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Document Control Office (7407 M) Office of Pollution Prevention and Taxies (OPPT) Environmental Protection Agency EPA East Building, Room E6428 (202-564-8930} 1201 Constitution Avenue, NW Washington, DC 20460 

### Attention: TSCA Section 4 Docket 10 Number EPA-HQ-OPPT-2009-0112 To Whom 

### It May Concern: 

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Society of Chemiol Manufacturers &Affiliates

August29, 2012



### RE: Proposed Test Plan; Testing ofCertain High ProductionVolume Chemicals; Third GroupofChemicals. Federal Register76 (204), 65385-65410, October21, 2011. 1-Propanesulfonicacid, 2-hydroxy-3-(2-propen-1-yloxy)-, sodium salt (1 :1) (CAS No. 52556-42-0)
The COPS-1 Consortium, a cost-sharing consortium formed and managed underthe Society of Chemical Manufacturers and Affiliates (SOCMA) submits this test plan to satisfy the testing requirements ofthe subjecttest rule for 1-propanesulfonicacid, 2-hydroxy-3-(2-propen-1-yloxy)-

, sodium salt (1:1) (CAS No. 52556-42-0), also known as COPS-1. The consortium agrees to conduct the following studies or provide read across data on appropriate compounds that can be bridged to satisfy one or more ofthe requirements in compliance with the test rule and according to current OPPTS Harmonized Guidelines. Test Facility The COPS-1 Consortium has entered a contract to perform the studies outlined in this test plan atthe following testing laboratory; WIL Research Europe Hambakenwetering 7 5231 DO 's-Hertogenbosch The Netherlands Phone: +31 (0) 73 640 6700 Fax: +31 (0) 73 640 6799 www.wilresearch.com 1111111111111111111111111111111111111111111111111111111111111111 40120000085


## CONTAINS NO CBI

# ~ 6•ChemStewards' APROGAAMOf SOCMA iBSO 1"1 S! f,JVy Su!lC 700 •W;JSII:ngtcm DC 20036 .S81 0 •Tel 202 72 I 41 OC • FJx. 202-296-8120 • www socma.(Oill

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Test Material Identification: The test item will be a typical commercial product as supplied by a memberofthe Consortium with details ofpurity and known properties. The integrity ofdata supplied relating to the identification, purity and stability ofthe test item will be the responsibility ofthe Sponsor. Storage: The test item will be stored at room temperature, in the dark, unless otherwise specified by the Sponsor. Analysis: Details of identification ofthe test item will be supplied by the study Sponsor. The test item formulations will be analyzed for concentration and stability byWIL Research Europe, 'sHertogenbosch, the Netherlands. Physical/Chemical Properties To Fulfill Testing Requirements A1to 5 1. Melting point: EC A.1 

### I OECD 102 

### I OPPTS 830.7200 or, if afreezing point: OECD 102 (melting poinUmelting range). 2. Boiling point: EC A.2 

### I OECD 103 

### IOPPTS 830.7220 3. Vapor Pressure: ASTM E 1782-08 (thermal analysis) 4. N-Octanol/water partition coefficient (log 10 basis) or logK0w by appropriate method as specified as Method A, 40 CFR 799.6755 (shake flask); Method B, ASTM E 1147-92 (reapproved 2005) (liquid chromatography); or Method C, 40 CFR 799.6756 (generator column). A test to determine the octanol/water partition coefficient is not required when the estimated log Kow (the log ofthe octanol/water partitioning coefficient) ofthe chemical is < 0. We have determined that the log Kow (also known as the log P) for COPS-1 is< 0. Please referto Attachment A for detailed results ofthe estimation methodology used. 5. Watersolubility: By appropriate test method as specified as Method A, ASTM E 1148- 02 (reapproved 2008) (shakeflask); Method B, 40 CFR 799.6784 (shake flask); Method C, 40 CFR 799.6784 (column elution); or Method D, 40 CFR 799.6786 (generator column).
Environmental Fate and Pathways to Fulfill Testing Requirement B 1. Environmental fate and pathways - ready biodegradation: According to ISO 10634:1995(E)guidance by one ofthe following: 1) ISO 9439:1999(E) (C02 evolution test); or2) ISO 10707:1994(E) (closed bottle test) AquaticToxicity- to Fulfill Testing Requirement C1 as a Test Group 1 Substance Based upon the estimated log Kow (the log ofthe octanol/water partitioning coefficient) ofCOPS-1 being< 4.2 {please referto Attachment A for results). We intend to perform aquatic toxicity Test Group 1 as detailed below; 

# ..1 4•ChemStewards' APROGHAMOFSOCMA**18~0** M St**r·~vV** Si>tt. 700. \!'v'.r,fl,rJgtul1 DC 20036-SBI 0. Tel 202 721 4100. FJ:x 202-296-8120. www SOCi1l:l.COili

### 1. Acute toxicity to fish, ASTM E 729-96 (reapproved 2007)/0PPTS 850.1075. 2. Acute toxicity to Daphnia, ASTM E 729-96 (reapproved 2007)/0PPTS850.1010 3. Toxicity to plants (algae), ASTM E 1218-04e1/0PPTS850.5400 Mammalian toxicity- acute- to Fulfill Testing Requirement D 1. Acute (up/down) oral toxicity (rat), 40 CFR 799.911O(d)(1 )(i)(A). Mammalian Toxicity- GenotoxicityTo Fulfill Testing Requirement E1 and E2 1. Gene Mutations: Bacterial Reverse Mutation Test (in vitro): 40 CFR 799.9510 (OECD471) 

