methods employed in the assessment to estimate the cumulative exposures resulting from each of the three pathways.  An illustration of an approach to integrate exposures from the three pathways into a complete cumulative assessment will be described in session 4.                

### B.  Panel Report

Copies of the Panel's report of their recommendations will be available approximately 45 working days after the meeting, and will be posted on the FIFRA SAP web site or may be obtained by contacting PIRIB at the address and telephone listed below under Unit I.B. of this document.

# List of Subjects

      - Environmental protection

Dated:  October 27, 2000. 

 Steven K. Galson,

Director, Office of Science Coordination and Policy.

[FR Doc. 00-28279 Filed 11-2-00; 8:45 am]

BILLING CODE 6560-50-S