Propiconazole 

PC Code: 122101 

Dietary Exposure and Risk Assessment DP Number: D403630 

UNITED STATES ENVIRONMENTAL PROTECTION 

AGENCY 

WASHINGTON, D.C. 20460 

Office of Chemical Safety and Pollution Prevention 

MEMORANDUM 

Date: February 27, 2013 

SUBJECT: Propiconazole: Acute and Chronic Aggregate Dietary (Food and 

Drinking Water) Exposure and Risk Assessments for Cereal Grains. 

PC Code: 122101 

Decision No.: 460659 

Petition No.: 2F7975 

DP Barcode: D403630 

Risk Assessment Type: Dietary assessment 

TXRNo.: N/A 

Registration No.: I 00-617 and 100-1324 

Regulatory Action: Amended Section 3 

Case No.: 3125. 

CAS No.: 60207-90-1 

MRID No.: N/A 40 CFR: § 180.434 . L 

FROM: Thurston G. Morton, Chemist ~ffj-- Risk Assessment Branch IV 

Health Effects Division (7509P) 

THROUGH: Tom Bloem, ._ f~ William Cutchin, Chemist ;~ Dietary Exposure Science Advisory Council (DESAC) 

Health Effects Division (7509P) 

And 

Susan Hummel, Senior Scientist 

Elissa Reaves, PhD, Branch Chief 

Risk Assessment Branch IV 

Health Effects Division (7509P) 

TO: Heather Garvie 

Fungicide Branch 

Registration Division (7505P) 

This document provides the Health Effects Division's (RED's) dietary exposure risk 

assessment of the amended use of propiconazole on cereal grains. 

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Executive Summary

Propiconazole acute and chronic dietary exposure assessments were conducted using the 

Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 

DEEM-FCIDTM, Version 3.16, which incorporates consumption data from USDA’s 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA). This dietary survey was conducted from 2003 to 2008. The 

analyses were performed to support the amended Section 3 registration on cereal grains. 

Attached are acute and chronic dietary risk assessments for this new use. This dietary 

assessment is for residues of propiconazole and its metabolites convertible to 2,4-

dichlorobenzoic acid (2,4-DCBA), expressed as propiconazole equivalents. The common 

metabolites- triazole, triazolylalanine (TA), triazolylacetic acid (TAA), and 

triazolylpyruvic acid are also residues of concern. Since these are common metabolites 

from several triazole pesticides, the risk assessment for triazoles will be assessed 

separately. 

 

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

An acute dietary analysis for propiconazole residues of concern was conducted using 

tolerance levels and 100 %CT for all existing and proposed uses. The acute population 

adjusted dose (PAD) is 0.3 mg/kg/day for all population subgroups (includes females 13-

49 years). The results of the analysis indicate that acute risk from the dietary exposure 

(food and water) to propiconazole from the existing and proposed uses did not exceed 

HED’s level of concern for the general U.S. population or any population subgroup. At 

the 95th percentile, the exposure to the general U.S. population is 26 % of the aPAD; the 

highest exposed subgroup (Children 1-2 yrs old) is 85 % of the aPAD. 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

A chronic dietary analysis for propiconazole residues of concern was conducted using 

tolerance levels for some commodities, average field trial residues for the remaining 

commodities, and 100 %CT for all existing and proposed uses. The chronic population 

adjusted dose (cPAD) is 0.1 mg/kg/day. Results of the analysis indicate that chronic risk 

from the dietary exposure (food and water) to propiconazole from the existing and 

proposed uses did not exceed HED’s level of concern for the general U.S. population or 

any population subgroup. The exposure to the general U.S. population is 7.4 % of the 

cPAD, and the most highly exposed subgroup (Children 1-2 yrs old) is 24 % of the 

cPAD. 

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

The HED Carcinogenicity Peer Review Committee (CPRC) classified propiconazole as 

Group C - possible human carcinogen and recommended that for the purpose of risk 

characterization the Reference Dose (RfD) approach should be used and would be 

protective. 
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I. Introduction

Propiconazole is a triazole-type fungicide that provides broad spectrum disease control 

through inhibition of sterol biosynthesis in fungi. It is registered to Syngenta Crop 

Protection for the control of fungal diseases on a variety of crops. This dietary exposure 

assessment is for an amended use on cereal grains. 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the PAD. The PAD is equivalent to 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or 

safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk 

exceeds one in one million. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see 

SOP 99.6 (20-AUG-1999). 

The most recent dietary risk assessment for propiconazole was conducted by T. Morton 

(DP 403182, 11/15/12). 

II. Residue Information

Residue Data used for Acute and Chronic Assessments:

The acute assessment was based on the assumption of tolerance-level residues for all 

commodities with existing and proposed tolerances and 100% crop treated (%CT) for all 

commodities. The chronic assessment was based on tolerance level residues for some 

commodities, average field trial residues for the remaining commodities, and 100% crop 

treated (%CT). The existing tolerances are listed in 40 CFR §180.434. The proposed 

new tolerance levels used in the DEEM are presented in Table 1. DEEM default 

processing factors from DEEM (Version 7.81) were used for all processed commodities 

that do not have individual tolerances except for citrus juices which were reduced to 1 

since no concentration of propiconazole residues occurred. 
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Propiconazole existing tolerances: 

§ 180.434 Propiconazole; tolerances for residues.

(a) General . Tolerances are established for the combined residues of the fungicide 1-[[2-

(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl] methyl]-1H-1,2,4-triazole and its 

metabolites determined as 2,4-dichlorobenzoic acid and expressed as parent compound in 

or on the following commodities: 

Commodity Parts per million

Almond, hulls 7.0

Banana 0.2

Barley, bran 0.6

Barley, grain 0.3

Barley, hay 1.4

Barley, straw 10

Bean, dry seed 0.40

Bean, snap 0.70

Bean, succulent shelled 0.10

Beet, garden, roots 0.30

Beet, garden, tops 5.5

Beet, sugar, dried pulp 1.0

Beet, sugar, molasses 1.5

Beet, sugar, roots 0.3

Beet, sugar, tops 10

Bushberry, subgroup 13-07B 1.0

Caneberry, subgroup 13-07A 1.0

Carrot, roots 0.25

Cattle, fat 0.05

Cattle, kidney 2.0

Cattle, liver 2.0

Cattle, meat 0.05

Cattle, meat byproducts, except liver and kidney 0.05

Cilantro, leaves 13

Citrus, oil 1000

Corn, field, forage 12

Corn, field, grain 0.2

Corn, field, stover 30

Corn, pop, grain 0.2

Corn, pop, stover 30

Corn, sweet, forage 6.0

Corn, sweet, kernel plus cob with husks removed 0.1
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Corn, sweet, stover 30

