Exhibit 10.3



SUBLEASE



This SUBLEASE (the Sublease) is dated as of the 30th day of August, 2005 by and between BOSTON LIFE SCIENCES, INC., a Delaware corporation
(Sublandlord), and DELL MITCHELL ARCHITECTS, INC., a Massachusetts corporation (Subtenant).



RECITALS



WHEREAS, pursuant to that certain Lease dated as of January 28, 2002 by and between Brentwood Properties, Inc., a Delaware corporation (Prime
Landlord), as landlord, and Sublandlord, as tenant (the Prime Lease), a copy of which Prime Lease is attached hereto as Exhibit A, Sublandlord leased from Prime Landlord certain premises (the Original
Premises) located in the building commonly known as 20-24 Newbury Street, Boston, Massachusetts (the Building), which Original Premises contain approximately 6,600 rentable square feet of space located on the fourth and
fifth floors of the Building, as more fully described in the Prime Lease; and



WHEREAS, Subtenant desires to sublease from Sublandlord a portion of the Original Premises, comprising the fifth floor of the Building and containing 3,300 rentable square feet, more particularly shown on the floor plan attached
hereto as Exhibit B (the Subleased Premises), and Sublandlord is willing to sublease the Subleased Premises to Subtenant on the provisions, covenants and conditions hereinafter set forth.



AGREEMENT



NOW,THEREFORE, in consideration of Ten Dollars ($10.00), the mutual covenants
made herein, and other consideration, the receipt and sufficiency of which are hereby acknowledged and agreed, Sublandlord hereby subleases to Subtenant and Subtenant hereby takes and hires from Sublandlord the Subleased Premises, on the terms and
conditions set forth below:



I. Defined Terms.
All terms defined in the Prime Lease and used herein shall, unless otherwise defined herein, have the meanings ascribed to such terms in the Prime Lease.



II. Term. The term of this Sublease (the Sublease Term) shall commence on September 1, 2005 (the
Sublease Term Commencement Date), and shall continue until May 30, 2012 or the earlier termination of the Prime Lease, unless the Sublease Term is sooner terminated in accordance with the provisions of this Sublease. The
parties understand that Subtenant may enter into an agreement with Prime Landlord whereby Prime Landlord agrees to recognize Subtenant as its tenant upon termination of this Sublease in certain circumstances. If Sublandlord provides Subtenant with
access to the Subleased Premises prior to the Sublease Term Commencement Date, such access will be on all of the terms and conditions set forth in this Sublease.



III. Delivery. The Subleased Premises shall be delivered to Subtenant on the Sublease Term Commencement
Date, broom-clean and free of all occupants but otherwise as-is, where-is and with all faults, without representation or warranty, express or implied, and Subtenant hereby waives, disclaims and renounces any representation or warranty.
In the event construction of any demising walls are necessary to separately demise the Subleased Premises, the same will be constructed by Subtenant at its sole cost and expense, in accordance with and subject to the provisions of this Sublease and
the provisions of the Prime Lease incorporated herein. Sublandlord



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shall have no obligation to make any improvements in or to the Subleased Premises. Subtenant shall be responsible for reconfiguring the Premises to suit its
specific use program, subject to the provisions of the Prime Lease and this Sublease. Sublandlord has approved the plans and specifications attached hereto as Exhibit C, but the same remain subject to Prime Landlord approval.



