----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Title:                   | A      Phase I-II clinical study of Nimotuzumab (TheraCIM-h-R3) in combination      with external radiotherapy in stage IIb, III, IV NSCLC. (Phase II Portion      only)                                                                                                                                                                                                                                                    |
|--------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Customer:                | YM      BIOSCIENCES INC.                                                                                                                                                                                                                                                                                                                                                                                                    |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| MSA      #:              | YMB07-MSA-17MAY2007                                                                                                                                                                                                                                                                                                                                                                                                         |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| MSA      Expiry Date:    | Project      Completion or Termination                                                                                                                                                                                                                                                                                                                                                                                      |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Proposal      No.:       | YMB08-W04-l5DEC2008-3.0                                                                                                                                                                                                                                                                                                                                                                                                     |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Customer      Reference: | YMB08-W04                                                                                                                                                                                                                                                                                                                                                                                                                   |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Confidentiality:         | Restricted      - Commercial Copyright and Reproduction                                                                                                                                                                                                                                                                                                                                                                     |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
|                     | This      proposal is submitted by Allphase Clinical Research Inc. in response to      the invitation issued by Ryan Sukhoo MD, Clinical Project Manager, YM      BIOSCIENCES INC. It may not be used for any other purposes, reproduced in      whole or in part, nor passed to any organization or person without the      specific permission in writing of the President, Allphase Clinical      Research Services Inc. |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Proposal      Date:      | 16DEC2008                                                                                                                                                                                                                                                                                                                                                                                                                   |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Version:                 | 3.0                                                                                                                                                                                                                                                                                                                                                                                                                         |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Validity:                | 90      days                                                                                                                                                                                                                                                                                                                                                                                                                |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| CRO      Address:        | Allphase      Clinical Research Services Inc.                                                                                                                                                                                                                                                                                                                                                                               |
|                     | 1145      Hunt Club Road, Suite 600                                                                                                                                                                                                                                                                                                                                                                                         |
|                     | Ottawa,      ON Canada K1V 0Y3                                                                                                                                                                                                                                                                                                                                                                                              |
|                     | P:      (613) 228-1990 x 100                                                                                                                                                                                                                                                                                                                                                                                                |
|                     | F:      (6l3) 228-8493                                                                                                                                                                                                                                                                                                                                                                                                      |
|                     | C:      (613) 291-2362                                                                                                                                                                                                                                                                                                                                                                                                      |
|                     | Email:      jsmith@allphaseclinical.com                                                                                                                                                                                                                                                                                                                                                                                     |
|                     |                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Approved      by:        |                                                                                                                                                                                                                                                                                                                                                                                                                        |
|                |                                                                                                                                                                                                                                                                                                                                                                                                                        |   |   |   |
|                     | Jeff      Smith                                                                                                                                                                                                                                                                                                                                                                                                             |   | Date |   |
|                     | President                                                                                                                                                                                                                                                                                                                                                                                                                   |   |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

|   | · | IND/CTA      maintenance; |
|--------|--------|---------------------------|

|   | · | Collaborative      interaction with regulatory authorities and  IRBs; |
|--------|--------|-----------------------------------------------------------------------|

|   | · | Investigator      site selection and feasibilityassessments; |
|--------|--------|--------------------------------------------------------------|

|   | · | Regulatory      document package design (sitelevel); |
|--------|--------|------------------------------------------------------|

|   | · | Contract      and budget preparation, negotiation, and  administration; |
|--------|--------|-------------------------------------------------------------------------|

|   | · | Investigator      meeting organization and sitetraining; |
|--------|--------|----------------------------------------------------------|

|   | · | CRA      resourcing, mentoring, and co-monitoring  support; |
|--------|--------|-------------------------------------------------------------|

|   | · | Monitoring      report review; |
|--------|--------|--------------------------------|

|   | · | SAE      reporting coordination; |
|--------|--------|----------------------------------|

|   | · | Coordination      of site/ vendor/ client communications;and |
|--------|--------|--------------------------------------------------------------|

|   | · | Managing      client expectations for on-time and on-budget  performance. |
|--------|--------|---------------------------------------------------------------------------|

|   | · | Site      initiation, routine monitoring, andclose-out; |
|--------|--------|---------------------------------------------------------|

|   | · | Site      personnel training, mentoring, andguidance; |
|--------|--------|-------------------------------------------------------|

|   | · | Assessing      protocol compliance and dataintegrity; |
|--------|--------|-------------------------------------------------------|

|   | · | Regulatory      document review; |
|--------|--------|----------------------------------|

|   | · | Pharmacy      training and drug accountability;and |
|--------|--------|----------------------------------------------------|

|   | · | Ensuring      GCP, consenting, confidentiality, and safety requirements are      met. |
|--------|--------|---------------------------------------------------------------------------------------|

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

|   | · | Evaluation      and auditing of our qualityprocesses: |
|--------|--------|-------------------------------------------------------|

|   | o | Vendor      qualification and due diligence audits (CROs, central IRBs,      clinical/diagnostic laboratories, centralized ECG/PFT readers, clinical      data management, clinical supplies  distributors); |
|--------|---|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | o | Clinical      investigator site audits; |
|--------|---|-----------------------------------------|

|   | o | Clinical      data management process audits; |
|--------|---|-----------------------------------------------|

|   | o | Clinical      study report and regulatory submission document  audits; |
|--------|---|------------------------------------------------------------------------|

|   | o | Systems      audits (pharmacovigilance and drug safety reporting, computer system      validation documentation compliance, clinical research      operations). |
|--------|---|-----------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | Standard      Operating Procedure (SOP) and policies  development: |
|--------|--------|--------------------------------------------------------------------|

|   | o | Clinical      research SOP gap analyses and needsassessment; |
|--------|---|--------------------------------------------------------------|

|   | o | Facilitation      of SOP/policies development, approval process, distribution and training      activities; |
|--------|---|-------------------------------------------------------------------------------------------------------------|

|   | o | Collaborative      design and writing of customized SOPs and  policies. |
|--------|---|-------------------------------------------------------------------------|

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

|   | · | Statistical      Design and Analysis; |
|--------|--------|---------------------------------------|

|   | · | Therapeutically      aligned Medical Monitoring; |
|--------|--------|--------------------------------------------------|

|   | · | DSMB; |
|--------|--------|-------|

|   | · | Clinical      laboratory services; |
|--------|--------|------------------------------------|

|   | · | Investigational      Product Distribution; |
|--------|--------|--------------------------------------------|

|   | · | IVRS; |
|--------|--------|-------|

|   | · | Home      Health Care network; |
|--------|--------|--------------------------------|

|   | · | Ethics      Review Boards; |
|--------|--------|----------------------------|

|   | · | Translation      services; |
|--------|--------|----------------------------|

|   | · | Global      provider network; |
|--------|--------|-------------------------------|