Fruit, citrus, group 10-10 8.0

Fruit, stone, group 12, except plum 4.0

Goat, fat 0.05

Goat, kidney 2.0

Goat, liver 2.0

Goat, meat 0.05

Goat, meat byproducts, except liver and kidney 0.05

Grain, aspirated fractions 30

Grass, forage 0.5

Grass, hay 0.5

Grass, straw 40

Hog, kidney 0.2

Hog, liver 0.2

Horse, fat 0.05

Horse, kidney 2.0

Horse, liver 2.0

Horse, meat 0.05

Horse, meat byproducts, except liver and kidney 0.05

Leaf petioles subgroup 4B 5.0

Low growing berry subgroup 13-07G, except cranberry 1.3

Milk 0.05

Mushroom 0.1

Nut, tree, group 14 0.1

Oat, forage 1.7

Oat, grain 0.3

Oat, hay 1.4

Oat, straw 10

Onion, bulb subgroup 3-07A 0.2

Onion, green, subgroup 3-07B 9.0

Parsley, fresh leaves 13

Parsley, dried leaves 35

Peanut 0.2

Peanut, hay 20

Peppermint, tops 10.0

Pineapple 4.5

Pineapple, process residue 7.0

Pistachio 0.1

Plum 0.60

Rice, bran 15

Rice, grain 7.0
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Rice, hulls 20

Rice, straw 18

Rye, bran 0.6

Rye, forage 1.7

Rye, grain 0.3

Rye, straw 10

Sheep, fat 0.05

Sheep, kidney 2.0

Sheep, liver 2.0

Sheep, meat 0.05

Sheep, meat byproducts, except liver and kidney 0.05

Sorghum, grain, forage 12

Sorghum, grain, grain 3.5

Sorghum, grain, stover 15

Soybean, forage 11

Soybean, hay 30

Soybean, seed 2.0

Spearmint, tops 10.0

Tomato 3.0

Vegetable, foliage of legume, group 7 30

Wheat, bran 0.6

Wheat, forage 1.7

Wheat, grain 0.3

Wheat, hay 1.4

Wheat, straw 10

(b) Section 18 emergency exemptions . Time-limited tolerances are established for 

residues of propiconazole (1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl] 

methyl]-1H-1,2,4-triazole) and its metabolites determined as 2,4-dichlorobenzoic acid 

and expressed as parent compound, in connection with use of the pesticide under section 

18 emergency exemptions granted by EPA. The tolerances will expire and are revoked on 

the dates specified in the following table: 

Commodity Parts per million Expiration/revocation date

Avocado 10 12/31/13

Nectarine 2.0 12/31/13

Peach 2.0 12/31/13

(c) Tolerances with regional registrations . A tolerance with regional registration, as 

defined in § 180.1(l), is established for residues of 1-[[2-(2,4-dichlorophenyl)-4-propyl1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole and its metabolites determined as 2,4-
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dichlorobenzoic acid and expressed as parent compound, in or on the following 

commodities: 

Commodity Parts per million

Cranberry 1.0

Rice, wild, grain 0.5

(d) Indirect or inadvertent residues . Tolerances are established for the combined 

residues of the fungicide 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl] methyl]-

1H-1,2,4-triazole and its metabolites determined as 2,4-dichlorobenzoic acid and 

expressed as parent compound in or on the following commodities when present therein 

as a result of application of propiconazole to growing crops in paragraphs (a) and (c) of 

this section: 

Commodity Parts per million

Alfalfa, forage 0.1

Alfalfa, hay 0.1

[71 FR 55306, Sept. 22, 2006, as amended at 72 FR 20439, Apr. 25, 2007; 74 FR 12613, 

Mar. 25, 2009; 75 FR 80346, Dec. 22, 2010; 76 FR 27268, May 11, 2011; 77 FR 38204, 

Jun. 27, 2012] 

Table 1a. Tolerance Summary for Propiconazole for Petition 1E7892 

Crop Commodity 

Established 

Tolerance 

(ppm) 

HED 

Recommended 

Tolerance (ppm) 

Comments 

(Correct Commodity Definition)

Tolerances under §180.434(a) to be Added

Sugarcane, cane none 0.40 Data are adequate to support the use. 

Table 1b. Tolerance Summary for Propiconazole for Petition 2F7975 

Crop Commodity 

Proposed or 

Established 

Tolerance 

(ppm) 

HED 

Recommended 

Tolerance (ppm) 

Comments 

(Correct Commodity Definition)

Tolerances under §180.434(a) to be Added

Barley, bran none 6 Data are adequate to support the use. 

Barley, grain 0.3 3 Data are adequate to support the use. 

Oat, grain 0.3 3 Data are adequate to support the use. 
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Average Field Trial Residues used in the chronic dietary exposure assessment: 

Beets, garden and sugar..............0.12 ppm 

 Carrot..................................0.10 ppm 

 Onion, green and leek................2.43 ppm 

 Parsley, fresh leaves..................3.65 ppm 

 Crop Group 4B........................1.01 ppm 

 Soybean seed...........................0.26 ppm 

 Tomato.................................0.791 ppm 

 Grapefruit..............................1.18 ppm 

 Lemon..................................1.79 ppm 

 Lime....................................2.34 ppm 

 Orange.................................2.34 ppm 

 Cherry..................................0.563 ppm 

 Apricot, nectarine, peach............0.961 ppm 

 Plum....................................0.183 ppm 

 Blueberry...............................0.35 ppm 

 Cranberries..............................0.32 ppm 

 Other small berries.....................0.36 ppm 

 Strawberry...............................0.35 ppm 

 Almond..................................0.038 ppm 

 Corn, field and pop.....................0.036 ppm 

 Rice.......................................1.49 ppm 

 Sorghum..................................1.27 ppm 

 Wheat.....................................0.043 ppm 

 Pineapple.................................1.03 ppm 

 Sugarcane.................................0.12 ppm 

III. Drinking Water Data 

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: 

“Drinking Water Assessment for Propiconazole Uses on Florida Avocado – Section 18 

Emergency Exemption” (Jim Lin, 07/15/10, D379850) and incorporated directly into this 

dietary assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 

In the case of propiconazole, turf, a previously registered crop, has the highest application 

rate (6.285 lb a.i./A, 8 applications of 0.786 lb a.i../A per year with a 14-day interval 

between applications) ((DP 325821,328690, Dated 07/07/2006). The proposed new use 

does not result in higher EDWCs than those estimated for turf uses. 

