United States Prevention, Pesticides EPA 738-R-05-008 

Environmental Protection and Toxic Substances September 2005 

Agency (7508C) 

Reregistration 

Eligibility Decision for 

Endothall 

i 
Reregistration Eligibilit y Decision (RED) Document for 

Endothall 

List B 

Case Number 2245 

Approved by: Date: 

Debra Edwards, Ph. D. 

Director 

Special Review and Reregistration Division 

ii 
Table of Contents 

Endothall Reregistration Eligibility Decision Team.............................................................i

Glossary of Terms and Abbreviations ................................................................................ ii

Abstract ...............................................................................................................................iv

I. Introduction...................................................................................................................... 1

II. Chemical Overview........................................................................................................ 2

A. Endothall and Salts Nomenc lature ............................................................................. 3

B. Use Sites..................................................................................................................... 3

C. Formulations ............................................................................................................... 3

D. Methods of application............................................................................................... 3

E. Use rates ..................................................................................................................... 4

F. Annual usage ............................................................................................................... 4

G. Tolerances in Use Profile ........................................................................................... 4

H. Technical Registrant ................................................................................................... 5

III. Summary of Risk Assessment ...................................................................................... 5

A. Human Health Risk Assessment ................................................................................ 5

1. Hazard Profile ......................................................................................................... 5

2. Dietary Risk (Food) ................................................................................................ 7

a. Acute Dietary Risk (Food ................................................................................... 8

b. Chronic Dietary Risk (Food) .............................................................................. 8

3. Cancer Dietary Risk (Food) .................................................................................. 10

4. Drinking Water Dietary Risk ................................................................................ 10

a. Aquatic Uses ..................................................................................................... 10

b. Terrestrial Uses ................................................................................................. 12

5. Chronic Risk from Food Plus Drinking Water ..................................................... 12

6. Residential Risk .................................................................................................... 13

7. Aggregate Risk...................................................................................................... 14

8. Occupational Risk................................................................................................. 14

a. Occupational Handler Summary....................................................................... 15

i. Terrestrial Applications ................................................................................. 15

ii. Aquatic Applications .................................................................................... 15

iii. Cooling Tower (Biocide) Applications ....................................................... 16

b. Post-application Occupational Risk .................................................................. 16

9. Human Incident Summary.................................................................................... 17

B. Ecological Risk......................................................................................................... 17

1. Environmental Fate and Transport........................................................................ 17

2. Terrestrial Organism Risk..................................................................................... 18

a. Risks from Use of Endothall N, N-dimethylalkylamine Salt............................ 18

3. Aquatic Organism Risk......................................................................................... 19

a. Risks from Use of Endothall N, N-dimethylalkylamine Salt............................ 19

b. Risks from Use of Endothall Dipotassium Salt ................................................ 20

c. Risks from Endothall Acid ................................................................................ 20

4. Risk to Endangered Species.................................................................................. 21

a. Risks from Use of Endothall N, N-dimethylalkylamine Salt............................ 21

b. Risks from Use of Endothall Dipotassium Salt ................................................ 22

iii 
IV. Risk Management, Reregistration, and Tolerance Reassessment Decision............... 22

A. Determination or Reregistration Eligibility............................................................. 22

B. Public Comments and Responses............................................................................. 23

C. Regulatory Position.................................................................................................. 23

1. Food Quality Protection Act Findings.................................................................. 23

a. "Risk Cup" Determination ................................................................................ 23

b. Determination of Safety to U.S. Population (Including Infants and Children) 24

c. Endocrine Disruptor Effects.............................................................................. 24

d. Cumulative Risks .............................................................................................. 25

2. Tolerance Summary.............................................................................................. 25

a. Tolerances Currently Listed and Tolerance Reassessme nt ............................... 27

D. Regulatory Rationale................................................................................................ 28

a. Dietary Risk Mitigation (food and drinking water) .......................................... 28

1. Human Health Risk Management......................................................................... 29

a. Occupational Risk Mitigation ........................................................................... 29

b. Residential Risk Mitigation .............................................................................. 29

2. Environmental Risk Management......................................................................... 30

a. Dipotassium Salt ............................................................................................... 30

b. N, N-dimethylalkylamine Salt .......................................................................... 30

3. Significance of Endothall Use............................................................................... 30

4. Other Labeling Requirements............................................................................... 31

5. Threatened and Endangered Species Considerations............................................ 32

a. The Endangered Species Program..................................................................... 32

b. General Risk Mitigation.................................................................................... 32

V. What Registrants Need to Do....................................................................................... 33

A. Manufacturing Use Products.................................................................................... 34

1. Additional Generic Data Requirements................................................................ 34

2. Labeling for Technical and Manufacturing Use Products.................................... 35

B. End-Use products ..................................................................................................... 36

1. Additional Product-Specific Data Requirements .................................................. 36

2. Labeling for End-Use Products............................................................................. 36

a. Label Changes Summary Table ........................................................................ 36

VI. Appendices.................................................................................................................. 47

A. Table of Use Patterns for Endothall ............................................................................. 48

B.Generic Data Requirements and Studies Used to Make the Reregistration Decision63

C. Technical Support Documents ................................................................................. 70

D. Bibliography............................................................................................................. 73

E. Generic Data Call-In............................................................................................... 154

F. Product Specific Data Call-In................................................................................. 177

G. EPA's Batching of Endothall Products for Meeting Acute Toxicity Data 

Requirements for Reregistration................................................................................. 204

H. List of Registrants Sent Data Call-Ins .................................................................... 206

I. List of Available Related Documents and Electronically Available Forms............ 207

iv 
Endothall Reregistration Eligibility Decision Team 

Special Review and Reregistration Division 

Mika J. Hunter 

Anne Overstreet 

Robert McNally 

Health Effects Division 

Robert Zendzian 

David Soderberg 

Seyed (Nader) Tadayon 

Louis (Gino) Scarano 

Environmental Fate and Effects Division 

Michelle Embry 

Michael Davy 

Dana Spatz 

Antimicrobial Division 

Kathryn Montaque 

Timothy Leighton 

Biological and Economic Analysis Division 

Bill Phillips 

TJ Wyatt 

Steve Jarboe 

Registration Division 

Joanne Miller 

Jim Stone 

i 
Glossary of Terms and Abbreviations 

AGDCI 

ai 

aPAD 

BCF 

CFR 

cPAD 

CSF 

CSFII 

DCI 

DEEM 

DFR 

DNT 

EC 

EDWC 

EEC 

EPA 

EUP 

FDA 

FIFRA 

FFDCA 

FQPA 

GLN 

IR 

LC50 

LD50 

LOC 

LOAEL 

MATC 

μg/g 

μg/L 

mg/kg/day 

mg/L 

MOE 

MRID 

MUP 

NOAEL 

OPP 

OPPTS 

PAD 

PCA 

PDP 

PHED 

PHI 

ppb 

PPE 

ppm 

Agricultural Data Call-In 

Active Ingredient 

Acute Population Adjusted Dose 

Bioconcentration Factor 

Code of Federal Regulations 

Chronic Population Adjusted Dose 

Confidential Statement of Formulation 

USDA Continuing Surveys for Food Intake by Individuals 

Data Call-In 

Dietary Exposure Evaluation Model 

Dislodgeable Foliar Residue 

Developmental Neurotoxicity 

Emulsifiable Concentrate Formulation 

Estimated Drinking Water Concentration 

Estimated Environmental Concentration 

Environmental Protection Agency 

End-Use Product 

Food and Drug Administration 

Federal Insecticide, Fungicide, and Rodenticide Act 

Federal Food, Drug, and Cosmetic Act 

Food Quality Protection Act 

Guideline Number 

Index Reservoir 

Median Lethal Concentration. A statistically derived concentration of a substance that 

can be expected to cause death in 50% of test animals. It is usually expressed as the 

weight of a substance per weight or volume of water, air, or feed, e.g., mg/l, mg/kg, or 

ppm. 

Median Lethal Dose. A statistically derived single dose that can be expected to cause 

death in 50% of the test animals when administered by the route indicated (oral, dermal, 

inhalation). It is expressed as a weight of substance per unit weight of animal, e.g., 

mg/kg. 

Level of Concern 

Lowest Observed Adverse Effect Level 

Maximum Acceptable Toxicant Concentration 

Micrograms Per Gram 

Micrograms Per Liter 

Milligram Per Kilogram Per Day 

Milligram Per Liter 

Margin of Exposure 

Master Record Identification Number. EPA's system for recording and tracking studies 

submitted. 

Manufacturing-Use Product 

No Observed Adverse Effect Level 

EPA Office of Pesticide Programs 

EPA Office of Prevention, Pesticides, and Toxic Substances 

Population Adjusted Dose 

Percent Crop Area 

USDA Pesticide Data Program 

Pesticide Handler's Exposure Data 

Pre-harvest Interval 

Parts Per Billion 

Personal Protective Equipment 

Parts Per Million 

ii 
PRZM/EXAMS 

RAC 

RED 

REI 

RfD 

RQ 

SCI-GROW 

SAP 

SF 

SLC 

TGAI 

USDA 

USGS 

UF 

UV 

WPS 

Tier II Surface Water Computer Model 

Raw Agriculture Commodity 

Reregistration Eligibility Decision 

Restricted Entry Interval 

Reference Dose 

Risk Quotient 

Tier I Ground Water Computer Model 

Science Advisory Panel 

Safety Factor 

Single Layer Clothing 

Technical Grade Active Ingredient 

United States Department of Agriculture 

United States Geological Survey 

Uncertainty Factor 

Ultraviolet 

Worker Protection Standard 

iii 
Abstract 

This document presents the Environmental Protection Agency's (hereafter 

referred to as EPA or the Agency) decision regarding the reregistration eligibility of the 

registered uses of endothall. The Agency has determined that endothall is eligible for 

reregistration. Endothall is used as an aquatic herbicide, a desiccant, and a biocide. 

Endothall is applied as either the dipotassium salt or the N, N-dimethylalkylamine salt. 

There are currently seven tolerances established for endothall. The Agency has 

conducted human health and environmental fate and ecological effect risk assessments 

for endothall and reassessed all the existing tolerances. The risk conclusions of these 

assessments are summarized below. 

In the human health risk assessment, chronic dietary risks (food and drinking 

water) do not exceed the Agency's level of concern, although drinking water risk for 

infants less than one year old is at the level of concern. However, the Agency believes 

that this risk estimate is the result of conservative assumptions and is discussed in detail 

in section III.5 of this document. Aggregate risks (food, drinking water, and residential 

exposure) also do not exceed the Agency's level of concern. To ensure that endothall 

exposures from drinking water do not result in risks of concern, the Agency is requiring 

that direct applications to water not be applied less than 600 feet from an active drinking 

water intake. 

For terrestrial uses of endothall, all risks calculated for short-term and 

intermediate-term occupational exposures are below the Agency's level of concern with 

the exception of mixing and loading liquids for aerial applications. The Agency is 

requiring that workers mixing and loading liquids for aerial applications wear an 80% 

(PF5) respirator (NIOSH TC-21C). All risks for short-term and intermediate-term 

exposures from mixing, loading, and applying liquid formulations to aquatic use sites are 

below the Agency's level of concern when workers wear an 80% (PF5) respirator 

(NIOSH TC-21C). All risks for short-term exposures from loading and applying granular 

formulations for aquatic applications are below the Agency's level of concern when 

workers wear baseline protective equipment. For intermediate-term exposures from 

loading and applying granular formulations for aquatic applications, risks are of concern 

to the Agency. To protect workers in this scenario, workers are required to wear a 90% 

respirator (PF10 elastomeric half-face respirator with the appropriate cartridge, NIOSH 

TC-23C or NIOSH TC-14G). All occupational risks from use of endothall as a biocide in 

cooling towers are below the Agency's level of concern. 

Technical endothall is classified as a severe dermal irritant. However, this 

regulatory decision does not include specific mitigation to address these dermal effects. 

Appropriate worker protections and label language will be established based on end-use 

product acute toxicity during product reregistration. Product reregistration follows active 

ingredient reregistration. A 48-hour re-entry interval is currently on labels for terrestrial 

uses and will be retained. In addition, a double notification statement to further protect 

workers will be added to endothall labels intended for terrestrial use. 

iv 
Ecological risks were identified as a result of endothall use in terrestrial and 

aquatic settings. To potentially reduce risks to non-target plants and organisms, the 

Agency is requiring that endothall labels differentiate application rates for small and large 

applications of endothall dipotassium salt. Labels will specify that higher rates are only 

to be used for small, spot treatments, and lower rates are to be used for larger treatments. 

In addition, the use of N, N-dimethylalkylamine salt in lakes, streams, and ponds will be 

limited to algae, Hygrophila, Vallisneria, Hydrilla, Cabomba, bur-weed, Elodea 

canadensis, and Brazilian elodea. 

v 
I. Introduction

The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) was amended 

in 1988 to accelerate the reregistration of products with active ingredients registered prior 

to November 1, 1984 and amended again by the Pesticide Registration Improvement Act 

of 2003 to set time frames for the issuance of Reregistration Eligibility Decisions. The 

Act calls for the development and submission of data to support the reregistration of an 

active ingredient, as well as a review of all submitted data to the U.S. Environmental 

Protection Agency (EPA or the Agency). Reregistration involves a thorough review of 

the scientific database underlying a pesticide's registration. The purpose of the Agency's 

review is to reassess the potential hazards arising from the currently registered uses of a 

pesticide; to determine the need for additional data on health and environmental effects; 

and to determine whether or not the pesticide meets the "no unreasonable adverse effects" 

criteria of FIFRA. 

On August 3, 1996 the Food Quality Protection Act of 1996 (FQPA) was 

signed into law. This Act amended FIFRA and the Federal Food Drug and Cosmetic Act 

(FFDCA) to require reassessment of all existing tolerances for pesticides in food. FQPA 

also requires EPA to review all tolerances in effect on August 3, 1996 by August 3, 2006. 

In reassessing these tolerances, the Agency must consider, among other things, aggregate 

risks from non-occupational sources of pesticide exposure, whether there is increased 

susceptibility among infants and children, and the cumulative effects of pesticides that 

have a common mechanism of toxicity. When the Agency determines that aggregate 

risks are not of concern and concludes that there is a reasonable certainty of no harm 

from aggregate exposure, the tolerances are considered reassessed. EPA decided that, for 

those chemicals that have tolerances and are undergoing reregistration, tolerance 

reassessment would be accomplished through the reregistration process. 

As mentioned above, FQPA requires EPA to consider "available 

information" concerning the cumulative effects of a particular pesticide's residues and 

"other substances that have a common mechanism of toxicity" when considering whether 

to establish, modify, or revoke a tolerance. Potential cumulative effects of chemicals 

with a common mechanism of toxicity are considered because low-level exposure to 

multiple chemicals causing a common toxic effect by a common mechanism could lead 

to the same adverse health effect as would a higher level of exposure to any one of these 

individual chemicals. For information regarding EPA's efforts to determine which 

chemicals have a common mechanism of toxicity and to evaluate the cumulative effects 

of such chemicals, see the policy statements released by EPA's Office of Pesticide 

Programs concerning common mechanism determinations and procedures for cumulating 

effects from substances found to have a common mechanism on EPA's website at 

http://epa.gov/pesticides/cumulative/. 

The Agency has found no information indicating endothall shares a 

common mechanism of toxicity with other substances. Endothall does not appear to 

1
produce a toxic metabolite produced by other substances. Therefore, for the purposes of 

tolerance reassessment and a decision on reregistration eligibility, EPA has not assumed 

that endothall shares a common mechanism of toxicity with other compounds. In the 

future, if additional information suggests endothall shares a common mechanism of 

toxicity with other compounds, additional testing may be required and a cumulative 

assessment may be necessary. 

This document presents EPA's revised human health and ecological risk 

assessments, its progress toward tolerance reassessment, and the reregistration eligibility 

decision for endothall. The document consists of six sections. Section I contains the 

regulatory fr amework for reregistration/tolerance reassessment. Section II provides a 

profile of the use and usage of the chemical. Section III gives an overview of the revised 

human health and ecological risk assessments based on data, public comments, and other 

information received in response to the preliminary risk assessments. Section IV presents 

the Agency's reregistration eligibility and risk management decisions. Section V 

summarizes label changes necessary to implement the risk mitigation measures outlined 

in Section IV. Section VI provides information on how to access related documents. 

Finally, the Appendices list related information and supporting documents. The 

preliminary and revised risk assessments for endothall are available in the Public Docket, 

under docket number OPP-2004-0370 and on the Agency's web page, 

http://www/epa.gov/edockets. 

II. Chemical Overview

Endothall is in the dicarboxylic acid class of chemicals. Endothall is applied as 

either a dipotassium salt or an N, N-dimethylalkylamine salt. Endothall acid is not 

directly applied to use sites; it is formed as a breakdown product resulting from 

application of the salt forms. The amine salt is the only form applied terrestrially, while 

both the dipotassium and amine salt are applied to aquatic use sites. The amine salt is 

also used to control algae and invasive mollusks in cooling towers. The majority of 

endothall is used in aquatic environments. 

Endothall acid is a selective contact herbicide. Endothall acid works by 

interfering with plant respiration, by affecting protein and lipid biosynthesis, and by 

disrupting plant cell membranes. 

2
A. Endothall and Salts Nomenclature 

Endothall, acid 

Molecular Formula C8H10O5 

CAS Name 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 

CAS Number 145-73-3 

PC Code 038901 

Endothall, dipotassium salt 

Molecular Formula C8H8K2O5 

CAS Name N/A 

CAS Number 2164-07-0 

PC Code 038904 

Endothall, mono-N,N-dimethylalkylamine salt 

Molecular Formula C10H17NO5 

CAS Name N/A 

CAS Number 66330-88-9 

PC Code 038905 

B. Use Sites 

• Endothall is used as an aquatic herbicide to control submerged aquatic 

vegetation and algae in lakes, ponds, and irrigation canals. 

• Endothall is also used as a desiccant on potatoes, hops, cotton, clover, and 

alfalfa. Tolerances are established for sugar beets and rice straw, although 

current labels do not allow applications to these crops. 

• Endothall has one biocide use to control mollusks and algae in cooling 

towers/systems. 

C. Formulations 

• Formulated as either a granular or a soluble concentrate (liquid). 

D. Methods of application 

• For aquatic applications, endothall dipotassium salt and endothall N, Ndimethylalkylamine salt can be applied as a granular or a liquid. Granular 

applications are made using centrifugal or blower-type spreaders that are 

mounted to boats. Granular formulations can also be applied to aquatic 

sites by spreader equipment attached to helicopters. Liquid applications 

are made using low pressure hand wand sprayers, hand-gun sprayers, or 

3
direct metering systems. Aerial application of liquids to aquatic sites is 

prohibited. 

• For terrestrial applications, endothall is applied as a liquid. Terrestrial 

liquid applications can be made with either ground or aerial equipment. 

Only endothall N, N-dimethylalkylamine salt is used on terrestrial sites. 

E. Use rates 

• Maximum single application rates are 5 ppm for aquatic applications and 2 

lbs acid equivalents/Acre for terrestrial applications. Application rates of 

both the salt forms of endothall are expressed as acid equivalents (ae) to 

equalize the application rates in terms of the acid. 

F. Annual usage 

• In terms of pounds used, endothall is most readily used as an aquatic 

herbicide. For terrestrial endothall uses, the majority of use is on potatoes 

(approximately 5% crop treated) and cotton (less than 2.5% crop treated). 

Of the two forms of endothall, the N, N-dimethylalkylamine salt accounts 

for the most use. 

G. Tolerances in Use Profile 

• There are currently five tolerances for endothall and its salts listed in CFR 

§ 180.293(a)(1) on cotton seed (0.1 ppm), hops (0.1 ppm), potato (0.1 

ppm), rice grain (0.05 ppm), and rice straw (0.05 ppm). One tolerance is 

listed in CFR § 180.319 for sugar beets (0.2 ppm). 

• A tolerance is currently listed for potable water (0.2 ppm, CFR § 

180.293(a)(2). The Agency is proposing that this tolerance be revoked. 

Currently, EPA’s Office of Water has an MCL established for endothall. 

• The Agency is proposing tolerances for cotton gin byproducts, animal 

commodities, processed commodities, and irrigated crops. When 

acceptable data are received these tolerances will be established. 

• The registrant has proposed tolerances for fish and shellfish. This action 

is not incorporated into this document and will be addressed in a separate 

action. However, a fresh water finfish residue level of 0.1 ppm was 

included in the dietary exposure assessment. Current food consumption 

models cannot include residues in freshwater shellfish adequately; so 

freshwater shellfish were not incorporated into the current assessment, and 

were considered as a negligible source of residues. 

4
H. Technical Registrant 

• Cerexagri, Inc. 

III. Summary of Risk Assessment

A. Human Health Risk Assessment

1. Hazard Profile 

(For a complete discussion, see section 4 of Endothall: HED Chapter of the 

Reregistration Eligibility Decision Document, Corrected Following Pub lic Comments, 

dated September 30, 2005.) 

The toxicological database for endothall is considered complete. 

Endothall is Toxicity Category I by the oral, and ocular routes, and is a skin sensitizer. 

For dermal and inhalation toxicity, endothall is categorized as mildly toxic. 

For dermal exposure, a toxicity endpoint was not identified, and a dermal risk 

assessment was not conducted since endothall is so toxic at the portals of entry and is 

therefore self-limiting. In the 21-day dermal toxicity study, in addition to weight loss, 

severe local effects were observed at the lowest dose tested, 30 mg/kg/day. Total body 

weight gain was also inhibited. The study indicated that systemic and local effects were 

co-occurant. Therefore, the Agency has determined that endothall will be classified as a 

severe dermal irritant. Label requirements addressing dermal effects through double 

notification will be placed on technical and end-use products. End-use products 

generally contain a lower percentage of active ingredient and it is appropriate to consider 

additional label requirements relating to endothall's dermal effects during product 

reregistration. 

Endothall is not a neurotoxicant, nor does it induce developmental toxicity. 

Endothall is classified as "not likely to be carcinogenic to humans" and has no mutagenic 

potential. Endothall does not bioaccumulate. 

Table 1. Acute Toxicity Data for Endothall 

Guideline Number 

Study Type 

MRID Number Toxicity Category 

870.1100 Acute Oral Toxicity 42289201 I 

870.1200 Acute Dermal Toxicity 42289202 III 

870.1300 Acute Inhalation Toxicity 42169501 II 

870.2400 Acute Eye Irritation 42289203 I 

870.2500 Acute Dermal Irritation 42289204 

(unacceptable) 

Ia 

870.2600 Skin Sensitization 41871901 Yes 

a. Endothall has been shown to be a skin irritant in a preliminary range finding study for the dermal 

absorption study (42169503) and the 21-day dermal toxicity study (43465201). This information is 

considered sufficient to classify endothall as a severe dermal irritant. 

5 
Although endpoints for all exposure scenarios were selected from the same study, 

it is important to note that for each scenario, different toxicity endpoints are appropriate. 

The two short-term exposure scenarios (1-30 days, incidental oral and short-term 

inhalation) use a separate endpoint (NOAEL of 9.4 mg/kg/day) based on decreases in 

body weight in offspring of endothall-treated parents. The remaining, longer-term 

scenarios use a more conservative value (LOAEL of 2 mg/kg; divided by 3 to extrapolate 

to an estimated NOAEL of 0.7 mg/kg) to accommodate the longer exposure scenarios. 

Because an inhalation study is not currently available (a 28-day inhalation study is being 

required), the inhalation exposure scenario uses an oral study assuming 100% absorption. 

Table 2. Summary of Toxicological Doses and Endpoints for Endothall Used in the 

Human Health Risk Assessment 

Exposure Scenario Dose Used in Risk Special FQPA SF* Study and Toxicological 

Assessment, UF and Level of Concern Effects 

for Risk Assessment 

Acute Dietary An appropriate endpoint attributable to a single dose was not available from any 

(All Populations) study, including the prenatal developmental toxicity study in rats. An acute RfD 

was not established. 

Chronic Dietary 

(All Populations) 

LOAEL = 22 

mg/kg/day 

FQPA SF = 1X 

cPAD = 

2-generation reproduction study 

in rats 

chronic RfD 

UF = 300 FQPA SF LOAEL of 2 mg/kg/day based 

(10X for intraspecies on proliferative lesions of the 

variations, 10X for = 0.007 mg/kg/day gastric epithelium in both sexes. 

interspecies 

differences, and 3X (MRID 43152101) 

for extrapolation 

from LOAEL to 

NOAEL) 

Chronic RfD = 

0.007 mg/kg/day 

Short-term NOAEL=9.41 Residential MOE = 100 2-generation reproduction study 

Incidental Oral mg/kg/day in rats 

(1-30 days) 

UF = 100 LOAEL of 60 mg/kg/day based 

(10X for intraspecies on decreased pup body weight 

variations, 10X for in both sexes on Day 0 of 

interspecies second and third generations. 

differences) 

(MRID 43152101) 

Intermediate-term 

Incidental Oral (1-6 

months) 

LOAEL= 2 2 

mg/kg/day 

Residential MOE = 300 2-generation reproduction study 

in rats 

UF = 300 

(10X for intraspecies 

variations, 10X for 

LOAEL of 2 mg/kg/day based 

on proliferative lesions of the 

gastric epithelium in both sexes. 

interspecies 

differences, and 3X 

for extrapolation 

(MRID 43152101) 

from LOAEL to 

NOAEL) 

6
Exposure Scenario Dose Used in Risk Special FQPA SF* Study and Toxicological 

Assessment, UF and Level of Concern Effects 

for Risk Assessment 

Short-term NOAEL=9.41 Residential MOE = 100 2-generation reproduction study 

Inhalation mg/kg/day in rats 

(1-30 days) Occupational MOE = 

UF= 100 100 LOAEL of 60 mg/kg/day based 

(10X for intraspecies on decreased pup body weight 

variations, 10X for (both sexes) on Day 0 in both 

interspecies F1 and F2 generations. 

differences) 

(MRID 43152101) 

(inhalation absorption 

rate is assumed to be 

100% of oral dose; 

default assumption) 

Intermediate-Term 

Inhalation

LOAEL = 2 2 

mg/kg/day 

Residential MOE = 300 2-generation reproduction study 

in rats 

 (1-6 months) 

and Long-Term 

Inhalation 

UF = 300 

(10X for intraspecies 

Occupational MOE = 

300 LOAEL of 2 mg/kg/day based 

on proliferative lesions of the 

variations, 10X for 

interspecies 

differences, and 3X 

gastric epithelium in both sexes. 

(MRID 43152101) 

for extrapolation 

from LOAEL to 

NOAEL) 

Cancer (oral, Classified as “not likely to be carcinogenic to humans” 

dermal, inhalation) (MRID 41040301, 40685301, 43608301) 

UF= uncertainty factor, FQPA SF = Special FQPA safety factor, LOAEL = lowest observed adverse effect 

level, PAD = population adjusted dose (c = chronic), RfD = reference dose, MOE = margin of exposure 

1. The NOAEL of 9.4 mg/kg/day is derived from the offspring LOAEL of 60 mg/kg/day for the endpoint 

referenced in the table. 

2. The LOAEL of 2 mg/kg/day is derived from the parental LOAEL of 2 mg/kg/day for the endpoint 

referenced in the table. 

2. Dietary Risk (Food)

(For a complete discussion, see Section 6.0 of Endothall: HED Chapter of the 

Reregistration Eligibility Decision Document, Corrected Following Pub lic Comments, 

dated September 30, 2005.) 

The dietary risk assessment incorporates both exposure to and toxicity of a given 

pesticide. The risk is expressed as a percentage of a maximum acceptable dose (i.e., the 

maximum dose which will result in no unreasonable adverse health effects). This dose is 

referred to as the population adjusted dose (PAD). The PAD is equivalent to the 

Reference Dose (RfD) divided by the special FQPA Safety Factor. EPA is concerned 

when estimated dietary risk exceeds 100% of the PAD. The endothall dietary risk 

assessment was performed using the Dietary Exposure Evaluation Model (DEEMTM). 

Table 2 above lists the endpoints used in the dietary risk assessment. 

7
The Special FQPA Safety Factor was reduced to 1X because there are no residual 

exposure uncertainties, no sensitivity to infants and children, and the toxicity database is 

essentially complete. The uncertainty factor (UF) for chronic dietary exposure to 

endothall was determined to be 300. This takes into consideration a factor of 10X for 

interspecies variation, 10X for intraspecies variation, and 3X for the lack of a NOAEL in 

the study used for endpoint selection. When eva luating the toxicological database for 

endothall, the primary effects are seen at the point of entry (i.e., oral) and the weight of 

evidence suggests that endothall will be of no developmental concern. This evidence 

includes the results of a developmental toxicity study with rats, where endothall did not 

induce developmental toxicity at any of the doses tested. Effects that were observed in 

developmental toxicity studies (decreased pup weight gain) are not considered to be 

developmental toxicity effects. Therefore, no additional uncertainty factors were added 

for the lack of a rabbit developmental toxicity study. However, a rabbit developmental 

toxicity study is being required as confirmatory data. 

Endothall metabolism results in either the formation of the monomethyl ester or 

complete decomposition into natural constituents of plant and animal tissues. The 

residues of concern in plants and animals are endothall and its monomethyl ester. 

a. Acute Dietary Risk (Food) 

No endpoint was identified for acute dietary exposures because the acute toxicity 

database is complete and does not suggest there is a potential acute risk concern. 

Normally, an acute hazard value is chosen from acute (non-lethal), subchronic, or 

developmental toxicity studies from which there is reasonable evidence that a single 

exposure can lead to a potential effect. Endothall is known to cause primarily local 

effects depending on the route of exposure. In the developmental rat study, there was 

evidence of a decrease in body weight gain in pregnant rats after a single exposure of 

endothall. However, this effect was coupled with a decrease in food consumption and the 

treated rats recovered by the end of gestation. At all time points, there was no difference 

in treated versus control body weights. Therefore, the available data suggests that a 

single exposure to endothall does not result in an effect of concern for risk assessment 

purposes. The Agency does not expect acute risks resulting from dietary exposure. 

b. Chronic Dietary Risk (Food)

The chronic dietary risk endpoint for all populations was selected from the twogeneration reproduction toxicity study using rats as the test subject. The endpoint of 

concern was proliferate lesions of the gastric epithelium, which was observed in both 

sexes. The Lowest Observed Adverse Effect Level (LOAEL) is 2 mg/kg/day in males 

and 2.3 mg/kg/day in females. 

For the chronic dietary exposure assessment, an estimate of the residue level in 

each food or food-form on the food commodity residue list is multiplied by the average 

daily consumption estimate for that food/food-form. The resulting residue consumption 

8
estimate is summed with the residue consumption estimates for all other food/food forms 

on the commodity residue list to arrive at the total average estimated exposure. Exposure 

is expressed in mg/kg body weight/day and risk is expressed as a percent of the chronic 

PAD (cPAD). 

Food items may be exposed to residues of endothall in two ways: via direct 

application, or via irrigation water previously treated with endothall. To assess residues 

on food from the two uses, two assessments were performed. One assessment took into 

consideration only exposure to crops that are directly treated with endothall. The second 

assessment incorporated exposure to crops directly treated with endothall and crops that 

were irrigated with endothall-treated water. To assess exposures from both of these 

scenarios, a DEEMTM analysis was performed. 

The results of the DEEMTM analysis using exposure from only directly treated 

crops was 1.2% of the cPAD for the general population. The most highly exposed 

population subgroup was children 3-5 years old with an exposure estimate of 3.0% of the 

cPAD. These results are based on tolerance level residues and 100% crop treated and are 

considered to be conservative estimates of chronic dietary risk. 

When calculating residues on crops irrigated with endothall-treated water, an 

assumption that all crops are irrigated with water containing endothall was initially used 

directly in the DEEMTM program. This assumption led to an overestimate of exposure 

from irrigated crops. Using the amount of endothall produced per year, and information 

from the U.S. Geological Survey concerning irrigation practices, the Agency was able to 

refine exposure estimates. To conservatively address errors in this estimation and to 

assure that regional and crop differences in irrigation, and differences in consumption of 

crops are taken into consideration, a percent of the crops irrigated with treated irrigation 

water was conservatively estimated to be 1%. The actual increase in exposure to 

endothall through irrigation should be less than 1% of that originally estimated by 

DEEMTM. Therefore, the results from the DEEMTM analysis for the portion of exposure 

due to irrigated crops were multiplied by a factor of 0.01. The results of the DEEMTM 

exposure analysis for exposure from directly treated crops and irrigated crops was 2.7% 

of the cPAD for the general population, and 7.8% cPAD for children 1-2 years old. 

