| Attachment    I | Final Scope of Work, including      the description of Services to be provided and    timeline |
|-----------------|------------------------------------------------------------------------------------------------|

| Attachment    II | Budget and Payment Terms for the      Final Scope of Work |
|------------------|-----------------------------------------------------------|

|      |   |   |
|-----------|--------|--------|
| Signature |   | Date   |
|      |   |   |
|      |   |   |
| Name      |   |   |
|      |   |   |
|      |   |   |
| Title     |   |   |

| /s/ David G.P. Allan |   | [ILLEGIBLE] |
|----------------------|--------|-------------|
| Signature            |   | Date        |
|                 |   |        |
| David G.P. Allan     |   |        |
| Name                 |   |        |
|                 |   |        |
| CHAIR & CEO      |   |        |
| Title                |   |        |

----

| · | Project      Management (USA)  | · | Medical      Monitoring (USA)                           |
|--------|--------------------------------|--------|---------------------------------------------------------|
| · | Clinical      Monitoring (USA) | · | Pharmacovigilance      (inc OC AERS set-up/maintenance) |
| · | Data      Management           | · | Medical      Writing                                    |
| · | Biostatistics                  | · | Clinical      Trial Material Distribution(USA)          |

| PARAMETERS:                                                                                    |   |                                         |   |
|-----------------------------------------------------------------------------------------------------|--------|----------------------------------------------|--------|
| Number      of Completed Patients:                                                                  |   | 44                                           |   |
|                                                                                                |   | (30      USA patients)                       |   |
| Number      of Investigative Sites:                                                                 |   | 13                                           |   |
|                                                                                                |   | ( 8      USA)                                |   |
| Estimated      Number of Total CRF Pages Per Patient:                                               |   | 150                                          |   |
| Estimated      Number of Unique CRF Pages Per Patient:                                              |   | 25                                           |   |
| Total      Number of CRF Pages:                                                                     |   | 6,600                                        |   |
| Estimated      Number of Queries:                                                                   |   | 1,320                                        |   |
| Total      Number of Serious Adverse Events:                                                        |   | 44                                           |   |
| Total      Number of Face-to-Face Project Meetings(alternating      between AAIPharma and YMB USA): |   | 4      with PM2      with Team               |   |
| Total      Number of Teleconferences:                                                               |   | 47      with PM/RA (24 inc. Team)            |   |
| USA      SITES                                                                                      |   |                                         |   |
| Total      Number of Qualification Site Assessment (QSA)                                            |   |                                         |   |
| Visits:                                                                                             |   | To      be performed during Initiation Visit |   |
|                                                                                                |   |                                         |   |
| Total      Number of Initiation Visits:                                                             |   | 8                                            |   |
|                                                                                                |   |                                         |   |
| Total      Number of Interim Visits:                                                                |   | Average      5 two-day Visits per site       |   |
|                                                                                                |   |                                         |   |
| Total      Number of Closeout Visits:                                                               |   | 8                                            |   |
|                                                                                                |   |                                         |   |
| Total      Number of Tables:                                                                        |   | 30                                           |   |
| Total      Number of Listings:                                                                      |   | 25                                           |   |
| Total      Number of Figures:                                                                       |   | 5                                            |   |
| Total      Number of Outputs:                                                                       |   | 5                                            |   |

| AAIPharma/YMB      USA Work Order #1 R3 | Page      1 of 5 |
|-----------------------------------------|------------------|
| Attachment      I                       |             |

----

| TIME      LINE                            |   |                                                  |   |
|-------------------------------------------|--------|-------------------------------------------------------|--------|
| Project      Award (LOI executed):        |   | August      27, 2007                                  |   |
| Study      Start-up:                      |   | 3      months                                         |   |
| Patient      Enrollment Duration:         |   | 14      months                                        |   |
| Patient      Treatment Duration:          |   | Up      to 4.5 months (18 weeks)                      |   |
| Follow-up      Duration:                  |   | Up      to 4 months                                   |   |
| Database      Lock:                       |   | 1      month after last CRF in-house                  |   |
| Draft      Tables, Listings and Figures1: |   | 3      Weeks from Database Lock                       |   |
| Final      Tables, Listings and Figures1: |   | 2      Weeks from Receipt of YMB USA’s Comments |   |
| Draft      Report1:                       |   | 4      Weeks from Final Tables, Listings and Figures  |   |
| Final      Report1:                       |   | 2      Weeks from Receipt of YMB USA’s Comments |   |
| TOTAL      PROJECT DURATION               |   | 29      months                                        |   |

