Fw: Urgent Request for Information from your 2009 study Pradeep Rajan
to: Tricia Crabtree 12/17/2010 02:48 PM Show Details

-----Forwarded by Pradeep Rajan/RTP/USEPA/US on 12/17/2010 02:47PM -----

To: Rajan.Pradeep@epamail.epa.gov From: Rick Burnett <Rick.Burnett@hc-sc.gc.ca> Date: 09/13/2010 08:41AM Subject: Fw: Urgent Request for Information from your 2009 study

here they are, sorry for the delay, you will note that these numbers

our based on our main analysis file, subsets of the cohort are used for different runs depending on the available variables (ie missing values etc) ----- Forwarded by Rick Burnett/HC-SC/GC/CA on 2010-09-13 08:39 AM -

----

Yuanli Shi

<syuanli@uottawa.

ca> To 'Rick Burnett'

2010-08-30 04:50 <Rick.Burnett@hc-sc.gc.ca>

PM

cc Michelle Turner

<mturner@uottawa.ca>

Subject RE: FW: Fw: Urgent Request for Information from your 2009 study Page 1 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...OK, please find the attached files for ACS follow up to 2000....

Yuanli

-----Original Message----- From: Rick Burnett [ mailto:Rick.Burnett@hc

- sc.gc.ca ] Sent: Friday, August 27, 2010 2:11 PM To: Yuanli Shi Cc: Michelle Turner Subject: RE: FW: Fw: Urgent Request for Information from your 2009 study

Yuanli, they want the info based on the new HEI report and in Table 1 of the report it says we used 58 MSAs for the 1979-1983 PM2.5 with 351.338 subjects

so we need the number of deaths and number of subjects in these 58
MSAs with the number of deaths based on the 2000 followup, thanks

we also need the 2000 followup for the 116 MSAs for the PM2.5 1999- 2000 dataset

Yuanli Shi <syuanli@uottawa.

ca> To 'Rick Burnett' 2010-08-26 01:39 <Rick.Burnett@hc-sc.gc.ca>, PM Michelle Turner
<mturner@uottawa.ca>

cc Page 2 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...Subject RE: FW: Fw: Urgent Request for Information from your 2009 study

Hi Rick and Michelle, please see the attached excel files. There were 61 MSAs for the PM2.5 in 1979/83 (mean), and 116 MSAs for PM2.5 (mean) in 1999/2000 based on Arden Pope's JAMA paper in 2002 follow up from 1982 to 1998....

Let me know if it looks clear enough?

Yuanli

-----Original Message----- From: Rick Burnett [ mailto:Rick.Burnett@hc

- sc.gc.ca ] Sent: Wednesday, August 25, 2010 6:29 PM To: Michelle Turner Cc: Yuanli Shi Subject: Re: FW: Fw: Urgent Request for Information from your 2009 study

thanks Michelle/Yunali - it would be great ot get rid of this request

Michelle Turner

<mturner@uottawa.

ca> To Yuanli Shi <syuanli@uottawa.ca>, 2010-08-25 05:21 Rick Burnett PM <Rick.Burnett@hc-sc.gc.ca> Page 3 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...cc

Subject FW: Fw: Urgent Request for Information from your 2009 study

Hi Yuanli, Please see email below from Rick. I believe that for the 58 MSAs and 116 MSAs from Pope 2002 paper with follow-up through 1998, they would like the following. Why don't we do this first to get it out of the way, then we'll move on CARB, Michelle

-----Original Message----- From: Rick Burnett [ mailto:Rick.Burnett@hc

- sc.gc.ca ] Sent: Wednesday, August 25, 2010 12:11 PM To: susan.gapstur@cancer.org Cc: cap3@email.byu.edu; Daniel Krewski; jerrett@usc.ca; MIchael.Thun@cancer.org; Michelle Turner Subject: Re: Fw: Urgent Request for Information from your 2009 study

that is correct, I will create the file and send it to you, thanks

susan.gapstur@can
cer.org

To 2010-08-25 11:44 Rick Burnett AM <Rick.Burnett@hc-sc.gc.ca>

cc cap3@email.byu.edu, dkrewski@uottawa.ca, jerrett@usc.ca, Page 4 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...MIchael.Thun@cancer.org, "Michelle

Turner" <mturner@uottawa.ca>

Subject Re: Fw: Urgent Request for Information from your 2009 study

Hi Rick,

As we understand it they are requesting....

