1

United States Chemical Safety September 2012

Environmental Protection and Pollution Prevention

Agency (7510P)

Ammonium Bromide

Summary Document:

Registration Review: Initial Docket

September 2012
Docket Number: EPA-HQ-OPP-2012-0683 

www.regulations.gov 

Ammonium Bromide 

Summary Document 

Registration Review: Initial Docket 

September 2012 

Case# 5002 

Approved By: 

£r"• 

Duector, ~HarriAntimicrobials 

:Z:~ DIVISion 

Date: 

2 

.· 
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TABLE OF CONTENTS

Ammonium Bromide Registration Review Team .......................................................................... 4

I. Preliminary Work Plan -- Ammonium Bromide ......................................................................... 5

II. Fact Sheet ................................................................................................................................. 12

III. Summary of Anticipated Data Requirements – Ammonium Bromide................................... 16

IV. Appendix A: Use Patterns – Ammonium bromide................................................................ 17

________________________________________

Please Note

This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's 

current position based on the following documents:

1. Product Chemistry, Environmental Fate, and Ecological Effects Scoping Document in 

Support of Registration Review of Ammonium Bromide. September 24, 2012

2. Ammonium Bromide: Human Health Registration Review Scoping Document. 

September 19, 2012

Additional supporting documents for the Ammonium Bromide Case may be found in the 

registration review docket EPA-HQ-OPP-2012-0683 located on the internet at

www.regulations.gov.
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Ammonium Bromide Registration Review Team

Human Health & Environmental Effects

Timothy Dole

Jenny Tao

William Hazel

Srinivas Gowda

Najm Shamim

William Erickson

Risk Management

Rebecca von dem Hagen

Lance Wormell

Office of General Counsel

Philip Ross
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I. Preliminary Work Plan -- Ammonium Bromide

Introduction:

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review program. All 

pesticides distributed or sold in the United States generally must be registered by the U.S. 

Environmental Protection Agency (USEPA, EPA, or the Agency) based on scientific data 

showing that they will not cause unreasonable risks to human health or the environment when 

used as directed on product labeling. The registration review program is intended to make sure 

that, as the ability to assess risk evolves and as policies and practices change, all registered 

pesticides continue to meet the statutory standard of no unreasonable adverse effects to human 

health or the environment. Changes in science, public policy, and pesticide use practices will 

occur over time. Through the registration review program, the Agency periodically reevaluates 

pesticides to make sure that as change occurs, products in the marketplace can be used safely. 

Information on this program is provided at http://www.epa.gov/oppsrrd1/registration_review/.

The Agency is implementing the registration review program pursuant to Section 3(g) of the 

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered 

pesticide every 15 years to determine whether it continues to meet the FIFRA standard for 

registration. The Agency will consider benefits information and data as required by FIFRA. The 

public phase of registration review begins when the initial docket is opened for each case. The 

docket is the Agency’s opportunity to state what it knows about the pesticide and what additional 

risk analyses and data or information it believes are needed to make a registration review 

decision. After reviewing and responding to comments and data received in the docket during 

this initial comment period, the Agency will develop and commit to a final work plan and 

schedule for the Ammonium Bromide Case.

The first product containing ammonium bromide (PC Code 000352, Case #5002) as an active 

ingredient was registered in the United States in 1999 for use in recirculating cooling water 

systems and pulp and papermills. Currently, there are five products containing ammonium 

bromide as the active ingredient registered with the EPA. Ammonium bromide is an algicide, 

bactericide, microbicide and slimicide registered for use in industrial process and water systems 

such as recirculating cooling towers, pulp and papermills and wastewater treatment systems.

Paper and paperboard treated with ammonium bromide are approved for food contact use. The 

registered ammonium bromide products may be mixed on-site with a substance such as sodium 

hypochlorite or chlorine gas to form a monochloramine solution. The monochloramine solution 

is the active biocide in the pulp, papermill and other industrial water systems. Ammonium 

bromide is not registered for use in drinking water systems. Products registered as ammonia (PC 

Code 005302, Case #7440) and ammonium sulfate (PC Code 005601, Case # 5073) are also used 

in conjuction with an oxidizing agent to form a monochloromine solution; however, the Agency 

is evaluating ammonia and ammonium sulfate under separate registration review cases because 

the chemical reaction of ammonium bromide when mixed on-site as noted above results in the 

formation of hypobromous acid in addition to monochloramine.

