**Exhibit10.48****FIFTH AMENDED SECURITY AGREEMENT**     **THIS FIFTH AMENDED SECURITY AGREEMENT**(this “**Agreement**”) is made as of June 1, 2007, by andamong Sutura, Inc., a Delaware corporation (“**Sutura**”), Pandora Select Partners, L.P., a BritishVirgin Islands limited partnership (“**Pandora**”), Whitebox Hedged High Yield Partners, L.P., aBritish Virgin Islands limited partnership (“**WHHY**”), Whitebox Convertible Arbitrage Partners, L.P.,a British Virgin Islands limited partnership (“**WCAP**”), Whitebox Intermarket Partners, L.P., aBritish Virgin Islands limited partnership (“**WIP**”), Gary S. Kohler (“**Kohler**”) and Scot W. Malloy(“**Malloy**”), each residents of the State of Minnesota, and Synapse Capital, LLC, a Californialimited liability company, as agent (“**Synapse Secured Party**”). Pandora, WHHY, WCAP, WIP, Kohlerand Malloy are referred to herein individually as a “**Whitebox Secured Party**” and together as the"**Whitebox Secured Parties**.” Synapse Secured Party and the Whitebox Secured Parties are referred toherein individually as a “**Secured Party**” and together as the “**Secured Parties**.”**RECITALS**     A. Sutura, Pandora, WHHY, WCAP, WIP, Kohler and Malloy entered into a Purchase Agreement datedSeptember 17, 2004 (the “**Original Purchase Agreement**”), pursuant to which Pandora, WHHY, WCAP, WIP,Kohler and Malloy each purchased a convertible promissory note (each, an “**Original Note**” andtogether, the “**Original Notes**”) and a warrant to purchase shares of Sutura’s common stock (“**SuturaStock**”) from Sutura in consideration of a collective $6,550,000 loan (the “**Original Loan**”).     B. As a condition to making the Original Loan, Sutura pledged to the Whitebox Secured Partiesall of Sutura’s assets pursuant to the terms of a Security Agreement dated September 17, 2004 (the**“Original Security Agreement**”).     C. Sutura, Pandora, WHHY and WIP entered into a second Purchase Agreement dated March 24, 2005(the “**Second Purchase Agreement**”), pursuant to which Pandora, WHHY and WIP each purchased anadditional convertible promissory note (each, a “**March 2005 Note**” and together, the “**March 2005Notes**”) and an additional warrant to purchase Sutura Stock in consideration a collective $3,000,000new loan (the “**March 2005 Loan**”).     D. Sutura and the Whitebox Secured Parties entered into an Amended Security Agreement datedMarch 24, 2005 (the **“March 2005 Security Agreement"**) to supersede and replace the Original SecurityAgreement.     E. Sutura, Pandora, WHHY, WCAP and WIP entered into a third Purchase Agreement dated September7, 2005 (the **“Third Purchase Agreement"**), pursuant to which Pandora, WHHY, WCAP and WIP eachpurchased an additional convertible promissory note (each, a **“September 2005 Note”**and together,the **“September 2005 Notes”**) and an additional warrant to purchase the Sutura’s Common Stock inconsideration of a collective $7,000,000 new loan (the “**September 2005 Loan**”).
 

 
     F. Sutura and the Whitebox Secured Parties entered into a Second Amended Security Agreementdated September 7, 2005 (the **“September 2005 Security Agreement”**) to supersede and replace theMarch 2005 Security Agreement     G. Pandora, WHHY, WCAP and WIP each purchased additional convertible promissory notes fromSutura on June 7, 2006, June 28, 2006 and July 31, 2006 in consideration of collective loans of$500,000, $500,000 and $1,160,000, respectively (the **“June/July 2006 Loans”**) to Sutura.     H. On June 7, 2006, Sutura and the Whitebox Secured Parties entered into a Third AmendedSecurity Agreement (the **“June 2006 Security Agreement"**) to supersede and replace the September 2005Security Agreement.     I. Sutura, Pandora, WHHY, WCAP and WIP entered into a Purchase Agreement dated August 25, 2006(the “**Fourth Purchase Agreement**”), pursuant to which Pandora, WHHY, WCAP and WIP each convertedtheir respective June/July 2006 Loans, converted certain amounts of interest due under prior notesand purchased shares of Sutura’s common stock, par value $0.001 per share.     J. Sutura, Pandora, WHHY and WIP entered into a Purchase Agreement dated December 13, 2006(the “**Fifth Purchase Agreement**”), pursuant to which Pandora, WHHY and WIP each purchased additionalconvertible promissory notes on December 13, 2006 (each, a “**December 2006 Note**” and together, the”**Decembe**r **2006 Notes**”) and March 5, 2007 (each, a “**March 2007 Note**” and together, the “**March 2007Notes**”)in consideration of a collective $3,000,000 new loan (the “**December 2006 Loan**”).     K. Sutura and the Whitebox Secured Parties entered into a Fourth Amended Security Agreement(the “**December 2006 Security Agreement**”) to supersede and replace the June 2006 Security Agreement.     L. On the date hereof Sutura and the Synapse Secured Party have entered into a SettlementAgreement of even date herewith with certain other parties signatory thereto pursuant to whichSutura has issued to the Synapse Secured Party (as agent for certain other parties to theSettlement Agreement) a convertible promissory note (the “**Synapse Note**”) in the principal amount of$400,000.     M. Sutura and the Secured Parties desire to enter into this Agreement to supersede and replacethe December 2006 Security Agreement.     **NOW, THEREFORE**, in consideration of the agreements herein and in reliance upon therepresentations and warranties set forth herein and therein, the parties agree as follows:
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**ARTICLE 1.****DEFINED TERMS**     **1.1 DEFINITIONS**. Unless otherwise defined herein or unless the context otherwise requires,terms used in this Agreement, including its preamble and recitals, have the meanings provided inthe Uniform Commercial Code in effect in the State of Delaware (the “**UCC**”). In addition, thefollowing terms when used in this Agreement, including its preamble and recitals, shall have thefollowing meanings:     “**Loan Documents**” means this Agreement, the Fifth Amended Patent and Trademark SecurityAgreement of this date among Sutura and the Secured Parties (the “**Patent and TrademarkSecurity Agreement**”), the Notes and the Synapse Note.     “**Notes**” means the Original Notes, the March 2005 Notes, September 2005 Notes, theDecember 2006 Notes, the March 2007 Notes and any future Notes issued to any Whitebox Party(as such term is defined in the Synapse Note).     “**Obligations**” means the payment and other performance obligations under the LoanDocuments, whether now existing or hereafter created.**ARTICLE 2.**