EX-10.6





 Exhibit 10.6 

Execution Version 

REGISTRATION RIGHTS AGREEMENT 

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of September 2, 2021 (the “Effective
Date”), is made and entered into by and among Renovacor, Inc., a Delaware corporation (f/k/a Chardan Healthcare Acquisition 2 Corp.) (the “Company”), and each of the stockholders set forth on the signature pages hereto
(each, a “Stockholder” collectively, the “Stockholders”). 
 WHEREAS, on the Effective Date,
certain Stockholders identified as the “Initial Stockholders” on Exhibit A hereto (the “Initial Stockholders”) collectively hold 2,155,661 shares of Common Stock (the “Initial Shares”) and warrants
exercisable for 3,500,000 shares of Common Stock (the “Initial Warrants”), which were issued to the Initial Stockholders prior to the consummation of the Company’s initial public offering; 

WHEREAS, on the Effective Date, certain of the Stockholders identified as the “Renovacor Stockholders” on Exhibit A
hereto (the “Renovacor Stockholders”) have acquired an aggregate of 6,500,000 shares of Common Stock (together with any shares of Common Stock that may be issued to the Renovacor Stockholders as Earnout Consideration (as defined in
the Merger Agreement), if any, collectively, the “Merger Shares”) in connection with the consummation of the transactions contemplated by that certain Agreement and Plan of Merger (the “Merger Agreement”), dated as
of March 22, 2021, by and among the Company, CHAQ2 Merger Sub, Inc., a Delaware corporation and wholly owned subsidiary of the Company (“Merger Sub”), and Renovacor Holdings, Inc. (f/k/a Renovacor, Inc.) (the “Acquired
Company”), pursuant to which Merger Sub merged with and into the Acquired Company (the “Merger”), with the Acquired Company surviving the Merger as a wholly owned subsidiary of the Company; and 

WHEREAS, pursuant to the terms of the Merger Agreement and the Subscription Agreements, the Company has agreed to register (i) the
Initial Shares and all shares of Common Stock issuable pursuant to the exercise of the Initial Warrants, (ii) the Merger Shares and (iii) the Investment Shares for resale under the 1934 Act, and the Stockholders and the Company desire to
enter into this Agreement to provide the Stockholders with certain rights relating to the registration of such securities from time to time after the Effective Date. 

NOW, THEREFORE, IN CONSIDERATION of the mutual covenants and agreements set forth herein, and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree as follows: 

1. CERTAIN DEFINITIONS. As used in this Agreement, the following capitalized terms used herein shall have the following meanings: 

“1933 Act” means the Securities Act of 1933, as amended. 

“1934 Act” means the Securities and Exchange Act of 1934, as amended. 

“Acquired Company” has the meaning set forth in the Recitals. 

“Agreement” has the meaning set forth in the Preamble. 

“Allowed Delay” has the meaning set forth in Section 2(c)(ii). 

“Availability Date” has the meaning set forth in Section 3(i). 












 “Block Trade” means an offering and/or sale of Registrable Securities by
any Stockholder on a block trade or underwritten basis (whether firm commitment or otherwise) without substantial marketing efforts prior to pricing, including, without limitation, a same day trade, overnight trade or similar transaction. 

“Business Day” means any day other than Saturday, Sunday or other day on which commercial banks in the City of New York are
authorized or required by law to remain closed. 
 “Common Stock” means the Company’s common stock, par value $0.0001
per share. 
 “Company” has the meaning set forth in the Preamble. 

“Cut Back Shares” has the meaning set forth in Section 2(d). 

“Demand Registration” has the meaning set forth in Section 2(e)(i). 

“Demanding Holders” has the meaning set forth in Section 2(e)(i). 

“Demand Requesting Holder” has the meaning set forth in Section 2(e)(i). 

“Effective Date” has the meaning set forth in the Preamble. 

“Effectiveness Period” has the meaning set forth in Section 3(a). 

“Filing Deadline” has the meaning set forth in Section 2(a)(i). 

“Indemnified Party” has the meaning set forth in Section 5(c). 

“Indemnifying Party” has the meaning set forth in Section 5(c). 

“Initial Registration Statement” has the meaning set forth in Section 2(a)(i). 

“Initial Shares” has the meaning set forth in the Recitals. 

“Initial Stockholders” has the meaning set forth in the Recitals. 

“Investment Shares” has the meaning set forth in the Recitals. 

“Initial Warrants” has the meaning set forth in the Recitals. 

“Losses” has the meaning set forth in Section 5(a). 

“Maximum Number of Shares” has the meaning set forth in Section 2(e)(v). 

“Merger” has the meaning set forth in the Recitals. 

“Merger Agreement” has the meaning set forth in the Recitals. 

“Merger Shares” has the meaning set forth in the Recitals. 

“Merger Sub” has the meaning set forth in the Recitals. 

  
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 “Misstatement” has the meaning set forth in Section 3(h). 

“Piggy-Back Registration” has the meaning set forth in Section 2(f)(i). 

“Prospectus” means (i) the prospectus included in any Registration Statement, as amended or supplemented by any
prospectus supplement, with respect to the terms of the offering of any portion of the Registrable Securities covered by such Registration Statement and by all other amendments and supplements to the prospectus, including post-effective amendments
and all material incorporated by reference in such prospectus, and (ii) any “free writing prospectus” as defined in Rule 405 under the 1933 Act. 

“Register,” “registered” and “registration” refer to a registration made by preparing and
filing a Registration Statement or similar document in compliance with the 1933 Act (as defined below), and the declaration or ordering of effectiveness of such Registration Statement or document. 

“Registrable Securities” means (i) the Initial Shares, the Merger Shares and the Investment Shares and (ii) any
shares of Common Stock that are issued pursuant to the exercise of the Initial Warrants and any other securities issued or issuable with respect to or in exchange for Initial Shares, Merger Shares or Investment Shares; provided, that, such
securities shall cease to be Registrable Securities when (i) a Registration Statement with respect to the sale of such securities shall have become effective under the Securities Act and such securities shall have been sold, transferred,
disposed of or exchanged in accordance with such Registration Statement; (ii) such securities shall have been otherwise transferred, new certificates or book entry positions for such securities not bearing a legend restricting further transfer
shall have been delivered by the Company and subsequent public distribution of such securities shall not require registration under the Securities Act; (iii) such securities shall have ceased to be outstanding; (iv) such securities have
been sold to, or through, a broker, dealer or underwriter in a public distribution or other public securities transaction; or (v) with respect to a Stockholder, when all such securities held by such Stockholder could be sold without restriction
on volume or manner of sale in any three-month period without registration under Rule 144 promulgated under the Securities Act (or any successor rule promulgated thereafter by the Commission). 

“Registration Statement” means any registration statement filed by the Company under the 1933 Act and the rules and
regulations promulgated thereunder that covers the resale of any of the Registrable Securities pursuant to the provisions of this Agreement, amendments and supplements to such Registration Statement, including post-effective amendments, and all
exhibits to and all material incorporated by reference in such Registration Statement. 
 “Renovacor Stockholders” has the
meaning set forth in the Recitals. 
 “Required Stockholders” means the Stockholders holding a majority of the Registrable
Securities outstanding from time to time. 
 “Restriction Termination Date” has the meaning set forth in Section 2(d).

 “Rule 144” means Rule 144 promulgated by the SEC pursuant to the 1933 Act, as such rule may be amended from time to
time, or any similar rule or regulation hereafter adopted by the SEC having substantially the same effect as such rule. 
 “Rule
415” has the meaning set forth in Section 2(a)(i). 
 “SEC” means the U.S. Securities and Exchange
Commission. 

  
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 “SEC Restrictions” has the meaning set forth in Section 2(d). 

“Selling Stockholder” means any Stockholder electing to sell any of its Registrable Securities in a Registration. 

“Selling Stockholder Questionnaire” means a questionnaire in the form attached as Exhibit B hereto, or such other form
of questionnaire as may reasonably be adopted by the Company from time to time. 
 “Stockholder” has the meaning set forth
in the Preamble. 
 “Stockholder Indemnified Party” has the meaning set forth in Section 5(a). 

“Subscription Agreements” has the meaning set forth in the Recitals. 

“Trading Day” means a day on which the Common Stock is listed or quoted and traded on the NYSE American. 

