EX-10.5



 Exhibit 10.5 

Trevi Therapeutics, Inc. 
 STOCK
OPTION AGREEMENT 
 Trevi Therapeutics, Inc. (the “Company”) hereby grants the following stock option pursuant
to its 2019 Stock Incentive Plan. The terms and conditions attached hereto are also a part hereof. 
 Notice of Grant 

 

			
	Name of optionee (the “Participant”):	 	 
	Grant Date:	 	 
	Incentive Stock Option or Nonstatutory Stock Option:	 	 
	Number of shares of the Company’s Common Stock subject to this option (“Shares”):	 	 
	Option exercise price per Share:1	 	 
	Number, if any, of Shares that vest immediately on the grant date:	 	 
	Shares that are subject to vesting schedule:	 	 
	Vesting Start Date:	 	 
	Final Exercise Date: 2	 	 

 Vesting Schedule: 
  

			
	Vesting Date:	 	Number of Options that Vest:
	  	 	  
	  	 	  
	
All vesting is dependent on the Participant remaining an Eligible Participant, as provided herein.


 This option satisfies in full all commitments that the Company has to the Participant with respect to the
issuance of stock, stock options or other equity securities. 
  

			
		  	Trevi Therapeutics, Inc.
	
                   
                                         

	  	
	 Signature of Participant
	  	
	
                   
                                         

	  	By:                                     
                   
	 Street Address
	  	      Name of Officer
	
                   
                                         

	  	      Title:
	 City/State/Zip Code
	  	

  

                          
                               

1             This must be at least 100% of
the Grant Date Fair Market Value (as defined in the Plan) of the Common Stock on the date of grant (110% in the case of a Participant that owns more than 10% of the total combined voting power of all classes of stock of the Company or its parent or
subsidiary (a “10% Shareholder”)) for the option to qualify as an incentive stock option (an “ISO”) under Section 422 of the Code. 

2             The Final Exercise Date must be
no more than 10 years (5 years in the case of a 10% Shareholder) from the date of grant for the option to qualify as an ISO. The correct approach to calculate the final exercise date is to use the day immediately prior to the date ten years out from
the date of the stock option award grant (5 years in the case of a 10% stockholder). 







 Trevi Therapeutics, Inc. 

Stock Option Agreement 

Incorporated Terms and Conditions 

1.            Grant of Option. 

This agreement evidences the grant by the Company, on the grant date (the “Grant Date”) set forth in the Notice
of Grant that forms part of this agreement (the “Notice of Grant”), to the Participant of an option to purchase, in whole or in part, on the terms provided herein and in the Company’s 2019 Stock Incentive Plan (the
“Plan”), the number of Shares set forth in the Notice of Grant of common stock, $0.001 par value per share, of the Company (“Common Stock”), at the exercise price per Share set forth in
the Notice of Grant. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on the Final Exercise Date set forth in the Notice of Grant (the “Final Exercise Date”). 

The option evidenced by this agreement shall be intended to be an incentive stock option as defined in Section 422 of the Internal
Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the “Code”) to the maximum extent permitted by law, solely to the extent designated as an incentive stock option in the Notice of Grant. Except as
otherwise indicated by the context, the term “Participant”, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms. 

2.            Vesting Schedule. 

This option will become exercisable (“vest”) in accordance with the vesting schedule set forth in the Notice of Grant.

 The right of exercise shall be cumulative so that to the extent the option is not exercised in any period to the maximum extent
permissible it shall continue to be exercisable, in whole or in part, with respect to all Shares for which it is vested until the earlier of the Final Exercise Date or the termination of this option under Section 3 hereof or the Plan. 

3.            Exercise of Option. 

(a)        Form of Exercise. Each election to exercise this option shall be in writing, in the
form of the Stock Option Exercise Notice attached as Annex A, signed by the Participant, and received by the Company at its principal office, accompanied by this agreement, or in such other form (which may be electronic) as is approved by the
Company, together with payment in full in the manner provided in the Plan. The Participant may purchase less than the number of shares covered hereby, provided that no partial exercise of this option may be for any fractional share. 

(b)        Continuous Relationship with the Company Required. Except as otherwise provided in
this Section 3, this option may not be exercised unless the Participant, at the time he or she exercises this option, is, and has been at all times since the Grant Date, an employee, director or officer of, or consultant or advisor to, the
Company or any other entity the employees, officers, directors, consultants, or advisors of which are eligible to receive option grants under the Plan (an “Eligible Participant”). 