IV. Base Rent. Commencing on March 16, 2006, and on
the first of each month thereafter, Subtenant shall pay to Sublandlord, in advance, monthly installments, without withholding, offset or reduction, of base rent (Base Rent) at the rate set forth below.



|                                                         |  |                                                     
|-------------------------------------------------------- |  | ----------------------------------------------------
|Dates                                                    |  | Base Rent                                           
|For the period from March 16, 2006 through May 30, 2009: |  | The annual rate of $105,600 (i.e., $8,800 per month)
|                                                         | 
|For the period from June 1, 2009 through May 30, 2012:   |  | The annual rate of $115,500 (i.e. $9,625 per month) 



V.
Additional Rent. Subtenant acknowledges that pursuant to Sections 3.02, 3.03, 3.04 and 3.05 of the Prime Lease, Sublandlord is obligated to pay to Prime Landlord additional rent on account of operating costs, insurance and real estate
taxes, as more particularly described in such Sections. Subtenant shall pay to Sublandlord with its monthly payment of Base Rent Subtenants proportionate share of Sublandlords additional rent obligations under Sections 3.02, 3.03, 3.04
and 3.05 of the Prime Lease (but in the case of Sections 3.02 and 3.03 (and 3.05 as it applies to Sections 3.02 and 3,03), only to the extent such rental amounts exceed those due in the calendar year ending December 31, 2005, and in the case of
Section 3.04 (and Section 3.05 as it applies to Section 3.04), only to the extent such rental amounts exceed those due on account of fiscal year ending June 30, 2006) Subtenants proportionate share as used in the preceding
sentence is 50% (being the number of rentable square feet in the Subleased Premises expressed as a percentage of the number of rentable square feet in the Original Premises, referred to hereinafter as Subtenants Proportionate
Share). Sublandlord shall deliver to Subtenant promptly after receipt thereof any statements of operating costs, insurance or real estate taxes delivered to Sublandlord by Prime Landlord. Sublandlord agrees, at Subtenants sole cost
and expense, to exercise its right, pursuant to Section 3.02 of the Prime Lease, to review Landlords books and records with respect to any such statement if so requested by Subtenant within the time allowed under such Section 3.02 of
the Prime Lease.



VI. Use. The Subleased
Premises shall be used for general office use and for no other uses. To the extent permitted by the Prime Lease, and subject to the provisions of the Prime Lease and this Sublease, Subtenant shall have access to the Subleased Premises 24 hours a
day, 365 days a year at all times during the Sublease Term.



VII. Prime Lease. Subtenant agrees that it will do nothing in, on or about the Subleased Premises which would result in the breach by Sublandlord of its undertakings and obligations under the Prime Lease. Except for the
following provisions, this Sublease shall be subject to and on all of the terms and conditions as are contained in the Prime Lease and the provisions of the Prime Lease are hereby incorporated into this Sublease as if Sublandlord were the landlord
thereunder and Subtenant the tenant thereunder:



| | A. | The defined economic terms for Yearly Fixed Rent, Monthly Payment, Rent Year, Leased Area, Term Commencement Date,
Rent Commencement Date, Rent Year and the like are inapplicable;
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| | B. | Sections 3.02, 3.03, 3.04 and 3.05 of the Prime Lease (relating to additional rent) are applicable, as modified by the provisions of Paragraph V of this Sublease;
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| | C. | Article IV of the Prime Lease (relating to construction of the premises) is inapplicable;
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| | D. | Article V of the Prime Lease (relating to utilities) is applicable, as clarified by Section XIV hereof;
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| | E. | Section 14.07 of the Prime Lease (relating to security deposits) is inapplicable;
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| | F. | Section 14.12 of the Prime Lease (relating to brokerage) is inapplicable;
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| | G. | Section 14.14 of the Prime Lease (relating to extension options) is inapplicable; and
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| | H. | Where appropriate, references to Landlord in the Prime Lease shall be deemed to mean Sublandlord hereunder and references to Tenant in the Prime
Lease shall be deemed to mean Subtenant hereunder, it being understood and agreed that Sublandlord will not be acting as, or assuming any of the responsibilities of, Prime Landlord, and all references in the Prime Lease to
Landlord-provided services or Landlord insurance requirements, and any other references which by their nature relate to the owner or operator of the Building, rather than to a tenant of the Building subleasing space to a subtenant, shall continue to
be references to Prime Landlord and not to Sublandlord.
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Sublandlord covenants to Subtenant to perform all of the terms and provisions required of it under the Prime Lease and to promptly pay when due all rents, including any and all additional rents, due and accruing to Prime Landlord, provided
Subtenant timely makes all rental and additional rental payments required of Subtenant hereunder. Upon request of Subtenant and at Subtenants cost and expense, Sublandlord will use reasonable efforts to enforce on behalf of Subtenant
Sublandlords rights under the Prime Lease. Nothing contained in this Sublease shall be construed as a guarantee by Sublandlord of any of the obligations, covenants, warranties, agreements or undertakings of Prime Landlord in the Prime Lease,
nor as an undertaking by Sublandlord to Subtenant on the same or similar terms as are contained in the Prime Lease.