“Underwriter” means a securities dealer who purchases any Registrable Securities as principal in an Underwritten Offering and
not as part of such dealer’s market-making activities. 
 “Underwritten Offering” has the meaning set forth in
Section 2(e)(iii). 
 “Underwritten Shelf Takedown” has the meaning set forth in Section 2(e)(iv). 

2. REGISTRATION RIGHTS. 
 (a)
Registration Statements. 
 (i) Promptly following the Effective Date but no later than forty-five (45) days after the Effective
Date (the “Filing Deadline”), the Company shall prepare and file with the SEC a Registration Statement covering the resale of all of the Registrable Securities for an offering to be made on a continuous basis pursuant to Rule 415
promulgated under the 1933 Act (“Rule 415”) or, if Rule 415 is not available for offers and sales of the Registrable Securities, by such other means of distribution of Registrable Securities as the Stockholders may reasonably
specify (the “Initial Registration Statement”). The Initial Registration Statement shall be on Form S-1 and shall contain (except if otherwise required pursuant to written comments received
from the SEC upon review of such Registration Statement) a “Plan of Distribution” substantially in the form attached hereto as Exhibit B (which may be modified to respond to comments, if any, provided by the SEC); provided,
however, that no Stockholder shall be named as an Underwriter in such Registration Statement without the Stockholder’s prior written consent. The Company shall use commercially reasonable efforts to convert or replace the Initial
Registration Statement with a Registration Statement on Form S-3 promptly following confirmation that the Company becomes eligible to use Form S-3 to register the
Registrable Securities. 
 (ii) Such Registration Statement also shall cover, to the extent allowable under the 1933 Act and the rules
promulgated thereunder (including Rule 416), such indeterminate number of additional shares of Common Stock resulting from stock splits, stock combinations, stock dividends or similar transactions with respect to the Registrable Securities. Such
Registration Statement (and each amendment or supplement thereto, and each request for acceleration of effectiveness thereof) shall be provided in accordance with Section 3(c) to the Stockholders prior to its filing or
other submission. 

  
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 (b) Expenses. The Company will pay all expenses associated with each Registration
Statement, including filing and printing fees, the fees and expenses of the Company’s counsel and accounting fees and expenses, costs associated with clearing the Registrable Securities for sale under applicable state securities laws and
listing fees, but excluding discounts, commissions, fees of underwriters, selling brokers, dealer managers or similar securities industry professionals with respect to the Registrable Securities being sold. 

(c) Effectiveness. 
 (i)
The Company shall use commercially reasonable efforts to have each Registration Statement declared effective as soon as practicable after the filing. The Company shall notify the Stockholders as promptly as practicable after the Registration
Statement is declared effective and shall simultaneously or prior thereto file with the SEC pursuant to Rule 424(b) promulgated under the 1933 Act, and provide the Stockholders with copies of, any related Prospectus to be used in connection with the
sale or other disposition of the securities covered thereby. 
 (ii) For not more than ninety (90) consecutive days or for a total of
not more than one-hundred twenty (120) days in any twelve (12) month period, the Company may suspend the use of any Prospectus included in any Registration Statement contemplated by this
Section 2 in the event that the Company determines in good faith that such suspension is necessary to (A) delay the disclosure of material non-public information concerning the
Company, the disclosure of which at the time is not, in the good faith opinion of the Company, in the best interests of the Company or (B) amend or supplement the affected Registration Statement or the related Prospectus so that such
Registration Statement or Prospectus shall not include any Misstatement (an “Allowed Delay”); provided, that the Company shall promptly (1) notify each Stockholder in writing of the commencement of an Allowed Delay, but
shall not (without the prior written consent of a Stockholder) disclose to such Stockholder any material non-public information giving rise to an Allowed Delay, (2) advise the Stockholders in writing to
cease all sales under such Registration Statement until the end of the Allowed Delay (but not, for the avoidance of doubt, any sale pursuant to Rule 144 or other applicable exemption under the 1933 Act) and (3) use commercially reasonable
efforts to terminate an Allowed Delay as promptly as practicable. 
 (d) Rule 415; Cutback. If at any time the SEC
takes the position that the offering of some or all of the Registrable Securities in a Registration Statement is not eligible to be made on a delayed or continuous basis under the provisions of Rule 415 or requires any Stockholder to be named as an
Underwriter, the Company shall use commercially reasonable efforts to persuade the SEC that the offering contemplated by such Registration Statement is a valid secondary offering and not an offering “by or on behalf of the issuer” as
defined in Rule 415 and that none of the Stockholders is an Underwriter. The Stockholders shall have the right to select one legal counsel to review and oversee any registration or matters pursuant to this
Section 2(d), including participation in any meetings or discussions with the SEC regarding the SEC’s position and to comment on any written submission made to the SEC with respect thereto, which counsel
shall be designated by the Required Holders. No such written submission with respect to this matter shall be made to the SEC to which such counsel so designated by the Required Holders reasonably objects. In the event that, despite the
Company’s commercially reasonable efforts and compliance with the terms of this Section 2(d), the SEC refuses to alter its position, the Company shall (i) remove from such Registration Statement such
portion of the Registrable Securities (the “Cut Back Shares”) and/or (ii) agree to such restrictions and limitations on the registration and resale of the Registrable Securities as the SEC may require to assure the
Company’s compliance with the requirements of Rule 415 (collectively, the “SEC Restrictions”); provided, however, that the Company shall not agree to name any Stockholder as an Underwriter in such Registration
Statement without the prior written consent of such Stockholder. Any cut-back imposed on the Stockholders pursuant to this Section 2(d) shall be allocated among the
Stockholders on a pro rata basis and shall be applied first to any of the Registrable Securities of 

  
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such Stockholder as such Stockholder shall designate, unless the SEC Restrictions otherwise require or provide or the Required Stockholders otherwise agree. From and after the first date on which
the Company is able to effect the registration of such Cut Back Shares (such date, the “Restriction Termination Date”), all of the provisions of this Section 2 (including the Company’s obligations with
respect to the filing of a Registration Statement and its obligations to use commercially reasonable efforts to have such Registration Statement declared effective within the time periods set forth herein) shall again be applicable to such Cut Back
Shares; provided, however, that (i) the Filing Deadline for such Registration Statement including such Cut Back Shares shall be ten (10) Business Days after the Restriction Termination Date, and (ii) the date by which
the Company is required to obtain effectiveness with respect to such Cut Back Shares under Section 2(c) shall be the 30th day immediately after the Restriction Termination Date (or the 90th day if the SEC reviews
such Registration Statement).
 (e) Demand Registration. 

(i) Request for Registration. At any time and from time to time when there is no valid Registration Statement in effect, the Required
Stockholders (the “Demanding Holders”) may make a written demand for registration under the 1933 Act of all or part of their Registrable Securities (a “Demand Registration”). Any demand for a Demand Registration
shall specify the number of Registrable Securities proposed to be sold and the intended method(s) of distribution thereof. The Company will within twenty (20) days of the Company’s receipt of the Demand Registration notify all holders of
Registrable Securities of the demand, and each holder of Registrable Securities who wishes to include all or a portion of such holder’s Registrable Securities in the Demand Registration (each, a “Demand Requesting Holder”)
shall so notify the Company within five (5) days after the receipt by the holder of the notice from the Company. Upon any such request, the Demanding Holders and the Demand Requesting Holders shall be entitled to have their Registrable
Securities included in the Demand Registration, subject to Section 2(e)(v) and Section 2(d), to be effected by the Company as soon as reasonably practicable, but in no event later than sixty (60) days after receipt of such Demand
Registration. The Company shall not be obligated to effect more than an aggregate of two (2) Demand Registrations under this Section 2(e). 

