EXHIBIT 10.18


THIS   SUPPLEMENT  NO.  3  TO  THE  SUBLICENSE   AND  SUPPLY   AGREEMENT   (this
"Supplement"),  effective as of August 5, 2002 (the "Effective Date") is entered
into  by  and  between  TRINITY  ASSETS  COMPANY  LIMITED  ("TAC"),   a  company
incorporated  in  Thailand,  and  TRINITY  MEDICAL  GROUP USA,  INC.,  a Florida
corporation ("TMGUSA"), with respect to the following facts.

     A.   TRINITY MEDICAL GROUP USA, INC.  ("TMGUSA") and TRINITY ASSETS COMPANY
          LIMITED  ("TAC")  entered  into  a  Sublicense  and  Supply  Agreement
          ("Sublicense  and Supply  Agreement")  dated August 4, 2000, and first
          amended through the SUPPLEMENT TO THE SUBLICENSE AND SUPPLY  AGREEMENT
          dated August 5, 2000, and second amended  through the SUPPLEMENT NO. 2
          TO THE  SUBLICENSE  AND SUPPLY  AGREEMENT  dated June 26,  2002,  both
          parties hereby agree to amend said  Sublicense  and Supply  Agreements
          under the terms and conditions of this agreement.

NOW, THEREFORE, the parties agree as follows:

                                    ARTICLE 1
                                  CONSIDERATION

Article 3.1 of the Supplement No. 2 To The Sublicense and Supply Agreement shall
be deleted in its entirety and restated to read as follows:

Consideration
-------------

3.1 Trinity shall provide the following to TAC as consideration for the addition
of  Article  4.4 above and for TAC  absorbing  50% of the  increase  in  Product
purchase  price  allocated  to  IRC  as  per  Amendment  No.  3 to  License  and
Collaboration Agreement by and between TMGUSA and IRC, dated June 26, 2002:

(i) TMGUSA  shall  provide to TAC two (2) million  shares of IRC stock issued by
IRC in  connection  with the  execution  of the  Amendment  No. 3 to License and
Collaboration  Agreement by and between  TMGUSA and IRC, dated June 26, 2002, as
soon as  administratively  practicable  after  receipt of the IRC stock first by
TMGUSA.


(ii) TMGUSA shall  provide to TAC one (1) million  shares issued by IRC, as soon
as administratively practicable after receipt of the IRC shares first by TMGUSA,
and only upon receipt of purchase order from TAC and when TAC  irrevocably  pays
its  purchase  price to TMGUSA for an  accumulated  amount of  300,000  doses of
REMUNE.

(iii) TMGUSA shall provide to TAC one (1) million  shares issued by IRC, as soon
as administratively practicable after receipt of the IRC shares first by TMGUSA,
and only upon receipt of purchase order from TAC and when TAC  irrevocably  pays
its  purchase  price to TMGUSA for an  accumulated  amount of  600,000  doses of
REMUNE.

(iv) TMGUSA shall  provide to TAC one (1) million  shares issued by IRC, as soon
as administratively practicable after receipt of the IRC shares first by TMGUSA,
and only upon receipt of purchase order from TAC and when TAC  irrevocably  pays
its purchase  price to TMGUSA for an  accumulated  amount of 1,000,000  doses of
REMUNE.

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IN WITNESS WHEREOF, the parties have executed this Supplement as of the date set
forth above.

For and on behalf of
TRINITY MEDICAL GROUP USA, INC.

By:

/s/ James Namnath                       /s/ Vina Churdboonchart
-----------------                       -----------------------
James Namnath, CEO                      Vina Churdboonchart, President

For and on behalf of
TRINITY ASSETS COMPANY LIMITED

By:

/s/ Inthanom Churdboonchart             /s/ Orranart Churdboonchart
---------------------------             ---------------------------
Inthanom Churdboonchart                 Orranart Churdboonchart