Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174

1. Company Name and Address N/A - Pyridaben Chemical # and Name: 129105 Pyridaben 17-Nov-2011 GENERIC ID # GDCI-129105-855 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Environmental Fate Data Requirements (Conventional Chemical)

Nontarget Plant Protection Data Requirements (Conventional Chemical) 835.4100 835.4300 835.4400 835.6100 835.6200

850.4100 850.4150 850.4400 Aerobic soil metabolism

Aerobic aquatic metabolism Anaerobic aquatic metabolism Terrestrial field dissipation Aquatic field dissipation

Terrestrial Plant Toxicity (Seedling Emergence) Terrestrial plant toxicity, Tier 1 (vegetative vigor) Aquatic plant toxicity test using Lemna spp. Tiers I and II N/A - Pyridaben Chemical # and Name: 129105 Pyridaben 17-Nov-2011 GENERIC ID # GDCI-129105-855

C,H,A C,H,A C,H,A C,H,A C,H,A

C,H,A C,H,A C,H,A TGAI or PAIRA TGAI or PAIRA TGAI or PAIRA TEP TEP

TEP TEP TEP or TGAI 24 24 24 24 24

12 12 12 1 of Page

(5) (6) (4) (17) (16)

(3) (2) (14) N N N N N

N N N 3OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Nontarget Plant Protection Data Requirements (Conventional Chemical)
Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 850.5400

850.1075 850.1350 850.1400 850.1710 850.1735 850.1850 850.3040 Algal toxicity, Tiers 1 and II

Fish acute toxicity test, freshwater and marine Mysid chronic toxicity test Fish early-life stage toxicity test Oyster BCF Whole sediment: acute freshwater invertebrates Aquatic food chain transfer Field testing for pollinators N/A - Pyridaben Chemical # and Name: 129105 Pyridaben 17-Nov-2011 GENERIC ID # GDCI-129105-855

C,H,A

C,H,A C,H,A C,H,A C,H,A C,H,A C,H,A C,H,A TEP or TGAI

TGAI, TEP TGAI TGAI TGAI, PAI, Degr TGAI TGAI, PAI, Degr TEP 12

12 12 12 12 12 12 24 2 of Page

(15)

(18)
(11) (8) (11, 13) (10, 12) N

N N N N N N N 3Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Toxicology Data Requirements (Conventional Chemical) 870.7800

SS-1066 SS-1069 SS850.1000 Immunotoxicity

Chronic Sediment - Hyalella Azteca Chronic Sediment - Chironomus dilutus Chronic Estuarine/Marine Sediment Testing N/A - Pyridaben Chemical # and Name: 129105 Pyridaben 17-Nov-2011 GENERIC ID # GDCI-129105-855

C,H,A

C,H,A C,H,A C,H,A TGAI 12

24 24 24 3 of Page

(1)

