Space Lease dated October 26, 1995.



 Exhibit 10.21 
  
 MASSACHUSETTS BIOTECHNOLOGY RESEARCH PARK 
  
 FOUR BIOTECH PARK 
  
 SPACE LEASE 
  
 THIS LEASE is made in Worcester, Massachusetts effective on the Date of Lease stated in Article 1 between the Landlord and the Tenant named in Article 1.
In consideration of the Rent payable by Tenant and of the agreements to be performed and observed by Tenant, Landlord hereby leases the Premises to Tenant, and Tenant hereby takes the Premises from Landlord, subject to the provisions and for the
term stated below: 
  
 Condition. Notwithstanding
the execution and delivery of this Lease, the obligations of Landlord and Tenant are subject to the execution and delivery to Landlord by EcoScience Corporation of a partial lease termination agreement with respect to the Premises and the redelivery
of the Premises to Landlord as provided in the agreement. 
  
 ARTICLE 1 
  
 Reference Data and Definitions

  
 Section 1.01 - Terms Referred To. Each
reference in this lease to any of the following terms incorporates the data stated for that term in this Section 1.01: 
  
 DATE OF LEASE: October 26, 1995 
  
 LANDLORD: WORCESTER BUSINESS DEVELOPMENT CORPORATION, a Massachusetts corporation established pursuant to the provisions of Chapter 600 of the Acts of 1965, its
successors and assigns. 
  

			
	 LANDLORD’S ADDRESS:
	  	 One Innovation Drive

	 	  	 Worcester, Massachusetts 01605


  
 TENANT: UNISYN TECHNOLOGIES,
INC., a corporation organized under the laws of California. 
  
 TENANT’S
ADDRESS: After the Term Commencement Date, Tenant’s address will be the Premises; before the Term Commencement Date, 

			
	 Tenant’s address will be:
	  	 25 South Street

	 	  	 Hopkinton, Massachusetts 01748


  
 TERM COMMENCEMENT DATE: March
1, 1996 or as defined in Section 1.03, if different. 
  
 STATED EXPIRATION
DATE: February 29, 2006 or as defined in Section 1.03, if different. 
  
 DESIGN START DATE: November 1, 1995 (See Exhibit C – Work Letter) 
  
 PERMITTED USE: Research and development; and limited light manufacturing to the extent authorized under the City of Worcester Zoning Ordinance. 
  

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 LAND Land owned by Waldo Corporation as Trustee of Four Biotech Realty Trust under Declaration of Trust dated
April 15, 1993, recorded with Worcester District Registry of Deeds (the “Registry”) in Book 15199, Page 67, being Parcel 10A on the plan entitled “Plan of Property Owned by Worcester Business Development Corporation of Parcels 10A,
10B, 10C, Plantation Street, Worcester, Massachusetts,” dated December 16,1992 and recorded with the Registry in Plan Book 670, Plan 70, containing a total area of 4.2929 acres, more or less, described in a deed from Worcester Business
Development Corporation to Waldo Corporation as Trustee of Four Biotech Realty Trust dated May 3, 1993 and recorded with the Registry in Book 15199, Page 72. 
  
 PREMISES:* That portion of the first floor of the Building shown as outlined or hatched on the Lease Plan attached as Exhibit B. 
  
 RENTABLE AREA OF THE PREMISES:* 13,788 square feet 
  
 RENTABLE AREA OF THE BUILDING: 92,711 square feet 
  
 TENANT’S SHARE:* 15.1% 
  
 LEASE TERM: Ten (10) Lease Years plus the partial month, if any, between the Term
Commencement Date and the first day of the next calendar month. 
  
 BASIC
RENT:* As provided in the Rent Rider attached as Exhibit E. 
  
 FIXED
RENTAL PERIOD: The first Fixed Rental Period will begin on the Term Commencement Date and end on the last day of the Fifth Lease Year. Thereafter, the Fixed Rental period will be each successive period of three (3) Lease Years beginning on the
first day of the Sixth Lease Year. 
  
 ESTIMATED OPERATING EXPENSES: $5.43
per square foot of Rentable Area for the calendar year in which the Lease Term begins. 
  
 ESTIMATED TAXES: $4.63 per square foot of Rentable Area for the calendar year in which the Lease Term begins. 
  
 INITIAL MONTHLY PAYMENT:* $5,610.13 
  
 SECURITY DEPOSIT: Not Applicable 
  
 GUARANTOR: Not applicable 
  

	*	See Rider and Addendum - 1 and 2 

  

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 Section 1.02 - General Provisions. For all purposes of this Lease, unless the context
otherwise requires: 
  
 (a) A pronoun in one
gender includes and applies to the other genders as well. 
  
 (b) Each definition stated in Section 1.01 or 1.03 of this Lease applies equally to the singular and the plural forms of the word or term defined. 
  
 (c) Any reference to a document defined in Section 1.03 of this Lease is to the document as originally
executed, or, if amended or supplemented as provided in this Lease, to the document as amended or supplemented and in effect at the relevant time of reference. 
  

(d) All accounting terms not otherwise defined in this Lease have the meanings assigned to them under generally accepted accounting
principles. 
  
 (e) All references in Section
1.01 are subject to the specific definitions (if any) in Section 1.03. 
  
 Section 1.03 - Definitions. Each underlined word or term in this Section 1.03 has the meaning stated immediately after it. 
  
 Additional Rent. All Taxes, Operating Expenses, costs, expenses and other charges (other than Basic Rent) due from Tenant to Landlord or incurred
by Landlord as the result of a Default. 
  
 Additional
Services. Services provided to Tenant or in respect of the Premises which are not Basic Services described in Exhibit A. 
  
 Authorizations. All franchises, licenses, permits and other governmental consents issued by Governmental Authorities under Legal Requirements which
are or may be required for the occupancy of the Premises and the conduct of a Permitted Use on the Premises. 
  
 Basic Services. The Landlord’s services described in Exhibit A. 
  
 Building. The building on or to be constructed or under construction on the Land. 
  
 Business Day. A day which is not a Saturday, Sunday or other day on
which banks in Worcester, Massachusetts, are authorized or required by law or executive order to remain closed. 
  

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 Common Areas. All areas of the Building devoted to the common use of the occupants of the Building
or all occupants of multi - tenant floors or the provision of Basic or Additional Services to occupants of the Building, including but not limited to air shafts, pipes, wires, ducts, conduits, elevator shafts and elevators, stairwells and stairs,
restrooms, mechanical rooms, janitor closets, vending areas, loading docks and loading facilities. 
  
 Default. Any event or condition specified in Article 20 so long as any applicable requirements for the giving of notice or lapse of time have not
been fulfilled. 
  
 Event of Default. Any event or
condition specified in Article 20 if all applicable requirements for the giving of notice or lapse of time have been fulfilled. 
  
 Governmental Authority. United States of America, Commonwealth of Massachusetts, City of Worcester, County of Worcester, and any political
subdivision, agency, department, commission, board, bureau or instrumentality of any of them. 
  
 Ground Lease. The lease of the Land (a) from WBDC to Landlord, or if that lease has not been executed as of the date of this Lease, (b) to be entered into between WBDC and its assignee of Landlord’s
interest under this Lease. 
  
 Ground Lessor. WBDC or any
successor under or assignee of the Ground Lease. 
  
 Hazardous
Substances. “Oil”, “hazardous materials”, “hazardous wastes” and “hazardous substances” as those terms are defined under the Comprehensive Environmental Response, Compensation and Liability Act, 42 U.S.C.
Section 9601, et seg. , as amended, the Resource Conservation and Recovery Act of 1976, 42 U.S.C. Section 6901, et seq., as amended, Massachusetts General Laws, Chapters 21C and 21E, as amended, and the regulations from time to time
adopted under those laws. 
  
 Improvements. All (i)
structures located in and forming a part of the Premises, including but not limited to, walls, ceilings, doors and floor covering, (ii) pipes, wires, conduits, controls and fixtures relating to utilities located in and serving the Premises, (iii)
casework, including but not limited to, benches, tables, cabinets and storage facilities, connected to a utility or affixed to the Premises or the Building and (iv) fixtures, equipment and personal property of any kind installed on the Premises in
such a manner that they become part of the Premises or the Building under law or that they cannot be removed without material damage to the structure, fixtures, equipment or personal property or to the Premises or the Building. 
  
 Insurance Requirements. All terms of any policy of insurance
maintained by Landlord or Tenant and applicable to the Land, the Building or the Premises; all requirements of the issuer of any 

  

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such policy; and all orders, rules, regulations and other requirements of the National Fire Protection Association (or any other body exercising similar
functions) applicable to any condition, operation, use or occupancy of all or any part of the Premises. 
  
 Land Disposition Agreement. The agreement dated June 13, 1984 between the Commonwealth of Massachusetts, Division of Capital Planning and
Operations, and WBDC relating to the acquisition by WBDC of the land in the park. 
  
 Landlord’s Fixtures. All fixtures and equipment paid for by Landlord and installed in the Building or the Premises for use by Tenant, whether before or during the Lease Term and whether or not shown in the
Working Drawings, irrespective of whether or how the fixtures or equipment may be affixed to the Premises or the Building. 
  
 Landlord’s Work. The work to be done by Landlord with respect to the Premises described in the Work Letter. 
  
 Lease. This document, all exhibits and riders attached and referred to
in this document and all amendments to this document, the exhibits and riders. 
  
 Lease Term. The period stated in Section 1.01 beginning on the Term Commencement Date. The Lease Term includes the period of any extension exercised by Tenant as provided in this Lease. 
  
 Lease Termination Date. The earliest to occur of (a) the Stated
Expiration Date, (b) the termination of this Lease by Landlord as the result of an Event of Default or (c) the termination of this Lease under Article 17 (Damage or Destruction) or Article 18 (Eminent Domain). 
  
 Lease Year. Each twelve consecutive calendar month period ending on
the day before an anniversary of the Term Commencement Date (or on the day before the first day of the next succeeding calendar month if the Term Commencement Date occurs other than on the first day of a month); provided that (a) the first Lease
Year includes the partial month, if any, between the Term Commencement Date and the first day of the next calendar month and (b) the last Lease Year will end on the Lease Termination Date. 
  
 Legal Requirements. (a) All statutes, codes, ordinances (and rules and
regulations thereunder) and all executive, judicial and administrative orders, judgments, decrees and injunctions of or by any Governmental Authority which are applicable to any condition or use of the Premises, Building or Land, and (b) the
provisions of all Authorizations. 
  
 Occupancy
Arrangement. With respect to all or any part of the Premises or this Lease, and whether (a) written or unwritten or (b) for all or any portion of the Lease Term, an assignment, a sublease, a tenancy at will, a tenancy at sufferance or any other


  

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arrangement (including but not limited to a license or concession) under which a Person occupies the Premises for any purpose. 
  
 Operating Expenses.* All expenses, costs, and disbursements of every
kind which Landlord pays or becomes obligated to pay in connection with the operation, management, repair, cleaning and maintenance of the Land and the Building (including all facilities and equipment in operation on the Term Commencement Date and
such additional facilities and equipment in subsequent years as may be determined by Landlord to be necessary or beneficial in reducing Operating Expenses or protecting the health and safety of occupants of the Building) and the provision of Basic
Services, including, but not limited to (a) wages, salaries and fees, including taxes, insurance, and benefits of all Persons engaged in connection with Basic Services, (b) the cost of (i) supplies and materials, electricity and lighting, for Common
Areas, (ii) water, heat, air conditioning, and ventilating for the Building, (iii) maintenance, janitorial, and service agreements, (iv) snow removal and maintenance of parking and landscaped areas, (v) insurance, including casualty and liability
insurance applicable to the Building and Landlord’s personal property used in connection with the Building, (vi) repairs and general maintenance, (vii) capital items and improvements which are primarily for the purpose of reducing Operating
Expenses, or which are designed to protect the health and safety of occupants of the Building or which may be required by a Governmental Authority, amortized over the reasonable life of the capital items with the reasonable life and amortization
schedule being determined by Landlord in accordance with generally accepted accounting principles, (viii) pursing an application for an abatement of Taxes to the extent not deducted from the abatement, if any, received, (ix) independent auditors,
(x) that portion of Landlord’s central accounting functions allocable to the Building, (c) management fees, not to exceed eight percent (8%) of Basic Rent in any Lease Year, and (d) maintenance charges with respect to the Land imposed on the
Landlord under the Ground Lease. Operating expenses will be determined on the accrual basis in accordance with generally accepted accounting principles consistently applied. 
  
 Operating Expenses do not include (i) costs of services in excess of Basic Services billed to and payable by specific
Tenants; (ii) Taxes, any sales tax, gross receipt tax or similar tax based on Rent, and any income, profits or similar tax imposed on Landlord; (iii) expenditures for capital improvements, and any depreciation or amortization, except amortization of
certain capital expenditures as provided in clause (vii) above; (iv) executive salaries above the grade of building manager; (v) advertising and promotional expenses; (vi) brokerage commissions; (vii) interest, principal and other amounts payable
under any mortgage, and rent payable under the Ground Lease; (viii) expenditures for correcting construction defects in the Building; (ix) expenditures for any alteration, renovation, redecoration, subdivision, layout or finish of any tenant space
in 
  

	*	See Rider and Addendum - 14 

  

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 the Building; (x) cost of any curative action required to remedy damage caused by or resulting from the negligence or
willful act of Landlord, its agents, servants or employees; (xi) legal and other professional fees incurred by Landlord in connection with the leasing of space in the Building and in connection with enforcing leases, or for any other matters not
directly connected to the administration or operation of the Building; and (xii) costs of any type relating to the development of the Building. 
  
 Park. Massachusetts. Biotechnology Research Park created by WBDC pursuant to the provisions of Chapter 317 of the Acts of 1983, as it may be
expanded by amendment of Chapter 317 or by virtue of any other legislation or acquisition by WBDC. 
  
 Permitted Exceptions. Any liens or encumbrances on the Premises of the following character: 
  
 (a) Provisions of Chapter 317 of the Acts of 1983, as
amended; 
  
 (b) Provisions of the Land
Disposition Agreement; 
  
 (c) Rights, easements
and restrictions in the deed dated June 13, 1984 from the Commonwealth of Massachusetts, Division of Capital Planning and Operations, to WBDC recorded with Worcester District Registry of Deeds in Book 8233, Page 106; 
  
 (d) Present and future zoning laws, ordinances resolutions
and regulations of the City of Worcester, including, without limitation, Chapter 17 of the Revised Ordinances of 1986 – Regulations Relative to Biomedical Research in the City of Worcester; 
  
 (e) The lien of any Taxes assessed but not yet due and
payable; 
  
 (f) The Ground Lease; 
  
 (g) Mortgages of record; 
  
 (h) The rights of Landlord and other Persons to whom
Landlord has granted rights to use the Common Areas in common with Tenant; 
  
 (i) The easements created by instruments recorded with Worcester District Registry of Deeds in Book 9538, Page 142 (as modified by Release in Book 12860, Page 119), Book 12717, Page 3 and Book 12860, Page 123, insofar
as they affect the Land; 
  
 (j) All
declarations, covenants, conditions, restrictions, reservations, rights, rights-of-way, easements and other matters of record or apparent affecting the Land or 

  

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the use of the Land now or in the future in force and applicable; and 
  
 (k) Provision of the Declaration of Protective Covenants, Conditions and Restrictions recorded with the
Worcester District Registry of Deeds in Book 12860, Page 145, as they may from time to time in the future be amended. 
  
