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                                                                    EX: No. 10.1

                                  BIOGEN, INC.
                        1982 INCENTIVE STOCK OPTION PLAN
                       (AS AMENDED THROUGH JUNE 15, 2000)

I.   DEFINITIONS AND PURPOSE

     A.   Definitions: References in this document to the "Company" are to
Biogen, Inc., a Massachusetts corporation; reference to the "Plan" are to the
Biogen, Inc. 1982 Incentive Stock Option Plan; references to the "Code" are to
the United States Internal Revenue Code of 1986, as amended. Unless otherwise
specified or unless the context otherwise requires, the following terms, as used
in the Plan, have the following meanings:

     1. "Affiliate" means a corporation which, for purposes of Section 422 of
the Code, is a parent or subsidiary of the Company, direct or indirect.

     2. "Disability" means permanent and total disability as defined in Section
105(d)(4) of the Code.

     3. "Key Employee" means an employee of the Company or of an Affiliate
(including, without limitation, an employee who is also serving as an officer of
the Company or of an Affiliate), designated by the Committee to be eligible to
be granted one or more Options under the Plan.

     4. "Option" means a right or option granted under the Plan.

     5. "Participant" means a Key Employee to whom one or more Options are
granted under the Plan. As used herein, "Participant" shall include
"Participant's Survivors" where the context requires.

     6. "Participant's Survivors" means a deceased Participant's legal
representatives and/or any person or persons who acquired the Participant's
rights to an Option by will or by the laws of descent and distribution.

     7. "Shares" mean those shares of the Common Stock, $.01 par value, of the
Company as to which Options have been or may be granted under the Plan.

     B.   Purposes Of The Plan: The Plan is intended to encourage ownership of
the Shares of the Company by Key Employees in order to attract such Key
Employees, to induce such Key Employees to remain in the employ of the Company
or of an Affiliate and to provide additional incentive for such Key Employees to
promote the success of the Company or its Affiliates. It is further intended
that Options issued pursuant to the Plan shall be eligible to constitute
"incentive stock options" within the meaning of Section 422 of the Code.


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II.  SHARES SUBJECT TO THE PLAN

     The aggregate number of Shares as to which Options may be granted from time
to time shall be 44,208,000; provided, however that such aggregate number shall
be reduced by the number of shares which have been sold under, or may be sold
pursuant to options granted from time to time under the Company's 1985
Non-Qualified Stock Option Plan (the "1985 Plan"), to the same extent as if such
sales had been made or options granted pursuant to this Plan.

     If any option granted under this Plan or the 1985 Plan ceases to be
"outstanding", in whole or in part, other than by reason of the exercise of such
option, the shares which were subject to such option shall be available for the
granting of other Options. Any option shall be treated as "outstanding" until
such option is exercised in full, terminates under the provisions of this Plan
or the 1985 Plan, as the case may be, or expires by reason of lapse of time.

     The aggregate number of Shares as to which Options may be granted shall be
subject to change only by means of an amendment of the Plan duly adopted by the
Company and approved by the Shareholders of the Company within one year before
or after the date of the adoption of any such amendment, subject to the
provisions of Article VII.

III. ADMINISTRATION OF THE PLAN

     The Plan shall be administered by the Stock and Option Plan Administration
Committee of the Company (the "Committee"). The membership of the Committee
shall be determined and shall be subject to change without cause and without
notice from time to time, by the Company.

     The Committee is authorized to interpret the provisions of the Plan or of
any Option and to make all rules and determinations necessary or advisable for
the administration of the Plan. It may from time to time determine which
employees of the Company or of any Affiliate shall be designated as Key
Employees and which of the Key Employees shall be granted Options and, subject
to the other provisions of the Plan, the number of Shares for which an Option or
Options shall be granted. Subject to the provisions of the Plan, Options may be
granted upon such terms and conditions as the Committee may prescribe; provided,
however, that such terms and conditions shall be prescribed in the context of
preserving, to the extent reasonably possible, the United States tax status of
the Options as incentive stock options.

