EX-4.1



 Exhibit 4.1 
  





 
 ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# COMMON STOCK COMMON STOCK PAR VALUE $0.001 Certificate Shares Number
* * 000000 ****************** * * * 000000 ***************** ZQ00000000 **** 000000 **************** TREVI THERAPEUTICS, INC. ***** 000000 *************** ****** 000000 ************** INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE ** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample SEE REVERSE FOR CERTAIN DEFINITIONS **** Mr. Alexander David Sample **** Mr. Alexander David
Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David THIS CERTIFIES THAT Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David
Sample **** Mr. Alexander David Sample **** Mr. MR. Alexander David SAMPLE Sample **** Mr. Alexander David & Sample MRS. **** Mr. Alexander SAMPLE David Sample **** Mr. Alexander & David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr Alexander David Sample **** Mr. Alexander David Sample **** CUSIP 89532M 10 1 Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander MR. David
Sample SAMPLE **** Mr. Alexander David Sample **** &Mr. Alexander MRS. David Sample SAMPLE **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David
Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander
David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Sample **** Mr. Sample is the owner of **000000**Shares****000000** Shares**** 000000** Shares**** 000000** Shares**** 000000**Shares****
000000**Shares****000000**Shares****000000**Shares*** *000000** Shares**** 000000 ** Shares **** 000000 **Shares****000000**Shares**** 000000** Shares****000000 ** Shares****000000** Shares **** 000000** Shares**** 000000** Shares****000000**
Shares**** 000000** Shares****000000** Shares**** 000000** Shares****000000** Shares****000000** Shares****000000** Shares****0 THIS CERTIFICATE IS TRANSFERABLE IN 00000** Shares****000000** Shares****000000** Shares****000000** Shares****000000**
Shares****000000** Shares****000000** Shares****000000** Shares****00 ***ZERO HUNDRED THOUSAND 0000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000
CITIES DESIGNATED BY THE TRANSFER 000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****0000 AGENT, AVAILABLE ONLINE AT 00** Shares****000000**
Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****00000 0** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000**
Shares****000000** Shares****000000 ZERO HUNDRED AND ZERO*** www.computershare.com ** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000* *
Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000** Shares****000000**
Shares****000000** Shares****000000** Shares****000000**S FULLY-PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK OF Trevi Therapeutics, Inc. (hereinafter called the “Company”), transferable on the books of the Company in person or by duly
authorized attorney, upon surrender of this Certificate properly endorsed. This Certificate and the Shares represented hereby, are issued and shall be held subject to all of the provisions of the Certificate of Incorporation, as amended, and the
By-Laws, as amended, of the Company (copies of which are on file with the Company and with the Transfer Agent), to all of which each holder, by acceptance hereof, assents. This Certificate is not valid unless countersigned and registered by the
Transfer Agent and Registrar. Witness the facsimile seal of the Company and the facsimile signatures of its duly authorized officers. DATED DD-MMM-YYYY RAPEU E T COUNTERSIGNED AND REGISTERED: H I T POR C R A COMPUTERSHARE TRUST COMPANY, N.A. V I CO
TE S, I Chief Executive Officer R E N TRANSFER AGENT AND REGISTRAR, T C . 3/17/11 DEL RE AWA By Chief Financial Officer AUTHORIZED SIGNATURE PO BOX 43004, Providence, RI 02940-3004 MR A SAMPLE DESIGNATION (IF ANY) ADD 1 ADD 2 ADD 3 ADD 4
CUSIP/IDENTIFIER XXXXXX XX X Holder ID XXXXXXXXXX Insurance Value 00.1,000,000 Number of Shares 123456 DTC 12345678901234512345678 Certificate Numbers Num/No Denom. Total. 1234567890/1234567890 111 1234567890/1234567890 222 1234567890/1234567890 333
1234567890/1234567890 444 1234567890/1234567890 555 1234567890/1234567890 666 Total Transaction 7 







  

