Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Pyraflufen-ethyl is classified as “likely to be carcinogenic to humans” by the oral route; 

therefore, a cancer dietary risk assessment is required. All exposure inputs were the same 

as the chronic dietary exposure assessment for the cancer assessment, except the EDWC. 

Chronic cancer dietary exposure from drinking water was determined based on a Tier 2 

(surface water) drinking water estimate provided by EFED. The EDWC estimate (30-

year average) value of 0.268 ppb for the combined residues of pyraflufen-ethyl and its 

metabolic products, E-1, E-2, and E-3 were incorporated directly into the dietary 

assessment to estimate carcinogenic risk from drinking water containing pyraflufen-ethyl. 

The cancer chronic dietary (food and water) exposure to pyraflufen-ethyl is 2x10-6. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD; i.e., no observed adverse effect level:

NOAEL) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk 

exceeds one in one million. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see 

SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for pyraflufen-ethyl was conducted by Leung 

Cheng (D378643, 02/08/2011).

II. Residue Information

Pyraflufen-ethyl [ethyl 2-chloro-5-(4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-

yl)-4-fluorophenoxyacetate], is a herbicide defoliant for which permanent tolerances have 

been established [40 CFR§180.585(a)] for the combined residues of pyraflufen-ethyl and 

its acid metabolite E-1 [2-chloro-5-(4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-

yl)-4-fluorophenoxyacetic acid], in almond hulls, corn, cotton, pome fruits, grapes, grass 

forage and hay, tree nuts, olives, pistachios, pomegranates, potatoes, soybeans, stone 

fruit, and wheat. Time limited tolerances of 0.02 ppm have been established for residues 

in milk and in the meat byproducts of cattle, goat, horse, and sheep (expiration date: 

10/15/12).
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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Residues of Concern: HED has concluded that the residues of concern in/on plants for 

tolerance enforcement and risk assessment include the parent and Metabolite E-1. The 

residues of concern in livestock commodities are the parent, Metabolite E-1, and 

Metabolite E-9 [2-chloro-5-(4-chloro-5-difluoromethoxy-1H-pyrazol-3-yl)-4-

fluorophenoxyacetic acid]. 

Plant commodities: Tolerances have been established for the combined residues of 

pyraflufen-ethyl and its acid metabolite E-1 at levels ranging from 0.01 ppm in/on 

various agricultural commodities to 1.5 ppm in/on cotton gin byproducts [40 

CFR§180.585(a)]. Average crop field trial data (1⁄2 of the combined LOQ for the parent 

and the metabolites) were used in the DEEM-FCID analyses for the following 

commodities: corn, cottonseed, potato, soybean, wheat, pome fruit, stone fruit, 

pomegranate, olive, grape, tree nuts, and pistachio. All other established and proposed 

commodities were analyzed using tolerance-level residues. 

Processed Commodities: Because the commodity-specific processing studies did not 

show concentration of pyraflufen-ethyl from processing, the chronic dietary exposure 

assessment did not incorporate processing factors for the following commodities: treated 

corn grain, soybean seeds, wheat grain, apples, and grapes. Sample chromatograms for 

treated apples and grapes also showed no difference from the untreated control samples. 

Processing data for apples and grapes may be extrapolated to stone fruits. Therefore, the 

concentration factors were assumed to be 1X for the processed commodities of pome 

fruit, grapes, and stone fruit. However, default processing factors were used for dry 

potatoes (6.5X), dried beef (1.92X), peanut butter (1.89X), and corn syrup (1.5X). An 

empirical processing factor of 0.6X was used for cotton seed oil. 

Livestock commodities: The livestock dietary burdens of pyraflufen-ethyl, based on 

maximum reasonably balanced diets (MRBD), were recently calculated by L. Cheng 

(D377361, 02/07/2011). The beef and dairy cattle dietary burdens were recalculated for 

the proposed uses of pyraflufen-ethyl on hops and peanuts. The calculated dietary 

burdens are 0.12 ppm for beef cattle (versus 0.25 ppm), 0.76 ppm for dairy cattle (versus 

1.8 ppm), 0.01 ppm for swine, and 0.01 ppm for poultry. The dietary burden calculations 

reflect established tolerances for corn, cotton, grass, soybean, and wheat commodities. 