| Service                                                    |   | YMB USAResponsibility |   | AAIPharmaResponsibility                |   |
|------------------------------------------------------------|--------|----------------------------|--------|----------------------------------------|--------|
| Kickoff      Meeting                                       |   | ü                     |   | ü                                 |   |
| Prepare      Project Operational Plan (POP)                |   |                       |   | ü                                 |   |
| CRF      Design                                            |   |                       |   | ü                                 |   |
| CRF      Printing and Shipping                             |   |                       |   | ü                                 |   |
| Develop      Model Informed Consent Form                   |   |                       |   | ü                                 |   |
| Investigator      Selection                                |   | ü                     |   |                                   |   |
| Conduct      Qualifying Site Assessment Visits (USA Sites) |   |                       |   | Performed      atInitiation      Visit |   |
| Collect/Review      Regulatory Documents (USA Sites)       |   |                       |   | ü                                 |   |

| AAIPharma/YMB      USA Work Order #1 R3 | Page      2 of 5 |
|-----------------------------------------|------------------|
| Attachment      I                       |             |

----

| Service                                                                                                          |   | YMB USAResponsibility |   | AAIPharmaResponsibility |   |
|------------------------------------------------------------------------------------------------------------------|--------|----------------------------|--------|-------------------------|--------|
| Maintain      Trial Master File (USA Sites)                                                                      |   |                       |   | ü                  |   |
| File      Regulatory Documents with FDA                                                                          |   | ü                     |   |                    |   |
| Coordinate      Investigational Product Packaging/Shipping                                                       |   | ü                     |   | US      Sites           |   |
| ·      Client      will provide ready-to distribute clinical supplies         |   |                       |   |                    |   |
| ·      storage      at 2-8C                                                   |   |                       |   |                    |   |
| ·      Distribution      performed at 2-8C w/ temperature monitoring required |   |                       |   |                    |   |
| ·      Drug      return activities and destruction not required               |   |                       |   |                    |   |
| Assist      sites with IRB requirements                                                                          |   |                       |   | ü                  |   |
| Negotiate      Site Agreements                                                                                   |   | ü                     |   |                    |   |
| Execute      Site Agreements                                                                                     |   | ü                     |   |                    |   |
| Plan      and Coordinate Investigators’ Meeting                                                            |   | ü                     |   |                    |   |
| Attend      Investigators’ Meeting                                                                         |   | ü                     |   | ü                  |   |
|                                                                                                             |   |                       |   | 5      attendees        |   |
| Attend      Training Meeting                                                                                     |   | ü                     |   | ü                  |   |
| Conduct      Initiation Visits with Medical Monitor                                                              |   |                       |   | US      Sites           |   |
| Develop      Monitor Guidelines and Source Document Verification Plan      (SDVP)                                |   |                       |   | ü                  |   |
| Database      Design                                                                                             |   |                       |   | ü                  |   |
| Data      Management Operational Plan (DMOP)                                                                     |   |                       |   | ü                  |   |
| Generate      Statistical Analysis Plan                                                                          |   |                       |   | ü                  |   |

| Service                                            |   | YMB USAResponsibility |   | AAIPharmaResponsibility |   |
|----------------------------------------------------|--------|-----------------------|--------|-------------------------|--------|
| Provide      Interim Monitoring Visits (USA Sites) |   |                  |   | ü                  |   |
| Provide      Ongoing Site Management Services (USA |   |                  |   | ü                  |   |
| Sites)                                             |   |                  |   |                    |   |
| Administer      Payments of Investigator Grants    |   | ü                |   |                    |   |
| Provide      Status Reports to YMB USA             |   | ü                |   |                    |   |
| Provide      Medical Management (USA)              |   |                  |   | ü                  |   |
| Set-up      and Maintain Oracle AERS Database      |   |                  |   | ü                  |   |
| Provide      SAE Management                        |   |                  |   | ü                  |   |
| Preparation      of SAE narratives                 |   |                  |   | ü                  |   |

| AAIPharma/YMB      USA Work Order #1 R3Attachment      I | Page      3 of 5 |
|----------------------------------------------------------|------------------|