 Person. An individual, a corporation, a company, a voluntary association, a partnership, a trust, an unincorporated organization or a Governmental
Authority. 
  
 Premises. The space referred to in Section
1.01 located in the Building shown outlined or hatched on Exhibit B (the Lease Plan), excluding exterior walls of the building except the inner surfaces thereof and excluding any Common Areas located within such space. 
  
 Rent. Basic Rent and all Additional Rent. 
  
 Rentable Area of the Premises. The number of square feet stated in the
Section 1.01, irrespective of whether the number should be more or less as a result of minor variations resulting from actual construction of the Building or the Premises so long as such construction is done in accordance with the provisions of this
Lease. 
  
 Stated Expiration Date. The later to occur of
(i) date as stated in Section 1.01, or (ii) last day of the final Lease Year of the Lease Term. 
  
 Substantial Completion Date. The later top occur of (i) the date on which a certificate of occupancy for the Premises is issued by the City of
Worcester, or (ii) the date on which Tenant Fit-up, together with the appurtenant areas of the Building necessary for access and service to the Premises, have been completed as provided in Article 7, except for items of work and adjustment of
equipment and fixtures which are not necessary to make the Premises reasonably tenantable for the Permitted Use or which, because of season or weather or nature of the item, cannot practicably be done at the time. 
  
 Taking. The taking or condemnation of title to all or any part of the
Land or Building or of possession or use of the Land, the Building or the Premises by a Governmental Authority for any public use or purpose, or any proceeding or negotiations which might result in such a taking, or any sale or lease in lieu of such
a taking. 
  
 Taxes. All (i) taxes (or payments in lieu of
taxes), special or general assessments, water and sewer charges, and other charges of every nature imposed by Governmental Authorities which are assessed, become due or become liens upon or with respect to the Land, the Building, the Premises,
Landlord’s Fixtures, equipment owned by Landlord on the Land or in the Building or the Premises, 

  

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or this Lease under all present or future Legal Requirements, and (ii) taxes based on a percentage fraction or capitalized value of the Rent (whether in lieu
of or in addition to the taxes described above) computed as if the Land and the Building were the only property of Landlord subject to such tax. Taxes do not include (a) inheritance, estate, excise, succession, transfer, gift, franchise, income,
gross receipt, or profit taxes except to the extent they are in substitution for Taxes now imposed on the Building, the Land, the Premises or this Lease, or (b) assessments for streets, water or sewer installations or other municipal improvements
made in connection with the initial development of the Building or the Park. 
  
 Tenant Fit-up. All Improvements and other work necessary to prepare the Premises for Tenant’s initial occupancy other than Landlord’s Work. 
  
 Tenant’s Cost. The cost of designing and constructing Tenant
Fit-Up. 
  
 Term Commencement Date. The earliest to occur
of (a) the Substantial Completion Date, (b) any other date for commencement of the Term determined as provided in Article 7 or (c) the date on which Tenant first occupies the Premises for the Permitted Use. 
  
 Total Taking. (i) a Taking of: (a) the fee interest in all or
substantially all of the Land or the Building or (b) such title to or easement in, over, under or such rights to occupy and use any part of the Land or the Building to the exclusion of Landlord as, in the good faith judgment of Landlord,
unreasonably restricts access to the Building by vehicle or renders the portion of the Building remaining after such Taking (even if restoration were made) unsuitable or uneconomical for the continued use and occupancy of the Building for the
Permitted Use or (ii) a Taking of all or substantially all of the Premises or such title to or easement in, on or over the Premises to the exclusion of Tenant which in the good faith judgment of Landlord prohibits access to the Premises or the
exercise, to any material extent, by Tenant of its rights under this Lease. 
  
 Unavoidable Delays. Acts of God, strikes, lock outs, labor troubles, inability to procure materials, failure of power, riots and insurrection, acts of the public enemy, wars, earthquakes, hurricanes and other
natural disasters, fires, explosions, any act, failure to act or default of other party to this Lease or any other reason (except lack of money) beyond the control of any party to this Lease. 
  
 Work Letter. The agreement between Landlord and Tenant with respect to
Tenant Fit-up, substantially in the form of Exhibit C. 
  
 Working Drawings. The detailed plans and specifications developed by Landlord and Tenant as provided in the Work Letter, prepared in compliance with all applicable Legal Requirements stamped by registered Massachusetts professionals,
and consisting 

  

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of all architectural and engineering plans which are required to construct Tenant Fit-up and to obtain any Authorization required for the Premises.

  
 WBDC. Worcester Business Development Corporation, a
Massachusetts corporation established pursuant to the provisions of Chapter 600 of the Acts of 1965. 
  
 ARTICLE 2 
  
 Premises 
  
 Section 2.01 –
Premises. Landlord hereby leases the Premises to Tenant, and Tenant hereby takes the Premises from Landlord, subject to the provisions of this Lease and the Permitted Exceptions. Landlord reserves the right to relocate within or without the
Premises pipes, ducts, vents, flues, conduits, wires and appurtenant fixtures which service other parts of the Building; provided that such work is done in a manner that it does not unreasonably interfere with Tenant’s use of the Premises.

  
 Section 2.02 – Appurtenances. Tenant may
use the Common Areas and the Land as appurtenant to the Premises for the purposes for which they were designed. Tenant, its employees and business invitees have the non-exclusive right to use the parking areas on the Land. 
  
 Section 2.03 – Landlord’s Fixtures. Tenant may use
the Landlord’s Fixtures during the Lease Term. Landlord’s Fixtures remain the property of Landlord and may not be removed by Tenant whether or not they are affixed to the Building. 
  
 ARTICLE 3 
  
 Term 
  
 Section 3.01 – Term Commencement. The Lease Term will begin on the Term Commencement Date. 
  
 Section 3.02 – Termination. The Lease Term will end on the
Lease Termination Date. 
  
 Section 3.03 – Estoppel
Certificate. If either the Term Commencement Date or the Stated Expiration Date occurs on a date other than as stated in Section 1.01, Landlord and Tenant agree to execute a certificate in the form of the estoppel certificate referred to in
Section 25.02 or such other form as either may request, establishing the Term Commencement Date and the Stated Expiration Date. 
  

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 ARTICLE 4 
  

Rent 
  
 Section 4.01 - Basic Rent. Tenant agrees to pay Landlord the Basic Rent as annual rent for the Premises for each Lease Year, without offset
or deduction and without previous demand. Tenant agrees to pay Basic Rent in equal monthly installments in advance on the first day of each calendar month during the Lease Term, except that the first installment of Basic Rent, pro-rated for the
partial month, if any, at the beginning of the Lease Term, will be paid on the Term Commencement Date. 
  
 Section 4.02 - Adjustment of Basic Rent. The Basic Rent for each Lease Year during the first Fixed Rental Period will be as stated in
Section 1.01. The Basic Rent for each Lease Year of each successive Fixed Rental Period, if any, will be as stated in Exhibit E, the Rent Rider. 
  
 ARTICLE 5 
  
 Use of Premises 
  
 Section 5.01 - Use Restricted. The Premises may be used for the Permitted Use and for no other purpose. Tenant agrees not to make any use of the Premises that would cause the Premises to be considered a
“place of public accommodation” under the Americans with Disabilities Act of 1990. No Improvements, alterations or additions may be made in or to the Premises except as provided in this Lease. 
  
 ARTICLE 6 
  
 Operating Expenses; Taxes 
  
 Section 6.01 - Operating Expenses and Taxes. Tenant agrees to pay Landlord, as Additional Rent, (i)
Tenant’s Share of Operating Expenses and Taxes as provided in this Article 6, pro-rated for any partial calendar year falling within the Lease Term, and (ii) all Taxes assessed with respect to Improvements or structures anywhere in the park
constructed by or on behalf of Tenant after the Substantial Completion Date. 
  
 Section 6.02 - Monthly Payments of Additional Rent. Tenant agrees to pay to Landlord in advance for each calendar month of the Lease Term, as Additional Rent, Operating Expenses and Taxes in an amount
equal to (a) 1/12th of the product of (i) Estimated Operating Expenses for the then current calendar year times (ii) the Rentable Area of the Premises, plus (b) 1/12th of the product of (i) Estimated Taxes for the then current calendar year 

  

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times (ii) the Rentable Area of the Premises. Tenant agrees to pay the amount payable under this Section 6.02 with Tenant’s monthly payments of Basic
Rent. The amounts paid will be credited by Landlord to Tenant’s obligations under Section 6.01. For the balance of the first calendar year at the beginning of the Lease Term the amount payable by Tenant each month with respect to Tenant’s
Share of Estimated Operating Expenses and Estimated Taxes will be the Initial Monthly Payment stated in Section 1.01, which amount will be pro-rated for the partial month, if any, at the beginning of the Lease Term and paid beginning on the Term
Commencement Date. 
  
 Section 6.03 - Annual
Statements. Within sixty (60) days after the end of each calendar year, Landlord agrees to render to Tenant a statement, prepared in accordance with generally accepted accounting practices, showing in reasonable detail (i) for the calendar
year just ended (if any) (a) the amount of Taxes, (b) the amount of Operating Expenses and (c) a calculation of Tenant’s Share of Taxes and Operating Expenses, and (ii) for the then current calendar year, the amount of Estimated Operating
Expenses and Estimated Taxes determined by Landlord in the reasonable exercise of its judgment. Estimated Operating Expenses and Estimated Taxes for the calendar year in which the Lease Term begins are the sums set forth in Section 1.01. If the
total amount paid by Tenant on account of Operating Expenses or Taxes or both in any calendar year exceeds the actual amount of Tenant’s Share of Operating Expenses or Taxes for the year, then the excess will be credited by Landlord against the
monthly installments of Additional Rent next falling due or refunded to Tenant upon the expiration or termination of this Lease, if earlier (unless such expiration or termination is the result of an Event of Default). If the total amount of
Operating Expenses or Taxes or both paid by Tenant in any calendar year is less than the actual amount of Tenant’s share of Operating Expenses or Taxes for the year, then Tenant agrees to pay the difference to Landlord within thirty (30) days
after receipt by Tenant of Landlord’s statement. Not more frequently than once each Lease Year, Tenant may, at its expense and after ten (10) Business Days prior notice, audit Landlord’s records relating to Operating Expenses. 

 
 Section 6.04 - Assessments and Other Taxes. Landlord agrees
that all special and general assessments will be paid in installments over the longest period permitted by law and that the amount of Taxes shown on each annual statement will include only the portion due in that year. Nothing in this Lease shall be
construed to require Tenant to pay any inheritance, estate, excise, succession, transfer, gift, franchise, income, gross receipt, or profit taxes that are, or may be, imposed upon Landlord, its successors or assigns, except to the extent such taxes
are in substitution for Taxes as now imposed on the Building, the Land, the Premises or this Lease. 
  
 Section 6.05 - Accounting Periods. Landlord may from time to time change the periods of accounting under this Lease to any annual period
other than a calendar year. Upon any such change, 

  

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all items referred to in this Article 6 will be appropriately apportioned. In all statements rendered under Section 6.03, amounts for periods partially
within and partially outside of the accounting periods will be appropriately apportioned. Any items which are not determinable at the time of a statement will be included on the basis of Landlord’s estimate. Promptly after determination,
Landlord will render a supplemental statement in which appropriate adjustment will be made. 
  
 Section 6.06 - Abatement of Taxes. Landlord may at any time and from time to time make application to the appropriate Governmental Authority of an abatement of Taxes. Landlord agrees to make such an
application at any time tenants occupying more than 60% of the Rentable Area of the Building under written Occupancy Arrangements directly with the Landlord request that Landlord do so. If (i) such an application is successful and (ii) Tenant has
made any payment in respect of Taxes under this Article 6 for the period with respect to which the abatement was granted, Landlord agrees (a) to deduct from the amount of the abatement all expenses incurred by it in connection with the application
(b) within thirty (30) days after receipt of the abatement amount to pay to Tenant Tenant’s Share (adjusted for any period for which Tenant had made a partial payment) of the abatement, with interest, if any, paid by the Governmental Authority
on such abatement, and (c) retain the balance, if any. 
  
 Section 6.07 - Exemption From Taxes. As provided in Section 6 of Chapter 317 of the Acts if 1983, Landlord may be or become exempt from the obligation to pay Taxes if it leases any part of the Building to an organization
exempt from taxes under the United States Internal Revenue Code. If Tenant is able to establish to Landlord’s satisfaction the amount of the reduction in Taxes during any calendar year which is a result of this Lease and Tenant’s
tax-exempt status, Tenant’s obligation to pay Taxes for such calendar year as provided in this Article 6 will abate in the same amount, or the amount, if previously paid, will be refunded to Tenant. If Tenant is not tax-exempt but
Landlord’s obligation to pay Taxes is abated because of the tax-exempt status of any other tenant or tenants of the Building, Landlord reserves the right to increase Tenant’s Share as it relates to Taxes so that the Taxes payable with
respect to the Land and the Building for any calendar year during the Lease Term are equitably apportioned among the tenants of the Building who are not exempt from taxation. 
  
 ARTICLE 7 
  
 Improvements 
  
 Section 7.01 - Tenant Fit-up. In connection with the preparation of the Premises for Tenant’s initial occupancy, Landlord agrees to do
Landlord’s Work and Tenant Fit-up as described in the Working Drawings. Landlord agrees to perform all 

  

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work in a good and workmanlike manner and in compliance with all Legal Requirements and Insurance Requirements, subject to the provisions of the Work Letter.
Unless otherwise agreed, Tenant agrees to pay Tenant’s Cost as Additional Rent in installments as the work progresses as provided in the agreement with the contractor performing the work and in any event on or before the Term Commencement Date.

  
 Section 7.02 - Time for Completion. Landlord
agrees to use due diligence to have the Premises ready for occupancy on or before the Term Commencement Date referred to in Section 1.01. Reference is made to the Work Letter for details of the completion process. 
  
 Section 7.03 - Notice of Substantial Completion Date.
Approximately fifteen (15) days before it occurs, Landlord agrees to give Tenant a notice stating the Substantial Completion Date. 
  
 Section 7.04 - Delays. If Landlord is delayed in substantially completing Tenant Fit - up as the result of 
  
 (a) delay by Tenant or any Person employed by Tenant in
delivery to Landlord of any plans, design work and detailed drawings, or 
  
 (b) Tenant’s request for special work not part of the work described in the Working Drawings or for changes to the Working Drawings after approval by Tenant (notwithstanding Landlord’s approval of such
changes), or 
  
 (c) delays in performance by
Tenant or any Person employed by Tenant which cause delays in the completion of any work to be done by Landlord or which otherwise delay the substantial completion of the Premises, or 
  
 (d) any fault, negligence, omission, or failure to act on the part of Tenant or its agents, contractors,
workmen, mechanics, suppliers or invitees, 
  
 provided Tenant has been given
notice of each such delay, the Premises will be substantially completed on ( and the Term Commencement Date will be) that date determined by Landlord, in the reasonable exercise of its judgment, on which the Substantial Completion Date would have
occurred but for the delays referred to in this Section 7.04. 
  
