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## APPENDIX E

Results from SIP and STIR Modeling

I. SIP (Screening Imbibition Program) Model Input and Output

Table 1. Inputs

Parameter Value

Chemical name sulfoxaflor

Solubility (in water at 25 o C; mg/L) 1380

Mammalian LD 50 (mg/kg

- bw) 1000

Mammalian test species laboratory rat

Body weight (g) of "other" mammalian

species 20

Mammalian NOAEL (mg/kg

- bw) 6.07

Mammalian test species laboratory rat

Body weight (g) of "other" mammalian

species 20

Avian LD 50 (mg/kg

- bw) 80

Avian test species other

Body weight (g) of "other" avian species 12

Mineau scaling factor 1.15

Mallard NOAEC (mg/kg

- diet) 200

Bobwhite quail NOAEC (mg/kg

- diet) 0

NOAEC (mg/kg

- diet) for other bird species

Body weight (g) of other avian species

NOAEC (mg/kg

- diet) for 2nd other bird

species

Body weight (g) of 2nd other avian species

Table 2. Mammalian Results

Parameter Acute Chronic

Upper bound exposure (mg/kg

- bw) 237.3600 237.3600

Adjusted toxicity value (mg/kg

- bw) 769.1606 4.6688

Ratio of exposure to toxicity 0.3086 50.8396

Conclusion* Exposure through

drinking water alone is a

potential concern for

mammals Exposure through

drinking water alone is a

potential concern for

mammals

Table 3. Avian Results

Parameter Acute Chronic

Upper bound exposure (mg/kg

- bw) 1117.8000 1117.8000

Adjusted toxicity value (mg/kg

- bw) 86.3709 9.9225

Ratio of exposure to acute toxicity 12.9419 112.6529

Conclusion* Exposure through

drinking water alone is a

potential concern for

birds Exposure through

drinking water alone is a

potential concern for

birds

### 2 II. STIR Input and Output



# Input

Application and Chemical Information

Enter Chemical Name sulfoxaflor

Enter Chemical Use seed treatment

Is the Application a Spray? (enter y or n) n

If Spray What Type (enter ground or air) ground

Enter Chemical Molecular Weight (g/mole) 277

Enter Chemical Vapor Pressure (mmHg) 1.10E

- 08

Enter Application Rate (lb a.i./acre) 0.133

Toxicity Properties

**Bird**

Enter Lowest Bird Oral LD 50 (mg/kg bw) 80

Enter Mineau Scaling Factor

Enter Tested Bird Weight (kg) 0.012

**Mammal**

Enter Lowest Rat Oral LD 50 (mg/kg bw) 1000

Enter Lowest Rat Inhalation LC 50 (mg/L) 1.9

Duration of Rat Inhalation Study (hrs) 4

Enter Rat Weight (kg) 0.225



# Output

Results Avian (0.020 kg ) Conclusion

Maximum Vapor Concentration in Air at Saturation

(mg/m 3 ) 1.64E

- 04

Maximum 1

- hour Vapor Inhalation Dose (mg/kg) 2.06E

- 05

Adjusted Inhalation LD 50 1.10E+00

Ratio of Vapor Dose to Adjusted Inhalation LD 50 1.88E

- 05 Exposure NOT

likely significant

Maximum Post

- treatment Spray Inhalation Dose (mg/kg) not applicable

Ratio of Droplet Inhalation Dose to Adjusted Inhalation

LD 50 not applicable



### Results Mammalian (0.015 kg )

Maximum Vapor Concentration in Air at Saturation

(mg/m 3 ) 1.64E

- 04

Maximum 1

- hour Vapor Inhalation Dose (mg/kg) 2.59E

- 05

Adjusted Inhalation LD 50 1.58E+02

Ratio of Vapor Dose to Adjusted Inhalation LD 50 1.64E

- 07 Exposure NOT

likely significant

Maximum Post

- treatment Spray Inhalation Dose (mg/kg) not applicable

Ratio of Droplet Inhalation Dose to Adjusted Inhalation

LD 50 not applicable

### 3