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2. Mammalian (chromosomal damage): In vitro mammalian chromosome aberration, 40 CFR 799.9537 (OECD473) Mammalian Toxicity-Repeated Dose/Reproduction/Developmental to Fulfill Testing Requirement F1 1. Combined repeated dose toxicity study with reproduction/developmental toxicity screening test, 40 CFR 799.9365/0PPTS 870.3650/0ECD422

Initiation ofthe required testing is subjectto Environmental Protection Agency's approval ofthe test plan offered in this letter. In order to begin testing as quickly as possible to help us meet the EPA's reporting deadline, we lookforward to Agency feedback at your earliest opportunity.
Please contact the undersigned directly at202-721-4154 or helmest@socma.com for questions oradditional information.

Attachments: Sincerely,

C. Tucker Helmes, Ph.D. Executive Director

A) Rationale forwaiving octanol/water partition coefficient testing for 1-Propanesulfonic acid, 2-hydroxy-3-(2-propenyloxy)-, monosodium salt (CASRN: 52556-42-0)

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.PROGKAM OfSOCMA 18)0 M St NW

### s,, tc 700 •Wao,h,ngtol1 DC 20036-58 l0 • 1 cl 202-72 I-4100 • Fax 202 296 8120 • NWW SO(nn com

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ATTACHMENT A Rationaleforwaiving octanol/water partition coefficienttesting for 1-Propanesulfonic acid, 2-hydroxy-3-(2-propenyloxy)-, monosodium salt (CASRN: 52556-42-0) Summary Perthe EPAtest rule for Certain High Production Volume Chemicals (Third Group of Chemicals), 1the proposed tests for 1-Propanesulfonicacid, 2-hydroxy-3-(2-propenyloxy)-, monosodium salt (COPS-1) include determining the octanol/water partition coefficient (Test Category: Physical/Chemical Properties). However, a testto determine the octanol/water partition coefficient is not required when the estimated log Kow (the log ofthe octanol/water partitioning coefficient) ofthe chemical is < 0. We have determined that the log Kow (also known as the log P) for COPS-1 is< 0. Rationale EPA recommends thatthe octanol/water partition coefficient be estimated priorto initiating the proposed studies. One estimation method recommended by EPA1 is the application ofthe socalled atom/fragment contribution method as described by Meylan and Howard.2 This estimation methodology is incorporated into the computer program KOWWIN. KOWWIN (the Log Octanoi-Water Partition Coefficient Program) estimates the logarithmic octanol-water partition coefficient (log P) oforganic compounds based on the molecular structure ofthe compound. Per KOWWIN (v 1.67), the estimated log Kow for COPS-1 is -5.00 (model results provided below). Thus, based on this estimate, and according to the criteria provided in the test rule, 1we believe that conducting a test to determine the octanol/water partition coefficient for COPS-1 is not required. Log Kow(version .:..67 esti:nate): -5.00 SMILES : S(=O) (=0) (O:Na])CC(O)COCC=C CHEM**1-Propa~esu.:.fonic** acid, 2-hydroxy-3-(2-propenyloxy)-,**mo~osodium** salt MOL FOR: CE H11 05 

### s.:. Na1 MOL WT : 218.20**-------~-----+--------------------------------------------+---------+--------**

TYPE**~~JM** I LOGKOW FRAGMENT DESCR:PTION I COEFF I VALUE -------+-----+--------------------------------------------+---------+--------

Frag 3 I -CH:> [aliphatic carbon] I 0.4911 I 1.4733 Frag 1 I -CH [aliphatic carbon] I 0.3614 I 0.3614 Frag 1 I =CH2 [olefinic carbon] I 0.5184 I 0.52.84 Frag 1 I =CH- or =C< :olefine**carbo~]** I 0.3836 I 0.3836 Frag 1 I -OH [hydroxy, aliphatic attach] 1-1.4086 I -1.4086 Frag 1 I -0- [oxygen, a.:.iphatic attach] 1-1.2566 I -1.2566 Frag 1 I -502-0 [sulfonate, aliph att] 1-0.7250 I -0.7250 Factor 1 I**S-0-~Na,K,Li}** [coef*(1+0.3*(NUM-1))] 1-4.5800 I -4.5800 Const I Equation Constant I I 0.2290 -------+-----+--------------------------------------------+---------+-------- Log Kow -5.0045

1Federal Register IVol. 75, No. 37 IThursday, February 25, 2010 IProposed Rules. 2Meylan, W.M. and Howard, P.H. Atom/FragmentContribution MethodforEstimating Octanoi-WaterPartition Coefficients. Journal ofPharmaceutical Sciences. Vol. 84(1):83-92. 1995

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./. ChemStewa<ds' APRoGRAM orSOCMA 1850 MSt N\'V Su rc 700 •W,J<,h,ngtorL DC 20036- )81 0 •Tel 202 721-4100 • F;;x 202 296-8120 • www.socnn.ccrn