## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460



## MEMORANDUM



# Date : February 28,2013 OFFICE OF CHEMICAL SAFETY

AND POLLUTION PREVENTION



## SUBJECT: 

# Endothall: Chronic Aggregate Dietary (Food plus Drinking Water) Exposure

Assessment to Support permanent tolerance on Apple

PC Codes: 038901,038904 and 038905 DP Barcode: 0407814

Decision No.: 464243 Registration Nos.: 70506

- 174,70506-175,70506-176,70506-191

Petition No.: N / A Regulatory Action: Section 3

Risk Assessment Type: Dietary Case No.: 2245

TXR No.: NA CAS Nos.: 145-73-3; 2164-07-0; 66330-88-9

MRID No.: N / A 40 CFR: § 180 .293



## FROM: Seyed Tad ayon, Chemist

# ~ RAB5/Health Effects Division (7509P)

THROUGH: David Hrdy, Senior

# Biologis~f(.ffik Ideliz Negr6n-Encamaci6n,

# Ph.D.,Chemis~**~** Dietary Exposure Science Advisory Council (DESAC)

Health Effec ts Division (7509P)

and 

# M

Michael Me tzger, Branch Chief

RAB5/Health Effects Division (750 

# ;j!)

TO: Seyed Tadayon, Chemist

RAB5/Health Effects Division (7509P)

Page I of30

## Executive Summary

A chronic aggregate dietary (food a nd drinking wa te r) exposure and r isk assessment was conducted

using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database

DEEM-FCIDTM, Version 3.16 which uses food consumption data from the U .S

. Department of

Agriculture's National Health and Nutrition Examination Survey)/"What We Ea t in America"

(NHANES/WWEIA) dietary survey conducted in 2003-2008

. The analysis was performed to

evaluate requested new use of endothall on apple. Based on toxico lo gica l information, acute and

cancer assessments are not necessary for endothall.

Chronic Dietary Exposure Results and Characterization

A refined, chronic d ietary exposure and risk assessment was conducted incorporating both food and

water residues. The assessmen t assumed estimates of crops irrigation, percent crop treated for

endothall from BEAD, ave r age field tria l res id ues for all existing tolerances (including indirect or

inadvertent or FHE?) and new uses of endothall, DEEM 7

. 81 defaul t and crop specific processing

factors for all commodities. T h e drinking wa ter inputs we re based on modeled surface water values

from the scenario which is li kely to provide the highest estimated en vi ronmental concentration.

T ypically, HED has concerns regarding dietary risk when the exposure estimates exceed 1 00% of

the chronic populat i on adjusted dose (cPAD)

. The estimated exposure (food and water) to the U.S.

population from the existing and proposed new uses of endothall re s ulted in an estimated risk

equ iv alent to 32% of the cPAD. T he mo s t highly exposed population subgroup i s i nfants (1-2 years

old) w ith an exposure equiva lent to an estimated risk of90% ofthe cPAD.

I

. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For chronic

assessments, the risk i s expressed as a percen tag e of a maximum acceptable dose (i.e., the dose

which HED has concluded will result in no unreasonable adverse health effects). This dose is

referred to as the popu l ation adjusted dose (PAD). Th e PAD is equivalent to point of departure

(POD, NOAE L

, LOAEL

, e.g.) divided by the required uncertainty or safety factors

.

For chronic exposures, HED is concerned when estimated d i etary risk exceeds 1 00% of th e PAD.

References which discuss the acute and chronic risk assessments in more detail are available on the

EPA/pesticides web s i te : "Available In fo rmation on Assessing Exposure from Pesticides, A User's

Guide ," 21-JUN-2000, web link: http://www. epa. gov/f edrgstr/EPA -PE ST/2000/July/Day12 /60 6l.pdf; or see SOP 99 .6 (20-AUG-1999)

.

The most recent dietary risk assessment for endothall was conduc te d by D. Soderberg (05/02/2011,

DP 386982).

II. Residue Information

Registered and Proposed Endothall T olerances

Endo thall is a selec tive contact herbicide, defo liant

, desiccant, and aquatic algicide belonging to the

d i carboxylic acid chemical class. The free acid of endothall and its d ipo tassium and mono-N,N

dimethylalkyl-amine salts (monoalkylam i ne) are reg i stered in the United States primarily as aquatic

Page 2 of30

### Page 3 of 30



## herbicides for the control of a variety of plants in water bodies. This registration currently includes

application to irrigation canals with no restrictions except a holding time before livestock can be

allowed access. Endothall is also registered for desiccation/de

- foliation of alfalfa/clover (grown for

seed only), cotton, and potatoes prior to harvest, and for reduction of sucker branch growth in hops.

Permanent tolerances have been established for the combined residues of endothall and its

monomethyl ester in/on all crops and on fish and livestock [40 CFR §180.293(a)(1)]

.

There are currently four endothall end

- use products registered to United Phosphorus, Inc. (UPI) for

control of algae and aquatic weeds in drainage and irrigation canals, including two monoalkylamine

salt fo rmulations and two dipotassium salt formulations. The monoalkylamine salt of endothall is

formulated as either a 2 lb ae/gal SC/L formulation (EPA Reg. No. 70506

- 175) or an 11% granular

(G) formulation (EPA Reg. No. 70506

- 174), containing 5% ae. The dipo tassium salt is formulated

as a 4.23 lb ai/gal SC/L (EPA Reg. No. 70506

- 176), which is equivalent to 3.0 lb ae/gal SC/L, and

as a 63% granular formulation (EPA Reg. No. 70506

- 191) , which is 44.7 ae

.

The qualitative nature of endothall residues in plants is adequately understood based upon the

metabolism studies on alfalfa, cotton and sugar beets. The qualitative nature of endothall residues

in livestock is also understood based upon the adequate goat and poultry metabolism studies. The

Agency has conclu ded that endothall and its monomethyl ester are the residues of concern in both

plant and animal commodities for purposes of risk assessment ( D370449 , date, author )

. The

analyses in submitted studies includes a derivatization in strong phosphoric acid, wh ich is expected

to hydrolyze any monomethyl esters that are present back to the parent, so that both are ultimately

measured as a common moiety. We note however, that the recovery of the monomethyl ester was

not tested for the newly submitted livestock fe eding studies; therefore the assessment presented here

must be understood to be contingent upon evidence that the method does reliably recover the

monomethy ester metabolite from livestock tissues. The residue of concern in water is endothall

only ( D37044 9 , author, date )

.

The rationale for the residue levels and crop translation included in the dietary assessment was

discussed in previous assessments (D86 982, D370449

.... ). For the n ew use of endothall on apple

t he proposed label recommends single applica tion of 0. 423 lbs ai/acre of endothall on apple tree and

a 70

- days pre

- harvest interval . HED has recommended that a tolerance of 0.05 ppm be established

for apple

. However, a residue level of 0.041 ppm is used based on average residue values from crop

field trial data. A processing study depicting concentration of residues in apple juice suggest an

empirical processing factor of 1.2....

Summary of Dietary Exposure Input Data for Foods

In order to refine the calculations, average results from the field trials were used for all crops, not

the recommended tolerances. A detailed list of foods, residue values and processing factors used in

this assessment is shown in Table 1.

BEAD provide d estimates of the extent to which some crops are treated . BEAD’s memo (D369862,

D369863) are included as Attachment 3

.

### Page 4 of 30

Table 1

. Residue Summary for Endothall.

Commodity Residue

s (ppm) Percent Crop

Treated Processing

Factor Comments

Vegetable, root and tuber, group 1 0.33 100 1 Based on average residues in sugar beets

Carrots 0.08 100 1 carrots

Potatoes 0.08 100 1 potatoes

Potatoes, dry 100 6.5 Potatoes

Beet, sugar 0.33 37 1 Based on average residues in sugar beets

Beet, sugar. Sugar 0.33 37 0 Based on average residues in sugar beets, and processing to

zero residues

Beet, sugar, molasses 0.33 37 2.4 Average residues in sugar beet roots and 2.4x processing

factor.

Ginger, dried 0.33 100 1 No default processing factor

Root crop Tops, Crop Group 2 1.3 100 From sugar beet tops

Vegetable, bulb, group 3A green onions 0.26 100 1 Based on average residues in green onions

Bulb onions 0.05 100 1 dry bulb onions (<0.05 ppm)

Bulb onion, dried 0.05 100 9.0 dry bulb onions (<0.05 ppm)

Vegetable, leafy, except head lettuce, endive, and other

closed head varieties of leafy vegetables 0.71 100 1 Based on residues in leaf lettuce (0.71 ppm)

Head lettuce, endive and celery 0.32 100 1 Based on average residues in head lettuce (0.32 ppm)

Vegetable, brassica, head and stem subgroup 5A 0.06 100 1 Based upon Cabbage 0.06 ppm)

Vegetable, brassica, leafy, group 5B 0.71 100 1 Based upon residues in leaf lettuce, which better represents

residues on leafy Brassica than does cabbage.

Vegetable, legume, group 6 Vegetable, legume, edible

podded, subgroup 6A 0. 73 100 1 based on the average residues in succulent beans (0. 39 ppm)

Pea and bean, succulent shelled, subgroup 6B 0. 39 100 1 Average residues in succulent peas (0. 73 ppm)

Pea and bean, dried shelled, subgroup 6C 0.11 32 1 dried beans (0.1 1 ppm)

Soybean seed 0.034 9 1 soybeans (0.0 34 ppm)

Soybean flour 0.034 9 1 soybeans (0.0 34 ppm)

Soybean milk 0.034 9 1 soybeans (0.0 34 ppm)

Soybean oil 0.034 9 0.005 soybeans (0.0 34 ppm)

Vegetable, fruiting, group 8 0.025 100 1 Based on average residues in tomatoes ( 0.025 ppm) , and

factors from processing study. DEEM default factor for juice

and dried tomato Tomato Paste 100 3.3

Tomato Puree 100 2.1

Tomato Juice 100 1.5

Dried tomato 0.025 100 14.3

Okra 0.025 100 1 From Tomato (0.025 ppm)

Vegetable, cucurbit, group 9 0.5 100 1 Based on average residues in cucumbers (0.74 ppm)

Watermelon 0.5 3 3 1 Residues from cucurbits

Fruit, citrus, group 10 0.024 100 1 Based on average residues in oranges (<0.05 ppm)

Citrus Fruit Oil 0.024 100 0.2 Citrus oil factor

Orange Juice 0.024 100 0.7

Other Citrus Fruit Juices 0.024 100 0.7

adjusted From OJ factor , adjusted to other citrus using DESAC

adjustment factors

Citrus Peels 0.024 100 1.0 Between oil factor and pulp factor

Fruit, pome, group 11 0.041 100 1 Based on average residues in apples ( 0.041 ppm)

Fresh apples 0.041 7 6

Dried apple 0.041 37 8.0 Default factor

Apple sauce 0.041 1 4 1 No Factor

Apple juice 0.041 4 0 1.2 Processing Study

Pear/ Other Pome fruit juice 0.041 100 1.2

### Page 5 of 30

Table 1

. Residue Summary for Endothall.