 Section 7.05 - Tenant’s Access to the Premises. Tenant and Tenant’s agents, at Tenant’s sole risk, may, with Landlord’s prior consent, enter the Premises before the Term Commencement Date in order to (a)
install its furniture, furnishings and equipment and (b) perform or inspect work necessary to make the Premises ready for Tenant’s use and occupancy. If Landlord permits entry before the Term Commencement Date, the permission is conditioned
upon (i) Tenant delivering to Landlord evidence of the insurance required under Section 15.01 and (ii) Tenant and Tenant’s agents, 

  

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contractors, workmen, mechanics, suppliers and invitees, working in harmony with Landlord and contractors working for Landlord and with other tenants of the
Building. If at any time Tenant’s entry causes or threatens to cause disharmony or interfere with the orderly completion or operation of the Building, Landlord may withdraw the permission upon notice to Tenant. Any entry by Tenant will be
deemed to be under all of the provisions of this Lease except the covenant to pay Rent. Except for the negligence of Landlord and its employees, if Tenant or its agents enter the Premises before the Term Commencement Date, Landlord will not be
liable for and Tenant agrees to assume the entire risk for any loss or damage which may occur to any Improvements or to any property placed in the Premises before the Term Commencement Date. 
  
 Section 7.06 - Improvements by Tenant. Tenant agrees not to
hang shades, curtains, signs, awnings or other materials in any window, attach any materials to or make any change in the appearance of any glass visible from outside of the Premises, add any window treatment of any kind or make Improvements or
install furniture visible from outside of the Premises, without Landlord’s prior written consent. Tenant agrees not to make any Improvements before or during the Lease Term, the total cost of which during any twelve (12) consecutive months
exceeds $5,000, unless Landlord first approves the plans and specifications for the Improvements and the contractors performing the work. Tenant agrees not to make any Improvements which would (a) delay completion of the Premises of the Building, or
(b) require unusual expense to readapt the Premises to normal research and development, general office and limited light manufacturing use upon termination of this Lease or (c) increase (i) the cost of Landlord’s Work or insurance or (ii)
Taxes. All Improvements will become part of the Premises and property of Landlord upon their completion or installation except to the extent Landlord specifies that they must be removed at Tenant’s expense on the Lease Termination Date as an
express condition to Landlord’s approval of their initial installation. The construction of Improvements by Tenant and the installation of Tenant’s furniture, furnishings and equipment will be coordinated with any-work being performed by
Landlord and will be performed in such manner as to maintain harmonious labor relations and not to damage the Building or the Premises or interfere with Building operation. Except for work done by or through Landlord before making any Improvements,
Tenant will: secure all necessary Authorizations; deliver to Landlord a statement of the names of all its contractors and subcontractors and the estimated cost of all labor and material to be furnished by them; cause each contractor to carry (1)
worker’s compensation insurance in statutory amounts covering all the contractor’s and subcontractor’s employees, (2) comprehensive public liability insurance with such limits as Landlord may reasonably require, but in no event less
than $1,000,000, and (3) property damage insurance with limits of not less than $300,000 (all such insurance to be written by companies approved by Landlord and insuring Landlord and Tenant as well as the contractors), and to deliver to Landlord
certificates of all such insurance; and secure casualty insurance against loss or damage to the Improvements pending completion and deliver evidence of such insurance to Landlord. Tenant agrees to pay promptly when due the entire cost 

  

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of any work done in the Premises by Tenant, its agents, employees, or independent contractors, and not to cause or permit any liens for labor or materials
performed or furnished in connection with its work to attach to the Premises and immediately to discharge any such liens which may attach. All construction work done by Tenant, its agents, employees or independent contractors will be done in a good
and workmanlike manner and in compliance with all Legal Requirements and Insurance Requirements. Landlord may inspect the work at any time and will promptly give notice to Tenant of any observed defects. 
  
 ARTICLE 8 
  
 Building Services 
  
 Section 8.01 - Basic Services. During the Lease Term, Landlord agrees to furnish, or cause to be furnished, the Basic Services. 

 
 Section 8.02 - Other Janitors. No Person will be employed by
Tenant to do janitorial work in the Premises and no Person other than the janitors of the Building will clean the Premises unless first approved in writing by Landlord. Any Person employed by Tenant with Landlord’s approval to do janitorial
work will, while in the Building, either inside or outside the Premises, be subject to and under the control and direction of the superintendent of the Building (but not as agent or servant of the superintendent or of Landlord). 
  
 Section 8.03 - Additional Services. Tenant agrees to pay
Landlord a reasonable charge for any extra cleaning of the Premises required because of the carelessness or indifference of Tenant and for any Additional Services rendered at the request of Tenant. If the cost of cleaning the Premises is increased
due to the installation in the Premises, at Tenant’s request, of any unique or special materials, finish or equipment, Tenant agrees to pay the Landlord an amount equal to the increase in cost. All charges for Additional Services will be
payable within ten (10) days after the date on which they are billed. 
  
 Section 8.04 - Limitations on Landlord’s Liability. * Landlord will not be liable in damages nor in default under this Lease for any failure or delay in furnishing Basic Services or Additional Services when the failure or
delay is caused by Unavoidable Delays. No failure or delay by Landlord in furnishing Basic Services or Additional Services caused by Unavoidable Delays may be claimed or pleaded as an eviction or disturbance of Tenant’s possession or give
Tenant any right to terminate this Lease or give rise to any claim for set-off or abatement of Rent or excuse Tenant from the performance of any of its obligations under this Lease. 
  

	*	See Rider and Addendum - 15 

  

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 Section 8.05 - Electric Service. Tenant agrees to make its own arrangements for the
provision of electricity to the Premises and to pay the full cost (as shown on a separate electric meter to be installed at Landlord’s expense) directly to the utility company providing the electricity. Tenant’s use of electricity in the
Premises will not at any time exceed the capacity of any of the electrical conductors or equipment in or serving the Premises. In order to insure that such capacity is not exceeded and to avert possible adverse effect upon the Building electric
service, Tenant agrees it will not, without prior written notice to Landlord in each instance, connect to the Building electric distribution system any fixtures, appliances or equipment which operate on a voltage in excess of 208 volts nominal or
make any alteration or addition to the electric system of the Premises. Unless Landlord objects to the connection of any such fixtures, appliances or equipment, all additional risers or other equipment required for the connection will be provided by
Landlord, and the cost will be paid by Tenant on Landlord’s demand. 
  
 ARTICLE 9 
  
 Tenant’s Covenants

  
 Section 9.01 - Pay Rent. Tenant agrees
to pay when due all Rent and all charges for utility services rendered to the Premises not included in Rent and, as Additional Rent, all charges of Landlord for Additional Services. 
  
 Section 9.02 - Occupancy of the Premises. Tenant agrees to occupy the Premises for the Permitted Use only.
Tenant will not (i) injure or deface the Premises or the Building, (ii) install any sign in or on any window, demising wall, corridor, elevator foyer or other common Area, (iii) permit in the Premises any inflammable fluids or chemicals not
reasonably related to the Permitted Use, nor (iv) permit any nuisance or use of the Premises which is improper, offensive, contrary to any Legal Requirement or Insurance Requirement or liable to render necessary any alteration or addition to the
Building. 
  
 Section 9.03 - Rules and Regulations.
Tenant agrees not to obstruct in any manner any portion of the Building or the Land. Tenant agrees to comply with all reasonable rules and regulations of which Tenant has notice promulgated by Landlord and uniformly applicable to Persons occupying
the Building regulating the details of the operation and use of the Building. 
  
 Section 9.04 - Safety. Tenant agrees to keep the Premises equipped with all safety appliances required by Legal Requirements or Insurance Requirements applicable to Tenant specifically because of any use
made by Tenant and not applicable to generally to all other tenants of the Building. Tenants agrees to procure all Authorizations required because of Tenant’s use of the Premises 

  

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and to do any work required under any Authorization because of such use, it being understood that the provisions of this Section may not be construed to
broaden in any way the Permitted Use. 
  
 Section 9.05 -
Equipment. Tenant agrees not to place a load upon the floor of the Premises exceeding the live load for which the floor has been designed. Tenant agrees not to move any safe or other heavy equipment into, about or out of the Premises except
in the manner and at the time authorized by Landlord in each instance. Tenant agrees to isolate and maintain all of Tenant’s equipment which causes or may cause airborne or structure-borne vibration or noise, whether or not it may be
transmitted to any other part of the Building, so as to eliminate such vibration or noise. 
  
 Section 9.06 - Pay Taxes. Tenant agrees to pay promptly when due all Taxes upon personal property (including, without limitation, fixtures and equipment) in the Premises irrespective of the Person to
whom the Taxes may be assessed. 
  
 Section 9.07 -
Maintenance. Tenant agrees, at all times during the Lease Term, and at its own expense, (i) to maintain the Premises in good repair and condition (except for (a) ordinary wear and tear, (b) damage by fire or casualty and (c) any defect in
material or workmanship performed by Landlord in connection with initial preparation of the Premises for Tenant’s use and occupancy), (ii) to use all reasonable precautions to prevent waste, damage or injury to the Premises or any other part of
the Building and (iii) to repair all damage to any part of the Building caused by Tenant or any of Tenant’s agents, employees or invitees, to the extent that such damage is not covered by Landlord’s insurance. 
  
 Section 9.08 - Redelivery. On the Lease Termination Date,
Tenant agrees to leave the Premises and surrender possession to Landlord free of (i) all tenants or occupants claiming through or under Tenant, and (ii) all liens encumbrances, restrictions or reservations caused_ or consented to by Tenant. Tenant
agrees, subject to the provisions of Articles 17 and 18, to surrender the Premises, including all Landlord’s Fixtures and all Improvements except those which Tenant is required to remove as provided in Section 7.06, to Landlord broom clean and
in good condition and repair (ordinary wear and tear and damage by fire or other casualty only excepted) with all damage resulting from removal of (i) Tenant’s furniture, furnishings and equipment and (ii) any Improvements which Tenant is
required to remove as provided in Section 7.06 repaired at Tenant’s expense to Landlord’s reasonable satisfaction. 
  
 Section 9.09 - Tenant Financial Information. Tenant agrees to deliver to Landlord (i) within thirty (30) days after the last day of each
fiscal quarter other than the fourth quarter, a management prepared statement of Tenant’s income and expense for the preceding quarter and Tenant’s balance sheet as of the end of the quarter, and (ii) within seven (7) days after receipt by
Tenant, a copy of its year-end financial report audited by Tenant’s certified public accountants. 

  

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and containing statements of Tenant’s income and expenses for the preceding fiscal year and Tenant’s balance sheet as of the end of the fiscal
year. Whenever requested by Landlord in connection with financing of the Building or its own operations, Tenant agrees to provide to Landlord all information currently available relating to Tenant’s existing and future financial condition,
including but not limited to internally and externally prepared financial statements and reports, prospectuses and offering circulars, underwriting agreements private placement memoranda and similar documents involving public and private funding
sources. Landlord agrees to maintain all the information in strictest confidence except to the extent necessary to share it with lenders in connection with financing of the Building or its own operations. 
  
 ARTICLE 10 
  
 Compliance with Requirements 
  
 Section 10.01 - Legal Requirements. Tenant agrees, at its
expense, promptly to observe and comply with all Legal Requirements relating to it specifically or its use of the premises and not applicable generally to all other tenants of the Building. Tenant agrees to pay all costs, liabilities, losses,
damages, fines, penalties, claims and demands, that may arise out of or be imposed because of the failure of Tenant to comply with the covenants of this Article 10. 
  
 Section 10.02 - Contests. Tenant has the right to contest by appropriate legal proceedings diligently
conducted in good faith, in the name of Tenant or Landlord (if legally required) or both (if legally required), without expense or liability to Landlord, the validity or application of any Legal Requirement. If compliance with the terms of any Legal
Requirement may legally be delayed pending the prosecution of any such proceeding, Tenant may delay compliance until the final determination of the proceeding. 
  

Section 10.03 - Land Disposition Agreement. As required under the Land Disposition Agreement, Tenant, working with the public and private
higher educational institutions of Worcester and existing or future federal, state and local job training programs, agrees to endeavor to establish education and training programs to assist Worcester residents and women and minority group members in
developing skills necessary for future employment within or ancillary to the Park and to establish fair and equitable procedures to provide employment opportunities for qualified residents of the City of Worcester and women and minority group
members on a priority basis. 
  
 Section 10.04 -
Environmental Legal Requirements. Except to the extent permitted under applicable Legal Requirements, Tenant agrees not to cause or permit any Hazardous Substances to be released on the Land or in the Building or the Premises or into the
air, or to be introduced into the sewage or other waste disposal system serving the Premises. Tenant agrees to generate, store or dispose of Hazardous Substances in the Premises or dispose of Hazardous Substances from the Premises to any other


  

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location only in compliance with all applicable Legal Requirements and to notify Landlord of any incident which would require the filing of a notice under
any Legal Requirement. Tenant agrees to provide Landlord with such information required by Governmental Authorities as Landlord may reasonably request from time to time with respect to compliance with this Section. 
  
 ARTICLE 11 
  
 Covenant Against Liens 
  
 Section 11.01 - No Liens. Tenant agrees not to create any lien
on the Premises, the Building or the Land and to discharge any lien on the Premises, the Building or the Land arising out of any act or omission by Tenant, including but not limited to any tax, mechanic’s, laborer’s or materialman’s
lien or lien arising under Massachusetts General Laws, Chapter 21E. 
  
 Section 11.02 - Discharge. If any lien is filed against the Premises, the Building or the Land as a result of any act or omission by Tenant, Tenant agrees to cause the lien to be discharged of record by payment, deposit, bond,
order of a court of competent jurisdiction or otherwise, within sixty (60) days after (i) Tenant has actual or constructive notice that it is filed, or (ii) final judgment in favor of the holder of the lien. If Tenant fails to cause the lien to be
discharged, then, in addition to any remedies available to Landlord in case of an Event of Default, Landlord may, but is not obligated to, discharge the lien either by paying the amount claimed to be due or by procuring the discharge of the lien by
deposit or by bonding proceedings. Any amount paid by Landlord and all costs incurred by Landlord in connection the removal of any lien will constitute Additional Rent and will be paid by Tenant to Landlord on demand with interest as provided in
Section 21.06. 
  
 ARTICLE 12 
  
 Access to Premises 
  
 Section 12.01 - Access. Landlord or Landlord’s agents and
designees will have the right, but not the obligation, to enter the Premises at all reasonable times during ordinary business hours, after not less than twenty-four hours notice except in the case of an emergency, to examine the Premises, to make
necessary repairs and replacements and to exhibit the Premises to prospective purchasers, mortgagees, and, during the last six (6) months of the Lease Term, prospective tenants. Except in the case of an emergency, any Person entering the Premises
under this Section 12.01 will be accompanied by a Person designated by Tenant, if Tenant requires. 
  

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 ARTICLE 13 

 
 Assignment and Subletting: Occupancy Arrangements 

 
 Section 13.01 - Assignment and Subletting. Tenant agrees not
to enter into any Occupancy Arrangement, either voluntarily or by operation of law, (other than with a Person who is affiliated with Tenant and for a period ending when and if such Person ceases to be affiliated with Tenant) without the prior
written consent of Landlord. For purposes of this Article 13, a Person will be considered to be affiliated with Tenant if such Person; directly or indirectly, control, is controlled by or is under common control with Tenant. 
  
