### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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## C ancer Dietary (Food and Drinking Water) Exposure Results and Chara cterization

Pyraflufen

- ethyl is classified as “likely to be carcinogenic to humans” by the oral route ;

t herefore, a cancer dietary risk assessment is required. All exposure inputs were the same as the chronic dietary exposure assessment for the cancer assessment, except the EDWC. Chronic cancer dietary exposure from drinking water was determined based on a Tier 2 (surface water) drinking water estimate provided by EFED. The EDWC estimate (30

- year average) value of 0.268 ppb for the combined residues of pyraflufen

- ethyl and its metabolic products, E

- 1, E

- 2, and E

- 3 were incorporated directly into the dietar y assessment to estimate carcinogenic risk from drinking water containing pyraflufen

- ethyl.

The cancer chronic dietary (food and water) exposure to pyraflufen

- ethyl is 2x10 - 6



## .

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasona ble adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD ; i.e., no observed adverse effect level: NOAEL) divided by the required uncertainty or safety factors.

For acut e and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk
exceeds one in one m illion

. References which discuss the acute and chronic risk
assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000,
web link: http://www.epa.go v/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 ( 20

- AUG

- 1999 ).

The most recent dietary risk assessment for pyraflufen

- ethyl was conducted by Leung Cheng ( D378643, 02/08/2011 ).

II. Residue Information

Pyraflufen

- ethyl [ethyl 2

- chloro

- 5

- (4

- chloro

- 5

- difluoromethoxy

- 1

- methyl

- 1 H

- pyrazol

- 3

- yl)

- 4

- fluorophenoxyacetate], is a herbicide defoliant for which permanent tolerances have been established [40 CFR§180.585(a)] for the combined residues of pyraflufen

- ethyl and
its acid metabolit e E

- 1 [2

- chloro

- 5

- (4

- chloro

- 5

- difluoromethoxy

- 1

- methyl

- 1 H

- pyrazol

- 3

- yl)

- 4

- fluorophenoxyacetic acid], in almond hulls, corn, cotton, pome fruits, grapes, grass forage and hay, tree nuts, olives, pistachios, pomegranates, potatoes, soybeans, stone fruit, and wheat

. Time limited t olerances of 0.02 ppm have been established for residues
in milk and in the meat byproducts of cattle, goat, horse, and sheep (expiration date: 10/15/12)

.

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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## Residues of Concern: HED has concluded that the residues of concern in /on pl ants for
tolerance enforcement and risk assessment includ e the parent and Metabolite E

- 1 . The
residues of concern in livestock commodities are the parent, Metabolite E

- 1, and
Metabolite E

- 9 [2

- chloro

- 5

- (4

- chloro

- 5

- difluoromethoxy

- 1 H

- pyrazol

- 3

- yl)

- 4

- fluo ro phenoxyacetic acid].

Plant commodities: Tolerances have been established for the combined residues of pyraflufen

- ethyl and its acid metabolite E

- 1 at levels ranging from 0.01 ppm in/on
various agricultural commodities to 1.5 ppm in/on cotton gin byprodu cts [40 CFR§180.585(a) ] . Average crop field trial data ( 1⁄2 of the combined LOQ for the parent and the metabolites) were used in the DEEM

- FCID analyses for the following commodities: corn, cottonseed, potato, soybean, wheat, pome fruit, stone fruit,

pomegra nate, olive, grape, tree nuts, and pistachio. All other established and proposed commodities were analyzed using tolerance

- level residues.

Processed Commodities: Because the commodity

- specific processing studies did not
show concentration of pyraflufen

- ethyl from processing, the chronic dietary exposure assessment did not incorporate processing factors for the following commodities: treated corn grain, soybean seeds, wheat grain, apples, and grapes. S ample chromatograms for treated apples and grapes also showed no difference from the untreated control samples. Processing data for apples and grapes may be extrapolated to stone fruits. Therefore, the
concentration factors were assumed to be 1X fo r the processed commodities of pome fruit, grape s, and stone fruit. However, default processing factors were used for dry potatoes (6.5X), dried beef (1.92X), peanut butter (1.89X), and corn syrup (1.5X). An empirical processing factor of 0.6X was used for cotton seed oil.

Livestock commodities : The livestock dietary burdens of pyraflufen

- ethyl, based on maximum reasonably balanced diets (MRBD ), were recently calculated by L. Cheng (D377361, 02/07/2011). The beef and dairy cattle dietary burdens were recalculated for the proposed uses of pyrafluf en

- ethyl on hops and peanuts. The calculated dietary
burdens are 0. 1 2 ppm for beef cattle (versus 0.25 ppm)

, 0.76 ppm for dairy cattle (versus 1.8 ppm) , 0.01 ppm for swine, and 0.01 ppm for poultry. The dietary burden calculations
reflect established tol erances for corn, cotton, grass, soybean, and wheat commodities. Based on the calculated dietary burdens and a revision of the original cattle feeding study
to include residue data for Metabolite E

- 9, HED recommended the establishment of tolerances for the combined residues of pyraflufen

- ethyl, Metabolite E

- 1, and Met abolite

E

- 9 in milk, and the fat, meat

, and meat byproducts of cattle, goat, horse, and sheep at the combined LOQ of 0.0 01 ppm. HED concluded that the tolerances for poultry and hog commodities were not required because there is no reasonable expectation of finite residues in poultry or hog commodities. H orse meat byproduct s are not included in the food consumption data from the USDA’s NHANES/WWEIA. Based on the relatively minor expected dietary contribution from peanut hay and meal to livestock diets (r elative to more significant contributors, including corn, cotton, and grass), and the anticipated reduction in dietary burdens in general resulting from the change in values used in the calculations, HED does not believe that the addition of the proposed u ses on peanut and hops will have an impact on the recommended tolerances for ruminant commodities, and

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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Page 5 of 19 

## will not affect the currents status of no tolerances needed for poultry and hog commodities. This conclusion is subject to revision upon submission of a dditional peanut bridging field trial study results.

