### B

- 1 Appendix B

RQ Calculations for Primary Exposure (Consumption of Bait) Scenarios

### B

- 2 Table B

- 1 Acute Oral RQs for Generic and Passerine Birds Based on Consumption of Bait.

Taxa Weight

(g) Food

intake

(g dry

wt/day) Rodent

icide

intake

(mg

a.i./kg

bwt/day) Un

adjusted

LD 50 (mg a.i./

kg

- bwt) 1 Adjusted LD 50 (mg a.i./kg

- bwt) 2 RQ

(unad

justed) 3,4 RQ

(adjusted for

weight) 4,5

Brodifacoum

— 0.005% a.i.

Passeriform

Birds 20 5.1 12.70

0.25 0.65 0.40 50.79* 19.61 * 31.56 *

100 19.9 9.97 0.44 0.33 39.90* 22.67 * 30.07 *

1000 141.2 7.06 0.25 0.25 28.24* 27.89 * 28.07 *

Generic

Birds 20 4.6 11.39 0.65 0.40 45.56* 17.59 * 28.31 *

100 13.0 6.49 0.44 0.33 25.98* 14.76 * 19.58 *

1000 58.2 2.91 0.25 0.25 11.63* 11.48 * 11.56 *

Difethialone

— 0.0025%

Passeriform

Birds 20 5.1 6.35

0.3 0.21 21.16 * 29.80 *

100 19.9 4.99 0.27 16.62 * 18.39 *

1000 141.2 3.53 0.38 11.77 * 9.22 *

Generic

Birds 20 4.6 5.69 0.21 18.98 * 26.73 *

100 13.0 3.25 0.27 10.82 * 11.97 *

1000 58.2 1.45 0.38 4.85 * 3.80 *

Warfarin

— 0.025% a.i.

Passeriform

Birds 20 5.1 63.49

540 272.6 0.12 0.23

100 19.9 49.87 347.0 0.10 0.14

1000 141.2 35.30 490.2 0.07 0.07

Generic

Birds 20 4.6 56.95 272.6 0.11 0.21

100 13.0 32.47 347.0 0.06 0.09

1000 58.2 14.54 490.2 0.03 0.03

Warfarin

— 0.054% a.i.

Passeriform

Birds 20 5.1 137.13

540 272.6 0.26 0.50 *

100 19.9 107.72 347.0 0.21 0.31

1000 141.2 76.26 490.2 0.15 0.16

Generic

Birds 20 4.6 123.00 272.6 0.23 0.45

100 13.0 70.14 347.0 0.34 0.20

1000 58.2 31.40 490.2 0.06 0.06

Chlorophacinone

-- 0.005% a.i.

Passeriform

Birds 20 5.1 12.70

258 182.4 8943.6 0.05 0.07 <0.01

100 19.9 9.97 232.2 762.2 0.04 0.04 0.01

1000 141.2 7.06 327.9 22.5 0.03 0.02 0.32

Generic

Birds 20 4.6 11.39 182.4 8943.6 0.04 0.06 <0.01

100 13.0 6.49 232.2 762.2 0.03 0.03 0.01

1000 58.2 2.91 327.9 22.5 0.01 0.01 0.13

Diphacinone

— 0.005% a.i.

Passeriform

Birds 20 5.1 12.70

1630 1163 0.01 0.01

100 19.9 9.97 1480 0.01 0.01

1000 141.2 7.06 2091 < 0.01 <0.01

Generic

Birds 20 4.6 11.39 1163 0.01 0.01

100 13.0 6.49 1480 < 0.01 <0.01

1000 58.2 2.91 2091 < 0.01 <0.01

Bromethalin

— 0.01%

Passeriform 20 5.1 25.39 4.6 3.27 5.52* 7.76 *

### B

- 3 Table B

- 1 Acute Oral RQs for Generic and Passerine Birds Based on Consumption of Bait.