VIII. Subtenants Covenants. Subtenant covenants to Sublandlord to perform all of the covenants and obligations to be performed
by Sublandlord as tenant under the Prime Lease as the same relate to the Subleased Premises and to comply with this Sublease and the applicable provisions of the Prime Lease, as modified by this Sublease, in all respects (including, without
limitation, complying with all applicable laws, regulations and standards). If Subtenant shall fail to



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make any payment or perform any act required to be made or performed by Subtenant under the Prime Lease pursuant to Subtenants assumption of
Sublandlords obligations thereunder as they relate to the Subleased Premises, and such default is not cured by Subtenant by the first to occur of (i) one-half of the period specified in the Prime Lease for curing such default (which will
include one-half of the longer period as may be necessary granted in clause (b) of Article XI of the Prime Lease, if such longer period is granted to Sublandlord in the particular situation), or (ii) five
(5) days prior to the expiration of such Prime Lease cure period, Sublandlord, without waiving or releasing any obligation or default hereunder, may (but shall be under no obligation to) make such payment or perform such act for the account and
at the expense of Subtenant, and may take any and all such actions as Sublandlord in its sole discretion deems necessary or appropriate to accomplish such cure. If Sublandlord shall reasonably incur any expense in remedying such default, Sublandlord
shall be entitled to recover such sums upon demand from Subtenant as additional rent under this Sublease.



IX. Omitted.



X. Indemnification. Subtenant shall indemnify Sublandlord and hold Sublandlord harmless from and against any and all claims, demands
suits, judgments, liabilities, costs and expenses, including reasonable attorneys fees, arising out of or in connection with Subtenants use and possession of the Subleased Premises, or arising out of the failure of Subtenant, its agents,
contractors or employees to perform any covenant, term or condition of this Sublease or of the Prime Lease to be performed by Subtenant hereunder, except in each case to the extent any such claim, demand, suit, judgment, liability, costs or expense
arises as a result of the negligence or willful misconduct of Sublandlord. Sublandlord shall indemnify Subtenant and hold Subtenant harmless from and against any and all claims, demands, suits, judgments, liabilities, costs and expenses, including
reasonable attorneys fees, arising out of the failure of Sublandlord or its agents, contractors or employees to perform any covenant, term or condition of this Sublease or of the Prime Lease to be performed by Sublandlord hereunder, except in each
case to the extent any such claim, demand, suit, judgment, liability, costs or expense arises as a result of the negligence or willful misconduct of Subtenant.



XI. Assignment and Subletting. Subtenant shall not assign this Sublease in whole or in part or sublet the Subleased Premises in
whole or in part, except in compliance with the provisions of the Prime Lease which are incorporate herein, as set forth above, as if Sublandlord were Landlord and Subtenant were Tenant thereunder, including the obtaining of
consents required thereunder. Additionally, no such sublease or assignment shall be effective without the consent of Prime Landlord under the Prime Lease. If, as to any sublease or assignment for which Sublandlords consent is necessary,
Subtenant receives rent or other consideration in excess of the Base Rent and additional rent payable under this Sublease, Subtenant shall pay to Sublandlord one-half of such excess, after deducting Subtenants reasonable legal and brokerage
expenses and fit-up expenses paid for by Subtenant at the time of such subleasing or assignment. Sublandlord shall not unreasonably withhold its consent to any proposed assignment or sublease if such assignment or sublease is approved by Prime
Landlord. If Sublandlord and Prime Landlord consent to any such assignment or subletting, Subtenant shall remain fully and primarily liable to Sublandlord, in all respects, under the Sublease.