Table 1: Dietary Burdens of Pyraflufen

- ethyl + E1 Residues to Livestock for Chronic & Cancer
Assessment

.

Feedstuff Type 1 

### % Dry

Matter 2 

### % Diet 2 

### Residue Dietary Contribution (ppm) 3 

### Value used ppm

Beef Cattle (R 15%, CC 75%, and PC 10%) 2



### Grass, hay R 88 10 Median 4 

### 0.612 0.070
Cotton, gin byproducts R 90 5 Median 4 

### 0.712 0.040
Corn, field, grain/milled byproducts CC 88 75 Tolerance 0.01 0.009

Soybean, meal PC 92 10 Tolerance 0.01 0.001

TOTAL BURDEN

-- -- 100 0.12
Dairy Cattle (R 45%, CC 45%, and PC 10%) 2



### Grass, forage/silage R 25 45 Median 4 

### 0.416 0.748
Corn, field, grain/milled byproducts CC 88 45 Tolerance 0.01 0.005

Cotton, undelinted seed PC 90 10 Tolerance 0.04 0.004

TOTAL BURDEN

-- -- 100 0.76

1 

### R: Roughage; CC: Carbohydrate concentrate; PC: Protein concentrate.

2 

### OPPTS 860.1000 Table 1 Feedstuffs (June 2008).

3 

### Contribution = ([ residue /% DM] X % diet) for beef and dairy cattle; contribution = ( residue ] X % diet) for poultry and swine.

4 

### D339032 & D320103.



## Previous Reviews: A proposed use on hops was incorporated into the previous chronic and cancer aggregate dietary exposure at 0.05 ppm (L. Cheng, D378643, 02/08/2011) ; h owever, the previous request for use on hops was not granted . In the interim, a new petition was submitted with a proposed tolerance of 0.01 ppm, and HED has updated

DEEM

- FCID to incorporate more recent dietary survey data ; t herefore, the proposed use on hops has been reevaluated here along with the proposed peanut use

.

Residue Data used for Chronic and Cancer Assessments:

The chronic and cancer dietary analyses were conducted for pyraflufen

- ethyl incorporating exposure estimates from use on food and through drinking water. Al l available pyraflufen

- ethyl field trials showed residues < LOQ ; t herefore, the chronic dietary exposure assessment incorporated 1⁄2 of the combined LOQ for the parent and the metabolites for the following commodities: corn, cottonseed, potato, soybean, whea t, pome fruit, stone fruit, pomegranate, olive, grape, tree nuts, and pistachio. All other established and proposed commodities were analyzed using tolerance

- level residues. Because the commodity

- specific processing studies did not show pyraflufen

- ethyl concentration, the chronic dietary exposure assessment did not incorporate processing factors for the following commodities: corn grain (however, corn syrup data was not

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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Page 6 of 19 

## provided) , soybean seeds, wheat grain, apples, and grapes. However, default processi ng factors were used for dry potatoes (6.5X), peanut butter (1.89X), dried beef (1.92), and corn syrup (1.5X). An empirical processing factor of 0.6X was used for cotton seed oil.

The food residue data used in the chronic analyses are summarized below in Table 2

.

Table 2 : Residue Data used in the Chronic Dietary Analyses for Pyraflufen

- ethyl.

Commodity Residue

Level Percent

Crop

Treated Reference/Basis of Calculated Anticipated Residues or Feeding Level

Corn, field, grain * 0.005 100 DEEM default processing factor of 1.5x was used for corn

syrup Cottonseed 0.02 100 0.6x e mpirical processing factor for cottonseed oil Grape * 0.005 100 Processing factors were set to 1 Hops 0.01 100 Proposed commodity

Olive * 0.005 100

Pome fruit * 0.005 100 Processing factors were set to 1 Pomegranate * 0.005 100

Potato 0.01 100 DEEM default processing factor of 6.5x was used for dried potatoes and potato flour

Peanuts 0.01 100 Proposed Commodity , DEEM default processing factor of 1.89X used for peanut butter

Pistachio * 0.005 100
Soybean, seed * 0.005 100

Stone fruit * 0.005 100 Processing factors were set to 1

Tree nuts * 0.005 100
Wheat, grain * 0.005 100

Fat# 0 .001 Extrapolation of feeding study results at the 9.8 ppm dose to a dietary burden of 0.76 ppm

Milk 0.001 Extrapolation of feeding study results at the 9.8 ppm dose to a dietary burden of 0.76 ppm

Meat#
0.0 01 100 Extrapolation of feeding study results at the 9.8 ppm dose to a dietary burden of 0.76 ppm ; Dried beef processing factor
1.92X Meat byproducts^ 0.0 0 1 100 Extrapolation of feeding study results at the 9.8 ppm dose to a dietary burden of 0.76 ppm



