Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

Office of Chemical Safety and Pollution Prevention

MEMORANDUM

Date: 15-January-2015

Subject: Difenoconazole. Acute and Chronic Aggregate Dietary Exposure and Risk 

Assessments for the Petition for Use of Difenoconazole on Rapeseed Crop Subgroup 

20A and Imported Dragonfruit.

PC Code: 128847 DP Barcode: 412812 & 422170

Decision No.: 473631 & 493233 Registration No.: 100-1262

Petition Nos.: 2F8134 & 4E8296 Regulatory Action: Amended Section 3

Assessment Type: Single Chemical, Dietary Registration Case No.: NA

TXR No.: None CAS No.: 119446-68-3

MRID No.: None 40 CFR: 180.475

Reviewer: Thurston G. Morton, Chemist

Risk Assessment Branch IV/Health Effects Division (RABIV/HED; 7509P)

Through: Tom Bloem, Chemist

William Cutchin, Chemist

Dietary Exposure Science Advisory Council (DESAC)

And

Elissa Reaves PhD., Branch Chief

RABIV/HED (7509P)

To: Thurston G. Morton, Risk Assessor

RABIV/HED (7509P)

And

Rosemary Kearns/Tony Kish (RM 22)

 Fungicide Branch

Registration Division (7505P)

Executive Summary
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Difenoconazole acute and chronic dietary exposure and risk assessments were conducted using 

the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 

(DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption data from the 

U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey, 

What We Eat in America, (NHANES/WWEIA). This dietary survey was conducted from 2003 

to 2008. The analyses were performed to support the Section 3 registration on Rapeseed Crop 

Subgroup 20A of the fungicide difenoconazole [1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-

methyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole] and the use of difenoconazole on imported 

dragonfruit. 

This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 

2012.1. 

The unrefined acute analysis assumed tolerance-level residues, 100% crop treated (CT), and the 

available empirical or DEEM (ver. 7.81) default processing factors. The somewhat refined 

chronic analysis assumed tolerance-level residues for some commodities, average field trial 

residues for the majority of commodities, the available empirical or DEEM (ver. 7.81) default 

processing factors, and 100 % CT. The EDWC of 20.0 μg/L (ppb) was used for the acute dietary

exposure analysis and an estimated drinking water concentrations (EDWC) of 13.6 μg/L (ppb) 

was used for the chronic dietary exposure analysis.

The resulting acute food plus water exposure estimates were less than HED’s level of concern (-

<100% of the acute population-adjusted dose (aPAD)) at the 95th percentile of the exposure 

distribution for the general U.S. population (12 % aPAD) and all population sub-groups; the 

most highly exposed population subgroup was children1-2 years old with 27 % aPAD. The 

resulting chronic food plus water exposure estimates were less than HED’s level of concern (-

<100% of the chronic population-adjusted dose (cPAD)) for the general U.S. population (30 % 

cPAD) and all population sub-groups; the most highly exposed population subgroup was 

children 1 - 2 years old with 75 % cPAD. No cancer analysis was performed since it was 

determined the chronic dietary exposure assessment is protective of cancer effects.

The dietary exposure analyses for the triazole metabolites were updated (D414951, T. 

Morton, 24 Oct. 2013).

I. Introduction
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Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the PAD. The PAD is equivalent to the point of departure (POD, 

NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton (30-

May-2012; DP#397664).

II. Residue Information

Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock: 

Residues of concern were determined based on recommendations from the HED Residues of 

Concern Knowledgebase Sub-committee (ROCKS) (D391350, 9/19/11). The residue of concern 

for plant commodities for tolerance expression and risk assessment purposes is difenoconazole 

per se. The HED ROCKS has determined that the parent compound and the CGA-205375 

metabolite are the residues of concern in livestock commodities for both the tolerance expression 

and the risk assessment. In addition, metabolite OH-CGA-169374, which comprised 15% of the 

TRR in goat milk from the phenyl-labeled study, should be considered as a residue of concern 

for the dietary risk assessment. Based on available goat metabolism data, total residues of 

concern in milk for dietary risk assessments (parent, CGA-205375, and OH-CGA-169374), 

should be calculated by multiplying the tolerance in milk by a factor of 1.5x. Table 1 

summarizes tolerance expression and the residues of concern in plant and livestock commodities.

Table 1. Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants Primary and Rotational crops Parent Only Parent Only

Livestock Ruminant and Poultry Parent and CGA 205375 Parent and CGA 205375

Milk Parent, CGA 205375 and 

OH-CGA-169374

Parent and CGA 205375

Drinking Water Parent Only NA

Note: The triazole-containing metabolites 1,2,4-T, TA, and TAA should be included in the residues of concern for risk 

assessment purposes only for plant and livestock commodities. Since these metabolites are common to the entire class of 

traizole-derivative fungicides and because of differential toxicity between metabolites and the various parent compounds, risks 

associated with exposure to 1,2,4-T and to TA/TAA are addressed separately.

Recommended Tolerances: Based on the residue chemistry data submitted with the previous

petitions, HED recommended for establishment of the new food tolerances (DP# 412810, B. 
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Cropp-Kohlligian, 22-August-2013). The recommended, established, and revised tolerances are 

listed in Table 2 below.

Table 2. Tolerance Summary for Difenoconazole (non feed items).

Commodity Existing/Established 

Tolerances (ppm)

New Tolerances (ppm)

Rapeseed crop subgroup 20A ----- 0.10

Almond, nutmeat 0.03 ------

Brassica subgroup 5A 1.9 ------

Brassica subgroup 5B 35 ------

Citrus oil 25 ------

Fruit, citrus, group 10 0.6 ------

Grape 4.0 ------

Grape, raisin 6.0 ------

Nut, tree, group 14 0.03 ------

Onion, bulb, subgroup 3—07A 0.20 ------

Onion, green, subgroup 3—07B 6.0 ------

Pistachios 0.03 ------

Vegetable, cucurbit, group 9 0.7 ------

Fruit, Pome, group 11 1.0 ------

Vegetable, Fruiting, Group 8 0.60 ------

Vegetable, Tuberous and Corm, 

subgroup 1C

4.0 4.0

Beet, sugar 0.30 ------

Papaya 0.30 ------

Banana 0.2 ------

Barley, grain 0.1 ------

Canola, seed 0.01 ------

Cattle fat 0.10 ------

Cattle, meat 0.05 ------

Cattle, meat byproducts 0.10 ------

Cattle, liver 0.40 ------

Corn, sweet, kernel plus cob 

with husks removed

0.01 ------

Cotton, undelinted seed 0.05 ------

Egg 0.02 ------

Goat, fat 0.10 ------

Goat, meat 0.05 ------

Goat, meat byproducts (except 

liver)

0.10 ------

Goat, liver 0.40 ------

Hog, fat 0.10 ------

Hog, meat 0.05 ------

Hog, meat byproducts (except 

liver)

0.1 ------

Hog, liver 0.40 ------
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Table 2. Tolerance Summary for Difenoconazole (non feed items).

