### United States Prevention, Pesticides EPA 738- R - 05- 008 Environmental Protection and Toxic Substances September 2005 Agency (7508C) 

# Reregistration Eligibility Decision for Endothall

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# Reregistration Eligibilit y Decision (RED) Document for Endothall List B Case Number 2245

Approved by: Date: Debra Edwards, Ph. D. Director Special Review and Reregistration Division

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### Table of Contents Endothall Reregistration Eligibility Decision Team ............................................................. i Glossary of Terms and Abbreviations ................................................................................ ii Abstract ............................................................................................................................... iv I. Introduction...................................................................................................................... 1 II. Chemical Overview ........................................................................................................ 2 A. Endothall and Salts Nomenc lature ............................................................................. 3 B . Use Sites ..................................................................................................................... 3 C . Formulations ............................................................................................................... 3 D. Methods of application ............................................................................................... 3 E

. Use rates ..................................................................................................................... 4 F. Annual usage ............................................................................................................... 4 G. Tolerances in Use Prof ile ........................................................................................... 4 H. Technical Registrant ................................................................................................... 5 III. Summary of Risk Assessment ...................................................................................... 5 A. Human Health Risk Assessment ................................................................................ 5 1. Hazard Profile ......................................................................................................... 5 2. Dietary Risk (Food) ................................................................................................ 7 a. Acute Dietary Risk (Food ................................................................................... 8 b. Chronic Dietary Risk (Food) .............................................................................. 8 3. Cancer Dietary Risk (Food) .................................................................................. 10 4. Drinking Water Dietary Risk ................................................................................ 10 a. Aquatic Uses ..................................................................................................... 10 b. Terrestrial Uses ................................................................................................. 12 5. Chronic Risk from Food Plus Drinking Water ..................................................... 12 6. Residential Risk .................................................................................................... 13 7. Aggregate Risk ...................................................................................................... 14 8. Occupational Risk ................................................................................................. 14 a. Occupational Handler Summary ....................................................................... 15 i. Terrestrial Applications ................................................................................. 15 ii. Aquatic Applications .................................................................................... 15 iii. Cooling Tower (Biocide) Applications ....................................................... 16 b. Post- application Occupational Risk .................................................................. 16 9. Human Incident Summary .................................................................................... 17 B. Ecological Risk ......................................................................................................... 17 1. Environmental Fate and Transport ........................................................................ 17 2. Terrestrial Organism Risk ..................................................................................... 18 a. Risks from Use of Endothall N, N - dimethylalkylamine Salt ............................ 18 3. Aquatic Organism Risk ......................................................................................... 19 a. Ri sks from Use of Endothall N, N - dimethylalkylamine Salt ............................ 19 b. Risks from Use of Endothall Dipotassium Salt ................................................ 20 c. Risks from Endot hall Acid ................................................................................ 20 4. Risk to Endangered Species .................................................................................. 21 a. Risks from Use of Endothall N, N - dimethylalkylamine Salt ............................ 21 b. Risks from Use of Endothall Dipotassium Salt ................................................ 22 iii

### IV. Risk Management, Reregistration, and Tolerance Reassessment Decision ............... 22 A. Determination or Reregistration Eligibility ............................................................. 22 B. Public Comments and Responses ............................................................................. 23 C. Regulatory Position .................................................................................................. 23 1. Food Quality Protection Act Findings .................................................................. 23 a. "Risk Cup" Determination ................................................................................ 23 b. Determination of Safety to U.S. Population (Including Infants and Children) 24 c. Endocrine Disruptor Effects .............................................................................. 24 d. Cumulative Risks .............................................................................................. 25 2. Tolerance Summary .............................................................................................. 25 a. Tolerances Currently Listed and Tolerance Reassessme nt ............................... 27 D. Regulatory Rationale ................................................................................................ 28 a. Dietary Risk Mitigation (food and drinking water) .......................................... 28 1. Human Health Risk Management ......................................................................... 29 a. Occupational Risk Mitigation ........................................................................... 29 b. Residential Risk Mitigation .............................................................................. 29 2. Environmental Risk Management ......................................................................... 30 a. Dipotassium Salt ............................................................................................... 30 b. N , N- dimethylalkylamine Salt .......................................................................... 30 3. Significance of Endothall Use ............................................................................... 30 4. Other Labeling Requirements ............................................................................... 31 5. Threatened and Endangered Species Considerations ............................................ 32 a. The Endangered Species Program..................................................................... 32 b. General Risk Mitigation.................................................................................... 32 V. What Registrants Need to Do ....................................................................................... 33 A. Manufacturing Use Products .................................................................................... 34 1. Additional Generic Data Requirements ................................................................ 34 2. Labeling for Technical and Manufacturing Use Products .................................... 35 B. End - Use products ..................................................................................................... 36 1. Additional Product - Specific Data Requirements .................................................. 36 2. Labeling for End - Use Products ............................................................................. 36 a. Label Changes Summary Table ........................................................................ 36 VI. Appendices .................................................................................................................. 47 A. Table of Use Patterns for Endothall ............................................................................. 48 B. GenericData Requirements and Studies Used to Make the Reregistration Decision 63 C. Technical Support D ocuments ................................................................................. 70 D. Bibliography ............................................................................................................. 73 E. Generic Data Call - In ............................................................................................... 154 F. Product Specific Data Call - In ................................................................................. 177 G. EPA's Batching of Endothall Products for Meeting Acute Toxicity Data Requirements for Reregistration ................................................................................. 204 H. List of Registrants Sent Data Call - Ins .................................................................... 206 I. List of Available Related Documents and Electronically Available Forms ............ 207

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### Endothall Reregist ration Eligibility Decision Team Special Review and Reregistration Division Mika J. Hunter Anne Overstreet Robert McNally Health Effects Division Robert Zendzian David Soderberg Sey ed (Nader) Tadayon Louis (Gino) Scarano Environmental Fate and Effects Division Michelle Embry Michael Davy Dana Spatz Antimicrobial Division Kathryn Montaque Timothy Leighton Biological and Economic Analysis Division Bill Phillips TJ Wyatt Steve Jar boe Registration Division Joanne Miller Jim Stone

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### Glossary of Terms and Abbreviations AGDCI ai aPAD BCF CFR cPAD CSF CSFII DCI DEEM DFR DNT EC EDWC EEC EPA EUP FDA FIFRA FFDCA FQPA GLN IR LC 50 LD 50 LOC LOAEL MATC μg/g μg/L mg/kg/day mg/L MOE MRID MUP NOAEL OPP OPPTS PAD PCA PDP PHED PHI ppb PPE ppm Agricultural Data Call - In Active Ingredient Acute Population Adjusted Dose Bioconcentrati on Factor Code of Federal Regulations Chronic Population Adjusted Dose Confidential Statement of Formulation USDA Continuing Surveys for Food Intake by Individuals Data Call- In Dietary Exposure Evaluation Model Dislod geable Foliar Residue Developmental Neurotoxicity Emulsifiable Concentrate Formulation Estimated Drinking Water Concentration Estimated Environmental Concentration Environmental Protection Agency End - Use Product Food and Drug Administration Federal Insecticide, Fungicide, and Rodenticide Act Federal Food, Drug, and Cosmetic Act Food Quality Protection Act Guideline Number Index Reservoir Median Lethal Concentration. A statistically deriv ed concentration of a substance that can be expected to cause death in 50% of test animals. It is usually expressed as the weight of a substance per weight or volume of water, air, or feed, e.g., mg/l, mg/kg, or ppm. Median Lethal Dose. A statisti cally derived single dose that can be expected to cause death in 50% of the test animals when administered by the route indicated (oral, dermal, inhalation). It is expressed as a weight of substance per unit weight of animal, e.g., mg/kg. Level of Co ncern Lowest Observed Adverse Effect Level Maximum Acceptable Toxicant Concentration Micrograms Per Gram Micrograms Per Liter Milligram Per Kilogram Per Day Milligram Per Liter Margin of Exposure Master Record Identification Number. EPA's system for recording and tracking studies submitted. Manufacturing - Use Product No Observed Adverse Effect Level EPA Office of Pesticide Programs EPA Office of Prevention, Pesticides, and Toxic Sub stances Population Adjusted Dose Percent Crop Area USDA Pesticide Data Program Pesticide Handler's Exposure Data Pre -harvest Interval Parts Per Billion Personal Protective Equipment Parts Per Million 

### iiPRZM/EXAMS RAC RED REI RfD RQ SCI - GROW SAP SF SLC TGAI USDA USGS UF UV WPS Tie r II Surface Water Computer Model Raw Agriculture Commodity Reregistration Eligibility Decision Restricted Entry Interval Reference Dose Risk Quotient Tier I Ground Water Computer Model Science Advisory Panel Safe ty Factor Single Layer Clothing Technical Grade Active Ingredient United States Department of Agriculture United States Geological Survey Uncertainty Factor Ultraviolet Worker Protection Standard



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### Abstract This document presents the Environmental Protection Agency's (hereafter referred to as EPA or the Agency) decision regarding the reregistration eligibility of the registered uses of endothall. The Agency has determin ed that endothall is eligible for reregistration. Endothall is used as an aquatic herbicide, a desiccant, and a biocide. Endothall is applied as either the dipotassium salt or the N, N - dimethylalkylamine salt. There are currently seven tolerances estab lished for endothall. The Agency has conducted human health and environmental fate and ecological effect risk assessments for endothall and reassessed all the existing tolerances. The risk conclusions of these assessments are summarized below. In the h uman health risk assessment, chronic dietary risks (food and drinking water) do not exceed the Agency's level of concern, although drinking water risk for infants less than one year old is at the level of concern. However, the Agency believes that this risk estimate is the result of conservative assumptions and is discussed in detail in section III.5 of this document. Aggregate risks (food, drinking water, and residential exposure) also do not exceed the Agency's level of concern. To ensure that endothal l exposures from drinking water do not result in risks of concern, the Agency is requiring that direct applications to water not be applied less than 600 feet from an active drinking water intake. For terrestrial uses of endothall, all risks calculated f or short - term and intermediate - term occupational exposures are below the Agency's level of concern with the exception of mixing and loading liquids for aerial applications. The Agency is requiring that workers mixing and loading liquids for aerial applications wear an 80% (PF5) respirator (NIOSH TC - 21C). All risks for short- term and intermediate - term exposures from mixing, loading, and applying liquid formulations to aquatic use sites are below the Agency's level of concern when workers wear an 80% (PF5) respirator (NIOSH TC - 21C). All risks for short- term exposures from loading and applying granular formulations for aquatic applications are below the Agency's level of concern when workers wear baseline protective equipment. For intermediate - term exposure s from loading and applying granular formulations for aquatic applications, risks are of concern to the Agency. To protect workers in this scenario, workers are required to wear a 90% respirator (PF10 elastomeric half - face respirator with the appropriate cartridge, NIOSH TC - 23C or NIOSH TC - 14G). All occupational risks from use of endothall as a biocide in cooling towers are below the Agency's level of concern. Technical endothall is classified as a severe dermal irritant. However, this regulatory decis ion does not include specific mitigation to address these dermal effects. Appropriate worker protections and label language will be established based on end - use product acute toxicity during product reregistration. Product reregistration follows active ingredient reregistration. A 48 - hour re - entry interval is currently on labels for terrestrial uses and will be retained. In addition, a double notification statement to further protect workers will be added to endothall labels intended for terrestrial use . iv

### Ecological risks were identified as a result of endothall use in terrestrial and aquatic settings. To potentially reduce risks to non - target plants and organisms, the Agency is requiring that endothall labels differentiate application rates for smalland large applications of endothall dipotassium salt. Labels will specify that higher rates are only to be used for small, spot treatments, and lower rates are to be used for larger treatments. In addition, the use of N, N - dimethylalkylamine salt in lakes, streams, and ponds will be limited to algae, Hygrophila, Vallisneria, Hydrilla, Cabomba, bur - weed, Elodea canadensis, and Brazilian elodea .

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### I. Introduction The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) was amended in 1988 to accelerate the reregistration of products with active ingredients registered prior to November 1, 1984 and amended again by the Pesticide Registration Improvement Act of 2003 to set time frames for the issuance of Reregistra tion Eligibility Decisions. The Act calls for the development and submission of data to support the reregistration of an active ingredient, as well as a review of all submitted data to the U.S. Environmental Protection Agency (EPA or the Agency). Reregis tration involves a thorough review of the scientific database underlying a pesticide's registration. The purpose of the Agency's review is to reassess the potential hazards arising from the currently registered uses of a pesticide; to determine the need f or additional data on health and environmental effects; and to determine whether or not the pesticide meets the "no unreasonable adverse effects" criteria of FIFRA. On August 3, 1996 the Food Quality Protection Act of 1996 (FQPA) was signed into law. This Act amended FIFRA and the Federal Food Drug and Cosmetic Act (FFDCA) to require reassessment of all existing tolerances for pesticides in food. FQPA also requires EPA to review all tolerances in effect on August 3, 1996 by August 3, 2006. In reassessing these tolerances, the Agency must consider, among other things, aggregate risks from non - occupational sources of pesticide exposure, whether there is increased susceptibility among infants and children, and the cumulative effects of pesticides that ha ve a common mechanism of toxicity. When the Agency determines that aggregate risks are not of concern and concludes that there is a reasonable certainty of no harm from aggregate exposure, the tolerances are considered reassessed. EPA decided that, for t hose chemicals that have tolerances and are undergoing reregistration, tolerance reassessment would be accomplished through the reregistration process. As mentioned above, FQPA requires EPA to consider "available information" concerning the cumulative effects of a particular pesticide's residues and "other substances that have a common mechanism of toxicity" when considering whether to establish, modify, or revoke a tolerance. Potential cumulative effects of chemicals with a common mechanism of toxicit y are considered because low- level exposure to multiple chemicals causing a common toxic effect by a common mechanism could lead to the same adverse health effect as would a higher level of exposure to any one of these individual chemicals. For informatio n regarding EPA's efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see the policy statements released by EPA's Office of Pesticide Programs concerning common mechanism determ inations and procedures for cumulating effects from substances found to have a common mechanism on EPA's website at http://epa.gov/pesticides/cumulative/. The Agency has found no information indicating endothall shares a common mechanism of toxicity with other substances. Endothall does not appear to 1

### produce a toxic metabolite produced by other substances. Therefore, for the purposes of tolerance reassessment and a decision on reregistration eligibility, EPA has not assumed that endothall shares a commo n mechanism of toxicity with other compounds. In the future, if additional information suggests endothall shares a common mechanism of toxicity with other compounds, additional testing may be required and a cumulative assessment may be necessary. This do cument presents EPA's revised human health and ecological risk assessments, its progress toward tolerance reassessment, and the reregistration eligibility decision for endothall. The document consists of six sections. Section I contains the regulatory fr amework for reregistration/tolerance reassessment. Section II provides a profile of the use and usage of the chemical. Section III gives an overview of the revised human health and ecological risk assessments based on data, public comments, and other inf ormation received in response to the preliminary risk assessments. Section IV presents the Agency's reregistration eligibility and risk management decisions. Section V summarizes label changes necessary to implement the risk mitigation measures outlined in Section IV. Section VI provides information on how to access related documents. Finally, the Appendices list related information and supporting documents. The preliminary and revised risk assessments for endothall are available in the Public Docket, under docket number OPP - 2004 - 0370 and on the Agency's web page, http://www/epa.gov/edockets. II. Chemical Overview Endothall is in the dicarboxylic acid class of chemicals. Endothall is applied as either a dipotassium salt or an N, N - dimethylalkylamine salt. Endothall acid is not directly applied to use sites; it is formed as a breakdown product resulting from application of the salt forms. The amine salt is the only form applied terrestrially, while both the dipotassium and amine salt are applied to aquatic use sites. The amine salt is also used to control algae and invasive mollusks in cooling towers. The majority of endothall is used in aquatic environments. Endothall acid is a selective contact herbicid e. Endothall acid works by interfering with plant respiration, by affecting protein and lipid biosynthesis, and by disrupting plant cell membranes.

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### A . Endothall and Salts Nomenclature Endothall, acid Molecular Formula C 8 

### H 10 

### O5 

### CAS Name 7 - oxabicyclo[2.2.1]heptane - 2,3 - dicarboxylic acid CAS Number 145 - 73 - 3 PC Code 038901 Endothall, dipotassium salt Molecular Formula C 8 

### H 8 

### K 2

### O 5 

### CAS Name N/A CAS Number 2164 - 07 - 0 PC Code 038904 Endothall, mono - N,N - dimethylalkylamine salt Molecular Formula C 10 

### H 17

### NO5 

### CAS Name N/A CAS Number 66330 - 88 - 9 PC Code 038905 B . Use Sites

• Endothall is used as an aquatic herbicide to control submerged aquatic vegetatio n and algae in lakes, ponds, and irrigation canals.

• Endothall is also used as a desiccant on potatoes, hops, cotton, clover, and alfalfa. Tolerances are established for sugar beets and rice straw, although current labels do not allow applications to th ese crops.

• Endothall has one biocide use to control mollusks and algae in cooling towers/systems. C

. Formulations

• Formulated as either a granular or a soluble concentrate (liquid). D . Methods of application

• For aquatic applications, endothall dipotassium salt and endothall N, N dimethylalkylamine salt can be applied as a granular or a liquid. Granular applications are made using centrifugal or blower- type spreaders that are mounted to boats. Granular formulations can also be applied to aquatic sites by spreader equipment attached to helicopters. Liquid applications are made using low pressure hand wand sprayers, hand - gun sprayers, or 3

### direct metering s ystems. Aerial application of liquids to aquatic sites is prohibited.

• For terrestrial applications, endothall is applied as a liquid. Terrestrial liquid applications can be made with either ground or aerial equipment. Only endothall N, N - dime thylalkylamine salt is used on terrestrial sites. E

. Use rates

• Maximum single application rates are 5 ppm for aquatic applications and 2 lbs acid equivalents/Acre for terrestrial applications. Application rates of both the salt forms of endothall are expressed as acid equivalents (ae) to equalize the application rates in terms of the acid. F. Annual usage

• In terms of pounds used, endothall is most readily used as an aquatic herbicide. For terrestrial endothall uses, the majority of use is on potatoes (approximately 5% crop treated) and cotton (less than 2.5% crop treated). Of the two forms of endothall, the N, N - dimethylalkylamine salt accounts for the most use. G. Toler ances in Use Profile

• There are currently five tolerances for endothall and its salts listed in CFR § 180.293(a)(1) on cotton seed (0.1 ppm), hops (0.1 ppm), potato (0.1 ppm), rice grain (0.05 ppm), and ri ce straw (0.05 ppm). One tolerance is listed in CFR § 180.319 for sugar beets (0.2 ppm).

• A tolerance is currently listed for potable water (0.2 ppm, CFR § 180.293(a)(2). The Agency is proposing that this tolerance be revoked. Currently, EPA’s Officeof Water has an MCL established for endothall.

• The Agency is proposing tolerances for cotton gin byproducts, animal commodities, processed commodities, and irrigated crops. When acceptable data are received these tolerances will be established . • The registrant has proposed tolerances for fish and shellfish. This action is not incorporated into this document and will be addressed in a separate action. However, a fresh water finfish residue level of 0.1 ppm was included in the dietary exposur e assessment. Current food consumption models cannot include residues in freshwater shellfish adequately; so freshwater shellfish were not incorporated into the current assessment, and were considered as a negligible source of residues.

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### H . Technical Registrant • Cerexagri, Inc. III. Summary of Risk Assessment A. Human Health Risk Assessment 1. Haz ard Profile (For a complete discussion, see section 4 of Endothall: HED Chapter of the Reregistration Eligibility Decision Document, Corrected Following Pub lic Comments, dated September 30 , 2005.) The toxicological database for endothall is considered complete. Endothall is Toxicity Category I by the oral, and ocular routes, and is a skin sensitizer. For dermal and inhalation toxicity, endothall is categorized as mildly toxic. For dermal exposure, a toxicity endpoint was not identified, and a dermal risk assessment was not conducted since endothall is so toxic at the portals of entry and is therefore self - limiting. In the 21 - day dermal toxicity study, in addition to weight loss, severe local effects were obser ved at the lowest dose tested, 30 mg/kg/day. Total body weight gain was also inhibited. The study indicated that systemic and local effects were co - occurant. Therefore, the Agency has determined that endothall will be classified as a severe dermal irritant. Label requirements addressing dermal effects through double notification will be placed on technical and end - use products. End - use products generally contain a lower percentage of active ingredient and it is appropriate to consider additional label requirements relating to endothall's dermal effects during product reregistration. Endothall is not a neurotoxicant, nor does it induce developmental toxicity. Endothall is classified as "not likely to be carcinogenic to humans" and has no mutagenic pote ntial. Endothall does not bioaccumulate. Table 1. Acute Toxicity Data for Endothall Guideline Number Study Type MRID Number Toxicity Category 870.1100 Acute Oral Toxicity 42289201 I 870.1200 Acute Dermal Toxicity 42289202 III 870.1300 Acute InhalationToxicity 42169501 II 870.2400 Acute Eye Irritation 42289203 I 870.2500 Acute Dermal Irritation 42289204 (unacceptable) Ia 870.2600 Skin Sensitization 41871901 Yes a. Endothall has been shown to be a skin irritant in a preliminary range finding study f or the dermal absorption study (42169503) and the 21 - day dermal toxicity study (43465201). This information is considered sufficient to classify endothall as a severe dermal irritant. 

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### Although endpoints for all exposure scenarios were selected from the same study, it is important to note that for each scenario, different toxicity endpoints are appropriate. The two short - term exposure scenarios (1 - 30 days, incidental oral and short - term inhalation) use a separate endpoint (NOAEL of 9.4 mg/kg/day) based on decreases in body weight in offspring of endothall - treated parents. The remaining, longer- term scenarios use a more conservative value (LOAEL of 2 mg/kg; divided by 3 to extrapolate to an estimated NOAEL of 0.7 mg/kg) to accommodate the longer exposure scenarios. Because an inhalation study is not currently available (a 28 - day inhalation study is being required), the inhalation exposure scenario uses an oral study assuming 100% absorption. Table 2. Summary of Toxicological Doses and Endpoints for End othall Used in the Human Health Risk Assessment Exposure Scenario Dose Used in Risk Special FQPA SF* Study and Toxicological Assessment, UF and Level of Concern Effects for Risk Assessment Acute Dietary An appropriate endpoint attributab le to a single dose was not available from any (All Populations) study, including the prenatal developmental toxicity study in rats. An acute RfD was not established. Chronic Dietary (All Populations) LOAEL = 2 2 mg/kg/day FQPA SF = 1X cPAD = 2- generation reproduction study in rats chronic RfD UF = 300 FQPA SF LOAEL of 2 mg/kg/day based (10X for intraspecies on proliferative lesio ns of the variations, 10X fo r = 0.007 mg/kg/day gastric epithelium in both sexes. interspecies differences, and 3X (MRID 43152101) for extrapolation from LOAEL to NOAEL) Chronic RfD = 0.007 mg/kg/day Short - term NOAEL=9.4 1 Residential MOE = 100 2- generation reproduction stud y Incidental Oral mg/kg/day in rats (1 - 30 days) UF = 100 LOAEL of 60 mg/kg/day based (10X for intraspecies on decreased pup body weight variations, 10X for in both sexes on Day 0 of interspecies second and third generations. differences) (MRID 43152101) Intermediate - term Incidental Oral (1 - 6 months) LOAEL= 2 2 mg/kg/day Residential MOE = 300 2- generation reproduction study in rats UF = 300 (10X for intraspecies variations, 10 X for LOAEL of 2 mg/kg/day based on proliferative lesions of the gastric epithelium in both sexes. interspecies differences, and 3X for extrapolation (MRID 43152101) from LOAEL to NOAEL) 

### 6Exposure Scenario Dose Used in Risk Special FQPA SF* Study and Toxicological Assessment, UF and Level of Concern Effects for Risk Assessment Sh ort - term NOAEL=9.4 1 Residential MOE = 100 2- generation reproduction study Inhalation mg/kg/day in rats (1 - 30 days) Occupational MOE = UF= 100 100 LOAEL of 60 mg/kg/day based (10X for intraspecies on decreased pup body weight variations, 10X for (both sexes) on Day 0 in both interspecies F1 and F2 generations. differences) (MRID 43152101) (inhalation absorption rate is assumed to be 100% of oral dose; default assumption) Intermediate - Term Inhalation LOAEL = 2 2 mg /kg/day Residential MOE = 300 2- generation reproduction study in rats (1 - 6 months) and Long - Term Inhalation UF = 300 (10X for intraspecies Occupational MOE = 300 LOAEL of 2 mg/kg/day based on prolif erative lesions of the variations, 10X for interspecies differences, and 3X gastric epithelium in both sexes. (MRID 43152101) for extrapolation from LOAEL to NOAEL) Cancer (oral, Classified as “not likely to be carcinogenic to humans” dermal, inhalation) (MRID 41040301, 40685301, 43608301) UF= uncertainty factor, FQPA SF = Special FQPA safety factor, LOAEL = lowest observed adverse effect level, PAD = population adjusted dose (c = chronic), RfD = reference dose, MOE = margin of exposure 1. The NOAEL of 9.4 mg/kg/day is derived from the offspring LOAEL of 60 mg/kg/day for the endpoint reference d in the table. 2. The LOAEL of 2 mg/kg/day is derived from the parental LOAEL of 2 mg/kg/day for the endpoint referenced in the table. 

### 2. Dietary Risk (Food) (For a complete discussion, see Section 6.0 of E ndothall: HED Chapter of the Reregistration Eligibility Decision Document, Corrected Following Pub lic Comments, dated September 30 , 2005.) The dietary risk assessment incorporates both exposure to and toxicity of a given pesticide. The risk is expresse d as a percentage of a maximum acceptable dose (i.e., the maximum dose which will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the Reference Dose (RfD) dividedby the special FQPA Safety Factor. EPA is concerned when estimated dietary risk exceeds 100% of the PAD. The endothall dietary risk assessment was performed using the Dietary Exposure Evaluation Model (DEEM TM 

### ). Table 2 above lists the endpoints used in the dietary risk assessment. 7

### The Special FQPA Safety Factor was reduced to 1X because there are no residual exposure uncertainties, no sensitivity to infants and children, and the toxicity database is essentially complete. The uncertainty factor (UF) for chronic dietary exposure to endothall was determined to be 300. This takes into consideration a factor of 10X for interspecies variation, 10X for intraspecies variation, and 3X for the lack of a NOAEL in the study used for endpoint selection. When eva luating the toxicological database for endothall, the primary effects are seen at the point of entry (i.e., oral) and the weight of evidence suggests that endothall will be of no developmental concern. This evidence includes the results of a developmental toxicity study with rats, where endothall did not induce developmental toxicity at any of the doses tested. Effects that were observed in developmental toxicity studies (decreased pup weight gain) are not considered to be developmental toxicity effects. Therefore, no additional uncertainty factors were added for the lack of a rabbit developmental toxicity study. However, a rabbit developmental toxicity study is being required as confirmatory data. Endothall metabolism results in either the formation of the monomethyl ester or complete decomposition into natural constituents of plant and animal tissues. The residues of concern in plants and animals are endothall and its monomethyl ester. a. Acute Dietary Risk (Food ) No endpoint was identified for acute dietary exposures because the acute toxicity database is complete and does not suggest there is a potential acute risk concern. Normally, an acute hazard value is chosen from acute (non - lethal), sub chronic, or developmental toxicity studies from which there is reasonable evidence that a single exposure can lead to a potential effect. Endothall is known to cause primarily local effects depending on the route of exposure. In the developmental rat stu dy, there was evidence of a decrease in body weight gain in pregnant rats after a single exposure of endothall. However, this effect was coupled with a decrease in food consumption and the treated rats recovered by the end of gestation. At all time point s, there was no difference in treated versus control body weights. Therefore, the available data suggests that a single exposure to endothall does not result in an effect of concern for risk assessment purposes. The Agency does not expect acute risks res ulting from dietary exposure. b. Chronic Dietary Risk (Food) The chronic dietary risk endpoint for all populations was selected from the two generation reproduction toxicity study using rats as the test subject. The endpoint of concern was proliferate lesions of the gastric epithelium, which was observed in both sexes. The Lowest Observed Adverse Effect Level (LOAEL) is 2 mg/kg/day in males and 2.3 mg/kg/day in females. For the chronic dietary e xposure assessment, an estimate of the residue level in each food or food - form on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food - form. The resulting residue consumption 8

### estimate is summed with th e residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and risk is expressed as a percent of the chronic PAD (cPAD). F ood items may be exposed to residues of endothall in two ways: via direct application, or via irrigation water previously treated with endothall. To assess residues on food from the two uses, two assessments were performed. One assessment took into consi deration only exposure to crops that are directly treated with endothall. The second assessment incorporated exposure to crops directly treated with endothall and crops that were irrigated with endothall - treated water. To assess exposures from both of th ese scenarios, a DEEM TM 

### analysis was performed. The results of the DEEM TM 

### analysis using exposure from only directly treated crops was 1.2% of the cPAD for the general population. The most highly exposed population subgroup was children 3 - 5 years old wi th an exposure estimate of 3.0% of the cPAD. These results are based on tolerance level residues and 100% crop treated and are considered to be conservative estimates of chronic dietary risk. When calculating residues on crops irrigated with endothall - t

reated water, an assumption that all crops are irrigated with water containing endothall was initially used directly in the DEEM TM 

### program. This assumption led to an overestimate of exposure from irrigated crops. Using the amount of endothall produced pe r year, and information from the U.S. Geological Survey concerning irrigation practices, the Agency was able to refine exposure estimates. To conservatively address errors in this estimation and to assure that regional and crop differences in irrigation, and differences in consumption of crops are taken into consideration, a percent of the crops irrigated with treated irrigation water was conservatively estimated to be 1%. The actual increase in exposure to endothall through irrigation should be less than 1% of that originally estimated by DEEM TM 

### . Therefore, the results from the DEEM TM 

### analysis for the portion of exposure due to irrigated crops were multiplied by a factor of 0.01. The results of the DEEM TM 

### exposure analysis for exposure from directly tre ated crops and irrigated crops was 2.7% of the cPAD for the general population, and 7.8% cPAD for children 1 - 2 years old. Therefore, chronic dietary risks (food) are below the Agency's level of concern. For a complete discussion of exposure to endotha ll from consumption of irrigated crops, please see "Endothall and its salts: Addendum to Chronic Dietary Exposure Assessment for the Reregistration Eligibility Decision", dated September 29, 2005.

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### Table 3. Summary of Chronic Dietary Exposure and Risk from Endothall (Directly Treated Crops and Crops Irrigated with 5 ppm Endothall) Population Subgroup Dietary Exposure % cPAD mg/kg/day 

### General U.S. Population 0.000189 2.7 Children 1 - 2 years old 0.000544 7.8 

### 3. Cancer Dietary Risk (Food) The Agency has classified endothall as "not likely to be carcinogenic to humans" based on the lack of evidence of carcinogenicity in mice or rats. 4. Drinking Water Dietary Risk (For a complete discussion, see Section 6.2 of the Endothall: HED Chapter of the Reregistration Eligibility Decision Document, Corrected Following Pub lic Comments, dated September 30 , 2005.) Drinking water exposure to pesticides can occur through groundwater and surface water contamination. EPA considers both acute (one day) and chronic (lifetime) drinking water risks and uses either modeling or actual monitoring data, if available, to estimate those risks. For endothall, only non - cancer chronic dietary exposure from drinking water was assessed. As previously stated, an endpoint for acute dietary exposure was not identified and acute dietary risks are not of concern to the Agency. For endothall, drinking water exposure takes into consideration potential exposure from terrestrial, aquatic, a nd industrial (biocide) uses. Also, endothall is considered "not likely to be carcinogenic in humans". a. Aquatic Uses Direct applications to water weremodeled assuming uniform application over an entire reservoir at the maximum labeled rate. Based on these assumptions, the peak (acute) concentration of endothall in surface water was estimated to be 5000 μg/L, and the annual mean (chronic) concentration was estimated to be 545 μg/L. EPA believes it is highly unlikely that concentrations of endothall would reach these levels in areas where surface water is directly used for drinking water for several reasons: • The assumption that 100% of a water body is treated with endothall at the maximum label rate is conservative and highly unlikely. Typically, endothall is applied as a peripheral treatment around boat docks and piers, so that only a small percentage of a water body is treated. • Endothall treatments are made to the upper 3 to 5 feet of the water body, whereas drinking water intakes are typically located at the deepest point in municipal reservoirs where endothall concentrations would be expected to be lower. 10

### • Monitoring data for endothall suggest the average concentrations of endothall in drinking water are well below the modeled estimates. Monitoring data for finished water are available from the National Contaminant Occurrence Database (NCOD) for both surface and ground water. Detectable residues of endothall were found in only 7 of 27,494 or 0.025% of ground water samples and 8 of 5,112 or 0.15% of surface water samples. The maximum detected concentrations in ground and surface water were 4,550 ppb and 2,900 ppb, respectively; and the mean conce ntration for samples with detectable residues was 670 ppb in ground water and 865 ppb in surface water. Although these few values are well above the established Maximum Contaminant Level (MCL) for endothall of 100 ppb, greater than 99% of ground and surfa ce water samples contained concentrations below the limit of detections (10 ppb). Endothall may be applied to water at concentrations up to 5000 ppb. These high values would not be representative of average concentrations in drinking water. This determi nation is further supported by additional monitoring data collected under the Safe Drinking Water Act (SDWA). Data collected under the Safe Drinking Water Information System (SDWIS) between 1993 and 2005 indicated only 2 occurrences of endothall residues that exceeded the established MCL of 100 ppb. Both of these occurred in 1994, with no violations occurring since that time. In addition, historical data analysis of compliance and occurrence data from treated water systems has shown detections of very lo w frequency to be outliers relative to whole datasets. Given the low frequency of detection and the more than an order of magnitude difference between the more than 27,000 samples below the detection limit and 8 detects above, the observed detects would appear to be statistical outliers. For these reasons, EPA does not believe the modeled estimated concentrations are appropriate for use in estimating exposure to endothall in drinking water. As noted above, an MCL of 100 ppb has been established for endo thall. The MCL is based on a chronic feeding study which established a NOEL of 2 mg/kg/day based on increased absolute relative weights of the stomach and small intestine. Although the MCL is likely to overestimate average (i.e., chronic) residues of end othall in drinking water, EPA believes it provides a reasonable high - end estimate of potential drinking water concentrations from the aquatic uses of endothall. Consequently, the MCL of 100 ppb was used in the dietary risk assessment.

11

### b. Terrestr ial Uses Surface water concentrations from use on terrestrial crops were estimated using the Tier II model PRZM (version 3.12)/EXAMS (version 2.98.04) and ground water concentrations were estimated using the Tier Imodel of SCIGROW (version 2.2). A total of five scenarios were modeled for endothall use on terrestrial crops based on Agency standard scenarios. The scenarios modeled were cotton and alfalfa in California, Oregon hops, and potatoes in Maine and Idaho. These scenarios were chosen to estimate the concentration of endothall in surface drinking water over a geographically dispersed range of existing terrestrial crop production areas. These scenarios chosen for this assessment represent all relevant PRZM/EXAMS scenarios for the terrestrial use of endothall. Endothall may be applied by aerial or ground equipment as per the labels of this product. All terrestrial scenarios were modeled with aerial application equipment, which results in the highest amount o f spray drift, except for hops, which is treated by ground equipment. The estimated peak surface water concentration of endothall as a result of terrestrial use is 7.1 ppb. The estimated chronic (non - cancer) surface water concentration of endothall as a result of terrestrial use is 2.5 ppb. Modeled groundwater concentrations of endothall, both peak and chronic, are not expected to exceed 0.086 ppb. 5. Chronic Risk from Food Plus Drinking Water To assess chronic risk from food plus drinking water, exposure estimates from both chronic dietary (both directly treated and irrigated crops) and chronic drinking water were combined in the DEEM TM 

### modeling program. Estimated concentrations o f endothall were modeled by the Agency as discussed above. Based on the rationale described above, the Agency assumed an endothall concentration of 100 ppb as the average concentration in drinking water. This concentration is the MCL for endothall. Beca use the Agency feels that modeled concentrations are not appropriate for use in estimating exposure to endothall in drinking water, the MCL of 100 ppb was used. Chronic dietary risks (food and drinking water) do not exceed the Agency's level of concern, although drinking water risk for infants less than one year old is at the level of concern. As previously discussed, t he Agency believes that this risk estimate is the res ult of conservative assumptions . Table 4. Summary of Dietary Exposure and Risk f rom Directly Treated Crops, Irrigated Crops, and Drinking Water Population Subgroup Dietary Exposure mg/kg/day % cPAD (Food + Water) General U.S. Population 0.002297 33 All Infants (<1 year old) 0.007234 103 Children 1 -2 years old 0.003574 51



### 12

### 6. R esidential Risk Endothall products may be used in residential settings to control aquatic weeds and algae in ponds and garden pools. Therefore, homeowners may potentially be exposed to endothall by applying home - u se formulations. In addition, there is also a potential for exposure to adults and children from incidental oral and dermal exposure during recreational activities in public waters treated with endothall. As a result, risk assessments were completed for both residential handlers and post - application scenarios. Residential risks are measured by a margin of exposure (MOE), which determines how close the exposure comes to a No Observed Adverse Effect Level (NOAEL) taken from animal studies. For residential risk from endothall, Margins of Exposure (MOEs) that are greater than or equal to 100 are below EPA’s level of concern for short - term residential exposures. Residential applications are only expected to occur over short - periods of time. Therefore, intermediate - term and long- term residential exposure assessments were not conducted. The anticipated use patterns that could potentially lead to residential handler exposure are: (1) loading/applying granular formulations with a belly grinder; and (2) applyin g granular formulations by hand. The exposure pathway of concern for residential handlers is short - term inhalation. The short - term inhalation NOAEL is 9.4 mg/kg/day based on decreased pup body weight. This endpoint is taken from the two - generation rat reproduction study. Short - term inhalation MOEs for loading/applying granular formulations with a belly grinder range from 190 to 830. For handlers applying granular formulations by hand, the short - term inhalation MOE is 2700. Therefore, residential hand ler risks are below the Agency's level of concern. For residential post - application exposures, exposures on the day of application after an application to a public water body are of the greatest concern. The Agency identified incidental oral exposure (f rom swallowing water while swimming) and the potential for dermal irritation while swimming as possible post - application exposure scenarios. The Agency conducted an assessment, using the SWIM modeling program, to assess incidental exposures. Risks were c alculated using MOEs, where an MOE greater than or equal to 100 is below EPA’s level of concern. The incidental oral endpoint for short- term exposure of 9.4 mg/kg/day was selected from a two - generation rat reproduction study (in which lesions in the gastr ic epithelium were observed). MOEs calculated for both children (ages 6 - 10) and adults are below the Agency's level of concern for incidental oral (280 and 900, respectively). The expected exposure to swimmers from the dermal route would be extremely low (the highest application rate results in a water concentration of 5 ppm) and would not likely result in any irritation to the skin. Currently, several Special Local Needs (SLN) labels have swimming restrictions that prohibit access to waters following co mmercial applications.

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### 7. Aggregate Risk (For a complete discussion, see Section 7.0 of the Endothall: HED Chapter of the Reregistration Eligibility Decision Document, Corrected Following Public Comments, date d S eptember 30 , 2005.) Aggregate exposure to a pesticide combines exposure from food, drinking water, and, if applicable, residential exposure. For endothall, aggregate risk was measured as a margin of exposure. MOEs for short- term residential exposures above or equal to the target level (100) are not of concern to the Agency. In the case of endothall, residential exposures are only expected to be episodic, or short - term. Therefore, intermediate - term and long- term residential exposures were not assesse d. For adult short- term aggregate exposure, EPA aggregated inhalation exposure during residential applications, oral exposure during swimming, and dietary exposure from food and drinking water. For children (ages 6 - 10), EPA considered incidental oral exposure during swimming and dietary exposure (food and drinking water). Although infants are the most sensit ive subgroup for chronic dietary concerns, the Agency did not find it appropriate to assume infants (less than one year old) participate in swimmin g activit iesin outdoor water bodies such as lakes and ponds . The MOEs calculated are above the target MOE, with values of 250 for children (ages 6 - 10) and 310 for adults (age 50 years and older). Therefore, short - term aggregate risks are below the Agenc y's level of concern. Because EPA does not expect chronic residential exposure, chronic aggregate risks are equal to chronic dietary risks (food plus water). As described above in Section 5, these risks are at the Agency’s level of concern. 8.Occ upational Risk (For a complete discussion, see the Revised Occupational and Residential Exposure Assessment and Recommendations for the Reregistration Eligibility Decision Document for Endothall, dated August 12, 2 005) . Workers can be exposed to a pesticide while mixing, loading, or applying a pesticide, and when entering a treated site. Handler and worker risks are measured by a margin of exposure (MOE), which determines how close the occupational exposure comesto a No Observed Adverse Effect Level (NOAEL) taken from animal studies. The Agency initially calculates the handler risks using the least protective measures. This is called the baseline assessment, and assumes an individual’s normal work clothing (e.g ., long sleeve shirt and long pants), no gloves, and no respirator. If there is a concern at this level, the Agency considers the use of protective measures (e.g., personal protective equipment and engineering controls) to lower the risk. Personal protec tive equipment (PPE) can include an additional layer of clothing, chemical - resistant gloves, and a respirator. Common examples of engineering controls include: enclosed tractor cabs, closed loading systems, and water- soluble packaging. 14

### a. Occupatio nal Handler Summary The Agency has determined that workers may be exposed to endothall while mixing, loading, applying, and flagging for aerial applications. In the absence of chemical - specific monitoring data for endothall, exposure analyses were performed using the Pesticide Handlers Exposure Database (PHED). The MOEs for occupational exposures were calculated for short - term and intermediate - term inhalation exposures for terrestrial, aquatic, and coo ling tower applications. For the short - term inhalation exposure scenario the NOAEL is 9.4 mg/kg/day. This endpoint is based on decreased pup body weight. For the intermediate - term inhalation exposure scenario the LOAEL is 2 mg/kg/day based on proliferat ive lesions of the gastric epithelium. Both endpoints for the inhalation exposure scenarios are taken from the two - generation oral rat reproduction study. Toxicity from dermal exposures was not assessed because a dermal endpoint was not established for systemic effects. End - use product labels will address protection for workers regarding dermal exposure. For occupational risks, short - term MOEs that are greater than 100 and intermediate - term MOEs that are greater than 300 do not exceed the Agency’s level of concern. The level of concern for short and intermediate - term exposures are based on 10X to account for interspecies extrapolation to humans from animal test species and 10X to account for intraspecies sensitivity. For intermediate - term exposures, an additional 3X is applied to account for the lack of a NOAEL. i.Terrestrial Applications All risks calculated for short- term inhalation exposure to mixers, loaders, and applicators are below the Agen cy's level of concern (MOEs range from 390 to 38,000) when wearing baseline attire. For intermediate - term inhalation exposure to mixers, loaders, and applicators, all risks are below the Agency's level of concern (MOEs range from 500 to 8,100 with baselin e attire) with the exception of mixing and loading liquids for aerial applications (MOEs range from 83 - 290 with baseline attire). ii.Aquatic Applications In the absence of specific occupational exposur e data for aquatic use scenarios, surrogate exposure scenarios were used to assess certain occupational scenarios. To assess exposure from mixing, loading, and applying liquid formulations for applications using boat- mounted spray equipment, the exposure scenario for mixing and loading liquids for ground boom equipment was used. To assess exposure from mixing and loading concentrate to direct metering/subsurface application equipment, the mixing and loading scenario for mixing and loading liquid formulati ons was used. To assess exposure from mixing, loading, and applying concentrate liquid formulations with a handgun sprayer, the lawn care operator (LCO) exposure information from the Outdoor Residential Exposure Task Force (ORETF) was used. Finally, to a ssess exposure from loading and applying granular formulations, the open loading granular application 15

### scenario was used from the Pesticide Handler Exposure Database (PHED). For aquatic exposures, MOEs were calculated using an 80% (PF5) respirator. Curren t labels require workers to wear this type of protection. All risks for short- term exposures from mixing, loading, and applying liquid formulations are below the Agency's level of concern when workers wear an 80% (PF5) respirator (NIOSH TC - 21C) (MOEs ran ge from 1150 to 130,000). All risks for intermediate - term exposures from mixing, loading, and applying liquid formulations are below the Agency's level of concern when workers wear an 80% (PF5) respirator (NIOSH TC - 21C) (MOEs range from 400 to 275,000) wi th the exception of mixing and loading liquids for ground - spray type applications at high rates (MOE = 250). However, although the MOE for this scenario does not reach the target of 300, it is unlikely that typical applications will result in a risk to wo rkers. For example, as part of this RED, the Agency is requiring aquatic labels to specify that applications at the highest rate are for spot treatments only. The exposure assessment for mixing and loading liquids assumed a treatment area of 30 acres. In addition, intermediate - term exposure assessments assume more than 30 days of exposure. It is unlikely that applications to large areas at high rates will be conducted for that length of time. As a result of these assumptions and the mitigation measure s set forth in this RED, the Agency believes that the 80% respirator will adequately protect workers for the above scenarios. All risks for short- term exposures from loading and applying granular formulations are below the Agency's level of concern (MOEs range from 208 to 860 with baseline attire). For intermediate - term exposure from loading and applying granular formulations, risks are of concern to the Agency (MOEs range from 220 - 240 with an 80% (PF5) respirator). iii. Cooling Tower (Biocide) Ap plications Occupational exposures were assessed for applications of endothall to cooling towers to control mollusks and algae. Labels indicate that endothall should be continuously fed into c ooling tower waters for 6 to 144 hours. Although a continuous feed is a daily operation, handlers treating water systems are expected to apply endothall on a limited basis and are best represented by short - term exposure duration. All short term inhalatio n risks for cooling tower uses are below the Agency's level of concern (MOEs range from 620 to 260,000). b. Post - application Occupational Risk The Agency did not assess occupational post - appli cation risks to agricultural workers following treatments to agricultural crops, because no systemic dermal endpoint of concern was established. Based on acute toxicity of the active ingredient and potential to cause severe dermal irritation, endothall is classified as a severe dermal irritant. However, a re - entry interval of 48 hours is required for agricultural workers. Postapplication occupational exposures following endothall applications to aquatic areas is 16

### likely limited to persons who contact the treated water to perform tests, or persons such as agricultural workers who may contact treated water in irrigation canals. 9. Human Incident Summary To assess occupational and non - occupation incidents, the Agency consults several incident reportin g databases. These include: the Office of Pesticide Program Incident Data System, Poison Control Centers, California Department of Pesticide Regulation, National Pesticide Telecommunications Network, and the National Institute of Occupational Safety and H ealth's Sentinel Event Notification System for Occupational Risks. Relatively few incidents of illness have been reported due to endothall. In general reports are of irritative effects to the eye and skin. No endothall related hospitalizations have b een reported due to pesticide use. No recommendations are made based on the very limited incident d ata available for endothall . B. Ecological Risk To estimate potent ial ecological risk, EPA integrates the results of exposure and ecotoxicity studies using the risk quotient method. Risk quotients (RQs) are a screening level for potential risk and are calculated by dividing exposure estimates by ecotoxicity values, both acute and chronic, for various wildlife species. RQs are then compared to levels of concern (LOCs). Table 5 lists levels of concern used in the risk assessment. Generally, the higher the RQ, the greater the potential risk. Risk characterization provides further information on the likelihood of adverse effects occurring by considering the fate of the chemical in the environment, communities and species potentially at risk, their spatial and temporal distributions, and the nature of the effects observed in studies. RQ values are provided in parentheses for indicated exceedances in the summary below. Table 5. Levels of Concern for Ecological Risk If RQ > LOC value given below... Then EPA presumes... Terrestrial Aquatic Plants Risk Presum ption Organisms Organisms 0.5 0.5 1 Acute Risk -there is potential for acute risk; regulatory action may be warranted in addition to restricted use classification 0.2 0.1 N/A Acute Restricted Use -there is potential for acute risk, but may be mitigated through restricted us e classification 0.1 0.05 1 Acute Endangered Species -endangered species may be adversely affected; regulatory action may be warranted 1 1 N/A Chronic Risk - there is potential for chronic risk; regulatory action may be warranted 

### 1.Environmental Fate and Transport 17

### (For a complete discussion, see the Environmental Fate and Ecological Risk Assessment of Endothall - Revised, dated April 22, 2005.) The endothall environmental risk assessment include s an assessment of risks to aquatic organisms from both the aquatic and terrestrial uses. Endothall is applied as either endothall dipotassium salt or endothall N,N - dimethylalkylamine salt. After application of either the dipotassium salt or N,N - dimethyl alkylamine salt, endothall acid is formed by degradation. The acid is the form of endothall that acts as an herbicide, desiccant, algaecide, and biocide. The three forms of endothall have dissimilar toxicity properties, with the endothall N,N - dimethylalky lamine salt being more toxic to aquatic animals than the dipotassium salt. However, the dipotassium salt and endothall acid have similar toxicity properties. The dissociation constants of both of the endothall salts indicate that at most environmental p H levels, the endothall salt, endothall acid, and the corresponding cation (potassium or coco - alkylamine) will be present. After aquatic applications, endothall salts, acid, and cation components will be found mainly in the water column. The potassium io ns that dissociate from the dipotassium salt are not of concern as a source for additional toxicity. The persistence of endothall acid in aqueous environments is expected to be less than ten days. In terrestrial environments, endothall acid degrades with a half - life of approximately ten days. The half - lives of the endothall N,N dimethylalkylamine salt and the coco - amine have not been provided. The environmental risk assessment is organized by risks posed by each form of endothall. Therefore, the fol lowing sections are also organized in that manner. 2. Terrestrial Organism Risk (For a complete discussion, see the Environmental Fate and Ecological Risk Assessment of Endothall - Revised, dated April 2 2, 2005.) a. Risks from Use of Endothall N, N - dimethylalkylamine Salt The N,N - dimethylalkylamine salt form of endothall is the only form used terrestrially. In terrestri al scenarios, in addition to the presence of N,N dimethylalkylamine salt, it is possible that the degradation products (endothall acid and coco - alkylamine cation) will be present. As a result of exposure to these compounds several groups of organisms are potentially at risk. Acute mammalian LOCs are exceeded from use on all terrestrial sites (RQs range from 0.12 to 9.74). Based on endothall acid chronic toxicity, birds feeding on grasses, broad leaf plants, and small insects are potentially at risk from the use of N, N - dimethylalkylamine salt on potatoes, hops, alfalfa, and clover (RQs range from 1.02 to 9.10). Chronic RQs for birds are based on early embryonic mortality. From use on alfalfa, clover, potatoes, and hops chronic LOCs for mammals are excee ded (RQs range from 1.04 to 3.03). Chronic RQs for mammals are based on decreased pup body weight and death of animal within one day. 18

### Because endothall is a herbicide, non - target plants are potentially at risk from drift and runoff of endothall N,N - dime thylalkylamine salt away from target use sites. LOCs are exceeded for non - target plants caused by adjacent runoff and wetland area runoff from applications made to potatoes, hops, alfalfa, clover, and cotton (RQs range from 2.3 to 27.5). LOCs for acute a lgae toxicity are also exceeded for terrestrial use of N, N- dimethylalkylamine salt (RQs range from 1 to 7.65). The Agency feels that potential risks to terrestrial organisms from the N, N dimethylalkylamine salt may have been underestimated because terrestrial RQs were based on toxicity data using endothall acid and endothall dipotassium salt. Available ecotoxicity studies using the N, N - dimethyalkylamine salt indicate it is more toxic to organisms than dipotassium salt or endothall acid. Additional dat a pertaining to the fate and ecotoxicity of the N, N - dimethylalkylamine salt is being requested. 3. Aquatic Organism Risk The RQs presented below are representative of RQs resulting from a range of appl ication rates for aquatic use. The rates that were used in the assessment included 0.5, 1.0, 2.5, 3, 4, and 5 ppm. A range of application rates was used in order to compare RQs at low, average, and maximum application rates. Although the assessment w as performed using very high end label rates, typical rates used to control algae and plants are low, 0.05 - 0.3 ppm and 1 - 3 ppm, respectively. Therefore, RQs calculated at rates above 3 ppm are conservative expressions of risk and represent exposure scenar ios that are infrequent. a. Risks from Use of Endothall N, N - dimethylalkylamine Salt The N,N - dimethylalkylamine salt form of endothall is more toxic than other forms of e ndothall (2 to 3 orders of magnitude) to aquatic organisms, both on an acute and chronic basis. On an acute basis, the N,N - dimethylalkylamine salt is considered to be highly toxic to very highly toxic to freshwater fish, moderately toxic to highly toxic t o estuarine/marine fish, and moderately toxic to very highly toxic to estuarine/marine invertebrates. Acute LOCs are exceeded for freshwater and marine fish (RQs range from 0.6to 119), invertebrates (RQs range from 3 to 417), vascular plants (RQs range f rom 2 to 7), and algae (RQs range from 217 to 2174) from all direct applications to water, including once - through cooling tower uses. Chronic LOCs are exceeded for freshwater fish (RQs range from 2.2 to 22.2) and invertebrates (RQs range from 133 to 1331. 3) from all direct applications to water, including once - through cooling tower uses. For freshwater fish, chronic RQs are based on survival, and for freshwater invertebrates, chronic RQs are based on reproduction rate. The Environmental Incident Infor mation System (EIIS) database has records of two fish kills related to the use of endothall N, N - dimethylalkylamine salt. Accidental 19

### misuse of the biocide formulation in a Minnesota power plant cooling chamber resulted in the deaths of thousands of green sunfish, catfish, and shiners due to the high water temperature (92° C) at application. The second incident occurred when a 5 - gallon can of endothall N, N - dimethylalkylamine salt product spilled into a drain in California and resulted in the death of over one thousand carp. Terrestrial use of N,N - dimethylalkylamine salt also poses risks to aquatic organisms from runoff and drift. Acute LOCs are exceeded for freshwater fish (RQs range from 0.5 to 0.92), freshwater invertebrates (RQs range from 0.5 to 3. 23), and algae (RQs range from 1.04 to 7.65) from runoff. b. Risks from Use of Endothall Dipotassium Salt Endothall dipotassium salt is applied directly to the aquatic environment. The Agency used the acute toxicity values for endothall dipotassium salt to calculate risk to fish and aquatic invertebrates. On an acute basis, the dipotassium salt is considered to be slightly toxic to practically non - toxic to freshwater fish, slightlytoxic to estuarine/marine fish, and moderately toxic to practically non - toxic to estuarine/marine invertebrates. Aquatic non - endangered vascular plant LOCs are exceeded for acute exposure from all direct applications to water (RQs range from 2.5 to 8). Acute LOCs are exceeded for freshwater fish at maximum application rates (RQ = 0.55). Chronic risk was calculated for aquatic animals using endothall acid and endothall dipotassium salt toxicity data due to the dissociation of the dipotassium salt to endo thall acid. Chronic LOCs are minimally exceeded for freshwater fish from the highest application rate (RQ =1) and for freshwater invertebrates from the two highest application rates (RQs range from 1.1 to 1.4). Chronic RQs for freshwater fish are based o n wet weight and length, and chronic RQs for freshwater invertebrates are based on length and number of offspring. c. Risks from Endothall Acid Although endothall acid is not directly applied to use s ites, it is possible that plants and animals may be exposed to the acid. The dissociation constants of both of the salts indicate that at most environmental pH levels, the endothall salt, endothall acid, and the corresponding cation (potassium or coco - alk ylamine) will all be present. Endothall acid is considered to be slightly toxic to freshwater fish, slightly toxic to practically nontoxic to aquatic freshwater invertebrates, practically non - toxic to estuarine/marine fish, and slightly toxic to estuarin e/marine invertebrates on an acute basis. Chronic LOCs are minimally exceeded for freshwater fish from applications at the highest rate (RQ = 1), and for freshwater invertebrates from the two highest application rates (RQs range from 1.1 to 1.4). Chronic RQs for freshwater fish are based on wet weight and length, and chronic RQs for freshwater invertebrates are based on length and number of offspring.