Taxa Weight

(g) Food

intake

(g dry

wt/day) Rodent

icide

intake

(mg

a.i./kg

bwt/day) Un

adjusted

LD 50 (mg a.i./

kg

- bwt) 1 Adjusted LD 50 (mg a.i./kg

- bwt) 2 RQ

(unad

justed) 3,4 RQ

(adjusted for

weight) 4,5

Birds 100 19.9 19.95 4.16 4.34* 4.79 *

1000 141.2 14.12 5.88 3.07* 2.40 *

Generic

Birds 20 4.6 22.78 3.27 4.95* 6.96 *

100 13.0 12.99 4.16 2.82* 3.12 *

1000 58.2 5.82 5.88 1.26* 0.99 *

1 LD 50 from most sensitive mallard duck or northern bobwhite quail acute oral study.

2 Split columns show LD 50 s adjusted using different scaling factors. For brodifacoum, the left and right columns give

the adjusted LD 50 using brodifacoum specific scaling factor from Mineau et al. (1996) and (2001), respectively. For

chlorophacinone, the left and right columns gives the adjusted LD 50 using the EFED default scal ing factor from

Mineau et al. (1996) and the chlorophacinone specific scaling factor from Mineau et al. (2001), respectively. For

other chemicals, the single column gives the adjusted LD 50 using the EFED default scaling factor from Mineau et al.

(1996).

3 RQ calculated as daily rodenticide intake / LD 50

. 4 * RQ exceeds Acute Risk LOC.

5 Split columns show RQs calculated from the respective adjusted LD 50 , see footnote #2.

### B

- 4 Table B

- 2 Generic and Passerine Birds : Time to consume an LD 50 

### - dose of Bait and grams of bait needed to reach the

LD 50 

### - dose.

Taxa Weight

(g) Unadjusted

LD 50 (mg a.i./ kg

bwt) 1 Adjusted LD 50 (mg a.i./kg

- bwt) 2 D ays to

consume an

unadjusted

LD 50 - dose of

bait D ays to consume an

adjusted LD 50 - dose of

bait 3 Grams of

bait to

consume an

unadjusted

LD 50 - dose Grams of bait to

consume an

adjusted LD 50 -

dose 4

Brodifacoum

— 0.005%

Passeriform

Birds 20

0.25 0.65 0.40 <1 <1 < 1 0.1 0.3 0.3

100 0.44 0.33 <1 <1 <1 0.5 0.9 0.9

1000 0.25 0.25 <1 <1 <1 5 5 5

Generic

Birds 20 0.65 0.40 <1 <1 <1 0.1 0.3 0.2

100 0.44 0.33 <1 <1 <1 0.5 0.9 0.7

1000 0.25 0.25 <1 <1 <1 5 5 5

Difethialone

— 0.0025%

Passeriform

Birds 20

0.3 0 0.21 <1 <1 0.2 0.2

100 0.27 <1 <1 1.2 1.1

1000 0.38 <1 <1 12 15

Generic

Birds 20 0.21 <1 <1 0.2 0.2

100 0.27 <1 <1 1.2 1.1

1000 0.38 <1 <1 12 15

Warfarin

— 0.025% a.i.

Passeriform

Birds 20

5 25 272.6 8

- 9 4

- 5 46 25

100 347.0 11

- 12 7

- 8 239 160

1000 490.2 16

- 17 14

- 15 2400 2100

Generic

Birds 20 272.6 9

- 10 4

- 5 46 23

100 347.0 18

- 19 11

- 12 247 156

1000 490.2 46

- 47 41

- 42 2733 2442

Warfarin

— 0.054% a.i.

Passeriform

Birds 20

5 25 272.6 3

- 4 1

- 2 20 10

100 347.0 4

- 5 3

- 4 80 80

1000 490.2 7

- 8 6

- 7 140 990

Generic

Birds 20 272.6 4

- 5 2

- 3 23 14

100 347.0 7

- 8 5

- 6 104 78

1000 490.2 18

- 19 16

- 17 1105 989

Chlorophacinone

-- 0.005% a.i.