Commodity Existing/Established 

Tolerances (ppm)

New Tolerances (ppm)

Horse, fat 0.10 ------

Horse, meat 0.05 ------

Horse, meat byproducts (except 

liver)

0.10 ------

Horse, liver 0.40 ------

Milk 0.01 ------

Rye, grain 0.01 ------

Sheep, fat 0.10 ------

Sheep, meat 0.05 ------

Sheep, meat byproducts (except 

liver)

0.10 ------

Sheep, liver 0.40 ------

Wheat, grain 0.1 ------

Wax apple 0.07 ------

Mango 0.07 ------

Carrot 0.50 ------

Chickpea 0.08 ------

Soybean, seed 0.15 ------

Fruit, stone, group 12 2.5 ------

Strawberry 2.5 ------

Turnip greens 35 ------

Oat, grain 0.01 ------

Wax Jambu 1.5

Dragonfruit 1.5 (translated from wax jambu)

The dietary exposure analyses for the triazole metabolites (D414951, T. Morton, 24 Oct. 

2013) was updated.

Food Residues and processing factors used in the Acute and Chronic Analysis: The acute 

analysis assumed tolerance-level residues and 100% CT for all the registered and proposed 

crops. Tolerance-level residues were also assumed for all livestock tissues in this assessment. 

The chronic analysis assumed tolerance-level residues for some commodities, average field trial 

residues for the majority of commodities, and 100 % CT. Those commodities where field trial 

data were used are summarized below. HED SOP 2000.1 Guidance for Translation of Field 

Trial Data from Representative Commodities in the Crop Group Regulation to Other 

Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to other 

commodities in the crop group. Experimental processing factors were used for apple juice 

(0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), 

raisin (3.5x chronic only since the raisin tolerance was used in acute), sugar beet molasses (0.6x), 

tomato paste (1.6x), and tomato puree (0.5x); DEEM (ver. 7.81) default processing factors 

were assumed for other processed commodities. 

Almond: Field trial residues were used from MRID 47586101. 
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Apple: Field trial residues were used from MRID 46950233.

Broccoli: Field trial residues were used from MRID 47586102. Residues from 1-7 day PHI were 

used since registered labels allow from 1-7 day PHIs.

Cabbage: Field trial residues were used from 47586102. Residues from 1-7 day PHI were used 

since registered labels allow from 1-7 day PHIs. To refine the dietary exposure data from only

cabbage samples without wrapper leaves were used.

Cantaloupe: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI 

were used since registered labels allow from 0-1 day PHI.

Carrot: Field trial residues were used from MRID 47929804.

Chickpea: Field trial residues were used from MRID 47929805.

Cucumber: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI 

were used since registered labels allow from 0-1 day PHI.

Grape: Field trial residues were used from MRID 47586105.

Grapefruit: Field trial residues were used from MRID 47586104.

Lemon: Field trial residues were used from MRID 47586104.

Lime: Field trial residues were used from MRID 47586104.

Mustard Greens: Field trial residues were used from MRIDs 47417704, 47417707, and 

47586102. Residues from 1-7 day PHI were used since registered labels allow from 1-7 day

PHIs.

Orange: Field trial residues were used from MRID 47586104.

Pear: Field trial residues were used from MRID 46950233.

Pecan: Field trial residues were used from MRID 47586106.

Peppers: Field trial residues were used from MRID 46950234.

Potato: Field trial residues were used from MRID 47929804.

Soybean: Field trial residues were used from MRID 47929801.

Stone Fruit: Field trial residues were used from MRID 47929803.

Strawberry: Field trial residues were used from MRID 47929802.

Sugar Beet: Field trial residues were used from MRID 46950236.
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Summer Squash: Field trial residues were used from MRID 47586103. Residues from 0-1 day

PHI were used since registered labels allow from 0-1 day PHIs.

Tomato: Field trial residues were used from MRIDs 46950234, 47417705, and 47417708.

III. Percent Crop Treated Information

The acute and chronic dietary exposure analyses assumed 100% crop treated (CT).

IV. Drinking Water Data

The drinking water estimates used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED; Memo, F. Khan, 14-August-2013; D412614). 

For surface water, the EDWCs for canola/ oilseed subgroup 20A did not exceed the peak (acute) 

concentration of 17.4 μg/L, annual mean (non-cancer chronic) concentration of 11.8 μg/L and 

the 30 year annual average concentration (cancer chronic) of 8.6 μg/L for use on grape reported 

in the previous drinking water assessment (US EPA, 2012b; DP 398836 ). Therefore, the 

EDWCs for surface water for canola/ oilseed subgroup 20A (Table 1) did not supersede the 

previously recommended drinking water concentrations. However, the previously recommended 

EDWCs were based on 0.87 PCA (Percent Cropped Area) factor. Recently, EFED implemented 

a revised guidance for PCA (USEPA 2012a). Since difenoconazole can be used in both nonagricultural (turf) and various agricultural crops, a PCA of 1.0 factor was used to revise 

previously recommended EDWCs for grape. For surface water, revised recommended EDWCs 

are 20.0 μg/L for peak, 13.6 μg/L for annual mean and 9.9μg/L for annual average 

concentrations

Estimated PZRM-GW ground water acute concentration of 2.24 μg/L and chronic concentration 

of 0.82 μg/L are higher than the previously recommended concentration of 1.30x 10-2μg/L for 

citrus (US EPA, 2011; D395784). Therefore, the current EDWCs superseded the previously

recommended EDWCs for groundwater. Recommended EDWCs for human health are 20.0

μg/L (ppb) for the acute dietary (food plus water) exposure analysis and the 1-in-10 year annual 

mean EDWC of 13.6 μg/L (ppb) for the chronic dietary (food plus water) exposure analysis.