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### 4. Risk to Endangered Species a.Risks fro m Use of Endothall N, N - dimethylalkylamine Salt As discussed previously, endothall N,N - dimethylalkylamine salt is used in both aquatic and terrestrial environments. For this reason, aquatic organisms are susceptible to exposure from aquatic applications, and both terrestrial and aquatic organisms are susceptible to exposure from terrestrial applications. Acute threatened and endangered species LOCs are exceeded in the screen ing level risk assessment for freshwater fish (RQs range from 12 to 119), estuarine/marine fish (RQs range from .6 to 6.10), freshwater invertebrates (RQs range from 6 to 417), estuarine/marine invertebrates (RQs range from 3.10 to 31.10), freshwater endan gered vascular plants (RQs range from 3 to 33), and freshwater algae (RQs range from 217 to 2174) from all direct applications to water, including once - through cooling tower uses. Chronic threatened and endangered LOCs are exceeded for freshwater fish (RQ s range from 2.2 to 22.2) and invertebrates (RQs range from 133 to 1331.3) from all direct applications to water, including once through cooling tower uses. From applications of endothall N, N - dimethylalkylamine salt made to terrestrial environments, b oth aquatic and terrestrial organisms are potentially exposed. Acute threatened and endangered LOCs are exceeded in the screening level risk assessment for freshwater fish (RQs range from 0.06 to 0.92), estuarine/marine fish (RQs =0.05), freshwater invert ebrates (RQs range from 0.05 to 3.23) and marine/estuarine invertebrates (RQs range from 0.05 to 0.24), and algae (RQs range from 1.04 to 7.65) from runoff. Acute threatened and endangered mammalian LOCs are also exceeded in the screening level risk asses sment for all terrestrial uses (based on endothall acid toxicity values) (RQs range from 0.10 to 9.74). Chronic threatened and endangered species LOCs are exceeded in the screening level risk assessment for mammals (RQs range from 1.04 to 3.03) and birds (RQs range from 1.02 to 9.10) from use on potatoes, hops, alfalfa, and clover. Threatened and endangered plants are potentially exposed to N, N dimethylalkylamine salt from drift and runoff from targeted application sites. Threatened and endangered sp ecies LOCs for non - target vascular plants are exceeded in the screening level risk assessment from adjacent runoff, wetland area runoff, and spray drift associated with use on all crops (RQs range from 1.5 to 137.5). Further, there may be potential for indirect effects to listed species in any taxa that are dependent upon a taxa that may experience effects from the use of this pesticide. The Agency feels that potential risks to terrestrial organisms from the N, N dimethylalkylamine salt may have been underestimated because RQs were based on toxicity data using endothall acid and endothall dipotassium salt. Available ecotoxicity studies using the N, N - dimethyalkylamine salt indicate it is more toxic to organisms than 21

### dipotassium salt or endothall acid . Additional data pertaining to the fate and ecotoxicity of the N, N - dimethylalkylamine salt is being requested. Risks to endangered species identified in the Environmental Fate and Ecological Risk Assessment for Endothall are based solely on EPA's screening level assessment and do not constitute "may effect" findings under the Endangered Species Act. b. Risks from Use of Endothall Dipotassium Salt Several threatened and endangere d species level of concern exceedences in the screening level risk assessment occur from use of endothall dipotassium salt. Exceedences occur for acute effects to freshwater fish (RQs range from 0.05 to 0.55) and vascular plants (RQs range from 181 to 108 7) from all direct applications to water. From applications at the highest rates (4 and 5 ppm), exceedences occur for marine/estuarine fish (RQs range from 0.05 to 0.06), freshwater invertebrates (RQs range from 0.06 to 0.08), and marine/estuarine inverte brates (RQs range from 0.06 to 0.07). Chronic RQs are minimally exceeded for freshwater fish (RQ = 1) and freshwater invertebrates (RQs range from 1.1 - 1.4) at maximum application rates. Data are unavailable with which to assess potential chronic risks to estuarine/marine species and therefore, potential risks can not be dismissed for these taxa. Further, there may be potential for indirect effects to listed species in any taxa that are dependent upon a taxa that may experience effects from the use of t his pesticide. These findings are based solely on EPA’s screening level assessment and do not constitute “may affect” findings under the Endangered Species Act. IV. Risk Management, Reregistration, and Tolerance Reassessment Decision A. Determination or Reregistration Eligibility Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission of relevant data concerning an active ingredient, whether or not products containing the active ingredient are eligible for reregistration. The Agency has previously identified and required the submission of the generic (i.e., active ingredient - specific) data required to support reregistration of products containing endothall as an active ingredient. The Agency has completed its review of these generic data, and has determined that the data are sufficient to support reregistration of allsupported products containing endothall. The Agency has completed its assessment of the dietary, occupational, drinking water, and ecological risks associated with the use of pesticide products containing the active ingredient endothall. Based on a rev iew of these data and on public comments on the Agency's assessments for the active ingredient endothall, the Agency has sufficient information on the human health and ecological effects of endothall to make decisions as part of the tolerance reassessment process under FFDCA and reregistration process under FIFRA, as amended by FQPA. The Agency has determined that endothall containing products are eligible for reregistration provided that (i) current data gaps and 22

### confirmatory data needs are addressed; (ii ) the risk mitigation measures outlined in this document are adopted; and (iii) label amendments are made to reflect these measures. Label changes are summarized in Section V. Appendix A summarizes the uses of endothall that are eligible for reregistrati on. Appendix B identifies generic data requirements that the Agency reviewed as part of its determination of reregistration eligibility of endothall, and lists the submitted studies the Agency found acceptable. Data gaps are identified as generic data re quirements that have not been satisfied with acceptable data or data which are needed to confirm the decision presented here. Based on its evaluation of endothall, the Agency has determined that endothall products, unless labeled and used as specified in this document, would present risks inconsistent with FIFRA. Accordingly, should a registrant fail to implement any of the risk mitigation measures identified in this document, the Agency may take regulatory action to address the risk concerns from the us e of endothall. If all changes outlined in this document are incorporated into the product labels, then all current risks for endothall will be adequately mitigated for the purposes of this determination under FIFRA. Additionally, once an endangered spec ies assessment is completed, further changes to these registrations may be necessary as explained in section IV.D.5.a of this document. B. Public Comments and Responses Through the Agency's public p articipation process, EPA worked with stakeholders and the public to reach the regulatory decisions for endothall. During the public comment period on the risk assessments, which closed on July 11, 2005, the Agency received comments from the registrant, t he United States Army Corps of Engineers, endothall applicators, and concerned citizens. These comments in their entirety are available in the public docket, http://docket.epa.gov/edkpub/index.jsp, OPP 2005 - 0370. The Agency's responses to these comments are incorporated into the revised chapters and are available in the public docket. C. Regulatory Position 1. Food Quality Protection Act Findings a. "Risk Cup" Determination As part of the FQPA tolerance reassessment process, EPA assessed the risks associated with endothall. The Agency has concluded that tolerances for endothall meet the FQPA safety standards and that the aggregate (food, drinking water, and residential sources) exposure is within the "risk cup". The Agency has determined that the human health risks from these combined exposures are within acceptable levels. In reaching this determination, EPA has considered the available information on the special sensitivity of infants and children. 23

### b. Determination of Safety to U.S. Population (Including Infants and Children) The Agency has determined that the established tolerances for endothall, with amendments and changes as specified in this document, meet the safety standards under the FQPA amendments to section 408(b) (2) (D) and 408 (b) (2) (c) of the FFDCA, and that there is a reasonable certainty that no harm will result to infants, children, or the general population or any subgroup from the use of endothall. The safety determination for infants and children considers factors incl uding toxicity, use practices, and environmental behavior noted above for the general population, but also takes into account the possibility of increased dietary exposure due to specific consumption patterns of infants and children, as well as the possibi lity of increased susceptibility to the toxic effects of endothall residues in this population subgroup. No special FQPA Safety Factor is necessary to protect the safety of infants and children. In determining whether or not infants and children are par ticularly susceptible to toxic effects from endothall residues, the Agency considered the completeness of the database for developmental and reproductive effects, the nature of the effects observed, and other information. The FQPA safety factor has been removed (i.e., reduced to 1X) for endothall based on: (1) there was no quantitative or qualitative evidence of increased susceptibility following prenatal exposure to rats in the developmental toxicity study or pre/postnatal exposure to rats in the 2 - generation rat toxicity study, (2) there are no concerns for residual uncertainty for prenatal toxicity in the available developmental study, or the 2 - generation rat toxicity study, and (3) there are no residual uncertainties for exposure. c. Endocrine Disru ptor Effects EPA is required under the FFDCA, as amended by FQPA, to develop a screening program to determine whether certain substances (including all pesticide active and other ingredients) "may have a n effect in humans that is similar to an effect produced by a naturally occurring estrogen, or other endocrine effects as the Administrator may designate." Following recommendations of its Endocrine Disruptor Screening and Testing Advisory Committee (EDST AC), EPA determined that there was a scientific basis for including, as part of the program, the androgen and thyroid hormone systems, in addition to the estrogen hormone system. EPA also adopted EDSTAC's recommendation that EPA include evaluations of potential effects in wildlife. For pesticides, EPA will use FIFRA and, to the extent that effects in wildlife may help determine whether a substance may have an effect in humans, FFDCA authority to require the wildlife evaluations. As the science develops a nd resources allow, screening for additional hormone systems may be added to the Endocrine Disruptor Screening Program (EDSP). When the appropriate screening and/or testing protocols being considered under the EDSP have been developed, endothall may be s ubject to additional screening and/or testing to better characterize effects related to endocrine disruption. 24

### d. Cumulative Risks Risks summarized in this document are those that result only from the use of end othall. The Food Quality Protection Act (FQPA) requires that the Agency consider "available information" concerning the cumulative effects of a particular pesticide's residues and "other substances that have a common mechanism of toxicity". The reason fo r consideration of other substances is due to the possibility that low- level exposures to multiple chemicals substances that cause a common toxic effect by a common toxic mechanism could lead to the same adverse health effect as would a higher level of exp osure to any of the substances individually. Unlike other pesticides for which EPA has followed a cumulative approach based on a common mechanism of toxicity, EPA has not made a common mechanism of toxicity finding for endothall. For information regar ding EPA's efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see the policy statements released by EPA's Office of Pesticide Programs concerning common mechanism determination s and procedures for cumulating effects from substances found to have a common mechanism on EPA's website at http://www.epa.gov/pesticides/cumulative. 2. Tolerance Summary A tolerance summary is presented belo w in Table 3. The Agency has determined that the residue of concern in plants, livestock, and fish is endothall and its monomethyl ester. The residue to be measured for tolerance enforcement is the combined residues of endothall and its monomethyl ester. Tolerances for residues of endothall, from use of the mono - N,N dimethyalkylamine salt, in/on plant commodities should be revised to be expressed in terms of endothall per se and its monomethyl ester [40 CFR § 180.293]. Tolerances that are currently established for residues in/ on undelinted cotton seed, hops, potato, and rice grain and straw will not change in value. An interim tolerance was established for residues of endothall in potable water; this tolerance will be proposed for revocation (an MCL is in effect for 100 μg/L). Under 40 CFR § 180.319 an interim tolerance exists for residues of endothall in/on sugar beets; this tolerance should be made permanent once additional data has been received and deemed acceptable. No tolerances have been establ ished for livestock commodities. The available ruminant and poultry metabolism studies suggest that detectable residues of endothall are likely to be transferred to meat, milk, poultry and eggs as a result of registered uses on feedstuffs. The registrant has been required to conduct animal (ruminant and poultry) feeding studies in meat, milk, poultry, and eggs in order to set appropriate tolerances. Data have been submitted to support tolerances in finfish, catfish, and shellfish. This action is not inc orporated into this document and will be addressed in a separate action. 25

### A gas chromatography method with microcoulometric nitrogen detection is listed as Method I in the Pesticide Analytical Manual (PAM, Volume II) for the determination of endothall residues in/on crop commodities. An improved high performance liquid chromotography- mass selective detector (HPLC - MSD) method has been submitted as a confirmatory enforcement method for plants and fish. Data collection and regulatory analytical methods for animal commodities are currently not available and are required for reregistration. The submitted magnitude of the residue studies for alfalfa seed, cottonseed, and potatoes have been reviewed and were deemed inadequate to satisfy reregistration requirements. The submitted data for hops supports the national Section 3 labels, but does not support the Section 24(c) Special Local Need uses because a different pre harvest interval was used. The submitted residue data for irrigated cabbage, celery, grap efruit, pepper, and turnip have been deemed inadequate because the water treatment rate was less than the maximum label rate. The submitted confined rotational crop study was deemed inadequate because the test substance was applied at a rate less than the maximum registered seasonal rate for crops which can be rotated. The submitted processing studies on cotton and potatoes are acceptable, and the results of these studies show that endothall does not concentrate in the processed fractions of cotton and p otatoes. A sugar beet processing study was submitted and was deemed inadequate. Although additional data are required to confirm the existing tolerance level in/on the following commodities, the Agency has no dietary, drinking water or residential risk concerns associated with these tolerances and considers them reassessed: cotton (undelinted seed), hop, potato, rice (grain), rice (straw), and sugar beet. Endothall is registered for use on aquatic areas such as irrigation and drainage canals, and the treated water from these sites may be diverted to irrigate food or feed crops. The Agency requested the registrant to submit studies to address residues on irrigated crops. In response, the registrant submitted limited studies that investigated the magni tude of endothall residues on irrigated crops such as cabbage, celery, grapefruit, peppers, and turnips. These studies were not conducted using maximum labeled application rates or label - specified application intervals. Additional data on irrigated crops are required for reregistration. For the purpose of continuity, the Agency is requiring that the submitted studies be redone using current label instructions.

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### a. Tolerances Currently Listed and Tolerance Reassessment Table 6. Tolerance Table Commodity Current Reassessed Comments Tolerance Tolerance

(ppm) (ppm) Tolerances Listed Under 40 CFR § 180.293 (a)(1) Cotton, 0.1 To Be Additi onal data are required. Data submitted Undelinted Seed Determined (TBD) by the registrant was performed in the wrong geographic area, used incorrect rates, the wrong pre -harvest interval, and the cotton was delinted prior to analysis. Hop 0.1 TBD Additional data are required. Submitteddata does not support 24(c) registrations. Change commodity name to Hop, Dried Cones Potato 0.1 TBD Additional data are required. Data submitted by the registrant used incorrect application rate. Rice, Grain 0.05 (N) TBD Although there are presently no registered uses on rice, the Agency recommends the retention of these tolerances until the Rice, Straw 0.05 (N) TBD registrant has submitted the requested irrigation crop data that should include data for rice commodities. Tolerance Listed Under 4 0 CFR § 180.293 (a)(2) Potable Water 0.2 Revoke Tolerance EPA's Office of Pesticide Programs no longer establishes tolerances in drinking water. EPA's Office of Water has established an MCL for endothall at 0.1 ppm Tolerance Listed Under 40 CFR § 180.31 9 Beet, Sugar 0.2 TBD Additional data are required. Although there are presently no registered uses on sugar beets, the Agency recommends the retention of the interim tolerance until the registrant has submitted the requested irrigation crop data. Resid ue data must include data for both sugar beet root and tops. Change commodity name to Beet, sugar, root. Tolerances to be Proposed Under 40 CFR § 180.293 Cotton Gin NA TBD A tolerance for cotton gin byproducts will Byproducts need to be proposed when re questing cotton field trials and have been received and evaluated. Animal NA TBD Tolerances for animal commodities will need Commodities to be proposed when the requested cotton field trials have been received and evaluated. Processed Commodities NA TBD Tolerances for processed commodities may be needed if the levels of endothall residues expected in processed commodities are found to be significantly higher than the raw agricultural commodities. 

### 27Commodity Current Reassessed Comments Tolerance Tolerance

(ppm) (ppm) Fish and Shellfish NA TBD Tolerances that have been propo sed for fish and shellfish may become acceptable after the appropriate stability data and independently validated enforcement method have been submitted. NOTE: The Agency has no dietary, drinking water, or residential risk concerns associated with these tolerances and consider them reassessed at the current tolerance level. The "TBD" designation is used, however, to convey that the Agency expects that the data required in the DCI that will be issued as a result of this RED will confirm that conclusion. 

### D. Regulatory Rationale The Agency has determined that endothall is eligible for reregistration provided that additional required data are sub mitted to confirm this decision that the risk mitigation measures outlined in this document are adopted, and label amendments are made to reflect these measures. This decision considers the risk assessments conducted by the Agency and the significance of the use of endothall. The following is a summary of the rational e for managing risks associated with the use of endothall. Where labeling revisions are warranted, specific language is set forth in the summary tables in Section V of this document. 1. Human Health Risk Management a. Dietary Risk Mitigation (food and drinking water) As discussed in sections III.A.4 and 5, chronic dietary risks (food and drinking water) do not exceed the Agency's level of concern, although drinking water ris k for infants less than one year old is at the level of concern. The Agency believes that this risk estimate is the result of conservative assumptions used in the risk assessment. However, to ensure that dietary (food and drinking water) risks are below the Agency's level of concern, drinking water intake setbacks will be added to endothall labels for aquatic uses. The following language will be added to aquatic use labels: "Drinking Water (Potable Water) � Consult with appropriate state or local water au thorities before applying this product to public waters. State or local agencies may require permits. The drinking water (potable water) restrictions on this label are to ensure that consumption of water by the public is allowed only when the concentrati on of endothall is the water is less than the MCL (Maximum Contaminant Level) of 0.1 ppm. Applicators should consider the unique characteristics of the treated waters to assure that endothall concentrations in potable drinking water do not exceed 0.1 ppm at the time of consumption.

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### � For applications of endothall, the drinking water setback distance from functioning potable water intakes is greater than or equal to 600 feet. � Note: Existing potable water intakes that are no longer in use, such as those repl aced by a connection to a municipal water system or a potable water well, are not considered to be functioning potable water intakes. � Drinking water setbacks distances do not apply to terrestrial applications of endothall adjacent to water bodies with p otable water intakes." b. Occupational Risk Mitigation As discussed in Section III.A.8.a, most occupational exposure scenarios are below the Agenc y's level of concern. However, some mitigation is required to protect workers in scenarios the Agency has indicated might result in a risk to workers. To protect workers mixing and loading liquid formulations for aerial applications to terrestrial sites , workers are required to wear an 80% (PF5) respirator (NIOSH TC - 21C). To protect workers mixing, loading, and applying liquid formulations for aquatic applications, workers must wear an 80% (PF5) respirator (NIOSH TC - 21C). To protect workers loading and applying granular formulations for aquatic uses, workers are required to wear a 90% (PF10 eslastomeric half face respirator with appropriate cartridge) respirator (NIOSH TC - 23C or NIOSH TC - 14G). Specific label language will include: � During granular appl ications, the respirator need not be worn, provided that the pesticide is applied in a manner (such as aerial application or subsurface release or from the rear of a vessel that is moving into the wind) that the applicator will have no contact with the pes ticide. � During liquid applications, the respirator need not be worn, provided that the pesticide is applied in a manner (such as direct metering or subsurface release from the rear of a vessel that is moving into the wind) that the applicator will have n

o contact with the pesticide. The Agency has determined that endothall is a severe dermal irritant. Label requirements addressing dermal effects will be addressed when toxicity data is submitted for end - use products. The Agency will require personal protective equipment based on end - use product toxicity during product reregistration. To protect workers from exposures during post - application activities, the re - entry interval of 48 hours will remain for agricultural workers (terrestrial applications). Because endothall is a severe skin irritant, the Agency is requiring that double notification statements be added to labels intended for terrestrial use. c. Residential Risk Mitigation Although the A gency did not identify any residential use scenarios that resulted in risk concerns, the following statement will be put on labels addressing residential uses: 29

### "Consult local and state fish and game agency and water control authorities before applying th is product. Permits may be required to treat such water." 2. Environmental Risk Management To address risks to aquatic organisms, additional directions for use and use restrictions will be added toproduct labels to reduce potential risks. Specific language and restrictions are different for the dipotassium salt and the N, N - dimethylalkylamine salt, and are discussed below. a. Dipotassium Salt The Agen cy is requiring that labels for the dipotassium salt form of endothall specify different rates for different size applications. This language will specify that for large treatment areas, lower rates of endothall dipotassium salt must be used. For smaller , spot treatments, higher rates of endothall dipotassium salt can be used. For example, to treat infestations of Coontail, large areas can be treated with rates of 1 - 2 ppm and small areas can be treated using higher rates (2 - 3 ppm). Specific language will include: "Only use higher rates (see above example) when making treatments to small areas with an increased potential for rapid dilution or when making long and narrow applications such as for boat lanes or shoreline treatments where dilution may reducethe exposure of plants and the herbicide." "Use the lower rates (see above example) for large contiguous treatment blocks, or in protected areas such as coves where reduced water movement will not result in rapid dilution of the herbicide from the targe t treatment area or when treating entire lakes or ponds." b. N, N - dimethylalkylamine Salt The Agency is requiring that products used in lakes, ponds, streams, and other bodies of water are limited to applications to control algae, Hygrophila, Vallisneria, Hydrilla, Cabomba, bur weed, Elodea canadensis and Brazilian elodea . The following plants are to be removed from endothall N, N - dimethylalkylamine labels: Coontail, Milfoil, Naiad (Najasspp.), Po ndweed (Potamogeton spp.), Water Stargrass, and Zannichellia. 3. Significance of Endothall Use Endothall is an important part of aquatic weed and algae management. Currently there are not many aqua tic herbicide alternatives available. Although endothall potentially poses risks to non - target plants and aquatic organisms, typical use patterns 30

### and additional label requirements required in this RED will reduce exposure to non - target organisms while mai ntaining its most important uses. The N, N - dimethylalkylamine salt is an important tool for controlling algae and aquatic weeds that cannot be controlled with endothall dipotassium salt. Typical rates used to control algae are low (0.05 - 0.3 ppm). In addition, RQs were calculated using a range of rates from 0.5 to 5 ppm. Therefore, RQs that were calculated using the lowest rate of 0.5 ppm potentially overestimates risk. When algae are dense, and a higher rate is needed, labels require that application areas are limited to no more than 10% of the water body. Further, when algae are dense, oxygen levels in the water are low. When conditions such as this exist, fish generally are not present and will not likely be exposed to high application rates. In addition, as required mitigation in this RED, the N, N dimethylalkylamine salt will only be used on a select set of vascular plants (Hygrophila, Vallisneria, H ydrilla, Cabomba, bur weed, Elodea Canadensis and Brazilian elodea). Previous labels allowed use o n Coontail, Milfoil, Naiad (Najasspp.), Pondweed (Potamogeton spp.), Water Stargrass, and Zannichellia. Current labels warn of toxicity to fish and aquatic organisms and do not recommend applications above 0.3ppm where fish are important resources. Anot her important aspect of N, N - dimethylalkylamine salt use is that commercial applicators are required to apply rates above 0.3 ppm and must get the appropriate state permitting to make an application. Endothall dipotassium salt is an important part of aquatic weed management and controlling submerged aquatic vegetation. Although use of endothall dipotassium salt poses risks to non - target plants and aquatic organisms, typical use patterns will minimize exposure to non - target organisms. For example, high er rates of the dipotassium salt are used only for spot treatments in small areas where dense weeds are problematic. Large areas that require weed control with the dipotassium salt are treated with lower rates and entire bodies of water are not typically treated at one time. Similar to the N, N dimethylalkylamine salt, proper permitting and approval is required. In addition to the importance of aquatic uses of endothall, the terrestrial use of N, N - dimethylalkylamine salt is an important desiccant. The terrestrial use of N, N dimethylalkylamine salt is minimal. Applications of endothall as a desiccant are reserved for sites where use of other desiccants poses risks to adjacent fields. Additionally, terrestrial application rates of endothall N, N - dimet hylalkylamine salt are very low. Together, the minimal use and low application rates minimize risks to terrestrial organisms. 4. Other Labeling Requirements In order to be eligible for reregistratio n, endothall use and safety information will be included in the labeling of all end - use products containing endothall. For the specific labeling statements and a list of outstanding data, refer to Section V of this RED document.

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### 5.Threatened and Enda ngered Species Considerations a. The Endangered Species Program The Agency has developed the Endangered Species Protection Program to identify pesticides whose use may cause adverse impacts on threatened and endangered species, and to implement mitigation measures that address these impacts. The Endangered Species Act requires federal agencies to ensure that their actions are not likely to jeopardize listed species or adversely modify designated critical habitat. To analyze the potential of registered pesticide uses that may affect any particular species, EPA uses basic toxicity and exposure data developed for the REDs and the n considers ecological parameters, pesticide use information, geographic relationship between specific pesticide uses and species locations, and biological requirements and behavioral aspects of the particular species. When conducted, this species - specifi c analysis will also consider the risk mitigation measures that are being implemented as a result of this RED. Following this future species - specific analysis, a determination that there is a likelihood of potential effects to a listed species may result in limitations on use of the pesticide, other measures to mitigate any potential effects, or consultations with the Fish and Wildlife Service and/or the National Marine Fisheries as appropriate. If the Agency determines use of endothall "may effect" listed species or their designated critical habitat, EPA will employ the provisions in the Services regulations (50 CFR Part 402). Until a species specific analysis is completed, the risk mitigation measures being implemented through this RED will reduce the likelihood that endangered and threatened species may be exposed to endothall at levels of concern. EPA is not requiring specific endothall label language at the present time relative to threatened and endangered species. If, in the future, specific meas ures are necessary for the protection of listed species, the Agency will implement them through the Endangered Species Program. b. General Risk Mitigation Endothall end - use products (EUPs) may also conta in other registered pesticides. Although the Agency is not proposing any mitigation measures for products containing endothall specific to federally listed threatened and endangered species, the Agency needs to address potential risks from other end - use products. Therefore, the Agency requires that users adopt all threatened and endangered species risk mitigation measures for all active ingredients in the product. If a product contains multiple active ingredients with conflicting threatened and endangere d species risk mitigation measures, the more stringent measure(s) must be adopted.

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### V. What Registrants Need to Do The Agency has determined that endothall is eligible for reregistration provided t hat: (i) additional data that the Agency intends to require to confirm this decision; (ii) the risk mitigation measures outlined in this document are adopted; and (iii) label amendments are made to reflect these measures. To implement the risk mitigation measures, the registrants must amend their product labeling to incorporate the label statements set forth in the Label Changes Summary Table in Section B below (Table 6). The additional data requirements that the Agency intends to obtain will include, amo ng other things, submission of the following: For endothall technical grade active ingredient products, the registrant needs to submit the following items: Within 90 days from the receipt of the generic data call in (DCI): 1. Completed response forms to the generic DCI (i.e., DCI response form and requirement status and registrant's response form); and 2. Submit any time extension and/or waiver requests with a full written justification. Within the time limit specified in the generic DCI: 1. Cite any existing generic data which address data requirements or submit new generic data responding to the DCI. Please contact Anne Overstreet at (703) 308 - 8068 with questions regarding generic registration. By US Mail: By express or courier service: Document Processing Desk (DCI/SRRD) Document Processing Desk (DCI/SRRD) An ne Overstreet Anne Overstreet US EPA (7508C) Office of Pesticide Programs (7508C) 1200 Pennsylvania Ave., NW Room 266A, Crystal Mall 2 Washington, DC 20460 1801 S. Bell Street Arlington, V A 22202 For end - use products containing the active ingredient endothall, the registrant needs to submit the following items for each product: Within 90 days from the receipt of the product - specific data call - in (PDCI):

33

### 1. Completed response forms to the PDCI (i.e., PDCI response form and requirement status and registrant's response form); and 2. Submit any time extensions and/or waiver requests with a full written justification. Within eight months from the receipt of the PDCI: 1. Two copies o f the confidential statement of formula (EPA Form 8570 - 4); 2. A completed original application for reregistration (EPA Form 8570 - 1). Indicate on the form that it is an "application for reregistration"; 3. Five copies of the draft labeling incorporatin g all the label amendments outlined in Table 7 of this document; 4. A completed form certifying compliance with data compensation requirements (EPA Form 8570 - 34); 5. If applicable, a completed form certifying compliance with cost share offer requiremen ts (EPA Form 8570 - 32); and 6. The product - specific data responding to the PDCI. Please contact Venus Eagle at (703) 308 - 8045 with questions regarding product reregistration and/or the PDCI. All materials in response to the PDCI should be addressed as follows: By US Mail: Document Processing Desk (PDCI/SRRD/PRB) Venus Eagle US EPA (7508C) 1200 Pennsylvania Ave., NW Washington, DC 20460 By express or courier service: Document Processing Desk (PDCI/SRRD/PRB) Venus Eagle Office of Pesticide Programs (7 508C) Room 266A, Crystal Mall 2 1801 S. Bell Street Arlington, VA 22202 A. Manufacturing Use Products 1. Additional Generic Data Requirements The generic database supporting the reregistration of endothall has been reviewed and determined to be substantially complete. However, the following additional data 34

### requirements have been identified by the Agency as confirmatory and are included i n the generic DCI for this RED. Table 7. Confirmatory Data Requirements for Reregistration Guideline Number Study/Requirements 71 - 4 Avian Chronic Reproduction study in quail or duck using N,N - dimethylalkylamine (850.2300) salt 72 - 4C (850.1400) Estuarin e/Marine Fish Early Life - Stage Study using N,N - dimethylalkylamine salt 72 - 4B Estuarine/Marine Invertebrate Early Life - Stage study using N,N - (850.1350) dimethylalkylamine salt 72 - 5 (850.1500) Fish Life - Cycle study using N,N - dimethylalkylamine salt 850.17 35 Acute Freshwater Sediment study using N,N - dimethylalkylamine salt 850.1740 Acute Estuarine/Marine Sediment study using N,N - dimethylalkylamine salt Special Study Chronic Estuarine/Marine Sediment Testing using N,N - dimethylalkylamine salt Special Study 65 - day Test in Chironomus tentans using N,N - dimethylalkylamine salt 83 - 3B (870.3700B) Developmental/Teratology in Non - rodent (rabbit) study 82 - 4 (870.3465) 28 - day Inhalation study 171 - 4C & D (860.1340) Residue Analytical Method - Plants and Animals. Radi ovalidation data needed to determine whether the current enforcement methods for plants and the required enforcement method(s) for animals can adequately extract and convert aged residues of the monomethyl ester to endothall. 171 - 4D Data collec tion and regulatory analytical methods are needed for the determination (860.1340) of endothall, per se, in animal commodities 171 - 4 Submission of analytical reference standards for dipotassium and mono - N,N- (860.1340) dimethylalkylamine salts of endothall 171 - 4E Storage stability data for processed plant commodities, animal commodities, and (8 60.1380) fish 171 - 4J (860.1480) Livestock (ruminant and poultry) feeding studies 171 - 4H (860.1400) Magnitude of residues in irrigated crops 171 - 4L (860.1520) Magnitude of re sidue studies in potato, alfalfa seed, cotton seed, and cotton gin products. Magnitude of residue studies in raw agricultural commodities of sugar beet and rice if the registrant is supporting these uses 171 - 4L Processing studies on apples, fi eld corn, grapes, orange, rice, sorghum, soybeans, (860.1520) sugar beet, tomato, and wheat to cover irrigation uses 165 - 1 A confined, rotational crop study after treatment at the proper maximum labeled (860.1850) rate for irrigation water 

### 2. Labeling for Techn ical and Manufacturing Use Products To ensure compliance with FIFRA, technical and manufacturing use products (MP) labeling should be revised to comply with all current EPA regu lations, PR Notices and applicable policies. The technical and MP labeling should bear the labeling contained in Tables 8 and 9, Label Changes Summary Table. 35

### B. End- Use products 1. Additional Product - Specific Data Requirements Section 4(g) (2) (B) of FIFRA calls for the Agency to obtain any needed productspecific data regarding the pesticides after a determination of eligibility has been ma de. The registrant must review previous data submissions to ensure they meet current EPA acceptance criteria and if not, commit to conduct new studies. If a registrant believes that previously submitted data meet current testing standards, then the study MRID numbers should be cited according to the instructions in the Requirement Status and Registrations Response Form provided for each product. A product- specific data call - in, outlining specific data requirements, accompanies this RED. 2. Labeling fo r End - Use Products Labeling changes are necessary to implement measures outlined in Section IV above. Specific language to incorporate these changes is specified in the Label Changes Summary Table bel ow. Existing stocks time frames will be established case by case, depending on the number of products involved, the number of label changes, and other factors. Refer to "Existing Stocks of Pesticide Products; Statement of Policy," Federal Register, Volu me 56, No. 123, June 26, 1991. a. Label Changes Summary Table In order to be eligible for reregistration, amend all product labels to incorporate the risk mitigation measures outlined in Section IV. The following table describes how language on the labels should be amended.

36

### Table 8. Summary of Required Labeling Changes for Products Registered for Aquatic Uses Only of Endothall Description Required Labeling Language Placement on Label Manufactur ing - Use Products Required on all Manufacturing "Only for formulation into an herbicide for the following use(s) [fill blank only with those Directions for Use Use Products uses that are being supported by the MP registrants]." One of these statements may be A This product may be used to formulate products for specific use(s) not listed on the MP Directions for Use added to allow reformulation of label if the formulator, user group, or grower has complied with U.S. EPA submission the product for a specific use or requirements regarding support of such use(s). @ all additional uses supported by a formulator or user group. A This product may be used to formulate products for any additional use(s) not listed on the MP label if the formulator, user group, or grower has complied wit h U.S. EPA submission requirements regarding support of such use(s). @ Environmental Hazards A This pesticide is toxic to fish and aquatic invertebrates. Do not discharge effluent Directions for Use Statements Required by the RED and Agency Label Policies containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless in accordance with the requirements of a National Pollutant Discharge Eliminations System (NPDES) permit and the permitting authority has been notified in writin g prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance, contact your State Water Board or Regional Office of the Environmental Protection Agency. @ End - Use Products Intended of Occupational Use Note the following information when preparing labeling for all end -use products: For sole - active - ingredientend -use products that contain endothall, the product label must be revised to adopt the handler personal protective equipment (PPE)/engineering control requirements set forth in this section. Any conflicting PPE requirements on the current label must be removed. For multi - active - ingredientend -use products that contai n endothall, the handler PPE/engineering control requirements set forth in this section must be compared with the requirements on the current label, and the more protective language must be retained. For guidance on which requirements are considered to be more protective, see PR Notice 93 - 7. PPE that is established on the basis of Acute Toxicity testing with end -use products must be compared with the active ingredient PPE specified below in this document. The more protective PPE must be placed in the pro duct labeling. For example, the Handler PPE in this RED does not require protective eyewear which may be required by the Acute Toxicity 

### 37Description Required Labeling Language Placement on Label testing for the end -use product. For guidance on which PPE is considered more protective, see PE Notice 93 - 7. Handl er PPE Requirements for Liquid Formulations for Aquatic Applications "Mixers, loaders, applicators, and other handlers must wear:

- long - sleeve shirt,

- long pants, Precautionary Statements: Hazards to Humans and Domestic Animals

- shoes and socks, and

- a NIOSH - approved respirator with a dust/mist filter with MSHNA/NIOSH approval number prefix TC- 21C or any N, R, P, or He filter. Exception: during application, the respirator need not be worn, provided that the pesticide is applied in a manner (such as direct metering or subsurface release from the rear of a vessel that is moving into the wind) that the applicator will have no contact with the pesticide. See engineering controls for additional options." Handler PPE Requirements for Granular Formulations for Aquatic Applications "Mixers, loaders, applicators, and other handlers must wear:

- long - sleeve shirt,

- long pants,

- shoes and socks, and

- a NIOSH - approved half-or full - face respirator with a cartridge approved for dusts and mists or a canister approvedfor dusts and mists or a cartridge with any N*, R, P, or He filter. Note: the quarter - face cup - style respirator does not meet this requirement. Exception: during application, the respirator need not be worn, provided that the pesticide is applied in a man ner (such as aerial application or subsurface release or from the rear of a vessel that is moving into the wind) that the applicator will have no contact with the pesticide. See optional engineering controls for additional instructions." *Instruction to registrant: Drop the "N" type pre - filter from the response statement if the pesticide product contains, or is used with, oil. Engineering Controls: Liquid Engineering Control Statement for Optional Use (WPS only) Precautionary Statements: Formulations Only Hazards to Humans and "Engineering Controls: Domest ic Animals (Immediately following PPE 

### 38Description Required Labeling Language Placement on Label "When mixers and loaders use a closed system designed by the manufacturer to enclose the and User Safety Requirements) pesticide to prevent it from contacting handlers or other people AND the system is functioning properly and is used and maintained in accordance with the manufactu rers written operating instructions, the handlers need not wear a respirator, provided the required respirator is immediately available for use in an emergency such as a spill or equipment breakdown." Engineering Controls: Enclosed "Engineering Controls: Precautionary Statements: Cockpit for Granular Aerial Hazards to Humans and Applicators Pilots must used an enclosed cockpit that meets the requirements listed in the WPS for Domestic Animals agric ultural pesticides [40 CFR 170.240(d) (6)." (Immediately following PPE and User Safety Requirements) User Safety Requirements A Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions Precautionary Statements: for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry. @ Hazards to Humans and Domestic Animals (Immediately following PPE A Discard clothing or other absorbent materials that have been drenched or heavily contaminated with this product = s concentrate. Do not reuse them. @ and User Safety Requirements) User Safety Recommendations A USER SAFETY RECOMMENDATIONS @ Precautionary Statements under: Hazards to Humans and A Users should wash hands before eating, drinking, c hewing gum, using tobacco, or using the toilet. @ Domestic Animals immediately following Engineering Controls A Users should remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. @ (Must be placed in a box.) A Users should remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. @ Environmental Hazards "ENVIRONMENTAL HAZARDS" Precautionary Statements under Environmental Hazards "This pesticide is toxic to fish. This pesticide is toxic to wildlife. " "Do not contaminate water by cleaning of equipment or disposal of equipment wash waters. Do not contaminate water, food, or feed by storage or disp osal." 

### 39Description Required Labeling Language Placement on Label Applications Restrictions for all "Do not apply this product in a way that will contact workers or other persons, either Directions for Us e directly products applied as a spray directly or through drift." above the Agricultural Use Box Application Restrictions for "Aerial application is prohibited." Directions for Use (near the Aquatic Applications - Liquids beginning of the section) Formulations Only Other Use/Application Restrictions Streams, R ivers, Channeled Water: Do not contaminate water intended for irrigation or domestic purposes. Do not use water for spraying or irrigation within 7 days after treatment. Directions for Use under General Precau tions and Restrictions and/or Application Instructions Swamps, Marshland, Wetlands, Stagnant Water:Do not contaminate water intended for i rrigation or domestic purposes. Human Drinking Water Systems: Do not contaminate water intended for irrigation or domestic purposes. Commercial, Industrial Water Cooling Systems: Do not discharge the effluent containing this pesticide into sewage sys tems without notifying the sewage treatment plant authority (POTW). Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or public water (NPDES license restrictions). Other Use/Application Restrictions Drinking Water (Potable Water) � Consult with appropriate state or local water authorities before applying this product to public waters. State or local agencies may require permits. The drinking water (potable water) restrictions on this label are to ensure that consumption of water by the public is allowed only when the concentration of endothall is the water is less than the MCL (Maximum Contaminant Level) of 0.1 p pm. Applicators should consider the unique characteristics of the treated waters to assure that endothall concentrations in potable drinking water do not exceed 0.1 ppm at the time of consumption. Directions for Use under General Precautions and Restrictions and/or Application Instructions

� For applications of endothall, the drinking water setback distance from functioning potable water intakes is greater than or equal to 600 feet. � Note: Existing potable water intakes that are no longer in use, such as those 

### 40Description Required Labeling Language Placement on Label replaced by a connection to a municipal water system or a potable water well, are not cons idered to be functioning potable water intakes. � Drinking water setbacks distances do not apply to terrestrial applications of endothall adjacent to water bodies with potable water intakes." Additional Use/Application Restrictions for Endothall Dipotassium Salt "Only use higher rates when making treatments to small areas with an increased potential for rapid dilution or when making long and narrow applications s uch as for boat lanes or shoreline treatments where dilution may reduce the exposure of plants and the herbicide." "Use lower rates for large contiguous treatment blocks or in protected areas such as coves where reduced water movement will not result in rapid dilution of the herbicide from the target treatment area or when treating entire lakes or ponds." Additional Use/Application Restrictions for Endothall N, N Dimethylalkylamine Salt All Water bodies (except Irrigation Canals/Ditches): Use of endoth all N, N dimethylalkylamine salt is limited to algae and the following plants: Hygrophila, Vallisneria, Hydrilla, Cabomba, bur weed, Elodea canadensis, and Brazilian e lodea . Lakes, Ponds, Reservoirs (with human or wildlife use): Do not contaminate water intended for irrigation or domestic purposes. Do not use water for domestic purposes until 25 days after treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use treated water for animal consumption within 25 days of treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use treated water for spraying or irrigation within 25 days of treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. D o not use where fish are important resources. Do not treat more than 10% of the area at one time with doses in excess of 1 ppm . Agricultural Drainage Systems, Drainage Systems:Do not use water for domestic purposes until 25 days after treatment of 5 ppm , 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use treated water for animal consumption within 25 days of treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use treated water for spraying or irrigation within 25 days of treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use where fish are important resources. Do not treat more than 10% of the area at one time with doses in excess of 1 ppm. 

### 41

### Table 9. Summary of Required Labeling Changes for Products Registered for Terrestrial Uses Only of Endothall Description Required Labeling Language Placement on Label Manufacturing - Use Products Required on all Manufacturing "Only for formulation into an herbicide for the following use(s) [fill blank only with those Directions for Use Use Products uses that are being supported by the MP registrants]." One of these statements may be A This product may be used to formulate products for specific use(s) not listed on the MP Directions for Use added to allow reformulation of label if the formulator, user group, or grower has complied with U.S. EPA submission the product for a specific use or requirements regarding support of such use(s). @ a ll additional uses supported by a formulator or user group. A This product may be used to formulate products for any additional use(s) not listed on the MP label if the formulator, user group, or grower has complied with U.S. EPA submission requirements regarding support of such use(s). @ Environmental Hazards A This pesticide is toxic to fish and aquatic invertebrates. Do not discharge effluent Directions for Use Statements Required by the RED and Agency Label Policies containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless in accordance with the requirements of a National Pollutant Discharge Eliminations System (NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this produc t to sewer systems without previously notifying the local sewage treatment plant authority. For guidance, contact your State Water Board or Regional Office of the Environmental Protection Agency. @ End - Use Products Intended of Occupatio nal Use Note the following information when preparing labeling for all end -use products: For sole - active - ingredientend -use products that contain endothall, the product label must be revised to adopt the handler personal protective equipment (PPE)/engin eering control requirements set forth in this section. Any conflicting PPE requirements on the current label must be removed. For multi - active - ingredientend -use products that contain endothall, the handler PPE/engineering control requirements set forthin this section must be compared with the requirements on the current label, and the more protective language must be retained. For guidance on which requirements are considered to be more protective, see PR Notice 93 - 7. PPE that is established on the b asis of Acute Toxicity testing with end -use products must be compared with the active ingredient PPE specified below in this document. The more protective PPE must be placed in the product labeling. For example, the Handler PPE in this RED does not requi re protective eyewear which may be required by the Acute Toxicity 

### 42Description Required Labeling Language Placement on Label testing for the end -use product. For guidance on which PPE is considered more protective, see PE Notice 93 - 7. Handler PPE Requirements "Mixers, loaders, applicators, and other handlers must wear:

- long - sleeve shirt,

- long pants,

- shoes and socks." "In addition, mixers and loaders supporting aerial applications must wear:

- NIOSH - approved respirator with a dust/mist filter with MSHNA/NIOSH approval number prefix TC- 21C or any N*, R, P, or He filter." *Instruction to registrant: drop the "N" type pre - filter from the respirator statement if the pesticide product contains, or is used with, oil. "See engineering controls for additional requirements." Precautionary Statements: Hazards to Hu mans and Domestic Animals

Engineering Controls "Engineering Controls: Pilots must use an enclosed cockpit that meets the requirements listed in the WPS for agricultural pesticides [40 CFR 170.240(d)(6). Human flagging is prohibited. Flagging to support aerial applications is limited to use of the Global Positioning System (GPS) or mechanical flaggers. When handlers use closed systems, enclosed cabs, or cockpits in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for a gricultural pesticides (40 CFR 170.240(d)(4- 6), the handler PPE requirements may be reduced or modified as specified in the WPS." Precautionary Statements: Hazards to Humans and Domestic Animals (Immediately following PPE and User Safety Requirements)

U ser Safety Requirements A Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry. @ A Discard clothing or other absorbent ma terials that have been drenched or heavily Precautionary Statements: Hazards to Humans and Domestic Animals (Immediately following PPE and User Safety Requirements) 

### 43Description Required Labeling Language Placement on Label contaminated with this product = s concentrate. Do not reuse them. @ User Safety Recommendations A USER SAFETY RECOMMENDATIONS @ Precautionary Statements under: Hazards to Humans and A Users should wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. @ Domestic Animals immediately following Engineering Controls A Users should remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothin g. @ (Must be placed in a box.) A Users should remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. @ Environmental Hazards "ENVIRONMENTAL HAZARDS" Precautionary Statements under Environmental Hazards "Do not apply directly to water, or to areas where water is present to intertidal areas below the mean high water mark. This pesticide is toxic to fish. This pesticide is toxic to wildlife. Keep out of lakes, streams, and ponds." Applications Restrictions for all "Do not apply this product in a way that w ill contact workers or other persons, either Directions for Use directly products applied as a spray directly or through drift." above the Agricultural Use Box Restricted - Entry Interval for "Do not ender or allow worker entry into treated areas during the restricted entry interval Directions for Use, Agricultural WPS products as required by (REI) of 48 hours." Use Requirements Box Supplement Three of PR Notice 93 - 7 Early Re - Entry Personal "PPE required for early entry to treated areas that is permitted under the WPS and that Directions for Use, Agricultural Protective Equipment for involves contact with anything that has been treated, such as soil or water, is: Use Requirements Box Products subject to WPS as required by Supplement Three - coveralls over long sleeved shirt and long pants, of PR Notice 93 - 7 - chemical -resistant gloves mad e of any waterproof material,

- chemical -resistant footwear plus socks,

-protective eyewear, and

-headgear for overhead exposure. Double Notification Statement "Notify workers of the application by wa rning them orally and by posting warning signs at Agricultural Use Requirements, entrances to treated area" following Early Entry PPE and REI statements Other Use/Application "Treated crops must be harvested by mechanical means only. Do not contaminate water by Directions for Use Associated Restrictions cleaning of equipment or disposal of equipment wash waters. Do not contaminate water, with Each Crop 

### 44Description Required Labeling Language Placement on Label food, or feed by storage or disposal. Do not apply through any type of irrigation system. Do not apply where drift is likely to occur. Alfalfa an d Clover: Do not feed treated fodder and/or forage to animals being finished for slaughter. Do not graze treated areas. Do not use seed for food, feed, or oil purposes. Grown for seed only. Hops:Do not feed treated fodder and/or forage to animals bein g finished for slaughter. 85 ­ day Pre - Harvest Interval (PHI) Potato: Do not feed treated forage to animals being finished for slaughter. Do not graze treated areas. 14 - day PHI. Cotton:7 - day PHI. Spray Drif t Label Language for RELEASE HEIGHT: Directions for Use under Products Applied as a Spray "Apply using a nozzle height of no more than 4 feet above the ground or canopy cover." General Precautions and through Ground Equipment Restrictions Spray Drift Labe l Language for Products Applied as a Spray through Airblast Equipment "Sprays must be directed into the crop canopy." "Outward pointing nozzles should be turned off at row ends and when spraying outer rows." Directions for Use under General Precautions and Restrictions TEMPERATURE INVERSIONS: "If applying at wind s peeds less that 3 miles per hour, the applicator must determine if a) conditions of temperature inversion exist, or b) stable atmospheric conditions exist at or below nozzle height. Do not make applications into areas of temperature inversions or stable atmospheric conditions." Spray Drift Label Language for Products Applied as a Spray through Aerial Equipment RELEASE HEIGHT: "Do not release spray at a height greater than 14 feet above the grou nd or canopy." BOOM LENGTH: Directions for Use under General Precautions and Restrictions "The boom length must not exceed 70% of the wingspan or 85% of the rotor blade diameter." SWATH ADJUSTMENT: "When applications are made with a cross - wind, the swath will be displaced downwind. 

### 45Description Required Labeling Language Placement on Label application area by adjusting the path of the aircraft upwind. Leave at least one unsprayed at the downwind edge of the treated field." The applicator must compensate f or this displacement at the downwind edge of the



### 46

### VI. Appendices

47

### A. Table of Use Patterns for Endothall Endothall Acid (PC 038901) Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle Alfalfa 15.9% SC/L Broadcast via Ground or Aircraft 0.7912 lb ae/A NS 1 - 2 Grown for seed only. Do not apply through any type of Foliar [4581 - 206] irrigation system. Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate w ater by cleaning of equipment or disposal of equipment wash waters. This product is toxic to fish. Do not contaminate water, food, or feed

by storage or disposal. This pesticide is toxic to wildlife. Do not feed treated forage to dairy animals or anima ls being finished for slaughter. Do not graze treated areas. Do not use seed for food, feed or oil purposes. Clover 15.9% SC/L Broadcast via 0.7912 lb NS 1 - 2 Same as "Alfalfa" Ground or Aircraft ae/A Foliar [4581 - 206] Cotton Pre -harvest 15.9% SC/L [4581 - 284] 0.0989 lb ae/A NS NS PHI=7 days Do not apply through any type of irrigation system. Do not apply

directly to water, or to areas where surface water is present or to intertidal areas below the mean 

### 48Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle high water mark. Do not contaminate water by cleaning of

equipment or disposal of wash waters. This product is toxic to fish. Do not contaminate water, food, or feed by storage or disposal. This pesticide is toxic to wildlife. Hops Foliar 15.9% SC/L [4581 - 206] Ground -Basal Spray Treatme nt 0.9494 lb ae/A NS 2 PHI=85 days Do not apply through any type of irrigation system. Do not apply

directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water by cleaning of equipment or disposal of equipment wash waters. This product is toxic to fish. Do not contaminate water, food, or feed

by storage or disposal. This pesticide is toxic to wildlife. Do not feed treated forage to dairy

animals being finished for slaug hter. Do not graze treated areas.



### 49Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle 15.9% SC/L 1 lb ae/A PHI=28 Do not apply through any type of [OR03003600] days irrigation system. Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean h igh water mark. Do not contaminate water by cleaning of equipment or disposal of equipment wash waters. This product is toxic to fish. This pesticide is toxic to wildlife. Do

not graze livestock in treated areas. Do not feed treated forage

and/or fodd er to animals being finished for slaughter. Potato (White/Irish) 15.9% SC/L Broadcast via Ground or Aircraft 1.0549 lb ae/A NS NS NS PHI=14 days Do not apply through any type of irrigation system. Do not apply Foliar [4581 - 206] directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water by cleaning of equipment or disposal of equipment wash waters. This product is toxic to fish. Do not contaminate water, food, or feed

b y storage or disposal. This pesticide is toxic to wildlife. Do not feed treated forage to dairy

animals being finished for slaughter. Do not graze treated areas. 