Commodity Residue

s (ppm) Percent Crop

Treated Processing

Factor Comments

Dried pear 0.041 100 6.25 Default Factor

Fruit, stone, group 12 0.098 100 1 Based on average residues in peaches (0.15 ppm)

Dried Peach 0.098 100 7.0 Default factor

Dried Plum (Prune) 0.098 100 5.0 Default factor

Prune Juice 0.098 100 1.4 Default factor

Cherry Juice 0.098 100 1.5 Default factor

Caneberry subgroup 13A 0. 33 100 1 blackberries (0.33 ppm)

Bushberry subgroup 13B 0. 18 100 1 Based on residues in blueberries (0.18 ppm)

Current, dried 0.33 100 4.4 Raisin drying factor

Fresh Grape 0.52 9 9 1 Based upon average residues on grapes ( 0. 52 ppm)

Grape Juice 0.52 9 4 1. 2 R esidues on grapes , Default Factor

Grape, raisin 0.52 9 4 4.4 Average residues of 0.52 ppm in grapes and a 4.4x processing

factor.

Grape Leaves 0.52 9 9 1 Based upon average residues on grapes

Grape wine and sherry 0.52 9 4 1.2 Based upon average residues on grapes, and default juice

processing factor

Nut, tree, group 14 0.031 100 1 Based on average residues in almond nutmeats (0.0 31 ppm).

Pecans 0.024 100 1 Pecan Study

Tree nut oils 0.031 100 0.005 Processing factor from soybean oil factor

Grain, cereal, group 15 0.71 100 1 Cereal Grain

– corn, sorghum and wheat field trials

Wheat 0.71 14 1 Wheat field studies

Wheat flour 0.71 14 0.6 Wheat Processing Study

Wheat germ 0.71 14 2.6 processing factor of 2.6x for germ,

Wheat Bran 0.71 14 2.3 PF 2.3x for bran,

Barley, grain 0.71 36 1 From wheat

Barley, flour 0.71 36 1 Wheat residues corn flour processing

Barley, bran 0.71 36 2.3 Wheat processing study

Sorghum, grain 1.0 15 1.0 Percent irrigated for grain only

Sorghum, syrup 1.0 100 1.0 Percent irrigated for grain only

Oats 0.71 7 1.0 Residues from wheat

Corn, sweet, kernel plus cob with husks removed 0.11 100 1 Tolerance based on average residues in sweet corn K+CWHR

(0.1 1 ppm)

Corn, field, grain 0.05 19 1 Tolerance based on average residues found in field corn grain

(0.05 ppm)

Corn meal and flour 0.05 19 1.0 Corn Processing Study

Corn, field, bran 0.05 19 2.3 Corn Processing Study

Corn, field, starch 0.05 19 1.0 Corn Processing Study

Corn, field, syrup 0.05 19 1.5 DEEM Default

Corn, field, oil 0.05 19 1 Corn Processing Study

Corn, pop, grain 0.05 19 1 Tolerance based on average residues found in field corn grain

(0.05 ppm)

Herb and spice, group 19 100 1 Based upon Mint Study

Rice, grain 1.05 100 1 Average residues in Rice

White Rice 1.05 100 0.1 Rice Processing Study

Rice Bran 1.05 100 2.3 Rice Processing Study

Rice flour 1.05 100 0.1 Rice Processing Study for white rice

Alfalfa 0.11 100 1 From Alfalfa trials

Acerola 0.041 100 1 Translated from apple residues

Amar a nth 0.71 100 1 Translated from leaf lettuce

Artichoke 0.71 100 1 Translated from leaf lettuce

Asparagus 0.32 100 1 Translated from head lettuce

### Page 6 of 30

Table 1

. Residue Summary for Endothall.

Commodity Residue

s (ppm) Percent Crop

Treated Processing

Factor Comments

Avocado 0.041 100 1 Translated from apple residues

Bamboo 2.2 100 1 From average grass residues

Banana 0.041 100 1 Translated from apple residues

Dried Banana 0.041 100 3.9 Translated from apple residues

Belgium endive 0.32 100 1 Translated from head lettuce

Breadfruit 0.041 100 1 Translated from apple residues

Cactus 0.71 100 1 Translated from leaf lettuce

Canistel 0.041 100 1 Translated from apple residues

Carob 0.041 100 1 Translated from apple residues

Cherimoya 0.041 100 1 Translated from apple residues

Cocoa bean 0.041 100 1 Translated from apple residues

Cocoa bean powder 0.041 100 1 Translated from apple residues

Coconut meat 0.041 100 1 Translated from apple residues

Dried coconut meat 0.041 100 2.1 Translated from apple residues

Coconut milk 0.041 100 1 Translated from apple residues

Coconut oil 0.041 100 0.005 Translated from apple residues and soy oil PF

Coffee, roasted bean 0.041 100 1 Translated from apple residues

Coffee, Instant 0.041 100 1 Translated from apple residues

Cottonseed oil 0.1 100 0.00 5 Regular Cotton residues and soy processing factor

Cranberry 0.33 100 1 From black berries

Cranberry, Dried 0.33 100 1 From black berries

Cranberry, Juice 0.33 100 1.1 From black berries

Date 0.041 100 1 Translated from apple residues

Feijoa 0.041 100 1 Translated from apple residues

Fig 0.041 100 1 Translated from apple residues

Dried fig 0.041 100 1 Translated from apple residues

Flaxseed Oil 0.034 100 0.005 From soybeans and the soy oil PF

Guava 0.041 100 1 Translated from apple residues

Honey 0.003 100 1 Use milk residues

Hop 0.1 100 1 Tolerance from Terrestrial use

Jaboticaba 0.041 100 1 Translated from apple residues

Jack fruit 0.041 100 1 Translated from apple residues

Kiwi fruit 0.52 100 1 From grapes

Longan 0.041 100 1 Translated from apple residues

Lychee 0.041 100 1 Translated from apple residues

Lychee, dried 0.041 100 1.85 Translated from apple residues , DEEM default PF

Mamey apple 0.041 100 1 Translated from apple residues

Mango 0.041 100 1 Translated from apple residues

Dried mango 0.041 100 1 Translated from apple residues

Mango juice 0.041 100 1 Translated from apple residues

Maple sugar 0.041 100 1 Translated from apple residues

Maple syrup 0.041 100 1 Translated from apple residues

Mulberry 0.041 100 1 Translated from apple residues

Mushroom 0.71 100 1 Translated from leaf lettuce

Olive 0.041 100 1 Translated from apple residues

Olive oil 0.041 100 0.005 Translated from apple residues and soy PF

Palm heart 2.2 100 1 Translated from grass residues

### Page 7 of 30

Table 1

. Residue Summary for Endothall.

Commodity Residue

s (ppm) Percent Crop

Treated Processing

Factor Comments

P a lm oil 2.2 100 0.005 Translated from grass residues

Papaya 0.041 100 1 Translated from apple residues

Dried papaya 0.041 100 1.8 Translated from apple residues

Papaya juice 0.041 100 1.5 Translated from apple residues

Passionfruit 0.041 100 1 Translated from apple residues

Passionfruit juice 0.041 100 1 Translated from apple residues

Pawpaw 0.041 100 1 Translated from apple residues

Peanut 0.08 42 1 From potato residues

Peanut butter 0.08 42 1 .89 From potato residues

Peanut oil 0.08 42 0.005 From potato residues, with soy oil processing factor

Peppermint 2.14 100 1 From Mint Study

Peppermint oil 2.14 100 0.0 0 1 From Mint Study

Persimmon 0.041 100 1 Translated from apple residues

Pine nut 0.041 100 1 Translated from apple residues

Pineapple 0.5 100 1 From curcubits

Dried pineapple 0.5 100 5.0 From curcubits

Pineapple juice 0.5 100 1.7 From curcubits

Plantain 0.041 100 1 Translated from apple residues

Dried plantain 0.041 100 3.9 Translated from apple residues

Pomegranate 0.041 100 1 Translated from apple residues

Psyllium seed 0.71 100 1 Translated from leaf lettuce

Quinoa gra oil in 0.71 100 1 Translated from leaf lettuce

Rapeseed 0.034 100 0.005 From Soybeans and soybean oil PF

Safflower seed oil 0.034 100 0.005 From Soybeans and soybean oil PF

Sapote 0.041 100 1 Translated from apple residues

Sesame seed 0.71 100 1 Translated from leaf lettuce

Sesame seed oil 0.71 100 0.005 Translated from leaf lettuce

Soursop 0.041 100 1 Translated from apple residues

Spanish lime 0.041 100 1 Translated from apple residues

Spearmint 2.14 100 1 From Mint Study

Spearmint 2.14 100 0.001 From Mint Study

Sunflower 0.034 100 0.005 From Soybeans and soybean oil PF

Spearmint oil 2.14 100 0.01 From Mint Study

Starfruit 0.041 100 1 Translated from apple residues

Strawberry 0. 52 90 1 Translated from grapes

Strawberry juice 0. 52 100 1 Translated from grapes

Sugar apple 0.041 100 1 Translated from apple residues

Sugarcane 2.2 100 1 From grass

Sugarcane sugar 2.2 54 0 From grass, processed to zero residues

Sugarcane molasses 2.2 54 2.4 From grass, sugar beet to molasses processing factor

Tamarind 0.041 100 1 Translated from apple residues

Tea, dried 0. 33 100 1 Translated from blackberry residues

Instant tea 0.33 100 1 Translated from blackberry residues

Tomato tree 0.041 100 1 Translated from apple residues

Vinegar 0.025 100 1 Translated from apple residues

Water chestnut 5.0 100 1 Aquatic plant, highest residue value in water

Watercress 5.0 100 1 Aquatic plant, highest residue value in water

Cattle, muscle 0.0025 100 1 Based upon calculations for Dairy Cattle using metabolism

data.

### Page 8 of 30

Table 1

. Residue Summary for Endothall.

Commodity Residue

s (ppm) Percent Crop

Treated Processing

Factor Comments

Cattle, meat byproducts 0.023 100 1 Based upon calculations for Dairy Cattle using metabolism

data.

Cattle, kidney 0.023 100 1 Based upon calculations for Dairy Cattle using metabolism

data.

Cattle, liver 0.010 100 1 Based upon calculations for Dairy Cattle using metabolism

data.

Cattle, fat 0.001 100 1 Based upon calculations for Dairy Cattle using metabolism

data.

Milk 0.003 100 1 Based upon calculations for Dairy Cattle using metabolism

data.

Sheep, muscle 0.002 100 1 Based upon calculations for Beef Cattle using metabolism

data.

Sheep, kidney 0.014 100 1 Based upon calculations for Beef Cattle using metabolism

data.

Sheep, liver 0..006 100 1 Based upon calculations for Beef Cattle using metabolism

data.

Sheep, fat 0.0006 100 1 Based upon calculations for Beef Cattle using metabolism

data.

Goat, muscle 0.0015 100 1 Based upon calculations for Beef Cattle using metabolism

data.

Goat, kidney 0.014 100 1 Based upon calculations for Beef Cattle using metabolism

data.

Goat, liver 0.006 100 1 Based upon calculations for Beef Cattle using metabolism

data.

Goat, fat 0.0006 100 1 Based upon calculations for Beef Cattle using metabolism

data.

Hog, muscle 0.0007 100 1 Based upon calculations using metabolism data.

Hog, Skin 0.0065 100 1 Based upon calculations using metabolism data.

Hog, kidney 0.0065 100 1 Based upon calculations using metabolism data.

Hog, liver 0.0028 100 1 Based upon calculations using metabolism data.

Hog, fat 0.0003 100 1 Based upon calculations using metabolism data.

Poultry, muscle 0.001 100 1 Based upon calculations using metabolism data.

Poultry, liver 0.003 100 1 Based upon calculations using metabolism data.

Poultry, fat 0.001 100 1 Based upon calculations using metabolism data.