### * 1⁄2 LOQ of combined residues of parent and metabolite E

- 1. # of cattle, goat, horse, and sheep. ^ of cattle, goat, and sheep



## III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED (M. Barrett, D402766, 09/21/2012) . The proposed use on peanuts did not change the EDWCs provided in the last drinking water assessment (M. Barrett, D377360, 03/23/2011) . The EDWCs were incorporated directly into this dietary exposure

assessment. Water residues were incorporated in the DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” Tier 2 EDWCs

w ere calculated using the Pesticide Root Zone Model ( PRZM

- EXAMS , version 2.98.04).
Water residues of 0.295 ppb and 0.268 ppb were incorporated directly DEEM

- FCID into the categories “water, direct, all sources” and “water, indirect, all sources” for the chronic

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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Page 7 of 19 

## and cancer dietary exposure assessment, respectively. The EDWCs calculated using

PRZM

- EXAMS (surface water) and SCI

- GR OW (groundwater) for use in the human health risk assessment are presented in Table 3 . The models and their descriptions are
available at the EPA internet site: http://www.epa.gov/oppefed1/models/wat er/

.

Table 3 : Tier II EDWCs for Pyraflufen

- ethyl, E

- 1, E

- 2, and E

- 3 (as Parent + E

- 1 and as total residues).

Exposure
Duration Nature of Residue /

-- EDWC (as μ g/L or ppb )

--

Parent + E

- 1 *1 Total residues (Recommended) *2 Total Residues (Experimental Estimate) *3

Peak 0.425 *6
(FL Cucumber)
0.420 (ME Potato) 0640 *6
(ME Potato)
0.589 (FL cucumber) NC

Annual Average 0.127 (ID Potato) 0.295 (Assumes E

- 1 dominant; ID Potato)

0.284 (Assumes E

- 3 dominant; ME Potato) NC

30

- year Average 0.117 (ID Potato) 0.268 (Assumes E

- 1 dominant; ID Potato)

0.222 (Assumes E

- 3 dominant; ME Potato) 0.198 (ID Potato)

Acute/Chronic (Ground Water) 0.0014 (Potato) 0.0018 *5
(Potato) ---

1 Residues of E

- 1 are expected to be the predominant component in these estimates, but the estimation procedure is inclusive of parent residu es.

2 For chronic exposure (annual and longer periods), model inputs designed to calculate chronic exposure to total residues most accurately (assumes E

- 3 is likely the dominant long

- term environmental residue). For acute exposure, estimates assumed all residues were as mobile as E

- 1, the dominate residue for short duration exposure.

3 Calculates residues from fo rmulation and decline aspect using PRZM

- EXAMS routines still in development and currently not approved for in risk assessments. This particular method assumed that E

- 1 is a more dominant environment residue than parent pyraflufen ethyl and that E

- 3 is more
dominant than E

- 3 as a long

- term residue (therefore utilizing aggregate decline constants for parent + E

- 1 and aggregate formation and decline
constants for E

- 2 + E

- 3). Note that, due to a programming error in PRZM the 1.0000 fractional conversion was en tered as 0.6931 fractional which appears to entirely correct the error.

NC = Not calculated (separate post

- processing of daily time series estimated values for parent and degradates would be calculated

– this was not performed since these values from this experimental assessment method were not needed for reference in this review.)

4 Thirty years simulation, representative of lifetime exposure.

5 E

- 2 + E

- 3 estimated to be 0.00038 ppb.

6 For Peak exposure the estimates for each of the two highest scenarios is given (FL cucumber and ME potato) for Parent +E

- 1 residues and for total
residues.



## IV. DEEM

- FCID Program and Consumption Information

Pyraflufen

- ethyl acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake

Da tabase DEEM

- FCID, Version 3 .1 6

, which incorporates consumption data from
USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over

two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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Page 8 of 19 

## EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S; baked ; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population

su bgroups, but for acute exposure assessment are retained as individual consumption events. Based on analysis of the 2003

- 200 8 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50+ years old.

For chronic dietary exposure ass essment, an estimate of the residue level in each food or
food

- form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue
intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weigh t/day and as a percent of the chronic population adjusted dose ( cPAD ) . This procedure is performed for each population subgroup.

V. Toxicological Information

The pyraflufen

- ethyl risk assessment team confirmed endpoints that were previously selected for pyraflufen

- ethyl in the most recent risk assessment (K. Rury, D377359, 03/01/2011). The toxicological PODs selected for dietary exposure are summarized in
Tabl e 4

. An appropriate endpoint attributable to a single oral dose was not available, and
therefore an acute reference dose ( RfD ) was not established. The Food Quality Protection Act (FQPA) safety factor was reduced to 1X because pyraflufen

- ethyl showed

no evidence of increased susceptibility of the young. Pyraflufen

- ethyl is classified as “likely to be carcinogenic to humans.” Therefore, a linear low

- dose extrapolation (Q 1 * 

## of

3.32x10 - 2 

## ( mg/kg/day ) - 1 

## ) is used for quantification of human cancer risk from th e oral (dietary) route of exposure.

Table 4 : Summary of Toxicological Doses and Endpoints for Pyraflufen

- Ethyl for Use in Dietary Human Health

Risk Assessments.

