1 United States Chemical Safety September 2012 Environmental Protection and Pollution Prevention Agency (7510P)



# Ammonium Bromide Summary Document: Registration Review : Initial Docket September 2012Docket Number: EPA-HQ-OPP-2012-0683 www.regulations.gov



## Ammonium Bromide Summary Document Registration Review: Initial Docket September 2012

Case# 5002

Approved By: 

# £r " •

# ~Harri**:Z: ~**  Duector, Antimicrobials DIVISion

Date:

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### TABLE OF CONTENTS

Ammonium Bromide Registration Review Team

................................ ................................ .......... 4 I. Pre liminary Work Plan

-- Ammonium Bromide

................................ ................................ ......... 5 II. Fact Sheet

................................ ................................ ................................ ................................ . 12 III. Summary of An ticipated Data Requirements

– Ammonium Bromide

................................ ... 16 IV. Appendix A: Use Patterns

– Ammonium bromide

................................ ................................ 17

________________________________________
Please Note

This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's current position based on the following documents:

1. Product Chemistry, Environmental Fate, and Ecological Effects Scoping Document in Support of Registration Review of Ammonium Bromide

. September 2 4 , 2012

2. Ammonium Bromide: Human Health Registration Review Scoping Document

. September 1 9 , 2012

Addi tional supporting documents for the Ammonium Bromide Case may be found in the registration review docket EPA

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.Docket Number: EPA

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4 Ammonium Bromide Registration Review Team

Human Health & Environmental Effects Timothy Dole Jenny Tao William Hazel Srinivas Gowda Najm Shamim William Erickson

Risk Management Rebecca von dem Hagen Lance Wormell

Office of General Counsel Philip RossDocket Number: EPA

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5 I. Preliminary W ork Plan

-- Ammonium Bromide

Introduction:

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review program

. All pesticides distributed or sold in the United States generally must be registered by the U.S. Environmental Protection Agency (USEPA, EPA, or the Agency) based on scientific data showing that they will not cause unreasonable risks to human health or the environment when used as directed on product labeling

. The registration review program is intended to make sure that, as the ability to assess risk evolves and as policies and practices change, all registered pesticides continue to meet the statutory stan dard of no unreasonable adverse effects to human health or the environment

. Changes in science, public policy, and pesticide use practices will occur over time

. Through the registration review program, the Agency periodically reevaluates pesticides to make sure that as change occurs, products in the marketplace can be used safely

. Information on this program is provided at http://www.epa.gov/oppsrrd1/registration_review/

. The Agency is implement ing the registration review program pursuant to Section 3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered pesticide every 15 years to determine whether it continues to meet the FIFRA standard for regist ration

. The Agency will consider benefits information and data as required by FIFRA

. The public phase of registration review begins when the initial docket is opened for each case

. The docket is the Agency’s opportunity to state what it knows about the pes ticide and what additional risk analyses and data or information it believes are needed to make a registration review decision

. After reviewing and responding to comments and data received in the docket during this initial comment period, the Agency will d evelop and commit to a final work plan and schedule for the Ammonium Bromide C ase.
The first product containing ammonium bromide (PC Code 000352, Case #5002) as an active ingredient was registered in the United States in 1999 for use in recirculating cooli ng water systems and pulp and papermills. Currently, there are five products containing ammonium bromide as the active ingredient registered with the EPA. Ammonium bromide is an algicide, bactericide, microbicide and slimicide registered for use in indus trial process and water systems such as recirculating cooling towers, pulp and papermills and wastewater treatment systems. Paper and paperboard treated with ammonium bromide are approved for food contact use. The registered ammonium bromide product s may be mixed on

- site with a substance such as sodium hypochlorite or chlorine gas to form a monochloramine solution. The monochloramine solution is the active biocide in the pulp, papermill and other industrial water systems. Ammonium bromide is not registere d for use in drinking water systems. Products registered as ammonia (PC Code 005302, Case #7440 ) and ammonium sulfate (PC Code 005601, Case # 5073) are also used in conjuction with an oxidizing agent to form a monochloromine solution; however, the Agency is evaluating ammonia and ammonium sulfate under separate registration review case s because the chemical reaction of ammonium bromide when mixed on

- site as n oted above results in the formation of hypobromous acid in addition to monochloramine.

