Ethalfluralin Dietary Exposure and Risk Assessment DP Number: 432016 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

DATE: 18-MAR-20 16 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENT ION 

SUBJECT: Ethalfluralin: Acute, Non-Cancer Chronic, and Cancer Dietary (Food and 

Drinking Water) Exposure and Risk Assessments to Support Registration Review. 

PC Code: I 131 0 I DP Ba r code: 0432016 

Decision No.: 510535 Registra tion No.: NA 

Petition No.: NA Regulatory Action: Registration Review 

Risk Assessment Type: Dietary Exposure Case No.: 2260 

TXR No.: NA CAS No.: 55283-68-6 

MRIDNo.: NA 40CFR: §180.4 16 ~ 

FROM: Juli

Risk 

e 

Assessment 

L. Van Alstine, 

Branch 

MPH

6 

, 

(RAB6)

Environmenta

/Health 

l H

Effects 

ealth Scient

Divisio

ist""" 

n (Hi

\ 

D

v.,A_u 

; 7509P) 

~ ~ 

THROUGH: Thurston G. Morton, Chemist V~~~ Jennifer R. Tyler, Chemist ~ ~r 

Dietary Exposure Science Advtsory Council (DESAC) 

HED (7509P) 

And 

Donna S. Davis, Branch Chief 

RAB6/HED (7509P) 

TO: Kelly Ballard, Chemical Review Manager 

Tom Moriarty, Team Leader 

Neil Anderson, Branch Chief 

Registration Division (RD; 7505P) 

Executive Summary 

Acute, chronic non-cancer, and chronic cancer dietary (food and drinking water) exposure and 

risk assessments were conducted using the Dietary Exposure-Evaluation Model software with the 

Food Commodity Intake Database (DEEM-FCID) Version 3.18, which uses food consumption 

data from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition 

Page 1 of25 
Ethalnuralin Dietary Exposure and Risk Assessment DP Number: 432016 

Examination Survey, What We Eat in America, (NHANES/WWElA) from 2003 through 2008. 

The analyses were performed to support Registration Review of the herbicide ethaltluralin, [Nethyi-N-(2-methyl-2-propenyl)-2,6-dinitro-4-(trifluoromethyl)-benzenamine]. 

Acute Dietary Exposure Results and Characterization 

An acute dietary endpoint (i.e., single dose endpoint) for risk assessment was not identified in the 

toxicity database for the general U.S. population; however, an endpoint was selected for females 

13-49 years old and an unrefined acute dietary (food and drinking water) assessment was 

completed for this population subgroup. The acute assessment used tolerance-level residues and 

assumed I 00% crop treated (CT). A modeled estimated drinking water concentration (EDWC) 

of 0.02612 ppm was included directly in the dietary analysis. The acute di etary exposure and 

risk estimate for females 13-49 years old is <1% of the acute population-adjusted dose (aPAD) 

and is below HED's level of concern (LOC). 

Chronic Dietary Exposure Results and Characterization 

An unrefined chronic non-cancer dietary (food and drinking water) assessment for ethaltluralin 

was a lso conducted that used tolerance-level residues and assumed I 00% CT. A modeled 

EDWC of 0.00057 ppm was included directly in the dietary analysis. The chronic dietary 

exposure and risk estimates are < l% ofthe chronic population-adjusted dose (cPAD) for all 

population subgroups and are below HED's LOC. The most highly exposed population 

subgroup was children I to 2 years old. 

Cancer Dietary Exposure Results and Characterization 

Ethalfluralin is classified as a possible human carcinogen with a cancer potency factor (Q I *)of 

8.9 x I o·2 (mg/kg/day)" 1

. A refined ethaltluralin chronic cancer dietary (food and drinking water) 

analysis was conducted using the field trial Y2 lowest level of method validation (LLMV) value 

for all potato commodities, monitoring data generated by USD/\ 's Pesticide Data Program 

(PDP), tolerance-level residues, and average percent crop treated (PCT) data from the Biological 

and Economic Analysis Division (BEAD). A modeled EDWC of0.00036 ppm was included 

directly in the dietary ana lysis. The most highly exposed ad ult population subgroups were adults 

20-49 years old and females 13-49 years old, with cancer dietary (food and drinking water) risk 

estimates of 8.4x 1 o-7

• Drinking water was a driver in the cancer dietary assessment. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i. e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

Page 2 of 25 
Ethalfluralin Dietary Exposure and Risk Assessment DP Number: 432016 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detai l are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 2 1-JUN-2000, web link: 

http://www.regulations.gov/#!documentDetaii :D=EPA-HQ-OPP-2007-0780-0001; or see SOP 

99.6 (20-AUG-1999). 

The most recent dietary risk assessment for ethalfluralin was conducted by C. Swattz (02-NOV2007; D333868) 

II. Residue Information 

Residues of Concern: The residue of concern in crops, for purposes of tolerance enforcement 

and risk assessment, is ethalfluralin only. The residue of concern in drinking water for purposes 

of risk assessment is ethalfluralin only. 

Established Tolerances: Tolerances for residues of ethalfluralin are established at 0.05 ppm 

under 40 CFR § 180.41 6 in/on several crops. There are no registered tolerances for residues in 

livestock commodities (40 CFR § 180.6 (a)(3)). 

Residues Used in the Assessments: Attachment I summarizes the residue values that were used 

in the acute, non-cancer chronic, and chronic assessments. The acute and chronic assessments 

were unrefined and assumed tolerance-level residues (0.05 ppm) and I 00% CT for all 

commodities. 

The cancer assessment was refined and used the field trial !h LLMV value for all potato 

commodities (0.025 ppm), PCT and PDP data for various commodities, and tolerance-level 

residues for all remaining commodities. The !h LLMV value was used for potatoes since all field 

trial residues were below the LLMV of 0.05 ppm. Although PDP data arc avail able for potatoes 

that indicate that there were no detectable residues (2008, 2009; N= 11 60; average !h LOD value= 

0.00 l ppm), the data were not used since the samples were taken near the time of the potato use 

registration and may not reflect current use patterns. 

PDP was specifically designed for risk assessment; analysts prepare samples in a manner similar 

to typical consumer practices, such as washing, coring/pitting, and/or peeling. The PDP samples 

are collected at large-scale distribution centers, just prior to sale in grocery stores, and are more 

likely to reflect "dinner plate" residues. PDP data were used in the cancer assessment for the 

following commodities: soybean grain (20 II ; N=300); soy infant formula (2013; N= l79); 

caru1ed black bean (20 I 0; N=367); canned kidney bean (2008, 2009; N=372); canned pinto bean 

(2009; N=372); garbanzo bean (2009, 2010; N=372); cantaloupe (2003 , 2004; 2005; N= l486); 

watermelon (2010; N=371); cucumber (2009, 2010; N=1474); summer squash (2012, 2013; 

N=895); winter squash (20 11 , 2012; 2013; N= Il15); and peanut butter (2006; N=719). PDP did 

not detect residues ofethalfluralin in any ofthe monitored commodities; therefore, the cancer 

assessment used the average !h LOD value for these commodities as a point estimate. The 

average half LOD value was calculated for each year of PDP data using a Statistical Analysis 

System (SAS) program. An average of these values was then calculated for the years of data of 

Page 3 of25 
Ethal flu rat in Dietary Exposure and Risk Assessment DP Number: 432016 

interest and incorporated into the assessment. The cantaloupe data were translated to honeydew 

melon. The remaining commodities used tolerance-level residues. 

PDP also monitored pesticide residues in catfish in 2008, 2009, and 20 l 0 and in salmon in 2013. 

ln general, pesticide residues would not be expected to be found in fish unless the pesticide 

bioaccumulates or has an aquatic use. To determine whether or not residues are present in fish, 

HED now routinely checks PDP monitoring data regardless of the pesticide's uses and 

physicochemical properties. Residues of ethalfluralin were not detected in the 2008, 2009, and 

20 I 0 catfish samples or in the 2013 salmon samples. As a result, residues in fish were not 

included in the assessment. 

Processing Factors: The acute and chronic assessments use the DEEM default processing factor 

of 1.89x for peanut butter. The processing factor was set to 1 x for peanut butter for the cancer 

assessment since PDP data were used for peanut butter and these data already reflect the effects 

of processing on ethalfluralin residues. For the acute, non-cancer chronic, and cancer 

assessments, the DEEM default processing factor of 6.5x was used for dry potatoes (granules and 

flour). 

Ul. Percent Crop Treated 

BEAD provided a Screening-Level Usage Analysis (SLUA) memorandum entitled, "Screening 

Level Usage Analysis (SLUA) Rep011 for Ethalfluralin (PC Code # 113101 ), in Support of Draft 

Risk Assessment for Registration Review" (Memo, L. Yohannes, 17-JUN-2015). The acute and 

chronic assessments used I 00% CT assumptions for all commodities. The cancer assessment 

incorporated average PCT data for the following commodities: canola/rapeseed ( <2.5%); 

cantaloupe (5%); cucumber (50%); peanut (25%); potato (<1 %); pumpkin (30%); squash (30%); 

sunflower (10%); and watermelon (20%). The remaining commodities in the cancer assessment 

assumed 1 00% CT. 

