SAT Report

PMN Number: P-15-0025

SAT Date: 10/21/2014

Print Date: 2/3/2015

Related cases: CBI: Yes

Health related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 3 Health: ; Eco: chronic concerns only

 Persistence Bioaccum Toxicity Comments

1 21

Exposure Based Review:

Health: No

Ecotox: Yes

Routes of exposure: Health: Dermal Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: IRR-S,E,MM,L; SENS-S (UNCERT); AQUATOX

Summary of Assessment:

 Fate:

Fate Summary: P-15-0025

FATE: 

Liquid with MP < 25 C (E)

log Kow = 7.49 (E) 

S = 0.005 mg/L at 25 C (E)

VP = 2.8E-4 torr at 25 C (E)

BP = 337 C (E)

H = 1.17E-2 (E)

log Koc = 4.65 (E)

log Fish BCF = 3.29 (E)
log Fish BAF = 4.25 (E) 

POTW removal (%) = 90 via sorption and possible biodeg; Analog: OECD 301D(Closed Btl): 

85%/28d.

Time for complete ultimate aerobic biodeg = wk-mo

Sorption to soils/sediments = strong

Volatilization half-life from a standard river = 2 hrs

Volatilization half-life from a standard lake = 6 da

Atmospheric Oxidation Half-life = 6 hr via OH radical

PBT Potential: P1B2

*CEB FATE: Migration to ground water = slow

 Health:

 Health Summary: Absorption is poor all routes (pchem). Concern for 

irritation to all tissues and uncertain concern for dermal sensitization based on test data for 

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 *

daphnid 48-h LC50 * 0.030

green algal 96-h EC50 *

fish _ chronic value 0.001

daphnid _ chronic 

value

0.001 0.003

algal _ chronic 

value

0.014

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on ; 

liquid with mp unknown (P); log Kow = 7.34 (EPI); S = 

0.005 mg/L at 25 C (P); pH7; effective concentrations based on 100% active ingredients and 

mean measured concentrations; hardness < 150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Ecotoxicity Test Data Results for P-15-0025: 

An acute daphnid toxicity study was conducted on an analog of the PMN (P-15-0025). The 

analog was ; . EPA classified 

the PMN and the analog as a . Based on structural depictions, the difference between the 

analog and the PMN is the presence of a double bond that is not nearby the group (i.e., not 

in the alpha or beta position) and minimal branching, which makes it a good analog. The PMN 

was predicted to have a water solubility of 0.005 mg/L and a Log Kow of 7.5. 
Daphnid Toxicity Summary:

 conducted a 48-hour acute immobilization test in Daphnia magna 

with an analog test substance (101.1% (w/w) active content ) under semi-static conditions 

with 24-hour renewal. This study was reported to follow OECD test guideline No. 202 (2004). 

Following a range-finding test, four replicates of five D. magna were exposed to a dilution water 

control (filtered natural river water) or the test substance prepared as a water soluble fraction 

(WSF) at nominal loading levels of 0.032, 0.1, 0.32, 1.0, 3.2 or 10.0 mg/L. Corresponding 

geometric mean initially measured concentrations were 0.0160, 0.0569, 0.155, 0.542, 1.90 and 

5.91 mg/L (48 – 59% of nominal), as determined by GC-MS analysis (LOQ = 2.0 μg/L, 

enrichment factor taken into account). EPA prefers analytically confirmed test concentrations at 

study termination for all exposures, but the submitter demonstrated that loss was minimal during 

the renewal period. The nominal 10 mg/L WSF was prepared by shaking with 20 rpm for 24 

hours at room temperature, followed by a separation phase of at least 24 hours. Afterwards, the 

WSF was taken from the homogenous liquid phase. No filtration was applied to prepare the 

WSF. The 10 mg/L WSF was diluted to prepare the desired nominal loading levels. The 

concentrations of test substance were analyzed at all concentration levels from freshly prepared 

media and at two concentration levels (nominal 0.1 and 1.0 mg/L) from old media. Recoveries 

of fresh media ranged from 44 – 62% of nominal values; recoveries of old media ranged from 34 

– 66% of nominal values. Over the course of testing, temperature was maintained at 18 – 22°C, 

±1°C, pH ranged from 7.53 – 7.87 and dissolved oxygen ranged from 8.24 – 9.63 mg/L. 

Dilution water hardness was 154 mg CaCO-3/L; was 3.9 mg/L. A loading rate of 250 

daphnids/L was calculated, which is considered high and may result in crowding. The % 

immobilization at geometric mean initially measured concentrations of 0 (control), 0.0160, 

0.0569, 0.155, 0.542, 1.90 and 5.91 mg/L was 0, 10, 90, 100, 100, 100 and 100%, respectively at 

48 hours. Based on geometric mean initially measured concentrations, the 48-hour EC50 was 

0.0302 mg/L. Each test concentration is supposed to be prepared independently for water soluble 

fractions; however, analytic monitoring confirmed test concentrations.

48-hour EC50 = 0.0302 mg/L 

Conclusion: The acute daphnid study was acceptable. No fish and algae data were provided. An 

acute of 0.006 mg/L (6 ppb) was concluded from the experimental daphnid 48-hour EC50 

of 0.0302 mg/L with application of an assessment factor of 5 to account for species sensitivity 

distributions. A chronic of 0.001 mg/L (1 ppb) was concluded based on the predicted fish 

ChV of 0.001 mg/L and application of an assessment factor of 10 to account for species 

sensitivity distributions.

Acute : 6 ppb

Chronic : 1 ppb

Reviewer: K.Moran

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

1
SARs

SAR Class

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: L Keifer 564-8916