 Section 13.02 - Procedure.* If Tenant intends to enter into an
Occupancy Arrangement which requires Landlord’s consent, Tenant agrees to give Landlord notice of the name of (and a financial statement with respect to) the proposed occupant, the exact terms of the Arrangement and a precise description of the
portion of the Premises intended to be subject to the Occupancy Arrangement. Within thirty (30) days after receipt of the notice, Landlord will (i) consent to the Occupancy Arrangement, or (ii) refuse to consent to the Occupancy Arrangement, or
(iii) notify Tenant of Landlord’s election to terminate this Lease with respect to so much of the Premises as is intended to be subject to the Occupancy Arrangement. If Landlord consents to the Occupancy Arrangement. Tenant agrees (i) to enter
into the Arrangement on the exact terms described to Landlord within thirty (30) days after Landlord’s consent and to deliver to Landlord and to the holder of any first mortgage on the Building an executed original counterpart of the Occupancy
Arrangement and (ii) to remain liable for the payment and performance of the provisions of this Lease. If Tenant enters into an Occupancy Arrangement, Tenant agrees to pay to Landlord when received the excess, if any, of amounts received in respect
of the Occupancy Arrangement over the Rent. Any Occupancy Arrangement will expressly incorporate and be subject to the terms of this Lease, which terms will be binding on all parties to the Occupancy Arrangement. If Landlord consents to and Tenant
does not enter into the Arrangement within the thirty (30) day period, such consent will be deemed revoked and Tenant will again comply with the terms of this Section. If Landlord elects to terminate this Lease with respect to that portion of the
Premises to be subject to the Occupancy Arrangement, this Lease will terminate as of the date specified in the election, which date will be not less than thirty (30) days nor more than sixty (60) days after the date of the election; provided that
Tenant may, at any time before the date of termination, withdraw its request for Landlord’s consent to an Occupancy Arrangement. Such withdrawal by Tenant will nullify Landlord’s election to terminate, and this Lease will remain in effect
as if no election by Landlord had been made. If Landlord terminates this Lease, all Rent due will be adjusted as of the day the Premises (or the portion affected by the termination) are redelivered to Landlord. Any portion of the Premises
redelivered to Landlord will be in the condition specified in Section 9.08. 
  

	*	See Rider and Addendum - 6 

  

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 ARTICLE 14 

 
 Indemnity 
  
 Section 14.01 - Tenant’s Indemnity. Except to the extent
waived by Landlord under the provisions of Section 16.02, Tenant agrees to indemnify Landlord against all claims, losses and expenses, including reasonable attorneys’ fees, which may be imposed upon or incurred by Landlord by reason of any of
the following occurrences: 
  
 (a) any act or
omission on the Premises by Tenant or any Person other than Landlord, its agents, contractors, licensees or invitees; 
  
 (b) any use, non-use, possession, occupation, condition, operation, maintenance or management of the Premises; 
  
 (c) any act or omission on the part of Tenant, or any of its
agents, contractors, licensees or invitees, whether or not occurring on the Premises; 
  
 (d) any accident, injury or damage to any Person or property occurring in the Premises, not due to any act or omission of Landlord, its
agents, contractors or Licensees; 
  
 (e) any
failure on the part of Tenant to comply with any of its obligations under this Lease, whether or not such failure constitutes a Default or Event of Default; 
  
 (f) any untrue or misleading statement of a material fact or any misrepresentation of a material fact made by or on behalf of Tenant in
connection with the negotiation of this Lease; or 
  
 (g) any release or threat of release of Hazardous Substances by Tenant, or any of its agents, contractors, licensees or invitees, whether or not occurring on the Premises. 
  
 Section 14.02 - Claims by Landlord. If a proceeding is brought against Landlord arising out of an occurrence
described in Section 14.01, upon notice from Landlord Tenant agrees, at its expense, to defend the proceeding using legal counsel reasonably satisfactory to Landlord or, if applicable, Tenant’s insurer, provided that Tenant has not been
prejudiced by failure or delay on the part of Landlord to give Tenant prompt notice of the proceeding. If Tenant has supplied Landlord with insurance covering an occurrence described in Section 14.01, no claim may be made against Tenant with respect
to that occurrence unless the insurer fails or refuses to defend and/or pay all claims, losses and expenses incurred by Landlord. Notwithstanding the foregoing, Landlord has the right to make claims, institute legal 

  

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proceedings, or otherwise seek redress against Tenant before the expiration of any statute of limitations or other limitation on the time or manner in which
Landlord may seek redress regardless of whether or not an insurer is responding. 
  
 Section 14.03 - Landlord’s Liability.* Except for its intentional acts or negligence or the intentional acts or negligence of its agents, contractors or licensees, Landlord will not be responsible
or liable for any loss, damage or injury to the Premises or to any Person or property at any time on the Land or in the Building or the Premises. 
  
 ARTICLE 15 
  
 Insurance 
  
 Section 15.01 - Tenant’s Insurance. Tenant agrees to provide, at its expense, and to keep in force: 
  
 (a) Comprehensive general liability insurance against claims for personal injury, death and property damage occurring with respect to
Tenant’s occupancy of the Premises having primary combined single limit coverage of at least $1,000,000 for bodily injury and property damage. 
  
 (b) Casualty insurance against loss or damage to (i) all inventory, furniture, furnishings and equipment other than Landlord’s
Fixtures owned, controlled or in use by Tenant and situated in the Building, (ii) all Improvements made by Tenant pending completion and (iii) all Improvements made by Tenant which Tenant is required to remove on the Lease Termination Date under
Section 7.06, under a so-called “All Risk” policy in an amount sufficient to replace the same without allowance for depreciation, if available, and if not, in the amount necessary to avoid the effect of co-insurance provisions under the
applicable policies. 
  
 (c) Worker’s
compensation insurance for all Tenant’s employees working in the Premises in an amount sufficient to comply with Legal Requirements. 
  
 (d) Such greater limits and such other insurance and in such amounts as may from time to time be reasonably required by Landlord against
other insurable hazards which at the time are customarily insured against in the case of buildings similarly situated and used. 
  
 Section 15.02 - General Insurance Provisions. 
  
 (a) All insurance provided for in Section 15.01 will be written as primary policies (without “contribution” or “solely in
excess of coverage carried by Lessor” provisions) and will be effected under valid and enforceable policies, 
  

	*	See Rider and Addendum - 17 

  

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 issued by insurers of recognized responsibility authorized to write such insurance in Massachusetts and
having a Best’s financial rating of B or better. Not less than five (5) days before the Term Commencement Date, and thereafter not less than ten (10) days before the expiration dates of the expiring policies furnished under to Section 15.01,
binders, certificates or other evidence of such insurance satisfactory to Landlord bearing notations evidencing the payment of premiums or accompanied by other evidence satisfactory to Landlord of such payment, will be delivered by Tenant to
Landlord. 
  
 (b) Nothing in this Article 15 will
prevent Tenant from taking out insurance of the kind and in the amounts provided for under this Article under a blanket insurance policy or policies covering other properties as well as the Premises. Any policy or policies of blanket insurance (i)
will specify, or Tenant will furnish Landlord with a written statement from the insurers specifying, the amounts of the total insurance allocated to the Premises, which amounts will not be less than the amounts required by Section 15.01 and will be
sufficient to prevent any of the insureds from becoming a co-insurer within the terms of the applicable policy or policies, (ii) will contain an “Agreed Amount” clause as to the Premises and (iii) will otherwise comply as to endorsements
and coverage with the provisions of this Article. 
  
 (c) All policies of insurance provided for in Section 15.01 will name Landlord and Tenant as the insured, as their respective interests may appear, and also the Ground Lessor and any mortgagee, when requested, as their respective interests
may appear, except that Landlord, the Ground Lessor and any such mortgagee will have no interest in the insurance on Tenant’s personal property. Each such policy or certificate issued by the insurer will, to the extent obtainable, contain an
agreement by the insurer that the insurance will not be cancelled without at least twenty (20) days prior written notice to Landlord and to any other named insureds. Landlord agrees not to carry any insurance concurrent in coverage and contributing
in the event of loss with any insurance required to be furnished by Tenant if the effect of such separate insurance would be to reduce the protection or the payment to be made under Tenant’s insurance. 
  
 Section 15.03 - Landlord’s Insurance. Landlord agrees to
cause the Building (including Landlord’s Fixtures but excluding any Improvements and leasehold improvements (a) by any tenant prior to their completion, or (b) which any tenant may be required to remove upon termination of its lease) to be
insured for the benefit of Landlord, the Ground Lessor and any mortgagee of Landlord, as their respective interests may appear, against loss or damage under a so-called “All Risk” policy in an amount equal 

  

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to (i) the replacement value or (ii) the amount necessary to avoid the effect of co-insurance provisions of the applicable policies. Land_ord also agrees to
maintain comprehensive form boiler insurance, rental value insurance and such other insurance against such perils and in such amounts as may be required by the Ground Lessor or any mortgagee of Landlord or as Landlord may consider prudent. The cost
of such insurance will be part of the Operating Expenses. 
  
 ARTICLE 16 
  
 Waiver of Subrogation

  
 Section 16.01 - Waiver of Subrogation. If
available, all insurance policies carried by either party covering the Building and/or the Premises will contain a clause or endorsement expressly waiving any right on the part of the insurer to make any claim against the other party and against the
Ground Lessor. The parties agree to use reasonable efforts to insure that their policies will include such waiver clause or endorsement. 
  
 Section 16.02 - Waiver of Rights. Landlord and Tenant each waive all claims, causes of action and rights of recovery against the other and
against the Ground Lessor and their respective partners, agents, officers and employees, for any loss or damage to persons, property or business which occurs on or about the Premises or the Building and results from any of the perils insured under
any policy of insurance maintained by Landlord and/or Tenant, regardless of cause. This waiver includes the negligence and intentional wrongdoing of either party and their respective agents, officers and employees but is effective only to the extent
of recovery, if any, under any such policy. This waiver will be void to the extent that any such insurance is invalidated by reason of this waiver. 
  
 ARTICLE 17 
  
 Damage and Restoration 
  
 Section 17.01 - Substantial Damage. If the Building is damaged by fire or other casualty, Tenant agrees to give prompt written notice to Landlord. If as a result of fire or other casualty, (i) the
Building is so damaged that substantial alteration or reconstruction of the Building is, in Landlord’s sole opinion, required (whether or not the Premises have been damaged), or (ii) the Ground Lease is terminated, or (iii) any mortgagee of the
Building requires that all or a substantial portion of insurance proceeds payable be used to retire the mortgage debt, Landlord may, at its option, terminate this Lease by giving notice to Tenant within Sixty (60) days after the date of the damage.
If, within sixty (60) days after the date of the 

  

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damage, Landlord does not begin to restore the Building as provided in Section 17.02 or notify Tenant of its election to terminate this Lease, Tenant may
terminate this Lease by giving notice to Landlord within ten (10) days after this expiration of the sixty (60) days period. If this Lease is terminated by Landlord or Tenant as provided in this Section 17.01, Rent will be abated as of the date of
the damage. 
  
 Section 17.02 - Restoration. If
Landlord does not terminate this Lease as provided in Section 17.01 within sixty (60) days after the date of the damage, Landlord agrees to begin to restore the Building to substantially the same condition in which it was immediately before the
damage, and, subject to Unavoidable Delays, to continue the restoration with reasonable diligence. Landlord’s restoration work will include Landlord’s Fixtures, the scope of the work done by Landlord in originally finishing the Premises
according to the Working Drawings and subsequent Improvements made by Tenant under the provisions of Section 7.06 which are to remain part of the Premises. Landlord will not be required to rebuild, repair, or replace (i) any part of Tenant’s
furniture, furnishings or equipment, or (ii) any Improvements made by Tenant which Tenant is required to remove on the Lease Termination Date under Section 7.06. Landlord will not be liable for any inconvenience or annoyance to Tenant or injury to
the business of Tenant resulting from the damage to or the repair of the Building, except that Landlord will allow Tenant a fair reduction of Rent to the occurrence of the damage to a date thirty (30) days after completion of Landlord’s
repairs. 
  
 ARTICLE 18 
  
 Eminent Domain 
  
 Section 18.01 - Total Taking. If there is a Total Taking, then
this Lease will terminate as of the earlier to occur of (i) the date when physical possession of the Building or the Premises is taken by the condemning Governmental Authority or (ii) the date when title vests in the condemning Governmental
Authority. 
  
 Section 18.02 - Partial Taking. If
there is a Taking of the Premises which is not a Total Taking, Landlord may terminate this Lease by giving notice to Tenant within sixty (60) days after receiving notice of the Taking, in which event this Lease will terminate as of the earlier to
occur of (i) the date when physical possession of such portion of the Premises is taken by the condemning Governmental Authority or (ii) the date when title vests in the condemning Governmental Authority. If this Lease is not terminated, Rent will
be abated from the date the Premises are rendered unfit for occupancy by an amount representing that part of the Rent properly allocable to the portion of the Premises taken, and Landlord will, at Landlord’s expense, restore the 

  

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Building and the Premises to substantially their former condition to the extent that restoration, in Landlord’s judgment, may be feasible.
Landlord’s restoration work will not exceed the scope of Tenant Fit-up as shown in the Working Drawings and subsequent Improvements made by Tenant under the provisions of Section 7.06 which are to remain part of the Premises. 
  
 Section 18.03 - Awards and Proceeds. All proceeds payable in
respect of a Taking will be the property of Landlord. Tenant hereby assigns to Landlord all rights of Tenant in or to such awards and proceeds, provided that Tenant will be entitled to separately petition the condemning authority for a separate
award for its moving expenses and trade fixtures but only if such a separate award will not diminish the amount of award or proceeds payable to Landlord. 
  
 ARTICLE 19 
  
 Quiet Enjoyment 
  
 Section 19.01 - Landlord’s Covenant. Landlord covenants that it has good title to the Premises and the Common Areas, subject to the Permitted Exceptions, and that it has sufficient authority to
enter into this Lease. Landlord also covenants that if Tenant pays the Rent and performs all of its obligations under this Lease, subject to the Permitted Exceptions, it will quietly have and enjoy the Premises during the Lease Term, without
interference from any Person lawfully claiming under Landlord or by paramount title. Landlord agrees that it will pay and perform all of its obligations under the Ground Lease. 
  
 Section 19.02 - Subordination and Non-Disturbance. This Lease is subordinate to (i) the Ground Lease and (ii)
any mortgage now or hereafter on the building and to each advance made under any such mortgage, and to all renewals, modifications, consolidations, replacements and extensions of such mortgage. This Section 19.02 is self-operative and no further
instrument of Subordination will be required, provided that before a future subordination is effective Landlord will cause the mortgagee or Ground Lessor to deliver to Tenant an non-disturbance agreement, binding upon itself and any successor in
interest, to the effect that no foreclouser of the mortgage or termination of the Ground Lease will disturb the possession of Tenant under this Lease so long as on Event of Default exists. In confirmation of such subordination, Tenant agrees to
execute and deliver promptly any certificate that Landlord or the Ground Lessor or any mortgagee may request. If any mortgagee or Ground Lessor succeeds to the interest of Landlord and agrees to recognize the interest of Tenant under this Lease,
Tenant agrees to attorn to such mortgagee or Ground Lessor and to recognize such mortgagee or Ground lessor as its Landlord. 
  