|   | · | DocStorage.ca |
|--------|--------|---------------|

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Therapeutic      Area   |   | Indications                                                                                                                                                                                              |
|-------------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Oncology                |   | BrainBreastHead      and NeckOvarianRenal      Cell CarcinomaSmall      Cell LungColorectalPediatric      GliomaBone      Marrow TransplantReduction      of Neurotoxicity                               |
| Allergy/Respiratory     |   | AsthmaChronic      Obstructive Pulmonary DiseasePerennial      Allergic RhinitisSeasonal      Allergic Rhinitis                                                                                          |
| Cardiovascular          |   | Atrial      FibrillationDeep      Vein ThrombosisIntermittent      ClaudicationPulmonary      EmbolismDyslipidemiaAtherosclerosisVenous      Leg UlcersHypercholesterolemia                              |
| CNS                     |   | Amytrophic      Lateral SclerosisAlzheimer’s      DiseaseDepressionMultiple      SclerosisSmoking      CessationInsomniaStroke                                                                     |
| Endocrinology           |   | DiabetesObesity                                                                                                                                                                                          |
| Infectious      Disease |   | HepatitisHIV                                                                                                                                                                                             |
| Other                   |   | Alpha-1      Antitrypsin DeficiencyPrimary      Immune DeficiencyPost-op      Pediatric Aggregation InhibitionThrombotic      Thrombocytopenic PurpuraDilutional      HyponatremiaAtopic      Dermatitis |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Therapeutic Area                |   | Phase |   | # of Sites |   | # of Subjects |
|--------------------------------------|--------|-------|--------|----------------------|--------|-------------------------|
| Small      Cell Lung Cancer          |   | I/II  |   | 5                    |   | 48                      |
| Advanced      Breast Cancer          |   | II    |   | 5                    |   | 30                      |
| Metastatic      Renal Cell Carcinoma |   | II    |   | 1                    |   | 5                       |
| Metastatic      Breast Cancer        |   | II    |   | 4                    |   | 37                      |
| Squamous      Cell Carcinoma         |   | II    |   | 6                    |   | 20                      |
| Squamous      Cell Carcinoma         |   | II    |   | 6                    |   | 10                      |
| Pediatric      Brain Tumors          |   | I     |   | I                    |   | 19                      |
| Ovarian      Cancer                  |   | II    |   | 7                    |   | 40                      |
| Colorectal      Cancer               |   | II    |   | 14                   |   | 61                      |
| Multiple      Myeloma                |   | IIb   |   | 10                   |   | 50                      |
| Multiple      Myeloma                |   | III   |   | 10                   |   | 50                      |
| Pediatric      Glioma                |   | II    |   | 6                    |   | 44                      |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Technical      Contact                  | Administrative      Contact               |
|-----------------------------------------|-------------------------------------------|
| Wendy      Kirby, RN.,                  | Anne      Gamache                         |
| Sr.      Project Manager                | Project      Analyst                      |
| Allphase      Clinical Research Inc.    | Allphase      Clinical Research Inc.      |
| 1145      Hunt Club K1V 0Y3             | 1145      Hunt Club K1V 0Y3               |
| Tel:      613-228-1990 x 117            | Tel:      613-228-1990 x 136              |
| Fax:      613-228-8493                  | Fax:      613-228-8493                    |
| Cell:      613-808-4768                 | Email:      agamache@allphaseclinical.com |
| Email:      wkerby@allphaseclinical.com |                                      |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Related Area                 |         | Title of SOP                                                                                     |         | Effective Date |
|-----------------------------------|--------------|------------------------------------------------------------------------------------------------------------|--------------|---------------------|
| Quality      Assurance (QA)       |         |                                                                                                       |         |                |
| QA      006.01                    |         | Investigator      Site Audits                                                                              |         | 03-DEC-2007         |
| QA      008.00                    |         | Fraud      or Scientific Misconduct                                                                        |         | 15-JUN-2007         |
| Clinical      Research (CR or CO) |         |                                                                                                       |         |                |
| CR      100.00                    |         | Preparing,      Maintaining and archiving of the Trial Master File                                         |         | 27-MAR-2006         |
| CR      104.00                    |         | Investigator      Site Selection                                                                           |         | 27-MAR-2006         |
| CO      105.01                    |         | Translation      of Clinical Study Documents                                                               |         | 07-NOV-2008         |
| CO      106.01                    |         | Investigator      Meetings                                                                                 |         | 18-SEP-2008         |
| CR      107.00                    |         | Investigator      Financial Agreements                                                                     |         | 15-JUN-2006         |
| CR      108.00                    |         | Site      Initiation Visit                                                                                 |         | 01-JUN-2006         |
| CO      109.03                    |         | Interim      Monitoring Visit                                                                              |         | 31-OCT-2007         |
| CR      110.00                    |         | Close-Out      Visit                                                                                       |         | 10-JUN-2006         |
| CO      111.01                    |         | Source      Document versus Case Report Form                                                               |         | 06-MAY-2008         |
| CO      112.00                    |         | Source      Data Verification and Case Report Form Review                                                  |         | 18-JUL-2008         |
| CO      113.01                    |         | Protocol      Deviations                                                                                   |         | 11-JUL-2008         |
| CO      114.01                    |         | Recording      and Reporting Adverse Events                                                                |         | 06-AUG-2008         |
| CO      115.01                    |         | The      Archiving and Shipping of the Trial Master File                                                   |         | 09-SEP-2008         |
| CO      118.00                    |         | Premature      Termination or Suspension of a Clinical Trial                                               |         | 29-JUL-2008         |
| CO      119.00                    |         | Data      Clarification                                                                                    |         | 03-APR-2008         |
| CO      120.00                    |         | Investigational      Product Accountability                                                                |         | 09-OCT-2008         |
| CO      121.00                    |         | Site      Transfer between Clinical Research Associates                                                    |         | 12-NOV-2008         |
| CO      122.00                    |         | Monitoring      Plan                                                                                       |         | 24-JUN-2008         |
| CO      123.00                    |         | Distribution      and Tracking of Investigator’s Brochure                                            |         | 24-JUN-2008         |
| CO      124.00                    |         | TMF      Document Retrieval                                                                                |         | 09-SEP-2008         |
| CO      126.00                    |         | Data      safety Monitoring Boards                                                                         |         | 19-JAN-2009         |
| Scientific      Affairs (SA)      |         |                                                                                                       |         |                |
| SA      600.01                    |         | Clinical      Study Report                                                                                 |         | 19-NOV-2008         |
| SA      601.01                    |         | Statistical      Analysis Plan                                                                             |         | 19-NOV-2008         |
| Drug      Safety (DS)             |    | Recording      and Reporting of Serious Adverse Events and Reporting of Safety      Information Externally |    | 10-NOV-2006         |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Protocol                                         |   |   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
|--------------------------------------------------|--------|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Sponsor                                          |   |   |   | YM      BIOSCIENCES INC.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| Protocol      Number                             |   |   |   | YMB      1000-010                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| Protocol      Version                            |   |   |   | November      18th,      2008 - version 1.0                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
| Drug                                             |   |   |   | Nimotuzumab      (TheraCIM h-R3) from CIMYM                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
| Indication                                       |   |   |   | Stage      IIb,III,IV non-small cell lung cancer                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
| Phase                                            |   |   |   | III                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
| Title                                            |   |   |   | A      Phase I-II clinical study of Nimotuzumab (TheraCIM-h-R3) in combination      with external radiotherapy in stage IIb, III, IV NSCLC. (Phase II Portion      only)                                                                                                                                                                                                                                                                                                                                                                                                                               |
| Short      Title                                 |   |   |   | TBD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
| Objectives      for Phase I component            |   |   |   | Primary: To evaluate the      safety and feasibility of the administration of nimotuzumab with      palliative radiation in patients who are unsuitable for radical therapy      (curative intent chemo radiation)                                                                                                                                                                                                                                                                                                                                                                                     |
| Objectives      for Phase II component           |   |   |   | Primary: 1) To assess      the overall survival (median survival time) in patients treated with      nimotuzamab in combination with palliative radiation vs radiation alone.      2) To assess the local and systemic response rates produced by nimotuzamab      in combination with palliative radiation vs radiation alone in patients      with NSCLC stage IIb, III, and IV. Stage II/able for radical therapy      (either radiation or chemo radiation). 3) To evaluate quality of life in      patients receiving nimotuzamab in combination with radiation compared to      radiation alone. |
| Sites      & Start Up Meetings               |   |   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| No.      of Local Investigator Meetings          |   | 1      |   | Ottawa                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |
| Local      Investigator Meeting Attendance (hrs) |   | 16     |   | 2      days; 1 day workshop with coordinators                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |
| PM                                               |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| CRA                                              |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| Quality      Assurance (ACE)                     |   | 0      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| COA                                              |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| Medical      Monitor                             |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| Local      Kick off Meeting                      |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| PM                                               |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| CRA                                              |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| COA                                              |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| Medical      Monitor                             |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| Protocol      Review Process                     |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| PM                                               |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| Director      of Scientific Affairs              |   | 1      |   | No      = 0; Yes = 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| CRA                                              |   | 1      |   | No      = 0; Yes = 1                                                                                                                        |
|--------------------------------------------------|--------|--------|--------|---------------------------------------------------------------------------------------------------------------------------------------------|
| COA                                              |   | 1      |   | No      = 0; Yes = 1                                                                                                                        |
| Medical      Monitor                             |   | 1      |   | No      = 0; Yes = 1                                                                                                                        |
| Mid      Study Local Team Meeting                |   | 1      |   | No      = 0; Yes = 1                                                                                                                        |
| PM                                               |   | 1      |   | No      = 0; Yes = 1                                                                                                                        |
| CRA                                              |   | 1      |   | No      = 0; Yes = 1                                                                                                                        |
| COA                                              |   | 1      |   | No      = 0; Yes = 1                                                                                                                        |
| Medical      Monitor                             |   | 1      |   | No      = 0; Yes = 1                                                                                                                        |
| #      of Treatment Groups                       |   | 1      |   | 2      arms in phase II                                                                                                                     |
| Local      or Central IRB                        |   | Local  |   |                                                                                                                                        |
| #      of Sites to be Managed by Allphase        |   | 20     |   | All      Canadian                                                                                                                           |
| #      of Sites to be Monitored by Allphase      |   | 20     |   |                                                                                                                                        |
| Percentage      of Subjects to be Monitored      |   | 100    |   |                                                                                                                                        |
| Feasibility      Survey                          |   | Y      |   | Y/N                                                                                                                                         |
| #      of Sites for Feasibility Survey           |   | 20     |   | YMB      responsibility - Allphase to Assist                                                                                                |
| #      of Sites Selection Visits (CRA)           |   | 0      |   | TBD                                                                                                                                         |
| #      of Sites Selection Visits (PM)            |   | 0      |   |                                                                                                                                        |
| #      of Sites Initiation Visits (CRA)          |   | 20     |   |                                                                                                                                        |
| #      of Sites Initiation Visits (PM)           |   | 4      |   | One      per CRA                                                                                                                            |
| Est.      # of Monitoring Hrs/non-evaluable pt.  |   | 6      |   |                                                                                                                                        |
| Est.      # of Monitoring Hrs/screen failure pt. |   | 1      |   | Assuming      minimal data collection                                                                                                       |
| Est.      # of Monitoring Hrs/Completed CRF      |   | 20     |   |                                                                                                                                        |
| Est.      # of Hrs/Visit Report                  |   | 5      |   |                                                                                                                                        |
| Estimated      # of Monitoring Hours             |   | 2573   |   |                                                                                                                                        |
| Estimated      # of Monitoring Days              |   | 368    |   |                                                                                                                                        |
| Estimated      # of Monitoring Visits            |   | 258    |   | Assume      30% of visits can be multi-day visits considering both projects (1000-10      & 1000-08-0202) having many of the same sites |
| Estimated      % of 1 day Monitoring Visits      |   | 70%    |   |                                                                                                                                        |
| Estimated      Monitoring Frequency              |   | 6      |   | Weeks                                                                                                                                       |
| Estimated      # of CRAs                         |   | 4      |   | Regionally      based in Canada                                                                                                             |
| Estimated      # of Close-out Visits             |   | 20     |   |                                                                                                                                        |
| Subjects                                         |   |   |   |                                                                                                                                        |
| Number      of Subjects Randomized locally       |   | 128    |   |                                                                                                                                        |
| Screen      Failure Rate                         |   | 10%    |   |                                                                                                                                        |
| Drop      Out Rate (once Randomized)             |   | 0%     |   |                                                                                                                                        |
| #      of Subjects Evaluable locally             |   | 128    |   |                                                                                                                                        |
| #      of Subjects Screened locally              |   | 141    |   |                                                                                                                                        |
| Enrolment      Period                            |   | 82     |   |                                                                                                                                        |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Duration      of Each Subject                          |   | 52     |   |                                                  |
|--------------------------------------------------------|--------|--------|--------|-------------------------------------------------------|
| Total      Study Duration (all subjects)               |   | 134    |   |                                                  |
| Project      Administration                            |   |   |   |                                                  |
| #      PMs for project                                 |   | 1      |   | No      = 0; Yes = 1                                  |
| #      COAs for project                                |   | 1      |   |                                                  |
| #      of collaborating CROs                           |   | 0      |   |                                                  |
| Total      Study Duration (PM)                         |   | 148    |   | weeks                                                 |
| Estimated      # PM hours/week/site                    |   | 0.5    |   |                                                  |
| Estimated      # PM hours/week                         |   | 10     |   |                                                  |
| Estimated      # CRA Admin Hrs/week/site               |   | 0.5    |   |                                                  |
| Estimated      # CRA Admin Hrs/week                    |   | 10     |   |                                                  |
| Estimated      # COA Admin Hrs/week/site               |   | 0.75   |   |                                                  |
| Estimated      # COA Admin Hrs/week                    |   | 15     |   |                                                  |
| Estimated      # Doc Man. Admin Hrs/Site/Week          |   | 0.5    |   |                                                  |
| Estimated      # Doc Man. Admin Hrs/Week               |   | 10     |   |                                                  |
| Team      Teleconferences                              |   | 2      |   | 1=Weekly;      2=bi-weekly, 4=monthly                 |
| #      of Teleconferences                              |   | 74     |   |                                                  |
| Estimated      # Hrs/Teleconference/CRA                |   | 0.75   |   |                                                  |
| PM      Teleconferences (with Sponsor)                 |   | 1      |   | 1=Weekly;      2=bi-weekly, 4=monthly                 |
| Number      of PM Teleconferences (Sponsor)            |   | 148    |   |                                                  |
| Estimated      # Hrs/Teleconference (Sponsor)          |   | 1      |   |                                                  |
| PM      Ad hoc visits/quarter                          |   | 1      |   |                                                  |
| Estimated      # of PM Ad-Hoc Visits                   |   | 12     |   |                                                  |
| Estimated      # of Co-Visits by PM                    |   | 4      |   |                                                  |
| Medical      Writing                                   |   |   |   |                                                  |
| Medical      Writing Research and Therapeutic Training |   | 0      |   | No      = 0; Yes = 1                                  |
| Regulatory      Affairs                                |   |   |   |                                                  |
| Pre      CTA Meeting with Health Canada                |   | 0      |   | No      = 0; Yes = 1                                  |
| Submission      to Health Canada                       |   | 0      |   | No      = 0; Yes = 1                                  |
| Estimated      # of HC Amendments                      |   | 0      |   |                                                  |
| Safety                                                 |   |   |   |                                                  |
| Medical      Oversight by Allphase?                    |   | 1      |   | No      = 0; Yes = 1                                  |
| #      of subjects for Safety                          |   | 128    |   |                                                  |
| Estimated      Percentage of SAEs                      |   | 50%    |   |                                                  |
| Estimated      # of SAEs                               |   | 64     |   |                                                  |
| Estimated      Percentage of Reportable SAEs           |   | 20%    |   | Percentage      of SAEs requiring regulatoryreporting |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Estimated      # of Reportable SAEs                           |   | 13     |   |                                                                                                       |
|---------------------------------------------------------------|--------|--------|--------|------------------------------------------------------------------------------------------------------------|
| Teleconferences                                               |   | 13     |   | 1=Weekly;      2=bi-weekly, 4=monthly, 8=bi-monthly, 13=quarterly                                          |
| #      of Teleconferences with Sponsor                        |   | 11     |   |                                                                                                       |
| Management      of DSMB                                       |   | 1      |   | No      = 0; Yes = 1                                                                                       |
| #      of DSMB meetings                                       |   | 3      |   |                                                                                                       |
| Estimated      AEs/Randomized Subject                         |   | 10     |   |                                                                                                       |
| Estimated      Medical terms for Manual Coding/Subject        |   | 10     |   |                                                                                                       |
| Data      Management                                          |   |   |   |                                                                                                       |
| Data      Management Involvement?                             |   | 0      |   | No      = 0; Yes = 1                                                                                       |
| BioStatistics                                                 |   |   |   |                                                                                                       |
| Biostatistics      Involvement?                               |   | 0      |   | No      = 0; Yes = 1                                                                                       |
| Quality      Assurance                                        |   |   |   |                                                                                                       |
| Site      Audits                                              |   | 3      |   |                                                                                                       |
| TMF      Audit                                                |   | 0      |   |                                                                                                       |
| Vendor      Management                                        |   |   |   |                                                                                                       |
| Central      Lab Managed by Allphase?                         |   | 0      |   | No      = 0; Yes = Number of labs                                                                          |
| Imaging      Lab Managed by Allphase?                         |   | 0      |   | No      = 0; Yes = Number if labs                                                                          |
| Investigational      Product Distributor Managed by Allphase? |   | 0      |   | No      = 0; Yes = 1                                                                                       |
| SOP                                                           |   |   |   |                                                                                                       |
| Allphase      SOPs to be used?                                |   | 1      |   | No      = 0; Yes = 1 (expand group)                                                                        |
| Allphase      Forms?                                          |   | 1      |   | No      = 0; Yes = 1 (expand group)                                                                        |
| Services      Requested                                       |   |   |   |                                                                                                       |
|                                                          |   |   |   | Regulatory                                                                                                 |
|                                                          |   | YMB    |   | CTA      prep, submission and maintenance                                                                  |
|                                                          |   |   |   | Project      Management                                                                                    |
|                                                          |   | YMB    |   | Site      Contract Negotiation                                                                             |
|                                                          |   | ACR    |   | Site      Payment Facilitation                                                                             |
|                                                          |   | ACR    |   | Regulatory      Document Collection                                                                        |
|                                                          |   | ACR    |   | Trial      Master File Set-up & Maintenance                                                            |
|                                                          |   | ACR    |   | ICF      Preparation & Translation                                                                     |
|                                                          |   | ACR    |   | IRB      preparations and submissions - central IRB; or assistance with the      submissions if local IRB. |
|                                                          |   | YMB    |   | Site      Identification                                                                                   |
|                                                          |   | ACR    |   | Multi-site      Management                                                                                 |
|                                                          |   | ACR    |   | CRA      Management                                                                                        |
|                                                          |   | ACR    |   | Teleconference      and Project Updates                                                                    |
|                                                          |   | YMB    |   | Vendor      Management (if applicable)                                                                     |
|                                                          |   | ACR    |   | General      Administration                                                                                |
|                                                          |   |   |   | Investigator      Meeting - North America                                                                  |
|                                                          |   | ACR    |   | Attendance                                                                                                 |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

