Exhibit 10.8



Boston Life Sciences License Amendment January 2004 HU 1194



This Amendment to the License Agreement (this Amendment) effective the last day signed below of 2004, is entered into by and between Boston
Life Sciences, Inc, a corporation organized and existing under the laws of Massachusetts having its principal offices at 20 Newbury St., 8th Floor, Boston, MA 02116, (hereinafter, LICENSEE) and The President and Fellows of Harvard
College, a charitable corporation of Massachusetts, having an office at Office of Technology Licensing and Industry Sponsored Research, Harvard Medical School, Gordon Hall of Medicine, Room 414, 25 Shattuck Street, Boston, MA 0211 (hereinafter
HARVARD).



WITNESSETH:



WHEREAS, a License Agreement (the License Agreement) was
entered into by and between LICENSEE and HARVARD with an effective date of October 15, 1996;



WHEREAS, LICENSEE desires to more fully focus its research and development efforts on two diseases;



WHEREAS, the parties hereto have determined that it is in their
respective best interests to amend Article 1 (DEFINITIONS) of the License Agreement to amend the definition of paragraph 1.3, (FIELD), and to amend Article VII (FOREIGN AND DOMESTIC PATENT FILING AND
MAINTENANCE) and Article VIII (INFRINGEMENT) of the License Agreement to more clearly delineate the rights and responsibilities of the parties hereto;



NOW, THEREFORE, the parties hereto agree as follows:



| | 1. | Amendment to the License Agreement.
| | -- | -----------------------------------



| | (a) | Paragraph 1.3 is hereby amended to read:
| | --- | ----------------------------------------



FIELD shall mean the diagnosis and/or treatment of (i) Attention Deficit Hyperactivity Disorder and (ii) Parkinsons Disease



| | (b) | Article VII is hereby amended to read:
| | --- | --------------------------------------



PATENT FILING, PROSECUTION AND MAINTENANCE



7.1 HARVARD shall own (jointly with Organix or other assignees as applicable), file, prosecute and maintain all U.S. and foreign patent applications and
patents included within the PATENT RIGHTS. LICENSEE shall be included in all prosecution-related correspondence with outside patent counsel, shall cooperate with HARVARD in the prosecution, filing and maintenance of the PATENT RIGHTS, and shall be
promptly copied on all documents received from or sent to all patent offices involved in examination, interference proceedings, oppositions and other matters related to the



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PATENT RIGHTS. HARVARD shall consult LICENSEE on each step of the prosecution process regarding exclusively licensed PATENT RIGHTS and HARVARD shall
incorporate LICENSEEs comments where reasonably practicable, but final decision making authority shall vest in HARVARD.



7.2 Upon execution of this Agreement, LICENSEE shall reimburse HARVARD for past and presently payable patent costs for the preparation, filing,
prosecution and maintenance of PATENT RIGHTS. HARVARD shall provide to LICENSEE an itemized invoice of all fees and costs associated with U.S. and foreign patent prosecution, U.S. and foreign patent annuities, and all costs associated with any
patent interference proceedings related to the PATENT RIGHTS (COSTS) whether such fees and/or costs were incurred before or after the date of this Agreement. LICENSEE shall have the opportunity to review said invoices, and shall have the
opportunity to discuss questionable billings incurred after the EFFECTIVE DATE either with HARVARD before HARVARD pays the invoiced billings, or directly with HARVARDs patent counsel, as HARVARD directs. As directed by HARVARD, LICENSEE shall
either pay invoiced billings related to PATENT RIGHTS directly to HARVARDs patent counsel or shall reimburse to HARVARD the amount of all fees and costs related to PATENT RIGHTS that HARVARD has paid. LICENSEE shall pay to HARVARD, or to
HARVARDs patent counsel if so directed by HARVARD, all amounts due under each invoice under this paragraph within thirty (30) days of the date of receipt of said invoice. Late payment of these invoices shall be subject to interest charges
of one and one-half percent (1 1/2%) per month. If HARVARD shall license PATENT RIGHTS outside the FIELD to a third party, HARVARD will pay to LICENSEE a sum equal to the pro-rata share of past COSTS for PATENT RIGHTS which are now
nonexclusive. HARVARD will also invoice present or future COSTS related to nonexclusive patent rights on a pro rata basis. All pro rata calculations will be made using the number of distinct companies granted a license(s) and no other bases.



7.3 HARVARD, Organix and LICENSEE shall cooperate fully in
the preparation, filing, prosecution and maintenance of PATENT RIGHTS exclusive to LICENSEE and of all patents and patent applications exclusively licensed to LICENSEE hereunder, executing all papers and instruments or requiring members of HARVARD
or of Organix to execute such papers and instruments so as to enable HARVARD to apply for, to prosecute and to maintain patent applications and patents in HARVARDs and other applicable assignees names in any country. HARVARD and LICENSEE
shall each provide to the other prompt notice as to all matters which come to its attention and which may affect the preparation, filing, prosecution or maintenance of any such patent applications or patents. After LICENSEE has shown good and
sufficient cause to justify a request that HARVARD choose alternate patent counsel, and after having made reasonable attempts to rectify the situation resulting in said good and sufficient cause, HARVARD will not unreasonably withhold consent that
alternate patent counsel be chosen. In such event, LICENSEE agrees to bear all costs associated with transfer to alternate patent counsel.



7.4 LICENSEE may elect to surrender its PATENT RIGHTS in any country upon one-hundred-twenty (120) days written notice to HARVARD. Such notice shall
not



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relieve LICENSEE from responsibility to reimburse HARVARD for patent-related expenses incurred prior to the expiration of the one-hundred-twenty (120)-day
notice period (or such longer period specified in LICENSEEs notice).



7.5 In the event HARVARD elects not to pursue, maintain or retain a particular PATENT RIGHT licensed to LICENSEE hereunder, HARVARD shall so notify LICENSEE in sufficient time for LICENSEE to assume the filing,
prosecution and/or maintenance of such application or patent at LICENSEEs expense. In such event, HARVARD shall provide to LICENSEE any authorization necessary to permit LICENSEE to pursue and/or maintain such PATENT RIGHT. LICENSEE shall have
no further royalty obligations under this Agreement with respect to any such PATENT RIGHT.