Therefore, chronic dietary risks (food) are below the Agency's level of concern. 

For a complete discussion of exposure to endotha ll from consumption of irrigated 

crops, please see "Endothall and its salts: Addendum to Chronic Dietary Exposure 

Assessment for the Reregistration Eligibility Decision", dated September 29, 2005. 

9
Table 3. Summary of Chronic Dietary Exposure and Risk from Endothall (Directly 

Treated Crops and Crops Irrigated with 5 ppm Endothall) 

Population Subgroup Dietary Exposure % cPAD 

mg/kg/day 

General U.S. Population 0.000189 2.7 

Children 1-2 years old 0.000544 7.8 

3. Cancer Dietary Risk (Food)

The Agency has classified endothall as "not likely to be carcinogenic to humans" 

based on the lack of evidence of carcinogenicity in mice or rats. 

4. Drinking Water Dietary Risk

(For a complete discussion, see Section 6.2 of the Endothall: HED Chapter of the 

Reregistration Eligibility Decision Document, Corrected Following Pub lic Comments, 

dated September 30, 2005.) 

Drinking water exposure to pesticides can occur through groundwater and surface 

water contamination. EPA considers both acute (one day) and chronic (lifetime) drinking 

water risks and uses either modeling or actual monitoring data, if available, to estimate 

those risks. For endothall, only non-cancer chronic dietary exposure from drinking water 

was assessed. As previously stated, an endpoint for acute dietary exposure was not 

identified and acute dietary risks are not of concern to the Agency. For endothall, 

drinking water exposure takes into consideration potential exposure from terrestrial, 

aquatic, and industrial (biocide) uses. Also, endothall is considered "not likely to be 

carcinogenic in humans". 

a. Aquatic Uses

Direct applications to water were modeled assuming uniform application over an 

entire reservoir at the maximum labeled rate. Based on these assumptions, the peak 

(acute) concentration of endothall in surface water was estimated to be 5000 μg/L, and 

the annual mean (chronic) concentration was estimated to be 545 μg/L. EPA believes it 

is highly unlikely that concentrations of endothall would reach these levels in areas where 

surface water is directly used for drinking water for several reasons: 

• The assumption that 100% of a water body is treated with endothall at the 

maximum label rate is conservative and highly unlikely. Typically, 

endothall is applied as a peripheral treatment around boat docks and piers, 

so that only a small percentage of a water body is treated. 

• Endothall treatments are made to the upper 3 to 5 feet of the water body, 

whereas drinking water intakes are typically located at the deepest point in 

municipal reservoirs where endothall concentrations would be expected to 

be lower. 

10
• Monitoring data for endothall suggest the average concentrations of 

endothall in drinking water are well below the modeled estimates. 

Monitoring data for finished water are available from the National 

Contaminant Occurrence Database (NCOD) for both surface and ground 

water. Detectable residues of endothall were found in only 7 of 27,494 or 

0.025% of ground water samples and 8 of 5,112 or 0.15% of surface water 

samples. 

The maximum detected concentrations in ground and surface water 

were 4,550 ppb and 2,900 ppb, respectively; and the mean concentration 

for samples with detectable residues was 670 ppb in ground water and 865 

ppb in surface water. Although these few values are well above the 

established Maximum Contaminant Level (MCL) for endothall of 100 

ppb, greater than 99% of ground and surface water samples contained 

concentrations below the limit of detections (10 ppb). Endothall may be 

applied to water at concentrations up to 5000 ppb. These high values 

would not be representative of average concentrations in drinking water. 

This determination is further supported by additional monitoring data 

collected under the Safe Drinking Water Act (SDWA). Data collected 

under the Safe Drinking Water Information System (SDWIS) between 

1993 and 2005 indicated only 2 occurrences of endothall residues that 

exceeded the established MCL of 100 ppb. Both of these occurred in 

1994, with no violations occurring since that time. In addition, historical 

data analysis of compliance and occurrence data from treated water 

systems has shown detections of very lo w frequency to be outliers relative 

to whole datasets. Given the low frequency of detection and the more than 

an order of magnitude difference between the more than 27,000 samples 

below the detection limit and 8 detects above, the observed detects would 

appear to be statistical outliers. 

For these reasons, EPA does not believe the modeled estimated concentrations are 

appropriate for use in estimating exposure to endothall in drinking water. As noted 

above, an MCL of 100 ppb has been established for endothall. The MCL is based on a 

chronic feeding study which established a NOEL of 2 mg/kg/day based on increased 

absolute relative weights of the stomach and small intestine. Although the MCL is likely 

to overestimate average (i.e., chronic) residues of endothall in drinking water, EPA 

believes it provides a reasonable high-end estimate of potential drinking water 

concentrations from the aquatic uses of endothall. Consequently, the MCL of 100 ppb 

was used in the dietary risk assessment. 

11
b. Terrestrial Uses 

Surface water concentrations from use on terrestrial crops were estimated using 

the Tier II model PRZM (version 3.12)/EXAMS (version 2.98.04) and ground water 

concentrations were estimated using the Tier I model of SCIGROW (version 2.2). A 

total of five scenarios were modeled for endothall use on terrestrial crops based on 

Agency standard scenarios. The scenarios modeled were cotton and alfalfa in California, 

Oregon hops, and potatoes in Maine and Idaho. These scenarios were chosen to estimate 

the concentration of endothall in surface drinking water over a geographically dispersed 

range of existing terrestrial crop production areas. These scenarios chosen for this 

assessment represent all relevant PRZM/EXAMS scenarios for the terrestrial use of 

endothall. Endothall may be applied by aerial or ground equipment as per the labels of 

this product. All terrestrial scenarios were modeled with aerial application equipment, 

which results in the highest amount of spray drift, except for hops, which is treated by 

ground equipment. 

The estimated peak surface water concentration of endothall as a result of 

terrestrial use is 7.1 ppb. The estimated chronic (non-cancer) surface water concentration 

of endothall as a result of terrestrial use is 2.5 ppb. Modeled groundwater concentrations 

of endothall, both peak and chronic, are not expected to exceed 0.086 ppb. 

5. Chronic Risk from Food Plus Drinking Water

To assess chronic risk from food plus drinking water, exposure estimates from 

both chronic dietary (both directly treated and irrigated crops) and chronic drinking water 

were combined in the DEEMTM modeling program. Estimated concentrations of 

endothall were modeled by the Agency as discussed above. Based on the rationale 

described above, the Agency assumed an endothall concentration of 100 ppb as the 

average concentration in drinking water. This concentration is the MCL for endothall. 

Because the Agency feels that modeled concentrations are not appropriate for use in 

estimating exposure to endothall in drinking water, the MCL of 100 ppb was used. 

Chronic dietary risks (food and drinking water) do not exceed the Agency's level 

of concern, although drinking water risk for infants less than one year old is at the level 

of concern. As previously discussed, the Agency believes that this risk estimate is the 

result of conservative assumptions. 

Table 4. Summary of Dietary Exposure and Risk from Directly Treated Crops, 

Irrigated Crops, and Drinking Water 

Population Subgroup Dietary Exposure 

mg/kg/day 

% cPAD 

(Food + Water) 

General U.S. Population 0.002297 33 

All Infants (<1 year old) 0.007234 103 

Children 1- 2 years old 0.003574 51 

12
6. Residential Risk 

Endothall products may be used in residential settings to control aquatic weeds 

and algae in ponds and garden pools. Therefore, homeowners may potentially be 

exposed to endothall by applying home-use formulations. In addition, there is also a 

potential for exposure to adults and children from incidental oral and dermal exposure 

during recreational activities in public waters treated with endothall. As a result, risk 

assessments were completed for both residential handlers and post-application scenarios. 

Residential risks are measured by a margin of exposure (MOE), which determines how 

close the exposure comes to a No Observed Adverse Effect Level (NOAEL) taken from 

animal studies. For residential risk from endothall, Margins of Exposure (MOEs) that are 

greater than or equal to 100 are below EPA’s level of concern for short-term residential 

exposures. 

Residential applications are only expected to occur over short-periods of time. 

Therefore, intermediate-term and long-term residential exposure assessments were not 

conducted. The anticipated use patterns that could potentially lead to residential handler 

exposure are: (1) loading/applying granular formulations with a belly grinder; and (2) 

applying granular formulations by hand. 

The exposure pathway of concern for residential handlers is short-term inhalation. 

The short-term inhalation NOAEL is 9.4 mg/kg/day based on decreased pup body weight. 

This endpoint is taken from the two-generation rat reproduction study. Short-term 

inhalation MOEs for loading/applying granular formulations with a belly grinder range 

from 190 to 830. For handlers applying granular formulations by hand, the short-term 

inhalation MOE is 2700. Therefore, residential hand ler risks are below the Agency's level 

of concern. 

For residential post-application exposures, exposures on the day of application 

after an application to a public water body are of the greatest concern. The Agency 

identified incidental oral exposure (from swallowing water while swimming) and the 

potential for dermal irritation while swimming as possible post-application exposure 

scenarios. The Agency conducted an assessment, using the SWIM modeling program, to 

assess incidental exposures. Risks were calculated using MOEs, where an MOE greater 

than or equal to 100 is below EPA’s level of concern. The incidental oral endpoint for 

short-term exposure of 9.4 mg/kg/day was selected from a two-generation rat 

reproduction study (in which lesions in the gastric epithelium were observed). MOEs 

calculated for both children (ages 6-10) and adults are below the Agency's level of 

concern for incidental oral (280 and 900, respectively). The expected exposure to 

swimmers from the dermal route would be extremely low (the highest application rate 

results in a water concentration of 5 ppm) and would not likely result in any irritation to 

the skin. Currently, several Special Local Needs (SLN) labels have swimming 

restrictions that prohibit access to waters following commercial applications. 

13
7. Aggregate Risk

(For a complete discussion, see Section 7.0 of the Endothall: HED Chapter of the 

Reregistration Eligibility Decision Document, Corrected Following Public Comments, 

dated September 30, 2005.) 

Aggregate exposure to a pesticide combines exposure from food, drinking water, 

and, if applicable, residential exposure. For endothall, aggregate risk was measured as a 

margin of exposure. MOEs for short-term residential exposures above or equal to the 

target level (100) are not of concern to the Agency. In the case of endothall, residential 

exposures are only expected to be episodic, or short-term. Therefore, intermediate-term 

and long-term residential exposures were not assessed. 

For adult short-term aggregate exposure, EPA aggregated inhalation exposure 

during residential applications, oral exposure during swimming, and dietary exposure 

from food and drinking water. For children (ages 6-10), EPA considered incidental oral 

exposure during swimming and dietary exposure (food and drinking water). Although 

infants are the most sensitive subgroup for chronic dietary concerns, the Agency did not 

find it appropriate to assume infants (less than one year old) participate in swimming 

activities in outdoor water bodies such as lakes and ponds. The MOEs calculated are 

above the target MOE, with values of 250 for children (ages 6-10) and 310 for adults (age 

50 years and older). Therefore, short-term aggregate risks are below the Agenc y's level 

of concern. 

Because EPA does not expect chronic residential exposure, chronic aggregate 

risks are equal to chronic dietary risks (food plus water). As described above in Section 

5, these risks are at the Agency’s level of concern. 

8. Occupational Risk 

(For a complete discussion, see the Revised Occupational and Residential Exposure 

Assessment and Recommendations for the Reregistration Eligibility Decision Document 

for Endothall, dated August 12, 2005). 

Workers can be exposed to a pesticide while mixing, loading, or applying a 

pesticide, and when entering a treated site. Handler and worker risks are measured by a 

margin of exposure (MOE), which determines how close the occupational exposure 

comes to a No Observed Adverse Effect Level (NOAEL) taken from animal studies. The 

Agency initially calculates the handler risks using the least protective measures. This is 

called the baseline assessment, and assumes an individual’s normal work clothing (e.g., 

long sleeve shirt and long pants), no gloves, and no respirator. If there is a concern at this 

level, the Agency considers the use of protective measures (e.g., personal protective 

equipment and engineering controls) to lower the risk. Personal protective equipment 

(PPE) can include an additional layer of clothing, chemical-resistant gloves, and a 

respirator. Common examples of engineering controls include: enclosed tractor cabs, 

closed loading systems, and water-soluble packaging. 

14
a. Occupational Handler Summary 

The Agency has determined that workers may be exposed to endothall while 

mixing, loading, applying, and flagging for aerial applications. In the absence of 

chemical-specific monitoring data for endothall, exposure analyses were performed using 

the Pesticide Handlers Exposure Database (PHED). The MOEs for occupational 

exposures were calculated for short-term and intermediate-term inhalation exposures for 

terrestrial, aquatic, and cooling tower applications. For the short-term inhalation 

exposure scenario the NOAEL is 9.4 mg/kg/day. This endpoint is based on decreased 

pup body weight. For the intermediate-term inhalation exposure scenario the LOAEL is 

2 mg/kg/day based on proliferative lesions of the gastric epithelium. Both endpoints for 

the inhalation exposure scenarios are taken from the two-generation oral rat reproduction 

study. Toxicity from dermal exposures was not assessed because a dermal endpoint was 

not established for systemic effects. End-use product labels will address protection for 

workers regarding dermal exposure. For occupational risks, short-term MOEs that are 

greater than 100 and intermediate-term MOEs that are greater than 300 do not exceed the 

Agency’s level of concern. The level of concern for short and intermediate-term 

exposures are based on 10X to account for interspecies extrapolation to humans from 

animal test species and 10X to account for intraspecies sensitivity. For intermediate-term 

exposures, an additional 3X is applied to account for the lack of a NOAEL. 

i. Terrestrial Applications

All risks calculated for short-term inhalation exposure to mixers, loaders, and 

applicators are below the Agency's level of concern (MOEs range from 390 to 38,000) 

when wearing baseline attire. For intermediate-term inhalation exposure to mixers, 

loaders, and applicators, all risks are below the Agency's level of concern (MOEs range 

from 500 to 8,100 with baseline attire) with the exception of mixing and loading liquids 

for aerial applications (MOEs range from 83-290 with baseline attire). 

ii. Aquatic Applications

In the absence of specific occupational exposure data for aquatic use scenarios, 

surrogate exposure scenarios were used to assess certain occupational scenarios. To 

assess exposure from mixing, loading, and applying liquid formulations for applications 

using boat-mounted spray equipment, the exposure scenario for mixing and loading 

liquids for ground boom equipment was used. To assess exposure from mixing and 

loading concentrate to direct metering/subsurface application equipment, the mixing and 

loading scenario for mixing and loading liquid formulations was used. To assess 

exposure from mixing, loading, and applying concentrate liquid formulations with a 

handgun sprayer, the lawn care operator (LCO) exposure information from the Outdoor 

Residential Exposure Task Force (ORETF) was used. Finally, to assess exposure from 

loading and applying granular formulations, the open loading granular application 

15
scenario was used from the Pesticide Handler Exposure Database (PHED). For aquatic 

exposures, MOEs were calculated using an 80% (PF5) respirator. Current labels require 

workers to wear this type of protection. 

All risks for short-term exposures from mixing, loading, and applying liquid 

formulations are below the Agency's level of concern when workers wear an 80% (PF5) 

respirator (NIOSH TC-21C) (MOEs range from 1150 to 130,000). All risks for 

intermediate-term exposures from mixing, loading, and applying liquid formulations are 

below the Agency's level of concern when workers wear an 80% (PF5) respirator 

(NIOSH TC-21C) (MOEs range from 400 to 275,000) with the exception of mixing and 

loading liquids for ground-spray type applications at high rates (MOE = 250). However, 

although the MOE for this scenario does not reach the target of 300, it is unlikely that 

typical applications will result in a risk to workers. For example, as part of this RED, the 

Agency is requiring aquatic labels to specify that applications at the highest rate are for 

spot treatments only. The exposure assessment for mixing and loading liquids assumed a 

treatment area of 30 acres. In addition, intermediate-term exposure assessments assume 

more than 30 days of exposure. It is unlikely that applications to large areas at high rates 

will be conducted for that length of time. As a result of these assumptions and the 

mitigation measures set forth in this RED, the Agency believes that the 80% respirator 

will adequately protect workers for the above scenarios. 

All risks for short-term exposures from loading and applying granular 

formulations are below the Agency's level of concern (MOEs range from 208 to 860 with 

baseline attire). For intermediate-term exposure from loading and applying granular 

formulations, risks are of concern to the Agency (MOEs range from 220-240 with an 

80% (PF5) respirator). 

iii. Cooling Tower (Biocide) Applications 

Occupational exposures were assessed for applications of endothall to cooling 

towers to control mollusks and algae. Labels indicate that endothall should be 

continuously fed into cooling tower waters for 6 to 144 hours. Although a continuous 

feed is a daily operation, handlers treating water systems are expected to apply endothall 

on a limited basis and are best represented by short-term exposure duration. All shortterm inhalatio n risks for cooling tower uses are below the Agency's level of concern 

(MOEs range from 620 to 260,000). 

b. Post-application Occupational Risk 

The Agency did not assess occupational post-application risks to agricultural 

workers following treatments to agricultural crops, because no systemic dermal endpoint 

of concern was established. Based on acute toxicity of the active ingredient and potential 

to cause severe dermal irritation, endothall is classified as a severe dermal irritant. 

However, a re-entry interval of 48 hours is required for agricultural workers. Postapplication occupational exposures following endothall applications to aquatic areas is 

16
likely limited to persons who contact the treated water to perform tests, or persons such 

as agricultural workers who may contact treated water in irrigation canals. 

9. Human Incident Summary

To assess occupational and non-occupation incidents, the Agency consults several 

incident reporting databases. These include: the Office of Pesticide Program Incident 

Data System, Poison Control Centers, California Department of Pesticide Regulation, 

National Pesticide Telecommunications Network, and the National Institute of 

Occupational Safety and Health's Sentinel Event Notification System for Occupational 

Risks. 

Relatively few incidents of illness have been reported due to endothall. In general 

reports are of irritative effects to the eye and skin. No endothall related hospitalizations 

have been reported due to pesticide use. No recommendations are made based on the 

very limited incident data available for endothall. 

B. Ecological Risk

To estimate potent ial ecological risk, EPA integrates the results of exposure and 

ecotoxicity studies using the risk quotient method. Risk quotients (RQs) are a screening 

level for potential risk and are calculated by dividing exposure estimates by ecotoxicity 

values, both acute and chronic, for various wildlife species. RQs are then compared to 

levels of concern (LOCs). Table 5 lists levels of concern used in the risk assessment. 

Generally, the higher the RQ, the greater the potential risk. Risk characterization 

provides further information on the likelihood of adverse effects occurring by considering 

the fate of the chemical in the environment, communities and species potentially at risk, 

their spatial and temporal distributions, and the nature of the effects observed in studies. 

RQ values are provided in parentheses for indicated exceedances in the summary below. 

Table 5. Levels of Concern for Ecological Risk 

If RQ > LOC value given below... Then EPA presumes... 

Terrestrial Aquatic Plants Risk Presumption 

Organisms Organisms 

0.5 0.5 1 Acute Risk- there is potential for acute risk; regulatory action 

may be warranted in addition to restricted use classification 

0.2 0.1 N/A Acute Restricted Use- there is potential for acute risk, but may 

be mitigated through restricted us e classification 

0.1 0.05 1 Acute Endangered Species - endangered species may be 

adversely affected; regulatory action may be warranted 

1 1 N/A Chronic Risk-there is potential for chronic risk; regulatory action 

may be warranted 

1. Environmental Fate and Transport 

17 
(For a complete discussion, see the Environmental Fate and Ecological Risk Assessment 

of Endothall-Revised, dated April 22, 2005.) 

The endothall environmental risk assessment includes an assessment of risks to 

aquatic organisms from both the aquatic and terrestrial uses. Endothall is applied as 

either endothall dipotassium salt or endothall N,N-dimethylalkylamine salt. After 

application of either the dipotassium salt or N,N-dimethylalkylamine salt, endothall acid 

is formed by degradation. The acid is the form of endothall that acts as an herbicide, 

desiccant, algaecide, and biocide. The three forms of endothall have dissimilar toxicity 

properties, with the endothall N,N-dimethylalkylamine salt being more toxic to aquatic 

animals than the dipotassium salt. However, the dipotassium salt and endothall acid have 

similar toxicity properties. 

The dissociation constants of both of the endothall salts indicate that at most 

environmental pH levels, the endothall salt, endothall acid, and the corresponding cation 

(potassium or coco-alkylamine) will be present. After aquatic applications, endothall 

salts, acid, and cation components will be found mainly in the water column. The 

potassium io ns that dissociate from the dipotassium salt are not of concern as a source for 

additional toxicity. The persistence of endothall acid in aqueous environments is 

expected to be less than ten days. In terrestrial environments, endothall acid degrades 

with a half-life of approximately ten days. The half-lives of the endothall N,Ndimethylalkylamine salt and the coco-amine have not been provided. 

The environmental risk assessment is organized by risks posed by each form of 

endothall. Therefore, the following sections are also organized in that manner. 

2. Terrestrial Organism Risk

(For a complete discussion, see the Environmental Fate and Ecological Risk Assessment 

of Endothall-Revised, dated April 22, 2005.) 

a. Risks from Use of Endothall N, N-dimethylalkylamine Salt 

The N,N-dimethylalkylamine salt form of endothall is the only form used 

terrestrially. In terrestrial scenarios, in addition to the presence of N,Ndimethylalkylamine salt, it is possible that the degradation products (endothall acid and 

coco-alkylamine cation) will be present. As a result of exposure to these compounds 

several groups of organisms are potentially at risk. Acute mammalian LOCs are 

exceeded from use on all terrestrial sites (RQs range from 0.12 to 9.74). Based on 

endothall acid chronic toxicity, birds feeding on grasses, broad leaf plants, and small 

insects are potentially at risk from the use of N, N-dimethylalkylamine salt on potatoes, 

hops, alfalfa, and clover (RQs range from 1.02 to 9.10). Chronic RQs for birds are based 

on early embryonic mortality. From use on alfalfa, clover, potatoes, and hops chronic 

LOCs for mammals are exceeded (RQs range from 1.04 to 3.03). Chronic RQs for 

mammals are based on decreased pup body weight and death of animal within one day. 

18
Because endothall is a herbicide, non-target plants are potentially at risk from 

drift and runoff of endothall N,N-dimethylalkylamine salt away from target use sites. 

LOCs are exceeded for non-target plants caused by adjacent runoff and wetland area 

runoff from applications made to potatoes, hops, alfalfa, clover, and cotton (RQs range 

from 2.3 to 27.5). LOCs for acute algae toxicity are also exceeded for terrestrial use of 

N, N-dimethylalkylamine salt (RQs range from 1 to 7.65). 

The Agency feels that potential risks to terrestrial organisms from the N, Ndimethylalkylamine salt may have been underestimated because terrestrial RQs were 

based on toxicity data using endothall acid and endothall dipotassium salt. Available 

ecotoxicity studies using the N, N-dimethyalkylamine salt indicate it is more toxic to 

organisms than dipotassium salt or endothall acid. Additional data pertaining to the fate 

and ecotoxicity of the N, N-dimethylalkylamine salt is being requested. 

3. Aquatic Organism Risk

The RQs presented below are representative of RQs resulting from a range of 

application rates for aquatic use. The rates that were used in the assessment included 0.5, 

1.0, 2.5, 3, 4, and 5 ppm. A range of application rates was used in order to compare RQs 

at low, average, and maximum application rates. 

Although the assessment was performed using very high end label rates, typical 

rates used to control algae and plants are low, 0.05-0.3 ppm and 1-3 ppm, respectively. 

Therefore, RQs calculated at rates above 3 ppm are conservative expressions of risk and 

represent exposure scenarios that are infrequent. 

a. Risks from Use of Endothall N, N-dimethylalkylamine Salt 

The N,N-dimethylalkylamine salt form of endothall is more toxic than other 

forms of endothall (2 to 3 orders of magnitude) to aquatic organisms, both on an acute 

and chronic basis. On an acute basis, the N,N-dimethylalkylamine salt is considered to 

be highly toxic to very highly toxic to freshwater fish, moderately toxic to highly toxic to 

estuarine/marine fish, and moderately toxic to very highly toxic to estuarine/marine 

invertebrates. Acute LOCs are exceeded for freshwater and marine fish (RQs range from 

0.6 to 119), invertebrates (RQs range from 3 to 417), vascular plants (RQs range from 2 

to 7), and algae (RQs range from 217 to 2174) from all direct applications to water, 

including once-through cooling tower uses. Chronic LOCs are exceeded for freshwater 

fish (RQs range from 2.2 to 22.2) and invertebrates (RQs range from 133 to 1331.3) from 

all direct applications to water, including once-through cooling tower uses. For 

freshwater fish, chronic RQs are based on survival, and for freshwater invertebrates, 

chronic RQs are based on reproduction rate. 

The Environmental Incident Information System (EIIS) database has records of 

two fish kills related to the use of endothall N, N-dimethylalkylamine salt. Accidental 

19
misuse of the biocide formulation in a Minnesota power plant cooling chamber resulted 

in the deaths of thousands of green sunfish, catfish, and shiners due to the high water 

temperature (92° C) at application. The second incident occurred when a 5-gallon can of 

endothall N, N-dimethylalkylamine salt product spilled into a drain in California and 

resulted in the death of over one thousand carp. 

Terrestrial use of N,N-dimethylalkylamine salt also poses risks to aquatic 

organisms from runoff and drift. Acute LOCs are exceeded for freshwater fish (RQs 

range from 0.5 to 0.92), freshwater invertebrates (RQs range from 0.5 to 3.23), and algae 

(RQs range from 1.04 to 7.65) from runoff. 

b. Risks from Use of Endothall Dipotassium Salt

Endothall dipotassium salt is applied directly to the aquatic environment. 

The Agency used the acute toxicity values for endothall dipotassium salt to calculate risk 

to fish and aquatic invertebrates. On an acute basis, the dipotassium salt is considered to 

be slightly toxic to practically non-toxic to freshwater fish, slightly toxic to 

estuarine/marine fish, and moderately toxic to practically non-toxic to estuarine/marine 

invertebrates. Aquatic non-endangered vascular plant LOCs are exceeded for acute 

exposure from all direct applications to water (RQs range from 2.5 to 8). Acute LOCs 

are exceeded for freshwater fish at maximum application rates (RQ = 0.55). Chronic risk 

was calculated for aquatic animals using endothall acid and endothall dipotassium salt 

toxicity data due to the dissociation of the dipotassium salt to endothall acid. Chronic 

LOCs are minimally exceeded for freshwater fish from the highest application rate (RQ 

=1) and for freshwater invertebrates from the two highest application rates (RQs range 

from 1.1 to 1.4). Chronic RQs for freshwater fish are based on wet weight and length, 

and chronic RQs for freshwater invertebrates are based on length and number of 

offspring. 

c. Risks from Endothall Acid

Although endothall acid is not directly applied to use sites, it is possible that 

plants and animals may be exposed to the acid. The dissociation constants of both of the 

salts indicate that at most environmental pH levels, the endothall salt, endothall acid, and 

the corresponding cation (potassium or coco-alk ylamine) will all be present. Endothall 

acid is considered to be slightly toxic to freshwater fish, slightly toxic to practically nontoxic to aquatic freshwater invertebrates, practically non-toxic to estuarine/marine fish, 

and slightly toxic to estuarine/marine invertebrates on an acute basis. Chronic LOCs are 

minimally exceeded for freshwater fish from applications at the highest rate (RQ = 1), 

and for freshwater invertebrates from the two highest application rates (RQs range from 

1.1 to 1.4). Chronic RQs for freshwater fish are based on wet weight and length, and 

chronic RQs for freshwater invertebrates are based on length and number of offspring. 

20
4. Risk to Endangered Species

a. Risks from Use of Endothall N, N-dimethylalkylamine Salt 

As discussed previously, endothall N,N-dimethylalkylamine salt is used in both 

aquatic and terrestrial environments. For this reason, aquatic organisms are susceptible to 

exposure from aquatic applications, and both terrestrial and aquatic organisms are 

susceptible to exposure from terrestrial applications. Acute threatened and endangered 

species LOCs are exceeded in the screening level risk assessment for freshwater fish 

(RQs range from 12 to 119), estuarine/marine fish (RQs range from .6 to 6.10), 

freshwater invertebrates (RQs range from 6 to 417), estuarine/marine invertebrates (RQs 

range from 3.10 to 31.10), freshwater endangered vascular plants (RQs range from 3 to 

33), and freshwater algae (RQs range from 217 to 2174) from all direct applications to 

water, including once-through cooling tower uses. Chronic threatened and endangered 

LOCs are exceeded for freshwater fish (RQs range from 2.2 to 22.2) and invertebrates 

(RQs range from 133 to 1331.3) from all direct applications to water, including oncethrough cooling tower uses. 

From applications of endothall N, N-dimethylalkylamine salt made to terrestrial 

environments, both aquatic and terrestrial organisms are potentially exposed. Acute 

threatened and endangered LOCs are exceeded in the screening level risk assessment for 

freshwater fish (RQs range from 0.06 to 0.92), estuarine/marine fish (RQs =0.05), 

freshwater invertebrates (RQs range from 0.05 to 3.23) and marine/estuarine 

invertebrates (RQs range from 0.05 to 0.24), and algae (RQs range from 1.04 to 7.65) 

from runoff. Acute threatened and endangered mammalian LOCs are also exceeded in 

the screening level risk assessment for all terrestrial uses (based on endothall acid toxicity 

values) (RQs range from 0.10 to 9.74). Chronic threatened and endangered species LOCs 

are exceeded in the screening level risk assessment for mammals (RQs range from 1.04 

to 3.03) and birds (RQs range from 1.02 to 9.10) from use on potatoes, hops, alfalfa, and 

clover. 

Threatened and endangered plants are potentially exposed to N, Ndimethylalkylamine salt from drift and runoff from targeted application sites. Threatened 

and endangered species LOCs for non-target vascular plants are exceeded in the 

screening level risk assessment from adjacent runoff, wetland area runoff, and spray drift 

associated with use on all crops (RQs range from 1.5 to 137.5). 

Further, there may be potential for indirect effects to listed species in any taxa that 

are dependent upon a taxa that may experience effects from the use of this pesticide. 

The Agency feels that potential risks to terrestrial organisms from the N, Ndimethylalkylamine salt may have been underestimated because RQs were based on 

toxicity data using endothall acid and endothall dipotassium salt. Available ecotoxicity 

studies using the N, N-dimethyalkylamine salt indicate it is more toxic to organisms than 

21
dipotassium salt or endothall acid. Additional data pertaining to the fate and ecotoxicity 

of the N, N-dimethylalkylamine salt is being requested. 

Risks to endangered species identified in the Environmental Fate and Ecological 

Risk Assessment for Endothall are based solely on EPA's screening level assessment and 

do not constitute "may effect" findings under the Endangered Species Act. 

b. Risks from Use of Endothall Dipotassium Salt

Several threatened and endangered species level of concern exceedences in the 

screening level risk assessment occur from use of endothall dipotassium salt. 

Exceedences occur for acute effects to freshwater fish (RQs range from 0.05 to 0.55) and 

vascular plants (RQs range from 181 to 1087) from all direct applications to water. From 

applications at the highest rates (4 and 5 ppm), exceedences occur for marine/estuarine 

fish (RQs range from 0.05 to 0.06), freshwater invertebrates (RQs range from 0.06 to 

0.08), and marine/estuarine invertebrates (RQs range from 0.06 to 0.07). Chronic RQs 

are minimally exceeded for freshwater fish (RQ = 1) and freshwater invertebrates (RQs 

range from 1.1 - 1.4) at maximum application rates. Data are unavailable with which to 

assess potential chronic risks to estuarine/marine species and therefore, potential risks can 

not be dismissed for these taxa. Further, there may be potential for indirect effects to 

listed species in any taxa that are dependent upon a taxa that may experience effects from 

the use of this pesticide. These findings are based solely on EPA’s screening level 

assessment and do not constitute “may affect” findings under the Endangered Species 

Act. 

IV. Risk Management, Reregistration, and Tolerance Reassessment Decision

A. Determination or Reregistration Eligibility

Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission 

of relevant data concerning an active ingredient, whether or not products containing the 

active ingredient are eligible for reregistration. The Agency has previously identified and 

required the submission of the generic (i.e., active ingredient-specific) data required to 

support reregistration of products containing endothall as an active ingredient. The 

Agency has completed its review of these generic data, and has determined that the data 

are sufficient to support reregistration of all supported products containing endothall. 