|   |         | ACR    |         | Planning      & Execution                   |
|--------|--------------|--------|--------------|-------------------------------------------------|
|   |         | ACR    |         | Presentations                                   |
|   |         | ACR    |         | Travel      Arrangements for Attendees          |
|   |         |   |         | Clinical      Monitoring                        |
|   |         | ACR    |         | Pre-Study      Visits (new sites only)          |
|   |         | ACR    |         | Site      Initiation                            |
|   |         | ACR    |         | Interim      Monitoring & Site management   |
|   |         | ACR    |         | Site      Close Out                             |
|   |         |   |         | Safety                                          |
|   |         | ACR    |         | Safety      Plan                                |
|   |         | ACR    |         | CIOMS/MedWatch      report prep                 |
|   |         | ACR    |         | SAE      alert reporting to authorities         |
|   |         |   |         | Data      Management/Biostatistics              |
|   |         | YMB    |         | CRF      Design & Build                     |
|   |         | YMB    |         | DM      System Set Up (include edit checks)     |
|   |         | YMB    |         | Data      Validation and Review CRFs            |
|   |         | YMB    |         | Data      Query                                 |
|   |         | YMB    |         | Coding      AE & Medications                |
|   |         | YMB    |         | Interim      Analysis Plan                      |
|   |         | YMB    |         | Final      Analysis Plan                        |
|   |         | YMB    |         | Randomization      Services                     |
|   |         | ACR    |         | Medical      Monitoring                         |
|   |         |   |         | Data      Monitoring Committee                  |
|   |         | ACR    |         | Establish      Committee and Organize Meetings  |
|   |         |   |         | Medical      Writing                            |
|   |         | YMB    |         | Protocol      Development                       |
|   |         | YMB    |         | Interim      & Final Clinical Study Reports |
|   |         | YMB    |         | Manuscripts                                     |
|   |         |   |         | Quality      Assurance                          |
|   |         | ACR    |         | GCP      Investigator/Site/Vendor Audit         |
|   |         | TBD    |         | QA      Audit of Clinical Database              |
|   |    | TBD    |    | QA      Audit of Clinical StudyReport           |

| Activity                       |   | Date of Completion |
|--------------------------------|--------|------------------------------|
| Executed      LOI              |   | Dec-08                       |
| Fully      Executed Contract   |   | Dec-08                       |
| Kick-off      Meeting          |   | Jan-08                       |
| Site      Selection            |   | Jan-08                       |
| IRB      Submissions           |   | Jan-09                       |
| Investigator      Agreements   |   | Jan-09                       |
| Investigator      Meeting      |   | Feb-09                       |
| First      SIV                 |   | Mar-09                       |
| First      Subject First Visit |   | Mar-09                       |
| Last      Subject First Visit  |   | Sep-10                       |

| Last      Subject Last Visit     |         | Sep-11 |
|----------------------------------|--------------|--------|
| Data      Base Lock              |         | Nov-11 |
| Final      Close-Out Visit       |         | Nov-11 |
| Final      Clinical Study Report |    | Dec-11 |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Start-Up      Duration         |   | 9   |
|--------------------------------|--------|-----|
| Enrolment                      |   | 82  |
| Treatment      period          |   | 52  |
| Close      Out (DBL to CSR)    |   | 5   |
| Total      Subject Duration    |   | 134 |
| Total      Study Duration (PM) |   | 148 |
| Data      Management Duration  |   | 138 |

| Allphase Role |   | Allphase Resource                |   | Hourly Rate (CDN) |   |
|--------------------|--------|---------------------------------------|--------|-----------------------------|--------|
| DE                 |   | Data      Entry Personnel             |   | $                           | 65     |   |
| DOC                |   | Document      Management              |   | $                           | 75     |   |
| COA                |   | Clinical      Operations Associate    |   | $                           | 75     |   |
| CRA                |   | Clinical      Research Associate      |   | $                           | 90     |   |
| LCRA               |   | Lead      Clinical Research Associate |   | $                           | 95     |   |
| DM                 |   | Data      Manager                     |   | $                           | 100    |   |
| MW                 |   | Medical      Writing                  |   | $                           | 100    |   |
| PM                 |   | Project      Manager                  |   | $                           | 100    |   |
| RA                 |   | Regulatory      Affairs               |   | $                           | 100    |   |
| DS                 |   | Drug      Safety                      |   | $                           | 100    |   |
| QA                 |   | Quality      Assurance Auditor        |   | $                           | 100    |   |
| DIR                |   | Director      Scientific Affairs      |   | $                           | 120    |   |
| BIO                |   | Biostatistician                       |   | $                           | 130    |   |
| ACE                |   | Trainer                               |   | $                           | 150    |   |
| MMD                |   | Medical      Monitor Data Management  |   | $                           | 200    |   |
| MM                 |   | Medical      Monitor                  |   | $                           | 350    |   |