1) The total number of all cause deaths and number of participants for each of 58 MSA's for the period from 1979-83 (NOT FOR EACH YEAR). IS
THIS
CORRECT?

2) The total number of all cause deaths and number of participants for each of 116 MSA's for the period from 1999-2000 (NOT FOR EACH YEAR). IS
THIS
CORRECT?

3) Concentration of PM2.5 for the MSAs as indicated above. (Is that the means, medians, ranges?)

Assuming that 1 and 2 above are correct, then we would be comfortable with you providing such data for those MSAs in which the total number if deaths was 10 or more.

I assume these would all just be summary statistics. It would be nice if we could see what you are going to send to EPA before you send it off just so that we have a record of it. Page 5 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...Let me know what you (or anyone else) think.

Thanks

Sue

Susan Gapstur | Vice President, Epidemiology Research Program

National Home Office | American Cancer Society, Inc.

250 Williams Street, Atlanta, GA 30303 | cancer.org

404.329.5741 | fax: 404.327.6450

(Embedded image moved to file: pic29733.gif)

Rick Burnett <Rick.Burnett@hc-sc.gc

.ca>

To Susan.gapstur@cancer.org, 08/23/2010 03:05 PM Michelle.Thun@cancer.org

cc "Michelle Turner" <mturner@uottawa.ca>, jerrett@usc.ca, dkrewski@uottawa.ca, cap3@email.byu.edu

Subject Fw: Urgent Request for Information from Page 6 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...your 2009 study

Susan/Michelle: EPA is interested in using results from our analysis of the CPSII cohort and air pollution in their standard setting process and are interested in a concentratoion-response figure on PM2.5 and mortality we published in JAMA in 2002 and in our recent HEI report.

They have requested some additional information that they feel would help them - the number of subjects and deaths by MSA in addition to the pollution values assigned to these MSAs

this information is easy for us to produce but if it is given to EPA then effectively it will be made public

so I am asking what you think about this request and whether we should proceed with it

thanks for your attention to this matter ----- Forwarded by Rick Burnett/HC-SC/GC/CA on 2010-08-23 03:01 PM -

----

Rajan.Pradeep@epa mail.epa.gov

To 2010-08-20 12:36 Rick.Burnett@hc-sc.gc.ca

PM

cc Martin.Karen@epamail.epa.gov, Hubbell.Bryan@epamail.epa.gov,

HassettSipple.Beth@epamail.epa.gov Page 7 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...Subject Urgent Request for Information from your 2009 study

Dear Dr. Burnett,

Subsequent to our recent discussions with you regarding the confidence bounds associated with a PM2.5 concentration-response function, we

were asked by our CASAC to consider information on the concentrations that were most influential in generating the health effect estimates reported in individual epidemiological studies.

Consequently, we are interested in examining the distribution of PM2.5 concentrations in conjunction with the number of deaths among the cohort members included in your published study “Extended Follow-Up and Spatial Analysis of the American Cancer Society Study Linking Particulate Air Pollution and Mortality.”

Specifically, if available we are interested in receiving from you Page 8 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...the total number of all-cause deaths and the total number of ACS participants for each of the 58 MSAs included in your analysis of 1979-1983 PM2.5 data. We are also interested in receiving from you the total number of all-cause deaths and the total number of ACS participants for each of 116 MSAs in your analysis of 1999-2000 PM2.5 data.

If you find that is not feasible to provide us with the MSA- s pecific number of deaths we would appreciate receiving just the MSA-specific number of study participants across the entire study period.

We anticipate that this information would provide us with an understanding of the distribution of PM2.5 concentrations linked with the health effect among your study population and therefore an indication of which PM2.5 concentrations are likely to be most influential in generating the reported health effect estimates.

Thanks in advance for your help!

Pradeep Rajan Page 9 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...Pradeep Rajan, ScD Ambient Standards Group Health and Environmental Impacts Division Office of Air Quality Planning and Standards U.S. EPA mail code: C504-06 RTP, NC 27711 office: 919-541-2580 fax: 919-541-0237 email: rajan.pradeep@epa.gov (See attached file: pic29733.gif) (See attached file: acs_pm25_80_msa.csv)(See attached file: acs_pm25_00_msa.csv) (See attached file: acs_pm25_80_msa58.csv)(See attached file: acs_pm25_00_msa116.csv) Page 10 of 10

12/21/2010 file://C:\Documents and Settin g s\tcrabtre\Local Settin g s\Tem p \notesFCBCEE\~web7521.

...