### 50Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle 

### Endothall Dipotassium Salt (PC 038904) Agricultural 40.3% S C/L Water treatment - 22.5 lbs NS NS NS NS Do not use treated water for

Drainage Surface or ae/mile spraying or irrigation within 25 Systems [4581 - 204] Subsurface - days after treatment. Do not Injection apply when drift is likely to occur. When Needed Equipment or Do not co ntaminate water, food, Sprayer or feed by storage or disposal. Drainage 40.3% SC/L Surface Water 3 ppm (L) NS NS NS NS NS Systems Treatment When Needed [FL87000500] 40.3% SC/L Water treatment - 57.6 lb Do not contaminate water, food, Surface -Aero sol ae/A or fed by storage or disposal [GA95000600] can, Aircraft, [TN94000200] Sprayer [NY98000200] [WA96000600] Subsurface Injection Equipment 10.1% G Surface Water Treatment 3.564 ppm (L)/A Do not use treated water for spraying o r irrigation within 7 [FL98000300] Spreader days after treatment. Do not contaminate water, food, or feed by storage or disposal. Human 40.3%SC/L Water Treatment 57.6 lb NS NS NS NS Do not contaminate water, food, Drinking ae/A or feed by storage or disposal. Do

Water [FL96001500] Surface - Aerosol not contaminate water intended Systems can, Aircraft for irrigation or domestic purposes. When Needed Subsurface Injection Equipment 

### 51Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle Irrigation 40.3% SC/L Water Treatment 1 L NS NS NS NS Systems [AL85000800] When Needed 40.3% SC/L Water Treatment 57.6 lb ae/A Do not contaminate water, food, or feed by storage or disposal. Do [GA95000600 0] [TN94000200] Surface -Aerosol can, Aircraft, Sprayer not contaminate water intend ed for irrigation or domestic purposes. Do not use treated [NY98000200] Subsurface Injection water for spraying or irrigation within 25 days after treatment. Do not apply when drift is likely 40.3% SC/L Equipment to occur. [4581 - 204] Lakes/Ponds/ 40.3% SC/L Surface Water 3 ppm (L) NS NS NS NS NS

Reservoirs Treatment (with Human [FL87000500]

or Wildlife 40.3% SC/L Water Treatment 57.6 lb Do not contaminate water, food, Use) Surface - ae/A or feed by storage or disposal. Do [GA95000600] Aerosol Can, not contaminate water intended When Needed [TN94000200] Aerial, Sprayer for irrigation or domestic [SC93000100] purposes. Do not use treated

[4581 - 204] Subsurface water for spraying or irrigation [NY98000200] Treatment within 25 days of treatment. Do [TX99000200] [WA96000600] not app ly when drift is likely to occur.



### 52Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle 63% G Surface Water 49.17 lb Do not contaminate water, food, [4581 - 388] [NY99000300] Treatment Broadcast, Granule Applicator ae/A or feed by storage or disposal. Do not contaminate water intended for irrigation or domestic [NY99000300] purposes. Do not use treated water for spraying or irrigation within 7 days of treatment. Do not apply when drift is likely to occur. 10.1% G Surface Water 58.104 lb Do not use treated water for Treatment - ae/A spraying or irrigation within 7 [4581 - 201] Spreader, Granula r days after treatment. Do not [FL98000300 Applicator apply when drift is likely to occur. (max 3.564 lb Do not contaminate water, food, ae/A)] or feed by storage or disposal. Streams/ 40.3% SC/L Surface Water 3 ppm (L) NS NS NS NS NS Rivers/ Treatment Channeled [FL87000500]

Water 40.3% SC/L Water Treatment 57.6 lb Do not contaminate water, food, [WA96000600] Surface - Sprayer Subsurface ae/A or feed by storage or disposal. Do not conta minate water intended When Needed for irrigation or domestic purposes. 10.1% G [FL98000300] Surface Water Treatment 3.564 ppm (ae) A Do not use treated water for spraying or irrigation within 7 days after treatment. Do not contaminate water, food, or feed by s torage or disposal. Swamps/ 40.3 % SC/L Surface Water 3 ppm (L) NS NS NS NS Do not contaminate water, food, Marshes/ Treatment or feed by storage or disposal. Do Wetlands/ [FL87000500] not contaminate water intended 

### 53Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle Stagnant 40.3% SC/L Water Treatment 57.6 lb for irrig ation or domestic

Water Surface - Sprayer (ae) A purposes. [WA96000600] Subsurface When Needed 

### Endothall N, N - dimethylalkylamine Salt (PC 038905) Agricultural 53% RTU Water Treatment 15.12 lb NS NS NS NS Apply to not more than 10 percent

Drainage ae/A - ft of surface area of water. Systems [AL81000900] 53 % SC/L 0.2 ppm NS (L) [IN80000800] Alfalfa 15.9% SC/L Broadcast 1.0549 lb NS NS NS NS Grown for seed only. Do not use ae/A treat ed seed for feed, food or oil Foliar [CA87003100] purposes. [NV87000800]

15.9% SC/L Broadcast - Ground, 0.6593 lb Aerial ae/A [ID87001900] [WA87003600]



### 54Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle 53% SC/L Ground - Spray 1.5 qt/L Do not apply through any type of [4581 - 381] (1.001 lb ae/A for i rrigation system. Do not apply

directly to water, or to areas where surface water is present or [AZ98000900] AZ98000 9000 to intertidal areas below the mean high water mark. Do not apply when drift is likely to occur. Do not contaminate water by cleaning of equipment or disposal of equipment wash waters. This product is toxic to fish. Do not contaminate water, food, or feed

by storage or disposal. This pesticide is toxic to wildlife. Do not use treated seed for feed, food 53% SC/L [4581 - 381] Aircraft Low Volume Spray 0.7507 lb ae/A or oil purposes. Do not graze treated areas. Do not feed forage

to dairy animals or to animals being finished for slaughter. Grown for seed only. Keep out of lakes, streams, and ponds. Alfalfa 53% SC/L Aerial - Spray 1.001 lb Grown for seed only. Do not Pre -harvest [WA98002900] Ground - Spray ae/A apply through any type of irrigation system. Keep out of [ID980 01300] lakes, streams, and ponds. Do not [NV98000200] [CA99000300] contaminate water by cleaning of equipment or disposal o f equipment wash waters. This product is toxic to fish. Do not contaminate water, food, or feed

by storage or disposal. This pesticide is toxic to wildlife. Do 

### 55Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle not use treated seed for feed, food or oil purposes. Do not graze treated areas. Do not fe ed forage

to dairy animals or to animals being finished for slaughter. Clover Foliar 53% SC/L [4581 - 381] Aircraft - Low Volume Spray 0.7507 lb ae/A NS NS NS NS Do not apply through any type or irrigation system. Do not apply

directly to w ater, or to areas Ground - Spray where surface water is present or to intertidal areas below the mean

high water mark. Do not apply when drift is likely to occur. Do not contaminate water by cleaning of equipment or disposal or equipment wash waters. This product is t oxic to fish. Do not contaminate water, food, or feed

by storage or disposal. This pesticide is toxic to wildlife. Do not use treated seed for feed, food

or oil purposes. Do not graze treated areas. Do not feed forage

to dairy animals or to animals be ing finished for slaughter. Commercial/ 53% SC/L Water Treatment - 3.0- 0.3 NS NS NS NS Do not discharge effluent

Industrial Metering Pump ppm containing this pesticide into

Water [4581 - 380] endothall sewage systems wit hout notifying Cooling technical the sewage treatment plant Systems authority (POTW). Do not discharge effluent containing this When Needed product into lakes, streams, ponds, estuaries, oceans, or public water 

### 56Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle (NPDES license restriction). This product is toxic to fish. Cotton Pre -harvest 15.9% SC/L [TX81003200] Aerial or ground Spray 0.1319 lb ae/A NS NS NS PHI= 3 Days Do not apply through any type of irrigation system. Do not apply

directly to water, or to areas where surface water is present or to intertidal areas below the mean high w ater mark. Do not contaminate water by cleaning of equipment or disposal of equipment wash waters. This product is toxic to fish. Do not contaminate water, food, or feed

by storage or disposal. This pesticide is toxic to wildlife. Drainage 53% RTU Surface Treatment - 15.12 lb NS NS NS NS Apply to not more than 10 percent Systems [AL81000900] Aerial, Boat ae/A - ft of surface area of water. [FL77000100] Wh en Needed Injection Equipment (max 11.2 lb ae/A - ft) 53% SC/L Surface Treatment - 3.1536 lb Do not use treated water for [1448 - 352] Injection Equipment, Ground (Sprayer) ae/A - ft domestic purposes until 25 days after treatment. Do not use treated water for spraying or irrigation within 25 days after treatment. Do not use treated



### 57Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle 53% SC/L 13.51 lb water for animal co nsumption [4581 - 174] [TX99000600] ae/A - ft within 25 days after treatment. Do not apply when drift is likely to occur. This product is toxic to fish. Do not contaminate water, food, or feed by storage or disposal. Do not use where fish are important resources. 11.2% G [4581 - 172] Water Treatment Aerial, Ground 13.5 lb ae/A - ft Do not apply when drift is likely to occur. This product is toxic to fish. Do not contaminate water, food, or feed by storage or disposal. Do n ot contaminate water intended for irrigation or domestic purposes. Hops 15.9% SC/L Basal Spray 0.3459 lb NS 2 NS PHI= 28 Treatment ae/A Days Foliar [ID87001500] [WA87001100] [OR87000400] Industrial 53% SC/L W ater Treatment - 3.0- 0.3 NS NS NS NS Do not discharge effluent Processing Water [4581 - 380] Metering Pump ppm endothall technical containing this pesticide into sewage systems without notifying the sewage treatment plant When Needed authority (POTW). Do not discharge effluent containing this produ ct into lakes, streams, ponds, estuaries, oceans, or public water (NPDES license restriction). This pesticide is toxic to fish. Do not contaminate water, food, or feed by storage or disposal. 

### 58Site Application

Timing Formulation [EPA Reg. No.] App. Type and Equipment Max. Single App. Rate (ae) Max. Number Apps. at

Max. Rate Max. Number Apps. per Year/Crop Cycle Max. Seasonal

Rate (ae) PHI, PGI, Pre feeding Interval Use Directions and Limitations Irrigation Systems When Needed 53% RTU [AL81000900] [FL7700 0100] Surface Treatment Aerial, Boat

Injection Equipment (max.

11.2 lb ae/A - ft) 15.2 lb ae/A - ft NS NS NS NS Apply to not more than 10 percent of surface area of water.

53% SC/L [IN8000800] [AZ79001000] Water Treatment 0.2 ppm (L) NS 53% SC/L [45 81 - 174] [TX99000600]

[1448 - 352] (max. 3.1536

lb ae/A - ft) Injection Equipment,

Sprayer 13.51 lb ae/A - ft Do not use treated water for domestic purposes until 25 days

after treatment. Do not use treated water for spraying or irrigation within 25 days af ter treatment. Do not use treated water for animal consumption within 25 days after treatment. Do not apply when drift is likely to occur. This product is toxic to fish. Do not contaminate water, food, or feed by storage or disposal. Do not use where fish are important resources. 11.2% G [4581 - 172] Water Treatment Aerial, Ground 13.5 lb ae/A - ft Do not apply when drift is likely to occur. This product is toxic to fish. Do not contaminate water, food, or feed by storage or disposal. Do not cont aminate water intended for irrigation or domestic purposes. 

### 59Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle Lakes/Ponds/ 53% RTU Surface Water 15.12 lb NS NS NS NS Apply to not more than 10 percent

Reservoirs Treatment - Aerial, ae/A - ft of surface area of water. (With [FL77000100] Boat Human or [AL81000900] Wildlife Use) Injection Equipment (max. When Needed 11.2 lb ae/A - ft) 53% SC/L Surface Water 8.008 lb Apply to not more than 10 percent [4581 - 174] Treatment - Sprayer ae/A - ft of surface water. Do not use treated water for domestic purposes unt il 25 days after treatment. Do not use treated water for spraying or irrigation within 25 days after treatment.

Do not use treated water for animal consumption within 25 days after treatment. Do not 53% SC/L Surface/Subsurface Treatment - Sprayer, 1.588 lb ae/A - ft [1448 - 352] Injection apply when drift is likely to occur. Equipment This product is toxic to fish. Do not contaminate water, food, or 53% SC/L 6.807 lb ae/A - ft feed by storage or disposal. Do [TX99000600 ] not use where fish are important resources. 11.2% G [TX99000500] Water Treatment by hand 162 lb/A ft (L) Buffer zone restriction (600 feet) on TX SLN. Do not contaminate water, food, or feed by storage or [4581 - 172] disposal. Do not apply when drift is likely to occ ur. This product is toxic to fish. Do not contaminate

water intended for irrigation or domestic purposes. Potato 53% SC/L Aerial - Low 1.001 lb NS 1 NS PHI=14 Do not apply through any type or 

### 6 0Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations Application [EPA Reg. Equipment Single Number Number Seasonal Pre Timing No.] App. Apps. at Apps. per Rate feeding Rate Max. Year/Crop (ae) Interval (ae) Rate Cycle (White/Irish) Volume Spray ae/A Days irrigation system. Do not apply Foliar [4581 - 381] Ground - Spray directly to water, or to areas where surface water is present or to intertidal areas below the mean

high water mark. Do not apply when drift is likely to occur. Do not contaminate water by cleaning of equipment ordisposal of equipment wash waters. This product is toxic to fish. Do not contaminate water, food, or feed

by storage or disposal. This pesticide is toxic to wildlife. Do not graze treated areas. Do not feed forage to dairy animals or

animals being fi nished for slaughter. Swamps/Mar 11.2% G Water Treatment ­ 162 lb NS NS NS NS Buffer zone restriction (600 feet). shes/Wetland Hand Application ae/A - ft Do not contaminate water, food,

s/Stagnant [TX99000500] (L) or feed by storage or dis posal.

Water When Needed



### 61

### 62

### B. Generic Data Requirements and Studies Used to Make the Reregistration Decision Guide to Appendix B Appendix B contains listing of data requirements which support the reregistration for active ingredients within case 2245 Endothall covered by this RED. It contains generic data requirements that apply to Endothall in all products, including data requirements for which a “typical formula tion” is the test substance. The data table is organized in the following formats: 1. Data Requirement (Column 1). The data requirements are listed in the order in which they appear in 40 CFR part 158. The reference numbers accompanying each test re fer to the test protocols set in the Pesticide Assessment Guidance, which are available from the National technical Information Service, 5285 Port Royal Road, Springfield, VA 22161 (703) 487 - 4650. 2. Use Pattern (Column 4). This column indicates the use patterns for which the data requirements apply. The following letter designations are used for the given use patterns. A. Terrestrial food B. Terrestrial feed C. Terrestrial non - food D. Aquatic food E. Aquatic non - food outdoor F. Aquatic non - food industrial G. Aquatic non - food residential H. Greenhouse food I. Greenhouse non - food J. Forestry K. Residential L. Indoor food M. Indoor non -food N. Indoor medical O. Indoor residential 3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this column list the identify number of each study. This normally is the Master Record Identification (MRID) number, but may be a “GS” number if no MRID number has been assigned. Refer to the Bibliography appendix for a complete citation of the study.



### 63

### New Old Requirement Use Bibliographic Citation(s) Guideline Guideline Pattern Number Number PRODUCT CHEMISTRY 830.1550 61 - 1 Product Identity and Compositio n A, B, E, F, G 41616401 830.1600 61 - 2 A Description of Starting Material A, B, E, F, G 41616401, 43873901, 43873902 830.1620 61 - 2 B Description of Production Process A, B, E, F, G 41616401, 43873901, 43783902 830.1670 61 - 2 B Discussion of A, B, E, 41616401, 43873901, 43873902 Formation of F, G Impurities 830.1700 62 - 1 Preliminary Analysis A, B, E, F, G 41616402, 42427901, Data Gap for 4581 - 204, 4581 - 174, 4581 - 380, 4581 - 381 830.1750 62 - 2 Certified Limits A, B, E, F, G 41616402 830.1800 62 - 3 Enforcement of Analytical Method A, B, E, F, G 41616402, 42427901 830.6302 63 - 2 Color A, B, E, F, G 42629701, 42629901, 42629801 830.6303 63 - 3 Physical State A, B, E, F, G 42629701, 42629901, 42629801 830.6304 63 - 4 Odor A, B, E, F, G 42629701, 42629901, 42629801 830.6313 63 - 13 Stability A, B, E, F, G 43265001, 43264901, 43265101, Data Gap for 4581 - 174, 4581 - 380, 4581 - 381, 4581 - 204 830.7000 63 - 12 pH A, B, E, F, G 42629701, 42629901, 42629801 830.7200 63 - 5 Melting Point A, B, E, F, G 42629701, 42629901, Data Gap for 4581 - 174, 4581 - 380, 4581 - 381 830.7220 Boiling Point A, B, E, F, G Data Gap for 4581 - 174, 4581 - 380, 4581 - 381 830.7300 63 - 7 Density A, B, E, 42629701, 42629901, 42629801 F, G 830.7550/ 7560/757 0 63 - 11 Partition Coefficient A, B, E, F, G 43472803, 434 41501 830.7370 63 - 10 Dissociation Constant A, B, E, F, G 42668001, 42787702, 43081301 830.7840/ 7860 63 - 8 Water Solubility A, B, E, F, G 41622801, 43339301, 43551701, 43472802 830.7950 63 - 9 Vapor Pressure A, B, E, F, G 41622802, 43319601 830.7050 None UV/Visible A, B, E, Data Gap for 4581 - 257, 4581 - 204, 4581 - 174, Absorption F, G 4581 - 380, 4581 - 381 ECOLOGICAL EFFECTS 

### 64

### New Old Requirement Use Bibliographic Citation(s) Guideline Guideline Pattern Number Number 850.4100 122 - 1A Seedling Emergence A, B, E, F, G 850.4150 122 - 1B Vegetative Vigor A, B, E, F, G 850.4230 123 - 1 Early Seedling A, B, E, Growth Toxicity F, G 850.2100 71 - 2 Avian Acute Dietary A, B, E, 43167701, 43167702, 43167801, 43167802, Toxicity F, G 43167901,43167902, 00035240, 00035241, 00116270, 00116271, 00035238, 00035239 850.2100 71 - 1 Avian Acute Oral A, B, E, 0160000, 42359501, 00035237, 42359701*, Toxicity F, G 00074220*, 42359601* 850.2300 71 - 4 Avian Reproduction A, B, E, F, G 42507301, 42507302*, Data Gap for N,Ndimethylalkylamine 850.1075 72 - 1 Freshwater Fish A, B, E, 442327701, 42327702, 40098001 , 40094602, Acute Toxicity F, G 00068507*, 114510*, 113971*, 43472801, 00084149, 00084148, 0084147, 00007113, 43196901, 00046269*, 00071148*00083025*, 42695401, 42695402, 00071134* 850.1010 72 - 2A Freshwater A, B, E, 42359702, 42695403, 00035242, 00074221, Invertebrate Acute F, G 00074222, 00074227*, 00074228*, Toxicity Test 43196902*, 05009242, 40098001, 00071137*, 00115863*, 00017800*, 00084150*, 00084151 850.1075 72 - 3 A Estuarine/Marine A, B, E, 42914102, 42695405, 43196903, 00074225, Fish Acute Toxicity F, G 4470040 1*, 00074226, 40098001 Test Estuarine/Marine A, B, E, 00074223*, 0074224*, 42895201, 42914101, Invertebrate Acute F, G 43210001, 00035243, 00035244*, 43550201, Toxicity 42695406, 42695404 850.1350 Estuarine/Marine Data Gap for N,N - dimethylalkylamine Invertebrate Early Life Stage Study 850.1025 72 - 3B Estuarine/Marine Toxicity - Mollusk A, B, E, F, G 42895201, 42695404, 43550201 72 - 3C Estuarine/Marine A, B, E, 42914101, 42695046, 43210001 Toxicity - Shrimp F, G 850.1400 72 - 4A Freshwater Fish A, B, E, 43295401, 00095812, 43276501, Data Gap for Early Life - S tage F, G N,N- dimethylalkylamine Test 850.1500 Freshwater Fish Life Data Gap for N,N - dimethylalkylamine Cycle Test 72 - 4C Freshwater A, B, E, 43007801, 43437901 Invertebrate Life - F, G Cycle Test 850. 1735 Freshwater Acute Data Gap for N,N - dimethylalkylamine Sediment Test 850.1400 Estuarine/Marine Data Gap for N,N - dimethylalkylamine Acute Sediment Test 

### 65

### New Old Requirement Use Bibliographic Citation(s) Guideline Guideline Pattern Number Number EPA/600/ Chronic Data Gap for N,N - dimethylalkylamine R01/020 Estuarine/Marine Sediment Testing EPA/600/ 65 - day Test in Data Gap for N,N - dimethylalkylamine

- 99/064 Chironomous Tentans Non - Non - Acute Toxicity to 40098001 Guideline Guideline Amphibians 850.3020 141 - 1 Honey Bee Acute Contact Toxicity A, B, E, F, G 44038201 850.4400 122 - 2 Aquatic Pl ant Growth A, B, E, F, G 41613809, 44392802 850.4225 123 - 1A Seedling A, B, E, 42396405, 43870401, 44392803, 44127801 Germination/ F, G Seedling Emergence (Tier II) 850.4250 123 - 1B Vegetative Vigor (Tier II) A, B, E, F, G 42396405, 43870401 Aquatic Pla nt A, B, E, 41613809, 42396401*,42396402*, 42396404, Toxicity (Tier I) F, G 42396403*, 44392801, 44392802 850.4400 123 - 2 Aquatic Plant Toxicity (Tier II) A, B, E, F, G 42396406, 44949402, 44949203, 44127802*, 44127803*, 44127805*, 44127804*, 4427806*, 449 76701, 44949202, 44949201, Acc. 244122*, 44408801 OCCUPATIONAL/RESIDUE EXPOSURE 875.1600 236 Application 44972201, 45250701 Exposure Monitoring Data Reporting TOXICOLOGY 870.1100 81 - 1 Acute Oral Toxicity Rat A, B, E, F, G 42289201 N/A N/A Maximum To lerated A, B, E, 40745201 Oral Dose Toxicity ­ F, G Dog 870.1200 81 - 2 Acute Dermal Toxicity - Rabbit/Rat A, B, E, F, G 42289202 870.1300 81 - 3 Acute Inhalation Toxicity - Rat A, B, E, F, G 42169501, 42408701 870.2400 81 - 4 Acute Eye Irritation

- Rabbit A, B, E, F, G 42289203 870.2500 81 - 5 Acute Dermal Irritation A, B, E, F, G 42289204 (unacceptable) 870.2600 81 - 6 Dermal Sensitization A, B, E, F, G 41871901 

### 66

### New Old Requirement Use Bibliographic Citation(s) Guideline Guideline Pattern Number Number 870.3100 82 - 1A 90 - Day Feeding ­ Rodent A, B, E, F, G 43480810 870.3150 82 - 1B 90 - Day Feeding - Non - rod ent A, B, E, F, G 43480801, 43480802 870.3200 82 - 2 21 - Day Dermal - Rabbit/Rat A, B, E, F, G 42814101, 43465201 870.3465 28 - day Inhalation Data Gap 870.4100 83 - 1B Chronic Feeding A, B, E, 40745202 B Toxicity ­ Non - F, G Rodent 870.3700 83 - 3A Prenatal A, B, E, 42776301 Developmental F, G Toxicity - Rat 870.4200 83 - 2B Oncogenicity ­ Mouse A, B, E, F, G 40685301, 43608301 870.3700 83 - 3B Developmental Toxicity - Rabbit A, B, E, F, G Data Gap 870.3800 83 - 4 2 - Generation Reproduction - Rat A, B, E, F, G 43152101, 43629301 870.4300 83 - 5 Combined Chronic A, B, E, 41040301 Toxicity/ F, G Carcinogenicity 870.5300 84 - 2 Gene Mutation (In vitro) A, B, E, F, G 43437801 870.5100 84 - 2 Bacterial Gene Mutation Assay A, B, E, F, G 43154801 (unacceptable) 870.537 5 84 - 2B In vitro Mammalian Cytogenetics A, B, E, F, G 41700302 870.5395 84 - 2 In vivo Cytogenetics A, B, E, 43157401, 41700301

- Micronucleus F, G Assay in Mice 870.7485 85 - 1 Metabolism and pharmacokinetics A, B, E, F, G 42169502, 44263501, 42200101 870. 7600 85 - 3 Dermal Penetration A, B, E, F, G 42169503 ENVIRONMENTAL FATE Dissociation - Non - A, B, E, 42668008, 43551501, 43081301 guideline F, G NONE 201 - 1 Droplet Size Spectrum A, B, E, F, G 42427601 835.2120 161 - 1 Hydrolysis A, B, E, F, G 44578401, 4 2289106 835.4100 162 - 1 Aerobic Soil Metabolism A, B, E, F, G 44949401 835.4400 162 - 3 Anaerobic Aquatic Metabolism A, B, E, F, G 42903901 

### 67

### New Guideline Number Old Guideline Number Requirement Use Pattern Bibliographic Citation(s) 835.4300 162 - 4 Aerobic Aquatic Metabolism A, B, E, F, G 42618901 835.2240 161 - 2 Aqueous Photolysis A, B, E, F, G 42 289205, 42289205, 42289205, 42641201, Acc 259367 835.1230 163 - 1 Sediment and Soil Adsorption/ Desorption for Parent and Degradates A, B, E, F, G 41616404

835.6100 164 - 1 Terrestrial Dissipation A, B, E, F, G 42670101, 42670201 835.6200 164 - 2 Aquatic Fiel d Dissipation A, B, E, F, G 44093403, 44093402, 44820103, 44828802, 44828801, 44820101 NONE 165 - 4 Bioconcentration in Fish A, B, E, F, G 42644001, 43315801 RESIDUE CHEMISTRY 860.1300 171 - 4A Nature of Residue ­ Plants A, B, E, F, G 00040978, 00108102, 00 113954, 00113965, 42619201, 42619202, 42619203, 43346601, 44077801 860.1300 171 - 4B Nature of Residues ­ Animals A, B, E, F, G 00035451, 00035452, 00113928, 00113963, 00133190, 42792701, 42816601 860.1340 171 - 4C Residue Analytical Method - Plants A, B, E, F, G 45156001, 44320401, 44320402, 44320403, 44322001, 44322002, Data Gap for conversion of monomethyl ester to endothall 860.1340 171 - 4D Residue Analytical Method - Animal A, B, E, F, G 45156001, Data Gap for conversion of monomethyl ester to endothall 

### Data collection and regulatory analytical methods are needed for the determination of endothall, per se, in animal commodities 860.1340 Independent Laboratory Validation A, B, E, F, G 

### Submission of analytic reference standards for dipotassium an d mono N,N- dimethylalkylamine salts of endothall are needed 860.1360 171 - 4M Multi - residue Method A, B, E, F, G 44608601 860.1850 165 - 1 Confined Rotational Crop 43300701, Data Gap 860.1340 Data Gap - Independent Laboratory Validation (ILV) of an e nforcement method for the determination of endothall and its monomethyl ester in fish is needed to support proposed tolerances on fish. 

### 68

### New Old Requirement Use Bibliographic Citation(s) Guideline Guideline Pattern Number Number 860.1380 171 - 4E Storage Stability A, B A, B, E, F, G 43975901, 44077801, 44106301, 44263502, 44263503, 44263504, 44 263505, 44274401, 45146302, Data Gap for additional studies on processed plant commodities, animal commodities, and fish. 44343101, 44263506, 44334301, 44263508, 860.1400 171 - 4H Magnitude of A, B, E, 44263507, Data Gap Residue in Irrigated F, G Crops 

### Data Gap 860.1480 171 - 4J Magnitudes of residues in Meat, Milk, Poultry, Eggs A, B, E, F, G Milk and the Fat, Meat, and Meat Byproducts of Cattle, Goats, Hogs, Horses and Sheep Eggs and the Fat, Meat, and Meat Byproducts of Poultry 860.1400 171 - 4 G Magnitude of Residues in Fish A, B, E, F, G 44820102, 43315801 Data Gap 860.1650 171 - 13 Analytical Reference A, B, E, Standards F, G 860.1500 171 - 4K Crop Field Trials A, B 43953101, 45146301, 43975901, 44103701, 44037402, 45034701, 43953101 44093401, 44012101, 45146302, 44037401, 860.1520 171 - 4L Processed Food/Feed A, B, Data Gap (potato, alfalfa seed, cottonseed, and cotton gin products, apples, field corn, grapes, orange, rice, sorghum, soybeans, sugar beet, tomato, and wheat)



### 69

### C . Technical Support Documents Additional documentation in support of this RED is maintained in the OPP Regulatory Docket, located in Room 119, Crystal Mall #2, 1801 South Bell Street, Arlington, VA 22202 - 4501. It is open Monday through Friday, excluding legal holidays, from 8:30 am to 4:00 pm. The docket initially contained preliminary human health and ecological effects risk assessments and related documents that were published May 11, 2005. The publ ic comment period closed sixty (60) days later on July 11, 2005. The EPA then considered comments and revised the risk assessments where appropriate. Final human health and ecological risk assessments, as well as additional support documents, will be pub lished in the docket with this RED. These documents include: Phase 3 Public Comment Documents: 1. Environmental Fate and Ecological Risk Assessment for Endothall - Revised, dated April 22, 2005 2. Environmental Fate and Effects Division Error- Only Corre ctions of the Endothall RED, dated April 22, 2005 3. Endothall: HED Chapter for the Reregistration Eligibility Decision Document (RED), dated April 18, 2005 4. Endothall - Report of the Hazard Identification Assessment Review Committee, dated June 14, 2004 5. Endothall - Report of the Health Effects Division (HED) Risk Assessment Review Committee (RARC), dated November 4, 2004 6. Drinking Water Assessment for Endothall for both Terrestrial and Aquatic Uses, dated May 5, 2004 7. Endothall and its salts: Ch ronic Dietary Exposure Assessment for the Reregistration Eligibility Decision. Revised per Registrant Corrections, dated April 11, 2005 8. Endothall and its salts: Residue Chemistry Considerations for Reregistration Eligibility Decision. Revised per Regis trant Comment for Error Only, dated April 11, 2005 9. Revised Occupational and Residential Exposure Assessment and Recommendations for the Reregistration Eligibility Decision Document for Endothall, dated April 1, 2005 70

### 2005 10. Occupational and Residential Ex posure Assessment - Response to Registrant's ErrorOnly Comments, dated March 18, 2005 11. Endothall and Salts: Occupational and Residential Exposure Assessment of Antimicrobial Uses for the Reregistration Eligibility Decision, dated March 3, 2005 12. Ecol ogical Risk from Antimicrobial Uses of Endothall to be Considered in the RED Document, dated January 12, 2005 13. Review of Endothall (and salts) Incident Reports, dated June 24, 2005 Final Risk Assessments and Additional Supporting Documents: 1. Endoth all: HED Chapter of the Reregistration Eligibility Decision Document (RED). Corrected Following Pub lic Comments, dated September 30 , 2005 2. Endothall: HED Response to Public Comments, dated August 26, 2005 3. Environmental Fate and Effects Division Resp onse to Public Comment for the Endothall RED, dated August 6, 2005 4. Revised Occupational and Residential Exposure Assessment and Recommendations for the Reregistration Eligibility Decision Document for Endothall, dated August 12, 5. Amended Respon se to a Submitted Dietary Exposure Assessment and a Comment on Fish Consumption in the US, dated July 25, 2005 6. Response to the Four Residue Chemistry Comments from Cerexagri in their "Response to the EPA's RED Comments for Endothall," dated August 30, 2005 7. Endothall and its Salts. Residue Chemistry Considerations for Reregistration Eligibility Decision. Revised per Registrant Comments, dated August 30, 2005 8. Endothall: Toxicology Disciplinary Chapter for the Reregistration Eligibility Decision Do cument (RED), dated December 21, 2004 9. Endothall, Acute Mammalian Toxicity Batching Appendix for Endothall RED Document, dated September 21, 2005 10. Meeting with Army Corp of Engineers, Meeting Minutes, dated July 27, 2005 11. Revised Endothall and S alts: Occupational and Residential Exposure Assessment of Antimicrobial Uses for the Reregistration Eligibility Decision Document, dated September 28, 2005 71

### 12. Addendum to Chronic Dietary Risk Assessment, dated September 2 9, 2005 13. Closure Call Meetin g Minutes, dated September 26, 2005 14. Addendum to Drinking Water Assessment, dated September 29, 2005

72

### D.Bibliography GUIDE TO APPENDIX D 1. CONTENTS OF BIBLIOGRAPHY. This bibliography contains citations of all studies considered relevant by EPA in arriving at the positions and conclusions stated elsewhere in the Reregistration Eligibility Document. Primary sources for studies in this bibliography have been the body of data submitted to EPA and its predec essor agencies in support of past regulatory decisions. Selections from other sources including the published literature, in those instances where they have been considered, are included. 2. UNITS OF ENTRY. The unit of entry in this bibliography is call ed a “study.” In the case of published materials, this corresponds closely to an article. In the case of unpublished materials submitted to the Agency, the Agency has sought to identify documents at a level parallel to the published article from within the typically larger volumes in which they were submitted. The resulting “studies” generally have a distinct title (or at least a single subject), can stand alone for purposes of review and can be described with a conventional bibliographic citation. The Agency has also attempted to unite basic documents and commentaries upon them, treating them as a single study. 3. IDENTIFICATION OF ENTRIES. The entries in this bibliography are sorted numerically by Master Record Identifier, or “MRID” number. This num ber is unique to the citation, and should be used whenever a specific reference is required. It is not related to the six - digit “Accession Number” which has been used to identify volumes of submitted studies (see paragraph 4(d)(4) below for further explan ation). In a few cases, entries added to the bibliography late in the review may be preceded by a nine character temporary identifier. These entries are listed after all MRID entries. This temporary identifying number is also to be used whenever specifi c reference is needed. 4. FORM OF ENTRY. In addition to the Master Record Identifier (MRID), each entry consists of a citation containing standard elements followed, in the case of material submitted to EPA, by a description of the earliest known submiss ion. Bibliographic conventions used reflect the standard of the American National Standards Institute (ANSI), expanded to provide for certain special needs. a. Author. Whenever the author could confidently be identified, the Agency has chosen to show a personal author. When no individual was identified, the Agency has shown an identifiable laboratory or testing facility as the author. When no author or laboratory could be identified, the Agency has shown the first submitter as the author. b. Document date. The date of the study is taken directly from the document. When the date is followed by a question mark, the bibliographer has deduced the date from the evidence contained in the document. When the date appears as (1999), the Agency was unable to determine or estimate the date of the document. 73

### c. Title. In some cases, it has been necessary for the Agency bibliographers to create or enhance a document title. Any such editorial insertions are contained between square brackets. d. Trailing parenth eses. For studies submitted to the Agency in the past, the trailing parentheses include (in addition to any self - explanatory text) the following elements describing the earliest known submission: (1) Submission date. The date of the earliest known submi ssion appears immediately following the word “received.” (2) Administrative number. The next element immediately following the word “under” is the registration number, experimental use permit number, petition number, or other administrative number associ ated with the earliest known submission. (3) Submitter. The third element is the submitter. When authorship is defaulted to the submitter, this element is omitted. (4) Volume Identification (Accession Numbers). The final element in the trailing parent heses identifies the EPA accession number of the volume in which the original submission of the study appears. The six - digit accession number follows the symbol “CDL,” which stands for “Company Data Library.” This accession number is in turn followed by an alphabetic suffix which shows the relative position of the study within the volume.

74

### Bibliography Citations for Endothall Acid MRID Citation Receipt Date 4459 Wright, W.G. (1966) Summary of 1966 Weed Control Trials. (Unpublished study received Nov 6, 1967 under 464- 398; prepared by South Dakota State Univ., Dept. of Agronomy, submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:003622- C) 06 - Nov 1967 Hamson, A.R. (1954) News and Views about New York's Second Most Important Ag ricultural Industry: Dry Bean Defoliation. (Cornell VegNews 5(7):1 - 3; unpublished 4573 study including letter dated Sep 13, 1954 from A.R. Hamson to unknown recipient, received Jul 28, 1960 under 359 - 400; prepared by Cornell Univ., New York State 28 -Jul 1960 Agricultural E xperiment Station, Dept. of Vegetable Crops, submitted by Rhone - Poulenc, Inc., Monmouth Junction, N.J.; CDL:023310 - F) Welker, W.V.; Holm, L.G. (19) Pre - Emergence Herbicide Treatments on Red Beets. 9984 (Unpublished study received Dec 23, 1957 under 524 - 96; prepared by Univ. of Wisconsin, Agricultural Experiment Station, Dept. of Horticulture, submitted by Monsanto Co., St. Louis, Mo.; CDL:223118 - Y) 23 - Dec 1957 15941 E.I. du Pont de Nemours & Company (1954) Spinach Weed Control. (Unpublished study received Jun 14, 1955 under 352 - 197; CDL: 002773 - G) 14 -Jun 1955 19227 Counselman, C.J.; Kincaid, L.R.; Geary, R.J.; et al. (19) Herbicidal Activity of Chloroxuron (N - 4(~p~ - Chlorophenoxy) -phenyl-N',N' - dimethylurea) and C - 2059 (N- 3 - Trifluoromethylph enyl) - N', N'- dimethylurea) in Seven Areas of the United States. (Unpublished study received Jun 29, 1964 under unknown admin. no.; submitted by Ciba Agrochemical Co., Summit, N.J.; CDL:127559 - B) 29 -Jun 1964 08 - Oct 1964 11 - May 1965 Grehlinger, P.M.; Johnson, R.; Messinger, D.; et al. (1970) Summary of Tandex Efficacy 20211 Data -- Ragweed. (Unpublished study received Apr 17, 1972 under 279- 2717; prepared in cooperation with Amchem and others, submitted by FMC Corp., Philadelphia, Pa.; CDL: 17 - Apr1972 002491 - B) 22290 Lyle, M.; Walter, G. (1974) Eptam 10 G Fall Application on Sugar -beets: Crop Tolerance and Weed Control Summary. (Unpublished study received Feb 20, 1976 under 476- 1620; submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:223820 - D) 20 - Feb 1976 22917 University of Nebraska, Department of Agronomy (1961) Weed Control in Castorbeans in Nebraska in 1961. (Unpublished study received Mar 18, 1965 under 400 - 46; submitted by Uniroyal Chemical, Beth -any, Conn.; CDL:003233 - B) 18 - Mar1965 Collins, H.A.; Kincaid, L.R.; Colby, C.M. et al. (1978) Biological Research Report on 23939 Herbicide Efficacy. (Unpublished study received Jan 11, 1978 under 100 - 437; prepared in cooperation with Missouri, Dept. of Conservation and others, submitted by Ciba - Ge igy 11 -Jan 1978 Corp., Greensboro, N.C.; CDL:232638 - A) Sutton, D.L.; Evrard, T.O.; Chappell, W.E. (1959) Weed Control Studies in Farm Ponds 24085 Using Simazine and Other Herbicides. (Unpublished study received Apr 29, 1965 under 100 - 437; prepared by Vir ginia Polytechnic Institute, Agricultural Experiment Sta - tion, 29 - Apr1965 submitted by Ciba - Geigy Corp., Greensboro, N.C.; CDL: 000232 - A) Gallagher, J.E.; Otten, R.J. (1963) Weed Control in Bermuda and Zoysia Grasses. 24094 (Unpublished study received Dec 19, 1963 under 264 - 156; prepared in cooperation with Amchem Products, Inc., submitted by Union Carbide Agricultural Products Co., Ambler, 19 - Dec 1963 Pa.; CDL:002123 - A) 

### 75Timmons; Weldon; Lee; et al. (1959) Herbicides to Control Weeds. (Unpublish ed study 20 - Nov 24109 received Nov 20, 1959 under 264- 119; prepared in cooperation with U.S. Fish and Wildlife Service and Delaware, Board of Game and Fish Commissioners, submitted by 1959 03 - Dec Union Carbide Agricultural Products Co., Ambler, Pa.; CDL: 001891 - F) 1959 Davis, H.C.; Hidu, H. (19) Effects of pesticides on embryonic development of Clams and 25816 Oysters and on survival and growth of the Larvae. Fishery Bulletin 67(2):393 - 400,403. (also in unpublished submission received Jan 2, 1980 under 2217 - 485 ; submitted by PBI 02 -Jan 1980 Gordon Corp., Kansas City, Kans.; CDL:241581 -W) 26244 Miller, C.W.; Lowe, J.I. (19) Toxicity of Herbicides to Estuarine Animals. (U.S. Bureau of Commercial Fisheries, unpublished report.) 05 -Jan 1968 Washington Stat e University, Agricultural Extension Service (1965) Washington State 27000 Weed Control Recommendations for Central and Eastern Washington: Weed Control in Seed. Rev. Pullman, Wash.: WSU, AES. (E.M. 2179; pp. 52 - 53 only; also in unpublished submission received O ct 2, 1967 under 8F0643; submitted by Stauffer Chemical Co., 02 - Oct 1967 Richmond, Calif.; CDL:091116- AP) Walker, C.R. (1966) Aquatic Weed Control. (Summary of unpublished paper presented at 28032 the 23rd Annual North Central Weed Control Conference; 19 66; unpublished study received may 28, 1968 under 352- 247; prepared by Illinois, Natural History Survey and U.S. Fish and Wildlife Service, submitted by E.I. du Pont de Nemours & Co., 28 - May 1968 Wilmington, Del.; CDL:002855 - G) Fults, J.; Blouch, R .; Thornton, B. (1952) Summary of Data Relative to use of Karmex W 28065 Herbicide and Karmex DW Herbicide on Potatoes. (Unpublished study received Feb 4, 1956 under PP0062; submitted by E.I. du Pont de Nemours & Co., Wilmington, Del.; 04 - Feb 1956 CDL:090060 - B) Frank, P.A. (1971) Evaluation of Aquatic Herbicides. (Unpublished paper prepared for 28441 the Weed Science Society meeting; Feb 3 - 5, 1970, Montreal, Canada; unpublished study received Jul 13, 1971 under 1E1046; prepared by U.S. Agricultural Research Ser vice, Crops Protection Branch, submitted by U.S. Dept. of the Army, Office of the Chief of 13 -Jul 1971 Engineers, Washington, D.C.; CDL: 091865 - C) 29786 Sibbald, J.H. (1968) Test Report: MSMA as a Silvicide. (Unpublished study received Dec 4, 1968 under 6308- 58; submitted by Ansul Chemical Co., Weslaco, Tex.; CDL:007869- A) 04 - Dec 1968 Chisholm, K.W.; Ekins, W.L. (1979) Nortron EC + Betanex and/or Bet - anal 31570 Postemergence EUP Program for 1978 and 1979: Efficacy and Crop Safety Data. (Unpublished stu dy received Jan 2, 1980 under 10065 - EX - 4; submitted by Fisons Corp., 02 -Jan 1980 Agricultural Chemicals Div., Bedford, Mass.; CDL:241688- A) Blackburn, R.D.; Weldon, L.W. (1964) Control of Southern Naiad in Florida drainage 31855 and irrigation channels. Weeds 12(4):295 - 298. (also in unpublished submission received Sep 15, 1972 under 1F1101; submitted by Chevron Chemical Co., Richmond, Calif.; 15 - Sep 1972 CDL:090862 - AE) Younger, V.B. (1958) Kikuyugrass, Pennisetum clandestinum, and its control. Sou thern 32062 California Turfgrass Culture 8(1):1 - 2. (also in unpublished submission received Feb 20, 1959 under 464- 164; submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:022959- 20 - Feb 1959 A) Stewart, D.; Nelson, R.T.; Laumeister, L.T.; et al. (1961) Weed Control in Plants. 32563 (Unpublished study including published data, received Feb 14, 1961 under 4581 - 79; prepared in cooperation with U.S. Agricultural Research Service, Field Crops Re -search 14 - Feb 1961 Branch, Sugar Crops Section and others, submitted by Pennwalt Corp., Agchem Div., 

### 76King of Prussia, Pa.; CDL:007437- A) Stroube, E.W.; Zielke, R.C.; Nylund, R.E.; et al. (1964) Efficacy Study. (Unpublished 33985 study received Nov 25, 1964 under 4581 -234; prepared in cooperation with Ohio State Univ., A gricultural Experiment Station and others, submitted by Pennwalt Corp., 25 - Nov 1964 Agchem Div., King of Prussia, Pa.; CDL:026043 - A) 34138 Union Carbide Agricultural Products Company (1958) Clover Control with 2,4,5 - TP. (Unpublished study received Jul 9, 1958 under 264- 76; CDL:001871 - A) 09 -Jul 1958 Fink, R. (1975) Final Report: Eight - Day Dietary LCI50 -- Mallard Ducks: Project No. 110 ­ 35233 106. (Unpublished study received Oct 21, 1975 under 4581 - EX - 18; prepared by Truslow Farms, Inc., submitted by Pennwa lt Corp., Agchem Div., King of Prussia, Pa.; CDL: 21 - Oct 1975 096340 - B) Keckemet, O. (1975) Substantive Amendment to Pesticide Petition No. 3F1416 (Also 35234 Designated as Pesticide Petition No. 4G1449 -Temporary Tolerance and Temporary Permits 4581 - EXP - 18G and 4581 -EXP - 21G). (Unpublished study received Oct 21, 1975 under 4581 -EX - 18; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 21 - Oct 1975 CDL:096340 - C) 35236 Pennwalt Corporation (1975) Fish and Wildlife Safety. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096705 - A) 05 -Jan 1978 35245 Pennwalt Corporation (1970) Beneficial Insect Safety. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096705 - K) 05 -Jan 1978 35249 Pennwalt Corporation (1952) Accident Exposure Experience: (Endothall). (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096705 - L) 05 -Jan 1978 35405 Syracuse University Research Corporation (1969) Fate of Herbicides in the Aquatic Environment. (In cooperation with New York State, Conservati on Dept., unpublished study; CDL:091753 - F) 27 - Nov 1973 35427 Pennwalt Corporation Product Chemistry: Data Requirements. (Unpublished study received Jan 5, 1978 under 1F1105; CDL: 096703 - A) 05 -Jan 1978 35428 Pennwalt Corporation (1977) Quality Control Specifications for Furan. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - B) 05 -Jan 1978 35429 Pennwalt Corporation (1962) Analysis of Endothall acid, PF - 3441. (Unpublished study received Jan 5, 1978 under 1F1105; CDL: 096703 - C) 05 -Jan 1978 35430 Pennwalt Corporation (1976) Analytical Procedure for Endothall Technical. Method dated Apr 1976. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - D) 05 -Jan 1978 35432 Whitaker, R.L. (1977) Product Stability. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096703 - G) 05 -Jan 1978 35434 Pennwalt Corporation (19) Product Chemistry: Data Requirements. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - I) 05 -Jan 1978 Pennwalt Corporation (1970) A Rapid Method for the Determination of Primary, Secondary and Tertiary Aliphatic Amines in Mixtures. Calculation of Neutralization 35435 Equivalents and Amine Numbers. Method A - 26 dated Mar 23, 1970. (U npublished study including letters dated Dec 2, 1976 from W. Whitla to Harold Lindaberry and Jun 2, 1977 05 -Jan 1978 from L.D. Metcalfe to Harold Linda -berry, received Jan 5, 1978 under 1F1105; CDL:096703 - L) 

### 77Pennwalt Corporation (1976) Analytical Procedure for Hydrothol(R) 191 Liquid, 35436 Hydrothol 191 Granular (Hydrothol 191 Rice Herbicide), and Herbicide 283. Method dated Apr 1976. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - 05 -Jan 1978 M) 35439 Pennwalt Corporation (1975) Resi due Chemistry: I. Summary. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - P) 05 -Jan 1978 35440 Pennwalt Corporation (1975) Analytical Method for Residues of Endothall in Various Crops and Other Materials. Method dated May 1975. (Unpubli shed study received Jan 5, 1978 under 1F1105; CDL:096703 - Q) 05 -Jan 1978 35441 Pennwalt Corporation (19) Storage Stability of Endothall Residues. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - R) 05 -Jan 1978 35442 Pennwalt Corporation (1974) Results of Residue Determinations: Disappearance of Endothall in Water. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - S) 05 -Jan 1978 35444 Pennwalt Corporation (1975) Results of Residue Determinations: Residues in Irrigated Crop s. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - U) 05 -Jan 1978 35445 Pennwalt Corporation (1977) Results of Residue Determinations: Animals (Meat, Milk, and Eggs). (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - V) 05 - Jan 1978 35446 Pennwalt Corporation (1972) Metabolism and Fate of Endothall: Aquatic Environment (Water, Aquatic Plants, and Hydrosoil). (Unpublished study received Jan 5, 1978 under 1F1105; CDL: 096703 -W) 05 -Jan 1978 35447 Pennwalt Corporation (1960) Metabolism and Fate of Endothall: Fish. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - X) 05 -Jan 1978 35448 Pennwalt Corporation (1975) Metabolism and Fate of Endothall: Crops. (Unpublished study received Jan 5, 1978 under 1F1105; CDL: 096703 - Y) 05 -Jan 1978 35449 Pennwalt Corporation Metabolism and Fate of Endothall: Animals. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 -Z) 05 -Jan 1978 35450 Pennwalt Corporation Metabolism and Fate of Endothall: Soils. (Unpublishedstudy received Jan 5, 1978 under 1F1105; CDL:096703 - AA) 05 -Jan 1978 35451 Pennwalt Corporation (1976) A Further Characterization of 14C Activity Resulting in Goats Milk after Feeding 14C Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; C DL: 096703 - AB) 05 -Jan 1978 Smith, K.S. (1976) 14C- Endothall Feeding Study in Lactating Goats: Laboratory No. 6E 35452 2214. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem D iv., King of Prussia, Pa.; 05 -Jan 1978 CDL: 096703 - AC) 35453 Pennwalt Corporation (1954) Toxicology Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - AE) 05 -Jan 1978 35454 Pennwalt Corporation Analytical Method, Residues, and Metabolites. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - AF) 05 -Jan 1978 35455 Pennwalt Corporation Fate and Persistence in the Environment. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - AG) 05 -Jan 1978 35456 Pen nwalt Corporation (1952) Safety to Manufacturer, Applicator, and User. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - AH) 05 -Jan 1978 

### 7835457 Pennwalt Corporation (1963) Reasonable Grounds in Support of the Petition: Summary: Endothall. ( Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - AD) 05 -Jan 1978 Pennwalt Corporation (1976) Analytical Procedure for Aquathol(R) (Endothal Turf 35892 Herbicide and Endothal Weed Killer), Aquathol K, Herbicide 273 and Aquathol Granular. Me thod dated Apr, 1976. (Unpublished study received Jan 5, 1978 under 05 -Jan 1978 1F1105; CDL: 096703 - F) 36528 Pennwalt Corporation (1975) Environmental Chemistry: Conclusions. Summary of studies 096704 - B, 096704 - D through 096704- G, 096704 - L and 096704 - M. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096704 - A) 05 -Jan 1978 36529 Carlson, R.E.; Sandeno, J.L. (1970) Effect of Endothall on the Growth of Several Fungi. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp ., Agchem Div., King of Prussia, Pa.; CDL:096704 - B) 05 -Jan 1978 Watson, J.D.; Isensee, A.R. (1972) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method Used: (Endothall). 36538 (Unpublished study recei ved Jan 5, 1978 under 1F1105; prepared in cooperation with U.S. Agricultural Research Service, Plant Science Div., Crop Protection Research 05 -Jan 1978 Branch, Pesticide Investigations -- Behavior in Soils, submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704 - M) 36540 Pennwalt Corporation (1977) Human Safety: Summary of Toxicity Data. Summary of studies 096704 - D through 096704- J, 096704- M and 096704 - BV through 096704 - BY. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096707 - O) 05 -Jan 1978 36541 Latven, A.R. (1975) Endothall Technical (N.B. 58- 196- 2). (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704- Q) 05 -Jan 1978 Latven, A.R. (1975) Ripenthol N.B. 58- 188 - 3 (Isopropyl-butanol Formulation). 36547 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL :096704 - Y) 36548 Latven, A.R. (1975) Ripenthol N.B. 58- 191 - 2 (Water Only Formula -tion). (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-Z) 05 -Jan 1978 Stevens, K.R. (1976) Teratologic Evaluation of Endothal in Rats: Laboratory No. 5129. 36593 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Food and Drug Research Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, 05 -Jan 1978 Pa.; CDL:096704 - BV) Latven, A.R. (1975) Ripenthol N.B. 58- 191 - 2 (23.4%). (Unpublished study including 36597 letter dated Aug 14, 1975 from A.R. Latven to Obren Kechemet, received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 05 -Jan 1978 Agchem Div., King of Prussia, Pa.; CDL:096704 - CA) 37355 Walsh, G.E. (1970) Effects of Pesticides: Report No. 2 - 119a. (U.S. Fish and Wildlife Service, Bureau of Commercial Fisheries, un -published study; CDL:091902- R) 03 - Sep 1971 Brimhall, P.B. (1969) 1969 Herbicide Report. (Unpublished study including letter dated 37773 Dec 19, 1969 from P.B. Brimhall to Barry Regan, received May 1, 1971 under 1F1165; prepared by Northern Ohio Sugar Co., submitted by Dow Chemical U.S.A., Midland, 01 - May 1971 Mich.; CDL:090959- F) 38629 Surber, E.W.; Pickering, Q.H. (1962) Acute toxicity of Endothal, Diquat, Hyamine, Dalapon, and Silvex to fish. Progressive Fish - Culturist (Oct):164 - 171. (U .S. Public 01 -Jan 1962 

