[Federal Register Volume 65, Number 211 (Tuesday, October 31, 2000)]
[Notices]
[Pages 65234-65240]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 00-27926]



[[Page 65233]]

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Part IV





Environmental Protection Agency





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Forty-Third Report of the TSCA Interagency Testing Committee; Notice

Federal Register / Vol. 65, No. 211 / Tuesday, October 31, 2000 / 
Notices

[[Page 65234]]


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ENVIRONMENTAL PROTECTION AGENCY

[OPPTS-41051; FRL-6049-5]


Forty-Third Report of the TSCA Interagency Testing Committee to 
the Administrator; Receipt of Report and Request for Comments

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The Toxic Substances Control Act (TSCA) Interagency Testing 
Committee (ITC) transmitted its Forty-Third Report to the Administrator 
of the EPA on November 19, 1998. In the 43<SUP>rd</SUP> Report, which 
is included with this notice, the ITC revised the TSCA section 4(e) 
Priority Testing List by removing 9 High Production Volume Chemicals 
(HPVCs), 7 alkylphenols, and 2 octylphenol ethoxylates. The ITC is also 
asking EPA to promulgate a TSCA section (d) reporting rule for 18 
alkylphenols; 15 nonylphenol ethoxylates; 3-amino-5-mercapto-1,2,4-
triazole; glycoluril; and methylal recommended by the ITC for testing 
in several previous ITC Reports. There are no recommended, designated, 
or recommended with intent-to-designate chemicals or chemical groups in 
the 43<SUP>rd</SUP> Report. EPA invites interested persons to submit 
written comments on the Report.

DATES: Comments, identified by docket control number OPPTS-41051, must 
be received on or before November 30, 2000.

ADDRESSES: Comments may be submitted by mail, electronically, or in 
person. Please follow the detailed instructions for each method as 
provided in Unit I. of the SUPPLEMENTARY INFORMATION. To ensure proper 
receipt by EPA, it is imperative that you identify docket control 
number OPPTS-41051 in the subject line on the first page of your 
response.

FOR FURTHER INFORMATION CONTACT: For general information contact: 
Barbara Cunningham, Acting Director, Environmental Assistance Division, 
Office of Pollution Prevention and Toxics (7408), Environmental 
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460; 
telephone number: (202) 554-1404; e-mail address: <a href="/cdn-cgi/l/email-protection#3d696e7e7c10755249515453587d584d5c135a524b"><span class="__cf_email__" data-cfemail="b9edeafaf894f1d6cdd5d0d7dcf9dcc9d897ded6cf">[email protected]</span></a>.
    For technical information contact: John D. Walker, ITC Executive 
Director (7401), Environmental Protection Agency, 1200 Pennsylvania 
Ave., NW., Washington, DC 20460; telephone number: (202) 260-1825; fax: 
(202) 260-7895; e-mail address: 
<a href="/cdn-cgi/l/email-protection#384f5954535d4a16525750565c785d4859165f574e"><span class="__cf_email__" data-cfemail="245345484f41560a4e4b4c4a40644154450a434b52">[email protected]</span></a>.

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this Action Apply to Me?

    This action is directed to the public in general. It may, however, 
be of particular interest to you if you manufacture (defined by statute 
to include import) any of the chemicals listed and you may be 
identified by the North American Industrial Classification System 
(NAICS) codes 325 and 32411. Because this action is directed to the 
general public and other entities may also be interested, the Agency 
has not attempted to describe all the specific entities that may be 
interested in this action. If you have any questions regarding the 
applicability of this action to a particular entity, consult the person 
listed under FOR FURTHER INFORMATION CONTACT.

B. How Can I Get Additional Information, Including Copies of this 
Document or Other Related Documents?

    1. Electronically. You may obtain electronic copies of this 
document, and certain other related documents that might be available 
electronically, from the EPA Internet Home Page at http://www.epa.gov/. 
To access this document, on the Home Page select ``Laws and 
Regulations,'' ``Regulations and Proposed Rules,'' and then look up the 
entry for this document under the ``Federal Register--Environmental 
Documents.'' You can also go directly to the Federal Register listings 
at http://www.epa.gov/fedrgstr/.
    You may also access additional information about the ITC and the 
TSCA testing program through the web site for the Office of Prevention, 
Pesticides and Toxic Substances (OPPTS) at http://www.epa.gov/internet/oppts/, or go directly to the ITC Home Page at http://www.epa.gov/opptintr/itc/.
    2. In person. The Agency has established an official record for 
this action under docket control number OPPTS-41051. The official 
record consists of the documents specifically referenced in this 
action, any public comments received during an applicable comment 
period, and other information related to this action, including any 
information claimed as Confidential Business Information (CBI). This 
official record includes the documents that are physically located in 
the docket, as well as the documents that are referenced in those 
documents. The public version of the official record does not include 
any information claimed as CBI. The public version of the official 
record, which includes printed, paper versions of any electronic 
comments submitted during an applicable comment period, is available 
for inspection in the TSCA Nonconfidential Information Center, North 
East Mall Rm. B-607, Waterside Mall, 401 M St., SW., Washington, DC. 
The Center is open from noon to 4 p.m., Monday through Friday, 
excluding legal holidays. The telephone number for the Center is (202) 
260-7099.