Passeriform 20 258 182.4 8876 25

- 26 16

- 17 >365 132 86 >1800

### B

- 5 Table B

- 2 Generic and Passerine Birds : Time to consume an LD 50 

### - dose of Bait and grams of bait needed to reach the

LD 50 

### - dose.

Taxa Weight

(g) Unadjusted

LD 50 (mg a.i./ kg

bwt) 1 Adjusted LD 50 (mg a.i./kg

- bwt) 2 D ays to

consume an

unadjusted

LD 50 - dose of

bait D ays to consume an

adjusted LD 50 - dose of

bait 3 Grams of

bait to

consume an

unadjusted

LD 50 - dose Grams of bait to

consume an

adjusted LD 50 -

dose 4

Birds 100 232.2 757 35

- 36 30

- 31 >365 718 620 >7300

1000 327.9 22.3 62

- 63 117

- 118 3

- 4 8897 17000 565

Generic

Birds 20 182.4 894 4 29

- 30 18

- 19 >365 136 87 >1663

100 232.2 757 75

- 76 60

- 61 >365 987 792 >4741

1000 327.9 22.3 >365 >365 8

- 9 >21200 >21200 523

Diphacinone

— 0.005% a.i.

Passeriform

Birds 20

1630 1167 >365 >365 >1800 >1800

100 1485 >365 >365 >7300 >7300

1000 2098 >365 >365 >52000 >52000

Generic

Birds 20 1167 >365 >365 >1660 >1660

100 1485 >365 >365 >4740 >4740

1000 2098 >365 >365 >21200 >21200

Bromethalin

— 0.01%

Passeriform

Birds 20

4.6 3.27 <1 <1 0.9 0.7

100 4.16 <1 <1 4.6 4.2

1000 5.88 <1 <1 46 59

Generic

Birds 20 3.27 <1 <1 0.9 0.7

100 4.16 <1 <1 4.6 4.2

1000 5.88 <1 <1 46 59

1 LD 50 from most sensitive mallard duck or northern bobwhite quail acute oral study.

2 Split columns show LD 50 s adjusted using different scaling factors. For brodifacoum, the left and right columns give the adjusted LD 50 using

brodifacoum specific scaling factor from Mineau et al. (1996) and (2001), respectively. For chlorophacinone, the left and right columns gives the

adjusted LD 50 using the EFED default scaling factor from Mineau et al. (1996) and the chlorophacinone specific scaling factor from Mineau e t al.

(2001), respectively. For other chemicals, the single column gives the adjusted LD 50 using the EFED default scaling factor from Mineau et al. (1996).

3 Split columns show days to consume sufficient bait to reach the LD 50 calculated from the respective adjus ted LD 50 , see footnote #2

. 4 Split columns show bait (g) to consume to reach the LD 50 calculated from the respective adjusted LD 50 , see footnote #2

.

### B

- 6 Table B

- 3 Acute Oral RQs for Passerine and Generic Birds Based on Consumption of

Bait accumulated over a six day feeding exposure.

Taxa Weight

(g) Rodenticide

six

- day

accumulati

on (mg

a.i./kg

- bwt) LD 50 (mg

a.i./kg

- bwt) 1 Adjusted LD 50 (mg a.i./kg

- bwt) 2 RQ based

on

unadjusted

LD 50 3,4 RQ (adjusted for

weight) 4,5

Brodifacoum

— 0.005% a.i.

Passeriform

Birds 20 76

0.25 0.65 0.40 303* 117* 188*

100 60 0.44 0.33 238* 135* 179*

1000 42 0.25 0.25 169* 166* 167*

Generic

Birds 20 68 0.65 0.40 272* 105* 169*

100 39 0.44 0.33 155* 88* 117*

1000 17 0.25 0.25 69* 69* 69*

Difethialone

— 0.0025%

Passeriform

Birds 20 36

0.3 0.21 119* 168*

100 28 0.27 94* 104*

1000 20 0.38 66* 52*

Generic

Birds 20 32 0.21 107* 151*

100 18 0.27 61* 68*

1000 8 0.38 27* 21*

Warfarin

— 0.025% a.i.