Exposure/
Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD, PAD,

Level of
Concern for
Risk
Assessment Study and Toxicological Effects

Acute Dietary (all popula tions) None None None An endpoint attributable to a single dose
was not identified from the available data.

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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Page 9 of 19 Table 4 : Summary of Toxicological Doses and Endpoints for Pyraflufen

- Ethyl for Use in Dietary Human Health

Risk Assessments.

Exposure/
Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD, PAD,

Level of
Concern for
Risk
Assessment Study and Toxicological Effects

Chronic Dietary (all populations) NOAEL =

20 UF A =10X

UF H =10X FQPA SF = 1X Chronic

RfD = 0.20 mg/kg/day

cPAD = 0.2 mg/kg/day Mouse Carcinogenicity

LOAEL = 98 mg/kg/day based on liver toxicity

Cancer (oral, dermal, inhalation) Classification: “Likely to be Carcinogenic to Humans” by the oral route

.

Q 1 * = 3.32 x 10
- 2 (mg/kg/day)

- 1

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (i nterspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (c = chronic). RfD = reference dose.



## VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk
exceeds 100% of the PAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 5 are for the gene ral U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5,
children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50+ years. Cancer risk is determined for the general U.S. population only.

Acute Dietary Exposure Results and Characterization

Pyraflufen

- ethyl does not require an acute dietary exposure assessment since a toxicological endpoint attributable to a single dose was not identified from the available
data.

Results of Chronic Dietary ( Food and Drinking Water) Exposu re Analy s is

The results of the chronic dietary exposure analysis are reported in the T able 5

. The non

cancer chronic dietary (food and drinking water) exposure analysis was a partially refined assessment which assumed that 100% of the crop was treated. Based on the assumptions described above (Section II), chronic dietary exposure estimates are no t of concern to HED (i.e., <100% of the cPAD of 0.2 mg/kg/day). The combined chronic dietary exposure estimates are <1% for the general U.S. population and all the population subgroups, including children 1

- 2 years old, the most highly exposed population subgroup.

Results of Cancer Dietary (Food and Drinking Water) Exposure Analy s is

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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Page 10 of 19 

## The results of the cancer dietary exposure analysis are reported in the Table 5

. The estimated exposure of the general U.S. population to pyraflufen

- ethyl is 0.000075 mg/kg/day. Applying the Q1* of 3.32x10 - 2 

## (mg/kg/day ) - 1 

## to the exposure value results in

a cancer estimate of 2x 10 - 6



## . Therefore, estimated cancer risk is not of concern to HED.

Table 5 : Summary of Dietary (Food and Drinking Water) Exposure and Risk for Pyraflufen

- ethyl.

Population Subgroup Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % cPAD 1 Dietary Exposure (mg/kg/day) Risk

General U.S. Population 0. 000053 <1.0% 0. 000052 2x10
- 6

All Infants (< 1 year old) 0. 00012 <1.0%

N/A N/A Children 1

- 2 years old 0. 0002 0 <1.0%

Children 3

- 5 years old 0. 00014 <1.0%

Children 6

- 12 years old 0. 000085 <1.0%

Youth 13

- 19 years old 0. 000048 <1.0%

Adults 20

- 49 years old 0. 000040 <1.0%

Adults 50+ years old 0. 000035 <1.0%

Females 13

- 49 years old 0. 000039 <1.0%

1. 

### Highest exposure is in bold.



## VII. Characterization of Inputs/Outputs

The chronic dietary exposure analysis is partially refined in that 1⁄2 the combined LOQs of the parent and metabolites are used for the residue values in the dietary assessment, rather than the established tolerances for corn, wheat, soybeans, cottonseed, potatoes, pome fruit, stone fruit, pomegranates, olives, grapes, tree nuts, and pistachios. The drinking
water assessment was based on partially refined, Tier 2 estimates generated by PRZM

EXAMS. However, the assessment assumed that 100% of the crops are treated with pyraflufen

- ethyl, and the assessment incorporated some default processing factors ( 6.5X for dried potatoes, 1.89X for peanut butter , 1.5X for corn syrup, and 1.92 for dried beef ),
both conservative assumption s

. Dietary estimates could be further refined through the use of percent crop treated data or monitoring data

.

VIII. Conclusions

Chronic dietary exposure analyses using DEEM

- FCIDTM indicate that chronic dietary exposure to the combined residues of pyraflufen

- ethyl and Metabolite E

- 1 from food and drinking water are not of concern to HED. The estimated chronic dietary exposure
utilized <1.0% of the cPAD for the general U.S. population, and all population subgroups. The cancer risk estimate is 2x10 - 6 

## and also not of concern to HED.

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

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Page 11 of 19 

## IX. List of Attachments

• Chronic Food Residue Input file.

• Cancer Food Residue Input file.

• Chronic Results file.

• Cancer Results File.

cc: Kristin Rury, Myron Ottley, Amelia Acierto.