EPA did not complete a reregistration eligibility decision (RED) for ammonium bromide because 

the first pesticide product containing ammonium bromide was registered after November 1, 

1984.
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Documents associated with the registration review of ammonium bromide can be viewed at 

www.regulations.gov in docket EPA-HQ-OPP-2012-0683. Documents associated with the 

registration review of the Ammonia and Ammonium Sulfate Cases can be viewed at 

www.regulations.gov in docket EPA-HQ-OPP-2012-0684. Below is a summary of the issues 

relevant to this registration review case.

Anticipated Risk Assessment and Data Needs:

The Agency does not anticipate the need to conduct an ecological risk assessment. The Agency 

anticipates the need to conduct a human health risk assessment. The Agency anticipates needing 

additional data for use in conducting the registration review for ammonium bromide.

Ecological Risk:

• A quantiative ecological risk assessment has not been performed for ammonium bromide

due to the low likelihood of exposure. 

• Based on the low likelihood of exposure, the Agency intends to conclude that the 

registered uses of ammonium bromide will have 'no effect' (NE) on endangered or 

threatened terrestrial or aquatic species, or their designated critical habitats, as listed by 

the U.S. Fish and Wildlife Service (USFWS) and the National Oceanic and Atmospheric 

Administration's (NOAA) National Marine Fisheries Service (NMFS). EPA anticipates 

conducting no further analysis of potential risks to endangered or threatened species 

unless public comment provides data or information that would otherwise inform the 

Agency's determination.

• The Agency does not anticipate the need to require additional ecological or 

environmental fate data for this registration review case at this time.

• For more information, please refer to Product Chemistry, Environmental Fate, and 

Ecological Effects Scoping Document in Support of Registration Review of Ammonium 

Bromide, located in the docket.

Human Health Risk: 

• A human health risk assessment has not been performed for ammonium bromide.

• The Agency anticipates the need to conduct an occupational exposure risk assessment for 

the registration review of ammonium bromide. If labels were amended to require that a 

closed system be used for the mixing of ammonium bromide and sodium hypochlorite or 

another chlorine source, then the Agency anticipates that a risk assessment will no longer 

be needed because human exposure will not occur.

• The Agency anticipates the need to require the following additional human health data 

for use in the registration review of ammonium bromide.

875.3465 – 28-day inhalation toxicity

875.1400 -- Inhalation indoor exposure
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875.1600 -- Application exposure data reporting and calculations

• For more information, please refer to Ammonium Bromide: Human Health Registration 

Review Scoping Document, located in the docket.

Product Chemistry:

• The Agency anticipates the need to require the following additional product chemistry 

data for use in the registration review of ammonium bromide.

 830.7520 – Particle size

• For more information, please refer to Product Chemistry, Environmental Fate, and 

Ecological Effects Scoping Document in Support of Registration Review of Ammonium 

Bromide and Ammonium Bromide: Human Health Registration Review Scoping 

Document, located in the docket.

Endocrine Disruptor Screening Program

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse 

outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and 

chronic toxicity, including assessments of carcinogenicity, neurotoxicity, developmental, 

reproductive, and general or systemic toxicity. These studies include endpoints which may be 

susceptible to endocrine influence, including effects on endocrine target organ histopathology, 

organ weights, estrus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, 

and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and 

chronic studies that assess growth, developmental and reproductive effects in different 

taxonomic groups. A human health risk assessment identifying the most sensitive endpoints has 

not been conducted for ammonium bromide. However, as required by FFDCA section 408(p), 

ammonium bromide is subject to the endocrine screening part of the Endocrine Disruptor 

Screening Program (EDSP). 

EPA has developed the EDSP to determine whether certain substances (including pesticide 

active and other ingredients) may have an effect in humans or wildlife similar to an effect 

produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator 

may designate.” The EDSP employs a two-tiered approach to making the statutorily required 

determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a 

chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal 

systems. Chemicals that go through Tier 1 screening and are found to have the potential to 

interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA 

will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 

testing is designed to identify any adverse endocrine-related effects caused by the substance, and 

establish a dose-response relationship between the dose and the E, A, or T effect.

Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between October 

2009 and February 2010, EPA issued test orders/data call-ins for the first group of 67 chemicals, 

which contains 58 pesticide active ingredients and 9 inert ingredients. Ammonium bromide is not 
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among the group of 58 pesticide active ingredients on the initial list to be screened under the 

EDSP. Accordingly, as part of registration review, EPA will issue future EDSP orders/data callins, requiring the submission of EDSP screening assays for ammonium bromide. For further 

information on the status of the EDSP, the policies and procedures, the list of 67 chemicals, 

future lists, the test guidelines and the Tier 1 screening battery, please visit our website: 

http://www.epa.gov/endo/.

Timeline

EPA has created the following estimated timeline for the completion of the ammonium bromide

registration review:

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket

Open Docket and 60-Day Public Comment Period for PWP September 2012

Close Public Comment Period for Docket November 2012

Phase 2: Case Development

Develop Final Work Plan (FWP) March 2013

Issue DCI March 2014

Data Submission March 2015

Open 30-Day Public Comment Period for Preliminary Risk 

Assessments 

September 2016

Close Public Comment Period for Preliminary Risk Assessments October 2016

Phase 3: Registration Review Decision

Open 60-Day Public Comment Period for Proposed Reg. Review 

Decision 

March 2017

Close Public Comment Period for Proposed Reg. Review Decision May 2017

Final Decision and Begin Post-Decision Follow-up 2017

Total (years) 5

Guidance for Commenters:

The public is invited to comment on EPA’s Preliminary Work Plan and rationale. The Agency 

will carefully consider all comments as well as any additional information or data provided in a 

timely manner prior to issuing a final work plan for the ammonium bromide registration review 

case.

Trade Irritants:

Through the registration review process, the Agency intends to solicit information on trade 

irritants and, to the extent feasible, take steps toward facilitating irritant resolution. Growers and 

other stakeholders are asked to comment on any trade irritant issues resulting from lack of 
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Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key 

export markets, providing as much specificity as possible regarding the nature of the concern. 

Water Quality:

Ammonium bromide is not identified as a cause of impairment for any water bodies listed as 

impaired under section 303(d) of the Clean Water Act, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=88

5. In addition, no Total Maximum Daily Loads (TMDL) have been developed for ammonium 

bromide, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_group_id

=885&p_pollutant_group_name=PESTICIDES.

More information on impaired water bodies and TMDLs can be found at 

http://www.epa.gov/owow/tmdl/. The Agency invites submission of water quality data for this 

pesticide. To the extent possible, data should conform to the quality standards in Appendix A of 

the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water 

Quality Data in OPP’s Registration Review Risk Assessment and Management Process (see: 

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm), in order to ensure the 

data can be used quantitatively or qualitatively in pesticide risk assessments.

Environmental Justice:

EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all 

people, regardless of race, color, national origin, or income, in the development, implementation, 

and enforcement of environmental laws, regulations, and policies. To help address potential 

environmental justice issues, the Agency seeks information on any groups or segments of the 

population who, as a result of their location, cultural practices, or other factors, may have 

atypical, unusually high exposure to ammonium bromide compared to the general population. 

Please comment if you are aware of any sub-populations that may have atypical, unusually high 

exposure compared to the general population.

Structure Activity Relationships: 

EPA must rely upon information of appropriate quality and reliability for each decision made by 

the Agency. In the Office of Pesticide Programs (OPP), the evaluation process for a pesticide 

chemical traditionally begins with the applicant’s submission of a set of studies conducted with 

the specific pesticide chemical of interest. The use of the results of such testing (measured data) 

is a logical, scientifically rigorous process that identifies the physical, chemical, and 

environmental fate properties of the pesticide, as well as the dose and endpoints at which an 

adverse effect can occur in various animal species. 

Today, there is significant interest in alternative techniques, i.e., techniques other than data 

generation that could significantly inform the Agency’s decision-making process. Recently, OPP 

has made increasing use of structure activity relationship (SAR) as part of its regulatory 

decision-making process. In the SAR process, a chemical's molecular structure is compared to 
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that of other chemicals for which data are available. These structural similarities are then used to 

make predictive judgments about a chemical’s physical, chemical, and biological properties. 