(c) Article VIII is hereby amended to read:



INFRINGEMENT



8.1 With respect
to any PATENT RIGHTS that are exclusively licensed to LICENSEE pursuant to this Agreement, LICENSEE shall have the right to prosecute in its own name and at its own expense any infringement of such patent, so long as such license is exclusive at the
time of the commencement of such action. Each party agrees to notify the other parties promptly of each infringement of such patents of which that party is or becomes aware. Before LICENSEE commences an action with respect to any infringement of
such patents, LICENSEE shall give careful consideration to the views of HARVARD and Organix and to potential effects on the public interest in making its decision whether or not to sue.



8.2 (a) If LICENSEE elects to commence an action as described above, HARVARD and Organix may, to the extent permitted
by law, elect to join as a party in that action. Regardless of whether HARVARD or Organix elects to join as a party, HARVARD and Organix shall cooperate fully with LICENSEE in connection with any such action.



(b) If HARVARD or Organix elects to join as a party pursuant to subparagraph
(a), HARVARD and/or Organix shall jointly control the action with LICENSEE.



(c) LICENSEE shall reimburse HARVARD and/or Organix for any costs HARVARD and/or Organix incurs, including reasonable attorneys fees, as part of an action brought by LICENSEE, irrespective of whether HARVARD
and/or Organix becomes a co-plaintiff.



8.3 No settlement,
consent judgment or other voluntary final disposition of the suit may be entered into without the prior written consent of HARVARD and Organix, which consent shall not be unreasonably withheld.



8.4 Recoveries or reimbursements from actions commenced pursuant to this
Article shall first be applied to reimburse LICENSEE, HARVARD and Organix for litigation costs. Any remaining recoveries or reimbursements shall be shared equally by LICENSEE, HARVARD and Organix.



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8.5 If LICENSEE elects not to exercise its right to prosecute an infringement of the PATENT RIGHTS
pursuant to this Article, HARVARD and/or Organix may do so at its own expense, controlling such action and retaining all recoveries therefrom. LICENSEE shall cooperate fully with HARVARD and/or Organix in connection with any such action.



8.6 Without limiting the generality of paragraph 11.5, HARVARD may, at
its election and by notice to LICENSEE, establish a time limit of sixty (60) days for LICENSEE to decide whether to prosecute any infringement of which HARVARD and/or Organix is or becomes aware. If, by the end of such sixty (60)-day period,
LICENSEE has not commenced such an action, HARVARD and/or Organix may prosecute such an infringement at its own expense, controlling such action and retaining all recoveries therefrom. With respect to any such infringement action prosecuted by
HARVARD and/or Organix in good faith, LICENSEE shall pay over to HARVARD and/or Organix any payments (whether or not designated as ROYALTIES) made by the alleged infringer to LICENSEE under any existing or future SUBLICENSE authorizing
LICENSED PRODUCTS, up to the amount of HARVARD and/or Organixs unreimbursed litigation expenses (including, but not limited to, reasonable attorneys fees).



8.7 If a declaratory judgment action is brought naming LICENSEE as a defendant and alleging invalidity of any of the PATENT
RIGHTS, HARVARD may elect to take over the sole defense of the action at its own expense. LICENSEE shall cooperate fully with HARVARD and Organix in connection with any such action.



2. Definitions. Capitalized terms used in this Amendment that are not otherwise defined herein shall have the
meanings set forth in the License Agreement.



3.
General. Except as expressly set forth above, the License Agreement as previously amended remains in full force and effect, without change or modification.



IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first set forth above.



For:



|                                                               |  |  |  |                            |  |          |  | 
|-------------------------------------------------------------- |  |  |  | -------------------------- |  | -------- |  | 
|HARVARD                                                        |  |  |  | BOSTON LIFE SCIENCES, INC.
|                                                               |  | 
|/s/    O. PREM
DAS                                             |  |  |  | /s/    MARC
LANSER        
|O. Prem Das, Director                                          |  |  |  | Name:                      |  | M Lanser
|Office of Technology Licensing and Industry Sponsored Research |  |  |  | Title:                     |  | MD      
|Harvard Medical School                                         |  |  |  |                           
|5/4/04                                                         |  |  |  | 5/7/04                    



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AMENDMENT TO LICENSE AGREEMENT



BETWEEN



The President and Fellow of Harvard College



and



Boston Life Sciences, Inc.,



effective as of October 15, 1996.



Re: Harvard Case No: 1194-95



(the License)



Article 2.2, the definition of Patents, shall be amended to read
as follows:



Patent(s) means the U.S. Patent Application Serial
No. 08/552,584 filed November 3, 1995 entitled Dopamine Transporter Imaging Agents, the U.S. Patent Application Serial No. 60/133,761 filed May 12, 1999 entitled Dopamine Transporter Imaging Agents and
U.S. Patent Application Serial No. 09/568,106, filed May 10, 2000, entitled Dopamine Transporter Imaging Agents, and any foreign (Non-U.S.) counterparts including continuations, divisions or extensions and all patents which
issue therefrom in any country. It also includes continuations-in-part for which Inventors are legally listed among the inventive entity and any foreign (Non-U.S.) counterparts including continuations, divisions or extensions and all patents which
issue therefrom in any country.



All other terms and conditions of the License
shall remain unchanged.



This amendment shall become effective on
August 22, 2001.



|                           |  |                                           |  |                             |  |                                          |  |        
|-------------------------- |  | ----------------------------------------- |  | --------------------------- |  | ---------------------------------------- |  | -------
|BOSTON LIFE SCIENCES, INC. |  |                                           |  | PRESIDENT AND FELLOWS OF   
|                           |  |                                           |  | HARVARD COLLEGE            
|                           |  |                                          
|/s/    LESLIE M.
LEVINE    |  |                                           |  | /s/    SUSANNE E.
CHURCHILL
|Name:                      |  | Leslie M. Levine, V.M.D., Ph.D., J.D.     |  |                             |  | Susanne E. Churchill                    
|Position:                  |  | Sr. Vice President, Intellectual Property |  |                             |  | Director, Office of Technology Licensing
|Date:                      |  | August 22, 2001                           |  |                             |  | Date:                                    |  | 9/19/01



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LICENSE AGREEMENT

BETWEEN

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

AND



Boston
Life Sciences, Inc.