IV. Drinking Water Data 

The residue of concern for risk assessment in drinking water is ethalfluralin. The drinking water 

residues used in the dietary risk assessment were provided by EFED in the following 

memorandwn: "Ethalfluralin Drinking Water Assessment to Support Registration Review (DP 

Barcode 0429863; PC Code 113101)" (M. Barrett, 24-FEB-2016). Tier 2 EDWCs for 

etha1fluralin were provided by EFED using the Surface Water Concentration Calculator (SWCC) 

and the Pesticide Root Zone Model for GroundWater (PRZM-GW) models. The surface water 

EDWCs were much higher the groundwater EDWCs, which reflects the low leaching potential 

for the strongly adsorbed ethalfluralin molecule. The surface water EDWCs were used in the 

acute, chronic, and cancer dietary (food and drinking water) assessments. The acute EDWCs 

were modeled using the FL cucumber scenario and the chronic and cancer EDWCs were 

modeled using the MS corn scenario as a surrogate for soybeans. 

Page 4 of25 
Ethalnuralin Dietary Exposure and Risk Assessment DP Number; 432016 

Table 1. Maximum Estimated Drin king Water Concentrations for Groundwater and Surface Water 

Sources from the Use of Ethalfluralin. 

DRINKJNC 

WATER SCENARIO (USE) (rate modeled per 

MAXIMUM ESTIMATED DRINKING 

SOURCE WATER CONCENTRATION (EDWC) 

(MODEL year) ( ppb) 

USED) 

Groundwater WI sand (I. 7 lb a.i applied I x per year) Acute 0.0004371 

(PRZM-GW) WI sand (1.7 lb a.i.) Chronic 0.0004371 

Acute: Cucurbits (FL Cucumber scenario; Acute 26. 1 maximum single and seasonal application 

Surface water 

rate of I. 7 lb ail A applied annually)) Chronic (annual) 0.57 

(SWCC) Chronic: Soybeans (MS corn scenario used 

as a surrogate for soybeans; maximum single Chronic/Cancer (30+ and seasonal application rate of 1.31 lb ai/A 

years) 0.36 

applied annually) 

1 Based on a I 00-year sunulat1 on w1th max1mum rate applied every year. For the standard 30-year s1mulat1on the 

max imum acute concentration was 0.000437 ppb with the WI sand scenario. Since a "breakthrough" time was not 

established (the movement of low-level residues into the aquifer was too slow even with I 00-year simulations) the 

chronic value was conservatively set to the same as the acute exposure value. 

V. DEEM-FCID Program and Consumption Information 

Ethaltluralin acute, non-cancer chronic, and cancer exposure assessments were conducted using 

DEEM-FCIO, Version 3. 18, which incorporates consumption data from USDA's 

NHANES/WWEIA from 2003 through 2008. The data are based on the reported consumption of 

more than 20,000 individuals over two non-consecutive survey days. Foods "as consumed" 

(e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit- cooked; 

fresh or N/S; baked; or wheat fl our- cooked; fresh or N/S, baked) using publicly available recipe 

translation files developed jointly by USDNARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population subgroups. 

However, for acute exposure assessment, consumption data are retained as individual 

consumption events. Based on analysis of the 2003-2008 WWEJA consumption data, which 

took into account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the fo llowing population subgroups: the general U.S. population, 

a ll infants (< 1 year old), children 1-2, children 3-5, children 6- 12, youth 13-19, adults 20-49, 

females 13-49, and adults 50-99 years old. 

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total da il y pestic ide exposure for a 

deterministic exposure assessment, or "matched" in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distri bution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commoditi es as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministi c assessments, any signifi cant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment. 

Page 5 of25 
Ethal flural in Dietary Exposure and Risk Assessment DP Number: 432016 

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange j uice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue inta ke estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cP AD. This procedure is perfom1ed for each population subgroup. 

VI. Toxicological Information 

The toxicological database for ethaltluralin is complete and adequate for risk assessment. The 

doses and endpoints selected for dietary exposure and risk assessment for ethalfluralin are shown 

below in Table 2. These endpoints have been confirmed by the risk assessment team as 

appropriate for the current risk assessment. 

Table 2. Ethalfl uralin- Summary of Toxicological Doses and Endpoints for Usc in Dietary Human Healt h 

Risk Assessments. 

Exposure Point of Uncertainty/ Population Adjusted Study and Toxicological Effects Dose for Risk Scenario Departure FQPA SFs Assessment 

Acute Dietary 

(General 

Population, A single dose effect relevant to the general US population including infants and children was not 

including identified in the toxicity studies conducted with ethalfluralin. 

Infants and 

Children) 

Rabbit Dev. Toxicity Study 

MIRD: 00 129057.00250596 

Acute Dietary 

UFA = lOx aRfD = 0.75 

(Females 13-49 NOAEL = 75 UFH = lOx mglkg/day 

years of age) mg/kg/day FQPA SF= aPAD = 0.75 Developmenta l LOAEL = 150 

lx mglkg/day mg/kg/day based on increased 

number of resorptions and 

increased sternal and cranial 

variations 

Dog, Chronic Oral Toxicity Study 

MIRD: 0015337 1. 92062014 

UFA= lOx cRfD = 0.04 LOAEL = 20 mglkg/day based on 

Chronic Dietary NOAEL = 4 UF11 = lOx mglkg/day increased urinary bilirubin, (All 

mg/kg/day FQPA SF= cPAD = 0.04 variations in erythrocyte 

Populations) lx mg/kg/day morphology, increased 

thrombocyte count, and increased 

erythroid series of the bone 

marrow. 

Cancer (oral, Ethalfluralin has been classified as a possible human Rat 2-year chronic/carcinogenicity 

dennal, carcinogen (Group C) based on increased mammary gland study fibro-adenomas & combined adenomas/fibro-adenomas in inhalation) female rats. Q1* = 8.9 x 10·

2 (mg/kg/day)" 1 MIRD:00094776,92062013 

Page 6 of25 
Ethal fl ura I in Dietary Exposure and Risk Assessment DP Number: 432016 

Point of Departure (POD)= A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population adjusted dose (a = acute, c = chronic). 

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCID anal yses estimate the di etary exposure ofthe U.S. 

population and various population subgroups. Table 3 summari zes estimated acute dietary 

exposure and risk for females 13-49 years old; chronic non-cancer risk for the general U.S. 

population, all infants (< 1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years; and cancer risk for the general U.S. 

population onl y, per HED policy. The resulting acute and non-cancer chronic food and drinking 

water exposure estimates were not of concern to HED (51 00% PAD). For the cancer 

assessment, the most highly exposed adult population subgroups we re adults 20-49 years old and 

fema les 13-49 years old, with cancer dietary (food and drinking water) risk estimates of 8.4x I o-7. 

Table 3. Summa ry of Dietary (Food and Drinking Water) Exposure and Risk Estimates for Etbalfluralin. 

Acute Dietary Chronic Dietary1 Cancer-2 (95'h Percentile) 

Population Subgroup Dietary Dietary Dietary 

Exposure %aPAD Exposure %cPAD Exposure Risk 

(mglkg/day) (mglkg/day) (mglkg/day) 

General U.S. Population 0.000 108 <I% 

All Infants(< I year old) 0.000206 < I% 

Ch ildren 1-2 years old 0.000277 <1% 

Children 3-5 years old N/A N/A 0.000236 < I% N/A N/A 

Children 6-1 2years old 0.000 157 < I% 

Youth 13- 19 years old 0.000090 <I% 

Adults 20-49 years old 0.000088 <I% 0.000009 8.4x I 0·

7 

Adults 50+ years old 0.000088 <I% N/A N/A 

Females 13-49 years old 0.001538 < I% 0.000086 < I% 0.000009 8.4x 10·

7 

1 Most h1ghly exposed population subgroup 1s d1splayed m bold. 2 HED reports the most highly exposed adult population subgroup for cancer assessments. 

VIII. Characterization of Inputs/Outputs 

The acute and non-cancer chronic dietary (food and water) risk assessments conducted for 

ethalfluralin are unrefined and used tolerance-level residues and I 00% CT. Additional 

refinements arc not required at this times; however, these assessments could be refined if the 

furure, if needed, using fi eld trial, PCT, or PDP data. 

The cancer dietary (food and water) assessment was refined and used the Y2 LLMV value for all 

potato commoditi es (0.025 ppm), PCT and PDP data for various commodities, and tolerancelevel residues for all remaining commodities. The cancer dietary assessment could be further 

refined with additional PCT data, by translating the available PDP data to similar commodities, 

and/or with fie ld trial data for the commodities that used tolerance-level residues. Additional 

Page 7 of 25 
Ethal flural in Dietary Exposure and Risk Assessment DP Number: 432016 

refinements were not incorporated into the assessment because they were not needed at this time. 

