# Patent

## Title
Dietary supplement system for multifunctional anti-aging management and method of use

## Abstract

A dietary supplement system includes a dietary supplement composition for oral administration by an individual in the morning, the composition, including (a) a telomere maintenance complex including: Purslane extract (aerial parts); Turmeric rhizome extract (95% curcuminoids); Quercetin dehydrate, Cayenne pepper fruit; Vanadium (as vanadyl sulfate); Fenugreek seed; Astragalus root extract, Omega fatty acid complex including linoleic acid; alpha-linolenic acid; oleic acid borage seed oil gamma-linolenic acid), evening primrose oil fish body oil (eicosapentaenoic acid; docosahexaenoic acid); (b) a calorie restriction mimetics and gene expression complex including Trans-resveratrol (from Polygonum cuspidatum root extract); Pterostilbene Fisetin 50% (Buxus microphlla Sieb (stem and leaf; Alpha lipoic acid, Coenzyme Q-10, Betaine HCl, Sulfur (from methylsulfonylmethane); L-Carnitine tartrate; L-Carnitine HCl, and (c) a free radical scavenger complex, including Green tea leaf extract catechin and polyphenols); Anthocyanins (from bilberry fruit and grape skin extracts).

## Background
CROSS REFERENCE TO RELATED APPLICATION
This application claims the benefit under 35 USC 119(e) provisional patent application Ser. No. 61/534,673, filed Sep. 14, 2011, which is hereby incorporated by reference in its entirety.


FIELD OF THE INVENTION
This invention relates to a dietary supplement system for multifunctional anti-aging management and method of use.
BACKGROUND OF THE INVENTION
The aging process is believed to relate to the failure of cell components such as the cell nucleus to continue to replicate otherwise healthy cells. This is believed to occur as a result of damage which occurs to essential cell components resultant of decrease in levels of key chemical agents or substances involved in cellular regulation and production. These agents will typically diminish as a result of reduction in efficiency over time of glands and organs in the human body. Reductions in such key chemical agents are believed to cause damage to the RNA and DNA in each cell nucleus which thereby reduces the ability of the cell to reproduce itself which ultimately brings on the aging process which yet further accelerates the decrease in body's production of the key agents. Therefore, the essential problem in anti-aging management is that of maintaining appropriate levels of key metabolic agents so that the genetic material within each cell will not become damaged or otherwise lose efficiency.
Therefore, it is desirable to have improved dietary supplement compositions that provide nutrients and substances to effectively support optimal cellular functions for the purpose of anti-aging management at both the cellular and organ levels.
SUMMARY OF THE INVENTION
A dietary supplement system includes a first dietary supplement composition for oral administration by an individual in the morning, said first composition, comprising: (a) a telomere maintenance complex comprising: Purslane extract (aerial parts), 4-6 mg; Turmeric rhizome extract (95% curcuminoids), 20-30 mg; Quercetin dehydrate, 12-18 mg; Cayenne pepper fruit, 8-12 mg; Vanadium (as vanadyl sulfate), 20-30 mcg; Fenugreek seed, 20-30 mg; Astragalus root extract, 8-12 mg; Omega fatty acid complex, 160-240 mg, including linoleic acid (10.6%), alpha-linolenic acid (1.3%), oleic acid (1.6%), borage seed oil (10% gamma-linolenic acid), evening primrose oil (4.8% GLA), fish body oil (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid); (b) a calorie restriction mimetics and gene expression complex comprising: Trans-resveratrol (from Polygonum cuspidatum root extract), 1.6-2.4 mg Pterostilbene (99%), 1.6-2.4 mg; Fisetin 50% (Buxus microphlla Sieb (stem and leaf)), 1.6-2.4 mg; Alpha lipoic acid, 8-12 mg; Coenzyme 0-10, 4-6 mg; Betaine HCl, 3.2-4.8 mg; Sulfur (from methylsulfonylmethane), 1-1.5 mg; L-Carnitine tartrate, 8-12 mg; L-Carnitine HCl, 4-6 mg; and (c) a free radical scavenger complex, comprising: Green tea leaf extract (40% catechin and polyphenols), 40-60 mg Anthocyanins (from bilberry fruit and grape skin extracts), 4-6 mg