----

| Service                                            |   | YMB USAResponsibility |   | AAIPharmaResponsibility |   |
|----------------------------------------------------|--------|----------------------------|--------|-------------------------|--------|
| Filing      of SAE Reports with the FDA            |   | ü                     |   |                    |   |
| Participate      in Project Team Meetings          |   | ü                     |   | ü                  |   |
| Participate      in Teleconferences                |   | ü                     |   | ü                  |   |
| Provide      Quality Assurance Site Audits         |   |                       |   | ü                  |   |
| CRF      and Query Scanning, Tracking, and Storage |   |                       |   | ü                  |   |
| Data      Entry                                    |   |                       |   | ü                  |   |
| Data      Verification                             |   |                       |   | ü                  |   |
| Integration      of External Electronic Data       |   |                       |   | ü                  |   |
| Data      Validation                               |   |                       |   | ü                  |   |
| Data      Coding                                   |   |                       |   | ü                  |   |
| SAE      Report Reconciliation against CRF Data    |   |                       |   | ü                  |   |
| Database      Quality Control Audit                |   |                       |   | ü                  |   |
| Provide      Clean, Locked Database to YMB USA     |   |                       |   | ü                  |   |
| Quality      Assurance Site Audits                 |   |                       |   | ü                  |   |
|                                               |   |                       |   | Optional                |   |
| Advance      Planning for Study Report             |   | ü                     |   | ü                  |   |

| AAIPharma/YMB      USA Work Order #1 R3 | Page      4 of 5 |
|-----------------------------------------|------------------|
| Attachment      I                       |             |

----

| Service                                                 |   | YMB USAResponsibility |   | AAIPharmaResponsibility |   |
|---------------------------------------------------------|--------|----------------------------|--------|-------------------------|--------|
| Conduct      Study Closeout Visits (USA Sites)          |   |                       |   | ü                  |   |
| Generate      Statistical Tables, Listings, and Figures |   |                       |   | ü                  |   |
| Attend      Results Review Meeting                      |   | ü                     |   | ü                  |   |
| Generate      Draft Clinical Study Report (CSR)         |   |                       |   | ü                  |   |
| Comment      on Draft CSR                               |   | ü                     |   |                    |   |
| Finalize      Clinical Study Report                     |   |                       |   | ü                  |   |
| Prepare      and Transfer SAS Code                      |   |                       |   | ü                  |   |
| Study      Closeout Meeting                             |   | ü                     |   | ü                  |   |

| AAIPharma/YMB      USA Work Order #1 R3Attachment      I | Page      5 of 5 |
|----------------------------------------------------------|------------------|

----

----

|   | 44    |   | Total      Enrolled Patients |
|--------|-------|--------|------------------------------|
|   | 30    |   | Total      US Patients       |
|   | 8     |   | US      Sites                |
|   | 6,600 |   | Total      CRF Pages         |
|   | 29    |   | Months      Study Duration   |

