Support Documents for 

Significant New Use Rules (SNUR) on 

Premanufacture Notices (PMN) 

P-12-196 

EPA Docket EPA-HQ-OPPT-2012-0740 

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Index 

A-001 Structure Activity Team (SAT) Report for 

 PMN P-12-196 

A-002 Initial Review Engineering Report for 

 PMN P-12-196 

A-003 Post Focus Exposure Report for 

 PMN P-12-196 

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A-001 

Structure Activity Team (SAT) Report 

 for PMN P-12-196 

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SAT Report

PMN Number: P-12-0196

SAT Date: 3/6/2012

Print Date: 5/31/2012

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 3 Health: ; Eco: chronic concerns only

 Persistence Bioaccum Toxicity Comments

2 31

Exposure Based Review:

Health: Yes

Ecotox: Yes

Routes of exposure: Health: Dermal Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: LIVER, UNCERT-HEALTH, AQUATOX-C

Summary of Assessment:

 Fate:

Fate Summary: P-12-0196

FATE: Estimations for low weight MW 286 

Liquid with MP < 25 C (E)

log Kow = 7.49 (E) 

S = 0.012 mg/L at 25 C (E)

VP = 7.8E-6 torr at 25 C (E)

BP > 400 C (E)

H = 6.43E-6 (E)

log Koc = 6.28 (E)

log Fish BCF = 3.89 (E)

log Fish BAF = 3.58 (E) 

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POTW removal (%) = 90 via sorption

Time for complete ultimate aerobic biodeg ≥ mo

Sorption to soils/sediments = v.strong

Volatilization half-life from a standard river = 240 hrs

Volatilization half-life from a standard lake = 77 da

Atmospheric Oxidation Half-life = 6.4 hr via OH radical

PBT Potential: P2B3

*CEB FATE: Migration to ground water = negl

 Health:

 Health Summary: Absorption of the lower molecular weight components is 

poor all routes based on physical/chemical properties. There is uncertain concern for health 

effects. The PMN material may cause adverse liver effects. Low moderate concern. 

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 *

daphnid 48-h LC50 *

green algal 96-h EC50 *

fish _ chronic value 0.001

daphnid _ chronic 

value

0.001

algal _ chronic 

value

0.013 or *

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs neutral organic chemicals; SAR 

chemical class = ; MW 286; log Kow = 7.49 (EPI, smaller structure); liquid (M); S 

= 0.012 mg/L C (P); pH7; effective concentrations based on 100% active ingredients and mean 

measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

1

SARs neutral organic chemicals

SAR Class

Ecotox Category Neutral Organics

Ecotox Factors Comments: 

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 SAT Chair: Becky Jones

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A-002 

Initial Review Engineering Report 

 for PMN P-12-196 

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INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0196

Focus Ready Draft 3/15/2012

ENGINEER: Hall \ JD

PV (kg/yr): 

SUBMITTER: 

USE:

OTHER USES:

MSDS: No Label: No

TLV/PEL:

CRSS :

Consumer Use: No

SAT (concerns) (03/06/2012):

Related Cases and Related Cases and Misc SAT Info:

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Ecotox Related Cases: 

Migration to groundwater: Negligible

PBT rating: P2B3T1 .

Health: 1-2 Dermal, Inhalation

Eco: 3 Water (All releases to water with a CC = 1 ppb.)

OCCUPATIONAL EXPOSURE RATING: 1A

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

POLLUTION PREVENTION CONSIDERATIONS:

None.

INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0196

Number of Sites/ Location: 

Days/yr: 

Basis:

Process Description: 

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ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below

may coincide with daily releases from the other sources

to the same medium.

RELEASE TOTAL

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 

Basis

Inhalation:

Dermal:

INITIAL REVIEW ENGINEERING REPORT 

PMN: 12-0196

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Number of Sites/ Location: 

Days/yr: 

Basis:

Process Description: 

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below

may coincide with daily releases from the other sources

to the same medium.