(ii) Effective Registration. A Registration will not count as a Demand Registration until the Registration Statement filed with the
Commission with respect to such Demand Registration has been declared effective and the Company has complied with all of its obligations under this Agreement with respect thereto; provided, however, that if, after such Registration
Statement has been declared effective, the offering of Registrable Securities pursuant to a Demand Registration is interfered with by any stop order or injunction of the Commission or any other governmental agency or court, the Registration
Statement with respect to such Demand Registration will be deemed not to have been declared effective, unless and until (a) such stop order or injunction is removed, rescinded or otherwise terminated, and (b) a majority-in-interest of the Demanding Holders who initiated such Demand Registration thereafter affirmatively elect to continue the offering and notify the Company thereof in
writing, but in no event later than five (5) days of such election; provided, further, that the Company shall not be obligated or required to file another Registration Statement until the Registration Statement that has been previously
filed with respect to a Registration pursuant to a Demand Registration becomes effective or is subsequently terminated. 
 (iii)
Underwritten Offering. If a majority-in-interest of the Demanding Holders who initiate a Demand Registration so elect and such holders so advise the Company as
part of their written demand for a Demand Registration, the offering of such Registrable Securities pursuant to such Demand Registration shall be in the form of an underwritten offering (which, for the avoidance of doubt, may be an underwritten
Block Trade) (an “Underwritten Offering”); provided that the Company shall only be obligated to effect an Underwritten Offering if such Underwritten Offering shall include Registrable Securities proposed to be sold by the
Demanding Holders, either individually or together with other 

  
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Demanding Holders, with a total offering price reasonably expected to exceed, in the aggregate, $25 million. In such event, the right of any holder to include its Registrable Securities in
such Registration shall be conditioned upon such holder’s participation in such Underwritten Offering and the inclusion of such holder’s Registrable Securities in the Underwritten Offering to the extent provided herein. All Demanding
Holders proposing to distribute their securities through such Underwritten Offering shall enter into an underwriting agreement in reasonable and customary form with the Underwriter or Underwriters selected for such Underwritten Offering by a majority-in-interest of the holders initiating the Demand Registration. 

(iv) Requests for Underwritten Shelf Takedowns. Subject to Section 2(c), at any time and from time to time when a valid
Registration Statement is then in effect, the Demanding Holders may request to sell all or any portion of their Registrable Securities in an Underwritten Offering that is registered pursuant to the applicable Registration Statement (each, an
“Underwritten Shelf Takedown”); provided that the Company shall only be obligated to effect an Underwritten Shelf Takedown if such Underwritten Shelf Takedown shall include Registrable Securities proposed to be sold by the
Demanding Holders, either individually or together with other Demanding Holders, with a total offering price reasonably expected to exceed, in the aggregate, $25 million, but in no event less than $10 million in aggregate gross proceeds.
All requests for Underwritten Shelf Takedowns shall be made by giving written notice to the Company, which shall specify the approximate number of Registrable Securities proposed to be sold in the Underwritten Shelf Takedown. The Company shall have
the right to select the Underwriters for such Underwritten Offering (which shall consist of one or more reputable nationally recognized investment banks). The Company shall not be obligated to effect more than an aggregate of one
(1) Underwritten Shelf Take-Down in any twelve (12) month period. Notwithstanding anything to the contrary in this Agreement, the Company may effect any Underwritten Offering pursuant to any then effective Registration Statement, including
a Form S-3, that is then available for such Underwritten Offering. 
 (v) Reduction of
Offering. If the managing Underwriter or Underwriters for a Demand Registration that is to be an Underwritten Offering, in good faith, advises the Company, the Demanding Holders and the Demand Requesting Holders that the dollar amount or number
of shares of Registrable Securities which the Demanding Holders and Demand Requesting Holders (if any) desire to sell, taken together with all other shares of Common Stock or other securities which the Company desires to sell and the shares of
Common Stock, if any, as to which Underwritten Offering has been requested pursuant to registration rights held by other stockholders of the Company who desire to sell, exceeds the maximum dollar amount or maximum number of shares that can be sold
in such Underwritten Offering without adversely affecting the proposed offering price, the timing, the distribution method, or the probability of success of such offering (such maximum dollar amount or maximum number of shares, as applicable, the
“Maximum Number of Shares”), then the Company shall include in such Underwritten Offering: (i) the Registrable Securities as to which Demand Registration or Underwritten Shelf Takedown has been requested by the Demanding
Holders and Demand Requesting Holders (if any) on a pro rata basis that can be sold without exceeding the Maximum Number of Shares; (ii) to the extent that the Maximum Number of Shares has not been reached under the foregoing clause (i), the
shares of Common Stock or other securities that the Company desires to sell that can be sold without exceeding the Maximum Number of Shares and (iii) to the extent that the Maximum Number of Shares have not been reached under the foregoing
clauses (i) and (ii), the shares of Common Stock or other securities for the account of other persons that the Company is obligated to Register pursuant to written contractual arrangements with such persons and that can be sold without
exceeding the Maximum Number of Shares. 
 (f) Piggy-Back Registration. 

(i) Piggy-Back Rights. If at any time from time to time when there is no valid Registration Statement in effect, the Company proposes
to file a Registration Statement under the 1933 Act with respect to an offering of equity securities, or securities or other obligations exercisable or exchangeable 

  
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for, or convertible into, equity securities, by the Company for its own account or for stockholders of the Company for their account (or by the Company and by stockholders of the Company
including, without limitation, pursuant to Section 2(e)), other than a Registration Statement (i) filed in connection with any employee stock option or other benefit plan, (ii) for an exchange offer or offering of securities solely to
the Company’s existing stockholders, (iii) for an offering solely of debt that is convertible into equity securities of the Company or (iv) for a dividend reinvestment plan, then the Company shall (x) give written notice of such
proposed filing to the holders of Registrable Securities as soon as practicable but in no event less than five (5) days before the anticipated filing date, which notice shall describe the amount and type of securities to be included in such
offering, the intended method(s) of distribution, and the name of the proposed managing Underwriter or Underwriters, if any, of the offering, and (y) offer to the holders of Registrable Securities in such notice the opportunity to Register the
sale of such number of shares of Registrable Securities as such holders may request in writing within five (5) days following receipt of such notice (a “Piggy-Back Registration”). The Company shall, in good faith, cause such
Registrable Securities to be included in such Registration and shall use its commercially reasonable efforts to cause the managing Underwriter or Underwriters of a proposed Underwritten Offering to permit the Registrable Securities requested to be
included in a Piggy-Back Registration on the same terms and conditions as any similar securities of the Company and to permit the sale or other disposition of such Registrable Securities in accordance with the intended method(s) of distribution
thereof. All holders of Registrable Securities proposing to distribute their securities through a Piggy-Back Registration that involves an Underwriter or Underwriters shall enter into an underwriting agreement in reasonable and customary form with
the Underwriter or Underwriters selected for such Piggy-Back Registration; provided, that no Stockholder including Registrable Securities in any Underwritten Offering shall be required to make any representations or warranties to the Company
or the Underwriters, other than representations and warranties regarding such Stockholder or such Stockholder’s ownership of its Registrable Securities to be sold in the offering or to undertake any indemnification obligations to the Company or
the Underwriters with respect thereto except to the extent expressly set forth in Section 5(b) hereof. 
 (ii) Reduction of
Offering. If the managing Underwriter or Underwriters for a Piggy-Back Registration that is to be an Underwritten Offering advises the Company and the Holders of Registrable Securities that the dollar amount or number of shares of Common Stock
which the Company desires to sell, taken together with shares of Common Stock, if any, as to which such Underwritten Offering has been demanded pursuant to separate written contractual arrangements with persons or entities other than the Holders of
Registrable Securities hereunder, the Registrable Securities as to which such Underwritten Offering has been requested under this Section 2(f), and the shares of Common Stock, if any, as to which such Underwritten Offering has been requested
pursuant to the written contractual piggy-back registration rights of other stockholders of the Company, exceeds the Maximum Number of Shares, then the Company shall include in any such Underwritten Offering: 

(1) If the Registration is undertaken for the Company’s account: (A) the shares of Common Stock or other securities that the
Company desires to sell for its own account that can be sold without exceeding the Maximum Number of Shares; (B) to the extent that the Maximum Number of Shares has not been reached under the foregoing clause (A), the shares of Common Stock or
other securities, if any, comprised of Registrable Securities, as to which Registration has been requested pursuant to the applicable written contractual Piggy-Back Registration rights of the Stockholders pursuant to Section 2(f)(i), on a pro
rata basis, that can be sold without exceeding the Maximum Number of Shares; and (C) to the extent that the Maximum Number of Shares has not been reached under the foregoing clauses (A), (B) and (C), the shares of Common Stock or other
securities for the account of other persons that the Company is obligated to Register pursuant to written contractual piggy-back registration rights with such persons and that can be sold without exceeding the Maximum Number of Shares; and 