Poultry, skin and meat byproducts 0.014 100 1 Based upon calculations using metabolism data.

Egg, whole 0.0037 100 1 Based upon calculations using metabolism data.

Egg, white 0.0003 100 1 Based upon calculations using metabolism data.

Egg, yolk 0.0037 100 1 Based upon calculations using metabolism data.

Finfish 0.1 100 1 Tolerance

Crustaceans 1 100 1 Recommended Tolerance

Mollusks 4 100 1 Recommended Tolerance



## Acute and Cancer Dietary Exposure

No acute or cancer dietary exposure endpoints were determined, so no acute or chronic exposure

assessment has been performed.

Chronic Dietary Exposure Results and Characterization

Based upon a DEEM chronic exposure analysis for food plus water, neither the general U.S.

population nor any of its subgroups exceeded the chronic population adjusted dose (cPAD). In this

assessment the general U.S. population is estimated to be exposed at 0.0022 2 9 mg/Kg bw/day or

### Page 9 of 30



## 3 2 % of the cPAD. The most highly exposed population subgroup is children 1

– 2 years of age,

who are estimated to be exposed at 0.00 6314 mg/Kg bw/day or 90 .0% of the cPAD.

III. Drinking Water Data

The value for (human) drinking water residues, at 31 ppm, that was used in the dietary risk

assessment was provided by the Environmental Fate and Effects Division (EFED) (09/18/2012, DP

404321)

. Water residues were incorporated in the DEEM

- FCID into the food categories “water,

direct, all sources” and “water, indirect, all sources.”

As expla ined by EFED, t his is a terrestrial food use. Considering the possible exposure of

drinking water, the greatest potential will come from the direct application to drinking water

reservoirs. In a previous drinking water assessment, EFED has concluded the us e of endothall

treated irrigation water represents the most conservative estimates for drinking water

assessment (DP 356316, dated September 9, 2009, see attachment). Therefore, the drinking

water exposure estimates (shown below) based on the direct wate r applications should

continue to be used for the human health risk assessment.

T he maximum potential exposure of endothall in drinking water sources is expected to result from

the direct application of endothall to drinking water reservoirs to control aq uatic weeds. EFED

assumed that the entire reservoir would be treated at the maximum rates, with no more than 10% of

the reservoir treated at one time as stated on the label, so that 10 treatments were applied 7 days

apart to get the entire reservoir. Sin ce the label specified that the community water system (CWS)

could not supply treated drinking water unless the residues were below 0.1 ppm (100 μ g/L), EFED

assumed 100 μ g/L (0.1 ppm) as the acute (peak) exposure and the constant exposure during the

treatm ent period and then modeled residue decline by degradation after the final treatment. This

resulted in a chronic (annual average) concentration of 31 μ g/L (0.031 ppm) for endothall. This

represents the likely high

- end chronic exposure from endothall from the use most likely to generate

the highest exposures (treatment of a reservoir). ”

IV. DEEM

- FCIDTM Program and Consumption Information

Endothall chronic dietary exposure assessments was conducted using the Dietary Exposure

Evaluation Model software with the Food Commodity Intake Database DEEM

- FCIDTM, Version

3.16 which incorporates consumption data from USDA’s National Health and Nutrition

Examination Survey)/“What We Eat in America” (NHANES/WWEIA) dietary survey conducted in

2003

- 2008 . The 2003

- 2008 data are based on the reported consumption of more than 20,000

individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked

to EPA

- defined food commodities (e.g. apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat

flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed

jointly by USDA/ARS and EPA. For chro nic exposure assessment, consumption data are averaged

for the entire U.S. population and within population subgroups, but for acute exposure assessment

are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA

consumption da ta, which took into account dietary patterns and survey respondents, HED concluded

that it is most appropriate to report risk for the following population subgroups: the general U.S.

population, all infants (<1 year old), children 1

- 2, children 3

- 5, childr en 6

- 12, youth 13

- 19, adults

20

- 49, females 13

- 49, and adults 50+ years old.

### Page 10 of 30



## For chronic dietary exposure assessment, an estimate of the residue level in each food or food

- form

(e.g., orange or orange juice) on the food commodity residue list is multiplie d by the average daily

consumption estimate for that food/food form to produce a residue intake estimate. The resulting

residue intake estimate for each food/food form is summed with the residue intake estimates for all

other food/food forms on the commod ity residue list to arrive at the total average estimated

exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This

procedure is performed for each population subgroup.

V. Toxicological Information

The HIARC discussed endothall on 18 May 2004. This discussion resulted in the following table of

toxicological endpoints for endothall. No revisions were considered necessary for the current

assessment.

Table 2. Summary of Toxicological Doses and Endpoints for Endothall for Use in Dietary Exposure Assessment

Exposure

Scenario Point of Departure Uncertainty/FQPA

Safety Factors RfD, PAD, Level

of Concern Study and Toxicological

Effects

Acute Dietary An appropriate endpoint attributable to a single dose was not available from any study, including the

prenatal developmental toxicity study in rats. An acute RfD was not established.

Chronic Dietary

(All

populations) LOAEL= 2 mg/kg/day UF A 

### = 10

UF H 

### = 10

UF DB 

### = 3

UF total 

### = 300 Chronic RfD =

0.007 mg/kg/day



### cPAD = 0.007

mg/kg/day 2

- generation reproduction

study in rats; LOAEL = 2

mg/kg/day based on

proliferative lesions of the

gastric epithelium in both

sexes

Cancer (oral,

dermal,

inhalation) Not likely to be carcinogenic to humans



### Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human

exposures. LOAEL = lowes t observed adverse effect level. UF = uncertainty factor. UF A 

### = extrapolation from animal

to human (intraspecies). UF H 

### = potential variation in sensitivity among members of the human population

(interspecies). UF DB 

### = to account for the absence of key d ata (i.e., lack of a critical study). PAD = population adjusted

dose (a = acute, c = chronic). RfD = reference dose.



## VI. Results/Discussion

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the

cPAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the U.S. population and

various population subgroups. The results reported in Table 3 are for the general U.S. Population,

all infants (<1 year old), non

- nursing infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12,

youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

Results of Chronic Dietary (Food Only, Food and Drink ing Water, and Drinking Water Only)

Exposure Analysis

The results of the chronic dietary exposure analysis are reported in the summary table (Table 3)

below. We again note that these estimates are expected to be very conservative, but that data is not

available to provide specific, quantifiable refinement below these levels of exposure.

### Page 11 of 30

Table 3. Summary of Chronic Dietary ( Food and Drinking Water) Exposure and Risk for Endothall

Population Subgroup Chronic Dietary

Food Plus Water

Dietary Exposure (mg/kg/day) % cPAD

General U.S. Population 0.002229 32

All Infants (< 1 year old) 0.004392 63

Children 1

- 2 years old 0.006314 90

Children 3

- 5 years old 0.004575 65

Children 6

- 12 years old 0.002554 37

Youth 13

- 19 years old 0.001483 21

Adults 20

- 49 years old 0.001932 28

Adults 50

- 99 years old 0.001983 28

Females 13

- 49 years old 0.001874 27



## VII. Characterization of Inputs/Outputs

In the course of conducting a dietary exposure analysis, decisions are made regarding the residue

data used in the analysis (e.g., field trials, monitoring data, etc.), refinements incorporated into the

analysis (such as percent crop treated and processing factors), and perhaps other issues. The

following is a description of the most important aspects of these unc ertainties.

Level of Refinement

Residue and processing data are all from residue field trials designed to produce maximum residues

for the purpose of setting tolerances. The assessment has been refined as possible given the nature

of the information a vailable. Average residue values, not tolerances, have been used for the crops.

Where information was available to BEAD, percents of the harvested crop that have been irrigated

(in lieu of percent crop treated values) have also been incorporated. For es timating residues in

meat, milk, poultry and eggs, average residues in feeds and the maximum allowed 5 ppm in the

livestock water were used. In general these assessment results are very conservative.

Residue Issues

The estimate of endothall residues in drinking water is conservative and is expected to represent the

high end of reasonably possible, chronically available residues in drinking water. The assessment

incorporates the assumption that all drinking water con sumed by all exposed individuals chronically

contains residues at this concentration.

### Page 12 of 30



## The estimated exposures through food incorporate the conservative assumptions that all irrigation

systems are treated with endothall; that the treatments are always at the maximum rate and are

applied the maximum number of times per season. It appears that very many, if not all, irrigation

channels do require some form of treatment to remove aquatic weeds every year, but it is not now

known to what extent endothall may find future use to address these problems.

All treatments in the field trials are by overhead irrigation (i.e. are sprayed on the crops). This

method delivers the treated water directly to the surfaces of the crops as well as to the roots

compared to other irrigation methods that deliver water only to the roots but it is unclear to what

extent overhead irrigation may be conservative.

It is assumed that all meat, milk, poultry, and eggs derive from livestock and poultry that have been

consuming both water and feeds that contain the maximum possible endothall residues and that fish

consumed have been swimming in endothall treated water and have incurred tolerance level

residues. Residues are also postulated to be present in honey at the concentrations found in cow’s

milk. The conservatism of estimating exposure through all of these foods all together should be

apparent, but cannot be quantified.

Thus it is again summarized that the residue assumptions are expected to be conservative , but the

extent of these conservatisms cannot be well estimated.

Translation of Residue Data

As previously stated, because residues must be assumed for all possible crops in the

USA, residues have been widely translated between crops both inside and outside of crop groups

because only a few more representative crops were tested in the field trials. The data for each of the

tested crops was very limited as well. The limited crop processing data have also been extrapolated

to other crops. Although it is certainly po ssible to question individual translations, and values for

each crop are uncertain, it is believed that, when averaged over the total, the results are less

uncertain because there is a fairly large amount of reasonably consistent data overall. Therefore,

these translations should provide reasonable but conservative estimates of the chronic exposure to

residues.

Processing Factors

As also previously stated, the limited processing data from these studies were translated to the

important processed commoditi es of all crops. Where data was not available, DEEM default factors

were used if they were available. For processed commodities where even DEEM default factors

were not available, the factors were generally set to 1

. No washing, peeling or cooking data were

available and none were incorporated into this assessment.

Adequacy of %CT data

There is no way to establish ordinary percent crop treated values for this use. In lieu of that

information BEAD has provided percent of the harvested crop that has b een irrigated , assuming

that all irrigation water is treated. The assessment is conservative to the extent that endothall will

only be used on some irrigation canals some of the time. However, at this time it has not been

### Page 13 of 30



## possible to estimate the proport ion of canals that will be treated, and this new use does have the

potential to become extensive.

Significant Risk Contributors ("Risk Drivers")

The most significant risk drivers for children are commodities from grapes

– table grapes, grape

juice and raisins. The largest proportion of this exposure is from grape juice. Exposure through

drinking water is very important for infants, and especially for non

- nursing infants. Potential

residues in milk were also a possible driver of exposure for infants. For older children, wheat, oats,

strawberries and pineapple juice become notable sources of potential residues. Pineapples are not

grown in the continental U.S., but the use was retained in this exposure assessment to avoid

unnecessarily limiting the po tential use of endothall. (Note also that residues were not measured on

pineapples. These residues were translated from cucurbits.) Many other tropical fruits are also

grown in the continental U.S. to only a very limited extent, but were retained in the assessment

because small acreages of many of these crops are grown along the southernmost regions and so

could not be removed. Thus this assessment also does not assume that use will be restricted from

any of the tropical islands of the U.S.