DETAILED DESCRIPTION OF THE INVENTION
In one embodiment, the present invention provides a dietary supplement system for supporting multifunctional anti-aging management. In one embodiment, the nutritional supplement system comprises two dietary supplement compositions, each for oral administration by an individual at a specific time of a day.
In one embodiment, each of the two dietary supplement compositions comprises multiple sub-functional groups of components, including telomere maintenance complex, calorie restriction mimetics and gene expression complex, free radical scavenger complex, DNA repair complex, stem cell maintenance complex, and cell regulation complex. Furthermore, the dietary supplement compositions also comprise multiple vitamins and minerals. One of the two supplement compositions is designated for oral administration in the morning, and hence is referred to as AM dietary supplement composition, or AM composition hereinafter, and the other supplement composition is designated for oral administration in the evening, and hence is referred to as PM dietary supplement composition, or PM composition hereinafter.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one having ordinary skills in the art to which the invention belongs. It should also be understood that various individual components used herein may have more than one type of properties.
In the dietary supplement compositions, telomere maintenance complex comprises a group of components that individually and/or jointly support maintaining telomere of the chromosome. The telomere maintenance complex includes, but not limited to, purslane extract (aerial parts), turmeric rhizome extract containing curcuminoids, quercetin dehydrate, cayenne pepper fruit, vanadium, fenugreek seed, astragalus root extract, valerian root, omega fatty acid complex including linoleic acid, alpha-linolenic acid, and oleic acid, borage seed oil, evening primrose oil and fish body oil.
The calorie restriction mimetics and gene expression complex comprises a group of components that individually and/or jointly support calorie restriction mimetics and gene expression. The calorie restriction mimetics and gene expression complex includes, but not limited to, trans-resveratrol, such as from extract of polygonum cuspidatum root or grape skin, pterostilbene, fisetin, alpha lipoic acid, coenzyme Q-10, betaine HCl, sulfur, such as from methylsulfonylmethane, L-carnitine tartrate, L-carnitine HCl, acetyl-L-carnitine, and avocado extract.
The free radical scavenger complex comprises a group of components that individually and/or jointly function as antioxidant and reduce free radicals. The free radical scavenger complex includes, but not limited to, green tea leaf extract containing catechin and polyphenols, anthocyanins such as from bilberry fruit and grape skin extracts, ginkgo biloba leaf extract containing ginkgo flavonglycosides and sesquiterpene lactones, cruciferous vegetable concentrate (broccoli, kale, radish) containing glucosinolates, grape skin extract containing total phenolics, tomato lycopene extract containing lycopene, rosemary extract (aerial parts), pycnogenol (pine bark extract), lutein such as from marigold flower extract, and green barley grass (aerial parts).
The DNA repair complex comprises a group of components that individually and/or jointly support DNA repairing in both nuclei and mitochondria. The DNA repair complex includes, not limited to, water extract of uncaria tomentosa containing carboxy alkyl esters, N-acetyl-cysteine, inositol hexaphosphate, and melatonin.
The stem cell maintenance complex comprises a group of components that individually and/or jointly support optimal maintenance of stem cells and gene expression. The stem cell maintenance complex includes, but not limited to, chlorella algae, spirulina algae, klamath blue-green algae, fuxoxanthin seaweed (whole plant), nori seaweed extract or brown seeweed extract.
The cell regulation complex comprises a group of components that individually and/or jointly support optimal cell regulation. The cell regulation complex includes, but not limited to, gotu kola leaf, phosphatidyl choline such as from soy lecithin, DMAE bitartrate, cordyceps sinensis mushroom extract containing cordyceptic acid, royal jelly 3× containing 10-HDA, I-glutamine, taurine, L-phenylalanine, L-tyrosine, inositol, L-arginine, L-ornithine, guarana seed extract, probiotic blend (lactobacillus acidophilus, lactobacillus plantarum, bifidobacterium bifidum and lactobacillus casei), amylase, neutral protease, cellulase, lactase, and lipase.
Multiple vitamins in the dietary supplement compositions include, but not limited to, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, biotin, and pantothenic acid.
The minerals in the dietary supplement compositions include, but not limited to, iodine, calcium, zinc, selenium, copper, manganese, chromium, and molybdenum. Optionally, the minerals may further include transitional metal trace elements such as iridium, rhodium, ruthenium, and/or other transitional metal trace elements.
In addition to the active components described above, each composition may further include pharmaceutically acceptable medium. Pharmaceutically acceptable medium is known to those of ordinary skilled in the art. In one exemplary embodiment, the medium includes microcrystalline cellulose, croscarmellose sodium, stearic acid, calcium silicate, magnesium stearate, silica and film coat ingredients such as hypromellose, hydroxypropyl cellulose, and polyethylene glycol. The dietary supplement compositions can be made into various forms suitable for oral administration, for example powder, granules, capsules, tablets, or liquid.
In the AM and PM dietary supplement compositions, each sub-functional group may have some differences in the components described above, and the amount or concentration of individual components may be different, since the effects and needs between the two compositions provided at different times of a day may be different.
In one exemplary embodiment, the AM and PM dietary supplement compositions and the preferred amount of individual components are provided below in Table 1 and Table 2, respectively. It is noted that the amount of individual components is defined as the amount in one dosage or the amount of per serving, which can be contained in one or more capsules or tablets. For example, 20 to 30 mg of taurine in one dosage can be provided in one or two capsules. The size and number of capsules may depend on the manufacturability, which may further depend on the properties of the components and the pharmaceutically acceptable medium used therein.