     This Plan is intended to comply in all respects with Rule 16b-3 or its
successors promulgated under the Securities Exchange Act of 1934 ("1934 Act")
with respect to participants who are subject to Section 16 of the 1934 Act, and
any provision in this Plan with respect to such persons contrary to Rule 16b-3
shall be deemed null and void to the extent permissible by law and deemed
appropriate by the Committee.


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IV.  ELIGIBILITY FOR PARTICIPATION

     Each Participant must be a Key Employee of the Company or of an Affiliate
at the time an Option is granted.

     The Committee may grant to one or more Key Employees one or more Options,
and shall designate the number of Shares to be optioned under each Option so
granted; provided, however, that no Options shall be granted after December 31,
2002, and provided further, that the fair market value (determined as of the
date the Options are granted) of the Shares as to which incentive stock options
granted on or after January 1, 1987 by the Company or its Affiliates to any
individual employee under the Plan and/or under any other incentive stock option
plans are exercisable for the first time in any one calendar year shall not
exceed $100,000.

     Notwithstanding any of the foregoing provisions, the Committee may
authorize the grant of an Option to a person not then in the employ of the
Company or of an Affiliate, conditioned upon such person becoming eligible to be
a Participant at or prior to the execution of the Option agreement evidencing
such Option.

     In no event shall any employee be granted in any calendar year options to
purchase or receive more than 2,400,000 shares of the Company's Common Stock
pursuant to this Plan.

V.   TERMS AND CONDITIONS

     Each Option shall be set forth in writing in an Option agreement, duly
executed on behalf of the Company and by the Participant to whom such Option is
granted. No Option shall be deemed to have been granted and no purported grant
of any Option shall be effective, until such Option shall have been approved by
the Committee. The Committee may provide that Options be granted subject to such
conditions as the Committee may deem appropriate, including without limitation,
subsequent approval by the shareholders of the Company of this Plan or any
amendments thereto. Each such Option agreement shall be subject to at least the
following terms and conditions:

     A.   Option Price: If, including for this purpose the Shares which are the
subject of Options previously granted and outstanding or proposed to be granted
hereunder, the optionee owns 10% or less of the total combined voting power of
all classes of share capital of the Company, the Option price (per share) of the
Shares covered by each Option granted hereunder shall be not less than the fair
market value (per share) of the Shares on the date of the grant of the Option;
provided, however, that in no event shall the Option price be less than the par
value per share of Common Stock. In all other cases, the Option price shall be
not less than 110% of the said fair market value. For purposes hereof, the fair
market value shall be the average between the high and low sale prices, as
reported in the National Association of Securities Dealers Automated Quotation
System ("NASDAQ") for the date of the grant of the Option or, if none, for the
most recent trading date thirty (30) days or less prior to the date of the grant
of the Option


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on which the Common Stock was traded. If the fair market value cannot be
determined under the preceding sentence, it shall be determined in good faith by
the Committee.

     B.   Number of Shares: Each Option shall state the number of Shares to
which it pertains.

     C.   Term of Option: Each Option shall terminate at such date as the
Committee, at the time it authorizes the grant of the Option, shall determine,
and shall be subject to earlier termination as herein provided, except that if
the option price is required under Paragraph A of this Article V to be at least
110% fair market value, each such Option shall terminate not more than five (5)
years from the date of the grant hereof; and provided that in no case may the
term of any Option exceed ten (10) years.

     D.   Date of Exercise: The Committee may prescribe the date or dates on
which the Option becomes exercisable, and may provide that the Option rights
accrue or become exercisable in installments over a period of months or years,
or upon the attainment of stated goals. The Committee may stipulate that any
Option which becomes exercisable shall be subject to cancellation or that Shares
purchased upon the exercise of such Option shall be subject to repurchase rights
in favor of the Company. In such event, the Committee shall determine the date
or dates, or event or events, upon which such cancellation or repurchase rights
shall become effective or shall lapse, as the case maybe.

     E.   Medium of Payment: The option price shall be payable upon the exercise
of the Option. It shall be payable in cash, or, if permitted by the Committee
and by Section 422 of the Code, in shares or other consideration.