Based on the calculated dietary burdens and a revision of the original cattle feeding study 

to include residue data for Metabolite E-9, HED recommended the establishment of 

tolerances for the combined residues of pyraflufen-ethyl, Metabolite E-1, and Metabolite 

E-9 in milk, and the fat, meat, and meat byproducts of cattle, goat, horse, and sheep at the 

combined LOQ of 0.001 ppm. HED concluded that the tolerances for poultry and hog 

commodities were not required because there is no reasonable expectation of finite 

residues in poultry or hog commodities. Horse meat byproducts are not included in the 

food consumption data from the USDA’s NHANES/WWEIA. Based on the relatively 

minor expected dietary contribution from peanut hay and meal to livestock diets (relative 

to more significant contributors, including corn, cotton, and grass), and the anticipated 

reduction in dietary burdens in general resulting from the change in values used in the 

calculations, HED does not believe that the addition of the proposed uses on peanut and 

hops will have an impact on the recommended tolerances for ruminant commodities, and 
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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will not affect the currents status of no tolerances needed for poultry and hog 

commodities. This conclusion is subject to revision upon submission of additional 

peanut bridging field trial study results. 

Table 1: Dietary Burdens of Pyraflufen-ethyl + E1 Residues to Livestock for Chronic & Cancer 

Assessment.

Feedstuff Type 1 % Dry 

Matter 2 % Diet 2 Residue Dietary Contribution (ppm) 3

Value used ppm

Beef Cattle (R 15%, CC 75%, and PC 10%)2

Grass, hay R 88 10 Median40.612 0.070

Cotton, gin byproducts R 90 5 Median40.712 0.040

Corn, field, grain/milled 

byproducts

CC 88 75 Tolerance 0.01 0.009

Soybean, meal PC 92 10 Tolerance 0.01 0.001

TOTAL BURDEN -- -- 100 0.12

Dairy Cattle (R 45%, CC 45%, and PC 10%)2

Grass, forage/silage R 25 45 Median40.416 0.748

Corn, field, grain/milled 

byproducts

CC 88 45 Tolerance 0.01 0.005

Cotton, undelinted seed PC 90 10 Tolerance 0.04 0.004

TOTAL BURDEN -- -- 100 0.76

1 R: Roughage; CC: Carbohydrate concentrate; PC: Protein concentrate.

2 OPPTS 860.1000 Table 1 Feedstuffs (June 2008).

3 Contribution = ([residue /% DM] X % diet) for beef and dairy cattle; contribution = (residue] X % diet) 

for poultry and swine. 

4 D339032 & D320103.

Previous Reviews: A proposed use on hops was incorporated into the previous chronic 

and cancer aggregate dietary exposure at 0.05 ppm (L. Cheng, D378643, 02/08/2011); 

however, the previous request for use on hops was not granted. In the interim, a new 

petition was submitted with a proposed tolerance of 0.01 ppm, and HED has updated 

DEEM-FCID to incorporate more recent dietary survey data; therefore, the proposed use 

on hops has been reevaluated here along with the proposed peanut use. 

Residue Data used for Chronic and Cancer Assessments:

The chronic and cancer dietary analyses were conducted for pyraflufen-ethyl 

incorporating exposure estimates from use on food and through drinking water. All 

available pyraflufen-ethyl field trials showed residues < LOQ; therefore, the chronic 

dietary exposure assessment incorporated 1⁄2 of the combined LOQ for the parent and the 

metabolites for the following commodities: corn, cottonseed, potato, soybean, wheat, 

pome fruit, stone fruit, pomegranate, olive, grape, tree nuts, and pistachio. All other 

established and proposed commodities were analyzed using tolerance-level residues. 

Because the commodity-specific processing studies did not show pyraflufen-ethyl 

concentration, the chronic dietary exposure assessment did not incorporate processing 

factors for the following commodities: corn grain (however, corn syrup data was not 
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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provided), soybean seeds, wheat grain, apples, and grapes. However, default processing 

factors were used for dry potatoes (6.5X), peanut butter (1.89X), dried beef (1.92), and 

corn syrup (1.5X). An empirical processing factor of 0.6X was used for cotton seed oil. 

The food residue data used in the chronic analyses are summarized below in Table 2.

Table 2: Residue Data used in the Chronic Dietary Analyses for Pyraflufen-ethyl.

Commodity Residue 

Level

Percent 

Crop 

Treated

Reference/Basis of Calculated Anticipated Residues or 

Feeding Level

Corn, field, grain*

0.005 100 DEEM default processing factor of 1.5x was used for corn 

syrup

Cottonseed 0.02 100 0.6x empirical processing factor for cottonseed oil

Grape* 0.005 100 Processing factors were set to 1

Hops 0.01 100 Proposed commodity

Olive* 0.005 100

Pome fruit* 0.005 100 Processing factors were set to 1

Pomegranate* 0.005 100

Potato 0.01 100 DEEM default processing factor of 6.5x was used for dried 

potatoes and potato flour

Peanuts 0.01 100 Proposed Commodity, DEEM default processing factor of 

1.89X used for peanut butter

Pistachio* 0.005 100

Soybean, seed* 0.005 100

Stone fruit* 0.005 100 Processing factors were set to 1

Tree nuts* 0.005 100

Wheat, grain* 0.005 100

Fat# 0.001 Extrapolation of feeding study results at the 9.8 ppm dose to a 

dietary burden of 0.76 ppm

Milk 0.001 Extrapolation of feeding study results at the 9.8 ppm dose to a 

dietary burden of 0.76 ppm

Meat#

0.001 100

Extrapolation of feeding study results at the 9.8 ppm dose to a 

dietary burden of 0.76 ppm; Dried beef processing factor 

1.92X

Meat byproducts^ 0.001 100 Extrapolation of feeding study results at the 9.8 ppm dose to a 

dietary burden of 0.76 ppm

*1⁄2 LOQ of combined residues of parent and metabolite E-1.