TABLE 1







AM Dietary Supplement Composition









Amount Per


Components
Serving











Telomere Maintenance Complex










Purslane extract (aerial parts)
4-6 
mg


Turmeric rhizome extract (95% curcuminoids)
20-30 
mg


Quercetin dihydrate
12-18 
mg


Cayenne pepper fruit
8-12 
mg


Vanadium (as vanadyl sulfate)
20-30 
mcg


Fenugreek seed
20-30 
mg


Astragalus root extract
8-12 
mg


Omega fatty acid complex including linoleic 
160-240 
mg


acid (10.6%), alpha-linolenic acid (1.3%), oleic acid 




(1.6%)), borage seed oil (10% gamma-linolenic acid), 




evening primrose oil (4.8% GLA), fish body oil (4.5% 




eicosapentaenoic acid, 3.0% docosahexaenoic acid)




Calorie Restriction Mimetics and




Gene Expression Complex




Trans-resveratrol (from Polygonum cuspidatum
1.6-2.4 
mg


root extract)




Pterostilbene (99%)
1.6-2.4 
mg


Fisetin 50% (Buxus microphlla Sieb (stem and leaf))
1.6-2.4 
mg


Alpha lipoic acid
8-12 
mg


Coenzyme Q-10
4-6 
mg


Betaine HCl
3.2-4.8 
mg


Sulfur (from methylsulfonylmethane)
1-1.5 
mg


L-Carnitine tartrate
8-12 
mg


L-Carnitine HCl
4-6 
mg


Free Radical Scavenger Complex




Green tea leaf extract (40% catechin and polyphenols)
40-60 
mg


Anthocyanins (from bilberry fruit and grape 
4-6 
mg


skin extracts)




Ginkgo biloba leaf extract (24% ginkgo 
40-60 
mg


flavonglycosides, 6% sesquiterpene lactones)




Green barley grass (aerial parts)
20-30 
mg


DNA Repair Complex




water extract of uncaria tomentosa
100-150 
mg


(containing carboxy alkyl esters)




N-acetyl-cysteine
10-15 
mg


Inositol hexaphosphate
1.6-2.4 
mg


Stem Cell Maintenance Complex




Chlorella algae
20-30 
mg


Spirulina algae
40-60 
mg


Klamath blue-green algae
60-90 
mg


Fuxoxanthin seaweed (whole plant)
20-30 
mg


Nori seaweed extract
1.6-2.4 
mg


Cell Regulation Complex




Gotu kola leaf
8-12 
mg


Phosphatidyl choline (from soy lecithin)
20-30 
mg


DMAE bitartrate
20-30 
mg


Cordyceps sinensis mushroom extract 
10-15 
mg


(1% cordyceptic acid)




Royal jelly 3X (5% 10-HDA)
8-12 
mg


L-Glutamine
40-60 
mg


Taurine
20-30 
mg


L-Phenylalanine
20-30 
mg


L-Tyrosine
20-30 
mg


Guarana seed extract (20% caffeine)
32-48 
mg


Amylase
480-720 
units


Neutral protease
120-180 
units


Cellulase
4-6 
units


Lactase
80-120 
units


Lipase
2.6-3.9 
units


Vitamins




Vitamin A (as retinyl palmitate and 85% as 
1,440-2,160 
IU


beta-carotene)




Vitamin C (as ascorbyl palmitate and ascorbic acid)
80-120 
mg


Vitamin D (as cholecalciferol)
32-48 
IU


Vitamin E (as d-alpha tocopheryl succinate and 
40-60 
IU


from mixed natural tocopherols)




Vitamin K (as phytonadione)
60-90 
mcg


Thiamin (as thiamin HCl)
4-6 
mg


Riboflavin (as riboflavin and riboflavin-5-phosphate)
3.2-4.8 
mg


Niacin (as niacinamide and niacin)
56-84 
mg


Vitamin B6 (as pyridoxine HCl and pyridoxal 
9.6-14.4 
mg


5-phosphate)




Folate (as folic acid)
40-60 
mcg


Vitamin B12 (as cyanocobalamin)
64-96 
mcg


Biotin
40-60 
mcg


Pantothenic acid (as D-calcium pantothenate)
9.6-14.4 
mg


Minerals




Iodine (as potassium iodide and from kelp)
24-36 
mcg


Calcium (as calcium carbonate and citrate)
240-360 
mg


Zinc (as zinc glycinate)
1.6-2.4 
mg


Selenium (as selenomethionine)
24-36 
mcg


Copper (as copper lysinate)
0.16-0.24 
mg


Manganese (as manganese gluconate)
0.16-0.24 
mg


Chromium (as chromium polynicotinate)
40-60 
mcg


Molybdenum (as sodium molybdate)
6.4-9.6 
mg


Transitional metal trace elements including 
10-90 
μg


iridium, rhodium, ruthenium
















TABLE 2







PM Dietary Supplement Composition









Amount Per


Component
Serving












Telomere Maintenance Complex




Purslane extract (aerial parts)
4-6 
mg


Turmeric rhizome extract (95% curcuminoids)
20-30 
mg


Quercetin dihydrate
12-18 
mg


Cayenne pepper fruit
8-12 
mg


Vanadium (as vanadyl sulfate)
16-24 
mcg


Fenugreek seed
16-24
mg


Valerian root
24-36 
mg


Omega fatty acid complex including linoleic acid 
160-240 
mg


(10.6%), alpha-linolenic acid (1.3%), oleic acid 




(1.6%), borage seed oil (10% gamma-linolenic acid), 




evening primrose oil (4.8% GLA), fish body oil 




(4.5% eicosapentaenoic acid, 3.0% docosahexaenoic 




acid) Calorie Restriction Mimetics and Gene




Expression Complex




Trans-resveratol (as Polygonum cuspidatum root 
1.6-2.4 
mg


extract or grape skin extract)