VIII. Conclusions

HED has no toxic endpoints for acute or cancer exposures to endothall. In a conservative chronic

DEEM assessment, it has been shown that exposures to endothall from use on apple is below the

cPAD, HED’s level of concern, for the general U.S. population and for all of its subgroups. The

general U.S. population is estimated to be exposed at not more than 3 2 % of the cPAD. The most

highly exposed population subgroup is children 1

– 2 years old , who may be exposed at not more

than 90 % of the cPAD

The uncertainty and conservativeness of these estimates cannot be quantified, but can be

qualitatively characterized in some detail as discussed above. The assessment is conservative on

man y counts and actual exposures are expected to be below those calculated. However, although

the various factors discussed are expected to be conservative, OPP has no way to quantify the extent

to which they are conservative, individually or combined.

IX. List of Attachments

1) Chronic Food Plus Water Residue Input file ( Commodity Code order )

2) Chronic Results files: Food Plus Water

3) Percent Crop Treated Memo from BEAD

### Page 14 of 30

Attachment 1. Chronic Food Plus Water Input File ( Commodity Code order )

Filename: C: \ Documents and Settings \ stadayon \ My Documents \ Work in

Progress \ Endothall \ ENDOTHALL12DEC2012.R08

Chemical: endothall

RfD(Chronic): .007 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 12

- 12

- 2012/06:41:12 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodit y Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 0.330000 1.000 1.000

0101050001 1AB Beet, garden, roots

- babyfood 0.330000 1.000 1.000

0101053000 1A Beet, sugar, molasses 0.330000 2.400 0.370

0101053001 1A Beet, sugar, molasses

- babyfood 0.330000 2.400 0.370

0101067000 1AB Burdock 0.330000 1.000 1 .000

0101078000 1AB Carrot 0.080000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.080000 1.000 1.000

0101079000 1AB Carrot, juice 0.080000 1.000 1.000

0101084000 1AB Ce leriac 0.330000 1.000 1.000

0101100000 1AB Chicory, roots 0.330000 1.000 1.000

0101168000 1AB Ginseng, dried 0.330000 1.000 1.000

0101190000 1AB Horseradish 0.330000 1.000 1.000

0101250000 1AB Parsley, turnip rooted 0.330000 1.000 1.000

0101251000 1AB Parsnip 0.330000 1.000 1.000

0101251001 1AB Parsnip

- babyfood 0.330000 1.000 1.000

0101314000 1AB Radish, roots 0.330000 1.000 1.000

0101316000 1AB Radish, Oriental, roots 0.330000 1.000 1.000

0101327000 1AB Rutabaga 0.330000 1.000 1.000

0101331000 1AB Salsify, roots 0.330000 1.000 1.000

0101388000 1AB Turnip, roots 0.330000 1.000 1.000

0103015000 1CD Arrowroot, flour 0.330000 6.500 1.000 PF fro

Full comment: PF from p otato

0103015001 1CD Arrowroot, flour

- babyfood 0.330000 6.500 1.000 PF fro

Full comment: PF from potato

0103017000 1CD Artichoke, Jerusalem 0.330000 1.000 1.000

0103082000 1CD Cassava 0.330000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.330000 1.000 1.000

0103139000 1CD Dasheen, corm 0.330000 1.000 1.000

0103166000 1CD Ginger 0.330000 1.000 1.000

0103166001 1CD Ginger

- babyfood 0.330000 1.000 1.000

0103167000 1CD Ginger, dried 0.330000 1.000 1.000

0103296000 1C Potato, chips 0.080000 1.000 1.000

0103297000 1C Potato, dry (granules/ flakes) 0.080000 6.500 1.000

0103297001 1C Potato, dry (granules/ flakes)

- b 0.080000 6.500 1.000

0103298000 1C Potato, flour 0.080000 6.500 1.000

0103298001 1C Potato, flour

- babyfood 0.080000 6.500 1.000

0103299000 1C Potato, tuber, w/peel 0.080000 1.000 1.000

0103299001 1C Potato, tuber, w/peel

- babyfood 0.080000 1.000 1.000

0103300000 1C Potato, tuber, w/o peel 0.080000 1.000 1.000

0103300001 1C Potato, tuber, w/o peel

- babyfood 0.080000 1.000 1.000

0103366000 1CD Sweet potato 0.330000 1.000 1.000

0103366001 1CD Sweet potato

- babyfood 0.330000 1.000 1.000

0103371000 1CD Tanier, corm 0.330000 1.000 1.000

0103387000 1CD Turmeric 0.330000 1.000 1.000

0103406000 1CD Yam, true 0.330000 1.000 1.00 0

0103407000 1CD Yam bean 0.330000 1.000 1.000

0200051000 2 Beet, garden, tops 1.300000 1.000 1.000

0200101000 2 Chicory, tops 1.300000 1.000 1.000

0200140000 2 Dashe en, leaves 1.300000 1.000 1.000

0200315000 2 Radish, tops 1.300000 1.000 1.000

0200317000 2 Radish, Oriental, tops 1.300000 1.000 1.000

0200332000 2 Salsify, tops 1.300000 1.000 1.000

0301165000 3A Garlic, bulb 0.050000 1.000 1.000

0301165001 3A Garlic, bulb

- babyfood 0.050000 9.000 1.000

0301237000 3A Onion, bulb 0.050000 1.000 1.000

0301237001 3A Onion, bulb

- babyfood 0.050000 1.000 1.000

0301238000 3A Onion, bulb, dried 0.050000 9.000 1.000

0301238001 3A Onion, bulb, dried

- babyfood 0.050000 9.000 1.000

### Page 15 of 30

0302103000 3B C hive, fresh leaves 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