The Agency has completed its assessment of the dietary, occupational, drinking 

water, and ecological risks associated with the use of pesticide products containing the 

active ingredient endothall. Based on a review of these data and on public comments on 

the Agency's assessments for the active ingredient endothall, the Agency has sufficient 

information on the human health and ecological effects of endothall to make decisions as 

part of the tolerance reassessment process under FFDCA and reregistration process under 

FIFRA, as amended by FQPA. The Agency has determined that endothall containing 

products are eligible for reregistration provided that (i) current data gaps and 

22
confirmatory data needs are addressed; (ii) the risk mitigation measures outlined in this 

document are adopted; and (iii) label amendments are made to reflect these measures. 

Label changes are summarized in Section V. Appendix A summarizes the uses of 

endothall that are eligible for reregistration. Appendix B identifies generic data 

requirements that the Agency reviewed as part of its determination of reregistration 

eligibility of endothall, and lists the submitted studies the Agency found acceptable. Data 

gaps are identified as generic data requirements that have not been satisfied with 

acceptable data or data which are needed to confirm the decision presented here. 

Based on its evaluation of endothall, the Agency has determined that endothall 

products, unless labeled and used as specified in this document, would present risks 

inconsistent with FIFRA. Accordingly, should a registrant fail to implement any of the 

risk mitigation measures identified in this document, the Agency may take regulatory 

action to address the risk concerns from the use of endothall. If all changes outlined in 

this document are incorporated into the product labels, then all current risks for endothall 

will be adequately mitigated for the purposes of this determination under FIFRA. 

Additionally, once an endangered species assessment is completed, further changes to 

these registrations may be necessary as explained in section IV.D.5.a of this document. 

B. Public Comments and Responses

Through the Agency's public participation process, EPA worked with 

stakeholders and the public to reach the regulatory decisions for endothall. During the 

public comment period on the risk assessments, which closed on July 11, 2005, the 

Agency received comments from the registrant, the United States Army Corps of 

Engineers, endothall applicators, and concerned citizens. These comments in their 

entirety are available in the public docket, http://docket.epa.gov/edkpub/index.jsp, OPP2005-0370. The Agency's responses to these comments are incorporated into the revised 

chapters and are available in the public docket. 

C. Regulatory Position

1. Food Quality Protection Act Findings

a. "Risk Cup" Determination

As part of the FQPA tolerance reassessment process, EPA assessed the risks 

associated with endothall. The Agency has concluded that tolerances for endothall meet 

the FQPA safety standards and that the aggregate (food, drinking water, and residential 

sources) exposure is within the "risk cup". The Agency has determined that the human 

health risks from these combined exposures are within acceptable levels. In reaching this 

determination, EPA has considered the available information on the special sensitivity of 

infants and children. 

23
b. Determination of Safety to U.S. Population (Including 

Infants and Children) 

The Agency has determined that the established tolerances for endothall, with 

amendments and changes as specified in this document, meet the safety standards under 

the FQPA amendments to section 408(b) (2) (D) and 408(b) (2) (c) of the FFDCA, and 

that there is a reasonable certainty that no harm will result to infants, children, or the 

general population or any subgroup from the use of endothall. The safety determination 

for infants and children considers factors including toxicity, use practices, and 

environmental behavior noted above for the general population, but also takes into 

account the possibility of increased dietary exposure due to specific consumption patterns 

of infants and children, as well as the possibility of increased susceptibility to the toxic 

effects of endothall residues in this population subgroup. 

No special FQPA Safety Factor is necessary to protect the safety of infants and 

children. In determining whether or not infants and children are particularly susceptible 

to toxic effects from endothall residues, the Agency considered the completeness of the 

database for developmental and reproductive effects, the nature of the effects observed, 

and other information. The FQPA safety factor has been removed (i.e., reduced to 1X) 

for endothall based on: (1) there was no quantitative or qualitative evidence of increased 

susceptibility following prenatal exposure to rats in the developmental toxicity study or 

pre/postnatal exposure to rats in the 2-generation rat toxicity study, (2) there are no 

concerns for residual uncertainty for prenatal toxicity in the available developmental 

study, or the 2-generation rat toxicity study, and (3) there are no residual uncertainties for 

exposure. 

c. Endocrine Disruptor Effects 

EPA is required under the FFDCA, as amended by FQPA, to develop a screening 

program to determine whether certain substances (including all pesticide active and other 

ingredients) "may have an effect in humans that is similar to an effect produced by a 

naturally occurring estrogen, or other endocrine effects as the Administrator may 

designate." Following recommendations of its Endocrine Disruptor Screening and 

Testing Advisory Committee (EDSTAC), EPA determined that there was a scientific 

basis for including, as part of the program, the androgen and thyroid hormone systems, in 

addition to the estrogen hormone system. EPA also adopted EDSTAC's recommendation 

that EPA include evaluations of potential effects in wildlife. For pesticides, EPA will use 

FIFRA and, to the extent that effects in wildlife may help determine whether a substance 

may have an effect in humans, FFDCA authority to require the wildlife evaluations. As 

the science develops and resources allow, screening for additional hormone systems may 

be added to the Endocrine Disruptor Screening Program (EDSP). 

When the appropriate screening and/or testing protocols being considered under 

the EDSP have been developed, endothall may be subject to additional screening and/or 

testing to better characterize effects related to endocrine disruption. 

24
d. Cumulative Risks

Risks summarized in this document are those that result only from the use of 

endothall. The Food Quality Protection Act (FQPA) requires that the Agency consider 

"available information" concerning the cumulative effects of a particular pesticide's 

residues and "other substances that have a common mechanism of toxicity". The reason 

for consideration of other substances is due to the possibility that low-level exposures to 

multiple chemicals substances that cause a common toxic effect by a common toxic 

mechanism could lead to the same adverse health effect as would a higher level of 

exposure to any of the substances individually. Unlike other pesticides for which EPA 

has followed a cumulative approach based on a common mechanism of toxicity, EPA has 

not made a common mechanism of toxicity finding for endothall. 

 For information regarding EPA's efforts to determine which chemicals have a 

common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, 

see the policy statements released by EPA's Office of Pesticide Programs concerning 

common mechanism determinations and procedures for cumulating effects from 

substances found to have a common mechanism on EPA's website at 

http://www.epa.gov/pesticides/cumulative. 

2. Tolerance Summary

A tolerance summary is presented belo w in Table 3. The Agency has determined 

that the residue of concern in plants, livestock, and fish is endothall and its monomethyl 

ester. The residue to be measured for tolerance enforcement is the combined residues of 

endothall and its monomethyl ester. 

Tolerances for residues of endothall, from use of the mono-N,Ndimethyalkylamine salt, in/on plant commodities should be revised to be expressed in 

terms of endothall per se and its monomethyl ester [40 CFR § 180.293]. Tolerances that 

are currently established for residues in/ on undelinted cotton seed, hops, potato, and rice 

grain and straw will not change in value. An interim tolerance was established for 

residues of endothall in potable water; this tolerance will be proposed for revocation (an 

MCL is in effect for 100 μg/L). Under 40 CFR § 180.319 an interim tolerance exists for 

residues of endothall in/on sugar beets; this tolerance should be made permanent once 

additional data has been received and deemed acceptable. No tolerances have been 

established for livestock commodities. The available ruminant and poultry metabolism 

studies suggest that detectable residues of endothall are likely to be transferred to meat, 

milk, poultry and eggs as a result of registered uses on feedstuffs. The registrant has been 

required to conduct animal (ruminant and poultry) feeding studies in meat, milk, poultry, 

and eggs in order to set appropriate tolerances. Data have been submitted to support 

tolerances in finfish, catfish, and shellfish. This action is not incorporated into this 

document and will be addressed in a separate action. 

25
A gas chromatography method with microcoulometric nitrogen detection is listed 

as Method I in the Pesticide Analytical Manual (PAM, Volume II) for the determination 

of endothall residues in/on crop commodities. An improved high performance liquid 

chromotography-mass selective detector (HPLC-MSD) method has been submitted as a 

confirmatory enforcement method for plants and fish. Data collection and regulatory 

analytical methods for animal commodities are currently not available and are required 

for reregistration. 

The submitted magnitude of the residue studies for alfalfa seed, cottonseed, and 

potatoes have been reviewed and were deemed inadequate to satisfy reregistration 

requirements. The submitted data for hops supports the national Section 3 labels, but 

does not support the Section 24(c) Special Local Need uses because a different preharvest interval was used. The submitted residue data for irrigated cabbage, celery, 

grapefruit, pepper, and turnip have been deemed inadequate because the water treatment 

rate was less than the maximum label rate. The submitted confined rotational crop study 

was deemed inadequate because the test substance was applied at a rate less than the 

maximum registered seasonal rate for crops which can be rotated. 

The submitted processing studies on cotton and potatoes are acceptable, and the 

results of these studies show that endothall does not concentrate in the processed 

fractions of cotton and potatoes. A sugar beet processing study was submitted and was 

deemed inadequate. 

Although additional data are required to confirm the existing tolerance level in/on 

the following commodities, the Agency has no dietary, drinking water or residential risk 

concerns associated with these tolerances and considers them reassessed: cotton 

(undelinted seed), hop, potato, rice (grain), rice (straw), and sugar beet. 

Endothall is registered for use on aquatic areas such as irrigation and drainage 

canals, and the treated water from these sites may be diverted to irrigate food or feed 

crops. The Agency requested the registrant to submit studies to address residues on 

irrigated crops. In response, the registrant submitted limited studies that investigated the 

magnitude of endothall residues on irrigated crops such as cabbage, celery, grapefruit, 

peppers, and turnips. These studies were not conducted using maximum labeled 

application rates or label-specified application intervals. Additional data on irrigated 

crops are required for reregistration. For the purpose of continuity, the Agency is 

requiring that the submitted studies be redone using current label instructions. 

26
a. Tolerances Currently Listed and Tolerance Reassessment

Table 6. Tolerance Table 

Commodity Current Reassessed Comments 

Tolerance Tolerance 

(ppm) (ppm) 

Tolerances Listed Under 40 CFR § 180.293 (a)(1) 

Cotton, 0.1 To Be Additional data are required. Data submitted 

Undelinted Seed Determined 

(TBD) 

by the registrant was performed in the wrong 

geographic area, used incorrect rates, the 

wrong pre-harvest interval, and the cotton 

was delinted prior to analysis. 

Hop 0.1 TBD Additional data are required. Submitted data 

does not support 24(c) registrations. Change 

commodity name to Hop, Dried Cones 

Potato 0.1 TBD Additional data are required. Data submitted 

by the registrant used incorrect application 

rate. 

Rice, Grain 0.05 (N) TBD Although there are presently no registered 

uses on rice, the Agency recommends the 

retention of these tolerances until the 

Rice, Straw 0.05 (N) TBD 

registrant has submitted the requested 

irrigation crop data that should include data 

for rice commodities. 

Tolerance Listed Under 40 CFR § 180.293 (a)(2) 

Potable Water 0.2 Revoke 

Tolerance 

EPA's Office of Pesticide Programs no longer 

establishes tolerances in drinking water. 

EPA's Office of Water has established an 

MCL for endothall at 0.1 ppm 

Tolerance Listed Under 40 CFR § 180.319 

Beet, Sugar 0.2 TBD Additional data are required. Although there 

are presently no registered uses on sugar 

beets, the Agency recommends the retention 

of the interim tolerance until the registrant 

has submitted the requested irrigation crop 

data. Residue data must include data for both 

sugar beet root and tops. Change commodity 

name to Beet, sugar, root. 

Tolerances to be Proposed Under 40 CFR § 180.293 

Cotton Gin NA TBD A tolerance for cotton gin byproducts will 

Byproducts need to be proposed when requesting cotton 

field trials and have been received and 

evaluated. 

Animal NA TBD Tolerances for animal commodities will need 

Commodities to be proposed when the requested cotton 

field trials have been received and evaluated. 

Processed 

Commodities 

NA TBD Tolerances for processed commodities may 

be needed if the levels of endothall residues 

expected in processed commodities are found 

to be significantly higher than the raw 

agricultural commodities. 

27
Commodity Current Reassessed Comments 

Tolerance Tolerance 

(ppm) (ppm) 

Fish and Shellfish NA TBD Tolerances that have been propo sed for fish 

and shellfish may become acceptable after 

the appropriate stability data and 

independently validated enforcement method 

have been submitted. 

NOTE: The Agency has no dietary, drinking water, or residential risk concerns associated with these 

tolerances and consider them reassessed at the current tolerance level. The "TBD" designation is used, 

however, to convey that the Agency expects that the data required in the DCI that will be issued as a result 

of this RED will confirm that conclusion. 

D. Regulatory Rationale

The Agency has determined that endothall is eligible for reregistration provided 

that additional required data are sub mitted to confirm this decision that the risk mitigation 

measures outlined in this document are adopted, and label amendments are made to 

reflect these measures. This decision considers the risk assessments conducted by the 

Agency and the significance of the use of endothall. 

The following is a summary of the rationale for managing risks associated with 

the use of endothall. Where labeling revisions are warranted, specific language is set 

forth in the summary tables in Section V of this document. 

1. Human Health Risk Management

a. Dietary Risk Mitigation (food and drinking water) 

As discussed in sections III.A.4 and 5, chronic dietary risks (food and drinking 

water) do not exceed the Agency's level of concern, although drinking water risk for 

infants less than one year old is at the level of concern. The Agency believes that this 

risk estimate is the result of conservative assumptions used in the risk assessment. 

However, to ensure that dietary (food and drinking water) risks are below the Agency's 

level of concern, drinking water intake setbacks will be added to endothall labels for 

aquatic uses. The following language will be added to aquatic use labels: 

"Drinking Water (Potable Water) 

� Consult with appropriate state or local water authorities before applying this 

product to public waters. State or local agencies may require permits. The 

drinking water (potable water) restrictions on this label are to ensure that 

consumption of water by the public is allowed only when the concentration of 

endothall is the water is less than the MCL (Maximum Contaminant Level) of 0.1 

ppm. Applicators should consider the unique characteristics of the treated waters 

to assure that endothall concentrations in potable drinking water do not exceed 0.1 

ppm at the time of consumption. 

28
� For applications of endothall, the drinking water setback distance from 

functioning potable water intakes is greater than or equal to 600 feet.

� Note: Existing potable water intakes that are no longer in use, such as those 

replaced by a connection to a municipal water system or a potable water well, are 

not considered to be functioning potable water intakes. 

� Drinking water setbacks distances do not apply to terrestrial applications of 

endothall adjacent to water bodies with potable water intakes." 

b. Occupational Risk Mitigation

As discussed in Section III.A.8.a, most occupational exposure scenarios are below 

the Agenc y's level of concern. However, some mitigation is required to protect workers 

in scenarios the Agency has indicated might result in a risk to workers. To protect 

workers mixing and loading liquid formulations for aerial applications to terrestrial sites, 

workers are required to wear an 80% (PF5) respirator (NIOSH TC-21C). To protect 

workers mixing, loading, and applying liquid formulations for aquatic applications, 

workers must wear an 80% (PF5) respirator (NIOSH TC-21C). To protect workers 

loading and applying granular formulations for aquatic uses, workers are required to wear 

a 90% (PF10 eslastomeric half face respirator with appropriate cartridge) respirator 

(NIOSH TC-23C or NIOSH TC-14G). Specific label language will include: 

� During granular applications, the respirator need not be worn, provided that the 

pesticide is applied in a manner (such as aerial application or subsurface release 

or from the rear of a vessel that is moving into the wind) that the applicator will 

have no contact with the pesticide. 

� During liquid applications, the respirator need not be worn, provided that the 

pesticide is applied in a manner (such as direct metering or subsurface release 

from the rear of a vessel that is moving into the wind) that the applicator will have 

no contact with the pesticide. 

The Agency has determined that endothall is a severe dermal irritant. Label 

requirements addressing dermal effects will be addressed when toxicity data is submitted 

for end-use products. The Agency will require personal protective equipment based on 

end-use product toxicity during product reregistration. 

To protect workers from exposures during post-application activities, the re-entry 

interval of 48 hours will remain for agricultural workers (terrestrial applications). 

Because endothall is a severe skin irritant, the Agency is requiring that double 

notification statements be added to labels intended for terrestrial use. 

c. Residential Risk Mitigation

Although the Agency did not identify any residential use scenarios that resulted in 

risk concerns, the following statement will be put on labels addressing residential uses: 

29
"Consult local and state fish and game agency and water control authorities before 

applying this product. Permits may be required to treat such water." 

2. Environmental Risk Management

To address risks to aquatic organisms, additional directions for use and use 

restrictions will be added to product labels to reduce potential risks. Specific language 

and restrictions are different for the dipotassium salt and the N, N-dimethylalkylamine 

salt, and are discussed below. 

a. Dipotassium Salt

The Agency is requiring that labels for the dipotassium salt form of endothall 

specify different rates for different size applications. This language will specify that for 

large treatment areas, lower rates of endothall dipotassium salt must be used. For 

smaller, spot treatments, higher rates of endothall dipotassium salt can be used. For 

example, to treat infestations of Coontail, large areas can be treated with rates of 1-2 ppm 

and small areas can be treated using higher rates (2-3 ppm). Specific language will 

include: 

"Only use higher rates (see above example) when making treatments to small 

areas with an increased potential for rapid dilution or when making long and narrow 

applications such as for boat lanes or shoreline treatments where dilution may reduce the 

exposure of plants and the herbicide." 

"Use the lower rates (see above example) for large contiguous treatment blocks, 

or in protected areas such as coves where reduced water movement will not result in 

rapid dilution of the herbicide from the target treatment area or when treating entire lakes 

or ponds." 

b. N, N-dimethylalkylamine Salt 

The Agency is requiring that products used in lakes, ponds, streams, and other 

bodies of water are limited to applications to control algae, Hygrophila, Vallisneria, 

Hydrilla, Cabomba, bur weed, Elodea canadensis and Brazilian elodea. The following 

plants are to be removed from endothall N, N-dimethylalkylamine labels: Coontail, 

Milfoil, Naiad (Najas spp.), Pondweed (Potamogeton spp.), Water Stargrass, and 

Zannichellia. 

3. Significance of Endothall Use

Endothall is an important part of aquatic weed and algae management. Currently 

there are not many aquatic herbicide alternatives available. Although endothall 

potentially poses risks to non-target plants and aquatic organisms, typical use patterns 

30
and additional label requirements required in this RED will reduce exposure to non-target 

organisms while maintaining its most important uses. 

The N, N-dimethylalkylamine salt is an important tool for controlling algae and 

aquatic weeds that cannot be controlled with endothall dipotassium salt. Typical rates 

used to control algae are low (0.05-0.3 ppm). In addition, RQs were calculated using a 

range of rates from 0.5 to 5 ppm. Therefore, RQs that were calculated using the lowest 

rate of 0.5 ppm potentially overestimates risk. When algae are dense, and a higher rate is 

needed, labels require that application areas are limited to no more than 10% of the water 

body. Further, when algae are dense, oxygen levels in the water are low. When 

conditions such as this exist, fish generally are not present and will not likely be exposed 

to high application rates. In addition, as required mitigation in this RED, the N, Ndimethylalkylamine salt will only be used on a select set of vascular plants (Hygrophila, 

Vallisneria, Hydrilla, Cabomba, bur weed, Elodea Canadensis and Brazilian elodea). 

Previous labels allowed use on Coontail, Milfoil, Naiad (Najas spp.), Pondweed 

(Potamogeton spp.), Water Stargrass, and Zannichellia. Current labels warn of toxicity to 

fish and aquatic organisms and do not recommend applications above 0.3ppm where fish 

are important resources. Another important aspect of N, N-dimethylalkylamine salt use 

is that commercial applicators are required to apply rates above 0.3 ppm and must get the 

appropriate state permitting to make an application. 

Endothall dipotassium salt is an important part of aquatic weed management and 

controlling submerged aquatic vegetation. Although use of endothall dipotassium salt 

poses risks to non-target plants and aquatic organisms, typical use patterns will minimize 

exposure to non-target organisms. For example, higher rates of the dipotassium salt are 

used only for spot treatments in small areas where dense weeds are problematic. Large 

areas that require weed control with the dipotassium salt are treated with lower rates and 

entire bodies of water are not typically treated at one time. Similar to the N, Ndimethylalkylamine salt, proper permitting and approval is required. 

In addition to the importance of aquatic uses of endothall, the terrestrial use of N, 

N-dimethylalkylamine salt is an important desiccant. The terrestrial use of N, Ndimethylalkylamine salt is minimal. Applications of endothall as a desiccant are reserved 

for sites where use of other desiccants poses risks to adjacent fields. Additionally, 

terrestrial application rates of endothall N, N-dimethylalkylamine salt are very low. 

Together, the minimal use and low application rates minimize risks to terrestrial 

organisms. 

4. Other Labeling Requirements

In order to be eligible for reregistration, endothall use and safety information will 

be included in the labeling of all end-use products containing endothall. For the specific 

labeling statements and a list of outstanding data, refer to Section V of this RED 

document. 

31
5. Threatened and Endangered Species Considerations 

a. The Endangered Species Program

The Agency has developed the Endangered Species Protection Program to 

identify pesticides whose use may cause adverse impacts on threatened and endangered 

species, and to implement mitigation measures that address these impacts. The 

Endangered Species Act requires federal agencies to ensure that their actions are not 

likely to jeopardize listed species or adversely modify designated critical habitat. To 

analyze the potential of registered pesticide uses that may affect any particular species, 

EPA uses basic toxicity and exposure data developed for the REDs and the n considers 

ecological parameters, pesticide use information, geographic relationship between 

specific pesticide uses and species locations, and biological requirements and behavioral 

aspects of the particular species. When conducted, this species-specific analysis will also 

consider the risk mitigation measures that are being implemented as a result of this RED. 

Following this future species-specific analysis, a determination that there is a 

likelihood of potential effects to a listed species may result in limitations on use of the 

pesticide, other measures to mitigate any potential effects, or consultations with the Fish 

and Wildlife Service and/or the National Marine Fisheries as appropriate. If the Agency 

determines use of endothall "may effect" listed species or their designated critical habitat, 

EPA will employ the provisions in the Services regulations (50 CFR Part 402). Until a 

species specific analysis is completed, the risk mitigation measures being implemented 

through this RED will reduce the likelihood that endangered and threatened species may 

be exposed to endothall at levels of concern. EPA is not requiring specific endothall 

label language at the present time relative to threatened and endangered species. If, in the 

future, specific measures are necessary for the protection of listed species, the Agency 

will implement them through the Endangered Species Program. 

b. General Risk Mitigation

Endothall end-use products (EUPs) may also contain other registered pesticides. 

Although the Agency is not proposing any mitigation measures for products containing 

endothall specific to federally listed threatened and endangered species, the Agency 

needs to address potential risks from other end-use products. Therefore, the Agency 

requires that users adopt all threatened and endangered species risk mitigation measures 

for all active ingredients in the product. If a product contains multiple active ingredients 

with conflicting threatened and endangered species risk mitigation measures, the more 

stringent measure(s) must be adopted. 

32
V. What Registrants Need to Do

The Agency has determined that endothall is eligible for reregistration provided 

that: (i) additional data that the Agency intends to require to confirm this decision; (ii) the 

risk mitigation measures outlined in this document are adopted; and (iii) label 

amendments are made to reflect these measures. To implement the risk mitigation 

measures, the registrants must amend their product labeling to incorporate the label 

statements set forth in the Label Changes Summary Table in Section B below (Table 6). 

The additional data requirements that the Agency intends to obtain will include, among 

other things, submission of the following: 

For endothall technical grade active ingredient products, the registrant needs to 

submit the following items: 

Within 90 days from the receipt of the generic data call in (DCI): 

1. Completed response forms to the generic DCI (i.e., DCI response form and 

requirement status and registrant's response form); and 

2. Submit any time extension and/or waiver requests with a full written 

justification. 

Within the time limit specified in the generic DCI: 

1. Cite any existing generic data which address data requirements or submit new 

generic data responding to the DCI. 

Please contact Anne Overstreet at (703) 308-8068 with questions regarding generic 

registration.

By US Mail: By express or courier service:

Document Processing Desk (DCI/SRRD) Document Processing Desk (DCI/SRRD)

Anne Overstreet Anne Overstreet

US EPA (7508C) Office of Pesticide Programs (7508C)

1200 Pennsylvania Ave., NW Room 266A, Crystal Mall 2

Washington, DC 20460 1801 S. Bell Street

Arlington, VA 22202 

For end-use products containing the active ingredient endothall, the registrant 

needs to submit the following items for each product: 

Within 90 days from the receipt of the product-specific data call-in (PDCI): 

33 
1. Completed response forms to the PDCI (i.e., PDCI response form and 

requirement status and registrant's response form); and 

2. Submit any time extensions and/or waiver requests with a full written 

justification. 

Within eight months from the receipt of the PDCI: 

1. Two copies of the confidential statement of formula (EPA Form 8570-4); 

2. A completed original application for reregistration (EPA Form 8570-1). 

Indicate on the form that it is an "application for reregistration"; 

3. Five copies of the draft labeling incorporating all the label amendments 

outlined in Table 7 of this document; 

4. A completed form certifying compliance with data compensation requirements 

(EPA Form 8570-34); 

5. If applicable, a completed form certifying compliance with cost share offer 

requirements (EPA Form 8570-32); and 

6. The product-specific data responding to the PDCI. 

Please contact Venus Eagle at (703) 308-8045 with questions regarding product 

reregistration and/or the PDCI. All materials in response to the PDCI should be 

addressed as follows: 

By US Mail:

Document Processing Desk 

(PDCI/SRRD/PRB)

Venus Eagle

US EPA (7508C)

1200 Pennsylvania Ave., NW

Washington, DC 20460

By express or courier service: 

Document Processing Desk 

(PDCI/SRRD/PRB) 

Venus Eagle 

Office of Pesticide Programs (7508C) 

Room 266A, Crystal Mall 2 

1801 S. Bell Street 

Arlington, VA 22202 

A. Manufacturing Use Products

1. Additional Generic Data Requirements

The generic database supporting the reregistration of endothall has been reviewed 

and determined to be substantially complete. However, the following additional data 

34
requirements have been identified by the Agency as confirmatory and are included in the 

generic DCI for this RED. 

Table 7. Confirmatory Data Requirements for Reregistration 

Guideline Number Study/Requirements 

71-4 Avian Chronic Reproduction study in quail or duck using N,N-dimethylalkylamine 

(850.2300) salt 

72-4C 

(850.1400) Estuarine/Marine Fish Early Life-Stage Study using N,N-dimethylalkylamine salt 

72-4B Estuarine/Marine Invertebrate Early Life -Stage study using N,N-

(850.1350) dimethylalkylamine salt 

72-5 

(850.1500) Fish Life-Cycle study using N,N-dimethylalkylamine salt 

850.1735 Acute Freshwater Sediment study using N,N-dimethylalkylamine salt 

850.1740 Acute Estuarine/Marine Sediment study using N,N-dimethylalkylamine salt 

Special Study Chronic Estuarine/Marine Sediment Testing using N,N-dimethylalkylamine salt 

Special Study 65-day Test in Chironomus tentans using N,N-dimethylalkylamine salt 

83-3B 

(870.3700B) Developmental/Teratology in Non-rodent (rabbit) study 

82-4 

(870.3465) 28-day Inhalation study 

171-4C & D 

(860.1340) 

Residue Analytical Method-Plants and Animals. Radiovalidation data needed to 

determine whether the current enforcement methods for plants and the required 

enforcement method(s) for animals can adequately extract and convert aged 

residues of the monomethyl ester to endothall. 

171-4D Data collection and regulatory analytical methods are needed for the determination 

(860.1340) of endothall, per se, in animal commodities 

171-4 Submission of analytical reference standards for dipotassium and mono-N,N-

(860.1340) dimethylalkylamine salts of endothall 

171-4E Storage stability data for processed plant commodities, animal commodities, and 

(860.1380) fish 

171-4J 

(860.1480) Livestock (ruminant and poultry) feeding studies 

171-4H 

(860.1400) Magnitude of residues in irrigated crops 

171-4L 

(860.1520) 

Magnitude of residue studies in potato, alfalfa seed, cotton seed, and cotton gin 

products. Magnitude of residue studies in raw agricultural commodities of sugar 

beet and rice if the registrant is supporting these uses 

171-4L Processing studies on apples, field corn, grapes, orange, rice, sorghum, soybeans, 

(860.1520) sugar beet, tomato, and wheat to cover irrigation uses 

165-1 A confined, rotational crop study after treatment at the proper maximum labeled 

(860.1850) rate for irrigation water 

2. Labeling for Technical and Manufacturing Use Products 

To ensure compliance with FIFRA, technical and manufacturing use products 

(MP) labeling should be revised to comply with all current EPA regulations, PR Notices 

and applicable policies. The technical and MP labeling should bear the labeling 

contained in Tables 8 and 9, Label Changes Summary Table. 

35
B. End-Use products 

1. Additional Product-Specific Data Requirements 

Section 4(g) (2) (B) of FIFRA calls for the Agency to obtain any needed productspecific data regarding the pesticides after a determination of eligibility has been ma de. 

The registrant must review previous data submissions to ensure they meet current EPA 

acceptance criteria and if not, commit to conduct new studies. If a registrant believes that 

previously submitted data meet current testing standards, then the study MRID numbers 

should be cited according to the instructions in the Requirement Status and Registrations 

Response Form provided for each product. 

A product-specific data call-in, outlining specific data requirements, accompanies 

this RED. 

2. Labeling for End-Use Products 

Labeling changes are necessary to implement measures outlined in Section IV 

above. Specific language to incorporate these changes is specified in the Label Changes 

Summary Table below. 

Existing stocks time frames will be established case by case, depending on the 

number of products involved, the number of label changes, and other factors. Refer to 

"Existing Stocks of Pesticide Products; Statement of Policy," Federal Register, Volume 

56, No. 123, June 26, 1991. 

a. Label Changes Summary Table

In order to be eligible for reregistration, amend all product labels to incorporate 

the risk mitigation measures outlined in Section IV. The following table describes how 

language on the labels should be amended. 

36
Table 8. Summary of Required Labeling Changes for Products Registered for Aquatic Uses Only of Endothall 

Description Required Labeling Language Placement on Label 

Manufacturing-Use Products 

Required on all Manufacturing "Only for formulation into an herbicide for the following use(s) [fill blank only with those Directions for Use 

Use Products uses that are being supported by the MP registrants]." 

One of these statements may be AThis product may be used to formulate products for specific use(s) not listed on the MP Directions for Use 

added to allow reformulation of label if the formulator, user group, or grower has complied with U.S. EPA submission 

the product for a specific use or requirements regarding support of such use(s).@ 

all additional uses supported by 

a formulator or user group. AThis product may be used to formulate products for any additional use(s) not listed on the 

MP label if the formulator, user group, or grower has complied wit h U.S. EPA submission 

requirements regarding support of such use(s).@ 

Environmental Hazards AThis pesticide is toxic to fish and aquatic invertebrates. Do not discharge effluent Directions for Use 

Statements Required by the 

RED and Agency Label 

Policies 

containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless 

in accordance with the requirements of a National Pollutant Discharge Eliminations System 

(NPDES) permit and the permitting authority has been notified in writing prior to 

discharge. Do not discharge effluent containing this product to sewer systems without 

previously notifying the local sewage treatment plant authority. For guidance, contact your 

State Water Board or Regional Office of the Environmental Protection Agency.@ 

End-Use Products Intended of Occupational Use 

Note the following information when preparing labeling for all end-use products: 

For sole-active -ingredient end-use products that contain endothall, the product label must 

be revised to adopt the handler personal protective equipment (PPE)/engineering control 

requirements set forth in this section. Any conflicting PPE requirements on the current 

label must be removed. 

For multi -active -ingredient end-use products that contain endothall, the handler 

PPE/engineering control requirements set forth in this section must be compared with the 

requirements on the current label, and the more protective language must be retained. For 

guidance on which requirements are considered to be more protective, see PR Notice 93-7. 

PPE that is established on the basis of Acute Toxicity testing with end-use products must 

be compared with the active ingredient PPE specified below in this document. The more 

protective PPE must be placed in the product labeling. For example, the Handler PPE in 

this RED does not require protective eyewear which may be required by the Acute Toxicity 

37
Description Required Labeling Language Placement on Label 

testing for the end-use product. For guidance on which PPE is considered more protective, 

see PE Notice 93-7. 

Handler PPE Requirements for 

Liquid Formulations for 

Aquatic Applications 

"Mixers, loaders, applicators, and other handlers must wear: 

-long-sleeve shirt, 

-long pants, 

Precautionary Statements: 

Hazards to Humans and 

Domestic Animals 

-shoes and socks, and 

-a NIOSH-approved respirator with a dust/mist filter with MSHNA/NIOSH approval 

number prefix TC-21C or any N, R, P, or He filter. 