### 79Health Service, Robert A. Taft Sanitary Engineering Center, published study; 18 - MarCDL:095428 - F) 1976 Scott, R.A., Jr.; Gangstad, E.O. (1970) Technical Report of Monitoring Guidelines for Use-- Registration of Herbicides in Q uiescent Aquatic Sites: AD882977. Includes undated methods en -titled: Extraction of Butoxyethanol ester of 2,- 4D from water and analysis by gas chromatography; Extraction of 2,4- D acid, amines, and mineral salts from water and 38630 analysis by gas chromatograp hy; Extraction of Isooctyl and PGBE ester of Phenoxy acid herbicides from water and analysis by gas chromatography; Extraction of Dichlobenil 13 -Jun 1975 from water and analysis by gas chromatography; Analytical method for residues of Endothall in water. (Unpublished study received Jun 13, 1975 under 5E1648; prepared by U.S. Dept. of the Army, Office of the Chief of Engineers and Pennwalt Corp., submitted by Chevron Chemical Co., Richmond, Calif.; CDL:095428- H) Blackburn, R.D.; Gangstad, E.O. (1970) Efficacy and Residues of Diquat Applied for 38631 Control of Egeria and Hydrilla. (Unpublished study received Jun 13, 1975 under 5E1648; prepared by U.S. Agricultural Research Service, Florida/Antilles Area and others, 13 -Jun 1975 submitted by Chevron Chemical Co., Richmon d, Calif.; CDL:095428- I) Schreck, C.B.; Berry, C.R.; Strange, R.J.; et al. (1974) Ecosystem Studies on the Use of Diquat and Endothal for Aquatic Plant Con -trol in a Large Potable Water Supply 38643 Reservoir: Contract No. DAW - 65 - 74- C- 0013. (Virginia, Commission of Game and Inland Fisheries and Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Office of the Chief of Engineers, Aquatic 13 -Jun 1975 Plant Control Program, Interagency Technic al Advisory Committee, unpublished study; CDL:095428 - Y) Strange, R.J. (1975) The Effects of Herbicides on Primary Productivity, Phytoplankton 38644 Dynamics, and Water Chemistry of an Aquatic System. Master's thesis, Virginia Polytechnic Inst itute and State Univ. (Unpublished study received Jun 13, 1975 under 13 -Jun 1975 5E1648; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:095428 -Z) Van Horn, S.L. (1975) Dissipation of the Herbicides Endothall, Diquat, and a 1:1 Mixture 38645 in Water, Sediment, and Egeria densa. Master's thesis, Virginia Polytechnic Institute and State Univ. (Unpublished study received Jun 13, 1975 under 5E1648; submitted by 13 -Jun 1975 Chevron Chemical Co., Richmond, Calif.; CDL:095428- AA) MacEwen, J.D. (1963) Toxicity Studies on Endothal acid: Development File No. 342.44- 10 - Apr40960 11/1. (Unpublished study received Apr 10, 1966 under 6G0503; prepared by Wayne State Univ., Dept. of Industrial Medicine and Hygiene, submitted by Pennsalt Chemical Corp., 1966 14 - AprBryan, Tex.; C DL:090587- C) 1966 40962 Brieger, H. (1953) Endothal Short - Term Oral Toxicity Test: Dogs. (Unpublished study received Apr 10, 1966 under 6G0503; prepared by Jefferson Medical College, submitted by Pennsalt Chemical Corp., Bryan, Tex.; C DL:090587 - E) 10 - Apr1966 14 - Apr1966 40966 Pennsalt Chemical Corporation (19) Residue Studies on Cotton -seed. (Unpublished study received Apr 10, 1966 under 6G0503; CDL:090587- I) 10 - Apr1966 40971 Lee, W.M.; Munter, P.A. (1953) Endothal -- Residue Analy sis -- Progress Report. (Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587- O) 10 - Apr1966 40972 Lee, W.M.; Lyons, H. (1953) Endothal -- Residue Analysis -- Progress Report. (Unpublished study re ceived Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex., CDL:090587- P) 10 - Apr1966 40973 Massengale, J.T. (1952) Bioassay of Endothal Residues. (Unpublished study received 10 - Apr

### 80Apr 10, 1966 under 6G0505; submitted by Pennsalt Chemi cal Corp., Bryan, Tex.; 1966 CDL:090587 - Q) Carlson, R.E. (1966) Bioassy of Endothal. Undated method. (Unpublished study received 10 - Apr- 40975 Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex., 1966 CDL:090587 - S) Munter, P.A. (1954) Determination of Endothal Residues in Plant Material. Undated 40976 method. (Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt 10 - Apr1966 Chemical Corp., Bryan, Tex.; CDL:090587- T) 14 - Feb Montgomery, M.; Freed, V.H . (1961) The Absorption and Metabolism of Endothal when 1961 Used as a Post - emergence Treatment for Beets --Progress Report. (Unpublished study 08 -Jul - 40977 received Apr 10, 1966 under 6G0503; prepared by Oregon State Univ., Agricultural 1965 Chemistry Dept., submitted by Pennsa lt Chemical Corp., Bryan, Tex.; CDL:090587- U) 10 - Apr1966 15 - Dec 1964 21 -Jan 1965 08 -Jul 1965 Montgomery, M.L.; Freed, V.H. (1964) Endothal. (Unpublished study received Apr 10, 40981 1966 under 6G0503; prepared by Oregon State Univ., Dept. of Agricultural Chemistry, 15 - Mar1966 submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587 - Y)

Oregon State University (19) Preliminary Study on Microbial Effect on Endothal. 40982 (Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587- Z) 10 - Apr1966 15 - Feb 1967 15 - Apr1970 10 - Apr1966 15 - Feb 1967 01 - Dec 1970 40985 Bowles, E.J.; Carlson, R.E. (1964) Endothall Analysis. (Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587 - AC) 10 - Apr1966 Anon. (1967) 1967 Pennsylvania Guide, Chemical Weed Control for Vegetable Crops: 41271 Selection, Application, Safety. University Park, Pa.: Pennsylvania State Univ., Extension Service. (Incomplete; also in unpublished submission received Oct 2, 1967 under 02 - Oct 1967 8F0643; submitted by Stauffer Chemical Co., Westport, Conn.; CDL:091116- AI) 42579 Pennwalt Corporation (1973) Hydrothol 191 Rice Herbicide Summary --Research Fie ld Tests. (Unpublished study received Jul 10, 1975 under 4581 - 18; CDL:243210 - A) 10 -Jul 1975 44465 Burkhalter, A.P. (1972) Guidelines for Aquatic Weed Control. Rev. By Florida, Dept. of Natural Resources, Bureau of Aquatic Plant Research and Control. Tall ahasee, Fla.: Florida, DNR. (Published study; CDL:022791 - A) 24 - May 1974 Swabey, Y.H.; Schenk, C.F. (1963) Report on Algicides and Aquatic Herbicides. 12 -Jan 46269 (Ontario, Water Resources Commission, Laboratory Division, Biology Branch, 1965 unpublished study; CDL: 107773 - B) 14 - Apr

### 811966 Fink, R. (1975) Final Report: Eight - Day Dietary LC50 - Bobwhite Quail: Project No. 110 ­ 52229 105. (Unpublished study received Oct 21, 1975 under 4581 - EX - 18; prepared by Truslow Farms, Inc., submitted by Pennwalt Corp., Agc hem Div., King of Prussia, Pa.; CDL: 21 - Oct 1975 096340 - A) Silvo, O.E.J. (1967) Alustavia Tutkimuksia Eraiden Herbisidien Myrkyllisyydesta 55714 Nuorille Karpin Poikasille (Cyprinus carpio L.). N.P. (Suomen Kalatalous 32 Finlands Fiskerier; incomplete; also in unpublished submission received Jul 11, 1961 under 11 -Jul 1961 1E1046; submitted by U.S. Dept. of the Army, Washington, D.C.; CDL:093359 - X) 57411 Keckemet, O. (1974) Letter sent to Charlotte M. Young dated Feb 25, 1974 Efficacy studies on rice. (U npublished study received May 1, 1974 under 4F1499; submitted by Uniroyal Chemical, Bethany, Conn.; CDL:094551 - D) 01 - May 1974 58568 Pennwalt Corporation (19) Endothall Technical. Tacoma, Wash.: Pennwalt. (Product data bulletin no. 13c; also in unpublishe d submission received Feb 1, 1975 under 3F1416; CDL:093785 - D) 01 - Feb 1975 58575 Pennwalt Corporation (1973) Analytical Method for Residues of Endothall in Various Crops and Other Materials. Method dated May 1973. (Unpublished study received Feb 1, 1975 u nder 3F1416; CDL:093785 - N) 01 - Feb 1975 58722 Latven, A.R. (1977) Toxicology Report for ...: Endothall acid # 3441. (Unpublished study received Oct 26, 1978 under 4581 - 282; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia , Pa.; CDL:235435 - D) 26 - Oct 1978 Brieger, H. (19) Results of Sub - acute Feeding Tests with Endothal. (Unpublished study 61096 received on unknown date under unknown admin. no.; prepared by Jefferson Medical College, Div. of Industrial Medicine, submitted by ; CDL:109899- A) Anon. (1966) Summary of Toxicity Studies with Endothal Formulations on Animals. 61097 (Unpublished study received on unknown date under unknown admin. no.; submitted by ; CDL:109890 - A) 61605 Anon. (1967) Acute Oral LD50 Data for Aquatic Herbicides. (Unpublished study received Nov 18, 1968 under unknown admin. no.; ; CDL:109792- A) 18 - Nov 1968 Simsiman, G.V.; Daniel, T.C.; Chesters, G. (1976) Diquat and endothall: Their fates in 65605 the environment. Residue Reviews 62:131 -174. (Also in unpublished submission received Aug 22, 1977 under 239- 1663; submitted by Chevron Chemical Co., Richmond, 22 - Aug 1977 Calif.; CDL:231430 - E) Schreck, C.B. (1974) Aquatic Plant Control Using Herbicides in a Large Potable Water 67174 Supply Reservo ir: Contract No. DACW65 - 74 -C- 0013. (Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, 22 - Aug 1977 Corps of Engineers; unpublished study; CDL:231433 - D) 67723 Pennsalt Chemical Corporation(1967) Chemical Data Regarding Des - i - cate. (Compilation; unpublished study received May 8, 1967 under 7G0608; CDL:092900- A) 08 - May 1967 67762 Pennwalt Corporation (1970) Chemical Data Regarding Endothall. (Unpublished study received Feb 1, 1975 under 45 81 - EX - 21; CDL: 094575 - A) 01 - Feb 1975 67763 Keckemet, O. (1975) Reasonable Grounds in Support of the Petition for Residue Tolerance: Endothall. (Unpublished study received Feb 1, 1975 under 4581 - EX - 21; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:0 94575 - F) 01 - Feb 1975 69050 Pennwalt Corporation (1979) Human Safety: Summary of Toxicity Data. Summary of 23 -Jan 

### 82studies 099882 - C and 099882- E through 099882 -I. (Unpublished study received Jan 23, 1981 1981 under 1F1105; CDL: 099882 - B) Knickerbo cker, M.; Becci, P.J. (1980) Teratologic Evaluation of Endothall in Rats: 69051 Laboratory No. 5129. (Unpublished study, including letters dated Dec 31, 1980 from C.H. Williams to Obren Keckemet and Jan 7, 1981 from R.A. Parent to Bernalyn McGaughey, received Jan 23, 1981 under 1F1105; prepared by Food and Drug Research 23 -Jan 1981 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099882 - C) Curren, R.D.; Schechtman, L.M.; Parmar, A.S.; et al. (1980) Activity of T1604 in the 69054 Salmonell a/Microsomal Assay for Bacterial Mutagenicity: Study No. T1064.102. Final report. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Microbiological Associates, submitted by Pennwalt Corp., Philadelphia, Pa.; 23 -Jan 1981 CDL:099882 - G) Schechtman, L.M.; Beard, S.F.; Sinsky, P.M. (1980) Activity of T1604 in the in vitro 690 55 Mammalian Cell Point Mutation Assay in the Absence of Exogenous Metabolic Activation: Study No. T1604.106. Final report. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Microbiological Associates, submitted by Pennwalt Corp., 23 -Jan 1981 Philadelphia, Pa.; CDL:099882 - H) Schechtman, L.M.; Beard, S.F.; Sinsky, P.M. (1980) Activity of T1604 in the in vitro 69056 Mammalian Cell Point Mutation Assay in th e Presence of Exogenous Metabolic Activation: Study No. T1604.107. Final report. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Microbiological Associates, submitted by Pennwalt Corp., 23 -Jan 1981 Philadelphia, Pa.; CDL:099882 - I) Rodwell, D.E.; Spencer, A.G.; Allen, S.; et al. (1980) Range -finding Study in Non - 23 -Jan 69057 pregnant Female Mice: IRDC No. 470 - 004. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by International Research and Development Corp., submitted by 1981 29 -Jan Pennwalt Corp., Philadelphia, Pa.; CDL:099882 - J) 1981 Bond, C.E.; Lewis, R.H.; Fryer, J.L. (1960) Toxicity of various herbicidal materials to 18 - Mar69192 fishes. Pages 96 - 101, In Transactions of the 1959 Seminar of Biological Problems in Water Po llution. By Robert A. Taft Engineering Center. Cincinnati, Ohio: U.S. Public 1976 26 - AprHealth Service. (Technical report W60- 3; published study; CDL:230691 - H) 1977 71130 Pennwalt Corporation (1979) Fish and Wildlife Safety Summary. Summary of st udies 244131 - B through 222131 - R. (Unpublished study received Jan 23, 1981 under 4581 - 174; CDL:244131 - A) 23 -Jan 1981 Bodden, R.M. (1979) Avian Single - dose Oral LD50: Study No. W - 910. (Unpublished 71131 study, including letter dated Jul 8, 1980 from R.M. B odden to Obren Keckemet, received Jan 23, 1981 under 4581 -174; prepared by Ralston Purina Co., submitted by Pennwalt 23 -Jan 1981 Corp., Philadelphia, Pa.; CDL:244131 - B) Vilkas, A.G.; Hughes, J.S. (1979) The Acute Toxicity of Endothall to the Water Flea 71137 Daphnia magna Straus: UCES Project No. 11506-41 - 09. (Unpublished study received Jan 23, 1981 under 4581 - 174; prepared by Union Carbide Corp., submitted by Pennwalt 23 -Jan 1981 Corp., Philadelphia, Pa.; CDL:244131 - I) Vilkas, A.G.; Seminara, J . (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 71142 Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 11506 - 41 - 11. (Un -published study received Jan 23, 1981 under 4581 - 174; prepared by 23 -Jan 1981 Union Carbide Corp., submit ted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - O) 71143 Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) Technical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506 - 41 - 12. (Unpublished study received Jan 23, 1981 23 -Jan 1981 

### 83under 4581 - 174; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - P) Bailey, H.C. (1980) Letter sent to Bernalyn D. McGaughey dated Sep 19, 1980 71145 (Summary of results of 48 -hour mussel embryo bio - assay performed on Endothall): SRI Project LSC- 1514- 6. (Unpublished study, including letter dated Jun 20, 1980 from H.C. Bailey to Bernalyn D. McGaughey, received Jan 23, 1981 under 4581 - 174; prepared by 23 -Jan 1981 SRI International, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - R) 71446 Pennwalt Corporation (1981) Human Safety: Introduction. (Unpublished study received Mar 25, 1981 under 4581 - 223; CDL:099955 - D) 25 - Mar1981 Bodden, M.R. (1979) Avian Single - dose Oral LD50: Study No. W - 910. Final report. 72455 (Unpublished study, including letter dated Jul 8, 1980 from R.M. Bodden to Obren Keckemet, received Jan 23, 1981 under 1F1105; prepared by Ralston Purina Co., 23 -Jan 1981 submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - B) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 72464 Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 11506 - 41 - 11. ( Unpublished study received Jan 23, 1981 under 1F1105; prepared by 23 -Jan 1981 Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - O) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 72465 Te chnical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11056- 41 - 12. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt Corp., 23 -Jan 1981 Philadelphia, Pa.; CD L:099883 - P) 72467 U.S. Department of Interior, Bureau of Reclamation (1964) Results of Algaecidal Evaluation Tests of Selected Compounds: Report No. WC - 21. Annual progress report. of 1964, laboratory studies. (Unpublished study; CDL:099883 - U) 23 -Jan 1981 73305 Keckemet, O. (1973) Reasonable Grounds in Support of the Petition: Endothall. (Unpublished study, including published data, received Feb 1, 1975 under 3F1416; submitted by Pennwalt Corp., Tacoma, Wash.; CDL:093785 - H) 01 - Feb 1975 73337 Pennwalt Corporation (1977) Human Safety: Summary of Toxicity Data. Summary of studies 235435 - B through 235435 - E. (Unpublished study received Oct 26, 1978 under 4581 - 282; CDL:235435 - A) 26 - Oct 1978 Rodwell, D.E.; Goldenthal, E.I.; Blair, M.; et al . (1980) Teratology Study in Mice: Study 73371 No. 470 - 006. (Unpublished study received Jan 23, 1981 under 4581 - 174; prepared by International Research and Development Corp., submitted by Pennwalt Corp., 23 -Jan 1981 Philadelphia, Pa.; CDL:244123 - J) Oborn , E.T.; Bartley, T.R. (1954) Tolerance of Crops to Herbicides in Irrigation Water: 73854 Laboratory Report No. SI - 3. (U.S. Agricultural Research Service, Field Crops Research Branch and U.S. Dept. of the Interior, Bureau of Reclamation, Office of the Assistant Commissioner and Chief Engineer, Engineering Laboratories; unpublished study; 03 - Mar1971 CDL:090913 - I) 74220 Bodden, R.M. (1979) Avian Single - dose Oral LD50. (Unpublished study received Jan 23, 1981 under 4581 - 282; prepared by Ralston Purina Co., submitt ed by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - B) 23 -Jan 1981 Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 74224 Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 11506 - 41 - 11 . (Unpublished study received Jan 23, 1981 under 4581 - 282; pre -pared by 23 -Jan 1981 Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - O) 

### 84Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Endothall (Acid Monohydr ate) 74225 Technical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506- 41 - 12. (Unpublished study received Jan 23, 1981 under 4581 - 282; prepared by Union Carbide Corp., submitted by Pennwalt Corp., 23 -Jan 1981 Philadelphia , Pa.; CDL:244122 - P) Bailey, H.C. (1980) Letter sent to Bernalyn D. McGaughey dated Sep 19, 1980 Results of 74227 48 -hour mussel embryo bioassay performed on Endothal: SRI Project LSC- 1514- 6. (Unpublished study received Jan 23, 1981 under 458 1 - 282; prepared by SRI 23 -Jan 1981 International, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - R) 74228 Pennwalt Corporation (19) Toxicity Testing Protocols: Mussel Embryo Test. (Unpublished study received Jan 23, 1981 under 4581 - 282; CDL:2 44122 - S) 23 -Jan 1981 75236 Brieger, H. (1950) Preliminary Toxicity Studies on Endothal. (Jefferson Medical College, Div. of Industrial Medicine for U.S. Food and Drug Administration; unpublished study; CDL: 109911 - A) 21 - Mar1951 Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology 78180 reports on seven products. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 05 -Jan 1978 Pa.; CDL:232580 - B) Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Endothall 78181 Technical (N.B. 58 - 196- 2). (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphi a, 05 -Jan 1978 Pa.; CDL:232580 - C) Stevens, K.R. (1976) Teratologic Evaluation of Endothall in Rats: Laboratory No. 5129. 78611 (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Food and Drug Research Laboratories, Inc., submitted by Pen nwalt Corp., Philadelphia, Pa.; CDL: 05 -Jan 1978 232580 - BI) Sikka, H.C.; Saxena, J. (1973) Metabolism of endothall by aquatic microorganisms. 79977 Journal of Agricultural and Food Chemistry 21 (3):402- 406. (Also in unpublished submission received Feb 1, 1975 under 4581 - EX - 21; submitted by Pennwalt Corp., 01 - Feb 1975 Philadelphia, Pa.; CDL:094575 - G) 80437 Pennsalt Chemicals Corporation (1954) Full Reports of Investigations Made with Respect to the Safety of the Product. (Unpublished study received Feb 4 , 1966 under 6G0503; CDL:090585 - B) 04 - Feb 1966 10 -Jun 1966 Montgomery, M.L.; Freed, V.H. (1964) Preliminary Study on Microbial Effect on 80439 Endothal. (Unpublished study received Feb 4, 1966 under 6G0503; prepared by Oregon State Univ., Dept. of Agricu ltural Chemistry, submitted by Pennsalt Chemicals Corp., 04 - Feb 1966 Tacoma, Wash.; CDL:090585 - D) 81397 Pennwalt Corporation (1966) Toxicological Investigations, Mammals: Summary. Summary of studies 051133 - B through 051133 - M and 051133 - R. (Unpublished st udy received Apr 14, 1966 under 4581 - 70; CDL:051133 - A) 14 - Apr1966 15 - Dec Keller, J.G.; Platt, W.R.; Steingruby, P.B. (1964) Final Report on Three - week Repeated 1964 81400 Dermal Application of Herbicide 282 to Albino Rabbits: S.A. No. 95431. (Unpublished study rec eived Apr 14, 1966 under 4581 - 70; prepared by Scientific Associates, Inc., 14 - Apr1966 submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 051133 - D) 10 -Jun 1966 

### 8581403 U.S. Agricultural Research Service (1954) Toxicity of Endothal to Sheep. ( Field Crops Research Branch, Irrigation Experiment Station, Weed Investigation Section; unpublished study; CDL: 051133 - G) 14 - Apr1966 10 - Jun 1966 81404 Brieger, H. (1953) Endothal: Long - term Oral Toxicity Test. (Unpublished study received Apr 14, 1966 un der 4581 - 70; prepared by Jefferson Medical College, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:051133 - H) 14 - Apr1966 10 - Jun 1966 Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate), 83026 89.5% Acid Equivalent, t o the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506 - 41 - 10. (Unpublished study received Jan 23, 1981 under 4581 - 174; prepared by 23 -Jan 1981 Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - L) 83032 Pennwalt Corpor ation (1979) Fish and Wildlife Safety: Summary. (Unpublished study received Mar 25, 1981 under 4581 - 223; CDL: 244664- A) 25 - Mar1981 25 - Mar83033 Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 244662 - B. (Unpublished study receivedMar 25, 1981 under 4581 - 223; CDL:244662 - A) 1981 14 - Sep 1981 Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate), 83108 89.5% Acid Equivalent, to the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506 - 41 - 10. ( Unpublished study received Jan 23, 1981 under 1F1105; prepared by 23 -Jan 1981 Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - L) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate), 84151 8 9.5% Acid Equivalent, to the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506 - 41 - 10. (Unpublished study received Jan 23, 1981 under 4581 - 282; prepared by 23 -Jan 1981 Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - L) 84382 Seaman, D.E.; Berkenkotter, P.; Chen, T.M.; et al. (1966) Persistence of Residues and Fates of Herbicides in Rice Fields and in Rice - field Effluents: Progress report WRC Project No. W 3 02 67. for the period Mar 1, 1965 to Jan 31, 1966. (Unpublishe d study received Oct 8, 1981 under 476 - 2107; prepared by Univ. of California -- Davis, Dept. of Botany, submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:246011 - M) 08 - Oct 1981 14 - Oct 1983 Carlson, R.; Whitaker, R.; Landskov, A. (1978) Endothall. Pages 327 - 340, In Analytical 84602 Methods for Pesticides and Plant Growth Regulators. New York, N.Y.: Academic Press, Inc. (also in unpublished submission received Sep 14, 1981 under 4581 - 349; submitted 14 - Sep 1981 by Pennwalt Corp., Philadelphia, Pa.; CDL:246016- B) 84603 Pennwalt Corporation (1951) Human Safety: Summary of Toxicity Data. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL:246012 - A) 14 - Sep 1981 84604 Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012- J through 246012- P. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL:246012 - B) 14 - Sep 1981 84606 Pennwalt Corporation (1979) Teratology: Endothall. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL:246012 - D) 14 - Sep 1981 84607 Pe nnwalt Corporation Metabolism Studies: Endothall. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL: 246012 - E) 14 - Sep 1981 84611 Pennwalt Corporation (1972) Mutagenicity Studies: Endothall. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL: 246012 - I) 14 - Sep 1981 

### 8684613 Ralston Purina Company (1981) Endothal Granular Turf Herbicide: RT Lab No. 867431. (Unpublished study received Sep 14, 1981 under 4581 - 349; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 246012 - O) 14 - Sep 1981 Blair, M.; Nemec, M.D.; Bajo, C.; et al. (1981) Teratology Study in Mice: 470 - 006. 02 -Jul 85940 (Unpublished study received Sep 3, 1981 under 1F1105; prepared by International Research and Development Corp., submitted by Pennwalt Corp., Tacoma, Wash.; CDL: 1981 03 - Sep 07027 7 - A; 070276) 1981 86622 Scribner, J.D. (1981) Evaluation of Studies on Genetic Toxicity of Endothall. (Unpublished study received Jul 29, 1981 under 4581 - 204; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:245680 - D) 29 -Jul 1981 86623 Pennwalt Corporation (1981) Endothall Teratology Study in Mice. (Unpublished study received Nov 12, 1981 under 1F1105; CDL: 070448 - A) 12 - Nov 1981 88988 Bowmer, W.J. (1981) Letter sent to Richard F. Mountfort dated Dec 14, 1981 Information on residu e and deposition of drift data. (Texas, Dept. of Agriculture, Agricultural & Environmental Sciences Div.; unpublished study; CDL:246530 - A) 28 - Dec 1981 88989 Landskov, A. O. (1981) Letter sent to Letha Coenen dated Nov 25, 1981: Residues of endothall on c otton seed. (Unpublished study received Dec 28, 1981 under TX 81/47; prepared by Pennwalt Corp., submitted by state of Texas, Austin, Tex.; CDL:246531 - B) 28 - Dec 1981 90431 Anon. (1954) Toxicity of Endothal to Sheep. (Unpublished study received on unknown date under unknown admin. no.; CDL:109906 - A) Fang, S.C.; Tinsley, I. (1967) Metabolism of C14I - labeled Disodium 3,6 - 96294 Endoxohexahydrophthalate (Endothall) in Rats. Final report. (Unpublished study, including letter dated Oct 14, 1966 from R.E. Carlson to D.M. Baker, Jr., received Feb 17, 1967 under 7F0570; prepared by Oregon State Univ., Dept. of Agricultural 17 - Feb 1967 Chemistry, submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719- E) 96299 Menzie, C.M. (1964) Letter sent to H.L. Lind aberry dated Oct 15, 1964 Toxicity to mallards. (U.S. Fish and Wildlife Service, Patuxent Wildlife Research Center, Section of Chemical and Physiological Studies; unpublished study; CDL:090719 - K) 23 - Mar1967 Peoples, S.A. (1965) The Excretion of C1 4 Tagged Endothall in the Rat. (Unpublished 96300 study received Feb 17, 1967 under 7F0570; prepared by Univ. of California -- Davis, Dept. of Physical Sciences, submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL: 17 - Feb 1967 090719- L) Maestri, M. (1967) Structural and Functional Effects of Endothall on Plants. 17 - Feb 96302 (Unpublished study, including letter dated Nov 3, 1966 from H.B. Currier to Edward J. Bowles, received Feb 17, 1967 under 7F0570; prepared by Univ. of California -- Davis, 1967 15 - AprDept. of Botany, submitt ed by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719- R) 1970 97377 Tischler, N.; Bates, J.C.; Quimba, G.P. (1949) A New Group of Defoliant -herbicidal Chemicals. (Unpublished study received Dec 5, 1949 under unknown admin. no.; submi tted by Sharples Chemical, Inc., Philadelphia, Pa.; CDL:109908 - A) 05 - Dec 1949 97424 Carlson, R.E. (1977) Letter sent to Obren Keckemet dated Oct 25, 1977: Effect of yeast culture on endothall. (Unpublished study received Jan 5, 1978 under 1F1105; submitt ed by Pennwalt Corp., Philadelphia, Pa.; CDL:096704 - E) 05 -Jan 1978 Applied Biochemists, Incorporated Nomenclature, Chemical and Physical Properties of 99327 Endothal Technical (Acid) and Cutrine, a Copper Triethanolamine Complex. (Compilation; un -publis hed study received Dec 21, 1972 under unknown admin. no.; 21 - Dec 1972 CDL:127670 - A) 

### 87Schreck, C.; Corning, R.; Berry, C.; et al. (1974) Aquatic Plant Control Using Herbicides 100609 in a Large Potable Water Supply Reservoir. Annual report, Jul 1, 1973 -- Ju n 30, 1974: Contract No. DACW65 - 74 - C - 0013. (Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Corps of Engineers; 02 - Dec 1974 unpublished study; CDL:247354- B) Silvo, O. (1967) Alus tavia Tutkimuksia Eraiden Herbisidien Myrkyllisyydesta Nuorille 102855 Karpin Poikasille (Cyprinus catpio L.). Helsinki, Fin.: species name. (Suomen Kalatalous 32; also in unpublished submission received Feb 3, 1976 under 960- 163; sub -mitted by 03 - Feb 1976 Balcom Chemicals, Inc., Greeley, CO; CDL:228944 - V) Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, 108102 Including a Description of the Analytical Methods Used: (Endothall). (Unpublished study received Feb 1, 1975 under 4G1449; s ubmitted by Pennwalt Corp., Tacoma, WA; CDL: 01 - Feb 1975 093861 - A) Moffett, J.; Morton, H.; MacDonald, R. (1972) Toxicity of some herbicidal sprays to 26 - Sep 111488 honey bees. Journal of Economic Entomology 65(1):32 - 36. (Also In unpublished submission receivedSep 26, 1974 under 464 - 323; submitted by Dow Chemical U.S.A., 1974 15 - Dec Midland, MI; CDL:120345 - H) 1983 113925 Agchem (1959) Environmental Studies on Endothal. (Compilation; unpublished study received Dec 3, 1959 under 4581 - 139; CDL: 007440 - A) 03 - Dec 1959 113927 Agchem (1966) Description of Analytical Methods and Results of Analyses for Dimethylcocoamine Endothall (Accelerate) in Cotton -seed. (Compilation; unpublished study received Feb 14, 1966 under 4581 - 284; CDL:007456 - A) 14 - Feb 1966 Kennedy, G. (1970) Report to Pennwalt Corporation: Distribution of 14C - Endothall in 113928 the Goat: IBT No. E8392. (Unpublished study received Dec 15, 1970 under 0F0972; prepared by Industrial Bio - Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, 15 - Dec 1970 WA; CDL:091670- A) Kennedy, G. (1970) Report to Pennwalt Corporation: Characterization of 14C in Milk 113929 and Urine of Goats Following Oral Administration of 14C - Endothall: IBT No. E8392. (Unpublished study received Dec 15, 1970 under 0F0972; prepared by Industrial Bio - Test 15 - Dec 1970 Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:091670 - B) Kennedy, G.; Jenkins, D. (1970) Report to Pennwalt Corporation: Tissue Residue Study 113930 with 14C Labeled Endothall in Pre - condi tioned and Naive White Leghorn Chickens: IBT No. J8352. (Unpublished study received Dec 15, 1970 under 0F0972; prepared by Industrial Bio - Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; 15 - Dec 1970 CDL:091670 - C) 113934 Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the Product: Endothall. (Unpublished study received Dec 1, 1970 under 1F1105; submitted by Pennwalt Corp., Tacoma, WA; CDL:094510- A) 01 - Dec 1970 113935 Pennwalt Corp. (1970) Name, Chemica l Identity and Composition of Endothall. (Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094508- A) 01 - Dec 1970 113936 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. (Compilation; unpublished study recei ved Dec 1, 1970 under 1F1105; CDL:094507- A) 01 - Dec 1970 113937 Pennwalt Corp. (1970) Study: Hydrothol Efficacy. (Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL: 094507- B) 01 - Dec 1970 113938 Pennwalt Corp. (1972) Toxicity Study: E ndothall on Rats & Fish. Summary of studies 094506- C and 094506 - D. (Unpublished study received May 31, 1972 under 1F1105; CDL:094506 - B) 31 - May 1972 

### 88113952 Walsh, G. (1971) Effects of Herbicides on Photosynthesis and Growth of Marine Unicellular Algae. (E nvironmental Protection Agency, Gulf Breeze Laboratory; unpublished study; CDL:094506- F) 13 - May 1972 28 - Apr113953 Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method Used: Endothall. ( Compilation; unpublished study received May 13, 1972 under 1F1105; CDL:094506- H) 1972 04 - May 1972 13 - May 1972 Pennwalt Corp. (1971) A Report of Two Studies on Residues in Potatoes and Soil after 113954 Treatment with Endothall and 14C Endothall Fo rmulated as DES -I- CATE. (Compilation; unpublished study received on unknown date under 1F1057; CDL:093370 - A) 113957 Pennwalt Corp. (1971) Name, Chemical Identity and Composition of Pesticide Chemical: Endothall. (Compilation; unpublished study receivedJan 20, 1971 under 1F1057; CDL:093370 - E) 20 -Jan 1971 113959 Watson, J. (1971) Full Reports of Investigations Made with Respect to the Safety of the Product: Endothall. (Unpublished study received Aug 11, 1971 under 1F1057; submitted by Pennwalt Corp., T acoma, WA; CDL:091892- A) 11 - Aug 1971 113961 Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of the Product: Endothall. Summary of studies 091673 - B through 091673 - E. (Compilation; unpublished study received Apr 7, 1970 under 0F0972; CDL:091673 - A) 07 - Apr1970 07 - Apr113964 Pennwalt Corp. (1968) Study: 14C Endothall Residue in Specified Products. (Compilation; unpublished study received Apr 7, 1970 under 0F0972; CDL:091673 - D) 1970 15 - Apr1970 113970 Pennwalt Corp. (19 63) Uptake, Distribution and Metabolism of Endothall in Blue Gills. (Unpublished study received May 1, 1974 under 4G1510; CDL:094010- D) 01 - May 1974 113971 Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of the Product : Endothall. (Compilation; unpublished study received on unknown date under 1F1105; CDL:094509 - A) 03 - May 1971 08 -Jul 113974 Oregon State Univ. (1962) Progress Report on the Endothal Project. Progress report no. 2. (Unpublished study received Jul 8, 1965 under 4 581 - 232; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:121844- B) 1965 01 - Dec 1970 14 - Nov 1984 Montgomery, M. (1962) Letter sent to O. Keckemet dated Oct 16, 1962 Endothal in soil. 113975 Progress report. no. 3. (Unpublished study received Jul 8, 1965 under 4581 - 232; prepared by Oregon State Univ., Dept. of Agricultural Chemistry, Agricultural Experiment Station, 08 -Jul 1965 submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:121844- C) 08 -Jul Comes, R.; Bohmont, D.; A lley, H. (1961) Movement and persistence of endothal as 1965 113977 influenced by soil texture, temperature, and moisture levels. Journal of the A.S.S.B.T. XI(4):287 - 293. (Also In unpublished submission received Jul 8, 1965 under 4581 - 232; 01 - Dec 1970 submitted by Agchem Div., P ennwalt Corp., Philadelphia, PA; CDL:121844- L) 14 - Nov 1984 113978 Agchem Movement and Persistence of Endothal under Controlled Conditions. 08 -Jul 

### 89(Unpublished study received Jul 8, 1965 under 4581 -232; CDL:121844- M) 1965 113979 Temby, F. (1963) Biological Breakdown of Endothal Compounds. (Unpublished study received Jul 8, 1965 under 4581 - 232; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL: 121844 - N) 08 -Jul 1965 113980 Temby, F. (1963) Soil Movement Studies wit h Endothal Compounds. (Unpublished study received Jul 8, 1965 under 4581 - 232; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL: 121844 - O) 08 -Jul 1965 113981 Temby, F. (1963) Soil Adsorption Studies -- Endothal Compounds. (Un -published study received Jul 8, 1965 under 4581 - 232; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:121844- P) 08 -Jul 1965 113982 Hiltibran, R. Duration of toxicity of endothal in water. Source unknown. (Also In unpublished submission received Jul 8, 1 965 under 4581 - 232; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:121844- Q) 08 -Jul 1965 15 - May 1966 Freed, V.; Montgomery, M.; Fang, S. (1958) The Absorption and Translocation of C14 08 - Sep 113986 Labeled Endothal in Red Beets and Spinach. (Un published study received Sep 8, 1958 under unknown admin. no.; prepared by Pennsylvania Salt Mfg. Co. of Washington, 1958 08 - Jul submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL: 124421 - A) 1965 113987 Agchem (1970) The Results of Te sts on the Amount of Residue Remaining Including a Description of the Analytical Method Used: Endothall. (Compilation; unpublished study received Jun 27, 1971 under unknown admin. no.; CDL:124882 - A) 27 -Jun 1971 113988 Medical Products (1970) Residue Section: (Endothall). (Unpublished study received on unknown date under 7182- EX - 8G; CDL:125806 - A) 114487 Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and Complete Composition of the Product: Endothall. (Compilation; unpu blished study received Jul 9, 1975 under 1F1105; CDL:094700 - A) 09 -Jul 1975 114488 Pennwalt Corp. (1975) Full Reports and Data of Investigations Made on the Safety of the Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study r eceived Jul 9, 1975 under 1F1105; CDL:094702- A) 09 -Jul 1975 114492 Pennwalt Corp. (1972) Responses of Plankton and Macrofauna Communities To Test Application of Chemical Herbicides. (Unpublished study received Jul 9, 1975 under 1F1105; CDL:094702 - H) 09 -Jul 1975 Schreck, C. (1974) Aquatic Plant Control Using Herbicides in a Large Potable Water 114495 Supply Reservoir: Contract No. DACW65 - 74 - C-0013. Annual report. Jul 1, 1973 - Jun 30, 1974. (Virginia Polytechnic Institute and State Univ., Dept. of Fisheri es and Wildlife Sciences for U.S. Dept. of the Army, Corps of Engineers; unpublished study; 09 -Jul 1975 CDL:094702 - L) 114500 Pennwalt Corp. (1975) Toxicity: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094706 - B) 09 -Jul 1975 114502 Pennwalt Corp. (1972) Biomagnification: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL: 094706- D) 09 -Jul 1975 114503 Pennwalt Corp. (1975) Metabolism: Endothall. (Unpublished study received Jul 9, 1975 u nder 1F1105; CDL:094706- E) 09 -Jul 1975 114504 Pennwalt Corp. (1975) Duration of Biological Activity: Endothall. (Unpublished study received Jul 9, 1975 under 1F1105; CDL: 094706- F) 09 -Jul 1975 

### 90114505 Agchem (1954) Toxicological Investigations -- Mammals: Endothall. (Unpublished study received Mar 15, 1966 under 4581 - 139; CDL: 007441 - A) 15 - Mar1966 114518 Agchem Residue Analytical Methods: Endothal. (Unpublished study received Mar 15, 1966 under 4581 - 139; CDL:007441 - S) 15 - Mar1966 114519 Oregon State Univ. Preliminary Study on Microbial Effect on Endothal. (Unpublished study received Mar 15, 1966 under 4581 -139; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:0074419 - V) 08 -Jul 1965 15 - Mar1966 Lewandowski, T. (1953) Letter se nt to P. Munter dated Aug 20, 1953: Microbiological 114520 examination of Endothal. (Unpublished study received Mar 15, 1966 under 4581 - 139; prepared by Pennsylvania Salt Mfg. Co., submitted by Agchem Div., Pennwalt Corp., 15 - Mar1966 Philadelphia, PA; CDL:007441 -W) 114521 Freed, V.; Montgomery, M. (1963) Progress Report on the Study of the Degradation Products of Endothal in Soil. (Unpublished study received Mar 15, 1966 under 4581 - 139; prepared by Oregon State Univ., Agricultural Experiment Station, Dept., of Agricultural Chemistry, submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:007441 - X) 08 -Jul 1965 15 - Mar1966 114523 Agchem (1961) Chemical Study: Endothal. (Compilation; unpublished study received Mar 15, 1966 under 4581 - 139; CDL: 007441 - AB) 15 - Mar1966 114531 Agchem (1972) Toxicity of Endothall in Animals. Summary of studies 095336 - H, 094506- C and 094506 - D. (Unpublished study received May 4, 1972 under 4581 - 284; CDL:095336 - C) 04 - May 1972 114534 Food and Drug Research Laboratories, Inc. ( 1976) Teratologic Evaluation -- Agricultural Chemical FDRL/Wistar Rats: Protocol No. 76081. (Unpublished study received Jun 4, 1976 under 3F1416; submitted by Pennwalt Corp., Tacoma, WA; CDL:095419 - A) 04 -Jun 1976 114537 Pennwalt Corp. (1973) Analyses for R esidues of Endothall in Various Crops. (Compilation; unpublished study received Jun 27, 1973 under 3F1416; CDL:095419 - D) 27 -Jun 1973 114538 Pennwalt Corp. (1969) Determination of Endothall Residues in Cottonseed and Cottonseed Products. (Compilation; unp ublished study received Apr 15, 1970 under 0F0972; CDL:095421 - A) 15 - Apr1970 114540 Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15, 1970 under 0F0972; submitted by Pennwalt Corp., Tacoma, WA; CDL:095421 - F) 15 - Apr1970 15 - Nov 114547 3M Co. (1965) Chemical and Physical Properties: System E. (Unpublished study received Dec 19, 1975 under 6H5112; CDL: 225291 - A) 1973 19 - Dec 1975 18 - Nov Kohn, F.; Kay, D. (1968) Report to Minnesota Mining and Manufacturing Co: Acute 1968 11 4548 Toxicity Studies on 3ME68H: Lifestream Laboratories Project Nos. 984 through 988. (Unpublished study received Dec 19, 1975 under 6H5112; prepared by Lifestream 15 - Nov 1973 Laboratorie s, Inc., submitted by 3M Co., St. Paul, MN; CDL:225291 - C) 19 - Dec 1975 114549 Economon, P. (1967) Letter sent to W. Paterson dated Nov 3, 1967 Results of bioassay on aquatic herbicide compounds. (Minnesota, Dept. of Conservation, D iv. of Game and Fish, Technical Services; unpublished study; CDL:225291 - D) 15 - Nov 1973 19 - Dec 1975 

### 91Whitley, J. (1968) Letter sent to W. Paterson dated Nov 18, 1968 Four - day fish toxicity 15 - Nov 114551 tests on bluegill sunfish, black bull - head and mosquitofish . (Missouri, Dept. of Conservation, Fisheries Research Laboratory, Water Quality Investigations; unpublished 1973 19 - Dec study; CDL:225291 - F) 1975 114552 Bionomics, Inc. (1971) The Acute Toxicity of System E (T - 350) to Bluegill ..., Rainbow Trout ..., and Largemouth Bass (Micropterus salmoides). (Unpublished study received Dec 19, 1975 under 6H5112; submitted by 3M Co., St. Paul, MN; CDL:225291 - G) 15 - Nov 1973 19 - Dec 1975 15 - Nov 114553 3M Co. (1971) Study IX: Field Trial Observations: System E. (Unpublis hed study received Dec 19, 1975 under 6H5112; CDL: 225291 - I) 1973 19 - Dec 1975 114554 3M Co. (1974) Residue Studies and Methods: System E. (Unpublished study received Dec 19, 1975 under 6H5112; CDL:225291 - J) 19 - Dec 1975 114555 Agchem (1977) Envir onmental Chemistry: Introduction: (Hydout). (Compilation; unpublished study received Oct 26, 1978 under 4581 - 282; CDL:235432 - A) 26 - Oct 1978 114556 Carlson, R.; Sandeno, J. (1970) Effect of Endothall on the Growth of Several Fungi. (Unpublished study rece ived Oct 26, 1978 under 4581 - 282; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:235432 - B) 26 - Oct 1978 114929 BASF Wyandotte Chemical Corp. (1973) Chemical Study: Pyramin - 283. (Compilation; unpublished study received Jan 30, 1973 under 7969 - 36; CDL:195084- A) 30 -Jan 1973 115377 Kratochvil, D. (1951) Determinations of the effect of several herbicides on soil microorganisms. Weeds 1:25 - 31. (Also In unpublished submission received Jun 14, 1971 under 748- 207; submitted by PPG Industries, Inc ., Barberton, OH; CDL:009051 - AF) 01 - May 1963 14 -Jun 1971 115982 Pennsalt Chemicals Corp. (1967) Full Reports of Investigations Made with Respect to the Safety of the Product: Des -I- Cate. (Unpublished study received Jun 16, 1967 under 7G0608; CDL: 090782- A) 16 -Jun 1967 Watson, J. (1972) Full Reports of Investigations Made with Respect to the Safety of the 116026 Pesticide Chemical: Endothall. Summary of studies 090872 - C through 090872- G. (Unpublished study received on unknown date under 1F1105; submittedby Pennwalt, Tacoma, WA; CDL:090872 - B) Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the 116029 Product: Endothall. (Unpublished study received on unknown date under 1F1105; submitted by Pennwalt, Takoma, WA; CDL: 090872 - H) Fink, R. (1975) Eight - day Dietary LC50 -- Bobwhite Quail: Technical Endothal: Project 116270 No. 110 - 105. Final report. (Unpublished study received Jul 9, 1975 under 1F1105; prepared by Truslow Farms, Inc., submitted by Pennwalt Corp., Tacoma, WA; 09 -Jul 1975 CDL:094702 - F) Fink, R. (1975) Eight - day Dietary LC50 -- Mallard Ducks: Technical Endothal: Project 116271 No. 110 - 106. Final report. (Unpublished study received Jul 9, 1975 under 1F1105; prepared by Truslow Farms, Inc., submitted by Pennwal t Corp., Tacoma, WA; 09 -Jul 1975 CDL:094702 - G) Mastri, C. (1971) Report to 3M Company: Acute Dermal Irritation/ Sensitization 15 - Nov 116272 Immersion Study with Two Concentrations of T - 370 in Albino Guinea Pigs: IBT No. A715. (Unpublished study received Dec 19, 1975 under 6H5112; prepared by Industrial 1973 19 - Dec Bio -Test Laboratories, Inc., submitted by 3M Co., St. Paul, MN; CDL:225291 - H) 1975 

### 92116465 Paterson, W. (1969) Aquatic Herbicide System S. (Unpublished study received Mar 6, 1969 under 7182 - EX - 6; submitted by Medical Products Div., 3M Co., St. Paul, MN; CDL:127050 - A) 06 - Mar1969 116739 Chevron Chemical Co. (1977) Residue Chemistry Data and Data Reference List To Support Label Amendment for Diquat Water Weed Killer. (Compilation; unpublished s tudy received Aug 22, 1977 under 239- 1663; CDL:231427 - A) 22 - Aug 1977 Scott, R.; Gangstad, E. (1971) Technical Report of Monitoring Guidelines for Use: 116862 Registration of Herbicides in Quiescent Aquatic Sites: AD882977. (U.S. Dept. of the Army, Officeof the Chief of Engineers, Interagency Technical Research Advisory 12 -Jul 1971 Committee, Aquatic Plant Control Program; unpublished study; CDL:091864 - C) Hughes, J.; Davis, J. (1963) Comparative Toxicity to Bluegill Sunfish of Granular and 117183 Liquid Herbicides. (Unpublished study received Nov 26, 1963 under unknown admin. no.; prepared by Louisiana, Wildlife & Fisheries Commission, submitted by Union 26 - Nov 1963 Carbide Agricultural Products Co., Inc., Research Triangle Park, NC; CDL:129700 - A) Hughes, J.; Davis, J. (1963) Comparative Toxicity to Bluegill Sun -fish of Granular and 1185 36 Liquid Herbicides. (Unpublished study received July 7, 1972 under 2F1213; prepared by Louisiana, Wild Life and Fisheries Commission, submitted by Amchem Products, In c., 07 -Jul 1972 Ambler, PA; CDL:091039- E) 118549 Amchem Products, Inc. (1971) Fenac Residue Data -- Total Water Treatment. (Compilation; unpublished study received Jul 7, 1972 under 2F1213; CDL:091039- T) 07 -Jul 1972 118951 Pennwalt Corp. (1982) Human Saf ety: Summary of Endothall Toxicity Data. (Unpublished study received Nov 23, 1982 under 1F1105; CDL:071249- A) 23 - Nov 1982 Harris, S.; Holson, J.; Barnett, W.; et al. (1982) A Teratology and Postnatal Behavioral 118952 Study of Endothall Technical in Albi no Rats: PNW/SAI 1182006. (Unpublished study received Nov 23, 1982 under 1F1105; prepared by Science Applications, Inc., submitted 23 - Nov 1982 by Pennwalt Corp., Tacoma, WA; CDL:071249- C) Harris, S.; Holson, J.; Barnett, W.; et al. (1982) A Dose R ange -finding Teratology Study 119989 of Endothall Technical and Disodium Endothal in Albino Rats: PNW/SAI 1182005. (Unpublished study received Nov 23, 1982 under 1F1105; prepared by Science 23 - Nov 1982 Applications, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL: 071249- B) Simsiman, G.; Daniel, T.; Chesters, G. (1976) Diquat and endothall: Their fates in the 121307 environment. Residue Reviews 62:131 - 174. (Also in unpublished submission received Dec 21, 1982 under 239-2247; submitted by Chevron Chemical Co ., Richmond, CA; 21 - Dec 1982 CDL: 249102- E) 124003 Pennwalt Corp. (1975) Phytotoxicity to Irrigated Crops: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094705 - A) 09 -Jul 1975 124005 Agchem (1975) Full Reports and Dat a of Investigation Made on the Effectiveness of the Product: Endothall. (Compilation; unpublished study received Feb 1, 1975 under 4581 - EX - 21; CDL: 094728 - A) 01 - Feb 1975 124622 Agchem (1970) Some Additional Information Pertaining to Fate of Endothall in the Environment: Summary. (Unpublished study received Dec 1, 1970 under 1F1105; CDL:094511 - A) 01 - Dec 1970 124624 Oregon State Univ. (1963) Progress Report on the Soil Behavior of Endothal. (Unpublished study received Dec 1, 1970 under 1F1105; submitted b y Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:094511 - D) 01 - Dec 1970 14 - Nov 1984 

### 93Freed, V. (1963) Progress Report on the Study of the Degradation Products of Endothal 01 - Dec 124625 in Soil. (Unpublished study received Dec 1, 1970 under 1F1105; prepared by Oregon State Univ., submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL: 1970 14 - Nov 094511 - F) 1984 124626 Oregon State Univ. Preliminary Investigations of the Behavior of Endothal in Water. (Unpublished study received Dec 1, 1970 un der 1F1105; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:094511 - G) 01 - Dec 1970 124627 Horowitz, M. (1966) Breakdown of Endothal in soil. Weed Research 6(2):168- 171. (Also In unpublished submission received Dec 1, 1970 under 1F1105; sub mitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:094511 - H) 01 - Dec 1970 124628 Oregon State Univ. Preliminary Study on Microbial Effect on Endothal. (Unpublished study received Dec 1, 1970 under 1F1105; submitted by Agchem Div., Pennwalt Corp. , Philadelphia, PA; CDL:094511 - I) 15 - Feb 1967 01 - Dec 1970 Jensen, H. (1964) Studies on soil bacteria (Arthrobacter globi - formis) capable of 124629 decomposing the herbicide Endothal. Acta Agr. Scand. 14:193 - 207. (Also In unpublished submission received D ec 1, 1970 under 1F1105; submitted by Agchem Div., Pennwalt 01 - Dec 1970 Corp., Philadelphia, PA; CDL:094511 - J) 124630 Debona, A.; Audus, L. (1970) Studies on the effects of herbicides on soil nitrification. Weed Res. 10:250 - 263. (Also In unpublished subm ission received Dec 1, 1970 under 1F1105; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:094511 - K) 01 - Dec 1970 124659 Brieger, H.; Stasney, J. Endothal: Short - term Oral Toxicity Test. (Unpublished study received Dec 15, 1964 under 7F057 0; prepared by Jefferson Medical College, submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:094580 - A) 15 - Dec 1964 124660 Brieger, H.; Stasney, J. (1952) Endothal: Long - term Oral Toxicity Test. (Unpublished study received Dec 15, 1964 under 7F0570; prepared by Jefferson Medical College, submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:094580 - B) 15 - Dec 1964 Brieger, H.; Stasney, J. (1951) Exposure of Rats to a Fine Mist Containing Disodium 3,6- 124662 Endoxohexahydrophthalate ( Endothal) and Formulated Endothal. (Unpublished study received Dec 15, 1964 under 7F0570; prepared by Jefferson Medical College, submitted 15 - Dec 1964 by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:094580 - D) 133190 Pennwalt Corp. (1970) Fate of En dothall in Crops and Animals. Unpublished compilation. 305 p. 27 - Apr1970 House, W.; Goodson, L.; Gadberry, H.; et al. (1967) Assessment of Ecological Effects of 136298 Extensive or Repeated Use of Herbicides: MRI Project No. 3103 - B; Contract No. DAHC15 - 68 - C - 0119. Final report. (Unpublished study received Aug 12, 1970 under 12 - Aug 1970 1E1046; submitted by Department of the Army, N. Fort Mead, MD; CDL: 093358- C) 138447 Agchem (1965) Study: Efficacy of Specified Aquatic Pesticides. (Compilation; unpublis hed study received Mar 15, 1966 under 4581 - 139; CDL:007441 - R) 15 - Mar1966 138449 Sikka, H.; Saxena, J. Metabolism of endothall by aquatic microorganisms. J. Agr. Food Chem. 21(3). (Also In unpublished submission received Feb 1, 1975 under 4581 - EX - 21; su bmitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:094726- B) 01 - Feb 1975 Turgeon, A. (1971) The Role of ... (Endothall) in Annual Bluegrass ... Control in Turf. 138450 Doctor's thesis, Michigan State Univ., Dept. of Crop and Soil Sciences. (Un published study received May 4, 1972 under 4581 - 284; submitted by Agchem Div., Pennwalt 04 - May 1972 Corp., Philadelphia, PA; CDL:095336- A) 