     F.   Prior Options: By its terms, each Option granted prior to January 1,
1987 under the Plan to a Participant, shall not be exercisable while there
is"outstanding" any other incentive stock option (as defined in the predecessor
to Section 422 of the Code), which was granted before the grant of such Option,
to such Participant to purchase Shares in the Company or in an Affiliate or in a
predecessor of the Company or of an Affiliate.

     G.   Termination of Employment: A Participant who ceases (for any reason
other than death or disability or termination by the Participant's employer for
cause) to be an employee of the Company or of an Affiliate, may exercise any
Option granted to such Participant, to the extent that the right to purchase
Shares thereunder has accrued on the date of such termination of employment, but
only within three (3) months, or such shorter period as may be determined by the
Committee, after such date, or, if earlier, within the originally prescribed
term of the Option. A Participant's employment shall not be deemed terminated by
reason of a transfer to another employer which is the Company or an Affiliate.

     A Participant whose employment is terminated by the Participant's employer
for cause shall forthwith upon such termination cease to have any right to
exercise any Option. For purposes of this paragraph, "cause" shall be deemed to
include dishonesty with respect to the


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employer, insubordination, substantial malfeasance or non-feasance of duty,
unauthorized disclosure of confidential information, and conduct substantially
prejudicial to the business of the Company or any Affiliate. The determination
of the Committee as to the existence of cause shall be conclusive on the
Participant and Company.


     A Participant to whom an Option has been granted under the Plan who is
absent from work with the Company or with an Affiliate because of temporary
disability, or who is on leave of absence for any purpose permitted by any
authoritative interpretation of Section 422, shall not, during the period of any
such absence, be deemed, by virtue of such absence alone, to have terminated his
employment with the Company or with an Affiliate, except as the Committee may
otherwise expressly provide.

     H.   Disability: If a Participant ceases to be an employee of the Company
or of an Affiliate by reason of Disability, any Option held by him or her on the
date of Disability shall be exercisable as to all or any part of the Shares
subject to the Option, all of which shares shall be fully vested as of the date
of such Disability. A Disabled Participant may exercise such Option only within
a period of one (1) year after the date as of which the Committee determines
that he or she became Disabled, or, if earlier, within the originally prescribed
term of the Option.

     I.   Death: If a Participant dies while the Participant is an employee of
the Company or of an Affiliate, any Option held by him or her at the date of
death shall be exercisable as to all or any part of the Shares subject to the
Option, all of which shares shall be fully vested as of the date of the
Participant's death. A deceased Participant's Survivors may exercise such Option
only within a period of one (1) year after the date of death, or, if earlier,
within the originally prescribed term of the Option.

     J.   Exercise of Option and Issue of Shares: Options shall be exercised by
giving written notice to the Company, addressed to the Company at the address
specified in the Option agreement, with which the Participant shall tender the
Option price. Such written notice shall be signed by the person exercising the
Option, shall state the number of Shares with respect to which the Option is
being exercised, and shall contain any warranty required by Article VI. The
issuance of the Shares may be delayed by the Company if any law or regulation
requires the Company to take any action with respect to the shares prior to the
issuance thereof. Without limiting the generality of the foregoing, nothing
contained herein shall be deemed to require the Company to issue any Shares if
prohibited by law or applicable regulation.

     The Shares shall, upon delivery, be evidenced by an appropriate certificate
or certificates in respect of paid-up, non-assessable Shares.

     K.   Rights as a Shareholder: No Participant to whom an Option has been
granted shall have rights as a shareholder with respect to any Shares covered by
such Option except as to such Shares as have been registered in the Company's
share register in the name of such Participant upon the due exercise of the
Option.