Passeriform

Birds 20 371

540 272.6 0.71* 1.36*

100 292 347.0 0.56* 0.84*

1000 206 490.2 0.39 0.42

Generic

Birds 20 333 272.6 0.63* 1.22*

100 190 347.0 0.36 0.55*

1000 85 490.2 0.16 0.17

Warfarin

— 0.054% a.i.

Passeriform

Birds 20 802

540 272.6 1.53* 2.94*

100 630 347.0 1.20* 1.81*

1000 446 490.2 0.85* 0.91*

Generic

Birds 20 719 272.6 1.37* 2.64*

100 410 347.0 0.78* 1.18*

1000 184 490.2 0.45 0.37

Chlorophacinone

-- 0.005% a.i.

Passeriform

Birds 20 73

50 182.4 8943.6 0.28 0.40 0.01

100 57 232.2 762.2 0.22 0.25 0.08

1000 40 327.9 22.5 0.16 0.12 1.81*

Generic

Birds 20 65 182.4 8943.6 0.25 0.36 0.01

100 37 232.2 762.2 0.14 0.16 0.05

1000 17 327.9 22.5 0.06 0.05 0.74*

Diphacinone

— 0.005% a.i.

Passeriform

Birds 20 56

1630 1163 0.03 0.05

100 44 1480 0.03 0.03

1000 31 2091 0.02 0.01

Generic

Birds 20 50 1163 0.03 0.04

100 29 1480 0.02 0.02

1000 13 2091 0.01 0.01

Bromethalin

— 0.01%

Passeriform

Birds 20 112 4.6 3.27 NA 6 NA

100 88 4.16 NA NA

### B

- 7 Table B

- 3 Acute Oral RQs for Passerine and Generic Birds Based on Consumption of

Bait accumulated over a six day feeding exposure.

Taxa Weight

(g) Rodenticide

six

- day

accumulati

on (mg

a.i./kg

- bwt) LD 50 (mg

a.i./kg

- bwt) 1 Adjusted LD 50 (mg a.i./kg

- bwt) 2 RQ based

on

unadjusted

LD 50 3,4 RQ (adjusted for

weight) 4,5

1000 62 5.88 NA NA

Generic

Birds 20 101 3.27 NA NA

100 57 4.16 NA NA

1000 26 5.88 NA NA

1 LD 50 from most sensitive mallard duck or northern bobwhite quail acute oral study.

2 Split columns show LD 50 s adjusted using different scaling factors. For brodifacoum, the left and right columns

give the adjusted LD 50 using brodifacoum specific scaling factor from Mineau et al. (1996) and (2001),

respectively. For chlorophacinone, the left and right columns gives the adjusted LD 50 using the EFED default

scaling factor from Mineau et al. (1996) and the chlorophacinone specific scaling factor from Mineau et al.

(2001), respectively. For other chemicals, the single column gives the adjusted LD 50 using the EFED default

scaling factor from Mineau et al. (1996).

3 RQ calculated as 60

- day accumulated body bur den / LD 50

. 4 * RQ exceeds Acute Risk LOC.

5 Split columns show RQs calculated from the respective adjusted LD 50 , see footnote #2.

6 NA

- not applicable. Animals consuming bromethalin are not expected to continue feeding on bromethalin bait

for six days.

### B

- 8 Table B

- 4 Acute Oral RQs for Generic and Rodent Mammals Based on Consumption of

Bait.

Taxa Weight

(g) Food

intake

(g dry

wt/day) Rodenticide

intake

(mg a.i./kg

bwt/day) LD 50 (mg

a.i./kg

bwt) 1 Adjusted

LD 50 (mg

a.i./kg

- bwt) 2 RQ (un

adjusted) 3 ,4 RQ

(adjusted for

weight) 3,4

Brodifacoum

— 0.005% a.i.