| List of Tasks                              |   | YMB    |   | Allphase |   | ADM    |   | TaskHours |   | Units  |   | TotalHours |   | Resp   |   |
|------------------------------------------------------|--------|--------|--------|----------|--------|--------|--------|-----------|--------|--------|--------|------------|--------|--------|--------|
| Pre-Study      Activities                            |   |   |   |     |   |   |   |      |   |   |   |       |   |   |   |
| Project      Feasibility Study                       |   |   |   |     |   |   |   |      |   |   |   |       |   |   |   |
| Identify      sites                                  |   | X      |   |     |   |   |   |      |   |   |   |       |   |   |   |
| Contact      sites                                   |   | X      |   |     |   |   |   |      |   |   |   |       |   |   |   |
| Draft      CDA for sites                             |   | X      |   |     |   |   |   |      |   |   |   |       |   |   |   |
| Develop      Feasibility Survey                      |   | (X)    |   | X        |   |   |   | 4         |   | 1      |   | 4          |   | PM     |   |
| Distribute      CDA to sites                         |   | X      |   |     |   |   |   |      |   |   |   |       |   |   |   |
| Distribute      Feasibility to sites                 |   | X      |   |     |   |   |   |      |   |   |   |       |   |   |   |
| Collect      and review CDA/Feasibilities from sites |   | X      |   |     |   |   |   |      |   |   |   |       |   |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Review      Feasibilities from sites                                                     |   | (X)    |   | X      |   |   |   | 0.5    |   | 20     |   | 10     |   | PM     |   |
|------------------------------------------------------------------------------------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|
| Compile      Feasibility Report                                                          |   | X      |   | X      |   |   |   | 8      |   | 1      |   | 8      |   | PM     |   |
| Protocol      Development                                                                |   | X      |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Protocol      Ammendments (if required)                                                  |   | X      |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Compilation      & update IB                                                         |   | X      |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Kick-off      meeting                                                                    |   | X      |   | X      |   |   |   |   |   |   |   |   |   |   |   |
| PM      attendance                                                                       |   |   |   |   |   |   |   | 8      |   | 1      |   | 8      |   | PM     |   |
| PM      travel time                                                                      |   |   |   |   |   |   |   | 0      |   | 0      |   | 0      |   | PM     |   |
| CRA      attendance                                                                      |   |   |   |   |   |   |   | 8      |   | 4      |   | 32     |   | CRA    |   |
| CRA      travel time (average)                                                           |   |   |   |   |   |   |   | 8      |   | 4      |   | 32     |   | CRA    |   |
| COA      attendance                                                                      |   |   |   |   |   |   |   | 8      |   | 1      |   | 8      |   | COA    |   |
| COA      travel time                                                                     |   |   |   |   |   |   |   | 0      |   | 0      |   | 0      |   | COA    |   |
| Medical      Monitor attendance                                                          |   |   |   |   |   |   |   | 4      |   | 1      |   | 4      |   | MM     |   |
| Medical      Monitor travel time                                                         |   |   |   |   |   |   |   | 3      |   | 1      |   | 3      |   | MM     |   |
| International      Kick-Off Meeting                                                      |   | N/A    |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Mid      Study Local Team Meeting                                                        |   | X      |   | X      |   |   |   |   |   |   |   |   |   |   |   |
| PM      attendance                                                                       |   |   |   |   |   |   |   | 8      |   | 1      |   | 8      |   | PM     |   |
| PM      travel time                                                                      |   |   |   |   |   |   |   | 0      |   | 0      |   | 0      |   | PM     |   |
| CRA      attendance                                                                      |   |   |   |   |   |   |   | 8      |   | 4      |   | 32     |   | CRA    |   |
| CRA      travel time (average)                                                           |   |   |   |   |   |   |   | 8      |   | 4      |   | 32     |   | CRA    |   |
| COA      attendance                                                                      |   |   |   |   |   |   |   | 8      |   | 1      |   | 8      |   | COA    |   |
| COA      travel time                                                                     |   |   |   |   |   |   |   | 0      |   | 0      |   | 0      |   | COA    |   |
| Medical      Monitor attendance                                                          |   |   |   |   |   |   |   | 4      |   | 1      |   | 4      |   | MM     |   |
| Medical      Monitor travel time                                                         |   |   |   |   |   |   |   | 3      |   | 1      |   | 3      |   | MM     |   |
| Protocol      Review Process                                                             |   | (X)    |   | X      |   |   |   |   |   |   |   |   |   |   |   |
| PM                                                                                       |   |   |   |   |   |   |   | 4      |   | 1      |   | 4      |   | PM     |   |
| Director      Scientific Affairs                                                         |   |   |   |   |   |   |   | 4      |   | 1      |   | 4      |   | DIR    |   |
| CRA                                                                                      |   |   |   |   |   |   |   | 4      |   | 4      |   | 16     |   | CRA    |   |
| COA                                                                                      |   |   |   |   |   |   |   | 4      |   | 1      |   | 4      |   | COA    |   |
| Medical      Monitor                                                                     |   |   |   |   |   |   |   | 4      |   | 1      |   | 4      |   | MM     |   |
| Regulatory      Management – study                                                 |   | N/A    |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Vendor      Management                                                                   |   | N/A    |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Local      Investigator Meeting                                                          |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Identify      location and conduct preliminary investigation of costs;      reservations |   | (X)    |   | X      |   |   |   | 8      |   | 1      |   | 8      |   | COA    |   |
| Organize      travel & hotel for study team                                          |   | (X)    |   | X      |   |   |   | 12     |   | 1      |   | 12     |   | COA    |   |
| Plan      and organize IM                                                                |   | (X)    |   | X      |   |   |   | 40     |   | 1      |   | 40     |   | PM     |   |
| Teleconferences      – PM                                                          |   | (X)    |   | X      |   |   |   | 1      |   | 5      |   | 5      |   | PM     |   |
| Teleconferences      – COA                                                         |   | (X)    |   | X      |   |   |   | 1      |   | 5      |   | 5      |   | COA    |   |
| Prepare      agenda                                                                      |   | (X)    |   | X      |   |   |   | 4      |   | 1      |   | 4      |   | PM     |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Prepare      presentations                                                            |   | (X)    |   | X      |   |   |   | 16     |   | 1      |   | 16     |   | PM     |   |
|---------------------------------------------------------------------------------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|
| Design      Investigator Meeting materials                                            |   | (X)    |   | X      |   |   |   | 12     |   | 1      |   | 12     |   | PM     |   |
| Prepare      Investigator Meeting materials                                           |   | (X)    |   | X      |   |   |   | 24     |   | 1      |   | 24     |   | COA    |   |
| Prepare      welcome letters, name tags, materials                                    |   | (X)    |   | X      |   |   |   | 16     |   | 1      |   | 16     |   | COA    |   |
| Attendance      &  presentations at Meeting                             |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| PM      prep                                                                          |   |   |   | X      |   |   |   | 2      |   | 1      |   | 2      |   | PM     |   |
| PM      travel                                                                        |   |   |   | X      |   |   |   | 2      |   | 1      |   | 2      |   | PM     |   |
| PM      Presentation & Attendance                                                 |   |   |   | X      |   |   |   | 16     |   | 1      |   | 16     |   | PM     |   |
| CRA      prep                                                                         |   |   |   | X      |   |   |   | 2      |   | 4      |   | 8      |   | CRA    |   |
| CRA      travel                                                                       |   |   |   | X      |   |   |   | 8      |   | 4      |   | 32     |   | CRA    |   |
| CRA      attendance                                                                   |   |   |   | X      |   |   |   | 16     |   | 4      |   | 64     |   | CRA    |   |
| ACE      Trainer prep                                                                 |   |   |   | N/A    |   |   |   |   |   |   |   |   |   | QA     |   |
| ACE      Trainer travel                                                               |   |   |   | N/A    |   |   |   |   |   |   |   |   |   | QA     |   |
| ACE      Trainer presentation & attendance                                        |   |   |   | N/A    |   |   |   |   |   |   |   |   |   | QA     |   |
| COA      prep & oversight                                                         |   |   |   | X      |   |   |   | 24     |   | 1      |   | 24     |   | COA    |   |
| COA      travel                                                                       |   |   |   | X      |   |   |   | 2      |   | 1      |   | 2      |   | COA    |   |
| COA      attendance                                                                   |   |   |   | X      |   |   |   | 16     |   | 1      |   | 16     |   | COA    |   |
| Medical      Monitor prep                                                             |   |   |   | X      |   |   |   | 2      |   | 1      |   | 2      |   | MM     |   |
| Medical      Monitor travel                                                           |   |   |   | X      |   |   |   | 2      |   | 1      |   | 2      |   | MM     |   |
| Medical      Monitor Presentation & Attendance                                    |   |   |   | X      |   |   |   | 8      |   | 1      |   | 8      |   | MM     |   |
| Ethics                                                                                |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Preparation      of ICF template                                                      |   | X      |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Customization      of ICF (PIPEDA)                                                    |   |   |   | X      |   |   |   | 1      |   | 20     |   | 20     |   |   |   |
| Preparation      of other subject materials                                           |   | (X)    |   | X      |   |   |   | 12     |   | 1      |   | 12     |   | PM     |   |
| Assist      sites with submissions                                                    |   | (X)    |   | X      |   |   |   | 1      |   | 20     |   | 20     |   | PM     |   |
| IRB      approval review & action if needed                                       |   | (X)    |   | X      |   |   |   | 1      |   | 20     |   | 20     |   | PM     |   |
| Translation      of ICF & materials                                               |   | (X)    |   | X      |   |   |   | 6      |   | 1      |   | 6      |   | PM     |   |
| Subsequent      ICF revisions (amendments)                                            |   | (X)    |   | X      |   |   |   | 6      |   | 1      |   | 6      |   | PM     |   |
| IND      Safety alert reporting to sites                                              |   | (X)    |   | X      |   |   |   | 0.75   |   | 13     |   | 9.75   |   | PM     |   |
| Annual      re-approval documentation                                                 |   | (X)    |   | X      |   |   |   | 1      |   | 20     |   | 20     |   | PM     |   |
| Study/site      closure documentation                                                 |   | (X)    |   | X      |   |   |   | 2      |   | 20     |   | 40     |   | PM     |   |
| IRB      payment facilitation                                                         |   | (X)    |   | X      |   |   |   | 0.5    |   | 20     |   | 10     |   | PM     |   |
| IRB      payment                                                                      |   | (X)    |   | X      |   |   |   | 0.5    |   | 20     |   | 10     |   | PM     |   |
| CRA                                                                                   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Training      – protocol, project & therapy area                            |   |   |   | X      |   |   |   |   |   |   |   |   |   |   |   |
| Initial      CRA training                                                             |   |   |   |   |   |   |   | 8      |   | 4      |   | 32     |   | CRA    |   |
| Periodic      CRA training (i.e. amendments, forms, SOPs, other new      information) |   |   |   |   |   |   |   | 8      |   | 4      |   | 32     |   | CRA    |   |
| Team      Teleconference                                                              |   |   |   | X      |   |   |   | 0.8    |   | 296    |   | 222    |   | CRA    |   |
| Site      Selection Visits                                                            |   |   |   | N/A    |   |   |   |   |   |   |   |   |   |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO      Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|-----------------------|-------------------------|
| Version      Date: | 16DEC2008           | Work      Order #:    | WO4                     |