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

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## Chronic Residue File:

Filename: C: \ Documents and Settings \ krury \ My Documents \ My Work Files \ Pyraflufen Ethyl \ Hops

and Peanuts \ Dietary Assessment \ Hops and Peanuts \ Hops and Peanuts CHRONIC revised dietary

burden.R08 Chemical: Pyraflufen ethyl RfD(Chronic): .2 mg/kg bw/day NOEL(Chronic): 20 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0332 Date created/last modified: 09

- 14

- 2012/15:25:39 Program ver. 3.16, 03

- 08

- d

Comment: no acute tox endpoint; chronic water 0.295 ppb

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0103296000 1C Potato, chips 0.010000 1.000 1.000 DER: 4

Full comment: DER: 45283015 & 45283016

010 3297000 1C Potato, dry (granules/ flakes) 0.010000 6.500 1.000 DER: 4

Full comment: DER: 45283015 & 45283016 0103297001 1C Potato, dry (granules/ flakes)

- b 0.010000 6.500 1.000 DER: 4

Full comment: DER: 45283015 & 45283016 0103298000 1C Potato, flour 0.010000 6.500 1.000 DER: 4

Full comment: DER: 45283015 & 45283016 0103298001 1C Potato, flour

- babyfood 0.010000 6.500 1.000 DER: 4

Full comment: DER: 45283015 & 45283016 0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.010000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000

0103 300001 1C Potato, tuber, w/o peel

- babyfood 0.010000 1.000 1.000 0600347000 6 Soybean, seed 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0600349000 6 Soybean, soy milk 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0600349001 6 Soybean, soy milk

- babyfood or in 0.005000 1.000 1.000 MRID 4

Full comment: MRID 456431 02 1/2 LOQ comb 0600350000 6 Soybean, oil 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0600350001 6 Soybean, oil

- babyfood 0.005000 1.000 1.000 MRID 4

Full comm ent: MRID 45643102 1/2 LOQ comb 0603348000 6C Soybean, flour 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0603348001 6C Soybean, flour

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 1100007000 11 Apple, fruit with peel 0.005000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.005000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.0 05000 1.000 1.000 1100009000 11 Apple, dried 0.005000 1.000 1.000 1100009001 11 Apple, dried

- babyfood 0.005000 1.000 1.000 1100010000 11 Apple, juice 0.005000 1.000 1.000

11 00010001 11 Apple, juice

- babyfood 0.005000 1.000 1.000 1100011000 11 Apple, sauce 0.005000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.005000 1.000 1.000 1100129000 11 Crabapple 0.005000 1.000 1.000 1100210000 11 Loquat 0.005000 1.000 1.000

1100266000 11 Pear 0.005000 1.000 1.000

1100266001 11 Pear

- babyfood 0 .005000 1.000 1.000 1100267000 11 Pear, dried 0.005000 1.000 1.000 1100268000 11 Pear, juice 0.005000 1.000 1.000 1100268001 11 Pear, juice

- babyfood 0.005000 1.000 1.000 1100310000 11 Quince 0.005000 1.000 1.000 1201090000 12A Cherry 0.005000 1.000 1.000 1201090001 12A Cherry

- babyfood 0.005000 1.000 1.000 1201091000 12A Cherry , juice 0.005000 1.000 1.000 1201091001 12A Cherry, juice

- babyfood 0.005000 1.000 1.000 1202012000 12B Apricot 0.005000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.005000 1.000 1.000

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 13 of 19 1202013000 12B Apricot, dried 0.005000 1.000 1.000 1202014000 12B Apricot, juice 0.005000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.005000 1.000 1.0 00

1202230000 12B Nectarine 0.005000 1.000 1.000

1202260000 12B Peach 0.005000 1.000 1.000

1202260001 12B Peach

- babyfood 0.005000 1.000 1.000

1202261000 12B Peac h, dried 0.005000 1.000 1.000 1202261001 12B Peach, dried

- babyfood 0.005000 1.000 1.000 1202262000 12B Peach, juice 0.005000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 0.005000 1.000 1.000

1203285000 12C Plum 0.005000 1.000 1.000

1203285001 12C Plum

- babyfood 0.005000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.005000 1.000 1 .000 1203286001 12C Plum, prune, fresh

- babyfood 0.005000 1.000 1.000 1203287000 12C Plum, prune, dried 0.005000 1.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.005000 1.000 1.000

1203288000 12C Pl um, prune, juice 0.005000 1.000 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.005000 1.000 1.000 1304175000 13D Grape 0.005000 1.000 1.000 1304176000 13D Grape, juice 0.005000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 0.005000 1.000 1.000 1304179000 13D Grape, wine and sherry 0.005000 1.000 1.000

1400003000 14 Almond 0.005000 1.000 1.000

1400003001 14 Almond

- babyfood 0.005000 1.000 1.000 1400004000 14 Almond, oil 0.005000 1.000 1.000 1400004001 14 Almond, oil

- babyfood 0.005000 1.000 1.000

1400059000 14 Brazil nut 0.005000 1.000 1.000

1400068000 14 Butternut 0.005000 1.000 1.000

1400081000 14 Cashew 0.005000 1.000 1.000

1400092000 14 Chestnut 0.005000 1.000 1.000

1400155000 14 Hazelnut 0.005000 1.000 1.000 1400156000 14 Hazelnut, oil 0.005000 1.000 1.000 1400185000 14 Hickory nut 0.005000 1.000 1.000

1400213000 14 Macadamia nut 0.005000 1.000 1.000

1400269000 14 Pecan 0.005000 1.000 1.000

1400282000 14 Pistachio 0.005000 1.000 1.000

1400391000 14 Walnut 0.005000 1.000 1.000 1500120000 15 Corn, field, flour 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb.
1500120001 15 Corn, field, flour

- babyf ood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500121000 15 Corn, field, meal 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb.
1500121001 15 Corn, field, meal

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500122000 15 Corn, field, bran 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb.