V. DEEM-FCID Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were conducted using the 

Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 

DEEM-FCIDTM, Version 3.16, which incorporates consumption data from USDA’s National 

Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). This 

dietary survey was conducted from 2003 to 2008. The data are based on the reported 

consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as 

consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled 

fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and within 

population subgroups, but for acute exposure assessment are retained as individual consumption 

events. Based on analysis of the 2003-2008 WWEIA consumption data, which took into account 
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dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk 

for the following population subgroups: the general U.S. population, all infants (<1 year old), 

children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 

50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure 

is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, significant 

differences in user vs. per capita exposure and risk are identified and noted in the risk 

assessment.

VI. Toxicological Information

On 08-SEP-1998, HED’s Hazard Identification Assessment Review Committee (HIARC) 

evaluated the toxicology database of difenoconazole and re-assessed the RfD established in 

1994, as well as the toxicological endpoints for the dietary and occupational exposure risk 

assessments that were selected in 1994. At this meeting, the HIARC also addressed the potential 

enhanced sensitivity of infants and children from exposure to difenoconazole as required by the 

Food Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998). In July, 

2007, the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected 

by the HIARC since new studies were submitted. RAB1 toxicologists and risk assessment team 

also reevaluated FQPA assessments. The risk assessment team concluded that the default 10x 

FQPA Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary

exposures (M.Sahafeyan, D333320, 09-AUG-07). The relevant endpoints are shown in Table 3.

In accordance with HED’s current policy and EPA’s 2005 Cancer Guidelines, difenoconazole is 

classified as “Suggestive Evidence of Carcinogenic Potential,” based on excessive toxicity

observed at the two highest doses, the absence of tumors at the lower doses and the absence of 

genotoxic effects. A margin-of-exposure (MOE) approach in risk assessment was advocated by

HED’s CPRC in 1994. Use of an MOE approach was reviewed and reaffirmed in 2007 by the 

CPRC Chair (PV Shah, 3/1/07, HED Doc. No. 0054532). Therefore, a separate cancer dietary

assessment is not being conducted for difenoconazole.
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Table 3. Summary of Toxicological Doses and Endpoints for Difenoconazole for Use in Dietary Risk 

Assessments. 

Exposure 

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, for Risk 

Assessment

Study and Relevant 

Toxicological Effects

Acute Dietary 

(All 

populations)

NOAEL = 

25

mg/kg

UFA = 10X

UFH = 10X

FQPA SF = 1X 

aRfD = aPAD = 0.25 

mg/kg/day

Acute Neurotoxicity Study 

in Rats

LOAEL= 200 mg/kg in 

males based on reduced 

fore-limb grip strength in 

males on day 1.

Chronic 

Dietary (All 

populations)

NOAEL = 

0.96

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1X

cRfD = cPAD = 

0.01mg/kg/day

Combined chronic 

toxicity/carcinogenicity 

(rat; dietary) LOAEL = 

24.1/32.8 mg/kg/day (M/F) 

based on cumulative 

decreases in body-weight 

gains.

Cancer (oral, 

dermal, 

inhalation)

Difenoconazole is classified as a Group C, possible human carcinogen with a non-linear (MOE) 

approach for human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah dated 

March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure assessment is protective of 

cancer effects.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population adjusted dose (a = acute, c = chronic). RfD = reference dose. 

VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the aPAD or cPAD, respectively. The following paragraphs are summaries of the 

DEEM-FCID (ver. 2.03) acute and chronic exposure analyses.

Acute and chronic aggregate (food + water) analyses were performed using DEEM-FCID

estimating the dietary exposure of the U.S. population and various population subgroups. The 

results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively. 

The resulting acute food exposure estimates were less than HED’s level of concern (<100% 

aPAD) at the 95th percentile of the exposure distribution for general US population (11 % aPAD) 

and all population sub-groups; the most highly exposed population subgroup was Children 1-2 

years old with 29 % aPAD. The resulting chronic food exposure estimates were less than HED’s 

level of concern (<100% cPAD) for the general U.S. population (27 % cPAD) and all population 

sub-groups; the most highly exposed population subgroup was children 1-2 years old with 78 % 

cPAD. A separate cancer dietary assessment was not conducted for difenoconazole because the 

cancer NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is 

considered protective of all chronic effects including carcinogenicity.

Table 4. Summary of Acute Dietary (Food plus Water) Exposure and Risk for Difenoconazole at the 95th

Percentile.
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Population Subgroup aPAD (mg/kg/day) Exposure (mg/kg/day) %aPAD

General U.S. Population

0.25

0.028053 11

All Infants (< 1 year old) 0.056908 23

Children 1-2 years old 0.071431 29

Children 3-5 years old 0.050407 20

Children 6-12 years old 0.033218 13

Youth 13-19 years old 0.017774 7.1

Adults 20-49 years old 0.020285 8.1

Adults 50-99 years old 0.023527 9.4

Females 13-49 years old 0.020231 8.1

The bolded %aPAD is the highest.

Table 5. Summary of Chronic Dietary (Food plus Water) Exposure and Risk for Difenoconazole.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) %cPAD

General U.S. Population

0.01

0.002685 27

All Infants (< 1 year old) 0.004796 48

Children 1-2 years old 0.007816 78

Children 3-5 years old 0.005781 58

Children 6-12 years old 0.003616 36

Youth 13-19 years old 0.002069 21

Adults 20-49 years old 0.002144 21

Adults 50-99 years old 0.002348 24

Females 13-49 years old 0.002092 21

The bolded %cPAD is the highest.

 

VIII. Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, 100% CT, and empirical or DEEM

default processing factors. The chronic analysis assumed tolerance-level residues for some 

commodities, average field trial residues for the majority of commodities, 100 % CT, and 

empirical or DEEM default processing factors. Therefore, these analyses are considered 

conservative. While they could be significantly refined, further refinement is not warranted as 

estimated risks are not of concern. 

IX. Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted for difenoconazole 

using the DEEM-FCID (ver. 2.03) Model and assumed tolerance-level residues, 100% CT, and 

empirical or DEEM default processing factors. The chronic aggregate dietary risk assessment 

assumed tolerance-level residues for some commodities, average field trial residues for the 

majority of commodities, 100 % CT, and empirical or DEEM default processing factors. The 

resulting acute and chronic aggregate exposure estimates were less than HED’s level of concern. 

For the general U.S. population, the aPAD and cPAD were 11 % and 27 %, respectively. The 
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most highly-exposed population subgroups in the acute (at the 95th percentile of the exposure 

distribution) and chronic analyses were Children 1-2 years old (29 % aPAD) and children 1-2 

years old (78 % cPAD), respectively. 