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 Section 19.03 - Notice to Mortgage and Ground Lessor. No act or failure to act on the part
of Landlord which would entitle Tenant under the terms of this Lease, or by Law, to be relieved of Tenant’s obligations under or to terminate this Lease, will result in a release or termination of such obligations or a termination of this Lease
unless (i) Tenant first gives written notice of Landlord’s act or failure to act to Landlord’s first mortgagee of record, if any, and to the Ground Lessor specifying the act or failure to act on the part of Landlord which could or would
give basis to Tenant’s rights; and (ii) the mortgagee or Ground Lessor, after receipt of such notice, fails or refuses to correct or cure the condition complained of within a reasonable time. Nothing contained in this Section 19.03 will be
deemed to impose any obligation on any mortgagee or Ground Lessor to correct or cure any condition. “Reasonable time” means a period of not less than thirty (30) Business Days and includes (but is not limited to ) a reasonable time to
obtain possession of the Building if the mortgagee or Ground Lessor elects to do so and a reasonable time to correct or cure the condition if the condition is determined to exist. Tenant has no obligation to give notice under this Section 19.03
until the mortgagee or the Ground Lessor has given Tenant notice of its interest as such and the address to which notices under this Section 19.03 are to be sent. 
  
 Section 19.04 - Other Provisions Regarding Mortgagees. If this Lease or the Rent is assigned to a mortgagee as
collateral security for any obligation, the mortgagee will not be deemed to have assumed any of Landlord’s obligations under this Lease solely as a result of the assignment. A mortgagee to whom this Lease has been assigned will be deemed to
have assumed such obligations only if (i) by the terms of the assignment the mortgagee specifically elects to assume the obligations, or (ii) the mortgagee has (a) foreclosed its mortgage, (b) accepted a deed in substitution of foreclosure, or (c)
taken possession of the Premises. Even if the mortgagee assumes the obligations of Landlord, the mortgagee will be liable for breaches of any of Landlord’s obligations only to the extent the breaches occur during the period of ownership by the
mortgagee after foreclosure ( or any conveyance by a deed in substitution of foreclosure) or after entry, and the mortgagee will have no liability for any act or omission or for any obligations incurred by any prior Landlord, including liability
with respect to any Security Deposit except to the extent actually received by such mortgagee. 
  
 ARTICLE 20 
  
 Defaults; Events of Default 
  
 Section 20.1 - Defaults. The following will (i) if any requirement for notice or lapse of time has not been met, constitute Defaults, and (ii) if there are no such requirements or if such requirements have been met, constitute
Events of Default: 
  
 (a) The failure of Tenant
to pay Rent when due, and the continuation of the failure for a period of ten (10) days after notice from Landlord specifying the failure; 
  

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 (b) The failure of Tenant to perform any of its obligations under this Lease, other than
its obligation to pay Rent, and the continuation of the failure for a period of twenty (20) days after notice from Landlord specifying in reasonable detail the nature of the failure; 
  
 (c) The failure of Tenant to pay Rent when due or to perform any of its obligations under this Lease, if
Landlord has given Tenant notice of the same or similar failure at least twice during the twelve (12) month period preceding the date on which the Rent or performance was due. 
  
 (d) The occurrence with respect to Tenant or any Guarantor of one or more of the following events: the
death, dissolution, termination of existence (other than by merger or consolidation), insolvency, appointment of a receiver for all or substantially all of its property, the making of a fraudulent conveyance or the execution of an assignment or
trust mortgage for the benefit of creditors by it, or the filing of a petition of bankruptcy or the commencement of any proceedings by or against it under a bankruptcy, insolvency or other law relating to the relief or the adjustment of
indebtedness, rehabilitation or reorganization of debtors; provided that if such petition or commencement is involuntarily made against it and is dismissed within sixty (60) days of the date of such filing or commencement, such events will not
constitute an Event of Default; 
  
 (e) The
issuance of any execution or attachment against Tenant or any other occupant of the Premises as a result of which the Premises are taken or occupied by a Person other than Tenant; and 
  
 (f) The cancellation of, refusal to review or denial of liability under any insurance policy relating to the
Premises as a result of the Premises being unoccupied. 
  
 Section 20.2 - Tenant’s Best Efforts. If the Default of which Landlord gives notice is of such a nature that it cannot be cured within twenty (20) days, then the Default will not be deemed to continue so long as Tenant,
after receiving notice of the Default, begins to cure the Default as soon as reasonably possible and continues to take all steps necessary to complete the curing of the Default within time which, under all prevailing circumstances, is reasonable. No
Default will be deemed to continue so long as Tenant is acting to cure the Default in good faith or is delayed in or prevented from curing the Default by reason of Unavoidable Delays. 
  

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 ARTICLE 21 

 
 Landlord’s Remedies; Damages on Default 
  
 Section 21.01 - Landlord’s Remedies. Landlord may, at its
option: 
  
 (a) Whenever an Event of Default
exists, give Tenant a notice terminating this Lease on a date specified in the notice. On the date specified in the notice, this Lease and all rights of Tenant under this Lease will end without further notice or lapse of time, but Tenant will
continue to be liable to Landlord as provided in this Article 21. 
  
 (b) If an Event of Default results from Tenant’s failure to pay Tenant’s Cost as required by Section 7.01 and the Work Letter, in addition to or in substitution of the other remedies available to Landlord,
refuse Tenant access to the Premises. In such event the Term Commencement Date will be the earlier of (i) the date determined under Section 7.04 or (ii) the Substantial Completion Date. 
  
 (c) If an Event of Default results from Tenant’s failure to pay a charge for Additional Services,
without further notice to Tenant, discontinue any or all Additional Services. 
  
 Section 21.02 - Possession. Upon termination of this Lease as the result of an Event of Default, Tenant agrees to leave the Premises peacefully and surrender possession to Landlord as provided in Section
9.08. Landlord may, at any time after any termination of this Lease and without further notice, enter the Premises and recover possession by summary proceedings or any other manner permitted by law, and may remove Tenant and all other Persons and
property from the Premises. After termination of this Lease, Landlord will be entitled to receive all rental income from the Premises. 
  
 Section 21.03 - Right to Relet. After termination of this Lease as a result of an Event of Default, Landlord may relet all or any part of
the Premises in the name of Landlord or otherwise, for such term (which may be greater or less than the period which would have constituted the balance of the Lease Term) and on such conditions (which may include concessions or free rent) as
Landlord, in its reasonable discretion, may determine. Landlord agrees to use reasonable efforts but will not be liable for failure to relet the Premises or for failure to collect any rent due upon reletting, and Landlord will not be obligated to
show the Premises in preference to other space available in the Building. 
  

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 Section 21.04 - Survival of Covenants, Etc. If this Lease is terminated as provided in
Section 21.01: 
  
 (a) The termination will not
relieve Tenant of its obligations under this Lease, which obligations will survive the termination. Tenant agrees to indemnify Landlord against all claims, losses and expenses arising out of the termination. 
  
 (b) At the time of termination, Tenant agrees to pay to
Landlord the Rent up to the date of termination. Tenant also agrees to pay to Landlord, on demand, as liquidated damages for Tenant’s Default, the excess of 
  
 (1) the total Rent that would have been payable under this Lease by Tenant from the date of the termination
until the Stated Expiration Date, over 
  
 (2) the fair and reasonable rental value of the Premises for the same period reduced by Landlord’s reasonable estimate of expenses to be incurred in connection with reletting the Premises, including, without limitation, all
repossession costs, brokerage commissions, legal expenses, reasonable attorneys’ fees, alteration costs, and expenses of preparation for reletting. 
  
 (c) If all or part of the Premises are relet by Landlord, before presentation of proof of such liquidated damages to any court, commission
or tribunal, the amount of rent reserved upon the reletting will be, prima facie, the fair and reasonable rental value for the part or the whole of the Premises relet during the term of the reletting. 
  
 (d) Nothing contained in this Section 21.04 will limit or
prejudice the right of Landlord to prove and obtain as liquidated damages by reason of the termination, an amount equal to the maximum allowed by any statute or rule of law in effect at the time when, and governing the proceedings in which, such
damages are to be proved, whether or not such amount is greater, equal to, or less than the amount determined as provided in clause (b) above. 
  
 Section 21.05 - Right to Equitable Relief. If a Default occurs, Landlord will be entitled to enjoin the Default and may invoke any remedy
allowed at law or in equity as though re-entry, summary proceedings and other remedies were not provided for in this Lease. 
  
 Section 21.06 - Right to Self Help; Interest On Overdue Rent. If an Event of Default occurs, Landlord has the right, but not the obligation,
to enter the Premises and to perform any obligation of Tenant under this Lease notwithstanding the fact that no specific provision for substituted performance by Landlord is made in this Lease. In performing the obligation, Landlord may make any
payment of money or perform any other act. The total of (i) all 

  

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sums paid by Landlord (ii) interest (at the rate of 1-1/2 % per month or the highest rate permitted by law, whichever is less) on such sums plus all Rent not
paid when due and (iii) all expenses in connection with the performance of the obligation by Landlord, will be deemed to the Rent under this Lease and payable to Landlord on demand. Landlord may exercise its rights under this Section 21.05 without
waiving any other of its rights or releasing Tenant from any of its obligations under this Lease. 
  
 ARTICLE 22 
  
 Notices 
  
 Section 22.01 - Notices
and Communications. All notices, demands, requests and other communications provided for or permitted under this Lease must be in writing and be delivered by hand or sent by telecopy, nationally recognized and reputable overnight delivery
service, express mail, certified mail or first-class mail, postage prepaid, to the parties, respectively at the following addresses: 
  
 (a) if to Landlord, at the address stated in Section 1.01 (or at such other address as Landlord designates in writing to Tenant), with a
copy to such Persons as Landlord designates in writing to Tenant, or 
  
 (b) if to Tenant, at the address stated in Section 1.01 (or at such other address as Tenant designates in writing to Landlord), with a copy to such Persons as Tenant designates in writing to Landlord. 
  
 Section 22.02 - When Effective. Any communication provided for
in this Lease will become effective only when received or deemed received by the Person to whom it is given. If it is mailed by express, certified or first-class mail, it will be deemed to be received on (i) the second Business Day after being
mailed or (ii) the day of its receipt, whichever is earlier. If given by telecopy, it will be deemed received when confirmation of complete receipt is received by the transmitting person during normal business hours on a Business Day, or on the next
Business Day if confirmation is received after normal business hours. 
  
 ARTICLE 23 
  
 Waivers 
  
 Section 23.01 - No Waivers. Failure of Landlord or Tenant to
complain of any act or omission on the part of the other no matter how long the act or omission may continue, will not be deemed to be a waiver by either Landlord or Tenant at any time, expressed or implied, of the breach of any provision of this
Lease will be deemed a waiver of a breach of any other provision of this Lease or a consent to any subsequent breach of the same or any 

  

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other provision. No acceptance by Landlord of any partial payment will constitute an accord or satisfaction but will only be deemed a partial payment on
account. None of Tenant’s obligations under this Lease and no Default or Event of Default may be waived or modified except in writing by Landlord. 
  
 ARTICLE 24 
  
 Security Deposit 
  
 Section 24.01 - Security Deposit. Tenant has deposited with Landlord the Security Deposit in the amount, if any, stated in Section 1.01. Landlord will hold the Security Deposit as security for the
payment or performance by Tenant of its obligations under this Lease and not as a prepayment of Rent. Landlord may commingle the Security Deposit with other funds of Landlord. Landlord will not be liable to Tenant for the payment of interest.
Landlord may expend such amounts from the Security Deposit as may be necessary to cure any Default or Event of Default and, in such case, Tenant agrees to pay to Landlord the amount expended, on demand. Landlord may assign the Security Deposit to
any subsequent owner of the Building and thereafter Landlord will have no liability to Tenant with respect to the Security Deposit. As soon as reasonably practicable after the Lease Termination Date, Landlord agrees (i) to inspect the Premises, (ii)
to make such payments from the Security Deposit as may be required to reimburse itself for unpaid Rent and all expenses arising out of the termination of the Lease and reletting the Premises and (iii) if no Default or Event of Default has occurred
or exists, pay the balance of the Security Deposit to Tenant. 
  
 ARTICLE 25 
  
 General Provisions

  
 Section 25.01 - Unavoidable Delays. If
Landlord or Tenant is delayed, hindered in or prevented from the performance of any act required under this Lease by reason of Unavoidable Delays, then performance of the act will be excused for the period of the delay and the period for the
performance of the act will be extended for a period equivalent to the period of the delay. 
  
 Section 25.02 - Estoppel Certificates. Tenant agrees to deliver to Landlord within five (5) Business Days after the Term Commencement Date an estoppel certificate substantially in the form of Exhibit
D. Within five (5) Business Days after receipt of a request from Landlord, Tenant agrees to deliver to any prospective purchaser, mortgagee or other Person specified in the request an estoppel certificate substantially in the form of Exhibit
D or in such other form as the purchaser, mortgagee or other Person may reasonably prescribe. Each estoppel certificate 

  

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Will be (i) signed by a duly authorized representative of Tenant, (ii) delivered without charge to the party requesting it and (iii) binding as to its
contents on Tenant. 
  
 Section 25.03 – Right to
Relocate.* Landlord may, at its option, upon not less than six (6) months prior notice to Tenant, relocate Tenant (effective as of the date specified in the notice) to other space in the Building or in another building in the Park having
Improvements comparable in type, quality and quantity, a substantially similar configuration and a rentable area approximately the same as the Premises. Landlord agrees to place the other space in substantially the same condition as the Premises are
then in and to pay all costs associated with the relocation. If Tenant is relocated under this provision (i) the other space will be substituted for the Premises under this Lease (ii) the terms and provisions of this Lease will remain in full force
and effect and (iii) Tenant agrees (a) to relocate as requested by Landlord and (b) to execute all documents (including but not limited to a termination or amendment of this Lease with respect to the Premises) as Landlord may reasonably request.

  
 Section 25.04 - Holding Over. If Tenant occupies
the Premises after the Lease Termination Date without having entered into a new lease of the Premises with Landlord, Tenant will be a tenant-at-sufferance only, subject to all of the provisions of this Lease at twice the then effective Basic Rent.
Such holding over, even if with the consent of Landlord, will not constitute an extension or renewal of this Lease. 
  
 Section 25.05 - Governing Law. This Lease and the performance of its provisions will be governed and construed under the laws of the
Commonwealth of Massachusetts. 
  
 Section 25.06 –
Partial Invalidity. If any provision of this Lease or its application to any Person or circumstance is held to be invalid or unenforceable, the remainder of this Lease, or the application of the provision to Persons or circumstances other
than those as to which it is held invalid or unenforceable, will not be affected, and each provision of this Lease will be enforced to the fullest extent permitted by law. 
  
 Section 25.07 - Notice of Lease. At the request of either one, Landlord and Tenant agree to execute promptly
duplicate originals of a statutory notice of lease, in recordable form, setting forth a description of the Premises, the Lease Term and any other terms of this Lease, except the rental provisions, as may be required by law or as either party may
request. 
  
 Section 25.08 - Interpretation. The
section headings used in this Lease are for reference and convenience only, and do not enter into the interpretation of this Lease. This Lease may be signed in several counterparts, each of which is an original, but all of which constitute a single
instrument. The term “Landlord” means only the owner at the time of the Building. Upon any sale of the Building or assignment (other than as collateral security for an obligation) of the interest of Landlord in this Lease, 
  

	*	See Rider and Addendum - 8 

  

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 Landlord will be relieved of all liability under this Lease and its successor in interest and/or assign will be deemed to
be Landlord so long as it owns the Building. The liability of Landlord under this Lease is limited to Landlord’s interest in the Building. 
  
 Section 25.09 - Consents. * Except for the consents of Landlord required under Section 7.06 and Article 13, consents or approvals required
or requested of either Landlord or Tenant shall not be unreasonably withheld or delayed. 
  