| Contact      sites and confirm date for visit                       |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|---------------------------------------------------------------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|
| Send      confirmation letter                                       |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Interview      PI and site staff regarding experience               |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      project requirements and expectations                   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Tour      facility and assess site                                  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Prepare      report and make recommendation of site suitability     |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Prep                                                                |   |   |   |   |   |   |   | 1      |   | 1      |   | 1      |   | CRA    |   |
| Travel                                                              |   |   |   |   |   |   |   | 8      |   | 1      |   | 8      |   | CRA    |   |
| On-Site                                                             |   |   |   |   |   |   |   | 3      |   | 1      |   | 3      |   | CRA    |   |
| Report      Writing and Follow-up                                   |   |   |   |   |   |   |   | 5      |   | 1      |   | 5      |   | CRA    |   |
| Total                                                               |   |   |   |   |   |   |   | 17     |   | 0      |   | 0      |   | CAA    |   |
| Site      Initiation Visit                                          |   |   |   | X      |   |   |   |   |   |   |   |   |   |   |   |
| Contact      sites and confirm date for visit and provide an agenda |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Send      confirmation letter                                       |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Complete      Monitors’ Sign-in Log                           |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      regulatory documentation                                |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      Study protocol and CRF including:                       |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Inclusion/exclusion      criteria                                   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Efficacy      parameters and measurement                            |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Study      schedule                                                 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Complete/evaluable      patient definitions                         |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Study      medication procedures                                    |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Lab      requirements                                               |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| CRF      completion instructions                                    |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      adverse event reporting, including:                     |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Definition      of AEs and SAEs                                     |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Requirements      for documentation collection                      |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Proper      procedures for reporting SAEs to Sponsor and REB        |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Follow-up      requirements                                         |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      Investigational Brochure                                |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      communication channels                                  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      requirements for source documentation                   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| IRB/site      responsibilities                                      |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      monitoring schedule                                     |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      study site documentation                                |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Train      study coordinators                                       |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Review      PI contract and payment schedule                        |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Prepare      study initiation visit report                          |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Send site      SIV report and ackg. Form                                                |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
|----------------------------------------------------------------------------------------------|--------------|--------|--------------|--------|--------|--------|--------------|--------|--------------|--------|--------------|--------|--------------|--------|--------|
| Prep                                                                                         |         |   |         |   |   |   |         | 1      |         | 1      |         | 1      |         | CRA    |   |
| Travel                                                                                       |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | CRA    |   |
| On-Site                                                                                      |         |   |         |   |   |   |         | 5      |         | 1      |         | 5      |         | CRA    |   |
| Report      Writing and Follow-up                                                            |         |   |         |   |   |   |         | 5      |         | 1      |         | 5      |         | CRA    |   |
| Sub-Total/site                                                                               |         |   |         |   |   |   |         |   |         |   |         | 19     |         | CRA    |   |
| Total                                                                                        |         |   |         |   |   |   |         | 19     |         | 20     |         | 380    |         | CRA    |   |
| Interim      Monitoring                                                                      |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Send      confirmation letter                                                                |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Complete      Monitors’ Sign-in Log                                                    |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Verify      proper Informed Consent procedures                                               |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Monitor      in accordance with protocol/ICH/GCP                                             |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| 100%      source document verification vs. CRF                                               |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Assess      patient eligibility (protocol inclusion/exclusion/randomization      criteria)   |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Provide      site with written query records to be retained with each    CRF                 |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Review      study-related regulatory documents                                               |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Review      monitoring & discrepancy report queries                                      |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Source      verify data clarification/correction forms                                       |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Review      of laboratory data                                                               |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Review      and verify SAEs (100% SDV)                                                       |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Verify      study drug inventory and storage                                                 |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Verify      proper accountability and destruction of IP and study supplies per      protocol |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Maintain      protocol violation list                                                        |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Monitoring      of other variables as specified                                              |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Prepare      monitoring visit reports following each monitoring visit                        |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Provide      monitoring follow-up reports to sites following each visit                      |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Regulator      contacts with sites & TC reports                                          |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Ongoing      training of site personnel                                                      |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| CRF      and query management                                                                |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Prep                                                                                         |         |   |         |   |   |   |         | 2      |         | 1      |         | 2      |         | CRA    |   |
| Travel                                                                                       |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | CRA    |   |
| On-Site                                                                                      |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | CRA    |   |
| Report      Writing and Follow-up                                                            |         |   |         |   |   |   |         | 5      |         | 1      |         | 5      |         | CRA    |   |
| Sub-Total/site                                                                               |         |   |         |   |   |   |         |   |         |   |         | 23     |         | CRA    |   |
| Total                                                                                        |         |   |         |   |   |   |         | 23     |         | 258    |         | 5925   |         | CRA    |   |
| Un-Blinded      CRA                                                                          |    | N/A    |    |   |   |   |    |   |    |   |    |   |    |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Close      Out Visit                                                                       |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
|--------------------------------------------------------------------------------------------|--------------|--------|--------------|--------|--------|--------|--------------|--------|--------------|--------|--------------|--------|--------------|--------|--------|
| COV      within 6 weeks post data base lock                                                |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Contact      potential sites, confirm data for visit                                       |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Send      confirmation letter                                                              |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Complete      Monitors’ Sign-in Log                                                  |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Ensure      site regulatory documentation is complete and accessible future      audits    |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Ensure      that the investigator is aware of his/her responsibilities                     |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Financial      Disclosure documentation                                                    |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Ensure      that any remaining clinical trial material is removed from the study      site |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Prepare      COV report following visit                                                    |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Provide      follow-up report to sites                                                     |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Follow-up      with sites to resolve open issues                                           |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Prep                                                                                       |         |   |         |   |   |   |         | 2      |         | 1      |         | 2      |         | CRA    |   |
| Travel                                                                                     |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | CRA    |   |
| On-Site                                                                                    |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | CRA    |   |
| Report      Writing and Follow-up                                                          |         |   |         |   |   |   |         | 5      |         | 1      |         | 5      |         | CRA    |   |
| Sub-Total/site                                                                             |         |   |         |   |   |   |         |   |         |   |         | 23     |         | CRA    |   |
| Total                                                                                      |         |   |         |   |   |   |         | 23     |         | 20     |         | 460    |         | CRA    |   |
| Site      Management/Interaction (1hr/site/week)                                           |         |   |         |   |   |   |         | 10     |         | 134    |         | 1340   |         | CRA    |   |
| Lead      CRA                                                                              |         | N/A    |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Overall      Project Management                                                            |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Training      – protocol, project & therapy area                                 |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Initial      PM training                                                                   |         |   |         |   |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| Periodic      PM training                                                                  |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| In-house      study management                                                             |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Selection      – CDN site                                                            |         | X      |         |   |   |   |         |   |         |   |         |   |         | PM     |   |
| Feasibility      from admin                                                                |         | X      |         |   |   |   |         |   |         |   |         |   |         | PM     |   |
| Confidential      Disc. Agreement                                                          |         | X      |         |   |   |   |         |   |         |   |         |   |         | PM     |   |
| CDA      approval                                                                          |         | X      |         |   |   |   |         |   |         |   |         |   |         | PM     |   |
| CRTRA      template                                                                        |         | X      |         |   |   |   |         |   |         |   |         |   |         | PM     |   |
| CTRA      template approval                                                                |         | X      |         |   |   |   |         |   |         |   |         |   |         | PM     |   |
| CTRA      negotiation                                                                      |         | X      |         |   |   |   |         |   |         |   |         |   |         | PM     |   |
| CTRA      site sign off                                                                    |         | X      |         |   |   |   |         |   |         |   |         |   |         | PM     |   |
| Preparation      of initial project specific reg pkg                                       |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Review      received reg docs:                                                             |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| site      – QUI                                                                      |         |   |         | X      |   |   |         | 0.25   |         | 20     |         | 5      |         | PM     |   |
| REBA                                                                                       |         |   |         | X      |   |   |         | 0.25   |         | 20     |         | 5      |         | PM     |   |
| CTSI                                                                                       |    |   |    | X      |   |   |    | 0.25   |    | 20     |    | 5      |    | PM     |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Consent      to Use Personal Data                                                   |         |   |         | N/A    |   |   |         |   |         |   |         |   |         |   |   |
|-------------------------------------------------------------------------------------|--------------|--------|--------------|--------|--------|--------|--------------|--------|--------------|--------|--------------|--------|--------------|--------|--------|
| Protocol      signature page                                                        |         |   |         | X      |   |   |         | 0.25   |         | 20     |         | 5      |         | PM     |   |
| Financial      Disclosure                                                           |         |   |         | X      |   |   |         | 0.25   |         | 20     |         | 5      |         | PM     |   |
| CV                                                                                  |         |   |         | X      |   |   |         | 0.25   |         | 20     |         | 5      |         | PM     |   |
| MD      qualification                                                               |         |   |         | X      |   |   |         | 0.25   |         | 20     |         | 5      |         | PM     |   |
| Internal      project team meetings – biweekly                                |         |   |         | X      |   |   |         | 1      |         | 74     |         | 74     |         | PM     |   |
| Site      level management                                                          |         |   |         | X      |   |   |         | 8      |         | 20     |         | 160    |         | PM     |   |
| Weekly      Regular status reports for client                                       |         |   |         | X      |   |   |         | 1      |         | 148    |         | 148    |         | PM     |   |
| Liaise      weekly with sponsor                                                     |         |   |         | X      |   |   |         | 1      |         | 148    |         | 148    |         | PM     |   |
| TMF      set-up and maintenance oversight                                           |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Site      budge set-up                                                              |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Payment      calculation (quarterly)                                                |         |   |         | X      |   |   |         | 1      |         | 206    |         | 206    |         | PM     |   |
| Payment      tracking                                                               |         |   |         | X      |   |   |         | 0.5    |         | 205    |         | 103    |         | PM     |   |
| Payment      issuance                                                               |         |   |         | X      |   |   |         | 0.25   |         | 206    |         | 51.5   |         | PM     |   |
| SOPs      assignment documentation                                                  |         |   |         | X      |   |   |         | 3      |         | 1      |         | 3      |         | PM     |   |
| Responsibility      assignment                                                      |         |   |         | X      |   |   |         | 1      |         | 1      |         | 1      |         | PM     |   |
| Preparation      of Project Plan (1 review)                                         |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Preparation      of Monitoring Plan (1 review)                                      |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Preparation      of Visit Booklet (1 review)                                        |         |   |         | X      |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| Development      of Pharmacy Manual (1 review)                                      |         |   |         | X      |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| Development      of SAE Plan                                                        |         |   |         | X      |   |   |         | 16     |         | 1      |         | 16     |         | PM     |   |
| Development      of Recruitment Plan                                                |         |   |         | X      |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| Review      of Monitoring Trip Reports                                              |         |   |         | X      |   |   |         | 1      |         | 258    |         | 258    |         | PM     |   |
| Prep.      Of Study specific forms                                                  |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Prep.      Study specific tracking tools                                            |         |   |         | X      |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| QoL,      questionnaires and/or patient diaries, patient (alert)    cards)          |         |   |         | X      |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| Drug      Accountability Form                                                       |         |   |         | X      |   |   |         | 4      |         | 1      |         | 4      |         | PM     |   |
| Individual      Subject Drug logs                                                   |         |   |         | X      |   |   |         | 4      |         | 1      |         | 4      |         | PM     |   |
| Drug      Return & Reconciliation Form                                          |         |   |         | X      |   |   |         | 4      |         | 1      |         | 4      |         | PM     |   |
| Clinical      Re-supplies Form                                                      |         |   |         | X      |   |   |         | 1      |         | 1      |         | 1      |         | PM     |   |
| Drug      Receipt Form                                                              |         | X      |         | X      |   |   |         | 1      |         | 1      |         | 1      |         | PM     |   |
| Release      of IP (RIP) Form                                                       |         | X      |         | (X)    |   |   |         | 1      |         | 1      |         | 1      |         | PM     |   |
| Destruction      of IP (DIP) Form                                                   |         |   |         | (X)    |   |   |         | 1      |         | 1      |         | 1      |         | PM     |   |
| Study      specific tracking tools                                                  |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Investigational      Product (IP) and other Clinical Study Supplies                 |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Labeling,      coding and packing of IP (including provision of sample      labels) |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Comparator      Procurement                                                         |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Preparation      of written instructions for handling and storage of IP             |    | X      |    |   |   |   |    |   |    |   |    |   |    |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Request      for import/export approvals for IP                      |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
|----------------------------------------------------------------------|--------------|--------|--------------|--------|--------|--------|--------------|--------|--------------|--------|--------------|--------|--------------|--------|--------|
| Preparation      of custom clearance(s)                              |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Storage      of IP oversight                                         |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Request      for authorization to release IP oversight               |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Authorization      to distribute drug                                |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Packaging/labelling      of Clinical Supplies Oversight              |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Distribution      of Clinical Study Supplies to sites                |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Tracking      of IP                                                  |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Tracking      of Clinical Study Supplies                             |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Organization      of destruction of unused Clinical Study Supplies   |         |   |         | X      |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| Study      Completion/Study Termination                              |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Notification      to national/local authorities of study termination |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Final      recon of TMF                                              |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Archiving      of Sponsor’s TMF                                |         |   |         | X      |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| PM      – Pre-Study/Specific Task Sub-Total                    |         |   |         |   |   |   |         |   |         |   |         | 1383.5 |         | PM     |   |
| Local      Management Sub-Total (est. hours/week x # wks)            |         |   |         |   |   |   |         | 10     |         | 134    |         | 1340   |         | PM     |   |
| Ex-house      Project Management                                     |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Co-Initiation/Monitoring/COV                                         |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Prep                                                                 |         |   |         |   |   |   |         | 1      |         | 1      |         | 1      |         | PM     |   |
| Travel                                                               |         |   |         |   |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| On-Site      (average)                                               |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Admin                                                                |         |   |         |   |   |   |         | 3      |         | 1      |         | 3      |         | PM     |   |
| Sub-Total/site                                                       |         |   |         |   |   |   |         |   |         |   |         | 24     |         | PM     |   |
| Total                                                                |         |   |         |   |   |   |         | 24     |         | 4      |         | 96     |         | PM     |   |
| Ad      hoc meetings                                                 |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Prep                                                                 |         |   |         |   |   |   |         | 1      |         | 1      |         | 1      |         | PM     |   |
| Travel                                                               |         |   |         |   |   |   |         | 12     |         | 1      |         | 12     |         | PM     |   |
| On-Site      (average)                                               |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | PM     |   |
| Admin                                                                |         |   |         |   |   |   |         | 3      |         | 1      |         | 3      |         | PM     |   |
| Sub-Total/Mtg                                                        |         |   |         |   |   |   |         |   |         |   |         | 24     |         | PM     |   |
| Total                                                                |         |   |         |   |   |   |         | 245    |         | 12     |         | 288    |         | PM     |   |
| Administration      – COA & Document Management            |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Start      Up Documentation Activities                               |         | (X)    |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Assemble      site reg. packages                                     |         |   |         |   |   |   |         | 1.25   |         | 20     |         | 25     |         | COA    |   |
| Courier      packages to sites                                       |         |   |         |   |   |   |         | 0.25   |         | 20     |         | 5      |         | COA    |   |
| Initial      review of Regulatory Documents                          |    |   |    |   |   |   |    | 1.5    |    | 20     |    | 30     |    | COA    |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Receive,      log, scan & file initial reg docs        |         |   |         |   |   |   |         | 1.5    |         | 20     |         | 30     |         | COA    |   |
|------------------------------------------------------------|--------------|--------|--------------|--------|--------|--------|--------------|--------|--------------|--------|--------------|--------|--------------|--------|--------|
| Follow-up      on reg doc errors & omissions           |         |   |         |   |   |   |         | 0.5    |         | 15     |         | 7.5    |         | COA    |   |
| Courier      – second round                          |         |   |         |   |   |   |         | 0.25   |         | 15     |         | 3.75   |         | COA    |   |
| Second      review of regulatory documents                 |         |   |         |   |   |   |         |   |         | 15     |         | 7.5    |         | COA    |   |
| Receive,      log, scan & file 2nd      round reg docs |         |   |         |   |   |   |         |   |         | 15     |         | 15     |         | COA    |   |
| Identify      Table of Contents for ISF/IHF/GSF            |         |   |         |   |   |   |         |   |         | 1      |         | 1      |         | COA    |   |
| Assemple      PI Site Files (ISF) for TMF                  |         |   |         |   |   |   |         |   |         | 20     |         | 30     |         | COA    |   |
| Courier      site ISF to PI                                |         |   |         |   |   |   |         |   |         | 20     |         | 5      |         | COA    |   |
| Assemble      In-House site File (IHF) (GSF) for TMF       |         |   |         |   |   |   |         |   |         | 20     |         | 20     |         | COA    |   |
| Crease      eTMF folders                                   |         |   |         |   |   |   |         |   |         | 1      |         | 8      |         | COA    |   |
| CRF      related admin                                     |         |   |         | N/A    |   |   |         |   |         |   |         |   |         |   |   |
| CDA      – send to sites; review; send to Client     |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| CTRA      – send to sites; review; send to Client    |         | X      |         |   |   |   |         |   |         |   |         |   |         |   |   |
| General      Admin                                         |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Post      tracking tools to web for client                 |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Assist      with IRB/reg. authority submissions            |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Ongoing      regulatory doc. tracking /scanning            |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Contact      sites for enrolment updates                   |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| High      level site support                               |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Assist      with query resolution                          |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| TC      minutes                                            |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| COA      General Admin Total                               |         |   |         |   |   |   |         | 15     |         | 148    |         | 2220   |         | COA    |   |
| General      –TMF (Document Management)              |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Document      receipt & sorting                        |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Document      review for completeness                      |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Management      of deficiencies                            |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Scanning      & hard copy filing                       |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| e-naming      & e-filing                               |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Maintenance      of document tracking tool                 |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Ongoing      review of TMF for completeness                |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Ongoing      document retrieval and re-filing              |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Fax,      email or courier docs to CRAs/Sponsor            |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Return      of Sponsor’s TMF                         |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Document      Management General TMF Total (hrs/week)      |         |   |         |   |   |   |         | 10     |         | 148    |         | 1480   |         | DOC    |   |
| Allphase      Center of Excellence (ACE) Training          |         | N/A    |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Medical      Writing                                       |         | N/A    |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Quality      Assurance                                     |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Familiarization      with client SOPs (if applicable)      |    |   |    | X      |   |   |    |   |    |   |    |   |    |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Familiarization      with protocol                                   |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
|----------------------------------------------------------------------|--------------|--------|--------------|--------|--------|--------|--------------|--------|--------------|--------|--------------|--------|--------------|--------|--------|
| Inspection      of site regulatory files                             |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Review      and assessment of site SOPs                              |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Random      sampling of source & CRF data                        |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Discussion      with site personnel re: processes and findings       |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Inspection      of client TMF regulatory files                       |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Review      of vendor facilities, SOPs, processes                    |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Discussion      with vendor personnel re: processes and findings     |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Preparation      of audit report                                     |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Follow-up      resolutions                                           |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Vendor      Audits                                                   |         | N/A    |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Site      Audits                                                     |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Prep                                                                 |         |   |         |   |   |   |         | 8      |         |   |         |   |         |   |   |
| Travel                                                               |         |   |         |   |   |   |         | 12     |         |   |         |   |         |   |   |
| On-Site                                                              |         |   |         |   |   |   |         | 16     |         |   |         |   |         |   |   |
| Admin/Report      Writing                                            |         |   |         |   |   |   |         | 12     |         |   |         |   |         |   |   |
| Sub-Total                                                            |         |   |         |   |   |   |         | 48     |         | 3      |         | 144    |         | QA     |   |
| TMF      Audit                                                       |         |   |         | N/A    |   |   |         |   |         |   |         |   |         |   |   |
| Prep                                                                 |         |   |         |   |   |   |         | 8      |         |   |         |   |         |   |   |
| Travel                                                               |         |   |         |   |   |   |         | 8      |         |   |         |   |         |   |   |
| On-Site                                                              |         |   |         |   |   |   |         | 32     |         |   |         |   |         |   |   |
| Admin/Report      Writing                                            |         |   |         |   |   |   |         | 12     |         |   |         |   |         |   |   |
| Sub-Total                                                            |         |   |         |   |   |   |         | 60     |         | 0      |         | 0      |         | QA     |   |
| Safety                                                               |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Overall      Medical Oversight                                       |         | (X)    |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| 24/7      coverage                                                   |         |   |         |   |   |   |         | 0.25   |         | 134    |         | 33.5   |         | MM     |   |
| Consultation      with sites                                         |         |   |         |   |   |   |         | 0.25   |         | 128    |         | 32     |         | MM     |   |
| Consultation      with Client                                        |         |   |         |   |   |   |         | 1      |         | 11     |         | 11     |         | MM     |   |
| Protocol      deviation decision making and management (as required) |         |   |         |   |   |   |         | 0.75   |         | 13     |         | 9.75   |         | MM     |   |
| SAE      Trend Analysis                                              |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | MM     |   |
| Lab      alert review                                                |         |   |         |   |   |   |         | 1      |         | 6      |         | 6      |         | MM     |   |
| Protocol      deviation processing and tracking                      |         |   |         |   |   |   |         | 0.75   |         | 128    |         | 96     |         | PM     |   |
| AE/SAE      Database Setup                                           |         | N/A    |         |   |   |   |         |   |         |   |         |   |         |   |   |
| SAE      Collection, Processing & Reporting                      |         | (X)    |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Review      of SAE Plan                                              |         |   |         |   |   |   |         | 4      |         | 1      |         | 4      |         | MM     |   |
| SAE      report receipt, processing & follow-up                  |         |   |         |   |   |   |         | 3      |         | 64     |         | 192    |         | DS     |   |
| CIOMs      generation                                                |         |   |         |   |   |   |         | 3      |         | 13     |         | 39     |         | DS     |   |
| Submit      Alert Reports to Reg. Agencies/IRB/Sponsor               |    |   |    |   |   |   |    | 2      |    | 13     |    | 39     |    | DS     |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Submit      SAE Reports to Sites                                                                                                                                                                    |         |   |         |   |   |   |         | 1.5    |         | 13     |         | 26     |         | DS     |   |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------------|--------|--------------|--------|--------|--------|--------------|--------|--------------|--------|--------------|--------|--------------|--------|--------|
| Annual      safety reporting                                                                                                                                                                        |         |   |         |   |   |   |         | 16     |         | 3      |         | 19.5   |         | PM     |   |
| Teleconferences      with Sponsor                                                                                                                                                                   |         |   |         |   |   |   |         | 2      |         | 11     |         | 48     |         | MM     |   |
| SAE      Medical Evaluation                                                                                                                                                                         |         | (X)    |         | X      |   |   |         |   |         |   |         | 22     |         | MM     |   |
| SAE      review of report & supporting info                                                                                                                                                     |         |   |         |   |   |   |         | 0.75   |         | 64     |         | 48     |         | MM     |   |
| SAE      Narrative                                                                                                                                                                                  |         |   |         |   |   |   |         | 0.75   |         | 64     |         | 48     |         | MM     |   |
| Data      Safety Monitoring Board                                                                                                                                                                   |         |   |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Formation      and Management                                                                                                                                                                       |         | (X)    |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Provide      3 suitable board members (2MD; 1 Biostat) & facilitate (3) meetings by      teleconference                                                                                         |         |   |         |   |   |   |         | 24     |         | 1      |         | 24     |         | PM     |   |
| Organize      DSMB meetings                                                                                                                                                                         |         |   |         |   |   |   |         | 12     |         | 3      |         | 36     |         | PM     |   |
| Interact      with sponsor regarding conclusions                                                                                                                                                    |         |   |         |   |   |   |         | 8      |         | 3      |         | 24     |         | PM     |   |
| Implement      next steps                                                                                                                                                                           |         |   |         |   |   |   |         | 8      |         | 3      |         | 24     |         | PM     |   |
| Charter,      SOPs, Meeting #1                                                                                                                                                                      |         | (X)    |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Creation      of draft & final SOP, Charter, Open & Closed Report format;      provide support/advice for creating DSMB and defining its duties &      responsibilities for the project |         |   |         |   |   |   |         | 24     |         | 1      |         | 24     |         | PM     |   |
| Meeting      #1 (PM): discussion of protocol, procedures, role & functioning of      DSMB                                                                                                       |         |   |         |   |   |   |         | 6      |         | 1      |         | 6      |         | PM     |   |
| Meeting      #1 (COA): Attendance & Minutes                                                                                                                                                     |         |   |         |   |   |   |         | 8      |         | 1      |         | 8      |         | COA    |   |
| Meeting      #1 (MM): discussion of protocol, procedures, role & functioning of      DSMB                                                                                                       |         |   |         |   |   |   |         | 6      |         | 1      |         | 6      |         | MM     |   |
| Meeting      #1 (BIO): discussion of protocol, procedures, role & functioning of      DSMB                                                                                                      |         | X      |         |   |   |   |         |   |         |   |         |   |         | BIO    |   |
| Administration                                                                                                                                                                                      |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| Distribute      meeting materials                                                                                                                                                                   |         |   |         |   |   |   |         | 2      |         | 3      |         | 6      |         | COA    |   |
| MM:      Review of protocol & related changes, SAP, minutes, reports,      etc.                                                                                                                 |         |   |         |   |   |   |         | 16     |         | 1      |         | 16     |         | MM     |   |
| BIO:      Review of protocol & related changes, SAP, minutes, reports,      etc.                                                                                                                |         | X      |         |   |   |   |         |   |         |   |         |   |         | BIO    |   |
| Board      Member Participation & Evaluation                                                                                                                                                    |         |   |         | X      |   |   |         |   |         |   |         |   |         |   |   |
| MM x      2: Meetings #2 (closed) & #3 (open) by teleconference                                                                                                                                 |         |   |         |   |   |   |         | 12     |         | 2      |         | 24     |         | MM     |   |
| BIO:      Meetings #2 (closed) & #3(open) by teleconference                                                                                                                                     |         | X      |         |   |   |   |         |   |         |   |         |   |         | BIO    |   |
| Preparation      of Open & Closed minutes (non-CRO personnel)                                                                                                                                   |         |   |         |   |   |   |         | 8      |         | 2      |         | 16     |         | COA    |   |
| BIO:      preparation of Open & Closed reports                                                                                                                                                  |         | X      |         |   |   |   |         |   |         |   |         |   |         | BIO    |   |
| DM:      preparation of database extract for Open & Closed    reports                                                                                                                           |         | X      |         |   |   |   |         |   |         |   |         |   |         | DM     |   |
| Data      Management                                                                                                                                                                                |         | N/A    |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Biostatistical      Services                                                                                                                                                                        |         | N/A    |         |   |   |   |         |   |         |   |         |   |         |   |   |
| Data      Management – Licenses and Fees                                                                                                                                                      |    | N/A    |    |   |   |   |    |   |    |   |    |   |    |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| YM      BioSciences Inc. |    | 5045      Orbitor Drive, Building 11, Suite 400Mississauga,      Ontario, Canada L4W 4Y4Telephone:      905.629.9761Facsimile:      905.629.4959Website:      www.ymbiosciences.com |
|--------------------------|--------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| Project      Start-up/Initiation:                                        |   | Cost                            |      |
|--------------------------------------------------------------------------|--------|---------------------------------|-----------|
|                                                                     |   |                            |      |
| CRF      Design                                                          |   | Included      under DM estimate |      |
|                                                                     |   |                            |      |
| Grant      Payment Administration                                        |   |                            | 36,050.00 |   |
|                                                                     |   |                            |      |   |
| Critical      Document Collection/TMF Set-up/QA/Site ID &Feasibility |   |                            | 21,381.25 |   |
|                                                                     |   |                            |      |   |
| Monitoring      Plan/CRA manual                                          |   |                            | 2,000.00  |   |
|                                                                     |   |                            |      |   |
| Site      Binders/Study Procedures (reference) Manual                    |   |                            | 1,200.00  |   |
|                                                                     |   |                            |      |   |
| Sub-Total:                                                               |   | $                               | 60,631.25 |   |