### 94139687 Munter, P. (1960) Letter sent to I. Gauditz dated May 26, 1960: Endothal analysis. (Unpublished study receiv ed Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, TX; CDL:090587- N) 10 - Apr1966 07 -Jun 147122 Carlson, R. (1985) The Hydrolysis of Endothall in Water: Project No. WT - 3 - 85. Unpublished study prepared by Pennwalt Corp. 18 p. 1985 05 - Aug 1985 147123 Pennwalt Corp. (1985) Photodegradation of Endothall in Water. Unpublished study. 9 p. 05 - Aug 1985 07 -Jun 147124 Pennwalt Corp. (1985) Photodegradation of Endothall on Soil. Un -published study. 10 p. 1985 05 - Aug 1985 149675 Pennwalt Corp. (1985) Photodegradation of Endothall in Water: [Opinion -- That Photolysis of Endothall is Not a Relevant Factor in Determining Its Environmental Fate]. Unpublished study. 10 p. 07 -Jun 1985 151771 Pennwalt Corp. (1984) EPA Ground Water Data Call - in for Endothall of July 27, 1984: Product Chemistry. Unpublished study. 1 p. 14 - Nov 1984 156635 Dykeman, R. (1985) Adsorption/Desorption of Endothall on Soils by Batch Equilibrium Method: Final Report: Project No. WT - 7 - 85. Unpublished study prepared by Pen nwalt Corporation, Agchem Division. 71 p. 10 - Feb 1986 162920 Dykeman, R. (1986) Aerobic/Anaerobic Soil Metabolism of Endothall: Final Report: Project No. WT - 86- C- 1. Unpublished study prepared by Agchem Div., Pennwalt Corp. 185 p. 15 - Aug 1986 162921 Jac obson, S. (1986) Terrestrial Field Dissipation Studies for Endothall (Herbicide 273 and Des -I- Cate Harvest Aid Formulations): Final Report: Project WT - 1 - 85 and WT- 2- 85. Unpublished study prepared by Agchem Div., Pennwalt Corp. 125 p. 15 - Aug 1986 165311 P arisot, T. (1968) Letter sent to W. Paterson dated Oct 2, 1968: [Toxicity test conducted for some 3M experimental herbicides]. Prepared by US Dept., of Interior, Fish and Wildlife Services. 1 p. 15 - Nov 1973 165312 Supervisor Product Toxicology - 3M Co. ( 1973) Residue Studies and Methods: [Endothall]. Unpublished study. 45 p. 15 - Nov 1973 Nebeker, A.V.; Gaufin, A.R. (1964) Bioassays to determine pesticide toxicity to the 5001624 amphipod crustacean, Gammarus lacustris. Pages 64 - 67, in Utah Academy of Scie nces Proceedings. Vol. 41, Part I. Salt Lake City, Utah: Utah Academy of Sciences, Arts and Letters. 40109200 Pennwalt Corp. (1987) Submission of Product Chemistry and Toxicity Studies in Support of Application for Registration of Endothall 30P. Transm ittal of 4 studies. 06 - Mar1987 40109201 Harvey, J. (1986) Endothal 30P -- Product Chemistry. Unpublished compilation prepared by Pennwalt Corp. 10 p. 06 - Mar1987 40109202 Smith, S. (1986) Acute Oral LD50 Study in Rats with Pelletted Endothall: Project I D: 480 - 2553. Unpublished study prepared by American Biogenics Corp. 32 p. 06 - Mar1987 40109203 Smith, S. (1986) Acute Dermal LD50 Study in Rabbits with Pelletted Endothall: Project ID: 480 - 2578. Unpublished study prepared by American Biogenics Corp. 29 p . 06 - Mar1987 40109204 Smith, S. (1986) Primary Dermal Irritation Study in Rabbits with Pelletted Endothall: 06 - Mar

### 95Project ID: 480 - 2538. Unpublished study prepared by American Biogenics Corp. 16 p. 1987 41040300 Pennwalt Corp. (1989) Submission of Dat a To Support Registration of Endothall: Toxicology Data. Transmittal of 1 study. 23 - Mar1989 41040301 MacKenzie, K. (1989) Combined Chronic Toxicity and Carcinogenicity Study in Rats: Project ID: HLA 6120 - 110. Unpublished study pre -pared by Hazleton Lab oratories America, Inc. 385 p. 23 - Mar1989 41616400 Atochem North America (1990) Submission of Product Chemistry Data and Environmental Fate Data to Support the List B Phase 2/3 Response of Endothal. Transmittal of 4 Studies. 31 - Aug 1990 41616404 Vigon , B. (1989) Adsorption/Desorption of Carbon 14 ring (2,3) Endothall on Soils by the Batch Equilibrium Method: Lab Project Number: NO962/6200. Unpublished study prepared by Battelle. 68 p. 31 - Aug 1990 41622800 Atochem North America (1990) Submission of Pr oduct Chemistry Data to Support Phase 2/3 Response for Endothall and Salts. Transmittal of 2 studies. 07 - Sep 1990 41622801 Hoffman, M. (1988) Water Solubility Determination of Endothall: Lab Project Number: HLA/6001/183. Unpublished study prepared by Haz leton Laboratories America, Inc. 92 07 - Sep 1990 p. 41622802 Hoffman, M. (1988) Determination of Vapor Pressure: Lab Project Number: HLA/6001/184. Unpublished study prepared by Hazleton Laboratories America, Inc. 120 07 - Sep 1990 p. 41700300 Atochem Nort h America (1990) Submission of Toxicology Data To Support List B ­ Phase 2/3 Response for Endothall Technical. Transmittal of 3 studies. 27 - Nov 1990 41700301 Mackay, J. (1989) Endothall Technical: Assessment of Clastogenic Action on Bone Marrow Erythrocy tes in the Micronucleus Test: Lab Project Number: PSV/034: 89/PSV034/0044. Unpublished study pre -pared by Life Science Research. 34 p. 27 - Nov 1990 Bootman, J.; Hodson -Walker; G.; Dance, C. (1989) In vitro Assessment of the 41700302 Clastogenic Activity of Endothall Technical in Cultured Human Lymphocytes: Lab Project Number: PSV/027. Un - published study prepared by Life Science Research Ltd. 27 - Nov 1990 31 p. 41700303 Bootman, J.; May, K. (1988) Endothall Technical: Assessment of its Ability to Cause L

ethal DNA Damage in Strains of Escherichia coli: Lab Project Number: PSV/028. Unpublished study prepared Life Science Research Ltd. 26 p. 27 - Nov 1990 42221500 Atochem North America (1992) Submission of Data in Response to Data Call - in for Endothall: Toxi cology Study. Transmittal of 1 study. 28 - Feb 1992 42221501 Cracknell, S. (1988) Endothall Technical: Acute Inhalation Toxicity Study in the Rat: Lab Project Number: 90/PSV024/0970: 88/0598. Unpublished study prepared by Life Science Research Ltd. 5 p. 28 - Feb 1992 42289200 Atochem North America (1992) Submission of Data in Support of Endothall Acid (Technical) as Required in the List B Reregistration DCI: Toxicology and Environmental Fate Studies. Transmittal of 7 studies. 20 - Apr1992 42289201 Mallory, V. (1991) Acute Exposure Oral Toxicity in Rats with Endothall Technical: Lab Project Number: PH 402 - ANA - 002 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 53 p. 20 - Apr1992 42289202 Mallory, V. (1991) Acute Exposure Dermal Toxi city with Endothall Technical: Rabbit: Lab Project Number: PH 422 - ANA - 002 - 91. Unpublished study prepared by Pharmakon 20 - Apr1992 

### 96Research International, Inc. 31 p. 42289203 Mallory, V. (1991) Primary Eye Irritation with Endothall Technical: Rabbit: Lab Project Number: PH 421 - ANA - 002 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 35 p. 20 - Apr1992 42289204 Mallory, V. (1992) Primary Dermal Irritation Study with Endothall Technical: Rabbit: Lab Project Number: PH 420 - ANA - 002 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 27 p. 20 - Apr1992 42289205 Saxena, A.; Marsh, S. ; Koebel, D. (1991) Photodegradation of carbon 14 - Endothall in a Buffered Aqueous Solution Under Artificial Sunlight: Final Report: Lab Project Number: SC910024: BR - 91 - 25. Unpublished study prepared by Battelle. 55 p. 20 - Apr1992 42289206 Zwick, T.; Kazee, B.; Marsh, S. (1990) Photodegradation of carbon 14 Endothall in Water Under Artificial Light: Final Report: Lab Project Number: SC89 0059. Unpublished study prepared by Battelle. 92 p. 20 - Apr1992 42289207 Saxena, A.; Zwick, T.; Marsh, S.; et al. (1991) Photodegradation of carbon 14 - Endothall on Sandy Loam Soil Under Artificial Light: Final Report: Lab Project Number: SC890060: BR - 90- 02. Unpublished study prepared by Battelle. 67 p. 20 - Apr1992 42327700 Atochem North America, Inc. (1992) Submission of Toxicity data in support of Reregistration for Endothall. Transmittal of 2 studies. 26 - May 1992 Bettencourt, M. (1992) Endo thall Technical - Acute Toxicity to Bluegill Sunfish (Lepomis 42327701 macrochirus) under Flow- through Conditions: Lab Project Number: 91 - 9 - 3917: 12442.0591.6121.105. Unpublished study prepared by Springborn Laboratories, Inc. 62 26 - May 1992 p. Bettencourt , M. (1992) Endothall Technical - Acute Toxicity to Rainbow Trout 42327702 (Oncorhynchus mykiss) Under Flow - through Conditions: Lab Project Number: 91 - 9 - 3918: 12442.0591.6120.108. Unpublished study prepared by Springborn Laboratories, 26 - May 1992 Inc. 63 p. 4235970 0 Atochem North America (1992) Submission of Data in Support of Endothall Acid (Technical) as Required in the Reregistration DCI: Toxicology Studies. Transmittal of 2 studies. 17 -Jun 1992 42359702 McNamara, P. (1992) Endothall Technical -- Acute Toxicity t o Daphnids (Daphnids magna) Under Flow - through Conditions: Final Report: Lab Project Number: 91 - 10 - 3946: 12442.0591.6122.115. Unpublished study prepared by Springborn Labs., Inc. 64 p. 17 -Jun 1992 42408700 Atochem North America, Inc. (1992) Submission of toxicity data in support of the data call - in for Endothall. Transmittal of 1 study. 21 -Jul 1992 42408701 Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Endothall Technical in the Rat: Lab Project Number: 91 - 8355. Unpublished study prepared by Bio/dynamics, Inc. 132 p. 21 -Jul 1992 42427900 Atochem North America, Inc. (1992) Submission of product chemistry data in support of the reregistration of endothall. Transmittal of 1 study. 05 - Aug 1992 42427901 Douglass, M. (1992) Endothall -- Analysis o f Product Samples: Lab Project Number: 4200- 91 - 0279- AS: 4200- 91 - 0279- AS - 001. Unpublished study prepared by Ricerca, Inc. 71 p. 05 - Aug 1992 42507300 ELF Atochem (1992) Submission of toxicity data to support endothall reregistration. Transmittal of 2 studi es. 10 - Oct 1992 42507301 Pedersen, C.; Fletcher, D. (1992) Endothall Technical: Toxicity and Reproduction Study 10 - Oct 

### 97in Mallard Ducks: Lab Project Number: 89 DR 37. Unpublished study prepared by Bio ­ 1992 Life Associates, Ltd. 300 p. 42507302 Pedersen , C.; Fletcher, D.; Lesar, C. (1992) Endothall Technical: Toxicity and Reproduction Study in Bobwhite Quail: Lab Project Number: 89 QR 41. Unpublished study prepared by Bio - Life Associates, Ltd. 301 p. 10 - Oct 1992 42619200 Atochem North America, Inc. (1992) Submission of residue data in support of the data call - in for Endothall Acid (technical). Transmittal of 3 studies. 08 -Jan 1993 42619201 Sanger, T. (1992) Nature of the Residue in Alfalfa: (carbon 14)- Endothall: Final Report: Lab Project Number: HWI 6120- 154: BR - 91 - 48. Unpublished study prepared by Hazleton Wisconsin, Inc. 108 p. 08 -Jan 1993 42619202 Sanger, T. (1992) Nature of the Residue in Cotton: (carbon 14) - Endothall: Final Report: Lab Project Number: HWI 6120 - 152: BR - 91 - 49. Unpublished study p repared by Hazleton Wisconsin, Inc. 138 p. 08 -Jan 1993 42619203 Sanger, T. (1992) Nature of the Residue in Sugar Beets: (carbon 14) - Endothall: Final Report: Lab Project Number: HWI 6120 - 150: BR - 91 - 50. Unpublished study prepared by Hazleton Wisconsin, Inc . 114 p. 08 -Jan 1993 42629700 Elf Atochem N.A., Inc. (1993) Submission of product chemistry data in support of the data call - in for Endothall Acid (technical). Transmittal of 1 study. 21 -Jan 1993 42629701 Sweetapple, G. (1992) Endothall Acid Monohydrat e, TG -- Color, Physical State, Odor, Melting Point, Bulk Density, pH: Lab Project Number: 4200 - 92- 0172- AS: 4200- 92- 0172- AS - 001. Unpublished study prepared by Ricerca, Inc. 36 p. 21 -Jan 1993 42641200 Atochem N.A., Inc. (1992) Supplemental Submission of env ironmental fate data to support the Endothall reregistration. Transmittal of 2 studies. 27 -Jan 1993 42641201 Zwick, T.; Kazee, B.; Marsh, S. (1992) Photodegradation of (carbon 14) - Endothall in Water under Artificial Light: Amended Final Report: Lab Proje ct Number: SC890059: N0758 - 4400. Unpublished study prepared by Battelle. 92 p. 27 -Jan 1993 42641202 Saxena, A.; Zwick, T.; Marsh, S.; et al. (1992) Photodegradation of (carbon 14)- Endothall on Sandy Loam under Artificial Light: Amended Final Report: Lab Project Number: SC890060: BR - 90- 02. Unpublished study prepared by Battelle. 67 p. 27 -Jan 1993 42668000 Atochem North America (1993) Submission of product chemistry data in support of the data call - in for Endothall Acid (Technical). Transmittal of 1 study . 17 - Feb 1993 42668001 Gallacher, A. (1993) Endothall Acid Monohydrate -- Dissociation Constant: Lab Project Number: 4200 - 92 - 0133 - AS: 4200- 92 - 0133 - AS - 001. Unpublished study prepared by Ricerca, Inc. 54 p. 17 - Feb 1993 42776300 Elf Atochem North America, I nc. (1993) Submission of toxicity data in support of the reregistration DCI for Endothall Acid. Transmittal of 1 study. 18 - May 1993 42776301 Trutter, J. (1993) Rat Developmental Toxicity Study with Disodium Salt of Endothall: Final Report: Lab Project Nu mber: 153 - 146. Unpublished study prepared by Hazleton Washington, Inc. 289 p. 18 - May 1993 42792700 Elf Atochem North America, Inc. (1993) Submission of metabolism data in response to DCI for Endothall Acid (Technical). Transmittal of 2 studies 01 -Jun 19 93 42792701 Sanger, T. (1993) Metabolism of (carbon 14)- Endothall in Lactating Goats: Final Report: Lab Project Number: HWI 6120 - 158: BR - 91 - 52. Unpublished study prepared by Hazleton Wisconsin, Inc. 103 p. 01 -Jun 1993 

### 9842816600 Elf Atochem North America, Inc. (1993) Submission of residue data in response to DCI for reregistration of Endothall Acid (Technical). Transmittal of 1 study. 01 -Jun 1993 42816601 Sanger, T. (1993) Metabolism of (carbon 14)- Endothall in Laying Hens: Final Report: Lab Project Numb er: HWI 6120 - 160: BR - 91 - 51. Unpublished study prepared by Hazleton Wisconsin, Inc. 118 p. 01 -Jun 1993 42895200 Elf Atochem North America, Inc. (1993) Submission of Toxicology Data in Support of Endothall Acid as Required for Reregistration. Transmittal o f 1 study. 24 - Aug 1993 Dionne, E. (1993) Endothall Technical -- Acute Toxicity to Eastern Oyster (Crassostrea 42895201 virginica) Under Flow - through Conditions: Final Report: Lab Project Number: 93 - 4- 4715: 12442.0591.6125.504. Unpublished study prepared by Springborn Laboratories, 24 - Aug 1993 Inc. 68 p. 42914100 Elf Atochem North America, Inc. (1993) Submission of Acute Toxicology Data for Endothall Acid (Technical) in Support of Reregistration. Transmittal of 2 Studies. 08 - Sep 1993 Bettencourt , M. (1993) Endothall Technical - Acute Toxicity to Mysid Shrimp 42914101 (Mysidopsis bahia) Under Flow - Through Conditions: Final Report: Lab Project Number: 12442.0591.6124.515: 93 - 3 - 4711. Unpublished study prepared by Springborn Labs, Inc. 08 - Sep 1993 67 p. Bettencourt, M. (1993) Endothall Technical - Acute Toxicity to Sheepshead Minnow 42914 102 (Cyprinodon variegatus) Under Flow - Through Conditions: Final Report: Lab Project Number: 92 - 1 - 4901: 12442.0591.6123.505. Unpublished study prepared by Springborn 08 - Sep 1993 Labs, Inc. 65 p. 43007800 Elf Atochem North America, Inc. (1993) Submission of Toxicology Data in Support of Endothall Data Call - in. Transmittal of 1 Study. 15 - Nov 1993 43007801 Putt, A. (1993) Endothall Technical (Acid) -- The Chronic Toxicity to Daphn ia magna Under Flow - Through Conditions: Final Report: Lab Project Number: 92 - 11 - 4525: 12442.0692.6148.130. Unpublished study prepared by Springborn Labs, Inc. 99 p. 15 - Nov 1993 43081900 Elf Atochem North America, Inc. (1993) Submittal of Corrosion Charac teristics Data in Support of Reregistration of Endothall Acid Monohydrate. Transmittal of 1 study. 11 -Jan 1994 43081901 Sweetapple, G. (1993) Endothall Acid Monohydrate, TG -- Corrosion Characteristics: Lab Project Number: 4200 - 92 - 0173 - AS. Unpublished stud y prepared by Ricerca, Inc. 36 p. 11 -Jan 1994 43152100 Elf Atochem North America, Inc. (1994) Submission of toxicity data in support of reregistration for Endothall Acid Technical. Transmittal of 1 study. 09 - Mar1994 43152101 Trutter, J. (1993) Two - Gen eration Reproduction Study in Rats with Disodium Salt of Endothall: Final Report: Lab Project Number: 153/142. Unpublished study prepared by Hazleton Washington, Inc. 1479 p. 09 - Mar1994 43167700 Elf Atochem North America, Inc. (1994) Submittal of Dietar y Toxicity Data in Support of Reregistration of Endothall Acid. Transmittal of 2 studies. 22 - Mar1994 43167701 Pedersen, C.; Solatycki, A. (1994) Endothall Technical: 8- Day Acute Dietary LC 50 Study in Bobwhite Quail: Lab Project Number: 106 - 011 - 01. Unpu blished study prepared by Bio - Life Associates, Ltd. 96 p. 22 - Mar1994 43167702 Pedersen, C.; Solatycki, A. (1994) Endothall Technical: 8- Day Acute Dietary LC 50 Study in Mallard Ducklings: Lab Project Number: 106- 015 - 02. Unpublished study prepared by Bio - Life Associates, Ltd. 94 p. 22 - Mar1994 43265000 Elf Atochem North America, Inc. (1994) Submission of product chemistry (stability) data in support of reregistration of Endothall Acid Monohydrate. Transmittal of 1 study. 10 -Jun 1994 

### 9943265001 Malone, S . (1994) Endothall Acid Monohydrate TG (B44- 26- 3): Stability: Lab Project Number: 4200/92/0184/AS. Unpublished study prepared by Ricerca, Inc. 56 p. 10 -Jun 1994 43295400 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data in Support of End othall Reregistration. Transmittal of 1 Study. 07 -Jul 1994 Bettencourt, M. (1994) Endothall Technical (Acid) -- The Toxicity to Fathead Minnow 43295401 (Pimephales promelas) During an Early Life - stage Exposure: Final Report: Lab Project Number: 93 - 1 - 4567: 12442.0692.6149.120. Unpublished study prepared by Springborn 07 -Jul 1994 Labs, Inc. 84 p. 43300700 Elf Atochem North America, Inc. (1994) Submission of Environmental Fate Data in Support of Endothall Reregistration. Transmittal of 1 Study. 18 - May 1994 43300701 Sanger, T. (1994) (Carbon 14) - Endothall: Accumulation in Confined Rotational Crops (Greenhouse Study): Final Report: Lab Project Number: HWI 6120 - 148: BR - 91 - 47: R149104. Unpublished study prepared by Hazleton Wisconsin, Inc. 240 p. 18 - May 1994 43327700 Elf Atochem North America, Inc. (1994) Submittal of Toxicity Data in Support of Reregistration for Endothall. Transmittal of 1 study. 04 - Aug 1994 43327701 Armondi, S. (1994) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with Accelera te: Lab Project Number: PH - 424- ANA - 003 - 93. Unpublished study prepared by Pharmakon Research International, Inc. 107 p. 04 - Aug 1994 43339300 Elf Atochem North America, Inc. (1994) Submission of Product Chemistry Data in Support of Endothall Reregistration . Transmittal of 1 Study. 16 - Aug 1994 43339301 Lorence, P. (1994) Endothall Acid Monohydrate, PAI - Solubility: Lab Project Number: 4200- 92 - 0135 - AS: 4200- 92- 0135 - AS - 001. Unpublished study prepared by Ricerca, Inc. 84 p. 16 - Aug 1994 43558200 Elf Atochem N orth America, Inc. (1995) Submission of Hazard to Non -target Organisms Data in Support of Endothall Reregistration. Transmittal of 2 Studies. 24 - Feb 1995 Rose, S.; Goin, L. (1994) Endothall Technical: 28 - Day Dietary Toxicity and 43558201 Reproduction Pi lot Study in Mallard Ducks: Addendum: Diet Analyses: Final Report: Lab Project Number: 89 DRP 37: 33400. Unpublished study prepared by NPC, Inc.; 24 - Feb 1995 Columbia Labs, Inc.; and Bio - Life Associates, Ltd. 49 p. Rose, S.; Goin, L. (1994) Endo thall Technical: Toxicity and Reproduction Study in 43558202 Mallard Ducks: Addendum: Diet Analyses: Final Report: Lab Project Number: 89 DR 37: 0660: 09356. Unpublished study prepared by NPC, Inc.; Columbia Labs, Inc.; and Bio 24 - Feb 1995 Life Associates, Ltd. 47 p. 43558300 Elf Atochem North America, Inc. (1995) Submission of Toxicity Data in Support of the Endothall Registration Standard. Transmittal of 2 Studies. 24 - Feb 1995 Rose, S.; Goin, L. (1994) Endothall Technical: 28 - Day Dietary Toxicity and 43558301 Reproduction Pilot Study in Bobwhite Quail: Addendum: Diet Analyses: Final Report: Lab Project Numbers: BLAL 89 QRP 41: 33400: 153 - 144. Unpublished study prepared 24 - Feb 1995 by Columbia Labs, Inc.; NPC, Inc.; Bio - Life Associates, Ltd. 49 p. Ros e, S.; Goin, L. (1994) Endothall Technical: Toxicity and Reproduction Study in 43558302 Bobwhite Quail: Addendum: Diet Analyses: Final Report: Lab Project Numbers: BLAL 89 QR 41: 0660: 09356. Unpublished study prepared by Columbia Lab, Inc.; NPC, Inc.; 24 - Feb 1995 Bio - Life Ass ociates, Ltd. 47 p. 43953100 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the Reregistration of Endothall and Salts. Transmittal of 1 Study. 15 - Mar1996 

### 10043953101 Guyton, B. (1996) Endothall: Magnitude of t he Residue in Potato: Lab Project Number: BR - 93 - 01: U:\ ATOCHEM \ BR9301FR.DOC. Unpublished study prepared by McKenzie Laboratories, Inc. 315 p. 15 - Mar1996 43975900 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the Reregis tration of Endothall, K - Salt. Transmittal of 1 Study. 25 - Mar1996 43975901 Guyton, B. (1996) Endothall: Magnitude of the Residue in Sugar Beets: Final Report: Lab Project Number: BR - 93 - 02. Unpublished study prepared by Elf Atochem North America and Mcken zie Labs, Inc. 347 p. 25 - Mar1996 44077800 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of Endothall and Salts Reregistration. Transmittal of 1 Study. 07 - Aug 1996 Sanger, T. (1996) Storage Stability Data for (carbon 14) Endothall Plant Metabolism 44077801 Studies (Addenda to MRID #'s 42619201, 42619202, 42619203): Lab Project Number: HWI 6120 - 150: HWI 6120 - 152: HWI 6120 - 154. Unpublished study prepared by 07 - Aug 1996 Hazleton Wisconsin, Inc. 8 p. 44106300 Elf Atochem Nor th America, Inc. (1996) Submission of Residue Data in Support of the Reregistration for Endothall and Salts. Transmittal of 1 Study. 10 - Sep 1996 44106301 Sharp, J. (1996) Endothall: Storage Stability of Residues in Cottonseed: Lab Project Number: BR - 93 - 3 0: 30 - 93: PRM - 047. Unpublished study prepared by Elf Atochem North America, Inc. and McKenzie Laboratories, Inc. 170 p. 10 - Sep 1996 44263500 Elf Atochem North America, Inc. (1997) Submission of Metabolism and Residue Data in Support of the Reregistrationof Endothall and Salts. Transmittal of 8 Studies. 29 - Apr1997 44263501 Bounds, S. (1997) Endothall: Metabolism and Excretion Study in the Rat: Final Report: Lab Project Number: KP - 96- 02: 96/1290: 96/EFM001/1290. Unpublished study prepared by Huntingdon Life Sciences Ltd. 182 p. 29 - Apr1997 44320400 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of Petition for Tolerance for Endothall on Apples. Transmittal of 3 Studies. 03 -Jul 1997 44320403 Piccirillo, V. (1997) FQPA Sup plemental Information on Endothall: Lab Project Number: FQPA 697E. Unpublished study prepared by Elf Atochem N.A., Inc. 42 p. 03 -Jul 1997 44578400 Elf Atochem North America, Inc. (1998) Submission of Environmental Fate Data in Support of the Reregistrati on of Endothall Acid and Salts. Transmittal of 1 Study. 11 -Jun 1998 44578401 Mao, J. (1997) Endothall Amine Salt -- Determination of pH Dependent Hydrolysis: Lab Project Number: 12442.0396.6209.715: KP - 96 - 01: 96 - 6- 6537. Unpublished study prepared by Spring born laboratories, Inc. 79 p. 11 -Jun 1998 44608600 Elf Atochem North America, Inc. (1998) Submission of Residue Chemistry Data in Support of the Reregistration of Endothall Acids and Salts. Transmittal of 1 Study. 16 -Jul 1998 44608601 Fomenko, J. (1998) Evaluation of Endothall Through the FDA Multiresidue Methods: Lab Project Number: A036.50: KP - 97 - 18. Unpublished study prepared by Maxim Technologies, Inc. 63 p. {OPPTS 860.1360} 16 -Jul 1998 44820100 Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, Risk Assessment and Exposure Data in Support of the Reregistration of Endothall Acid and Salts. Transmittal of 4 Studies. 05 - May 1999 Keckemet, O.; Sharp, J. (1999) Historical Aquatic Residue and Dissipation Data for 44820101 Endotha ll Aquatic Products Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: Lab Project Number: KP - 99 - 02: WT- 86- C- 11. Unpublished 05 - May 1999 study prepared by Elf Atochem. 316 p. {OPPTS 860.1400} 

### 101Dionne, E.; Sharp, J.; Fo rmella, T. (1999) Dipotassium Salt of Endothall: A Freshwater 44820102 Fish and Shellfish Magnitude of Residues Study in a Static Aquatic System: Lab Project Number: KP - 97 - 14: 52897/171.4/FIFRA: EN1115.95. Unpublished study prepared by Elf 05 - May 1999 Atochem and ABC Laborator ies, Inc. 213 p. {OPPTS 860.1400} 44820103 Biever, R. (1998) Hydrothol 191: An Aquatic Dissipation Study for Aquatic Non - Crop Uses: Final Report: Lab Project Number: KP - 96- 14: 98- 1 - 7215: 12442- 0896- 6214- 330. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 164 p. 05 - May 1999 44820104 Giddings, J. (1999) Ecological Risk Assessment of Aquatic Herbicides Containing Endothall: Final Report: Lab Project Number: KP - 98 - 31: 98- 11 - 7564: 12442 - 0898 - 6271 - 251. Unpublished stud y prepared by Elf Atochem and Springborn Laboratories, Inc. 64 p. 05 - May 1999 44828800 Elf Atochem North America (1999) Submission of Environmental Fate Data in Support of the Reregistration of Endothall Acid and Salts Containing Products Aquathol K and Hydrothal 191. Transmittal of 2 Studies. 05 - May 1999 Singh, P.; Ritter, A.; Sharp, J. et al. (1999) Aquatic Dissipation Modeling of Endothall 44828801 Acid: Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: Lab Project Number : ATO KP- 97 - 16: WEI 286.01. Unpublished study prepared by 05 - May 1999 Waterborne Environmental, Inc. 363 p. Williams, W.; Ritter, A.; Sharp, J. et al. (1999) An Evaluation of the Aquatic Dissipation 44828802 of Endothall Aquatic Product: Aquathol, K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: Lab Project Number: ATOKP - 98 - 32: WEI - 286.06. Unpublished 05 - May 1999 study prepared by Waterborne Environmental, Inc. 69 p. 44856300 Elf Atochem North America, Inc. (1999) Submission of Toxi city, Residue Chemistry, Risk Assessment and Exposure Data in Support of the Petition for Tolerance of Endothall in/on Edible Fish. Transmittal of 1 Study. 21 -Jun 1999 44856301 Piccirillo, V. (1999) FQPA Supplemental Information on Endothall: Lab ProjectNumber: FQPA 499E. Unpublished study prepared by Elf Atochem North America, Inc. 35 p. 21 -Jun 1999 44949200 Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the Reregistration of Endothall and its Salts. Transmittal of 2 Studies. 20 - Oct 1999 Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 96 - Hour 44949201 Toxicity Test with the Freshwater Diatom (Navicula pelliculosa): Final Report: Lab Project Number: 299A - 102. Unpublished study prepared by Wild life International Ltd. 38 20 - Oct 1999 p. {OPPTS 850.5400} Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 96 - Hour 44949202 Toxicity Test with the Freshwater Alga (Anabaena flos - aquae): Final Report: Lab Project Number: 299A - 101. Unpublished study prepared by Wildlife International Ltd. 36 p. 20 - Oct 1999 {OPPTS 850.5400} 44949400 Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, and Toxicity Data in Support of the Reregistration of Endothall Acid & Salts. Transmittal of 3 Studies. 20 - Oct 1999 44949401 Atkins, R.; Peel, D.; Marsh, D. (1999) Aerobic Soil Metabolism of (carbon - 14) Endothall: Lab Project Number: 1134: 2045: KP - 97 - 24. Unpublished study prepared by PTRL East, Inc. 167 p. 20 - Oct 1999 44949402 Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 7- Day Toxicity Test with Duckweed (Lemna gibba G3): Final Report: Lab Project Number: 299A - 105. Unpublished study prepared by Wildlife International Ltd. 34 p. {OPPTS 850.4400} 20 - Oc t 1999 44949403 Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 7- Day Toxicity 20 - Oct 

### 102Test with The Freshwater Alga (Selenastrum capricornutum): Final Report: Lab Project 1999 Number: 299A - 103. Unpublished study prepared by Wildlife Internati onal Ltd. 36 p. {OPPTS 850.5400} 44976700 Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the Reregistration of Endothall Acids and Salts Containing Product Hydrothol 191. Transmittal of 1 Study. 20 - Oct 1999 Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191: A 96 - Hour Toxicity Test with 44976701 the Marine Diatom (Skeletonema costatum): Final Report: Lab Project Number: 299A 104. Unpublished study prepared by Wildlife International , Ltd. 38 p. {OPPTS 20 - Oct 1999 850.5400} 45034700 IR - 4 Project (2000) Submission of Residue Chemistry Data in Support of the Petition for Tolerance of Endothall in/on Hops. Transmittal of 1 Study. 24 -Jan 2000 45034701 Arsenovic, M. (2000) Endothall: Magnitude of the Res idue on Hops: Lab Project Number: 06575: 06575.97 - CAR07: 06575. 97- ID22. Unpublished study prepared by IR - 4 Project. 125 p. {OPPTS 860.1500} 24 -Jan 2000 45039500 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in Support of th e Reregistration of Endothall and Endothall Salts. Transmittal of 1 Study. 28 -Jan 2000 45039501 Toth, J. (1999) Immunochemical Method for Residues of Endothall in Water: Lab Project Number: KP - 023 - 00. Unpublished study prepared by Elf Atochem North Ameri ca, Inc. 74 p. {OPPTS 850.7100} 28 -Jan 2000 45088200 US EPA (2000) Submission of Toxicity and Environmental Fate Data in Support of the Registration of various Triazine and other Pesticides. Transmittal of 32 Studies. 12 - Apr2000 45088229 Hiltibran, R. (1967) Effect of Some Herbicides on Fertilized Fish Eggs and Fry. Trans. Am. Fish. Soc. 96:414 - 416. 12 - Apr2000 45146300 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in Support of the Reregistration of Endothall Acid and i ts Salts. Transmittal of 2 Studies. 19 -Jun 2000 45146301 Ussary, J. (2000) DES -I- CATE II: Magnitude of the Residue of Endothall on Potatoes: Final Report: Lab Project Number: KP - 98 - 22: 22A - 98: 22B - 98. Unpublished study prepared by Elf Atochem North Ameri ca, Inc. 202 p. {OPPTS 860.1500} 19 -Jun 2000 Ussary, J. (2000) DES -I- CATE II: Magnitude of the Residue of Endothall on Potato 45146302 Processing Fractions: Final Report: Lab Project Number: KP - 98 - 23: 44884: 23A - 98. Unpublished study prepared by Elf Atoc hem North America, Inc. 162 p. {OPPTS 19 -Jun 2000 860.1520} 45156000 Elf Atochem North America, Inc. (2000) Submission of Residue Data in Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 29 -Jun 2000 45156001 Gresham, M . (2000) Analysis for Residues of Endothall Using HPLC- MSD: Lab Project Number: KP - 98 - 49: 44280. Unpublished study prepared by ABC Labs., Inc. 123 p. {OPPTS 860.1340} 29 -Jun 2000 45219000 Elf Atochem North America, Inc. (2000) Submission of Toxicity, Res idue Chemistry, Environmental Fate, Risk Assessment and Exposure Data in Support of the Petition for Tolerance of Endothall in/on Apples and Cotton. Transmittal of 2 Studies. 26 - Sep 2000 45219001 Davis, C. (2000) FQPA Supplemental Information on Endothal l Petition 7F4868: Endothall on Apples: Lab Project Number: FQPA 697F. Unpublished study prepared by Elf Atochem North America, Inc. 37 p. 26 - Sep 2000 45219002 Davis, C. (2000) FQPA Supplemental Information on Endothall Petition 7F4867: 26 - Sep 

### 103Endothall on Cott onseed: Lab Project Number: FQPA 697E. Unpublished study prepared 2000 by Elf Atochem North America, Inc. 41 p. 46421400 Cerexagri, Inc. (2004) Submission of Toxicology, Residue, Exposure and Risk Data in Support of the Petition for Tolerance of E ndothall in Fish. Transmittal of 3 Studies. 08 - Dec 2004 46421401 Eickhoff, J. (2004) Endothall: Acute and Chronic Dietary Exposure and Risk Assessment. Project Number: ENDOTHALL/2004/1. Unpublished study prepared by Toxcel LLC. 41 08 - Dec 2004 p. 46421402 Petty, D. (2004) Freshwater and Estuarine Finfish and Shellfish Consumption in the United States: Endothall. Project Number: NDR200403. Unpublished study prepared by NDR Research. 17 p. 08 - Dec 2004 Brookey, F. (2004) Independent Laboratory Valid ation of the Residue Analytical 46421403 Method: "Analysis for Residues of Endothall Using HPLC - MSD", Method No. KP218R0. Project Number: ML/04/1139/CRX, KP/2004/11, KP/218RO. Unpublished study 08 - Dec 2004 prepared by Morse Laboratories. 197 p. 92057000 Agchem Di vision - Pennwalt Corp. (1990) Reregistration Phase 3 Response: Endothall. 25 - May 1990 92057001 Shellenberger, T. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 00072455. Endothall Technical -- Single Dose Oral LD50 Value to Bobwhite Quail: Project W - 910. Prepared by Hazleton Laboratories America, Inc. 10 p. 25 - May 1990 92057002 Shellenberger, T. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 00035237. Hydrothol 191 -Acute Oral LD50 Test -Bobwhite Quail: Project No. 110 ­ 115. Prepared by Wildlife International Ltd. 11 p. 25 - May 1990 92057003 Shellenberger,T (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 00084613. Primary Eye Irritation of Endothal Granular to Rabbits: Project No. 867431. Prepared by Hazleton La boratories America, Inc. 12 p. 25 - May 1990 92057004 Shellenberger, T. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 40109204. Primary Dermal Irritation Study of Endothall Pelleted with the Rabbit: Project No. 480 - 2538. Prepared by American Biogenics Corporation. 8 p. 25 - May 1990 Plankenhorn, L. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 92057005 41040301. Combined Chronic Toxicity and Carcinogenicity Study of Disodium Endothall in Rats: Project HLA 6120 - 110. Prepared b y Hazleton Laboratories America, 25 - May 1990 Inc. 11 p. 92057006 Shellenberger, T. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 40745202. Chronic Feeding in the Rodent Endothall in the Non - Rodent: Project IRI 632934. Prepared by Inveresk Research International. 12 p. 25 - May 1990 92057007 Shellenberger, T. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 40685301. Oncogenicity Feeding Study of Disodium Endothall in Mice: Project No. WIL - 75009. Prepared by WIL Research Labora tories. 15 p. 25 - May 1990 92057008 Plankenhorn, L. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 00069054. Activity of the Endothall in the Salmonella/Microsomal Assay for Bacterial Mutagenicity: Project MA 1604.102. Prepared by Microbiol ogical Associates. 8 p. 25 - May 1990 92057009 Plankenhorn, L. (1990) Agchem Division - Pennwalt Corp. Phase 3 Reformat of MRID 00069054. Activity of Endothall in the Salmonella/Microsomal Assay for Bacterial Mutagenicity: Project MA 1604.102. Prepared by Mi crobiological Associates. 17 p. 25 - May 1990 92057999 Agchem Division - Pennwalt Corp. (1990) Reregistration Phase 3 Response: Endothall. 25 - May 

### 1041990 Correspondence and Supporting Material.



### 105

### Bibliography Citations for Endothall Dipotassium Salt MRID Cita tion Receipt Date 26244 Miller, C.W.; Lowe, J.I. (19) Toxicity of Herbicides to Estuarine Animals. (U.S. Bureau of Commercial Fisheries, unpublished report.) 05 -Jan 1968 Davis, J.T.; Hughes, J.S. (1963) Further Observations on the Toxicity of Comm ercial 30123 Herbicides to Bluegill Sunfish. (Unpublished study received Jan 2, 1980 under 2217 - 641; prepared by Louisiana, Wild Life and Fisheries Commission, submitted by PBI -Gordon 02 -Jan 1980 Corp., Kansas City, Kans.; CDL:241577 - S) 32379 Pomeroy, R.D. (1 969) Sulfide Controls, Application and Mechanics. (Unpublished study received Sep 23, 1969 under 9993 - 2; prepared by Pomeroy, Johnston and Bailey and others, submitted by Airrigation Engineering Co., Carmel Valley, Calif.; CDL:026359- I) 23 - Sep 1969 Baldridge, D.E.; Orsenigo, J.R.; Furtick, W.R.; et al. (1962) Weed Control Using Endothal 32901 Derivatives Applied on Sugar Beets and Other Field Crops. (Unpublished study received Apr 12, 1962 under 4581 - 204; prepared by Montana State College, Agricultural Ex periment Station, Huntley Branch Station and others, submitted by Pennwalt Corp. Agchem Div., 12 - Apr1962 King of Prussia, Pa.; CDL: 110608 - A) 35236 Pennwalt Corporation (1975) Fish and Wildlife Safety. (Unpublished study received Jan 5, 1978 under 1F110 5; CDL:096705 - A) 05 -Jan 1978 Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Eight - Day Dietary LC50 -- Bobwhite 35238 Quail: Project No. 110- 111. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Wildlife International, Ltd. in coop eration with Washington College, submitted 05 -Jan 1978 by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096705 - C) Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Eight - Day Dietary LC50 -- Mallard 35239 Duck: Project No. 110 - 113. (Unpublish ed study received Jan 5, 1978 under 1F1105; prepared by Wildlife International, Ltd. in cooperation with Washington College, sub 05 -Jan 1978 mitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096705 - D) Vilkas, A.G. (1977) The Acute T oxicity of Aquathol K to the Fiddler Crab,Uca pugilator: 35243 UCES Project # 11506- 41 - 04. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Agchem Div., King of 05 -Jan 1978 Prussia, Pa.; CDL:096705 - H) 35245 Pennwalt Corporation (1970) Beneficial Insect Safety. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096705 - K) 05 -Jan 1978 35427 Pennwalt Corporation Product Chemistry: Data Requirements. (Unpublished study received Jan 5, 1978 u nder 1F1105; CDL: 096703 - A) 05 -Jan 1978 35433 Pennwalt Corporation (1977) Stability of the Dipotassium Salt of Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - H) 05 -Jan 1978 35442 Pennwalt Corporation (1974) Results of Resid ue Determinations: Disappearance of Endothall in Water. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - S) 05 -Jan 1978 35443 Pennwalt Corporation (1974) Results of Residue Determinations: Fish and Other Aquatic Organisms (Oysters, Clams, Crayfish, etc.). (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - T) 05 -Jan 1978 35453 Pennwalt Corporation (1954) Toxicology:Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - AE) 05 -Jan 1978 

### 10636529 Carlson, R. E.; Sandeno, J.L. (1970) Effect of Endothall on the Growth of Several Fungi. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704 - B) 05 -Jan 1978 Watson, J.D. (1970) The Res ults of Tests on the Amount of Residue Remaining including a 36531 Description of the Analytical Method Used:Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 19 78 CDL:096704 - F) Watson, J.D. (1972) The Results of Tests on the Amount of Residue Remaining, Including 36532 a Description of the Analytical Method Used:Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - G) Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, Including 36533 a Description of the Analytical Methods Used:Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; submitted b y Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - H) Serns, S.L. (1977) Effects of Dipotassium endothall on rooted aquatics and adult and first 05 -Jan 36536 generation bluegills. Water Re - sources Bulletin 13(1):71 - 80. (Also in unpubli shed submission received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem 1978 26 - Oct Div., King of Prussia, Pa.; CDL:096704 - K) 1978 36537 Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, Including a Descri ption of the Analytical Method Used:Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096704- L) 05 -Jan 1978 36539 Miller, H. (1975) Phytotoxicity: Phototoxicity to Irrigated Crops. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704- N) 05 -Jan 1978 36543 Latven, A.R. (1975) Aquathol K (N.B. 58 - 196- 4). (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by P ennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704 - S) 05 -Jan 1978 36545 Latven, A.R. (1975) Aquathol Granular (N.B. 58 - 196- 7). (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704- V) 05 -Jan 1978 Latven, A.R. (1976) Endothall Products, Dermal Toxicity after Limited Exposure. 36549 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submi tted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 05 -Jan 1978 096704- AB) Paa, H. (1976) Report to Pennwalt Corporation: Acute Dermal Toxicity Study with 36556 Herbicide 273 in Albino Rabbits: IBT No. 8530 -08497. (Unpublished study receivedJan 5, 1978 under 1F1105; prepared by Industrial Bio - Test Laboratories, Inc., submitted by 05 -Jan 1978 Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704 - AI) Wise, M.T. (1977) Acute Inhalation Toxicity of a) Aquathol K (N.B. 77- 100 - 4) b) 26 -Jul Hydrothol 191 Liquid (N.B. 77- 100 - 2) c) Hydrothol 47 Liquid (N.B. 77- 100 - 3) d) Aquathol 1977 36561 (N.B. 77 - 99 - 7) e) Des -I- Cate Accelerate (N.B. 77 - 99 - 6) f) Knox - Out 2 FM (N.B. 4414- 94): Laboratory Nos. a) 7E - 5660 b) 7E - 5665 c) 7E - 5670 d) 7E - 5675 e) 7E - 5680 f) 7E - 5685. 04 - Oct 1977 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, 05 -Jan Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704- AO) 1978 36566 Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Aquathol K (N.B. 77- 100 - 4) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5658. (Unpublished study 05 -Jan 1978 

### 107received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div ., King of Prussia, Pa.; CDL:096704- AT) Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Aquathol K 36567 (N.B. 77 - 100- 4) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits: Laboratory No. 7E - 5659. (U npublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div.; King of Prussia, 05 -Jan 1978 Pa.; CDL: 096704 - AU) 36568 Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: La boratory No. 7E - 5656. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704- AW) 05 -Jan 1978 Pierre, F.S.; Parke, G.S.E. (1977) Report : A Primary Dermal Irritation Study of Aquathol 36573 Granular (N.B. 77 - 99 - 4) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits: Laboratory No. 7E - 5689. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., subm itted by Pennwalt Corp., Agchem Div., King 05 -Jan 1978 of Prussia, Pa.; CDL: 096704 - BB) Becker, J.; Parke, G.S.E. (1977) Report; The Effects of Aquathol Granular (N.B. 77- 99 - 4) 36574 on Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5688. (U npublished study received Jan 5, 1980 under 1F1105; prepared by Cannon Laboratories, Inc., submitted 05 -Jan 1978 by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704 - BC) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Aquathol Granular 36575 (N.B. 77 - 99 - 4) on New Zealand Albino Rabbits: Laboratory No. 7E - 5687. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted 05 -Jan 1978 by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704 - BD) 36576 Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E - 5686. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704- BE) 05 -Jan 1978 Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77 - 99 - 4) 2. 36592 Hydrothol 191 Granular (N.B. 77-99 - 2) 3. Hydrothol 47 Granular (N.B. 77- 99 - 3) 4. Hydout (N.B. 77- 99 - 5): Laboratory Nos . 1. 7E - 5690 2. 7E - 5695 3. 7E - 5700 4. 7E - 5705. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, 05 -Jan 1978 Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704- BU) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Aquathol K (N.B. 77­ 37847 100 - 4) on New Zealand Albino Rabbits: Laboratory No. 7E - 5657. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by 05 -Jan 1978 Pennwalt Corp., Ag chem Div., King of Prussia, Pa.; CDL: 096704 - AV) 40959 Eibert, J., Jr. (1966) Acute Oral Toxicity (LD50) Study in Rats: S.A. No. 106319. (Unpublished study received Apr 10, 1966 under 6G0503; prepared by Scientific Associates, Inc., submittedby Pennwalt Chemical Corp., Bryan, Tex.; CDL:090587 - B) 10 - Apr1966 40984 Pennsalt Chemical Corporation (1964) Analysis of Endothall in Water by Gas - Liquid Chromatography. Method dated Apr 27, 1964. (Unpublished study received Apr 10, 1966 under 6G0503; CDL: 090587 - AB) 10 - Apr1966 Davis, J.T.; Hughes, J.S. (1963) Further observations on the toxicity of commercial 41149 herbicides to bluegill sunfish. Proceedings of the Southern Weed Control Conference:337- 340. (Also n unpublished submission received on unknown date under 8F0660; submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:094930 - M) 46269 Swabey, Y.H.; Schenk, C.F. (1963) Report on Algaecides and Aquatic Herbicides. (Ontario, Water Resources Commission, Laboratory Division, Biology Branch, u npublished study; 12 -Jan 1965 

### 108CDL:107773 - B) 14 - Apr1966 48110 Davis, J.T.; Hughes, J.S. (1963) Further Observations on the Toxicity of Commercial Herbicides to Bluegill Sunfish. (Louisiana, Wildlife and Fisheries Commission, unpublished study; CDL: 241577 - R) 02 -Jan 1980 Schreck, C.B.; Corning, R.V.; Berry, C.R.; et al. (1974) Aquatic Plant Control Using 48767 Herbicides in a Large Potable Water Supply Reservoir: Contract No. DACW65 - 74- C - 0013. Annual report for the period Jul 1, 1973 --Jun 30, 1974. (Inco mplete; Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and Wild -life Sciences for U.S. Dept. of the 22 - Aug 1977 Army, Corps of Engineers, unpublished study; CDL:231436 - C) Berry, C.R. (1974) The Toxicity of Diquat and Endothal t o Mammals and Fish: Contract 48768 No. DACW65 - 74- C - 0013. (Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Corps of Engineers, 22 - Aug 1977 unpublished study; CDL:231436- D) Berry, C.R. (1 974) Acute Toxicity of Diquat, Endothal, and a Mixture of the Two to 48769 Bluegill Sunfish: Contract No. DACW65 - 74 - C-0013. (Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Corps of 22 - Aug 1977 Engineers, unpublished study; CDL:231436- E) Berry, C.R. (1974) Effect of Diquat and Endothall Separately and Combined on Bluegill 48770 Ventilation Rate: Contract No. DACW65 - 74- C- 0013. (Virginia Polytechnic Institute and State Univ., Dept. of Fisherie s and Wildlife Sciences for U.S. Dept. of the Army, Corps of 22 - Aug 1977 Engineers, unpublished study; CDL:231436- F) 49752 Pennwalt Corporation (1976) Residue Results. (Unpublished study received Feb 14, 1977 under 4581 - 223; CDL:228035 - A) 14 - Feb 1977 49958 Pennwalt Corporation (1975) Toxicity of Rabbits to Aquathol K and Hydrothol 47. (Compilation; unpublished study received Oct 5, 1976 under 4581 - 173; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:226503 - C) 05 - Oct 1976 56036 White, R.L.; Bounds, R.L.; Lowman, F.G.; et al. (1967) Experimental Control of Submerged Vegetation in Clear Water Lakes: Federal Aid Project No. F - 2- R - 14. (Texas, Parks and Wildlife Dept., Wildlife Services, unpublished study; CDL:132475 - A) 25 -Jun 1971 56037 Crabtree, J.E. ; Lewis, L.D.; Singleton, J.R.; et al. (1967) Lake Marvin Aquatic Weed Control: Federal Aid Project No. F - 15 - D - 8. (Texas, Parks and Wildlife Dept., Wildlife Services, unpublished study; CDL:132475 - E) 25 -Jun 1971 58568 Pennwalt Corporation Endothall Techn ical. Tacoma, Wash.: Pennwalt. (Product data bulletin no. 13c; also in unpublished submission received Feb 1, 1975 under 3F1416; CDL:093785 - D) 01 - Feb 1975 Imlay, P. (1978) Report: The Acute Dermal LD50 of Disodium endothall on New Zealand 58720 Albino Ra bbits: Laboratory No. 7E - 9262. (Unpublished study received Oct 26, 1978 under 4581 - 282; pre -pared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., 26 - Oct 1978 Philadelphia, Pa.; CDL:235435 - B) Imlay, P. (1978) Report: The Acute Dermal LD5 0 of Dipotassium endothall on New 58721 Zealand Albino Rabbits: Laboratory No. 7E - 9263. (Unpublished study received Oct 26, 1978 under 4581 - 282; pre - pared by Cannon Laboratories, Inc., submitted by Pennwalt 26 - Oct 1978 Corp., Philadelphia, Pa.; CDL:235435 - C) Anon. (1966) Summary of Toxicity Studies with Endothal Formulations on Animals. 61097 (Unpublished study received on unknown date under unknown admin. no.; CDL:109 C890­ A) 

### 10961605 Anon. (1967) Acute Oral LDI50 Data for Aquatic Herbicides. (Un -published study received Nov 18, 1968 under unknown admin. no.; CDL:109792- A) 18 - Nov 1968 Latven, A.R. (1975) Toxicology Report for Pennwalt Agchem Division: Aquathol K (N.B. 61921 58 - 196- 4). (Unpublished study received Oct 5, 1976 under 4581 - 174; prepared by Phar macology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 05 - Oct 1976 CDL:227610 - E) 71130 Pennwalt Corporation (1979) Fish and Wildlife Safety Summary. Summary of studies 244131 - B through 222131 - R. (Unpublished study received Jan 23, 1981 under 4581 - 174; CDL:244131 - A) 23 -Jan 1981 Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Bluegill 71134 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506- 41 - 16. (Unpublished study received Jan 23, 1981 under 4581 - 174; prepared by Union Carbide Corp., submitted 23 -Jan 1981 by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - F) Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid 71138 Equivalent Lot No. ACC - 06M8 - 04, NB84 - 5 - 10 to the Water Fle a, Daphnia magna Straus: UCES Project No. 11506- 41 - 14. (Unpublished study received Jan 23, 1981 under 4581 ­ 174; pre -pared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; 23 -Jan 1981 CDL:244131 - J) Morton, H.L.; Moffett, J.O. ; MacDonald, R.H. (1972) Toxicity of herbicides to newly 23 -Jan 71149 emerged honeybees. Environmental Entomology 1(1):102 - 104. (also in unpublished submission received Jan 23, 1981 under 4581 - 04; submitted by Pennwalt Corp., 19 81 23 - Oct Philadelphia, Pa.; CDL:244128 - A) 1981 71445 Landskov, A.O. (1981) Letter sent to Letha Coenen dated Feb 23, 1981: Compatibility -- herbicide 273 tank mixes: Project No. WT - 2 -81. (Unpublished study received Mar 25, 1981 under 4581 - 223; submitted by Pennwalt Corp., Philadelphia, P a.; CDL:244661 - A) 25 - Mar1981 Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Bluegill 72457 Sunfish, Lepomis macrochirus~Rafinesque: UCES Project No. 11506- 41 - 16. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by 23 -Jan 1981 Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - F) 74308 Pennwalt Corporation (1980) Efficacy of Various Herbicides -- Sugar - beet. (Compilation; unpublished study received Mar 23, 1981 under ND 81/1; submitte d by North Dakota, State Laboratories & Consumer Affairs for Pennwalt; CDL:244874- A) 23 - Mar1981 74309 Pennwalt Corporation (1976) Residue Study - Sugar Beet. (Compilation; unpublished study received Mar 23, 1981 under ND 81/1; submitted by North Dakota, State Laboratories & Consumer Affairs for Pennwalt; CDL:244874 - B) 23 - Mar1981 Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology reports 78180 on seven products. (Unpublished study received Jan 5, 1978 under 4581 - 174; preparedby Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 05 -Jan 1978 CDL:232580 - B) Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Aquathol K (N.B. 78183 58 - 196- 4). (Unpublished study received Jan 5, 1978 unde r 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 05 -Jan 1978 232580 - E) Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Aquathol Granular 78186 (N.B. 58 - 196- 7). (Unpublished stu dy received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Re -search, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 05 -Jan 1978 CDL:232580 - H) 