Exception: during application, the respirator need not be worn, provided that the pesticide 

is applied in a manner (such as direct metering or subsurface release from the rear of a 

vessel that is moving into the wind) that the applicator will have no contact with the 

pesticide. 

See engineering controls for additional options." 

Handler PPE Requirements for 

Granular Formulations for 

Aquatic Applications 

"Mixers, loaders, applicators, and other handlers must wear: 

-long-sleeve shirt, 

-long pants, 

-shoes and socks, and 

-a NIOSH-approved half- or full-face respirator with a cartridge approved for dusts and 

mists or a canister approved for dusts and mists or a cartridge with any N*, R, P, or He 

filter. Note: the quarter-face cup-style respirator does not meet this requirement. 

Exception: during application, the respirator need not be worn, provided that the pesticide 

is applied in a manner (such as aerial application or subsurface release or from the rear of a 

vessel that is moving into the wind) that the applicator will have no contact with the 

pesticide. 

See optional engineering controls for additional instructions." 

*Instruction to registrant: Drop the "N" type pre-filter from the response statement if the 

pesticide product contains, or is used with, oil. 

Engineering Controls: Liquid Engineering Control Statement for Optional Use (WPS only) Precautionary Statements: 

Formulations Only Hazards to Humans and 

"Engineering Controls: Domestic Animals 

(Immediately following PPE 

38
Description Required Labeling Language Placement on Label 

"When mixers and loaders use a closed system designed by the manufacturer to enclose the and User Safety Requirements) 

pesticide to prevent it from contacting handlers or other people AND the system is 

functioning properly and is used and maintained in accordance with the manufacturers 

written operating instructions, the handlers need not wear a respirator, provided the 

required respirator is immediately available for use in an emergency such as a spill or 

equipment breakdown." 

Engineering Controls: Enclosed "Engineering Controls: Precautionary Statements: 

Cockpit for Granular Aerial Hazards to Humans and 

Applicators Pilots must used an enclosed cockpit that meets the requirements listed in the WPS for Domestic Animals 

agricultural pesticides [40 CFR 170.240(d) (6)." (Immediately following PPE 

and User Safety Requirements) 

User Safety Requirements AFollow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions Precautionary Statements: 

for washables exist, use detergent and hot water. Keep and wash PPE separately from 

other laundry.@ 

Hazards to Humans and 

Domestic Animals 

(Immediately following PPE 

ADiscard clothing or other absorbent materials that have been drenched or heavily 

contaminated with this product=s concentrate. Do not reuse them.@ 

and User Safety Requirements) 

User Safety Recommendations AUSER SAFETY RECOMMENDATIONS@ Precautionary Statements 

under: Hazards to Humans and 

AUsers should wash hands before eating, drinking, chewing gum, using tobacco, or using 

the toilet.@ 

Domestic Animals immediately 

following Engineering Controls 

AUsers should remove clothing/PPE immediately if pesticide gets inside. Then wash 

thoroughly and put on clean clothing.@ 

(Must be placed in a box.) 

AUsers should remove PPE immediately after handling this product. Wash the outside of 

gloves before removing. As soon as possible, wash thoroughly and change into clean 

clothing.@ 

Environmental Hazards "ENVIRONMENTAL HAZARDS" Precautionary Statements under 

Environmental Hazards 

"This pesticide is toxic to fish. This pesticide is toxic to wildlife. " 

"Do not contaminate water by cleaning of equipment or disposal of equipment wash 

waters. Do not contaminate water, food, or feed by storage or disposal." 

39
Description Required Labeling Language Placement on Label 

Applications Restrictions for all "Do not apply this product in a way that will contact workers or other persons, either Directions for Use directly 

products applied as a spray directly or through drift." above the Agricultural Use Box 

Application Restrictions for "Aerial application is prohibited." Directions for Use (near the 

Aquatic Applications-Liquids beginning of the section) 

Formulations Only 

Other Use/Application 

Restrictions 

Streams, Rivers, Channeled Water: Do not contaminate water intended for irrigation or 

domestic purposes. Do not use water for spraying or irrigation within 7 days after 

treatment. 

Directions for Use under 

General Precautions and 

Restrictions and/or Application 

Instructions 

Swamps, Marshland, Wetlands, Stagnant Water: Do not contaminate water intended for 

irrigation or domestic purposes. 

Human Drinking Water Systems: Do not contaminate water intended for irrigation or 

domestic purposes. 

Commercial, Industrial Water Cooling Systems: Do not discharge the effluent 

containing this pesticide into sewage systems without notifying the sewage treatment plant 

authority (POTW). Do not discharge effluent containing this product into lakes, streams, 

ponds, estuaries, oceans, or public water (NPDES license restrictions). 

Other Use/Application 

Restrictions 

Drinking Water (Potable Water) 

� Consult with appropriate state or local water authorities before applying this 

product to public waters. State or local agencies may require permits. The 

drinking water (potable water) restrictions on this label are to ensure that 

consumption of water by the public is allowed only when the concentration of 

endothall is the water is less than the MCL (Maximum Contaminant Level) of 0.1 

ppm. Applicators should consider the unique characteristics of the treated waters 

to assure that endothall concentrations in potable drinking water do not exceed 0.1 

ppm at the time of consumption. 

Directions for Use under 

General Precautions and 

Restrictions and/or Application 

Instructions 

� For applications of endothall, the drinking water setback distance from 

functioning potable water intakes is greater than or equal to 600 feet. 

� Note: Existing potable water intakes that are no longer in use, such as those 

40
Description Required Labeling Language Placement on Label 

replaced by a connection to a municipal water system or a potable water well, are 

not considered to be functioning potable water intakes. 

� Drinking water setbacks distances do not apply to terrestrial applications of 

endothall adjacent to water bodies with potable water intakes." 

Additional Use/Application 

Restrictions for Endothall 

Dipotassium Salt 

"Only use higher rates when making treatments to small areas with an increased potential 

for rapid dilution or when making long and narrow applications such as for boat lanes or 

shoreline treatments where dilution may reduce the exposure of plants and the herbicide." 

"Use lower rates for large contiguous treatment blocks or in protected areas such 

as coves where reduced water movement will not result in rapid dilution of the herbicide 

from the target treatment area or when treating entire lakes or ponds." 

Additional Use/Application 

Restrictions for Endothall N, NDimethylalkylamine Salt 

All Water bodies (except Irrigation Canals/Ditches): Use of endothall N, Ndimethylalkylamine salt is limited to algae and the following plants: 

Hygrophila, Vallisneria, Hydrilla, Cabomba,

 bur weed, Elodea canadensis, and Brazilian elodea. 

Lakes, Ponds, Reservoirs (with human or wildlife use): Do not contaminate water 

intended for irrigation or domestic purposes. Do not use water for domestic purposes until 

25 days after treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment 

of 0.3 ppm. Do not use treated water for animal consumption within 25 days of treatment 

of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use 

treated water for spraying or irrigation within 25 days of treatment of 5 ppm, 14 days for 

treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use where fish are 

important resources. Do not treat more than 10% of the area at one time with doses in 

excess of 1 ppm. 

Agricultural Drainage Systems, Drainage Systems: Do not use water for domestic 

purposes until 25 days after treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days 

for treatment of 0.3 ppm. Do not use treated water for animal consumption within 25 days 

of treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. 

Do not use treated water for spraying or irrigation within 25 days of treatment of 5 ppm, 14 

days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use where fish 

are important resources. Do not treat more than 10% of the area at one time with doses in 

excess of 1 ppm. 

41
Table 9. Summary of Required Labeling Changes for Products Registered for Terrestrial Uses Only of Endothall 

Description Required Labeling Language Placement on Label 

Manufacturing-Use Products 

Required on all Manufacturing "Only for formulation into an herbicide for the following use(s) [fill blank only with those Directions for Use 

Use Products uses that are being supported by the MP registrants]." 

One of these statements may be AThis product may be used to formulate products for specific use(s) not listed on the MP Directions for Use 

added to allow reformulation of label if the formulator, user group, or grower has complied with U.S. EPA submission 

the product for a specific use or requirements regarding support of such use(s).@ 

all additional uses supported by 

a formulator or user group. AThis product may be used to formulate products for any additional use(s) not listed on the 

MP label if the formulator, user group, or grower has complied with U.S. EPA submission 

requirements regarding support of such use(s).@ 

Environmental Hazards AThis pesticide is toxic to fish and aquatic invertebrates. Do not discharge effluent Directions for Use 

Statements Required by the 

RED and Agency Label 

Policies 

containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless 

in accordance with the requirements of a National Pollutant Discharge Eliminations System 

(NPDES) permit and the permitting authority has been notified in writing prior to 

discharge. Do not discharge effluent containing this product to sewer systems without 

previously notifying the local sewage treatment plant authority. For guidance, contact your 

State Water Board or Regional Office of the Environmental Protection Agency.@ 

End-Use Products Intended of Occupational Use 

Note the following information when preparing labeling for all end-use products: 

For sole-active -ingredient end-use products that contain endothall, the product label must 

be revised to adopt the handler personal protective equipment (PPE)/engineering control 

requirements set forth in this section. Any conflicting PPE requirements on the current 

label must be removed. 

For multi -active -ingredient end-use products that contain endothall, the handler 

PPE/engineering control requirements set forth in this section must be compared with the 

requirements on the current label, and the more protective language must be retained. For 

guidance on which requirements are considered to be more protective, see PR Notice 93-7. 

PPE that is established on the basis of Acute Toxicity testing with end-use products must 

be compared with the active ingredient PPE specified below in this document. The more 

protective PPE must be placed in the product labeling. For example, the Handler PPE in 

this RED does not require protective eyewear which may be required by the Acute Toxicity 

42
Description Required Labeling Language Placement on Label 

testing for the end-use product. For guidance on which PPE is considered more protective, 

see PE Notice 93-7. 

Handler PPE Requirements "Mixers, loaders, applicators, and other handlers must wear: 

-long-sleeve shirt, 

-long pants, 

-shoes and socks." 

"In addition, mixers and loaders supporting aerial applications must wear: 

-NIOSH-approved respirator with a dust/mist filter with MSHNA/NIOSH approval number 

prefix TC-21C or any N*, R, P, or He filter." 

*Instruction to registrant: drop the "N" type pre-filter from the respirator statement if the 

pesticide product contains, or is used with, oil. 

"See engineering controls for additional requirements." 

Precautionary Statements: 

Hazards to Humans and 

Domestic Animals 

Engineering Controls 

"Engineering Controls: 

Pilots must use an enclosed cockpit that meets the requirements listed in the WPS for 

agricultural pesticides [40 CFR 170.240(d)(6). 

Human flagging is prohibited. Flagging to support aerial applications is limited to use of 

the Global Positioning System (GPS) or mechanical flaggers. 

When handlers use closed systems, enclosed cabs, or cockpits in a manner that meets the 

requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides (40 

CFR 170.240(d)(4-6), the handler PPE requirements may be reduced or modified as 

specified in the WPS." 

Precautionary Statements: 

Hazards to Humans and 

Domestic Animals 

(Immediately following PPE 

and User Safety Requirements) 

User Safety Requirements AFollow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions 

for washables exist, use detergent and hot water. Keep and wash PPE separately from 

other laundry.@ 

ADiscard clothing or other absorbent materials that have been drenched or heavily 

Precautionary Statements: 

Hazards to Humans and 

Domestic Animals 

(Immediately following PPE 

and User Safety Requirements) 

43
Description Required Labeling Language Placement on Label 

contaminated with this product=s concentrate. Do not reuse them.@ 

User Safety Recommendations AUSER SAFETY RECOMMENDATIONS@ Precautionary Statements 

under: Hazards to Humans and 

AUsers should wash hands before eating, drinking, chewing gum, using tobacco, or using 

the toilet.@ 

Domestic Animals immediately 

following Engineering Controls 

AUsers should remove clothing/PPE immediately if pesticide gets inside. Then wash 

thoroughly and put on clean clothing.@ 

(Must be placed in a box.) 

AUsers should remove PPE immediately after handling this product. Wash the outside of 

gloves before removing. As soon as possible, wash thoroughly and change into clean 

clothing.@ 

Environmental Hazards "ENVIRONMENTAL HAZARDS" Precautionary Statements under 

Environmental Hazards 

"Do not apply directly to water, or to areas where water is present to intertidal areas below 

the mean high water mark. This pesticide is toxic to fish. This pesticide is toxic to 

wildlife. Keep out of lakes, streams, and ponds." 

Applications Restrictions for all "Do not apply this product in a way that will contact workers or other persons, either Directions for Use directly 

products applied as a spray directly or through drift." above the Agricultural Use Box 

Restricted-Entry Interval for "Do not ender or allow worker entry into treated areas during the restricted entry interval Directions for Use, Agricultural 

WPS products as required by (REI) of 48 hours." Use Requirements Box 

Supplement Three of PR Notice 

93-7 

Early Re-Entry Personal "PPE required for early entry to treated areas that is permitted under the WPS and that Directions for Use, Agricultural 

Protective Equipment for involves contact with anything that has been treated, such as soil or water, is: Use Requirements Box 

Products subject to WPS as 

required by Supplement Three -coveralls over long sleeved shirt and long pants, 

of PR Notice 93-7 -chemical-resistant gloves made of any waterproof material, 

-chemical-resistant footwear plus socks, 

-protective eyewear, and 

-headgear for overhead exposure. 

Double Notification Statement "Notify workers of the application by warning them orally and by posting warning signs at Agricultural Use Requirements, 

entrances to treated area" following Early Entry PPE and 

REI statements 

Other Use/Application "Treated crops must be harvested by mechanical means only. Do not contaminate water by Directions for Use Associated 

Restrictions cleaning of equipment or disposal of equipment wash waters. Do not contaminate water, with Each Crop 

44
Description Required Labeling Language Placement on Label 

food, or feed by storage or disposal. Do not apply through any type of irrigation system. 

Do not apply where drift is likely to occur. 

Alfalfa and Clover: Do not feed treated fodder and/or forage to animals being finished for 

slaughter. Do not graze treated areas. Do not use seed for food, feed, or oil purposes. 

Grown for seed only. 

Hops: Do not feed treated fodder and/or forage to animals being finished for slaughter. 85­

day Pre-Harvest Interval (PHI) 

Potato: Do not feed treated forage to animals being finished for slaughter. Do not graze 

treated areas. 14-day PHI. 

Cotton: 7-day PHI. 

Spray Drift Label Language for RELEASE HEIGHT: Directions for Use under 

Products Applied as a Spray "Apply using a nozzle height of no more than 4 feet above the ground or canopy cover." General Precautions and 

through Ground Equipment Restrictions 

Spray Drift Label Language for 

Products Applied as a Spray 

through Airblast Equipment 

"Sprays must be directed into the crop canopy." 

"Outward pointing nozzles should be turned off at row ends and when spraying outer 

rows." 

Directions for Use under 

General Precautions and 

Restrictions 

TEMPERATURE INVERSIONS: 

"If applying at wind speeds less that 3 miles per hour, the applicator must determine if a) 

conditions of temperature inversion exist, or b) stable atmospheric conditions exist at or 

below nozzle height. Do not make applications into areas of temperature inversions or 

stable atmospheric conditions." 

Spray Drift Label Language for 

Products Applied as a Spray 

through Aerial Equipment 

RELEASE HEIGHT: 

"Do not release spray at a height greater than 14 feet above the ground or canopy." 

BOOM LENGTH: 

Directions for Use under 

General Precautions and 

Restrictions 

"The boom length must not exceed 70% of the wingspan or 85% of the rotor blade 

diameter." 

SWATH ADJUSTMENT: 

"When applications are made with a cross-wind, the swath will be displaced downwind. 

45
Description Required Labeling Language Placement on Label 

application area by adjusting the path of the aircraft upwind. Leave at least one unsprayed 

at the downwind edge of the treated field." 

The applicator must compensate for this displacement at the downwind edge of the 

46
VI. Appendices

47 
A. Table of Use Patterns for Endothall

Endothall Acid (PC 038901) 

Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

Alfalfa 15.9% SC/L Broadcast via 

Ground or Aircraft 

0.7912 lb 

ae/A 

NS 1-2 Grown for seed only. Do not 

apply through any type of 

Foliar [4581-206] irrigation system. Do not apply 

directly to water, or to areas 

where surface water is present or 

to intertidal areas below the mean 

high water mark. Do not 

contaminate water by cleaning of 

equipment or disposal of 

equipment wash waters. This 

product is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. This 

pesticide is toxic to wildlife. Do 

not feed treated forage to dairy 

animals or anima ls being finished 

for slaughter. Do not graze 

treated areas. Do not use seed for 

food, feed or oil purposes. 

Clover 15.9% SC/L Broadcast via 0.7912 lb NS 1-2 Same as "Alfalfa" 

Ground or Aircraft ae/A 

Foliar [4581-206] 

Cotton 

Pre-harvest 

15.9% SC/L 

[4581-284] 

0.0989 lb 

ae/A 

NS NS PHI=7 

days 

Do not apply through any type of 

irrigation system. Do not apply 

directly to water, or to areas 

where surface water is present or 

to intertidal areas below the mean 

48 
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

high water mark. Do not 

contaminate water by cleaning of 

equipment or disposal of wash 

waters. This product is toxic to 

fish. Do not contaminate water, 

food, or feed by storage or 

disposal. This pesticide is toxic to 

wildlife. 

Hops 

Foliar 

15.9% SC/L 

[4581-206] 

Ground - Basal 

Spray Treatment 

0.9494 lb 

ae/A 

NS 2 PHI=85 

days 

Do not apply through any type of 

irrigation system. Do not apply 

directly to water, or to areas 

where surface water is present or 

to intertidal areas below the mean 

high water mark. Do not 

contaminate water by cleaning of 

equipment or disposal of 

equipment wash waters. This 

product is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. This 

pesticide is toxic to wildlife. Do 

not feed treated forage to dairy 

animals being finished for 

slaughter. Do not graze treated 

areas. 

49
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

15.9% SC/L 1 lb ae/A PHI=28 Do not apply through any type of 

[OR03003600] 

days irrigation system. Do not apply 

directly to water, or to areas 

where surface water is present or 

to intertidal areas below the mean 

high water mark. Do not 

contaminate water by cleaning of 

equipment or disposal of 

equipment wash waters. This 

product is toxic to fish. This 

pesticide is toxic to wildlife. Do 

not graze livestock in treated 

areas. Do not feed treated forage 

and/or fodder to animals being 

finished for slaughter. 

Potato 

(White/Irish) 

15.9% SC/L Broadcast via 

Ground or Aircraft 

1.0549 lb 

ae/A 

NS NS NS PHI=14 

days 

Do not apply through any type of 

irrigation system. Do not apply 

Foliar 

[4581-206] directly to water, or to areas 

where surface water is present or 

to intertidal areas below the mean 

high water mark. Do not 

contaminate water by cleaning of 

equipment or disposal of 

equipment wash waters. This 

product is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. This 

pesticide is toxic to wildlife. Do 

not feed treated forage to dairy 

animals being finished for 

slaughter. Do not graze treated 

areas. 

50
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

Endothall Dipotassium Salt (PC 038904) 

Agricultural 40.3% SC/L Water treatment - 22.5 lbs NS NS NS NS Do not use treated water for 

Drainage Surface or ae/mile spraying or irrigation within 25 

Systems [4581-204] Subsurface- days after treatment. Do not 

Injection apply when drift is likely to occur. 

When Needed Equipment or Do not contaminate water, food, 

Sprayer or feed by storage or disposal. 

Drainage 40.3% SC/L Surface Water 3 ppm (L) NS NS NS NS NS 

Systems Treatment 

When Needed 

[FL87000500] 

40.3% SC/L Water treatment- 57.6 lb Do not contaminate water, food, 

Surface - Aerosol ae/A or fed by storage or disposal 

[GA95000600] can, Aircraft, 

[TN94000200] Sprayer 

[NY98000200] 

[WA96000600] SubsurfaceInjection 

Equipment 

10.1% G Surface Water 

Treatment3.564 ppm (L)/A 

Do not use treated water for 

spraying or irrigation within 7 

[FL98000300] Spreader days after treatment. Do not 

contaminate water, food, or feed 

by storage or disposal. 

Human 40.3%SC/L Water Treatment 57.6 lb NS NS NS NS Do not contaminate water, food, 

Drinking ae/A or feed by storage or disposal. Do 

Water [FL96001500] Surface- Aerosol not contaminate water intended 

Systems can, Aircraft for irrigation or domestic 

purposes. 

When Needed SubsurfaceInjection 

Equipment 

51
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

Irrigation 40.3% SC/L Water Treatment 1 L NS NS NS NS 

Systems 

[AL85000800] 

When Needed 40.3% SC/L Water Treatment 57.6 lb 

ae/A 

Do not contaminate water, food, 

or feed by storage or disposal. Do 

[GA95000600 

0] 

[TN94000200] 

Surface - Aerosol 

can, Aircraft, 

Sprayer 

not contaminate water intended 

for irrigation or domestic 

purposes. Do not use treated 

[NY98000200] 

SubsurfaceInjection 

water for spraying or irrigation 

within 25 days after treatment. 

40.3% SC/L Do not apply when drift is likely

Equipment to occur. 

[4581-204] 

Lakes/Ponds/ 40.3% SC/L Surface Water 3 ppm (L) NS NS NS NS NS 

Reservoirs Treatment 

(with Human [FL87000500] 

or Wildlife 40.3% SC/L Water Treatment 57.6 lb Do not contaminate water, food, 

Use) Surface- ae/A or feed by storage or disposal. Do 

[GA95000600] Aerosol Can, not contaminate water intended 

When Needed [TN94000200] Aerial, Sprayer for irrigation or domestic 

[SC93000100] purposes. Do not use treated 

[4581-204] Subsurface water for spraying or irrigation 

[NY98000200] Treatment within 25 days of treatment. Do 

[TX99000200] 

[WA96000600] 

not apply when drift is likely to 

occur. 

52
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

63% G Surface Water 49.17 lb Do not contaminate water, food, 

[4581-388] 

[NY99000300] 

TreatmentBroadcast, Granule 

Applicator 

ae/A or feed by storage or disposal. Do 

not contaminate water intended 

for irrigation or domestic 

[NY99000300] purposes. Do not use treated 

water for spraying or irrigation 

within 7 days of treatment. Do 

not apply when drift is likely to 

occur. 

10.1% G Surface Water 58.104 lb Do not use treated water for 

Treatment- ae/A spraying or irrigation within 7 

[4581-201] Spreader, Granular days after treatment. Do not 

[FL98000300 Applicator apply when drift is likely to occur. 

(max 3.564 lb Do not contaminate water, food, 

ae/A)] or feed by storage or disposal. 

Streams/ 40.3% SC/L Surface Water 3 ppm (L) NS NS NS NS NS 

Rivers/ Treatment 

Channeled [FL87000500] 

Water 40.3% SC/L Water Treatment 57.6 lb Do not contaminate water, food, 

[WA96000600] 

Surface-Sprayer 

Subsurfaceae/A or feed by storage or disposal. Do not contaminate water intended 

When Needed for irrigation or domestic 

purposes. 

10.1% G 

[FL98000300] 

Surface Water 

Treatment 

3.564 ppm 

(ae) A 

Do not use treated water for 

spraying or irrigation within 7 

days after treatment. Do not 

contaminate water, food, or feed 

by s torage or disposal. 

Swamps/ 40.3 % SC/L Surface Water 3 ppm (L) NS NS NS NS Do not contaminate water, food, 

Marshes/ Treatment or feed by storage or disposal. Do 

Wetlands/ [FL87000500] not contaminate water intended 

53
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

Stagnant 40.3% SC/L Water Treatment 57.6 lb for irrigation or domestic 

Water Surface-Sprayer (ae) A purposes. 

[WA96000600] Subsurface 

When Needed 

Endothall N, N-dimethylalkylamine Salt (PC 038905) 

Agricultural 53% RTU Water Treatment 15.12 lb NS NS NS NS Apply to not more than 10 percent 

Drainage ae/A-ft of surface area of water. 

Systems [AL81000900] 

53 % SC/L 0.2 ppm NS 

(L) 

[IN80000800] 

Alfalfa 15.9% SC/L Broadcast 1.0549 lb NS NS NS NS Grown for seed only. Do not use 

ae/A treated seed for feed, food or oil 

Foliar [CA87003100] purposes. 

[NV87000800] 

15.9% SC/L Broadcast-Ground, 0.6593 lb 

Aerial ae/A 

[ID87001900] 

[WA87003600] 

54
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

53% SC/L Ground-Spray 1.5 qt/L Do not apply through any type of 

[4581-381] (1.001 lb 

ae/A for 

irrigation system. Do not apply 

directly to water, or to areas 

where surface water is present or 

[AZ98000900] AZ98000 

9000 

to intertidal areas below the mean 

high water mark. Do not apply 

when drift is likely to occur. Do 

not contaminate water by cleaning 

of equipment or disposal of 

equipment wash waters. This 

product is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. This 

pesticide is toxic to wildlife. Do 

not use treated seed for feed, food 

53% SC/L 

[4581-381] 

AircraftLow Volume Spray 0.7507 lb 

ae/A 

or oil purposes. Do not graze 

treated areas. Do not feed forage 

to dairy animals or to animals 

being finished for slaughter. 

Grown for seed only. Keep out of 

lakes, streams, and ponds. 

Alfalfa 53% SC/L Aerial-Spray 1.001 lb Grown for seed only. Do not 

Pre-harvest [WA98002900] Ground-Spray 

ae/A apply through any type of 

irrigation system. Keep out of 

[ID98001300] lakes, streams, and ponds. Do not 

[NV98000200] 

[CA99000300] 

contaminate water by cleaning of 

equipment or disposal of 

equipment wash waters. This 

product is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. This 

pesticide is toxic to wildlife. Do 

55
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

not use treated seed for feed, food 

or oil purposes. Do not graze 

treated areas. Do not feed forage 

to dairy animals or to animals 

being finished for slaughter. 

Clover 

Foliar 

53% SC/L 

[4581-381] 

Aircraft-Low 

Volume Spray 

0.7507 lb 

ae/A 

NS NS NS NS Do not apply through any type or 

irrigation system. Do not apply 

directly to water, or to areas 

Ground-Spray where surface water is present or 

to intertidal areas below the mean 

high water mark. Do not apply 

when drift is likely to occur. Do 

not contaminate water by cleaning 

of equipment or disposal or 

equipment wash waters. This 

product is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. This 

pesticide is toxic to wildlife. Do 

not use treated seed for feed, food 

or oil purposes. Do not graze 

treated areas. Do not feed forage 

to dairy animals or to animals 

being finished for slaughter. 

Commercial/ 53% SC/L Water Treatment- 3.0-0.3 NS NS NS NS Do not discharge effluent 

Industrial Metering Pump ppm containing this pesticide into 

Water [4581-380] endothall sewage systems without notifying 

Cooling technical the sewage treatment plant 

Systems authority (POTW). Do not 

discharge effluent containing this 

When Needed product into lakes, streams, ponds, 

estuaries, oceans, or public water 

56
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

(NPDES license restriction). This 

product is toxic to fish. 

Cotton 

Pre-harvest 

15.9% SC/L 

[TX81003200] 

Aerial or ground 

Spray 

0.1319 lb 

ae/A 

NS NS NS PHI= 3 

Days 

Do not apply through any type of 

irrigation system. Do not apply 

directly to water, or to areas 

where surface water is present or 

to intertidal areas below the mean 

high water mark. Do not 

contaminate water by cleaning of 

equipment or disposal of 

equipment wash waters. This 

product is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. This 

pesticide is toxic to wildlife. 

Drainage 53% RTU Surface Treatment- 15.12 lb NS NS NS NS Apply to not more than 10 percent 

Systems [AL81000900] Aerial, Boat ae/A-ft of surface area of water. 

[FL77000100] 

When Needed Injection 

Equipment (max 

11.2 lb ae/A-ft) 

53% SC/L Surface Treatment- 3.1536 lb Do not use treated water for 

[1448-352] 

Injection 

Equipment, 

Ground (Sprayer) 

ae/A-ft domestic purposes until 25 days 

after treatment. Do not use 

treated water for spraying or 

irrigation within 25 days after 

treatment. Do not use treated 

57
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

53% SC/L 13.51 lb water for animal consumption 

[4581-174] 

[TX99000600] 

ae/A-ft within 25 days after treatment. 

Do not apply when drift is likely 

to occur. This product is toxic to 

fish. Do not contaminate water, 

food, or feed by storage or 

disposal. Do not use where fish 

are important resources. 

11.2% G 

[4581-172] 

Water TreatmentAerial, Ground 13.5 lb 

ae/A-ft 

Do not apply when drift is likely 

to occur. This product is toxic to 

fish. Do not contaminate water, 

food, or feed by storage or 

disposal. Do not contaminate 

water intended for irrigation or 

domestic purposes. 

Hops 15.9% SC/L Basal Spray 0.3459 lb NS 2 NS PHI= 28 

Treatment ae/A Days 

Foliar [ID87001500] 

[WA87001100] 

[OR87000400] 

Industrial 53% SC/L Water Treatment- 3.0-0.3 NS NS NS NS Do not discharge effluent 

Processing 

Water [4581-380] 

Metering Pump ppm 

endothall 

technical 

containing this pesticide into 

sewage systems without notifying 

the sewage treatment plant 

When Needed authority (POTW). Do not 

discharge effluent containing this 

product into lakes, streams, ponds, 

estuaries, oceans, or public water 

(NPDES license restriction). This 

pesticide is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. 

58
Site 

Application 

Timing 

Formulation 

[EPA Reg. 

No.] 

App. Type and 

Equipment 

Max. 

Single 

App. 

Rate 

(ae) 

Max. 

Number 

Apps. at 

Max. 

Rate 

Max. 

Number 

Apps. per 

Year/Crop 

Cycle 

Max. 

Seasonal 

Rate 

(ae) 

PHI, PGI, 

Prefeeding 

Interval 

Use Directions and Limitations 

Irrigation 

Systems 

When Needed 

53% RTU 

[AL81000900] 

[FL77000100] 

Surface TreatmentAerial, Boat 

Injection 

Equipment (max. 

11.2 lb ae/A-ft) 

15.2 lb 

ae/A-ft 

NS NS NS NS Apply to not more than 10 percent 

of surface area of water. 

53% SC/L 

[IN8000800] 

[AZ79001000] 

Water Treatment 0.2 ppm 

(L) 

NS 

53% SC/L 

[4581-174] 

[TX99000600] 

[1448-352] 

(max. 3.1536 

lb ae/A-ft) 

Injection 

Equipment, 

Sprayer 

13.51 lb 

ae/A-ft 

Do not use treated water for 

domestic purposes until 25 days 

after treatment. Do not use 

treated water for spraying or 

irrigation within 25 days after 

treatment. Do not use treated 

water for animal consumption 

within 25 days after treatment. 

Do not apply when drift is likely 

to occur. This product is toxic to 

fish. Do not contaminate water, 

food, or feed by storage or 

disposal. Do not use where fish 

are important resources. 

11.2% G 

[4581-172] 

Water TreatmentAerial, Ground 13.5 lb 

ae/A-ft 

Do not apply when drift is likely 

to occur. This product is toxic to 

fish. Do not contaminate water, 

food, or feed by storage or 

disposal. Do not contaminate 

water intended for irrigation or 

domestic purposes. 

59
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

Lakes/Ponds/ 53% RTU Surface Water 15.12 lb NS NS NS NS Apply to not more than 10 percent 

Reservoirs Treatment-Aerial, ae/A-ft of surface area of water. 

(With [FL77000100] Boat 

Human or [AL81000900] 

Wildlife Use) Injection 

Equipment (max. 

When Needed 11.2 lb ae/A-ft) 

53% SC/L Surface Water 8.008 lb Apply to not more than 10 percent 

[4581-174] 

Treatment-Sprayer ae/A-ft of surface water. Do not use 

treated water for domestic 

purposes until 25 days after 

treatment. Do not use treated 

water for spraying or irrigation 

within 25 days after treatment. 

Do not use treated water for 

animal consumption within 25 

days after treatment. Do not 

53% SC/L Surface/Subsurface 

Treatment-Sprayer, 

1.588 lb 

ae/A-ft 

[1448-352] Injection apply when drift is likely to occur. 

Equipment This product is toxic to fish. Do 

53% SC/L 6.807 lb not contaminate water, food, or

ae/A-ft feed by storage or disposal. Do 

[TX99000600] not use where fish are important 

resources. 