Water is the main driver in the cancer assessment (approximately 76% of the total exposure). 

IX. Conclusions 

The acute and chronic dietary exposure and risk assessments demonstrate that estimated food 

and drinking water exposures are not of concern. Chronic cancer dietary (food and drinking 

water) exposures to ethaltluralin yield a cancer risk estimate of 8.4x l o-7 for adults 20-49 years 

old and females 13-49 years old, the most highly exposed adult population subgroups. HED is 

confident that the assessment does not underestimate risk to the general U.S. population or any 

population subgroup. 

X. List of Attachments 

Attachment I. Residues Used in Acute, Non-Cancer Chronic, and Cancer Assessments 

Attachment 2. Acute Dietary (Food Plus Water) Residue Input File 

Attachment 3. Acute Dietary (Food Plus Water) Risk Assessment Results 

Attachment 4. Chronic Non-Cancer Dietary (Food Plus Water) Input File 

Attachment 5. Chronic Non-Cancer Dietary (Food Plus Water) Risk Assessment Results 

Attachment 6. Chronic Cancer Dietary (Food Plus Water) Input File 

Attachment 7. Chronic Cancer Dietary (Food Plus Water) Risk Assessment Results 

Attachment 8. Chronic Cancer Dietary Assessment Drivers 

Attachment 9. Chroni c Cancer Dietary (Water Only) Risk Assessment Results 

Attachment I 0. Ethaltluralin SLUA 

cc: J. Van Alstine (RAB6) 

RDI: DESAC Reviewers (01-04-2016); D. Davis (02-22-2016) 

J. Van Alstine:S I 0217:PY -S:(703)603-8866:7509P:RAB6 

Page 8 of25 
Ethalnuralin Dietary Exposure and Risk Assessment DP Number: 4320 16 

Attachment 1. Residues Used in Acute, Non-Cancer Chronic, and Cancer Assessments 

Table A. I. Residues Used in Acute, No n-Ca ncer Chronic, and Ca ncer Assessments. 

Acute/Non- Cancer Acute, Non-Ca ncer Chronic, and Cancer 

Ca ncer Chronic Assessments• 

Commodity BS2 Residue No. Detects I Residue Avg. Va lue PCT Data Source No. Yl LOD I Value PF Comments 

(ppm) No. Zeroes (ppm) PCT3 

Potato, chips B 100 < I I 

Potato, dry B 100 < I 6.5 (granules/ flakes) 

The cancer assessment used the half 

Potato, nour B 0.05 100 Y2 LLMV 0.025 < I 6.5 LLMV value since all field trial residues in -- potato were less than the LLMV of0.05 

ppm. Potato, tuber. NB/ 100 < I I 

w/peel PB 

Potato, tuber, w/o NB/ 100 <I I 

peel PB 

Soybean, seed B 100 Soybean 

100 I The cancer assessment used the average Soybean, oil B 100 100 I 

Soybean, nour B 0.05 100 grain PDP o 1300 I o 0.0005 100 I half LOD value from the PDP data. 

data; 2011 Additionally, I 00% CT was used since the Soybean, soy milk B 100 100 I 

commodities are blended and monitoring Soybean, soy Soy infant data (that automatically account for PCT) milk-babyfood or B 0.05 100 formula PDP 0 1179 10 0.0025 100 I 

were used. 

infant data; 2013 

Canned black Canned pinto bean PDP data were used in Bean, black, seed B 0.05 100 bean PDP 0 1367 10 0.00055 100 I 

data; 20 10 the cancer assessment for all dry beans 

Canned except black beans and kidney beans since 

kidney bean pinto beans had the highest average half 

Bean, kidney, seed B 0.05 100 0 13721 0 0.0014 100 I LOD value. Additionally, 100% CT was PDP data; used since the commodities are blended 2008; 2009 

Page 9 of25 
Ethalfluralin Dietary Exposure and Risk Assessment DP Number: 432016 

Table A.l. Residues Used in Acute, Non-Cancer Chronic, and Cancer Assessments. 

Acute/Non- Cancer Acute, Non-Cancer Chronic, and Cancer 

Cancer Chronic Assessments• 

Commodity BS2 Residue No. Detects I Residue Avg. Value PCT Data Source No.~ LOD I Value PF Comments 

(ppm) No. Zeroes (pnm) PCT3 

Bean, broad, seed B 100 100 I and monitoring data (that automatically 

Bean, cowpea, B 100 100 I 

account for PCT) were used. 

seed 

Bean, great B 100 100 I nonhem, seed Canned pinto 

Bean, lima, seed B 0.05 100 bean POP 0 1372 10 0.0015 100 I 

Bean, mung, seed B 100 data; 2009 100 I 

Bean, navy, seed B 100 100 I 

Bean, pink, seed B 100 100 I 

Bean. pinto, seed B 100 100 I 

Guar, seed B 100 100 I 

Chickpea, seed B 100 100 I The cancer assessment used the average 

Chickpea, flour B 100 Garbanzo 100 I half LOD value from the PDP data. 

Lentil, seed B 0.05 100 bean PDP 0 1372 10 0.00 1 100 I Additionally, I 00% CT was used since the 

Pea, dry B 100 data; 2009; 100 I commodities are blended and monitoring 

Pea, pigeon, seed B 100 2010 data (that automatically account for PCT) 100 I were used. 

Cantaloupe NB/ 100 Cantaloupe 5 I PB PDP data; 

NB/ 0.05 2003;2004; 0 11486 10 0.016 

Honeydew melon PB 100 2005 100 I The cancer assessment used average half 

NB/ Watem1elon LOD values from the PDP data for 

Watermelon PB 0.05 100 PDP data; o l 37t I o 0.003 20 I cantaloupe, watermelon, cucumber, 

2010 summer squash, and winter squash. The 

Balsam pear NB 0.05 100 Tolerance -- 0.05 100 I cantaloupe PDP data were translated to 

Chayote, fruit NB 0.05 100 Tolerance -- 0.05 100 I honeydew. The remaining commodities 

Chinese waxgourd NB 0.05 100 Tolerance -- 0.05 100 I used tolerance-level residues. 

NB/ Cucumber 

Cucumber PB 0.05 100 PDP data; 0 11474 10 0.0066 50 I 

2009;20 10 

Page 10of25 
Ethal flural in Dietary Exposure and Risk Assessment DP Number: 4320 16 

Table A. I. Residues Used in Acute, Non-Ca ncer Chronic, and Cancer Assessments. 

Acute/Non- Ca ncer 

Acute, Non-Ca ncer Chronic, and Cancer 

Cancer Chronic Assessments1 

Commodity BS2 Residue No. Detects I Residue Avg. Value PCT Data Source No. YI LOD I Value PCT3 PF Comments 

(ppm) No. Zeroes (ppm) 

Pumpkin NB/ 0.05 100 Tolerance 0.05 30 I PB --

Pumpkin, seed B 0.05 100 Tolerance -- 0.05 30 I 

Summer 

Squash, summer 

NB/ 0.05 100 Squash PDP 0 1895 10 0.0063 30 I PB data; 20 12; 

20 13 

Winter 

Squash, winter NB/ 0.05 100 Squash PDP 0 11115 10 0.003 30 I PB data; 20 II ; 

2012;20 13 

Dill weed B 0.05 100 Tolerance -- 0.05 100 I 

Dill, seed B 0.05 100 Tolerance -- 0.05 100 I 

Flax seed, oil B 0.05 100 Tolerance -- 0.05 100 I 

Rapeseed, oil B 0.05 100 Tolerance 0.05 <2.5 I Used tolerance-level values for the acute, I 

-- Sesame, seed B 0.05 100 Tolerance -- 0.05 100 I chronic non-cancer and cancer 

Sesame, oil B 0.05 100 Tolerance -- 0.05 100 I assessments. 

Safflower, oil B 0.05 100 Tolerance -- 0.05 100 I 

Sunflower, seed B 0.05 100 Tolerance -- 0.05 10 I 

Sunflower, oil B 0.05 100 Tolerance -- 0.05 10 I 

Water, direct, all Acute: -- Used water numbers provided by EFED in 

sources 0.02612 Modeled 0.00036 Memo, M. Barrett, 24-FEB-20 16; Water, indirect, all Chronic: -- Value -- -- --

-- 0.00057 D429863. 

sources 

Peanut B 0.05 100 Tolerance -- 0.05 25 I The acute and chronic assessments used 

Acute/ tolerance-level residues and I OO%CT. The 

Peanut Butter Chronic: cancer assessment used the average half 

Peanut, butter B 0.05 100 PDP data; 0 1719 10 0.00 1 100 1.89x LOD value f;om PDP for peanut butter 

2006 Cancer: and tolerance-level residues for the 

lx remaining commodities. The peanut butter 

Page II of25 
Ethalfluralin Dietary Exposure and Risk Assessment DP Number: 4320 16 

Table A. I. Residues Used in Acute, Non-Cancer Chronic, and Cancer Assessments. 