C. How and to Whom Do I Submit Comments?

    You may submit comments through the mail, in person, or 
electronically. To ensure proper receipt by EPA, it is imperative that 
you identify docket control number OPPTS-41051 in the subject line on 
the first page of your response.
    1. By mail. Submit your comments to: Document Control Office 
(7407), Office of Pollution Prevention and Toxics (OPPT), Environmental 
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460.
    2. In person or by courier. Deliver your comments to: OPPT Document 
Control Office (DCO) in East Tower Rm. G-099, Waterside Mall, 401 M 
St., SW., Washington, DC. The DCO is open from 8 a.m. to 4 p.m., Monday 
through Friday, excluding legal holidays. The telephone number for the 
DCO is (202) 260-7093.
    3. Electronically. You may submit your comments electronically by 
e-mail to: <a href="/cdn-cgi/l/email-protection#aec1dededa80c0cdc7cdeecbdecf80c9c1d8"><span class="__cf_email__" data-cfemail="56392626227838353f351633263778313920">[email protected]</span></a>, or mail your computer disk to the address 
identified above. Do not submit any information electronically that you 
consider to be CBI. Electronic comments must be submitted as an ASCII 
file avoiding the use of special characters and any form of encryption. 
Comments and data will also be accepted on standard disks in 
WordPerfect 6.1/8 or ASCII file format. All comments in electronic form 
must be identified by docket control number OPPTS-41051. Electronic 
comments may also be filed online at many Federal Depository Libraries.

D. How Should I Handle CBI Information That I Want to Submit to the 
Agency?

    Do not submit any information electronically that you consider to 
be CBI. You may claim information that you submit to EPA in response to 
this document as CBI by marking any part or all of that information as 
CBI. Information so marked will not be disclosed except in accordance 
with procedures set forth in 40 CFR part 2. In addition to one complete 
version of the comment that includes any information claimed as CBI, a 
copy of

[[Page 65235]]

the comment that does not contain the information claimed as CBI must 
be submitted for inclusion in the public version of the official 
record. Information not marked confidential will be included in the 
public version of the official record without prior notice. If you have 
any questions about CBI or the procedures for claiming CBI, please 
consult the technical person listed under FOR FURTHER INFORMATION 
CONTACT.

E. What Should I Consider as I Prepare My Comments for EPA?

    We invite you to provide your views and comments on the ITC's 43rd 
Report. You may find the following suggestions helpful for preparing 
your comments:
    1. Explain your views as clearly as possible.
    2. Describe any assumptions that you used.
    3. Provide copies of any technical information and/or data you used 
that support your views.
    4. Provide specific examples to illustrate your concerns.
    5. Make sure to submit your comments by the deadline in this 
notice.
    6. To ensure proper receipt by EPA, be sure to identify the docket 
control number OPPTS-41051 in the subject line on the first page of 
your response. You may also provide the name, date, and Federal 
Register citation.