# of cattle, goat, horse, and sheep.

^ of cattle, goat, and sheep

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED 

(M. Barrett, D402766, 09/21/2012). The proposed use on peanuts did not change the 

EDWCs provided in the last drinking water assessment (M. Barrett, D377360, 

03/23/2011). The EDWCs were incorporated directly into this dietary exposure 

assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” Tier 2 EDWCs 

were calculated using the Pesticide Root Zone Model (PRZM-EXAMS, version 2.98.04). 

Water residues of 0.295 ppb and 0.268 ppb were incorporated directly DEEM-FCID into 

the categories “water, direct, all sources” and “water, indirect, all sources” for the chronic 
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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and cancer dietary exposure assessment, respectively. The EDWCs calculated using 

PRZM-EXAMS (surface water) and SCI-GROW (groundwater) for use in the human 

health risk assessment are presented in Table 3. The models and their descriptions are 

available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/. 

Table 3:Tier II EDWCs for Pyraflufen-ethyl, E-1, E-2, and E-3 (as Parent + E-1 and as total residues).

Exposure 

Duration

Nature of Residue / 

-- EDWC (as μg/L or ppb) --

Parent + E-1

*1 Total residues 

(Recommended)*2

Total Residues

(Experimental Estimate)*3

Peak 0.425*6

(FL Cucumber)

0.420

(ME Potato)

0640*6

(ME Potato)

0.589

(FL cucumber)

NC

Annual Average 0.127

(ID Potato)

0.295

(Assumes E-1 dominant; ID Potato)

0.284 

(Assumes E-3 dominant; ME Potato)

NC

30-year Average 0.117

(ID Potato)

0.268

(Assumes E-1 dominant; ID Potato)

0.222

(Assumes E-3 dominant; ME Potato)

0.198

(ID Potato)

Acute/Chronic 

(Ground Water)

0.0014 

(Potato)

0.0018*5

(Potato)

---

1 Residues of E-1 are expected to be the predominant component in these estimates, but the estimation procedure is inclusive of parent residues. 

2 For chronic exposure (annual and longer periods), model inputs designed to calculate chronic exposure to total residues most accurately (assumes E-3 

is likely the dominant long-term environmental residue). For acute exposure, estimates assumed all residues were as mobile as E-1, the dominate 

residue for short duration exposure.

3 Calculates residues from formulation and decline aspect using PRZM-EXAMS routines still in development and currently not approved for in risk 

assessments. This particular method assumed that E-1 is a more dominant environment residue than parent pyraflufen ethyl and that E-3 is more

dominant than E-3 as a long-term residue (therefore utilizing aggregate decline constants for parent + E-1 and aggregate formation and decline 

constants for E-2 + E-3). Note that, due to a programming error in PRZM the 1.0000 fractional conversion was entered as 0.6931 fractional which 

appears to entirely correct the error.

NC = Not calculated (separate post-processing of daily time series estimated values for parent and degradates would be calculated – this was not 

performed since these values from this experimental assessment method were not needed for reference in this review.)

4 Thirty years simulation, representative of lifetime exposure.

5 E-2 + E-3 estimated to be 0.00038 ppb.

6 For Peak exposure the estimates for each of the two highest scenarios is given (FL cucumber and ME potato) for Parent +E-1 residues and for total 

residues.

IV. DEEM-FCID Program and Consumption Information

Pyraflufen-ethyl acute and chronic dietary exposure assessments were conducted using 

the Dietary Exposure Evaluation Model software with the Food Commodity Intake 

Database DEEM-FCID, Version 3.16, which incorporates consumption data from 

USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. 

The data are based on the reported consumption of more than 20,000 individuals over 

two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to 
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population 

subgroups, but for acute exposure assessment are retained as individual consumption 

events. Based on analysis of the 2003-2008 WWEIA consumption data, which took into 

account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the chronic population adjusted dose (cPAD). This 

procedure is performed for each population subgroup.