The estimated surface water drinking water concentrations for propiconazole are: 

55.78 ug /L for the 1 in 10 year annual peak concentration (acute) 

21.61 ug /L for the 1 in 10 year annual mean concentration (non-cancer chronic) and 

13.24 ug /L for the 30 year annual mean concentration (cancer chronic). 

The SCI-GROW estimated ground water drinking water concentrations for propiconazole 

are not expected to exceed 0.64 μg/L 
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The highest estimates from surface water (acute, 55.8 ppb and chronic, 21.6 ppb) are 

directly entered into the exposure model to assess the contributions from drinking water. 

The model and its description are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

IV. DEEM-FCIDTM Program and Consumption Information

Propiconazole acute and chronic dietary exposure assessments were conducted using the 

Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 

DEEM-FCIDTM, Version 3.16, which incorporates consumption data from USDA’s 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA). This dietary survey was conducted from 2003 to 2008. The data 

are based on the reported consumption of more than 20,000 individuals over two nonconsecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPAdefined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or 

wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population 

subgroups, but for acute exposure assessment are retained as individual consumption 

events. Based on analysis of the 2003-2008 WWEIA consumption data, which took into 

account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 
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all tiers of analysis. However, for tiers 1 and 2, any significant differences in user vs. per 

capita exposure and risk are specifically identified and noted in the risk assessment. 

V. Toxicological Information 

HED’s Hazard Identification Assessment Review Committee (HIARC) concluded that 

the toxicology database for propiconazole is complete for FQPA assessment. Endpoints 

and dose response have been selected for acute and chronic dietary exposures. 

The HIARC also concluded that the database was adequate to characterize any potential 

for prenatal or postnatal risk for infants and children. There is low concern for preand/or postnatal toxicity resulting from exposure to propiconazole, and no residual 

uncertainties were identified. The Special FQPA factor is thus 1X. The HIARC had 

previously determined that an acute neurotoxicity (ACN) study was required based on 

neurotoxic signs in pregnant rats administered high propiconazole doses (360 mg/kg/day) 

during gestation. HIARC had determined that for acute (single dose) and short-term 

exposure scenarios a 3X database uncertainty factor (UFDB) was adequate to account for 

the lack of the ACN. In September 2005 the ACN was submitted to the Agency and 

reviewed. The study confirms that neurotoxic signs are observed at high doses, but there 

was no neuropathology and there were no effects on neurobehavioral parameters. 

Accordingly, the propiconazole risk assessment team determined that a developmental 

neurotoxicity study was not necessary and the database uncertainty factor for acute and 

short-term scenarios was removed. 

The HED Carcinogenicity Peer Review Committee (CPRC) classified propiconazole as 

Group C - possible human carcinogen and recommended that for the purpose of risk 

characterization the reference Dose (RfD) approach should be used and would be 

protective.
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Table 2 Summary of Toxicological Doses and Endpoints for Propiconazole for Use in Dietary 

Exposure Risk Assessments 

Exposure/ 

Scenario 

Point of 

Departure 

Uncertainty/FQPA 

Safety Factors 

RfD, PAD, Level 

of Concern 

Study and Toxicological 

Effects 

Acute 

Dietary 

(General 

Population, 

including 

Infants and 

Children) 

NOAEL= 

30 

mg/kg/day 

UFA= 10x 

UFH= 10x 

FQPA SF= 1x 

Acute RfD = 0.3 

mg/kg/day 

aPAD =0.3 

mg/kg/day 

Acute neurotoxicity study 

LOAEL = 100 mg/kg/day based 

on clinical signs of toxicity 

(piloerection in one male, 

diarrhea in one female, tip toe 

gait in 3 females). 

Acute 

Dietary 

(Females 13-

49 years of 

age) 

NOAEL = 

30 

mg/kg/day 

UFA= 10x 

UFH= 10x 

FQPA SF= 1x 

Acute RfD = 0.3 

mg/kg/day 

aPAD =0.3 

mg/kg/day 

Developmental Toxicity Study - 

Rats. 

LOAEL = 90 mg/kg/day based 

on increased incidence of 

rudimentary ribs, un-ossified 

sternebrae, as well as increased 

incidence of shortened and 

absent renal papillae and 

increased cleft palate. 

Chronic 

Dietary (All 

Populations) 

NOAEL= 

10 

mg/kg/day 

UFA= 10x 

UFH= 10x 

FQPA SF= 1x 

Chronic RfD = 0.1 

mg/kg/day 

cPAD = 

0.1mg/kg/day 

24-month oncogenicity study 

on CD-1 mice. 

LOAEL = 50 mg/kg/day based 

on non-neoplastic liver effects 

(increased liver weight in males 

and increase in liver lesions: 

masses/raised areas/ 

swellings/nodular areas 

mainly). 

Cancer (oral, dermal, 

inhalation) 

Classification: Group C, possible human carcinogen, RfD approach for risk 

characterization. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response 

data and used to mark the beginning of extrapolation to determine risk associated with lower 

environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest 

observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human 

(intraspecies). UFH = potential variation in sensitivity among members of the human population 

(interspecies). UFDB = to account for the absence of key data (i.e., lack of a critical study). FQPA SF = 

FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. 

N/A = not applicable. 

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure 

of the U.S. population and various population subgroups. The results reported in Tables 

3 and 4 are for the general U.S. Population, all infants (<1 year old), children 1-2, 

children 3-4, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ 

years. 

At the 95th percentile, the acute dietary exposure (food and water) to general US 

population is 26 % of the aPAD, and the most highly exposed subgroup, Children 1-2 yrs 

old, is 85 % of the aPAD. The chronic dietary exposure to general US population is 7.6 
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% of the cPAD, and the most highly exposed subgroup, Children 1-2 yrs old, is 24 % of 

the cPAD. All the dietary risk estimates are below 100% of the PADs. 

These analyses are highly conservative dietary exposure assessments. Further refinement 

to the analyses could be made through the use of anticipated residues, incorporation of 

percentages of crops treated with propiconazole, and/or monitoring data that better reflect 

residues at the time of consumption. Since risk estimates are well below HED’s level of 

concern, a more highly refined analysis is not needed at this time. 