II. Background

    The Toxic Substances Control Act (TSCA) (15 U.S.C. 2601 et seq.) 
authorizes the Administrator of the EPA to promulgate regulations under 
section 4(a) requiring testing of chemicals and chemical groups in 
order to develop data relevant to determining the risks that such 
chemicals and chemical groups may present to health or the environment. 
Section 4(e) of TSCA established the ITC to recommend chemicals and 
chemical groups to the Administrator of the EPA for priority testing 
consideration. Section 4(e) of TSCA directs the ITC to revise the TSCA 
section 4(e) Priority Testing List at least every 6 months.
    EPA has received the TSCA ITC's 43rd Report to the Administrator. 
The most recent revisions to the Priority Testing List are included in 
the ITC's 43rd Report. The Report was received by the EPA Administrator 
on November 19, 1998, and is included in this notice. The ITC revised 
the TSCA section 4(e) Priority Testing List by removing 9 HPVCs that 
were recommended in the 36th Report (60 FR 42982, August 17, 1995) 
(FRL-4965-6) and 7 alkylphenols and 2 octylphenol ethoxylates that were 
recommended in the 37th Report (61 FR 4188, February 2, 1996) (FRL-
4991-6).
    The ITC is also asking EPA to promulgate a TSCA section 8(d) 
reporting rule for 15 nonylphenol ethoxylates that were recommended in 
the 39th Report (62 FR 8578, February 25, 1997) (FRL-5580-9), 18 
alkylphenols that were recommended in the 41st Report (63 FR 17658, 
April 8, 1998) (FRL-5773-5), and 3-amino-5-mercapto-1,2,4-triazole; 
glycoluril; and methylal that were recommended in the 42nd Report (63 
FR 42553, August 7, 1998) (FRL-5797-8) to determine if there are 
unpublished data to meet previously determined U.S. Government data 
needs.
    1. Promulgation of a TSCA section 8(d) reporting rule. The ITC's 
Voluntary Information Submissions Innovative Online Network (VISION) is 
accessible through the world wide web (http://www.epa.gov/opptintr/itc/vision.htm) and is designed to promote more efficient use of TSCA 
section 8 resources through submission of electronic information. As 
part of VISION, the Voluntary Information Submission Policy clearly 
states that if the ITC does not receive voluntary electronic 
information submissions to meet the data needs for recommended 
chemicals, then it will ask the EPA to promulgate a TSCA section 8(d) 
reporting rule to determine if there are unpublished studies to meet 
those data needs. The EPA is being asked to promulgate a TSCA section 
8(d) reporting rule for the chemicals referenced in this unit, because 
studies submitted to the VISION did not adequately meet the data needs 
for those chemicals. The ITC is requesting that the EPA promulgate a 
TSCA section 8(d) reporting rule to meet only those data needs listed 
in certain previous ITC Reports.
    2. Data needs--i. Nonylphenol ethoxylates and alkylphenols. Data 
needs for 15 nonylphenol ethoxylates recommended in the 39th ITC Report 
and 18 alkylphenols recommended in the 41st ITC Report are identical 
and are listed in this unit as they were expressed in the 41st ITC 
Report:
    a. Fish and amphibian multi-generation reproductive effects data.
    b. Avian acute toxicity data (oral feeding and egg exposure 
studies).
    c. Avian reproductive effects data.
    d. Fish and wildlife studies data.
    e. Bioaccumulation or bioavailability data.
    f. Health effects data, including absorption, toxicokinetics, 
systemic toxicity, endocrine disruption, reproductive effects, and 
carcinogenicity data.
    ii. 3-Amino-5-mercapto-1,2,4-triazole. Data needs for 3-amino-5-
mercapto-1,2,4-triazole are listed in this unit as they were expressed 
in the 42nd ITC Report: Health effects.
    iii. Glycoluril. Data needs for glycoluril are listed in this unit 
as they were expressed in the 42nd Report: Health effects.
    iv. Methylal. Data needs for methylal are listed in this unit as 
they were expressed in the 42nd Report: Health effects, especially, in 
vivo mammalian metabolism and chronic effects.
    3. Status of the Priority Testing List. The TSCA section 4(e) 
Priority Testing List as of November 1998 can be found in Table 1 of 
the 43rd ITC Report which is included in this notice.

List of Subjects

    Environmental protection, Chemicals, Hazardous substances.

    Dated: October 24, 2000.
Charles M. Auer,
Director, Chemical Control Division, Office of Pollution Prevention and 
Toxics.

Forty-Third Report of the TSCA Interagency Testing Committee to the 
Administrator, U.S. Environmental Protection Agency

Table of Contents

Summary

I. Background
II. TSCA Section 8 Reporting
    A. TSCA Section 8 Rules
    B. ITC's Use of TSCA Section 8 and ``Other Information''
    C. Promoting More Efficient Use of Information Submission 
Resources
    D. Request to Promulgate a TSCA Section 8(d) Rule
    E. Chemicals for Which the ITC is Requesting That EPA Promulgate 
a TSCA Section 8(d) Rule
III. ITC's Dialogue Group Activities During This Reporting Period 
(May to November 1998)
IV. Revisions to the TSCA Section 4(e) Priority Testing List
    A. Summary Table of Changes
    B. Chemicals Removed From the Priority Testing List
    V. TSCA Interagency Testing Committee

Summary

    This is the 43rd Report of the TSCA Interagency Testing Committee 
(ITC) to the Administrator of the U.S. Environmental Protection Agency 
(EPA). In this Report, the ITC is revising its TSCA section 4(e) 
Priority Testing List by removing 9 High Production Volume Chemicals 
(HPVCs), 7 alkylphenols, and 2 octylphenol ethoxylates. In this Report, 
the ITC is also asking EPA to promulgate a TSCA section 8(d) Health and 
Safety Data Reporting (HaSD) rule for 18

[[Page 65236]]

alkylphenols, 15 nonylphenol ethoxylates, 3-amino-5-mercapto-1,2,4-
triazole, glycoluril, and methylal to determine if there are 
unpublished data to meet previously determined U.S. Government data 
needs. The revised TSCA section 4(e) Priority Testing List follows as 
Table 1.