RELEASE TOTAL

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 

Basis: 

Dermal:

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A-003 

Initial Review Exposure Report 

 for PMN P-12-196 

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5/11/12 page of 

POST FOCUS EXPOSURE REPORT 

This updated assessment is based on Test Data Engineering Report, Post-Focus Draft 

Revision 1, dated 5/9/2012. 

 Chemical ID: P-12-0196 Reviewer: Wong/SS 

 

Results Table: Dose, Concentration, and Days Exceeded Results Summary 

Exposure Scenario1 Water Landfill Stack Air Fugitive Air 

Drinking Water Fish Ingestion 

ADR LADD ADR LADD 7Q104 

CC = 1 

PDM 

Days 

Exceede

d 

LADD ADR LADD ADR LADD 

Release 

activity(ies)2; 

exposure 

calculation(s)3 

mg/kg/day m g/kg/day mg/kg/day mg/kg/day μg/l # Days mg/kg/day m g/kg/day mg/kg/day m g/kg/day mg/kg/day 

Max 

ADR 

--- --- --- --- --- --- --- 1.44E-04 --- --- --- 

Max 

LADD 

--- --- --- --- --- --- --- --- 3 .15E-08 --- --- 

1 Exposure scenario titles consist of release activity followed by exposure calculation abbreviation. 

2 Release activities are from engineering report's Manufacturing (Mfg), Processing (Proc) and Use release 

activity labels.Multiple release activities are combined in one exposure scenario if their releases occur at 

same location. 

3 Exposure calculations are Acute Dose Rate (ADR), Lifetime Average Daily Dose (LADD), and 

Probabilistic Dilution Model (PDM). There may be one, two, or all three exposure calculations per exposure 

scenario.CC is the aquatic concentration of concern. 

4 This column displays concentration values for the 7Q10 streamflow, which is defined as the average daily 

streamflow of the seven consecutive days of lowest flow within a ten year period. 

Remarks: 

Results Table: Exposure Based (XB)/Persistent (P2B2) Criteria 

Parameter Exp Based Persistent Exceedance Value 

Drinking (Surface) Water Dose (mg/kg/day) No No 

Fish Ingestion Dose (mg/kg/day) No No 

Inhalation Dose (mg/kg/day) No No 

Groundwater Dose (mg/kg/day) No No 

Surface Water Release After Treatment (kg/yr) No No 

Total Release After Treatment (kg/yr) No No 

Consumer Use? No 

Fate test recommendations?: (default is NA)

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5/11/12 page of 

 POST FOCUS EXPOSURE REPORT 

Chemical ID: P-12-0196 Assessor: Wong/SS 

ENVIRONMENTAL RELEASES 

 Scenario#:1 Number of Release Sites: 

 Release Activity: Max ADR 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (k g/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg /site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

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5/11/12 page of 

POST FOCUS EXPOSURE REPORT 

Chemical ID: P-12-0196 

INHALATION EXPOSURE ESTIMATES (POST-TREATMENT) 

SCENARIO #: 1 RELEASE ACTIVITY: Max ADR 

RELEASE DESCRIPTION: 

METHOD OF CALCULATION: Screen3 

EXPOSED POPULATION: Adult 

Number of Sites: 

Per Site Fugitive Release: kg/site/day 

Fugitive Release Days per Year: days 

% Removal via Fugitive Release: % 

Total Fugitive Release: kg/yr 

Max Annual Average Air Concentration 

(Fugitive): 

0.00 μg/ m3

Max 24 Hour Average Air 

Concentration(Fugitive): 

0.00 μg/ m3

Per Site Stack Release: kg/site/day 

Stack Release Days per Year: days 

% Removal via Stack Release: % 

Total Stack Release: kg/yr 

Max Annual Average Air Concentration (Stack): 4.28E-04 μg/m3

Max 24 Hour Average Air Concentration (Stack): 0.78 μg/m3

ASSUMPTIONS 

Exposure Units 

Results 

(Stack) 

Results 

(Fugitive) ED 

(years) 