V. Toxicological Information

The pyraflufen-ethyl risk assessment team confirmed endpoints that were previously 

selected for pyraflufen-ethyl in the most recent risk assessment (K. Rury, D377359, 

03/01/2011). The toxicological PODs selected for dietary exposure are summarized in 

Table 4. An appropriate endpoint attributable to a single oral dose was not available, and 

therefore an acute reference dose (RfD) was not established. The Food Quality 

Protection Act (FQPA) safety factor was reduced to 1X because pyraflufen-ethyl showed 

no evidence of increased susceptibility of the young. Pyraflufen-ethyl is classified as 

“likely to be carcinogenic to humans.” Therefore, a linear low-dose extrapolation (Q1

*

of 

3.32x10-2(mg/kg/day)

-1

) is used for quantification of human cancer risk from the oral 

(dietary) route of exposure. 

Table 4: Summary of Toxicological Doses and Endpoints for Pyraflufen-Ethyl for Use in Dietary Human Health 

Risk Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, 

Level of 

Concern for 

Risk 

Assessment

Study and Toxicological Effects

Acute Dietary 

(all populations) None None None An endpoint attributable to a single dose was not identified from the available data.
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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Table 4: Summary of Toxicological Doses and Endpoints for Pyraflufen-Ethyl for Use in Dietary Human Health 

Risk Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, 

Level of 

Concern for 

Risk 

Assessment

Study and Toxicological Effects

Chronic Dietary 

(all populations)

NOAEL = 

20

UFA=10X

UFH=10X

FQPA SF = 1X

Chronic

RfD = 0.20 

mg/kg/day

cPAD = 0.2 

mg/kg/day

Mouse Carcinogenicity

LOAEL = 98 mg/kg/day based on liver 

toxicity

Cancer (oral, 

dermal, 

inhalation)

Classification: “Likely to be Carcinogenic to Humans” by the oral route.

Q1* = 3.32 x 10-2(mg/kg/day)-1

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the 

beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no 

observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from 

animal to human (interspecies). UFH = potential variation in sensitivity among members of the human population (intraspecies). 

FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (c = chronic). RfD = reference dose. 

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure 

of the U.S. population and various population subgroups. The results reported in Table 5

are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, 

children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. Cancer 

risk is determined for the general U.S. population only.

Acute Dietary Exposure Results and Characterization

Pyraflufen-ethyl does not require an acute dietary exposure assessment since a 

toxicological endpoint attributable to a single dose was not identified from the available 

data. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The results of the chronic dietary exposure analysis are reported in the Table 5. The noncancer chronic dietary (food and drinking water) exposure analysis was a partially refined 

assessment which assumed that 100% of the crop was treated. Based on the assumptions 

described above (Section II), chronic dietary exposure estimates are not of concern to 

HED (i.e., <100% of the cPAD of 0.2 mg/kg/day). The combined chronic dietary 

exposure estimates are <1% for the general U.S. population and all the population 

subgroups, including children 1-2 years old, the most highly exposed population 

subgroup. 

Results of Cancer Dietary (Food and Drinking Water) Exposure Analysis
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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The results of the cancer dietary exposure analysis are reported in the Table 5. The 

estimated exposure of the general U.S. population to pyraflufen-ethyl is 0.000075 

mg/kg/day. Applying the Q1* of 3.32x10-2(mg/kg/day)

-1

to the exposure value results in 

a cancer estimate of 2x10-6. Therefore, estimated cancer risk is not of concern to HED.

Table 5: Summary of Dietary (Food and Drinking Water) Exposure and Risk for Pyraflufen-ethyl.

Population Subgroup

Chronic Dietary Cancer

Dietary 

Exposure

(mg/kg/day)

% cPAD1

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population 0.000053 <1.0% 0.000052 2x10-6

All Infants (< 1 year old) 0.00012 <1.0%

N/A N/A

Children 1-2 years old 0.00020 <1.0%

Children 3-5 years old 0.00014 <1.0%

Children 6-12 years old 0.000085 <1.0%

Youth 13-19 years old 0.000048 <1.0%

Adults 20-49 years old 0.000040 <1.0%

Adults 50+ years old 0.000035 <1.0%

Females 13-49 years old 0.000039 <1.0%

1. Highest exposure is in bold.

VII. Characterization of Inputs/Outputs

The chronic dietary exposure analysis is partially refined in that 1⁄2 the combined LOQs of 

the parent and metabolites are used for the residue values in the dietary assessment, rather 

than the established tolerances for corn, wheat, soybeans, cottonseed, potatoes, pome 

fruit, stone fruit, pomegranates, olives, grapes, tree nuts, and pistachios. The drinking 

water assessment was based on partially refined, Tier 2 estimates generated by PRZMEXAMS. However, the assessment assumed that 100% of the crops are treated with 

pyraflufen-ethyl, and the assessment incorporated some default processing factors (6.5X 

for dried potatoes, 1.89X for peanut butter, 1.5X for corn syrup, and 1.92 for dried beef), 

both conservative assumptions. Dietary estimates could be further refined through the 

use of percent crop treated data or monitoring data. 