                    Table 1.--The TSCA Section 4(e) Priority Testing List (November 1998) \1\
----------------------------------------------------------------------------------------------------------------
                Report                           Date                Chemical/Group               Action
----------------------------------------------------------------------------------------------------------------
26...................................  May 1990...............  8 Isocyanates..........  Recommended with intent-
                                                                                          to-designate
27...................................  November 1990..........  62 Aldehydes...........  Recommended with intent-
                                                                                          to-designate
28...................................  May 1991...............  Chemicals with Low       Designated
                                                                 Confidence Reference
                                                                 Dose (RfD).
                                                                  Acetone..............
                                                                  Thiophenol...........
30...................................  May 1992...............  5 Siloxanes............  Recommended
31...................................  January 1993...........  24 Chemicals with        Designated
                                                                 insufficient dermal
                                                                 absorption rate data.
32...................................  May 1993...............  32 Chemicals with        Designated
                                                                 insufficient dermal
                                                                 absorption rate data.
35...................................  November 1994..........  24 Chemicals with        Designated
                                                                 insufficient dermal
                                                                 absorption rate data.
37...................................  November 1995..........  16 Alkylphenols and 3    Recommended
                                                                 alkylphenol
                                                                 polyethoxylates.
39...................................  November 1996..........  15 Nonylphenol           Recommended
                                                                 ethoxylates and 8
                                                                 alkylphenol
                                                                 polyethoxylates.
41...................................  November 1997..........  18 Alkylphenols, 5       Recommended
                                                                 polyalkyphenols, and 6
                                                                 alkylphenol
                                                                 polyethoxylates.
42...................................  May 1998...............  3-Amino-5-mercapto-      Recommended
                                                                 1,2,4-triazole.
42...................................  May 1998...............  Glycoluril.............  Recommended
42...................................  May 1998...............  Methylal...............  Recommended
42...................................  May 1998...............  Ethyl silicate\2\......  Recommended
----------------------------------------------------------------------------------------------------------------
\1\ The Priority Testing List is available from the ITC's web site (http://www.epa.gov/opptintr/itc).
\2\ Data requested through the ITC's Voluntary Information Submissions Innovative Online Network (VISION) (see
  http://www.epa.gov/opptintr/itc/vision.htm).

I. Background

    The ITC was established by section 4(e) of the Toxic Substances 
Control Act (TSCA) ``to make recommendations to the Administrator 
respecting the chemical substances and mixtures to which the 
Administrator should give priority consideration for the promulgation 
of a rule for testing under section 4(a).... At least every six 
months..., the Committee shall make such revisions to the Priority 
Testing List as it determines to be necessary and transmit them to the 
Administrator together with the Committee's reasons for the revisions'' 
(Public Law 94-469, 90 Stat. 2003 et seq. (15 U.S.C. 2601 et seq.)). 
Since its creation in 1976, the ITC has submitted 42 semi-annual (May 
and November) Reports to the EPA Administrator transmitting the 
Priority Testing List and its revisions. In 1989, the ITC began 
recommending chemical substances for information reporting, screening, 
and testing to meet the data needs of its member U.S. Government 
organizations. ITC Reports are available from http://www.epa.gov/opptintr/itc/ within a few days of submission to the Administrator and 
from http://www.epa.gov/fedrgstr/ after publication in the Federal 
Register. The ITC meets monthly and produces its revisions to the List 
with administrative and technical support from the ITC staff and 
contract support provided by EPA. ITC members and staff are listed at 
the end of this Report.

II. TSCA Section 8 Reporting

A. TSCA Section 8 Rules

    Following receipt of the ITC's Report by the EPA Administrator and 
addition of chemicals to the Priority Testing List, the EPA's Office of 
Pollution Prevention and Toxics (OPPT) promulgates TSCA section 8(a) 
Preliminary Assessment Information Reporting (PAIR) and TSCA section 
8(d) HaSD Reporting rules for chemicals added to the Priority Testing 
List. These rules require producers and importers of chemicals 
recommended by the ITC to submit production and exposure reports under 
TSCA section 8(a) and producers, importers, and processors of chemicals 
recommended by the ITC to submit unpublished health and safety studies 
under TSCA section 8(d). These rules are automatically promulgated by 
OPPT unless requested not to do so by the ITC.

B. ITC's Use of TSCA Section 8 and ``Other Information''

    The ITC reviews the TSCA section 8(a) PAIR reports, TSCA section 
8(d) HaSD studies, and ``other information'' that becomes available 
after the ITC adds chemicals to the Priority Testing List. ``Other 
information'' includes TSCA section 4(a) and 4(d) studies, TSCA section 
8(c) submissions, TSCA section 8(e) ``substantial risk'' notices, ``For 
Your Information'' (FYI) submissions, ITC voluntary submissions, 
unpublished data submitted to U.S. Government organizations represented 
on the ITC, published papers, as well as use, exposure, effects, and 
persistence data that are voluntarily submitted to the ITC by 
manufacturers, importers, processors, and users of chemicals 
recommended by the ITC. The ITC reviews this information and determines 
if data needs should be revised, if chemicals should be removed from 
the Priority Testing List or if recommendations should be changed to 
designations.