Effective as of October 15, 1996



Re: Harvard Case No: 1194-95



In consideration of the mutual promises and covenants set forth below, the parties hereto
agree as follows:



ARTICLE I



DEFINITIONS



As used in this Agreement, the following terms shall have the following meanings:



|1.1 | AFFILIATE: any company, corporation, or business in which LICENSEE owns or controls at least fifty percent (50%) of the voting stock or other ownership. Unless otherwise
specified, the term LICENSEE includes AFFILIATES.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|1.2 | BIOLOGICAL MATERIALS: the materials supplied by HARVARD (identified in Appendix B) together with any progeny, mutants, or derivatives thereof supplied by HARVARD or created by
LICENSEE.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|1.3 | FIELD: All field s of use.
|--- | --------------------------



|1.4 | HARVARD: President and Fellows of Harvard College, a nonprofit Massachusetts educational corporation having offices at the Office for Technology and Trademark Licensing, 124 Mt.
Auburn Street, Suite 410-South, Cambridge, Massachusetts 02138.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|1.5 | LICENSED PROCESSES: the processes covered by PATENT RIGHTS or processes utilizing BIOLOGICAL MATERIALS or some portion thereof.
|--- | -------------------------------------------------------------------------------------------------------------------------------



|1.6 | LICENSED PRODUCTS: products covered by PATENT RIGHTS or products made or services provided in accordance with or by means of LICENSED PROCESSES or products made or services provided
utilizing BIOLOGICAL MATERIALS or incorporating some portion of BIOLOGICAL MATERIALS.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|1.7 | LICENSEE: Boston Life Sciences, Inc. a corporation organized under the laws of Massachusetts having its principal offices at Reservoir Place, 1601 Trapelo Road, Waltham, MA 02154.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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|1.8 | NET SALES: the amount billed, invoiced, or received (whichever occurs first) for sales, leases, or other transfers of LICENSED PRODUCTS, less:
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------



| | (a) | customary trade, quantity or cash discounts and non-affiliated brokers or agents commissions actually allowed and taken;
| | --- | --------------------------------------------------------------------------------------------------------------------------



| | (b) | amounts repaid or credited by reason of rejection or return; and
| | --- | ----------------------------------------------------------------



| | (c) | to the extent separately stated on purchase orders, invoices, or other documents of sale, taxes levied on and/or other governmental charges made as to production, sale,
transportation, delivery or use and paid by or on behalf of LICENSEE or sublicensees.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | reasonable charges for delivery or transportation provided by third parties, if separately stated.
| | --- | --------------------------------------------------------------------------------------------------



NET SALES also includes the fair market value of any non-cash consideration received by LICENSEE or sublicensees for the
sale, lease, or transfer of LICENSED PRODUCTS.



|1.9 | NON-COMMERCIAL RESEARCH PURPOSES: use of PATENT RIGHTS and/or BIOLOGICAL MATERIALS for academic research or other not-for-profit scholarly purposes which are undertaken at a
non-profit or governmental institution that does not use the PATENT RIGHTS and/or BIOLOGICAL MATERIALS in the production or manufacture of products for sale or the performance of services for a fee.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|1.10 | NON-ROYALTY SUBLICENSE INCOME: Sublicense issue fees, sublicense maintenance fees, sublicense milestone payments, and similar non-royalty payments made by sublicensees to LICENSEE
on account of sublicenses pursuant to this Agreement.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|1.11 | PATENT RIGHTS: United States patent application Serial No. 08/552,584 filed November third (3) 1995, the inventions described and claimed therein, and any divisions,
continuations, continuations-in-part to the extent the claims are directed to subject matter specifically described in USSN 08/552,584 and are dominated by the claims of the existing PATENT RIGHTS, patents issuing thereon or reissues thereof, and
any and all foreign patents and patent applications corresponding thereto, all to the extent owned or controlled by HARVARD.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|1.12 | TERRITORY: Worldwide.
|---- | ---------------------



|1.13 | The terms Public Law 96-517 and Public Law 98-620 include all amendments to those statutes.
|---- | -----------------------------------------------------------------------------------------------



|1.14 | The terms sold and sell include, without limitation, leases and other transfers and similar transactions.
|---- | -------------------------------------------------------------------------------------------------------------



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ARTICLE II



REPRESENTATIONS



|2.1 | HARVARD is owner by assignment from Dr. Bertha Madras, Dr. Alun Jones and Dr. Ashfaq Mahmood; MIT is owner by assignment from Dr. Alan Davison; and Organix Inc.
is owner by assignment from Dr. Peter Meltzer and Dr. Paul Blundell, of their entire right, title and interest in United States Patent Application Serial No. 08/552,584 filed November third (3) 1995 entitled Dopamine
Transporter Imaging Agent (H.U. Case # 1194-95), in the foreign patent applications corresponding thereto, and in the inventions described and claimed therein.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|2.2 | HARVARD has the authority to issue licenses under PATENT RIGHTS.
|--- | ----------------------------------------------------------------



|2.3 | HARVARD is committed to the policy that ideas or creative works produced at HARVARD should be used for the greatest possible public benefit, and believes that every reasonable
incentive should be provided for the prompt introduction of such ideas into public use, all in a manner consistent with the public interest.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|2.4 | LICENSEE is prepared and intends to diligently develop the invention and to bring products to market which are subject to this Agreement.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------



|2.5 | LICENSEE is desirous of obtaining an exclusive license in the TERRITORY in order to practice the above-referenced invention covered by PATENT RIGHTS in the United States and in
certain foreign countries, and to manufacture, use and sell in the commercial market the products made in accordance therewith, and HARVARD is desirous of granting such a license to LICENSEE in accordance with the terms of this Agreement.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



