Gibberellins Case Number: 4110

043801, 043802, 116902 Product Chemistry

—Registration Review



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460



### 1/1/2013 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

### MEMORANDUM **SUBJECT** : Product Chemistry Scoping Document for the Registration Review o f Chemical Name

. **Registration Review Case #: 4110**  **PC Code: 043801, 043802, 116902**  **CAS Numbers: 77**  **- 06**  **- 5, 125**  **- 67**  **- 7, 8030**  **- 53**  **- 3**  **Chemical Class:**  **Biochem ical**  

### FROM: Sadaf Shaukat , Biologist /s/ 1/1/13

Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P) **TO :**  Menyon Adams , Regulatory Action Leader Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P)

**ACTION REQUESTED** A preliminary

assessment of available information on product chemistry data associated with the biopesticide gibberellins in support of the development of a Registration Review Work Plan.Gibberellins Case Number: 4110

043801, 043802, 116902 

### Introduction The EPA has made the determination that there is adequate information available on gibberellins , including Gibberellic Acid (GA 3 

### ), Gibberellins (GA 4 

### ) and (GA 7 

### ), and Potassium Gibberellate , and does not foresee the need for additional biochemical pesticide product chemistry

data for products that currentl y contain gibberellins as the technical grade active ingredient. Gibberellic Acids are naturall y occurring p lant hormones. They are used in agriculture as plant regulators to stimulate both cell division and cell elongation that affect leaves as well as stems (eventually affecting fruit development and fruit set). The plant regulator, Gibberellic Acid, was initially registered in the United States in 1947 as PROVIDE GROWTH REGULATOR SOLUTION (EPA Reg. No. 275

- 2) for applications to apple trees as a means of controlling fruit russet fungus. Currently there are eighty- one active registrations o f products containing gibb e rellins

. The Agency exempts gibberell ins from the requirement of a tolerance when used as a plant regulator on plants, seeds, or cuttings and on all food commodities af ter harvest (see 40 CFR 180.1098 ). Concerning the product chemistry of gibberellins , all biochemical pesticide data requirements for the technical grade active in gredient have been satisfied and are summarized in Table 2. While no further product chemistry data are necessary

for the products currently

registered, future registrations must adequatel y address all of the biochemical pesticides product chemistry data r equirements.Gibberellins Case Number: 4110

043801, 043802, 116902



### 3 **Table 1. Product Identity and Composition for Gibberellins**  **Case Number** 4110 **Common Name** Gibberellic Acid (GA 3 

### )/Gibberellins (GA 4 

### & GA 7 

### )/Potassium Gibberellate **Chemical Name, IUPAC** Gibberellic Acid (GA 3 

### )/Gibberellins (GA 4 

### & GA 7 

### )/Potassium Gibberellate **Chemical Class** Biochemical **Pesticide Type** Plant Growth Regulator **Year First Registered** 1947 (USDA Registration) **Reregistration Eligibility Decision (RED)**  December 1995 **40 CFR Citation (Tolerance or Exemption From Requirement of a**  **Tolerance 40 CFR Citation (Tolerance or Exemption**  **From Requirement of rance** 40 CFR § 180.1098 **Pesticide Regulatory Action Leader**  Leonard Cole **PC Codes** 043801, 043802, 116902 **CAS Registry Numbers** 77

- 06

- 5, 125

- 67

- 7, 8030

- 53

- 3 **Chemical Structure**Gibberellins Case Number: 4110

043801, 043802, 116902



### 4 **Product Chemistry Summary** The Agency

has conducted a review of the available product chemistry data and information. These data are summarized below. **Table 2. Biochemical Pesticides Product Chemistry Data Requirements for Gibberellins**  **Guideline No. Physical and Chemical**  **Properties Status**  **1 Value**  **MRID /**  **Source 830.1100**  Product Identity and

Com position A Refer to Table 1. RED (Dec. 1995) **830.1200** Description of starting

materials, production and formulation process A CBI 47184703
**830.1400** Discussion of formation of

im purities A CBI 47184703 **830.1700** Preliminary analysis A CBI 44448201 **830.6302** Color A White 45249702, 44448201 **830.6303** Phy sical state A Fine powder 45249702, 44448201 **830.6304** Odor A Odorless 45249702, 44448201 **830.6313** Stability to normal and

elevated temperatures, metals and metal ions A Stable at normal and elevated tem peratures, and in contact with metals/metal ions; Chemically stable following storage @54oC for 14 days; Chemically stable on contact with aluminum, iron, and tin for 14 days; Chemically stable following exposure to artificial sunlight for 24 hrs 44081305, 44264704

**830.7000** pH A 0.1% (w/v) = 3.14 0.5% (w/v) = 2.88 1.0% (w/v) = 2.82 44448201
**830.7050** UV/Visible light absorption A Neutral λ= 270.0 nm; ε= 19580 λ= 209.4 nm; ε= 24385 Acid λ= 278.7 nm; ε= 18998 λ= 206.8 nm; ε= 20800 Base λ= 270.0 nm; ε= 19636 44710204

**830.7200** Melting point/melting range A 205.6

- 224.5 o C 45249702 **830.7220** Boiling point/boiling range N/A Not a liquid at room temperature **830.7300** Density A 0.60 g/ml 44448201 **830.7520** Particle size, fiber length, and

diameter distribution N/A Not a water insoluble or fibrous test substance **830.7550 830.7560**  **830.7570** Partition coefficient (n

Octanol/Water) N/A Partially soluble in water
**830.7840** Water solubility A 70.4% 44448201 **830.7950** Vapor pressure A 0.01 mPa (25 o C)/ 1.3X10 - 13 mm Hg PPDB/Toxnet
1. A= Acceptable. N/A=Not Applicable. N/D=Not DeterminedGibberellins Case Number: 4110

043801, 043802, 116902



### 5 **References** Bade. Product Identity, Manufacturing Process, Formation of Unintentional Ingredients, Gibberellic Acid (GA3). Private Study by Valent BioSciences Corp. Submitted to EPA. MRID 47184703. Pesticide Properties Database, Online . 01/08/2013. http://sitem.herts.ac.uk/aeru/projects/ppdb/index.htm Rojas. Physical and Chemical Properties Characterization of Gibberellin A4/A7 Code 12519, Technical Grade Active Ingredient. Private Study by Abbott Laboratories. Submitted to EPA. MRID 45249702. Toxnet, Online. 01/08/2013. http://toxnet.nlm.nih.gov/cgi

bin/sis/search/f?./temp/~HsGGv C:1:vap United States EPA. Reregistration Eligibility Decision (RED): Gibberellic Acid. December 1995. Zaletal. Product Chemistry

- Phy sical and Chemical Properties of Kaltron Gibberellic Acid

Technical Grade Active Ingredient. Private Study by Z alco Labo ratories, Inc. Submitted to EPA. MRID 44448201.