X. List of Attachments

Attachment 1: DEEM-FCID Acute Residue File

Attachment 2: DEEM-FCID Acute Exposure Estimates

Attachment 3: DEEM-FCID Chronic Residue File

Attachment 4: DEEM-FCID Chronic Exposure Estimates

cc with all attachments: T. Morton (RABIV)

RDI: T. Bloem and W. Cutchin - DESAC (26-January-2013); E. Reaves (30-May-2012)

Petition Number(s): 2F8134

PC Code: 128847

T. Morton:S10838:PY1:(703)305-6691
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Attachment 1: DEEM-FCID Acute Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 

Difenoconazole\Petition 2F8134 Oilseeds 20A\128847 Acute Aug 2013.R08

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 09-25-2013/08:08:55 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.300000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.300000 0.600 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 

0101078000 1AB Carrot 0.500000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.500000 1.000 1.000 

0101079000 1AB Carrot, juice 0.500000 1.000 1.000 

0103015000 1CD Arrowroot, flour 4.000000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 4.000000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 4.000000 1.000 1.000 

0103082000 1CD Cassava 4.000000 1.000 1.000 

0103082001 1CD Cassava-babyfood 4.000000 1.000 1.000 

0103139000 1CD Dasheen, corm 4.000000 1.000 1.000 

0103166000 1CD Ginger 4.000000 1.000 1.000 

0103166001 1CD Ginger-babyfood 4.000000 1.000 1.000 

0103167000 1CD Ginger, dried 4.000000 1.000 1.000 

0103296000 1C Potato, chips 4.000000 0.500 1.000 

0103297000 1C Potato, dry (granules/ flakes) 4.000000 0.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 4.000000 0.500 1.000 

0103298000 1C Potato, flour 4.000000 0.500 1.000 

0103298001 1C Potato, flour-babyfood 4.000000 0.500 1.000 

0103299000 1C Potato, tuber, w/peel 4.000000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 4.000000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 4.000000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 4.000000 1.000 1.000 

0103366000 1CD Sweet potato 4.000000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 4.000000 1.000 1.000 

0103371000 1CD Tanier, corm 4.000000 1.000 1.000 

0103387000 1CD Turmeric 4.000000 1.000 1.000 

0103406000 1CD Yam, true 4.000000 1.000 1.000 

0103407000 1CD Yam bean 4.000000 1.000 1.000 

0301165000 3A Garlic, bulb 0.200000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.200000 1.000 1.000 

0301237000 3A Onion, bulb 0.200000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.200000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.200000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.200000 9.000 1.000 

0301338000 3A Shallot, bulb 0.200000 1.000 1.000 

0302103000 3B Chive, fresh leaves 6.000000 1.000 1.000 

0302198000 3B Leek 6.000000 1.000 1.000 

0302239000 3B Onion, green 6.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 6.000000 1.000 1.000 

0501061000 5A Broccoli 1.900000 1.000 1.000 

0501061001 5A Broccoli-babyfood 1.900000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.900000 1.000 1.000 

0501064000 5A Brussels sprouts 1.900000 1.000 1.000 

0501069000 5A Cabbage 1.900000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.900000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 1.900000 1.000 1.000 

0501083000 5A Cauliflower 1.900000 1.000 1.000 

0501196000 5A Kohlrabi 1.900000 1.000 1.000 

0502063000 5B Broccoli raab 35.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 35.000000 1.000 1.000 

0502117000 5B Collards 35.000000 1.000 1.000 

0502194000 5B Kale 35.000000 1.000 1.000 

0502229000 5B Mustard greens 35.000000 1.000 1.000 

0502318000 5B Rape greens 35.000000 1.000 1.000 

0502389000 5B Turnip, greens 35.000000 1.000 1.000 

0600347000 6 Soybean, seed 0.150000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

13 of 22

0600349000 6 Soybean, soy milk 0.150000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.150000 1.000 1.000 

0600350000 6 Soybean, oil 0.150000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.150000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.150000 1.000 1.000 

0603098000 6C Chickpea, seed 0.080000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.080000 1.000 1.000 

0603099000 6C Chickpea, flour 0.080000 1.000 1.000 

0603348000 6C Soybean, flour 0.150000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.150000 1.000 1.000 

0801374000 8A Tomatillo 0.600000 1.000 1.000 

0801375000 8A Tomato 0.600000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.600000 1.000 1.000 

0801376000 8A Tomato, paste 0.600000 1.600 1.000 

0801376001 8A Tomato, paste-babyfood 0.600000 1.600 1.000 

0801377000 8A Tomato, puree 0.600000 0.500 1.000 

0801377001 8A Tomato, puree-babyfood 0.600000 0.500 1.000 

0801378000 8A Tomato, dried 0.600000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.600000 14.300 1.000 

0801379000 8A Tomato, juice 0.600000 1.500 1.000 

0802148000 8BC Eggplant 0.600000 1.000 1.000 

0802234000 8BC Okra 0.600000 1.000 1.000 

0802270000 8B Pepper, bell 0.600000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.600000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.600000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.600000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.600000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.600000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.600000 1.000 1.000 

0901075000 9A Cantaloupe 0.700000 1.000 1.000 

0901187000 9A Honeydew melon 0.700000 1.000 1.000 

0901399000 9A Watermelon 0.700000 1.000 1.000 

0901400000 9A Watermelon, juice 0.700000 1.000 1.000 

0902021000 9B Balsam pear 0.700000 1.000 1.000 

0902088000 9B Chayote, fruit 0.700000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.700000 1.000 1.000 

0902135000 9B Cucumber 0.700000 1.000 1.000 

0902308000 9B Pumpkin 0.700000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.700000 1.000 1.000 

0902356000 9B Squash, summer 0.700000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.700000 1.000 1.000 

0902357000 9B Squash, winter 0.700000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.700000 1.000 1.000 