EPA did not complete a reregistration eligibility decision (RED) for ammonium bromide because the first pesticide product containing ammonium bromide was registered afte r November 1, 1984.Docket Number: EPA

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6 Documents associated with the registration review of a mmonium bromide can be viewed at www.regulations.gov in docket EPA

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. Documents associated with the registration review of the Ammonia and Ammonium Sulfate Cases can be viewed at www.regulations.gov in docket EPA

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. Below is a summary of the issues relevant to th is registration review case.

Anticipated Risk Assessment and Data Needs:

The Agency does not anticipate the need to conduct an ecological risk assessment. The Agency anticipates the need to conduct a human health risk assessment. The Agency anticipates needing additional data for use in conducting the registration review for a mmonium bromide.

Ecological Risk:

• A quantiative ecological risk assessment has not been performed for a mmonium bromide due to the low likelihood of exposure

.

• Based on the low likelihood of exposure, the Agency intends to con clude that the registered uses of a mmonium bromide will have 'no effect' (NE) on endangered or threatened terrestrial or aquatic species, or their designated critical habitats, as listed by the U.S. Fish and Wildlife Service (USFWS) and the National Oceani c and Atmospheric Administration's (NOAA) National Marine Fisheries Service (NMFS). EPA anticipates conducting no further analysis of potential risks to endangered or threatened species unless public comment provides data or information that would otherwi se inform the Agency's determination.

• The Agency does not anticipate the need to require additional ecological or environmental fate data for th is registration review case at this time.

• F or more information

, please refer to Product Chemistry, Environmental Fate, and Ecological Effects Scoping Document in Support of Registration Review of Ammonium Bromide , located in the docket

.
Human Health Risk:

• A human health risk assessment has not been performed for a mmonium bromide

.

• The Agency anticipates the need to conduct an occupational exposure risk assessment for the registration review of ammonium bromide. If labels were amended to require that a closed system be used for the mixing of ammonium bromide and sodium hypochlorite or another chlorine source , then the Agency anticipates that a risk assessment will no longer be needed because human exposure will not occur.

• The Agency anticipates the need to require the following additional human health data for use in the registration review of a mmonium bromide.

875.3465

– 28

- day inhalation toxicity 875.1400

-- Inhalation indoor exposureDocket Number: EPA

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7 875.1600

-- Application exposure data reporting and calculations

• F or more information

, please refer to Ammonium Bromide: Human Health Registration Review Scoping Document
, located in the docket

. Product Chemistry:

• The Agency anticipate s the need to require the following additional product chemistry data for use in the registration review of ammonium bromide.

830.7520

– Particle size

• F or more information

, please refer to Product Chemistry, Environmental Fate, and Ecological Effects Scoping Document in Support of Registration Review of Ammonium Bromide and Ammonium Bromide: Human Health Registration Review Scoping Document
, located in the docke t

. Endocrine Disruptor Screening Program

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse outcomes from exposure to chemicals

. Collectively, these studies include acute, subchronic and chronic toxicity, including ass essments of carcinogenicity, neurotoxicity, developmental, reproductive, and general or systemic toxicity. These studies include endpoints which may be susceptible to endocrine influence, including effects on endocrine target organ histopathology,
organ we ights, estrus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, and sex ratios in offspring

. For ecological hazard assessments, EPA evaluates acute tests and chronic studies that assess growth, developmental and reproductive effe cts in different taxonomic groups

. A human health risk assessment identifying the most sensitive endpoints has not been conducted for ammonium bromide

. However, as required by FFDCA section 408(p),

a mmonium bromide is subject to the endocrine screening par t of the Endocrine Disruptor Screening Program (EDSP).