1500 123000 15 Corn, field, starch 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500123001 15 Corn, field, starch

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500124000 15 Corn, field, syrup 0.005000 1.500 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500124001 15 Corn, field, syrup

- babyfood 0.005000 1.500 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb.
1500125000 15 Corn, field, oil 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500125001 15 Corn, field, oil

- babyfood 0.005000 1.0 00 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500401000 15 Wheat, grain 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb. 1500401001 15 Wheat, grain

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.
1500402000 15 Wheat, flour 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.
1500402001 15 Wheat, flour

- babyfood 0.005000 1.000 1.000 MRID 4

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 14 of 19 Full comment: MRID 46587603 1/2 LOQ comb. 1500403000 15 Wheat, germ 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.

1500404000 15 Wheat, bran 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.
2003128000 20C Cottonseed, oil 0.020000 0.600 1.000 Proces

Full comment: Processing study MRID 45283014 2003128001 20C Cottonseed, oil

- babyfood 0.020000 0.600 1.000 Proces

Full comment: Processing study MRID45283014 3100044000 31 Beef, meat 0.001000 1.000 1.000 3100044001 31 Beef, meat

- baby food 0.001000 1.000 1.000 3100045000 31 Beef, meat, dried 0.001000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.001000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.001 000 1.000 1.000 3100047000 31 Beef, fat 0.001000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.001000 1.000 1.000 3200169000 32 Goat, meat 0.001000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.001000 1.000 1.000 3200171000 32 Goat, fat 0.001000 1.000 1.000 3300189000 33 Horse, meat 0.001000 1.000 1.000 3500339000 35 Sheep, me at 0.001000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.001000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.001000 1.000 1.000 3500341000 35 Sheep, fat 0.001000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.001000 1.000 1.000 3600222000 36 Milk, fat 0.001000 1.000 1.000 3600222001 36 Milk, fat

- baby food/infant formu 0.001000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.001000 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.001000 1.000 1.000 3600224000 36 Milk, water 0.001000 1.000 1.000 3600224001 36 Milk, w ater

- babyfood/infant form 0.001000 1.000 1.000 8601000000 86A Water, direct, all sources 0.000295 1.000 1.000 8602000000 86B Water, indirect, all sources 0.000295 1.000 1.000 9500177000 O Grape, leaves 0.005000 1.000 1.000 9500178000 O Grape, raisin 0.005000 1.000 1.000 9500188000 O Hop 0.010000 1.000 1.000

9500235000 O Olive 0.005000 1.000 1.00 0 9500236000 O Olive, oil 0.005000 1.000 1.000

9500263000 O Peanut 0.010000 1.000 1.000 9500264000 O Peanut, butter 0.010000 1.890 1.000

9500265000 O Peanu t, oil 0.010000 1.000 1.000 9500289000 O Pomegranate 0.005000 1.000 1.000



## Cancer Residue File:

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 15 of 19 Filename: C: \ Documents and Settings \ krury \ My Documents \ My Work Files \ Pyraflufen Ethyl \ Hops

and Peanuts \ Dietary Assessment \ Hops and Peanuts \ Hops Peanuts CANCER revised dietary

burden.R08 Chemical: Pyraflufen ethyl RfD(Chronic): .2 mg/kg bw/day NOEL(Chronic): 20 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0332 Date created/last modified: 09

- 14

- 2012/15:32:20 Program ver. 3.16, 03

- 08

- d Comment: no acute tox endpoint; cancer water 0.268 ppb

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0103296000 1C Potato, chips 0.010000 1.000 1.000 DER: 4

Full comment: DER: 45283015 & 45283016 0103297000 1C Potato, dry (granules/ flakes) 0.010000 6.500 1.000 DER: 4

Full comment: DER: 45283015 & 45283016 0103297001 1C Potato, dry (gr anules/ flakes)

- b 0.010000 6.500 1.000 DER: 4

Full comment: DER: 45283015 & 45283016 0103298000 1C Potato, flour 0.010000 6.500 1.000 DER: 4

Full comment: DER: 45283015 & 45283016

0103298001 1C Pot ato, flour

- babyfood 0.010000 6.500 1.000 DER: 4

Full comment: DER: 45283015 & 45283016 0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.010000 1. 000 1.000 0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.010000 1.000 1.000 0600347000 6 Soybean, seed 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0600349000 6 Soybean, soy milk 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0600349001 6 Soybean, soy milk

- babyfood or in 0.005000 1.000 1.00 0 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0600350000 6 Soybean, oil 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0600350001 6 Soybean, oil

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0603348000 6C Soybean, flour 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 0603348001 6C Soybe an, flour

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45643102 1/2 LOQ comb 1100007000 11 Apple, fruit with peel 0.005000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.005000 1. 000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.005000 1.000 1.000 1100009000 11 Apple, dried 0.005000 1.000 1.000 1100009001 11 Apple, dried

- babyfood 0.005000 1.000 1.000

1100010000 1 1 Apple, juice 0.005000 1.000 1.000 1100010001 11 Apple, juice

- babyfood 0.005000 1.000 1.000 1100011000 11 Apple, sauce 0.005000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.005000 1.000 1.000 1100129000 11 Crabapple 0.005000 1.000 1.000 1100210000 11 Loquat 0.005000 1.000 1.000