Acute/NonCa ncer Chronic 

Commodity BS2 Residue 

Value PCT Data Source 

(ppm) 

Peanut, oil B 0.05 100 Tolerance 

--------·-·····- ----- --

1 PF = processing factor. PCT = percent crop treated. 2 BS = blending status. 3 Average PCTdata from Memo, L. Yohannes, 17-JUN-2015. 

Cancer 

No. Detects I Residue 

No. Yz LOD I Value 

No. Zeroes {ppm) 

-- 0.05 

Page 12 of 25 

Avg. 

PCT3 

?-

_ ) 

Acute, Non-Ca ncer Chronic, and Ca ncer 

Assessments• 

PF Comments 

processing factor was set to I x and I 00% 

CT was used for the cancer assessment 

since the PDP data are for peanut butter 

I and already reflect the effects of 

processing on residues and PCT. The 

acute and non-cancer chronic assessments 

use the DEEM default PF of 1.89x. 
Etha1flura1in Dietary Exposure and Risk Assessment DP Number: 4320 16 

Attachment 2. Acute Dietary (Food Plus Water) Residue Input File 

Filename: C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated 

Assessment\Ethalfluralin_ACUTE __ December 21 2015.R08 

Chemical: Ethalfluralin, 113101 

RfD{Chronic): .04 mg/kg bw/day NOEL{Chronic): 4 mg/kg bw/day 

RfD{Acute): .75 mg/kg bw/day NOEL{Acute): 75 mg/kg bw/day Q*= .089 

Date created/last modified : 12-21 - 2015/13:22:37 Program ver. 3 . 16, 03-08 - d 

Comment: Standard UFs of lOOX apply . 

~--------------------- ---- ----- ------------ ----- --------------------- --------- ----

EPA Crop 

Code Grp Commodity Name 

0103296000 1C 

0103297000 1C 

0103297001 lC 

0103298000 lC 

0103298001 lC 

0103299000 lC 

0103299001 lC 

0103300000 1C 

0103300001 lC 

0600347000 6 

0600349000 6 

0600349001 6 

0600350000 6 

0600350001 6 

0603030000 6C 

0603032000 6C 

0603034000 6C 

0603035000 6C 

0603036000 6C 

0603038000 6C 

0603039000 6C 

0603040000 6C 

0603041000 6C 

0603042000 6C 

0603098000 6C 

0603098001 6C 

0603099000 6C 

0603182000 6C 

0603182001 6C 

0603203000 6C 

0603256000 6C 

0603256001 6C 

0603258000 6C 

0603348000 6C 

0603348001 6C 

0901075000 9A 

0901187000 9A 

0901399000 9A 

0901400000 9A 

0902021000 9B 

0902088000 98 

0902102000 9B 

0902135000 9B 

0902308000 9B 

0902309000 9B 

0902356000 9B 

0902356001 9B 

0902357000 9B 

0902357001 9B 

1901144000 19A 

1902143000 19B 

2001163000 20A 

2001319000 20A 

Potato, chips 

Potato, dry {granules/ flakes) 

Potato, dry (granules/ flakes) - b 

Potato, flour 

Potato , flour-babyfood 

Potato , t uber, w/peel 

Potato , tuber, w/peel-babyfood 

Potato , tuber, w/o peel 

Potato, tuber, w/o pee l-babyfood 

Soybean, seed 

Soybean, soy milk 

Soybean, soy milk - babyfood or in 

Soybean, oil 

Soybean, oil- babyfood 

Bean, black, seed 

Bean, broad, seed 

Bean, cowpea, seed 

Bean, great northern, seed 

Bean, kidney, seed 

Bean, lima, seed 

Bean, mung, seed 

Bean, navy, seed 

Bean, pink, seed 

Bean, pinto, seed 

Chickpea, seed 

Chickpea , seed-babyfood 

Chickpea, flour 

Guar, seed 

Guar, seed-babyfood 

Lentil, seed 

Pea, dry 

Pea, dry- babyfood 

Pea, pigeon, seed 

Soybean, flour 

Soybean, flour-babyfood 

Cantaloupe 

Honeydew melon 

\olatermelon 

Watermelon, juice 

Balsam pear 

Chayote, fruit 

Chinese waxgourd 

Cucumber 

Pumpkin 

Pumpkin, seed 

Squash, summer 

Squash, summer- babyfood 

Squash, winter 

Squash, winter-babyfood 

Dill weed 

Dill, seed 

Flax seed, oil 

Rapeseed , oil 

Page 13 of25 

Def Res 

(ppm) 

0.050000 

0 . 050000 

0.050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0 . 050000 

0 .050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0 . 050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0.050000 

0 .050000 

0.050000 

Adj.Factors 

Ill 112 

1.000 

6 .500 

6 . 500 

6 .500 

6 . 500 

1. 000 

1. 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1. 000 

1. 000 

1 . 000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1. 000 

1 . 000 

1.000 

1. 000 

1 . 000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1. 000 

1 . 000 

1. 000 

1. 000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1 . 000 

1 . 000 

1.000 

1. 000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1 . 000 

1 . 000 

1. 000 

1.000 

1 . 000 

1 . 000 

1. 000 

1 . 000 

1 .000 

1 . 000 

1 . 000 

1.000 

1. 000 

1.000 

1 . 000 

1 . 000 

1. 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

Comment 
Ethaltluralin Dietary Exposure and Risk Assessment DP Number: 432016 

2001319001 20A Rapeseed, oil-babyfood 0 . 050000 1 . 000 1.000 

2001336000 20A Sesame, seed 0.050000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.050000 1.000 1.000 

2001337000 20A Sesame , oil 0.050000 1.000 1.000 

2001337001 20A Sesame , oil-babyfood 0.050000 1.000 1 . 000 

2002330000 20B Safflower, o i l 0 . 050000 1.000 1 . 000 

2002330001 20B Safflower, oil-babyfood 0.050000 1. 000 1 . 000 

2002364000 20B Sunflower, seed 0 . 050000 1. 000 1 . 000 

2002365000 20B Sunflower, oil 0 . 050000 1.000 1.000 

2002365001 20B Sunflower, oil- babyfood 0.050000 1. 000 1.000 

8601000000 86A \•later, direct, all sources 0.026120 1 . 000 1.000 

8602000000 86B vlater, indirect, all sources 0.026120 1.000 1.000 

9500263000 0 Peanut 0.050000 1.000 1.000 

9500264000 0 Peanut, butter 0.050000 1.890 1.000 

950026 5000 0 Peanut, oil 0 . 050000 1 . 000 1. 000 

Attachment 3. Acute Dietary (Food Plus Water) Risk Assessment Results 

US EPA 

DEEM- FCID ACUTE Analysis for ETHALFLURALIN, 113101 

Residue file: Ethalfluralin_ACUTE __ December 21 2015 .R08 

ver. 3 . 18, 03-08-d 

NHANES 2003-2008 2-Day 

Adjustment factor #2 used. 

Analysis Date: 12-21-2015/13:25:37 Residue file dated: 12-21-2015/13 :22:37 

NOEL (Acute) = 75.000000 mg/kg body-wt /day 

RAC/FF intake summed over 24 hours 

Run comment: "Standard UPs of 100X apply." 

Summary cal culations--per capita: 

95th Percentile---- 99th Percentile---- ---99.9th Percentile- - --

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

Female 13-49: 

0 . 001538 0.21 48753 0 . 002208 0.29 33960 0 . 003034 0.40 24716 

Page 14 of25 
Ethalnuralin Dietary Exposure and Risk Assessment DP Number: 432016 

Attachment 4. Chronic Non-Cancer Dietary (Food Plus Water) Input File 

Filename: C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated 

Assessment\Ethalfluralin CHRONIC December 21 2015.R08 

Chemical: Ethalfluralin,-113101 --

RfD(Chronicl: .04 mg/kg bw/day NOEL(Chronicl: 4 mg/kg bw/day 

RfO(Acutel: .75 mg/kg bw/day NOEL(Acute): 75 mg/kg bw/day 0 * = . 089 

Date created/last modified : 12-21-2015/13:23:19 Program ver. 3 . 16, 03-08 - d 

Comment: Standard UFs of 100X appl y . 