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XII.Security Deposit. Upon execution hereof, Subtenant has delivered to Prime
Landlord the amount of $26,400.00 (Subtenants Security Deposit), such sum to be held by Prime Landlord as security for the performance of Subtenants obligations under this Sublease. Upon the occurrence of any default
by Subtenant hereunder beyond applicable notice and grace periods, Subtenant agrees that Sublandlord and/or Prime Landlord may apply all or any part of Subtenants Security Deposit, together with accrued interest, if any, to any obligation of
Subtenant hereunder. If all or any portion of Subtenants Security Deposit is applied by Sublandlord and/or Prime Landlord against any of Subtenants obligations hereunder, Subtenant shall promptly restore Subtenants Security Deposit
to its original amount. Interest actually earned on Subtenants Security Deposit shall, on an annual basis, be credited to and become part of the Subtenants Security Deposit. If Subtenant shall have complied with its obligations under the
Sublease, Subtenants Security Deposit, or any unapplied balance thereof, shall be returned to Subtenant within thirty (30) days after the time fixed as the expiration of the Sublease Term hereof and the yield up and surrender by Subtenant
of the Subleased Premises in accordance with the provisions of the Sublease. If Sublandlord assigns its interest in this Sublease, it will also assign its interest in the Subtenants Security Deposit, or any unapplied portion thereof, to the
assignee. Upon such delivery, the Sublandlord named herein will be released of all obligations with respect to the Subtenants Security Deposit.



XIII. Brokers. Each of Sublandlord and Subtenant represents and warrants to the other that it has not dealt with any broker in
connection with this Sublease other than GVA Thompson, Doyle, Hennessey & Stephens and Gregg Jordan & Associates (collectively, the Brokers), and each agrees to indemnify, defend and hold the other harmless from and
against any breach of said representation and warranty. Sublandlord shall be responsible for any commission which may be due to the Brokers pursuant to a separate agreement between Sublandlord and such Brokers.



XIV. Utilities. Subtenant shall be responsible for all
utilities (including light, plug and HVAC electricity and gas) in the Subleased Premises, to be paid by Subtenant to Sublandlord within ten (10) business days after Subtenants receipt of a bill from Sublandlord for such amount.
Sublandlord will include with such bill to Subtenant copies of any bills or invoices Sublandlord received with respect to such utility payment. Subject to Subtenants obligation to make timely payment of Subtenants share of any such
utility bills, and except as set forth in the last sentence of this paragraph, Sublandlord covenants and agrees that Sublandlord shall pay all utility bills to the utility provider or to Prime Landlord, as applicable, in a timely fashion so as to
avoid any interruption in utility service to the Subleased Premises. Subtenants payment obligation hereunder shall be equal to the utility costs for the Subleased Premises if separately metered or fifty percent (50%) of the utility costs
for the Original Premises if not separately metered. Notwithstanding the foregoing, to the extent any utility is separately metered to the Subleased Premises, Subtenant will purchase and receive such utility directly from the public utility or other
company designated by Prime Landlord.



XV.
Miscellaneous.



| | A. | Counterparts. This instrument may be signed in counterpart originals, which, taken together, shall constitute a single original instrument.
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| | B. | Notices. Notices to Sublandlord or Subtenant required or permitted hereunder shall be sent in the manner prescribed in the Prime Lease to the address set forth below in the
case of notices to Sublandlord and to the Subleased Premises in the case of notices to Subtenant. Except with respect to notices of default and cure periods with respect to any default, which shall be governed by the provisions of Section VIII
hereof, any time periods for the giving or receiving of notices (or the taking of actions following the giving or receiving of notices) set forth in the Prime Lease shall, as incorporated herein, be three (3) business days longer in the case of
notices from Sublandlord to Subtenant, and three (3) business days shorter in the case of notices from Subtenant to Sublandlord.
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Notice address for Sublandlord:



Boston Life Sciences, Inc.