Pterostilbene
1.6-2.4 
mg


Fisetin 50% (Buxus microphlla Sieb (stem and leaf))
1.6-2.4 
mg


Alpha-lipoic acid
8-12 
mg


Coenzyme Q10
2.8-4.2
mg


Betaine (as betaine-HCl)
2-3 
mg


Sulfur (from methylsulfonylmethane)
0.8-1.2 
mg


L-Carnitine tartrate
8-12 
mg


Acetyl-L-carnitine
4-6 
mg


Free Radical Scavenger Complex




Cruciferous vegetable concentrate (broccoli, 
32-48 
mg


kale, radish) (2% glucosinolates)




Grape skin extract (37% total phenolics)
16-24 
mg


Tomato lycopene extract (20% lycopene)
1.6-2.4 
mg


Rosemary 4:1 extract (aerial parts)
2.6-3.9 
mg


Pycnogenol (pine bark extract)
1.32-1.98 
mg


Lutein (from marigold flower extract)
0.64-0.96 
mg


Green barley grass
8-12 
mg


DNA Repair Complex




Water extract of uncaria tomentosa (containing 
100-150 
mg


carboxy alkyl esters)




Inositol hexaphosphate
1.6-2.4 
mg


N-Acetyl cysteine
6.4-9.6 
mg


Melatonin
0.4-0.6
mg


Stem Cell Maintenance Complex




Chlorella algae
20-30 
mg


Spirulina algae
12-18 
mg


Klamath blue green algae
36-54 
mg


Fucoxanthin seaweed (whole plant)
20-30 
mg


Brown seaweed extract
4-6 
mg


Cell Regulation Complex




Phosphatidylcholine (from soy lecithin)
16-24 
mg


Cordyceps sinensis mushroom extract 
6.6-9.9 
mg


(1% cordycepic acid)




Royal jelly 3x (5% 10-HDA)
7.2-10.8 
mg


Inositol
40-60 
mg


L-Glutamine
200-300 
mg


L-Arginine (as L-arginine HCl)
128-192 
mg


L-Ornithine (as L-ornithine HCl)
96-144 
mg


Taurine
12.8-19.2 
mg


L-Tyrosine
16-24 
mg


Probiotic blend including Lactobacillus acidophilus, 
40-60 
mil-


Lactobacillus plantarum, Bifidobacterium bifidum

lion 


and Lactobacillus casei

CFU


Amylase
320-480 
units


Neutral protease
80-120
units


Lactase
52-78 
units


Lipase
12.8-19.2 
units


Vitamins




Vitamin A (as retinyl palmitate and 85% from 
1,120-1,680 
IU


natural mixed carotenoids)




Vitamin C (as ascorbic acid and ascorbyl palmitate)
160-240 
mg


Vitamin D (as cholecalciferol)
24-36
IU


Vitamin E (as d-alpha-tocopheryl succinate and from 
32-48 
IU


mixed natural tocopherols)




Vitamin K (as phytonadione)
60-90 
mcg


Thiamin (as thiamin HCl)
2-3 
mg


Riboflavin (as riboflavin and riboflavin-5-phosphate)
4-6 
mg


Niacin (as niacinamide and niacin)
56-84 
mg


Vitamin B6 (as pyridoxine HCl and 
6-9 
mg


pyridoxal-5-phosphate)