11.2% G 

[TX99000500] 

Water Treatmentby hand 162 lb/Aft (L) Buffer zone restriction (600 feet) 

on TX SLN. Do not contaminate 

water, food, or feed by storage or 

[4581-172] disposal. Do not apply when drift 

is likely to occur. This product is 

toxic to fish. Do not contaminate 

water intended for irrigation or 

domestic purposes. 

Potato 53% SC/L Aerial-Low 1.001 lb NS 1 NS PHI=14 Do not apply through any type or 

60
Site Formulation App. Type and Max. Max. Max. Max. PHI, PGI, Use Directions and Limitations 

Application [EPA Reg. Equipment Single Number Number Seasonal PreTiming No.] App. Apps. at Apps. per Rate feeding 

Rate Max. Year/Crop (ae) Interval 

(ae) Rate Cycle 

(White/Irish) Volume Spray ae/A Days irrigation system. Do not apply 

Foliar 

[4581-381] 

Ground-Spray 

directly to water, or to areas 

where surface water is present or 

to intertidal areas below the mean 

high water mark. Do not apply 

when drift is likely to occur. Do 

not contaminate water by cleaning 

of equipment or disposal of 

equipment wash waters. This 

product is toxic to fish. Do not 

contaminate water, food, or feed 

by storage or disposal. This 

pesticide is toxic to wildlife. Do 

not graze treated areas. Do not 

feed forage to dairy animals or 

animals being finished for 

slaughter. 

Swamps/Mar 11.2% G Water Treatment­ 162 lb NS NS NS NS Buffer zone restriction (600 feet). 

shes/Wetland Hand Application ae/A-ft Do not contaminate water, food, 

s/Stagnant [TX99000500] (L) or feed by storage or dis posal. 

Water 

When Needed 

61
62
B. Generic Data Requirements and Studies Used to Make the Reregistration Decision 

Guide to Appendix B 

Appendix B contains listing of data requirements which support the reregistration for active 

ingredients within case 2245 Endothall covered by this RED. It contains generic data requirements 

that apply to Endothall in all products, including data requirements for which a “typical formulation” 

is the test substance. 

The data table is organized in the following formats: 

1. Data Requirement (Column 1). The data requirements are listed in the order in which they appear 

in 40 CFR part 158. The reference numbers accompanying each test refer to the test protocols set in 

the Pesticide Assessment Guidance, which are available from the National technical Information 

Service, 5285 Port Royal Road, Springfield, VA 22161 (703) 487-4650. 

2. Use Pattern (Column 4). This column indicates the use patterns for which the data requirements 

apply. The following letter designations are used for the given use patterns. 

A. Terrestrial food 

B. Terrestrial feed 

C. Terrestrial non-food 

D. Aquatic food 

E. Aquatic non-food outdoor 

F. Aquatic non-food industrial 

G. Aquatic non-food residential 

H. Greenhouse food 

I. Greenhouse non-food 

J. Forestry 

K. Residential 

L. Indoor food 

M. Indoor non-food 

N. Indoor medical 

O. Indoor residential 

3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this column list 

the identify number of each study. This normally is the Master Record Identification (MRID) number, 

but may be a “GS” number if no MRID number has been assigned. Refer to the Bibliography 

appendix for a complete citation of the study. 

63
New Old Requirement Use Bibliographic Citation(s) 

Guideline Guideline Pattern 

Number Number 

PRODUCT CHEMISTRY 

830.1550 61-1 Product Identity and 

Composition 

A, B, E, 

F, G 

41616401 

830.1600 61-2 A Description of 

Starting Material 

A, B, E, 

F, G 

41616401, 43873901, 43873902 

830.1620 61-2 B Description of 

Production Process 

A, B, E, 

F, G 

41616401, 43873901, 43783902 

830.1670 61-2 B Discussion of A, B, E, 41616401, 43873901, 43873902 

Formation of F, G 

Impurities 

830.1700 62-1 Preliminary Analysis A, B, E, 

F, G 

41616402, 42427901, Data Gap for 4581-204, 

4581-174, 4581-380, 4581-381 

830.1750 62-2 Certified Limits A, B, E, 

F, G 

41616402 

830.1800 62-3 Enforcement of 

Analytical Method 

A, B, E, 

F, G 

41616402, 42427901 

830.6302 63-2 Color A, B, E, 

F, G 

42629701, 42629901, 42629801 

830.6303 63-3 Physical State A, B, E, 

F, G 

42629701, 42629901, 42629801 

830.6304 63-4 Odor A, B, E, 

F, G 

42629701, 42629901, 42629801 

830.6313 63-13 Stability A, B, E, 

F, G 

43265001, 43264901, 43265101, Data Gap for 

4581-174, 4581-380, 4581-381, 4581-204 

830.7000 63-12 pH A, B, E, 

F, G 

42629701, 42629901, 42629801 

830.7200 63-5 Melting Point A, B, E, 

F, G 

42629701, 42629901, Data Gap for 4581-174, 

4581-380, 4581-381 

830.7220 Boiling Point A, B, E, 

F, G 

Data Gap for 4581-174, 4581-380, 4581-381 

830.7300 63-7 Density A, B, E, 42629701, 42629901, 42629801 

F, G 

830.7550/ 

7560/757 

0 

63-11 Partition Coefficient A, B, E, 

F, G 

43472803, 43441501 

830.7370 63-10 Dissociation 

Constant 

A, B, E, 

F, G 

42668001, 42787702, 43081301 

830.7840/ 

7860 

63-8 Water Solubility A, B, E, 

F, G 

41622801, 43339301, 43551701, 43472802 

830.7950 63-9 Vapor Pressure A, B, E, 

F, G 

41622802, 43319601 

830.7050 None UV/Visible A, B, E, Data Gap for 4581-257, 4581-204, 4581-174, 

Absorption F, G 4581-380, 4581-381 

ECOLOGICAL EFFECTS 

64
New Old Requirement Use Bibliographic Citation(s) 

Guideline Guideline Pattern 

Number Number 

850.4100 122-1A Seedling Emergence A, B, E, 

F, G 

850.4150 122-1B Vegetative Vigor A, B, E, 

F, G 

850.4230 123-1 Early Seedling A, B, E, 

Growth Toxicity F, G 

850.2100 71-2 Avian Acute Dietary A, B, E, 43167701, 43167702, 43167801, 43167802, 

Toxicity F, G 43167901,43167902, 00035240, 00035241, 

00116270, 00116271, 00035238, 00035239 

850.2100 71-1 Avian Acute Oral A, B, E, 0160000, 42359501, 00035237, 42359701*, 

Toxicity F, G 00074220*, 42359601* 

850.2300 71-4 Avian Reproduction A, B, E, 

F, G 

42507301, 42507302*, Data Gap for N,Ndimethylalkylamine 

850.1075 72-1 Freshwater Fish A, B, E, 442327701, 42327702, 40098001, 40094602, 

Acute Toxicity F, G 00068507*, 114510*, 113971*, 43472801, 

00084149, 00084148, 0084147, 00007113, 

43196901, 00046269*, 00071148*00083025*, 

42695401, 42695402, 00071134* 

850.1010 72-2A Freshwater A, B, E, 42359702, 42695403, 00035242, 00074221, 

Invertebrate Acute F, G 00074222, 00074227*, 00074228*, 

Toxicity Test 43196902*, 05009242, 40098001, 00071137*, 

00115863*, 00017800*, 00084150*, 00084151 

850.1075 72-3 A Estuarine/Marine A, B, E, 42914102, 42695405, 43196903, 00074225, 

Fish Acute Toxicity F, G 44700401*, 00074226, 40098001 

Test 

Estuarine/Marine A, B, E, 00074223*, 0074224*, 42895201, 42914101, 

Invertebrate Acute F, G 43210001, 00035243, 00035244*, 43550201, 

Toxicity 42695406, 42695404 

850.1350 Estuarine/Marine Data Gap for N,N-dimethylalkylamine 

Invertebrate Early 

Life Stage Study 

850.1025 72-3B Estuarine/Marine 

Toxicity - Mollusk 

A, B, E, 

F, G 

42895201, 42695404, 43550201 

72-3C Estuarine/Marine A, B, E, 42914101, 42695046, 43210001 

Toxicity - Shrimp F, G 

850.1400 72-4A Freshwater Fish A, B, E, 43295401, 00095812, 43276501, Data Gap for 

Early Life-Stage F, G N,N-dimethylalkylamine 

Test 

850.1500 Freshwater Fish Life Data Gap for N,N-dimethylalkylamine 

Cycle Test 

72-4C Freshwater A, B, E, 43007801, 43437901 

Invertebrate Life- F, G 

Cycle Test 

850.1735 Freshwater Acute Data Gap for N,N-dimethylalkylamine 

Sediment Test 

850.1400 Estuarine/Marine Data Gap for N,N-dimethylalkylamine 

Acute Sediment Test 

65
New Old Requirement Use Bibliographic Citation(s) 

Guideline Guideline Pattern 

Number Number 

EPA/600/ Chronic Data Gap for N,N-dimethylalkylamine 

R01/020 Estuarine/Marine 

Sediment Testing 

EPA/600/ 65-day Test in Data Gap for N,N-dimethylalkylamine 

-99/064 Chironomous 

Tentans 

Non- Non- Acute Toxicity to 40098001 

Guideline Guideline Amphibians 

850.3020 141-1 Honey Bee Acute 

Contact Toxicity 

A, B, E, 

F, G 

44038201 

850.4400 122-2 Aquatic Plant 

Growth 

A, B, E, 

F, G 

41613809, 44392802 

850.4225 123-1A Seedling A, B, E, 42396405, 43870401, 44392803, 44127801 

Germination/ F, G 

Seedling Emergence 

(Tier II) 

850.4250 123-1B Vegetative Vigor 

(Tier II) 

A, B, E, 

F, G 

42396405, 43870401 

Aquatic Plant A, B, E, 41613809, 42396401*,42396402*, 42396404, 

Toxicity (Tier I) F, G 42396403*, 44392801, 44392802 

850.4400 123-2 Aquatic Plant 

Toxicity (Tier II) 

A, B, E, 

F, G 

42396406, 44949402, 44949203, 44127802*, 

44127803*, 44127805*, 44127804*, 

4427806*, 44976701, 44949202, 44949201, 

Acc. 244122*, 44408801 

OCCUPATIONAL/RESIDUE EXPOSURE 

875.1600 236 Application 44972201, 45250701 

Exposure 

Monitoring Data 

Reporting 

TOXICOLOGY 

870.1100 81-1 Acute Oral ToxicityRat A, B, E, 

F, G 

42289201 

N/A N/A Maximum Tolerated A, B, E, 40745201 

Oral Dose Toxicity ­ F, G 

Dog 

870.1200 81-2 Acute Dermal 

Toxicity-Rabbit/Rat 

A, B, E, 

F, G 

42289202 

870.1300 81-3 Acute Inhalation 

Toxicity-Rat 

A, B, E, 

F, G 

42169501, 42408701 

870.2400 81-4 Acute Eye Irritation 

- Rabbit 

A, B, E, 

F, G 

42289203 

870.2500 81-5 Acute Dermal 

Irritation 

A, B, E, 

F, G 

42289204 (unacceptable) 

870.2600 81-6 Dermal Sensitization A, B, E, 

F, G 

41871901 

66
New Old Requirement Use Bibliographic Citation(s) 

Guideline Guideline Pattern 

Number Number 

870.3100 82-1A 90-Day Feeding ­

Rodent 

A, B, E, 

F, G 

43480810 

870.3150 82-1B 90-Day Feeding -

Non-rodent 

A, B, E, 

F, G 

43480801, 43480802 

870.3200 82-2 21-Day Dermal -

Rabbit/Rat 

A, B, E, 

F, G 

42814101, 43465201 

870.3465 28-day Inhalation Data Gap 

870.4100 83-1B Chronic Feeding A, B, E, 40745202 

B Toxicity ­ Non- F, G 

Rodent 

870.3700 83-3A Prenatal A, B, E, 42776301 

Developmental F, G 

Toxicity - Rat 

870.4200 83-2B Oncogenicity ­

Mouse 

A, B, E, 

F, G 

40685301, 43608301 

870.3700 83-3B Developmental 

Toxicity - Rabbit 

A, B, E, 

F, G 

Data Gap 

870.3800 83-4 2-Generation 

Reproduction - Rat 

A, B, E, 

F, G 

43152101, 43629301 

870.4300 83-5 Combined Chronic A, B, E, 41040301 

Toxicity/ F, G 

Carcinogenicity 

870.5300 84-2 Gene Mutation (In 

vitro) 

A, B, E, 

F, G 

43437801 

870.5100 84-2 Bacterial Gene 

Mutation Assay 

A, B, E, 

F, G 

43154801 (unacceptable) 

870.5375 84-2B In vitro Mammalian 

Cytogenetics 

A, B, E, 

F, G 

41700302 

870.5395 84-2 In vivo Cytogenetics A, B, E, 43157401, 41700301 

- Micronucleus F, G 

Assay in Mice 

870.7485 85-1 Metabolism and 

pharmacokinetics 

A, B, E, 

F, G 

42169502, 44263501, 42200101 

870.7600 85-3 Dermal Penetration A, B, E, 

F, G 

42169503 

ENVIRONMENTAL FATE 

Dissociation - Non- A, B, E, 42668008, 43551501, 43081301 

guideline F, G 

NONE 201-1 Droplet Size 

Spectrum 

A, B, E, 

F, G 

42427601 

835.2120 161-1 Hydrolysis A, B, E, 

F, G 

44578401, 42289106 

835.4100 162-1 Aerobic Soil 

Metabolism 

A, B, E, 

F, G 

44949401 

835.4400 162-3 Anaerobic Aquatic 

Metabolism 

A, B, E, 

F, G 

42903901 

67
New 

Guideline 

Number 

Old 

Guideline 

Number 

Requirement Use 

Pattern 

Bibliographic Citation(s) 

835.4300 162-4 Aerobic Aquatic 

Metabolism 

A, B, E, 

F, G 

42618901 

835.2240 161-2 Aqueous Photolysis A, B, E, 

F, G 

42289205, 42289205, 42289205, 42641201, 

Acc 259367 

835.1230 163-1 Sediment and Soil 

Adsorption/ 

Desorption for 

Parent and 

Degradates 

A, B, E, 

F, G 

41616404 

835.6100 164-1 Terrestrial 

Dissipation 

A, B, E, 

F, G 

42670101, 42670201 

835.6200 164-2 Aquatic Field 

Dissipation 

A, B, E, 

F, G 

44093403, 44093402, 44820103, 44828802, 

44828801, 44820101 

NONE 165-4 Bioconcentration in 

Fish 

A, B, E, 

F, G 

42644001, 43315801 

RESIDUE CHEMISTRY 

860.1300 171-4A Nature of Residue ­

Plants 

A, B, E, 

F, G 

00040978, 00108102, 00113954, 00113965, 

42619201, 42619202, 42619203, 43346601, 

44077801 

860.1300 171-4B Nature of Residues ­

Animals 

A, B, E, 

F, G 

00035451, 00035452, 00113928, 00113963, 

00133190, 42792701, 42816601 

860.1340 171-4C Residue Analytical 

Method -Plants 

A, B, E, 

F, G 

45156001, 44320401, 44320402, 44320403, 

44322001, 44322002, Data Gap for conversion 

of monomethyl ester to endothall 

860.1340 171-4D Residue Analytical 

Method-Animal 

A, B, E, 

F, G 

45156001, Data Gap for conversion of 

monomethyl ester to endothall 

Data collection and regulatory analytical 

methods are needed for the determination 

of endothall, per se, in animal 

commodities 

860.1340 Independent 

Laboratory 

Validation 

A, B, E, 

F, G 

Submission of analytic reference 

standards for dipotassium and monoN,N-dimethylalkylamine salts of 

endothall are needed 

860.1360 171-4M Multi-residue 

Method 

A, B, E, 

F, G 

44608601 

860.1850 165-1 Confined Rotational 

Crop 

43300701, Data Gap 

860.1340 Data Gap - Independent Laboratory Validation 

(ILV) of an enforcement method for the 

determination of endothall and its monomethyl 

ester in fish is needed to support proposed 

tolerances on fish. 

68
New Old Requirement Use Bibliographic Citation(s) 

Guideline Guideline Pattern 

Number Number 

860.1380 171-4E Storage Stability A, B 

A, B, E, 

F, G 

43975901, 44077801, 44106301, 44263502, 

44263503, 44263504, 44263505, 44274401, 

45146302, Data Gap for additional studies on 

processed plant commodities, animal 

commodities, and fish. 

44343101, 44263506, 44334301, 44263508, 

860.1400 171-4H Magnitude of A, B, E, 44263507, Data Gap 

Residue in Irrigated F, G 

Crops 

Data Gap 

860.1480 171-4J Magnitudes of 

residues in Meat, 

Milk, Poultry, Eggs 

A, B, E, 

F, G 

Milk and the Fat, 

Meat, and Meat 

Byproducts of 

Cattle, Goats, Hogs, 

Horses and Sheep 

Eggs and the Fat, 

Meat, and Meat 

Byproducts of 

Poultry 

860.1400 171-4G Magnitude of 

Residues in Fish 

A, B, E, 

F, G 

44820102, 43315801 

Data Gap 

860.1650 171-13 Analytical Reference A, B, E, 

Standards F, G 

860.1500 

171-4K Crop Field Trials A, B 43953101, 45146301, 43975901, 44103701, 

44037402, 45034701, 43953101 

44093401, 44012101, 45146302, 44037401, 

860.1520 171-4L Processed Food/Feed A, B, Data Gap (potato, alfalfa seed, cottonseed, and 

cotton gin products, apples, field corn, grapes, 

orange, rice, sorghum, soybeans, sugar beet, 

tomato, and wheat) 

69
C. Technical Support Documents

Additional documentation in support of this RED is maintained in the OPP 

Regulatory Docket, located in Room 119, Crystal Mall #2, 1801 South Bell Street, 

Arlington, VA 22202-4501. It is open Monday through Friday, excluding legal holidays, 

from 8:30 am to 4:00 pm. 

The docket initially contained preliminary human health and ecological effects 

risk assessments and related documents that were published May 11, 2005. The public 

comment period closed sixty (60) days later on July 11, 2005. The EPA then considered 

comments and revised the risk assessments where appropriate. Final human health and 

ecological risk assessments, as well as additional support documents, will be pub lished in 

the docket with this RED. These documents include: 

Phase 3 Public Comment Documents: 

1. Environmental Fate and Ecological Risk Assessment for Endothall-Revised, dated 

April 22, 2005 

2. Environmental Fate and Effects Division Error-Only Corrections of the Endothall 

RED, dated April 22, 2005 

3. Endothall: HED Chapter for the Reregistration Eligibility Decision Document (RED), 

dated April 18, 2005 

4. Endothall- Report of the Hazard Identification Assessment Review Committee, dated 

June 14, 2004 

5. Endothall-Report of the Health Effects Division (HED) Risk Assessment Review 

Committee (RARC), dated November 4, 2004 

6. Drinking Water Assessment for Endothall for both Terrestrial and Aquatic Uses, dated 

May 5, 2004 

7. Endothall and its salts: Chronic Dietary Exposure Assessment for the Reregistration 

Eligibility Decision. Revised per Registrant Corrections, dated April 11, 2005 

8. Endothall and its salts: Residue Chemistry Considerations for Reregistration Eligibility 

Decision. Revised per Regis trant Comment for Error Only, dated April 11, 2005 

9. Revised Occupational and Residential Exposure Assessment and Recommendations 

for the Reregistration Eligibility Decision Document for Endothall, dated April 1, 2005 

70
2005 

10. Occupational and Residential Exposure Assessment-Response to Registrant's ErrorOnly Comments, dated March 18, 2005 

11. Endothall and Salts: Occupational and Residential Exposure Assessment of 

Antimicrobial Uses for the Reregistration Eligibility Decision, dated March 3, 2005 

12. Ecological Risk from Antimicrobial Uses of Endothall to be Considered in the RED 

Document, dated January 12, 2005 

13. Review of Endothall (and salts) Incident Reports, dated June 24, 2005

Final Risk Assessments and Additional Supporting Documents: 

1. Endothall: HED Chapter of the Reregistration Eligibility Decision Document (RED). 

Corrected Following Pub lic Comments, dated September 30, 2005 

2. Endothall: HED Response to Public Comments, dated August 26, 2005

3. Environmental Fate and Effects Division Response to Public Comment for the 

Endothall RED, dated August 6, 2005 

4. Revised Occupational and Residential Exposure Assessment and Recommendations 

for the Reregistration Eligibility Decision Document for Endothall, dated August 12, 

5. Amended Response to a Submitted Dietary Exposure Assessment and a Comment on 

Fish Consumption in the US, dated July 25, 2005 

6. Response to the Four Residue Chemistry Comments from Cerexagri in their "Response 

to the EPA's RED Comments for Endothall," dated August 30, 2005 

7. Endothall and its Salts. Residue Chemistry Considerations for Reregistration Eligibility 

Decision. Revised per Registrant Comments, dated August 30, 2005 

8. Endothall: Toxicology Disciplinary Chapter for the Reregistration Eligibility Decision 

Document (RED), dated December 21, 2004 

9. Endothall, Acute Mammalian Toxicity Batching Appendix for Endothall RED 

Document, dated September 21, 2005 

10. Meeting with Army Corp of Engineers, Meeting Minutes, dated July 27, 2005

11. Revised Endothall and Salts: Occupational and Residential Exposure Assessment of 

Antimicrobial Uses for the Reregistration Eligibility Decision Document, dated 

September 28, 2005 

71
12. Addendum to Chronic Dietary Risk Assessment, dated September 29, 2005 

13. Closure Call Meeting Minutes, dated September 26, 2005 

14. Addendum to Drinking Water Assessment, dated September 29, 2005

72
D. Bibliography

GUIDE TO APPENDIX D 

1. CONTENTS OF BIBLIOGRAPHY. This bibliography contains citations of all 

studies considered relevant by EPA in arriving at the positions and conclusions stated 

elsewhere in the Reregistration Eligibility Document. Primary sources for studies in this 

bibliography have been the body of data submitted to EPA and its predecessor agencies 

in support of past regulatory decisions. Selections from other sources including the 

published literature, in those instances where they have been considered, are included. 

2. UNITS OF ENTRY. The unit of entry in this bibliography is called a “study.” In 

the case of published materials, this corresponds closely to an article. In the case of 

unpublished materials submitted to the Agency, the Agency has sought to identify 

documents at a level parallel to the published article from within the typically larger 

volumes in which they were submitted. The resulting “studies” generally have a distinct 

title (or at least a single subject), can stand alone for purposes of review and can be 

described with a conventional bibliographic citation. The Agency has also attempted to 

unite basic documents and commentaries upon them, treating them as a single study. 

3. IDENTIFICATION OF ENTRIES. The entries in this bibliography are sorted 

numerically by Master Record Identifier, or “MRID” number. This number is unique to 

the citation, and should be used whenever a specific reference is required. It is not 

related to the six-digit “Accession Number” which has been used to identify volumes of 

submitted studies (see paragraph 4(d)(4) below for further explanation). In a few cases, 

entries added to the bibliography late in the review may be preceded by a nine character 

temporary identifier. These entries are listed after all MRID entries. This temporary 

identifying number is also to be used whenever specific reference is needed. 

4. FORM OF ENTRY. In addition to the Master Record Identifier (MRID), each 

entry consists of a citation containing standard elements followed, in the case of material 

submitted to EPA, by a description of the earliest known submission. Bibliographic 

conventions used reflect the standard of the American National Standards Institute 

(ANSI), expanded to provide for certain special needs. 

a. Author. Whenever the author could confidently be identified, the Agency 

has chosen to show a personal author. When no individual was identified, the Agency 

has shown an identifiable laboratory or testing facility as the author. When no author or 

laboratory could be identified, the Agency has shown the first submitter as the author. 

b. Document date. The date of the study is taken directly from the 

document. When the date is followed by a question mark, the bibliographer has deduced 

the date from the evidence contained in the document. When the date appears as (1999), 

the Agency was unable to determine or estimate the date of the document. 

73
c. Title. In some cases, it has been necessary for the Agency bibliographers 

to create or enhance a document title. Any such editorial insertions are contained 

between square brackets. 

d. Trailing parentheses. For studies submitted to the Agency in the past, the 

trailing parentheses include (in addition to any self-explanatory text) the following 

elements describing the earliest known submission: 

(1) Submission date. The date of the earliest known submission appears immediately 

following the word “received.” 

(2) Administrative number. The next element immediately following the word 

“under” is the registration number, experimental use permit number, petition number, or 

other administrative number associated with the earliest known submission. 

(3) Submitter. The third element is the submitter. When authorship is defaulted to 

the submitter, this element is omitted. 

(4) Volume Identification (Accession Numbers). The final element in the 

trailing parent heses identifies the EPA accession number of the volume in 

which the original submission of the study appears. The six-digit 

accession number follows the symbol “CDL,” which stands for “Company 

Data Library.” This accession number is in turn followed by an alphabetic 

suffix which shows the relative position of the study within the volume. 

74
Bibliography Citations for Endothall Acid 

MRID Citation Receipt 

Date 

4459 

Wright, W.G. (1966) Summary of 1966 Weed Control Trials. (Unpublished study 

received Nov 6, 1967 under 464-398; prepared by South Dakota State Univ., Dept. of 

Agronomy, submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:003622-C) 

06-Nov1967 

Hamson, A.R. (1954) News and Views about New York's Second Most Important 

Agricultural Industry: Dry Bean Defoliation. (Cornell VegNews 5(7):1-3; unpublished 

4573 study including letter dated Sep 13, 1954 from A.R. Hamson to unknown recipient, 

received Jul 28, 1960 under 359-400; prepared by Cornell Univ., New York State 

28-Jul1960 

Agricultural Experiment Station, Dept. of Vegetable Crops, submitted by Rhone-Poulenc, 

Inc., Monmouth Junction, N.J.; CDL:023310-F) 

Welker, W.V.; Holm, L.G. (19) Pre-Emergence Herbicide Treatments on Red Beets. 

9984 

(Unpublished study received Dec 23, 1957 under 524-96; prepared by Univ. of 

Wisconsin, Agricultural Experiment Station, Dept. of Horticulture, submitted by 

Monsanto Co., St. Louis, Mo.; CDL:223118-Y) 

23-Dec1957 

15941 E.I. du Pont de Nemours & Company (1954) Spinach Weed Control. (Unpublished study 

received Jun 14, 1955 under 352-197; CDL: 002773-G) 

14-Jun1955 

19227 

Counselman, C.J.; Kincaid, L.R.; Geary, R.J.; et al. (19) Herbicidal Activity of 

Chloroxuron (N-4(~p~-Chlorophenoxy)-phenyl- N',N'-dimethylurea) and C-2059 (N-3-

Trifluoromethylphenyl)-N', N'-dimethylurea) in Seven Areas of the United States. 

(Unpublished study received Jun 29, 1964 under unknown admin. no.; submitted by Ciba 

Agrochemical Co., Summit, N.J.; CDL:127559-B) 

29-Jun1964 

08-Oct1964 

11-May1965 

Grehlinger, P.M.; Johnson, R.; Messinger, D.; et al. (1970) Summary of Tandex Efficacy 

20211 Data--Ragweed. (Unpublished study received Apr 17, 1972 under 279-2717; prepared in 

cooperation with Amchem and others, submitted by FMC Corp., Philadelphia, Pa.; CDL: 

17-Apr1972 

002491-B) 

22290 

Lyle, M.; Walter, G. (1974) Eptam 10 G Fall Application on Sugar- beets: Crop 

Tolerance and Weed Control Summary. (Unpublished study received Feb 20, 1976 under 

476-1620; submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:223820-D) 

20-Feb1976 

22917 

University of Nebraska, Department of Agronomy (1961) Weed Control in Castorbeans 

in Nebraska in 1961. (Unpublished study received Mar 18, 1965 under 400-46; submitted 

by Uniroyal Chemical, Beth- any, Conn.; CDL:003233-B) 

18-Mar1965 

Collins, H.A.; Kincaid, L.R.; Colby, C.M. et al. (1978) Biological Research Report on 

23939 Herbicide Efficacy. (Unpublished study received Jan 11, 1978 under 100-437; prepared in 

cooperation with Missouri, Dept. of Conservation and others, submitted by Ciba-Geigy 

11-Jan1978 

Corp., Greensboro, N.C.; CDL:232638-A) 

Sutton, D.L.; Evrard, T.O.; Chappell, W.E. (1959) Weed Control Studies in Farm Ponds 

24085 Using Simazine and Other Herbicides. (Unpublished study received Apr 29, 1965 under 

100-437; prepared by Virginia Polytechnic Institute, Agricultural Experiment Sta- tion, 

29-Apr1965 

submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL: 000232-A) 

Gallagher, J.E.; Otten, R.J. (1963) Weed Control in Bermuda and Zoysia Grasses. 

24094 (Unpublished study received Dec 19, 1963 under 264-156; prepared in cooperation with 

Amchem Products, Inc., submitted by Union Carbide Agricultural Products Co., Ambler, 

19-Dec1963 

Pa.; CDL:002123-A) 

75
Timmons; Weldon; Lee; et al. (1959) Herbicides to Control Weeds. (Unpublished study 20-Nov24109 received Nov 20, 1959 under 264-119; prepared in cooperation with U.S. Fish and 

Wildlife Service and Delaware, Board of Game and Fish Commissioners, submitted by 

1959 

03-DecUnion Carbide Agricultural Products Co., Ambler, Pa.; CDL: 001891-F) 1959 

Davis, H.C.; Hidu, H. (19) Effects of pesticides on embryonic development of Clams and 

25816 Oysters and on survival and growth of the Larvae. Fishery Bulletin 67(2):393-400,403. 

(also in unpublished submission received Jan 2, 1980 under 2217-485; submitted by PBI02-Jan1980 

Gordon Corp., Kansas City, Kans.; CDL:241581-W) 

26244 Miller, C.W.; Lowe, J.I. (19) Toxicity of Herbicides to Estuarine Animals. (U.S. Bureau 

of Commercial Fisheries, unpublished report.) 

05-Jan1968 

Washington State University, Agricultural Extension Service (1965) Washington State 

27000 

Weed Control Recommendations for Central and Eastern Washington: Weed Control in 

Seed. Rev. Pullman, Wash.: WSU, AES. (E.M. 2179; pp. 52 -53 only; also in unpublished 

submission received Oct 2, 1967 under 8F0643; submitted by Stauffer Chemical Co., 

02-Oct1967 

Richmond, Calif.; CDL:091116-AP) 

Walker, C.R. (1966) Aquatic Weed Control. (Summary of unpublished paper presented at 

28032 

the 23rd Annual North Central Weed Control Conference; 1966; unpublished study 

received may 28, 1968 under 352-247; prepared by Illinois, Natural History Survey and 

U.S. Fish and Wildlife Service, submitted by E.I. du Pont de Nemours & Co., 

28-May1968 

Wilmington, Del.; CDL:002855-G) 

Fults, J.; Blouch, R.; Thornton, B. (1952) Summary of Data Relative to use of Karmex W 

28065 Herbicide and Karmex DW Herbicide on Potatoes. (Unpublished study received Feb 4, 

1956 under PP0062; submitted by E.I. du Pont de Nemours & Co., Wilmington, Del.; 

04-Feb1956 

CDL:090060-B) 

Frank, P.A. (1971) Evaluation of Aquatic Herbicides. (Unpublished paper prepared for 

28441 

the Weed Science Society meeting; Feb 3 -5, 1970, Montreal, Canada; unpublished study 

received Jul 13, 1971 under 1E1046; prepared by U.S. Agricultural Research Service, 

Crops Protection Branch, submitted by U.S. Dept. of the Army, Office of the Chief of 

13-Jul1971 

Engineers, Washington, D.C.; CDL: 091865-C) 

29786 

Sibbald, J.H. (1968) Test Report: MSMA as a Silvicide. (Unpublished study received Dec 

4, 1968 under 6308-58; submitted by Ansul Chemical Co., Weslaco, Tex.; CDL:007869-

A) 

04-Dec1968 

Chisholm, K.W.; Ekins, W.L. (1979) Nortron EC + Betanex and/or Bet- anal 

31570 Postemergence EUP Program for 1978 and 1979: Efficacy and Crop Safety Data. 

(Unpublished study received Jan 2, 1980 under 10065-EX-4; submitted by Fisons Corp., 

02-Jan1980 

Agricultural Chemicals Div., Bedford, Mass.; CDL:241688-A) 

Blackburn, R.D.; Weldon, L.W. (1964) Control of Southern Naiad in Florida drainage 

31855 and irrigation channels. Weeds 12(4):295-298. (also in unpublished submission received 

Sep 15, 1972 under 1F1101; submitted by Chevron Chemical Co., Richmond, Calif.; 

15-Sep1972 

CDL:090862-AE) 

Younger, V.B. (1958) Kikuyugrass, Pennisetum clandestinum, and its control. Southern 

32062 California Turfgrass Culture 8(1):1-2. (also in unpublished submission received Feb 20, 

1959 under 464-164; submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:022959-

20-Feb1959 

A) 

Stewart, D.; Nelson, R.T.; Laumeister, L.T.; et al. (1961) Weed Control in Plants. 