1001106000 10A Citron 0.600000 1.000 1.000 

1001107000 10A Citrus hybrids 0.600000 1.000 1.000 

1001108000 10A Citrus, oil 25.000000 1.000 1.000 

1001240000 10A Orange 0.600000 1.000 1.000 

1001241000 10A Orange, juice 0.600000 0.100 1.000 

1001241001 10A Orange, juice-babyfood 0.600000 0.100 1.000 

1001242000 10A Orange, peel 0.600000 1.000 1.000 

1001369000 10A Tangerine 0.600000 1.000 1.000 

1001370000 10A Tangerine, juice 0.600000 0.100 1.000 

1002197000 10B Kumquat 0.600000 1.000 1.000 

1002199000 10B Lemon 0.600000 1.000 1.000 

1002200000 10B Lemon, juice 0.600000 0.100 1.000 

1002200001 10B Lemon, juice-babyfood 0.600000 0.100 1.000 

1002201000 10B Lemon, peel 0.600000 1.000 1.000 

1002206000 10B Lime 0.600000 1.000 1.000 

1002207000 10B Lime, juice 0.600000 0.100 1.000 

1002207001 10B Lime, juice-babyfood 0.600000 0.100 1.000 

1003180000 10C Grapefruit 0.600000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.600000 0.100 1.000 

1003307000 10C Pummelo 0.600000 1.000 1.000 

1100007000 11 Apple, fruit with peel 1.000000 1.000 1.000 

1100008000 11 Apple, peeled fruit 1.000000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 

1100009000 11 Apple, dried 1.000000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 1.000000 8.000 1.000 

1100010000 11 Apple, juice 1.000000 0.040 1.000 

1100010001 11 Apple, juice-babyfood 1.000000 0.040 1.000 

1100011000 11 Apple, sauce 1.000000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 1.000000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

14 of 22

1100129000 11 Crabapple 1.000000 1.000 1.000 

1100173500 11 Goji berry 1.000000 1.000 1.000 

1100210000 11 Loquat 1.000000 1.000 1.000 

1100266000 11 Pear 1.000000 1.000 1.000 

1100266001 11 Pear-babyfood 1.000000 1.000 1.000 

1100267000 11 Pear, dried 1.000000 6.250 1.000 

1100268000 11 Pear, juice 1.000000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 1.000000 1.000 1.000 

1100310000 11 Quince 1.000000 1.000 1.000 

1201090000 12A Cherry 2.500000 1.000 1.000 

1201090001 12A Cherry-babyfood 2.500000 1.000 1.000 

1201091000 12A Cherry, juice 2.500000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 2.500000 1.500 1.000 

1202012000 12B Apricot 2.500000 1.000 1.000 

1202012001 12B Apricot-babyfood 2.500000 1.000 1.000 

1202013000 12B Apricot, dried 2.500000 8.000 1.000 

1202014000 12B Apricot, juice 2.500000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 2.500000 1.000 1.000 

1202230000 12B Nectarine 2.500000 1.000 1.000 

1202260000 12B Peach 2.500000 1.000 1.000 

1202260001 12B Peach-babyfood 2.500000 1.000 1.000 

1202261000 12B Peach, dried 2.500000 8.000 1.000 

1202261001 12B Peach, dried-babyfood 2.500000 8.000 1.000 

1202262000 12B Peach, juice 2.500000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 2.500000 1.000 1.000 

1203285000 12C Plum 2.500000 1.000 1.000 

1203285001 12C Plum-babyfood 2.500000 1.000 1.000 

1203286000 12C Plum, prune, fresh 2.500000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 2.500000 1.000 1.000 

1203287000 12C Plum, prune, dried 2.500000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 2.500000 1.000 1.000 

1203288000 12C Plum, prune, juice 2.500000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 2.500000 1.400 1.000 

1302057000 13B Blueberry 2.500000 1.000 1.000 

1302057001 13B Blueberry-babyfood 2.500000 1.000 1.000 

1304175000 13D Grape 4.000000 1.000 1.000 

1304176000 13D Grape, juice 4.000000 0.200 1.000 

1304176001 13D Grape, juice-babyfood 4.000000 0.200 1.000 

1304179000 13D Grape, wine and sherry 4.000000 1.000 1.000 

1307359000 13G Strawberry 2.500000 1.000 1.000 

1307359001 13G Strawberry-babyfood 2.500000 1.000 1.000 

1307360000 13G Strawberry, juice 2.500000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 2.500000 1.000 1.000 

1400003000 14 Almond 0.030000 1.000 1.000 

1400003001 14 Almond-babyfood 0.030000 1.000 1.000 

1400004000 14 Almond, oil 0.030000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.030000 1.000 1.000 

1400059000 14 Brazil nut 0.030000 1.000 1.000 

1400068000 14 Butternut 0.030000 1.000 1.000 

1400081000 14 Cashew 0.030000 1.000 1.000 

1400092000 14 Chestnut 0.030000 1.000 1.000 

1400155000 14 Hazelnut 0.030000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.030000 1.000 1.000 

1400185000 14 Hickory nut 0.030000 1.000 1.000 

1400213000 14 Macadamia nut 0.030000 1.000 1.000 

1400269000 14 Pecan 0.030000 1.000 1.000 

1400282000 14 Pistachio 0.030000 1.000 1.000 

1400391000 14 Walnut 0.030000 1.000 1.000 

1500025000 15 Barley, pearled barley 0.100000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.100000 1.000 1.000 

1500026000 15 Barley, flour 0.100000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.100000 1.000 1.000 

1500027000 15 Barley, bran 0.100000 1.000 1.000 

1500127000 15 Corn, sweet 0.010000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

1500231000 15 Oat, bran 0.010000 1.000 1.000 

1500232000 15 Oat, flour 0.010000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.010000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.010000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.010000 1.000 1.000 

1500328000 15 Rye, grain 0.010000 1.000 1.000 

1500329000 15 Rye, flour 0.010000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

15 of 22

1500381000 15 Triticale, flour 0.100000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.100000 1.000 1.000 

1500401000 15 Wheat, grain 0.100000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.100000 1.000 1.000 

1500402000 15 Wheat, flour 0.100000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.100000 1.000 1.000 

1500403000 15 Wheat, germ 0.100000 1.000 1.000 

1500404000 15 Wheat, bran 0.100000 1.000 1.000 

2001163000 20A Flax seed, oil 0.100000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.100000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 0.100000 1.000 1.000 

2001336000 20A Sesame, seed 0.100000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.100000 1.000 1.000 

2001337000 20A Sesame, oil 0.100000 1.000 1.000 

2001337001 20A Sesame, oil-babyfood 0.100000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.050000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.050000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.100000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

3100047000 31 Beef, fat 0.100000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.100000 1.000 1.000 

3100048000 31 Beef, kidney 0.100000 1.000 1.000 

3100049000 31 Beef, liver 0.400000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.400000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.100000 1.000 1.000 

