Exhibit 31.1



CERTIFICATION PURSUANT TO RULES 13a-14(a) CERTIFICATION IN ACCORDANCE WITH

SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002



I, George F. Horner III, President and Chief Executive Officer of Vicuron Pharmaceuticals Inc. (the Company), certify that:



1. I have reviewed this annual report on Form 10-K of the Company;



2. Based on my knowledge, this annual report does not contain any untrue statement of a
material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this annual report;



3. Based on my knowledge, the financial statements, and other financial information included
in this annual report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this annual report;



4. The registrants other certifying officer and I are responsible for establishing and
maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:



a) designed such disclosure controls and procedures, or caused
such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly
during the period in which this annual report is being prepared;



b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and
the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;



c) evaluated the effectiveness of the registrants disclosure controls and procedures and presented in this annual report our conclusions about the
effectiveness of the disclosure controls and procedures, as of the end of the period covered by this annual report based on such evaluation; and



d) disclosed in this annual report any change in the registrants internal control over financial reporting that occurred during the
registrants fourth fiscal quarter of 2004 that has materially affected, or is reasonable likely to materially affect, the registrants internal control over financial reporting; and



5. The registrants other certifying officer and I have disclosed, based on our most
recent evaluation of internal control over financial reporting, to the registrants auditors and the audit committee of registrants board of directors (or persons performing the equivalent functions):



a) all significant deficiencies and material weaknesses in the design or
operation of internal controls over financial reporting which are reasonably likely to adversely affect the registrants ability to record, process, summarize and report financial information; and



b) any fraud, whether or not material, that involves management or other
employees who have a significant role in the registrants internal control over financial reporting.



|                     |  |  |  |                                      
|-------------------- |  |  |  | -------------------------------------
|                     |  | 
|Date: March 14, 2005 |  |  |  | /s/ GEORGE F. HORNER III             
|                     |  |  |  | George F. Horner III                 
|                     |  |  |  | President and Chief Executive Officer