  
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 (2) If the Registration is a “demand” registration undertaken at the demand of
persons or entities other than the holders of Registrable Securities, (A) the shares of Common Stock or other securities for the account of the demanding persons that can be sold without exceeding the Maximum Number of Shares; (B) to the
extent that the Maximum Number of Shares has not been reached under the foregoing clause (A), the shares of Common Stock or other securities, if any, comprised of Registrable Securities, as to which Registration has been requested pursuant to the
applicable written contractual Piggy-Back Registration rights of Holders under Section 2(f)(i), on a pro rata basis, that can be sold without exceeding the Maximum Number of Shares; (C) to the extent that the Maximum Number of Shares has
not been reached under the foregoing clauses (A) and (B), the shares of Common Stock or other securities that the Company desires to sell for its own account that can be sold without exceeding the Maximum Number of Shares; and (D) to the
extent that the Maximum Number of Shares has not been reached under the foregoing clauses (A), (B) and (C), the shares of Common Stock or other securities for the account of other persons that the Company is obligated to Register pursuant to written
contractual arrangements with such persons, that can be sold without exceeding the Maximum Number of Shares. 
 (iii) Unlimited
Piggy-Back Registration Rights. For purposes of clarity, any Registration effected pursuant to this Section 2(f) shall not be counted as a Registration pursuant to a Demand Registration effected under Section 2(e) hereof. 

3. COMPANY OBLIGATIONS. The Company will use commercially reasonable efforts to effect the registration of the Registrable Securities in accordance
with the terms hereof, and pursuant thereto the Company will, as expeditiously as possible: 
 (a) use commercially reasonable efforts to
cause such Registration Statement to become effective and to remain continuously effective for a period that will terminate upon the date on which all Registrable Securities covered by such Registration Statement may be sold without restriction or
limitation pursuant to Rule 144 and without the requirement to be in compliance with Rule 144(c)(1) during any ninety (90) day period (the “Effectiveness Period”) and advise the Stockholders promptly in writing when the
Effectiveness Period has expired; 
 (b) prepare and file with the SEC such amendments and post-effective amendments to such Registration
Statement and the related Prospectus as may be necessary to keep such Registration Statement effective for the Effectiveness Period and to comply with the provisions of the 1933 Act and the 1934 Act with respect to the distribution of all of the
Registrable Securities covered thereby; 
 (c) provide copies to and permit the Stockholders to review each Registration Statement and all
amendments and supplements thereto not less than five (5) Trading Days prior to the filing of each Registration Statement and not less than one (1) Trading Day prior to the filing of any related Prospectus or any amendment or supplement
thereto (except for Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K and any similar
or successor reports) and provide the Stockholders a reasonable opportunity to comment thereon, and the Company shall consider such comments in good faith before filing any Registration Statement or amendment or supplement thereto; 

(d) furnish to each Stockholder whose Registrable Securities are included in any Registration Statement (i) promptly after the same is
prepared and filed with the SEC, if requested by the Stockholder, one (1) copy of any Registration Statement and any amendment thereto (provided, that the Company shall have no obligation to provide any document pursuant to this clause
that is available on the SEC’s EDGAR system), each preliminary prospectus and Prospectus and each amendment or supplement thereto, and (ii) such number of copies of a Prospectus, including a preliminary prospectus, and all amendments and
supplements thereto and such other documents as each Stockholder may reasonably request in order to facilitate the disposition of the Registrable Securities owned by such Stockholder that are covered by such Registration Statement; 

  
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 (e) use commercially reasonable efforts to (i) prevent the issuance of any stop order
or other suspension of effectiveness and (ii) if such order is issued, obtain the withdrawal of any such order at the earliest practical moment; 

(f) prior to any public offering of Registrable Securities, use commercially reasonable efforts to register or qualify or cooperate with the
Stockholders and their counsel in connection with the registration or qualification of such Registrable Securities for the offer and sale under the securities or blue sky laws of such jurisdictions requested by the Stockholders and do any and all
other commercially reasonable acts or things necessary or advisable to enable the distribution in such jurisdictions of the Registrable Securities covered by the Registration Statement; provided, however, that the Company shall not be
required in connection therewith or as a condition thereto to (i) qualify to do business in any jurisdiction where it would not otherwise be required to qualify but for this Section 3(f), (ii) subject itself to
general taxation in any jurisdiction where it would not otherwise be so subject but for this Section 3(f), or (iii) file a general consent to service of process in any such jurisdiction; 

(g) use commercially reasonable efforts to cause all Registrable Securities covered by a Registration Statement to be listed on each
securities exchange or other market on which similar securities issued by the Company are then listed or quoted; 
 (h) promptly notify the
Stockholders, at any time prior to the end of the Effectiveness Period, upon discovery that, or upon the happening of any event as a result of which, the Prospectus includes an untrue statement of a material fact or omits to state any material fact
required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing (a “Misstatement”), and promptly prepare, file with the SEC and furnish to such holder a supplement
to or an amendment of such Prospectus as may be necessary so that such Prospectus shall not include such Misstatement; and 
 (i) otherwise
use commercially reasonable efforts to comply with all applicable rules and regulations of the SEC under the 1933 Act and the 1934 Act, including, without limitation, Rule 172 under the 1933 Act, file any final Prospectus, including any supplement
or amendment thereof, with the SEC pursuant to Rule 424 under the 1933 Act, promptly inform the Stockholders in writing if, at any time during the Effectiveness Period, the Company does not satisfy the conditions specified in Rule 172 and, as a
result thereof, the Stockholders are required to deliver a Prospectus in connection with any disposition of Registrable Securities and take such other actions as may be reasonably necessary to facilitate the registration of the Registrable
Securities hereunder; and make available to its security holders, as soon as reasonably practicable, but not later than the Availability Date (as defined below), an earnings statement covering a period of at least twelve (12) months, beginning
after the effective date of each Registration Statement, which earnings statement shall satisfy the provisions of Section 11(a) of the 1933 Act, including Rule 158 promulgated thereunder (for the purpose of this
Section 3(i), “Availability Date” means the 45th day following the end of the fourth fiscal quarter that includes the effective date of such Registration Statement, except that, if such fourth fiscal
quarter is the last quarter of the Company’s fiscal year, “Availability Date” means the 90th day after the end of such fourth fiscal quarter). 

With a view to making available to the Stockholders the benefits of Rule 144 and any other rule or regulation of the SEC that may at any time permit the
Stockholders to sell shares of Common Stock to the public without registration, the Company covenants and agrees to: (i) make and keep public information available, as those terms are understood and defined in Rule 144, until the earlier of
(A) six (6) months after such date as all of the Registrable Securities may be sold without restriction by the holders thereof pursuant 