ARTICLE III



GRANT OF RIGHTS



|3.1 | HARVARD hereby grants to LICENSEE and LICENSEE accepts, subject to the terms and conditions hereof, in the TERRITORY and in the FIELD:
|--- | --------------------------------------------------------------------------------------------------------------------------------------



| | (a) | an exclusive commercial license under PATENT RIGHTS, and
| | --- | --------------------------------------------------------



| | (b) | a license to use BIOLOGICAL MATERIALS
| | --- | -------------------------------------



to make and have made, to use and have used, to sell and have sold the LICENSED PRODUCTS, and to practice the LICENSED PROCESSES, for the life of the
PATENT RIGHTS. Such licenses shall include the right to grant sublicenses, subject to HARVARDs approval, which approval shall not be unreasonably withheld. In order to provide LICENSEE with commercial exclusivity for so long as the license
under PATENT RIGHTS remains exclusive, HARVARD agrees that it will not grant licenses under PATENT RIGHTS to others except as required by HARVARDs obligations in paragraph 3.2(a) or as permitted in paragraph 3.2(b) and that it will not provide
BIOLOGICAL MATERIALS to others for any commercial purpose.



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|3.2 | The granting and exercise of this license is subject to the following conditions:
|--- | ---------------------------------------------------------------------------------



| | (a) | HARVARDs Statement of Policy in Regard to Inventions, Patents and Copyrights, dated March 17, 1986, Public Law 96-517, Public Law 98-620, and HARVARDs
obligations under agreements with other sponsors of research. Any right granted in this Agreement greater than that permitted under Public Law 96-517, or Public Law 98-620, shall be subject to modification as may be required to conform to the
provisions of those statutes.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | HARVARD reserves the right to
| | --- | -----------------------------



| | (i) | make, use, and provide the BIOLOGICAL MATERIALS to others on a non-exclusive basis, and grant others non-exclusive licenses to make and use the BIOLOGICAL MATERIALS, all for
NONCOMMERCIAL RESEARCH PURPOSES; and
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (ii) | make and use, and grant to others non-exclusive licenses to make and use for NON-COMMERCIAL RESEARCH PURPOSES the subject matter described and claimed in PATENT RIGHTS.
| | ---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | LICENSEE shall use diligent efforts to effect introduction of the LICENSED PRODUCTS into the commercial market as soon as practicable, consistent with sound and reasonable business
practice and judgment; thereafter, until the expiration of this Agreement, LICENSEE shall endeavor to keep LICENSED PRODUCTS reasonably available to the public.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | At any time after 2 (two) years from the effective date of this Agreement, HARVARD may terminate or render this license nonexclusive if, in HARVARDs reasonable judgment, the
Progress Reports furnished by LICENSEE do not demonstrate that LICENSEE:
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (i) | has put the licensed subject matter into commercial use in the country or countries hereby licensed, directly or through a sublicense, and is not keeping the licensed subject matter
reasonably available to the public, or
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (ii) | is engaged in research, development, manufacturing, marketing or sublicensing activity appropriate to achieving 3.2(d)(i).
| | ---- | --------------------------------------------------------------------------------------------------------------------------



Additional, specific performance milestones which, if not complied with, may
result in HARVARD terminating or rendering this license non exclusive:



| | (iii) | LICENSEE to appoint within twelve (12) months of the execution of this Agreement, after consultation with the inventors, a consultant to advise on technetium kit development.
| | ----- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (iv) | LICENSEE shall provide funding for a Physician Sponsored or corporate IND within six (6) months of successful completion of images in
| | ---- | -------------------------------------------------------------------------------------------------------------------------------------



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| | experimental primates, pharmakokenetic studies, and biodistribution, and toxicity studies.
| | ------------------------------------------------------------------------------------------



| | (v) | Following the Physician Sponsored IND a decision will be taken by LICENSEE, in consultation with INVENTORS, regarding Technepines suitability as a lead compound. If suitable,
LICENSEE shall proceed to file a Corporate Sponsored IND. If Technepine is not a suitable lead compound then LICENSEE shall proceed by filing a Physician Sponsored IND with a more suitable lead compound if so generated by research of the INVENTORS,
sponsored by LICENSEE, during the 18 (eighteen) month period from the execution of this Agreement, provided that the necessary preclinical studies been successfully completed, as provided in paragraph (iv) above.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (vi) | One year from successful completion of Physician Sponsored IND LICENSEE shall submit a Corporate Sponsored IND.
| | ---- | ---------------------------------------------------------------------------------------------------------------



| | (vii) | Within two years of a successful Corporate Sponsored IND LICENSEE shall submit an NDA filing.
| | ----- | ---------------------------------------------------------------------------------------------



| | (e) | In all sublicenses granted by LICENSEE hereunder, LICENSEE shall include a requirement that the sublicensee use diligent efforts to bring the subject matter of the sublicense into
commercial use as quickly as is reasonably possible. LICENSEE shall further provide in such sublicenses that such sublicenses are subject and subordinate to the terms and conditions of this Agreement, except: (i) the sublicensee may not further
sublicense; and (ii) the rate of royalty on NET SALES paid by the sublicensee to the LICENSEE. Copies of all sublicense agreements shall be provided promptly to HARVARD.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (f) | During the period of exclusivity of this license in the United States, LICENSEE shall cause any LICENSED PRODUCT produced for sale in the United States to be manufactured
substantially in the United States.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|3.3 | All rights reserved to the United States Government and others under Public Law 96-517, and Public Law 98-620, shall remain and shall in no way be affected by this Agreement.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