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

Table 3. Results of Acute Dietary Exposure Analysis for Food and Drinking Water 

Population Subgroup aPAD (mg/kg/day) 

95th Percentile 

Exposure (mg/kg/day) % aPAD 

General U.S. Population 

0.3 

0.077562 26 

All Infants (< 1 year old) 0.108099 36 

Children 1-2 years old 0.253533 85 

Children 3-5 years old 0.194271 65 

Children 6-12 years old 0.106036 35 

Youth 13-19 years old 0.073595 25 

Adults 20-49 years old 0.061233 20 

Adults 50+ years old 0.050898 17 

Females 13-49 years old 0.060552 20 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

Table 4. Results of Chronic Dietary Exposure Analysis for Food and Drinking Water 

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) % cPAD 

General U.S. Population 

0.1 

0.007432 7.4 

All Infants (< 1 year old) 0.010280 10 

Children 1-2 years old 0.023718 24 

Children 3-5 years old 0.019121 19 

Children 6-12 years old 0.009941 9.9 

Youth 13-19 years old 0.006022 6.0 

Adults 20-49 years old 0.006180 6.2 

Adults 50+ years old 0.005618 5.6 

Females 13-49 years old 0.005622 5.6 

VII. Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, 100% CT, and empirical or 

DEEM default processing factors. The chronic analysis assumed average field trial 

residues for some commodities, tolerance-level residues for the remaining commodities, 

100% CT, and empirical or DEEM default processing factors. Therefore, these 

analyses are considered conservative. Since risk estimates are well below HED’s level of 

concern they do not warrant the need for further refinement at this time. 
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VIII. Conclusions

These dietary analyses demonstrate that the requested amended use for propiconazole 

will not result in dietary risk estimates that exceed HED’s level of concern for any of the 

regulated population subgroups, including those comprised of infants and children. A 

summary of the dietary exposure analyses is given in Table 5. 

Table 5. Summary of Dietary Exposure and Risk for Propiconazole FOOD PLUS DRINKING WATER. 

Population Subgroup 

Acute Dietary (95th 

Percentile) Chronic Dietary Cancer 

Dietary 

Exposure 

(mg/kg/day) 

% aPAD 

Dietary 

Exposure 

(mg/kg/day) 

% cPAD 

Dietary 

Exposure 

(mg/kg/day) 

Risk 

General U.S. Population 0.077562 26 0.007432 7.4 

N/A 

All Infants (< 1 year old) 0.108099 36 0.010280 10 

Children 1-2 years old 0.253533 85 0.023718 24 

Children 3-5 years old 0.194271 65 0.019121 19 

Children 6-12 years old 0.106036 35 0.009941 9.9 

Youth 13-19 years old 0.073595 25 0.006022 6.0 

Adults 20-49 years old 0.061233 20 0.006180 6.2 

Adults 50+ years old 0.050898 17 0.005618 5.6 

Females 13-49 years old 0.060552 20 0.005622 5.6 

IX. List of Attachments

Attachment 1. Acute Food plus Water Residue Input file. 

Attachment 2. Acute Results file. 

Attachment 3. Chronic Food plus Water Residue Input file. 

Attachment 4. Chronic Results file. 

 
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Attachment 1. Acute Food plus Water Residue Input file. 

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\122101 

Propiconazole\Petition 2F7975 Cereal Grains\122101 Acute 2F7975 Oct 2012.R08 

Chemical: Propiconazole 

RfD(Chronic): .1 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .3 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 10-16-2012/13:48:00 Program ver. 3.16, 03-08-d 

----------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ ------- 

0101050000 1AB Beet, garden, roots 0.300000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.300000 1.000 1.000 

0101052000 1A Beet, sugar 0.300000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 1.500000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 1.500000 1.000 1.000 

0101078000 1AB Carrot 0.250000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.250000 1.000 1.000 

0101079000 1AB Carrot, juice 0.250000 1.000 1.000 

0200051000 2 Beet, garden, tops 5.500000 1.000 1.000 

0301165000 3A Garlic, bulb 0.200000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.200000 1.000 1.000 

0301237000 3A Onion, bulb 0.200000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.200000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.200000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.200000 9.000 1.000 

0302103000 3B Chive, fresh leaves 9.000000 1.000 1.000 

0302198000 3B Leek 9.000000 1.000 1.000 

0302239000 3B Onion, green 9.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 9.000000 1.000 1.000 

0401248000 4A Parsley, leaves 13.000000 1.000 1.000 

0402076000 4B Cardoon 5.000000 1.000 1.000 

0402085000 4B Celery 5.000000 1.000 1.000 

0402085001 4B Celery-babyfood 5.000000 1.000 1.000 

0402086000 4B Celery, juice 5.000000 1.000 1.000 

0402087000 4B Celtuce 5.000000 1.000 1.000 

0402152000 4B Fennel, Florence 5.000000 1.000 1.000 

0402322000 4B Rhubarb 5.000000 1.000 1.000 

0402367000 4B Swiss chard 5.000000 1.000 1.000 

0600347000 6 Soybean, seed 2.000000 1.000 1.000 

0600349000 6 Soybean, soy milk 2.000000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 2.000000 1.000 1.000 

0600350000 6 Soybean, oil 2.000000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 2.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.700000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.700000 1.000 1.000 

0601349500 6AB Soybean, vegetable 2.000000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.100000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.100000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.100000 1.000 1.000 

0603030000 6C Bean, black, seed 0.400000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.400000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.400000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.400000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.400000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.400000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.400000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.400000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.400000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.400000 1.000 1.000 

0603098000 6C Chickpea, seed 0.400000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.400000 1.000 1.000 

0603099000 6C Chickpea, flour 0.400000 1.000 1.000 

0603182000 6C Guar, seed 0.400000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.400000 1.000 1.000 

0603203000 6C Lentil, seed 0.400000 1.000 1.000 

0603348000 6C Soybean, flour 2.000000 1.000 1.000 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 15 of 23 

0603348001 6C Soybean, flour-babyfood 2.000000 1.000 1.000 

0801374000 8A Tomatillo 3.000000 1.000 1.000 

0801375000 8A Tomato 3.000000 1.000 1.000 

0801375001 8A Tomato-babyfood 3.000000 1.000 1.000 

0801376000 8A Tomato, paste 3.000000 5.400 1.000 

0801376001 8A Tomato, paste-babyfood 3.000000 5.400 1.000 

0801377000 8A Tomato, puree 3.000000 3.300 1.000 

0801377001 8A Tomato, puree-babyfood 3.000000 3.300 1.000 

0801378000 8A Tomato, dried 3.000000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 3.000000 14.300 1.000 