  
 -10- 













 
to Rule 144 or any other rule of similar effect or (B) such date as all of the Registrable Securities shall have been resold pursuant to a Registration Statement or Rule 144; (ii) file with
the SEC in a timely manner all reports and other documents required of the Company under the 1934 Act; (iii) prior to the filing of any Registration Statement or any amendment thereto (whether
pre-effective or post-effective) and prior to the filing of any Prospectus, provide to each Stockholder copies of all pages thereof (if any) that reference such Stockholders, and (iv) furnish to each
Stockholder upon request, as long as such Stockholder owns any Registrable Securities, (A) a written statement by the Company that it has complied with the reporting requirements of the 1934 Act, (B) a copy of the Company’s most
recent Annual Report on Form 10-K or Quarterly Report on Form 10-Q, and (C) such other information as may be reasonably requested in order to avail such Stockholder
of any rule or regulation of the SEC that permits the selling of any such Registrable Securities without registration. 
 4. OBLIGATION OF THE
INVESTORS. 
 (a) Each Stockholder agrees to furnish to the Company a completed Selling Stockholder Questionnaire within ten
(10) Trading Days after the Effective Date. At least ten (10) Trading Days prior to the first anticipated filing date of a Registration Statement for any registration under this Agreement, the Company will notify each Stockholder of the
information the Company reasonably requires from that Stockholder regarding itself, the Registrable Securities held by it and the intended method of disposition of the Registrable Securities held by it, other than the information contained in the
Selling Stockholder Questionnaire, if any. Each Stockholder shall furnish such information to the Company in writing promptly upon receiving such notification and, in any event, at least three (3) Trading Days prior to the applicable
anticipated filing date (unless such Stockholder has notified the Company in writing of its election to exclude all of its Registrable Securities from such Registration Statement) and shall execute such documents in connection with such registration
as the Company may reasonably request. Each Stockholder further agrees that it shall not be entitled to be named as a selling securityholder in the Registration Statement or use the Prospectus for offers and resales of Registrable Securities at any
time, unless such Stockholder has returned to the Company a completed and signed Selling Stockholder Questionnaire and a response to any reasonable requests for further information as described in the previous sentence. If a Stockholder returns a
Selling Stockholder Questionnaire or a request for further information, in either case, after its respective deadline, the Company shall use its reasonable best efforts to take such actions as are required to name such Stockholder as a selling
security holder in the Registration Statement or any pre-effective or post-effective amendment thereto and to include (to the extent not theretofore included) in the Registration Statement the Registrable
Securities identified in such late Selling Stockholder Questionnaire or request for further information. Each Stockholder acknowledges and agrees that the information in the Selling Stockholder Questionnaire or request for further information as
described in this Section 4(a) will be used by the Company in the preparation of the Registration Statement and hereby consents to the inclusion of such information in the Registration Statement. 

(b) Each Stockholder, by its acceptance of the Registrable Securities, agrees to cooperate with the Company as reasonably requested by the
Company in connection with the preparation and filing of a Registration Statement or in connection with any Underwritten Offering hereunder, unless such Stockholder has notified the Company in writing of its election to exclude all of its
Registrable Securities from such Registration Statement or such Underwritten Offering. 
 (c) Each Stockholder agrees that, upon receipt of
any notice from the Company of either (i) the commencement of an Allowed Delay pursuant to Section 2(c)(i) or (ii) the happening of an event pursuant to Section 3(h) hereof, such
Stockholder will immediately discontinue disposition of Registrable Securities pursuant to any Registration Statement covering such Registrable Securities (but not, for the avoidance of doubt, pursuant to Rule 144 or other applicable exemption under
the 1933 Act), until the Stockholder is advised by the Company that such dispositions may again be made pursuant to such Registration Statement. 

  
 -11- 













 (d) Each Investor covenants and agrees that it will comply with the prospectus delivery
requirements of the 1933 Act as applicable to it or an exemption therefrom in connection with sales of Registrable Securities pursuant to any Registration Statement. 

5. INDEMNIFICATION. 
 (a) (a)
Indemnification by the Company. The Company agrees to indemnify and hold harmless each Stockholder, and each of its officers, employees, Affiliates, directors, partners, members, managers, equityholders, attorneys, advisors and agents, and
each person or entity, if any, who controls (within the meaning of Section 15 of the 1933 Act or Section 20 of the 1934 Act) each Stockholder (each, an “Stockholder Indemnified Party”), to the fullest extent permitted by
applicable law, from and against any expenses, losses, judgments, actions, claims, proceedings (whether commenced or threatened), damages, liabilities or costs (including, without limitation, reasonable attorneys’ fees), whether joint or
several (collectively, “Losses”), as incurred, arising out of or based upon any Misstatement contained in any Registration Statement under which the sale of such Registrable Securities was registered under the 1933 Act, any
preliminary Prospectus, final Prospectus or summary Prospectus contained in such Registration Statement, any amendment or supplement to such Registration Statement, preliminary Prospectus, final Prospectus or summary Prospectus, or any free writing
prospectus relating to such Registration Statement, or any violation by the Company of the 1933 Act or any rule or regulation promulgated thereunder applicable to the Company or any state securities (or Blue Sky) law, rule or regulation and relating
to action or inaction required of the Company in connection with any such Registration; and the Company shall promptly reimburse the Stockholder Indemnified Party for any reasonable, customary and documented out-of-pocket legal and any other expenses incurred, as incurred, by such Stockholder Indemnified Party in connection with investigating and defending any such Losses, except, with respect to any Stockholder
of Registrable Securities, to the extent such Stockholder is liable to indemnify the Company for such Losses pursuant to Section 5(b); provided, however, that the indemnity agreement contained in this
Section 5(a) shall not apply to amounts paid in settlement of any claim or proceeding if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, and the Company will
not be liable in any such case to the extent that any such losses, judgments, claims, damages, liabilities or out-of-pocket expenses arises out of or is based upon any
Misstatement made in such Registration Statement in reliance upon and in conformity with information furnished to the Company, in writing, by a Stockholder Indemnified Party expressly for use therein. 

(b) Indemnification by Stockholders. Each Selling Stockholder will, in the event that any Registration is being effected under the 1933
Act pursuant to this Agreement of any Registrable Securities held by such Stockholder and the Company has required all Selling Stockholders to provide such an undertaking on the same terms, indemnify and hold harmless the Company, each of its
directors and officers, legal counsel, accountants and each Underwriter (if any), and each other Selling Stockholder and each other person, if any, who controls another Selling Stockholder or such underwriter within the meaning of the 1933 Act,
against any Losses, insofar as such Losses arise out of or are based upon any Misstatement contained in any Registration Statement under which the sale of such Registrable Securities was Registered under the 1933 Act, any preliminary Prospectus,
final Prospectus or summary Prospectus contained in the Registration Statement, or any amendment or supplement thereto, if the Misstatement was made in reliance upon and in conformity with information furnished in writing to the Company by such
Selling Stockholder expressly for use therein, and shall reimburse the Company, its directors and officers, and each other Selling Stockholder for any reasonable, customary and documented out-of-pocket legal or other expenses incurred by any of them in connection with investigation or defending any such Loss. Each Selling Stockholder’s indemnification obligations hereunder shall be
several and not joint and shall be proportional to and limited to the amount of any net proceeds (after payment of any underwriting fees, discounts, commissions or taxes) actually received by such Selling Stockholder in connection with the sale of
Registrable Securities under a Registration Statement from which such Losses arise, except in the case of fraud or willful misconduct by such Selling Stockholder. 

  
 -12- 













 (c) Conduct of Indemnification Proceedings. Promptly after receipt by any person of
any notice of any Loss in respect of which indemnity may be sought pursuant to Section 5(a) or 5(b), such person (the “Indemnified Party”) shall, if a claim in respect thereof is to be made
against any other person for indemnification hereunder, notify such other person (the “Indemnifying Party”) in writing of the Loss; provided, however, that the failure by the Indemnified Party to notify the
Indemnifying Party shall not relieve the Indemnifying Party from any liability which the Indemnifying Party may have to such Indemnified Party hereunder, except and solely to the extent the Indemnifying Party is actually and materially prejudiced by
such failure. If the Indemnified Party is seeking indemnification with respect to any claim or action brought against the Indemnified Party, then the Indemnifying Party shall be entitled to participate in such claim or action, and, to the extent
that it wishes, jointly with all other Indemnifying Parties, to assume control of the defense thereof with counsel reasonably satisfactory to the Indemnified Party. After notice from the Indemnifying Party to the Indemnified Party of its election to
assume control of the defense of such claim or action, the Indemnifying Party shall not be liable to the Indemnified Party for any legal or other expenses subsequently incurred by the Indemnified Party in connection with the defense thereof;
provided, however, that in any action in which both the Indemnified Party and the Indemnifying Party are named as defendants, the Indemnified Party shall have the right to employ separate counsel (but no more than one such separate
counsel, in addition to local counsel) to represent the Indemnified Party and its controlling persons who may be subject to liability arising out of any claim in respect of which indemnity may be sought by the Indemnified Party against the
Indemnifying Party, with the reasonable and documented fees and expenses of such counsel to be paid by such Indemnifying Party if, based upon the opinion of counsel of such Indemnified Party, representation of both parties by the same counsel would
be inappropriate due to actual or potential differing interests between them. No Indemnifying Party shall, without the prior written consent of the Indemnified Party, consent to entry of judgment or effect any settlement of any claim or pending or
threatened proceeding in respect of any Losses for which the Indemnified Party seeks indemnification hereunder if such settlement or judgment includes any non-monetary remedies binding on the Indemnified
Party, requires an admission of fault or culpability on the part of the Indemnified Party or does not include an unconditional release from all liability of the Indemnified Party in respect of such Losses. 