3200171000 32 Goat, fat 0.100000 1.000 1.000 

3200172000 32 Goat, kidney 0.100000 1.000 1.000 

3200173000 32 Goat, liver 0.400000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400290000 34 Pork, meat 0.050000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.000 

3400291000 34 Pork, skin 0.100000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.100000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

3400293000 34 Pork, fat 0.100000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.100000 1.000 1.000 

3400294000 34 Pork, kidney 0.100000 1.000 1.000 

3400295000 34 Pork, liver 0.400000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.100000 1.000 1.000 

3500341000 35 Sheep, fat 0.100000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.100000 1.000 1.000 

3500342000 35 Sheep, kidney 0.100000 1.000 1.000 

3500343000 35 Sheep, liver 0.400000 1.000 1.000 

3600222000 36 Milk, fat 0.015000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.015000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.015000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.015000 1.000 1.000 

3600224000 36 Milk, water 0.015000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.015000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.015000 1.000 1.000 

7000145000 70 Egg, whole 0.020000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.020000 1.000 1.000 

7000146000 70 Egg, white 0.020000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.020000 1.000 1.000 

7000147000 70 Egg, yolk 0.020000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.020000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.020000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.020000 1.000 1.000 

9500023000 O Banana 0.200000 1.000 1.000 

9500023001 O Banana-babyfood 0.200000 1.000 1.000 

9500024000 O Banana, dried 0.200000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.200000 3.900 1.000 

9500177000 O Grape, leaves 4.000000 1.000 1.000 

9500178000 O Grape, raisin 6.000000 1.000 1.000 

9500215000 O Mango 0.070000 1.000 1.000 

9500215001 O Mango-babyfood 0.070000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

16 of 22

9500216000 O Mango, dried 0.070000 1.000 1.000 

9500217000 O Mango, juice 0.070000 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.070000 1.000 1.000 

9500245000 O Papaya 0.300000 1.000 1.000 

9500245001 O Papaya-babyfood 0.300000 1.000 1.000 

9500246000 O Papaya, dried 0.300000 1.800 1.000 

9500247000 O Papaya, juice 0.300000 1.500 1.000 

9500283000 O Plantain 0.200000 1.000 1.000 

9500284000 O Plantain, dried 0.200000 3.900 1.000 

Attachment 2: DEEM-FCID Acute Exposure Estimates

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE NHANES 2003-2008 2-Day

Residue file: 128847 Acute Aug 2013.R08 Adjustment factor #2 used.

Analysis Date: 08-13-2014/11:09:38 Residue file dated: 09-25-2013/08:12:04

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.028053 11.22 0.058998 23.60 0.126523 50.61 

All Infants:

 0.056908 22.76 0.086683 34.67 0.238437 95.37 

Children 1-2:

 0.071431 28.57 0.113369 45.35 0.276000 110.40 

Children 3-5:

 0.050407 20.16 0.075530 30.21 0.212138 84.86 

Children 6-12:

 0.033218 13.29 0.058711 23.48 0.139789 55.92 

Youth 13-19:

 0.017774 7.11 0.033809 13.52 0.114904 45.96 

Adults 20-49:

 0.020285 8.11 0.040753 16.30 0.103165 41.27 

Adults 50-99:

 0.023527 9.41 0.052000 20.80 0.125606 50.24 

Female 13-49:

 0.020231 8.09 0.040542 16.22 0.103405 41.36 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

17 of 22

Attachment 3: DEEM-FCID Chronic Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 

Difenoconazole\Petition 2F8134 Oilseeds 20A\128847Chronic Aug 2013 AVG FT WHEAT BARLEY AT 

TOLERANCE.R08

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 08-22-2013/07:59:00 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.300000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.300000 0.600 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 

0101078000 1AB Carrot 0.062000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.062000 1.000 1.000 

0101079000 1AB Carrot, juice 0.062000 1.000 1.000 

0103015000 1CD Arrowroot, flour 1.360000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 1.360000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 1.360000 1.000 1.000 

0103082000 1CD Cassava 1.360000 1.000 1.000 

0103082001 1CD Cassava-babyfood 1.360000 1.000 1.000 

0103139000 1CD Dasheen, corm 1.360000 1.000 1.000 

0103166000 1CD Ginger 1.360000 1.000 1.000 

0103166001 1CD Ginger-babyfood 1.360000 1.000 1.000 

0103167000 1CD Ginger, dried 1.360000 1.000 1.000 

0103296000 1C Potato, chips 1.360000 0.500 1.000 

0103297000 1C Potato, dry (granules/ flakes) 1.360000 0.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 1.360000 0.500 1.000 

0103298000 1C Potato, flour 1.360000 0.500 1.000 

0103298001 1C Potato, flour-babyfood 1.360000 0.500 1.000 

0103299000 1C Potato, tuber, w/peel 1.360000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 1.360000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 1.360000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 1.360000 1.000 1.000 

0103366000 1CD Sweet potato 1.360000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 1.360000 1.000 1.000 

0103371000 1CD Tanier, corm 1.360000 1.000 1.000 

0103387000 1CD Turmeric 1.360000 1.000 1.000 

0103406000 1CD Yam, true 1.360000 1.000 1.000 

0103407000 1CD Yam bean 1.360000 1.000 1.000 

0301165000 3A Garlic, bulb 0.200000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.200000 1.000 1.000 

0301237000 3A Onion, bulb 0.200000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.200000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.200000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.200000 9.000 1.000 

0301338000 3A Shallot, bulb 0.200000 1.000 1.000 

0302103000 3B Chive, fresh leaves 6.000000 1.000 1.000 

0302198000 3B Leek 6.000000 1.000 1.000 

0302239000 3B Onion, green 6.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 6.000000 1.000 1.000 

0501061000 5A Broccoli 0.221000 1.000 1.000 

0501061001 5A Broccoli-babyfood 0.221000 1.000 1.000 

0501062000 5A Broccoli, Chinese 0.221000 1.000 1.000 

0501064000 5A Brussels sprouts 0.029000 1.000 1.000 

0501069000 5A Cabbage 0.029000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 0.029000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 0.221000 1.000 1.000 

0501083000 5A Cauliflower 0.221000 1.000 1.000 

0501196000 5A Kohlrabi 0.029000 1.000 1.000 

0502063000 5B Broccoli raab 5.100000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 5.100000 1.000 1.000 