0801379000 8A Tomato, juice 3.000000 1.500 1.000 

1001106000 10A Citron 8.000000 1.000 1.000 

1001107000 10A Citrus hybrids 8.000000 1.000 1.000 

1001108000 10A Citrus, oil 1000. 1.000 1.000 

1001240000 10A Orange 8.000000 1.000 1.000 

1001241000 10A Orange, juice 8.000000 1.000 1.000 

1001241001 10A Orange, juice-babyfood 8.000000 1.000 1.000 

1001242000 10A Orange, peel 8.000000 1.000 1.000 

1001369000 10A Tangerine 8.000000 1.000 1.000 

1001370000 10A Tangerine, juice 8.000000 1.000 1.000 

1002197000 10B Kumquat 8.000000 1.000 1.000 

1002199000 10B Lemon 8.000000 1.000 1.000 

1002200000 10B Lemon, juice 8.000000 1.000 1.000 

1002200001 10B Lemon, juice-babyfood 8.000000 1.000 1.000 

1002201000 10B Lemon, peel 8.000000 1.000 1.000 

1002206000 10B Lime 8.000000 1.000 1.000 

1002207000 10B Lime, juice 8.000000 1.000 1.000 

1002207001 10B Lime, juice-babyfood 8.000000 1.000 1.000 

1003180000 10C Grapefruit 8.000000 1.000 1.000 

1003181000 10C Grapefruit, juice 8.000000 1.000 1.000 

1003307000 10C Pummelo 8.000000 1.000 1.000 

1201090000 12A Cherry 4.000000 1.000 1.000 

1201090001 12A Cherry-babyfood 4.000000 1.000 1.000 

1201091000 12A Cherry, juice 4.000000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 4.000000 1.500 1.000 

1202012000 12B Apricot 4.000000 1.000 1.000 

1202012001 12B Apricot-babyfood 4.000000 1.000 1.000 

1202013000 12B Apricot, dried 4.000000 6.000 1.000 

1202014000 12B Apricot, juice 4.000000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 4.000000 1.000 1.000 

1202230000 12B Nectarine 4.000000 1.000 1.000 

1202260000 12B Peach 4.000000 1.000 1.000 

1202260001 12B Peach-babyfood 4.000000 1.000 1.000 

1202261000 12B Peach, dried 4.000000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 4.000000 7.000 1.000 

1202262000 12B Peach, juice 4.000000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 4.000000 1.000 1.000 

1203285000 12C Plum 0.600000 1.000 1.000 

1203285001 12C Plum-babyfood 0.600000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.600000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.600000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.600000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.600000 5.000 1.000 

1203288000 12C Plum, prune, juice 0.600000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.600000 1.400 1.000 

1301055000 13A Blackberry 1.000000 1.000 1.000 

1301056000 13A Blackberry, juice 1.000000 1.000 1.000 

1301056001 13A Blackberry, juice-babyfood 1.000000 1.000 1.000 

1301058000 13A Boysenberry 1.000000 1.000 1.000 

1301208000 13A Loganberry 1.000000 1.000 1.000 

1301320000 13A Raspberry 1.000000 1.000 1.000 

1301320001 13A Raspberry-babyfood 1.000000 1.000 1.000 

1301321000 13A Raspberry, juice 1.000000 1.000 1.000 

1301321001 13A Raspberry, juice-babyfood 1.000000 1.000 1.000 

1302057000 13B Blueberry 1.300000 1.000 1.000 

1302057001 13B Blueberry-babyfood 1.300000 1.000 1.000 

1302136000 13B Currant 1.000000 1.000 1.000 

1302137000 13B Currant, dried 1.000000 1.000 1.000 

1302149000 13B Elderberry 1.000000 1.000 1.000 

1302174000 13B Gooseberry 1.000000 1.000 1.000 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 16 of 23 

1302191000 13B Huckleberry 1.000000 1.000 1.000 

1307130000 13G Cranberry 1.000000 1.000 1.000 

1307130001 13G Cranberry-babyfood 1.000000 1.000 1.000 

1307131000 13G Cranberry, dried 1.000000 1.000 1.000 

1307132000 13G Cranberry, juice 1.000000 1.000 1.000 

1307132001 13G Cranberry, juice-babyfood 1.000000 1.000 1.000 

1307359000 13G Strawberry 1.300000 1.000 1.000 

1307359001 13G Strawberry-babyfood 1.300000 1.000 1.000 

1307360000 13G Strawberry, juice 1.300000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 1.300000 1.000 1.000 

1400003000 14 Almond 0.100000 1.000 1.000 

1400003001 14 Almond-babyfood 0.100000 1.000 1.000 

1400004000 14 Almond, oil 0.100000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.100000 1.000 1.000 

1400059000 14 Brazil nut 0.100000 1.000 1.000 

1400068000 14 Butternut 0.100000 1.000 1.000 

1400081000 14 Cashew 0.100000 1.000 1.000 

1400092000 14 Chestnut 0.100000 1.000 1.000 

1400155000 14 Hazelnut 0.100000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 

1400185000 14 Hickory nut 0.100000 1.000 1.000 

1400213000 14 Macadamia nut 0.100000 1.000 1.000 

1400269000 14 Pecan 0.100000 1.000 1.000 

1400282000 14 Pistachio 0.100000 1.000 1.000 

1400391000 14 Walnut 0.100000 1.000 1.000 

1500025000 15 Barley, pearled barley 3.000000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 3.000000 1.000 1.000 

1500026000 15 Barley, flour 3.000000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 3.000000 1.000 1.000 

1500027000 15 Barley, bran 6.000000 1.000 1.000 

1500120000 15 Corn, field, flour 0.200000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.200000 1.000 1.000 

1500121000 15 Corn, field, meal 0.200000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.200000 1.000 1.000 

1500122000 15 Corn, field, bran 0.200000 1.000 1.000 

1500123000 15 Corn, field, starch 0.200000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.200000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.200000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.200000 1.500 1.000 

1500125000 15 Corn, field, oil 0.200000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.200000 1.000 1.000 

1500126000 15 Corn, pop 0.200000 1.000 1.000 

1500127000 15 Corn, sweet 0.100000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.100000 1.000 1.000 

1500231000 15 Oat, bran 6.000000 1.000 1.000 

1500232000 15 Oat, flour 3.000000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 3.000000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 3.000000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 3.000000 1.000 1.000 

1500323000 15 Rice, white 7.000000 1.000 1.000 

1500323001 15 Rice, white-babyfood 7.000000 1.000 1.000 

1500324000 15 Rice, brown 7.000000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 7.000000 1.000 1.000 

1500325000 15 Rice, flour 7.000000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 7.000000 1.000 1.000 

1500326000 15 Rice, bran 15.000000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 15.000000 1.000 1.000 