VIII. Conclusions

Chronic dietary exposure analyses using DEEM-FCIDTM indicate that chronic dietary 

exposure to the combined residues of pyraflufen-ethyl and Metabolite E-1 from food and 

drinking water are not of concern to HED. The estimated chronic dietary exposure 

utilized <1.0% of the cPAD for the general U.S. population, and all population 

subgroups. The cancer risk estimate is 2x10-6and also not of concern to HED. 
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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IX. List of Attachments

• Chronic Food Residue Input file.

• Cancer Food Residue Input file.

• Chronic Results file.

• Cancer Results File.

cc: Kristin Rury, Myron Ottley, Amelia Acierto.
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Chronic Residue File:

Filename: C:\Documents and Settings\krury\My Documents\My Work Files\Pyraflufen Ethyl\Hops 

and Peanuts\Dietary Assessment\Hops and Peanuts\Hops and Peanuts CHRONIC revised dietary 

burden.R08

Chemical: Pyraflufen ethyl

RfD(Chronic): .2 mg/kg bw/day NOEL(Chronic): 20 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0332

Date created/last modified: 09-14-2012/15:25:39 Program ver. 3.16, 03-08-d

Comment: no acute tox endpoint; chronic water 0.295 ppb

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0103296000 1C Potato, chips 0.010000 1.000 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103297000 1C Potato, dry (granules/ flakes) 0.010000 6.500 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103297001 1C Potato, dry (granules/ flakes)-b 0.010000 6.500 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103298000 1C Potato, flour 0.010000 6.500 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103298001 1C Potato, flour-babyfood 0.010000 6.500 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 

0600347000 6 Soybean, seed 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0600349000 6 Soybean, soy milk 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0600349001 6 Soybean, soy milk-babyfood or in 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0600350000 6 Soybean, oil 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0600350001 6 Soybean, oil-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0603348000 6C Soybean, flour 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0603348001 6C Soybean, flour-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

1100007000 11 Apple, fruit with peel 0.005000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.005000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.005000 1.000 1.000 

1100009000 11 Apple, dried 0.005000 1.000 1.000 

1100009001 11 Apple, dried-babyfood 0.005000 1.000 1.000 

1100010000 11 Apple, juice 0.005000 1.000 1.000 

1100010001 11 Apple, juice-babyfood 0.005000 1.000 1.000 

1100011000 11 Apple, sauce 0.005000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.005000 1.000 1.000 

1100129000 11 Crabapple 0.005000 1.000 1.000 

1100210000 11 Loquat 0.005000 1.000 1.000 

1100266000 11 Pear 0.005000 1.000 1.000 

1100266001 11 Pear-babyfood 0.005000 1.000 1.000 

1100267000 11 Pear, dried 0.005000 1.000 1.000 

1100268000 11 Pear, juice 0.005000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.005000 1.000 1.000 

1100310000 11 Quince 0.005000 1.000 1.000 

1201090000 12A Cherry 0.005000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.005000 1.000 1.000 

1201091000 12A Cherry, juice 0.005000 1.000 1.000 

1201091001 12A Cherry, juice-babyfood 0.005000 1.000 1.000 

1202012000 12B Apricot 0.005000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.005000 1.000 1.000 
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 13 of 19

1202013000 12B Apricot, dried 0.005000 1.000 1.000 

1202014000 12B Apricot, juice 0.005000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.005000 1.000 1.000 

1202230000 12B Nectarine 0.005000 1.000 1.000 

1202260000 12B Peach 0.005000 1.000 1.000 

1202260001 12B Peach-babyfood 0.005000 1.000 1.000 

1202261000 12B Peach, dried 0.005000 1.000 1.000 

1202261001 12B Peach, dried-babyfood 0.005000 1.000 1.000 

1202262000 12B Peach, juice 0.005000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.005000 1.000 1.000 

1203285000 12C Plum 0.005000 1.000 1.000 

1203285001 12C Plum-babyfood 0.005000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.005000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.005000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.005000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.005000 1.000 1.000 

1203288000 12C Plum, prune, juice 0.005000 1.000 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.005000 1.000 1.000 

1304175000 13D Grape 0.005000 1.000 1.000 

1304176000 13D Grape, juice 0.005000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 0.005000 1.000 1.000 

1304179000 13D Grape, wine and sherry 0.005000 1.000 1.000 

1400003000 14 Almond 0.005000 1.000 1.000 

1400003001 14 Almond-babyfood 0.005000 1.000 1.000 

1400004000 14 Almond, oil 0.005000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.005000 1.000 1.000 