EPA has developed the EDSP to determine whether certain substances (including pesticide active and other ingredients) may have an effect in humans or wildlife similar to an effect produced by a “natur ally occurring estrogen, or other such endocrine effects as the Administrator may designate.” The EDSP employs a two

- tiered approach to making the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays to identify the pote ntial of a chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal systems

. Chemicals that go through Tier 1 screening and are found to have the potential to interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 testing is designed to identify any adverse endocrine

- related effects caused by the substance, and establish a dose

- respon se relationship between the dose and the E, A, or T effect.

Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between October 2009 and February 2010, EPA issued test orders/data call

- ins for the first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 inert ingredients. Ammonium bromide is notDocket Number: EPA

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8 among the group of 58 pesticide active ingredients on the initial list to be screened under the EDSP. Accordingly, as part of registration review, EPA will issue futu re EDSP orders/data call

ins, requiring the submission of EDSP screening assays for a mmonium bromide

. For further information on the status of the EDSP, the policies and procedures, the list of 67 chemicals, future lists, the test guidelines and the Tier 1 screening battery, please visit our website: http://www.epa.gov/endo/

.
Timeline

EPA has created the following estimated timeline for the completion of the a mmonium bromide registration review:

Anticipated Schedule Activities Estimated Month/Year
Phase 1: Opening the docket Open Docket and 60

- Day Public Comment Period for PWP September 2012 Close Public Comment Period for Docket November 2012 Phase 2: Case Development Develop Final Work Plan (FWP) March 2013 Issue DCI March 2014 Data Submission March 2015 Open 30

- Day Public Comment Period for Preliminary Risk Assessments September 201 6

Close Public Comment Period for Preliminary Risk Assessments October 201 6 Phase 3: Registration Review Decision Open 60

- Day Public Comment Period for Proposed Reg. Review Decision March 201 7

Close Public Comment Period for Proposed Reg. Review Decision May 201 7 Final Decision and Begin Post

- Decision Follow

- up 201 7 Total (years) 5

Guidance for Commenters:

The public is invited to comment on EPA’s P reliminary W ork P lan and rationale

. The Agency will carefully consider all comments as well as any additional information or data provided in a timely manner prior to issuing a final work plan for the a mmonium bro mide registration review

case.

Trade Irritants:

Through the registration review process, the Agency intends to solicit information on trade irritants and, to the extent feasible, take steps toward facilitating irritant resolution

. Growers and other stakeholders are asked to comment on any trade irritant issues resulting from lack ofDocket Number: EPA

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9 Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key export markets, providing as much specificity as possible regarding the nature of the concern.

Water Quality:

Ammonium bromide is not identified as a cause of impairment for any water bodies listed as impaired under section 303(d) of the Clean Water Act, based on information provided at http://iaspub.epa.gov/tmdl_waters 10/attains_nation_cy.cause_detail_303d?p_cause_group_id=88 5. In addition, no Total Maximum Daily Loads (TMDL) have been developed for a mmonium bromide , based on information provided at http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detai l?p_pollutant_group_id =885&p_pollutant_group_name=PESTICIDES.

More information on impaired water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/

. The Agency invites submission of water quality data for this pesticide

. To the extent possible, data should conform to the quality standards in Appendix A of the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water Quality Data in OPP’s Registration Review Risk Assessment and Management Process (see: http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm ), in order to ensure the data can be used quantitatively or qualitatively in pesticide risk assessments.

Environmental Justice:

EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all people, regardless of race, color, national origin, or income, in the development, implementation, and enfor cement of environmental laws, regulations, and policies. To help address potential environmental justice issues, the Agency seeks information on any groups or segments of the population who, as a result of their location, cultural practices, or other facto rs, may have atypical, unusually high exposure to a mmonium bromide compare d to the general population. Please comment if you are aware of any sub

- populations that may have atypical, unusually high exposure compared to the general population.