1500328000 15 Rye, grain 0.300000 1.000 1.000 

1500329000 15 Rye, flour 0.300000 1.000 1.000 

1500344000 15 Sorghum, grain 3.500000 1.000 1.000 

1500345000 15 Sorghum, syrup 3.500000 1.000 1.000 

1500401000 15 Wheat, grain 0.300000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.300000 1.000 1.000 

1500402000 15 Wheat, flour 0.300000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.300000 1.000 1.000 

1500403000 15 Wheat, germ 0.300000 1.000 1.000 

1500404000 15 Wheat, bran 0.600000 1.000 1.000 

1500405000 15 Wild rice 0.500000 1.000 1.000 

1901118000 19A Cilantro, leaves 13.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 13.000000 1.000 1.000 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 17 of 23 

1901249000 19A Parsley, dried leaves 35.000000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 35.000000 1.000 1.000 

2100228000 21 Mushroom 0.100000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

3100047000 31 Beef, fat 0.050000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 

3100048000 31 Beef, kidney 2.000000 1.000 1.000 

3100049000 31 Beef, liver 2.000000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 2.000000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 

3200171000 32 Goat, fat 0.050000 1.000 1.000 

3200172000 32 Goat, kidney 2.000000 1.000 1.000 

3200173000 32 Goat, liver 2.000000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400294000 34 Pork, kidney 0.200000 1.000 1.000 

3400295000 34 Pork, liver 0.200000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 

3500341000 35 Sheep, fat 0.050000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.000 

3500342000 35 Sheep, kidney 2.000000 1.000 1.000 

3500343000 35 Sheep, liver 2.000000 1.000 1.000 

3600222000 36 Milk, fat 0.050000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

3600224000 36 Milk, water 0.050000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.055780 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.055780 1.000 1.000 

9500020000 O Avocado 10.000000 1.000 1.000 

9500023000 O Banana 0.200000 1.000 1.000 

9500023001 O Banana-babyfood 0.200000 1.000 1.000 

9500024000 O Banana, dried 0.200000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.200000 3.900 1.000 

9500263000 O Peanut 0.200000 1.000 1.000 

9500264000 O Peanut, butter 0.200000 1.890 1.000 

9500265000 O Peanut, oil 0.200000 1.000 1.000 

9500275000 O Peppermint 10.000000 1.000 1.000 

9500276000 O Peppermint, oil 10.000000 1.000 1.000 

9500279000 O Pineapple 4.500000 1.000 1.000 

9500279001 O Pineapple-babyfood 4.500000 1.000 1.000 

9500280000 O Pineapple, dried 4.500000 5.000 1.000 

9500281000 O Pineapple, juice 4.500000 1.700 1.000 

9500281001 O Pineapple, juice-babyfood 4.500000 1.700 1.000 

9500283000 O Plantain 0.200000 1.000 1.000 

9500284000 O Plantain, dried 0.200000 3.900 1.000 

9500352000 O Spearmint 10.000000 1.000 1.000 

9500353000 O Spearmint, oil 10.000000 1.000 1.000 

9500362000 O Sugarcane, sugar 0.400000 1.000 1.000 

9500362001 O Sugarcane, sugar-babyfood 0.400000 1.000 1.000 

9500363000 O Sugarcane, molasses 0.400000 1.000 1.000 

9500363001 O Sugarcane, molasses-babyfood 0.400000 1.000 1.000 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 18 of 23 

Attachment 2. Acute Results file. 

U.S. EPA Ver. 3.16, 03-08-d 

DEEM-FCID ACUTE Analysis for PROPICONAZOLE NHANES 2003-2008 2-Day 

Residue file: 122101 Acute 2F7975 Oct 2012.R08 Adjustment factor #2 NOT used. 

Analysis Date: 10-16-2012/13:49:34 Residue file dated: 10-16-2012/13:48:00 

RAC/FF intake summed over 24 hours 

Run Comment: "" 

=============================================================================== 

Summary calculations--per capita: 

 95th Percentile 99th Percentile 99.9th Percentile 

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- -------- 

Total US Population: 

 0.077562 25.85 0.159619 53.21 0.377394 125.80 

All Infants: 

 0.108099 36.03 0.187782 62.59 0.351549 117.18 

Children 1-2: 

 0.253533 84.51 0.432596 144.20 0.762949 254.32 

Children 3-5: 

 0.194271 64.76 0.353578 117.86 0.508278 169.43 

Children 6-12: 

 0.106036 35.35 0.192413 64.14 0.418507 139.50 

Youth 13-19: 

 0.073595 24.53 0.126481 42.16 0.195937 65.31 

Adults 20-49: 

 0.061233 20.41 0.100175 33.39 0.186014 62.00 

Adults 50-99: 

 0.050898 16.97 0.086386 28.80 0.157281 52.43 

Female 13-49: 

 0.060552 20.18 0.100742 33.58 0.165680 55.23 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 19 of 23 

Attachment 3. Chronic Food plus Water Residue Input file. 

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\122101 

Propiconazole\Petition 2F7975 Cereal Grains\122101 Chronic 2F7975 Avg FT for Aggregate 

Oct 2012.R08 

Chemical: Propiconazole 

RfD(Chronic): .1 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .3 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 10-16-2012/13:16:50 Program ver. 3.16, 03-08-d 

----------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ ------- 

0101050000 1AB Beet, garden, roots 0.120000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.120000 1.000 1.000 

0101052000 1A Beet, sugar 0.120000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.120000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 1.500000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 1.500000 1.000 1.000 

0101078000 1AB Carrot 0.100000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.100000 1.000 1.000 

0101079000 1AB Carrot, juice 0.100000 1.000 1.000 

0200051000 2 Beet, garden, tops 5.500000 1.000 1.000 

0301165000 3A Garlic, bulb 0.200000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.200000 1.000 1.000 

0301237000 3A Onion, bulb 0.200000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.200000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.200000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.200000 9.000 1.000 

0302198000 3B Leek 2.430000 1.000 1.000 

0302239000 3B Onion, green 2.430000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 0.200000 1.000 1.000 

0401248000 4A Parsley, leaves 3.650000 1.000 1.000 

0402076000 4B Cardoon 1.010000 1.000 1.000 

0402085000 4B Celery 1.010000 1.000 1.000 

0402085001 4B Celery-babyfood 1.010000 1.000 1.000 

0402086000 4B Celery, juice 1.010000 1.000 1.000 

0402087000 4B Celtuce 1.010000 1.000 1.000 

0402152000 4B Fennel, Florence 1.010000 1.000 1.000 

0402322000 4B Rhubarb 1.010000 1.000 1.000 

0402367000 4B Swiss chard 1.010000 1.000 1.000 

0600347000 6 Soybean, seed 0.260000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.260000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.260000 1.000 1.000 