  
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 (c)      Termination of Relationship with the Company. If
the Participant ceases to be an Eligible Participant for any reason, then, except as provided in paragraphs (d) and (e) below, the right to exercise this option shall terminate three months after such cessation (but in no event
after the Final Exercise Date), provided that this option shall be exercisable only to the extent that the Participant was entitled to exercise this option on the date of such cessation. Notwithstanding the foregoing, if the
Participant, prior to the Final Exercise Date, violates the restrictive covenants (including, without limitation, the non-competition, non-solicitation, or
confidentiality provisions) of any employment contract, any non-competition, non-solicitation, confidentiality or assignment agreement to which the Participant is a
party, if any, or any other agreement between the Participant and the Company, the right to exercise this option shall terminate immediately upon such violation. 

(d)      Exercise Period Upon Death or Disability. If the Participant dies or becomes disabled (within
the meaning of Section 22(e)(3) of the Code) prior to the Final Exercise Date while he or she is an Eligible Participant and the Company has not terminated such relationship for “cause” as specified in paragraph (e) below, this
option shall be exercisable, within the period of one year following the date of death or disability of the Participant, by the Participant (or in the case of death by an authorized transferee), provided that this option shall be
exercisable only to the extent that this option was exercisable by the Participant on the date of his or her death or disability, and further provided that this option shall not be exercisable after the Final Exercise Date. 

(e)      Termination for Cause. If, prior to the Final Exercise Date, the Participant’s employment
is terminated by the Company for Cause (as defined in below), the right to exercise this option shall terminate immediately upon the effective date of such termination of employment. If, prior to the Final Exercise Date, the Participant is given
notice by the Company of the termination of his or her employment by the Company for Cause, and the effective date of such employment termination is subsequent to the date of delivery of such notice, the right to exercise this option shall be
suspended from the time of the delivery of such notice until the earlier of (i) such time as it is determined or otherwise agreed that the Participant’s employment shall not be terminated for Cause as provided in such notice or
(ii) the effective date of such termination of employment (in which case the right to exercise this option shall, pursuant to the preceding sentence, terminate upon the effective date of such termination of employment). If the Participant is
subject to an individual employment agreement with the Company or eligible to participate in a Company severance plan or arrangement, in any case which agreement, plan or arrangement contains a definition of “cause” for termination of
employment, “Cause” shall have the meaning ascribed to such term in such agreement, plan or arrangement. Otherwise, “Cause” shall mean willful misconduct by the Participant or willful failure by the
Participant to perform his or her responsibilities to the Company (including, without limitation, breach by the Participant of any provision of any employment, consulting, advisory, nondisclosure,
non-competition or other similar agreement between the Participant and the Company), as determined by the Company, which determination shall be conclusive. The Participant’s employment shall be considered
to have been terminated for Cause if the Company determines, within 30 days after the Participant’s resignation, that termination for Cause was warranted. 

  
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 4.            Tax Matters. 

(a)      Withholding. No Shares will be issued pursuant to the exercise of this option unless and until
the Participant pays to the Company, or makes provision satisfactory to the Company for payment of, any federal, state or local withholding taxes required by law to be withheld in respect of this option. 

(b)      Disqualifying Disposition. If this option is an incentive stock option and the Participant
disposes of Shares acquired upon exercise of this option within two years from the Grant Date or one year after such Shares were acquired pursuant to exercise of this option, the Participant shall notify the Company in writing of such disposition.

 5.            Transfer Restrictions; Clawback. 

(a)      This option may not be sold, assigned, transferred, pledged or otherwise encumbered by the Participant,
either voluntarily or by operation of law, except by will or the laws of descent and distribution, and, during the lifetime of the Participant, this option shall be exercisable only by the Participant. 

(b)      In accepting this option, the Participant agrees to be bound by any clawback policy that the Company
has in place or may adopt in the future. 
 6.            Provisions of the Plan. 

This option is subject to the provisions of the Plan (including the provisions relating to amendments to the Plan), a copy of which is
furnished to the Participant with this option. 

  
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 ANNEX A 

Trevi Therapeutics, Inc. 

Stock Option Exercise Notice 
 Trevi
Therapeutics, Inc. 
 195 Church Street, 14th Floor 

New Haven, CT 06510 
 Dear Sir or Madam: 

I,                      (the
“Participant”), hereby irrevocably exercise the right to purchase                  shares of the Common Stock, $0.001 par value per share
(the “Shares”), of Trevi Therapeutics, Inc. (the “Company”) at $         per share pursuant to the Company’s 2019 Stock
Incentive Plan and a stock option agreement with the Company dated              (the “Option Agreement”). Enclosed herewith is a payment of
$        , the aggregate purchase price for the Shares. The certificate for the Shares should be registered in my name as it appears below or, if so indicated below, jointly in my name and the name of
the person designated below, with right of survivorship. 
  

	
	Dated:
                                         
            
	
	                                      
                          
	Signature
	Print Name:
	
	Address:
	
	                                      
                          
	                                      
                          

 Name and address of persons in whose name the Shares are to be jointly registered (if applicable): 

 

                          
                                         
       

  
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