ARTICLE IV



ROYALTIES



|4.1 | LICENSEE shall pay to HARVARD a non-refundable license royalty fee in the sum of Three Hundred Thousand Dollars ($300,000). One Hundred and Fifty Thousand ($150,000) to be paid upon
execution of this Agreement, and One Hundred and Fifty Thousand six (6) months later.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|4.2 | (a) LICENSEE shall pay to HARVARD during the term of this Agreement a royalty of six percent (6%) of NET SALES by LICENSEE up to fifty (50) million dollars; seven percent
(7%) on NET SALES by LICENSEE from fifty (50) to one hundred (100)
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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million dollars; and Eight (8%) on NET SALES by LICENSEE over one hundred (100) million
dollars. In the case of sublicenses, LICENSEE shall, instead of the foregoing, pay to HARVARD a royalty of thirty percent (30%) of royalties received by LICENSEE on NET SALES by sublicensee up to fifty (50) million dollars; thirty three
percent (33%) of royalties received by LICENSEE on NET SALES by sublicensee from fifty (50) to one hundred (100) million dollars; and thirty six percent (36%) of royalties received by LICENSEE on NET Sales by sublicensee over one
hundred (100) million dollars. LICENSEE shall also pay to HARVARD a royalty of twenty five percent (25%) of NON-ROYALTY SUBLICENSE INCOME. This shall however exclude payments received from sublicensee for research and development.



| | (b) | If the license pursuant to this Agreement is converted to a nonexclusive one and if other non-exclusive licenses in the same field and territory are granted, the above royalties
shall not exceed the royalty rate to be paid by other licensees in the same field and territory during the term of the non-exclusive license.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | On sales between LICENSEE and its AFFILIATES or sublicensees for resale, the royalty shall be paid on the NET SALES of the AFFILIATE or sublicensee.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------



|4.3 | Milestone royalty payments:
|--- | ---------------------------



|                                                      |  |   |        
|----------------------------------------------------- |  | - | -------
|Upon filing an IND                                    |  | $ | 50,000 
|Upon successful completion of phase II clinical trial |  | $ | 100,000
|Upon NDA Filing                                       |  | $ | 100,000
|Upon NDA Approval                                     |  | $ | 250,000



ARTICLE V



REPORTING



|5.1 | Prior to signing this Agreement, LICENSEE has provided to HARVARD a written research and development plan (as appendix A of Sponsored Research Agreement).
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------



|5.2 | No later than sixty (60) days after June 30 of each calendar year, LICENSEE shall provide to HARVARD a written annual Progress Report describing progress on research and
development, regulatory approvals, manufacturing, sublicensing, marketing and sales during the most recent twelve (12) month period ending June 30 and plans for the forthcoming year. If multiple technologies are covered by the license
granted hereunder, the Progress Report shall provide the information set forth above for each technology. If progress differs from that anticipated in the plan required under Paragraph 5.1, LICENSEE shall explain the reasons for the difference and
propose a modified research and development plan for HARVARDs review and approval. LICENSEE shall also provide any reasonable  additional data HARVARD requires to evaluate LICENSEEs performance.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



- 6 -



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|5.3 | LICENSEE shall report to HARVARD the date of first sale of LICENSED PRODUCTS (or results of LICENSED PROCESSES) in each country within thirty (30) days of occurrence.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



|5.4 | (a) LICENSEE shall submit to HARVARD within sixty (60) days after each calendar half year ending June 30 and December 31, a Royalty Report setting forth for such half
year at least the following information:
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (i) | the number of LICENSED PRODUCTS sold by LICENSEE, its AFFILIATES and sublicensees in each country;
| | --- | --------------------------------------------------------------------------------------------------



| | (ii) | total billings for such LICENSED PRODUCTS;
| | ---- | ------------------------------------------



| | (iii) | an accounting for all LICENSED PROCESSES used or sold;
| | ----- | ------------------------------------------------------



| | (iv) | deductions applicable to determine the NET SALES thereof;
| | ---- | ---------------------------------------------------------



| | (v) | the amount of NON-ROYALTY SUBLICENSE INCOME received by LICENSEE; and
| | --- | ---------------------------------------------------------------------



| | (vi) | the amount of royalty due thereon, or, if no royalties are due to HARVARD for any reporting period, the statement that no royalties are due.
| | ---- | --------------------------------------------------------------------------------------------------------------------------------------------



Such report shall be certified as correct by an officer of LICENSEE and
shall include a detailed listing of all deductions from royalties.



| | (b) | LICENSEE shall pay to HARVARD with each such Royalty Report the amount of royalty due with respect to such half year. If multiple technologies are covered by the license granted
hereunder, LICENSEE shall specify which PATENT RIGHTS and BIOLOGICAL MATERIALS are utilized for each LICENSED PRODUCT and LICENSED PROCESS included in the Royalty Report.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | All payments due hereunder shall be deemed received when funds are credited to Harvards bank account and shall be payable by check or wire transfer in United States dollars.
Conversion of foreign currency to U.S. dollars shall be made at the conversion rate existing in the United States (as reported in the New York Times or the Wall Street Journal) on the last working day of each royalty period. No transfer, exchange,
collection or other charges shall be deducted from such payments.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | All such reports shall be maintained in confidence by HARVARD except as required by law; however, HARVARD may include in its usual reports annual amounts of royalties paid.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (e) | Late payments shall be subject to a charge of one and one half percent (1 1/2%) per month, or $250, whichever is greater.
| | --- | -------------------------------------------------------------------------------------------------------------------------



- 7 -



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ARTICLE VI



RECORD KEEPING



|6.1 | LICENSEE shall keep, and shall require its AFFILIATES and sublicensees to keep, accurate records (together with supporting documentation) of LICENSED PRODUCTS made, used or sold
under this Agreement, appropriate to determine the amount of royalties due to HARVARD hereunder. Such records shall be retained for at least three (3) years following the end of the reporting period to which they relate. They shall be available
during normal business hours for examination by an accountant selected by HARVARD, for the sole purpose of verifying reports and payments hereunder. In conducting examinations pursuant to this paragraph, HARVARDs accountant shall have access
to all records which HARVARD reasonably believes to be relevant to the calculation of royalties under Article IV.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|6.2 | HARVARDs accountant shall not disclose to HARVARD any information other than information relating to the accuracy of reports and payments made hereunder.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------



|6.3 | Such examination by HARVARDs accountant shall be at HARVARDs expense, except that if such examination shows an underreporting or underpayment in excess of five percent
(5%) for any twelve (12) month period, then LICENSEE shall pay the cost of such examination as well as any additional sum that would have been payable to HARVARD had the LICENSEE reported correctly, plus interest on said sum at the rate of
one and one half per cent (1 1/2%) per month.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