Thus, the chemical’s physical, chemical, and biological properties are a function of (or directly 

related to) the chemical’s molecular structure. Quantitative SAR is referred to as QSAR. To 

develop a QSAR, a selected set of measured data on a single physical, chemical, or biological 

property is used to derive a model (an equation) to predict the value of that property. 

Since SAR assessments and QSAR modeling are another set of tools that are available to Agency 

scientists, OPP has begun a process shift that envisions shifting from the current study-by-study 

approach to an approach in which the use of predicted data, generated using validated models, is 

considered along with information from open literature and studies specifically generated under 

Part 161 requirements. All relevant information would be considered as part of a weight-of-theevidence evaluation. 

At this time, EPA believes that for certain endpoints, especially physical/chemical and fate 

properties, that SAR and QSAR might be effectively utilized to fulfill these data requirements 

for many antimicrobial pesticide chemicals. When considering biological properties, at this time, 

EPA believes that SAR and QSAR can be most effectively utilized in the evaluation of 

chemicals that exhibit lower toxicity for human health and/or ecotoxicity parameters. This is 

appropriate because the risk assessment for lower toxicity chemicals can be stream-lined, i.e., a 

screening-level assessment procedure rather than multiple tiers of assessments with progressively 

more data requirements.

If stakeholders believe that submission of predicted data can fulfill one of the data needs for the 

ammonium bromide case, then the Agency invites submission of this information. The submitter 

would be expected to supply a rationale describing the utility of the information and provide 

documentation on the scientific validity of the information. The determination that the predicted 

data fulfills the data requirement would be at the sole discretion of the Agency. Pre-submission 

consultation with the Agency is encouraged.

Additional Information:

Stakeholders are also specifically asked to provide available information and data that will assist 

the Agency in refining its risk assessments, including any species-specific ecological effects 

determinations. The Agency is interested in receiving the following information:

1. Confirmation on the following label information:

a. Sites of application

b. Formulations

c. Application methods and equipment

d. Maximum application rates

e. Frequency of application, application intervals and maximum number of 

applications

f. Geographic limitations on use

2. Use or potential use distribution

3. Use history

4. Usage/use information for non-agricultural uses (e.g., materials preservation)
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5. Typical application interval

6. State or local use restrictions

7. Ecological incidents (non-target plant damage and avian, fish, reptilian, amphibian 

and mammalian mortalities) not already reported to the Agency

8. Monitoring data

Next Steps:

After the 60-day comment period closes in November 2012, the Agency will review and respond 

to any comments received in a timely manner, and then issue a Final Work Plan for the 

ammonium bromide Case. 
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II. Fact Sheet

Background Information:

• Active Ingredient: ammonium bromide

• Case number: 5002

• PC Code: 000352

• CAS number: 12124-97-9

• Technical registrants: ICL-IP America, Inc.

• First approved for use in a registered product: 1999

• There are no tolerances or exemptions from a tolerance for ammonium bromide.

• Antimicrobials Division Chemical Review Manager (CRM): Rebecca von dem Hagen, 

vondem-hagen.rebecca@epa.gov

• Antimicrobials Division Product Manager (PM): Monisha Harris, 

harris.monisha@epa.gov

• Chemical Structure: 

Use & Usage Information:

• Ammonium bromide is an algicide, bactericide, microbicide and slimicide registered for 

use in industrial process and water systems such as recirculating cooling towers, pulp and 

papermills and wastewater treatment systems. Paper and paperboard are approved for 

food contact use.

• The registered ammonium bromide products may be mixed on-site by authorized 

personnel with a substance such as sodium hypochlorite or chlorine gas to form a 

monochloramine solution. The monochloramine solution is the active biocide in the pulp, 

papermill and other industrial water systems. 

Recent/Pending Regulatory Actions:

• There are no recent or pending regulatory actions for ammonium bromide.

Ecological Risk Assessment Status:

Please refer to Product Chemistry, Environmental Fate, and Ecological Effects Scoping 

Document in Support of Registration Review of Ammonium Bromide, located in the docket, for a 

detailed discussion of the ecological risk assessments.