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     L.   Assignability and Transferability of Options: By its terms, an Option
granted to a Participant shall not be transferable by the Participant otherwise
than by will or by the laws of descent and distribution and shall be
exercisable, during the Participant's lifetime, only by such Participant. Such
Option shall not be assigned, pledged, or hypothecated in any way (whether by
operation of law or otherwise) and shall not be subject to execution,
attachment, or similar process. Any attempted transfer, assignment, pledge,
hypothecation, or other disposition of any Option or of any rights granted
thereunder contrary to the provisions of this Paragraph L, or the levy of any
attachment or similar process upon an Option or such rights, shall be null and
void.

     M.   Tax Withholding: In the event that any federal, state, or local income
taxes, employment taxes, Federal Insurance Contributions Act ("F.I.C.A.")
withholdings or other amounts are required by applicable law or governmental
regulation to be withheld from the Option holder's salary in connection with the
exercise of an Option, the Option holder shall advance in cash to the Company,
or to any Affiliate of the Company which employs or employed the Option holder,
the amount of such withholdings unless a different withholding arrangement,
including the use of shares of the Company's Common Stock, is authorized by the
Committee (and permitted by law), provided, however, that with respect to
persons subject to Section 16 of the 1934 Act, any such withholding arrangement
shall be in compliance with any applicable provisions of Rule 16b-3 promulgated
under Section 16 of the 1934 Act. For purposes hereof, the fair market value of
the shares withheld for purposes of payroll withholding shall be determined in
the manner provided in Section V.A. above, as of the most recent practicable
date prior to the date of exercise. If the fair market value of the shares
withheld is less than the amount of payroll withholdings required, the Option
holder may be required to advance the difference in cash to the Company or the
Affiliate employer.

     N.   Reload Options: Concurrently with the award of Options under the Plan,
the Committee may authorize reload options ("Reload Options") to purchase for
cash or shares a number of shares of Common Stock. The number of Reload Options
shall equal (i) the number of shares of Common Stock used to exercise the
underlying Options and (ii) to the extent authorized by the Committee, the
number of shares of Common Stock used to satisfy any tax withholding requirement
incident to the exercise of the underlying Options. The grant of a Reload Option
will become effective upon the exercise of underlying Options or Reload Options
through the use of shares of Common Stock held by the optionee for at least 6
months. Reload Options must be evidenced in Option agreements. The Option price
per share of Common Stock deliverable upon the exercise of a Reload Option shall
be determined in accordance with Paragraph V.A. hereof on the date the grant of
the Reload Option becomes effective. The term of each Reload Option shall be
equal to the remaining option term of the underlying Option. No additional
Reload Options shall be granted to Option holders when Options and/or Reload
Options are exercised pursuant to the terms of this Plan following termination
of the Option holder's employment or on account of death or total and permanent
disability. All other provisions of this Plan with respect to Options shall
apply equally to Reload Options.


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     O.   Other provisions: The Option agreements authorized under the Plan
shall be subject to such other terms and conditions, including, without
limitation, restrictions upon the exercise of the Option, as the Committee shall
deem advisable. Any such Option agreement shall contain such limitations and
restrictions upon the exercise of the Option as shall be necessary in order that
such Option can be an "incentive stock option" within the meaning of the Section
442 of the Code.

VI.  PURCHASE FOR INVESTMENT

     If, and to the extent that, the issuance of Shares pursuant to the exercise
of Options is deemed by the Company to be subject to the United States
Securities Act of 1933, as now in force or hereafter amended, ("1993 Act"), or
to the securities laws of any other jurisdiction, the Company shall be under no
obligation to issue the Shares covered by such exercise unless the person or
persons who exercises or who exercise such Option shall make such warranty as
may be required by any applicable securities law of any applicable jurisdiction
and shall, in the case of the applicability of the 1933 Act, in the absence of
an effective registration under such Act with respect to such Shares, warrant to
the Company, at the time of such exercise, that such person is or that they are
acquiring the Shares to be issued to such person or to them, pursuant to such
exercise of the Option, for investment and not with a view to, or for sale in
connection with, the distribution of any such Shares; and in such events the
person or persons acquiring such Shares shall be bound by the provisions of a
legend endorsed upon any share certificates expressing the requirements of any
applicable non-United States securities law, or, in cases deemed governed by the
1933 Act substantially the following legend, which shall be endorsed upon the
certificate or certificates evidencing the Shares issued by the Company pursuant
to such exercise:

          "The shares have not been registered under the securities laws of any
          country including the United States Securities Act of 1933, as
          amended, and the Company may refuse to permit the sale or transfer of
          all or any of the shares until (1) the Company has received an opinion
          of Counsel satisfactory to the Company that any such transfer is
          exempt from registration under all applicable securities laws or (2)
          in the case of sales or transfer to which the United States Securities
          Act of 1933 is applicable, unless a registration statement with
          respect to such shares shall be effective under such Act, as amended."