0502117000 5B Collards 5.100000 1.000 1.000 

0502194000 5B Kale 5.100000 1.000 1.000 

0502229000 5B Mustard greens 5.100000 1.000 1.000 

0502318000 5B Rape greens 5.100000 1.000 1.000 

0502389000 5B Turnip, greens 5.100000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

18 of 22

0600347000 6 Soybean, seed 0.021500 1.000 1.000 

0600349000 6 Soybean, soy milk 0.021500 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.021500 1.000 1.000 

0600350000 6 Soybean, oil 0.021500 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.021500 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.021500 1.000 1.000 

0603098000 6C Chickpea, seed 0.017000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.017000 1.000 1.000 

0603099000 6C Chickpea, flour 0.017000 1.000 1.000 

0603348000 6C Soybean, flour 0.021500 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.021500 1.000 1.000 

0801374000 8A Tomatillo 0.165000 1.000 1.000 

0801375000 8A Tomato 0.165000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.165000 1.000 1.000 

0801376000 8A Tomato, paste 0.165000 1.600 1.000 

0801376001 8A Tomato, paste-babyfood 0.165000 1.600 1.000 

0801377000 8A Tomato, puree 0.165000 0.500 1.000 

0801377001 8A Tomato, puree-babyfood 0.165000 0.500 1.000 

0801378000 8A Tomato, dried 0.165000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.165000 14.300 1.000 

0801379000 8A Tomato, juice 0.165000 1.500 1.000 

0802148000 8BC Eggplant 0.133000 1.000 1.000 

0802234000 8BC Okra 0.600000 1.000 1.000 

0802270000 8B Pepper, bell 0.133000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.133000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.133000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.133000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.133000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.133000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.133000 1.000 1.000 

0901075000 9A Cantaloupe 0.137000 1.000 1.000 

0901187000 9A Honeydew melon 0.137000 1.000 1.000 

0901399000 9A Watermelon 0.137000 1.000 1.000 

0901400000 9A Watermelon, juice 0.137000 1.000 1.000 

0902021000 9B Balsam pear 0.055000 1.000 1.000 

0902088000 9B Chayote, fruit 0.310000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.055000 1.000 1.000 

0902135000 9B Cucumber 0.055000 1.000 1.000 

0902308000 9B Pumpkin 0.031000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.031000 1.000 1.000 

0902356000 9B Squash, summer 0.031000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.031000 1.000 1.000 

0902357000 9B Squash, winter 0.031000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.031000 1.000 1.000 

1001106000 10A Citron 0.208000 1.000 1.000 

1001107000 10A Citrus hybrids 0.208000 1.000 1.000 

1001108000 10A Citrus, oil 25.000000 1.000 1.000 

1001240000 10A Orange 0.208000 1.000 1.000 

1001241000 10A Orange, juice 0.208000 0.100 1.000 

1001241001 10A Orange, juice-babyfood 0.208000 0.100 1.000 

1001242000 10A Orange, peel 0.208000 1.000 1.000 

1001369000 10A Tangerine 0.208000 1.000 1.000 

1001370000 10A Tangerine, juice 0.208000 0.100 1.000 

1002197000 10B Kumquat 0.208000 1.000 1.000 

1002199000 10B Lemon 0.176000 1.000 1.000 

1002200000 10B Lemon, juice 0.176000 0.100 1.000 

1002200001 10B Lemon, juice-babyfood 0.176000 0.100 1.000 

1002201000 10B Lemon, peel 0.176000 1.000 1.000 

1002206000 10B Lime 0.176000 1.000 1.000 

1002207000 10B Lime, juice 0.176000 0.100 1.000 

1002207001 10B Lime, juice-babyfood 0.176000 0.100 1.000 

1003180000 10C Grapefruit 0.120000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.120000 0.100 1.000 

1003307000 10C Pummelo 0.120000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.203000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.203000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.203000 1.000 1.000 

1100009000 11 Apple, dried 0.203000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.203000 8.000 1.000 

1100010000 11 Apple, juice 0.203000 0.040 1.000 

1100010001 11 Apple, juice-babyfood 0.203000 0.040 1.000 

1100011000 11 Apple, sauce 0.203000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

19 of 22

1100011001 11 Apple, sauce-babyfood 0.203000 1.000 1.000 

1100129000 11 Crabapple 0.203000 1.000 1.000 

1100173500 11 Goji berry 0.123000 1.000 1.000 

1100210000 11 Loquat 0.123000 1.000 1.000 

1100266000 11 Pear 0.123000 1.000 1.000 

1100266001 11 Pear-babyfood 0.123000 1.000 1.000 

1100267000 11 Pear, dried 0.123000 6.250 1.000 

1100268000 11 Pear, juice 0.123000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.123000 1.000 1.000 

1100310000 11 Quince 0.123000 1.000 1.000 

1201090000 12A Cherry 0.622000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.622000 1.000 1.000 

1201091000 12A Cherry, juice 0.622000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.622000 1.500 1.000 

1202012000 12B Apricot 0.421000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.421000 1.000 1.000 

1202013000 12B Apricot, dried 0.421000 8.000 1.000 

1202014000 12B Apricot, juice 0.421000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.421000 1.000 1.000 

1202230000 12B Nectarine 0.421000 1.000 1.000 

1202260000 12B Peach 0.421000 1.000 1.000 

1202260001 12B Peach-babyfood 0.421000 1.000 1.000 

1202261000 12B Peach, dried 0.421000 8.000 1.000 

1202261001 12B Peach, dried-babyfood 0.421000 8.000 1.000 

1202262000 12B Peach, juice 0.421000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.421000 1.000 1.000 

1203285000 12C Plum 0.295000 1.000 1.000 

1203285001 12C Plum-babyfood 0.295000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.295000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.295000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.295000 2.600 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.295000 2.600 1.000 

1203288000 12C Plum, prune, juice 0.295000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.295000 1.400 1.000 

1302057000 13B Blueberry 0.495000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.495000 1.000 1.000 

1304175000 13D Grape 0.613000 1.000 1.000 

1304176000 13D Grape, juice 0.613000 0.200 1.000 

1304176001 13D Grape, juice-babyfood 0.613000 0.200 1.000 

1304179000 13D Grape, wine and sherry 0.613000 1.000 1.000 

1307359000 13G Strawberry 0.495000 1.000 1.000 

1307359001 13G Strawberry-babyfood 0.495000 1.000 1.000 

1307360000 13G Strawberry, juice 0.495000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 0.495000 1.000 1.000 