(d) Contribution. If the indemnification provided for in the foregoing Sections 5(a) and 5(b) is unavailable to
any Indemnified Party in respect of any Loss referred to herein, then each such Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such Indemnified Party as a result of such Loss in
such proportion as is appropriate to reflect the relative fault of the Indemnified Parties and the Indemnifying Parties in connection with the actions or omissions which resulted in such Loss. The relative fault of any Indemnified Party and any
Indemnifying Party shall be determined by reference to, among other things, whether the Misstatement relates to information supplied by such Indemnified Party or such Indemnifying Party (in the case of a Stockholder, such Misstatement was made in
reliance upon and in conformity with information furnished in writing to the Company by such Stockholder expressly for use therein) and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such
Misstatement. The parties hereto agree that it would not be just and equitable if contribution pursuant to this Section 5(d) were determined by pro rata allocation or by any other method of allocation which
does not take account of the equitable considerations referred to in this Section 5(d). The amount paid or payable by an Indemnified Party as a result of any Loss referred to in this paragraph shall be deemed to
include, subject to the limitations set forth above, any legal or other expenses incurred by such Indemnified Party in connection with investigating or defending any such action or claim. Notwithstanding the provisions of this
Section 5(d), 

  
 -13- 













 
no Stockholder shall be required to contribute any amount in excess of the dollar amount of the net proceeds (after payment of any underwriting fees, discounts, commissions or taxes) actually
received by such Stockholder from the sale of Registrable Securities which gave rise to such contribution obligation, less the aggregate amount of any damages or other amounts such Stockholder has otherwise been required to pay (pursuant to
Section 5(b) otherwise) as a result of the Misstatement. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the 1933 Act) shall be entitled to contribution from any person who was not guilty of such
fraudulent misrepresentation. 
 6. MISCELLANEOUS. 

(a) Effective Date. This Agreement shall be effective as of the Effective Date. 

(b) Amendments and Waivers. This Agreement may be amended only by a writing signed by the Company and the Required Stockholders. The
Company may take any action herein prohibited, or omit to perform any act herein required to be performed by it, only if the Company shall have obtained the written consent to such amendment, action or omission to act, of the Required Stockholders.
Notwithstanding the foregoing, this Agreement may not be amended and the observance of any term of this Agreement may not be waived with respect to any Stockholder without the written consent of such Stockholder unless such amendment or waiver
applies to all Stockholders in the same fashion. 
 (c) Notices. Any notices, consents, waivers or other communications required or
permitted to be given under the terms of this Agreement must be in writing and will be deemed to have been delivered upon receipt, when delivered personally or by a nationally recognized overnight delivery service or by e-mail, in each case properly addressed to the party to receive the same. The addresses for such communications shall be: 

If to the Company: 
 Renovacor,
Inc. 
 5 Mead Point Drive 

Greenwich, CT 06830 
 Attn:
Dr. Magdalene Cook 
 E-mail: mcook@renovacorinc.com 

With copy (which shall not constitute notice) to: 

Troutman Pepper Hamilton Sanders LLP 

3000 Two Logan Square 

Philadelphia, PA 19103-2799 

Attention: Rachael M. Bushey and Jennifer Porter 

Email: busheyr@pepperlaw.com; porterj@pepperlaw.com 

If to any Stockholder, to it at the address set forth under such Stockholder’s name on its signature page hereto, or, in the case of a Stockholder or any
other party named above, at such other address or to the attention of such other Person as the recipient party has specified by written notice given to each other party five (5) days prior to the effectiveness of such change. Written
confirmation of receipt (i) given by the recipient of such notice, consent, waiver or other communication; (ii) provided by affidavit of personal delivery by a delivery service selected by the Company; or (iii) provided by a
nationally recognized overnight delivery service shall be rebuttable evidence of personal service, deposit with a nationally recognized overnight delivery service or electronic transmission. 

  
 -14- 













 (d) Assignments and Transfers by Stockholders. The provisions of this Agreement shall
be binding upon and inure to the benefit of the Stockholders and their respective successors and assigns. A Stockholder may transfer or assign, in whole or from time to time in part, to one or more persons its rights hereunder in connection with the
transfer of Registrable Securities by such Stockholder to such person, provided that such Stockholder complies with all laws applicable thereto or the terms of any contract to which such Stockholder is a party, and provides written notice of
assignment to the Company promptly after such assignment is effected, and such person agrees in writing to be bound by all of the provisions contained herein. 

(e) Assignments and Transfers by the Company. This Agreement may not be assigned by the Company (whether by operation of law or
otherwise) without the prior written consent of the Required Stockholders; provided, however, that in the event that the Company is a party to a merger, consolidation, share exchange or similar business combination transaction in which
the Common Stock is converted into the equity securities of another Person, from and after the effective time of such transaction, such Person shall, by virtue of such transaction, be deemed to have assumed the obligations of the Company hereunder,
the term “Company” shall be deemed to refer to such Person and the term “Registrable Securities” shall be deemed to include the securities received by the Stockholders in connection with such transaction unless such securities
are otherwise freely tradable by the Stockholders after giving effect to such transaction. 
 (f) Benefits of the Agreement. The
terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective permitted successors and assigns of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than
the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement (including Section 5 hereof). 

(g) Counterparts; Execution. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. A PDF or other reproduction of this Agreement may be executed by one or more parties hereto, and an executed copy of this Agreement may be delivered by one or more parties hereto by
e-mail or other electronic transmission device pursuant to which the signature of or on behalf of such party can be seen, and such execution and delivery shall be considered legal, valid, binding and effective
for all purposes. The parties hereto hereby agree that no party shall raise the execution of a PDF or other reproduction of this Agreement, or the fact that any signature or document was transmitted or communicated by
e-mail or other electronic transmission device, as a defense to the formation of this Agreement. 

(h) Headings. The headings of this Agreement are for convenience of reference and shall not form part of, or affect the interpretation
of, this Agreement. 
 (i) Severability. If any provision of this Agreement shall be invalid or unenforceable in any jurisdiction,
such invalidity or unenforceability shall not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction or the validity or enforceability of any provision of this Agreement in any other jurisdiction. The parties
will endeavor in good faith negotiations to replace the prohibited, invalid or unenforceable provision(s) with a valid provision(s), the effect of which comes as close as possible to that of the prohibited, invalid or unenforceable provision(s).

 (j) Further Assurances. The parties shall execute and deliver all such further instruments and documents and take all such other
actions as may reasonably be required to carry out the transactions contemplated hereby and to evidence the fulfillment of the agreements herein contained. 

  
 -15- 













 (k) No Strict Construction. The language used in this Agreement will be deemed to be
the language chosen by the parties thereto express their mutual intent, and no rules of strict construction will be applied against any party. 

(l) Entire Agreement. This Agreement is intended by the parties as a final expression of their agreement and intended to be a complete
and exclusive statement of the agreement and understanding of the parties hereto in respect of the subject matter contained herein. This Agreement supersedes all prior agreements and understandings between the parties with respect to such subject
matter. 
 (m) Governing Law; Consent to Jurisdiction; Waiver of Jury Trial. All questions concerning the construction, validity,
enforcement and interpretation of this Agreement shall be governed by the internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other
jurisdiction) that would cause the application of the laws of any jurisdiction other than the State of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the courts of the State of New York for the adjudication of any
dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to
the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal service of process and
consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such service shall constitute good and sufficient service of
process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. EACH OF THE PARTIES HERETO IRREVOCABLY WAIVES ANY RIGHT TO REQUEST A TRIAL BY JURY FOR THE
ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS AGREEMENT AND REPRESENTS THAT COUNSEL HAS BEEN CONSULTED SPECIFICALLY AS TO THIS WAIVER. 

[remainder of page intentionally left blank] 

  
 -16- 













 IN WITNESS WHEREOF, the parties have executed this Agreement or caused their duly
authorized officers to execute this Agreement as of the date first above written. 
  

			
	COMPANY:


 
			
	
	 RENOVACOR,
INC.