| Investigator      Meeting:                       |   | Cost   |      |
|--------------------------------------------------|--------|--------|-----------|
|                                             |   |   |      |
| Investigator      meeting set-up/Coordination    |   |   | 12.575.00 |   |
|                                             |   |   |      |   |
| Investigator      meeting preparation/Attendance |   |   | 18,710.00 |   |
|                                             |   |   |      |   |
| Sub-Total:                                       |   | $      | 31,285.00 |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Clinical      Site Monitoring and Site Management: |   | Cost                         |       |
|----------------------------------------------------|--------|------------------------------|------------|
|                                               |   |                         |       |
| Project      team training/Familiarization         |   |                         | 10,380.00  |   |
|                                               |   |                         |       |   |
| Site      Selection Visits                         |   |                         | 0.00       |   |
|                                               |   |                         |       |   |
| Site      Initiation Visits                        |   |                         | 34,200.00  |   |
|                                               |   |                         |       |   |
| Interim      Site Monitoring Visits                |   |                         | 533,232.00 |   |
|                                               |   |                         |       |   |
| Interim      Site Monitoring Visits (follow-up)    |   | included      in above       |       |
|                                               |   |                         |       |   |
| Site      Close-out Visits                         |   |                         | 41,400.00  |   |
|                                               |   |                         |       |   |
| Site      Interaction (Telephone Contact)          |   |                         | 120,600.00 |   |
|                                               |   |                         |       |   |
| Query      Management                              |   | included      in site visits |       |
|                                               |   |                         |       |   |
| Essential      Document/Site file Maintenance      |   | included      in site visits |       |
|                                               |   |                         |       |   |
| Trial      Master File reconciliations             |   | included      in site visits |       |
|                                               |   |                         |       |   |
| Clinical      Monitoring Oversight (PM)            |   |                         | 25,800.00  |   |
|                                               |   |                         |       |   |
| Project      Kick-off meeting                      |   |                         | 7,160.00   |   |
|                                               |   |                         |       |   |
| Mid-Study      project team meeting                |   |                         | 7,160.00   |   |
|                                               |   |                         |       |   |
| Teleconferences      with YM BioSciences           |   |                         | 34,780.00  |   |
|                                               |   |                         |       |   |
| Internal      Team Meetings                        |   |                         | 7,400.00   |   |
|                                               |   |                         |       |   |
| Sub-Total:                                         |   | $                            | 822,112.00 |   |