Folate (as folic acid)
64-96 
mcg


Vitamin B12 (as cyanocobalamin)
96-144 
mcg


Biotin
32-48 
mcg


Pantothenic acid (as D-calcium pantothenate)
16-24 
mg


Minerals




Iodine (as potassium iodide and from kelp)
9.6-14.4 
mcg


Magnesium (as magnesium oxide and glycinate)
106-159 
mg


Zinc (as zinc glycinate)
1.2-1.8 
mg


Selenium (as selenomethionine)
19.2-28.8 
mcg


Copper (as copper lysinate)
0.08-0.12 
mg


Manganese (as manganese gluconate)
0.08-0.12 
mg


Chromium (as chromium polynicotinate)
32-48 
mcg


Molybdenum (as sodium molybdate)
6.4-9.6 
mcg


Transitional metal trace elements including 
10-90
μg


iridium, rhodium, ruthenium











Preferably, the AM dietary supplement composition is orally administered in the morning, and the PM dietary supplement composition is orally administered in the evening, for example at the bed time. Preferably, the dietary supplement compositions are administered daily as dietary or nutritional supplements. The compositions can be taken with or without food.
The unique combination of the above described telomere maintenance complex, calorie restriction mimetics and gene expression complex, free radical scavenger complex, DNA repair complex, stem cell maintenance complex, and cell regulation complex provides synergetic effects for optimal cellular function. The synergetic effects provide desired calorie restriction mimetics, reduce age related deteriorations in telomere maintenance, stem cell function, cell regulation and gene expression, reduce free radicals at cellular level, and enhance DNA repair in both nuclei and mitochondria. Moreover, the supplement compositions, through various components and their combination, further have anti-inflammation and anti-oxidation properties, and desired functions in regulating glycation and methylation. Therefore, the dietary supplement compositions provide a multifunctional and effective anti-aging management system.
The following example further describes and demonstrates embodiments within the scope of the present invention. The examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.
Example 1
An AM dietary supplement composition shown in Table 3 below was prepared, with the processes known in the art. The amount per serving described was provided in two capsules.







TABLE 3







Example AM Dietary Supplement Composition









Amount Per


Components
Serving












Telomere Maintenance Complex




Purslane extract (aerial parts)
5 
mg


Turmeric rhizome extract (95% curcuminoids)
25 
mg


Quercetin dihydrate
15 
mg


Cayenne pepper fruit
10 
mg


Vanadium (as vanadyl sulfate)
25 
mcg


Fenugreek seed
25 
mg


Astragalus root extract
10 
mg


Omega fatty acid complex including linoleic acid (10.6%), 
200 
mg


alpha-linolenic acid (1.3%), oleic acid (1.6%), 




borage seed oil (10% gamma-linolenic acid), 




evening primrose oil (4.8% GLA), fish body oil




(4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid)




Calorie Restriction Mimetics and Gene Expression Complex




Trans-resveratrol (from Polygonum cuspidatum root extract)
2 
mg


Pterostilbene (99%)
2 
mg


Fisetin 50% (Buxus microphlla Sieb (stem and leaf))
2 
mg


Alpha lipoic acid
10 
mg


Coenzyme Q-10
5
mg


Betaine HCl
4 
mg


Sulfur (from methylsulfonylmethane)
1.25 
mg


L-Carnitine tartrate
10 
mg


L-Carnitine HCL
5 
mg


Free Radical Scavenger Complex




Green tea leaf extract (40% catechin and polyphenols)
50 
mg


Anthocyanins (from bilberry fruit and grape skin extracts)
5 
mg


Ginkgo biloba leaf extract (24% ginkgo flavonglycosides, 6%
50 
mg


sesquiterpene lactones)




Green barley grass (aerial parts)
25 
mg


DNA Repair Complex




Water extract of uncaria tomentosa 
125 
mg


(containing carboxy alkyl esters)




N-acetyl-cysteine
12.5 
mg


Inositol hexaphosphate
2 
mg


Stem Cell Maintenance Complex




Chlorella algae
25 
mg


Spirulina algae
50 
mg


Klamath blue-green algae
75 
mg


Fuxoxanthin seaweed (whole plant)
25 
mg


Nori seaweed extract
2 
mg


Cell Regulation Complex




Gotu kola leaf
10 
mg


Phosphatidyl choline (from soy lecithin)
25 
mg


DMAE bitartrate
25 
mg


Cordyceps sinensis mushroom extract (1% cordyceptic acid)
12.5 
mg


Royal jelly 3X (5% 10-HDA)
10 
mg


L-Glutamine
50 
mg


Taurine
25 
mg


L-Phenylalanine
25 
mg


L-Tyrosine
25 
mg


Guarana seed extract (20% caffeine)
40 
mg


Amylase
600 
units


Neutral protease
150 
units


Cellulase
5 
units


Lactase
100 
units


Lipase
25 
units


Vitamins




Vitamin A (as retinyl palmitate and 85% as beta-carotene)
1,800 
IU


Vitamin C (as ascorbyl palmitate and ascorbic acid)
100 
mg


Vitamin D (as cholecalciferol)
40 
IU


Vitamin E (as d-alpha tocopheryl succinate and from 
50 
IU


mixed natural tocopherols)




Vitamin K (as phytonadione)
75 
mcg


Thiamin (as thiamin HCl)
5 
mg


Riboflavin (as riboflavin and riboflavin-5-phosphate)
4 
mg


Niacin (as niacinamide and niacin)
70 
mg


Vitamin B6 (as pyridoxine HCl and pyridoxal 5-phosphate)
12 
mg


Folate (as folic acid)
50 
mcg


Vitamin B12 (as cyanocobalamin)
80 
mcg


Biotin
50 
mcg


Pantothenic acid (as D-calcium pantothenate)
12 
mg


Minerals




Iodine (as potassium iodide and from kelp)
30 
mcg


Calcium (as calcium carbonate and citrate)
300 
mg


Zinc (as zinc glycinate)
2 
mg


Selenium (as selenomethionine)
30 
mcg


Copper (as copper lysinate)
0.2
mg


Manganese (as manganese gluconate)
0.2 
mg


Chromium (as chromium polynicotinate) 
50 
mcg


Molybdenum (as sodium molybdate)
8 
mg





Other ingredients: Microcrystalline cellulose, croscarmellose sodium, stearic acid, calcium silicate, magnesium stearate, silica and film coat ingredients (hypromellose, hydroxypropyl cellulose, and polyethylene glycol).