32563 (Unpublished study including published data, received Feb 14, 1961 under 4581-79; 

prepared in cooperation with U.S. Agricultural Research Service, Field Crops Re- search 

14-Feb1961 

Branch, Sugar Crops Section and others, submitted by Pennwalt Corp., Agchem Div., 

76
King of Prussia, Pa.; CDL:007437-A) 

Stroube, E.W.; Zielke, R.C.; Nylund, R.E.; et al. (1964) Efficacy Study. (Unpublished 

33985 study received Nov 25, 1964 under 4581- 234; prepared in cooperation with Ohio State 

Univ., Agricultural Experiment Station and others, submitted by Pennwalt Corp., 

25-Nov1964 

Agchem Div., King of Prussia, Pa.; CDL:026043 -A) 

34138 Union Carbide Agricultural Products Company (1958) Clover Control with 2,4,5-TP. 

(Unpublished study received Jul 9, 1958 under 264-76; CDL:001871-A) 

09-Jul1958 

Fink, R. (1975) Final Report: Eight-Day Dietary LCI50--Mallard Ducks: Project No. 110­

35233 106. (Unpublished study received Oct 21, 1975 under 4581-EX-18; prepared by Truslow 

Farms, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 

21-Oct1975 

096340-B) 

Keckemet, O. (1975) Substantive Amendment to Pesticide Petition No. 3F1416 (Also 

35234 

Designated as Pesticide Petition No. 4G1449- Temporary Tolerance and Temporary 

Permits 4581-EXP-18G and 4581- EXP-21G). (Unpublished study received Oct 21, 1975 

under 4581- EX-18; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

21-Oct1975 

CDL:096340-C) 

35236 Pennwalt Corporation (1975) Fish and Wildlife Safety. (Unpublished study received Jan 

5, 1978 under 1F1105; CDL:096705-A) 

05-Jan1978 

35245 Pennwalt Corporation (1970) Beneficial Insect Safety. (Unpublished study received Jan 

5, 1978 under 1F1105; CDL:096705-K) 

05-Jan1978 

35249 Pennwalt Corporation (1952) Accident Exposure Experience: (Endothall). (Unpublished 

study received Jan 5, 1978 under 1F1105; CDL:096705-L) 

05-Jan1978 

35405 

Syracuse University Research Corporation (1969) Fate of Herbicides in the Aquatic 

Environment. (In cooperation with New York State, Conservation Dept., unpublished 

study; CDL:091753 -F) 

27-Nov1973 

35427 Pennwalt Corporation Product Chemistry: Data Requirements. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL: 096703-A) 

05-Jan1978 

35428 Pennwalt Corporation (1977) Quality Control Specifications for Furan. (Unpublished 

study received Jan 5, 1978 under 1F1105; CDL:096703-B) 

05-Jan1978 

35429 Pennwalt Corporation (1962) Analysis of Endothall acid, PF-3441. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL: 096703-C) 

05-Jan1978 

35430 

Pennwalt Corporation (1976) Analytical Procedure for Endothall Technical. Method 

dated Apr 1976. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-

D) 

05-Jan1978 

35432 

Whitaker, R.L. (1977) Product Stability. (Unpublished study received Jan 5, 1978 under 

1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096703-

G) 

05-Jan1978 

35434 Pennwalt Corporation (19) Product Chemistry: Data Requirements. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL: 096703-I) 

05-Jan1978 

Pennwalt Corporation (1970) A Rapid Method for the Determination of Primary, 

Secondary and Tertiary Aliphatic Amines in Mixtures. Calculation of Neutralization 

35435 Equivalents and Amine Numbers. Method A-26 dated Mar 23, 1970. (Unpublished study 

including letters dated Dec 2, 1976 from W. Whitla to Harold Lindaberry and Jun 2, 1977 

05-Jan1978 

from L.D. Metcalfe to Harold Linda- berry, received Jan 5, 1978 under 1F1105; 

CDL:096703-L) 

77
Pennwalt Corporation (1976) Analytical Procedure for Hydrothol(R) 191 Liquid, 

35436 Hydrothol 191 Granular (Hydrothol 191 Rice Herbicide), and Herbicide 283. Method 

dated Apr 1976. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-

05-Jan1978 

M) 

35439 Pennwalt Corporation (1975) Residue Chemistry: I. Summary. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL:096703-P) 

05-Jan1978 

35440 

Pennwalt Corporation (1975) Analytical Method for Residues of Endothall in Various 

Crops and Other Materials. Method dated May 1975. (Unpublished study received Jan 5, 

1978 under 1F1105; CDL:096703-Q) 

05-Jan1978 

35441 Pennwalt Corporation (19) Storage Stability of Endothall Residues. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL:096703-R) 

05-Jan1978 

35442 

Pennwalt Corporation (1974) Results of Residue Determinations: Disappearance of 

Endothall in Water. (Unpublished study received Jan 5, 1978 under 1F1105; 

CDL:096703-S) 

05-Jan1978 

35444 Pennwalt Corporation (1975) Results of Residue Determinations: Residues in Irrigated 

Crops. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-U) 

05-Jan1978 

35445 Pennwalt Corporation (1977) Results of Residue Determinations: Animals (Meat, Milk, 

and Eggs). (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-V) 

05-Jan1978 

35446 

Pennwalt Corporation (1972) Metabolism and Fate of Endothall: Aquatic Environment 

(Water, Aquatic Plants, and Hydrosoil). (Unpublished study received Jan 5, 1978 under 

1F1105; CDL: 096703-W) 

05-Jan1978 

35447 Pennwalt Corporation (1960) Metabolism and Fate of Endothall: Fish. (Unpublished 

study received Jan 5, 1978 under 1F1105; CDL:096703-X) 

05-Jan1978 

35448 Pennwalt Corporation (1975) Metabolism and Fate of Endothall: Crops. (Unpublished 

study received Jan 5, 1978 under 1F1105; CDL:096703-Y) 

05-Jan1978 

35449 Pennwalt Corporation Metabolism and Fate of Endothall: Animals. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL:096703-Z) 

05-Jan1978 

35450 Pennwalt Corporation Metabolism and Fate of Endothall: Soils. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL:096703-AA) 

05-Jan1978 

35451 

Pennwalt Corporation (1976) A Further Characterization of 14C Activity Resulting in 

Goats Milk after Feeding 14C Endothall. (Unpublished study received Jan 5, 1978 under 

1F1105; CDL: 096703-AB) 

05-Jan1978 

Smith, K.S. (1976) 14C-Endothall Feeding Study in Lactating Goats: Laboratory No. 6E35452 2214. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL: 096703-AC) 

35453 Pennwalt Corporation (1954) Toxicology Endothall. (Unpublished study received Jan 5, 

1978 under 1F1105; CDL:096703-AE) 

05-Jan1978 

35454 Pennwalt Corporation Analytical Method, Residues, and Metabolites. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL:096703-AF) 

05-Jan1978 

35455 Pennwalt Corporation Fate and Persistence in the Environment. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL:096703-AG) 

05-Jan1978 

35456 Pennwalt Corporation (1952) Safety to Manufacturer, Applicator, and User. (Unpublished 

study received Jan 5, 1978 under 1F1105; CDL:096703-AH) 

05-Jan1978 

78
35457 Pennwalt Corporation (1963) Reasonable Grounds in Support of the Petition: Summary: 

Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-AD) 

05-Jan1978 

Pennwalt Corporation (1976) Analytical Procedure for Aquathol(R) (Endothal Turf 

35892 Herbicide and Endothal Weed Killer), Aquathol K, Herbicide 273 and Aquathol 

Granular. Method dated Apr, 1976. (Unpublished study received Jan 5, 1978 under 

05-Jan1978 

1F1105; CDL: 096703-F) 

36528 

Pennwalt Corporation (1975) Environmental Chemistry: Conclusions. Summary of 

studies 096704-B, 096704-D through 096704-G, 096704-L and 096704-M. (Unpublished 

study received Jan 5, 1978 under 1F1105; CDL:096704-A) 

05-Jan1978 

36529 

Carlson, R.E.; Sandeno, J.L. (1970) Effect of Endothall on the Growth of Several Fungi. 

(Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp ., 

Agchem Div., King of Prussia, Pa.; CDL:096704 -B) 

05-Jan1978 

Watson, J.D.; Isensee, A.R. (1972) The Results of Tests on the Amount of Residue 

Remaining, Including a Description of the Analytical Method Used: (Endothall). 

36538 (Unpublished study received Jan 5, 1978 under 1F1105; prepared in cooperation with 

U.S. Agricultural Research Service, Plant Science Div., Crop Protection Research 

05-Jan1978 

Branch, Pesticide Investigations--Behavior in Soils, submitted by Pennwalt Corp., 

Agchem Div., King of Prussia, Pa.; CDL:096704-M) 

36540 

Pennwalt Corporation (1977) Human Safety: Summary of Toxicity Data. Summary of 

studies 096704-D through 096704-J, 096704-M and 096704 -BV through 096704-BY. 

(Unpublished study received Jan 5, 1978 under 1F1105; CDL:096707-O) 

05-Jan1978 

36541 

Latven, A.R. (1975) Endothall Technical (N.B. 58-196-2). (Unpublished study received 

Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by 

Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-Q) 

05-Jan1978 

Latven, A.R. (1975) Ripenthol N.B. 58-188-3 (Isopropyl-butanol Formulation). 

36547 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology 

Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-Y) 

36548 

Latven, A.R. (1975) Ripenthol N.B. 58-191-2 (Water Only Formula- tion). (Unpublished 

study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., 

submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-Z) 

05-Jan1978 

Stevens, K.R. (1976) Teratologic Evaluation of Endothal in Rats: Laboratory No. 5129. 

36593 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Food and Drug 

Research Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, 

05-Jan1978 

Pa.; CDL:096704-BV) 

Latven, A.R. (1975) Ripenthol N.B. 58-191-2 (23.4%). (Unpublished study including 

36597 letter dated Aug 14, 1975 from A.R. Latven to Obren Kechemet, received Jan 5, 1978 

under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 

05-Jan1978 

Agchem Div., King of Prussia, Pa.; CDL:096704 -CA) 

37355 Walsh, G.E. (1970) Effects of Pesticides: Report No. 2-119a. (U.S. Fish and Wildlife 

Service, Bureau of Commercial Fisheries, un- published study; CDL:091902-R) 

03-Sep1971 

Brimhall, P.B. (1969) 1969 Herbicide Report. (Unpublished study including letter dated 

37773 Dec 19, 1969 from P.B. Brimhall to Barry Regan, received May 1, 1971 under 1F1165; 

prepared by Northern Ohio Sugar Co., submitted by Dow Chemical U.S.A., Midland, 

01-May1971 

Mich.; CDL:090959-F) 

38629 Surber, E.W.; Pickering, Q.H. (1962) Acute toxicity of Endothal, Diquat, Hyamine, 

Dalapon, and Silvex to fish. Progressive Fish-Culturist (Oct):164-171. (U.S. Public 

01-Jan1962 

79
Health Service, Robert A. Taft Sanitary Engineering Center, published study; 18-MarCDL:095428-F) 1976 

Scott, R.A., Jr.; Gangstad, E.O. (1970) Technical Report of Monitoring Guidelines for 

Use--Registration of Herbicides in Quiescent Aquatic Sites: AD882977. Includes undated 

methods en- titled: Extraction of Butoxyethanol ester of 2,-4D from water and analysis by 

gas chromatography; Extraction of 2,4-D acid, amines, and mineral salts from water and 

38630 analysis by gas chromatography; Extraction of Isooctyl and PGBE ester of Phenoxy acid 

herbicides from water and analysis by gas chromatography; Extraction of Dichlobenil 

13-Jun1975 

from water and analysis by gas chromatography; Analytical method for residues of 

Endothall in water. (Unpublished study received Jun 13, 1975 under 5E1648; prepared by 

U.S. Dept. of the Army, Office of the Chief of Engineers and Pennwalt Corp., submitted 

by Chevron Chemical Co., Richmond, Calif.; CDL:095428-H) 

Blackburn, R.D.; Gangstad, E.O. (1970) Efficacy and Residues of Diquat Applied for 

38631 Control of Egeria and Hydrilla. (Unpublished study received Jun 13, 1975 under 5E1648; 

prepared by U.S. Agricultural Research Service, Florida/Antilles Area and others, 

13-Jun1975 

submitted by Chevron Chemical Co., Richmond, Calif.; CDL:095428-I) 

Schreck, C.B.; Berry, C.R.; Strange, R.J.; et al. (1974) Ecosystem Studies on the Use of 

Diquat and Endothal for Aquatic Plant Con- trol in a Large Potable Water Supply 

38643 

Reservoir: Contract No. DAW-65-74-C-0013. (Virginia, Commission of Game and 

Inland Fisheries and Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and 

Wildlife Sciences for U.S. Dept. of the Army, Office of the Chief of Engineers, Aquatic 

13-Jun1975 

Plant Control Program, Interagency Technical Advisory Committee, unpublished study; 

CDL:095428-Y) 

Strange, R.J. (1975) The Effects of Herbicides on Primary Productivity, Phytoplankton 

38644 Dynamics, and Water Chemistry of an Aquatic System. Master's thesis, Virginia 

Polytechnic Institute and State Univ. (Unpublished study received Jun 13, 1975 under 

13-Jun1975 

5E1648; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:095428-Z) 

Van Horn, S.L. (1975) Dissipation of the Herbicides Endothall, Diquat, and a 1:1 Mixture 

38645 in Water, Sediment, and Egeria densa. Master's thesis, Virginia Polytechnic Institute and 

State Univ. (Unpublished study received Jun 13, 1975 under 5E1648; submitted by 

13-Jun1975 

Chevron Chemical Co., Richmond, Calif.; CDL:095428-AA) 

MacEwen, J.D. (1963) Toxicity Studies on Endothal acid: Development File No. 342.44- 10-Apr40960 11/1. (Unpublished study received Apr 10, 1966 under 6G0503; prepared by Wayne State 

Univ., Dept. of Industrial Medicine and Hygiene, submitted by Pennsalt Chemical Corp., 

1966 

14-AprBryan, Tex.; CDL:090587-C) 1966 

40962 

Brieger, H. (1953) Endothal Short-Term Oral Toxicity Test: Dogs. (Unpublished study 

received Apr 10, 1966 under 6G0503; prepared by Jefferson Medical College, submitted 

by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-E) 

10-Apr1966 

14-Apr1966 

40966 Pennsalt Chemical Corporation (19) Residue Studies on Cotton- seed. (Unpublished 

study received Apr 10, 1966 under 6G0503; CDL:090587-I) 

10-Apr1966 

40971 

Lee, W.M.; Munter, P.A. (1953) Endothal--Residue Analysis --Progress Report. 

(Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt 

Chemical Corp., Bryan, Tex.; CDL:090587-O) 

10-Apr1966 

40972 

Lee, W.M.; Lyons, H. (1953) Endothal--Residue Analysis --Progress Report. 

(Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt 

Chemical Corp., Bryan, Tex., CDL:090587-P) 

10-Apr1966 

40973 Massengale, J.T. (1952) Bioassay of Endothal Residues. (Unpublished study received 10-Apr80
Apr 10, 1966 under 6G0505; submitted by Pennsalt Chemical Corp., Bryan, Tex.; 1966 

CDL:090587-Q) 

Carlson, R.E. (1966) Bioassy of Endothal. Undated method. (Unpublished study received 10-Apr- 40975 Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex., 1966 CDL:090587-S) 

Munter, P.A. (1954) Determination of Endothal Residues in Plant Material. Undated 

40976 method. (Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt 10-Apr1966 Chemical Corp., Bryan, Tex.; CDL:090587-T) 

14-FebMontgomery, M.; Freed, V.H . (1961) The Absorption and Metabolism of Endothal when 1961 

Used as a Post-emergence Treatment for Beets -- Progress Report. (Unpublished study 08-Jul- 40977 received Apr 10, 1966 under 6G0503; prepared by Oregon State Univ., Agricultural 1965 

Chemistry Dept., submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-U) 10-Apr1966 

15-Dec1964 

21-Jan1965 

08-Jul1965 Montgomery, M.L.; Freed, V.H. (1964) Endothal. (Unpublished study received Apr 10, 

40981 1966 under 6G0503; prepared by Oregon State Univ., Dept. of Agricultural Chemistry, 15-Mar1966 submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-Y) 

Oregon State University (19) Preliminary Study on Microbial Effect on Endothal. 

40982 (Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt 

Chemical Corp., Bryan, Tex.; CDL:090587-Z) 

10-Apr1966 

15-Feb1967 

15-Apr1970 

10-Apr1966 

15-Feb1967 

01-Dec1970 

40985 

Bowles, E.J.; Carlson, R.E. (1964) Endothall Analysis. (Unpublished study received Apr 

10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; 

CDL:090587-AC) 

10-Apr1966 

Anon. (1967) 1967 Pennsylvania Guide, Chemical Weed Control for Vegetable Crops: 

41271 Selection, Application, Safety. University Park, Pa.: Pennsylvania State Univ., Extension 

Service. (Incomplete; also in unpublished submission received Oct 2, 1967 under 

02-Oct1967 

8F0643; submitted by Stauffer Chemical Co., Westport, Conn.; CDL:091116-AI) 

42579 Pennwalt Corporation (1973) Hydrothol 191 Rice Herbicide Summary-- Research Fie ld 

Tests. (Unpublished study received Jul 10, 1975 under 4581-18; CDL:243210-A) 

10-Jul1975 

44465 

Burkhalter, A.P. (1972) Guidelines for Aquatic Weed Control. Rev. By Florida, Dept. of 

Natural Resources, Bureau of Aquatic Plant Research and Control. Tallahasee, Fla.: 

Florida, DNR. (Published study; CDL:022791-A) 

24-May1974 

Swabey, Y.H.; Schenk, C.F. (1963) Report on Algicides and Aquatic Herbicides. 12-Jan46269 (Ontario, Water Resources Commission, Laboratory Division, Biology Branch, 1965 

unpublished study; CDL:107773-B) 14-Apr81
1966 

Fink, R. (1975) Final Report: Eight-Day Dietary LC50-Bobwhite Quail: Project No. 110­

52229 105. (Unpublished study received Oct 21, 1975 under 4581-EX-18; prepared by Truslow 

Farms, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 

21-Oct1975 

096340-A) 

Silvo, O.E.J. (1967) Alustavia Tutkimuksia Eraiden Herbisidien Myrkyllisyydesta 

55714 Nuorille Karpin Poikasille (Cyprinus carpio L.). N.P. (Suomen Kalatalous 32 Finlands 

Fiskerier; incomplete; also in unpublished submission received Jul 11, 1961 under 

11-Jul1961 

1E1046; submitted by U.S. Dept. of the Army, Washington, D.C.; CDL:093359 -X) 

57411 

Keckemet, O. (1974) Letter sent to Charlotte M. Young dated Feb 25, 1974 Efficacy 

studies on rice. (Unpublished study received May 1, 1974 under 4F1499; submitted by 

Uniroyal Chemical, Bethany, Conn.; CDL:094551-D) 

01-May1974 

58568 

Pennwalt Corporation (19) Endothall Technical. Tacoma, Wash.: Pennwalt. (Product data 

bulletin no. 13c; also in unpublished submission received Feb 1, 1975 under 3F1416; 

CDL:093785-D) 

01-Feb1975 

58575 

Pennwalt Corporation (1973) Analytical Method for Residues of Endothall in Various 

Crops and Other Materials. Method dated May 1973. (Unpublished study received Feb 1, 

1975 under 3F1416; CDL:093785-N) 

01-Feb1975 

58722 

Latven, A.R. (1977) Toxicology Report for ...: Endothall acid # 3441. (Unpublished study 

received Oct 26, 1978 under 4581-282; prepared by Pharmacology Research, Inc., 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:235435-D) 

26-Oct1978 

Brieger, H. (19) Results of Sub-acute Feeding Tests with Endothal. (Unpublished study 

61096 received on unknown date under unknown admin. no.; prepared by Jefferson Medical 

College, Div. of Industrial Medicine, submitted by ; CDL:109899-A) 

Anon. (1966) Summary of Toxicity Studies with Endothal Formulations on Animals. 

61097 (Unpublished study received on unknown date under unknown admin. no.; submitted by ; 

CDL:109890-A) 

61605 Anon. (1967) Acute Oral LD50 Data for Aquatic Herbicides. (Unpublished study 

received Nov 18, 1968 under unknown admin. no.; ; CDL:109792-A) 

18-Nov1968 

Simsiman, G.V.; Daniel, T.C.; Chesters, G. (1976) Diquat and endothall: Their fates in 

65605 the environment. Residue Reviews 62:131 - 174. (Also in unpublished submission 

received Aug 22, 1977 under 239-1663; submitted by Chevron Chemical Co., Richmond, 

22-Aug1977 

Calif.; CDL:231430-E) 

Schreck, C.B. (1974) Aquatic Plant Control Using Herbicides in a Large Potable Water 

67174 Supply Reservoir: Contract No. DACW65-74- C-0013. (Virginia Polytechnic Institute 

and State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, 

22-Aug1977 

Corps of Engineers; unpublished study; CDL:231433-D) 

67723 Pennsalt Chemical Corporation (1967) Chemical Data Regarding Des-i-cate. 

(Compilation; unpublished study received May 8, 1967 under 7G0608; CDL:092900-A) 

08-May1967 

67762 Pennwalt Corporation (1970) Chemical Data Regarding Endothall. (Unpublished study 

received Feb 1, 1975 under 4581-EX-21; CDL: 094575-A) 

01-Feb1975 

67763 

Keckemet, O. (1975) Reasonable Grounds in Support of the Petition for Residue 

Tolerance: Endothall. (Unpublished study received Feb 1, 1975 under 4581-EX-21; 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:094575-F) 

01-Feb1975 

69050 Pennwalt Corporation (1979) Human Safety: Summary of Toxicity Data. Summary of 23-Jan82
studies 099882-C and 099882-E through 099882- I. (Unpublished study received Jan 23, 1981 

1981 under 1F1105; CDL: 099882-B) 

Knickerbocker, M.; Becci, P.J. (1980) Teratologic Evaluation of Endothall in Rats: 

69051 

Laboratory No. 5129. (Unpublished study, including letters dated Dec 31, 1980 from 

C.H. Williams to Obren Keckemet and Jan 7, 1981 from R.A. Parent to Bernalyn 

McGaughey, received Jan 23, 1981 under 1F1105; prepared by Food and Drug Research 

23-Jan1981 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099882-C) 

Curren, R.D.; Schechtman, L.M.; Parmar, A.S.; et al. (1980) Activity of T1604 in the 

69054 

Salmonella/Microsomal Assay for Bacterial Mutagenicity: Study No. T1064.102. Final 

report. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by 

Microbiological Associates, submitted by Pennwalt Corp., Philadelphia, Pa.; 

23-Jan1981 

CDL:099882-G) 

Schechtman, L.M.; Beard, S.F.; Sinsky, P.M. (1980) Activity of T1604 in the in vitro 

69055 

Mammalian Cell Point Mutation Assay in the Absence of Exogenous Metabolic 

Activation: Study No. T1604.106. Final report. (Unpublished study received Jan 23, 1981 

under 1F1105; prepared by Microbiological Associates, submitted by Pennwalt Corp., 

23-Jan1981 

Philadelphia, Pa.; CDL:099882-H) 

Schechtman, L.M.; Beard, S.F.; Sinsky, P.M. (1980) Activity of T1604 in the in vitro 

69056 

Mammalian Cell Point Mutation Assay in the Presence of Exogenous Metabolic 

Activation: Study No. T1604.107. Final report. (Unpublished study received Jan 23, 1981 

under 1F1105; prepared by Microbiological Associates, submitted by Pennwalt Corp., 

23-Jan1981 

Philadelphia, Pa.; CDL:099882-I) 

Rodwell, D.E.; Spencer, A.G.; Allen, S.; et al. (1980) Range- finding Study in Non- 23-Jan69057 pregnant Female Mice: IRDC No. 470-004. (Unpublished study received Jan 23, 1981 

under 1F1105; prepared by International Research and Development Corp., submitted by 

1981 

29-JanPennwalt Corp., Philadelphia, Pa.; CDL:099882-J) 1981 

Bond, C.E.; Lewis, R.H.; Fryer, J.L. (1960) Toxicity of various herbicidal materials to 18-Mar69192 fishes. Pages 96-101, In Transactions of the 1959 Seminar of Biological Problems in 

Water Pollution. By Robert A. Taft Engineering Center. Cincinnati, Ohio: U.S. Public 

1976 

26-AprHealth Service. (Technical report W60-3; published study; CDL:230691-H) 1977 

71130 

Pennwalt Corporation (1979) Fish and Wildlife Safety Summary. Summary of studies 

244131-B through 222131-R. (Unpublished study received Jan 23, 1981 under 4581-174; 

CDL:244131-A) 

23-Jan1981 

Bodden, R.M. (1979) Avian Single-dose Oral LD50: Study No. W-910. (Unpublished 

71131 study, including letter dated Jul 8, 1980 from R.M. Bodden to Obren Keckemet, received 

Jan 23, 1981 under 4581- 174; prepared by Ralston Purina Co., submitted by Pennwalt 

23-Jan1981 

Corp., Philadelphia, Pa.; CDL:244131-B) 

Vilkas, A.G.; Hughes, J.S. (1979) The Acute Toxicity of Endothall to the Water Flea 

71137 Daphnia magna Straus: UCES Project No. 11506- 41-09. (Unpublished study received 

Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted by Pennwalt 

23-Jan1981 

Corp., Philadelphia, Pa.; CDL:244131-I) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 

71142 Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 

11506-41-11. (Un- published study received Jan 23, 1981 under 4581-174; prepared by 

23-Jan1981 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-O) 

71143 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 

Technical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus 

(Linnaeus): UCES Project No. 11506-41-12. (Unpublished study received Jan 23, 1981 

23-Jan1981 

83
under 4581-174; prepared by Union Carbide Corp., submitted by Pennwalt Corp., 

Philadelphia, Pa.; CDL:244131-P) 

Bailey, H.C. (1980) Letter sent to Bernalyn D. McGaughey dated Sep 19, 1980 

71145 

(Summary of results of 48-hour mussel embryo bio- assay performed on Endothall): SRI 

Project LSC-1514-6. (Unpublished study, including letter dated Jun 20, 1980 from H.C. 

Bailey to Bernalyn D. McGaughey, received Jan 23, 1981 under 4581-174; prepared by 

23-Jan1981 

SRI International, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-R) 

71446 Pennwalt Corporation (1981) Human Safety: Introduction. (Unpublished study received 

Mar 25, 1981 under 4581-223; CDL:099955-D) 

25-Mar1981 

Bodden, M.R. (1979) Avian Single-dose Oral LD50: Study No. W-910. Final report. 

72455 (Unpublished study, including letter dated Jul 8, 1980 from R.M. Bodden to Obren 

Keckemet, received Jan 23, 1981 under 1F1105; prepared by Ralston Purina Co., 

23-Jan1981 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-B) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 

72464 Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 

11506-41-11. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by 

23-Jan1981 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-O) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 

72465 

Technical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus 

(Linnaeus): UCES Project No. 11056-41-12. (Unpublished study received Jan 23, 1981 

under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt Corp., 

23-Jan1981 

Philadelphia, Pa.; CDL:099883-P) 

72467 

U.S. Department of Interior, Bureau of Reclamation (1964) Results of Algaecidal 

Evaluation Tests of Selected Compounds: Report No. WC-21. Annual progress report. of 

1964, laboratory studies. (Unpublished study; CDL:099883-U) 

23-Jan1981 

73305 

Keckemet, O. (1973) Reasonable Grounds in Support of the Petition: Endothall. 

(Unpublished study, including published data, received Feb 1, 1975 under 3F1416; 

submitted by Pennwalt Corp., Tacoma, Wash.; CDL:093785-H) 

01-Feb1975 

73337 

Pennwalt Corporation (1977) Human Safety: Summary of Toxicity Data. Summary of 

studies 235435-B through 235435-E. (Unpublished study received Oct 26, 1978 under 

4581-282; CDL:235435-A) 

26-Oct1978 

Rodwell, D.E.; Goldenthal, E.I.; Blair, M.; et al. (1980) Teratology Study in Mice: Study 

73371 No. 470-006. (Unpublished study received Jan 23, 1981 under 4581-174; prepared by 

International Research and Development Corp., submitted by Pennwalt Corp., 

23-Jan1981 

Philadelphia, Pa.; CDL:244123-J) 

Oborn, E.T.; Bartley, T.R. (1954) Tolerance of Crops to Herbicides in Irrigation Water: 

73854 

Laboratory Report No. SI-3. (U.S. Agricultural Research Service, Field Crops Research 

Branch and U.S. Dept. of the Interior, Bureau of Reclamation, Office of the Assistant 

Commissioner and Chief Engineer, Engineering Laboratories; unpublished study; 

03-Mar1971 

CDL:090913-I) 

74220 

Bodden, R.M. (1979) Avian Single-dose Oral LD50. (Unpublished study received Jan 23, 

1981 under 4581 -282; prepared by Ralston Purina Co., submitted by Pennwalt Corp., 

Philadelphia, Pa.; CDL:244122-B) 

23-Jan1981 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) 

74224 Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 

11506-41-11. (Unpublished study received Jan 23, 1981 under 4581-282; pre - pared by 

23-Jan1981 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-O) 

84
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Endothall (Acid Monohydrate) 

74225 

Technical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus 

(Linnaeus): UCES Project No. 11506-41-12. (Unpublished study received Jan 23, 1981 

under 4581-282; prepared by Union Carbide Corp., submitted by Pennwalt Corp., 

23-Jan1981 

Philadelphia, Pa.; CDL:244122-P) 

Bailey, H.C. (1980) Letter sent to Bernalyn D. McGaughey dated Sep 19, 1980 Results of 

74227 48-hour mussel embryo bioassay performed on Endothal: SRI Project LSC-1514-6. 

(Unpublished study received Jan 23, 1981 under 4581-282; prepared by SRI 

23-Jan1981 

International, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-R) 

74228 Pennwalt Corporation (19) Toxicity Testing Protocols: Mussel Embryo Test. 

(Unpublished study received Jan 23, 1981 under 4581-282; CDL:244122-S) 

23-Jan1981 

75236 

Brieger, H. (1950) Preliminary Toxicity Studies on Endothal. (Jefferson Medical College, 

Div. of Industrial Medicine for U.S. Food and Drug Administration; unpublished study; 

CDL: 109911-A) 

21-Mar1951 

Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology 

78180 reports on seven products. (Unpublished study received Jan 5, 1978 under 4581-174; 

prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 

05-Jan1978 

Pa.; CDL:232580-B) 

Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Endothall 

78181 Technical (N.B. 58-196-2). (Unpublished study received Jan 5, 1978 under 4581-174; 

prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 

05-Jan1978 

Pa.; CDL:232580-C) 

Stevens, K.R. (1976) Teratologic Evaluation of Endothall in Rats: Laboratory No. 5129. 

78611 (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Food and Drug 

Research Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 

05-Jan1978 

232580-BI) 

Sikka, H.C.; Saxena, J. (1973) Metabolism of endothall by aquatic microorganisms. 

79977 Journal of Agricultural and Food Chemistry 21 (3):402-406. (Also in unpublished 

submission received Feb 1, 1975 under 4581-EX-21; submitted by Pennwalt Corp., 

01-Feb1975 

Philadelphia, Pa.; CDL:094575-G) 

80437 

Pennsalt Chemicals Corporation (1954) Full Reports of Investigations Made with Respect 

to the Safety of the Product. (Unpublished study received Feb 4, 1966 under 6G0503; 

CDL:090585-B) 

04-Feb1966 

10-Jun1966 

Montgomery, M.L.; Freed, V.H. (1964) Preliminary Study on Microbial Effect on 

80439 Endothal. (Unpublished study received Feb 4, 1966 under 6G0503; prepared by Oregon 

State Univ., Dept. of Agricultural Chemistry, submitted by Pennsalt Chemicals Corp., 

04-Feb1966 

Tacoma, Wash.; CDL:090585-D) 

81397 

Pennwalt Corporation (1966) Toxicological Investigations, Mammals: Summary. 