### 110Latven, A.R. (1976) Toxicology Report for Pennwalt, Agchem Division: Endothall 78192 Products, De rmal Toxicity after Limited Expo -sure. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt 05 -Jan 1978 Corp., Philadelphia, Pa.; CDL:232580 - O) Paa, H. (1976) Report to Pennwalt Cor poration: Acute Dermal Toxicity Study with 78198 Herbicide 273 in Albino Rabbits: IBT No. 8530 -08497. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Industrial Bio - Test Laboratories, Inc., submitted by 05 -Jan 1978 Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - V) Wise, M.T. (1977) Acute Inhalation Toxicity of Aquathol K (N.B. 77- 100 - 4); Hydrothol 191 Liquid (N.B. 77- 100 - 2); Hydrothol 47 Liquid (N.B. 77- 100 - 3); Aquathol (N.B. 77- 99 - 78202 7); Des - i- cate Accelerate (N.B. 77 - 99 - 6); Knox - out 2 FM (N.B. 4414 - 94): Laboratory Nos. 7E - 5660; 7E - 5665; 7F - 5670; 7E - 5675; 7E - 5680; 7E - 5685. (Unpublished study received Jan 05 -Jan 1978 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580 - AB) St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Aquathol K (N.B. 77- 100 - 4) on 78207 the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5658. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laborator ies, Inc., 05 -Jan 1978 submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580 - AG) St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Aquathol 78208 K (N.B. 77 - 100- 4) on Abraded and Non - abraded Skin of New Zealand Albin o Rabbits: Laboratory No. 7E - 5659. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 05 -Jan 1978 CDL:232580 - AH) 78209 Terrell, Y.; Parke, G.S.E. (1977) Report onOral LD50 in Rats: Aquathol K: Lab No. 7E 5656. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, PA; CDL:232580 - AJ) 05 -Jan 1978 St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Aquathol 78214 Granular (N.B. 77 - 99 - 4) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits: Laboratory No. 7E - 5689. (Unpublished study received Jan 5, 1978 under 4581 ­ 174; prepared by Cannon Laborator ies, Inc., submitted by Pennwalt Corp., Philadelphia, 05 -Jan 1978 Pa.; CDL:232580 - AO) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Aquathol Granular 78215 (N.B. 77 - 99 - 4) on New Zealand Albino Rabbits: Laboratory No. 7E - 5687. (Unpubli shed study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., 05 -Jan 1978 submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580 - AQ) 78216 Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E - 5686 . (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - AR) 05 -Jan 1978 Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77 - 99 - 4); 2. 78610 Hydrothol 191 Granular (N.B. 77- 99 - 2); 3. Hydrothol Granular (N.B. 77- 99 - 3); 4. Hydout (N.B. 77 - 99 - 5): Laboratory Nos. 7E - 5690; 7E -5695; 7E - 5700; 7E - 5705. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratorie s, Inc., 05 -Jan 1978 submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - BH) 80437 Pennsalt Chemicals Corporation (1954) Full Reports of Investigations Made with Respect to the Safety of the Product. (Unpublished study received Feb 4, 1966 under 6 G0503; CDL:090585 - B) 04 - Feb 1966 10 -Jun 1966 81397 Pennwalt Corporation (1966) Toxicological Investigations, Mammals: Summary. Summary 14 - Apr

### 111of studies 051133 - B through 051133 - M and 051133 - R. (Unpublished study received Apr 1966 14, 1966 under 4581 -70; CDL:051133 - A) 81407 Eibert, J., Jr. (1966) Acute Oral Toxicity (LDI50) Study in Rats: S.A. No. 106319. (Unpublished study received Apr 14, 1966 under 4581 - 70; prepared by Scientific Associates, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:0 51133 - K) 14 - Apr1966 Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Rainbow Trout, 83025 Salmo gairdneri Richardson: UCES Project No. 11506 - 41 - 15. (Unpublished study received Jan 23, 1981 under 4581 - 174; prepared by Union Carbi de Corp., submitted by Pennwalt 23 -Jan 1981 Corp., Philadelphia, Pa.; CDL:244131 - C) 83032 Pennwalt Corporation (1979) Fish and Wildlife Safety: Summary. (Unpublished study received Mar 25, 1981 under 4581 - 223; CDL: 244664- A) 25 - Mar1981 25 - Mar83033 Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 244662 - B. (Unpublished study received Mar 25, 1981 under 4581 - 223; CDL:244662 - A) 1981 14 - Sep 1981 83034 Pennwalt Corporation (1979) Drift of Endothall Sprays and Their Phytotoxi c Effects on Non - target Plant Species: Project No. WT -8 - 78. (Unpublished study received Mar 25, 1981 under 4581 - 223; CDL:244662 - B) 25 - Mar1981 Vilkas, A.J.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Rainbow Trout, 83106 Salmo gairdneri Richardson: UCES Project No. 11506 - 41 - 15. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt 23 -Jan 1981 Corp., Philadelphia, Pa.; CDL:099883 - C) Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid 83107 Equivalent Lot No. ACC - 06M8 - 04, NB84 - 5 - 10 to the Water Flea, Daphnia magna straus: UCES Project No. 11506- 41 - 14. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 198 1 under 1F1105; prepared by 23 -Jan 1981 Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - J) Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid 84150 Equivalent Lot No. ACC - 06M8 - 04, NB84 - 5 - 10 to th e Water Flea, Daphnia magna straus: UCES Project No. 11506- 41 - 14. (Unpublished study received Jan 23, 1981 under 4581 ­ 282; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; 23 -Jan 1981 CDL:244122 - J) 84601 Pennwalt Corporati on (19) Product Chemistry: Data Requirements. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL: 246016 - A) 14 - Sep 1981 84604 Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012- J through 246012- P. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL:246012 - B) 14 - Sep 1981 84605 Pennwalt Corporation (1975) Sub - acute Studies: Endothall. (Un - published study received Sep 14, 1981 under 4581 - 349; CDL: 246012 - C) 14 - Sep 1981 84608 Pennwalt Corporation (1979) Onc ogenicity Studies: Endothall. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL: 246012 - F) 14 - Sep 1981 84612 Ralston Purina Company (1981) Aquathol Granular Aquatic Herbicide: RT Lab No. 844059. (Unpublished study received Sep 14, 1981 under 4 581 - 349; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:246012 - J) 14 - Sep 1981 84614 Ralston Purina Company (1981) Aquathol Granular Aquatic Herbicide: RT Lab No. 844057. (Unpublished study received Sep 14, 1981 under 4581 - 349; submitted by Pennwalt 14 - Sep 1981 

### 112Corp., Philadelphia, Pa.; CDL:246012 - P) 84615 Pennwalt Corporation (1981) Efficacy of Endothal on Turf. (Compilation; unpublished study received Sep 14, 1981 under 4581 -349; CDL:246013 - A) 14 - Sep 1981 Landolt, M.L.; Felton, S.P.; Ligu ori, V.M.; et al. (1981) Toxicity of Endothall to Juvenile Chinook Salmon (Oncorhynchus tshawytscha). Final report (Washington, Dept. of Fisheries 84991 for U.S. Army Corps of Engineers, Waterways Experiment Station, Aquatic Plant Control Research Program; unpub lished study, including published data and letters dated Aug 5, 21 - Oct 1981 1981 from B.D. Gaughey to Gary Wedemeyer and Aug 27, 1981 from G.A. Wedemeyer to Bernalyn D. McGaughey; CDL:246080- A) Rosebery, G.D. (1981) Letter sent to Richard F. Mountf ort dated Jul 20, 1981 Aquathol K 86619 herbicide - Mutagenic and carcinogenic studies. Summary of studies 245680 - B through 245680 - D. (Unpublished study received Jul 29, 1981 under 4581 - 204; submitted by 29 -Jul 198 1 Pennwalt Corp., Philadelphia, Pa.; CDL:245680 - A) Vigfusson, N.V. (1981) Evaluation of the Mutagenic Potential of Aquathol by the Induction 86620 of Sister Chromatid Exchanges in Human Lymphocytes in Vitro. Final report. (Unpublished study received Jul 29, 1981 under 4581 - 204; prepared by Eastern Washi ngton Univ., Dept. 29 -Jul 1981 of Biology, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:245680 - B) Rundell, J.C.; Matthews, E.J. (1981) Evaluation of Aquathol K in the in Vitro 86621 Transformation of BALB/3T3 Cells with and without Metabolic Activ ation Assay: LBI Project No. 20992. Final report. (Unpublished study, including letter dated May 8, 1981 from J.W. Tapp to Neil Peterson, received Jul 24, 1981 under 4581 - 204; prepared by Litton 24 -Jul 1981 Bionetics, Inc., submitted by Pennwalt Corp., Philadelphia, P a.; CDL:245680- C) Folmar, L.C. (1976) Letter sent to Edward J. Bowles dated Jun 9, 1976 Results from 95812 toxicity tests conducted on rainbow trout fertilized eggs and sac fry with Aquathol K. (U.S. Fish and Wildlife Service, Bureau of Recla mation, Denver Fish - Pesticide Research Unit; 05 -Jan 1978 unpublished study; CDL:096705 - J) 96295 Walker, C.R. (1963) Letter sent to Harold L. Lindaberry dated Nov 8, 1963 Fish toxicity studies. (U.S. Fish and Wildlife Service, Fish Control Laboratory; unp ublished study; CDL:090719 - G) 23 - Mar1967 Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study 97831 No. 6915A. (Unpublished study received Sep 14, 1981 under 4581 - 349; prepared by Food and Drug Research Lab -oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 14 - Sep 1981 CDL:246012 - L) Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study 97832 No. 6915A. (Unpublished study received Sep 14, 1981 under 4581 - 349; prepared by F ood and Drug Research Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 14 - Sep 1981 CDL:246012 - M) Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study 97833 No. 6915A. (Unpublished study received Sep 14 , 1981 under 4581 - 349; prepared by Food and Drug Research Lab -oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 14 - Sep 1981 CDL:246012 - N) 99204 Applied Biochemists, Incorporated (1973) Toxicity Data for Copper -triethanolamine Complex on Ring - necked Pheasant and Mallard Duck. (Unpublished study received Nov 21, 1973 under 8959 - 12; CDL:010116- B) 21 - Nov 1973 99448 Schmidt, J. (1974) Subacute Toxicities of Cutrine and Weedtrine -Plus to Ring - necked Pheasants (Phasianus colchicus) & Mallard Ducks (Anus platyrhynchos): Dietary LC50. (Unpublished study received Jun 14, 1976 under 8959- 11; submitted by Applied Bio 14 -Jun 1976 

### 113chemists, Inc., Mequon, WI; CDL:224874- B) Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study 104758 No. 6915A. (Unpublished study received Sep 14, 1981 under 4581 - 349; prepared by Food and Drug Research Lab -oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 14 - Sep 1981 CDL:246012 - K) Pennwalt Corp. (1982) Report t o Pennwalt Corporation: Two - year Chronic Oral Toxicity 109473 and Carcinogenic Study with Dipotassium Endothal Monohydrate or Disodium Endothal in Albino Rats. (Compilation; unpublished study received Aug 12, 1982 under 1F1105; 12 - Aug 1982 CDL:071035 - A; 071036; 071037; 07103 8; 071039; 071040; 071041 071042; 071043) 113695 Davis, J.; Hughes, J. (1963) Further Observations on the Toxicity of Commercial Herbicides to Bluegill Sunfish. (Louisiana, Wild Life and Fisheries Commission; unpublished study; CDL: 098334 - F) 13 -Jun 1979 113932 Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Methods Used: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094703 - A; 094704) 09 -Jul 1975 113935 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. (Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094508- A) 01 - Dec 1970 113936 Pennwalt Corp. (1970) Name, Chemical Identity and Composit ion of Endothall. (Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094507- A) 01 - Dec 1970 113938 Pennwalt Corp. (1972) Toxicity Study: Endothall on Rats & Fish. Summary of studies 094506- C and 094506 - D. (Unpublished study received Ma y 31, 1972 under 1F1105; CDL:094506 - B) 31 - May 1972 113939 Van Duuren, B. (1972) Gastric Feeding in Rats: Beta - Propiolactone and Endothall. (Unpublished study received May 31, 1972 under 1F1105; prepared by New York Medical Center, submitted by Pennwalt C orp., Tacoma, WA; CDL:094506- C) 04 - May 1972 31 - May 1972 28 - Apr113953 Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method Used: Endothall. (Compilation; unpublished study received May 1 3, 1972 under 1F1105; CDL:094506- H) 1972 04 - May 1972 13 - May 1972 113959 Watson, J. (1971) Full Reports of Investigations Made with Respect to the Safety of the Product: Endothall. (Unpublished study received Aug 11, 1971 under 1F1057; submitted by Pennwalt Corp., Tacoma, WA; CDL:091892- A) 11 - Aug 1971 113971 Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of the Product: Endothall. (Compilation; unpublished study received on unknown date under 1F1105; CDL:09450 9 - A) 03 - May 1971 113987 Agchem (1970) The Results of Tests on the Amount of Residue Remain -ing Including a Description of the Analytical Method Used: Endothall. (Compilation; unpublished study received Jun 27, 1971 under unknown admin. no.; CDL:124882 - A ) 27 -Jun 1971 114487 Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and Complete Composition of the Product: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094700 - A) 09 -Jul 1975 11448 8 Pennwalt Corp. (1975) Full Reports and Data of Investigations Made on the Safety of the Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study 09 -Jul 1975 

### 114received Jul 9, 1975 under 1F1105; CDL:094702 - A) 114494 Folmar, L. (1 9) Letter sent to E. Bowles circa Dec 13, 1974 Aquathol K. (U.S. Dept. of the Interior, Bureau of Reclamation, Engineering and Research Center, Denver Fish Pesticide Unit; unpublished study; CDL:094702- K) 09 -Jul 1975 McCollum, K. (1973) Report to Pennwalt Corporation: 21 - day Sub -acute Oral Toxicity 114497 Study with Dipotassium Endothall and Disodium Endothall in Albino Rats: IBT No. 621 ­ 03463. (Unpublished study received Jul 9, 1975 under 1F1105; prepared by Industrial Bio 09 -Jul 1975 Test Laboratories, Inc., submi tted by Pennwalt Corp., Tacoma, WA; CDL:094702- N) Morrow, L. (1975) Report to ...: Two - year Chronic Oral Toxicity and Carcinogenic Study 114498 with Dipotassium Endothall Monohydrate or Disodium Endothall in Albino Rats: IBT No. 621 - 03115. (U npublished study received Jul 9, 1975 under 1F1105; prepared by Industrial 09 -Jul 1975 Bio - Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:094702- O) 114499 Pennwalt Corp. (1962) Chemical and Physical Properties: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094706 - A) 09 -Jul 1975 114500 Pennwalt Corp. (1975) Toxicity: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094706- B) 09 -Jul 1975 114501 Pennwalt Corp. (19 74) Residues: Endothall. (Unpublished study received Jul 9, 1975 under 1F1105; CDL:094706 - C) 09 -Jul 1975 114504 Pennwalt Corp. (1975) Duration of Biological Activity: Endothall. (Unpublished study received Jul 9, 1975 under 1F1105; CDL: 094706- F) 09 -Jul 1975 114505 Agchem (1954) Toxicological Investigations -- Mammals: Endothall. (Unpublished study received Mar 15, 1966 under 4581 - 139; CDL: 007441 - A) 15 - Mar1966 114511 Cope, O. (1965) Letter sent to E. Bowles dated Jul 23, 1965 Toxicity study of several Pennsalt herbicides against rainbow trout. (U.S. Fish and Wildlife Service, Fish - Pesticide Research Laboratory; unpublished study; CDL:007441 - K) 15 - Mar1966 114513 U.S. Fish and Wildlife Service, Fish Control Laboratory (19) Toxicity Study of Selected T est Chemicals on Rainbow Trout, Goldfish, Black Bullhead, and Bluegill. (Unpublished study; CDL:007441 - M) 15 - Mar1966 114525 Agchem (1963) Study: Endothall Breakdown in the Environment. (Compilation; unpublished study received Mar 15, 1966 under 4581 - 139 ; CDL:007441 - AD) 15 - Mar1966 Keckemet, O. (1963) Letter sent to Ag. Chem. File dated Feb 11, 1963: Microbiological 114526 breakdown of endothal weed killer & derivatives. (Unpublished study received Mar 15, 1966 under 4581 -139; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; 15 - Mar1966 CDL:007441 - AE) 114531 Agchem (1972) Toxicity of Endothall in Animals. Summary of studies 095336 - H, 094506­ C and 094506- D. (Unpublished study received May 4, 1972 under 4581 - 284; CDL:095336- C) 04 - May 1972 1 14540 Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15, 1970 under 0F0972; submitted by Pennwalt Corp., Tacoma, WA; CDL:095421 - F) 15 - Apr1970 114556 Carlson, R.; Sandeno, J. (1970) Effect of Endothall on the Growth of Several Fungi. (Unpublished study received Oct 26, 1978 under 4581 - 282; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:235432 - B) 26 - Oct 1978 116025 Pennwalt (1970) Endothal: Residues in Various Crops. (Compilation; unpublished study received on unknown date under 1F1105; CDL:090872- A) 

### 115Watson, J. (1972) Full Reports of Investigations Made with Respect to the Safety of the 116026 Pesticide Chemical: Endothall. Summary of studies 090872 - C through 090872- G. (Unpublished study received on unknown date under 1F1105; submitted by Pennwalt, Tacoma, WA; CDL:090872 - B) 116027 Duuren, B. (19) Gastric Feeding in Rats: beta - Propiolactone and Endothall. (Unpu blished study received Dec 27, 1961 under 1F1105; prepared by New York Medical Center, submitted by Pennwalt, Takoma, WA; CDL:090872- C) 27 - Dec 1961 Mixon, W. (1971) Endothall Residue in Goldfish -- Feeding Study. (Unpublished study 116028 received on unkno wn date under 1F1105; submitted by Pennwalt, Takoma, WA; CDL:090872 - D) 116457 Agchem (1962) Efficacy of Dipotassium Endothal. (Compilation; unpublished study received Jan 29, 1963 under 4581 - 200; CDL: 110609 - A) 29 -Jan 1963 116458 Rock, L. (1963) Letter sent to unknown recipient dated Jan 8, 1963 Potassium Endothal: Toxicity to fish. (Illinois, Dept. of Conservation; unpublished study; CDL:110609- B) 29 -Jan 1963 116471 McCann, J. (1969) Aquathol Plus Granular: Bluegill (Lepomis macrochirus). (U.S. Agr icultural Research Service, Pesticides Regulation Div., Animal Biology Laboratory; unpublished study; CDL:132041 - A) 18 - Apr1969 124622 Agchem (1970) Some Additional Information Pertaining to Fate of Endothall in the Environment: Summary. (Unpublished stu dy received Dec 1, 1970 under 1F1105; CDL:094511 - A) 01 - Dec 1970 Rodgers, J.; Reinert, K.; Hinman, M.; et al. (1983) Water Quality Monitoring in 137746 Conjunction with the Pat Mayse Lake Aquatic Plant Program. (Unpublished study received Mar 23, 1984 und er 4581 - 201; prepared by North Texas State Univ., Institute of Applied Sciences and Dept. of Biological Sciences, submitted by Agchem Div., Pennwalt Corp., 23 - Mar1984 Philadelphia, PA; CDL:252749- A) 138445 Mixon, W. (1971) Endothall Residue in Goldfish -- Feeding study. (Unpublished study received May 31, 1972 under 1F1105; submitted by Pennwalt Corp., Tacoma, WA; CDL:094506 - D) 04 - May 1972 31 - May 1972 138446 Serns, S. (1974) The Effects of a Dipotassium Endothall Treatment on the Ecology of a Small Pond . (Wisconsin, Dept. of Natural Resources, Water Resources Research Section; unpublished study; CDL:094702- J) 09 -Jul 1975 Folmar, L. (1976) Overt avoidance reaction of rainbow trout fry to nine herbicides. Bulletin 138964 of Environmental Contamination & Toxicology 15(5):509- 514. (Also In unpublished submission received Feb 6, 1984 under 239 - 2424; submitted by Chevron Chemical Co., 06 - Feb 1984 Richmond, CA; CDL:252355 - D) Folmar, L. (1978) Avoidance chamber responses of mayfly nymphs exposed to eig ht 138965 herbicides. Bulletin of Environmental Contamination & Toxicology 17:312 - 318. (Also In unpublished submission received Feb 6, 1984 under 239- 2424; submitted by Chevron 06 - Feb 1984 Chemical Co., Richmond, CA; CDL:252355 - E) 41037600 Pennwalt Corp. (19) S ubmission of Data To Support Registration of Endothall: Toxicology Data. Transmittal of 1 study. Strange, J. (1983) IBT Validation Report - Endothall Two - year Chronic Oral Toxicity and 41037601 Carcinogenic Study with Dipotassium Endothall Monohydrate or Disodium Endothall in Albino Rats: IBT No. 621 - 03115. Unpublished study prepared by Dynamac Corp. 8 p. 42289100 Atochem North America (1992) Submission of Data To Support Reregistration of 20 - Apr

### 116Endothall, K - Salt: Toxicology Studies. Transmittal of 6 studie s. 1992 42289101 Mallory, V. (1991) Acute Exposure Oral Toxicity in Rats with Pelletized Aquathol K: Lab Project Number: PH 402 - ANA - 008 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 42 p. 20 - Apr1992 42289102 Mallory, V. (1991) Acute Exposure Dermal Toxicity with Pelletized Aquathol K: Rabbits: Lab Project Number: PH 422 - ANA - 008 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 32 p. 20 - Apr1992 42289103 Mallory, V. (1991) Primary Eye Irritationwith Pelletized Aquathol K: Rabbits: Lab Project Number: PH 421 - ANA - 008- 91. Unpublished study prepared by Pharmakon Research International, Inc. 33 p. 20 - Apr1992 42289104 Mallory, V. (1991) Primary Dermal Irritation Study with Pelletized Aquathol K: Ra bbits: Lab Project Number: PH 420 - ANA - 008 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 27 p. 20 - Apr1992 42289105 Armondi, S. (1991) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with Pelletized Aquathol K: Lab Pro ject Number: PH 424- ANA - 007 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 56 p. 20 - Apr1992 42289106 Wang, W. (1991) Hydrolysis of carbon 14- Endothall Dipotassium Salt in Water at pH 5, 7 and 9: Final Report: Lab Project Number : XBL 91022: RPT0070. Unpublished study prepared by XenoBiotic Laboratories, Inc. 61 p. 20 - Apr1992 42338900 Atochem North America (1992) Submission of toxicity data to support the reregistration standard for Endothall (dipotassium salt). Transmittal of 5 studies. 01 -Jun 1992 42338901 Mallory, V. (1991) Acute Exposure Oral Toxicity in Rats with Aquathol K: Lab Project Number: PH 402 - ANA - 004- 91. Unpublished study prepared by Pharmakon Research Intl. 55 p. 01 -Jun 1992 42338902 Mallory, V. (1991) Acute E xposure Dermal Toxicity with Aquathol K: Lab Project Number: PH 422 - ANA - 004- 91. Unpublished study prepared by Pharmakon Research Intl. 32 p. 01 -Jun 1992 42338903 Mallory, V. (1991) Primary Eye Irritation with Aquathol K: Lab Project Number: PH 421 - ANA - 004 - 91. Unpublished study prepared by Pharmakon Research Intl., Inc. 32 p. 01 -Jun 1992 42338904 Mallory, V. (1991) Primary Dermal Irritation Study with Aquathol K: Lab Project Number: PH 420 - ANA - 004 - 91. Unpublished study prepared by Pharmakon Research Intl., Inc. 27 p. 01 -Jun 1992 42338905 Armondi, S. (1991) A Comparative Delayed Contact Hypersensitivity Study in Guinea Pigs (Buehler) with Aquathol K: Lab Project Number: PH 424 - ANA - 003 - 91. Unpublished study prepared by Pharmakon Research Intl., Inc. 76 p. 01 -Jun 1992 42359500 Atochem North America (1992) Submission of Toxicity Data in Supprot of Reregistration for Dipotassium Salt of endothall. Transmittal of 1 study. 17 -Jun 1992 42359501 Pedersen, C.; Helsten, B. (1992) Aquathol K Aquatic Herbicide: 2 1 - Day Acute Oral LD50 Study in Mallard Ducks: Lab Project Number: 106- 006 - 04. Unpublished study prepared by Bio - Life Associates, Ltd. 54 p. 17 -Jun 1992 42396400 Elf Atochem North America, Inc. (1992) Submission of toxicity data in support of the reregist ration of Dipotassium Salt of Endothall. Transmittal of 6 studies. 13 -Jul 1992 42396401 Hoberg, J. (1992) Dipotassium Salt of Endothall -- Toxicity to the Freshwater Bluegreen Alga Anabaena flosaquae: Final Report: Lab Project Number: 91 - 12 - 4035. Unpublish ed study prepared by Springborn Laboratories, Inc. 59 p. 13 -Jul 1992 

### 11742396402 Hoberg, J. (1992) Dipotassium Salt of Endothall -- Toxicity to the Freshwater Diatom Navicula pelliculosa: Final Report: Lab Project Number: 91 - 12 - 4049. Unpublished study prepare d by Springborn Laboratories, Inc. 61 p. 13 -Jul 1992 42396403 Hoberg, J. (1992) Dipotassium Salt of Endothall -- Toxicity to the Freshwater Green Alga, Selenastrum capricornutum: Final Report: Lab Project Number: 91 - 12 - 4053. Unpublished study prepared by S pringborn Laboratories, Inc. 61 p. 13 -Jul 1992 42396404 Hoberg, J. (1992) Dipotassium Salt of Endothall -- Toxicity to the Marine Diatom, Skeletonema costatum: Final Report: Lab Project Number: 92 - 1 - 4063. Unpublished study prepared by Springborn Laboratori es, Inc. 60 p. 13 -Jul 1992 Hoberg, J. (1992) Dipotassium Salt of Endothall -- Determination of Effects on Seed 42396405 Germination, Seedling Emergence and Vegetative Vigor of Ten Plant Species: Final Report: Lab Project Number: 91 - 11 - 4015: 12442.0391.6117 .610: BR - 91 - 55. Unpublished 13 -Jul 1992 study prepared by Springborn Laboratories, Inc. 353 p. 42396406 Hoberg, J. (1992) Dipotassium Salt of Endothall -- Toxicity to the Duckweed Lemna gibba: Final Report: Lab Project Number: 92 - 2- 4097: 12442.0391.6118.41 0: BR - 91 - 54. Unpublished study prepared by Springborn Laboratories, Inc. 45 p. 13 -Jul 1992 42407100 Atochem North America (1992) Submission of Toxicity Data in Support of the Reregistration of Aquathol K. Transmittal of 2 studies. 20 -Jul 1992 42407101 Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Aquathol K in the Rat: Lab Project Number: 91/8357. Unpublished study prepared by Bio/dynamics, Inc. 133 p. 20 -Jul 1992 42407102 Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Pelletized Aquathol K in the Rat: Lab Project Number: 91 - 8345: Unpublished study prepared by Bio/dynamics, Inc. 124 20 -Jul 1992 p. 42427600 Atochem North America (1992) Submission of exposure data in support of the Phase 4 requirements for Endothall. Transmittal of 1 study. 05 - Aug 1992 Baugher, D.; Meikle, S. (1992) Field Spray Drift Evaluation of Endothall (Accelerate 42427601 Herbicide) Results of Wind Tunnel Testing of Aerial and Airblast Application Nozzles: Lab Project Number: 32389: BR - 89 - 48: 55 - END/92028. U npublished study prepared by Orius 05 - Aug 1992 Associates, Inc. 152 p. 42495500 Elf Atochem North America, Inc. (1992) Submission of toxicity data in support of the reregistration of Endothall, K - Salt. Transmittal of 1 study. 02 - Oct 1992 42495501 Margi tich, D.; Ackerman, L. (1992) 21 Day Dermal Toxicity Study in Rats: Aquathol K: Lab Project Number: PH 430 - ANA - 002 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 330 p. 02 - Oct 1992 42618900 Atochem North America, Inc. (1993) Sub mission of environmental data in support of the data call - in for endothal acid. Transmittal of 1 study. 08 -Jan 1993 42618901 Reynolds, J. (1992) Aerobic Aquatic Metabolism of (carbon 14) - Endothall Dipotassium Salt: Lab Project Number: XBL 91024: RPT0083:BR - 91 - 46. Unpublished study prepared by XenoBiotic Labs, Inc. 81 p. 08 -Jan 1993 42629900 Elf Atochem N.A., Inc. (1993) Submission of product chemistry data in support of the data call - in for Endothall, K Salt. Transmittal of 1 study. 21 -Jan 1993 42629 901 Sweetapple, G. (1992) Dipotassium Endothall -- Color, Physical State, Odor, Melting Point, Bulk Density, pH: Lab Project Number: 4200 - 92 - 0335 - AS: 4200- 92 - 0335 - AS - 001. Unpublished study prepared by Ricerca, Inc. 36 p. 21 -Jan 1993 42644000 Atochem North America, Inc. (1993) Submission of environmental fate data to support 28 -Jan 

### 118Endothall reregistration. Transmittal of 1 study. 1993 42644001 Dionne, E. (1992) Dipotassium Salt of Endothall: Bioconcentration and Elimination of (carbon 14)- residues with Bl uegill Sunfish: Final Report: Lab Project Number: 92- 5 - 4269: 12442.0391.6115.140. Unpublished study prepared by Springborn Labs, Inc. 92 p. 28 -Jan 1993 42670100 Elf Atochem N.A., Inc. (1993) Submission of environmental fate data in support of the Endotha ll (K Salt) data call - in. Transmittal of 1 study. 18 - Feb 1993 42670101 Wright, J. (1993) Terrestrial Field Dissipation Studies for Endothall (Herbicide 273 Sugar Beet Herbicide) Applied to Sugar Beets: Lab Project Number: WT - 2 - 85: BR - 92- 53. Unpublished s tudy prepared by Pennwalt Corp. 223 p. 18 - Feb 1993 42695400 Elf Atochem (1993) Submission of toxicity data in support of the data call - in for Endothall, K Salt. Transmittal of 6 studies. 15 - Mar1993 Bettencourt, M. (1993) Aquathol K (Dipotassi um Salt of Endothall) -- Acute Toxicity to 42695401 Bluegill Sunfish (Lepomis macrochirus) under Flow - through Conditions: Final Report: Lab Project Number: 92 - 3 - 4192: 1244.0591.6133.105. Unpublished study prepared by 15 - Mar1993 Springborn Labs, Inc. 62 p. Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall) -- Acute Toxicity to 42695402 Rainbow Trout (Oncorhynchus mykiss) under Flow - through Conditions: Final Report: Lab Project Number: 92 - 3 - 4163: 12442.0591.6132.108. Unpublished study prepared by 15 - Mar1993 Springb orn Labs, Inc. 63 p. 42695403 Putt, A. (1993) Aquathol K (Dipotassium Salt of Endothall) -- Acute Toxicity to Daphnids (Daphnia magna) under Flow - through Conditions: Final Report: Lab Project Number: 92 - 3 - 4153: 12442.0591.6134.115. Unpublished study prepared by Springborn Labs, Inc. 69 p. 15 - Mar1993 Dionne, E. (1993) Aquathol K (Dipotassium Salt of Endothall)-- Acute Toxicity to Eastern 42695404 Oyster (Crassostrea virginica) under Flow - through Conditions: Final Report: Lab Project Number: 92 - 3 - 4149: 12442.0591.6137.504. Unpublished study prepared by Springborn 15 - Mar1993 Labs, Inc. 66 p. Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall) -- Acute Toxicity to 42695405 Sheepshead Minnow (Cyprinodon variegatus) under Flow - through Conditions: Final Report: Lab Project Number: 92 - 2- 4110: 12442.0591.6135.505. Unpublished study 15 - Mar1993 prepared by Springborn Labs, Inc. 64 p. Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall) -- Acute Toxicity to 42695406 Mysid Shrimp (Mysidopsis bahia) under Flow - through Conditions: Final Report: Lab Project Number: 92 - 9 - 4411: 12442.0591.6136.515. Unpublished study prepared by 15 - Mar1993 Springborn Labs, Inc. 66 p. 42787700 Elf Atochem North America, Inc. (1993) Submission of produ ct chemistry data in support of the reregistration for Endothall, K Salt. Transmittal of 2 studies. 26 - May 1993 42787701 Wojcieck, B. (1993) Aquathol Granular -- Color, Physical State, Odor, Bulk Density, pH: Lab Project Number: 4200 - 92 - 0178- AS: 4200- 92- 01 78 - AS - 001. Unpublished study prepared by Ricerca, Inc. 37 p. 26 - May 1993 42787702 Gallacher, A. (1993) Dipotassium Endothall -- Dissociation Constant: Lab Project Number: 4200- 92 - 0324- AS: 4200- 92- 0324- AS - 001. Unpublished study prepared by Ricerca, Inc. 54 26 - May 1993 p. 42792700 Elf Atochem North America, Inc. (1993) Submission of metabolism data in response to DCI for Endothall Acid (Technical). Transmittal of 2 studies 01 -Jun 1993 42792702 Reynolds, J. (1993) Aerobic Soil Metabolism of (carbon 14) - End othall Dipotassium Salt: 01 -Jun 

### 119Lab Project Number: XBL 91023: RPT00115: BR - 91 - 44. Unpublished study prepared by 1993 XenoBiotic Labs., Inc. 91 p. 42814100 Elf Atochem North America, Inc. (1993) Submission of additional range finding toxicity data in sup port of reregistration for Endothall K Salt. Transmittal of 1 study. 18 -Jun 1993 42814101 Margitich, D.; Ackerman, L. (1992) Aquathol K: 21 Day Dermal Toxicity Study in Rats: Lab Project Number: PH 430 - ANA - 001 - 91. Unpublished study prepared by Pharmakon Research International, Inc. 275 p. 18 -Jun 1993 42882500 Elf Atochem North America, Inc. (1993) Submission of Product Chemistry Data in Support of Reregistration of Endothall K Salt. Transmittal of 1 Study. 16 - Aug 1993 42882501 Wojcieck, B. (1993) Aquathol K: Color, Physical State, Odor, Specific Gravity, pH, Viscosity: Lab Project Number: 4200 - 92- 0176- AS: 4200 - 92- 0176 - AS - 001. Unpublished study prepared by Ricerca, Inc. 46 p. 16 - Aug 1993 42903900 Elf Atochem North America, Inc. (1993) Submission of Me tabolism Data for (Carbon 14)- Endothall Dipotassium Salt in Support of Reregistration. Transmittal of 1 Study. 31 - Aug 1993 42903901 Reynolds, J. (1993) Anaerobic Aquatic Metabolism of (Carbon 14C)- Endothall Dipotassium Salt: Lab Project Number: XBL 91025 : RPT00116: BR - 91 - 45. Unpublished study prepared by XenoBiotic Lab., Inc. 106 p. 31 - Aug 1993 43081800 Elf Atochem North America, Inc. (1993) Submission of product chemistry data in response to DCI for reregistration of endothall dipotassium salt. Transmi ttal of 2 studies. 11 -Jan 1994 43081801 Sweetapple, G. (1993) Aquathol K -- Corrosion Characteristics: Lab Project Number: 4200/92/0177/AS/001. Unpublished study prepared by Ricerca, Inc. 35 p. 11 -Jan 1994 43081802 Sweetapple, G. (1993) Aquathol Granular -- Corrosion Characteristics: Lab Project Number: 4200/92/0179/AS/001. Unpublished study prepared by Ricerca, Inc. 35 p. 11 -Jan 1994 43167800 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Aquathol K Aquatic Herbicide in Support of Reregistration Data Call - in. Transmittal of 2 studies. 22 - Mar1994 43167801 Pedersen, C. (1994) Aquathol K Aquatic Herbicide: 8 - Day Acute Dietary LC50 Study in Bobwhite Quail: Lab Project Number: 106 - 013 - 01: HWA 153 - 150. Unpublished study prepared by Bi o - Life Associates, Ltd. 102 p. 22 - Mar1994 43167802 Pedersen, C. (1994) Aquathol K Aquatic Herbicide: 8 - Day Acute Dietary LC50 Study in Mallard Ducklings: Lab Project Number: 106 - 017- 02: HWA 153 - 150. Unpublished study prepared by Bio - Life Associates, Ltd . 97 p. 22 - Mar1994 43264900 Elf Atochem North America, Inc. (1994) Submission of product chemistry (stability) data in support of reregistration of Endothall, K - salt. Transmittal of 1 study. 10 -Jun 1994 43264901 Malone, S. (1994) Dipotassium EndothallTG (B46 - 50): Stability: Lab Project Number: 4200/92/0327/AS/001. Unpublished study prepared by Ricerca, Inc. 57 p. 10 -Jun 1994 43299900 Elf Atochem North America, Inc. (1994) Submission of exposure assessment data in support of DCI for reregistration of endothall. Transmittal of 1 study. 12 -Jul 1994 43299901 Lunchick, C. (1994) Assessment of Worker Exposure and Margins of Exposure for Endothall Potassium and Amine Salt Formulation: Lab Project Number: EA070594. Unpublished study prepared by Jellinek, S chwartz & Connolly, Inc. 82 p. 12 -Jul 1994 43315800 Elf Atochem North America, Inc. (1994) Submittal of Environmental Fate Data in Support of Registration Standard for Endothall. Transmittal of 1 study. 26 -Jul 1994 43315801 Dionne, E. (1994) Metabolism of Endothall Dipotassium Salt in Bluegill Sunfish (Lepomis 26 -Jul 

### 120macrochirus): Identification and Characterization of Metabolites in Fillet and Viscera: Lab 1994 Project Number: 12442.0391.6115.180: BR - 91 - 53: 94 - 2 - 5168. Unpublished study prepared by Springborn Labs, Inc. and XenoBiotic labs Inc. 155 p. 43470100 Elf Atochem North America, Inc. (1994) Submission of Exposure Data in Support of Endothall Reregistration. Transmittal of 1 Study. 02 - Dec 1994 43470101 Lunchick, C. (1994) Assessment of Swimmer Exposure to Endothall in Aquathol-and Hydrothol-Treated Bodies of Water. Unpublished study prepared by Jellinek, Schwartz, and Connolly, Inc. 11 p. 02 - Dec 1994 43472800 Elf Atochem North America, Inc. (1994) Submission of Toxicity and Product Chemistr y Data in Support of the Reregistration of Endothall, Amine Salt. Transmittal of 3 Studies. 06 - Dec 1994 43472803 Lorence, P. (1994) Dipotassium Endothall -- Octanol/Water Partition Coefficient: Lab Project Numbers: 4200 - 92- 0256- AS: 4200- 92- 0256- AS - 001. Unp ublished study prepared by Ricerca, Inc. 51 p. 06 - Dec 1994 43551700 Elf Atochem North America, Inc. (1995) Submission of Product Chemistry Data in Support of the Reregistration of Dipotassium Salt of Endothall. Transmittal of 1 Study. 25 -Jan 1995 43551 701 Lorence, P. (1994) Dipotassium Endothall -- Solubility: Lab Project Numbers: 4200 - 92 - 0257- AS: 4200- 92- 0257- AS - 001: 4200 - 92 - 0257 - AS - 000. Unpublished study prepared by Ricerca, Inc. 67 p. 25 -Jan 1995 43873900 Elf Atochem North America, Inc. (1995) Submis sion of Product Chemistry Data in Support of the Amended Registrations of Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide. Transmittal of 2 Studies. 13 - Dec 1995 43873901 Lincks, G. (1994) Aquathol K Aquatic Herbicide Manufac turing Process: Lab Project Number: QC0006R0.QTR. Unpublished study prepared by Elf Atochem North America, Inc. 27 p. 13 - Dec 1995 43965300 Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in Support of the Amended Registration of HERBICIDE 273 Sugar Beet Herbicide. Transmittal of 1 Study. 29 - Mar1996 43965301 Lincks, G. (1994) Herbicide 273 Sugar Beet Herbicide Manufacturing Process: Lab Project Number: QC0008R0.QTR. Unpublished study prepared by Elf Atochem North America, Inc . 27 p. 29 - Mar1996 43966000 Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in Support of the Amended Registration of Aquathol Granular Aquatic Herbicide. Transmittal of 1 Study. 14 - Mar1996 43966001 Lincks, G.; Parker, J.; Wright, J. (1994) Aquathol Granular Aquatic Herbicide Manufacturing Process: Lab Project Number: QC0011R0.QTR. Unpublished study prepared by Elf Atochem North America, Inc. 23 p. 14 - Mar1996 44037400 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the Reregistration of Endothall and Salts. Transmittal of 2 Studies. 18 -Jun 1996 44037401 Ussary, J. (1996) Endothall: Magnitude of the Residue in Sugar Beet Processing Fractions: Final Report: Lab Project Number: BR - 90- 10: 53 - 90: 53A - 90. Unpublished study prepared by Elf Atochem North America, Inc.; McKenzie Labs; and Oaks Experimental Farm. 178 p. 18 -Jun 1996 44093400 Elf Atochem North America, Inc. (1996) Submission of Residue and Environmental Fate Data in Support of the R eregistration of Endothall and its Salts. Transmittal of 3 Studies. 26 - Aug 1996 44093402 Ritter, A.; Williams, W. (1996) Aquathol- K: The Rate of Dissipation of Endothall as a Result of Degradation versus Dilution: Lab Project Number: WEI 286.03: ATO BR - 94- 17: 26 - Aug 1996 

### 121BR - 94- 17. Unpublished study prepared by Waterborne Environmental, Inc.; Springborn Labs., Inc.; and McKenzie Labs. 225 p. 44093403 Biever, R. (1996) Aquathol K: An Aquatic Dissipation Study for Aquatic Non - Crop Uses: Lab Project Number:95 - 06 - 5898: 12442- 0894- 6181 - 330: BR - 94- 13. Unpublished study prepared by Springborn Labs., Inc. and McKenzie Labs., Inc. 375 p. 26 - Aug 1996 44263500 Elf Atochem North America, Inc. (1997) Submission of Metabolism and Residue Data in Support of the Rereg istration of Endothall and Salts. Transmittal of 8 Studies. 29 - Apr1997 44263502 Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Orange RAC: (Final Report): Lab Project Number: BR - 90 - 58: BR - 90- 58 - 1. Unpublished study prepared by McKenzi e Labs, Inc. 109 p. 29 - Apr1997 44263503 Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Tomato RAC: Lab Project Number: BR - 90 - 59: BR - 90- 59 - 1. Unpublished study prepared by McKenzie Labs, Inc. 105 p. 29 - Apr1997 44263504 Carr, B.; Amo s, L. (1997) Frozen Storage Stability of Endothall Residues in Broccoli RAC: (Final Report): Lab Project Number: BR - 90- 50: BR - 90- 50- 1. Unpublished study prepared by McKenzie Labs, Inc. 125 p. 29 - Apr1997 44263505 Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Rice RAC: (Final Report): Lab Project Number: BR - 90 - 51: BR - 90- 51 - 1. Unpublished study prepared by McKenzie Labs, Inc. 129 p. 29 - Apr1997 Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44263506 Treatment of Celery with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR - 91 - 02: 70 - 91: 29 - Apr1997 70A - 91. Unpublished study prepared by McKenzie Labs, Inc. 237 p. T oth, J.; Antle, P. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44263507 Treatment of Grapefruit with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: (Final Report): Lab Project Number: BR - 91 - 04: 74- 91: 74A - 91. 29 - Apr1997 Unpublished study prepared by McKenzie Labs, Inc. 224 p. Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44263508 Treatment of Peppers with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR - 91 - 05: 73 - 91: 29 - Apr1997 73A - 91. Unpublished study prepared by McKenzie Labs, Inc. 223 p. 44274400 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of the Reregistr ation for Endothall Acid & Salts. Transmittal of 1 Study. 29 - Apr1997 44274401 Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Spinach RAC: Lab Project Number: BR - 90 - 52: BR - 90- 52- 1. Unpublished study prepared by McKenzie Laboratories, I nc. 112 p. 29 - Apr1997 44319600 Elf Atochem North America, Inc. (1997) Submission of Product Chemistry and Toxicity Data in Support of the Application for Registration for Thin - Rite Blossom Thinner. Transmittal of 10 Studies. 03 -Jul 1997 44319601 Parke r, J. (1997) Thin - Rite Apple Blossom Thinner: Product Chemistry: (Product Identity and Composition): Lab Project Number: QC0018RO.QTR. Unpublished study prepared by Elf Atochem North America, Inc. 30 p. {OPPTS 830.1600, 830.1620, 830.1670} 03 -Jul 1997 44 319602 Parker, J. (1997) Thin - Rite Apple Blossom Thinner: Product Chemistry: (Physical and Chemical Characteristics). Unpublished study prepared by Elf Atochem North America, Inc. 5 p. 03 -Jul 1997 

### 122Wright, J. (1997) ThinRite -- Color, Physical Stat e, Odor, Density, and pH: (Draft Final 44319603 Report): Lab Project Number: QC9707A0.QTR: KP - 97 - 07. Unpublished study prepared by Elf Atochem North America, Inc. 32 p. {OPPTS 830.6302, 830.6303, 830.6304, 830.7300, 03 -Jul 1997 830.7000} 44319604 Wright, J. (1997 ) ThinRite -- Determination of Viscosity: (Draft Final Report): Lab Project Number: QC9712A0. QTR: KP - 97 - 12. Unpublished study prepared by Elf Atochem North America, Inc. 21 p. {OPPTS 830.7100} 03 -Jul 1997 44319605 Wnorowski, G. (1997) Acute Oral Toxicity Defined LD50 (in Rats): ThinRite: Lab Project Number: 5071: P320. Unpublished study prepared by Product Safety Labs. 25 p. 03 -Jul 1997 44319606 Wnorowski, G. (1997) Acute Dermal Toxicity Limit Test (in Rabbits): ThinRite: Lab Project Number: 5072: P322. Unpublished study prepared by Product Safety Labs. 16 p. 03 -Jul 1997 44319607 Wnorowski, G. (1997) Acute Inhalation Toxicity Limit Test (in Rats): ThinRite: Lab Project Number: 5076: P330. Unpublished study prepared by Product Safety Labs. 24 p. 03 -Jul 1997 44319608 Wnorowski, G. (1997) Primary Eye Irritation (in Rabbits): ThinRite: Lab Project Number: 5073: P324. Unpublished study prepared by Product Safety Labs. 22 p. 03 -Jul 1997 44319609 Wnorowski, G. (1997) Primary Skin Irritation (in Rabbits): Th inRite: Lab Project Number: 5074: P326. Unpublished study prepared by Product Safety Labs. 17 p. 03 -Jul 1997 44319610 Wnorowski, G. (1997) Dermal Sensitization Test -- Buehler Method (in Guinea Pigs): ThinRite: Lab Project Number: 5075: P328. Unpublished s tudy prepared by Product Safety Labs. 24 p. 03 -Jul 1997 44320100 Elf Atochem North America, Inc. (1997) Submission of Product Chemistry and Toxicity Data in Support of the Application for Registration of Aquathol Super K Granular Aquatic Herbicide. Trans mittal of 8 Studies. 03 -Jul 1997 44320101 Parker, J. (1997) Aquathol Super K Granular Aquatic Herbicide: Product Chemistry: Lab Project Number: QC0017R0.QTR. Unpublished study prepared by Elf Atochem North America. 25 p. {OPPTS 830.1620, 830.1670}. 03 -Jul 1997 44320102 Parker, J. (1997) Aquathol Super K Granular Aquatic Herbicide: Product Chemistry (Physical Chemical Characteristics). Unpublished study prepared by Elf Atochem North America. 5 p. 03 -Jul 1997 44320103 Gibson, K. (1997) Aquathol Super K -- Color, Physical State, Odor, Bulk Density, pH: Lab Project Number: QC9617A0.QTR: KP - 96 - 17. Unpublished study prepared by Elf Atochem North America, Inc. 28 p. {OPPTS 830.6302, 830.6303, 830.6304, 830.7300, 830.7000}. 03 -Jul 1997 44320104 Wnorowski, G. ( 1996) Acute Oral Toxicity Defined LD50 (in Rats): Aquathol Super K Granule: Lab Project Number: 4878: P320. Unpublished study prepared by Product Safety Labs. 26 p. 03 -Jul 1997 44320105 Wnorowski, G. (1996) Acute Dermal Toxicity Limit Test (in Rabbits): Aquathol Super K Granule: Lab Project Number: 4879: P322. Unpublished study prepared by Product Safety Labs. 15 p. 03 -Jul 1997 44320106 Wnorowski, G. (1996) Primary Eye Irritation (in Rabbits): Aquathol Super K Granule: Lab Project Number: 4880: P324. Un published study prepared by Product Safety Labs. 23 p. 03 -Jul 1997 44320107 Wnorowski, G. (1996) Primary Skin Irritation (in Rabbits): Aquathol Super K Granule: Lab Project Number: 4881: P326. Unpublished study prepared by Product Safety Labs. 16 p. 03 -Jul 1997 44320108 Wnorowski, G. (1996) Dermal Sensitization Test (in Guinea Pigs)-- Buehler Method: Aquathol Super K Granule: Lab Project Number: 4882: P328. Unpublished study prepared by Product Safety Labs. 24 p. 03 -Jul 1997 

### 12344320400 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of Petition for Tolerance for Endothall on Apples. Transmittal of 3 Studies. 03 -Jul 1997 Ussary, J. (1997) Endothall: Magnitude of the Residue in Apples Treated with TD- 2337, A 44320401 New Bloss om Thinner Use: Final Report: Lab Project Number: BR - 95 - 05: 05- 95: 05A - 95. Unpublished study prepared by Ussary Scientific Services, Inc.; ABC labs, Inc.; and Elf 03 -Jul 1997 Atochem N.A., Inc. 213 p. Leppert, B.; Sharp, J. (1997) Magnitude of R esidues of Endothall as TD - 2337- 03 Blossom 44320402 Thinner in Apple Processed Fractions: (Final Report): Lab Project Number: KP - 96 - 06: SARS - 96 - ID - 80: SARS - 96-WA - 80A. Unpublished study prepared by Stewart Agricultural 03 -Jul 1997 Services, Inc. and Elf Atochem N.A., Inc. 164 p . 44320403 Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number: FQPA 697E. Unpublished study prepared by Elf Atochem N.A., Inc. 42 p. 03 -Jul 1997 44334300 Elf Atochem N.A., Inc. (1997) Submission of Residue Data in Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 25 -Jul 1997 Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44334301 Treatment of Cabbage with Either Aquathol, Aquathol K , Hydrothol 191 Granular, or Hydrothol 191 Herbicides: Final Report: Lab Project Number: BR - 91 - 01: 71A - 91: 71B - 91. 25 -Jul 1997 Unpublished study prepared by Elf Atochem N.A., Inc. and McKenzie Labs, Inc. 241 p. 44343100 Elf Atochem North America, Inc. (1 997) Submission of Residue Data in Support of the Reregistration for Endothall Acid & Salts. Transmittal of 1 Study. 06 - Aug 1997 Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44343101 Treatment of Turnips with E ither Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: Lab Project Number: BR - 91 - 06: 72A - 91: 72B - 91. Unpublished 06 - Aug 1997 study prepared by McKenzie Laboratories, Inc. 237 p. 44392800 Elf Atochem N.A. Inc. (1997) Submission o f Effects of Pesticides on Non - Target Plants Data in Support of the Reregistration for Endothall Acid & Salts. Transmittal of 3 Studies. 01 - Oct 1997 Hoberg, J. (1997) Dipotassium Salt of Endothall -- Toxicity to the Freshwater Green Alga, 44392801 Selenast rum capricornutum: Supplemental Information to Final Report (MRID #423964 ­ 03): Lab Project Number: 91 - 12- 4053A: 12442.0391.6118.430A: BR - 91 - 58A. Unpublished 01 - Oct 1997 study prepared by Springborn Labs, Inc. 49 p. Hoberg, J. (1997) Dipotassium Salt of Endothall -- Toxicity to the Freshwater Diatom, 44392802 Novicula pelliculosa: Supplemental Information to Final Report (MIRD #426964 - 02): Lab Project Number: 91 - 12- 4049A: 12442.0391.6118.440A: BR - 91 - 57A. Unpublished study 01 - Oct 1997 prepared by Springborn Labs, Inc. 49 p. Hoberg, J. (1997) Dipotassium Salt of Endothall -- Determination of the Effects on Seed 44392803 Germination, Seedling Emergence and Vegetative Vigor of Ten Plant Species: Supplemental Information to Final Report (MIRD #423964 - 05): Lab Proj ect Number: 91 ­ 114015A: 12442.0391.6117.610A: BR - 91 - 55A. Unpublished study prepared by Springborn 01 - Oct 1997 Labs, Inc. 153 p. 44408800 ELF Atochem North America, Inc. (1997) Submission of Toxicology Data in Support of the Reregistration of Endothall Ac id and Salts. Transmittal of 1 Study. 27 - Oct 1997 Hoberg, J. (1997) Dipotassium Salt of Endothall -- Toxicity to the Freshwater Blue - Green 44408801 Alga, Anabaena flosaquae: Final Report: Lab Project Number: 91 - 12- 4035A: 12442.0391.6118.420A: BR - 91 - 56A. Un published study prepared by Springborn Labs, Inc. 27 - Oct 1997 46 p. 44557200 Elf Atochem North America, Inc. (1998) Submission of Product Chemistry Data in Support 04 - May 