C. Promoting More Efficient Use of Information Submission Resources

    The Voluntary Information Submissions Innovative Online Network 
(VISION) is accessible through the world wide web (http://www.epa.gov/opptintr/itc/vision.htm). VISION is the vehicle that is used to promote 
more efficient use of resources through submission of electronic 
information. VISION currently includes the Voluntary Information 
Submissions Policy (VISP), links to the TSCA Electronic HaSD Reporting 
Form 
(http://cyber22.dcoirm.epa.gov/oppt/

[[Page 65237]]

tsca.nsf/HaSDForm?openform) and instructions for the Form (http://www.epa.gov/opptintr/itc/tsca-hlp.htm). The VISP provides examples of 
data needed by ITC member U.S. Government organizations, examples of 
studies that should not be submitted, the 60-, 90-, and 120-day 
milestones for meeting the objectives of the VISP, guidelines for using 
the TSCA Electronic HaSD Reporting Form, and instructions for 
electronically submitting full studies. The TSCA Electronic HaSD 
Reporting Form is used to provide electronic information on ITC and 
TSCA section 8(d) studies (to meet data needs of the ITC member U.S. 
Government organizations), FYI, and TSCA section 8(e) studies, and 
studies to meet the needs of the HPV Chemical Challenge Program (http://www.epa.gov/opptintr/chemtest/hpv.htm).

D. Request to Promulgate a TSCA Section 8(d) Rule

    The ITC encourages producers, importers, processors, and users of 
its recommended chemicals to use VISION to voluntarily provide 
electronic information and establish a dialogue with the ITC to discuss 
needed data. As part of VISION, the VISP clearly states that if the ITC 
does not receive voluntary electronic information submissions to meet 
its data needs, then it will ask the EPA to promulgate a TSCA section 
8(d) HaSD rule to determine if there are unpublished data to meet those 
needs. As noted in Unit 2.C. of this Report, the TSCA Electronic HaSD 
Reporting Form is used to provide electronic information on TSCA 
section 8(d) studies. The ITC strongly encourages those companies that 
must respond to a TSCA section 8(d) rule to provide only the data 
requested by the ITC and to provide data by using the TSCA Electronic 
HaSD Reporting Form. At this time, the ITC is requesting that the EPA 
promulgate a TSCA section 8(d) rule for several chemicals with the 
understanding that submissions that were voluntarily provided as ITC 
submissions, do not have to be re-submitted under the TSCA section 8(d) 
HaSD rule. The ITC is requesting that the EPA promulgate a TSCA section 
8(d) HaSD rule to meet only those data needs listed in previous ITC 
Reports.

E. Chemicals for Which the ITC is Requesting That EPA Promulgate a TSCA 
Section 8(d) Rule

    1. 39th and 41st Report chemicals. The ITC considered structures 
and annual production and importation volumes for nonylphenol 
ethoxylates and nonylphenol polyethoxylates recommended in the 39th 
Report (62 FR 8578, February 25, 1997) (FRL-5580-9) and for 
alkylphenols, polyalkylphenols, and alkylphenol polyethoxylates 
recommended in the 41st Report (63 FR 17658, April 9, 1998) (FRL-5773-
5). In addition, the ITC considered use and health and safety data 
voluntarily submitted to the ITC by the Chemical Manufacturers 
Association (CMA) Alkylphenols and Ethoxylates (AP&E) Panel before 
VISION was developed, health and safety data voluntarily submitted 
through VISION as well as TSCA section 8(d) health and safety data 
submitted for structurally related chemicals in the 37th Report (61 FR 
4188, February 2, 1996) (FRL-4991-6). After considering this 
information, and determining that it was not adequate to meet the data 
needs for these chemicals, the ITC decided to ask EPA to promulgate a 
TSCA section 8(d) HaSD rule for the nonylphenol ethoxylates recommended 
in the 39th Report and the alkylphenols recommended in the 41st Report. 
These chemicals are listed in Table 2.
    2. 42nd Report chemicals. The ITC sent its 42nd Report (63 FR 
42554, August 7, 1998) (FRL-5797-8) to manufacturers of 3-amino-5-
mercapto-1,2,4-triazole, glycoluril, and methylal and requested that 
they use VISION to provide data to meet the U.S. Government data needs 
described in the 42nd Report. Since no information to meet these data 
needs was received, the ITC is asking EPA to promulgate a TSCA section 
8(d) HaSD rule for these chemicals to determine if there are 
unpublished data to meet those needs. The ITC also contacted the 
Silicones Environmental Health and Safety Council (SEHSC) about 
providing data for ethyl silicate. The SEHSC agreed to meet with the 
ITC to discuss data needs. If needed data are not provided, the ITC 
will consider asking EPA to promulgate a TSCA section 8(d) HaSD rule 
for ethyl silicate.