1400003000 14 Almond 0.005000 1.000 1.000 

1400003001 14 Almond-babyfood 0.005000 1.000 1.000 

1400004000 14 Almond, oil 0.005000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.005000 1.000 1.000 

1400059000 14 Brazil nut 0.007000 1.000 1.000 

1400068000 14 Butternut 0.007000 1.000 1.000 

1400081000 14 Cashew 0.007000 1.000 1.000 

1400092000 14 Chestnut 0.005000 1.000 1.000 

1400155000 14 Hazelnut 0.007000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.007000 1.000 1.000 

1400185000 14 Hickory nut 0.007000 1.000 1.000 

1400213000 14 Macadamia nut 0.007000 1.000 1.000 

1400269000 14 Pecan 0.007000 1.000 1.000 

1400282000 14 Pistachio 0.005000 1.000 1.000 

1400391000 14 Walnut 0.007000 1.000 1.000 

1500025000 15 Barley, pearled barley 0.100000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.100000 1.000 1.000 

1500026000 15 Barley, flour 0.100000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.100000 1.000 1.000 

1500027000 15 Barley, bran 0.100000 1.000 1.000 

1500127000 15 Corn, sweet 0.010000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

1500231000 15 Oat, bran 0.010000 1.000 1.000 

1500232000 15 Oat, flour 0.010000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.010000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.010000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.010000 1.000 1.000 

1500328000 15 Rye, grain 0.010000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

20 of 22

1500329000 15 Rye, flour 0.010000 1.000 1.000 

1500381000 15 Triticale, flour 0.100000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.100000 1.000 1.000 

1500401000 15 Wheat, grain 0.100000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.100000 1.000 1.000 

1500402000 15 Wheat, flour 0.100000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.100000 1.000 1.000 

1500403000 15 Wheat, germ 0.100000 1.000 1.000 

1500404000 15 Wheat, bran 0.100000 1.000 1.000 

2001163000 20A Flax seed, oil 0.100000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.100000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 0.100000 1.000 1.000 

2001336000 20A Sesame, seed 0.100000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.100000 1.000 1.000 

2001337000 20A Sesame, oil 0.100000 1.000 1.000 

2001337001 20A Sesame, oil-babyfood 0.100000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.050000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.050000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.100000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

3100047000 31 Beef, fat 0.100000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.100000 1.000 1.000 

3100048000 31 Beef, kidney 0.100000 1.000 1.000 

3100049000 31 Beef, liver 0.400000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.400000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.100000 1.000 1.000 

3200171000 32 Goat, fat 0.100000 1.000 1.000 

3200172000 32 Goat, kidney 0.100000 1.000 1.000 

3200173000 32 Goat, liver 0.400000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400290000 34 Pork, meat 0.050000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.000 

3400291000 34 Pork, skin 0.100000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.100000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

3400293000 34 Pork, fat 0.100000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.100000 1.000 1.000 

3400294000 34 Pork, kidney 0.100000 1.000 1.000 

3400295000 34 Pork, liver 0.400000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.100000 1.000 1.000 

3500341000 35 Sheep, fat 0.100000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.100000 1.000 1.000 

3500342000 35 Sheep, kidney 0.100000 1.000 1.000 

3500343000 35 Sheep, liver 0.400000 1.000 1.000 

3600222000 36 Milk, fat 0.015000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.015000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.015000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.015000 1.000 1.000 

3600224000 36 Milk, water 0.015000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.015000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.015000 1.000 1.000 

7000145000 70 Egg, whole 0.020000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.020000 1.000 1.000 

7000146000 70 Egg, white 0.020000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.020000 1.000 1.000 

7000147000 70 Egg, yolk 0.020000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.020000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.013600 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.013600 1.000 1.000 

9500023000 O Banana 0.200000 1.000 1.000 

9500023001 O Banana-babyfood 0.200000 1.000 1.000 

9500024000 O Banana, dried 0.200000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.200000 3.900 1.000 

9500177000 O Grape, leaves 0.613000 1.000 1.000 

9500178000 O Grape, raisin 0.613000 3.500 1.000 

9500215000 O Mango 0.070000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

21 of 22

9500215001 O Mango-babyfood 0.070000 1.000 1.000 

9500216000 O Mango, dried 0.070000 1.000 1.000 

9500217000 O Mango, juice 0.070000 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.070000 1.000 1.000 

9500245000 O Papaya 0.300000 1.000 1.000 

9500245001 O Papaya-babyfood 0.300000 1.000 1.000 

9500246000 O Papaya, dried 0.300000 1.800 1.000 

9500247000 O Papaya, juice 0.300000 1.500 1.000 

9500283000 O Plantain 0.200000 1.000 1.000 

9500284000 O Plantain, dried 0.200000 3.900 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 412812 & 422170

PC Code: 128847

22 of 22

Attachment 4: DEEM-FCID Chronic Exposure Estimates

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for DIFENOCONAZOLE NHANES 2003-2008 2-day

Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\128847 Difenoconazole\Petition 

2F8134 Oilseeds 20A and Dragonfruit\128847Chronic Aug 2013 AVG FT WHEAT BARLEY AT TOLERANCE.R08

 Adjustment factor #2 used.

Analysis Date 08-13-2014/11:10:27 Residue file dated: 09-25-2013/08:11:21

Reference dose (RfD, Chronic) = .01 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.002685 26.9%

Hispanic 0.002695 26.9%

Non-Hisp-White 0.002650 26.5%

Non-Hisp-Black 0.002711 27.1%

Non-Hisp-Other 0.003075 30.8%

Nursing Infants 0.002931 29.3%

Non-Nursing Infants 0.005629 56.3%

Female 13+ PREG 0.002420 24.2%

Children 1-6 0.006387 63.9%

Children 7-12 0.003360 33.6%

Male 13-19 0.002154 21.5%

Female 13-19/NP 0.001991 19.9%

Male 20+ 0.002238 22.4%

Female 20+/NP 0.002213 22.1%

Seniors 55+ 0.002359 23.6%

All Infants 0.004796 48.0%

Female 13-50 0.002090 20.9%

Children 1-2 0.007816 78.2%

Children 3-5 0.005781 57.8%

Children 6-12 0.003616 36.2%

Youth 13-19 0.002069 20.7%

Adults 20-49 0.002144 21.4%

Adults 50-99 0.002348 23.5%

Female 13-49 0.002092 20.9%

-------------------------------------------------------------------------------