(9) (7) (7) N

N N N 3

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Pyridaben GDCI-129105-855

1 2 3 4 5 6 7 8 9 10

11 12 13 14

15 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Two immunotoxicity studies are required to address both the rat and mouse. These studies must be conducted at the highest single application rate for pyridaben (1.0 lbs a.i./A on ornamentals) and with a typical end use product containing pyridaben. Tier II data should be submitted for that species. These studies must be conducted at the highest single application rate for pyridaben (1.0 lbs a.i./A on ornamentals) and with a typical end use product containing pyridaben. Tier II data should be submitted for that species. The Agency is requiring an anaerobic aquatic metabolism study conducted at a pH that is typical of an aquatic environment where pyridaben is applied. The Agency is requiring an aerobic soil metabolism study conducted on three additional relevant soils of different organic carbon content, pH, clay content, and microbial biomass. The Agency is requiring an aerobic aquatic metabolism study conducted at a pH that is typical of an aquatic environment where pyridaben is applied. Testing is required if the soil partition coefficient (Kd) is equal to or greater than 50 and the pesticide is persistent (e.g., half-life in sediment is equal to or less than 10 days) in either the aerobic soil or aquatic metabolism studies. Registrants must submit a study protocol for review by Agency prior to initiation of study. Testing is required if the soil partition coefficient (Kd) is equal to or greater than 50 and the pesticide is persistent (e.g., half-life in sediment is equal to or less than 10 days) in either the aerobic soil or aquatic metabolism studies. Registrants must submit a study protocol for review by Agency prior to initiation of study. Testing is required if the soil partition coefficient (Kd) is equal to or greater than 50 and the pesticide is persistent (e.g., half-life in sediment is equal to or less than 10 days) in either the aerobic soil or aquatic metabolism studies. Registrants must submit a study protocol for review by Agency prior to initiation of study. Required if any of the following conditions are met: (i) data from other sources (Experimental Use Permit program, university research, registrant submittals, etc.) indicate potential adverse effects on colonies, especially effects other than acute mortality (reproductive, behavioral, etc.); (ii) data from residual toxicity studies indicate extended residual toxicity; (iii) data derived from studies with arthropods other than bees that indicate potential chronic, reproductive, or behavioral effects. Required based on the results of fish or aquatic nontarget organisms accumulation studies (guidelines 850.1730 and 850.1950). Pyridaben registrants must submit a study protocol for review by the Agency prior to initiation of the field testing. Pyridaben registrants must submit a study protocol for review by the Agency prior to initiation of the aquatic food chain transfer study. In order to fulfill the guideline requirement for aquatic vascular plants, additional Tier I data must be submitted for a vascular aquatic plant (i.e. duckweed) exposed to pyridaben at a concentration up to the solubility limit of pyridaben (12 ug ai/L0 or test the formulated product to insure it doesn't enhance solubility and/or effects. If the Tier I data result in >50% effects to the test species, Tier II data should be submitted for that species. In order to fulfill the guideline requirement for algae, additional Tier I data must be submitted for 4 species of algae exposed to pyridaben at a concentration up to the solubility limit of pyridaben (12 ug ai/L) or test the formulated product to insure it doesn't enhance solubility and/or effects. If the Tier I data result in >50% effects to any test species, Tier II data should be submitted for Case # and Name: DCI Number: 1 Page: of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop C - Terrestrial nonfood crop H - Greenhouse food crop 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Pyridaben GDCI-129105-855

16 17 18 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

that species. Environmental Chemistry Analytical Method and Independent Laboratory Validation for Residues in Water (see 40 CFR section 158.1300 note 7) Environmental Chemistry Analytical Method and Independent Laboratory Validation for Residues in Soil (see 40 CFR sectoin 158.1300 note 7) Data are required on estuarine species if the product is: (i) intended for direct application to the estuarine or marine environment; (ii) expected to enter this environment in significant concentrations because of its expected use or mobility patterns, and (iii) if the acute LC50 or EC50 < 1 mg/l; or (iv) if the estimated environmental concentration in water is equal to or greater than 0.01 of the acute EC50 or LC50 and any of the following conditions exist: (a) studies of other organisms indicate the reproductive physiology of fish and/or invertebrates may be affected; (b) physicochemical properties indicate bioaccumulation of the pesticide; (c) the pesticide is persistent in water (e.g., half-life in water greater than 4 days). Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE N/A - Pyridaben Case # and Name: 1 Page: of 1

33906 NISSAN CHEMICAL INDUSTRIES LTD Co. Nr. Company Name Agent For Company LEWIS & HARRISON, LLC 122 C STREET, N.W., SUITE 505 Address City ZIP WASHINGTON 20001 OMB Approval 2070-0174

State DC DCI Number: GDCI-129105-855

# LINKS TO FORMS: The pesticide registration forms that are listed below can be found at: http://www.epa.gov/opprd001/forms/ Link to C onfidential Statement of Formula and Instructions (Form # 8570 -4 

# ) http://www.epa.gov/opprd001/forms/8570 - 4.pdf C ertification of Attempt to Enter Into an Agreement With Registrants for Development of Data (Form # 8570 - 32 

# ) http://www.epa.gov/opprd001/forms/8570 - 32.pdf
C ertification With Respect to Citation of Data (Form # 8570 - 34 

# ) http://www.epa.gov/opprd001/forms/8570 - 34.pdf