     Without limiting the generality of the foregoing, the Company may delay
issuance of the Shares until completion of any action or obtaining of any
consent which the Company deems necessary under any applicable law (including,
without limitation, state securities or "blue sky" laws).

VII. ADJUSTMENTS UPON CHANGES IN CAPITALIZATION

     In the event that the outstanding Common Stock, $.01 par value, of the
Company is changed into or exchanged for a different number or kind of shares or
other securities of the


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Company or of another corporation by reason of any reorganization, merger,
consolidation, recapitalization, reclassification, change in par value, stock
split-up, combination of shares or dividend payable in capital stock, or the
like, appropriate adjustment shall be made in the number and kind of Shares for
the purchase of which Options may be granted under the Plan, and, in addition,
appropriate adjustment shall be made in the number and kind of Shares and in the
Option price per share subject to outstanding Options so that each Option holder
shall be in a position equivalent to the position the Option holder would have
been in had the Option holder exercised the Options immediately prior to the
applicable event. No such adjustment shall be made which shall, within the
meaning of Section 424 of the Code, constitute such a modification, extension or
renewal of any Option as to cause it to be considered as the grant of a new
Option.

VIII. DISSOLUTION OR LIQUIDATION OF THE COMPANY

     Upon the dissolution or liquidation of the company other than in connection
with a transaction to which the preceding Article VII is applicable, all Options
granted hereunder shall terminate and become null and void; provided, however,
that if the rights of a Participant or the Participant's Survivors hereunder
have not otherwise terminated and expired, the Participant or the Participant's
Survivors shall have the right immediately prior to such dissolution or
liquidation to exercise any Option granted hereunder to the extent that the
right to purchase Shares thereunder has accrued as of the date of exercise
immediately prior to such dissolution or liquidation.

IX.  TERMINATION OF THE PLAN

     The Plan shall terminate on December 31, 2002. The Plan may be terminated
at an earlier date by vote of the Shareholders; provided, however, that
expiration or any such earlier termination shall not affect any Option granted
or Option agreements executed prior to expiration or the effective date of such
termination.

X.   AMENDMENT OF THE PLAN

     The Plan may be amended by action of the Committee or the Board of
Directors of the Company; provided, however, that if the scope of any amendment
is such as to require shareholder approval in order to preserve incentive stock
option treatment, then such amendments shall also require approval, within one
(1) year before or after the adoption thereof, by the shareholders, and provided
further that if the scope of any amendment is such as to require shareholder
approval in order to comply with Rule 16b-3 under the 1934 Act, then such
amendment shall also require approval by the shareholders. Any amendment shall
not affect any Options theretofore granted and any Option agreements theretofore
executed by the Company and a Participant, unless such amendment shall expressly
so provide. No amendment shall adversely affect any Participant with respect to
an outstanding Option without the written consent of such Participant. With the
consent of the Option holder affected, the Committee may amend any outstanding
Option agreement in a manner not inconsistent with the plan, including, without
limitation, to accelerate the date of exercise of any installment of any Option.


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XI.  EMPLOYMENT RELATIONSHIP

     Nothing herein contained shall be deemed to prevent the Company or an
Affiliate from terminating the employment of a Participant, nor to prevent a
Participant from terminating the Participant's employment with the Company or an
Affiliate.

XII. EFFECTIVE DATE

     This Plan first became effective as of January 8, 1982, subject to the
approval, within one (1) year after such adoption, of the shareholders of the
Company.


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