AT 

(years) 

BW 

(kg) 

Inh. Rate 

(m3/hr) 

Cancer 

LADDpot (mg/kg/day) 3.15E-08 N/A 30.00 75.00 71.80 0.55 

LADCpot (mg/m3) 1.71E-07 N/ A 30.00 75.00 NA NA 

Acute 

ADRpot (mg/kg/day) 1.44E-04 N/A NA 1 day 71.80 0.55 

Inhalation Comments: 

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5/11/12 page of 

 Stack Parameter Data Fugitive Parameter Data 

Stack Height 10.00 m Release Height: N/A 

Inside Stack 

Diameter: 

0.10 m Length of Release 

Opening: 

N/A 

Stack Gas Exit 

Velocity: 

0.10 m /sec Width of Release 

Opening: 

N/A 

Stack Gas 

Temperature: 

293.00 K 

 

 Meteorological and Terrain Information: 

Surrounding Land Use: Rural 

Terrain Height: 0.00 m 

Distance to Residence of Interest: 100.00 m 

Meteorological Class: Full 

Stability Class: NA 

Wind Speed: NA 

 

 Do wnwash Information: 

Facility Length: NA m 

Facility Width: NA m 

Facility Height: NA m 

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5/11/12 page of 

 POST FOCUS EXPOSURE REPORT 

Chemical ID: P-12-0196 Assessor: Wong/SS 

ENVIRONMENTAL RELEASES 

 Scenario#:2 Number of Release Sites: 

 Release Activity: Max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (k g/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg /site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

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5/11/12 page of 

POST FOCUS EXPOSURE REPORT 

Chemical ID: P-12-0196 

INHALATION EXPOSURE ESTIMATES (POST-TREATMENT) 

SCENARIO #: 2 RELEASE ACTIVITY: Max LADD 

RELEASE DESCRIPTION: 

METHOD OF CALCULATION: Screen3 

EXPOSED POPULATION: Adult 

Number of Sites: 

Per Site Fugitive Release: kg/site/day 

Fugitive Release Days per Year: days 

% Removal via Fugitive Release: % 

Total Fugitive Release: kg/yr 

Max Annual Average Air Concentration 

(Fugitive): 

0.00 μg/ m3

Max 24 Hour Average Air 

Concentration(Fugitive): 

N/A μg/m 3

Per Site Stack Release: kg/site/day 

Stack Release Days per Year: days 

% Removal via Stack Release: % 

Total Stack Release: kg/yr 

Max Annual Average Air Concentration (Stack): 4.28E-04 μg/m3

Max 24 Hour Average Air Concentration (Stack): N/A μg/m3

ASSUMPTIONS 

Exposure Units 

Results 

(Stack) 

Results 

(Fugitive) ED 

(years) 

AT 

(years) 

BW 

(kg) 

Inh. Rate 

(m3/hr) 

Cancer 

LADDpot (mg/kg/day) 3.15E-08 N/A 30.00 75.00 71.80 0.55 

LADCpot (mg/m3) 1.71E-07 N/ A 30.00 75.00 NA NA 

Acute 

ADRpot (mg/kg/day) N/A N/A NA 1 day 71.80 0.55 

Inhalation Comments: 

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5/11/12 page of 

 Stack Parameter Data Fugitive Parameter Data 

Stack Height 10.00 m Release Height: N/A 

Inside Stack 

Diameter: 

0.10 m Length of Release 

Opening: 

N/A 

Stack Gas Exit 

Velocity: 

0.10 m /sec Width of Release 

Opening: 

N/A 

Stack Gas 

Temperature: 

293.00 K 

 

 Meteorological and Terrain Information: 

Surrounding Land Use: Rural 

Terrain Height: 0.00 m 

Distance to Residence of Interest: 100.00 m 

Meteorological Class: Full 

Stability Class: NA 

Wind Speed: NA 

 

 Do wnwash Information: 

Facility Length: NA m 

Facility Width: NA m 

Facility Height: NA m 

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