|                                                               |   | ESTIMATED BUDGET |   |
|--------------------------------------------------------------------|--------|-----------------------|--------|
| PROJECT      MANAGEMENT                                            |   |                  |   | 189,441 |   |
| PROJECT      COORDINATION (29 months)                              |   | 149,497               |   |   |   |
| PROJECT      MEETINGS AND CONFERENCE CALLS                         |   | 39,944                |   |   |   |
|                                                               |   |                  |   |   |   |
| STUDY      SETUP                                                   |   |                  |   | 63,552 |   |
| REGULATORY      DOCUMENT COLLECTION AND PROCESSING                 |   | 14,692                |   |   |   |
| PROJECT      TEAM TRAINING AND KICK-OFF MEETING                    |   | 7,303                 |   |   |   |
| INVESTIGATORS      MEETINGS (US Sites Face-to-Face)                |   |                  |   |   |   |
| ATTENDANCE      & PARTICIPATION                                |   | 21,136                |   |   |   |
| COORDINATION      FEE                                              |   | 0                     |   |   |   |
| CRF      DESIGNS AND INSTRUCTIONS                                  |   | 20,422                |   |   |   |
| ADMINISTRATION      & PAYMENT OF LABORATORY                    |   | 0                     |   |   |   |
| ADMINISTRATION      OF INVESTIGATOR GRANTS                         |   | 0                     |   |   |   |
|                                                               |   |                  |   |   |   |
| CLINCAL/MEDICAL      AFFAIRS                                       |   |                  |   | 603,600 |   |
| QSA/INITIATION      VISITS (8)                                     |   | 21,093                |   |   |   |
| MEDICAL      MONITOR TO ATTEND QSA/INITIATION VISITS               |   | 34,367                |   |   |   |
| INTERIM      MONITORING VISITS (Average 5 two-day visits per site) |   | 135,965               |   |   |   |
| CLOSEOUT      VISITS (8)                                           |   | 15,916                |   |   |   |
| STATUS      REPORTS                                                |   | 8,893                 |   |   |   |
| MEDICAL      MANAGEMENT                                            |   | 27,123                |   |   |   |
| SAE      MANAGEMENT SET-UP AND MAINTENANCE (Oracle AERS)           |   | 13,597                |   |   |   |
| SAE      MANAGEMENT                                                |   | 76,553                |   |   |   |
| SAE      NARRATIVES (Includes MedWatch/CIOMS reports)              |   | 17,248                |   |   |   |
| SITE      MANAGEMENT                                               |   | 70,646                |   |   |   |
| CLINICAL      REGULATORY SITE SUPPORT                              |   | 56,061                |   |   |   |
| CLINICAL      PROJECT COORDINATION                                 |   | 126,138               |   |   |   |
|                                                               |   |                  |   |   |   |
| DATA      MANAGEMENT & CLINICAL DATA SYSTEMS                   |   |                  |   | 281,714 |   |
| DATA      MANAGEMENT OPERATIONAL PLAN                              |   | 16,260                |   |   |   |
| DATABASE      DESIGN, PROGRAMMING AND TESTING                      |   | 55,686                |   |   |   |
| DATA      ENTRY AND VERIFICATION                                   |   | 34,555                |   |   |   |
| DICTIONARY      CODING                                             |   | 8,141                 |   |   |   |
| CRF      AND QUERY TRACKING & INVENTORY VIA SCANNING           |   | 7,443                 |   |   |   |
| DATA      VALIDATION INCLUDING QUERY GENERATION & RESOLUTION   |   | 50,326                |   |   |   |
| MEDICAL      REVIEW OF CRFs                                        |   | 20,674                |   |   |   |
| DATABASE      QUALITY CONTROL AUDIT                                |   | 10,526                |   |   |   |
| EXTERNAL      DATA INTEGRATION                                     |   | 1,300                 |   |   |   |
| DATA      MANAGEMENT PROJECT COORDINATION                          |   | 57,619                |   |   |   |
| ADMINISTRATIVE                                                     |   | 12,570                |   |   |   |
|                                                               |   |                  |   |   |   |
| BIOSTATISTICAL/REPORT      PREPARATION SERVICES                    |   |                  |   | 143,401 |   |
| STATISTICAL      ANALYSIS PLAN                                     |   | 13,069                |   |   |   |
| STATISTICAL      TABLES, LISTINGS & PROGRAMMING                |   | 52,062                |   |   |   |
| ANALYSIS      PRODUCTION                                           |   | 19,497                |   |   |   |
| INTEGRATED      CLINICAL/STATISTICAL REPORT                        |   | 43,780                |   |   |   |
| RESULTS      REVIEW MEETING                                        |   | 3,157                 |   |   |   |
| BIOSTATISTICAL/REPORT      PROJECT COORDINATION                    |   | 11,835                |   |   |   |
|                                                               |   |                  |   |   |   |
| TOTAL      ESTIMATED BUDGET                                        |   | 1,281,709             |   |   |   |
|                                                               |   |                  |   |   |   |
| ADDITIONAL      SERVICES                                           |   |                  |   |   |   |
| CLINICAL      TRIAL MATERIAL DISTRIBUTION TO US SITES              |   | 14,900                |   |   |   |
|                                                               |   |                  |   |   |   |
| TOTAL      ESTIMATED BUDGET EXCLUSIVE OF PASS THROUGH EXPENSES     |   | 1,296,609             |   |   |   |
|                                                               |   |                  |   |   |   |
| ESTIMATED      PASS THROUGH EXPENSES                               |   |                  |   | 66,850 |   |
| INVESTIGATOR      MEETING (incidentals @$100/attendee)             |   | 500                   |   |   |   |
| MONITOR      TRAVEL                                                |   | 46,000                |   |   |   |
| MEDICAL      MONITOR TRAVEL (8 VISITs)                             |   | 6,000                 |   |   |   |
| CRF      PRINTING AND SHIPPING                                     |   | 10,600                |   |   |   |
| PROJECT      MEETING EXPENSES                                      |   | 3,750                 |   |   |   |
|                                                               |   |                  |   |   |   |
| TOTAL      ESTIMATED BUDGET                                        |   | 1,363,459             |   |   |   |
|                                                               |   |                  |   |   |   |
| OPTIONAL      COSTS                                                |   |                  |   |   |   |
| CLINICAL      INTERIM MONITORING                                   |   |                  |   |   |   |
| ADDITIONAL      VISIT PER PATIENT (From 1 to 2 Visits per Patient) |   | 103,746               |   |   |   |
| SITE      VISIT TRAVEL                                             |   | 30,000                |   |   |   |
| QUALITY      ASSURANCE                                             |   |                  |   |   |   |
| INVESTIGATOR      SITE VISITS                                      |   | 10,149                |   |   |   |
| SITE      VISIT TRAVEL                                             |   | 1,000                 |   |   |   |