0302198000 3B Leek 0.260000 1.000 1.000 from g

Full comment: from green onion

0302239000 3B Onion, green 0.260000 1.000 1.000

0302338500 3B Shallot, fresh leaves 0.050000 1.000 1.000

0401005000 4A Amaranth, leafy 0.710000 1.000 1.000

0401018000 4A Arugula 0.710000 1.000 1.000

0401104000 4A Chrysanthemum, garland 0.710000 1.000 1.000

0401133000 4A Cress, garden 0.710000 1.000 1.000

0401134000 4A Cress, upland 0.710000 1.00 0 1.000

0401138000 4A Dandelion, leaves 0.710000 1.000 1.000

0401150000 4A Endive 0.320000 1.000 1.000 from h

Full comment: from head lettuce

0401204000 4A Lettuce, head 0.320000 1.000 1.000 from h

Full comment: from head lettuce

0401205000 4A Lettuce, leaf 0.710000 1.000 1.000

0401248000 4A Parsley, leaves 0.710000 1.000 1.000

0401313000 4A Radicchio 0.710000 1.000 1.000

0401355000 4A Spinach 0.710000 1.000 1.000

0401355001 4A Spinach

- babyfood 0.710000 1.000 1.000

0402076000 4B Cardoon 0.710000 1.000 1.000

0402085000 4B Celery 0.320000 1.000 1.000 from h

Full comment: from head lettuce

0402085001 4B Celery

- babyfood 0.320000 1.000 1.000 from h

Full comment: from head lettuce

0402086000 4B Celery, juice 0.320000 1.000 1.000 from h

Full comment: from head lettuce

0402087000 4B Celtuce 0.710000 1.000 1.000

04021520 00 4B Fennel, Florence 0.710000 1.000 1.000

0402322000 4B Rhubarb 0.320000 1.000 1.000 from h

Full comment: from head lettuce

0402367000 4B Swiss chard 0.710000 1.000 1.000

0501061000 5A Broccoli 0.060000 1.000 1.000 from c

Full comment: from cabbage

0501061001 5A Broccoli

- babyfood 0.060000 1.000 1.000 from c

Full comment: from cab bage

0501062000 5A Broccoli, Chinese 0.060000 1.000 1.000 from c

Full comment: from cabbage

0501064000 5A Brussels sprouts 0.060000 1.000 1.000 from c

Full comment: from cabbage

0501069 000 5A Cabbage 0.060000 1.000 1.000

0501071000 5A Cabbage, Chinese, napa 0.060000 1.000 1.000 from c

Full comment: from cabbage

0501072000 5A Cabbage, Chinese, mustard 0.060000 1. 000 1.000 from c

Full comment: from cabbage

0501083000 5A Cauliflower 0.060000 1.000 1.000 from c

Full comment: from cabbage

0501196000 5A Kohlrabi 0.060000 1.000 1.000 from c

Full comment: from cabbage

0502063000 5B Broccoli raab 0.710000 1.000 1.000 from l

Full comment: from leaf lettuce

0502070000 5B Cabbage, Chinese, bok choy 0.710000 1.000 1.000 from l

Full comment: from leaf lettuce

0502117000 5B Collards 0.710000 1.000 1.000 from l

Full comment: from leaf lettuce

0502194000 5B Kale 0.710000 1.000 1.000 from l

Full comment: from leaf lettuce

0502229000 5B Mustard greens 0.710000 1.000 1.000 from l

Full comment: from leaf lettuce

0502318000 5B Rape greens 0.710000 1.000 1.000 from l

Full comment: from leaf lettuce

0502389000 5B Turnip, greens 0.710000 1.000 1.000 from l

Full comment: from leaf lettuce

0600347000 6 Soybean, seed 0.034000 1.000 0.090

0600349000 6 Soybean, soy milk 0.034000 1.000 0.090

0600349001 6 Soybean, soy milk

- babyfood or in 0.034000 1.000 0.090

0600350000 6 Soybean, oil 0.034000 0.005 0.090

0600350001 6 Soybean, oil

- babyfood 0.034000 0.005 0.090

0601043000 6A Bean, snap, succulent 0.390000 1.000 1.000

0601043001 6A Bean, snap, succulent

- babyfood 0.390000 1.000 1.000

0601257000 6A Pea, edible podded, succulent 0.730000 1.000 1.000

### Page 16 of 30

0602031000 6B Bean, broad, succulent 0.390000 1.000 1.000

0602033000 6B Bean, cowpea, succulent 0.390000 1.000 1.000

0602037000 6B Bean, lima, succulent 0.390000 1.000 1.000

0602255000 6B Pea, succulent 0.730000 1.000 0.110

0602255001 6B Pea, succulent

- babyfood 0.730000 1.000 0.110

0602259000 6B Pea, pigeon, succulent 0.390000 1.000 0.110

0603030000 6C Bean, black, seed 0.110000 1.000 0.320

0603032000 6C Bean, broad, seed 0.110000 1.000 0.320

0603034000 6C Bean, cowpea, seed 0.110000 1.000 0.320

0603035000 6C Bean, great northern, seed 0.110000 1.000 0.320

0603036000 6C Bean, kidney, seed 0.110000 1.000 0.320

0603038000 6C Bean, lima, seed 0.110000 1.000 1.000

0603039000 6C Bean, mung, seed 0.110000 1.000 0.320

0603040000 6C Bean, navy, seed 0.110000 1.000 0.320

0603041000 6C Bean, pink, seed 0.110000 1.000 0.320

0603042000 6C Bean, pinto, seed 0.110000 1.000 0.320

0603098000 6C Chickpea, seed 0.110000 1.000 0.320

0603098001 6C Chickpea, seed

- babyfood 0.110000 1.000 0.320

0603099000 6C Chickpea, flour 0.110000 1.000 0.320

0603182000 6C Guar, seed 0.110000 2.100 0.320

0603182001 6C Guar, seed

- babyfood 0.110000 2.100 0.320

0603203000 6C Lentil, seed 0.110000 1.000 1.000

0603256000 6C Pea, dry 0.110000 1.000 1.000

0603256001 6C Pea, dry

- babyfood 0.110000 1.000 1.000

0603258000 6C Pea, pigeon, seed 0.110000 1.000 1.000

0603348000 6C Soybean, flour 0.034000 1.000 0.090

0603348001 6C Soybean , flour

- babyfood 0.034000 1.000 0.090

0801374000 8A Tomatillo 0.025000 1.000 1.000 from t

Full comment: from tomato 1/2 LOD

0801375000 8A Tomato 0.025000 1.000 1.00 0 from t

Full comment: from tomato 1/2 LOD

0801375001 8A Tomato

- babyfood 0.025000 1.000 1.000 from t

Full comment: from tomato 1/2 LOD

0801376000 8A Tomato, paste 0.025000 3.300 1. 000 from t

Full comment: from tomato 1/2 LOD

0801376001 8A Tomato, paste

- babyfood 0.025000 3.300 1.000 from t

Full comment: from tomato 1/2 LOD

0801377000 8A Tomato, puree 0.025000 2.100 1.000 from t

Full comment: from tomato 1/2 LOD

0801377001 8A Tomato, puree

- babyfood 0.025000 2.100 1.000 from t

Full comment: from tomato 1/2 LOD

0801378000 8A Tomato, dried 0.025000 14.300 1.000 from t

Full comment: from tomato 1/2 LOD

0801378001 8A Tomato, dried

- babyfood 0.025000 14.300 1.000 from t

Full comment: from tomato 1/2 LOD

0801379000 8A Tomato, juice 0.025000 1.5 00 1.000 from t

Full comment: from tomato 1/2 LOD

0801380000 8A Tomato, Tree 0.041000 1.000 1.000 from a

Full comment: from apples

0802148000 8BC Eggplant 0.025000 1.000 1. 000 from t

Full comment: from tomato 1/2 LOD

0802234000 8BC Okra 0.025000 1.000 1.000 from t

Full comment: from tomato 1/2 LOD

0802270000 8B Pepper, bell 0.025000 1.000 1.000 from t

Full comment: from tomato 1/2 LOD

0802270001 8B Pepper, bell

- babyfood 0.025000 1.000 1.000 from t

Full comment: from tomato 1/2 LOD

0802271000 8B Pepper, bell, dried 0.025000 1.000 1.000 from t

Full comment: from tomato 1/2 LOD

0802271001 8B Pepper, bell, dried

- babyfood 0.025000 1.000 1.000 from t

Full comment: from tomato 1/2 LOD

0802272000 8BC Pepper, nonbell 0.025000 1.0 00 1.000 from t

Full comment: from tomato 1/2 LOD

0802272001 8BC Pepper, nonbell

- babyfood 0.025000 1.000 1.000 from t

Full comment: from tomato 1/2 LOD

0802273000 8BC Pepper, nonbell, dried 0.025000 1 .000 1.000 from t

Full comment: from tomato 1/2 LOD

0901075000 9A Cantaloupe 0.500000 1.000 1.000

0901187000 9A Honeydew melon 0.500000 1.000 1.000

0901399000 9A Watermelon 0.500000 1.000 0.330

0901400000 9A Watermelon, juice 0.500000 1.000 0.330

0902021000 9B Balsam pear 0.500000 1.000 1.000

### Page 17 of 30

0902088000 9B Chayote, fruit 0.500000 1.000 1.000

0902102000 9B Chinese waxgourd 0.500000 1.000 1.000

0902135000 9B Cucumber 0.500000 1.000 1.000

0902308000 9B Pumpkin 0.500000 1.000 1.000

0902309000 9B Pumpkin, seed 0.500000 1.000 1.000

0902356000 9B Squash, summer 0.500000 1.000 1.000

0902356001 9B Squash, summer

- babyfood 0.500000 1.000 1.000

0902357000 9B Squash, winter 0.500000 1.000 1.000

0902357001 9B Squash, winter

- babyfood 0.500000 1.000 1.000

1001106000 10A Citron 0.024000 1.000 1.000

1001107000 10A Citrus hybrids 0.024000 1.000 1.000

1001108000 10A Citrus, oil 0.024000 0.200 1.000 citrus

Full comment: citrus oil factor

1001240000 10A Orange 0.024000 1.000 1.000

1001241000 10A Orange, juice 0.024000 0.700 1.000 O J fa

Full comment: O J factor

1001241001 10A Orange, juice

- babyfood 0.024000 0.700 1.000 O J fa

Full comment: O J factor

1001242000 10A Orange, peel 0.024000 2.200 1.000 dried

Full comment: dried pulp factor

1001369000 10A Tangerine 0.024000 1.000 1.000

1001370000 10A Tangerine, juice 0.024000 0.90 0 1.000 adjust

Full comment: adjusted OJ factor

1002197000 10B Kumquat 0.024000 1.000 1.000

1002199000 10B Lemon 0.024000 1.000 1.000

1002200000 10B Lemon, juice 0.024000 0.780 1.000 adjust

Full comment: adjusted OJ factor

1002200001 10B Lemon, juice

- babyfood 0.024000 0.780 1.000 adjust

Full comment: adjusted OJ factor

1002201000 10B Lemon, peel 0.024000 2.200 1.000 dried

Full comment: dried pulp factor

1002206000 10B Lime 0.024000 1.000 1.000

1002207000 10B Lime, juice 0.024000 0.780 1.000 adjust

Full comment: adjusted OJ factor

1002207001 10B Lime, juice

- babyfood 0.024000 0.780 1.000 adjust

Full comment: adjusted OJ factor

1003180000 10C Grapefruit 0.024000 1.000 1.000

1003181000 10C Grapefruit, juice 0.024000 0.820 1.000 adjust

Full comment: adjusted OJ factor

1003307000 10C Pummelo 0.024000 1.000 1.000

1100007000 11 Apple, fruit with peel 0.041000 1.00 0 0.760

1100008000 11 Apple, peeled fruit 0.041000 1.000 0.760

1100008001 11 Apple, peeled fruit

- babyfood 0.041000 1.000 0.760

1100009000 11 Apple, dried 0.041000 8.000 0.370

1100009001 11 Apple, dried

- babyfood 0.041000 8.000 0.370

1100010000 11 Apple, juice 0.041000 1.200 0.400 juice

Full comment: juice factor

1100010001 11 Apple, juice

- babyfood 0.041000 1.200 0. 400 juice

Full comment: juice factor

1100011000 11 Apple, sauce 0.041000 1.000 0.140

1100011001 11 Apple, sauce

- babyfood 0.041000 1.000 0.140

1100129000 11 Crabapple 0.041000 1.000 1.000

1100210000 11 Loquat 0.041000 1.000 1.000

1100266000 11 Pear 0.041000 1.000 1.000

1100266001 11 Pear

- babyfood 0.041000 1.000 1.000

1100267000 11 Pear, dried 0.041000 6.250 1.000 DEEM d

Full comment: DEEM default proc factor

1100268000 11 Pear, juice 0.041000 1.200 1.000

1100268001 11 Pear, juice

- babyfood 0.041000 1.200 1.000

1100310000 11 Quince 0.041000 1.000 1.000

1201090000 12A Cherry 0.098000 1.000 1.000