ARTICLE VII



DOMESTIC AND FOREIGN PATENT FILING AND
MAINTENANCE



|7.1 | Upon execution of this Agreement, LICENSEE shall reimburse HARVARD for all reasonable expenses HARVARD has incurred for the preparation, filing, prosecution and maintenance of
PATENT RIGHTS. Thereafter, LICENSEE shall reimburse HARVARD for all such future expenses upon receipt of invoices from HARVARD. Late payment of these invoices shall be subject to interest charges of one and one-half percent (1 1/2%) per month.
HARVARD shall, in its sole discretion, be responsible for the preparation, filing, prosecution and maintenance of any and all patent applications and patents included in PATENT RIGHTS. HARVARD shall consult with LICENSEE as to the preparation,
filing, prosecution and maintenance of such patent applications and patents and shall furnish to LICENSEE copies of documents relevant to any such preparation, filing, prosecution or maintenance.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|7.2 | HARVARD and LICENSEE shall cooperate fully in the preparation, filing, prosecution and maintenance of PATENT RIGHTS and of all patents and patent applications
licensed to LICENSEE hereunder, executing all papers and instruments or requiring members of HARVARD to execute such papers and instruments so as to enable HARVARD to apply for, to prosecute and to maintain patent applications and patents in
HARVARDs name in any country. Each party shall provide to the other prompt notice as to all matters which
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



- 8 -



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| | come to its attention and which may affect the preparation, filing, prosecution or maintenance of any such patent applications or patents.
| | ------------------------------------------------------------------------------------------------------------------------------------------



|7.3 | LICENSEE may elect to surrender its PATENT RIGHTS in any country upon sixty (60) days written notice to HARVARD. Such notice shall not relieve LICENSEE from responsibility to
reimburse HARVARD for patent-related expenses incurred prior to the expiration of the (60)-day notice period (or such longer period specified in LICENSEEs notice).
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



ARTICLE VIII



INFRINGEMENT



|8.1 | With respect to any PATENT RIGHTS that are exclusively licensed to LICENSEE pursuant to this Agreement, LICENSEE shall have the right to prosecute in its own name and at its own
expense any infringement of such patent, so long as such license is exclusive at the time of the commencement of such action. HARVARD agrees to notify LICENSEE promptly of each infringement of such patents of which HARVARD is or becomes aware.
Before LICENSEE commences an action with respect to any infringement of such patents, LICENSEE shall give careful consideration to the views of HARVARD and to potential effects on the public interest in making its decision whether or not to sue.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|8.2 | (a) If LICENSEE elects to commence an action as described above, Harvard may, to the extent permitted by law, elect to join as a party in that action. Regardless of whether HARVARD
elects to join as a party, HARVARD shall cooperate fully with LICENSEE in connection with any such action.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | If HARVARD elects to join as a party pursuant to subparagraph (a), HARVARD shall jointly control the action with LICENSEE.
| | --- | --------------------------------------------------------------------------------------------------------------------------



| | (c) | LICENSEE shall reimburse HARVARD for any costs HARVARD incurs, including reasonable attorneys fees, as part of an action brought by LICENSEE, irrespective of whether HARVARD
becomes a co-plaintiff.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|8.3 | If LICENSEE elects to commence an action as described above, LICENSEE may deduct from its royalty payments to HARVARD with respect to the patent(s) subject to suit an amount not
exceeding fifty percent (50%) of LICENSEEs expenses and costs of such action, including reasonable attorneys fees; provided, however, that such reduction shall not exceed fifty percent (50%) of the total royalty due to HARVARD
with respect to the patent(s) subject to suit for each calendar year. If such fifty percent (50%) of LICENSEEs expenses and costs exceeds the amount of royalties deducted by LICENSEE for any calendar year, LICENSEE may to that extent
reduce the royalties due to HARVARD from LICENSEE in succeeding calendar years, but never by more than fifty percent (50%) of the total royalty due in any one year with respect to the patent(s) subject to suit.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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|8.4 | No settlement, consent judgment or other voluntary final disposition of the suit may be entered into without the prior written consent of HARVARD, which consent shall not be
unreasonably withheld.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|8.5 | Recoveries or reimbursements from actions commenced pursuant to this Article shall first be applied to reimburse LICENSEE and HARVARD for litigation costs not paid from royalties
and then to reimburse HARVARD for royalties deducted by LICENSEE pursuant to paragraph 8.3. Any remaining recoveries or reimbursements shall be shared equally by LICENSEE and HARVARD.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|8.6 | If LICENSEE elects not to exercise its right to prosecute an infringement of the PATENT RIGHTS pursuant to this Article, HARVARD may do so at its own expense, controlling such
action and retaining all recoveries therefrom. LICENSEE shall cooperate fully with HARVARD in connection with any such action.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|8.7 | Without limiting the generality of paragraph 8.6, HARVARD may, at its election and by notice to LICENSEE, establish a time limit of sixty (60) days for, LICENSEE to decide
whether to prosecute any infringement of which HARVARD is or becomes aware. If, by the end of such sixty (60)-day period, LICENSEE has not commenced such an action, HARVARD may prosecute such an infringement at its own expense, controlling such
action _ and retaining all recoveries therefrom. With respect to any such infringement action prosecuted by HARVARD in good faith, LICENSEE shall pay over to Harvard any payments (whether or not designated as royalties) made by the
alleged infringer to LICENSEE under any existing or future sublicense authorizing LICENSED PRODUCTS, up to the amount of HARVARDs unreimbursed litigation expenses (including, but not limited to, reasonable attorneys fees).
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|8.8 | If a declaratory judgment action is brought naming LICENSEE as a defendant and alleging invalidity of any of the PATENT RIGHTS, HARVARD may elect to take over the sole defense of
the action at its own expense. LICENSEE shall cooperate fully with HARVARD in connection with any such action.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