 Table 2.--Chemicals for Which the ITC is Requesting That EPA Promulgate
                      a TSCA Section 8(d) HaSD Rule
------------------------------------------------------------------------
                                                           ITC Report
                                                         describing U.S.
            CAS No.                  Chemical name       Government data
                                                              needs
------------------------------------------------------------------------
 
                              Pe  ....................
136-81-2......................  Phenol, 2-pentyl-.....  41
3279-27-4.....................  Phenol, 2-(1,1-         41
                                 dimethylpropyl)-.
25735-67-5....................  Phenol, 4-sec-pentyl-.  41
26401-74-1....................  Phenol, 2-sec-pentyl-.  41
 
                              He  ....................
2446-69-7.....................  Phenol, 4-hexyl-......  41
 
                              He  ....................
1987-50-4.....................  Phenol, 4-heptyl-.....  41
72624-02-3....................  Phenol, heptyl derivs.  41
84605-25-4....................  Phenol, 1-methylhexyl   41
                                 derivs..
 
                              Oc  ....................
140-66-9......................  Phenol, 4(1,1,3,3-      41
                                 tetramethylbutyl).
71902-25-5....................  Phenol, octenylated...  41
 
                              No  ....................
68081-86-7....................  Phenol, nonyl derivs..  41
91672-41-2....................  Phenol, 2-nonyl-,       41
                                 branched.
 
                              De  ....................
27157-66-0....................  Phenol, tetradecyl-...  41
 

[[Page 65238]]

 
                             Dod  ....................
74499-35-7....................  Phenol,                 41
                                 (tetrapropenyl)
                                 derivs..
 
                            Tetr  ....................
70682-80-3....................  Phenol, tetradecyl-...  41
 
                            Hexa  ....................
2589-78-8.....................  Phenol, hexadecyl.....  41
25401-86-9....................  Phenol, 2-hexadecyl-..  41
 
                           Other  ....................
68784-24-7....................  Phenol, C18-30-alkyl    41
                                 derivs..
 
                         Nonylph  ....................
7311-27-5.....................  Ethanol, 2-[2-[2-[2-(4- 39
                                 nonylphenoxy)ethoxy]e
                                 thoxy]ethoxy]-.
20427-84-3....................  Ethanol, 2-[2-(4-       39
                                 nonylphenoxy)ethoxy].
20636-48-0....................  3,6,9,12-               39
                                 Tetraoxatetradecan-1-
                                 ol, 14-(4-
                                 nonylphenoxy).
26264-02-8....................  3,6,9,12-               39
                                 Tetraoxatetradecan-1-
                                 ol, 14-(nonylphenoxy)-
                                 .
26571-11-9....................  3,6,9,12,15,18,21,24-   39
                                 Octaoxahexacosan-1-
                                 ol, 26-(nonylphenoxy)-
                                 .
27176-93-8....................  Ethanol, 2-[2-          39
                                 (nonylphenoxy)ethoxy]-
                                 .
27177-01-1....................  3,6,9,12,15-            39
                                 Pentaoxaheptadecan-1-
                                 ol, 17-(nonylphenoxy)-
                                 .
27177-05-5....................  3,6,9,12,15,18,21-      39
                                 Heptaoxatricosan-1-
                                 ol, 23-(nonylphenoxy).
27177-08-8....................  3,6,9,12,15,18,21,24,2  39
                                 7-Nonaoxanonacosan-1-
                                 ol, 29-(nonylphenoxy)-
                                 .
27986-36-3....................  Ethanol, 2-             39
                                 (nonylphenoxy)-.
65455-72-3....................  3,6,9,12,15,18,21,24,2  39
                                 7-Nonaoxanonacosan-1-
                                 ol, 29-
                                 (isononylphenoxy)-.
98113-10-1....................  Nonoxynol-9...........  39
NA\1\.........................  Nonoxynol-2...........  39
NA\1\.........................  Nonoxynol-3...........  39
NA\1\.........................  Nonoxynol-7...........  39
 
                             Oth  ....................
109-87-5......................  Methylal..............  42
496-46-8......................  Glycoluril............  42
16691-43-3....................  3-Amino-5-mercapto-     42
                                 1,2,4-triazole.
------------------------------------------------------------------------
\1\Not available