~---------------------- ------------------ ----------------------- -- ---------

EPA Crop 

Code Grp Commodity Name 

0103296000 1C 

0103297000 1C 

0103297001 1C 

0103298000 1C 

0103298001 1C 

0103299000 1C 

0103299001 1C 

0103300000 1C 

0103300001 1C 

0600347000 6 

0600349000 6 

0600349001 6 

0600350000 6 

0600350001 6 

0603030000 6C 

0603032000 6C 

0603034000 6C 

0603035000 6C 

0603036000 6C 

0603038000 6C 

0603039000 6C 

0603040000 6C 

0603041000 6C 

0603042000 6C 

0603098000 6C 

0603098001 6C 

0603099000 6C 

0603182000 6C 

0603182001 6C 

0603203000 6C 

0603256000 6C 

0603256001 6C 

0603258000 6C 

0603348000 6C 

0603348001 6C 

0901075000 9A 

0901187000 9A 

0901399000 9A 

0901400000 9A 

0902021000 9B 

0902088000 9B 

0902102000 9B 

0902135000 9B 

0902308000 98 

0902309000 9B 

0902356000 9B 

0902356001 98 

0902357000 9B 

0902357001 9B 

1901144000 19A 

1902143000 19B 

2001163000 20A 

2001319000 20A 

Potato, chips 

Potato, dry (granules/ flakes) 

Potato, d r y (granules/ flakes)-b 

Potato, flour 

Potato, flour-ba byfood 

Potato, t u ber, w/peel 

Potato, tuber, w/peel-babyfood 

Potato, tuber, w/o peel 

Potato, tuber, w/o peel-babyfood 

Soybean, seed 

Soybean, soy milk 

Soybean, soy milk-babyfood or in 

Soybean, oil 

Soybean, oil- babyfood 

Bean, black, s e e d 

Bean, broad, seed 

Bean, cowpea, seed 

Bean, great northern, seed 

Bean, kidney, seed 

Bean, lima . seed 

Bean, mung , seed 

Bean, navy, seed 

Bean, pink, seed 

Bean, pinto, seed 

Chickpea , seed 

Chickpea, seed-babyfood 

Chickpea, flour 

Guar, seed 

Guar, seed-bab yfood 

Lentil , seed 

Pea , dry 

Pea, dry-babyfood 

Pea, pigeon, seed 

Soybean, flour 

Soybean, flou r - babyfood 

Cantaloupe 

Honeydew melon 

Watermelon 

Watermelon, juice 

Balsam pear 

Chayote, fruit 

Chinese waxgourd 

Cucumber 

Pumpkin 

Pumpkin, seed 

Squash, summer 

Squash, summer-babyfood 

Squash, winter 

Squash, winter-babyfood 

Dill weed 

Dill, seed 

Flax seed, o i l 

Rapeseed, oil 

Page 15 of 25 

Def Res 

(ppm) 

0.050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0 . 050000 

0.050000 

0.050000 

Adj . Factors 

#1 112 

1. 000 1. 000 

6 . 500 1.000 

6 . 500 1.000 

6 . 500 1.000 

6 . 500 1. 000 

1. 000 1 . 000 

1 . 000 1.000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1 . 000 

1. 000 1. 000 

1. 000 1 . 000 

1. 000 1 . 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

1. 000 1. 000 

1.000 1.000 

1.000 1 . 000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1 . 000 

1 . 000 1.000 

1. 000 1. 000 

1.000 1 . 000 

1.000 1 . 000 

1.000 1 . 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1 . 000 

1. 000 1. 000 

1.000 1 . 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1 . 000 1 . 000 

1. 000 1. 000 

1 . 000 1.000 

1. 000 1. 000 

1.000 1.000 

1.000 1.000 

1. 000 1. 000 

1. 000 1. 000 

Comment 
Ethal flural in Dietary Exposure and Risk Assessment DP Number: 4320 16 

2001319001 20A Rapeseed, oil- babyfood 0 . 050000 1.000 1.000 

2001336000 20A Sesame, seed 0 . 050000 1. 000 1.000 

2001336001 20A Sesame, seed-babyfood 0 . 0 50000 1.000 1.000 

2001337000 20A Sesame, oil 0 . 050000 1.000 l. 000 

20013 37001 20A Sesame, oil-babyfood 0 . 0 50000 1. 000 1.000 

20023 30000 20B Safflower, oil 0 . 0 50000 1. 000 1.000 

2002330001 20B Safflower, oil-babyfood 0 . 050000 1. 000 1 . 000 

2002364000 208 Sunflower, seed 0 . 0 50000 1. 000 1. 000 

2002365000 208 Sunflower, oil 0 . 050000 1. 000 l. 000 

2002365001 20B Sunflower, oil-babyfood 0 . 050000 1. 000 1.000 

8601000000 86A Water, direct, all sources 0 . 000570 1.000 1.000 

8602000000 86B l'iater, indirect, all sources 0 . 000570 1 . 000 1. 000 

9500263000 0 Peanut 0.050000 1.000 1.000 

9500264000 0 Peanut, butter 0 . 050000 1.890 1. 000 

9500265000 0 Peanut, oil 0 . 050000 l. 000 1.000 

Attachment 5. Chronic Non-Cancer Dietary (Food Plus Water) Risk Assessment 

Results 

US EPA 

DEEM-FCID Chronic analysis for ETHALFLURALIN, 113101 

Residue file name: 

Ver. 3.16, 03 - 08 - d 

NHANES 2003-2008 2-day 

C:\Users\j1angsda\Documents\Chemica1s\Ethalfluralin\Dietary\Updated 

Assessment\ Ethalfluralin_CHRONIC __ December 21 2015.R08 

Adj ustment factor U2 used . 

Analysis Date 12-21-2015/13 : 26 : 55 Residue file dated : 12-21-2015/13 : 23:19 

Reference dose (RfD , Ch ronic) = . 04 mg/kg bw/day 

COMMENT 1: Standard UFs of 1 0 0X apply . 

Total e xposu re by population subgroup 

Total Exposure 

Population 

Subgroup 

Total OS Population 

Hispani c 

Non -H isp-White 

Non-Hisp-Bl ack 

Non- Hisp - Other 

Nursing Infants 

Non-Nur sing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Femal e 20+/NP 

Senior s 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13 - 19 

Adults 20-49 

Adults 50-99 

Pemale 13-49 

mg/kg 

body wt /day 

0.000108 

0 . 000107 

0 . 0001 09 

0.000095 

0 . 000128 

0.000096 

0.000256 

0.000108 

0.000246 

0 . 000147 

0 . 000094 

0.000086 

0.000089 

0.000087 

0.000087 

0.000206 

0 . 000086 

0.000277 

0.000236 

0.000157 

0.000090 

0.000088 

0.000088 

0.000086 

Page 16of25 

Percent of 

Rfd 

0.3\ 

0 . 3\ 

0 . 3% 

0 . 2% 

0 . 3% 

0.2% 

0.6% 

0.3% 

0.6\ 

0 .4 \ 

0 .2\ 

0 .2% 

0 .2% 

0 . 2% 

0 . 2\ 

0.5\ 

0.2% 

0 . 7 \ 

0.6\ 

0.4\ 

0.2\ 

0.2\ 

0.2\ 

0.2\ 
Etha\fluralin Dietary Exposure and Risk Assessment DP Number: 432016 

Attachment 6. Chronic Cancer Dietary (Food Plus Water) Input File 

Filename: C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated 

Assessment\Ethalfluralin_CANCER_January 4 2016.R08 

Chemical: Ethalfluralin, 113101 

RfD(Chronic): .04 mg/kg bw/day NOEL(Chronic): 4 mg/kg bw/day 

RfD(Acute): .75 mg/kg bw/day NOEL(Acute): 75 mg/kg bw/day ~ .089 

Date created/last modified: 01-04-2016/13:48:40 Program ver. 3.16, 03-08-d 

----------------------------------------------------------------------------------- EPA Crop 

Code Grp Commodity Name 

0103296000 1C 

0103297000 1C 

0103297001 1C 

0103298000 1C 

0103298001 1C 

0103299000 1C 

0103299001 1C 

0103300000 1C 

0103300001 1C 

0600347000 6 

0600349000 6 

0600349001 6 

0600350000 6 

0600350001 6 

0603030000 6C 

0603032000 6C 

0603034000 6C 

0603035000 6C 

0603036000 6C 

0603038000 6C 

0603039000 6C 

0603040000 6C 

0603041000 6C 

0603042000 6C 

0603098000 6C 

0603098001 6C 

0603099000 6C 

0603182000 6C 

0603182001 6C 

0603203000 6C 

0603256000 6C 

0603256001 6C 

0603258000 6C 

0603348000 6C 

0603348001 6C 

0901075000 9A 

0901187000 9A 

0901399000 9A 

0901400000 9A 

0902021000 9B 

0902088000 9B 

0902102000 9B 

0902135000 9B 

0902308000 9B 

0902309000 9B 

0902356000 9B 

0902356001 9B 

0902357000 9B 

0902357001 9B 

1901144000 19A 

1902143000 19B 

2001163000 20A 

2001319000 20A 

2001319001 20A 

Potato, chips 

Potato, dry (granules/ flakes) 