Example 2
A PM dietary supplement composition shown in Table 3 below was prepared, with the processes known in the art. The amount per serving described was provided in two capsules.







TABLE 4







Example PM Dietary Supplement Composition









Amount Per


Components
Serving












Telomere Maintenance Complex




Purslane extract (aerial parts)
5 
mg


Turmeric rhizome extract (95% curcuminoids)
25 
mg


Quercetin dihydrate
15 
mg


Cayenne pepper fruit
10 
mg


Vanadium (as vanadyl sulfate)
20
mcg


Fenugreek seed
20 
mg


Valerian root
30 
mg


Omega fatty acid complex including linoleic acid (10.6%), 
200 
mg


alpha-linolenic acid (1.3%), oleic acid (1.6%), 




borage seed oil (10% gamma-linolenic acid), 




evening primrose oil (4.8% GLA), fish body oil 




(4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid)




Calorie Restriction Mimetics and Gene Expression Complex




Resveratol (as Polygonum cuspidatum root extract)
2 
mg


Pterostilbene
2 
mg


Fisetin 50% (Buxus microphlla Sieb (stem and leaf))
2 
mg


Alpha-lipoic acid
10 
mg


Coenzyme Q10
3.5 
mg


Betaine (as betaine-HCl)
2.5 
mg


Sulfur (from methylsulfonylmethane)
1 
mg


L-Carnitine tartrate
10 
mg


Acetyl-L-carnitine
5 
mg


Free Radical Scavenger Complex




Cruciferous vegetable concentrate (broccoli, kale, 
40 
mg


radish) (2% glucosinolates)




Grape skin extract (37% total phenolics)
20 
mg


Tomato lycopene extract (20% lycopene)
2
mg


Rosemary 4:1 extract (aerial parts)
3.25 
mg


Pycnogenol (pine bark extract)
1.65 
mg


Lutein (from marigold flower extract)
0.8 
mg


Green barley grass
10 
mg


DNA Repair Complex




Water extract of uncaria tomentosa (containing carboxy 
125 
mg


alkyl esters)




Inositol hexaphosphate
2 
mg


N-acetyl cysteine
8 
mg


Melatonin
0.5 
mg


Stem Cell Maintenance Complex




Chlorella algae
25 
mg


Spirulina algae
15 
mg


Klamath blue green algae
45 
mg


Fucoxanthin seaweed (whole plant)
25 
mg


Brown seaweed extract
5 
mg


Cell Regulation Complex




Phosphatidylcholine (from soy lecithin)
20 
mg


Cordyceps sinensis mushroom extract (1% cordycepic acid)
8.25 
mg


Royal jelly 3x (5% 10-HDA)
9 
mg


Inositol
50 
mg


L-Glutamine
250 
mg


L-Arginine (as L-arginine HCl)
160 
mg


L-Ornithine (as L-ornithine HCl)
120 
mg


Taurine
16 
mg


L-Tyrosine
20 
mg


Probiotic blend including Lactobacillus acidophilus, 
50 
mil-


Lactobacillus plantarum, Bifidobacterium bifidum

lion


and Lactobacillus casei

CFU


Amylase
400 
units


Neutral protease
100 
units


Lactase
65
units


Lipase
16 
units


Vitamins




Vitamin A (as retinyl palmitate and 85% from natural 
1,400 
IU


mixed carotenoids)




Vitamin C (as ascorbic acid and ascorbyl palmitate)
200 
mg


Vitamin D (as cholecalciferol)
30 
IU


Vitamin E (as d-alpha-tocopheryl succinate and from 
40 
IU


mixed natural tocopherols)




Vitamin K (as phytonadione)
75
mcg


Thiamin (as thiamin HCl)
2.5 
mg


Riboflavin (as riboflavin and riboflavin-5-phosphate)
5 
mg


Niacin (as niacinamide and niacin)
70 
mg


Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
7.5 
mg


Folate (as folic acid)
80 
mcg


Vitamin B12 (as cyanocobalamin)
120 
mcg


Biotin
40 
mcg


Pantothenic acid (as D-calcium pantothenate)
20 
mg


Minerals




Iodine (as potassium iodide and from kelp)
12 
mcg


Magnesium (as magnesium oxide and glycinate)
132.5 
mg


Zinc (as zinc glycinate)
1.5 
mg


Selenium (as selenomethionine)
24 
mcg


Copper (as copper lysinate)
0.1 
mg


Manganese (as manganese gluconate)
0.1 
mg


Chromium (as chromium polynicotinate)
40 
mcg


Molybdenum (as sodium molybdate)
8 
mcg





Other ingredients: Microcrystalline cellulose, croscarmellose sodium, stearic acid, calcium silicate, magnesium stearate, silica and film coat ingredients (hypromellose, hydroxypropyl cellulose, and polyethylene glycol).