 
			
		
	 By:
	 	/s/ Magdalene Cook
	 Name:
	 	Magdalene Cook
	 Title:
	 	Chief Executive Officer


 [Signature Page to Registration Rights Agreement] 












  

	
	STOCKHOLDER:
	
	 MAGDALENE COOK

	Name of Stockholder
	
	 /s/ Magdalene Cook

(Signature)

	
	 Magdalene Cook

	Name of Signing Party (Please Print)
	
	  
 Title of Signing
Party (Please Print)

	
	 [***]

Tax ID #

	
	 August 31, 2021

	Date Signed


 [Signature Page to Registration Rights Agreement] 












 
	
	STOCKHOLDER:
	
	ACORN BIOVENTURES, L.P.
	By: ACORN CAPITAL ADVISORS GP, LLC
	 Its: General Partner

	Name of Stockholder
	
	 /s/ Isaac Manke

	(Signature)
	
	 Isaac Manke

	Name of Signing Party (Please Print)
	
	 Authorized Person

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	 August 26, 2021

	Date Signed














 
	
	STOCKHOLDER:
	
	 ARTHUR FELDMAN

	Name of Stockholder
	
	 /s/ Arthur Feldman

	(Signature)
	
	 Arthur Feldman

	Name of Signing Party (Please Print)
	
	 Director

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	 August 27, 2021

	Date Signed














 
	
	STOCKHOLDER:
	
	 BIOADVANCE

	Name of Stockholder
	
	 /s/ Frederick Jones

	(Signature)
	
	 Frederick Jones

	Name of Signing Party (Please Print)
	
	 Vice President

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	 August 30, 2021

Date Signed















 
	
	STOCKHOLDER:
	
	 DOUGLAS TILLEY

	Name of Stockholder
	
	 /s/ Douglas Tilley

	(Signature)
	
	 Douglas Tilley

	Name of Signing Party (Please Print)
	
	  
 Title of Signing
Party (Please Print)

	
	 [***]

Tax ID #

	
	 August 27, 2021

	Date Signed














 
	
	STOCKHOLDER:
	
	 RICHARD DRIANSKY TRUST DATED 9/11/96

	Name of Stockholder
	
	 /s/ Robin B. Matlin

	(Signature)
	
	 Robin B. Matlin

	Name of Signing Party (Please Print)
	
	 Trustee and Beneficiary

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	 August 30, 2021

Date Signed















 
	
	STOCKHOLDER:
	
	 JOSEPH Y. CHEUNG

	Name of Stockholder
	
	 /s/ Joseph Y. Cheung

	(Signature)
	
	 Joseph Y. Cheung

	Name of Signing Party (Please Print)
	
	 Renovacor stockholder

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	August 26, 2021
	  
 Date
Signed















 
	
	STOCKHOLDER:
	
	 MARIANNE LARUSSA

	Name of Stockholder
	
	 /s/ Marianne Larussa

	(Signature)
	
	 Marianne Larussa

	Name of Signing Party (Please Print)
	
	  
 Title of Signing
Party (Please Print)

	
	  
 [***]

Tax ID #

	
	 August 30, 2021

Date Signed















 
	
	 STOCKHOLDER:
  

	 RENOVAHOLDING M S.R.L.

	 Name of Stockholder
  

	 /s/ Claudio Giuliano

	 (Signature)
  

	 Claudio Giuliano

	 Name of Signing Party (Please Print)

 

	 Director

	 Title of Signing Party (Please Print)

 
 [***]

	 Tax ID #
  

August 30, 2021

	Date Signed














 
	
	 STOCKHOLDER:
  

	 NEW LEAF BIOPHARMA

	 OPPORTUNITIES II, L.P.

 

	 By: New Leaf BPO Associates II, L.P.

	 Its: General Partner

 

	 By: New Leaf BPO Management II, L.L.C

	 Its: General Partner

 

	 Name of Stockholder
  

	 /s/ Craig Slutzkin

	 (Signature)
  

	 Craig Slutzkin

	 Name of Signing Party (Please Print)

 

	 Chief Financial Officer

	 Title of Signing Party (Please Print)

 
 [***]

	 Tax ID #
  

August 27, 2021

	Date Signed














 
	
	 STOCKHOLDER:
  

	 FRANCESCO LOREDAN

	 Name of Stockholder
  

	 /s/ Francesco Loredan

	 (Signature)
  

	 Francesco Loredan

	 Name of Signing Party (Please Print)

 

	 Title of Signing Party (Please Print)

 
 [***]

	Tax ID #
	
	 August 26, 2021

	Date Signed














 
	
	 STOCKHOLDER:
  

	 BROADVIEW VENTURES I, LLC

	 Name of Stockholder
  

	 /s/ Christopher H. Colecchi

	 (Signature)
  

	 Christopher H. Colecchi

	 Name of Signing Party (Please Print)

 

	 Managing Director

	 Title of Signing Party (Please Print)

 
 [***]

	 Tax ID #
  

	 August 30, 2021

	Date Signed














 
	
	 STOCKHOLDER:
  

	 LONGVIEW HEALTHCARE VENTURES, LLC

	 Name of Stockholder
  

	 /s/ Christopher H. Colecchi

	 (Signature)
  

	 Christopher H. Colecchi

	 Name of Signing Party (Please Print)

 

	 Managing Director

	 Title of Signing Party (Please Print)

 

	 [***]

	 Tax ID #
  

	 August 30, 2021

	Date Signed














 
	
	 STOCKHOLDER:
  

	 ELYSIA CAPITAL I SCSP

	Name of Stockholder
	
	 /s/ Carlo Zuccaro

	(Signature)
	
	 Carlo Zuccaro

	Name of Signing Party (Please Print)
	
	 Director of the General Partner

	Title of Signing Party (Please Print)
	
	 /s/ Krystel Stoffel

	(Signature)
	
	 Krystel Stoffel

	Name of Signing Party (Please Print)
	
	 Director of the General Partner

	Title of Signing Party (Please Print)
	
	 [***]

	Tax ID #
	
	 August 30, 2021

	Date Signed














 
	
	 STOCKHOLDER:
  

	 TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION


	 Name of Stockholder
  

	 /s/ Jaison G. Kurichi

	(Signature)
	
	 Jaison G. Kurichi

	Name of Signing Party (Please Print)
	
	 Associate Vice President for Budget

	 Title of Signing Party (Please Print)

 
 [***]

	 Tax ID #
  

	 August 30, 2021

	Date Signed


 [Signature Page to Registration Rights Agreement] 












 
	
	STOCKHOLDER:
	
	 RICHARD GIROUX

	Name of Stockholder
	
	 /s/ Richard Giroux

	(Signature)
	
	 Richard Giroux

	Name of Signing Party (Please Print)
	
	 Director

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	August 25, 2021
	  
 Date
Signed



 [Signature Page to Registration Rights Agreement] 












 
	
	STOCKHOLDER:
	
	 CHARDAN INVESTMENTS 2, LLC

	Name of Stockholder
	
	 /s/ Jonas Grossman

	(Signature)
	
	 Jonas Grossman

	Name of Signing Party (Please Print)
	
	 Managing Member

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	 August 23, 2021

	Date Signed


 [Signature Page to Registration Rights Agreement] 












 
	
	STOCKHOLDER:
	
	 ISAAC MANKE

	Name of Stockholder
	
	 /s/ Isaac Manke

	(Signature)
	
	 Isaac Manke

	Name of Signing Party (Please Print)
	
	 Stockholder

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	August 24, 2021
	  
 Date
Signed



 [Signature Page to Registration Rights Agreement] 












 
	
	STOCKHOLDER:
	
	 MICHAEL RICE

	Name of Stockholder
	
	 /s/ Michael Rice

	(Signature)
	
	 Michael Rice

	Name of Signing Party (Please Print)
	
	 Founding Partner

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	 August 27, 2021

	Date Signed


 [Signature Page to Registration Rights Agreement] 












 
	
	STOCKHOLDER:
	
	 MATTHEW ROSSEN

	Name of Stockholder
	
	 /s/ Matthew Rossen

	(Signature)
	
	 Matthew Rossen

	Name of Signing Party (Please Print)
	
	 Director

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	 August 24, 2021

	Date Signed


 [Signature Page to Registration Rights Agreement] 












 
	
	STOCKHOLDER:
	