Summary of studies 051133-B through 051133-M and 051133-R. (Unpublished study 

received Apr 14, 1966 under 4581- 70; CDL:051133-A) 

14-Apr1966 

15-DecKeller, J.G.; Platt, W.R.; Steingruby, P.B. (1964) Final Report on Three-week Repeated 1964 

81400 Dermal Application of Herbicide 282 to Albino Rabbits: S.A. No. 95431. (Unpublished 

study received Apr 14, 1966 under 4581-70; prepared by Scientific Associates, Inc., 

14-Apr1966 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 051133-D) 10-Jun1966 

85
81403 

U.S. Agricultural Research Service (1954) Toxicity of Endothal to Sheep. (Field Crops 

Research Branch, Irrigation Experiment Station, Weed Investigation Section; unpublished 

study; CDL: 051133-G) 

14-Apr1966 

10-Jun1966 

81404 

Brieger, H. (1953) Endothal: Long-term Oral Toxicity Test. (Unpublished study received 

Apr 14, 1966 under 4581-70; prepared by Jefferson Medical College, submitted by 

Pennwalt Corp., Philadelphia, Pa.; CDL:051133-H) 

14-Apr1966 

10-Jun1966 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate), 

83026 89.5% Acid Equivalent, to the Grass Shrimp Palaemonetes pugio: UCES Project No. 

11506-41-10. (Unpublished study received Jan 23, 1981 under 4581-174; prepared by 

23-Jan1981 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-L) 

83032 Pennwalt Corporation (1979) Fish and Wildlife Safety: Summary. (Unpublished study 

received Mar 25, 1981 under 4581-223; CDL: 244664-A) 

25-Mar1981 

25-Mar83033 Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 

244662-B. (Unpublished study received Mar 25, 1981 under 4581-223; CDL:244662-A) 

1981 

14-Sep1981 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate), 

83108 89.5% Acid Equivalent, to the Grass Shrimp Palaemonetes pugio: UCES Project No. 

11506-41-10. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by 

23-Jan1981 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-L) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate), 

84151 89.5% Acid Equivalent, to the Grass Shrimp Palaemonetes pugio: UCES Project No. 

11506-41-10. (Unpublished study received Jan 23, 1981 under 4581-282; prepared by 

23-Jan1981 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-L) 

84382 

Seaman, D.E.; Berkenkotter, P.; Chen, T.M.; et al. (1966) Persistence of Residues and 

Fates of Herbicides in Rice Fields and in Rice-field Effluents: Progress report WRC 

Project No. W 3 02 67. for the period Mar 1, 1965 to Jan 31, 1966. (Unpublished study 

received Oct 8, 1981 under 476-2107; prepared by Univ. of California--Davis, Dept. of 

Botany, submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:246011-M) 

08-Oct1981 

14-Oct1983 

Carlson, R.; Whitaker, R.; Landskov, A. (1978) Endothall. Pages 327-340, In Analytical 

84602 Methods for Pesticides and Plant Growth Regulators. New York, N.Y.: Academic Press, 

Inc. (also in unpublished submission received Sep 14, 1981 under 4581-349; submitted 

14-Sep1981 

by Pennwalt Corp., Philadelphia, Pa.; CDL:246016-B) 

84603 Pennwalt Corporation (1951) Human Safety: Summary of Toxicity Data. (Unpublished 

study received Sep 14, 1981 under 4581-349; CDL:246012-A) 

14-Sep1981 

84604 

Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012-J 

through 246012-P. (Unpublished study received Sep 14, 1981 under 4581-349; 

CDL:246012-B) 

14-Sep1981 

84606 Pennwalt Corporation (1979) Teratology: Endothall. (Unpublished study received Sep 14, 

1981 under 4581 -349; CDL:246012-D) 

14-Sep1981 

84607 Pennwalt Corporation Metabolism Studies: Endothall. (Unpublished study received Sep 

14, 1981 under 4581-349; CDL: 246012-E) 

14-Sep1981 

84611 Pennwalt Corporation (1972) Mutagenicity Studies: Endothall. (Unpublished study 

received Sep 14, 1981 under 4581 -349; CDL: 246012-I) 

14-Sep1981 

86
84613 

Ralston Purina Company (1981) Endothal Granular Turf Herbicide: RT Lab No. 867431. 

(Unpublished study received Sep 14, 1981 under 4581-349; submitted by Pennwalt Corp., 

Philadelphia, Pa.; CDL: 246012-O) 

14-Sep1981 

Blair, M.; Nemec, M.D.; Bajo, C.; et al. (1981) Teratology Study in Mice: 470-006. 02-Jul85940 (Unpublished study received Sep 3, 1981 under 1F1105; prepared by International 

Research and Development Corp., submitted by Pennwalt Corp., Tacoma, Wash.; CDL: 

1981 

03-Sep070277-A; 070276) 1981 

86622 

Scribner, J.D. (1981) Evaluation of Studies on Genetic Toxicity of Endothall. 

(Unpublished study received Jul 29, 1981 under 4581-204; submitted by Pennwalt Corp., 

Philadelphia, Pa.; CDL:245680-D) 

29-Jul1981 

86623 Pennwalt Corporation (1981) Endothall Teratology Study in Mice. (Unpublished study 

received Nov 12, 1981 under 1F1105; CDL: 070448-A) 

12-Nov1981 

88988 

Bowmer, W.J. (1981) Letter sent to Richard F. Mountfort dated Dec 14, 1981 

Information on residue and deposition of drift data. (Texas, Dept. of Agriculture, 

Agricultural & Environmental Sciences Div.; unpublished study; CDL:246530-A) 

28-Dec1981 

88989 

Landskov, A. O. (1981) Letter sent to Letha Coenen dated Nov 25, 1981: Residues of 

endothall on cotton seed. (Unpublished study received Dec 28, 1981 under TX 81/47; 

prepared by Pennwalt Corp., submitted by state of Texas, Austin, Tex.; CDL:246531-B) 

28-Dec1981 

90431 Anon. (1954) Toxicity of Endothal to Sheep. (Unpublished study received on unknown 

date under unknown admin. no.; CDL:109906 -A) 

Fang, S.C.; Tinsley, I. (1967) Metabolism of C14I-labeled Disodium 3,6-

96294 

Endoxohexahydrophthalate (Endothall) in Rats. Final report. (Unpublished study, 

including letter dated Oct 14, 1966 from R.E. Carlson to D.M. Baker, Jr., received Feb 

17, 1967 under 7F0570; prepared by Oregon State Univ., Dept. of Agricultural 

17-Feb1967 

Chemistry, submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719-E) 

96299 

Menzie, C.M. (1964) Letter sent to H.L. Lindaberry dated Oct 15, 1964 Toxicity to 

mallards. (U.S. Fish and Wildlife Service, Patuxent Wildlife Research Center, Section of 

Chemical and Physiological Studies; unpublished study; CDL:090719-K) 

23-Mar1967 

Peoples, S.A. (1965) The Excretion of C14 Tagged Endothall in the Rat. (Unpublished 

96300 study received Feb 17, 1967 under 7F0570; prepared by Univ. of California --Davis, Dept. 

of Physical Sciences, submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL: 

17-Feb1967 

090719-L) 

Maestri, M. (1967) Structural and Functional Effects of Endothall on Plants. 17-Feb96302 (Unpublished study, including letter dated Nov 3, 1966 from H.B. Currier to Edward J. 

Bowles, received Feb 17, 1967 under 7F0570; prepared by Univ. of California--Davis, 

1967 

15-AprDept. of Botany, submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719-R) 1970 

97377 

Tischler, N.; Bates, J.C.; Quimba, G.P. (1949) A New Group of Defoliant-herbicidal 

Chemicals. (Unpublished study received Dec 5, 1949 under unknown admin. no.; 

submitted by Sharples Chemical, Inc., Philadelphia, Pa.; CDL:109908 -A) 

05-Dec1949 

97424 

Carlson, R.E. (1977) Letter sent to Obren Keckemet dated Oct 25, 1977: Effect of yeast 

culture on endothall. (Unpublished study received Jan 5, 1978 under 1F1105; submitted 

by Pennwalt Corp., Philadelphia, Pa.; CDL:096704-E) 

05-Jan1978 

Applied Biochemists, Incorporated Nomenclature, Chemical and Physical Properties of 

99327 Endothal Technical (Acid) and Cutrine, a Copper Triethanolamine Complex. 

(Compilation; un- publis hed study received Dec 21, 1972 under unknown admin. no.; 

21-Dec1972 

CDL:127670-A) 

87
Schreck, C.; Corning, R.; Berry, C.; et al. (1974) Aquatic Plant Control Using Herbicides 

100609 

in a Large Potable Water Supply Reservoir. Annual report, Jul 1, 1973--Jun 30, 1974: 

Contract No. DACW65-74-C-0013. (Virginia Polytechnic Institute and State Univ., Dept. 

of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Corps of Engineers; 

02-Dec1974 

unpublished study; CDL:247354-B) 

Silvo, O. (1967) Alustavia Tutkimuksia Eraiden Herbisidien Myrkyllisyydesta Nuorille 

102855 Karpin Poikasille (Cyprinus catpio L.). Helsinki, Fin.: species name. (Suomen Kalatalous 

32; also in unpublished submission received Feb 3, 1976 under 960-163; sub- mitted by 

03-Feb1976 

Balcom Chemicals, Inc., Greeley, CO; CDL:228944-V) 

Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, 

108102 Including a Description of the Analytical Methods Used: (Endothall). (Unpublished study 

received Feb 1, 1975 under 4G1449; submitted by Pennwalt Corp., Tacoma, WA; CDL: 

01-Feb1975 

093861-A) 

Moffett, J.; Morton, H.; MacDonald, R. (1972) Toxicity of some herbicidal sprays to 26-Sep111488 honey bees. Journal of Economic Entomology 65(1):32-36. (Also In unpublished 

submission received Sep 26, 1974 under 464-323; submitted by Dow Chemical U.S.A., 

1974 

15-DecMidland, MI; CDL:120345-H) 1983 

113925 Agchem (1959) Environmental Studies on Endothal. (Compilation; unpublished study 

received Dec 3, 1959 under 4581-139; CDL: 007440 -A) 

03-Dec1959 

113927 

Agchem (1966) Description of Analytical Methods and Results of Analyses for 

Dimethylcocoamine Endothall (Accelerate) in Cotton- seed. (Compilation; unpublished 

study received Feb 14, 1966 under 4581-284; CDL:007456-A) 

14-Feb1966 

Kennedy, G. (1970) Report to Pennwalt Corporation: Distribution of 14C-Endothall in 

113928 the Goat: IBT No. E8392. (Unpublished study received Dec 15, 1970 under 0F0972; 

prepared by Industrial Bio-Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, 

15-Dec1970 

WA; CDL:091670-A) 

Kennedy, G. (1970) Report to Pennwalt Corporation: Characterization of 14C in Milk 

113929 and Urine of Goats Following Oral Administration of 14C-Endothall: IBT No. E8392. 

(Unpublished study received Dec 15, 1970 under 0F0972; prepared by Industrial Bio-Test 

15-Dec1970 

Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:091670-B) 

Kennedy, G.; Jenkins, D. (1970) Report to Pennwalt Corporation: Tissue Residue Study 

113930 

with 14C Labeled Endothall in Pre-conditioned and Naive White Leghorn Chickens: IBT 

No. J8352. (Unpublished study received Dec 15, 1970 under 0F0972; prepared by 

Industrial Bio-Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; 

15-Dec1970 

CDL:091670-C) 

113934 

Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the 

Product: Endothall. (Unpublished study received Dec 1, 1970 under 1F1105; submitted 

by Pennwalt Corp., Tacoma, WA; CDL:094510-A) 

01-Dec1970 

113935 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 

(Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094508-A) 

01-Dec1970 

113936 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 

(Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094507-A) 

01-Dec1970 

113937 Pennwalt Corp. (1970) Study: Hydrothol Efficacy. (Compilation; unpublished study 

received Dec 1, 1970 under 1F1105; CDL: 094507-B) 

01-Dec1970 

113938 

Pennwalt Corp. (1972) Toxicity Study: Endothall on Rats & Fish. Summary of studies 

094506-C and 094506-D. (Unpublished study received May 31, 1972 under 1F1105; 

CDL:094506-B) 

31-May1972 

88
113952 

Walsh, G. (1971) Effects of Herbicides on Photosynthesis and Growth of Marine 

Unicellular Algae. (Environmental Protection Agency, Gulf Breeze Laboratory; 

unpublished study; CDL:094506-F) 

13-May1972 

28-Apr113953 

Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining, 

Including a Description of the Analytical Method Used: Endothall. (Compilation; 

unpublished study received May 13, 1972 under 1F1105; CDL:094506-H) 

1972 

04-May1972 

13-May1972 

Pennwalt Corp. (1971) A Report of Two Studies on Residues in Potatoes and Soil after 

113954 Treatment with Endothall and 14C Endothall Formulated as DES -I-CATE. (Compilation; 

unpublished study received on unknown date under 1F1057; CDL:093370-A) 

113957 

Pennwalt Corp. (1971) Name, Chemical Identity and Composition of Pesticide Chemical: 

Endothall. (Compilation; unpublished study received Jan 20, 1971 under 1F1057; 

CDL:093370-E) 

20-Jan1971 

113959 

Watson, J. (1971) Full Reports of Investigations Made with Respect to the Safety of the 

Product: Endothall. (Unpublished study received Aug 11, 1971 under 1F1057; submitted 

by Pennwalt Corp., Tacoma, WA; CDL:091892-A) 

11-Aug1971 

113961 

Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of 

the Product: Endothall. Summary of studies 091673-B through 091673 -E. (Compilation; 

unpublished study received Apr 7, 1970 under 0F0972; CDL:091673-A) 

07-Apr1970 

07-Apr113964 Pennwalt Corp. (1968) Study: 14C Endothall Residue in Specified Products. 

(Compilation; unpublished study received Apr 7, 1970 under 0F0972; CDL:091673-D) 

1970 

15-Apr1970 

113970 Pennwalt Corp. (1963) Uptake, Distribution and Metabolism of Endothall in Blue Gills. 

(Unpublished study received May 1, 1974 under 4G1510; CDL:094010-D) 

01-May1974 

113971 

Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of 

the Product: Endothall. (Compilation; unpublished study received on unknown date under 

1F1105; CDL:094509-A) 

03-May1971 

08-Jul113974 

Oregon State Univ. (1962) Progress Report on the Endothal Project. Progress report no. 

2. (Unpublished study received Jul 8, 1965 under 4581-232; submitted by Agchem Div., 

Pennwalt Corp., Philadelphia, PA; CDL:121844-B) 

1965 

01-Dec1970 

14-Nov1984 

Montgomery, M. (1962) Letter sent to O. Keckemet dated Oct 16, 1962 Endothal in soil. 

113975 Progress report. no. 3. (Unpublished study received Jul 8, 1965 under 4581-232; prepared 

by Oregon State Univ., Dept. of Agricultural Chemistry, Agricultural Experiment Station, 

08-Jul1965 

submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:121844-C) 

08-JulComes, R.; Bohmont, D.; A lley, H. (1961) Movement and persistence of endothal as 1965 

113977 influenced by soil texture, temperature, and moisture levels. Journal of the A.S.S.B.T. 

XI(4):287-293. (Also In unpublished submission received Jul 8, 1965 under 4581- 232; 

01-Dec1970 

submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:121844-L) 14-Nov1984 

113978 Agchem Movement and Persistence of Endothal under Controlled Conditions. 08-Jul89
(Unpublished study received Jul 8, 1965 under 4581- 232; CDL:121844-M) 1965 

113979 

Temby, F. (1963) Biological Breakdown of Endothal Compounds. (Unpublished study 

received Jul 8, 1965 under 4581-232; submitted by Agchem Div., Pennwalt Corp., 

Philadelphia, PA; CDL: 121844-N) 

08-Jul1965 

113980 

Temby, F. (1963) Soil Movement Studies wit h Endothal Compounds. (Unpublished study 

received Jul 8, 1965 under 4581-232; submitted by Agchem Div., Pennwalt Corp., 

Philadelphia, PA; CDL: 121844-O) 

08-Jul1965 

113981 

Temby, F. (1963) Soil Adsorption Studies--Endothal Compounds. (Un- published study 

received Jul 8, 1965 under 4581-232; submitted by Agchem Div., Pennwalt Corp., 

Philadelphia, PA; CDL:121844-P) 

08-Jul1965 

113982 

Hiltibran, R. Duration of toxicity of endothal in water. Source unknown. (Also In 

unpublished submission received Jul 8, 1965 under 4581-232; submitted by Agchem 

Div., Pennwalt Corp., Philadelphia, PA; CDL:121844-Q) 

08-Jul1965 

15-May1966 

Freed, V.; Montgomery, M.; Fang, S. (1958) The Absorption and Translocation of C14 08-Sep113986 Labeled Endothal in Red Beets and Spinach. (Un published study received Sep 8, 1958 

under unknown admin. no.; prepared by Pennsylvania Salt Mfg. Co. of Washington, 

1958 

08-Julsubmitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL: 124421-A) 1965 

113987 

Agchem (1970) The Results of Tests on the Amount of Residue Remaining Including a 

Description of the Analytical Method Used: Endothall. (Compilation; unpublished study 

received Jun 27, 1971 under unknown admin. no.; CDL:124882-A) 

27-Jun1971 

113988 Medical Products (1970) Residue Section: (Endothall). (Unpublished study received on 

unknown date under 7182-EX-8G; CDL:125806-A) 

114487 

Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and 

Complete Composition of the Product: Endothall. (Compilation; unpublished study 

received Jul 9, 1975 under 1F1105; CDL:094700-A) 

09-Jul1975 

114488 

Pennwalt Corp. (1975) Full Reports and Data of Investigations Made on the Safety of the 

Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study 

received Jul 9, 1975 under 1F1105; CDL:094702-A) 

09-Jul1975 

114492 

Pennwalt Corp. (1972) Responses of Plankton and Macrofauna Communities To Test 

Application of Chemical Herbicides. (Unpublished study received Jul 9, 1975 under 

1F1105; CDL:094702-H) 

09-Jul1975 

Schreck, C. (1974) Aquatic Plant Control Using Herbicides in a Large Potable Water 

114495 

Supply Reservoir: Contract No. DACW65-74-C- 0013. Annual report. Jul 1, 1973-Jun 

30, 1974. (Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and Wildlife 

Sciences for U.S. Dept. of the Army, Corps of Engineers; unpublished study; 

09-Jul1975 

CDL:094702-L) 

114500 Pennwalt Corp. (1975) Toxicity: Endothall. (Compilation; unpublished study received Jul 

9, 1975 under 1F1105; CDL:094706-B) 

09-Jul1975 

114502 Pennwalt Corp. (1972) Biomagnification: Endothall. (Compilation; unpublished study 

received Jul 9, 1975 under 1F1105; CDL: 094706-D) 

09-Jul1975 

114503 Pennwalt Corp. (1975) Metabolism: Endothall. (Unpublished study received Jul 9, 1975 

under 1F1105; CDL:094706-E) 

09-Jul1975 

114504 Pennwalt Corp. (1975) Duration of Biological Activity: Endothall. (Unpublished study 

received Jul 9, 1975 under 1F1105; CDL: 094706-F) 

09-Jul1975 

90
114505 Agchem (1954) Toxicological Investigations--Mammals: Endothall. (Unpublished study 

received Mar 15, 1966 under 4581-139; CDL: 007441-A) 

15-Mar1966 

114518 Agchem Residue Analytical Methods: Endothal. (Unpublished study received Mar 15, 

1966 under 4581 -139; CDL:007441-S) 

15-Mar1966 

114519 

Oregon State Univ. Preliminary Study on Microbial Effect on Endothal. (Unpublished 

study received Mar 15, 1966 under 4581- 139; submitted by Agchem Div., Pennwalt 

Corp., Philadelphia, PA; CDL:0074419-V) 

08-Jul1965 

15-Mar1966 

Lewandowski, T. (1953) Letter sent to P. Munter dated Aug 20, 1953: Microbiological 

114520 examination of Endothal. (Unpublished study received Mar 15, 1966 under 4581-139; 

prepared by Pennsylvania Salt Mfg. Co., submitted by Agchem Div., Pennwalt Corp., 

15-Mar1966 

Philadelphia, PA; CDL:007441-W) 

114521 

Freed, V.; Montgomery, M. (1963) Progress Report on the Study of the Degradation 

Products of Endothal in Soil. (Unpublished study received Mar 15, 1966 under 4581-139; 

prepared by Oregon State Univ., Agricultural Experiment Station, Dept., of Agricultural 

Chemistry, submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:007441-

X) 

08-Jul1965 

15-Mar1966 

114523 Agchem (1961) Chemical Study: Endothal. (Compilation; unpublished study received 

Mar 15, 1966 under 4581-139; CDL: 007441-AB) 

15-Mar1966 

114531 

Agchem (1972) Toxicity of Endothall in Animals. Summary of studies 095336-H, 

094506-C and 094506-D. (Unpublished study received May 4, 1972 under 4581-284; 

CDL:095336-C) 

04-May1972 

114534 

Food and Drug Research Laboratories, Inc. (1976) Teratologic Evaluation--Agricultural 

Chemical FDRL/Wistar Rats: Protocol No. 76081. (Unpublished study received Jun 4, 

1976 under 3F1416; submitted by Pennwalt Corp., Tacoma, WA; CDL:095419-A) 

04-Jun1976 

114537 Pennwalt Corp. (1973) Analyses for Residues of Endothall in Various Crops. 

(Compilation; unpublished study received Jun 27, 1973 under 3F1416; CDL:095419-D) 

27-Jun1973 

114538 

Pennwalt Corp. (1969) Determination of Endothall Residues in Cottonseed and 

Cottonseed Products. (Compilation; unpublished study received Apr 15, 1970 under 

0F0972; CDL:095421-A) 

15-Apr1970 

114540 

Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the 

Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15, 

1970 under 0F0972; submitted by Pennwalt Corp., Tacoma, WA; CDL:095421-F) 

15-Apr1970 

15-Nov114547 3M Co. (1965) Chemical and Physical Properties: System E. (Unpublished study received 

Dec 19, 1975 under 6H5112; CDL: 225291-A) 

1973 

19-Dec1975 

18-NovKohn, F.; Kay, D. (1968) Report to Minnesota Mining and Manufacturing Co: Acute 1968 

114548 Toxicity Studies on 3ME68H: Lifestream Laboratories Project Nos. 984 through 988. 

(Unpublished study received Dec 19, 1975 under 6H5112; prepared by Lifestream 

15-Nov1973 

Laboratories, Inc., submitted by 3M Co., St. Paul, MN; CDL:225291-C) 19-Dec1975 

114549 

Economon, P. (1967) Letter sent to W. Paterson dated Nov 3, 1967 Results of bioassay 

on aquatic herbicide compounds. (Minnesota, Dept. of Conservation, Div. of Game and 

Fish, Technical Services; unpublished study; CDL:225291-D) 

15-Nov1973 

19-Dec1975 

91
Whitley, J. (1968) Letter sent to W. Paterson dated Nov 18, 1968 Four-day fish toxicity 15-Nov114551 tests on bluegill sunfish, black bull- head and mosquitofish. (Missouri, Dept. of 

Conservation, Fisheries Research Laboratory, Water Quality Investigations; unpublished 

1973 

19-Decstudy; CDL:225291 -F) 1975 

114552 

Bionomics, Inc. (1971) The Acute Toxicity of System E (T-350) to Bluegill ..., Rainbow 

Trout ..., and Largemouth Bass (Micropterus salmoides). (Unpublished study received 

Dec 19, 1975 under 6H5112; submitted by 3M Co., St. Paul, MN; CDL:225291-G) 

15-Nov1973 

19-Dec1975 

15-Nov114553 3M Co. (1971) Study IX: Field Trial Observations: System E. (Unpublis hed study 

received Dec 19, 1975 under 6H5112; CDL: 225291-I) 

1973 

19-Dec1975 

114554 3M Co. (1974) Residue Studies and Methods: System E. (Unpublished study received 

Dec 19, 1975 under 6H5112; CDL:225291-J) 

19-Dec1975 

114555 Agchem (1977) Environmental Chemistry: Introduction: (Hydout). (Compilation; 

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114556 

Carlson, R.; Sandeno, J. (1970) Effect of Endothall on the Growth of Several Fungi. 

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26-Oct1978 

114929 BASF Wyandotte Chemical Corp. (1973) Chemical Study: Pyramin -283. (Compilation; 

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115377 

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115982 

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Watson, J. (1972) Full Reports of Investigations Made with Respect to the Safety of the 

116026 Pesticide Chemical: Endothall. Summary of studies 090872 -C through 090872-G. 

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Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the 

116029 Product: Endothall. (Unpublished study received on unknown date under 1F1105; 

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116270 No. 110-105. Final report. (Unpublished study received Jul 9, 1975 under 1F1105; 

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Fink, R. (1975) Eight-day Dietary LC50--Mallard Ducks: Technical Endothal: Project 

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Mastri, C. (1971) Report to 3M Company: Acute Dermal Irritation/ Sensitization 15-Nov116272 Immersion Study with Two Concentrations of T-370 in Albino Guinea Pigs: IBT No. 

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06-Mar1969 

116739 

Chevron Chemical Co. (1977) Residue Chemistry Data and Data Reference List To 

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22-Aug1977 

Scott, R.; Gangstad, E. (1971) Technical Report of Monitoring Guidelines for Use: 

116862 Registration of Herbicides in Quiescent Aquatic Sites: AD882977. (U.S. Dept. of the 

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117183 Liquid Herbicides. (Unpublished study received Nov 26, 1963 under unknown admin. 

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118549 Amchem Products, Inc. (1971) Fenac Residue Data--Total Water Treatment. 

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07-Jul1972 

118951 Pennwalt Corp. (1982) Human Safety: Summary of Endothall Toxicity Data. 

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Harris, S.; Holson, J.; Barnett, W.; et al. (1982) A Teratology and Postnatal Behavioral 

118952 Study of Endothall Technical in Albino Rats: PNW/SAI 1182006. (Unpublished study 

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124005 

Agchem (1975) Full Reports and Data of Investigation Made on the Effectiveness of the 

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01-Feb1975 

124622 

Agchem (1970) Some Additional Information Pertaining to Fate of Endothall in the 

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01-Dec1970 

124624 

Oregon State Univ. (1963) Progress Report on the Soil Behavior of Endothal. 

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1970 

14-Nov094511-F) 1984 

124626 

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01-Dec1970 

124627 

Horowitz, M. (1966) Breakdown of Endothal in soil. Weed Research 6(2):168-171. (Also 

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124628 

Oregon State Univ. Preliminary Study on Microbial Effect on Endothal. (Unpublished 

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15-Feb1967 

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Jensen, H. (1964) Studies on soil bacteria (Arthrobacter globi-formis) capable of 

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124630 

Debona, A.; Audus, L. (1970) Studies on the effects of herbicides on soil nitrification. 

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124659 

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124660 

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133190 Pennwalt Corp. (1970) Fate of Endothall in Crops and Animals. Unpublished 

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27-Apr1970 

House, W.; Goodson, L.; Gadberry, H.; et al. (1967) Assessment of Ecological Effects of 

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138450 Doctor's thesis, Michigan State Univ., Dept. of Crop and Soil Sciences. (Unpublished 

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07-Jun147122 Carlson, R. (1985) The Hydrolysis of Endothall in Water: Project No. WT-3-85. 

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1985 

05-Aug1985 

147123 Pennwalt Corp. (1985) Photodegradation of Endothall in Water. Unpublished study. 9 p. 05-Aug1985 

07-Jun147124 Pennwalt Corp. (1985) Photodegradation of Endothall on Soil. Un- published study. 10 p. 1985 

05-Aug1985 

149675 

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07-Jun1985 

151771 Pennwalt Corp. (1984) EPA Ground Water Data Call-in for Endothall of July 27, 1984: 

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14-Nov1984 

156635 

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162920 

Dykeman, R. (1986) Aerobic/Anaerobic Soil Metabolism of Endothall: Final Report: 

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162921 

Jacobson, S. (1986) Terrestrial Field Dissipation Studies for Endothall (Herbicide 273 

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165311 

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165312 Supervisor Product Toxicology - 3M Co. (1973) Residue Studies and Methods: 

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40109200 Pennwalt Corp. (1987) Submission of Product Chemistry and Toxicity Studies in Support 

of Application for Registration of Endothall 30P. Transmittal of 4 studies. 

06-Mar1987 

40109201 Harvey, J. (1986) Endothal 30P--Product Chemistry. Unpublished compilation prepared 

by Pennwalt Corp. 10 p. 

06-Mar1987 

40109202 Smith, S. (1986) Acute Oral LD50 Study in Rats with Pelletted Endothall: Project ID: 

480-2553. Unpublished study prepared by American Biogenics Corp. 32 p. 

06-Mar1987 

40109203 Smith, S. (1986) Acute Dermal LD50 Study in Rabbits with Pelletted Endothall: Project 

ID: 480-2578. Unpublished study prepared by American Biogenics Corp. 29 p . 

06-Mar1987 

40109204 Smith, S. (1986) Primary Dermal Irritation Study in Rabbits with Pelletted Endothall: 06-Mar95
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41040300 Pennwalt Corp. (1989) Submission of Data To Support Registration of Endothall: 

Toxicology Data. Transmittal of 1 study. 

23-Mar1989 

41040301 

MacKenzie, K. (1989) Combined Chronic Toxicity and Carcinogenicity Study in Rats: 

Project ID: HLA 6120-110. Unpublished study pre- pared by Hazleton Laboratories 

America, Inc. 385 p. 

23-Mar1989 

41616400 

Atochem North America (1990) Submission of Product Chemistry Data and 

Environmental Fate Data to Support the List B Phase 2/3 Response of Endothal. 

Transmittal of 4 Studies. 

31-Aug1990 

41616404 

Vigon, B. (1989) Adsorption/Desorption of Carbon 14 ring (2,3) Endothall on Soils by 

the Batch Equilibrium Method: Lab Project Number: NO962/6200. Unpublished study 

prepared by Battelle. 68 p. 

31-Aug1990 

41622800 Atochem North America (1990) Submission of Product Chemistry Data to Support Phase 

2/3 Response for Endothall and Salts. Transmittal of 2 studies. 

07-Sep1990 

41622801 

Hoffman, M. (1988) Water Solubility Determination of Endothall: Lab Project Number: 

HLA/6001/183. Unpublished study prepared by Hazleton Laboratories America, Inc. 92 07-Sep1990 

p. 

41622802 

Hoffman, M. (1988) Determination of Vapor Pressure: Lab Project Number: 

HLA/6001/184. Unpublished study prepared by Hazleton Laboratories America, Inc. 120 07-Sep1990 

p. 

41700300 Atochem North America (1990) Submission of Toxicology Data To Support List B ­

Phase 2/3 Response for Endothall Technical. Transmittal of 3 studies. 

27-Nov1990 

41700301 

Mackay, J. (1989) Endothall Technical: Assessment of Clastogenic Action on Bone 

Marrow Erythrocytes in the Micronucleus Test: Lab Project Number: PSV/034: 

89/PSV034/0044. Unpublished study pre- pared by Life Science Research. 34 p. 

27-Nov1990 

Bootman, J.; Hodson-Walker; G.; Dance, C. (1989) In vitro Assessment of the 

41700302 Clastogenic Activity of Endothall Technical in Cultured Human Lymphocytes: Lab 

Project Number: PSV/027. Un- published study prepared by Life Science Research Ltd. 

27-Nov1990 

31 p. 

41700303 

Bootman, J.; May, K. (1988) Endothall Technical: Assessment of its Ability to Cause 

Lethal DNA Damage in Strains of Escherichia coli: Lab Project Number: PSV/028. 

Unpublished study prepared Life Science Research Ltd. 26 p. 

27-Nov1990 

42221500 Atochem North America (1992) Submission of Data in Response to Data Call-in for 

Endothall: Toxicology Study. Transmittal of 1 study. 

28-Feb1992 

42221501 

Cracknell, S. (1988) Endothall Technical: Acute Inhalation Toxicity Study in the Rat: 

Lab Project Number: 90/PSV024/0970: 88/0598. Unpublished study prepared by Life 

Science Research Ltd. 5 p. 

28-Feb1992 

42289200 

Atochem North America (1992) Submission of Data in Support of Endothall Acid 

(Technical) as Required in the List B Reregistration DCI: Toxicology and Environmental 

Fate Studies. Transmittal of 7 studies. 

20-Apr1992 

42289201 

Mallory, V. (1991) Acute Exposure Oral Toxicity in Rats with Endothall Technical: Lab 

Project Number: PH 402-ANA-002-91. Unpublished study prepared by Pharmakon 

Research International, Inc. 53 p. 