1400059000 14 Brazil nut 0.005000 1.000 1.000 

1400068000 14 Butternut 0.005000 1.000 1.000 

1400081000 14 Cashew 0.005000 1.000 1.000 

1400092000 14 Chestnut 0.005000 1.000 1.000 

1400155000 14 Hazelnut 0.005000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.005000 1.000 1.000 

1400185000 14 Hickory nut 0.005000 1.000 1.000 

1400213000 14 Macadamia nut 0.005000 1.000 1.000 

1400269000 14 Pecan 0.005000 1.000 1.000 

1400282000 14 Pistachio 0.005000 1.000 1.000 

1400391000 14 Walnut 0.005000 1.000 1.000 

1500120000 15 Corn, field, flour 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500120001 15 Corn, field, flour-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500121000 15 Corn, field, meal 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500121001 15 Corn, field, meal-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500122000 15 Corn, field, bran 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500123000 15 Corn, field, starch 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500123001 15 Corn, field, starch-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500124000 15 Corn, field, syrup 0.005000 1.500 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500124001 15 Corn, field, syrup-babyfood 0.005000 1.500 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500125000 15 Corn, field, oil 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500125001 15 Corn, field, oil-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500401000 15 Wheat, grain 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

1500401001 15 Wheat, grain-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

1500402000 15 Wheat, flour 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

1500402001 15 Wheat, flour-babyfood 0.005000 1.000 1.000 MRID 4
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 14 of 19

 Full comment: MRID 46587603 1/2 LOQ comb.

1500403000 15 Wheat, germ 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

1500404000 15 Wheat, bran 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

2003128000 20C Cottonseed, oil 0.020000 0.600 1.000 Proces

 Full comment: Processing study MRID45283014

2003128001 20C Cottonseed, oil-babyfood 0.020000 0.600 1.000 Proces

 Full comment: Processing study MRID45283014

3100044000 31 Beef, meat 0.001000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.001000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.001000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.001000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.001000 1.000 1.000 

3100047000 31 Beef, fat 0.001000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.001000 1.000 1.000 

3200169000 32 Goat, meat 0.001000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.001000 1.000 1.000 

3200171000 32 Goat, fat 0.001000 1.000 1.000 

3300189000 33 Horse, meat 0.001000 1.000 1.000 

3500339000 35 Sheep, meat 0.001000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.001000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.001000 1.000 1.000 

3500341000 35 Sheep, fat 0.001000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.001000 1.000 1.000 

3600222000 36 Milk, fat 0.001000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.001000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.001000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.001000 1.000 1.000 

3600224000 36 Milk, water 0.001000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.001000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.000295 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.000295 1.000 1.000 

9500177000 O Grape, leaves 0.005000 1.000 1.000 

9500178000 O Grape, raisin 0.005000 1.000 1.000 

9500188000 O Hop 0.010000 1.000 1.000 

9500235000 O Olive 0.005000 1.000 1.000 

9500236000 O Olive, oil 0.005000 1.000 1.000 

9500263000 O Peanut 0.010000 1.000 1.000 

9500264000 O Peanut, butter 0.010000 1.890 1.000 

9500265000 O Peanut, oil 0.010000 1.000 1.000 

9500289000 O Pomegranate 0.005000 1.000 1.000 

Cancer Residue File:
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 15 of 19

Filename: C:\Documents and Settings\krury\My Documents\My Work Files\Pyraflufen Ethyl\Hops 

and Peanuts\Dietary Assessment\Hops and Peanuts\Hops Peanuts CANCER revised dietary 

burden.R08

Chemical: Pyraflufen ethyl

RfD(Chronic): .2 mg/kg bw/day NOEL(Chronic): 20 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0332

Date created/last modified: 09-14-2012/15:32:20 Program ver. 3.16, 03-08-d

Comment: no acute tox endpoint; cancer water 0.268 ppb

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0103296000 1C Potato, chips 0.010000 1.000 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103297000 1C Potato, dry (granules/ flakes) 0.010000 6.500 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103297001 1C Potato, dry (granules/ flakes)-b 0.010000 6.500 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103298000 1C Potato, flour 0.010000 6.500 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103298001 1C Potato, flour-babyfood 0.010000 6.500 1.000 DER: 4

 Full comment: DER: 45283015 & 45283016

0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 

0600347000 6 Soybean, seed 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0600349000 6 Soybean, soy milk 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0600349001 6 Soybean, soy milk-babyfood or in 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0600350000 6 Soybean, oil 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0600350001 6 Soybean, oil-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0603348000 6C Soybean, flour 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

0603348001 6C Soybean, flour-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45643102 1/2 LOQ comb

1100007000 11 Apple, fruit with peel 0.005000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.005000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.005000 1.000 1.000 