### 124of the Application for Registration of Aquathol Super K Granular Aquatic Herbicide. 1998 Transm ittal of 1 Study. 44557201 Gitlitz, M. (1998) Particle Size and Friability of Granular Aquathol Super K Containing Fumed Silica as a Processing Aid: Lab Project Number: 10043. Unpublished study prepared by Elf Atochem North America Inc. 9 p. 04 - May 1998 44578400 Elf Atochem North America, Inc. (1998) Submission of Environmental Fate Data in Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 11 -Jun 1998 44578401 Mao, J. (1997) Endothall Amine Salt -- Determination of pH Dependent Hydrolysis: Lab Project Number: 12442.0396.6209.715: KP - 96 - 01: 96 - 6- 6537. Unpublished study prepared by Springborn laboratories, Inc. 79 p. 11 -Jun 1998 44608600 Elf Atochem North America, Inc. (1998) Submission of Residue Chemistry Da ta in Support of the Reregistration of Endothall Acids and Salts. Transmittal of 1 Study. 16 -Jul 1998 44608601 Fomenko, J. (1998) Evaluation of Endothall Through the FDA Multiresidue Methods: Lab Project Number: A036.50: KP - 97 - 18. Unpublished study prepared by Maxim Technologies, Inc. 63 p. {OPPTS 860.1360} 16 -Jul 1998 44820100 Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, Risk Assessment and Exposure Data in Support of the Reregistration of Endothall Acid and Salts. Transmitt al of 4 Studies. 05 - May 1999 Keckemet, O.; Sharp, J. (1999) Historical Aquatic Residue and Dissipation Data for 44820101 Endothall Aquatic Products Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: Lab Project Number: KP - 99 - 0 2: WT- 86- C- 11. Unpublished study 05 - May 1999 prepared by Elf Atochem. 316 p. {OPPTS 860.1400} Dionne, E.; Sharp, J.; Formella, T. (1999) Dipotassium Salt of Endothall: A Freshwater Fish 44820102 and Shellfish Magnitude of Residues Study in a Static Aquatic System: Lab Project Number: KP - 97 - 14: 52897/171.4/FIFRA: EN1115.95. Unpublished study prepared by Elf 05 - May 1999 Atochem and ABC Laboratories, Inc. 213 p. {OPPTS 860.1400} 44820103 Biever, R. (1998) Hydrothol 191: An Aquatic Dissipation Study for Aqu atic Non - Crop Uses: Final Report: Lab Project Number: KP - 96- 14: 98- 1 - 7215: 12442- 0896- 6214- 330. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 164 p. 05 - May 1999 44820104 Giddings, J. (1999) Ecological Risk Assessment of Aquatic Herbicides Containing Endothall: Final Report: Lab Project Number: KP - 98 - 31: 98- 11 - 7564: 12442 - 0898 - 6271 - 251. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 64 p. 05 - May 1999 44828800 Elf Atochem North America (1999) Subm ission of Environmental Fate Data in Support of the Reregistration of Endothall Acid and Salts Containing Products Aquathol K and Hydrothal 191. Transmittal of 2 Studies. 05 - May 1999 Singh, P.; Ritter, A.; Sharp, J. et al. (1999) Aquatic Dissipation Modeling of Endothall 44828801 Acid: Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: Lab Project Number: ATO KP - 97 - 16: WEI 286.01. Unpublished study prepared by 05 - May 1999 Waterborne Environmental, Inc. 363 p. William s, W.; Ritter, A.; Sharp, J. et al. (1999) An Evaluation of the Aquatic Dissipation of 44828802 Endothall Aquatic Product: Aquathol, K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: Lab Project Number: ATOKP - 98 - 32: WEI - 286.06. Unpublished 05 - May 1999 study prepared by Waterborne Environmental, Inc. 69 p. 44976700 Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the Reregistration of Endothall Acids and Salts Containing Product Hydrothol 191. Transmittal of 1 Stu dy. 20 - Oct 1999 

### 12544976701 Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191: A 96 - Hour Toxicity Test with the Marine Diatom (Skeletonema costatum): Final Report: Lab Project Number: 299A - 104. Unpublished study prepared by Wildlife International , Ltd. 38 p. {OPPTS 850.5400} 20 - Oct 1999 45031600 Elf Atochem North America, Inc. (2000) Submission of Product Chemistry Data in Support of the Application for Registration of Aquathol Super K Granular Aquatic Herbicide. Transmittal of 1 Study. 01 - Feb 20 00 45031601 Wright, J. (1998) Determination of Storage Stability and Corrosion Properties of Aquathol Super K: Final Report: Lab Project Number: KP - 96- 18: QC9618R0.QTR. Unpublished study prepared by Elf Atochem N.A. 24 p. {OPPTS 830.6317, 830.6320} 01 - Feb 2000 45039500 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in Support of the Reregistration of Endothall and Endothall Salts. Transmittal of 1 Study. 28 -Jan 2000 45039501 Toth, J. (1999) Immunochemical Method for Residue s of Endothall in Water: Lab Project Number: KP - 023 - 00. Unpublished study prepared by Elf Atochem North America, Inc. 74 p. {OPPTS 850.7100} 28 -Jan 2000 45146300 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in Support of th e Reregistration of Endothall Acid and its Salts. Transmittal of 2 Studies. 19 -Jun 2000 45146301 Ussary, J. (2000) DES -I- CATE II: Magnitude of the Residue of Endothall on Potatoes: Final Report: Lab Project Number: KP - 98 - 22: 22A - 98: 22B - 98. Unpublished s tudy prepared by Elf Atochem North America, Inc. 202 p. {OPPTS 860.1500} 19 -Jun 2000 Ussary, J. (2000) DES -I- CATE II: Magnitude of the Residue of Endothall on Potato 45146302 Processing Fractions: Final Report: Lab Project Number: KP - 98 - 23: 44884: 23A - 98 . Unpublished study prepared by Elf Atochem North America, Inc. 162 p. {OPPTS 19 -Jun 2000 860.1520} 45764300 Cerexagri, Inc. (2002) Submission of Risk and Exposure Assessment Data in Support of the Registration of Endothall Aquatic Herbicides. Transmitta l of 1 Study. 25 - Sep 2002 45764301 Davis, C.; Ampofo, S. (2002) Exposure and Risk Assessment for Persons Reentering Non Food Areas Treated with Endothall Aquatic Herbicides via Irrigation Water. Unpublished study prepared by Cerexagri, Inc. 26 p. 25 - Sep 2002 92060000 Agchem Division - Pennwalt Corp. (1990) Reregistration Phase 3 Response: Dipotassium endothall (7 - oxabicyclo(2.2.1)heptane - 2,3 - dicar. 26 - May 1990 92060001 Shellenberger, T. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 00084 614. Primary Eye Irritation of Aquathol Granular: Aquatic Herbicide to Rabbits: Project No. 844057.: 12 p. 26 - May 1990 92060999 Agchem Division - Pennwalt Corp. (1990) Reregistration Phase 3 Response: Dipotassium endothall (7 - oxabicyclo(2.2.1)heptane - 2,3 - d icar. Correspondence and Supporting Material. 26 - May 1990



### 126

### Bibliography Citations for Endothall N,N - dimethylalkylamine Salt MRID Citation Receipt Date 12112 Young, R.S. (1969) 1969 Report of Herbicide Field Trials. (Unpublished study received Jan 18, 1 973 under 100- 437; prepared by West Virginia Univ., submitted by Ciba - Geigy Corp., Greensboro, N.C.; CDL:000242 - G) 18 -Jan 1973 21918 Rhodia, Incorporated (1963) Weed Control Record Sheet: Project No. SAC - SAF- 1. (Unpublished study received Jul 24, 1964 un der 359 - 400; submitted by Rhone - Poulenc Chemical Co., Monmouth Junction, N.J.; CDL:023310 - A) 24 -Jul 1964 Inglis, A.; Davis, E.L. (1971) Technical Report on the Effect of Water Hardness on the Toxicity to Fish of Several Organic and Inorganic Herbic ides. (Unpublished study 28442 received Jul 13, 1971 under 1E1046; prepared by U.S. Fish and Wildlife Service, Div. of Fishery Research, Fish - Pesticide Research Laboratory in cooperation with National 13 -Jul 1971 Museum, Bird and Mammal Laboratory, submitted by U.S. Dept. o f the Army, Office of the Chief of Engineers, Washington, D.C.; CDL:091865 - G) 34907 Inglis, A.; Davis, E.L. (1965) The Effect of Water Hardness on the Toxicity to Fish of Several Organic and Inorganic Herbicides. (U.S. Fish and Wildlife Servi ce, Fish - Pesticide Research Laboratory, unpublished study; CDL:091752- A) 01 - Mar1972 Keckemet, O.; Seaman, D.E.; DeWitt, J.R. (1975) Substantive Amendment to Pesticide Petition No. 3F1416 (Also Designated as Pesticide Petition No. 4G1449-- Temporary 35235 Tolerance and Temporary Per -4581 - EXP - 18G and 4581 - EXP - 21G). (Unpublished study received Oct 21, 1975 under 4581 - EX - 18; prepared in cooperation with Univ. of 21 - Oct 1975 California, Rice Experiment Station and Occidental Chemical Co., submitted by Pennwalt Corp., Agc hem Div., King of Prussia, Pa.; CDL:096340 - D) 35236 Pennwalt Corporation (1975) Fish and Wildlife Safety. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096705 - A) 05 -Jan 1978 Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Acute Oral LD50 -- Bobwhite 35237 Quail: Project No. 110- 115. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Wildlife International, Ltd. in cooperation with Washington College, 05 -Jan 1978 submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096705- B) Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Eight - Day Dietary LC50 -- 35240 Bobwhite Quail: Project No. 110 - 112. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Wildlife International, Ltd. in c ooperation with Washington College, 05 -Jan 1978 submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096705 - E) Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Eight - Day Dietary LC50 -- Mallard 35241 Duck: Project No. 110 - 114. (Unpubl ished study received Jan 5, 1978 under 1F1105; prepared by Wildlife International, Ltd. in cooperation with Washington College, 05 -Jan 1978 submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096705 - F) Union Carbide Corporation (197 7) The Acute Toxicity of Hydrothol 191 to the Water 35242 Flea, Daphnia magna Straus: UCES Project # 11506 - 41 - 05. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, 05 -Jan 1978 Pa.; CDL:096705 - G) Vilkas, A.G. (1977) The Acute Toxicity of Hydrothol 191 to the Fiddler Crab, Uca 35 244 pugilator: UCES Project # 11506 - 41 - 05. (Un -published study received Jan 5, 1978 under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Agchem Div., 05 -Jan 1978 K

ing of Prussia, Pa.; CDL:096705 - I) 

### 12735245 Pennwalt Corporation (1970) Beneficial Insect Safety. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096705 - K) 05 -Jan 1978 35434 Pennwalt Corporation (19) Product Chemistry: Data Requireme nts. (Unpublished study received Jan 5, 1978 under 1F1105; CDL: 096703 - I) 05 -Jan 1978 35436 Pennwalt Corporation (1976) Analytical Procedure for Hydrothol 191 Liquid, Hydrothol 191 Granular (Hydrothol 191 Rice Herbicide), and Herbicide 283. Method dated Apr 1976. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - M) 05 -Jan 1978 35437 Whitaker, R.L. (1977) Product Stability. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096703 - N) 05 -Jan 1978 35438 Pennwalt Corporation (1977) Stability of the Mono(N,N - Dimethylcocoamine) Salt of Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - O) 05 -Jan 1978 35442 Pennwalt Corporation (1974) Results of Re sidue Determinations: Disappearance of Endothall in Water. (Unpublished study re -ceived Jan 5, 1978 under 1F1105; CDL:096703 - S) 05 -Jan 1978 35443 Pennwalt Corporation (1974) Results of Residue Determinations: Fish and Other Aquatic Organisms (Oysters, C lams, Crayfish, etc.). (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - T) 05 -Jan 1978 35453 Pennwalt Corporation (1954) Toxicology: Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703 - AE) 05 -Jan 1978 Seama n, D.E.; Berkenkotter, P.; Chen, T.M. (1966) Herbicide residues and submersed 35767 weed control in California rice fields. Pages 34 - 36, In Proceedings of the Rice Technical Working Group; Jun 14 - 17, 1966, Little Rock, Arkansas. N.P. (Also in unpublished submiss ion received Sep 19, 1971 under 1F1036; submitted by Monsanto Co., 19 - Sep 1971 Washington, D.C.; CDL:091921 - J) Wacker - Chemie, GmbH (1973) Migration Properties of the Pesticide. A translation of: 36530 Versickerungsverhalten des Pflanzenbehang -lungsmitte ls. (Unpublished study including German text and letter dated Apr 19, 1977 from Wacker - Chemie, GmbH to Dr. Louis, received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - D) Watson, J.D. (1970) Th e Results of Tests on the Amount of Residue Remaining including 36531 a Description of the Analytical Method Used: Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - F) Watson, J.D. (1972) The Results of Tests on the Amount of Residue Remaining, 36532 Including a Description of the Analytical Method Used: Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of 05 -Jan 1978 Prussia, Pa.; CDL:096704 - G) Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, 36534 Including a Description of the Analytical Methods Used: Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; sub mitted by Pennwalt Corp., Agchem Div., King of 05 -Jan 1978 Prussia, Pa.; CDL:096704 - I) 36535 Frank, P.A.; Comes, R.D. (1967) Herbicidal residues in pond water and hydrosoil. Weeds 15:210 - 213. (Also in unpublished submission received Jan 5, 1978 under 1F1 105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704- J) 05 -Jan 1978 21 - Oct 1982 

### 12836537 Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method Used: Endothal l. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096704- L) 05 -Jan 1978 36539 Miller, H. (1975) Phytotoxicity: Phototoxicity to Irrigated Crops. (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., Ki ng of Prussia, Pa.; CDL: 096704- N) 05 -Jan 1978 36542 Latven, A.R. (1975) Accelerate (N.B. 58- 196 - 3). (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704 - R) 05 -Jan 1978 Latven, A.R. (1976) Endothall Products, Dermal Toxicity after Limited Exposure. 36549 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 05 -Jan 1978 096704- AB) 36551 Latven, A.R. (1976) Hydout N.B. 77 - 23 - 6 (10.3% Endothall). (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., K ing of Prussia, Pa.; CDL:096704- AD) 05 -Jan 1978 36553 Latven, A.R. (1976) Accelerate N.B. 77 - 23 - 5 (5.5% Endothall). (Un - published study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704- AF) 05 -Jan 1978 Paa, H. (1976) Report to Pennwalt Corporation: Acute Dermal Toxicity Study with 36554 Hydrothol 191 in Albino Rabbits: IBT No. 8530 - 08497. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Industrial Bio - Test Laboratories, Inc., submitted by 05 -Jan 1978 Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704- AG) 36557 Latven, A.R. (1971) Accelerate. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704- AJ) 05 -Jan 1978 Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191 36558 Liquid (N.B. 77 - 100- 2) on New Zealand Albino Rabbits: Laboratory N o. 7E - 5662. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - AK) Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effec ts of Hydrothol 191 Liquid (N.B. 77 ­ 36559 100 - 2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5663. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - AL) Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E - 5661. 36560 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Co rp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL: 096704- AN) 36561 Wise, M.T. (1977) Acute Inhalation Toxicity of a) Aquathol K (N.B. 77- 100 - 4) b) Hydrothol 191 Liquid (N.B. 77- 100 - 2) c) Hydrothol 47 Liquid (N.B. 77- 100 - 3) d) Aquathol (N.B. 77 - 99 - 7) e) Des -I- Cate Accelerate (N.B. 77 - 99 - 6) f) Knox - Out(R)I 2 FM (N.B. 4414 - 94): Laboratory Nos. a) 7E - 5660 b) 7E - 5665 c) 7E - 5670 d) 7E - 5675 e) 7E 5680 f) 7E - 5685. (Un -published study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc. , submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704 - AO) 26 -Jul 1977 04 - Oct 1977 05 - Jan 1978 

### 129Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydrothol 36577 191 Granular (N.B. 77 - 99 - 2) on Abraded an d Non - abraded Skin of New Zealand Albino Rabbits: Lab -oratory No. 7E - 5694. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem 05 -Jan 1978 Div., King of Prussia, Pa.; CDL: 096704 - BF) Becker, J.; Parke, G.S.E. (1977) Report: The Effects of Hydro -thol 191 Granular (N.B. 36578 77 - 99 - 2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5693. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon L

aboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - BG) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LDI50 of Hydrothol 191 36579 Granular (N.B. 77 - 99 - 2) on New Zealand Albino Rabbits: La boratory No. 7E - 5692. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - BH) Terrell, Y.; Parke, G.S.E. (1977) Report o n Oral LD50 in Rats: Laboratory No. 7E - 5691. 36580 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL: 096704- BI) Pierre, F.S.; Park e, G.S.E. (1977) Report: The Effects of Hydout TM (N.B. 77- 99 - 5) on 36585 the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5703. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., 05 -Jan 1978 submitted by Pennwalt Cor p., Agchem Div., King of Prussia, Pa.; CDL: 096704- BN) Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydout 36586 TM (N.B. 77- 99 - 5) on Abraded and Nona -braded Skin of New Zealand Albino Rabbits: Laboratory N o. 7E -5704. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King 05 -Jan 1978 of Prussia, Pa.; CDL:096704- BO) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydout TM (N.B. 36587 77 - 99 - 5) on New Zealand Albino Rabbits: Laboratory No. 7E - 5702. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by 05 -Jan 1978 Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096707 - BP) Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E - 5701. 36588 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., Ki ng of Prussia, Pa.; 05 -Jan 1978 CDL: 096704- BQ) Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Des -I- Cate /Accelerate (N.B. 77­ 36589 99 - 6) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5678. (Unpublished study received Jan5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - BR) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Des -I36590 Cate/Accelerate (N.B. 7 7 - 99 - 6) on New Zealand Albino Rabbits: Laboratory No. 7E 5677. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 CDL:096704 - BS) 36591 T errell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E - 5676. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 05 -Jan 1978 

### 130CDL: 096704- B T) Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77 - 99 - 4) 2. Hydrothol 191 Granular (N.B. 77-99 - 2) 3. Hydrothol 47 Granular (N.B. 77- 99 - 3) 4. 36592 Hydout (N.B. 77- 99 - 5): Laboratory Nos. 1. 7E - 5690 2. 7E - 5695 3 . 7E - 5700 4. 7E - 5705. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 05 -Jan 1978 Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704- BU) Pierre, F.S.; Parke, G.S.E. (1977) Report : A Primary Dermal Irritation Study of Des -I37848 Cate /Accelerate (N.B. 77 - 99 - 6) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits: Laboratory No. 7E - 5679. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem 05 -Jan 1978 Div., King of Prussia, Pa.; CDL: 096704 - BZ) 40986 Bowles, E.J.; Keckemet, O; Boyle, W.D.; et al. (1964) Hydrothol 191 as an Aquatic Herbicide in Flowing Water. (Unpublished study received Apr 10, 1966 unde r 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587 - AE) 10 - Apr1966 42004 Carlson, R.E. (1966) Letter sent J.D. Watson dated Feb 11, 1966: Analysis of Mixtures of Amine Endothall with Def and Folex. (Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587 - AD) 10 - Apr1966 17 - Feb 1967 46489 Wakatsuki, J.; Wachi, G.; Oudman, L.; et al. (1975) Ripenthol Reports. (Reports by various sources; unpublished study received Oct 21, 1975 under 4581 - EX - 19; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:243211 - A) 21 - Oct 1975 49658 Pennwalt Corporation (1966) Toxicity Study: Hydrothal on Fish. (Reports by various sources; unpublished study received Jun 25, 1971 under unknown admin. n o.; CDL:132475 - F) 25 -Jun 1971 51466 Lapham, V.T. (1966) Letter sent to W. Harry Culver dated Jun 24, 1966 Fish Kills. (Louisiana, Wild Life and Fisheries Commission, Aquatic Vegetation Control Research, unpublished study; CDL:132475 - B) 25 -Jun 1971 5146 7 Frank, P.A. (1964) Letter sent to Edward J. Bowles dated Oct 30, 1964 Hydrothol treatment of aquatic weeds. (U.S. Agricul -tural Research Service, Crops Research Div., Crop Protection Research Branch, unpublished study; CDL:132475 - C) 25 -Jun 1971 51468 Zarbock, W.M. (1961) Letter sent to Harold Lindaberry dated Sep 20, 1961 TD191 on weeds and fish. (Ohio, Div. of Wildlife, Dept. of Natural Resources, unpublished study; CDL: 132475 - D) 25 -Jun 1971 51469 Brown, C.L. (1966) Letter sent to Edward Bowles dat ed Sep 22, 1966 Hydrothol on weeds and fish. (Glenn and Colusa Counties (California), Irrigation District, unpublished study; CDL:132475 - H) 25 -Jun 1971 Latven, A.R. (1975) Letter sent to Obren Keckemet dated Jun 26, 1975 Toxicological 05 - Oct 51589 findings withalcoholic Ripenthol and aqueous Ripenthol. (Unpublished study received Oct 5, 1976 under 4581 - 173; prepared by Pharmacology Research, Inc., submitted by 1976 05 -Jan Pennwalt Corp., Philadelphia, Pa.; CDL:226503 - B) 1978 Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydrothol 52457 191 Liquid (N.B. 77- 100 - 2) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits; Laboratory No. 7E - 5664. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem 05 -Jan 1978 Div., King of Prussia, Pa.; CDL: 096704 - AM) 52823 Seaman, D.E.; De Witt, J.R.; Beeman, H.D., Jr.; et al. (1975) Re -ports of Experimental 16 - Oct 

### 131Use of Hydrothol 119 Rice Herbicide. (Reports by various sources; unpublished study 1975 received Oct 16, 1975 under 4581 - EX - 21; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:243209 - A) 05 -Jan 1972 08 - Feb 55700 Frank, P.A.; Comes, R.D. (1967) Herbicidal residues in pond water and hydrosoil. Weeds 15(3):210- 2 13. (Also in unpublished sub -mission received Aug 4, 1976 under 876- 222; submitted by Velsicol Chemical Corp., Chicago, Ill.; CDL:229172 - F) 1973 04 - Aug 1976 22 - Aug 1977 21 - Dec 1982 56395 Hestand, R.S., III; Carter, C.C. (1967) Herbici de Effects on Aqua -tic Plants. (Unpublished study received Dec 19, 1975 under 6H5112; submitted by 3M Co., St. Paul, Minn.; CDL:230414- C) 19 - Dec 1975 56396 Hestand, R.S., III; Carter, C.C. (1968) Herbicide Effects on Phytoplankton. (Unpublished study re ceived Dec 19, 1975 under 6H5112; submitted by 3M Co., St. Paul, Minn.; CDL:230414 - D) 19 - Dec 1975 58566 Keckemet, O. (1973) The Name, Chemical Identity, and Composition of the Pesticide Chemical: Endothall. (Unpublished study received Feb 1, 1975 under 3 F1416; submitted by Pennwalt Corp., Tacoma, Wash.; CDL:093785 - A) 01 - Feb 1975 58567 Pennwalt Corporation (1973) Analytical Procedure for Hydrothol 191 and Hydrothol 191 Rice Herbicide. Method dated May 1973. (Un - published study received Feb 1, 1975 under 3F1416; CDL:093785 - C) 01 - Feb 1975 58569 Pennsalt Chemicals Corporation (1968) Product Specification 5 - 9224. (Unpublished study received Feb 1, 1975 under 3F1416; submitted by Pennwalt Corp., Tacoma, Wash.; CDL:093785 - E) 01 - Feb 1975 58570 Pennwalt Corp oration (1973) Efficacy of Hydrothol 191 on Rice. (Compilation; unpublished study, including published data, received Feb 1, 1975 under 3F1416; CDL:093785 - F) 01 - Feb 1975 Latven, A.R. (1971) Accelerate. (Unpublished study, including letter dated Sep 29, 1971 58572 from A.R. Latven to Harold L. Linda -berry, received Feb 1, 1975 under 3F1416; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, Wash.; 01 - Feb 1975 CDL:093785 - K) Latven, A.R. (1971) Accelerate. (Unpublished stu dy, including letter dated Oct 15, 1971 58573 from A.R. Latven to Harold L. Lindaberry, received Feb 1, 1975 under 3F1416; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, Wash.; 01 - Feb 1975 CDL:093785 - L) Keckemet, O. (1973) The Results of Tests on the Amount of Residue Remaining, 58574 Including a Description of the Analytical Method Used: Endothall. (Unpublished study received Feb 1, 1975 under 3F1416; submitted by Pennwalt Corp., Tacoma, Wash.; CDL: 01 - Feb 1975 093785 - M) Latven, A.R. (1975) Toxicology Report for Pennwalt Agchem Division: Ripenthol N.B. 61919 58 - 188 - 3 (Isopropyl -butanol Formulation). (Un -published study received Oct 5, 1976 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 05 - Oct 1976 Phi ladelphia, Pa.; CDL:227610 - C) 

### 132Latven, A.R. (1975) Toxicology Report for Pennwalt Agchem Division: Ripenthol N.B. 61920 58 - 191 - 2 (Water Only Formulation). (Unpublished study received Oct 5, 1976 under 4581 - 174; prepared by Pharmacology Researc h, Inc., submitted by Pennwalt Corp., 05 - Oct 1976 Philadel -phia, Pa.; CDL:227610 - D) Pennwalt Corporation (1975) Analytical Procedure for Hydrothol 191 Liquid (Ripenthol), 67024 Hydrothol 191 Granular (Hydrothol 191 Rice Herbicide) and Herbicide 283. Method dated Jan 1975. (Unpublished study received Feb 1, 1975 under 4581 - EX - 21; CDL: 01 - Feb 1975 094575 - C) 67025 Pennsalt Chemicals Corporation (1968) Hydrothol 191 Rice Herbicide: Product Specification 5 - 9224. (Unpublished study received Feb 1, 1975 under 4581 - EX - 21; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa., CDL:094575 - E) 01 - Feb 1975 67723 Pennsalt Chemical Corporation (1967) Chemical Data Regarding Des - i - cate. (Compilation; unpublished study received May 8, 1967 under 7G0608; CDL:0 92900- A) 08 - May 1967 Watson, J.D. (1967) The Results of Tests on the Amount of Residue Remaining, 67724 Including a Description of the Analytical Method Used: Des - i - cate. (Unpublished study received May 8, 1967 under 7G0608; submitted by Pennsalt Chemica l Corp., Agricultural 08 - May 1967 Chemicals Div., Aurora, Ill.; CDL:092900 - B) 67725 Watson, J.D. (1967) Reasonable Grounds in Support of the Petition: Des - i - cate. (Compilation; unpublished study received May 8, 1967 under 7G0608; submitted by Pennsalt Ch emical Corp., Agricultural Chemicals Div., Aurora, Ill.; CDL:092900 - C) 08 - May 1967 67763 Keckemet, O. (1975) Reasonable Grounds in Support of the Petition for Residue Tolerance: Endothall. (Unpublished study received Feb 1, 1975 under 4581 - EX - 21; submitt ed by Pennwalt Corp., Philadelphia, Pa.; CDL:094575 - F) 01 - Feb 1975 67764 Keckemet, O. (1975) Full Reports and Data of Investigation Made on the Effectiveness of the Product: Endothall. (Unpublished study received Feb 1, 1975 under 4581 - EX - 21; submitted b y Pennwalt Corp., Philadelphia, Pa.; CDL:094575- H) 01 - Feb 1975 69049 Pennwalt Corporation (1979) Phytotoxicity Summary. (Compilation; unpublished study received Jan 23, 1981 under 1F1105; CDL: 099882- A) 23 -Jan 1981 Moreno, M.T.; Moreno, O.M. (197 9) Test for Guinea Pig Sensitization: Project No. MB 69052 79 - 4140. (Unpublished study, including letter dated Dec 19, 1979 from O.M. Moreno to Obren Keckemet, received Jan 23, 1981 under 1F1105; prepared by MB Research 23 -Jan 1981 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099882 - D) Moreno, M.T.; Moreno, O.M. (1979) Test for Guinea Pig Sensitization: Project No. MB 70572 79 - 4140. (Unpublished study, including letter dated Dec 19, 1979 from O.M. Moreno to Obren Keckemet, received Jan 23, 1981 under 4581 - 204; prepared by MB Research 23 -Jan 1981 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244126- C) 71130 Pennwalt Corporation (1979) Fish and Wildlife Safety Summary. Summary of studies 244131 - B through 22213 1 - R. (Unpublished study received Jan 23, 1981 under 4581 - 174; CDL:244131 - A) 23 -Jan 1981 Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow 71132 Trout, Salmo gairdneri Richardson: UCES Project No. 11506- 41 - 17. (Unpublish ed study received Jan 23, 1981 under 4581 - 174; prepared by Union Carbide Corp., submitted by 23 -Jan 1981 Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - D) Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd -out(TM) Aquatic Weed 71133 Killer Code AHE 09H901, N.B. No. 84 - 112- 1 to the Rainbow Trout Salmo gairdneri Richardson: UCES Project No. 11506 - 41 - 20. (Unpublished study, including letters dated 23 -Jan 1981 Feb 7, 1980 from O. Keckemet to Agchem File and Jan 18, 1980 from A.G. Vilkas to 

### 133B.D. McGaughey, receiv ed Jan 23, 1981 under 4581 - 174; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - E) Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Bluegill 71135 Sunfish, Lepomis macroc hirus Rafinesque: UCES Project No. 11506- 41 - 18. (Unpublished study received Jan 23, 1981 under 4581 - 174; prepared by Union Carbide Corp., submitted 23 -Jan 1981 by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - G) Vilkas, A.G.; Seminara, J. (1979) Th e Acute Toxicity of Hyd -out(TM) Aquatic Weed Killer Code AHE 09H901, N.B. No. 84 - 112- 1 to the Bluegill Sunfish, Lepomis 71136 macrochirus Rafinesque: UCES Project No. 11506 - 41 - 19. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 23 -Jan 1981 4581 - 174; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - H) Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active) 71139 (Sample Code 84- 11 2 - 1; Lot AHE 09H9 - 01) to the Water Flea Daphnia magna Straus: UCES Project No. 11506- 41 - 22. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581 -174; prepared by 23 -Jan 1981 Union Carbide Corp., subm itted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - K) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient 71140 to the Grass Shrimp Palaemonetes pugio: USES Project No. 11506 - 41 - 23. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581 - 174; prepared by Union Carbide Corp., submitted by Pennwalt 23 -Jan 1981 Corp., Philadelphia, Pa.; CDL:244131 - M) Vilkas, A.G.; Seminara, J. (1979) T he Acute Toxicity of Hyd - out Aquatic Weed Killer Code AHE 09H901, N.B. No. 84 - 112 - 1 to the Fiddler Crab, Uca pugilator: UCES Project 71141 No. 11506 - 41 -24. (Unpublished study, including letters dated Jan 18, 1980 from A.G. Vilkas to B.D. McGaughey and Feb 7, 19 80 from O. Keckemet to Agchem File, received 23 -Jan 1981 Jan 23, 1981 under 4581 - 174; pre - pared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - N) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 2 2.6% Active Ingredient 71144 to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506- 41 - 21. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581 - 174; prepared by Union Carbide Corp., 23 -Jan 1981 submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131 - Q) Hestand, R.S., III (1974) Letter sent to Johnnie L. Frizzell dated Sep 27, 1974 Rough data 71146 on efficacy and toxicity of TD- 1874 and Hydrothol 191. (Florida, Game and Fresh Water Fish Comission; unpublished study, including letter dated Sep 26, 1974 from R.S. 23 -Jan 1981 Hestand, III to Johnnie L. Frizzell; CDL:244131 - T) 71147 U.S. Department of Interior, Bureau of Reclamation (1963) Results of Algaecidal Evaluation Tests of Selected Compounds: Report No. WC - 21. (Pages 26 - 32 only in Annual Progress Report of 1964 Lab. Studies; unpublished study; CDL:244131 - U) 23 -Jan 1981 71148 Pennwalt Corporation (1980) Hydout Aquatic Algicide and Herbicide -- Pellet State versus Toxicity: Project No. WT - 4 - 80. (Unpublished study received Jan 23, 1981 under 4581 ­ 174; CDL: 244131 - V) 23 -Jan 1981 71745 Pennwalt Corporation (1978) Residue Chemistry: Results of Residue Determinations. (Unpublished study received Jan 23, 1981 under 458 1 - 282; CDL:244121 - A) 23 -Jan 1981 71746 Pennwalt Corporation (1979) Hydout Aquatic Herbicide -- Release Rate: Project No. WT 13 - 79. (Unpublished study received Jan 23, 1981 under 4581 - 282; CDL:244121 - B) 23 -Jan 1981 

### 134Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow 72456 Trout, Salmo gairdneri Richardson: UCES Project No. 11506- 41 - 17. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by 23 -Jan 1981 Pennwalt Corp., Philadelphia, Pa.; CDL: 099883 - D) Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Bluegill 72458 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506- 41 - 18. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Un ion Carbide Corp.; submit -ted 23 -Jan 1981 by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - G) Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd - out Aquatic Weed Killer Code AHE 09H901, N.B. No. 84 - 112 - 1 to the Bluegill Sunfish Lepomis ma crochirus 72459 Rafinesque: UCES Project No. 11506- 41 - 19. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 1F1105; 23 -Jan 1981 prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - H) Vilkas, A.G.; Hughes, J.S. (1979) The Acute Toxicity of Endothall (Acid Monohydrate) 72460 to the Water Flea Daphnia magna Straus: UCES Project No. 11506 - 41 - 09. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted 23 -Jan 1981 by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - I) Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active) 72461 (Sample Code 84- 112 - 1; Lot AHE 09H9 - 01) to the Water Flea Daphnia magna St raus: UCES Project No. 11506- 41 - 22. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; 23 -Jan 1981 CDL:099883 - K) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxici ty of Hydout, 22.6% Active Ingredient 72462 to the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506- 41 - 23. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 1F1105; prepared by Union Car -b ide Corp., submitted by Pennwalt Corp., 23 -Jan 1981 Philadelphia, Pa.; CDL: 099883 - M) Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd - out Aquatic Weed Killer Code AHE 09H901, N.B. No. 84 - 112 - 1 to the Fiddler Crab, Uca pugilator: UCES Pr oject 72463 No. 11506 - 41 -24. (Unpublished study, including letters dated Feb 7, 1980 from O. Keckement to Agchem File and Jan 18, 1980 from A.G. Vilkas to B.D. McGaughey, 23 -Jan 1981 received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - N) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient 72466 to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506- 41 - 21. (Unpublished study,including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., 23 -Jan 1981 submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883 - Q) 72550 Pennwalt Corporation (1980) EfficacyIntroduction: Hydout Aquatic Algicide and Herbicide. (Compilation; unpublished study received Jan 23, 1981 under 4581 - EX - 32; CDL:244117 - A) 23 -Jan 1981 Moreno, M.T.; Moreno, O.M. (1979) Test for Guinea Pig Sensitiza -tion: Project No. MB 73370 79 - 4140. ( Unpublished study, including letter dated Dec 19, 1979 from O.M. Moreno to Obren Keckemet, received Jan 23, 1981 under 4581 - 174; prepared by MB Research 23 -Jan 1981 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244123 - C) 74221 Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active) (Sample Code 84- 112 - 1; Lot AHE 09H9 - 01) to the Water Flea Daphnia magna Straus: UCES Project No. 11506- 41 - 22. (Unpublished study, including letter dated Feb 7, 1980 23 -Jan 1981 

### 135from O. Keckem et to Agchem File, received Jan 23, 1981 under 4581 -282; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - K) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingred ient 74222 to the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506- 41 - 23. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581 - 282; prepared by Union Carbide Corp., submitted by Pennwalt 23 -Jan 1981 Corp., Philadelphia, Pa.; CDL:244122 - M) Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hy - dout Aquatic Weed Killer, Code AHE 09H901, N.B. No. 84 - 112- 1, to the Fiddler Crab, Uca pugilator: UCES 74223 Project No. 11506 - 41 - 24. (Unpubli shed study, including letters dated Jan 18, 1980 from A.G. Vilkas to B.D. Mc Gaughey and Feb 7, 1980 from O. Keckemet to Agchem File, 23 -Jan 1981 received Jan 23, 1981 under 4581 - 282; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - N) Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active 74226 Ingredient, to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506 - 41 - 21. (Unpublished study, including letter dated Feb 7 , 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581 - 282; prepared by Union 23 -Jan 1981 Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - Q) 74229 U.S. Department of the Interior, Bureau of Reclamation (1964) R esults of Algaecidal Evaluation Tests of Selected Compounds: Report No. WC - 21. (Unpublished study; CDL:244122 - U) 23 -Jan 1981 Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology 78180 reports on seven products. (Unpublished stu dy received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 05 -Jan 1978 Pa.; CDL:232580 - B) Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Accelerate (N.B. 78182 58 - 196- 3). (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 05 -Jan 1978 232580 - D) Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Rip enthol N.B. 78188 58 - 188 - 3 (Isopropyl -butanol Formulation). (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 05 -Jan 1978 Philadelphia, Pa.; CDL:232580 - K) Latven, A.R. (1975) Tox icology Report for Pennwalt, Agchem Division: Ripenthol N.B. 78189 58 - 191 - 2 (Water Only Formulation). (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 05 -Jan 1978 Philadelphia, Pa.; CDL:232580 - L) Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Ripenthol N.B. 78190 58 - 191 - 2 (23.4%). (Unpublished study, including letter dated Aug 14, 1975 from A.R. Latven to Obren Kechemet, received Jan 5, 1978 under 4581 - 174; prepar ed by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 05 -Jan 1978 CDL:232580 - M) Latven, A.R. (1976) Letter sent to Obren Keckemet dated Jan 29, 1976 Toxicological 78191 study reports on endothall products. (Un -published stud y received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 05 -Jan 1978 Philadelphia, Pa.; CDL:232580 - N) 78192 Latven, A.R. (1976) Toxicology Report for Pennwalt, Agchem Division: Endothall Products, Derma l Toxicity after Limited Expo -sure. (Unpublished study received Jan 5, 05 -Jan 1978 

### 1361978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - O) Latven, A.R. (1976) Toxicology Report Fo r Pennwalt, Agchem Division: Hydout N.B. 78194 77 - 23 - 6 (10.3% Endothall). (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 05 -Jan 1978 Pa.; CDL:232580 - Q) Latven, A .R. (1976) Toxicology Report for Pennwalt, Agchem Division: Accelerate N.B. 78196 77 - 23 - 5 (5.5% Endothall). (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 05 -Jan 1978 Pa.; CDL:23258 0 - S) 78199 Latven, A.R. (1971) Toxicology Report for Pennwalt Corporation: Ac -celerate. (Unpublished study received Jan 5, 1978 under 4581 -174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232 580 -W) 05 -Jan 1978 Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191 78200 Liquid (N.B. 77 - 100- 2) on New Zealand Albino Rabbits: Laboratory No. 7E - 5662. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Can non 05 -Jan 1978 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580 - X) 78201 Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab -oratory No. 7E - 5661. (Unpublished study received Jan 5, 1978 under 4581 - 174; prep ared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - AA) 05 -Jan 1978 Wise, M.T. (1977) Acute Inhalation Toxicity of Aquathol K (N.B. 77- 100 - 4); Hydrothol 191 Liquid (N.B. 77- 100 - 2); Hydrothol 47 Liquid (N.B. 77 - 100 - 3); Aquathol (N.B. 77­ 78202 99 - 7); Des - i- cate Accelerate (N.B. 77- 99 - 6); Knox - out 2 FM (N.B. 4414 - 94): Laboratory Nos. 7E - 5660; 7E - 5665; 7F - 5670; 7E - 5675; 7E - 5680; 7E - 5685. (Unpublished study 05 -Jan 1978 received Jan 5, 1978 under 4581 - 174; prepared by Cannon Labor atories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580 - AB) St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of 78217 Hydrothol 191 Granular (N.B. 77- 99 - 2) on Abraded and Non - abraded Skin of Ne w Zealand Albino Rabbits: Laboratory No. 7E - 5694. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt 05 -Jan 1978 Corp., Philadelphia, Pa.; CDL:232580 - AS) Becker, J.; Parke, G.S.E. (1 977) Report: The Effects of Hydrothol 191 Granular (N.B. 77­ 78218 99 - 2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5693. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon 05 -Jan 1978 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - AT) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191 78219 Granular (N.B. 77 - 99 - 2) on New Zealand Albino Rabbits: Laboratory No. 7E - 5692. (Unpublished study received Jan 5, 1 978 under 4581 - 174; prepared by Cannon 05 -Jan 1978 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580 - AU) 78220 Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab -oratory No. 7E - 5691. (Unpublished study recei ved Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - AV) 05 -Jan 1978 St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Hydout (N.B. 77 - 99 - 5) on the 78603 Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5703. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., 05 -Jan 1978 submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580 - BA) 78604 St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydout 05 -Jan 

### 137(N.B. 77 - 99 - 5) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits: 1978 Laboratory No. 7E -5704. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - BB) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydout (N.B. 77- 99 - 78605 5) on New Zealand Albino Rabbits: Laboratory No. 7E - 5702. (Unpublished study rece ived Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted 05 -Jan 1978 by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - BC) 78606 Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab -oratory No. 7E - 5701. (Unpublishedstudy received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - BD) 05 -Jan 1978 St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Des - i - cate /Accelerate (N.B. 78607 77 - 99 - 6) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5678. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon 05 -Jan 1978 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - BE) Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Des - i - cate 786 08 /Accelerate (N.B. 77 - 99 - 6) on New Zealand Albino Rabbits: Laboratory No. 7E - 5677. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon 05 -Jan 1978 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580 - BF) 78609 Terrell, Y; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E - 5676. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratori es, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - BG) 05 -Jan 1978 Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77 - 99 - 4); 2. 78610 Hydrothol 191 Granular (N.B. 77- 99 - 2); 3. Hydrothol 47 Granular (N.B. 77 - 99 - 3); 4. Hydout (N.B. 77- 99 - 5): Laboratory Nos. 7E - 5690; 7E -5695; 7E - 5700; 7E - 5705. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon 05 -Jan 1978 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580 - BH) St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Des - i 78614 cate /Accelerate (N.B. 77 - 99 - 6) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits: Laboratory No. 7E - 5679. (Unpublished study received Jan 5, 1978 u nder 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., 05 -Jan 1978 Philadelphia, Pa.; CDL:232580 - BM) Pennsalt Chemicals Corporation (1966) Summary of Justification: Disodium Endothall. 80436 Summary of studies 090585 - B through 090585 - F. (Unpublished study received on unknown date under 6G0503; CDL:090585 - A) 80438 Pennsalt Chemicals Corporation (1966) Endothall Residue -- Cotton. (Compilation; unpublished study received on unknown date under 6G0503; CDL:090585 - C) Carlson, R.E. (1966) Letter sent to J.D. Watson dated Feb 11, 1966: Analysis of mixtures 80440 of amine endothall with Def and Folex. (Unpublished study received on unknown date under 6G0503; submitted by Pennsalt Chemicals Corp., Tacoma, Wash.; CDL:090585 - F) 8 3032 Pennwalt Corporation (1979) Fish and Wildlife Safety: Summary. (Unpublished study received Mar 25, 1981 under 4581 - 223; CDL: 244664- A) 25 - Mar1981 25 - Mar83033 Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 244662 - B. (Unpubl ished study received Mar 25, 1981 under 4581 - 223; CDL:244662 - A) 1981 14 - Sep 1981 83034 Pennwalt Corporation (1979) Drift of Endothall Sprays and Their Phytotoxic Effects on 25 - Mar

### 138Non - target Plant Species: Project No. WT -8 - 78. (Unpublished study receive d Mar 25, 1981 1981 under 4581 - 223; CDL:244662 - B) Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow 84147 Trout, Salmo gairdneri Richardson: UCES Project No. 11506- 41 - 17. (Unpublished study, including letters dat ed Jan 18, 1980 from A.G. Vilkas to B.D. McGaughey and Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581 - 282; prepared 23 -Jan 1981 by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - D) Vil kas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Bluegill 84148 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506- 41 - 18. (Unpublished study received Jan 23, 1981 under 4581 - 282; prepared by Union Carbide Corp., submitted 23 -Jan 1981 by Pennwalt Corp., Philadelphia, Pa.; CDL:244122 - G) Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydout Aquatic Weed Killer Code AHE 09H901, N.B. No. 84 - 112- 1 to the Bluegill Sunfish Lepomis macrochirus 84149 Rafinesque: UCES Projec t No. 11506- 41 - 19. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581 - 282; 23 -Jan 198 1 prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: CDL:244122 - H) 84382 Seaman, D.E.; Berkenkotter, P.; Chen, T.M.; et al. (1966) Persistence of Residues and Fates of Herbicides in Rice Fields and in Rice - field Effluents: Progress report. WRC Project No. W 3 02 67. for the period Mar 1, 1965 to Jan 31, 1966. (Unpublis hed study received Oct 8, 1981 under 476 - 2107; prepared by Univ. of California -- Davis, Dept. of Botany, submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:246011 - M) 08 - Oct 1981 14 - Oct 1983 St. Pierre, F.; Parke, G.S.E. (1977) Report: The Eff ects of Hydrothol 191 Liquid (N.B. 77 ­ 84474 100 - 2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E - 5663. (Unpublished study received Jan 5, 1978 under 4581 - 174; prepared by Cannon 05 -Jan 1978 Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580- Y) St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of 84475 Hydrothol 191 Liquid (N.B. 77- 100 - 2) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits: Laboratory No. 7E - 5664. (Unpublishe d study received Jan 5, 1978 under 4581 - 174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt 05 -Jan 1978 Corp., Philadelphia, Pa.; CDL:232580 -Z) 84604 Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012- J through 246012 - P. (Unpublished study received Sep 14, 1981 under 4581 - 349; CDL:246012 - B) 14 - Sep 1981 Inglis, A.; Davis, E.L. (1972) Effects of Water Hardness on the Toxicity of Several 85213 Organic and Inorganic Herbicides to Fish. By U.S. Fish and Wildlife Ser vice, Fish Pesticide Research Laboratory. Washington, D.C.: USFWS. (Technical papers of the 08 - Dec 1977 Bureau of Sport Fisheries and Wildlife 67; published study; CDL: 232666- L) 96292 Eibert, J., Jr. (1967) Acute Dermal Toxicity (LDI50) in Rabbits: S.A.No. 127387. (Unpublished study received Feb 17, 1967 under 7F0570; prepared by Scientific Associates, Inc., submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719- C) 17 - Feb 1967 20 - Dec 1983 96293 Eibert, J., Jr. (1967) Dermal Irritation in Rabbi ts: S.A. No. 127388. (Unpublished study received Feb 17, 1967 under 7F0570; prepared by Scientific Associates, Inc., submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719 - D) 17 - Feb 1967 20 - Dec 1983 96295 Walker, C.R. (1963) Letter sent to Harold L. Lindaberry dated Nov 8, 1963 Fish toxicity studies. (U.S. Fish and Wildlife Serv -ice, Fish Control Laboratory; unpublished study; 23 - Mar1967 

### 139CDL:090719 - G) 96296 Cope, O.B. (1966) Letter sent to Edward J. Bowles dated Sep 1, 1966 Fish toxicity of De s - i- cate (Accelerate). (U.S. Fish and Wildlife Service, Fish - Pesticide Research Laboratory; unpublished study; CDL:090719 - H) 23 - Mar1967 96297 Pennsalt Chemicals Corporation (1967) Toxicity to Fish: Accelerate, Accelerate + Folex, and Accelerate + Sodium Chlorate. (Unpublished study received Feb 17, 1967 under 7F0570; CDL:090719 - I) 17 - Feb 1967 96301 Pennsalt Chemicals Corporation (1967) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method Used: Accele rate. (Compilation; unpublished study received Feb 17, 1967 under 7F0570; CDL:090719- N) 17 - Feb 1967 96303 Pennsalt Chemicals Corporation (1967) Efficacy of Accelerate to Cotton. (Compilation; unpublished study received Feb 17, 1967 under 7F0570; CDL:0907 19 - S) 17 - Feb 1967 101732 Pennwalt Corp. (1963) Chemical Studies of Endothall Technical, Accelerate and Des - icate. (Compilation; unpublished study received Oct 30, 1963 under 4581 - 284; CDL:007455 - A) 30 - Oct 1963 Pennwalt Corp. (1966) Efficacy of Accelerate, Des - i- cate and Other Compounds for 101733 Defoliation of Cotton. (Compilation; unpublished study received on unknown date under 4581 - 284; CDL:007455 - B) 101734 Pennwalt Corp. (1954) Full Reports of Investigations Made with Respect to the Safety of the Product: Disodium Endothall. (Un -published study received Oct 30, 1963 under 4581 - 284; CDL: 007455- C) 30 - Oct 1963 Eibert, J. (1966) Summary of Safety Evaluation and Other Animal Studies on Disodium 101735 Endothall. (Unpublished study received on un known date under 4581 - 284; prepared by Scientific Associates, Inc., submitted by Pennwalt Corp., Philadelphia, PA; CDL: 007455 ­ D) Inglis, A.; Davis, E. (1968) The Effect of Water Hardness on the Toxicity to Fish of 102626 Several Organic and Inorganic Herbicides. (Unpublished paper presented at the 8th meeting of the Weed Society of America, Feb 5 - 8, 1968, New Orleans, LA; unpublished study received Jul 18, 1972 under 2E1221; submitted by U.S. Dept. of the Army, 18 -Jul 197 2 Washington, DC; CDL:091051 - R) 113927 Agchem (1966) Description of Analytical Methods and Results of Analyses for Dimethylcocoamine Endothall (Accelerate) in Cottonseed. (Compilation; unpublished study received Feb 14, 1966 under 4581 - 284; CDL:007456 - A) 14 - Feb 1966 113931 Agchem (1 970) A Special Study on Residues of Endothall on Lint and Seed from Cotton Treated with Accelerate. (Unpublished study received Dec 15, 1970 under 0F0972; CDL:091670 - D) 15 - Dec 1970 113936 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of E ndothall. (Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094507- A) 01 - Dec 1970 28 - Apr113953 Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method Used: Endothall. (Compilation; unpublished study received May 13, 1972 under 1F1105; CDL:094506- H) 1972 04 - May 1972 13 - May 1972 113954 Pennwalt Corp. (1971) A Report of Two Studies on Residues in Potatoes and Soil after Treatment with Endothall and 14C Endothall Formulated as DES -I- CATE. (Compilation; 

### 140unpublished study received on unknown date under 1F1057; CDL:093370 - A) 29 - Nov Latven, A. (1971) Accelerate: Summary -- Acute Dermal Toxicity in Rabbits: Nontoxic at 1971 113955 250 MG/KG. (Unpublished study received Nov 29, 19 71 under 1F1057; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:093370- 09 -Jul 1975 C) 20 - Dec 1983 Latven, A. (1971) Accelerate: Summary -- Eye Irritancy in Rabbits: Corneal Opacification, 113956 Iridal Con gestion, Conjunctival Inflammation and Chemosis. (Unpublished study received Nov 29, 1971 under 1F1057; prepared by Pharmacology Research, Inc., submitted by 29 - Nov 1971 Pennwalt Corp., Tacoma, WA; CDL:093370 - D) 113957 Pennwalt Corp. (1971) Name, Chemica l Identity and Composition of Pesticide Chemical: Endothall. (Compilation; unpublished study received Jan 20, 1971 under 1F1057; CDL:093370 - E) 20 -Jan 1971 113958 Pennwalt Corp. (1971) The Amount, Frequency, and Time of Application of the Pesticide Chemic al: Endothall. (Compilation; un -published study received Jan 20, 1971 under 1F1057; CDL: 093370 - F) 20 -Jan 1971 113966 Pennwalt Corp. (1974) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method Used: E ndothall. (Compilation; unpublished study received May 1, 1974 under 4G1510; CDL:094009- A) 01 - May 1974 113967 Pennwalt Corp. (1975) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Methods Used: Endothall . (Compilation; unpublished study received Feb 1, 1975 under 3F1416; CDL:093784- A) 01 - Feb 1975 113968 Pennwalt Corp. (1974) The Name, Chemical Identity, and Composition of the Pesticide Chemical: Endothall. (Compilation; unpublished study received May 1, 1974 under 4G1510; CDL:094010 - A) 01 - May 1974 113969 Pennwalt Corp. (1974) The Amount, Frequency, and Time of Application of the Pesticide Chemical: Endothall. (Compilation; unpublished study received May 1, 1974 under 4G1510; CDL: 094010 - B) 01 - May 1974 113971 Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of the Product: Endothall. (Compilation; unpublished study received on unknown date under 1F1105; CDL:094509 - A) 03 - May 1971 Latven, A. (1971) Accelerate: Summary -- Acute Oral Toxicity in Starved Rats: LD50 = 113972 650 MG/KG (0.57 ML/KG). (Unpublished study received Nov 29, 1971 under 4581 - 284; prepared by Pharmacology Research, Inc., submitted by Agchem Div., Pennwalt Corp., 29 - No v 1971 Philadelphia, PA; CDL:100915 - A) Walker, C. (1961) The Toxicology, Residue, Degradation, and Effectiveness of Disodium 08 -Jul 113983 Endothal and the Dimethyleocoamine Derivative as Aquatic Herbicides in Fisheries Habitat. (Unpublished study received Jul 8, 1965 under 4581 - 232; submittedby Agchem 1965 15 - MarDiv., Pennwalt Corp., Philadelphia, PA; CDL:121844- S) 1966 113987 Agchem (1970) The Results of Tests on the Amount of Residue Remaining Including a Description of the Analytical Method Used: Endothall. (Compilation; unpublis hed study received Jun 27, 1971 under unknown admin. no.; CDL:124882 - A) 27 -Jun 1971 114487 Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and Complete Composition of the Product: Endothall. (Compilation; unpublished stud y received Jul 9, 1975 under 1F1105; CDL:094700 - A) 09 -Jul 1975 