III. ITC's Dialogue Group Activities During This Reporting Period 
(May to November 1998)

    The CMA-ITC AP&E Dialogue Group was formed by the CMA's AP&E Panel 
and the ITC's AP&E Subcommittee in March 1996 following the submission 
of the ITC's 37th Report to the EPA Administrator in November 1995. The 
Group was created to facilitate the ITC's retrieval of information on 
uses, exposures, and health and ecological effects of alkylphenols and 
alkylphenol ethoxylates, and the Panel's understanding of data needed 
by the U.S. Government organizations represented on the Subcommittee. 
Since the creation of this Dialogue Group, numerous activities have 
occurred: See the ITC's 38th Report (61 FR 39832, July 30, 1996) (FRL-
5379-2); 39th Report; 40th Report (62 FR 30580, June 4, 1997) (FRL-
5718-3); 41st Report, and 42nd Report.
    After the 42nd Report was delivered to the EPA Administrator, some 
members of the CMA's AP&E Panel formed the APE Research Council 
(APERC). The APERC-ITC AP&E Dialogue Group met twice during this 
reporting period. On August 12 and October 15, 1998, the Dialogue Group 
met to discuss:
    1. Status of TSCA section 8(a) PAIR and TSCA section 8(d) rules for 
the 39th and 41st ITC Reports.
    2. Number and type of studies on alkylphenols and alkylphenol 
ethoxylates sent to VISION.
    3. Status of research related to U.S. Government data needs for 
alkylphenols and alkylphenol ethoxylates (e.g., multigeneration fish 
studies to determine offspring reproductive capabilities).
    4. Progress and results of ongoing environmental and toxicological 
studies being conducted or sponsored by chemical manufacturers on the 
Council, (e.g., mammalian in vitro and in vivo toxicology, mammalian 
pharmacokinetic, biodegradation, aquatic toxicity, and avian acute 
toxicity studies).
    5. Organization for Economic Cooperation and Development (OECD) 
Screening Information Data Set (SIDS) dossiers on nonylphenol and 
nonylphenol ethoxylates.
    6. Alkylphenols that may be removed from the Priority Testing List.
    7. Alkylphenols and nonylphenol ethoxylates being considered for 
Quantitative Structure Activity Relationship (QSAR) studies.

IV. Revisions to the TSCA Section 4(e) Priority Testing List

A. Summary Table of Changes

    Revisions to the TSCA section 4(e) Priority Testing List are 
summarized in Table 3.

[[Page 65239]]



                       Table 3.--Revisions to the TSCA section 4(e) Priority Testing List
----------------------------------------------------------------------------------------------------------------
               CAS No.                      Chemical name                Action                    Date
----------------------------------------------------------------------------------------------------------------
                                                                Remove                   November 1998
  ...................................           HPVCs             .....................
80-51-3..............................  p,p'-                              do.                      do.
                                        Oxybis(benzenesulfonyl
                                        hydrazide).
81-84-5..............................  Naphthalenedicarboxylic            do.                      do.
                                        anhydride.
99-54-7..............................  3,4-                               do.                      do.
                                        Dichloronitrobenzene.
100-29-8.............................  4-Ethoxynitrobenzene...            do.                      do.
119-33-5.............................  4-Methyl-2-nitrophenol.            do.                      do.
121-60-8.............................  4-(Acetylamino)                    do.                      do.
                                        benzenesulfonyl
                                        chloride.
626-17-5.............................  1,3-Dicyanobenzene.....            do.                      do.
929-06-6.............................  2-(2-Aminoethoxy)                  do.                      do.
                                        ethanol.
3089-11-0............................  Hexa(methoxymethyl)                do.                      do.
                                        melamine.
                                             Butylphenols
3180-09-4............................  2-Butylphenol..........            do.                      do.
27178-34-3...........................  tert-Butylphenol mixed             do.                      do.
                                        isomers.
  ...................................       Pentylphenols
94-06-4..............................  4-(1-Methylbutyl)phenol            do.                      do.
                                             Octylphenols
949-13-3.............................  2-Octylphenol..........            do.                      do.
27985-70-2...........................  (1-Methylheptyl)phenol.            do.                      do.
  ...................................        Nonylphenols
11066-49-2...........................  Isononylphenol (mixed              do.                      do.
                                        isomers).
17404-66-9...........................  4-(1-Methyloctyl)phenol            do.                      do.
  ...................................  Octylphenol Ethoxylates
2315-66-4............................  Decaethylene glycol 4-             do.                      do.
                                        isooctylphenyl ether.
2497-58-7............................  Hexaethylene glycol 4-             do.                      do.
                                        isooctylphenyl ether.
----------------------------------------------------------------------------------------------------------------

