Gibberellins Case Number: 4110

043801, 043802, 116902

Product Chemistry—Registration Review

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

1/1/2013

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

MEMORANDUM

SUBJECT: Product Chemistry Scoping Document for the Registration Review of Chemical 

Name. 

Registration Review Case #: 4110

PC Code: 043801, 043802, 116902

CAS Numbers: 77-06-5, 125-67-7, 8030-53-3

Chemical Class: Biochemical

FROM: Sadaf Shaukat, Biologist /s/ 1/1/13

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P)

TO: Menyon Adams, Regulatory Action Leader

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P) 

ACTION REQUESTED

A preliminary assessment of available information on product chemistry data associated with the 

biopesticide gibberellins in support of the development of a Registration Review Work Plan.
Gibberellins Case Number: 4110

043801, 043802, 116902

Introduction

The EPA has made the determination that there is adequate information available on gibberellins, 

including Gibberellic Acid (GA3), Gibberellins (GA 4) and (GA 7), and

Potassium Gibberellate, and does not foresee the need for additional biochemical pesticide 

product chemistry data for products that currently contain gibberellins as the technical grade 

active ingredient. Gibberellic Acids are naturally occurring plant hormones. They are used in 

agriculture as plant regulators to stimulate both cell division and cell elongation that affect leaves 

as well as stems (eventually affecting fruit development and fruit set). The plant regulator, 

Gibberellic Acid, was initially registered in the United States in 1947 as PROVIDE GROWTH 

REGULATOR SOLUTION (EPA Reg. No. 275-2) for applications to apple trees as a means of 

controlling fruit russet fungus. Currently there are eighty-one active registrations of products 

containing gibberellins. The Agency exempts gibberellins from the requirement of a tolerance

when used as a plant regulator on plants, seeds, or cuttings and on all food commodities after 

harvest (see 40 CFR 180.1098). 

Concerning the product chemistry of gibberellins, all biochemical pesticide data 

requirements for the technical grade active ingredient have been satisfied and are 

summarized in Table 2. While no further product chemistry data are necessary for the 

products currently registered, future registrations must adequately address all of the 

biochemical pesticides product chemistry data requirements.
Gibberellins Case Number: 4110

043801, 043802, 116902

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Table 1. Product Identity and Composition for Gibberellins

Case Number 4110

Common Name Gibberellic Acid (GA3)/Gibberellins (GA4 & 

GA7)/Potassium Gibberellate

Chemical Name, IUPAC Gibberellic Acid (GA3)/Gibberellins (GA4 & 

GA7)/Potassium Gibberellate

Chemical Class Biochemical

Pesticide Type Plant Growth Regulator

Year First Registered 1947 (USDA Registration)

Reregistration Eligibility Decision

(RED)

December 1995

40 CFR Citation (Tolerance or 

Exemption From Requirement of a 

Tolerance

40 CFR Citation (Tolerance or Exemption 

From Requirement of rance40 CFR § 180.1098

Pesticide Regulatory Action Leader Leonard Cole

PC Codes 043801, 043802, 116902

CAS Registry Numbers 77-06-5, 125-67-7, 8030-53-3

Chemical Structure
Gibberellins Case Number: 4110

043801, 043802, 116902

4

Product Chemistry Summary

The Agency has conducted a review of the available product chemistry data and information. 

These data are summarized below.

Table 2. Biochemical Pesticides Product Chemistry Data Requirements for Gibberellins 

Guideline No. Physical and Chemical 

Properties

Status

1

Value MRID/

Source

830.1100 Product Identity and 

Composition

A Refer to Table 1. RED (Dec. 

1995)

830.1200 Description of starting 

materials, production and 

formulation process

A CBI 47184703

830.1400 Discussion of formation of 

impurities

A CBI 47184703

830.1700 Preliminary analysis A CBI 44448201

830.6302 Color A White 45249702, 

44448201

830.6303 Physical state A Fine powder 45249702, 

44448201

830.6304 Odor A Odorless 45249702, 

44448201

830.6313 Stability to normal and 

elevated temperatures, metals 

and metal ions

A Stable at normal and elevated 

temperatures, and in contact with 

metals/metal ions; Chemically 

stable following storage @54oC 

for 14 days; Chemically stable on 

contact with aluminum, iron, and 

tin for 14 days; Chemically stable 

following exposure to artificial 

sunlight for 24 hrs

44081305, 

44264704

830.7000 pH A 0.1% (w/v) = 3.14

0.5% (w/v) = 2.88

1.0% (w/v) = 2.82

44448201

830.7050 UV/Visible light absorption A Neutral λ= 270.0 nm; ε= 19580

 λ= 209.4 nm; ε= 24385

Acid λ= 278.7 nm; ε= 18998 

 λ= 206.8 nm; ε= 20800

Base λ= 270.0 nm; ε= 19636

44710204

830.7200 Melting point/melting range A 205.6-224.5 oC 45249702

830.7220 Boiling point/boiling range N/A Not a liquid at room temperature

830.7300 Density A 0.60 g/ml 44448201

830.7520 Particle size, fiber length, and 

diameter distribution

N/A Not a water insoluble or fibrous 

test substance

830.7550

830.7560

830.7570

Partition coefficient (nOctanol/Water)N/A Partially soluble in water

830.7840 Water solubility A 70.4% 44448201

830.7950 Vapor pressure A 0.01 mPa (25oC)/ 1.3X10-13 mm 

Hg

PPDB/Toxnet

1. A=Acceptable. N/A=Not Applicable. N/D=Not Determined
Gibberellins Case Number: 4110

043801, 043802, 116902

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References

Bade. Product Identity, Manufacturing Process, Formation of Unintentional Ingredients, 

Gibberellic Acid (GA3). Private Study by Valent BioSciences Corp. Submitted to EPA. MRID 

47184703.

Pesticide Properties Database, Online. 01/08/2013.

http://sitem.herts.ac.uk/aeru/projects/ppdb/index.htm

Rojas. Physical and Chemical Properties Characterization of Gibberellin A4/A7 Code 12519, 

Technical Grade Active Ingredient. Private Study by Abbott Laboratories. Submitted to EPA. 

MRID 45249702.

Toxnet, Online. 01/08/2013. http://toxnet.nlm.nih.gov/cgibin/sis/search/f?./temp/~HsGGvC:1:vap

United States EPA. Reregistration Eligibility Decision (RED): Gibberellic Acid. December 

1995.

Zaletal. Product Chemistry-Physical and Chemical Properties of Kaltron Gibberellic AcidTechnical Grade Active Ingredient. Private Study by Zalco Laboratories, Inc. Submitted to EPA. 

MRID 44448201.