 Section 25.10 - Entire Agreement; Changes. All prior agreements between the parties are merged within this Lease, which alone fully states the entire understanding and agreement of the parties. This
Lease may not be changed or terminated orally or in any manner other than by an agreement in writing and signed by the party against whom enforcement of the change or termination is sought. 
  
 Section 25.11 - Binding Effect. The provisions of this Lease
are binding on and inure to the benefit of Landlord, its successors and assigns, and Tenant, its successors and assigns and any Person claiming under Tenant. 
  
 Section 25.12 - Time of Essence. Any provision of law or equity to the contrary notwithstanding, it is agreed that time is of the essence of
this Lease. 
  
 Section 25.13 - Table of Contents.
The table of contents preceding this Lease but under the same cover is for the purpose of convenience and reference only and is not to be deemed or construed in any way as part of this Lease. 
  
 EXECUTED as a sealed instrument as of the Date of Lease specified in Section
1.01. 
  

			
	LANDLORD:
	
	WORCESTER BUSINESS DEVELOPMENT CORPORATION
		
	By:	 	/s/ M. Hart
	 	 	 Chairman

	
	TENANT:
	
	UNISYN TECHNOLOGIES, INC.
		
	By:	 	 


  

	*	See Rider and Addendum - 11 

  

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 EXHIBIT A 

 
 LANDLORD’S SERVICES 
  

	I.	CLEANING 

  

	 	A.	General 

  
 1. All cleaning work will be performed during non-business hours, Monday through Friday, unless otherwise necessary for stripping, waxing,
etc. 
  
 2. Abnormal waste removal (e.g.,
computer installation paper, bulk packaging, wood or cardboard crates, refuse from cafeteria operation, etc.) will be Tenant’s responsibility. 
  

	 	B.	Daily Operations (on Business days only) 

  

	 	1.	Tenant Areas 

  

	 	a.	Empty and clean all waste receptacles; wash receptacles as necessary. 

  

	 	b.	Vacuum all rugs and carpeted areas. 

  

	 	c.	Empty, damp-wipe and dry all ashtrays. 

  

	 	2.	Lavatories 

  

	 	a.	Sweep and wash floors with disinfectant. 

  

	 	b.	Wash both sides of toilet seats with disinfectant. 

  

	 	c.	Wash all mirrors, basins, bowls, urinals. 

  

	 	d.	Spot clean toilet partitions. 

  

	 	e.	Empty and disinfect sanitary napkin disposal receptacles. 

  

	 	f.	Refill toilet tissue, towel, soap, and sanitary napkin dispensers. 

  

	 	3.	Public Common Areas 

  

	 	a.	Wipe down entrance doors and clean glass (interior and exterior). 

  

	 	b.	Vacuum elevator carpets and wipe down doors and walls. 

  

	 	c.	Clean water coolers. 

  

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	 	C.	Operations as Needed (bur not less than every other day) 

  

	 	1.	Tenant and Public Common Areas 

  

	 	a.	Buff all resilient tile floor areas. 

  

	 	D.	Weekly Operations 

  

	 	1.	Tenant Areas, Lavatories, Public Common Areas 

  

	 	a.	Hand-dust and wipe clean all horizontal surfaces within normal reach with treated cloths (including furniture, office equipment, windowsills, Venetian blinds, door ledges, chair
rails, baseboards, etc.). 

  

	 	b.	Sweep all stairways. 

  

	 	E.	Monthly Operations 

  

	 	1.	Tenant and Public Common Areas 

  

	 	a.	Thoroughly vacuum seat cushions on chairs, sofas, etc. 

  

	 	b.	Vacuum and dust grillwork. 

  

	 	2.	Lavatories 

  

	 	a.	wash down interior walls and toilet partitions. 

  

	 	F.	As Required and Weather Permitting 

  

	 	1.	Entire Building 

  

	 	a.	Clean inside of all windows. 

  

	 	b.	Clean outside of all windows. 

  

	 	G.	Yearly 

  

	 	1.	Tenant and Common Areas 

  

	 	a.	Strip and wax all resilient tile floor areas. 

  

	II.	HEATING, VENTILATING, AND AIR CONDITIONING 

  
 1. Heating, ventilating, and air conditioning (“HVAC”) as required to provide reasonably comfortable temperatures for normal
occupancy at all times. 
  
 2. Maintenance of any
additional or special air conditioning equipment and the associated operating cost will be at Tenant’s expense. 
  

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	III.	WATER AND WASTE 

  
 Hot water for lavatory purposes and cold water for drinking, lavatory and toilet purposes. Liquid laboratory and sanitary waste disposal and maintenance
of related plumbing systems. 
  

	IV.	ELEVATORS 

  
 Elevators for the use of all tenants and the general public for access to and from all floors of the Building. Programming of elevators (including, but
not limited to, service elevators) will be as Landlord, from time to time, determines best for the Building as a whole. 
  

	V.	RELAMPING OF LIGHT FIXTURES 

  
 Tenant will reimburse Landlord for the cost of replacement lamps, ballasts and starters within the Premises. 
  

	VI.	CAFETERIA AND VENDING INSTALLATIONS 

  
 1. Any space to be used primarily for lunchroom or cafeteria operation within the Premises will be Tenant’s responsibility to keep
clean and sanitary, it being understood that Landlord’s approval of such use must be first obtained in writing. 
  
 2. Vending machines or refreshment service installations by Tenant must be approved by Landlord in writing and will be restricted to use
by employees and business invitees. All cleaning necessitated by such installations shall be at Tenant’s expense. 
  

	VII.	STRUCTURAL AND EXTERIOR MAINTENANCE 

  
 Landlord will maintain the Building (excluding the Premises and other tenant areas but including structural components, roof, exterior and foundation,
elevators, HVAC, pipes, wires and other building systems, common areas, parking areas, sidewalks and access areas, etc.) in good condition and working order. Landlord will remove snow and maintain landscaped areas of the Land as necessary.

  

	VIII. 	SECURITY 

  
 Landlord will control access to the Building during non-business hours through use of a card access system or equivalent. 
  

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 [GRAPHIC APPEARS HERE] 
  

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 EXHIBIT C 

 
 WORK LETTER 
  
 This Work Letter is attached to and incorporated by reference into a Lease
(the “Lease”) of the Premises in the Building known as Four Biotech Park between WORCESTER BUSINESS DEVELOPMENT CORPORATION (“Landlord”) and UNISYN TECHNOLOGIES, INC. (“Tenant”). Terms in this Work Letter
not otherwise defined have the same meanings as in the Lease. 
  

	 	1.	The provisions of Sections 7.01, 7.02, 7.03, 7.04, 7.05 and 7.06 of the Lease are made part of this Work Letter. 

  

	 	2.	In preparing the Premises for initial occupancy by Tenant, Landlord will provide the space as it exists on the Date of Lease (“Landlord’s Work”). In the Common Areas,
Landlord’s Work includes entrances, main corridor, elevators and lavatory facilities. 

  

	 	3.	At least ten (10) days before the Design Start Date, Landlord will give Tenant a list of information required by Landlord’s architect to prepare a schematic space plan of the
Premises (“Space Plan”). Tenant agrees to meet with Landlord and its architect on or before the Design Start Date and deliver all information necessary to prepare the Space Plan. 

  

	 	4.	Within fifteen (15) days after the Design Start Date, or the date on which Tenant delivers the necessary information, if later, Landlord will deliver to Tenant a copy of the Space
Plan and an estimate of Tenant’s Cost for the work shown on the Space Plan. Within seven (7) days after receipt of the Space Plan and estimate, Tenant will confirm to Landlord that they are approved or give Landlord a detailed explanation of
why they are unacceptable. Landlord and Tenant agree to repeat the procedure outlined in this paragraph 4 until Tenant approves both the Space Plan and the estimate of Tenant’s Cost. 

  

	 	5.	Within thirty (30) days after approval by Tenant of the Space Plan and estimate of Tenant’s Cost, Landlord will deliver to Tenant the Working Drawings prepared by
Landlord’s architect. The cost of preparing the Working Drawings and any subsequent changes requested by Tenant will be included in Tenant’s Cost. 

  

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	 	6.	Within seven (7) days after receipt by Tenant of the Working Drawings, Tenant will notify Landlord either (i) that the Working Drawings correctly depict the proper layout and design
of all Tenant Fit-up desired by Tenant and Tenant approves the Working Drawings, or (ii) that the Working Drawings vary in design from the approved Space Plan, in which case Landlord will correct the Working Drawings, or (iii) that Tenant wishes to
modify the Working Drawings, in which case Tenant will include with the notification to Landlord a written list of modifications to the Working Drawings. 

  

	 	7.	Promptly upon receipt of Tenant’s approval of the Working Drawings, Landlord agrees to obtain from a qualified contractor a guaranteed maximum price to construct Tenant Fit-up
as shown in the Working Drawings, and to submit to Tenant the final Tenant’s Cost together with a schedule for completion of the work. If Tenant’s Cost, as finally determined, does not exceed Landlord’s estimate by more than ten
percent (10%), Tenant agrees to accept the final determination and authorizes Landlord to proceed with construction of Tenant Fit-up. If Tenant’s Cost exceeds Landlord’s estimate by more than ten percent (10%), the process outlined in
paragraph 6 above will be repeated until Tenant approves Tenant’s Cost. 

  

	 	8.	If Tenant’s Cost exceeds the amount of any allowance agreed to by Landlord, within seven (7) days after the final determination of Tenant’s Cost, Tenant agrees (i) to
deposit an amount equal to that excess in an escrow account which provides for the payment of Tenant’s Cost on terms satisfactory to Landlord, or at Landlord’s option, (ii) to make other arrangements acceptable to Landlord for the payment
of the excess. Landlord will be under no obligation to begin construction of Tenant Fit-up until Tenant has complied with the provisions of this paragraph. 

  

	 	9.	Tenant may request changes in Tenant Fit-up after approval of the Working Drawings and Tenant’s Cost, Changes to the Working Drawings and the work made by Tenant will be priced
at the cost of (i) making such changes to the Working Drawings and (ii) the cost of the work shown thereon (including any contractor’s overhead profit and general conditions). Tenant agrees to pay the cost of all changes made by it.


  

	 	10.	Landlord may rely on Tenant’s representative with respect to all matters which pertain to this Work Letter, Tenant having authorized Tenant’s representative to make
decisions binding upon Tenant with respect to such matters. 

  

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	 	11.	If Landlord exercises its right to terminate this Lease because of Tenant’s failure to perform any of its obligations, including its obligations under this Work Letter, and if
the termination occurs before the Term Commencement Date, Tenant agrees to pay Landlord, as Additional Rent, (i) an amount equal to the sum of all expenses incurred by Landlord for architectural, engineering, consulting, legal and other professional
services relating to the Premises and this Lease, plus (ii) Basic Rent for the period from the date Tenant accepted Landlord’s letter of intent to lease the Premises through the Lease Termination Date. 

  

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 EXHIBIT D 

 
 ESTOPPEL CERTIFICATE 
  
                     , 19     
  
 Gentlemen: 
  
 Reference is made to the Lease dated                     , 19    , from WORCESTER BUSINESS
DEVELOPMENT CORPORATION, as Landlord to
                                        , as
Tenant with respect to the Premises in the Building known as Four Biotech Park (the “Lease”). Terms used in this Certificate which are defined in or by reference to the Lease have the same meanings in this Certificate as in the Lease.

  
 The undersigned hereby ratifies the Lease and certifies that:

  

	 	1.	The Term Commencement Date is                     . 

  

	 	2.	The Stated Expiration Date is                     . 

  

	 	3.	The Premises are presently occupied by                     .


  

	 	4.	Basic Rent is currently payable at the rate of $             per year. 

  

	 	5.	Basic Rent has been paid through                     ,
19    . 

  

	 	6.	Additional Rent for Taxes and Operating Expenses had been paid through
                    , 19    . 

  

	 	7.	The Lease is in full force and effect and has not been assigned, modified, supplemented or amended in any way (except by agreement (s) dated
                     ) and represents the entire agreement between Landlord and Tenant. 

  

	 	8.	No Default or Event of Default has been asserted by either party to the Lease and, to the knowledge of the undersigned, no Default or Event of Default exists on the part of either
party to the Lease (except              ). 

  

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                     , 19     
 Page 2 
  

	 	9.	On this date, to the knowledge of the undersigned, there are no existing defenses or offsets which Tenant has against the enforcement of the Lease by the Landlord (except
                    ). 

  

	 	10.	No Rent has been paid in advance of its due date under the Lease. 

  

					
	Very truly yours,
	
	 
			
	By:	 	 	 	(Title)


  

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 EXHIBIT E 

 
 RENT RIDER 
  
 This Rent Rider is attached to and incorporated by reference into a Lease
(the “Lease”) of the Premises in the Building known as Four Biotech Park between WORCESTER BUSINESS DEVELOPMENT CORPORATION (“ Landlord”) and UNISYN TECHNOLOGIES, INC. (“Tenant”). Terms not
otherwise defined have the same meanings in this Rent Rider as in the Lease. 
  
 1. Definitions. Each term set forth in this paragraph 1 has the meaning stated immediately after it. 
  
 Basic Rent. During the first Fixed Rental Period Basic Rent will be the sum of the following amounts: 
  

	 	(a)	For Area A, the sum of (i) $21.00 per square foot of rentable area of Area A, plus (ii) an amount determined by multiplying that portion of Tenant’s Allowance (as defined in
the Rider and Addendum) advanced by Landlord on account of Area A by 17% and dividing the product by the rentable area of Area A; 

  

	 	(b)	For Areas B and C, the sum of (i) $9.00 per square foot of the rentable area of Areas B and C, plus (ii) and amount determined by multiplying that portion of Tenant’s Allowance
advanced by Landlord on account of Areas B and C by 17% and dividing the product by the rentable area of Areas B and C. 

  
 Basic Rent will be increased effective as of the first day of the month following the date on which Landlord makes any advance on account
of Tenant’s Allowance. 
  
 C.P.I.
“Consumer Price Index – All Urban Consumers (CPI-U) – U.S. City Average—All Items (1982-84 = 100)” as published by the U.S. Department of Labor. 
  
 Market Rent. The rent per square foot per year which a Person not affiliated with either Landlord or
Tenant would pay as Basic Rent as of the time of determination (i) for the same number of square feet Rentable Area as the Premises, located in the Building (or a comparable building comparably located), (ii) assuming similar terms and concessions,
if any, to those prevailing at the time, (iii) for a term of years equal to that for which the determination is being made and (iv) for space which is finished in a manner similar to that of the Premises. For purposes of determining Market Rent,
space in the Park leased to tax-exempt organizations or tenants sponsored by Commonwealth BioVentures, Inc. will not be considered comparable. All Additional Rent, such as Taxes and Operating Expenses, will be in addition to the rent per square foot
so determined. 
  

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 2. Adjustment of Basic Rent. Basic Rent for each Lease Year of each successive Fixed Rental
Period, if any, after the first Fixed Rental Period will be the greater of 
  

	 	(i)	an amount determined by (A) multiplying eighty percent (80%) of Basic Rent for the final Lease Year of the most recent Fixed Rental Period by a fraction, the numerator of which is
the C.P.I. for the last month or other reporting period of the most recent Fixed Rental Period and the denominator of which is the C.P.I. for the last month or other reporting period immediately preceding the Term Commencement Date, and (B) adding
the result to the remaining twenty percent (20%) of such Basic Rent; or 

  

	 	(ii)	an amount determined by increasing Basic Rent as stated in Article 1.01 by three percent (3%) per year, compounded annually for the period beginning on the Term Commencement Date
and ending on the last day of the most recent Fixed Rental Period. 