1201090001 12A Cherry

- babyfood 0.098000 1.000 1.000

1201091000 12A Cherry, juice 0.098000 1.500 1.000

1201091001 12A Cherry, juice

- babyfood 0.098000 1.500 1.000

1202012000 12B Apricot 0.098000 1.000 1.000

1202012001 12B A pricot

- babyfood 0.098000 1.000 1.000

1202013000 12B Apricot, dried 0.098000 6.000 1.000 DEEM d

Full comment: DEEM default proc factor

1202014000 12B Apricot, juice 0.098000 1.000 1.000

1202014001 12B Apricot, juice

- babyfood 0.098000 1.000 1.000

1202230000 12B Nectarine 0.098000 1.000 1.000

1202260000 12B Peach 0.098000 1.000 1.000

### Page 18 of 30

1202260001 12B Peach

- babyfood 0.098000 1.000 1.000

1202261000 12B Peach, dried 0.098000 7.000 1.000

1202261001 12B Peach, dried

- babyfood 0.098000 7.000 1.000

1202262000 12B Peach, juice 0.098000 1.000 1.000

1202262001 12B Peach, juice

- babyfood 0.098000 1.000 1.000

1203285000 12C Plum 0.098000 1.000 1.000

1203285001 12C Plum

- babyfood 0.098000 1.000 1.000

1203286000 12C Plum, prune, fresh 0.098000 1.000 1.000

1203286001 12C Plum, prune, fresh

- babyfood 0.098000 1.000 1.000

1203287000 12C Plum, prune, dried 0.098000 5.000 1.000

12032870 01 12C Plum, prune, dried

- babyfood 0.098000 5.000 1.000

1203288000 12C Plum, prune, juice 0.098000 1.400 1.000

1203288001 12C Plum, prune, juice

- babyfood 0.098000 1.400 1.000

1301055000 13A Blackberry 0.330000 1.000 1.000

1301056000 13A Blackberry, juice 0.330000 1.000 1.000

1301056001 13A Blackberry, juice

- babyfood 0.330000 1.000 1.000

1301058000 13A Boysenberry 0.330000 1.000 1.000

1301208000 13A Loganberry 0.330000 1.000 1.000

1301320000 13A Raspberry 0.330000 1.000 1.000

1301320001 13A Raspberry

- babyfood 0.330000 1.000 1.000

1301321000 13A Raspberry, juice 0.330000 1.000 1.000

1301321001 13A Raspberry, juice

- babyfood 0.330000 1.000 1.000

1302057000 13B Blueberry 0.180000 1.000 1.000

1302057001 13B Blueberr y

- babyfood 0.180000 1.000 1.000

1302136000 13B Currant 0.180000 1.000 1.000

1302137000 13B Currant, dried 0.180000 1.000 1.000

1302149000 13B Elderberry 0.180000 1.000 1.000

1302174000 13B Gooseberry 0.180000 1.000 1.000

1302191000 13B Huckleberry 0.180000 1.000 1.000

1303227000 13C Mulberry 0.041000 1.000 1.000 from a

Full comment: from apples

1304175000 13D Grape 0.520000 1.000 0.950

1304176000 13D Grape, juice 0.520000 1.200 0.940 maximu

Full comment: maximum conc factor

130 4176001 13D Grape, juice

- babyfood 0.520000 1.200 0.940 maximu

Full comment: maximum conc factor

1304179000 13D Grape, wine and sherry 0.520000 1.000 0.940

1304195000 13D Kiwifruit, fuzzy 0. 520000 1.000 1.000 from g

Full comment: from grapes

1307130000 13G Cranberry 0.330000 1.000 1.000 from c

Full comment: from cane berries

1307130001 13G Cranberry

- babyfood 0.330000 1.000 1.000 from c

Full comment: from cane berries

1307131000 13G Cranberry, dried 0.330000 1.000 1.000 from c

Full comment: from cane berries

1307132000 13G Cranberry, juice 0.330000 1 .100 1.000 from c

Full comment: from cane berries

1307132001 13G Cranberry, juice

- babyfood 0.330000 1.100 1.000 from c

Full comment: from cane berries

1307359000 13G Strawberry 0.520000 1.0 00 0.900 from l

Full comment: from leafy greens

1307359001 13G Strawberry

- babyfood 0.520000 1.000 0.880 from l

Full comment: from leafy greens

1307360000 13G Strawberry, juice 0.520000 1.000 1.000 from l

Full comment: from leafy greens

1307360001 13G Strawberry, juice

- babyfood 0.520000 1.000 1.000 from l

Full comment: from leafy greens

1400003000 14 Almond 0.031000 1.000 1.000 almond

Full comment: almond field trial

1400003001 14 Almond

- babyfood 0.031000 1.000 1.000 almond

Full comment: almond field trial

1400004000 14 Almond, oil 0.031000 0.005 1.000 soy oi

Full comment: soy oil factor

1400004001 14 Almond, oil

- babyfood 0.031000 0.005 1.000 soy oi

Full comment: soy oil factor

1400059000 14 Brazil nut 0.031000 1.000 1.000 a lmond

Full comment: almond field trial

1400068000 14 Butternut 0.031000 1.000 1.000 almond

Full comment: almond field trial

1400081000 14 Cashew 0.031000 1.000 1.000 almond

Full comment: almond field trial

1400092000 14 Chestnut 0.031000 1.000 1.000 almond

### Page 19 of 30 Full comment: almond field trial

1400155000 14 Hazelnut 0.031000 1.000 1.000 almond

Full comment: almond field trial

1400156000 14 Hazelnut, oil 0.031000 0.005 1.000 soy oi

Full comment: soy oil factor

1400185000 14 Hickory nut 0.031000 1.000 1.000 al mond

Full comment: almond field trial

1400213000 14 Macadamia nut 0.031000 1.000 1.000 almond

Full comment: almond field trial

1400269000 14 Pecan 0.024000 1.000 1.000 pe can

Full comment: pecan field trial

1400278000 14 Pine nut 0.041000 1.000 1.000 from a

Full comment: from apples

1400282000 14 Pistachio 0.031000 1.000 1.000 almond

Full comment: almond field trial

1400391000 14 Walnut 0.031000 1.000 1.000 almond

Full comment: almond field trial

1500025000 15 Barley, pearled barley 0.710000 1.000 0.360 from w

Full comment: from wheat

1500025001 15 Barley, pearled barley

- babyfood 0.710000 1.000 0.360 from w

Full comment: from wheat

1500026000 15 Barley, flour 0.710000 1.000 0.360 from w

Full co mment: from wheat

1500026001 15 Barley, flour

- babyfood 0.710000 1.000 0.360 from w

Full comment: from wheat

1500027000 15 Barley, bran 0.710000 2.300 0.360 wheat

Full comment: wheat and rice bran factor

1500065000 15 Buckwheat 0.710000 1.000 1.000 from w

Full comment: from wheat

1500066000 15 Buckwheat, flour 0.710000 0.600 1.000 from w

Full comment: from wheat and wheat flour

1500120000 15 Corn, field, flour 0.050000 1.000 0.190 corn f

Full comment: corn flour 1x

1500120001 15 Corn, field, flour

- babyfood 0.050000 1.000 0.190 corn f

Full comment: corn flour 1x

1500121000 15 Corn, field, meal 0.050000 1.000 0.190 corn m

Full comment: corn meal 1x

1500121001 15 Corn, field, meal

- babyfood 0.050000 1.000 0.190 corn m

Full comment: corn meal 1x

1500122000 15 Corn, field, bran 0.050000 2.300 0.190 wheat

Full comment: wheat and rice bran factor

1500123000 15 Corn, field, starch 0.050000 1.000 0.190 corn s

Full comment: corn starch 1x

1500123001 15 Corn, field, starch

- babyfood 0.050000 1.000 0.190 corn s

Full comment: corn starch 1x

1500124000 15 Corn, field, syrup 0.050000 1.500 0.190 corn s

Fu ll comment: corn starch 1x

1500124001 15 Corn, field, syrup

- babyfood 0.050000 1.500 0.190 corn s

Full comment: corn starch 1x

1500125000 15 Corn, field, oil 0.050000 1.000 0.190 corn o

Full comme nt: corn oil 1x

1500125001 15 Corn, field, oil

- babyfood 0.050000 1.000 0.190 corn o

Full comment: corn oil 1x

1500126000 15 Corn, pop 0.050000 1.000 0.190

1500127000 15 Corn, sweet 0.110000 1.000 1.000

1500127001 15 Corn, sweet

- babyfood 0.110000 1.000 1.000

1500226000 15 Millet, grain 0.710000 1.000 1.000 from w

Full comment: from wheat

1500231000 15 Oat, bran 0.710000 2.300 0.070 wheat

Full comment: wheat and rice bran factor

1500232000 15 Oat, flour 0.710000 1.000 0.070 from w

Full comment: from wheat

1500232001 15 Oat, flour

- babyfood 0.710000 1.000 0.070 from w

Full comment: from wheat

1500233000 15 Oat, groats/rolled oats 0.710000 1.000 0.070 from w

Full comment: from wheat

1500233001 15 Oat, groats/rolled oats

- babyfood 0.710000 1.000 0.070 from w

Full comment: from wheat

1500323000 15 Rice, white 1.050000 0.100 1.000

1500323001 15 Rice, white

- babyfood 1.050000 0.100 1.000

1500324000 15 Rice, brown 1.050000 1.000 1.000

1500324001 15 Rice, brown

- babyfood 1.050000 1.000 1.000

### Page 20 of 30

1500325000 15 Rice, flour 1.050000 0.100 1.000

1500325001 15 Rice, f lour

- babyfood 1.050000 0.100 1.000

1500326000 15 Rice, bran 1.050000 2.300 1.000

1500326001 15 Rice, bran

- babyfood 1.050000 2.300 1.000 from w

Full comment: from wheat

15003 28000 15 Rye, grain 0.710000 1.000 1.000 from w

Full comment: from wheat

1500329000 15 Rye, flour 0.710000 1.000 1.000 from w

Full comment: from wheat

1500344000 15 Sorgh um, grain 1.000000 1.000 0.150 from c

Full comment: from corn

1500345000 15 Sorghum, syrup 1.000000 1.000 1.000 from c

Full comment: from corn

1500381000 15 Triticale, flour 0.710000 0.600 1.000 from w

Full comment: from wheat and wheat flour

1500381001 15 Triticale, flour

- babyfood 0.710000 0.600 1.000 from w

Full comment: from wheat and wheat flour

1500401000 15 Wheat, grain 0.710000 1.000 0.140

1500401001 15 Wheat, grain

- babyfood 0.710000 1.000 0.140

1500402000 15 Wheat, flour 0.710000 0.600 0.140

150040200 1 15 Wheat, flour

- babyfood 0.710000 0.600 0.140

1500403000 15 Wheat, germ 0.710000 2.600 0.140

1500404000 15 Wheat, bran 0.710000 2.300 0.140

1500405000 15 Wild rice 1.050000 1.000 1.000

1800002000 18 Alfalfa, seed 0.110000 1.000 1.000

1901028000 19A Basil, fresh leaves 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

19010 28001 19A Basil, fresh leaves

- babyfood 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901029000 19A Basil, dried leaves 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901029001 19A Basil, dried leaves

- babyfood 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901118000 19A Cilantro, leaves 2.140000 1.000 1.000 from m

Full comment: from mint per C hemSAC

1901118001 19A Cilantro, leaves

- babyfood 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901144000 19A Dillweed 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901184000 19A Herbs, other 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901184001 19A Herbs, other

- babyfood 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901202000 19A Lemongrass 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901220000 19A Marjoram 2.140000 1.000 1.000 f rom m

Full comment: from mint per ChemSAC

1901220001 19A Marjoram

- babyfood 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901249000 19A Parsley, dried leaves 2.140000 1.000 1. 000 from m