1100266000 11 Pear 0.005000 1.000 1.000

1100266001 11 Pear

- babyfood 0.005000 1.000 1.000 1100267000 11 Pear, dried 0.005000 1.000 1.000 1100268000 11 Pear, juice 0.005000 1.000 1.000

1100268001 11 Pear, juice

- babyfood 0.005000 1.000 1.000 1100310000 11 Quince 0.005000 1.000 1.000 1201090000 12A Cherry 0.005000 1.000 1.000 1201090001 12A Cherry

- babyfood 0.005000 1.000 1.000 1201091000 12A Cherry, juice 0.005000 1.000 1.000 1201091001 12A Cherry, juice

- babyfood 0.005000 1.000 1.000 1202012000 12B Apricot 0.005000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.005000 1.000 1.000 1202013000 12B Apricot, dried 0.005000 1.000 1.000

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 16 of 19 1202014000 12B Apricot, juice 0.005000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.005000 1.000 1.000

1202230000 12B Nectarine 0.005000 1.000 1.000

1202260000 12B Peach 0.005000 1.000 1.000

1202260001 12B Peach

- bab yfood 0.005000 1.000 1.000 1202261000 12B Peach, dried 0.005000 1.000 1.000 1202261001 12B Peach, dried

- babyfood 0.005000 1.000 1.000 1202262000 12B Peach, juice 0.005000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 0.005000 1.000 1.000

1203285000 12C Plum 0.005000 1.000 1.000

1203285001 12C Plum

- babyfood 0.005000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.005000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 0.005000 1.000 1.000 1203287000 12C Plum, prune, dried 0.005000 1.000 1.000 1203287001 12C Plum, p rune, dried

- babyfood 0.005000 1.000 1.000 1203288000 12C Plum, prune, juice 0.005000 1.000 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.005000 1.000 1.000 1304175000 13D Grape 0.005000 1.000 1.000 1304176000 13D Grape, juice 0.005000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 0.005000 1.000 1.000 1304179000 13D Grape, wine and sherry 0.005000 1.000 1.00 0

1400003000 14 Almond 0.005000 1.000 1.000

1400003001 14 Almond

- babyfood 0.005000 1.000 1.000 1400004000 14 Almond, oil 0.005000 1.000 1.000

1400004001 14 Almon d, oil

- babyfood 0.005000 1.000 1.000

1400059000 14 Brazil nut 0.005000 1.000 1.000

1400068000 14 Butternut 0.005000 1.000 1.000

1400081000 14 Cashew 0.005000 1.000 1.000

1400092000 14 Chestnut 0.005000 1.000 1.000

1400155000 14 Hazelnut 0.005000 1.000 1.000 1400156000 14 Hazelnut, oil 0.005000 1.000 1.000 1400185000 14 Hickory nut 0.005000 1.000 1.000

1400213000 14 Macadamia nut 0.005000 1.000 1.000

1400269000 14 Pecan 0.005000 1.000 1.000

1400282000 14 Pistachio 0.005000 1.000 1.000

1400391000 14 Walnut 0.005000 1.000 1.000 1500120000 15 Corn, field, flour 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500120001 15 Corn, field, flour

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500121000 15 Corn, field, meal 0.0050 00 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500121001 15 Corn, field, meal

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500122000 15 Corn, field, bran 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500123000 15 Corn, field, starch 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb.
1500123001 15 Corn, field, starch

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500124000 15 Corn, field, syrup 0.005000 1.500 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb.

150 0124001 15 Corn, field, syrup

- babyfood 0.005000 1.500 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb.
1500125000 15 Corn, field, oil 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500125001 15 Corn, field, oil

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 45666501 1/2 LOQ comb. 1500401000 15 Wheat, grain 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb. 1500401001 15 Wheat, grain

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.
1500402000 15 Wheat, flour 0.005000 1.0 00 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.
1500402001 15 Wheat, flour

- babyfood 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 17 of 19 1500403000 15 Wheat, germ 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.
1500404000 15 Wheat, bran 0.005000 1.000 1.000 MRID 4

Full comment: MRID 46587603 1/2 LOQ comb.
2003128000 20C Cottonseed, o il 0.020000 0.600 1.000 Proces

Full comment: Processing study MRID45283014 2003128001 20C Cottonseed, oil

- babyfood 0.020000 0.600 1.000 Proces

Full comment: Processing study MRID45283014

3100044 000 31 Beef, meat 0.001000 1.000 1.000 3100044001 31 Beef, meat

- babyfood 0.001000 1.000 1.000 3100045000 31 Beef, meat, dried 0.001000 1.920 1.000 3100046000 31 Beef, meat bypro ducts 0.001000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.001000 1.000 1.000 3100047000 31 Beef, fat 0.001000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.0010 00 1.000 1.000 3200169000 32 Goat, meat 0.001000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.001000 1.000 1.000 3200171000 32 Goat, fat 0.001000 1.000 1.000

33001 89000 33 Horse, meat 0.001000 1.000 1.000 3500339000 35 Sheep, meat 0.001000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.001000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.001000 1.000 1.000 3500341000 35 Sheep, fat 0.001000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.001000 1.000 1.000 3600222000 36 Milk, fat 0.001000 1.000 1.000 3600222001 36 Milk, fat