| Medical      Management:                            |   | Cost                            |      |
|-----------------------------------------------------|--------|---------------------------------|-----------|
|                                                |   |                            |      |
| Project      Team training/Familiarization          |   |                            | 1,400.00  |   |
|                                                |   |                            |      |   |
| Medical      Monitoring (includes DSMB involvement) |   |                            | 60,787.50 |   |
|                                                |   |                            |      |   |
| Review      of AE Coding                            |   | included      under DM estimate |      |
|                                                |   |                            |      |   |
| Annual      Safety Reporting                        |   |                            | 16,800.00 |   |
|                                                |   |                            |      |   |
| Project      Kick-off meeting                       |   |                            | 2,450.00  |   |
|                                                |   |                            |      |   |
| Teleconferences      with YM BioSciences            |   |                            | 7,700.00  |   |
|                                                |   |                            |      |   |
| Internal      Team meetings                         |   |                            | 2,450.00  |   |
|                                                |   |                            |      |   |
| Sub-Total:                                          |   | $                               | 91,588.00 |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Pharmacovigilance:                         |   | Cost                            |      |
|--------------------------------------------|--------|---------------------------------|-----------|
|                                       |   |                            |      |
| Project      Team Training/Familiarization |   | included      in Med Mgmt above |      |
|                                       |   |                            |      |
| Create      SAE Management Plan            |   |                            | 3,000.00  |   |
|                                       |   |                            |      |   |
| SAE      Processing                        |   |                            | 40,550.00 |   |
|                                       |   |                            |      |   |
| Safety      Narratives Writing             |   |                            | 20,700.00 |   |
|                                       |   |                            |      |   |
| SAE      Reconciliation                    |   | included      in Med Mgmt above |      |
|                                       |   |                            |      |   |
| Sub-Total:                                 |   | $                               | 64,250.00 |   |

| Quality      Assurance Site Audits: |   | Cost   |      |
|-------------------------------------|--------|--------|-----------|
|                                |   |   |      |
| QA      Site Audits                 |   |   | 14,400.00 |   |
|                                |   |   |      |   |
| Sub-Total:                          |   | $      | 14,400.00 |   |

| Project      Management and Administrative Support: |   | Cost   |       |
|-----------------------------------------------------|--------|--------|------------|
|                                                |   |   |       |
| Project      Management and Support                 |   |   | 414,725.00 |   |
|                                                |   |   |       |   |
| Regulatory      Document/Site File Maintenance      |   |   | 111,000.00 |   |
|                                                |   |   |       |   |
| Sub-Total:                                          |   | $      | 525,735.00 |   |

| Total      Labour:                        |   | $      | 1,609,991.25 |   |
|-------------------------------------------|--------|--------|--------------|--------|
|                                      |   |   |         |   |
| Pass-Through      Expenses:               |   | $      | 352,341.00   |   |
|                                      |   |   |         |   |
| ACTUAL      TOTAL ESTIMATED PROJECT COST: |   | $      | 1,962,332.25 |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Service                                                                |   | Resp.  |   | Approx.# hours |   |   | HourlyRate |   |   | TOTALS |   |
|------------------------------------------------------------------------|--------|--------|--------|---------------------|--------|--------|------------|--------|--------|--------|--------|
| Project      Management (PM)                                           |   |
| Pre-Study      Activities                                              |   | PM     |   |                | 1,426  |   |       | $      | 100    |   |   | $ | 142,500 |   |
| Local      Investigator’s Meeting                                |   | PM     |   |                | 97     |   |       | $      | 100    |   |   | $ | 9,700 |   |
| Ethics                                                                 |   | PM     |   |                | 173.75 |   |       | $      | 100    |   |   | $ | 17,375 |   |
| Co-Initiation/IMV/COV                                                  |   | PM     |   |                | 96     |   |       | $      | 100    |   |   | $ | 9,600 |   |
| Ad      hoc meetings                                                   |   | PM     |   |                | 288    |   |       | $      | 100    |   |   | $ | 28,800 |   |
| Safety      - SAE                                                      |   | PM     |   |                | 116    |   |       | $      | 100    |   |   | $ | 11,550 |   |
| Safety      – DSMB                                               |   | PM     |   |                | 138    |   |       | $      | 100    |   |   | $ | 13,800 |   |
| Local      Management                                                  |   | PM     |   |                | 1,340  |   |       | $      | 100    |   |   | $ | 134,000 |   |
| Sub-Total                                                              |   | PM     |   |                | 3,674  |   |       | $      | 100    |   |   | $ | 367,375 |   |
| Scientific      Affairs                                                |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| Pre-Study      Activities                                              |   | DIR    |   |                | 4      |   |       | $      | 120    |   |   | $ | 480 |   |
| Sub-Total                                                              |   | DIR    |   |                | 4      |   |       | $      | 120    |   |   | $ | 480 |   |
| Clinical      Monitoring (CRA)                                         |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| Pre-Study      Activities                                              |   | CRA    |   |                | 144    |   |       | $      | 90     |   |   | $ | 12,960 |   |
| Local      Investigator’s Meeting                                |   | CRA    |   |                | 104    |   |       | $      | 90     |   |   | $ | 9,360 |   |
| Teleconferences                                                        |   | CRA    |   |                | 222    |   |       | $      | 90     |   |   | $ | 19,980 |   |
| Training                                                               |   | CRA    |   |                | 64     |   |       | $      | 90     |   |   | $ | 5,760 |   |
| Site      Selection Visits                                             |   | CRA    |   |                | 0      |   |       | $      | 90     |   |   | $ | 0 |   |
| Initiation      Visits                                                 |   | CRA    |   |                | 380    |   |       | $      | 90     |   |   | $ | 34,200 |   |
| Interim      Monitoring                                                |   | CRA    |   |                | 5925   |   |       | $      | 90     |   |   | $ | 533,232 |   |
| Close-Out      Visit                                                   |   | CRA    |   |                | 460    |   |       | $      | 90     |   |   | $ | 41,400 |   |
| Site      Management/Interaction                                       |   | CRA    |   |                | 1340   |   |       | $      | 90     |   |   | $ | 120,600 |   |
| Sub-Total                                                              |   | CRA    |   |                | 8639   |   |       | $      | 90     |   |   | $ | 777,492 |   |
| Clinical      Operations Associate (COA)                               |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| Pre-Study      & Specific Tasks                                    |   | COA    |   |                | 208    |   |       | $      | 75     |   |   | $ | 15,581 |   |
| Local      Investigator’s Meeting                                |   | COA    |   |                | 107    |   |       | $      | 75     |   |   | $ | 8,025 |   |
| DSMB                                                                   |   | COA    |   |                | 30     |   |       | $      | 75     |   |   | $ | 2,250 |   |
| General                                                                |   | COA    |   |                | 2220   |   |       | $      | 75     |   |   | $ | 166,500 |   |
| Sub-Total                                                              |   | COA    |   |                | 2565   |   |       | $      | 75     |   |   | $ | 192,356 |   |
| Document      Management Associate (DOC)                               |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| General      TMF Maintenance                                           |   | DOC    |   |                | 1480   |   |       | $      | 75     |   |   | $ | 111,000 |   |
| Sub-Total                                                              |   | DOC    |   |                | 1480   |   |       | $      | 75     |   |   | $ | 111,000 |   |
| Quality      Assurance (QA)                                            |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| Site      Audits                                                       |   | QA     |   |                | 144    |   |       | $      | 100    |   |   | $ | 14,400 |   |
| TMF      Audit                                                         |   | QA     |   |                | 0      |   |       |   | #100   |   |   | $ | 0 |   |
| Sub-Total                                                              |   | QA     |   |                | 144    |   |       | $      | 100    |   |   | $ | 14,400 |   |
| Drug      Safety - Management                                          |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| Drug      Safety                                                       |   | DS     |   |                | 257    |   |       | $      | 100    |   |   | $ | 25,700 |   |
| Sub-Total                                                              |   | DS     |   |                | 257    |   |       | $      | 100    |   |   | $ | 25,700 |   |
| Medical      Monitoring                                                |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| Pre-Study      Activities                                              |   | MM     |   |                | 18     |   |       | $      | 350    |   |   | $ | 6,300 |   |
| Local      Investigator’s Meeting                                |   | MM     |   |                | 12     |   |       | $      | 350    |   |   | $ | 4,200 |   |
| Medical      Monitoring                                                |   | MM     |   |                | 270    |   |       | $      | 350    |   |   | $ | 94,588 |   |
| DSMB                                                                   |   | MM     |   |                | 46     |   |       | $      | 350    |   |   | $ | 16,100 |   |
| Sub-Total                                                              |   | MM     |   |                | 346    |   |       | $      | 350    |   |   | $ | 121,188 |   |
| Estimated      Project Operational – Sub-Total                   |   |   | $      | 1,609,991           |   |
|                                                                   |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| Estimated      Project Pass-Through Costs – Sub-Total            |   |   | $      | 352,341             |   |
|                                                                   |   |   |   |                |   |   |       |   |   |   |   |   |   |   |
| Estimated      Project - Total                                         |   |   | $      | 1,962,332           |   |
| Estimated      Project – Total/patient (Labour only)             |   |   | $      | 12,578              |   |
| Estimated      Project – Total/patient (Labour and pass-through) |   |   | $      | 15,331              |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