Full comment: from mint per ChemSAC

1901249001 19A Parsley, dried leaves

- babyfood 2.140000 1.000 1.000 from m

Full comment: from mint per ChemSAC

1901334000 19A Savory 2.140000 1.0 00 1.000 from m

Full comment: from mint per ChemSAC

1902105000 19B Cinnamon 2.140000 1.000 1.000 from m

Full comment: from mint

1902105001 19B Cinnamon

- babyfood 2.140000 1.000 1. 000 from m

Full comment: from mint

1902119000 19B Coriander, seed 2.140000 1.000 1.000 from m

Full comment: from mint

1902119001 19B Coriander, seed

- babyfood 2.140000 1.000 1.000 from m

Full comment: from mint

1902143000 19B Dill, seed 2.140000 1.000 1.000 from m

Full comment: from mint

1902274000 19B Pepper, black and white 2.140000 1.000 1.000 from m

Full comment : from mint

1902274001 19B Pepper, black and white

- babyfood 2.140000 1.000 1.000 from m

Full comment: from mint

1902354000 19B Spices, other 2.140000 1.000 1.000 from m

Full comment: from mint

1902354001 19B Spices, other

- babyfood 2.140000 1.000 1.000 from m

### Page 21 of 30 Full comment: from mint

2001163000 20A Flax seed, oil 0.034000 0.005 1.000 from s

Full comment: from soybeans +soy oil facto r

2001319000 20A Rapeseed, oil 0.034000 0.005 1.000 from s

Full comment: from soybeans +soy oil factor

2001319001 20A Rapeseed, oil

- babyfood 0.034000 0.005 1.000 from s

Full comment: from s oybeans +soy oil factor

2001336000 20A Sesame, seed 0.710000 1.000 1.000 from w

Full comment: from wheat grain

2001336001 20A Sesame, seed

- babyfood 0.710000 1.000 1.000 from w

Full commen t: from wheat grain

2001337000 20A Sesame, oil 0.710000 0.005 1.000 from w

Full comment: from wheat grain + soy oil factor

2001337001 20A Sesame, oil

- babyfood 0.710000 0.005 1.000 from w

Full comment: from wheat grain + soy oil factor

2002330000 20B Safflower, oil 0.034000 0.005 1.000 from s

Full comment: from soybeans +soy oil factor

2002330001 20B Safflower, oil

- babyfood 0.034000 0.005 1.000 from s

Full comment: from soybeans +soy oil factor

2002364000 20B Sunflower, seed 0.034000 1.000 1.000 from s

Full comment: from soybeans

2002365000 20B Sunflower, oil 0.034000 0.005 1.000 from s

Full comment: from soybeans +soy oil factor

2002365001 20B Sunflower, oil

- babyfood 0.034000 0.005 1.000 from s

Full comment: from soybeans +soy oil factor

2003114001 20C Coconut, oil

- babyfood 0.041000 0.005 1.000 from a

Full comment: from apples and soy oil factor

2003128000 20C Cottonseed, oil 0.100000 0.005 1.000 soy oi

Full comment: soy oil factor

2003128001 20C Cottonseed, oil

- babyfood 0.100000 0.005 1.000 soy oi

Full comment: soy oil factor

2100228000 21 Mushroom 0.710000 1.000 1.000 from l

Full comment: from leafy greens

3100044000 31 Beef, meat 0.006000 1.000 1.000 from d

Full comment: from dairy cattle

3100044001 31 Beef, meat

- babyfood 0.006000 1.000 1.000 from d

Full comment: from dairy cattle

3100045000 31 Beef, meat, dried 0.006000 1.920 1.000 from d

Full comment: from dairy cattle

3100046000 31 Beef, meat byproducts 0.014000 1.000 1.000 from d

Full comment: from dairy cattle

3100046001 31 Beef, meat byproducts

- babyfood 0.014000 1.000 1.000 from d

Full comment: from dairy cattle

3100047000 31 Beef, fat 0.006000 1.000 1.000 from d

Full comment: from dairy cattle

3100047001 31 Beef, fat

- babyfood 0.006000 1.000 1.000 from d

Full comment: from dairy cattle

3100048000 31 Beef, kidney 0.014000 1.000 1.000 from d

Full comment: from dairy cattle

3100049000 31 Beef, liver 0.007000 1.000 1.000 from d

Full comment: from dairy cattle

3100049001 31 Beef, liver

- babyfood 0.007000 1.000 1.000 from d

Full comment: from dairy cattle

3200169000 32 Goat, meat 0.006000 1.000 1.000 from b

Full comment: from beef cattle

3200170000 32 Goat, meat byproducts 0.006000 1.000 1.000 from b

Full comment: from beef cattle

3200171000 32 Goat, fat 0.008000 1.000 1.000 from b

Full comment: from beef cattle

3200172000 32 Goat, kidney 0.014000 1.000 1.000 from b

Full comment: from beef cattle

3200 173000 32 Goat, liver 0.007000 1.000 1.000 from b

Full comment: from beef cattle

3300189000 33 Horse, meat 0.006000 1.000 1.000 from b

Full comment: from beef cattle

34002900 00 34 Pork, meat 0.004800 1.000 1.000

3400290001 34 Pork, meat

- babyfood 0.004800 1.000 1.000

3400291000 34 Pork, skin 0.010000 1.000 1.000

3400292000 34 Pork, meat byprod ucts 0.010000 1.000 1.000

3400292001 34 Pork, meat byproducts

- babyfood 0.010000 1.000 1.000

3400293000 34 Pork, fat 0.004800 1.000 1.000

3400293001 34 Pork, fat

- babyfood 0.00480 0 1.000 1.000

### Page 22 of 30

3400294000 34 Pork, kidney 0.010000 1.000 1.000

3400295000 34 Pork, liver 0.005000 1.000 1.000

3500339000 35 Sheep, meat 0.006000 1.000 1.000 from b

Full comment: from beef cattle

3500339001 35 Sheep, meat

- babyfood 0.006000 1.000 1.000 from b

Full comment: from beef cattle

3500340000 35 Sheep, meat byproducts 0.014000 1.000 1.000 from b

Full comment: from beef cattle

3500341000 35 Sheep, fat 0.008000 1.000 1.000 from b

Full comment: from beef cattle

3500341001 35 Sheep, fat

- babyfood 0.008000 1.000 1.000 from b

Full comment: from beef cattle

3500342000 35 Sheep, kidney 0.014000 1.000 1.000 from b

Full comment: from beef cattle

3500343000 35 Sheep, liver 0.007000 1.000 1.000 from b

Full comment: from beef cattle

3600222000 36 Milk, fat 0.003000 1.000 1.000

3600222001 36 Milk, fat

- baby food/infant formu 0.003000 1.000 1.000

3600223000 36 Milk, nonfat solids 0.003000 1.000 1.000

3600223001 36 Milk, nonfat solids

- baby food/in 0.003000 1.000 1.000

3600224000 36 Milk, water 0.003000 1.000 1.000

3600224001 36 Milk, water

- babyfood/infant form 0.003000 1.000 1.000

3600225 001 36 Milk, sugar (lactose)

- baby food/ 0.003000 1.000 1.000

3800221000 38 Meat, game 0.006000 1.000 1.000 from b

Full comment: from beef cattle

3900312000 39 Rabbit, meat 0.006000 1.000 1.000 from b

Full comment: from beef cattle

4000093000 40 Chicken, meat 0.018000 1.000 1.000

4000093001 40 Chicken, meat

- babyfood 0.018000 1.000 1.000

4000094000 40 Chicken, liver 0.018000 1.000 1.000

4000095000 40 Chicken, meat byproducts 0.018000 1.000 1.000

4000095001 40 Chicken, meat byproducts

- babyfoo 0.018000 1.000 1.000

4000096000 40 Chicken, fat 0.022000 1.000 1.000

4000096001 40 Chicken, fat

- babyfood 0.022000 1.000 1.000

4000097000 40 Chicken, skin 0.018000 1.000 1.000

4000097001 40 Chicken, skin

- babyfood 0.018000 1.000 1.000

500038200 0 50 Turkey, meat 0.018000 1.000 1.000

5000382001 50 Turkey, meat

- babyfood 0.018000 1.000 1.000

5000383000 50 Turkey, liver 0.018000 1.000 1.000

5000383001 50 Turkey, liver

- baby food 0.018000 1.000 1.000

5000384000 50 Turkey, meat byproducts 0.018000 1.000 1.000

5000384001 50 Turkey, meat byproducts

- babyfood 0.018000 1.000 1.000

5000385000 50 Turkey, fat 0.022000 1.000 1.000

5000385001 50 Turkey, fat

- babyfood 0.022000 1.000 1.000

5000386000 50 Turkey, skin 0.018000 1.000 1.000

5000386001 50 Turkey, s kin

- babyfood 0.018000 1.000 1.000

6000301000 60 Poultry, other, meat 0.018000 1.000 1.000

6000302000 60 Poultry, other, liver 0.018000 1.000 1.000

6000303000 60 Poultry, other, meat byproducts 0.018000 1.000 1.000

6000304000 60 Poultry, other, fat 0.022000 1.000 1.000

6000305000 60 Poultry, other, skin 0.018000 1.000 1.000

7000145000 70 Egg, whole 0.018000 1.000 1.000

7000145001 70 Egg, whole

- babyfood 0.018000 1.000 1.000

7000146000 70 Egg, white 0.018000 1.000 1.000

7000146001 70 Egg, white (solids)