1100009000 11 Apple, dried 0.005000 1.000 1.000 

1100009001 11 Apple, dried-babyfood 0.005000 1.000 1.000 

1100010000 11 Apple, juice 0.005000 1.000 1.000 

1100010001 11 Apple, juice-babyfood 0.005000 1.000 1.000 

1100011000 11 Apple, sauce 0.005000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.005000 1.000 1.000 

1100129000 11 Crabapple 0.005000 1.000 1.000 

1100210000 11 Loquat 0.005000 1.000 1.000 

1100266000 11 Pear 0.005000 1.000 1.000 

1100266001 11 Pear-babyfood 0.005000 1.000 1.000 

1100267000 11 Pear, dried 0.005000 1.000 1.000 

1100268000 11 Pear, juice 0.005000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.005000 1.000 1.000 

1100310000 11 Quince 0.005000 1.000 1.000 

1201090000 12A Cherry 0.005000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.005000 1.000 1.000 

1201091000 12A Cherry, juice 0.005000 1.000 1.000 

1201091001 12A Cherry, juice-babyfood 0.005000 1.000 1.000 

1202012000 12B Apricot 0.005000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.005000 1.000 1.000 

1202013000 12B Apricot, dried 0.005000 1.000 1.000 
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 16 of 19

1202014000 12B Apricot, juice 0.005000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.005000 1.000 1.000 

1202230000 12B Nectarine 0.005000 1.000 1.000 

1202260000 12B Peach 0.005000 1.000 1.000 

1202260001 12B Peach-babyfood 0.005000 1.000 1.000 

1202261000 12B Peach, dried 0.005000 1.000 1.000 

1202261001 12B Peach, dried-babyfood 0.005000 1.000 1.000 

1202262000 12B Peach, juice 0.005000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.005000 1.000 1.000 

1203285000 12C Plum 0.005000 1.000 1.000 

1203285001 12C Plum-babyfood 0.005000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.005000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.005000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.005000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.005000 1.000 1.000 

1203288000 12C Plum, prune, juice 0.005000 1.000 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.005000 1.000 1.000 

1304175000 13D Grape 0.005000 1.000 1.000 

1304176000 13D Grape, juice 0.005000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 0.005000 1.000 1.000 

1304179000 13D Grape, wine and sherry 0.005000 1.000 1.000 

1400003000 14 Almond 0.005000 1.000 1.000 

1400003001 14 Almond-babyfood 0.005000 1.000 1.000 

1400004000 14 Almond, oil 0.005000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.005000 1.000 1.000 

1400059000 14 Brazil nut 0.005000 1.000 1.000 

1400068000 14 Butternut 0.005000 1.000 1.000 

1400081000 14 Cashew 0.005000 1.000 1.000 

1400092000 14 Chestnut 0.005000 1.000 1.000 

1400155000 14 Hazelnut 0.005000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.005000 1.000 1.000 

1400185000 14 Hickory nut 0.005000 1.000 1.000 

1400213000 14 Macadamia nut 0.005000 1.000 1.000 

1400269000 14 Pecan 0.005000 1.000 1.000 

1400282000 14 Pistachio 0.005000 1.000 1.000 

1400391000 14 Walnut 0.005000 1.000 1.000 

1500120000 15 Corn, field, flour 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500120001 15 Corn, field, flour-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500121000 15 Corn, field, meal 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500121001 15 Corn, field, meal-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500122000 15 Corn, field, bran 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500123000 15 Corn, field, starch 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500123001 15 Corn, field, starch-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500124000 15 Corn, field, syrup 0.005000 1.500 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500124001 15 Corn, field, syrup-babyfood 0.005000 1.500 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500125000 15 Corn, field, oil 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500125001 15 Corn, field, oil-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 45666501 1/2 LOQ comb.

1500401000 15 Wheat, grain 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

1500401001 15 Wheat, grain-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

1500402000 15 Wheat, flour 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

1500402001 15 Wheat, flour-babyfood 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 17 of 19

1500403000 15 Wheat, germ 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

1500404000 15 Wheat, bran 0.005000 1.000 1.000 MRID 4

 Full comment: MRID 46587603 1/2 LOQ comb.