  
 Basic Rent determined as provided in this paragraph 2 will in no event be less than Basic Rent for each Lease Year of the preceding Fixed Rental Period and will be exclusive of (and in addition to) amounts due for
Taxes and Operating Expenses. 
  
 3. Change in C.P.I.;
Substituted Index. If the United States Department of Labor changes the base reference period for determining the C.P.I., the adjustment of Basic Rent will continue to be calculated with 1982-84 as the base reference period using such figures or
conversion formulas as the United States Department of Labor may publish at the time the base reference period is changed. If publication of the C.P.I. is discontinued, Landlord and Tenant agrees to accept comparable statistics on the cost of living
as they are computed and published by a Governmental Authority or if such statistics are not published by a Governmental Authority, comparable statistics published by a responsible financial periodical of recognized authority selected by Landlord.
If comparable statistics are used in place of the C.P.I., Landlord will make such reasonable revisions in the method of computation of Basic Rent as the circumstances may require to carry out the intent of this Rent Rider and will give Tenant notice
of the revisions before using them. 
  
 4. Market Rent;
Arbitration. 
  
 (a) At least ninety (90)
(but not earlier than one hundred twenty (120)) days before the end of each Fixed Rental Period, Landlord will notify Tenant of Landlord’s estimate of the Market Rent for the Premises. Landlord and Tenant will attempt to negotiate and determine
by agreement the Market Rent for the Premises. If a dispute arises between Landlord and Tenant with respect to the determination 

  

 – 46 – 








 
of Market Rent or if Landlord and Tenant have not agreed on such amount by the date which is sixty (60) days before the end of the then current Fixed Rental
Period, such dispute will be determined exclusively by the arbitrators appointed under this paragraph 4. 
  
 (b) If Market Rent is to be determined by the arbitrators, either Landlord or Tenant may give the other party a notice appointing an
arbitrator and demanding arbitration under this paragraph. Within fifteen (15) days after receipt of such notice, the other party will, by notice to the original party, appoint a second arbitrator on its behalf. If within thirty (30) days after the
appointment of the second arbitrator, the two arbitrators have not agreed upon the Market Rent, the two arbitrators will appoint a third and give notice of the appointment to each party. Each arbitrator must be a disinterested person of recognized
competence in the field of commercial real estate leasing. The three arbitrators will, as promptly as possible, determine the Market Rent, provided that 
  

	 	(i)	if the second arbitrator is not appointed in the manner prescribed, the first arbitrator may determine the matter alone; and 

  

	 	(ii)	if the two arbitrators appointed by the parties are unable to agree, within thirty (30) days after the appointment of the second arbitrator, upon the appointment of a third
arbitrator, they must give notice of such failure to agree to the parties, and, if the parties fail to agree upon the selection of such third arbitrator within fifteen (15) days after notice from the arbitrators, then the third arbitrator will be
the person appointed by the President of the Greater Worcester Board of Realtors, Inc., or if within fifteen (15) days the President fails to appoint an arbitrator, then within ten (10) days thereafter; either of the parties upon notice to the other
party may request such appointment by a judge of the Superior Court, Worcester Country, Commonwealth of Massachusetts, or of any other court having jurisdiction and exercising functions similar to those now exercised by the Superior Court.


  
 (c) Arbitration proceedings
will be conducted in Worcester in accordance with the rules of the American Arbitration Association then in effect, but only so far as consistent with the provisions of this paragraph 4. The arbitrators will be sworn to determine the questions at
issue faithfully and fairly. They will afford each party a hearing and the right to submit evidence with the privilege of cross examination on the questions at issue and will, with all possible speed, make their determination in writing and give the
parties written notice of their determination. If the first two arbitrators fail to decide, the third arbitrator shall make an independent determination of the Market Rent. 

  

 – 47 – 








 
The determination of each of the three arbitrators shall be submitted in writing to Landlord and Tenant. The Market Rent shall be the average of the two
closest determinations submitted by the Arbitrators and shall be final and binding on the parties. 
  
 (d) Landlord and Tenant will each be solely responsible for the payment of all fees and expenses of the arbitrator it appointed, and will
share equally the payment of all fees and expenses of the American Arbitration Association (if any) and of the third arbitrator. 
  

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 MASSACHUSETTS BIOTECHNOLOGY
RESEARCH PARK 
 SPACE LEASE 
 to

 UNISYN TECHNOLOGIES, INC. 
  
 RIDER AND ADDENDUM 
  
 The Space Lease from WORCESTER BUSINESS DEVELOPMENT CORPORATION to UNISYN TECHNOLOGIES, INC. to which this Rider and Addendum is attached is
amended by incorporation of the additional provisions contained in this Rider. If there is a conflict between the provisions of the Lease and this Rider, the provisions of this Rider will control. 
  
 1. The Premises and Basic Rent. Although the
Rentable Area of the Premises is 13,788 square feet, the premises will be subdivided into (3) areas called Area A, Area B, and Area C, and Tenant’s obligation to pay Basic Rent with respect to each of the Areas will begin when specified in this
paragraph, notwithstanding any other provision of the Lease to the contrary. The Design Start Date with respect to Area A and Area B is the date specified in Section 1.01. Landlord will have no obligation to begin preparation of Area C for
Tenant’s occupancy until Tenant gives Landlord a notice specifying the Design Start Date with respect to Area C. Subject to extension as a result of delays of the type described in Section 7.04, Landlord agrees that the Substantial Completion
Date with respect to Area C will occur not more than one hundred fifty (150) days after the Design Start Date of Area C. Irrespective of when the obligation to pay Basic Rent begins, Tenant’s obligation to pay Operating Expenses and Taxes for
the entire Premises will begin on the Term Commencement Date. 
  
 (a) Area A. Area A is located on the first floor of the Building substantially as shown on the Lease Plan and has a Rentable Area of 8,104 square feet. Area A will contain the cGMP facility and specialty chemical production suite.
Tenant’s obligation to pay Basic Rent with respect to Area A will begin on the Term Commencement Date. 
  
 (b) Area B. Area B is located on the first floor of the Building substantially as shown on the Lease Plan and has a Rentable Area of 1,280 square
feet. Area B will contain the offices, conference room and lunch room. Tenant’s obligation to pay Basic Rent with respect to Area B will begin on the Term Commencement Date. 
  
 (c) Area C. Area C is located on the first floor of the Building substantially as shown on the Lease Plan and has a
Rentable Area of 4,404 square feet. Tenant agrees to give Landlord notice of the Design Start Date with respect to Area C on or before October 31, 1996. Except for Unavoidable Delays or delays attributable solely to Landlord, and without regard to
the date on which Tenant gives notice of the Design Start Date with respect to Area C, Tenant’s obligation to pay Basic Rent with respect to Area C will begin on the earliest to occur of (i) the Substantial Completion Date with respect to Area
C, (ii) the date 

  

 – 49 – 








 
on which Tenant occupies Area C for the Permitted Use, or (iii) December 31, 1996. 
  
 2. Rentable Area of the Premises. Upon completion of Landlord’s work, the Rentable Area of the Premises
will be determined by Landlord by actual measurement and application of Landlord’s standard method for determining Rentable Area of building in the Park. Landlord agrees to give Tenant notice of the determination of Rentable Area of the
Premises together with a computation of the resulting adjustments, if any, in Basic Rent, Tenant’s Share and Initial Monthly Payment. 
  
 3. Tenant’s Allowance and Payment of Tenant’s Cost. Landlord agrees to make available up to $600,000 which Tenant may, at its
election use to pay Tenant’s Cost in preparing the Premises for Tenant’s occupancy, which amount is referred to in this Lease as “Tenant’s Allowance.” Tenant’s Allowance will consist of two separate funded accounts,
namely Account I in the amount of $400,000, which is applicable to Tenant’s Cost with respect to Area B and Area C, and Account II in the amount of $200,000, which is applicable to the entire Premises. Landlord’s obligation to make Account
I available will expire on October 31, 1996 unless on or before that date Tenant notifies Landlord of its intention to make Improvements and apply Account I to Tenant’s Cost for the Improvements. Tenant will have no right to request funds from
Account I after March 31, 1997. Landlord’s obligation to make Account II available is subject to the closing of permanent financing of the Building known as Three Biotech Park from Teachers Insurance and Annuity Association of America under a
commitment dated April 6, 1995. Tenant will have no right to request funds from Account II after June 30, 1996. 
  
 4. Operating Expenses. Notwithstanding the definition of “Operating Expenses” contained in Section 1.03, the maximum management
fees included in Operating Expenses in any Lease Year will not exceed six percent (6.00%) of Basic Rent. 
  
 5. Tenant’s Self-Help. Notwithstanding the limitations contained in Section 8.04, if Landlord fails to perform any of its
obligations as provided in this Lease, and the failure continues for a period of thirty (30) days after notice from Tenant, Tenant may perform those obligations specified in the notice, and Landlord agrees to reimburse Tenant for any costs incurred
by Tenant in performing those obligations. 
  
 6. Procedure
on Subletting. Notwithstanding the provisions of Section 13.02 to the contrary, if Tenant enters into an Occupancy Arrangement, Tenant agrees to pay to Landlord when received the excess, if any, of amounts received in respect of the
Occupancy Arrangement over the sum of (a) the Rent, plus (b) Tenant’s actual and reasonable out-of-pocket expenses incurred directly in connection with the creation of the Occupancy Arrangement, Plus (c) Tenant’s actual and reasonable
out-of-pocket expenses incurred in compliance with the provisions of Section 7.06 in preparing the Premises for the Occupancy Arrangement. If Tenant intends to enter into an Occupancy Arrangement for a period of two (2) years or less, and if more
than two (2) years remain in the Lease Term at the time the Occupancy Arrangement is to begin, 

  

 – 50 – 








 
Landlord will have no right to terminate this Lease with respect to so much of the Premises as is intended to be subject to the Occupancy Arrangement.

  
 7. Tenant’s Indemnity. Notwithstanding the
provisions of Section 14.03 to the contrary, and except to the extent waived by Tenant under the provisions of Section 16.02, Landlord agrees to indemnify Tenant against all claims, losses and expenses, including reasonable attorneys’ fees,
which may be imposed upon or incurred by Tenant by reason of any of the following occurrences: 
  
 (a) any act or omission on the Premises by Landlord, its agents, contractors, licensees or invitees; 
  
 (b) any condition, operation, maintenance or management of
the Premises which exists exclusively as a result of an act or omission by Landlord, its agents, contractors, licensees or invitees; or 
  
 (c) any act or omission on the part of Landlord, or any of its agents, contractors, licensees or invitees, whether or not occurring on the
Premises. 
  
 8. Right to Relocate. Section 25.03
relating to Landlord’s right to relocate Tenant is deleted in its entirety. 
  
 9. Subordination and Non-Disturbance. At the request of Tenant, Landlord agrees to use reasonable efforts to obtain a non-disturbance agreement from all existing ground lessors and mortgagees having an
interest in the Premises. 
  
 10. Expansion Space.
As used in this paragraph, the term “Expansion Space” means any space in the Building which, at any time during the Lease Term, is occupied by a Person other than Landlord under a written lease with Landlord, and the term
“Tenant’s Expansion Space” means Expansion Space which Tenant has elected to lease as provided in this paragraph. Landlord agrees to notify Tenant promptly after Landlord learns that any Expansion Space is or will become available.
Subject to the prior rights of other tenants to whom Landlord has granted substantially similar rights, Tenant has the option to lease any Expansion Space which Landlord notifies Tenant is or will become available. If Tenant gives Landlord notice of
its exercise of this option within thirty (30) days after notification from Landlord of the availability of the Expansion Space and if no Event of Default exists when Tenant’s notice is given, this Lease will be deemed to be amended to include
Tenant’s Expansion Space as part of the Premises for the remainder of the Lease Term upon all of the same terms contained in this Lease except that (i) the Rentable Area of the Premises will be amended to include Tenant’s Expansion Space;
(ii) Tenant’s Share will be increased to include the rentable area of Tenant’s Expansion Space; (iii) the Term Commencement Date with respect to Tenant’s Expansion Space will be the earlier of sixty (60) days after the date on which
Tenant’s Expansion Space becomes vacant and ready for occupancy (provided that date is at least sixty (60) days after Tenant exercises its option to lease the Expansion Space), or the date on which the Expansion Space is first occupied by
Tenant; (iv) if Tenant’s Expansion Space 

  

 – 51 – 








 
contains a rentable area of 10,000 square feet or more, and if there are less than three (3) Lease Years remaining in the Lease Term, the Lease Term will be
extended to include three (3) full years from the Term Commencement Date with respect to Tenant’s Expansion Space; and (v) subject to adjustment during each Fixed Rental Period as provided in Exhibit E, Basic Rent for each year of the remaining
Lease Term (as it may be extended) will be the greater of (a) the Basic Rent last paid by the Person most recently occupying Tenant’s Expansion Space or (b) Market Rent determined as provided in the Rent Rider attached as Exhibit E. If Tenant
exercises this option, Tenant’s Expansion Space will be leased to Tenant in its “as is” condition and Tenant will, at its expense and in compliance with the provisions of Section 7.06, design and construct all Improvements desired by
Tenant for its use and occupancy. Landlord and Tenant agree to execute such amendments to this Lease and other instruments as either of them considers necessary or desirable to reflect Tenant’s exercise of this option. 
  
 11. Consents. Notwithstanding the provisions of Section 25.09
to the contrary, Landlord will not unreasonably withhold consents of approvals under Section 13.02 if the business of the proposed occupant to be conducted on the Premises is in the biotechnology or biomedical research field and furthers the
purposes for which the park was created. 
  

 – 52 – 








  
 CLERK’S CERTIFICATE

  
 I, ____________________, hereby certify that I am the duly
elected and qualified Clerk/Assistant Clerk* of UNISYN TECHNOLOGIES, INC., a California corporation with a place of business in Milford, Massachusetts, and that the following vote was duly adopted by its Board of Directors: 
  

			
	“Voted:	 	That Peter __ ________
	 	 	(Name of officer or officers)
	 	 	President of
	 	 	(Office held)
	 	 	Unisyn Technologies, Inc. be and he hereby is, in the name and on behalf of the Corporation, authorized and directed to execute under seal and deliver a Lease with Worcester Business
Development Corporation, and in respect of the premises in the Massachusetts Biotechnology Research Park, located in Worcester, Massachusetts known as “Four Biotech Park,” upon all the terms, provisions and conditions set forth in said
Lease presented to the Directors; and the execution of the Lease by the President shall be conclusive evidence of the fact that the Lease signed by him was the one presented to and approved by the Directors.”

  
 I further certify that
the foregoing vote is in full force and effect. 
  

									
				
	 Dated: 10/05/95
	 	 	 	 Attest:
	 	 
	 	 	 	 	 	 	 	 	 Clerk/Assistant Clerk*

					
	 	 	 	 	 	 	 	 	 (SEAL)


  

 – 53 – 








 SECOND AMENDMENT TO LEASE 
  
 THIS SECOND AMENDMENT TO LEASE (“Amendment”) is made as of this 25th day of January, 2005, by and between
ARE-377 PLANTATION STREET, LLC, a Delaware limited liability company (“Landlord”) and BIO VEST INTERNATIONAL, INC., a Delaware corporation (“Tenant”). 
  