85 Main Street

Hopkinton, MA 01748

Attention: Ken Rice



| | C. | Consents. Without derogating from the other provisions hereof, it is acknowledged that in any instance in which Prime Landlords consent is required under the Prime
Lease, both Prime Landlord and Sublandlords consent will be required hereunder.
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| | D. | Amendments. This Sublease may not be changed or terminated orally but only by an agreement in writing signed by both Sublandlord and Subtenant.
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| | E. | Signage. Subject to Landlords approval and the provisions of the Prime Lease, Subtenant may, at Subtenants cost and expense, have its name listed in the lobby
directory, on the entrance to the Subleased Premises and on 50% of that portion of each side of the exterior sign for the Building currently allocated to Sublandlord.
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| | F. | Estoppel Certificates. Sublandlord and Subtenant each agree to furnish within twenty (20) days after written request therefor by the other, a certificate stating
(i) that this Sublease is in full force and effect and has not been amended or modified (or describing such amendment or modification, if any); (ii) the dates through which Base Rent and additional rent have been paid hereunder; and
(iii) that there are no defaults under this Sublease known to the signer of the certificate (or specifying such defaults, if known).
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| | G. | No Waiver. The failure of either party to insist on strict performance of any covenant or condition hereof, or to exercise any option contained herein, shall not be construed
as a waiver of such covenant, condition or option in any other instance.
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| | H. | Memorandum of Lease. Subtenant shall not record this Sublease or any memorandum or notice hereof.
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| | I. | Governing Law. This Sublease has been negotiated, executed and delivered in the Commonwealth of Massachusetts, and the parties agree that the rights and obligations of the
parties under this Sublease shall be governed and construed in accordance with the laws of the Commonwealth of Massachusetts.
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| | J. | Severability. The invalidity of any of the provisions of this Sublease will not impair or affect in any manner the validity, enforceability or effect of the rest of this
Sublease.
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| | K. | Entire Agreement. All understandings and agreements, oral or written, heretofore made between the parties hereto are merged in this Sublease, which alone fully and completely
expresses the agreement between Sublandlord and Subtenant.
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| | L. | Relationship Between the Parties. This Sublease does not create the relationship of principal and agent, nor does it create any partnership, joint venture, or any association
or relationship between Sublandlord and Subtenant other than as and to the extent specifically provided in this Sublease, the sole relationship of Sublandlord and Subtenant being that of sublandlord and subtenant as provided in this Sublease.
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| | M. | Remedies Cumulative. Except as specifically provided herein, all rights and remedies of Sublandlord under this Sublease shall be cumulative and none shall exclude any other
rights and remedies allowed by law.
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| | N. | Condition Precedent. The effectiveness of this Sublease is expressly subject to and conditional upon obtaining Prime Landlords written consent to this Sublease pursuant
to Article VIII of the Prime Lease.
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IN WITNESS WHEREOF, the parties have executed this Sublease as an instrument under seal as of the date first written
above.



SUBLANDLORD:BOSTON LIFE SCIENCES, INC., a DelawarecorporationBy:

/s/    MARK J. PYKETTName:

Mark J. PykettTitle:

President and COOSUBTENANT:DELL MITCHELL ARCHITECTS, INC., aMassachusetts corporationBy:

/s/    DELL MITCHELLName:Title:

President




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EXHIBIT A



PRIME LEASE



[See Attached]



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EXHIBIT B



FLOOR PLAN SHOWING

SUBLEASED PREMISES



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