----

|                                                                                                  |   | First Budget |      |
|-------------------------------------------------------------------------------------------------------|--------|-------------------|-----------|
| Direct Costs:                                                                                    |   | USD               |      |
|                                                                                                  |   |              |      |
| Execution      of WorkOrder                                                                      |   | $                 | 129,661   |   |
| Milestones:                                                                                           |   |              |      |   |
| Monthly      Maintenance Fee (Project Management, Site Management, PVG, QA and Medical      Overview) |   |              |      |   |
| $13,083.20/month      for 29 months (Sept-07-Jan-07)                                        |   | $                 | 379,413   |   |
| Clinical:                                                                                             |   |              |      |   |
| Completion      of Base Documents                                                                     |   | $                 | 26,381    |   |
| First      Site Initiated                                                                             |   | $                 | 31,930    |   |
| 100%      Sites Initiated                                                                             |   | $                 | 95,789    |   |
| First      Patient Enrolled                                                                           |   | $                 | 60,835    |   |
| 20%      Monitoring Visits Completed                                                                  |   | $                 | 60,835    |   |
| 40%      Monitoring Visits Completed                                                                  |   | $                 | 60,835    |   |
| 60%      Monitoring Visits Completed                                                                  |   | $                 | 60,835    |   |
| 80%      Monitoring Visits Completed                                                                  |   | $                 | 60,835    |   |
| 100%      Monitoring Visits Completed                                                                 |   | $                 | 60,835    |   |
| All      Sites Closed-out                                                                             |   | $                 | 37,028    |   |
| Database      Set-Up                                                                                  |   | $                 | 44,573    |   |
| 50%      CRFs Completed                                                                               |   | $                 | 44,573    |   |
| 100%      CRFs Completed                                                                              |   | $                 | 44,573    |   |
| Database      Lock                                                                                    |   | $                 | 44,573    |   |
| Clinical      Study Report                                                                            |   | $                 | 53,108    |   |
| Total      Direct Costs                                                                               |   | $                 | 1,296,609 |   |

AAIPharma/YMB USA Work Order #1 R2

----