Structure Activity Relationships:

EPA must rely upon information of appropriate quality and reliability for each decision made by the Agency

. In the Office of Pesticide Programs (OPP), the evaluation process for a pesticide chemical traditionally begins w ith the applicant’s submission of a set of studies conducted with the specific pesticide chemical of interest

. The use of the results of such testing (measured data) is a logical, scientifically rigorous process that identifies the physical, chemical, and environmental fate properties of the pesticide, as well as the dose and endpoints at which an adverse effect can occur in various animal species.

Today, there is significant interest in alternative techniques, i.e., techniques other than data generation t hat could significantly inform the Agency’s decision

- making process

. Recently, OPP has made increasing use of structure activity relationship (SAR) as part of its regulatory decision

- making process

. In the SAR process, a chemical's molecular structure is compared toDocket Number: EPA

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10 that of other chemicals for which data are available

. These structural similarities are then used to make predictive judgments about a chemical’s physical, chemical, and biological propert ies

. Thus, the chemical’s physical, chemical, and biological properties are a function of (or directly related to) the chemical’s molecular structure

. Quantitative SAR is referred to as QSAR

. To develop a QSAR, a selected set of measured data on a single p hysical, chemical, or biological property is used to derive a model (an equation) to predict the value of that property

. Since SAR assessments and QSAR modeling are another set of tools that are available to Agency scientists, OPP has begun a process shif t that envisions shifting from the current study

- by

- study approach to an approach in which the use of predicted data, generated using validated models, is considered along with information from open literature and studies specifically generated under Part 161 requirements

. All relevant information would be considered as part of a weight

- of

- the

evidence evaluation

. At this time, EPA believes that for certain endpoints, especially physical/chemical and fate properties, that SAR and QSAR might be effectively utilized to fulfill these data requirements for many antimicrobial pesticide chemicals

. When considering biological properties, at this time, EPA believes that SAR and QSAR can be most effectively utilized in the evaluation of chemicals that exhibit lower toxicity for human health and/or ecotoxicity parameters

. This is appropriate because the risk assessment for lower toxicity chemicals can be stream

- lined, i.e., a screening

- level assessment procedure rather than multiple tiers of assessments with progressi vely more data requirements.

If stakeholders believe that submission of predicted data can fulfill one of the data needs for the

a mmonium b romide c ase, then the Agency invites submission of this information

. The submitter would be expected to supply a rati onale describing the utility of the information and provide documentation on the scientific validity of the information

. The determination that the predicted data fulfills the data requirement would be at the sole discretion of the Agency

. Pre

- submission

c onsultation with the Agency is encouraged.

Additional Information:

Stakeholders are also specifically asked to provide available information and data that will assist the Agency in refining its risk assessments , including any species

- specific ecological ef fects determinations. The Agency is interested in receiving the following information:

1. Confirmation on the following label information:

a. Sites of application b. Formulations

c. Application methods and equipment d. Maximum application rates

e. Frequency of application, application intervals and maximum number of applications f. Geographic limitations on use 2. Use or potential use distribution 3. Use history 4. Usage/use information for non

- agricultural uses (e.g., materials preservation)Docket Number: EPA

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11 5. Typical application interval 6. State or local use restrictions 7. Ecological incidents (non

- target plant damage and avian, fish, reptilian, amphibian and mammalian mortalities) not already reported to the Agency 8. Monitoring data

Next Steps:

After the 60

- day comment period closes in November 2012 , the Agency will review and respond to any comments received in a timely manner, and then issue a Final Work Plan for the

a mmonium b romide C ase

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12 II. Fact Sheet

Background Information:

• Active Ingredient: a mmonium bromide

• C ase number: 5002

• PC Code: 00035 2

• CAS number : 12124

- 97

- 9

• Technical registrants: ICL

- IP America, Inc.

• First approved for use in a registered product: 1999

• There are no tolerances or exemptions from a tolerance for ammonium bromide.

• Antimicrobials Division Chemical Review Manager (CRM): Rebecca von dem Hagen

, vondem

- hagen.rebecca@epa.gov

• Antimicrobials Division Product Manager (PM): Monisha Harris

, harris.monisha@epa.gov

• Chemical Structure:

Use & Usage Information:

• Ammonium bromide is an algicide, bactericide, microbicide and slimicide registered for use in industrial process and water systems such as recirculating cooling towers, pulp and papermills and wastewater treatment systems. Paper and paperboard are approved for food contact use.