ARTICLE IX



TERMINATION OF AGREEMENT



|9.1 | This Agreement, unless terminated as provided herein, shall remain in effect until the last patent or patent application in PATENT RIGHTS has expired or been abandoned.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|9.2 | HARVARD may terminate this Agreement as follows:
|--- | ------------------------------------------------



| | (a) | If LICENSEE does not make a payment due hereunder and fails to cure such non-payment (including the payment of interest in accordance with paragraph 5.4(e)) within forty-five
(45) days after the date of notice in writing of such non-payment by HARVARD.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | If LICENSEE defaults in its obligations under paragraph 10.4(c)and(d) to procure and maintain insurance.
| | --- | --------------------------------------------------------------------------------------------------------



- 10 -



---

| | (c) | If LICENSEE shall become insolvent, shall make an assignment for the benefit of creditors, or shall have a petition in bankruptcy filed for or against it. Such termination shall be
effective immediately upon HARVARD giving written to LICENSEE.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | If an examination by Harvards accountant pursuant to Article VI shows an underreporting or underpayment by LICENSEE in excess of 20% for any twelve (12) month period.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (e) | If LICENSEE is convicted of a felony relating to the manufacture, use, or sale of LICENSED PRODUCTS.
| | --- | ----------------------------------------------------------------------------------------------------



| | (f) | Except as provided in subparagraphs (a), (b), (c), (d), (e) and (f) above, if LICENSEE defaults in the performance of any obligations under this Agreement and the default
has not been remedied within ninety (90) days after the date of notice in writing of such default by HARVARD.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|9.3 | LICENSEE shall provide, in all sublicenses granted by it under this Agreement, that LICENSEEs interest in such sublicenses shall at HARVARDs option terminate or be
assigned to HARVARD upon termination of this Agreement.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|9.4 | LICENSEE may terminate this Agreement by giving ninety (90) days advance written notice of termination to HARVARD and paying a termination fee of twenty thousand dollars
($20,000). Upon termination, LICENSEE shall submit a final Royalty Report to HARVARD and any royalty payments and unreimbursed patent expenses invoiced by HARVARD shall become immediately payable.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|9.5 | Upon termination pursuant to Paragraph 9.2, whether by HARVARD or by LICENSEE, LICENSEE shall cease all use of the BIOLOGICAL MATERIALS and shall, upon request, return or destroy
(at HARVARDs option) all BIOLOGICAL MATERIALS under its control or in its possession.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|9.6 | Paragraphs 6.1, 6.2, 6.3, 7.1, 8.5, 9.4, 9.5, 9.6, 10.2, 10.4, 10.5, 10.8 and 10.9 of this Agreement shall survive termination.
|--- | -------------------------------------------------------------------------------------------------------------------------------



ARTICLE X



GENERAL



|10.1 | HARVARD does not warrant the validity of the PATENT RIGHTS licensed hereunder and makes no representations whatsoever with regard to the scope of the licensed PATENT RIGHTS or that
such PATENT RIGHTS or BIOLOGICAL MATERIALS may be exploited by LICENSEE, an AFFILIATE, or sublicensee without infringing other patents.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.2 | HARVARD EXPRESSLY DISCLAIMS ANY AND ALL IMPLIED OR EXPRESS WARRANTIES AND MAKES NO EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR
PURPOSE OF THE
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



- 11 -



---

| | PATENT RIGHTS, BIOLOGICAL MATERIALS, OR INFORMATION SUPPLIED BY HARVARD, LICENSED PROCESSES OR LICENSED PRODUCTS CONTEMPLATED BY THIS AGREEMENT. Further
HARVARD has made no investigation and makes no representation that the BIOLOGICAL MATERIALS supplied by it or the methods used in making or using such materials are free from liability for patent infringement.
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.3 | LICENSEE shall not distribute or release the BIOLOGICAL MATERIALS to others except to further the purposes of this Agreement. LICENSEE shall protect the BIOLOGICAL MATERIALS at
least as well as it protects its own valuable tangible personal property and shall take measures to protect the BIOLOGICAL MATERIALS from any claims by third parties including creditors and trustees in bankruptcy.
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.4 | (a) LICENSEE shall indemnify, defend and hold harmless HARVARD and its current or former directors, governing board members, trustees, officers, faculty, medical and professional
staff, employees, students, and agents and their respective successors, heirs and assigns (collectively, the Indemnitees), against any liability, damage, loss or expenses (including reasonable attorneys fees and expenses of
litigation) incurred by or imposed upon the Indemnitees or any of them in connection with any claims, suits, actions, demands or judgments arising out of any theory of product liability (including, but not limited to, actions in the form of tort,
warranty, or strict liability) concerning any product, process or service made, used or sold pursuant to any right or license granted under this Agreement.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | LICENSEE shall, at its own expense, provide attorneys reasonably acceptable to HARVARD to defend against any actions brought or filed against any Indemnitee hereunder with respect
to the subject of indemnity contained herein, whether or not such actions are rightfully brought.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | Beginning at the time any such product, process or service is being commercially distributed or sold (other than for the purpose of obtaining regulatory approvals)
by LICENSEE or by a sublicensee, AFFILIATE or agent of LICENSEE, LICENSEE shall, at its sole cost and expense, procure and maintain commercial general liability insurance in amounts not less than $2,000,000 per incident and $2,000,000 annual
aggregate and naming the Indemnitees as additional insureds. During clinical trials of any such product, process or service, LICENSEE shall, at its sole cost and expense, procure and maintain commercial general liability insurance in such equal or
lesser amount as HARVARD shall require, naming the Indemnitees as additional insureds. Such commercial general liability insurance shall provide (i) product liability coverage and (ii) broad form contractual liability coverage for
LICENSEEs indemnification under this Agreement. If LICENSEE elects to self-insure all or part of the limits described above (including deductibles or retentions which are in excess of $250,000 annual aggregate) such self-insurance program must
be acceptable to HARVARD and the Risk Management Foundation of the Harvard Medical Institutions, Inc. in their sole discretion. The minimum amounts of insurance coverage required shall not be construed to create
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