Rodent

Mammals 15 2.9 9.53

0.48 0.96 19.86* 9.93*

35 4.6 6.59 0.78 13.73* 8.48*

1000 30.6 1.53 0.34 3.18* 4.55*

Generic

Mammals 15 2.2 7.26 0.96 15.12* 7.56*

35 4.4 6.24 0.78 13.00* 8.03*

1000 68.7 3.44 0.34 7.16* 10.23*

Difethialone

— 0.0025%

Rodent

Mammals 15 2.9 4.77

0.56 1.11 8.51* 4.30*

35 4.6 3.29 0.90 5.88* 3.67*

1000 30.6 0.76 0.39 1.36* 1.97*

Generic

Mammals 15 2.2 3.63 1.11 6.48* 3.27*

35 4.4 3.12 0.90 5.57* 3.48*

1000 68.7 1.72 0.39 3.07* 4.43*

Warfarin

— 0.025% a.i.

Rodent

Mammals 15 2.9 47.7

3 5.7 15.89* 8.36*

35 4.6 32.9 4.6 10.98* 7.14*

1000 30.6 7.6 2.0 2.55* 3.83*

Generic

Mammals 15 2.2 36.3 5.7 12.09* 6.36*

35 4.4 31.2 4.6 10.40* 6.76*

1000 68.7 17.2 2.0 5.73* 8.61*

Warfarin

– 0.054% a.i.

Rodent

Mammals 15 2.9 102.97

3 5.7 34.32* 18.05*

35 4.6 71.17 4.6 23.72* 15.42*

1000 30.6 16.50 2.0 5.50* 8.27*

Generic

Mammals 15 2.2 78.36 5.7 26.12* 13.74*

35 4.4 67.39 4.6 22.46* 14.60*

1000 68.7 37.11 2.0 12.37* 18.59*

Chlorophacinone

-- 0.005% a.i.

Rodent

Mammals 15 2.9 9.53

6.26 11.6 1.52* 0.82*

35 4.6 6.59 9.4 1.05* 0.70*

1000 30.6 1.53 4.1 0.24 0.38

Generic

Mammals 15 2.2 7.26 11.6 1.16* 0.63*

35 4.4 6.24 9.4 1.00* 0.67*

1000 68.7 3.44 4.1 0.55* 0.85*

Diphacinone

— 0.005% a.i.

Rodent

Mammals 15 2.9 9.53

2.46 4.8 4.13* 1.97*

35 4.6 6.59 3.9 2.83* 1.68*

1000 30.6 1.53 1.7 0.66* 0.90*

Generic

Mammals 15 2.2 7.26 4.8 3.14* 1.50*

35 4.4 6.24 3.9 2.70* 1.59*

1000 68.7 3.44 1.7 1.49* 2.03*

Bromethalin

— 0.01%

Rodent

Mammals 15 2.9 19.07

2.2 3.7 8.7* 5.1*

35 4.6 13.18 3.0 6.0* 4.4*

1000 30.6 3.06 1.3 1.4* 2.4*

### B

- 9 Table B

- 4 Acute Oral RQs for Generic and Rodent Mammals Based on Consumption of

Bait.

Taxa Weight

(g) Food

intake

(g dry

wt/day) Rodenticide

intake

(mg a.i./kg

bwt/day) LD 50 (mg

a.i./kg

bwt) 1 Adjusted

LD 50 (mg

a.i./kg

- bwt) 2 RQ (un

adjusted) 3 ,4 RQ

(adjusted for

weight) 3,4

Generic

Mammals 15 2.2 14.51 3.7 6.6* 3.9*

35 4.4 12.48 3.0 5.7* 4.1*

1000 68.7 6.87 1.3 3.1* 5.3*

1 LD 50 from most sensitive laboratory rat acute oral study.

2 LD 50 adjusted using the 

### “body weight 3⁄4 

### ” a djustment (USEPA 1995, 2011).

3 RQ calculated as daily rodenticide intake / LD 50

. 4 * RQ exceeds Acute Risk LOC.