• The registered ammonium bromide product s may be mixed on

- site by authorized personnel with a substance such as sodium hypochlorite or chlorine gas to form a monochloramine solution. The monochloramine solution is the active biocide in the pulp, papermill and other industrial water systems.

Re cent/Pending Regulatory Actions :

• There are no recent or pending regulatory actions for ammonium bromide.

Ecological Risk Assessment Status:

Please refer to Product Chemistry, Environmental Fate, and Ecological Effects Scoping Document in Support of Registration Review of Ammonium Bromide , located in the docket, for a detailed discussion of the ecological risk assessments.

• A quantitative ecological risk assessment has not been conducted on ammonium bromide due to the low likelihood of exposure.Docket Number: EPA

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13 Human Health Risk Assessment Status:

The following are key findings of the recent human health risk assessments for Ammonium bromide . Please refer to Ammonium Bromide: Human Health Registration Review Scoping Document
, located in the docket, for a detailed disc ussion of the human health risk assessment.

Hazard Characterization:

• Ammonium bromide is of low acute oral, dermal, and inhalation toxicity (Toxicity Category III). Ammonium bromide is irritating to the eyes (Toxicity Category II) but not to the skin (Tox icity Category IV). Ammonium bromide is not a dermal sensitizer.

Dietary (Food and Water):

• The Agency believe s that the only potentially toxic compound resulting from ammonium bromide use in the water system is mono chloramine . N o residues of potential
tox icological concern are expected to survive the paper or paperboard manufacturing processes. Any monochloramine not consumed in the water system is expected to degrade under the high temperature conditions of the paper drying process (110 °C); therefore, di etary (food) exposure is not expected.

• A drinking water assessment has not been conducted due to the low likelihood of exposure. EPA’s Office of Water has established a maximum residual disinfectant level (MRDL) of 4.0 ppm and water utilities are required to maintain total chloramines at or below this MRDL. Given this limit, the fact that the maximum application rate is 10 ppm (for paper mills), and the fact that most of the monochloramine will be consumed during the treatment process, the Agency does not anticipate drinking water exposures to monochloramine. Ammonium bromide is not registered for use in drinking water systems.

Residential:

• A residential assessment has not been conducted for the ammonium bromide products because residential exposure is not expected from the registered use patterns.

Aggregate:

• In examining aggregate exposure, EPA takes into account the available and reliable information concerning exposures to pesticide residues in food and drinking water, as well as non

- occupational pest icide exposures. An aggregate risk assessment ha s not been deemed necessary for a mmonium bromide due to the lack of residential and dietary
exposure.
Occupational:

• The most recent occupational exposure assessment on ammonium bromide was conducted in 2002 i n support of the registration of ammonium bromide as a liquid applied in a closed system. No risks of concern were identified.Docket Number: EPA

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14 • An occupational risk assessment has not been conducted for the solid ammonium bromide products

.
Cumulative:

• EPA does not have, at this time, available data to determine whether a mmonium bromide has a common mechanism of toxicity with other substances or how to include this pesticide in a cumulative risk assessment. For the purposes of this Registration Review, EPA has assumed tha t a mmonium bromide does not have a common mechanism of toxicity with other substances when used as an antimicrobial as registered.

Incidents:

Ecological:

• No a mmonium bromide ecological incidents have been reported in the OPP incident database.

Human Health:

• No a mmonium bromide human poisoning incidents have been reported in the OPP incident database.

Tolerances and International Harmonization:

• There are no tolerances or exemptions from a tolerance established for ammonium bromide.

Data Call

- In Status :

• No data call

- ins have been issued for the registered ammonium bromide products.