2003128000 20C Cottonseed, oil 0.020000 0.600 1.000 Proces

 Full comment: Processing study MRID45283014

2003128001 20C Cottonseed, oil-babyfood 0.020000 0.600 1.000 Proces

 Full comment: Processing study MRID45283014

3100044000 31 Beef, meat 0.001000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.001000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.001000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.001000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.001000 1.000 1.000 

3100047000 31 Beef, fat 0.001000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.001000 1.000 1.000 

3200169000 32 Goat, meat 0.001000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.001000 1.000 1.000 

3200171000 32 Goat, fat 0.001000 1.000 1.000 

3300189000 33 Horse, meat 0.001000 1.000 1.000 

3500339000 35 Sheep, meat 0.001000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.001000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.001000 1.000 1.000 

3500341000 35 Sheep, fat 0.001000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.001000 1.000 1.000 

3600222000 36 Milk, fat 0.001000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.001000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.001000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.001000 1.000 1.000 

3600224000 36 Milk, water 0.001000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.001000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.000268 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.000268 1.000 1.000 

9500177000 O Grape, leaves 0.005000 1.000 1.000 

9500178000 O Grape, raisin 0.005000 1.000 1.000 

9500188000 O Hop 0.010000 1.000 1.000 

9500235000 O Olive 0.005000 1.000 1.000 

9500236000 O Olive, oil 0.005000 1.000 1.000 

9500263000 O Peanut 0.010000 1.000 1.000 

9500264000 O Peanut, butter 0.010000 1.890 1.000 

9500265000 O Peanut, oil 0.010000 1.000 1.000 

9500289000 O Pomegranate 0.005000 1.000 1.000 

Chronic Results:

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for PYRAFLUFEN ETHYL NHANES 2003-2008 2-day
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 18 of 19

Residue file name: C:\Documents and Settings\krury\My Documents\My Work Files\Pyraflufen 

Ethyl\Hops and Peanuts\Dietary Assessment\Hops and Peanuts\Hops and Peanuts CHRONIC revised 

dietary burden.R08

 Adjustment factor #2 NOT used.

Analysis Date 09-14-2012/15:34:46 Residue file dated: 09-14-2012/15:34:08

Reference dose (RfD, Chronic) = .2 mg/kg bw/day

COMMENT 1: no acute tox endpoint; chronic water 0.295 ppb

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.000053 0.0%

Hispanic 0.000058 0.0%

Non-Hisp-White 0.000052 0.0%

Non-Hisp-Black 0.000051 0.0%

Non-Hisp-Other 0.000055 0.0%

Nursing Infants 0.000051 0.0%

Non-Nursing Infants 0.000132 0.1%

Female 13+ PREG 0.000045 0.0%

Children 1-6 0.000159 0.1%

Children 7-12 0.000079 0.0%

Male 13-19 0.000051 0.0%

Female 13-19/NP 0.000044 0.0%

Male 20+ 0.000039 0.0%

Female 20+/NP 0.000036 0.0%

Seniors 55+ 0.000035 0.0%

All Infants 0.000107 0.1%

Female 13-50 0.000039 0.0%

Children 1-2 0.000199 0.1%

Children 3-5 0.000143 0.1%

Children 6-12 0.000085 0.0%

Youth 13-19 0.000048 0.0%

Adults 20-49 0.000040 0.0%

Adults 50-99 0.000035 0.0%

Female 13-49 0.000039 0.0%

-------------------------------------------------------------------------------

Cancer Results:

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for PYRAFLUFEN ETHYL NHANES 2003-2008 2-day
Pyraflufen-ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 19 of 19

Residue file name: C:\Documents and Settings\krury\My Documents\My Work Files\Pyraflufen 

Ethyl\Hops and Peanuts\Dietary Assessment\Hops and Peanuts\Hops Peanuts CANCER revised 

dietary burden.R08

 Adjustment factor #2 NOT used.

Analysis Date 09-14-2012/15:35:46 Residue file dated: 09-14-2012/15:32:20

Q* = 0.0332 

COMMENT 1: no acute tox endpoint; cancer water 0.268 ppb

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Lifetime risk

 Subgroup body wt/day (Q*= .0332)

-------------------------------------- ------------- --------------

Total US Population 0.000052 1.74E-06

Hispanic 0.000058 1.92E-06

Non-Hisp-White 0.000052 1.71E-06

Non-Hisp-Black 0.000050 1.67E-06

Non-Hisp-Other 0.000055 1.82E-06

Nursing Infants 0.000051 1.68E-06

Non-Nursing Infants 0.000130 4.33E-06

Female 13+ PREG 0.000045 1.48E-06

Children 1-6 0.000158 5.26E-06

Children 7-12 0.000078 2.60E-06

Male 13-19 0.000051 1.69E-06

Female 13-19/NP 0.000044 1.46E-06

Male 20+ 0.000039 1.29E-06

Female 20+/NP 0.000035 1.17E-06

Seniors 55+ 0.000034 1.14E-06

All Infants 0.000106 3.51E-06

Female 13-50 0.000038 1.27E-06

Children 1-2 0.000198 6.57E-06

Children 3-5 0.000142 4.72E-06

Children 6-12 0.000085 2.81E-06

Youth 13-19 0.000047 1.57E-06

Adults 20-49 0.000039 1.30E-06

Adults 50-99 0.000034 1.14E-06

Female 13-49 0.000038 1.27E-06

-------------------------------------------------------------------------------