### B

- 10 Table B

- 5

. Generic and Rodent Mammals : Time to consume an LD 50 

### - dose of Bait and grams of bait

needed to reach the LD 50 

### - dose.

Taxa Weight

(g) Unadjusted

LD 50 (mg a.i./ kg

bwt) 1 Adjusted

LD 50 (mg a.i./kg

bwt) 2 D ays to

consume an

unadjusted

LD 50 - dose of

bait D ays to

consume an

adjusted

LD 50 - dose of

bait Grams of

bait to

consume an

unadjusted

LD 50 - dose Grams of bait

to consume an

adjusted

LD 50 - dose

Brodifacoum

— 0.005% a.i.

Rodent

mammals 15

0.48 0.96 <1 <1 0.1 0.3

35 0.78 <1 <1 0.3 0.5

1000 0.34 <1 <1 9.6 6.7

Generic

mammals 15 0.96 <1 <1 0.1 0.3

35 0.78 <1 <1 0.3 0.5

1000 0.34 <1 <1 9.6 6.7

Difethialone

— 0.0025%

Rodent

mammals 15

0.56 1.11 <1 <1 0.3 0.7

35 0.90 <1 <1 0.8 1.3

1000 0.39 <1 <1 22 16

Generic

mammals 15 1.11 <1 <1 0.3 0.7

35 0.90 <1 <1 0.8 1.3

1000 0.39 <1 <1 22 16

Warfarin

— 0.025% a.i.

Rodent

mammals 15

3.0 5.7 <1 <1 0.2 0.3

35 4.6 <1 <1 0.4 0.7

1000 2.0 <1 <1 12 8.0

Generic

mammals 15 5.7 <1 <1 0.2 0.3

35 4.6 <1 <1 0.4 0.7

1000 2.0 <1 <1 12 8.0

Warfarin

— 0.054% a.i.

Rodent

mammals 15

3.0 5.7 <1 <1 0.1 0.2

35 4.6 <1 <1 0.2 0.3

1000 2.0 <1 <1 5.6 3.7

Generic

mammals 15 5.7 <1 <1 0.1 0.2

35 4.6 <1 <1 0.2 0.3

1000 2.0 <1 <1 5.6 3.7

### B

- 11 Table B

- 5

. Generic and Rodent Mammals : Time to consume an LD 50 

### - dose of Bait and grams of bait

needed to reach the LD 50 

### - dose.

Taxa Weight

(g) Unadjusted

LD 50 (mg a.i./ kg

bwt) 1 Adjusted

LD 50 (mg a.i./kg

bwt) 2 D ays to

consume an

unadjusted

LD 50 - dose of

bait D ays to

consume an

adjusted

LD 50 - dose of

bait Grams of

bait to

consume an

unadjusted

LD 50 - dose Grams of bait

to consume an

adjusted

LD 50 - dose

Chlorophacinone

-- 0.005% a.i.

Rodent

mammals 15

6.26 11.6 <1 1

- 2 1.9 6

35 9.4 <1 1

- 2 4.4 9

1000 4.1 1

- 2 1

- 2 61 61

Generic

mammals 15 11.6 <1 <1 1.9 3.5

35 9.4 <1 1

- 2 4.4 9

1000 4.1 2

- 3 1

- 2 206 137

Diphacinone

— 0.005% a.i.

Rodent

mammals 15

1.9 3.6 <1 <1 0.6 1.1

35 2.9 <1 <1 1.3 2.1

1000 1.3 <1 <1 38 25

Generic

mammals 15 3.6 <1 <1 0.6 1.1

35 2.9 <1 <1 1.3 2.1

1000 1.3 <1 <1 38 25

Bromethalin

— 0.01%

Rodent

mammals 15

2.2 3.7 <1 <1 0.3 0.6

35 3.0 <1 <1 0.8 1.1

1000 1.3 <1 <1 22 13

Generic

mammals 15 3.7 <1 <1 0.3 0.6

35 3.0 <1 <1 0.8 1.1

1000 1.3 <1 <1 22 13

1 LD 50 from most sensitive laboratory rat acute oral study.

2 LD 50 adjusted using the 

### “body weight 3⁄4 

### ” a djustment (USEPA 1995, 2011).

### B

- 12 Table B

- 6. Acute Oral RQs for Rodent and Generic Mammals Based on Consumption of

Bait accumulated over a six day feeding exposure.