Labels:

Registered products, including EPA registration numbers are provided in Table 1 below

. For future reference, during registration review a list of product registration numbers will be included in the docket. Product registration labels may be obtained from the Pesticide Product Label System (PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home

.
Table 1

. Registered Products

– Ammonium Bromide

Registration # Registration Name Company Name Formulation Type % of Active Ingredient

8622

- 58 Fuzzicide

- Comp ICL

- IP America, Inc. Soluble Concentrate 99

8622

- 59 Ammonium Bromide

- Comp ICL

- IP America, Inc. Technical Chemical 99

8622

- 64 Fuzzicide Solution ICL

- IP America, Inc. Ready

- to

- Use 35Docket Number: EPA

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Registration # Registration Name Company Name Formulation Type % of Active Ingredient

Solution

8622

- 75 Ammonium Bromide

- SP ICL

- IP America, Inc. Technical Chemical 99

8622

- 76 Fuzzicide

- SP (Ammonium Bromide) ICL

- IP America, Inc. Soluble Concentrate/Solid 99Docket Number: EPA

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16 III. Summary of Anticipated Data Requirements

– Ammonium Bromide

The table below summarizes anticipated data needs for the Ammonium Bromide Case in Section I of this document (Preliminary Work Plan), Product Chemistry, Environmental Fate, and Ecological Effects Scoping Document in Support of Registration Review of Ammonium Bromide

, and Ammonium Bromide: Human Health Registration Review Scoping Doc ument

. Table 2. Summary of Anticipated Data Requirements

– Ammonium Bromide

Guideline Number Anticipated Data Requirement Test Material Estimated Timeframe (Measured in months

from DCI Receipt)

870.3465 28

- day inhalation toxicity 1

, 2 TGAI 12

875.1400 Inhalation indoor exposure 2 TGAI/MUP 12

875.1600 Application exposure data reporting and calculations 2 TGAI/MUP 12

830.7520 Particle size 2 EUP 12

1 Although Guideline 870.3465 is for a 90

- day inhalation toxicity test, the Agency would consider accepting a 28

- day inhalation toxicity study.
2 If labels are amended to require mixing of ammonium bromide and sodium hypochlorite or another chlorine source in a closed system, registrants ma y request that EPA waive the requirement for Guidelines 870.3465, 875.1400, 875.1600 and 830.7520.17 IV. Appendix A : Use Patterns

– Ammonium bromide

EPA Reg Number used for Max. Appl. Rate Formulation % Active Ingredient in End Use Formulation Use Category Use Site Treatment Site/surfaces Method of Application Max Application/Use Rate Use Limitations

8622

- 58 Soluble Concentrate 99 Industrial
processes and water systems Recirculating cooling systems Industrial cooling towers, evaporative condensers, heat exchange water towers, influent systems such as flow through filters, industrial water scrubbing systems, brewery pasteurizers, sewage systems (septic tanks, leach fields, tank lines, sewers, lagoons, and sewage effluent water), industrial air

washing systems equipped with a mist eliminator. Metered 0.3

- 5.0 ppm of residual biocide expressed as total chlorine. Recommended dosage may be achieved by mixing 1.5 pounds of chlorine gas (99.9%) or 1.3 gallons NaOCI (12.5%) with each aqueous solution containing 2.2 pounds of end use product. End use product i s to be used only in conjunction with: 1) an oxidant such as sodium hypochlorite (12.5%) or chlorine gas (99.9%) to and 2) the approved feeder/delivery system.Docket Number: EPA

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18

8622

- 58 Soluble Concentrate 99 Industrial
processes and water systems Pulp and paper mills Pulp and paper mill fresh and
sea water influent systems, and associated cooling water systems and
wastewater treatment systems, pulp, paper and paper board mills systems, nonpotable water systems, starch slurries, and other process water that may
contact food. Metered 0.3

- 10.0 ppm of residual biocide expressed as total chlorine. Recommended dosage may be achieved by mixing 1.5 pounds of chlorine gas (99.9%) or 1.3 gallons NaOCI (12.5%) with each aqueous solution containing 2.2 pounds of end use product. En d use product is to be used only in conjunction with: 1) an oxidant such as sodium hypochlorite (12.5%) or chlorine gas (99.9%) to and 2) the approved feeder/delivery system. Do not exceed 0.5 pounds per 2205 pounds of dry weight fiber in paper and paperb oard components that contact food.