- babyfood 0.018000 1.000 1.000

7000147000 70 Egg, yo lk 0.018000 1.000 1.000

7000147001 70 Egg, yolk

- babyfood 0.018000 1.000 1.000

8000157000 80 Fish

- freshwater finfish 0.100000 1.000 1.000

8000158000 80 Fish

- freshwater finfish, farm ra 0.100000 1.000 1.000

8000161000 80 Fish

- shellfish, crustacean 1.000000 1.000 1.000

8000162000 80 Fish

- shellfish, mollusc 4.000000 1.000 1.000

8601000000 86A Water, direct, all sources 0.031000 1.000 1.00 0

8602000000 86B Water, indirect, all sources 0.031000 1.000 1.000

9500001000 O Acerola 0.041000 1.000 1.000 from a

Full comment: from apples

9500006000 O Amaranth, grain 0.7 10000 1.000 1.000 from w

Full comment: from wheat grain

9500016000 O Artichoke, globe 0.710000 1.000 1.000 from l

Full comment: from leafy greens

9500019000 O Asparagus 0.3200 00 1.000 1.000 from h

Full comment: from head lettuce

9500020000 O Avocado 0.041000 1.000 1.000 from a

### Page 23 of 30 Full comment: from apples

9500022000 O Bamboo, shoots 2.200000 1.000 1.000 from g

Full comment: from grass

9500023000 O Banana 0.041000 1.000 1.000 from a

Full comment: from apples

9500023001 O Banana

- babyfood 0.041000 1.000 1.000 f rom a

Full comment: from apples

9500024000 O Banana, dried 0.041000 3.900 1.000 from a

Full comment: from apples

9500024001 O Banana, dried

- babyfood 0.041000 3.900 1.000 from a

Full comment: from apples

9500054000 O Belgium endive 0.320000 1.000 1.000 from h

Full comment: from head lettuce

9500060000 O Breadfruit 0.041000 1.000 1.000 from a

Full comment: from apples

9500073000 O Cactus 0.710000 1.000 1.000 from l

Full comment: from leafy greens

9500074000 O Canistel 0.041000 1.000 1.000 from a

Full comment : from apples

9500077000 O Carob 0.041000 1.000 1.000 from a

Full comment: from apples

9500089000 O Cherimoya 0.041000 1.000 1.000 from a

Full comment: from apples

9500109000 O Cocoa bean, chocolate 0.041000 1.000 1.000 from a

Full comment: from apples

9500110000 O Cocoa bean, powder 0.041000 1.000 1.000 from a

Full comment: from apples

9500111000 O Coconut, meat 0.041000 1.000 1.000 from a

Full comment: from apples

9500111001 O Coconut, meat

- babyfood 0.041000 1.000 1.000 from a

Full comment: from apples

9500112000 O Coconut, dried 0.041000 2.100 1.000 from a

Full comment: from apples

9500113000 O Coconut, milk 0.041000 1.000 1.000 from a

Full comment: from apples

9500114000 O Coconut, oil 0.041000 0.005 1.000 from a

Full comment: from apples and soy oil factor

9500115000 O Coffee, roasted bean 0.041000 1.000 1.000 from a

Full comment: from apples

950011600 0 O Coffee, instant 0.041000 1.000 1.000 from a

Full comment: from apples

9500141000 O Date 0.041000 1.000 1.000 from a

Full comment: from apples

9500151000 O Feijoa 0.041000 1.000 1.000 from a

Full comment: from apples

9500153000 O Fig 0.041000 1.000 1.000 from a

Full comment: from apples

9500154000 O Fig, dried 0.041000 1.000 1.000 from a

Full comment: from apples

9500177000 O Grape, leaves 0.520000 1.000 0.990

9500178000 O Grape, raisin 0.520000 4.400 0.940

9500183000 O Gu ava 0.041000 1.000 1.000 from a

Full comment: from apples

9500183001 O Guava

- babyfood 0.041000 1.000 1.000 from a

Full comment: from apples

9500186000 O Honey 0.003000 1.000 1.000 from m

Full comment: from milk

9500186001 O Honey

- babyfood 0.003000 1.000 1.000 from m

Full comment: from milk

9500188000 O Hop 0.100000 1.000 1.000

9500193000 O Jackfruit 0.041000 1.000 1.000 from a

Full comment: from apples

9500209000 O Longan 0.04100 0 1.000 1.000 from a

Full comment: from apples

9500211000 O Lychee 0.041000 1.000 1.000 from a

Full comment: from apples

9500212000 O Lychee, dried 0.041000 1.850 1.0 00 from a

Full comment: from apples

9500214000 O Mamey apple 0.041000 1.000 1.000 from a

Full comment: from apples

9500215000 O Mango 0.041000 1.000 1.000 from a

Full comment: from apples

### Page 24 of 30

9500215001 O Mango

- babyfood 0.041000 1.000 1.000 from a

Full comment: from apples

9500216000 O Mango, dried 0.041000 1.000 1.000 from a

Full comment: from apples

9500217000 O Mango, juice 0.041000 1.000 1.000 from a

Full comment: from apples

9500217001 O Mango, juice

- babyfood 0.041000 1.000 1.000 from a

Full comment: from apples

9500218000 O Maple, sugar 0.041000 1.000 1.000 from a

Full comment: from apples

9500219000 O Maple syrup 0.041000 1.000 1.000 from a

Full comment: from apples

9500235 000 O Olive 0.041000 1.000 1.000 from a

Full comment: from apples

9500236000 O Olive, oil 0.041000 0.005 1.000 from a

Full comment: from apples +soy oil factor

9500243000 O Palm heart, leaves 2.200000 1.000 1.000 from g

Full comment: from grass

9500244000 O Palm, oil 2.200000 0.005 1.000 from g

Full comment: from grass + soy oil factor

9500244001 O Palm, oil

- babyfood 2.200000 0.005 1.000 from g

Full comment: from grass + soy oil factor

9500245000 O Papaya 0.041000 1.000 1.000 from a

Full comment: from appl es

9500245001 O Papaya

- babyfood 0.041000 1.000 1.000 from a

Full comment: from apples

9500246000 O Papaya, dried 0.041000 1.800 1.000 from a

Full comment: from apples

9500247000 O Papaya, juice 0.041000 1.500 1.000 from a

Full comment: from apples

9500252000 O Passionfruit 0.041000 1.000 1.000 from a

Full comment: from apples

9500252001 O Passionfr uit

- babyfood 0.041000 1.000 1.000 from a

Full comment: from apples

9500253000 O Passionfruit, juice 0.041000 1.000 1.000 from a

Full comment: from apples

9500253001 O Passionfruit, juice

- bab yfood 0.041000 1.000 1.000 from a

Full comment: from apples

9500254000 O Pawpaw 0.041000 1.000 1.000 from a

Full comment: from apples

9500263000 O Peanut 0. 080000 1.000 0.420 from p

Full comment: from potato

9500264000 O Peanut, butter 0.080000 1.890 0.420 from p

Full comment: from potato

9500265000 O Peanut, oil 0.080000 0.005 0.420 from p

Full comment: from potato + soy oil factor

9500275000 O Peppermint 2.140000 1.000 1.000

9500276000 O Peppermint, oil 2.140000 0.001 1.000

9500277000 O Persimmon 0.041000 1.000 1.000 from a

Full comment: from apples

9500279000 O Pineapple 0.500000 1.000 1.000 from c

Full comment: from cucurbits

9500279001 O Pineapple

- babyfood 0.500000 1.000 1.000 from c

Full comment: from cucurbits

9500280000 O Pineapple, dried 0.500000 5.000 1.000 from c

Full comment: from cucurbits

9500281000 O Pineapple, juice 0.500000 1.700 1.000 from c

Full comment: from cucurbits

9500281001 O Pineapple, juice

- babyfood 0.500000 1.700 1.000 from c

Full comment: from cucurbits

9500283000 O Plantain 0.04100 0 1.000 1.000 from a

Full comment: from apples

9500284000 O Plantain, dried 0.041000 3.900 1.000 from a

Full comment: from apples

9500289000 O Pomegranate 0.041000 1.000 1.0 00 from a

Full comment: from apples

9500306000 O Psyllium, seed 0.710000 1.000 1.000 from w

Full comment: from wheat grain

9500311000 O Quinoa, grain 0.710000 1.000 1.000 from w

Full comment: from wheat grain

9500333000 O Sapote, Mamey 0.041000 1.000 1.000 from a

Full comment: from apples

### Page 25 of 30

9500346000 O Soursop 0.041000 1.000 1.000 from a

Full comment: from apples

9500351000 O Spanish lime 0.041000 1.000 1.000 from a

Full comment: from apples

9500352000 O Spearmint 2.140000 1.000 1.000

9500353000 O Spea rmint, oil 2.140000 0.001 1.000

9500358000 O Starfruit 0.041000 1.000 1.000 from a

Full comment: from apples

9500361000 O Sugar apple 0.041000 1.000 1.000 fr om a

Full comment: from apples

9500363000 O Sugarcane, molasses 2.200000 2.400 0.540 grass

Full comment: grass + sugar beet molasses factor

9500363001 O Sugarcane, molasses

- babyfood 2.200000 2.400 0.540 grass

Full comment: grass + sugar beet molasses factor

9500368000 O Tamarind 0.041000 1.000 1.000 from p

Full comment: from peaches (high tree fruit)

9500372000 O Tea, dried 0.330000 1.000 1.000 from c

Full comment: from cane berries

9500373000 O Tea, instant 0.330000 1.000 1.000 from c

Full comment: from cane berries

9500390000 O Vinegar 0.025000 1.000 1.000 from a

Full comment: from apples

9500397000 O Water chestnut 5.000000 1.000 1.000 from w

Full comment: from water

9500398000 O Watercress 5.00000 0 1.000 1.000 from w

Full comment: from water

### Page 26 of 30



## Attachment 2. Chronic Food Plus Water Output File

C ompany Name Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for ENDOTHALL NHANES 2003

- 2008 2

- day

Residue file name: C: \ Documents and Settings \ stadayon \ My Documents \ Work in

Progress \ Endothall \ ENDOTHALL12DEC2012.R08

Adjustment factor #2 used.

Analysis Date 12

- 12

- 2012/07:11: 26 Residue file dated: 12

- 12

- 2012/06:41:12

Reference dose (RfD, Chronic) = .007 mg/kg bw/day

===============================================================================

Total exposure by population subgroup

--------------------- ----------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of

Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.002229 31.8%

Hi spanic 0.002138 30.5%

Non

- Hisp

- White 0.002250 32.1%

Non

- Hisp

- Black 0.002002 28.6%

Non

- Hisp

- Other 0.002718 38.8%

Nursing Infants 0.002324 33.2%

Non

- Nursing Infants 0.005316 75.9%

Female 13+ PREG 0.002002 28 .6%

Children 1

- 6 0.005049 72.1%

Children 7

- 12 0.002351 33.6%

Male 13

- 19 0.001448 20.7%

Female 13

- 19/NP 0.001521 21.7%

Male 20+ 0.001902 27.2%

Female 20+/NP 0.001997 28.5%

Seniors 55+ 0.001976 28.2%

All Infants 0.004392 62.7%

Female 13

- 50 0.001871 26.7%

Children 1

- 2 0.006314 90.2%

Children 3

- 5 0.004575 65.4%

Children 6

- 12 0.002554 36.5%

Youth 13

- 19 0.001483 21.2%

Adults 20

- 49 0.001932 27.6%

Adults 50

- 99 0.001983 28.3%

Female 13

- 49 0.001874 26.8%

### Page 27 of 30



## Attachment 3 . Percent Crop Treated memo from BEAD

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON D.C., 20460



# NOV 19 

# 2012

OFFICE OF PREVENTION, PESTICIDES AND

TOXIC SUBSTANCES



## MEMORANDUM

SUBJECT: Updated Estimates of Percent Commodity Exposed to Endothall via Irrigation

(DP# 369862, 369863)

FROM: Derek Berwald, Ph.D., Economist 

# \ M.

. \

Economic Analysis Branch 

# '

-- ..J

1

Bill Phillips, II, Ph.D., Agronomist

Biological Analysis Branch

Biological and Economic Analysis

THRU:

TO: Seyed Tadayon, Chemist Ris k

Assessment Branch V Healt h

Effects Division (7509P)

Product Review Panel: October 23, 2012

This document provides estimates of the percent of various commodities that could be exposed t o

endothall via irrigation water. It 

## updates previous estimates for the percentage of crops that ma y

be exposed to endothall which EPA is reasonably certain will not be exceeded (Phillips and

Berwald, 2009 [attached]). Crops will be exposed to endothall by irrigation water, so the

maximum percent that could be exposed is the maximum share of production from irrigated land,

which is estimated here. This information is needed for a dietary risk assessment.

### Page 28 of 30



## Estimates, shown 

## in Table 1, are derived using two methods. Where data on irrigated and

dr y land production are available, the estimates are based on the share of production from

irrigated land, which is the maximum percent of the crop that could be exposed to endothall.

These data were reported in the 2007 Census of Agriculture (USDA 2009). The estimates

provided will be an upper bound on the percentage of crops that may have been irrigated with

water from canals that were treated with endothall, because some of the irrigated crops are not

grown 

## in areas where endothall will be used. For these crops (barley, com, dry edible beans,

peanuts, oats, rice, sorghum, soybeans, sugarbeets, sugarcane, and wheat), the estimates are

unchanged from the earlier memo because more recent irrigation data are unavailable. The

irrigation data for 2011 should be available soon; however the release date is unknown.

Other crops that are important to the dietary risk assessment do not have data on irrigated and non

irrigated production available. The figures provided in T able 1 are the share of production from

2011 grown in 1 7 western states where irrigation is used extensively and endothall use will be

concentrated. These are states where substantial amounts of water are transported through open

canal systems to be used for irrigation. 

## It is these systems where weed control is important, and

endothall is likely to be used. Estimates based on share of total production 

## in the 17 western states

are provided for apples, grapes, oats, green peas, wheat, watermelon, and strawberries. Except for

green peas, where the earlier estimate was 

## in error, these maximum estimates have

not changed much. The largest changes were in apples, where the maximum estimate of treated

crops used for juice or cider fell by 9 percentage points, while the estimate of apples for

. processing fell by 7 points. Watermelon, where the maximum estimate fell by 6 percentage

points, was another relatively large change. The most important change from the earlier memo

was green peas, where the current estimate is up to 43% of the crop that could potentially be

treated. This is substantially higher than the prior estimate of 11 percent, which was a

calculation error.

### Page 29 of 30 

## Estimated

Percent Crop

Share of Share of Treated for

Irrigated

Production Production

in 

## West 1 

## Dietary Risk

Assessment

Apple n/a 

# 62 62

Fresh market n/a 

# 76 76

Processing n/a 

# 37 37

Juice and n/a 

# 40 40

Cider

Canned n/a 

# 14 14

Barley for grain 

# 36 36

Com for grain 

# 19 19

Dry Bean s 2 

# 32 32

Grape n/a 

# 95 95

Fresh market n/a 

# 99 99

Processing n/a 

# 94 94

Green Peas n/a 

# 4 3 2 

# 43

Oats for grain 

# 7 37 7

Peanut for nuts 

# 42 42

Rice 

# 100 100

Sorghum for grain 

# 15 15

Soybean for beans

· 

# 9 9

Strawberry n/a 

# 90 90

Fresh market n/a 

# 88 88

Processing n/a 

# 100 100

Sugarbeet for sugar 

# 37 37

Sugarcane for sugar 

# 54 54

Watermelon n/a 

# 33 33

Wheat for grain 

# 14 73 14

Source: USDA 2012a, 2012b, 2012c, 2009, EPA calculations.

1. 

### Based on share of2011 total production in Arizona, California, Colorado,

Idaho, Kansas, Montana, Nebraska, Nevada, New Mexico, North Dakota,

Oklahom a

, Oregon, South Dakota, Texas, Utah, Washington, and Wyoming.

Estimates are only provided for certain crops.

2. Note: largest change from 2008 to 2011, due to error in data entry 

### in earlier

table

### Page 30 of 30 

## References



## USDA 2012a. US Department of Agriculture, National Agricultural Statistics Service, Vegetables

2011 Summary. January 2012. Available here:

http://usda01.library.comell.edu/usdalcurrent/VegeSumm/VegeSumm

- 01

- 26

- 2012.txt

USDA 2012b. US Department of Agriculture, National Agricultural Statistics Service , Noncitrus Fruits

and Nuts 2011 Summar y

. July 2012. Available here:

http://usda01.library.comell.edu/usdalcurrent/NoncFruiNu/NoncFruiNu

- 07

- 06

- 2012.txt

USDA 2012c. US Department of Agriculture, National Agricultural Statistics Service, Crop Production

2011 Summary. January 2012. Available here:

http://usda01.library.cornell.edu/usda/current/CropProdSu/CropProdSu

- 01

- 12

- 2012.txt

USDA 200 9

. US Department of Agriculture, 2007 Census of Agriculture United States Summary and

State Data Volume 1, Geographic Area Series, Part 51. February 2009, updated September 200 9

. Available here: http://www.agcensus.usda.gov/Publications/2007/Full Report/Volume 1,



## Chapter 2 U S State Level/st99 2 032 032.pdf

US EPA, 2009. Phillips, Bill II, and Derek Berwald, BEAD Memo: Estimates of Crop Irrigation for

Endothall Registration (DP# 369862, 369863), 

## October 7, 2009. ( See Attached )