0600350000 6 Soybean, oil 0.260000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.260000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.700000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.700000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.260000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.100000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.100000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.100000 1.000 1.000 

0603030000 6C Bean, black, seed 0.400000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.400000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.400000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.400000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.400000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.400000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.400000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.400000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.400000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.400000 1.000 1.000 

0603098000 6C Chickpea, seed 0.400000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.400000 1.000 1.000 

0603099000 6C Chickpea, flour 0.400000 1.000 1.000 

0603182000 6C Guar, seed 0.400000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.400000 1.000 1.000 

0603203000 6C Lentil, seed 0.400000 1.000 1.000 

0603348000 6C Soybean, flour 0.260000 1.000 1.000 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 20 of 23 

0603348001 6C Soybean, flour-babyfood 0.260000 1.000 1.000 

0801374000 8A Tomatillo 0.791000 1.000 1.000 

0801375000 8A Tomato 0.791000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.791000 1.000 1.000 

0801376000 8A Tomato, paste 0.791000 5.400 1.000 

0801376001 8A Tomato, paste-babyfood 0.791000 5.400 1.000 

0801377000 8A Tomato, puree 0.791000 3.300 1.000 

0801377001 8A Tomato, puree-babyfood 0.791000 3.300 1.000 

0801378000 8A Tomato, dried 0.791000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.791000 14.300 1.000 

0801379000 8A Tomato, juice 0.791000 1.500 1.000 

1001106000 10A Citron 2.340000 1.000 1.000 

1001107000 10A Citrus hybrids 2.340000 1.000 1.000 

1001108000 10A Citrus, oil 1000. 1.000 1.000 

1001240000 10A Orange 2.340000 1.000 1.000 

1001241000 10A Orange, juice 2.340000 1.000 1.000 

1001241001 10A Orange, juice-babyfood 2.340000 1.000 1.000 

1001242000 10A Orange, peel 2.340000 1.000 1.000 

1001369000 10A Tangerine 2.340000 1.000 1.000 

1001370000 10A Tangerine, juice 2.340000 1.000 1.000 

1002197000 10B Kumquat 2.340000 1.000 1.000 

1002199000 10B Lemon 1.790000 1.000 1.000 

1002200000 10B Lemon, juice 1.790000 1.000 1.000 

1002200001 10B Lemon, juice-babyfood 1.790000 1.000 1.000 

1002201000 10B Lemon, peel 1.790000 1.000 1.000 

1002206000 10B Lime 2.340000 1.000 1.000 

1002207000 10B Lime, juice 2.340000 1.000 1.000 

1002207001 10B Lime, juice-babyfood 2.340000 1.000 1.000 

1003180000 10C Grapefruit 1.180000 1.000 1.000 

1003181000 10C Grapefruit, juice 1.180000 1.000 1.000 

1003307000 10C Pummelo 2.340000 1.000 1.000 

1201090000 12A Cherry 0.563000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.563000 1.000 1.000 

1201091000 12A Cherry, juice 0.563000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.563000 1.500 1.000 

1202012000 12B Apricot 0.961000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.961000 1.000 1.000 

1202013000 12B Apricot, dried 0.961000 6.000 1.000 

1202014000 12B Apricot, juice 0.961000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.961000 1.000 1.000 

1202230000 12B Nectarine 0.961000 1.000 1.000 

1202260000 12B Peach 0.961000 1.000 1.000 

1202260001 12B Peach-babyfood 0.961000 1.000 1.000 

1202261000 12B Peach, dried 0.961000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.961000 7.000 1.000 

1202262000 12B Peach, juice 0.961000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.961000 1.000 1.000 

1203285000 12C Plum 0.183000 1.000 1.000 

1203285001 12C Plum-babyfood 0.183000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.183000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.183000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.183000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.183000 5.000 1.000 

1203288000 12C Plum, prune, juice 0.183000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.183000 1.400 1.000 

1301055000 13A Blackberry 0.360000 1.000 1.000 

1301056000 13A Blackberry, juice 0.360000 1.000 1.000 

1301056001 13A Blackberry, juice-babyfood 0.360000 1.000 1.000 

1301058000 13A Boysenberry 0.360000 1.000 1.000 

1301208000 13A Loganberry 0.360000 1.000 1.000 

1301320000 13A Raspberry 0.360000 1.000 1.000 

1301320001 13A Raspberry-babyfood 0.360000 1.000 1.000 

1301321000 13A Raspberry, juice 0.360000 1.000 1.000 

1301321001 13A Raspberry, juice-babyfood 0.360000 1.000 1.000 

1302057000 13B Blueberry 0.350000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.350000 1.000 1.000 

1302136000 13B Currant 0.360000 1.000 1.000 

1302137000 13B Currant, dried 0.360000 1.000 1.000 

1302149000 13B Elderberry 0.360000 1.000 1.000 

1302174000 13B Gooseberry 0.360000 1.000 1.000 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 21 of 23 

1302191000 13B Huckleberry 0.360000 1.000 1.000 

1307130000 13G Cranberry 0.320000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.320000 1.000 1.000 

1307131000 13G Cranberry, dried 0.320000 1.000 1.000 

1307132000 13G Cranberry, juice 0.320000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.320000 1.100 1.000 

1307359000 13G Strawberry 0.350000 1.000 1.000 

1307359001 13G Strawberry-babyfood 0.350000 1.000 1.000 

1307360000 13G Strawberry, juice 0.350000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 0.350000 1.000 1.000 

1400003000 14 Almond 0.038000 1.000 1.000 

1400003001 14 Almond-babyfood 0.038000 1.000 1.000 

1400004000 14 Almond, oil 0.038000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.038000 1.000 1.000 

1400059000 14 Brazil nut 0.100000 1.000 1.000 

1400068000 14 Butternut 0.100000 1.000 1.000 

1400081000 14 Cashew 0.100000 1.000 1.000 

1400092000 14 Chestnut 0.100000 1.000 1.000 

1400155000 14 Hazelnut 0.100000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 

1400185000 14 Hickory nut 0.100000 1.000 1.000 

1400213000 14 Macadamia nut 0.100000 1.000 1.000 

1400269000 14 Pecan 0.100000 1.000 1.000 

1400282000 14 Pistachio 0.100000 1.000 1.000 

1400391000 14 Walnut 0.100000 1.000 1.000 

1500025000 15 Barley, pearled barley 3.000000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 3.000000 1.000 1.000 

1500026000 15 Barley, flour 3.000000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 3.000000 1.000 1.000 