8622

- 59 Technical Chemical 99 This product is for FORMULATING USE ONLY into EPA registered antimicrobials for the following use: recirculating cool water systems, pulp and papermills.Docket Number: EPA

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19

8622

- 64 Ready

- to

- Use Solution 35 Industrial
processes and water systems Recirculating cooling systems Industrial cooling towers, evaporative condensers, heat exchange water towers, influent systems such as flow through filters, industrial water scrubbing systems, brewery pasteurizers, sewage systems (septic tanks, leach fields, tank lines, sewers, lagoons, and sewage effluent water), industrial air

washing systems equipped with a mist eliminator. Metered 0.3

- 5.0 ppm of residual biocide expressed as total chlorine. 0.54 gallons of Sodium Hypochlorite (12.5%) with 0.22 gallons of end use product End use produ ct is to be used only in conjunction with: 1) an oxidant such as sodium hypochlorite (12.5%) and 2) the approved feeder/delivery system.

8622

- 64 Ready

- to

- Use Solution 35 Industrial
processes and water systems Pulp and paper mills Pulp and paper mill fresh and
sea water influent systems, and associated cooling water systems and
wastewater treatment systems, pulp, paper and paper board mills systems, Metered 0.3

- 10.0 ppm of residual biocide expressed as total chlorine. 0.54 gallons of Sodium Hypochlorite (12.5%) with 0.22 gallons of end use product End use product is to be used only in conjunction with: 1) an oxidant such as sodium hypochlorite ( 12.5%) and 2) the approved feeder/delivery system. Do not exceed 0.5 pounds per 2205 pounds of dryDocket Number: EPA

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20 nonpotable water systems, starch slurries, and other process water that may
contact food. weight fiber in paper and paperboard components that contact food.

8622

- 75 Technical Chemical 99 This product is for FORMULATING USE ONLY into EPA registered antimicrobials for the following use: recirculating cool water systems, pulp and papermills.

8622

- 76 Soluble Concentrate/Solid 99 Industrial
processes and water systems Recirculating cooling systems Industrial cooling towers, evaporative condensers, heat exchange water towers, influent systems such as flow through filters, industrial water scrubbing systems, brewery pasteurizers, sewage systems (septic tanks, leach fields, tank lines, sewers, lagoons, and sewage effluent water), Metered 0.3

- 5.0 ppm of residual biocide expressed as total chlorine. Recommended dosage may be achieved by mixing 1.5 pounds of chlorine gas (99.9 %) or 1.3 gallons NaOCI (12.5%) with each aqueous solution containing 2.2 pounds of end use product. End use product is to be used only in conjunction with: 1) an oxidant such as sodium hypochlorite (12.5%) or chlorine gas (99.9%) to and 2) the approved f eeder/delivery system.Docket Number: EPA

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21 industrial air

washing systems equipped with a mist eliminator.

8622

- 76 Soluble Concentrate/Solid 99 Industrial
processes and water systems Pulp and paper mills Pulp and paper mill fresh and
sea water influent systems, and associated cooling water systems and
wastewater treatment systems, pulp, paper and paper board mills systems, nonpotable water systems, starch slurries, and other process water that may
contact food. Metered 0.3

- 10.0 ppm of residual biocide expressed as total chlorine. Recommended dosage may be achieved by mixing 1.5 pounds of chlorine gas (99.9%) or 1.3 gallons NaOCI (12.5%) with each aqueous solution containing 2.2 pounds of end use product. En d use product is to be used only in conjunction with: 1) an oxidant such as sodium hypochlorite (12.5%) or chlorine gas (99.9%) to and 2) the approved feeder/delivery system. Do not exceed 0.5 pounds per 2205 pounds of dry weight fiber in paper and paperb oard components that contact food.