• A quantitative ecological risk assessment has not been conducted on ammonium bromide 

due to the low likelihood of exposure.
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Human Health Risk Assessment Status:

The following are key findings of the recent human health risk assessments for Ammonium 

bromide. Please refer to Ammonium Bromide: Human Health Registration Review Scoping 

Document, located in the docket, for a detailed discussion of the human health risk assessment.

Hazard Characterization:

• Ammonium bromide is of low acute oral, dermal, and inhalation toxicity (Toxicity 

Category III). Ammonium bromide is irritating to the eyes (Toxicity Category II) but not 

to the skin (Toxicity Category IV). Ammonium bromide is not a dermal sensitizer.

Dietary (Food and Water):

• The Agency believes that the only potentially toxic compound resulting from ammonium 

bromide use in the water system is monochloramine. No residues of potential 

toxicological concern are expected to survive the paper or paperboard manufacturing 

processes. Any monochloramine not consumed in the water system is expected to 

degrade under the high temperature conditions of the paper drying process (110 °C); 

therefore, dietary (food) exposure is not expected.

• A drinking water assessment has not been conducted due to the low likelihood of 

exposure. EPA’s Office of Water has established a maximum residual disinfectant level 

(MRDL) of 4.0 ppm and water utilities are required to maintain total chloramines at or 

below this MRDL. Given this limit, the fact that the maximum application rate is 10 ppm 

(for paper mills), and the fact that most of the monochloramine will be consumed during 

the treatment process, the Agency does not anticipate drinking water exposures to 

monochloramine. Ammonium bromide is not registered for use in drinking water 

systems.

Residential:

• A residential assessment has not been conducted for the ammonium bromide products 

because residential exposure is not expected from the registered use patterns.

Aggregate:

• In examining aggregate exposure, EPA takes into account the available and reliable 

information concerning exposures to pesticide residues in food and drinking water, as 

well as non-occupational pesticide exposures. An aggregate risk assessment has not been 

deemed necessary for ammonium bromide due to the lack of residential and dietary 

exposure.

Occupational:

• The most recent occupational exposure assessment on ammonium bromide was 

conducted in 2002 in support of the registration of ammonium bromide as a liquid 

applied in a closed system. No risks of concern were identified. 
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• An occupational risk assessment has not been conducted for the solid ammonium 

bromide products.

Cumulative:

• EPA does not have, at this time, available data to determine whether ammonium bromide

has a common mechanism of toxicity with other substances or how to include this 

pesticide in a cumulative risk assessment. For the purposes of this Registration Review, 

EPA has assumed that ammonium bromide does not have a common mechanism of 

toxicity with other substances when used as an antimicrobial as registered.

Incidents:

Ecological:

• No ammonium bromide ecological incidents have been reported in the OPP incident 

database.

Human Health:

• No ammonium bromide human poisoning incidents have been reported in the OPP 

incident database.

Tolerances and International Harmonization:

• There are no tolerances or exemptions from a tolerance established for ammonium 

bromide.

Data Call-In Status:

• No data call-ins have been issued for the registered ammonium bromide products.

Labels:

Registered products, including EPA registration numbers are provided in Table 1 below. For 

future reference, during registration review a list of product registration numbers will be included 

in the docket. Product registration labels may be obtained from the Pesticide Product Label 

System (PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home.

Table 1. Registered Products – Ammonium Bromide

Registration # Registration Name Company Name Formulation Type % of Active 

Ingredient

8622-58 Fuzzicide-Comp ICL-IP America, Inc. Soluble Concentrate 99

8622-59 Ammonium Bromide-Comp ICL-IP America, Inc. Technical Chemical 99

8622-64 Fuzzicide Solution ICL-IP America, Inc. Ready-to-Use 35
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Registration # Registration Name Company Name Formulation Type % of Active 

Ingredient

Solution

8622-75 Ammonium Bromide-SP ICL-IP America, Inc. Technical Chemical 99

8622-76 Fuzzicide-SP (Ammonium 

Bromide) ICL-IP America, Inc. Soluble Concentrate/Solid 99
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III. Summary of Anticipated Data Requirements – Ammonium Bromide

The table below summarizes anticipated data needs for the Ammonium Bromide Case in Section 

I of this document (Preliminary Work Plan), Product Chemistry, Environmental Fate, and 

Ecological Effects Scoping Document in Support of Registration Review of Ammonium Bromide, 

and Ammonium Bromide: Human Health Registration Review Scoping Document.