1500027000 15 Barley, bran 6.000000 1.000 1.000 

1500120000 15 Corn, field, flour 0.036000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.036000 1.000 1.000 

1500121000 15 Corn, field, meal 0.036000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.036000 1.000 1.000 

1500122000 15 Corn, field, bran 0.036000 1.000 1.000 

1500123000 15 Corn, field, starch 0.036000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.036000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.036000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.036000 1.500 1.000 

1500125000 15 Corn, field, oil 0.036000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.036000 1.000 1.000 

1500126000 15 Corn, pop 0.036000 1.000 1.000 

1500127000 15 Corn, sweet 0.100000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.100000 1.000 1.000 

1500231000 15 Oat, bran 6.000000 1.000 1.000 

1500232000 15 Oat, flour 3.000000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 3.000000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 3.000000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 3.000000 1.000 1.000 

1500323000 15 Rice, white 1.490000 1.000 1.000 

1500323001 15 Rice, white-babyfood 1.490000 1.000 1.000 

1500324000 15 Rice, brown 1.490000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 1.490000 1.000 1.000 

1500325000 15 Rice, flour 1.490000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 1.490000 1.000 1.000 

1500326000 15 Rice, bran 15.000000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 15.000000 1.000 1.000 

1500328000 15 Rye, grain 0.300000 1.000 1.000 

1500329000 15 Rye, flour 0.300000 1.000 1.000 

1500344000 15 Sorghum, grain 1.270000 1.000 1.000 

1500345000 15 Sorghum, syrup 1.270000 1.000 1.000 

1500401000 15 Wheat, grain 0.043000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.043000 1.000 1.000 

1500402000 15 Wheat, flour 0.043000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.043000 1.000 1.000 

1500403000 15 Wheat, germ 0.043000 1.000 1.000 

1500404000 15 Wheat, bran 0.600000 1.000 1.000 

1500405000 15 Wild rice 0.500000 1.000 1.000 

1901118000 19A Cilantro, leaves 13.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 13.000000 1.000 1.000 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 22 of 23 

1901249000 19A Parsley, dried leaves 35.000000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 35.000000 1.000 1.000 

2100228000 21 Mushroom 0.100000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

3100047000 31 Beef, fat 0.050000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 

3100048000 31 Beef, kidney 2.000000 1.000 1.000 

3100049000 31 Beef, liver 2.000000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 2.000000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 

3200171000 32 Goat, fat 0.050000 1.000 1.000 

3200172000 32 Goat, kidney 2.000000 1.000 1.000 

3200173000 32 Goat, liver 2.000000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400294000 34 Pork, kidney 0.200000 1.000 1.000 

3400295000 34 Pork, liver 0.200000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 

3500341000 35 Sheep, fat 0.050000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.000 

3500342000 35 Sheep, kidney 2.000000 1.000 1.000 

3500343000 35 Sheep, liver 2.000000 1.000 1.000 

3600222000 36 Milk, fat 0.050000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

3600224000 36 Milk, water 0.050000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.021610 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.021610 1.000 1.000 

9500020000 O Avocado 10.000000 1.000 1.000 

9500023000 O Banana 0.200000 1.000 1.000 

9500023001 O Banana-babyfood 0.200000 1.000 1.000 

9500024000 O Banana, dried 0.200000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.200000 3.900 1.000 

9500263000 O Peanut 0.200000 1.000 1.000 

9500264000 O Peanut, butter 0.200000 1.890 1.000 

9500265000 O Peanut, oil 0.200000 1.000 1.000 

9500275000 O Peppermint 10.000000 1.000 1.000 

9500276000 O Peppermint, oil 10.000000 1.000 1.000 

9500279000 O Pineapple 1.030000 1.000 1.000 

9500279001 O Pineapple-babyfood 1.030000 1.000 1.000 

9500280000 O Pineapple, dried 1.030000 5.000 1.000 

9500281000 O Pineapple, juice 1.030000 1.000 1.000 

9500281001 O Pineapple, juice-babyfood 1.030000 1.000 1.000 

9500283000 O Plantain 0.200000 1.000 1.000 

9500284000 O Plantain, dried 0.200000 3.900 1.000 

9500352000 O Spearmint 10.000000 1.000 1.000 

9500353000 O Spearmint, oil 10.000000 1.000 1.000 

9500362000 O Sugarcane, sugar 0.120000 1.000 1.000 

9500362001 O Sugarcane, sugar-babyfood 0.120000 1.000 1.000 

9500363000 O Sugarcane, molasses 0.120000 1.000 1.000 

9500363001 O Sugarcane, molasses-babyfood 0.120000 1.000 1.000 
 Propiconazole Dietary Exposure and Risk Assessment DP Number: D403630 

PC Code: 122101 

______________________________________________________________________________________

Page 23 of 23 

Attachment 4. Chronic Results file.

U.S. EPA Ver. 3.16, 03-08-d 

DEEM-FCID Chronic analysis for PROPICONAZOLE NHANES 2003-2008 2-day 

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM 

Files\122101 Propiconazole\Petition 2F7975 Cereal Grains\122101 Chronic 2F7975 Avg FT 

for Aggregate Oct 2012.R08 

 Adjustment factor #2 used. 

Analysis Date 10-16-2012/13:35:01 Residue file dated: 10-16-2012/13:16:50 

Reference dose (RfD, Chronic) = .1 mg/kg bw/day 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------- 

Total US Population 0.007432 7.4% 

Hispanic 0.010068 10.1% 

Non-Hisp-White 0.006795 6.8% 

Non-Hisp-Black 0.007584 7.6% 

Non-Hisp-Other 0.008731 8.7% 

Nursing Infants 0.006637 6.6% 

Non-Nursing Infants 0.011907 11.9% 

Female 13+ PREG 0.008189 8.2% 

Children 1-6 0.019909 19.9% 

Children 7-12 0.009218 9.2% 

Male 13-19 0.006517 6.5% 

Female 13-19/NP 0.005548 5.5% 

Male 20+ 0.006314 6.3% 

Female 20+/NP 0.005523 5.5% 

Seniors 55+ 0.005521 5.5% 

All Infants 0.010280 10.3% 

Female 13-50 0.005651 5.7% 

Children 1-2 0.023718 23.7% 

Children 3-5 0.019121 19.1% 

Children 6-12 0.009941 9.9% 

Youth 13-19 0.006022 6.0% 

Adults 20-49 0.006180 6.2% 

Adults 50-99 0.005618 5.6% 

Female 13-49 0.005622 5.6% 

-------------------------------------------------------------------------------