	 R.A. SESSION II

	Name of Stockholder
	
	 /s/ RA Session II

	(Signature)
	
	 RA session II

	Name of Signing Party (Please Print)
	
	 Director

	Title of Signing Party (Please Print)
	
	 [***]

Tax ID #

	
	August 27, 2021
	  
 Date
Signed



 [Signature Page to Registration Rights Agreement] 












 EXHIBIT A 

Initial Stockholders 
  

									
	 Stockholder Name
	  	Initial Shares	 	  	Initial Warrants	 
	 Michael Rice
	  	 	10,000	 	  	 	—  	 
	 Richard Giroux
	  	 	10,000	 	  	 	—  	 
	 Matthew Rossen
	  	 	10,000	 	  	 	—  	 
	 Isaac Manke
	  	 	10,000	 	  	 	—  	 
	 R.A. Session II
	  	 	10,000	 	  	 	—  	 
	 Chardan Investments 2, LLC
	  	 	2,105,661	 	  	 	3,500,000	 
	 Total:
	  	 	2,155,661	 	  	 	3,500,000	 

 Renovacor Stockholders 
  

													
	 Stockholder Name
	  	Merger Shares	 	  	PIPE Shares	 	 	Earnout Shares (%)	 
	 Arthur Feldman
	  	 	994,433	 	  	 	10,000	 	 	 	19.53	% 
	 Richard Driansky Trust dated 9/11/96
	  	 	296,637	 	  	 	—  	 	 	 	5.87	% 
	 Douglas Tilley
	  	 	39,551	 	  	 	—  	 	 	 	0.78	% 
	 Marianne LaRussa
	  	 	19,775	 	  	 	—  	 	 	 	0.39	% 
	 Joseph Y. Cheung
	  	 	39,551	 	  	 	—  	 	 	 	0.78	% 
	 Temple University – Of The Commonwealth of Pennsylvania
	  	 	95,228	 	  	 	—  	 	 	 	1.88	% 
	 Magdalene Cook
	  	 	401,448	 	  	 	50,000	 	 	 	7.35	% 
	 BioAdvance
	  	 	380,419	 	  	 	—  	 	 	 	5.02	% 
	 Broadview Ventures I, LLC
	  	 	443,823	 	  	 	—  	 	 	 	5.86	% 
	 Longview Healthcare Ventures, LLC
	  	 	204,936	 	  	 	325,770	 	 	 	2.93	% 
	 Novartis Bioventures Ltd.
	  	 	697,436	 	  	 	—  	 	 	 	9.21	% 
	 New Leaf BioPharma Opportunities II, L.P.
	  	 	697,436	 	  	 	—  	 	 	 	9.21	% 
	 Renovaholding S.r.l.
	  	 	437,120	 	  	 	194,953	 	 	 	5.90	% 
	 Elysia Capital I SCSp
	  	 	220,949	 	  	 	85,147	 	 	 	2.97	% 
	 Francesco Loredan
	  	 	33,477	 	  	 	12,900	 	 	 	0.45	% 
	 Acorn Bioventures, L.P.
	  	 	1,302,842	 	  	 	1,071,230	 (1) 	 	 	17.99	% 

  

	(1)	 Includes shares underlying pre-funded warrants. 














 EXHIBIT B 

Plan of Distribution 
 The selling
stockholders, which as used herein includes donees, pledgees, transferees or other successors-in-interest selling shares of common stock or interests in shares of common
stock received after the date of this prospectus from a selling stockholder as a gift, pledge, partnership distribution or other transfer, may, from time to time, sell, transfer or otherwise dispose of any or all of their shares of common stock or
interests in shares of common stock on any stock exchange, market or trading facility on which the shares are traded or in private transactions. These dispositions may be at fixed prices, at prevailing market prices at the time of sale, at prices
related to the prevailing market price, at varying prices determined at the time of sale, or at negotiated prices. 
 The selling stockholders may use any
one or more of the following methods when disposing of shares or interests therein: 
  

	 	•	 	 ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;



  

	 	•	 	 block trades in which the broker-dealer will attempt to sell the shares as agent, but may position and resell a
portion of the block as principal to facilitate the transaction; 


  

	 	•	 	 purchases by a broker-dealer as principal and resale by the broker-dealer for its account; 



 

	 	•	 	 an exchange distribution in accordance with the rules of the applicable exchange; 



 

	 	•	 	 privately negotiated transactions; 



 

	 	•	 	 short sales effected after the date the registration statement of which this prospectus is a part is declared
effective by the SEC; 


  

	 	•	 	 through the writing or settlement of options or other hedging transactions, whether through an options exchange
or otherwise; 


  

	 	•	 	 broker-dealers may agree with the selling stockholders to sell a specified number of such shares at a stipulated
price per share; 


  

	 	•	 	 a combination of any such methods of sale; and 



 

	 	•	 	 any other method permitted by applicable law. 



The selling stockholders may, from time to time, pledge or grant a security interest in some or all of the shares of common stock owned by them and, if they
default in the performance of their secured obligations, the pledgees or secured parties may offer and sell the shares of common stock, from time to time, under this prospectus, or under an amendment or supplement to this prospectus under Rule
424(b)(3) or other applicable provision of the 1933 Act amending the list of selling stockholders to include the pledgee, transferee or other successors in interest as selling stockholders under this prospectus. The selling stockholders also may
transfer the shares of common stock in other circumstances, in which case the transferees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus. 












 In connection with the sale of our common stock or interests therein, the selling stockholders may enter
into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of the common stock in the course of hedging the positions they assume. The selling stockholders may also sell shares of our
common stock short and deliver these securities to close out their short positions, or loan or pledge the common stock to broker-dealers that in turn may sell these securities. The selling stockholders may also enter into option or other
transactions with broker-dealers or other financial institutions or the creation of one or more derivative securities which require the delivery to such broker-dealer or other financial institution of shares offered by this prospectus, which shares
such broker-dealer or other financial institution may resell pursuant to this prospectus (supplemented or amended as necessary to reflect such transaction). 

The aggregate proceeds to the selling stockholders from the sale of the common stock offered by them will be the purchase price of the common stock less
discounts or commissions, if any. Each of the selling stockholders reserves the right to accept and, together with their agents from time to time, to reject, in whole or in part, any proposed purchase of common stock to be made directly or through
agents. We will not receive any of the proceeds from this offering. 
 The selling stockholders also may resell all or a portion of the shares in open
market transactions in reliance upon Rule 144. 
 The selling stockholders and any underwriters, broker-dealers or agents that participate in the sale of
the common stock or interests therein may be deemed to be “underwriters” within the meaning of Section 2(11) of the 1933 Act. Any discounts, commissions, concessions or profit they earn on any resale of the shares may be underwriting
discounts and commissions under the 1933 Act. To the extent required, the shares of our common stock to be sold, the names of the selling stockholders, the respective purchase prices and public offering prices, the names of any agents, dealer or
underwriter, any applicable commissions or discounts with respect to a particular offer will be set forth in an accompanying prospectus supplement or, if appropriate, a post-effective amendment to the registration statement that includes this
prospectus. 
 In order to comply with the securities laws of some states, if applicable, the common stock may be sold in these jurisdictions only through
registered or licensed brokers or dealers. We have advised the selling stockholders that the anti-manipulation rules of Regulation M under the 1934 Act may apply to sales of shares in the market and to the activities of the selling stockholders and
their Affiliates. In addition, to the extent applicable we will make copies of this prospectus (as it may be supplemented or amended from time to time) available to the selling stockholders for the purpose of satisfying any prospectus delivery
requirements of the 1933 Act. The selling stockholders may indemnify any broker-dealer that participates in transactions involving the sale of the shares against certain liabilities, including liabilities arising under the 1933 Act. 

We have agreed to indemnify the selling stockholders against liabilities, including liabilities under the 1933 Act and state securities laws, relating to the
registration of the shares offered by this prospectus. 
 We have agreed with the selling stockholders to keep the registration statement of which this
prospectus constitutes a part effective until the earlier of (1) such time as all of the shares covered by this prospectus have been disposed of pursuant to and in accordance with such registration statement or (2) the date on which all of
the shares may be sold by the selling stockholders without restriction (including any current public information requirement) pursuant to Rule 144.