- 12 -



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| | a limit of LICENSEEs liability with respect to its indemnification under this Agreement.
| | -----------------------------------------------------------------------------------------



| | (d) | LICENSEE shall provide HARVARD with written evidence of such insurance upon request of HARVARD. LICENSEE shall provide HARVARD with written notice at least fifteen (15) days
prior to the cancellation, non-renewal or material change in such insurance; if LICENSEE does not obtain replacement insurance providing comparable coverage within such fifteen (15) day period, HARVARD shall have the right to terminate this
Agreement effective at the end of such fifteen (15) day period without notice or any additional waiting periods.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (e) | LICENSEE shall maintain such commercial general liability insurance beyond the expiration or termination of this Agreement during (i) the period that any product, process, or
service, relating to, or developed pursuant to, this Agreement is being commercially distributed or sold by LICENSEE or by a sublicensee, AFFILIATE or agent of LICENSEE and (ii) a reasonable period after the period referred to in (e)(i) above
which in no event shall be less, than fifteen (15) years.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.5 | LICENSEE shall not use HARVARDs name or insignia, or any adaptation of them, or the name of any of HARVARDs inventors in any advertising, promotional or sales literature
without the prior written approval of HARVARD.
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.6 | Without the prior written approval of HARVARD in each instance, neither this Agreement nor the rights granted hereunder shall be transferred or assigned in whole or in part by
LICENSEE to any person whether voluntarily or involuntarily, by operation of law or otherwise. This Agreement shall be binding upon the respective successors, legal representatives and assignees of HARVARD and LICENSEE.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.7 | The interpretation and application of the provisions of this Agreement shall be governed by the laws of the Commonwealth of Massachusetts.
|---- | ------------------------------------------------------------------------------------------------------------------------------------------



|10.8 | LICENSEE shall comply with all applicable laws and regulations. In particular, it is understood and acknowledged that the transfer of certain commodities and technical data is
subject to United States laws and regulations controlling the export of such commodities and technical data, including all Export Administration Regulations of the United States Department of Commerce. These laws and regulations among other things,
prohibit or require a license for the export of certain types of technical data to certain specified countries. LICENSEE hereby agrees and gives written assurance that it will comply with all United States laws and regulations controlling the export
of commodities and technical data, that it will be solely responsible for any violation of such by LICENSEE or its AFFILIATES or sublicensees, and that it will defend and hold HARVARD harmless in the event of any legal action of any nature
occasioned by such violation.
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.9 | LICENSEE agrees (i) to obtain all regulatory approvals required for the manufacture and sale of LICENSED PRODUCTS and LICENSED PROCESSES and (ii) to
utilize appropriate patent marking on such LICENSED PRODUCTS. LICENSEE also agrees to
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



- 13 -



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| | register or record this Agreement as is required by law or regulation in any country where the license is in effect.
| | --------------------------------------------------------------------------------------------------------------------



|10.10 | Any notices to be given hereunder shall be sufficient if signed by the party (or partys attorney) giving same and either (a) delivered in person, or (b) mailed
certified mail return receipt requested, or (c) faxed to other party if the sender has evidence of successful transmission and if the sender promptly sends the original by ordinary mail, in any event to the following addresses:
|----- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



If to LICENSEE:



Boston Life Sciences, Inc.

31 Newbury Street, Suite 300

Boston, MA
02116



Fax No: 617 425 0996



If to Harvard to:



Office for Technology and Trademark Licensing

Harvard University

124 Mt. Auburn Street,
Suite 410

South Cambridge, MA 02138



Fax No.: 617-495-9568



By such notice either party may change their address for future notices.



Notices delivered in person shall be deemed given on the date delivered. Notices sent by fax shall be deemed given on the
date faxed. Notices mailed shall be deemed given on the date postmarked on the envelope.



|10.11 | Should a court of competent jurisdiction later hold any provision of this Agreement to be invalid, illegal, or unenforceable, and such holding is not reversed on appeal, it shall be
considered severed from this Agreement. All other provisions, rights and obligations shall continue without regard to the severed provision, provided that the remaining provisions of this Agreement are in accordance with the intention of the
parties.
|----- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.12 | In the event of any controversy or claim arising out of or relating to any provision of this Agreement or the breach thereof, the parties shall try to settle such
conflict amicably between themselves. Subject to the limitation stated in the final sentence of this section, any such conflict which the parties are unable to resolve promptly shall be settled through arbitration conducted in accordance with the
rules of the American Arbitration Association. The demand for arbitration shall be filed within a reasonable time after the controversy or claim has arisen, and in no event after the date upon which institution of legal proceedings based on such
controversy or claim would be barred by the applicable statute of limitation. Such arbitration shall be held in Boston, Massachusetts. The award through arbitration shall be final and binding. Either party may enter any such award in a
|----- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



- 14 -



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| | court having jurisdiction or may make application to such court for judicial acceptance of the award and an order of enforcement, as the case may be.
Notwithstanding the foregoing, either party may, without recourse to arbitration, assert against the other party a third-party claim or cross-claim in any action brought by a third party, to which the subject matter of this Agreement may be
relevant.
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|10.13 | This Agreement constitutes the entire understanding between the parties and neither party shall be obligated by any condition or representation other than those expressly stated
herein or as may be subsequently agreed to by the parties hereto in writing.
|----- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed by their duly authorized representatives.



|                                              |  |  |  |                      
|--------------------------------------------- |  |  |  | ---------------------
|PRESIDENT AND FELLOWS OF HARVARD COLLEGE      |  |  |  | LICENSEE             
|                                              |  | 
|/s/    JOYCE BRINTON                          |  |  |  | /s/    MARC E. LANSER
|Joyce Brinton, Director                       |  |  |  | Signature            
|Office for Technology and Trademark Licensing |  |  |  |                      
|                                              |  | 
|                                              |  |  |  | Marc E. Lanser       
|                                              |  |  |  | Name                 
|                                              |  | 
|                                              |  |  |  | Exec VP              
|                                              |  |  |  | Title                
|                                              |  | 
|10/16/96                                      |  |  |  | 10/18/96             
|Date                                          |  |  |  | Date                 



- 15 -



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Appendix B



Biomaterials: None