Table 2. Summary of Anticipated Data Requirements – Ammonium Bromide

Guideline

Number Anticipated Data Requirement Test Material

Estimated Timeframe 

(Measured in months 

from DCI Receipt)

870.3465 28-day inhalation toxicity1,2 TGAI 12

875.1400 Inhalation indoor exposure2 TGAI/MUP 12

875.1600 Application exposure data reporting 

and calculations2 TGAI/MUP 12

830.7520 Particle size2 EUP 12

 1 Although Guideline 870.3465 is for a 90-day inhalation toxicity test, the Agency would consider accepting a 28-

day inhalation toxicity study.

2 If labels are amended to require mixing of ammonium bromide and sodium hypochlorite or another chlorine source

in a closed system, registrants may request that EPA waive the requirement for Guidelines 870.3465, 875.1400, 

875.1600 and 830.7520.
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IV. Appendix A: Use Patterns – Ammonium bromide

EPA 

Reg 

Number 

used for 

Max. 

Appl. 

Rate Formulation

% Active 

Ingredient 

in End Use 

Formulation

Use 

Category

Use Site Treatment 

Site/surfaces

Method of 

Application

Max 

Application/Use 

Rate

Use Limitations

8622-58

Soluble 

Concentrate 99

Industrial 

processes 

and water 

systems

Recirculating cooling 

systems

Industrial 

cooling towers, 

evaporative 

condensers, 

heat exchange 

water towers, 

influent systems 

such as flow 

through filters, 

industrial water 

scrubbing 

systems, 

brewery 

pasteurizers, 

sewage systems 

(septic tanks, 

leach fields, 

tank lines, 

sewers, lagoons,

and sewage 

effluent water), 

industrial airwashing 

systems 

equipped with a 

mist eliminator.

Metered 0.3-5.0 ppm of 

residual biocide 

expressed as total 

chlorine. 

Recommended 

dosage may be 

achieved by 

mixing 1.5 pounds 

of chlorine gas 

(99.9%) or 1.3 

gallons NaOCI 

(12.5%) with each 

aqueous solution 

containing 2.2 

pounds of end use 

product.

End use product 

is to be used only 

in conjunction 

with: 1) an 

oxidant such as 

sodium 

hypochlorite 

(12.5%) or 

chlorine gas 

(99.9%) to and 

2) the approved 

feeder/delivery 

system.
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8622-58

Soluble 

Concentrate 99

Industrial 

processes 

and water 

systems

Pulp and paper mills Pulp and paper 

mill fresh and 

sea water 

influent 

systems, and 

associated 

cooling water 

systems and 

wastewater 

treatment 

systems, pulp, 

paper and paper 

board mills 

systems, 

nonpotable 

water systems, 

starch slurries, 

and other 

process water 

that may 

contact food.

Metered 0.3-10.0 ppm of 

residual biocide 

expressed as total 

chlorine. 

Recommended 

dosage may be 

achieved by 

mixing 1.5 pounds 

of chlorine gas 

(99.9%) or 1.3 

gallons NaOCI 

(12.5%) with each 

aqueous solution 

containing 2.2 

pounds of end use 

product.

End use product 

is to be used only 

in conjunction 

with: 1) an 

oxidant such as 

sodium 

hypochlorite 

(12.5%) or 

chlorine gas 

(99.9%) to and 

2) the approved 

feeder/delivery 

system. Do not 

exceed 0.5 

pounds per 2205 

pounds of dry 

weight fiber in 

paper and 

paperboard 

components that 

contact food.

8622-59

Technical 

Chemical 99

This product is for 

FORMULATING 

USE ONLY into 

EPA registered 

antimicrobials for the 

following use: 

recirculating cool 

water systems, pulp 

and papermills.
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8622-64

Ready-to-Use 

Solution 35

Industrial 

processes 

and water 

systems

Recirculating cooling 

systems

Industrial 

cooling towers, 

evaporative 

condensers, 

heat exchange 

water towers, 

influent systems 

such as flow 

through filters, 

industrial water 

scrubbing 

systems, 

brewery 

pasteurizers, 

sewage systems 

(septic tanks, 

leach fields, 

tank lines, 

sewers, lagoons,

and sewage 

effluent water), 

industrial airwashing 

systems 

equipped with a 

mist eliminator.