Potato, dry (granules/ flakes) -b 

Potato, flour 

Potato, flour- babyfood 

Potato, tuber, w/peel 

Potato, tuber, w/peel- babyfood 

Potato, tuber, w/o peel 

Potato, tuber, w/o peel-babyfood 

Soybean, seed 

Soybean, soy milk 

Soybean, soy milk-babyfood or in 

Soybean, oil 

Soybean, oil- babyfood 

Bean, black, seed 

Bean, broad, seed 

Bean, cowpea, seed 

Bean, great northern, seed 

Bean, kidney, seed 

Bean, lima, seed 

Bean, mung, seed 

Bean, navy, seed 

Bean, pink, seed 

Bean, pinto, seed 

Chickpea, seed 

Chickpea, seed- babyfood 

Chickpea, flour 

Guar, seed 

Guar, seed- babyfood 

Lentil, seed 

Pea , dry 

Pea, dry-babyfood 

Pea, pigeon, seed 

Soybean, flour 

Soybean, flour-babyfood 

Cantaloupe 

Honeydew melon 

Watermelon 

Watermelon, juice 

Balsam pear 

Chayote, fruit 

Chinese waxgourd 

Cucumber 

Pumpkin 

Pumpkin, seed 

Squash, summer 

Squash, summer-babyfood 

Squash, winter 

Squash, winter-babyfood 

Dill weed 

Dill, seed 

Flax seed, oil 

Rapeseed, oil 

Rapeseed, oil-babyfood 

Page 17of25 

Def Res 

(ppm) 

0.025000 

0 . 025000 

0.025000 

0.025000 

0.025000 

0.025000 

0.025000 

0.025000 

0.025000 

0.000500 

0.000500 

0.002500 

0.000500 

0.000500 

0.000550 

0.001500 

0.001500 

0.001500 

0.001400 

0.001500 

0.001500 

0.001500 

0 . 001500 

0.001500 

0.001000 

0.001000 

0.001000 

0.001500 

0.001500 

0.001000 

0.001000 

0.001000 

0.001000 

0.000500 

0.000500 

0.016000 

0.016000 

0.003000 

0.003000 

0.050000 

0.050000 

0.050000 

0.006600 

0.050000 

0.050000 

0 . 006300 

0.006300 

0.003000 

0 . 003000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

Adj . Factors 

Ill 112 

1.000 0 . 010 

6.500 0 . 010 

6.500 0 . 010 

6.500 0 . 010 

6.500 0 . 010 

1.000 0.01 0 

1.000 0.01 0 

1.000 0.01 0 

1.000 0 . 010 

1.000 1 . 000 

1.000 1 . 000 

1.000 1 . 000 

l. 000 1. 000 

l. 000 l. 000 

l. 000 l. 000 

l. 000 1. 000 

1. 000 l. 000 

1. 000 l. 000 

l. 000 l. 000 

1 . 000 1.000 

1. 000 l. 000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

l. 000 l. 000 

l. 000 1. 000 

l. 000 l. 000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

1 . 000 1.000 

1.000 1.000 

l. 000 l. 000 

l. 000 l. 000 

1.000 1.000 

1.000 0 . 050 

l. 000 1. 000 

1.000 0 . 200 

1. 000 0 . 200 

1. 000 l. 000 

1.000 1.000 

1. 000 1. 000 

l. 000 0 . 500 

1.000 0 .300 

1. 000 0 . 300 

1.000 0 .300 

1. 000 0 . 300 

1.000 0.300 

1.000 0.300 

1.000 1.000 

1.000 1.000 

1.000 1.000 

l. 000 0 . 025 

1.000 0 . 025 

Comment 
Ethal flural in Dietary Exposure and Risk Assessment DP Number: 4320 16 

2001336000 20A Sesame, seed 0 . 050000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0 . 050000 1.000 1.000 

2001337000 20A sesame, oil 0 . 050000 1.000 1.000 

2001337001 20A Sesame, oil-bab yfood 0 . 050000 1. 000 1. 000 

2002330000 20B Safflower, oil 0 . 0 50000 1. 000 1. 000 

20023 30001 20B Safflower, oil-bab yfood 0 . 0 50000 1. 000 1. 000 

2002364 000 20B Sunflower, seed 0 . 050000 1. 000 0 . 100 

2002365000 20B Sunflower, oil 0 . 050000 1. 000 0.100 

2002365001 20B Sunflower, oil-babyfood 0 . 050000 1. 000 0.100 

8601000000 86A Water, direct, all sources 0 . 000360 1. 000 1.000 

8602000000 86B Water, indirect, all sources 0.000360 1.000 1.000 

9500263000 0 Peanut 0 .050000 1.000 0 .250 

9500264000 0 Peanut, butter 0 .001000 1.000 1.000 

9500265000 0 Peanut, oil 0.050000 1.000 0 .250 

Attachment 7. Chronic Cancer Dietary (Food Plus Water) Risk Assessment Results 

US EPA 

DEEM-FCID Chronic analysis for ETHALFLURALIN , 113101 

Residue file name: 

Ver. 3.16 , 03 - 08-d 

NHANES 2003-2008 2-day 

C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated 

Assessment\Ethalfluralin_CANCER_ January 4 2016.R08 

Analysis Date 01-04-2016/13 :49:35 

0* = 0 . 089 

Adjustment factor U2 used. 

Residue file dated: 01-04-2016/13:48:40 

Total exposure by population subgroup 

Population 

Subgroup 

Total us Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 1 3+ PREG 

Childr e n 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/ NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3 -5 

Children 6-12 

Youth 1 3-19 

Adults 20 - 49 

Adults 50-99 

Pema1e 13 - 49 

Tot al Exposure 

mg/kg 

body wt/day 

0.000010 

0 . 000010 

0 . 000010 

0.000008 

0. 000011 

0.000018 

0.000051 

0.000010 

0.000014 

0.000009 

0.000007 

0.000007 

0.000009 

0.000010 

0 . 000009 

0 . 000041 

0 . 000009 

0 . 00001 6 

0.000013 

0.000009 

0.000007 

0.000009 

0 . 000009 

0.000009 

Page 18 of 25 

Lifetime risk 

(Q* = . 089) 

8.83E-07 

9.06E-07 

8.98E-07 

7.20E-07 

1.02E-06 

1.57E-06 

4.55E-06 

8.46E-07 

1.24E-06 

7.77E-07 

6.20E-07 

6.51E-07 

7.86E-07 

8.77E-07 

8.09E-07 

3.63E-06 

8.39E-07 

1.41E-06 

1.17E-06 

8.15E-07 

6.35E-07 

8.40B- 07 

8.26E-07 

8.40B- 07 
Etha1flura1in Dietary Exposure and Risk Assessment DP Number: 4320 16 

Attachment 8. Chronic Cancer Dietary Assessment Drivers 

US EPA 

DEEM -FCID Chronic analysis for ETHALFLURALIN, 113101 

Residue f i le name : 

ver. 3.16 , 0 3 - 08-d 

NHANES 2003-2008 2-day 

C:\Users\jlangsda\Documen ts\Chemicals\Ethalfluralin\Dietary\Updated 

Assessment\Ethalfluralin_CANCER_Ja n uary 4 2016.R08 

Adj u stmen t factor H2 used . 

Analysis Date 01-04-2016/13 : 50 : 09 

Q* = 0 . 089 

Residue file dated : 01 - 04-2016/13 : 48 : 40 

====================================================== ========================= 

Critical Commodity Contribution Analysis for 

Total US Population 

Total Exposure = . 0000099 mg/kg bw/day 

Crop groups wi t h tota l exposure contrib ution > 1\ 

Foods/Foodforms with exposure con t r i b u tio n > 1% 

Crop group 

Food 

Food form 

Crop Group = (0) Other 

Pean u t (9500263000): 

FoodForm N/S 

To t a l f or crop group 

-----------Ex posure analysis------- ---

mg/kg I %of Totall Lifetime Risk 

body wt/dayj Exposure I (Q*= . 089) 

-----------1-- - ---- --- -1---------- - ---

0 . 0000004 4 . 22% 3 . 73E-08 

-----------l---- --- ---- l--------------

0 . 0000005 5 . 1 5% 4. 55E-08 

Crop Group = (1 ) Root and Tu ber Vegetables 

Potato, tuber, w/o peel (0103300000): 

FoodForm N/S 0 . 0000001 1.18% 1 . 04E- 08 

-----------l-----------l--------------

Total for crop group 0.0000002 1 . 89% 1.67E-08 

Crop Group = (1C) Tuberous and Corm Vegetables 

Potato, tuber, w/o peel (0103300000): 

FoodForm N/S 0 . 0000001 1 . 18% 1 . 04 E-08 

-----------l----------- 1-------------- Total for crop group 0 . 0000002 1 . 89% 1.67E-08 

Crop Group = (6) Legume Vegeta bles (Succulent or Dried ) 

Total for crop group 0 . 0000002 1 . 56% 1 . 38E-08 

Crop Group = (6C) Dried Shelled Pea/Bean (exc Soybean) 

Total for crop group 0.0000002 1. 56% 1.38E-08 

Crop Group = (9) CUrcurbit Vegetables 

Cucumber (0902135000): 

FoodForm N/S 

Honeydew melon (0901187000) : 

FoodForm N/S 

Total for crop group 

Crop Group = (9A) Melons 

Honeydew melon (0901187000) : 