All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety.
While the invention has been disclosed in connection with certain preferred embodiments, this should not be taken as a limitation to all of the provided details. Modifications and variations of the described embodiments may be made without departing from the spirit and scope of the invention, and other embodiments should be understood to be encompassed in the present disclosure as would be understood by those of ordinary skill in the art.

## Claims

1. A dietary supplement system comprising:
(i) a first dietary supplement composition for oral administration by an individual in the morning, said first composition comprising:
(a) a telomere maintenance complex comprising:
Purslane extract (aerial parts), 4-6 mg; Turmeric rhizome extract (95% curcuminoids), 20-30 mg; Quercetin dehydrate, 12-18 mg; Cayenne pepper fruit, 8-12 mg; Vanadium (as vanadyl sulfate), 20-30 mcg; Fenugreek seed, 20-30 mg; Astragalus root extract, 8-12 mg; and Omega fatty acid complex, 160-240 mg, including linoleic acid (10.6%), alpha-linolenic acid (1.3%), oleic acid (1.6%), borage seed oil (10% gamma-linolenic acid (GLA)), evening primrose oil (4.8% GLA); and fish body oil (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid);
(b) a calorie restriction mimetics and gene expression complex comprising:
Trans-resveratrol (from Polygonum cuspidatum root extract), 1.6-2.4 mg; Pterostilbene (99%), 1.6-2.4 mg; Fisetin 50% (Buxus microphylla Sieb (stem and leaf)), 1.6-2.4 mg; Alpha lipoic acid, 8-12 mg; Coenzyme Q-10, 4-6 mg; Betaine HCl, 3.2-4.8 mg; Sulfur (from methylsulfonylmethane), 1-1.5 mg; L-Carnitine tartrate, 8-12 mg; and L-Carnitine HCl, 4-6 mg;
(c) a free radical scavenger complex comprising:
Green tea leaf extract (40% catechin and polyphenols), 40-60 mg; Anthocyanins (from bilberry fruit and grape skin extracts), 4-6 mg; Ginkgo biloba leaf extract (24% ginkgo flavonglycosides, 6% sesquiterpene lactones), 40-60 mg; and Green barley grass (aerial parts), 20-30 mg;
(d) a DNA repair complex comprising:
Water extract of Uncaria tomentosa (containing carboxy alkyl esters), 100-150 mg; N-acetyl-cysteine, 10-15 mg; and Inositol hexaphosphate, 1.6-2.4 mg;
(e) a stem cell maintenance complex comprising:
Chlorella algae, 20-30 mg; Spirulina algae, 40-60 mg; Klamath blue-green algae, 60-90 mg; fucoxanthin-containing seaweed (whole plant), 20-30 mg; and Nori seaweed extract, 1.6-2.4 mg;
(f) a cell regulation complex comprising:
Gotu kola leaf, 8-12 mg; Phosphatidyl choline (from soy lecithin), 20-30 mg; dimethylaminoethanol (DMAE) bitartrate, 20-30 mg; Cordyceps sinensis mushroom extract (1% cordyceptic acid), 10-15 mg; Royal jelly 3× (5% 10-hydroxy-2-decenoic acid), 8-12 mg; L-Glutamine, 40-60 mg; Taurine, 20-30 mg; L-Phenylalanine, 20-30 mg; L-Tyrosine, 20-30 mg; Guarana seed extract (20% caffeine), 32-48 mg; Amylase, 480-720 units; Neutral protease, 120-180 units; Cellulase, 4-6 units; Lactase, 80-120 units; and Lipase, 2.6-3.9 units;
(g) a group of vitamins comprising:
Vitamin A (as retinyl palmitate and 85% as beta-carotene), 1,440-2,160 IU; Vitamin C (as ascorbyl palmitate and ascorbic acid), 80-120 mg; Vitamin D (as cholecalciferol), 32-48 IU; Vitamin E (as d-alpha tocopheryl succinate and from mixed natural tocopherols), 40-60 IU; Vitamin K (as phytonadione), 60-90 mcg; Thiamin (as thiamin HCl), 4-6 mg; Riboflavin (as riboflavin and riboflavin-5-phosphate), 3.2-4.8 mg; Niacin (as niacinamide and niacin), 56-84 mg; Vitamin B6 (as pyridoxine HCl and pyridoxal 5-phosphate), 9.6-14.4 mg; Folate (as folic acid), 40-60 mcg; Vitamin B12 (as cyanocobalamin), 64-96 mcg; Biotin, 40-60 mcg; and Pantothenic acid (as D-calcium pantothenate), 9.6-14.4 mg; and
(h) a group of minerals comprising:
Iodine (as potassium iodide and from kelp), 24-36 mcg; Calcium (as calcium carbonate and citrate), 240-360 mg; Zinc (as zinc glycinate), 1.6-2.4 mg; Selenium (as selenomethionine), 24-36 mcg; Copper (as copper lysinate), 0.16-0.24 mg; Manganese (as manganese gluconate), 0.16-0.24 mg; Chromium (as chromium polynicotinate), 40-60 mcg; and Molybdenum (as sodium molybdate), 6.4-9.6 mg; and