Taxa Weight

(g) Rodenticide

six

- day

accumulation

(mg a.i./kg

bwt) LD 50 (mg

a.i./kg

- bwt) 1 Adjusted

LD 50 (mg

a.i./kg

bwt) 2 RQ based on

unadjusted

LD 50 3,4 RQ (adjusted

for weight) 3,4

Brodifacoum

— 0.005% a.i.

Rodent

Mammals 15 57

0.48 0.96 119* 59*

35 39 0.78 82* 51*

1000 9 0.34 19* 27*

Generic

Mammals 15 43 0.96 90* 45*

35 37 0.78 78* 48*

1000 20 0.34 43* 61*

Difethialone

— 0.0025%

Rodent

Mammals 15 27

0.56 1.11 48* 24*

35 19 0.90 33* 21*

1000 4 0.39 8* 11*

Generic

Mammals 15 20 1.11 37* 18*

35 18 0.90 31* 20*

1000 10 0.39 17* 25*

Warfarin

— 0.025% a.i.

Rodent

Mammals 15 279

3 5.7 93* 49*

35 193 4.6 64* 42*

1000 45 2.0 15* 22*

Generic

Mammals 15 212 5.7 71* 37*

35 182 4.6 61* 40*

1000 100 2.0 33* 50*

Warfarin

— 0.054% a.i.

Rodent

Mammals 15 602

3 5.7 201* 106*

35 416 4.6 139* 90*

1000 96 2.0 32* 48*

Generic

Mammals 15 458 5.7 153* 80*

35 394 4.6 131* 85*

1000 217 2.0 72* 109*

Chlorophacinone

-- 0.005% a.i.

Rodent

Mammals 15 54

6.26 11.6 8.70* 4.68*

35 38 9.4 6.02* 4.00*

1000 9 4.1 1.40* 2.14*

Generic

Mammals 15 41 11.6 6.62* 3.56*

35 36 9.4 5.70* 3.79*

1000 20 4.1 3.14* 4.82*

Diphacinone

— 0.005% a.i.

Rodent

Mammals 15 42

1.9 3.6 22.1* 11.6*

35 29 2.9 15.3* 9.9*

1000 7 1.3 3.5* 5.3*

Generic

Mammals 15 32 3.6 16.8* 8.8*

35 27 2.9 14.4* 9.3*

1000 15 1.3 8.0* 11.9*

Bromethalin

— 0.01%

Rodent

Mammals 15 84 2.2 3.7 NA 5 NA

35 58 3.0 NA NA

### B

- 13 Table B

- 6. Acute Oral RQs for Rodent and Generic Mammals Based on Consumption of

Bait accumulated over a six day feeding exposure.

Taxa Weight

(g) Rodenticide

six

- day

accumulation

(mg a.i./kg

bwt) LD 50 (mg

a.i./kg

- bwt) 1 Adjusted

LD 50 (mg

a.i./kg

bwt) 2 RQ based on

unadjusted

LD 50 3,4 RQ (adjusted

for weight) 3,4

1000 14 1.3 NA NA

Generic

Mammals 15 64 3.7 NA NA

35 55 3.0 NA NA

1000 30 1.3 NA NA

1 LD 50 from most sensitive laboratory rat acute oral study.

2 LD 50 adjusted using the 

### “body weight 3⁄4 

### ” a djustment (USEPA 1995, 2011).

3 RQ calculated as accumulated body burden / LD 50

. 4 * RQ exceeds Acute Risk LOC.

5 NA

- not applicable. Animals consuming bromethalin are not expected to continue feeding on bromethalin bait

for six days.