FoodForm N/S 

Total for crop group 

Crop Group = (9B) Squash/Cucumbers 

Cucumber (0902135000): 

FoodForm N/S 

0.0000003 2.75% 2.43E- 08 

0.0000001 1. 48% 1 . 30E-08 

-----------l----------- l --------------

0.0000007 7 . 39% 6 . 5 3E- 08 

0.0000001 1.48% 1 . 30E- 08 

-----------l-----------l--------------

0.0000003 2 . 77% 2 . 44E-08 

0.0000003 2 . 75% 2 . 43E-08 

Page 19 of25 
Ethal flura l in Dietary Exposure and Risk Assessment DP Number: 4320 16 

Total f or crop group 

Crop Group = (20) Oilseeds 

Safflower, o il- babyfood (2002330001) : 

FoodForm N/S 

Total for crop g r oup 

Crop group 

Food 

Food form 

Crop Group = (20A) Rapeseed 

Total for crop g r oup 

Crop Group = (20B) Sunflower 

Safflower, oil-babyfood (2002330001) : 

FoodForm N/S 

Total for crop group 

Crop Group = (86) Water 

----------- l-- ---------l--------------

0 . 0000005 4.63% 4. 08 E- 08 

0.0000003 2 . 7 6% 2 . 44E-08 

-----------1 -----------1-------------- 0 . 0000005 4 . 74% 4 . 19E-08 

-----------Exposure analysis----------

rng/kg I %of Totall Lifetime Risk 

body wt/dayl Exposure I (Q*= . 089) 

-----------1-----------1--------------

0 . 0000001 1. 05% 9 . 23E- 09 

0 . 0000003 2 . 76% 2 .44 E- 08 

-----------1-----------1- ------------- 0 . 0000004 3.69% 3 . 26E-08 

Water, d irect, all sources (8601000000): 

FoodForrn N/S 0 . 00000 48 48 . 36% 4 . 27E-07 

Water , i ndirect , a ll sources (8602000000) : 

FoodForm N/S 0 . 0000027 27 . 61% 2 . 44E-07 

-------------------------------------- -----------1-----------1-------------- Total for crop group 0 . 000007 5 75 . 97% 6 . 71E-07 

Crop Group = (86A) Direct Wa t er 

Water, direct, all sources (8601000000) : 

FoodForm N/S 0 . 000004 8 48 . 36% 4 . 27E-07 

-------------------------------------- -----------1-----------1-------------- Total for crop g roup 0 . 0000048 48.36% 4 . 27E-07 

Crop Group = ( 86B) Indirect \<later 

Water, i ndirect, all sources (8602000000) : 

FoodForm N/S 0 . 0000027 27 . 61% 2.44E-07 

-------------------------------------- -----------1----------- 1- ------------- Total for crop group 0 . 0000027 27 . 6 1% 2 .44E-07 

Total for crop groups l isted above : 0 . 0000096 96 . 71% 8 . 54E-07 

Page 20 of25 
Ethalfluralin Dietary Exposure and Risk Assessment DP Number: 432016 

Attachment 9. Chronic Cancer Dietary (Water Only) Input File and Risk 

Assessment Results 

Filename: C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin\Dietary\Updated 

Assessment\Ethalfluralin_CANCER WATER ONLY_Nov 30 2015 . R08 

Chemical : Ethalfluralin, 113101 

RfD(Chronic): . 04 mg/kg bw/day NOEL(Chronic): 4 mg/kg bw/day 

RfD(Acute): .75 mg/kg bw/day NOEL(Acute) : 75 mg/kg bw/day Q* = . 089 

Date created/last modified: 11-30-2015/11 : 53:03 Program ver. 3.16, 03 - 08-d 

Comment: Standard UFs of lOOX apply . 

EPA Crop Def Res Adj .Factors Comment 

Code Grp Commodity Name (ppm) Ill 112 

---------- ------------------------------- ---------- ------- 8601000000 86A Water, direct, all sources 0 . 000360 1 . 000 1 . 000 

8602000000 868 Water, indirect, all sources 0 . 000360 1 .000 1. 000 

US EPA 

DEEM -FCID Chronic analysis for ETHALFLURALIN, 113101 

Residue file name : 

Ver. 3.16, 03-08-d 

NHANES 2003-2008 2-day 

C:\Users\jlangsda\Documents\Chemicals\Ethalfluralin \Dietary\Updated 

Assessment\Ethalfluralin_CANCER I~ATER ONLY_Nov 30 2015 .R08 

Analysis Date 11-30-2015/11 :53:4 6 

Q• = 0 . 089 

COMMENT 1: Standard UFs of 100X apply. 

Adjustment factor 112 used. 

Residue file dated : 11-30-2015/11:53 : 03 

========= ===•============================== ====a==== =======a • c== ====== =•======= 

Total exposure by popul ati on subgroup 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non -Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13 -50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20 -49 

Adults 50-99 

Female 13 -49 

Total Exposure 

mg/kg 

body wt /day 

0 . 000008 

0.000007 

0 . 000008 

0 . 000006 

0.000009 

0.000007 

0 . 000025 

0.000007 

0.000010 

0 . 000006 

0 . 000005 

0.000006 

0 . 000007 

0 . 000008 

0 . 000007 

0.000019 

0.000008 

0 . 000011 

0 . 000009 

0 . 000007 

0 . 000005 

0.000008 

0 . 000007 

0.000007 

Page 2 1 of25 

Lifetime risk 

(Q• = . 089) 

6 . 71E- 07 

6 .41E- 07 

6.90E-07 

5 . 54E-07 

7 . 73E-07 

6 .07E-07 

2 .23E-06 

6 . 32E- 07 

8.59E- 07 

5.59E- 07 

4.61E-07 

5 . 17E-07 

6 .25E-07 

7 . 05E-07 

6 .49E-07 

1 . 73E-06 

6 .68E-07 

9 .68E-07 

8 .15E-07 

5.88E- 07 

4.89E-07 

6.69E-07 

6 .62E-07 

6.67E-07 
Ethalfluralin Dietary Exposure and Risk Assessment DP Number: 4320 16 

Attachment 10. Ethalfluralin SLUA 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON DC 20460 

JUN I 7 2015 

:><r :;cor C"(l.'lCAl SM LIY 

I, ~D f'Oll UTIOr; PREVEH~ IC II 

;\1E.\10RANDUi\1 

SCH.IECT: Screening Level Usage 1\nulysis (SLLA) Report for Ethalllurali n (PC Code fl 

I 131 0 I). in Support of Druft Risk Assessment for Rcgislr..tlion Rc ,·icw 

FROM: 

THRU: 

I....P,\.,f,;._f!A AA/IIVI ' 

l.iabcth Yohanncs. Biologist r!V · ~v · ~ 

Science and lnfom1ation Analysis Brandt 

Biologicul anti Ecunomil: Analysis Di,·isjon (7503 1') /I_ ,l ) 

Diann Sims. Chief }JJ..tl-ll-it.J)~U\""' Science ln tormntion nnd /\nnlysis Urnnch 

Biological and Economic Annlysis Di\'ision (75031') 

T O: Kelly Bullun.l. Chemical Review Manager 

Risk Management and lmph:menta tion Brnnclt I 

Pesticide Reeva luation Di\'isio n (750SP) 

Th is mcmorwtdum transmits an update o f the Ethaltlurnlin Screening Level L:sage Analysis 

(SLU1\) report completed in 20 I 0 (usage data from 200 I to 2007) with the must recent 

Ethal lluralin SJ.l jA completed in20 15 (usugc tlutu from :!004 tu 2013). 

Ethallluralin is a selective herbicide used for the precmergenec control o f nnnual as~cs anti 

broatlkaf weeds in food and feed crops. It was ti rst n:gistl"J eJ in I 980. UascJ on ;wailnblc data 

from 2004 to 2013, the h ighest reported us<:~gc of c thnl lluralin was o n cucumbers. sq uash. 

pumpkins. dry beans/peas. peanuts. and wntem1clons. as measured by a\'crage annuul percent 

crop treated. In te rms or average unnuul lhs a.i. ap plied. the highest usage was on dry beans/ peas. 

peanuts, s unflowers. so~ beans. untl pumpkins. and \\'utenndons. 

Since the last SLUA in 20 10. there ha\'c been ~:hangcs in ethallluralin usuge ~·n scve r..tl ~:rops. 1\ s 

rncusurcd by overage annual percent crop trcutctl (PCT), there was an incrcaso.: in ethal llw·alin 

usago.: on lour crops and a decrease in usage on four crops. The greatest increases in usage were 

on pumpkins (from 25 to 30 PCT) and squash (from 25 tu 30 PCT). whi le the greatest decrease 

was un sunnowcrs (from 20 to 10 PCT). nu.:rc was a five pcrccnt decline in :l\'cmge annual PCT 

un peanuts t30 to 25 PCT). d ry beanslpeas (from 30to 25 I'CT). and canta loupes (from 10 to 5 

I'CT). As measured by average annunllbs a.i applied. there was an increase in cthullluralin usngc 

on o nly two crops: green bcuns (from 1.000 to 6.000 lbs. u.i.) and potatoes (from 1.000 tu 2.000 

lbs. u.i.). Usuge tlecreusctl on eight other crops. w ith the greatest annual decreases occurring on 

Page 22 of25 
Ethal flu rat in Dietary Exposure and Risk Assessment DP Number: 432016 

:.un lhmc1:- t I"IPIII -1 00.000 ,,, 2011.000 lh:-. :r.i.). peanut:. (!rum 300.000 to ~00.000 b~. a. i. ). anJ 

Stlyhcans ( l'ro111 70.000 h1-IIJ.00t) lh!>. a.i.). 