|                                                                                                                                   |   |                |   |   |           |     |   | TOTALS      (CDN) |   |   |            |   |
|----------------------------------------------------------------------------------------------------------------------------------------|--------|---------------------|--------|--------|----------------|----------|--------|-------------------|--------|--------|-----------------|--------|
| Pass-Through      Expenses                                                                                                             |   |                |   |   | Unit      Cost |     |   | #      Units      |   |   | Total      Cost |   |
| Travel      Expenses (1 Day Trip)                                                                                                      |   |                | 75     | %      |           |     | 200.00 |              |   |   | 276             |   |   | $ | 55,200 |   |
| Travel      Expenses (2 Day Trip)                                                                                                      |   |                | 25     | %      |           |     | 800.00 |              |   |   | 92              |   |   | $ | 73,600 |   |
| Meal      Expenses - day trip                                                                                                          |   | per      day        |   |   |           | 30.00    |   |              |   | 276    |            |   | $ | 8,280 |   |
| Monitor      Overnight Expenses (ie. Hotel)                                                                                            |   | per      trip       |   |   |           | 200.00   |   |              |   | 184    |            |   | $ | 36,800 |   |
| Meal      Expenses - overnight                                                                                                         |   | per      trip       |   |   |           | 60.00    |   |              |   | 184    |            |   | $ | 11,040 |   |
| Quality      Assurance / Site Audit                                                                                                    |   | per      trip       |   |   |           | 1,500.00 |   |              |   | 3      |            |   | $ | 4,500 |   |
| Allphase      & Client Meeting Expenses                                                                                            |   | per      person     |   |   |           | 600.00   |   |              |   | 12     |            |   | $ | 7,200 |   |
| Miscellaneous      Expenses (consumables* and communication costs) = $120 pp/month (active      period)/CRA                            |   | per      month      |   |   |           | 120.00   |   |              |   | 125    |            |   | $ | 15,000 |   |
| Miscellaneous      Expenses (consumables* and communication costs) = $120 pp/month for the      entire study duration: 1PM & 1 COA |   | per      month      |   |   |           | 120.00   |   |              |   | 69     |            |   | $ | 8,280 |   |
| CRF      Printing                                                                                                                      |   | per      CRF        |   |   |           | 50.00    |   |              |   | 0      |            |   | $ | 0 |   |
| Diaries      in French and English                                                                                                     |   |                |   |   |           | TBD      |   |              |   |   |            |   |   |   |   |
| Translation                                                                                                                            |   |                |   |   |           | TBD      |   |              |   |   |            |   |   |   |   |
| Teleconferences                                                                                                                        |   | per      conf.      |   |   |           | 25.00    |   |              |   | 74.00  |            |   | $ | 1,850 |   |
| Mailing                                                                                                                                |   | per      letter     |   |   |           | 2.00     |   |              |   | 408.00 |            |   | $ | 816 |   |
| Courier                                                                                                                                |   | per      package    |   |   |           | 25.00    |   |              |   | 148.00 |            |   | $ | 3,700 |   |
| Finance      Couriers (expenses)                                                                                                       |   | per      package    |   |   |           | 25.00    |   |              |   | 37.00  |            |   | $ | 925 |   |
| Newsletters                                                                                                                            |   | per      newsletter |   |   |           | 2.00     |   |              |   | 0      |            |   | $ | 0 |   |
| TMF      Regulatory Binders                                                                                                            |   | per      site       |   |   |           | 50.00    |   |              |   | 20     |            |   | $ | 1,000 |   |
| Regulatory      Binders                                                                                                                |   | per      site       |   |   |           | 50.00    |   |              |   | 20     |            |   | $ | 1,000 |   |
| Study      Reference Binders                                                                                                           |   | per      site       |   |   |           | 50.00    |   |              |   | 20     |            |   | $ | 1,000 |   |
| Investigator      Grants                                                                                                               |   | per      patient    |   |   | TBD            |     |   |              | 128    |   |            | $      | 0 |   |
| Ethics      Committee/IRB Fees                                                                                                         |   | per      site       |   |   | TBD            |     |   |              | 0      |   |            |   |   |   |
| Insurance                                                                                                                              |   | per      site       |   |   | TBD            |     |   |              | 0      |   |            |   |   |   |
| Advertising                                                                                                                            |   | per      site       |   |   | TBD            |     |   |              | 0      |   |            |   |   |   |
| Pharmacy      Set up fees                                                                                                              |   | per      site       |   |   | TBD            |     |   |              | 0      |   |            |   |   |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

|                                                                      |   |            |   |   |     |   | Sub-Total: |       |   | $      | 230,191 |    |
|---------------------------------------------------------------------------|--------|-----------------|--------|--------|----------|--------|------------|------------|--------|--------|---------|---------|
| Local      Investigator’s Meeting                                   |   |            |   |   |     |   |       |       |   |   |    |    |
| Investigator      Meeting Airfare - site staff (PI business, CRC economy) |   | per      site   |   |   | 1,950.00 |   |       |       | 40     |   |    | $       | 78,000 |   |
| Investigator      Meeting Airfare - Allphase staff (all economy)          |   | per      person |   |   | 900.00   |   |       |       | 3      |   |    | $       | 2,700 |   |
| Investigator      Meeting Hotel - site staff (3 nights)                   |   | per      person |   |   | 750.00   |   |       |       | 40     |   |    | $       | 30,000 |   |
| Investigator      Meeting Hotel - Allphase staff (3 nights)               |   | per      person |   |   | 750.00   |   |       |       | 3      |   |    | $       | 2,250 |   |
| Transportation      and meals                                             |   | per      person |   |   | 200.00   |   |       |       | 46     |   |    | $       | 9,200 |   |
|                                                                      |   |            |   |   |     |   |       | Sub-Total: |   |   | $       | 122,150 |   |
|                                                                      |   |            |   |   |     |   |       | Total      |   |   | $       | 352,341 |   |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| ·   | Monthly      labour invoices will be issued |
|--------------------|---------------------------------------------|

| ·   | Expense      invoices to be issued once original receipts have been collected from      personnel. |
|--------------------|----------------------------------------------------------------------------------------------------|

| ·   | Expenses      related to courier, teleconferencing, and communication & consumables      will be summarized on expense invoices. Original documentation will not be      provided but is available for review for an additional fee (labour      required to anonymize). |
|--------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| ·   | Applicable      taxes on labor will be indicated oninvoice. |
|--------------------|-------------------------------------------------------------|

| ·   | Payment      terms are 30 days from receipt ofinvoice. |
|--------------------|--------------------------------------------------------|

| ·   | 2%      per month financing fee may be applied to outstanding balance      owing. |
|--------------------|-----------------------------------------------------------------------------------|

| ·   | Sponsor      authorization will be obtained if budget exceeds 10% of      estimate. |
|--------------------|-------------------------------------------------------------------------------------|

| ·   | The      Client acknowledges that upon execution of the full Work Order, Allphase      will dedicate personnel to this Project, on a full time or part time basis      as appropriate. If after 90 days following the date of execution of this      Work Order (exclusive of the letter of Intent provisions) the project is      delayed for greater than 30 days for reasons beyond the control of      Allphase (e.g. regulatory hold), if Client wishes to retain the assigned      project team, Client agrees to pay Allphase its direct costs per assigned      employee. This value will be calculated based on the average number of      hours billed per individual over the preceding 3 months. This will be a      daily calculation starting on day 31 post written notification of the      effective date of the delay. If billable work continues during the delay      period and the value of this work is at least equal to Allphase direct      costs, then no additional fee will be levied. Alternately, Allphase may      re-assign personnel to other Projects, or Client and Allphase may      negotiate alternate arrangements to minimize the economic impact on both      Parties. |
|--------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Signature:                                         |    |                                              | Signature: |    |
|----------------------------------------------------|--------------|---------------------------------------------------|------------|--------------|
|                                               |         |                                              |
| Date:      December 24, 2008                       |         | Date:      January 5, 2009                        |
|                                               |         |                                              |
| Name/Title:      David Allan/Chairman & CEO    |         | Name/Title:      Jeff Smith/President             |
|                                               |         |                                              |
| I      have the authority to bind the corporation. |    | I      have the authority to bind thecorporation. |

----

----

| MSA#:              | YMB07-MSA-17MAY2007 | WO Version Code: | YMB08-WO4-15DEC2008-3.0 |
|--------------------|---------------------|----------------------------|-------------------------|
| Version Date: | 16DEC2008           | Work Order #:    | WO4                     |

| Agreed      and accepted                        |         | Agreed      and accepted                          |
|-------------------------------------------------|--------------|---------------------------------------------------|
|                                            |         |                                              |
| YM      BioSciences Inc.                        |         | ALLPHASE      Clinical Research Inc.              |
|                                            |         |                                              |
| Date:      December 24, 2008                    |         | Date:      January 5, 2009                        |
|                                            |         |                                              |
| Signature:                                      |    |                                              | Signature: |    |
|                                            |         |                                              |
| Name/Title:      David Allan/Chairman & CEO |         | Name/Title:      Jeff Smith/President             |
|                                            |    | I      have the authority to bind thecorporation. |

| Date: |    |
|-------|--------------|

| Signature: |    |
|------------|--------------|

| Name/Title: |    |
|-------------|--------------|

----

----