B. Chemicals Removed From the Priority Testing List

    1. HPVCs--a. Rationale. The ITC is removing 9 HPVCs (Table 3) from 
the Priority Testing List because:
    i. EPA, CMA, and the Environmental Defense Fund have agreed, that 
by the year 2003, data will be provided or developed for about 3,000 
HPVCs produced or imported into the United States.
    ii. The 3,000 HPVCs includes the 9 HPVCs on the Priority Testing 
List.
    iii. At this time, there are no specific U.S. Government data needs 
for these chemicals that would not be met by the HPV Chemical Challenge 
Program.
    b. Supporting information. HPVCs are chemicals with annual domestic 
production or importation volumes greater than 1 million pounds. 
Information on ITC's review of HPVCs is contained in Reports 27th (56 
FR 9534, March 6, 1991) (FRL-3845-3), 35th (59 FR 67596, December 29, 
1994) (FRL-4923-2), 36th (60 FR 42982, August 17, 1995) (FRL-4965-6), 
37th, 38th, and 40th.
    The ``Screening Information Data Set (SIDS) Manual of the OECD 
Programme on the Co-operative Investigation of High Production Volume 
Chemicals,'' provides test guidance for developing data for HPVCs. The 
basic screening endpoints are listed in section 2.2 (page 2) of this 
Manual (the ``SIDS Manual;'' available at http://www.epa.gov/opptintr/sids/sidsman.htm).
    2. Alkylphenols and alkylphenol ethoxylates--a. Rationale. The ITC 
is removing 2 butylphenols, 1 pentylphenol, 2 octylphenols, 2 
nonylphenols, and 2 octylphenol ethoxylates (Table 3) from the Priority 
Testing List because no domestic production or importation volumes were 
reported to the EPA in response to 1986, 1990, and 1994 Information 
Update Rules (indicating that volumes were less than 10,000 pounds per 
site in 1985, 1989, and 1993), no domestic production or importation 
volumes were reported to the EPA in response to the February 28, 1996, 
PAIR rule (indicating that volumes were less than 1,000 pounds per site 
in 1995), no TSCA section 8(d) studies were submitted to the EPA in 
response to the February 28, 1996, HaSD rule and because no TSCA 
section 8(e), FYI, or ITC studies were available for these chemicals as 
of September 1998.
    b. Supporting information. Information on the ITC's review of 
alkylphenols and alkylphenol ethoxylates is contained in Reports 37, 
38, 39, 40, and 41. The ITC reviewed use and health and safety data 
voluntarily submitted to the ITC by the CMA-ITC AP&E Dialogue Group 
before VISION was developed and health and safety data voluntarily 
submitted through VISION.

V. TSCA Interagency Testing Committee

Statutory Organizations and Their Representatives

Council on Environmental Quality
    Brad Campbell, Member
Department of Commerce
National Institute of Standards and Technology
    Malcolm W. Chase, Member
    Barbara C. Levin, Alternate
National Oceanographic and Atmospheric Administration
    Nancy Foster, Member
    Teri Rowles, Alternate
    Richard S. Artz, Alternate
Environmental Protection Agency
    Paul Campanella, Member
    David R. Williams, Alternate
National Cancer Institute
    Victor Fung, Member, Chair
    Harry Seifried, Alternate
National Institute of Environmental Health Sciences
    William Eastin, Member, Vice Chair
    H.B. Matthews, Alternate
National Institute for Occupational Safety and Health
    Albert E. Munson, Member
    Christine Sofge, Alternate
National Science Foundation
    A. Frederick Thompson, Member
    Joseph Reed, Alternate
Occupational Safety and Health Administration
    Lyn Penniman, Member
    Val H. Schaeffer, Alternate

Liaison Organizations and Their Representatives

Agency for Toxic Substances and Disease Registry
    William Cibulas, Member
Consumer Product Safety Commission
    Jacqueline Ferrante, Member
Department of Agriculture

[[Page 65240]]

    ;Clifford P. Rice, Member
Department of the Interior
    Barnett A. Rattner, Member
Food and Drug Administration
    Edwin J. Matthews, Member
    Raju Kammula, Alternate
National Library of Medicine
    Vera W. Hudson, Member
National Toxicology Program
    NIEHS, FDA, and NIOSH Members
Counsel
    Scott Sherlock, OPPT, EPA
Technical Support Contractor 
    Syracuse Research Corporation
ITC Staff
    John D. Walker, Executive Director
    Norma S. L. Williams, Executive Assistant

    TSCA Interagency Testing Committee, Office of Pollution Prevention 
and Toxics (7401), Environmental Protection Agency, Ariel Rios Bldg., 
1200 Pennsylvania Ave., NW., Washington, DC 20460; telephone: (202) 
260-1825; fax: (202) 260-7895; e-mail address: <a href="/cdn-cgi/l/email-protection#cdbaa4a1a1a4aca0bee3a3a2bfa0ac8da8bdace3aaa2bb"><span class="__cf_email__" data-cfemail="e097898c8c89818d93ce8e8f928d81a0859081ce878f96">[email protected]</span></a>; 
url: http://www.epa.gov/opptintr/itc.

[FR Doc. 00-27926 Filed 10-30-00; 8:45 am]
BILLING CODE 6560-50-F


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