 RECITALS 
  
 A. Worcester Business Development Corporation, the predecessor-in-interest to Landlord, and Unisyn Technologies, Inc., the
predecessor-in-interest to Tenant, entered into that certain Space Lease dated as of October 26, 1995, as amended by that certain First Amendment to Lease dated August 7, 1996 (the “First Amendment”) (as amended, the “Lease”),
pursuant to the terms of which Tenant is leasing from Landlord certain space in the building located at 377 Plantation Street, Worcester, Massachusetts (the “Building”). All capitalized terms not otherwise defined herein shall have the
meanings given them in the Lease. 
  
 B. Landlord and Tenant
desire, subject to the terms and conditions set forth below, to amend the Lease in order to, among other things, provide for the addition of approximately 3,507 square feet to the Premises leased by Tenant under the Lease. 
  
 NOW, THEREFORE, in consideration of the covenants, conditions and agreements
contained herein, and of other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree as follows: 
  
 1. Description of Premises. Effective upon the full execution and delivery of this Amendment (the “Effective
Date”), the defined term “Premises” in Section 1.01 of the Lease is hereby amended to include the additional premises commonly known as Suite 120 in the Building, containing approximately 3,507 square feet, as depicted on
Exhibit A attached hereto (the “Additional Premises”). 
  
 2. Rentable Area of the Premises. Effective as of the Effective Date, the defined term “Rentable Area of the Premises” in Section 1.01 of the Lease is deleted in its entirety and replaced with
the following: 
  
 Rentable Area Of The Premises: 17,295
square feet 
  
 3. Tenant’s Share. Effective as of the
Effective Date, the defined term “Tenant’s Share” in Section 1.01 of the Lease is deleted in its entirety and replaced with the following. 
  

Tenant’s Share: 18.65% 
  
 4. Basic Rent. Effective as of the Effective Date, in addition to the Basic Rent payable by Tenant for the original 13,788 square feet of the
Premises, Tenant shall be required to pay Basic Rent for the Additional Premises in the amount of $24.00 per rentable square foot of the Additional Premises per year in equal monthly installments, on an absolute triple net basis. Notwithstanding
anything to the contrary contained herein, Tenant shall not be required to pay the first 2 installments of the monthly Basic Rent due for the Additional Premises. Payments for any fractional calendar month shall be prorated. 







 5. Condition of Additional Premises - Tenant Improvements. Effective as of the Effective Date,
Tenant shall accept the Additional Premises in their current “AS IS” condition, and without any representations and warranties of any kind by Landlord. Tenant agrees that any improvements or renovations to be made to the Additional
Premises shall be made at Tenant’s sole cost and expense, and subject to all of the provisions of the Lease. 
  
 6. First Amendment. Tenant has advised Landlord that the credit facilities described m the First Amendment are no longer in effect. Accordingly,
Landlord and Tenant acknowledge and agree that all of the provisions of the First Amendment no longer have any force or effect. 
  
 7. Surrender. On the Stated Expiration Date, Tenant shall surrender the Premises to Landlord free of Hazardous Substances brought upon, kept, used,
stored, handled, treated, generated in, or released or disposed of from, the Premises by any person other than Landlord (collectively, “Tenant HazMat Operations”) and released of all licenses or permits affecting the Premises and
any restrictions on the use of the Premises. At least 3 months prior to the surrender of the Premises, Tenant shall deliver to Landlord a narrative description of the actions proposed (or required by any governmental authority) to be taken by Tenant
in order to surrender the Premises on the State Expiration Date, free from any residual impact from the Tenant HazMat Operations and otherwise released for unrestricted use and occupancy (the “Surrender Plan”). Such Surrender Plan shall be
accompanied by a current listing of (i) all Hazardous Substances licenses and permits held by or on behalf of Tenant with respect to the Premises, and (ii) all Hazardous Substances used, stored, handled, treated, generated, released or disposed of
from the Premises, and shall be subject to the review and approval of Landlord’s environmental consultant. In connection with the review and approval of the Surrender Plan, upon the request of Landlord, Tenant shall deliver to Landlord or its
consultant such additional non-proprietary information concerning Tenant HazMat Operations as Landlord shall request. On or before such surrender, Tenant shall deliver to Landlord evidence that the approved Surrender Plan shall have been
satisfactorily completed and Landlord shall have the right, subject to reimbursement at Tenant’s expense as set forth below, to cause Landlords s environmental consultant to inspect the Premises and perform such additional procedures as may be
deemed reasonably necessary to confirm that the Premises are, as of the effective date of such surrender or early termination of the Lease, free from any residual impact from Tenant HazMat Operations. Tenant shall reimburse Landlord, as Additional
Rent, for the actual out-of pocket expense incurred by Landlord for Landlord’s environmental consultant to review and approve the Surrender Plan and to visit the Premises and verify’ satisfactory completion of the same, which cost shall
not exceed $5,000. Landlord shall have the unrestricted right to deliver such Surrender Plan and any report by Landlord’s environmental consultant with respect to the surrender of the Premises to third parties. 
  
 If Tenant shall fail to prepare or submit a Surrender Plan approved by
Landlord, or if Tenant shall fail to complete the approved Surrender Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail to adequately address any residual effect of Tenant HazMat Operations in, on or about the Premises,
Landlord shall have the right to take such actions as Landlord may deem reasonable or appropriate to assure that the Premises and the Project are surrendered free from any residual impact from Tenant HazMat Operations, the cost of which actions
shall be reimbursed by Tenant as Additional Rent. 
  

 2 








 8. Defaults. Effective as of the Effective Date, Section 20.1(a) of the Lease is deleted in its
entirety and replaced with the following: 
  
 a.
Tenant shall fail to pay any installment of Rent or any other payment hereunder when due; 
  
 9. Late Payments. Effective as of the Effective Date, Section 21.06(u) of the Lease is deleted in its entirety and replaced with the following: 
  
 “(ii) interest at the annual rate equal to 12% per annum or the highest rate permitted by law (the “Default
Rate”), whichever is less, on all Rent not paid when due and the sums described in clause (i) and” 
  
 In addition, late payment by Tenant to Landlord of Rent and other sums due will cause Landlord to incur costs not contemplated by this Lease, the exact
amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges and late charges which may be imposed on Landlord under any mortgage covering the Premises.
Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such payment is due, Tenant shall pay to Landlord an additional sum equal to 6% of the overdue Rent as a late charge. The parties agree
that this late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late payment by Tenant. In addition to the late charge, Rent not paid when due shall bear interest at the Default Rate from the 5th day
after the date due until paid. 
  
 10. Miscellaneous.

  
 a. This Amendment is the entire agreement
between the parties with respect to the subject matter hereof and supersedes all prior and contemporaneous oral and written agreements and discussions. This Amendment may be amended only by an agreement in writing, signed by the parties hereto.

  
 b. This Amendment is binding upon and shall
inure to the benefit of the parties hereto, their respective successors and assigns. 
  
 c. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person (collectively,
“Broker) in connection with this Amendment and that no Broker brought about the transaction evidenced by this Amendment. Landlord and Tenant each hereby agree to indemnify and hold the other harmless from and against any claims by any Broker
claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this Amendment. 
  
 d. This Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken
together shall constitute one and the same instrument. The signature page of any counterpart may be detached 

  

 3 








 
therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart identical thereto
except having additional signature pages executed by other parties to this Amendment attached thereto. 
  
 e. Except as amended and/or modified by this Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall
remain in full force and effect, unaltered and unchanged by this Amendment. Tenant acknowledges that Landlord is not currently in default of any obligation under the Lease. Except as expressly provided herein, the Lease remains unmodified and in
full force and effect. Any breach by Tenant of this Amendment shall constitute a breach and default by Tenant under the Lease. In the event of any conflict between the provisions of this Amendment and the provisions of the Lease, the provisions of
this Amendment shall prevail. Whether or not specifically amended by this Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Amendment. 
  
 [Signatures on the next page] 
  

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 IN WITNESS WHEREOF, Landlord and Tenant have each caused this Amendment to be duly executed, sealed and
delivered, by its duly authorized attorney in fact, as of the day and year first above written. 
  

					
	LANDLORD:
	
	ARE-377 PLANTATION STREET, LLC,
	 a Delaware limited liability company

		
	 By:
	 	 ARE-GP/IV HOLDINGS QRS CORP.,

	 	 	 a Delaware corporation,

	 	 	 managing member

			
	 	 	 By:
	 	 /s/ Jennifer Pappas


	 	 	 Its:
	 	 Vice President and Assistant Secretary

	
	TENANT:
	
	BIO VEST INTERNATIONAL, INC.,
	 a Delaware corporation

		
	 By:
	 	 /s/ James McNulty


	 Name:
	 	 James A. McNulty

	 Its:
	 	 CFO



  

 5 








 EXHIBIT A 
  

Description of Additional Premises 
  
 [Attached] 
  

 6 








 THIRD AMENDMENT TO LEASE 
  
 THIS THIRD AMENDMENT TO LEASE (“Amendment”) is made as of this 5th day of April, 2005, by and between ARE-377 PLANTATION STREET, LLC, a Delaware limited liability company (“Landlord”),
and BIOVEST INTERNATIONAL, INC., a Delaware corporation (“Tenant”). 
  
 RECITALS 
  
 A. Worcester Business Development Corporation, the predecessor-in-interest to Landlord, and Unisyn Technologies, Inc., the predecessor-in-interest to Tenant, entered into that certain Space Lease dated as of October 26, 1995, as
amended by that certain First Amendment to Lease dated August 7, 1996, and as amended by that certain Second Amendment to Lease dated January 25, 2005 (as amended, the “Lease”), pursuant to the terms of which Tenant is
leasing from Landlord approximately 17,295 rentable square feet in the building located at 377 Plantation Street, Worcester, Massachusetts. All capitalized terms not otherwise defined herein shall have the meanings given them in the Lease.

  
 B. The Stated Expiration Date of the Lese is February 28,
2006. Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the Lease in order to, among other things, extend the term of the Lease until February 28, 2010. 
  
 NOW, THEREFORE, in consideration of the covenants, conditions and agreements
contained herein, and of other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree as follows: 
  
 1. Term. The Stated Expiration Date of the Lease is hereby extended from February 28, 2006, until
February 28, 2010. Notwithstanding anything to the contrary contained in the Lease, Tenant shall have no further rights to extend the Lease Term. 
  
 2. Basic Rent. 
  
 (a) Commencing on March 1, 2006 (“Third Amendment Commencement Date”), Tenant shall pay annual Basic
Rent for the Premises in the amount of $23.75 per rentable square foot of the Premises per year on an absolute triple net basis. The annual Basic Rent shall continue to be payable in equal monthly installments in advance on the first day of each
calendar month. 
  
 (b) Annual Basic Rent shall
be increased on each annual anniversary of the Third Amendment Commencement Date during the Lease Term (each an “Adjustment Date”) by multiplying the annual Basic Rent payable immediately before such Adjustment Date by 3.5%
and adding the resulting amount to the Basic Rent payable immediately before such Adjustment Date. Basic Rent, as so adjusted, shall thereafter be due as provided herein. 
  
 (c) Effective from and after the date hereof, Exhibit E of the Lease is deleted in its entirety and
shall have no further or effect. 
  

 1 








 3. Tenant Improvements. Landlord shall make available to Tenant a tenant improvement
allowance of up to $138,360 (the “TI Allowance”) for the construction of improvements to the Premises desired by and to be performed by Tenant (subject to Landlord’s supervision) and which improvements shall be of a fixed and
permanent nature (the “New Tenant Improvements”). Tenant acknowledges and agrees that Landlord’s prior written consent shall be required with respect to the New Tenant Improvements including, without limitation, review and
approval of the plans for the same. Except for the TI Allowance, Tenant shall be solely responsible for all of the costs of the New Tenant Improvements. The New Tenant Improvements shall be treated as alterations and shall be undertaken pursuant to
Section 7.06 of the Lease. The New Tenant Improvements shall be designed and constructed by architects and contracts selected by Tenant and approved by Landlord. Landlord shall also have the right to review and approve all contracts
entered into by Tenant in connection with the New Tenant Improvement including, without limitation, the provisions in such contracts dealing with insurance, indemnity and lien waivers. Landlord shall not unreasonably delay its review and approval of
such contracts. Landlord shall fund the TI Allowance upon completion of the New Tenant Improvements and upon presentation to Landlord of a draw request containing unconditional lien waivers and such other documents as are customary for construction
projects in the Worcester area. Promptly following completion of the New Tenant Improvements and prior to funding by Landlord, Tenant shall provide to Landlord: (i) sworn statements setting forth the names of all contractors and subcontractors
who did the work on the New Tenant Improvements and final lien waivers from all such contractors and subcontractors; and (ii) a certificate of occupancy and “as built” plans for the New Tenant Improvements. Tenant acknowledges and
agrees that the construction of the New Tenant Improvements may adversely affect Tenant’s use and occupancy of the Premises and Tenant shall not be entitled to any rent abatement or offset in connection therewith. 
  
 4. Miscellaneous. 
  
 (a) This Amendment is the entire agreement between the
parties with respect to the subject matter hereof and supersedes all prior and contemporaneous oral and written agreements and discussions. This Amendment may be amended only by an agreement in writing, signed by the parties hereto. 
  
 (b) This Amendment is binding upon and shall inure to the
benefit of the parties hereto, their respective successors and assigns. 
  
 (c) Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person (collectively, “Broker”) in connection with this Amendment and that no Broker brought
about the transaction evidenced by this Amendment. Landlord and Tenant each hereby agree to indemnify and hold the other harmless from and against any claims by any Broker claiming a commission or other form of compensation by virtue of having dealt
with Tenant or Landlord, as applicable, with regard to this Amendment. 
  
 (d) This Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken together shall constitute one and the same instrument. The signature page of any
counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to 

  

 2 








 
any other counterpart identical thereto except having additional signature pages executed by other parties to this Amendment attached thereto. 
  
 (e) Except as amended and/or modified by this Amendment, the
Lease is hereby ratified and confirmed and all other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this Amendment. Tenant acknowledges that Landlord is not currently in default of any obligation under the
Lease. Except as expressly provided herein, the Lease remains unmodified and in full force and effect. Any breach by Tenant of this Amendment shall constitute a breach and default by Tenant under the Lease. In the event of any conflict between the
provisions of this Amendment and the provisions of the Lease, the provisions of this Amendment shall prevail. Whether or not specifically amended by this Amendment, all of the terms and provisions of the Lease are hereby amended to the extent
necessary to give effect to the purpose and intent of this Amendment. 
  
 [Signatures on the next page] 
  

 3 








 IN WITNESS WHEREOF, Landlord and Tenant have each caused this Amendment to be duly executed, sealed and
delivered, by its duly authorized attorney in fact, as of the day and year first above written. 
  

					
	 LANDLORD:
  
 ARE-377 PLANTATION STREET, LLC,
 a Delaware limited liability
company

		
	By:	 	 ARE-GP/IV HOLDINGS QRS CORP.,
 a
Dela
 ware corporation,
 managing member

			
	 	 	By:	 	/s/ Jennifer Pappas
	 	 	Its:	 	V.P. & Assistant Secretary
	
	 TENANT:
  
 BIOVEST INTERNATIONAL, INC.,
 a Delaware
corporation

		
	By:	 	/s/ James A. McNulty
	Name:	 	James A. McNulty
	Its:	 	CFO/Secretary