- baby food/infant formu 0.001000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.001000 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.001000 1.000 1.000 3600224000 36 Milk, water 0.001000 1.000 1.000 3600224001 36 Milk, water

- babyfood/infant form 0.001000 1.000 1.000
8601000000 86A Water, direct, all sources 0.000268 1.000 1.000 8602000000 86B Water, indirect, all sources 0.000268 1.000 1.000 9500177000 O Grape, leaves 0.005000 1.000 1.000 9500178000 O Grape, raisin 0.005000 1.000 1.000 9500188000 O Hop 0.010000 1.000 1.000

9500235000 O Olive 0.005000 1.000 1.000 9500236000 O Olive, oil 0.005000 1.000 1.000

9500263000 O Peanut 0.010000 1.000 1.000 9500264000 O Peanut, butter 0.010000 1.890 1.000 9500265000 O Peanut, oil 0.010000 1.000 1.000 9500289000 O Pomegranate 0.005000 1.000 1.00 0



## Chronic Results:

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for PYRAFLUFEN ETHYL NHANES 2003

- 2008 2

- day

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 18 of 19 Residue file name: C: \ Documents and Settings \ krury \ My Documents \ My Work Files \ Pyraflufen Ethyl \ Hops and Peanuts \ Dietary Assessment \ Hops and Peanuts \ Hops and Peanuts CHRONIC revised dietary burden.R08 Adjustment factor #2 NOT used. Analysis Dat e 09

- 14

- 2012/15:34:46 Residue file dated: 09

- 14

- 2012/15:34:08 Reference dose (RfD, Chronic) = .2 mg/kg bw/day COMMENT 1: no acute tox endpoint; chronic water 0.295 ppb

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

------------- ---------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ----------------
T otal US Population 0.000053 0.0% Hispanic 0.000058 0.0%

Non

- Hisp

- White 0.000052 0.0%

Non

- Hisp

- Black 0.000051 0.0%

Non

- Hisp

- Other 0.000055 0.0% Nursing Infants 0.000051 0.0%

Non

- Nursing Infants 0.000132 0.1%

Female 13+ PREG 0.000045 0.0%

Children 1

- 6 0.000159 0.1%

Children 7

- 12 0.000079 0.0%

Male 13

- 19 0.000051 0.0%

Female 13

- 19/NP 0.000044 0.0%

Male 20+ 0.000039 0.0% Female 20+/NP 0.000036 0.0%

Seniors 55+ 0.000035 0.0%

All Infants 0.000107 0.1%

Female 13

- 50 0.000039 0.0%

Children 1

- 2 0.000199 0.1%

Children 3

- 5 0.000143 0.1%

Children 6

- 12 0.000085 0.0%

Youth 13

- 19 0.000048 0.0%

Adults 20

- 49 0.000040 0.0%

Adults 50

- 99 0.000035 0.0%

Female 13

- 49 0.000039 0.0%

---------------- ---------------------------------------------------------------



## C ancer Results:

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for PYRAFLUFEN ETHYL NHANES 2003

- 2008 2

- day

### Pyraflufen

- ethyl Dietary Exposure and Risk Assessment DP Number: 397422

PC Code: 030090

______________________________________________________________________________________

Page 19 of 19 Residue file name: C: \ Documents and Settings \ krury \ My Documents \ My Work Files \ Pyraflufen Ethyl \ Hops and Peanuts \ Dietary Assessment \ Hops and Peanuts \ Hops Peanuts CANCER revised dietary burden.R08 Adjust ment factor #2 NOT used. Analysis Date 09

- 14

- 2012/15:35:46 Residue file dated: 09

- 14

- 2012/15:32:20
Q* = 0.0332 COMMENT 1: no acute tox endpoint; cancer water 0.268 ppb

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Lifetime risk Subgroup body wt/day (Q*= .0332)

---------------------------------- ---- ------------- -------------- Total US Population 0.000052 1.74E

- 06 Hispanic 0.000058 1.92E

- 06

Non

- Hisp

- White 0.000052 1.71E

- 06

Non

- Hi sp

- Black 0.000050 1.67E

- 06

Non

- Hisp

- Other 0.000055 1.82E

- 06 Nursing Infants 0.000051 1.68E

- 06

Non

- Nursing Infants 0.000130 4.33E

- 06

Female 13+ PREG 0.000045 1.48E

- 06

Children 1

- 6 0.000158 5.26E

- 06

Children 7

- 12 0.000078 2.60E

- 06

Male 13

- 19 0.000051 1.69E

- 06

Female 13

- 19/NP 0.000044 1.46E

- 06

Male 20+ 0.000039 1.29E

- 06 Female 20+/NP 0.000035 1.17E

- 06

Seni ors 55+ 0.000034 1.14E

- 06

All Infants 0.000106 3.51E

- 06

Female 13

- 50 0.000038 1.27E

- 06

Children 1

- 2 0.0001 98 6.57E

- 06

Children 3

- 5 0.000142 4.72E

- 06

Children 6

- 12 0.000085 2.81E

- 06

Youth 13

- 19 0.000047 1.57E

- 06

Adults 20

- 49 0.000039 1.30E

- 06

Adults 50

- 99 0.000034 1.14E

- 06

Female 13

- 49 0.000038 1.27E

- 06

-------------------------------------------------------------------------------