TREVI THERAPEUTICS, INC. 
 THE COMPANY WILL FURNISH
WITHOUT CHARGE TO EACH SHAREHOLDER WHO SO REQUESTS, A SUMMARY OF THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE, PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OF THE COMPANY AND THE QUALIFICATIONS, LIMITATIONS OR
RESTRICTIONS OF SUCH PREFERENCES AND RIGHTS, AND THE VARIATIONS IN RIGHTS, PREFERENCES AND LIMITATIONS DETERMINED FOR EACH SERIES, WHICH ARE FIXED BY THE CERTIFICATE OF INCORPORATION OF THE COMPANY, AS AMENDED, AND THE RESOLUTIONS OF THE BOARD OF
DIRECTORS OF THE COMPANY, AND THE AUTHORITY OF THE BOARD OF DIRECTORS TO DETERMINE VARIATIONS FOR FUTURE SERIES. SUCH REQUEST MAY BE MADE TO THE OFFICE OF THE SECRETARY OF THE COMPANY OR TO THE TRANSFER AGENT. THE BOARD OF DIRECTORS MAY REQUIRE THE
OWNER OF A LOST OR DESTROYED STOCK CERTIFICATE, OR HIS LEGAL REPRESENTATIVES, TO GIVE THE COMPANY A BOND TO INDEMNIFY IT AND ITS TRANSFER AGENTS AND REGISTRARS AGAINST ANY CLAIM THAT MAY BE MADE AGAINST THEM ON ACCOUNT OF THE ALLEGED LOSS OR
DESTRUCTION OF ANY SUCH CERTIFICATE. 
  

											
	  

The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to
applicable laws or regulations:

	 			 
	 TEN COM
	 	- as tenants in common	  	 UNIF GIFT MIN ACT    -
  
	  	--------------------------------Custodian-----------------------------------
	 	 		  		  	(Cust)                 	  		 	(Minor)
	 	 		  		  		  	 
	 TEN ENT
	 	-  as tenants by the entireties	  		  	under Uniform Gifts to Minors Act -----------------------------------
	 	 		  		  		  		 	(State)
	 JT TEN
	 	 - as joint tenants with right of survivorship

  and not as tenants in common
	  	 UNIF TRF MIN ACT    -
  
	  	  

------------------------Custodian (until age-----------------------------)

	 	  		  	 (Cust)
	  		 	 
	 	 		  		  	----------------under Uniform Transfers to Minors Act-------------
	 	 		  		  	 (Minor)
	  		 	(State)              
	
Additional abbreviations may also be used though not in the above list.

 


  

			
		 	PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE
	For value received, ____________________________hereby sell, assign and transfer unto	 	 


 

	
	 (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE, OF
ASSIGNEE)

	      

	      



 

			
	    	 	    Shares
	of the Common Stock represented by the within Certificate, and do hereby irrevocably constitute and appoint	 	
	    	 	    Attorney
	to transfer the said stock on the books of the within-named Company with full power of substitution in the premises.	 	

  

									
	 Dated: _____________________________________20 _______________
	 		  	Signature(s) Guaranteed: Medallion Guarantee Stamp
		 		 		 	     
	  	 THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN
ELIGIBLE GUARANTOR INSTITUTION (Banks, Stockbrokers, Savings and Loan Associations and Credit Unions) WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE
17Ad-15.

	 Signature:
	 	  
	 	
	  
 Signature:
	 	  
  
	 	
	     
	 	 Notice:
	 	 The signature to this assignment must correspond with the name as written upon the face of the certificate, in every particular,
without alteration or enlargement, or any change whatever.
	 		  	 
		 		 		 		  	 

  

					
	 




	  	 The IRS requires that the named transfer agent (“we”) report the cost basis of certain shares or units acquired after
January 1, 2011. If your shares or units are covered by the legislation, and you requested to sell or transfer the shares or units using a specific cost basis calculation method, then we have processed as you requested. If you did not specify a
cost basis calculation method, then we have defaulted to the first in, first out (FIFO) method. Please consult your tax advisor if you need additional information about cost basis.

 
 If you do not keep in contact with the issuer or do not have any activity
in your account for the time period specified by state law, your property may become subject to state unclaimed property laws and transferred to the appropriate state.