Metered 0.3-5.0 ppm of 

residual biocide 

expressed as total 

chlorine. 0.54 

gallons of Sodium 

Hypochlorite 

(12.5%) with 0.22 

gallons of end use 

product

End use product 

is to be used only 

in conjunction 

with: 1) an 

oxidant such as 

sodium 

hypochlorite 

(12.5%) and 2) 

the approved 

feeder/delivery 

system.

8622-64

Ready-to-Use 

Solution 35

Industrial 

processes 

and water 

systems

Pulp and paper mills Pulp and paper 

mill fresh and 

sea water 

influent 

systems, and 

associated 

cooling water 

systems and 

wastewater 

treatment 

systems, pulp, 

paper and paper 

board mills 

systems, 

Metered 0.3-10.0 ppm of 

residual biocide 

expressed as total 

chlorine. 0.54 

gallons of Sodium 

Hypochlorite 

(12.5%) with 0.22 

gallons of end use 

product

End use product 

is to be used only 

in conjunction 

with: 1) an 

oxidant such as 

sodium 

hypochlorite 

(12.5%) and 2) 

the approved 

feeder/delivery 

system. Do not 

exceed 0.5 

pounds per 2205 

pounds of dry 
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20

nonpotable 

water systems, 

starch slurries, 

and other 

process water 

that may 

contact food.

weight fiber in 

paper and 

paperboard 

components that 

contact food.

8622-75

Technical 

Chemical 99

This product is for 

FORMULATING 

USE ONLY into 

EPA registered 

antimicrobials for the 

following use: 

recirculating cool 

water systems, pulp 

and papermills.

8622-76

Soluble 

Concentrate/Solid 99

Industrial 

processes 

and water 

systems

Recirculating cooling 

systems

Industrial 

cooling towers, 

evaporative 

condensers, 

heat exchange 

water towers, 

influent systems 

such as flow 

through filters, 

industrial water 

scrubbing 

systems, 

brewery 

pasteurizers, 

sewage systems 

(septic tanks, 

leach fields, 

tank lines, 

sewers, lagoons, 

and sewage 

effluent water), 

Metered 0.3-5.0 ppm of 

residual biocide 

expressed as total 

chlorine. 

Recommended 

dosage may be 

achieved by 

mixing 1.5 pounds 

of chlorine gas 

(99.9%) or 1.3 

gallons NaOCI 

(12.5%) with each 

aqueous solution 

containing 2.2 

pounds of end use 

product.

End use product 

is to be used only 

in conjunction 

with: 1) an 

oxidant such as 

sodium 

hypochlorite 

(12.5%) or 

chlorine gas 

(99.9%) to and 

2) the approved 

feeder/delivery 

system.
Docket Number: EPA-HQ-OPP-2012-0683

www.regulations.gov

21

industrial airwashing 

systems 

equipped with a 

mist eliminator.

8622-76

Soluble 

Concentrate/Solid 99

Industrial 

processes 

and water 

systems

Pulp and paper mills Pulp and paper 

mill fresh and 

sea water 

influent 

systems, and 

associated 

cooling water 

systems and 

wastewater 

treatment 

systems, pulp, 

paper and paper 

board mills 

systems, 

nonpotable 

water systems, 

starch slurries, 

and other 

process water 

that may 

contact food.

Metered 0.3-10.0 ppm of 

residual biocide 

expressed as total 

chlorine. 

Recommended 

dosage may be 

achieved by 

mixing 1.5 pounds 

of chlorine gas 

(99.9%) or 1.3 

gallons NaOCI 

(12.5%) with each 

aqueous solution 

containing 2.2 

pounds of end use 

product.

End use product 

is to be used only 

in conjunction 

with: 1) an 

oxidant such as 

sodium 

hypochlorite 

(12.5%) or 

chlorine gas 

(99.9%) to and 

2) the approved 

feeder/delivery 

system. Do not 

exceed 0.5 

pounds per 2205 

pounds of dry 

weight fiber in 

paper and 

paperboard 

components that 

contact food.