(ii) a second dietary supplement composition for oral administration in the evening, said second composition comprising:
(a) a telomere maintenance complex comprising:
Purslane extract (aerial parts), 4-6 mg; Turmeric rhizome extract (95% curcuminoids), 20-30 mg; Quercetin dehydrate, 12-18 mg; Cayenne pepper fruit, 8-12 mg; Vanadium (as vanadyl sulfate), 16-24 mcg; Fenugreek seed, 16-24 mg; Valerian root extract, 24-36 mg; and Omega fatty acid complex, 160-240 mg, including linoleic acid (10.6%), alpha-linolenic acid (1.3%), oleic acid (1.6%), borage seed oil (10% gamma-linolenic acid (GLA)), evening primrose oil (4.8% GLA); and fish body oil (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid);
(b) a calorie restriction mimetics and gene expression complex comprising:
Resveratrol (as Polygonum cuspidatum root extract), 1.6-2.4 mg; Pterostilbene, 1.6-2.4 mg; Fisetin 50% (Buxus microphylla Sieb (stem and leaf)), 1.6-2.4 mg; Alpha-lipoic acid, 8-12 mg; Coenzyme Q10, 2.8-4.2 mg; Betaine (as betaine-HCl, 2-3 mg; Sulfur (from methylsulfonylmethane), 0.8-1.2 mg; L-Carnitine tartrate, 8-12 mg; and Acetyl-L-Carnitine HCl, 4-6 mg;
(c) a free radical scavenger complex comprising:
Cruciferous vegetable concentrate (broccoli, kale, radish) (2% glucosinolates), 32-48 mg; Grape skin extract (37% total phenolics), 16-24 mg; Tomato lycopene extract (20% lycopene), 1.6-2.4 mg; Rosemary extract (aerial parts), 2.6-3.9 mg; Pycnogenol (pine bark extract), 1.32-1.98 mg; Lutein (from marigold flower extract), 0.64-0.96 mg; and Green barley grass, 8-12 mg;
(d) a DNA repair complex comprising:
Water extract of Uncaria tomentosa (containing carboxy alkyl esters), 100-150 mg; Inositol hexaphosphate, 1.6-2.4 mg; N-acetyl cysteine, 6.4-9.6 mg; and Melatonin, 0.4-0.6 mg
(e) a stem cell maintenance complex comprising:
Chlorella algae, 20-30 mg; Spirulina algae, 12-18 mg; Klamath blue green algae, 36-54 mg; Fucoxanthin-containing seaweed (whole plant), 20-30 mg; and Brown seaweed extract, 4-6 mg;
(f) a cell regulation complex comprising:
Phosphatidylcholine (from soy lecithin), 16-24 mg; Cordyceps sinensis mushroom extract (1% cordycepic acid), 6.6-9.9 mg; Royal jelly 3× (5% 10-hydroxy-2-decenoic acid), 7.2-10.8 mg; Inositol, 40-60 mg; L-Glutamine, 200-300 mg; L-Arginine (as L-arginine HCl), 128-192 mg; L-Ornithine (as L-ornithine HCl), 96-144 mg; Taurine, 12.8-19.2 mg; L-Tyrosine, 16-24 mg; Probiotic blend including Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium bifidum and Lactobacillus casei, 40-60 million CFU; Amylase, 320-480 units; Neutral protease, 80-120 units; Lactase, 52-78 units; and Lipase, 12.8-19.2 units;
(g) a group of vitamins comprising:
Vitamin A (as retinyl palmitate and 85% from natural mixed carotenoids), 1,120-1,680 IU; Vitamin C (as ascorbic acid and ascorbyl palmitate), 160-240 mg; Vitamin D (as cholecalciferol), 24-36 IU; Vitamin E (as d-alpha-tocopheryl succinate and from mixed natural tocopherols), 32-48 IU; Vitamin K (as phytonadione), 60-90 mcg; Thiamin (as thiamin HCl), 2-3 mg; Riboflavin (as riboflavin and riboflavin-5-phosphate), 4-6 mg; Niacin (as niacinamide and niacin), 56-84 mg; Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate), 6-9 mg; Folate (as folic acid), 64-96 mcg; Vitamin B12 (as cyanocobalamin), 96-144 mcg; Biotin, 32-48 mcg; and Pantothenic acid (as D-calcium pantothenate), 16-24 mg; and
(h) a group of minerals comprising:
Iodine (as potassium iodide and from kelp), 9.6-14.4 mcg; Magnesium (as magnesium oxide and glycinate), 106-159 mg; Zinc (as zinc glycinate), 1.2-1.8 mg; Selenium (as selenomethionine), 19.2-28.8 mcg; Copper (as copper lysinate), 0.08-0.12 mg; Manganese (as manganese gluconate), 0.08-0.12 mg; Chromium (as chromium polynicotinate), 32-48 mcg; and Molybdenum (as sodium molybdate), 6.4-9.6 mcg, wherein each component is defined in an amount of per serving of each of said compositions.