In the 1110"1 r .. ·ccnt I l \(.~Ill:'). u.;;t:,: .. · "a' nnltmgcr r.:pon.:d on tmr.ms. pca.:hc-; :md cln:rric-; 

\.~:" u:.a)!t: \\a.., n.:pon.:d 1111 .:ab a~-:. :1 <:top'' ith no ucti \ c cmJ UM.' prudut:t registration or 

Scl.'tion I X t:nK-rgciK~ e\l.'lllptitms at tht: tnlW ot' thi~ report. ;o-;otc th:tt u:.agc continues to be 

rcpo rh.:d on !:!rc~.· n h~.·an~. J!rccn pc:ts. :llld pepper-:. :tlthnugh these crops arc also not I.: no\\ n to he 

lisk'J o n ~.·ti\ c mlu~c product rq..ti-;trat on~ or a:- Sl.'l'tion IS cmcq!t:IH.:~ c.xt.:lllptiuns at th is time. 

For quc,titlll-:. co!llllh'llh .tnt! oth.:r th.tgt: rntilrtll.lli<)ll n:qucsb. pka.;l.' contact me at 

:· oh:tllllt:.., lr.t 11 ~.·p.J gu\ 

Page 23 of25 
Ethal tlural in Dietary Exposure and Risk Assessment 

Ethnlnuralin (1131 01) 

Screening Level lJ!'.1gc t\nalysis (SLU/\) 

Dar e: .Junr I I, 20 15 

What is a Sc r<'cni ng Lc\'cl Usngc Analysis (SLUA)? 

DP Number: 4320 16 

i\vaibb(e estimates of pc!Sticid..: usag..: data fnr a particular aeti\'1.! ingredient that is used on 

agricultural crops in the United St:ues. 

• Pesticide usage data obtained from various sources. The data ar..: th..:n mag..:d, ~werugcd. ami 

rounded so that the presented infom1:11ion is not proprict:try. l'usiness confidential. or tmd..: secret. 

\ Vhat docs it contain ? 

• Pesticide usage data fo r a !'ingle acti,·c ingredient only. 

1\gricultur:rlusc sites (crops) th:tt the pt•sticidc is reporll'cl to be us..:d on. 

• Available pcsti..:idc us:tge information fwm t:.s. :.ta ..:~ that prodw.:..: SO% or nwr..: ufa crop. in most 

cases. or less than XO%. in rare cases. depending on the scope of the smvcy and a,·;1ilabl..: rcs\lun.:c~ . 

• :\nnu:tl pcrccm o f crop treated (an-rage & maximum) for ..:ad1 agri..:ultural ..:rop. 

• Average annual pounds oft~c pesticide applied fo r each <~g iculturu l crop (i.e .. fur the states 

surveyed. not for the entire United States). 

\\'hat as~ umpt io s can I make ahout the reported d:tt :~'! 

• nra~e pounds nf :H:Iin• ingredient applied · V:~lucs arc calculnted by merging pesticide usage 

data sources tugcthcr: a\'craging aero:>!' allobsen·ations. then rounding. Nnre: !j TIH• t!Siimmt?d mlul' 

is lcss Than 500. tltt•nthat 1·aluc is lahl'il'd < 5110. f:stimwl'ti mlues hetll'een 501) & < I.OOIJ.IJflflan• 

rounded to I si!!lli}icnnl digit. Estimatt•d mlucs uf/.llflf/.1/IJO ur greata are mwul!'d 111 2 si:.:nificam 

digits.) 

• A n ragc per cent of crop treated · Values arc calculated by merging data sources together: 

a\ ..:raging b) year. a\'cmging across ull years. & rounding to the nearest multiple of 5. ,\ 'nte: (f the 

estimated ml111' is le.u Than 2 5. th(•ntltl! mlue is laln·h·d ·. 2.5. (f I he <'Slimmed ntluc is less them I 

then the I'Uiue i.\' lahelecl < I. 

• ."\ l aximum percent uf crop treated · Value is the single maximum value reported across ull data 

sources. across all years. & roumk d up to the rll.:arcst multi pic nf 5. Not!': (f'tlte t'stimatcd ml11e i.1 

lcs.1 11tan1. 5. Then /he wdut' is lahch·d <1.5. 

What arc the data sources used"! 

• uS DA-N ASS ll'nitcd States Department or i\ gricuhurc· $ \'atiorwl Agricultural Statistics Sen· ice} -

pcsticid~· usage dnta from ~004 to 2013. 

• Printtc pesticide rna rkct rcst'a rch - pc:sticidc u::.ngc dnt<1 from ~004 to 2013. 

• Califor-nia Department of Pesticide Rej.\ulat ion (OPJ{) Pcslicidc c Rcportinl! (Pti H) data fnr 

::!004 to 201 ::!. 

\\'hnt nrc the limitntions to the data'! 

• Additional registered uses may exist but arc not included because the a\'ailablc sur\'cys do not report 

usage (e.g .. small acreage rop~). 

• Lack of reported usage d<~ta for the pesticide on a crop dors not imply /ern us:1ge. 

• Usngc data on a particular site may be noted in data sources. but not qu antifi ed . In th~sc instances. 

the site "ould not he reported in the SUJA. 

• Non-agricuhural usc sites (e.g .. turf. post-han·cst. mosquito control. etc.) arc not reported in the 

SI.U:\. /\ scparat..: request must be made lll rccei,·c these estimat..:s. 

• Stmlc sites show some usc. e\·cn though they arc not on the label. Th i~ usage could he due to 

\'Urious factors. including, but not limited to Section 18 requests. existing stocks of the chemical. 

data collection errors. and experimental usc permits (EuPs). 

Page 24 of25 
EthaiOuralin Dietary Exposure and Risk Assessment DPNumber: 4320 16 

l>u tc: J unc 11 , 2015 

Sc reen in~ Level Estimates or A~riculturul Uses or Ethnlflu ralin ( 113 10 I) 

Sorted Alphuhctica lly 

Rcporli ~ Year~: 200 ~-2 0 13 

r--

f-- ____ ] - --= -1- l'c rcenl C: ;Tre:ll~ 

A\'CrUJ!C A nnual . . ~~~- Average Annual .\<l:uamum C rops Lbs. :\ .1. A.,.,llcd 

I Alfalfn 9.000 < I I <2.5 ~--4------------------------------ -------------- --------~ 

13cans. Green· 6.000 5 25 I .., 

] C;}bbagc' <500 <I J <2.5 1 

~ - Canolu -1.000 ' <2.5 f <2.5 1 

~ -- ------ -------- 5 Cantaloupc:s ___ 5.000 5 I 5 

() Cucnmhcrs 50.11 00 50 , 65 - 7 -- .Q9· Hcans/Pcns , _____ 6_o_o_.o_o_o_l ______ 2,_· ___ _ -t____,O I 

s Pca nut~ :?oo.ooo ~s -to - C) Peas. (irccn · ..;..500 I < I <2.5 -- --- i - r- ~::;-z-1 I 0 Pc 1~ · __ _ 

I I j Pota toes __ 

p 

1:> 

1-t 

!~kins 

Sovbcans 

Squash 

____ 500_'------------<__._~ 

2.000 < I ¥oi ~~:~~o ·r-~---------- ~~ I J.S1 

10.000 30 35 

10 l 20 

20 l 35 

15 Sun flo" crs I :!00.000 r~-. ~,a~ ,, c~lo -s--~---------~:?0.00Cl~j ________ __ -

'Ill ,\ I.I.IIJ " 'ur'.:' mduJ'" ~[) -1\,\~~ (l ;nllctf ~I.IIC\ f)c(l,lrllllcflllll .\ t• nwltu ·~ 'JIIIlllal t\ l!rl(llhllr.IJ ~t.lll,lll \ ~Cn ll.:<:) 

Privm,• Pc•lktdc :-!:trl.,·l Rc c.trd1 

:\II numl>.-r• ·"" r<'unJcJ. 

500: k" th.tn 5CKI J'<'UOJ, <•f J(l l\.: m;_:r.:J1nll 

~ 5 1<-" 1h.m ~.5 p~r.-.-u t 1•f .-wp '' Uc-;11.:J 

· I 1~ .. , th.1n I pen.'"' Ill nf "·rnp '' lr-.·.th.•t.l 

Page 25 of25