### 141114488 Pennwalt Corp. (1975) Full Reports and Data of Investigations Made on the Safety of the Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094702- A) 09 -Jul 1975 Latven, A. (1971) Accelerate: Summary -- Acute Oral Toxicity in Starved Rats: LD50 = 114491 650 Mg/Kg (0.57 Ml/Kg). (Unpublished study received Jul 9, 1975 under 1F1105; prepared by Pharmacology Research, Inc ., submitted by Pennwalt Corp., Tacoma, WA; 09 -Jul 1975 CDL: 094702- D) 114492 Pennwalt Corp. (1972) Responses of Plankton and Macrofauna Communities To Test Application of Chemical Herbicides. (Unpublished study received Jul 9, 1975 under 1F1105; CDL:094 702 - H) 09 -Jul 1975 114499 Pennwalt Corp. (1962) Chemical and Physical Properties: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094706 - A) 09 -Jul 1975 114500 Pennwalt Corp. (1975) Toxicity: Endothall. (Compilation; unpublished study received Jul 9, 1975 under 1F1105; CDL:094706 - B) 09 -Jul 1975 114501 Pennwalt Corp. (1974) Residues: Endothall. (Unpublished study received Jul 9, 1975 under 1F1105; CDL:094706- C) 09 -Jul 1975 114504 Pennwalt Corp. (1975) Duration of Biol ogical Activity: Endothall. (Unpublished study received Jul 9, 1975 under 1F1105; CDL: 094706- F) 09 -Jul 1975 114511 Cope, O. (1965) Letter sent to E. Bowles dated Jul 23, 1965 Toxicity study of several Pennwalt herbicides against rainbow trout. (U.S. Fis h and Wildlife Service, Fish - Pesticide Research Laboratory; unpublished study; CDL:007441 - K) 15 - Mar1966 114513 U.S. Fish and Wildlife Service, Fish Control Laboratory (19) Toxicity Study of Selected Test Chemicals on Rainbow Trout, Goldfish, Black Bullh ead, and Bluegill. (Unpublished study; CDL:007441 - M) 15 - Mar1966 114514 Walker, C. (1963) Letter sent to H. Lindaberry dated Apr 24, 1963 Toxicity study of selected pesticides on test animals. (U.S. Fish and Wildlife Service, Fish Control Laboratory; unp ublished study; CDL:007441 - N) 15 - Mar1966 Howell, J. (1963) Letter sent to H. Lindaberry dated Jan 23, 1963 Toxicity of specific 114515 Pennsalt chemicals to the sea lamprey and rainbow trout. (U.S. Fish and Wildlife Service, Bureau of Commercial Fisheri es, Hammond Bay Biological Station; unpublished study; 15 - Mar1966 CDL:007441 - O) 114516 Zarbock, W. (1961) Letter sent to H. Lindaberry dated Oct 25, 1961 Toxicity test results for TD 191 on bluegills. (Ohio, Dept. of Natural Resources, Div. of Wildlife; unpublished study; CDL: 007441 - P) 15 - Mar1966 114517 Bowles, E.; Keckemet, J.; Boyle, W.; et al. (1965) Hydrothol 191 as an Aquatic Herbicide in Flowing Water. (Unpublished study re -ceived Mar 15, 1966 under 4581 - 139; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:007441 - Q) 15 - Mar1966 114529 Agchem (1975) Chemistry Data on Endothall. (Compilation; unpublished study received Feb 1, 1975 under 4581 - EX - 21; CDL: 094726- A) 01 - Feb 1975 114530 Agchem (1972) Efficacy of Endothall on Variou s Crops. (Compilation; unpublished study received May 4, 1972 under 4581 - 284; CDL:095336- B) 04 - May 1972 114535 Pennwalt Corp. (1973) The Name, Chemical Identity, and Composition of the Pesticide Chemical: Endothall. (Compilation; unpublished study receiv ed Jun 27, 1973 under 3F1416; CDL:095419 - B) 27 -Jun 1973 114536 Keckemet, O. (1973) The Amount, Frequency, and Time of Application of the Pesticide 27 -Jun 

### 142Chemical: Endothall. (Unpublished study received Jun 27, 1973 under 3F1416; submitted 1973 by Pennwalt Corp., Ta coma, WA; CDL:095419- C) 114539 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Accelerate Cotton Harvest Aid. (Compilation; unpublished study received Apr 15, 1970 under 0F0972; CDL:095421 - B) 15 - Apr1970 114540 Watson, J. ( 1970) Full Reports of Investigations Made with Respect to the Safety of the Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15, 1970 under 0F0972; submitted by Pennwalt Corp., Tacoma, WA; CDL:095421 - F) 15 - Apr1970 11455 7 Agchem (1977) Residues of Endothal in Soil. (Compilation; un -published study received Oct 26, 1978 under 4581 - 282; CDL: 235432 - C) 26 - Oct 1978 114558 Agchem (1975) Residues of Endothall in Water. (Compilation; unpublished study received Oct 26, 1978 un der 4581 - 282; CDL: 235432 - D) 26 - Oct 1978 Inglis, A.; Davis, E. (1972) Effects of Water Hardness on the Toxicity of Several Organic 115756 and Inorganic Herbicides to Fish. By U.S. Fish and Wildlife Service, Fish - Pesticide Research Laboratory. Washington, DC: USFWS. (Technical papers of the Bureau of Sport 21 - Oct 1982 Fisheries and Wildlife 67; published study; CDL: 248614 - P) 115984 Pennsalt Chemicals Corp. (1967) Efficacy of Endothall and Other Chemicals on Potatoes. (Compilation; unpublished study rece ived Jun 16, 1967 under 7G0608; CDL:090782 - C) 16 -Jun 1967 116025 Pennwalt (1970) Endothal: Residues in Various Crops. (Compilation; unpublished study received on unknown date under 1F1105; CDL:090872- A) 3M Co. (1970) Residue Analyses of 3MCAP - D and Other Chemicals in Various Products. 116737 (Compilation; unpublished study received on unknown date under 10556- EX - 1; CDL:127733 - A) 124667 Agchem (1967) The Amount, Frequency, and Time of Application of the Pesticide Chemical: Accelerate Cotton Harvest Aid. (Compilation; unpublished study received Feb 15, 1967 under 6G0503; CDL:094600 - A) 15 - Feb 1967 128664 Agchem (1975) Additional Data in Support of a Petition for Estab -lishment of a Temporary Negligible Tolerance for Endothall in or on Rice. (Compil ation; unpublished study received Jun 1, 1983 under 45811 - 74; CDL:250413 - A) 01 -Jun 1983 Becker, J.; Parke, G. (1977) The Acute Dermal LD50 of Des -I- Cate/ Accelerate (N.B. 77­ 133023 99 - 6) on New Zealand Albino Rabbits: Laboratory No. 7E - 5677. (Unpublishedstudy received Dec 20, 1983 under 4581 - 206; prepared by Cannon Laboratories, Inc., submitted 20 - Dec 1983 by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:252010 - D) Pierre, F.; Parke, G. (1977) A Primary Dermal Irritation Study of Des -I- Cate/Accelerate 133024 (N.B. 77 - 99 - 6) on Abraded and Non - abraded Skin of New Zealand Albino Rabbits: Laboratory No. 7E - 5679. (Unpublished study received Dec 20, 1983 under 4581 - 206; pre pared by Cannon Laboratories, Inc., submitted by Agchem Div., Pennwalt Corp., 20 - Dec 1983 Phi ladelphia, PA; CDL:252010 - E) 134936 Agchem (1966) Residues: Accelerate. (Compilation; unpublished study received 1966 under 6G0503; CDL:092789 - A) 01 -Jan 1966 147209 Interregional Research Project No. 4 (1985) The Results of Tests on the Amo unt of Endothall Residues Remaining in or on Hops Including a Description of the Analytical Method Used. Unpublished compilation. 30 p. 30 - Apr1985 147227 Interregional Research Project No. 4 (1984) Endothall on Hops: Efficacy and Phytotoxicity Data: PR No. 2381. Unpublished com - pilation. 9 p. 30 - Apr1985 

### 143152170 Deenihan, M. (1984) Primary Eye Irritation of Hydrothol 191 NVP Report No. X4K065­ G. Unpublished study prepared by Northview Pacific Laboratories, Inc. 9 p. 07 - Feb 1985 42359700 Atochem NorthAmerica (1992) Submission of Data in Support of Endothall Acid (Technical) as Required in the Reregistration DCI: Toxicology Studies. Transmittal of 2 studies. 17 -Jun 1992 42359701 Pedersen, C.; Helsten, B. (1992) Endothall Technical: 21 - Day Acute Oral LD50 Study in Mallard Ducks: Lab Project Number: 106- 004 - 04. Unpublished study prepared by Bio Life Associates, Ltd. 50 p. 17 -Jun 1992 42560900 Atochem North America, Inc. (1992) Submission of toxicity data in support of the data call - in for Endothall (H ydrothol 191). Transmittal of 1 study. 19 - Nov 1992 42560901 Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Hydrothol 191 in the Rat: Final Report: Lab Project Number: 91 - 8356. Unpublished study prepared by Bio/dynamics, Inc. 126 p. 19 - Nov 1992 42629800 Elf Atochem N.A., Inc. (1993) Submission of product chemistry data in support of the data call - in for Endothall, Amine Salt. Transmittal of 1 study. 21 -Jan 1993 42629801 Sweetapple, G. (1992) Amine Salt of Endothall Acid -- Color, Physical State , Odor, Density, pH: Lab Project Number: 4200 - 92- 0334- AS: 4200 - 92- 0334 - AS - 001. Unpublished study prepared by Ricerca, Inc. 43 p. 21 -Jan 1993 42670200 Elf Atochem N.A., Inc. (1993) Submission of environmental fate data in support of the Endothall (Amine Salt) data call- in. Transmittal of 1 study. 18 - Feb 1993 Wright, J. (1993) Terrestrial Field Dissipation Studies for Endothall (DES -I- CATE a 42670201 Potato Vine Killer and a Harvest Aid for Alfalfa and Clover) Applied to Potatoes: Lab Project Number: WT - 1 - 85: BR - 92 - 54. Unpublished study prepared by Pennwalt Corp. 18 - Feb 1993 230 p. 42694500 Elf Atochem North America, Inc. (1993) Submission of Prior Efficacy Testing Data in Support of Experimental Use Permit for TD- 2335 (Hydrothol 191). Transmittal of 1 S tudy. 17 - Feb 1993 Krieg, D. et al. (1993) Compilation of Prior Efficacy Testing in Support of the 42694501 Experimental Use Permit Application for TD - 2335: Lab Project No. 2335. Unpublished study prepared by Roger Boren, Inc., S - L Agri- Development Corp. and D. Krieg Farm. 64 17 - Feb 1993 p. 42774000 Elf Atochem North America Inc. (1993) Submission of toxicity data in support of the reregistration DCI for Endothall, Amine Salt. Transmittal of 3 studies. 14 - May 1993 42774001 Mallory, V. (1993) Acute Expo sure Oral Toxicity in Rats with Hydrothol 191 (Endothall): Lab Project Number: PH 402 - ANA - 002 - 92. Unpublished study prepared by Pharmakon Research International, Inc. 169 p. 14 - May 1993 42774002 Mallory, V. (1993) Acute Exposure Dermal Toxicity with Hydr othol 191 (Endothall): Lab Project Number: PH 422 - ANA - 005 - 92. Unpublished study prepared by Pharmakon Research International, Inc. 78 p. 14 - May 1993 42774003 Mallory, V. (1993) Primary Dermal Irritation study with Hydrothol 191 (Endothall): Lab Project N umber: PH 420 - ANA - 002 - 92. Unpublished study prepared by Pharmakon Research International, Inc. 34 p. 14 - May 1993 42783200 Elf Atochem NA, Inc. (1993) Submission of product chemistry data to support the reregistration standard for Endothall. Transmittal o f 1 study. 24 - May 1993 42783201 Wojcieck, B. (1993) Hydrothol 191 (Granular): Color, Physical State, Odor, Bulk 24 - May 

### 144Density, pH: Lab Project Number: 4200 - 92- 0182- AS. Unpublished study prepared by 1993 Ricerca, Inc. 22 p. 42889100 Elf Atochem North A merica, Inc. (1993) Submission of product chemistry data in support of reregistration for endothall. Transmittal of 1 study. 19 - Aug 1993 42889101 Wojcieck, B. (1993) Accelerate -- Color, Physical State, Odor, Specific Gravity, pH, Viscosity: Lab Project Nu mber: 4200 - 92- 0174- AS. Unpublished study prepared by Ricerca, Inc. 46 p. 19 - Aug 1993 43081300 Elf Atochem North America, Inc. (1993) Submittal of Product Chemistry Data in Response to DCI for Reregistration of Endothall Amine Salt. Transmittal of 1 study . 11 -Jan 1994 43081301 Gallacher, A. (1993) Amine Salt of Endothall Acid -- Dissociation Constant: Lab Project Number: 4200 - 92 - 0323 - AS. Unpublished study prepared by Ricerca, Inc. 63 p. 11 -Jan 1994 43082000 Elf Atochem North America, Inc. (1993) Submitta l of Corrosion Characteristics Data in Support of Reregistration of Endothall Amine Salt (Hydrothol 191 Aqueous, Hydrothol 191 Granular, and Accelerate). Transmittal of 3 studies. 11 -Jan 1994 43082001 Sweetapple, G. (1993) Hydrothol 191, Aqueous -- Corrosi on Characteristics: Lab Project Number: 4200 - 92 - 0181 - AS. Unpublished study prepared by Ricerca, Inc. 39 p. 11 -Jan 1994 43082002 Sweetapple, G. (1993) Hydrothol 191, Granular -- Corrosion Characteristics: Lab Project Number: 4200 - 92 - 0183 - AS. Unpublished stu dy prepared by Ricerca, Inc. 35 p. 11 -Jan 1994 43082003 Sweetapple, G. (1993) Accelerate -- Corrosion Characteristics: Lab Project Number: 4200 - 92 - 0175 - AS. Unpublished study prepared by Ricerca, Inc. 35 p. 11 -Jan 1994 43154800 Elf Atochem North America, Inc. (1993) Submission of toxicity data in support of reregistration for Endothall Amine Salts. Transmittal of 1 study. 11 -Jan 1994 43154801 Stankowski, L. (1993) Ames/Salmonella Plate Incorporation Assay on Technical Endothal Amine Salt Solution: Lab Pr oject Number: PH/301/ANA/001/92. Unpublished study prepared by Pharmakon Research International, Inc. 110 p. 11 -Jan 1994 43157400 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothal Amine Salt in Support of DCI Reregistration.Transmittal of 1 Study. 15 - Mar1994 SanSebastian, J. (1994) In Vivo Micronucleus Test on Technical Endothal Amine Salt 43157401 Solution in Mouse Bone Marrow Erythropoietic Cells: Lab Project Number: PH 309- ANA - 001 - 92. Unpublished study prepared by Phar makon Research International, Inc. 73 15 - Mar1994 p. 43167900 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Hydrothol 191 Aquatic Algicide and Herbicide in Support of Reregistration Data Call - In. Transmittal of 2 studies. 22 - Mar1994 43167901 Pedersen, C.; Thompson, S. (1994) Hydrothol 191 Aquatic Algicide and Herbicide: 8 - Day Acute Dietary LC50 Study in Bobwhite Quail: Lab Project Number: 106 - 012- 01: HWA 153 - 148. Unpublished study prepared by Bio - Life Associates, Ltd. 100 p. 22 - Mar1994 43167902 Pedersen, C.; Thompson, S. (1994) Hydrothol 191 Aquatic Algicide and Herbicide: 8 - Day Acute Dietary LC50 Study in Mallard Ducklings: Lab Project Number: 106- 016 - 02: HWA 153 - 148. Unpublished study prepared by Bio - Life Associates, Ltd. 96 p. 22 - Mar1994 43169200 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothall, Amine Salt (Hydrothol 191) in Support of a Data Call - In Reregistration. Transmittal of 1 study. 23 - Mar1994 43169201 Armondi, S. (1993) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with 23 - Mar

### 145Hydrothol 191: Lab Project Number: PH 424- ANA - 003 - 92: ALC- 28C2 - 03. Unpublished 1994 study prepared by Pharmakon Research International, Inc. 106 p. 43196900 Elf Atochem North America, Inc. (19 94) Submittal of Acute Aquatic Toxicity Data in Support of Reregistration of Endothall, Amine Salt. Transmittal of 3 studies. 18 - Apr1994 43196901 Bettencourt, M. (1994) Hydrothol 191 -- Acute Toxicity to Rainbow Trout (Oncorhynchus mykiss) Under Flow - Thro ugh Conditions: Final Report: Lab Project Number: 93 - 8 - 4891: 12442.0591.6138.108. Unpublished study prepared by Springborn Laboratories, Inc. 75 p. 18 - Apr1994 43196902 Putt, A. (1994) Hydrothol 191 -- Acute Toxicity to Daphnids (Daphnia magna) Under Flow - Through Conditions: Final Report: Lab Project Number: 93 - 9 - 4932: 12442.0591.6139.115. Unpublished study prepared by Springborn Laboratories, Inc. 87 p. 18 - Apr1994 Bettencourt, M. (1994) Hydrothol 191 -- Acute Toxicity to Sheepshead Minnow 43196903 (Cyprin odon variegatus) Under Flow - Through Conditions: Final Report: Lab Project Number: 93 - 10- 4980: 12442.0591.6140.505. Unpublished study prepared by Springborn 18 - Apr1994 Laboratories, Inc. 70 p. 43210000 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothall Amine Salt in Support of Reregistration Data Call - In. Transmittal of 1 study. 02 - May 1994 43210001 Putt, A. (1994) Hydrothol 191 -- Acute Toxicity to Mysid Shrimp (Mysidopsis bahia) Under Flow - Through Conditions: Final Report: Lab Project Number: 93 - 10- 5000: 12442.0591.6141.515. Unpublished study prepared by Springborn Labs., Inc. 72 p. 02 - May 1994 43242300 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for ACCELERATE Harvest Aid for Cotton in Support of Re registration DCI. Transmittal of 3 studies. 24 - May 1994 43242301 Mallory, V. (1994) Acute Exposure Oral Toxicity with Accelerate: Lab Project Number: PH 402 - ANA - 003 - 93. Unpublished study prepared by Pharmakon Research International, Inc. 170 p. 24 - May 1994 43242302 Mallory, V. (1994) Acute Exposure Dermal Toxicity with Accelerate: Lab Project Number: PH 422 - ANA - 005 - 93. Unpublished study prepared by Pharmakon Research International, Inc. 93 p. 24 - May 1994 43242303 Mallory, V. (1994) Primary Dermal Irri tation Study with Accelerate: Lab Project Number: PH 420 - ANA - 003 - 93: DAF - 27H3 - 04. Unpublished study prepared by Pharmakon Research International, Inc. 39 p. 24 - May 1994 43265100 Elf Atochem North America, Inc. (1994) Submittal of Product Chemistry in Sup port of Reregistration of ENDOTHALL. Transmittal of 1 study. 10 -Jun 1994 43265101 Malone, S. (1994) Amine Salt of Endothall TG (B46- 48)-- Stability: Lab Project Number: 4200- 92 - 0353 - AS - 001: 4200 - 92- 0353 - AS. Unpublished study prepared by Ricerca, Inc. 57 p . 10 -Jun 1994 43276500 Elf Atochem North America, Inc. (1994) Submission of toxicology data in support of reregistration of Endothall Amine Salt. Transmittal of 1 study. 21 -Jun 1994 Bettencourt, M. (1994) Hydrothol 191: The Toxicity to FatheadMinnow (Pimephales 43276501 promelas) During an Early Life - Stage Exposure: Final Report: Lab Project Number: 94/1/5121: 12442/0692/6151/120. Unpublished study prepared by Springborn 21 -Jun 1994 Laboratories, Inc. 84 p. 43299900 Elf Atochem North America, Inc. (1 994) Submission of exposure assessment data in support of DCI for reregistration of endothall. Transmittal of 1 study. 12 -Jul 1994 43299901 Lunchick, C. (1994) Assessment of Worker Exposure and Margins of Exposure for 12 -Jul 

### 146Endothall Potassium and Amine Salt F ormulation: Lab Project Number: EA070594. 1994 Unpublished study prepared by Jellinek, Schwartz & Connolly, Inc. 82 p. 43319600 Elf Atochem North America, Inc. (1994) Submission of product chemistry data in support of reregistration for Amine Salt of Endothall. Transmittal of 1 study. 29 -Jul 1994 43319601 Lorence, P. (1994) Amine Salt of Endothall: Vapor Pressure: Lab Project Number: 4200/92/0261/AS: 4200/92/0261/AS/001. Unpublished study prepared by Ricerca, Inc. 70 29 -Jul 1994 p. 43343500 ElfAtochem North America, Inc. (1994) Submission of toxicity data in support of reregistration for Endothall. Transmittal of 3 studies. 22 - Aug 1994 43343501 Mallory, V. (1994) Comparative Acute Exposure Dermal Toxicity of Accelerate: Lab Project Number: PH /422/ANA/001/94. Unpublished study prepared by Pharmakon Research International, Inc. 229 p. 22 - Aug 1994 43343502 Mallory, V. (1994) Comparative Primary Dermal Irritation Study of Accelerate: Lab Project Number: PH/420/ANA/001/94. Unpublished study prepared by Pharmakon Research International, Inc. 39 p. 22 - Aug 1994 43343503 Margitich, D. (1994) 7 Day Repeat Dermal Toxicity Study in Rats Dose - Range - Finding: Amine Salt of Endothall: Lab Project Number: PH/442/ANA/001/93. Unpublished study prepared by Pharmakon Research International, Inc. 124 p. 22 - Aug 1994 43346600 Elf Atochem North America, Inc. (1994) Submission of Residue Data in Support of Endothall Reregistration. Transmittal of 1 Study. 23 - Aug 1994 43346601 Sanger, T. (1994) Mono - (N,N- Dimethyla lkylamine) Salt of (carbon 14) - Endothall: Nature of the Residue in Cotton: Final Report: Lab Project Number: HWI 6120 - 168: BR - 93 - 48: R149301. Unpublished study prepared by Hazleton Wisconsin, Inc. 118 p. 23 - Aug 1994 43437800 Elf Atochem North America, In c. (1994) Submittal of Gene Mutation Data in Support of Reregistration of ENDOTHALL, Amine Salt. Transmittal of 1 study. 11 -Jan 1994 43437801 Stankowski, L. (1993) AS52/XPRT Mammalian Cell Forward Gene Mutation Assay on Technical Endothal Amine Salt Solu tion: Lab Project Number: PH 314- ANA - 001 - 92. Unpublished study prepared by Pharmakon Research International, Inc. 144 p. 11 -Jan 1994 43437900 Elf Atochem North America, Inc. (1994) Submission of Toxicity to Aquatic Organisms Data in Support of the Reregistration of the Amine Salt of Endothall. Transmittal of 1 Study. 07 -Jun 1994 43437901 Putt, A. (1994) Hydrothol 191 -- The Chronic Toxicity to Daphnia magna Under FlowThrough Conditions: Final Report: Lab Project Number: 93 - 11 - 5014: 12442.0692.6150.130. U npublished study prepared by Springborn Labs, Inc. 117 p. 07 -Jun 1994 43441500 Elf Atochem North America, Inc. (1994) Submission of Product Chemistry Data in Support of the Reregistration of Endothall and Salts Group. Transmittal of 2 Studies. 04 - Nov 19 94 43441501 Lorence, P. (1994) Amine Salt of Endothall -- Octanol/Water Partition Coefficient: Lab Project Number: 4200 - 92 - 0260 - AS: 4200- 92 - 0260- AS - 001. Unpublished study prepared by Ricerca, Inc. 53 p. 04 - Nov 1994 43441600 Wacker Silicones Corp. (1994) Submission of Product Chemistry and Toxicology Data in Support of Petition for (Inert Ingredient). Transmittal of 4 Studies. 02 - Sep 1994 43441601 Etter, S. (1994) (Inert Ingredient): Density Determination. Unpublished study prepared by Wacker - Chemie GmbH. 4 p. 02 - Sep 1994 43441602 Etter, S. (1994) (Inert Ingredient): Volatility. Unpublished study prepared by Wacker - 02 - Sep 

### 147Chemie GmbH. 11 p. 1994 43441603 Etter, S. (1994) (Inert Ingredient): Refractive Index and Residual HCl. Unpublished study prepared by Wacker - Chemie GmbH. 7 p. 02 - Sep 1994 43441604 Plotzke, K.; McMahon, J. (1993) Feasibility Study: In vitro Percutaneous Absorption of (carbon 14)- (Inert Ingredient) Fluid 350 cst in Male Rat Skin: Lab Project Number: 1993 - 10000 - 38673. Unpublished study prepared by Dow Corning Corp. 13 p. 02 - Sep 1994 43465200 Elf Atochem North America, Inc. (1994) Submission of Toxicology Data in Support of Endothall Reregistration. Transmittal of 1 Study. 22 - Aug 1994 43465201 Margitich, D.; Ackerman, L. (1994) 21 Da y Dermal Toxicity Study in Rats: Amine Salt of Endothall: Lab Project Number: PH 430 - ANA - 001 - 93. Unpublished study prepared by Pharmakon Research International, Inc. 323 p. 22 - Aug 1994 43470100 Elf Atochem North America, Inc. (1994) Submission of Exposur e Data in Support of Endothall Reregistration. Transmittal of 1 Study. 02 - Dec 1994 43470101 Lunchick, C. (1994) Assessment of Swimmer Exposure to Endothall in Aquathol -and Hydrothol-Treated Bodies of Water. Unpublished study prepared by Jellinek, Schwa rtz, and Connolly, Inc. 11 p. 02 - Dec 1994 43472800 Elf Atochem North America, Inc. (1994) Submission of Toxicity and Product Chemistry Data in Support of the Reregistration of Endothall, Amine Salt. Transmittal of 3 Studies. 06 - Dec 1994 43472801 Betten court, M. (1994) Hydrothol 191 -- Acute Toxicity to Bluegill Sunfish (Lepomis macrochirus) Under Flow- Through Conditions: Final Report: Lab Project Numbers: 94- 4- 5253: 12442.0394.6169.105. Unpublished study prepared by Springborn Labs, Inc. 74 p. 06 - Dec 199 4 43472802 Lorence, P. (1994) Amine Salt of Endothall -- Solubility: Lab Project Numbers: 4200 - 92- 0259- AS: 4200- 92- 0259- AS - 001. Unpublished study prepared by Ricerca, Inc. 68 p. 06 - Dec 1994 43480800 Elf Atochem North America, Inc. (1994) Submission of Tox icity Data in Support of Reregistration of Endothall, Amine Salt. Transmittal of 2 Studies. 13 - Dec 1994 43480801 Trutter, J. (1994) 13 -Week Subchronic Toxicity Study in Rats with Amine Salt of Endothall: Final Report: Lab Project Number: HWA 153 - 152. Unp ublished study prepared by Hazleton Washington, Inc. 520 p. 13 - Dec 1994 43480802 Trutter, J. (1994) 13 -Week Subchronic Toxicity Study in Dogs with Amine Salt of Endothall: Final Report: Lab Project Number: HWA 153 - 153. Unpublished study prepared by Hazle ton Washington, Inc. 376 p. 13 - Dec 1994 43550200 Elf Atochem North America, Inc. (1995) Submission of Hazard to Aquatic Organisms Data in Support of Endothall Reregistration. Transmittal of 1 Study. 15 - Feb 1995 Dionne, E. (1995) Hydrothol 191 -- Acute Neurotoxicity to Eastern Oyster (Crassostrea 43550201 virginica) Under Flow - through Conditions: Final Report: Lab Project Number: 12442.0591.6142.504: 93 - 8 - 4896. Unpublished study prepared by Springborn Labs, Inc. 15 - Feb 1995 108 p. 43870400 Elf Atochem No rth America, Inc. (1995) Submission of Hazard to Non - Target Plants Data in Support of the Reregistration of Endothall and Salts. Transmittal of 1 Study. 11 - Dec 1995 Hoberg, J. (1995) Hydrothol 191 -- Determination of Effects on Seedling Emergence and 43870401 Vegetative Vigor of Ten Plant Species: Final Report: Lab Project Number: 12442.0195.6185.610: BR - 94 - 20: 95 - 8 - 6045. Unpublished study prepared by Springborn 11 - Dec 1995 Labs, Inc. 339 p. 43873900 Elf Atochem North America, Inc. (1995) Submission of Pr oduct Chemistry Data in 13 - Dec 

### 148Support of the Amended Registrations of Aquathol K Aquatic Herbicide and Hydrothol 1995 191 Aquatic Algicide and Herbicide. Transmittal of 2 Studies. 43873902 Lincks, G. (1994) Hydrothol 1914 Aquatic Algicide and Herbicide Manufacturing Process: Lab Project Number: QC0007R0.QTR. Unpublished study prepared by Elf Atochem North America, Inc. 28 p. 13 - Dec 1995 43953100 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the Reregistration of Endoth all and Salts. Transmittal of 1 Study. 15 - Mar1996 43953101 Guyton, B. (1996) Endothall: Magnitude of the Residue in Potato: Lab Project Number: BR - 93 - 01: U:\ ATOCHEM \ BR9301FR.DOC. Unpublished study prepared by McKenzie Laboratories, Inc. 315 p. 15 - Mar1996 43954900 Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in Support of the Registration of Amended Registration of Hydrothol 191 Granular Aquatic Algicide and Herbicide. Transmittal of 1 Study. 18 - Mar1996 43954901 Lincks , G.; Parker, J.; Wright, J. (1994) Hydrothol 191 Granular Aquatic Algicide and Herbicide: Manufacturing Process: Lab Project Number: QC0012R0.QTR: QC0003R3.PAM. Unpublished study prepared by Elf Atochem North America, Inc. 23 p. 18 - Mar1996 43955000 ElfAtochem North America, Inc. (1996) Submission of Product Chemistry Data in Support of the Amended Registration of Accelerate: A Harvest Aid for Cotton. Transmittal of 1 Study. 18 - Mar1996 43955001 Lincks, G.; Parker, J.; Wright, J. (1994) Accelerate: A Harvest Aid for Cotton: Manufacturing Process: Lab Project Number: QC0009R0.QTR: QC0003R3.PAM. Unpublished study prepared by Elf Atochem North America, Inc. 28 p. 18 - Mar1996 44012100 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the Reregistration of Endothall and Salts. Transmittal of 1 Study. 15 - May 1996 Ussary, J. (1996) Endothall: Magnitude of the Residue in Potato Processed Fractions: 44012101 Final Report: Lab Project Number: BR - 90- 09: 52A - 90: 52B - 90. Unpublishedstudy prepared by Elf Atochem North America, Inc.; Ussary Scientific Services; and McKenzie 15 - May 1996 Labs, Inc. 303 p. 44037400 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the Reregistration of Endothall and Salts.Transmittal of 2 Studies. 18 -Jun 1996 Leppert, B. (1996) Endothall: Magnitude of the Residue in Cottonseed with Accelerate 44037402 and a Pre - Emergent Use of TD- 2335 - 2: Final Report: Lab Project Number: BR - 93 - 05: 05­ 93: 05A - 93. Unpublished study prepare d by Elf Atochem North America, Inc. 276 p. 18 -Jun 1996 {Relates to letter L0000075}. 44093400 Elf Atochem North America, Inc. (1996) Submission of Residue and Environmental Fate Data in Support of the Reregistration of Endothall and its Salts. Transmitt al of 3 Studies. 26 - Aug 1996 Ussary, J. (1996) Endothall: Magnitude of the Residue in Cottonseed Processed Fractions 44093401 from Application of Accelerate, The Harvest Aid for Cotton, and TD2335 - 2, a Proposed Boll Opener Use: Final Report: Lab Project Number: BR - 94 - 12: 94 - 12: 12A - 94. Unpublished study prepared by South Texas Ag Research High Plains, Inc.; Texas A&M 26 - Aug 1996 University; and McKenzie Labs. 232 p. 44103700 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of Reregistration of Endothall & Salts. Transmittal of 1 Study. 06 - Sep 1996 44103701 Carr, B. (1996) Residue of Endothall in Alfalfa Seed Following Application of Des - i- cate and Hydrothol 191 to Alfalfa Seed Crop: Lab Project Number: BR - 93 - 08: 08- 93: PRM 06 - Sep 1996 

### 1490 47. Unpublished study prepared by Elf Atochem North America, Inc. and McKenzie Laboratories. 219 p. 44127800 Elf Atochem North America, Inc. (1996) Submission of Toxicity Data in Support of the Reregistration of Endothall, Amine Salt. Transmi ttal of 6 Studies. 03 - Oct 1996 44127801 Hoberg, J. (1993) Hydrothol 191 -- Determination of Effects on Seed Germination of Ten Plant Species: Summary Report: Lab Project Number: 93 - 9 - 4942: 12442.0593.6159.610: 050892. Unpublished study prepared by Springbo rn Labs., Inc. 56 p. 03 - Oct 1996 44127802 Hoberg, J. (1994) Hydrothol 191 -- Toxicity to the Marine Diatom, Skeletonema costatum: Summary Report: Lab Project Number: 93 - 11 - 5025: 12442.0593.6162.450: 040692. Unpublished study prepared by Springborn Labs., I nc. 33 p. 03 - Oct 1996 44127803 Hoberg, J. (1994) Hydrothol 191 -- Toxicity to the Freshwater Alga, Anabaena flosaquae: Summary Report: Lab Project Number: 93 - 11 - 5023: 12442.0593.6163.420: 040692. Unpublished study prepared by Springborn Labs., Inc. 36 p. 03 - Oct 1996 Hoberg, J. (1994) Hydrothol 191 -- Toxicity to the Freshwater Alga, Selenastrum 44127804 capricornutum: Summary Report: Lab Project Number: 93 - 11 - 5022: 12442.0593.6160.430: 040692. Unpublished study prepared by Springborn Labs., Inc. 33 03 - Oct 1996 p. 44127805 Hoberg, J. (1994) Hydrothol 191 -- Toxicity to the Freshwater Diatom, Navicula pelliculosa: Summary Report: Lab Project Number: 93 - 11 - 5021: 12442.0593.6161.440: 040692. Unpublished study prepared by Springborn Labs., Inc. 33 p. 03 - Oct 1996 44127806 Hoberg, J. (1994) Hydrothol 191 -- Toxicity to Duckweed, Lemna gibba: Summary Report: Lab Project Number: 93 - 11 - 5024: 12442. 0593.6164.410: 040692. Unpublished study prepared by Springborn Labs., Inc. 32 p. 03 - Oct 1996 44263500 Elf Atochem NorthAmerica, Inc. (1997) Submission of Metabolism and Residue Data in Support of the Reregistration of Endothall and Salts. Transmittal of 8 Studies. 29 - Apr1997 Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44263506 Treatment of Celery with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR - 91 - 02: 70 - 91: 29 - Apr1997 70A - 91. Unpublished study prepared by McKenzie Labs, Inc. 237 p. Toth , J.; Antle, P. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44263507 Treatment of Grapefruit with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: (Final Report): Lab Project Number: BR - 91 - 04: 74- 91: 74A 29 - Apr1997 91. Unp ublished study prepared by McKenzie Labs, Inc. 224 p. Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44263508 Treatment of Peppers with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR - 91 - 05: 73 - 91: 29 - Apr1997 73A - 91. Unpublished study prepared by McKenzie Labs, Inc. 223 p. 44320400 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of Petition for Tol erance for Endothall on Apples. Transmittal of 3 Studies. 03 -Jul 1997 44320403 Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number: FQPA 697E. Unpublished study prepared by Elf Atochem N.A., Inc. 42 p. 03 -Jul 1997 44322 000 Elf Atochem North America, Inc. (1997) Submission of Residue, Toxicity and Exposure Data in Support of the Petition for Tolerance of Endothall on Cotton. Transmittal of 2 Studies. 01 -Jul 1997 44322001 Ussary, J. (1997) Endothall: Magnitude of the Res idue in Cottonseed and Gin By - 01 -Jul 

### 150Products After Application of Accelerate, the Harvest Aid for Cotton, and TD - 2335 - 02, a 1997 Proposed Boll Opener Product: Final Report: Lab Project Number: BR - 94 - 09: 09 - 94: 09G - 94. Unpublished study prepared by Ussary Scientific S ervices and McKenzie Labs. 415 p. 44322002 Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number: FQPA 697E. Unpublished study prepared by Elf Atochem North America, Inc. 42 p. 01 -Jul 1997 44334300 Elf Atochem N.A., Inc. (1997) Submission of Residue Data in Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 25 -Jul 1997 Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44334301 Treatment of Cabbage with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: Final Report: Lab Project Number: BR - 91 - 01: 71A - 91: 71B 91. Unpublished study prepared by Elf Atochem N.A., Inc. and McKenzie Labs, Inc. 241 25 -Jul 1997 p. 44 343100 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of the Reregistration for Endothall Acid & Salts. Transmittal of 1 Study. 06 - Aug 1997 Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 44343101 Treatment of Turnips with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or Hydrothol 191 Herbicides: Lab Project Number: BR - 91 - 06: 72A - 91: 72B - 91. 06 - Aug 1997 Unpublished study prepared by McKenzie Laboratories, Inc. 237 p. 44578400 Elf Atochem North America, Inc. (1998) Submission of Environmental Fate Data in Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 11 -Jun 1998 44578401 Mao, J. (1997) Endothall Amine Salt -- Determination of pH Dependent Hydrolysis: Lab Project Number: 12442.0396.6209.715: KP - 96 - 01: 96 - 6- 6537. Unpublished study prepared by Springborn laboratories, Inc. 79 p. 11 -Jun 1998 44608600 Elf Atochem North America, Inc. (1998) Submission of Residue Chemistry Data in Support of the Re registration of Endothall Acids and Salts. Transmittal of 1 Study. 16 -Jul 1998 44608601 Fomenko, J. (1998) Evaluation of Endothall Through the FDA Multiresidue Methods: Lab Project Number: A036.50: KP - 97 - 18. Unpublished study prepared by Maxim Technologi es, Inc. 63 p. {OPPTS 860.1360} 16 -Jul 1998 44700400 Elf Atochem North America, Inc. (1998) Submission of Toxicity Data in Support of the FIFRA 6(a)(2) Requirement for Hydrothol 191. Transmittal of 1 Study. 18 - Nov 1998 Serdar, D.; Johnson, A.; Stinson, M. (1995) Seawater Challenge of Chinook Salmon 44700401 Smolts (Onchorynchus tshawytscha) Exposed to the Aquatic Herbicide Hydrothol 191: Lab Project Number: 95 - 358. Unpublished study prepared by Washington State 18 - Nov 1998 Department of Ecology. 30 p. 44820100 Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, Risk Assessment and Exposure Data in Support of the Reregistration of Endothall Acid and Salts. Transmittal of 4 Studies. 05 - May 1999 Keckemet, O.; Sharp, J. (199 9) Historical Aquatic Residue and Dissipation Data for 44820101 Endothall Aquatic Products Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: Lab Project Number: KP - 99 - 02: WT- 86- C- 11. Unpublished study 05 - May 1999 prepared by Elf Atochem. 316 p. {OP PTS 860.1400} Dionne, E.; Sharp, J.; Formella, T. (1999) Dipotassium Salt of Endothall: A Freshwater 44820102 Fish and Shellfish Magnitude of Residues Study in a Static Aquatic System: Lab Project Number: KP - 97 - 14: 52897/171.4/FIFRA: EN1115.95. Unpublished study prepared by Elf 05 - May 1999 Atochem and ABC Laboratories, Inc. 213 p. {OPPTS 860.1400} 

### 15144820103 Biever, R. (1998) Hydrothol 191: An Aquatic Dissipation Study for Aquatic Non - Crop Uses: Final Report: Lab Project Number: KP - 96- 14: 98- 1 - 7215: 12442- 0896- 6214- 330. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 164 p. 05 - May 1999 44820104 Giddings, J. (1999) Ecological Risk Assessment of Aquatic Herbicides Containing Endothall: Final Report: Lab Project Number: KP - 98 - 31: 98- 11 - 7564: 12442 - 0898 - 6271 - 251. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 64 p. 05 - May 1999 44828800 Elf Atochem North America (1999) Submission of Environmental Fate Data in Support of the Reregistration o f Endothall Acid and Salts Containing Products Aquathol K and Hydrothal 191. Transmittal of 2 Studies. 05 - May 1999 Singh, P.; Ritter, A.; Sharp, J. et al. (1999) Aquatic Dissipation Modeling of Endothall 44828801 Acid: Aquathol K Aquatic Herbicide and Hy drothol 191 Aquatic Algicide and Herbicide: Lab Project Number: ATO KP - 97 - 16: WEI 286.01. Unpublished study prepared by 05 - May 1999 Waterborne Environmental, Inc. 363 p. Williams, W.; Ritter, A.; Sharp, J. et al. (1999) An Evaluation of the Aquatic Dissipation 44828802 of Endothall Aquatic Product: Aquathol, K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: Lab Project Number: ATOKP - 98 - 32: WEI - 286.06. Unpublished 05 - May 1999 study prepared by Waterborne Environmental, Inc. 69 p. 4497 6700 Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the Reregistration of Endothall Acids and Salts Containing Product Hydrothol 191. Transmittal of 1 Study. 20 - Oct 1999 Drottar, K.; Martin, K.; Krueger, H. (199 9) Hydrothol 191: A 96 - Hour Toxicity Test with 44976701 the Marine Diatom (Skeletonema costatum): Final Report: Lab Project Number: 299A 104. Unpublished study prepared by Wildlife International , Ltd. 38 p. {OPPTS 20 - Oct 1999 850.5400} 45039500 Elf Atochem NorthAmerica, Inc. (2000) Submission of Residue Chemistry Data in Support of the Reregistration of Endothall and Endothall Salts. Transmittal of 1 Study. 28 -Jan 2000 45039501 Toth, J. (1999) Immunochemical Method for Residues of Endothall in Water: Lab Proje ct Number: KP - 023 - 00. Unpublished study prepared by Elf Atochem North America, Inc. 74 p. {OPPTS 850.7100} 28 -Jan 2000 45146300 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in Support of the Reregistration of Endothall Acid and its Salts. Transmittal of 2 Studies. 19 -Jun 2000 45146301 Ussary, J. (2000) DES -I- CATE II: Magnitude of the Residue of Endothall on Potatoes: Final Report: Lab Project Number: KP - 98 - 22: 22A - 98: 22B - 98. Unpublished study prepared by Elf Atochem NorthAmerica, Inc. 202 p. {OPPTS 860.1500} 19 -Jun 2000 Ussary, J. (2000) DES -I- CATE II: Magnitude of the Residue of Endothall on Potato 45146302 Processing Fractions: Final Report: Lab Project Number: KP - 98 - 23: 44884: 23A - 98. Unpublished study prepared by El f Atochem North America, Inc. 162 p. {OPPTS 19 -Jun 2000 860.1520} 45764300 Cerexagri, Inc. (2002) Submission of Risk and Exposure Assessment Data in Support of the Registration of Endothall Aquatic Herbicides. Transmittal of 1 Study. 25 - Sep 2002 457643 01 Davis, C.; Ampofo, S. (2002) Exposure and Risk Assessment for Persons Reentering Non - Food Areas Treated with Endothall Aquatic Herbicides via Irrigation Water. Unpublished study prepared by Cerexagri, Inc. 26 p. 25 - Sep 2002 92061000 Agchem Division - Pe nnwalt Corp. (1990) Reregistration Phase 3 Response: Mono(N,N dimethyl alkyl* amine) endothall (7- ocabicyclo(2. 2. 25 - May 1990 

### 15292061001 Shellenberger, T. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 00035237. Hydrothol 191 - Acute Oral LD5 0 Test - Bobwhite Quail: Project No. 110 - 115.: 11 p. 25 - May 1990 92061002 Shellenberger, T. (1990) Agchem Division - Pennwalt Corp. Phase 3 Summary of MRID 00035240. Eight - day Dietary LC50 of Hydrothol 191 to Bobwhite Quail: Project No. 110 ­ 112.: 12 p. 25 - M ay 1990 92061999 Agchem Division - Pennwalt Corp. (1990) Reregistration Phase 3 Response: Mono(N,N dimethyl alkyl amine) endothall (7 - ocabicyclo(2. 2. Correspondence and Supporting Material. 25 - May 1990



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### G. EPA's Batching of Endothall Products for Meeting Acute Toxicity Data Require ments for Reregistration In an effort to reduce the time, resources and number of animals needed to fulfill the acute toxicity data requirements for reregistration of products containing Endothall as the active ingredient, the Agency has batched products which can be considered similar for purposes of acute toxicity. Factors considered in the sorting process in clude each product's active and inert ingredients (identity, percent composition and biological activity), type of formulation (e.g., emulsifiable concentrate, aerosol, wettable powder, granular, etc.), and labeling (e.g., signal word, use classification, precautionary labeling, etc.). Note that the Agency is not describing batched products as "substantially similar" since some products within a batch may not be considered chemically similar or have identical use patterns. Using available information, batching has been accomplished by the process described in the preceding paragraph. Notwith - standing the batching process, the Agency reserves the right to require, at any time, acute toxicity data for an individual product should the need arise. Registra nts of products within a batch may choose to cooperatively generate, submit or cite a single battery of six acute toxicological studies to represent all the products within that batch. It is the registrants' option to participate in the process with all ot

her registrants, only some of the other registrants, or only their own products within a batch, or to generate all the required acute toxicological studies for each of their own products. If a registrant chooses to generate the data for a batch, he/she mu st use one of the products within the batch as the test material. If a registrant chooses to rely upon previously submitted acute toxicity data, he/she may do so provided that the data base is complete and valid by today's standards (see acceptance criteria attached), the formulation tested is considered by EPA to be similar for acute toxicity, and the formulation has not been significantly altered since submission and acceptance of the acute toxicity data. Regardless of whether new data is generated or ex isting data is referenced, registrants must clearly identify the test material by EPA Registration Number. If more than one confidential statement of formula (CSF) exists for a product, the registrant must indicate the formulation actually tested by identi fying the corresponding CSF. In deciding how to meet the product specific data requirements, registrants must follow the directions given in the Data Call - In Notice and its attachments appended to the RED. The DCI Notice contains two response forms which are to be completed and submitted to the Agency within 90 days of receipt. The first form, "Data Call - In Response," asks whether the registrant will meet the data requirements for each product. The second form, "Requirements Status and Registrant's Resp onse," lists the product specific data required for each product, including the standard six acute toxicity tests. A registrant who wishes to participate in a batch must decide whether he/she will provide the data or depend on someone else to do so. If a registrant supplies the data to support a batch of products, he/she must select one of the following options: Developing Data 204

### (Option 1), Submitting an Existing Study (Option 4), Upgrading an Existing Study (Option 5) or Citing an Existing Study (Option 6 ). If a registrant depends on another's data, he/she must choose among: Cost Sharing (Option 2), Offers to Cost Share (Option 3) or Citing an Existing Study (Option 6). If a registrant does not want to participate in a batch, the choices are Options 1, 4, 5 or 6. However, a registrant should know that choosing not to participate in a batch does not preclude other registrants in the batch from citing his/her studies and offering to cost share (Option 3) those studies. Ten products were found which contain Endothall as the active ingredient. These products have been placed into two batches and a no batch group in accordance with the active and inert ingredients and type of formulation. Batching Instructions : No Batch: Each product in this Batch should g enerate their own data. EPA Reg. No. 4581 - 204 may rely on acute data used to support batch 2. NOTE: The technical acute toxicity values included in this document are for informational purposes only. The data supporting these values may or may not meet the current acceptance criteria. Batch # EPA Reg. No. Percent Active Ingredient 1 4581 - 172 11.2 4581 - 201 10.1 2 1448 - 352 53.0 4581 - 174 53.0 4581 - 380 53.0 4581 - 381 53.0 No Batch 4581 - 204 40.3 4581 - 257 75 4581 - 284 15.9 4581 - 388 63.0

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### H. List of Registrants Sent Data Call - Ins Technical Registrants Sent Generic Data Call - In: 1. Cerexagri, Inc. End - Use Registrants Sent Product Data Call - In 1. Cere xagri, Inc. 2. Buckman Laboratory, Inc.

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### I. List of Available Related Documents and Electronically Available Forms Pesticide Registration Forms are available a t the following EPA internet site: http://www.epa.gov/opprd001/forms Pesticide Registration Forms (these forms are in PDF format and require the Acrobat reader) Instructions 1. Print our and complete the forms. (Note: Form numbers that are bolded can be filled out on your computer than printed.) 2. The completed form(s) should be submitted in hardcopy in accord with the existing policy. 3. Mail the forms, along with any additional documents necessary to comply with EPA regulations cov ering your request, to the address below or the Document Processing Desk. DO NOT fax or e - mail any form containing 'Confidential Business Information' or 'Sensitive Information'. If you have any problems accessing these forms, please contact N icole Williams at (703) 308 - 5551 or by email at williams.nicole@epa.gov The following Agency Pesticide Registration Forms are currently available via the internet at the following locations: 8570- 1 Application for Pesticide Registration/Amendment http://www.epa.gov/opprd001/forms/8570 - 1.pdf 8570- 4 Confidential Statement of Formula http://www.epa.gov/opprd001/forms/8570 - 4.pdf 8570- 5 Notice of Supplemental Registration of Distribution of a Registered Pesticide Product http://www.epa.gov/opprd001/forms/8570 - 5.pdf 8570- 17 Application for an Experimental Use Perm it http://www.epa.gov/opprd001/forms/8570 - 17.pdf 8570- 25 Application for/Notification of State Registration of a Pesticide To Meet a Special Local Need http://www.epa.gov/opprd001/forms/8570 - 25.pdf 8570- 27 Formulator’s Exemption Statement http://www.epa.gov/opprd001/forms/8570 - 27.pdf 8570- 28 Certification of Compliance with Data Gap Procedures http://www.epa.gov/opprd001/forms/8570 - 28.pdf 8570- 30 Pesticide Registration Maintenance Fee Filing http://www.epa.gov/opprd001/forms/8570 - 30.pdf 8570- 32 Certification of Attempt to Enter into an Agreement with other Registrants for Development of Data http://www.epa.gov/o pprd001/forms/8570 - 32.pdf 8570- 34 Certification with Respect to Citations of Data (in PR Notice 98 - 5) http://www.epa.gov/opppmsd1/PR_Notices/pr98 - 5.pdf 

### 2078570- 35 Data Matrix (in PR Notice 98- 5) http://www.epa.gov/opppmsd1/PR_Notices/pr98 - 5.pdf 8570- 36 Summary of the Physical/Chemical Properties (in PR http://www.epa.gov/opppmsd1/PR_Notices/pr98 - Notice 98 - 1) 1.pdf 8570- 37 Self - Certification Statement for the Physical/Chemical http://www.epa.gov/opppms d1/PR_Notices/pr98 - Properties (in PR Notice 98- 1) 1.pdf 

### Pesticide Registration Kit: www.epa.gov/pesticides/registrationkit/ . Dear Registrant: For your convenience, we have assembled an online registration kit that contains the following pertin ent forms and information needed to register a pesticide product with the U.S. Environmental Protection Agency’s Office of Pesticide Programs (OPP): 1. The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Federal Food, Drug and Cosmetic Act (FFDCA) as Amended by the Food Quality Protection Act (FQPA) of 1996. 2. Pesticide Registration (PR) Notices a. 83 - 3 Label Improvement Program

— Storage and Disposal Statements b. 84 - 1 Clarification of Label Improvement Program c. 86 - 5 Standard Format for Data Submitted under FIFRA d. 87 - 1 Label Improvement Program for Pesticides Applied through Irrigation Systems (Chemigation) e. 87 - 6 Inert Ingredients in Pesticide Products Policy Statement f. 90 - 1 Inert Ingredients in Pesticide Products; Revised Policy Statement g. 95 - 2 Notifications, Non - notifications, and Minor Formulation Amendments h. 98 - 1 Self Certification of Product Chemistry Data with Attachments (This document is in PDF format and requires the Acrobat reader.) Other PR Notices can be found at http://www.epa.gov/opppmsd1/PR_Notices . 3. Pesticide Product Registration Application Forms (These forms are in PDF format and will require the Acrobat reader.) a. EPA Form No. 8570 - 1, Application for Pesticide Registration/Amendment b. EPA Form No. 8570 - 4, Confidential Statement of Formula 208

### c. EPA Form No. 8570 - 27, Formulator’s Exemption Statement d. EPA Form No. 8570 - 34, Certification with Respect to Citations of Data e. EPA Form No. 8570 - 35, Data Matrix 4. General Pesticide Information (Some of these forms are in PDF format and will require the Acrobat reader.) a. Registration Division Personnel Contact List b. Biopestic ides and Pollution Prevention Division (BPPD) Contacts c. Antimicrobials Division Organizational Structure/Contact List d. 53 F.R. 15952, Pesticide Registration Procedures; Pesticide Data Requirements (PDF format) e. 40 CFR Part 156, Labeling Requirements for Pesticides and Devices (PDF format) f. 40 CFR Part 158, Data Requirements for Registration (PDF format) g. 50 F.R. 48833, Disclosure of Reviews of Pesticide Data (November 27, 1985) Before submitting your application for registrati on, you may wish to consult some additional sources of information. These include: 1. The Office of Pesticide Programs’ Web Site 2. The booklet “General Information on Applying for Registration of Pesticides in the United States”, PB92 - 221811, availa ble through the National Technical Information Service (NTIS) at the following address: National Technical Information Service (NTIS) 5285 Port Royal Road Springfield, VA 22161 The telephone number for NTIS is (703) 605 - 6000. Please note that EPA is currently in the process of updating this booklet to reflect the changes in the registration program resulting from the passage of the FQPA and the reorganization of the Office of Pesticide Programs. We anticipate that this publication will become available during the Fall of 1998. 3. The National Pesticide Information Retrieval System (NPIRS) of Purdue University’s Center for Environmental and Regulatory Information Systems. This service does charge a fee for subscriptions and custom searches. You can contact NPIRS by telephone at (765) 494 - 6614 or through their Web site. 209

### 4. The National Pesticide Telecommunications Network (NPTN) can provide information on active ingredients, uses, toxicology, and chemistry of pesticides. You can contact NPTN by telephone at (800) 858 - 7378 or through their Web site: ace.orst.edu/info/nptn. The Agency will return a notice of receipt of an application for registration or amended registration, experimental use permit, or amendment to a petition if the applicant or petitioner encloses with his submission a stamped, self - addressed postcard. The postcard must contain the following entries to be completed by OPP: Date of receipt EPA identifying number Product Manager Assignment Other identifying information may be included by the applicant to link the acknowledgment of receipt to the specific application submitted. EPA will stamp the date of receipt and provide the EPA identifying File Symbol or petition number for the new submission. The identifying numb er should be used whenever you contact the Agency concerning an application for registration, experimental use permit, or tolerance petition. To assist us in ensuring that all data you have submitted for the chemical are properly coded and assigned to your company, please include a list of all synonyms, common and trade names, company experimental codes, and other names which identify the chemical (including “blind” codes used when a sample was submitted for testing by commercial or academic facilities). Pl ease provide a CAS number if one has been assigned.

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