20-Apr1992 

42289202 Mallory, V. (1991) Acute Exposure Dermal Toxicity with Endothall Technical: Rabbit: 

Lab Project Number: PH 422-ANA-002-91. Unpublished study prepared by Pharmakon 

20-Apr1992 

96
Research International, Inc. 31 p. 

42289203 

Mallory, V. (1991) Primary Eye Irritation with Endothall Technical: Rabbit: Lab Project 

Number: PH 421-ANA-002-91. Unpublished study prepared by Pharmakon Research 

International, Inc. 35 p. 

20-Apr1992 

42289204 

Mallory, V. (1992) Primary Dermal Irritation Study with Endothall Technical: Rabbit: 

Lab Project Number: PH 420-ANA-002-91. Unpublished study prepared by Pharmakon 

Research International, Inc. 27 p. 

20-Apr1992 

42289205 

Saxena, A.; Marsh, S. ; Koebel, D. (1991) Photodegradation of carbon 14-Endothall in a 

Buffered Aqueous Solution Under Artificial Sunlight: Final Report: Lab Project Number: 

SC910024: BR-91-25. Unpublished study prepared by Battelle. 55 p. 

20-Apr1992 

42289206 

Zwick, T.; Kazee, B.; Marsh, S. (1990) Photodegradation of carbon 14 Endothall in 

Water Under Artificial Light: Final Report: Lab Project Number: SC890059. 

Unpublished study prepared by Battelle. 92 p. 

20-Apr1992 

42289207 

Saxena, A.; Zwick, T.; Marsh, S.; et al. (1991) Photodegradation of carbon 14-Endothall 

on Sandy Loam Soil Under Artificial Light: Final Report: Lab Project Number: 

SC890060: BR-90-02. Unpublished study prepared by Battelle. 67 p. 

20-Apr1992 

42327700 Atochem North America, Inc. (1992) Submission of Toxicity data in support of 

Reregistration for Endothall. Transmittal of 2 studies. 

26-May1992 

Bettencourt, M. (1992) Endothall Technical-Acute Toxicity to Bluegill Sunfish (Lepomis 

42327701 macrochirus) under Flow-through Conditions: Lab Project Number: 91-9-3917: 

12442.0591.6121.105. Unpublished study prepared by Springborn Laboratories, Inc. 62 

26-May1992 

p. 

Bettencourt, M. (1992) Endothall Technical-Acute Toxicity to Rainbow Trout 

42327702 (Oncorhynchus mykiss) Under Flow-through Conditions: Lab Project Number: 91-9-

3918: 12442.0591.6120.108. Unpublished study prepared by Springborn Laboratories, 

26-May1992 

Inc. 63 p. 

42359700 

Atochem North America (1992) Submission of Data in Support of Endothall Acid 

(Technical) as Required in the Reregistration DCI: Toxicology Studies. Transmittal of 2 

studies. 

17-Jun1992 

42359702 

McNamara, P. (1992) Endothall Technical--Acute Toxicity to Daphnids (Daphnids 

magna) Under Flow-through Conditions: Final Report: Lab Project Number: 91-10-3946: 

12442.0591.6122.115. Unpublished study prepared by Springborn Labs., Inc. 64 p. 

17-Jun1992 

42408700 Atochem North America, Inc. (1992) Submission of toxicity data in support of the data 

call-in for Endothall. Transmittal of 1 study. 

21-Jul1992 

42408701 

Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Endothall Technical in the 

Rat: Lab Project Number: 91-8355. Unpublished study prepared by Bio/dynamics, Inc. 

132 p. 

21-Jul1992 

42427900 Atochem North America, Inc. (1992) Submission of product chemistry data in support of 

the reregistration of endothall. Transmittal of 1 study. 

05-Aug1992 

42427901 

Douglass, M. (1992) Endothall--Analysis of Product Samples: Lab Project Number: 

4200-91-0279-AS: 4200-91-0279-AS-001. Unpublished study prepared by Ricerca, Inc. 

71 p. 

05-Aug1992 

42507300 ELF Atochem (1992) Submission of toxicity data to support endothall reregistration. 

Transmittal of 2 studies. 

10-Oct1992 

42507301 Pedersen, C.; Fletcher, D. (1992) Endothall Technical: Toxicity and Reproduction Study 10-Oct97
in Mallard Ducks: Lab Project Number: 89 DR 37. Unpublished study prepared by Bio­ 1992 

Life Associates, Ltd. 300 p. 

42507302 

Pedersen, C.; Fletcher, D.; Lesar, C. (1992) Endothall Technical: Toxicity and 

Reproduction Study in Bobwhite Quail: Lab Project Number: 89 QR 41. Unpublished 

study prepared by Bio-Life Associates, Ltd. 301 p. 

10-Oct1992 

42619200 Atochem North America, Inc. (1992) Submission of residue data in support of the data 

call-in for Endothall Acid (technical). Transmittal of 3 studies. 

08-Jan1993 

42619201 

Sanger, T. (1992) Nature of the Residue in Alfalfa: (carbon 14)-Endothall: Final Report: 

Lab Project Number: HWI 6120-154: BR-91-48. Unpublished study prepared by 

Hazleton Wisconsin, Inc. 108 p. 

08-Jan1993 

42619202 

Sanger, T. (1992) Nature of the Residue in Cotton: (carbon 14)-Endothall: Final Report: 

Lab Project Number: HWI 6120-152: BR-91-49. Unpublished study prepared by 

Hazleton Wisconsin, Inc. 138 p. 

08-Jan1993 

42619203 

Sanger, T. (1992) Nature of the Residue in Sugar Beets: (carbon 14)-Endothall: Final 

Report: Lab Project Number: HWI 6120-150: BR-91-50. Unpublished study prepared by 

Hazleton Wisconsin, Inc. 114 p. 

08-Jan1993 

42629700 Elf Atochem N.A., Inc. (1993) Submission of product chemistry data in support of the 

data call-in for Endothall Acid (technical). Transmittal of 1 study. 

21-Jan1993 

42629701 

Sweetapple, G. (1992) Endothall Acid Monohydrate, TG--Color, Physical State, Odor, 

Melting Point, Bulk Density, pH: Lab Project Number: 4200-92-0172-AS: 4200-92-

0172-AS-001. Unpublished study prepared by Ricerca, Inc. 36 p. 

21-Jan1993 

42641200 Atochem N.A., Inc. (1992) Supplemental Submission of environmental fate data to 

support the Endothall reregistration. Transmittal of 2 studies. 

27-Jan1993 

42641201 

Zwick, T.; Kazee, B.; Marsh, S. (1992) Photodegradation of (carbon 14)-Endothall in 

Water under Artificial Light: Amended Final Report: Lab Project Number: SC890059: 

N0758-4400. Unpublished study prepared by Battelle. 92 p. 

27-Jan1993 

42641202 

Saxena, A.; Zwick, T.; Marsh, S.; et al. (1992) Photodegradation of (carbon 14)-Endothall 

on Sandy Loam under Artificial Light: Amended Final Report: Lab Project Number: 

SC890060: BR-90-02. Unpublished study prepared by Battelle. 67 p. 

27-Jan1993 

42668000 Atochem North America (1993) Submission of product chemistry data in support of the 

data call-in for Endothall Acid (Technical). Transmittal of 1 study. 

17-Feb1993 

42668001 

Gallacher, A. (1993) Endothall Acid Monohydrate--Dissociation Constant: Lab Project 

Number: 4200-92-0133-AS: 4200-92-0133-AS-001. Unpublished study prepared by 

Ricerca, Inc. 54 p. 

17-Feb1993 

42776300 Elf Atochem North America, Inc. (1993) Submission of toxicity data in support of the 

reregistration DCI for Endothall Acid. Transmittal of 1 study. 

18-May1993 

42776301 

Trutter, J. (1993) Rat Developmental Toxicity Study with Disodium Salt of Endothall: 

Final Report: Lab Project Nu mber: 153-146. Unpublished study prepared by Hazleton 

Washington, Inc. 289 p. 

18-May1993 

42792700 Elf Atochem North America, Inc. (1993) Submission of metabolism data in response to 

DCI for Endothall Acid (Technical). Transmittal of 2 studies 

01-Jun1993 

42792701 

Sanger, T. (1993) Metabolism of (carbon 14)-Endothall in Lactating Goats: Final Report: 

Lab Project Number: HWI 6120-158: BR-91-52. Unpublished study prepared by 

Hazleton Wisconsin, Inc. 103 p. 

01-Jun1993 

98
42816600 Elf Atochem North America, Inc. (1993) Submission of residue data in response to DCI 

for reregistration of Endothall Acid (Technical). Transmittal of 1 study. 

01-Jun1993 

42816601 

Sanger, T. (1993) Metabolism of (carbon 14)-Endothall in Laying Hens: Final Report: 

Lab Project Numb er: HWI 6120-160: BR-91-51. Unpublished study prepared by 

Hazleton Wisconsin, Inc. 118 p. 

01-Jun1993 

42895200 Elf Atochem North America, Inc. (1993) Submission of Toxicology Data in Support of 

Endothall Acid as Required for Reregistration. Transmittal of 1 study. 

24-Aug1993 

Dionne, E. (1993) Endothall Technical--Acute Toxicity to Eastern Oyster (Crassostrea 

42895201 virginica) Under Flow-through Conditions: Final Report: Lab Project Number: 93-4-

4715: 12442.0591.6125.504. Unpublished study prepared by Springborn Laboratories, 

24-Aug1993 

Inc. 68 p. 

42914100 Elf Atochem North America, Inc. (1993) Submission of Acute Toxicology Data for 

Endothall Acid (Technical) in Support of Reregistration. Transmittal of 2 Studies. 

08-Sep1993 

Bettencourt, M. (1993) Endothall Technical-Acute Toxicity to Mysid Shrimp 

42914101 (Mysidopsis bahia) Under Flow-Through Conditions: Final Report: Lab Project Number: 

12442.0591.6124.515: 93-3-4711. Unpublished study prepared by Springborn Labs, Inc. 

08-Sep1993 

67 p. 

Bettencourt, M. (1993) Endothall Technical-Acute Toxicity to Sheepshead Minnow 

42914102 (Cyprinodon variegatus) Under Flow-Through Conditions: Final Report: Lab Project 

Number: 92-1-4901: 12442.0591.6123.505. Unpublished study prepared by Springborn 

08-Sep1993 

Labs, Inc. 65 p. 

43007800 Elf Atochem North America, Inc. (1993) Submission of Toxicology Data in Support of 

Endothall Data Call-in. Transmittal of 1 Study. 

15-Nov1993 

43007801 

Putt, A. (1993) Endothall Technical (Acid)--The Chronic Toxicity to Daphnia magna 

Under Flow-Through Conditions: Final Report: Lab Project Number: 92-11-4525: 

12442.0692.6148.130. Unpublished study prepared by Springborn Labs, Inc. 99 p. 

15-Nov1993 

43081900 Elf Atochem North America, Inc. (1993) Submittal of Corrosion Characteristics Data in 

Support of Reregistration of Endothall Acid Monohydrate. Transmittal of 1 study. 

11-Jan1994 

43081901 Sweetapple, G. (1993) Endothall Acid Monohydrate, TG--Corrosion Characteristics: Lab 

Project Number: 4200-92-0173-AS. Unpublished study prepared by Ricerca, Inc. 36 p. 

11-Jan1994 

43152100 Elf Atochem North America, Inc. (1994) Submission of toxicity data in support of 

reregistration for Endothall Acid Technical. Transmittal of 1 study. 

09-Mar1994 

43152101 

Trutter, J. (1993) Two-Generation Reproduction Study in Rats with Disodium Salt of 

Endothall: Final Report: Lab Project Number: 153/142. Unpublished study prepared by 

Hazleton Washington, Inc. 1479 p. 

09-Mar1994 

43167700 Elf Atochem North America, Inc. (1994) Submittal of Dietary Toxicity Data in Support 

of Reregistration of Endothall Acid. Transmittal of 2 studies. 

22-Mar1994 

43167701 

Pedersen, C.; Solatycki, A. (1994) Endothall Technical: 8-Day Acute Dietary LC 50 

Study in Bobwhite Quail: Lab Project Number: 106-011-01. Unpublished study prepared 

by Bio-Life Associates, Ltd. 96 p. 

22-Mar1994 

43167702 

Pedersen, C.; Solatycki, A. (1994) Endothall Technical: 8-Day Acute Dietary LC 50 

Study in Mallard Ducklings: Lab Project Number: 106-015-02. Unpublished study 

prepared by Bio-Life Associates, Ltd. 94 p. 

22-Mar1994 

43265000 Elf Atochem North America, Inc. (1994) Submission of product chemistry (stability) data 

in support of reregistration of Endothall Acid Monohydrate. Transmittal of 1 study. 

10-Jun1994 

99
43265001 Malone, S. (1994) Endothall Acid Monohydrate TG (B44-26-3): Stability: Lab Project 

Number: 4200/92/0184/AS. Unpublished study prepared by Ricerca, Inc. 56 p. 

10-Jun1994 

43295400 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data in Support of 

Endothall Reregistration. Transmittal of 1 Study. 

07-Jul1994 

Bettencourt, M. (1994) Endothall Technical (Acid)--The Toxicity to Fathead Minnow 

43295401 (Pimephales promelas) During an Early Life-stage Exposure: Final Report: Lab Project 

Number: 93-1-4567: 12442.0692.6149.120. Unpublished study prepared by Springborn 

07-Jul1994 

Labs, Inc. 84 p. 

43300700 Elf Atochem North America, Inc. (1994) Submission of Environmental Fate Data in 

Support of Endothall Reregistration. Transmittal of 1 Study. 

18-May1994 

43300701 

Sanger, T. (1994) (Carbon 14) -Endothall: Accumulation in Confined Rotational Crops 

(Greenhouse Study): Final Report: Lab Project Number: HWI 6120-148: BR-91-47: 

R149104. Unpublished study prepared by Hazleton Wisconsin, Inc. 240 p. 

18-May1994 

43327700 Elf Atochem North America, Inc. (1994) Submittal of Toxicity Data in Support of 

Reregistration for Endothall. Transmittal of 1 study. 

04-Aug1994 

43327701 

Armondi, S. (1994) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with 

Accelerate: Lab Project Number: PH-424-ANA-003-93. Unpublished study prepared by 

Pharmakon Research International, Inc. 107 p. 

04-Aug1994 

43339300 Elf Atochem North America, Inc. (1994) Submission of Product Chemistry Data in 

Support of Endothall Reregistration. Transmittal of 1 Study. 

16-Aug1994 

43339301 

Lorence, P. (1994) Endothall Acid Monohydrate, PAI-Solubility: Lab Project Number: 

4200-92-0135-AS: 4200-92-0135-AS-001. Unpublished study prepared by Ricerca, Inc. 

84 p. 

16-Aug1994 

43558200 Elf Atochem North America, Inc. (1995) Submission of Hazard to Non- target Organisms 

Data in Support of Endothall Reregistration. Transmittal of 2 Studies. 

24-Feb1995 

Rose, S.; Goin, L. (1994) Endothall Technical: 28-Day Dietary Toxicity and 

43558201 Reproduction Pilot Study in Mallard Ducks: Addendum: Diet Analyses: Final Report: 

Lab Project Number: 89 DRP 37: 33400. Unpublished study prepared by NPC, Inc.; 

24-Feb1995 

Columbia Labs, Inc.; and Bio-Life Associates, Ltd. 49 p. 

Rose, S.; Goin, L. (1994) Endothall Technical: Toxicity and Reproduction Study in 

43558202 Mallard Ducks: Addendum: Diet Analyses: Final Report: Lab Project Number: 89 DR 37: 

0660: 09356. Unpublished study prepared by NPC, Inc.; Columbia Labs, Inc.; and Bio24-Feb1995 

Life Associates, Ltd. 47 p. 

43558300 Elf Atochem North America, Inc. (1995) Submission of Toxicity Data in Support of the 

Endothall Registration Standard. Transmittal of 2 Studies. 

24-Feb1995 

Rose, S.; Goin, L. (1994) Endothall Technical: 28-Day Dietary Toxicity and 

43558301 Reproduction Pilot Study in Bobwhite Quail: Addendum: Diet Analyses: Final Report: 

Lab Project Numbers: BLAL 89 QRP 41: 33400: 153-144. Unpublished study prepared 

24-Feb1995 

by Columbia Labs, Inc.; NPC, Inc.; Bio-Life Associates, Ltd. 49 p. 

Rose, S.; Goin, L. (1994) Endothall Technical: Toxicity and Reproduction Study in 

43558302 Bobwhite Quail: Addendum: Diet Analyses: Final Report: Lab Project Numbers: BLAL 

89 QR 41: 0660: 09356. Unpublished study prepared by Columbia Lab, Inc.; NPC, Inc.; 

24-Feb1995 

Bio-Life Associates, Ltd. 47 p. 

43953100 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the 

Reregistration of Endothall and Salts. Transmittal of 1 Study. 

15-Mar1996 

100
43953101 

Guyton, B. (1996) Endothall: Magnitude of the Residue in Potato: Lab Project Number: 

BR-93-01: U:\ATOCHEM\ BR9301FR.DOC. Unpublished study prepared by McKenzie 

Laboratories, Inc. 315 p. 

15-Mar1996 

43975900 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the 

Reregis tration of Endothall, K-Salt. Transmittal of 1 Study. 

25-Mar1996 

43975901 

Guyton, B. (1996) Endothall: Magnitude of the Residue in Sugar Beets: Final Report: 

Lab Project Number: BR-93-02. Unpublished study prepared by Elf Atochem North 

America and Mckenzie Labs, Inc. 347 p. 

25-Mar1996 

44077800 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of 

Endothall and Salts Reregistration. Transmittal of 1 Study. 

07-Aug1996 

Sanger, T. (1996) Storage Stability Data for (carbon 14) Endothall Plant Metabolism 

44077801 Studies (Addenda to MRID #'s 42619201, 42619202, 42619203): Lab Project Number: 

HWI 6120-150: HWI 6120-152: HWI 6120-154. Unpublished study prepared by 

07-Aug1996 

Hazleton Wisconsin, Inc. 8 p. 

44106300 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the 

Reregistration for Endothall and Salts. Transmittal of 1 Study. 

10-Sep1996 

44106301 

Sharp, J. (1996) Endothall: Storage Stability of Residues in Cottonseed: Lab Project 

Number: BR-93-30: 30-93: PRM-047. Unpublished study prepared by Elf Atochem 

North America, Inc. and McKenzie Laboratories, Inc. 170 p. 

10-Sep1996 

44263500 Elf Atochem North America, Inc. (1997) Submission of Metabolism and Residue Data in 

Support of the Reregistration of Endothall and Salts. Transmittal of 8 Studies. 

29-Apr1997 

44263501 

Bounds, S. (1997) Endothall: Metabolism and Excretion Study in the Rat: Final Report: 

Lab Project Number: KP-96-02: 96/1290: 96/EFM001/1290. Unpublished study prepared 

by Huntingdon Life Sciences Ltd. 182 p. 

29-Apr1997 

44320400 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of 

Petition for Tolerance for Endothall on Apples. Transmittal of 3 Studies. 

03-Jul1997 

44320403 Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number: 

FQPA 697E. Unpublished study prepared by Elf Atochem N.A., Inc. 42 p. 

03-Jul1997 

44578400 Elf Atochem North America, Inc. (1998) Submission of Environmental Fate Data in 

Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 

11-Jun1998 

44578401 

Mao, J. (1997) Endothall Amine Salt--Determination of pH Dependent Hydrolysis: Lab 

Project Number: 12442.0396.6209.715: KP-96-01: 96-6-6537. Unpublished study 

prepared by Springborn laboratories, Inc. 79 p. 

11-Jun1998 

44608600 Elf Atochem North America, Inc. (1998) Submission of Residue Chemistry Data in 

Support of the Reregistration of Endothall Acids and Salts. Transmittal of 1 Study. 

16-Jul1998 

44608601 

Fomenko, J. (1998) Evaluation of Endothall Through the FDA Multiresidue Methods: 

Lab Project Number: A036.50: KP -97-18. Unpublished study prepared by Maxim 

Technologies, Inc. 63 p. {OPPTS 860.1360} 

16-Jul1998 

44820100 

Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, Risk 

Assessment and Exposure Data in Support of the Reregistration of Endothall Acid and 

Salts. Transmittal of 4 Studies. 

05-May1999 

Keckemet, O.; Sharp, J. (1999) Historical Aquatic Residue and Dissipation Data for 

44820101 Endothall Aquatic Products Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic 

Algicide and Herbicide: Lab Project Number: KP-99-02: WT-86-C-11. Unpublished 

05-May1999 

study prepared by Elf Atochem. 316 p. {OPPTS 860.1400} 

101
Dionne, E.; Sharp, J.; Formella, T. (1999) Dipotassium Salt of Endothall: A Freshwater 

44820102 Fish and Shellfish Magnitude of Residues Study in a Static Aquatic System: Lab Project 

Number: KP-97-14: 52897/171.4/FIFRA: EN1115.95. Unpublished study prepared by Elf 

05-May1999 

Atochem and ABC Laboratories, Inc. 213 p. {OPPTS 860.1400} 

44820103 

Biever, R. (1998) Hydrothol 191: An Aquatic Dissipation Study for Aquatic Non-Crop 

Uses: Final Report: Lab Project Number: KP-96-14: 98-1-7215: 12442-0896-6214-330. 

Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 164 p. 

05-May1999 

44820104 

Giddings, J. (1999) Ecological Risk Assessment of Aquatic Herbicides Containing 

Endothall: Final Report: Lab Project Number: KP-98-31: 98-11-7564: 12442-0898-6271-

251. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 64 p. 

05-May1999 

44828800 

Elf Atochem North America (1999) Submission of Environmental Fate Data in Support 

of the Reregistration of Endothall Acid and Salts Containing Products Aquathol K and 

Hydrothal 191. Transmittal of 2 Studies. 

05-May1999 

Singh, P.; Ritter, A.; Sharp, J. et al. (1999) Aquatic Dissipation Modeling of Endothall 

44828801 Acid: Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: 

Lab Project Number: ATO KP-97-16: WEI 286.01. Unpublished study prepared by 

05-May1999 

Waterborne Environmental, Inc. 363 p. 

Williams, W.; Ritter, A.; Sharp, J. et al. (1999) An Evaluation of the Aquatic Dissipation 

44828802 of Endothall Aquatic Product: Aquathol, K Aquatic Herbicide and Hydrothol 191 Aquatic 

Algicide and Herbicide: Lab Project Number: ATOKP-98-32: WEI-286.06. Unpublished 

05-May1999 

study prepared by Waterborne Environmental, Inc. 69 p. 

44856300 

Elf Atochem North America, Inc. (1999) Submission of Toxicity, Residue Chemistry, 

Risk Assessment and Exposure Data in Support of the Petition for Tolerance of Endothall 

in/on Edible Fish. Transmittal of 1 Study. 

21-Jun1999 

44856301 Piccirillo, V. (1999) FQPA Supplemental Information on Endothall: Lab Project Number: 

FQPA 499E. Unpublished study prepared by Elf Atochem North America, Inc. 35 p. 

21-Jun1999 

44949200 Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the 

Reregistration of Endothall and its Salts. Transmittal of 2 Studies. 

20-Oct1999 

Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 96-Hour 

44949201 Toxicity Test with the Freshwater Diatom (Navicula pelliculosa): Final Report: Lab 

Project Number: 299A-102. Unpublished study prepared by Wild life International Ltd. 38 

20-Oct1999 

p. {OPPTS 850.5400} 

Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 96-Hour 

44949202 Toxicity Test with the Freshwater Alga (Anabaena flos-aquae): Final Report: Lab Project 

Number: 299A-101. Unpublished study prepared by Wildlife International Ltd. 36 p. 

20-Oct1999 

{OPPTS 850.5400} 

44949400 

Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, and 

Toxicity Data in Support of the Reregistration of Endothall Acid & Salts. Transmittal of 3 

Studies. 

20-Oct1999 

44949401 

Atkins, R.; Peel, D.; Marsh, D. (1999) Aerobic Soil Metabolism of (carbon-14) 

Endothall: Lab Project Number: 1134: 2045: KP-97-24. Unpublished study prepared by 

PTRL East, Inc. 167 p. 

20-Oct1999 

44949402 

Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 7-Day Toxicity 

Test with Duckweed (Lemna gibba G3): Final Report: Lab Project Number: 299A-105. 

Unpublished study prepared by Wildlife International Ltd. 34 p. {OPPTS 850.4400} 

20-Oct1999 

44949403 Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 7-Day Toxicity 20-Oct102
Test with The Freshwater Alga (Selenastrum capricornutum): Final Report: Lab Project 1999 

Number: 299A-103. Unpublished study prepared by Wildlife International Ltd. 36 p. 

{OPPTS 850.5400} 

44976700 

Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the 

Reregistration of Endothall Acids and Salts Containing Product Hydrothol 191. 

Transmittal of 1 Study. 

20-Oct1999 

Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191: A 96-Hour Toxicity Test with 

44976701 the Marine Diatom (Skeletonema costatum): Final Report: Lab Project Number: 299A104. Unpublished study prepared by Wildlife International , Ltd. 38 p. {OPPTS 

20-Oct1999 

850.5400} 

45034700 IR-4 Project (2000) Submission of Residue Chemistry Data in Support of the Petition for 

Tolerance of Endothall in/on Hops. Transmittal of 1 Study. 

24-Jan2000 

45034701 

Arsenovic, M. (2000) Endothall: Magnitude of the Residue on Hops: Lab Project 

Number: 06575: 06575.97-CAR07: 06575. 97-ID22. Unpublished study prepared by IR-4 

Project. 125 p. {OPPTS 860.1500} 

24-Jan2000 

45039500 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in 

Support of the Reregistration of Endothall and Endothall Salts. Transmittal of 1 Study. 

28-Jan2000 

45039501 

Toth, J. (1999) Immunochemical Method for Residues of Endothall in Water: Lab Project 

Number: KP-023-00. Unpublished study prepared by Elf Atochem North America, Inc. 

74 p. {OPPTS 850.7100} 

28-Jan2000 

45088200 US EPA (2000) Submission of Toxicity and Environmental Fate Data in Support of the 

Registration of various Triazine and other Pesticides. Transmittal of 32 Studies. 

12-Apr2000 

45088229 Hiltibran, R. (1967) Effect of Some Herbicides on Fertilized Fish Eggs and Fry. Trans. 

Am. Fish. Soc. 96:414-416. 

12-Apr2000 

45146300 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in 

Support of the Reregistration of Endothall Acid and its Salts. Transmittal of 2 Studies. 

19-Jun2000 

45146301 

Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potatoes: 

Final Report: Lab Project Number: KP-98-22: 22A-98: 22B-98. Unpublished study 

prepared by Elf Atochem North America, Inc. 202 p. {OPPTS 860.1500} 

19-Jun2000 

Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potato 

45146302 Processing Fractions: Final Report: Lab Project Number: KP-98-23: 44884: 23A-98. 

Unpublished study prepared by Elf Atochem North America, Inc. 162 p. {OPPTS 

19-Jun2000 

860.1520} 

45156000 Elf Atochem North America, Inc. (2000) Submission of Residue Data in Support of the 

Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 

29-Jun2000 

45156001 

Gresham, M. (2000) Analysis for Residues of Endothall Using HPLC-MSD: Lab Project 

Number: KP-98-49: 44280. Unpublished study prepared by ABC Labs., Inc. 123 p. 

{OPPTS 860.1340} 

29-Jun2000 

45219000 

Elf Atochem North America, Inc. (2000) Submission of Toxicity, Residue Chemistry, 

Environmental Fate, Risk Assessment and Exposure Data in Support of the Petition for 

Tolerance of Endothall in/on Apples and Cotton. Transmittal of 2 Studies. 

26-Sep2000 

45219001 

Davis, C. (2000) FQPA Supplemental Information on Endothall Petition 7F4868: 

Endothall on Apples: Lab Project Number: FQPA 697F. Unpublished study prepared by 

Elf Atochem North America, Inc. 37 p. 

26-Sep2000 

45219002 Davis, C. (2000) FQPA Supplemental Information on Endothall Petition 7F4867: 26-Sep103
Endothall on Cottonseed: Lab Project Number: FQPA 697E. Unpublished study prepared 2000 

by Elf Atochem North America, Inc. 41 p. 

46421400 Cerexagri, Inc. (2004) Submission of Toxicology, Residue, Exposure and Risk Data in 

Support of the Petition for Tolerance of Endothall in Fish. Transmittal of 3 Studies. 

08-Dec2004 

46421401 

Eickhoff, J. (2004) Endothall: Acute and Chronic Dietary Exposure and Risk Assessment. 

Project Number: ENDOTHALL/2004/1. Unpublished study prepared by Toxcel LLC. 41 08-Dec2004 

p. 

46421402 

Petty, D. (2004) Freshwater and Estuarine Finfish and Shellfish Consumption in the 

United States: Endothall. Project Number: NDR200403. Unpublished study prepared by 

NDR Research. 17 p. 

08-Dec2004 

Brookey, F. (2004) Independent Laboratory Valid ation of the Residue Analytical 

46421403 Method: "Analysis for Residues of Endothall Using HPLC-MSD", Method No. KP218R0. Project Number: ML/04/1139/CRX, KP/2004/11, KP/218RO. Unpublished study 

08-Dec2004 

prepared by Morse Laboratories. 197 p. 

92057000 Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Endothall. 25-May1990 

92057001 

Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

00072455. Endothall Technical--Single Dose Oral LD50 Value to Bobwhite Quail: 

Project W-910. Prepared by Hazleton Laboratories America, Inc. 10 p. 

25-May1990 

92057002 

Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

00035237. Hydrothol 191 - Acute Oral LD50 Test - Bobwhite Quail: Project No. 110­

115. Prepared by Wildlife International Ltd. 11 p. 

25-May1990 

92057003 

Shellenberger,T (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

00084613. Primary Eye Irritation of Endothal Granular to Rabbits: Project No. 867431. 

Prepared by Hazleton Laboratories America, Inc. 12 p. 

25-May1990 

92057004 

Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

40109204. Primary Dermal Irritation Study of Endothall Pelleted with the Rabbit: Project 

No. 480-2538. Prepared by American Biogenics Corporation. 8 p. 

25-May1990 

Plankenhorn, L. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

92057005 41040301. Combined Chronic Toxicity and Carcinogenicity Study of Disodium 

Endothall in Rats: Project HLA 6120 -110. Prepared by Hazleton Laboratories America, 

25-May1990 

Inc. 11 p. 

92057006 

Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

40745202. Chronic Feeding in the Rodent Endothall in the Non-Rodent: Project IRI 

632934. Prepared by Inveresk Research International. 12 p. 

25-May1990 

92057007 

Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

40685301. Oncogenicity Feeding Study of Disodium Endothall in Mice: Project No. 

WIL-75009. Prepared by WIL Research Laboratories. 15 p. 

25-May1990 

92057008 

Plankenhorn, L. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

00069054. Activity of the Endothall in the Salmonella/Microsomal Assay for Bacterial 

Mutagenicity: Project MA 1604.102. Prepared by Microbiological Associates. 8 p. 

25-May1990 

92057009 

Plankenhorn, L. (1990) Agchem Division-Pennwalt Corp. Phase 3 Reformat of MRID 

00069054. Activity of Endothall in the Salmonella/Microsomal Assay for Bacterial 

Mutagenicity: Project MA 1604.102. Prepared by Microbiological Associates. 17 p. 

25-May1990 

92057999 Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Endothall. 25-May104
Correspondence and Supporting Material. 1990 

105
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05-Jan1968 

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32901 

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35236 Pennwalt Corporation (1975) Fish and Wildlife Safety. (Unpublished study received Jan 5, 

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05-Jan1978 

Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Eight-Day Dietary LC50--Bobwhite 

35238 Quail: Project No. 110-111. (Unpublished study received Jan 5, 1978 under 1F1105; 

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05-Jan1978 

35427 Pennwalt Corporation Product Chemistry: Data Requirements. (Unpublished study received 

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05-Jan1978 

35433 Pennwalt Corporation (1977) Stability of the Dipotassium Salt of Endothall. (Unpublished 

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05-Jan1978 

35442 

Pennwalt Corporation (1974) Results of Residue Determinations: Disappearance of 

Endothall in Water. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-

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05-Jan1978 

35443 

Pennwalt Corporation (1974) Results of Residue Determinations: Fish and Other Aquatic 

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1F1105; CDL:096703-T) 

05-Jan1978 

35453 Pennwalt Corporation (1954) Toxicology:Endothall. (Unpublished study received Jan 5, 

1978 under 1F1105; CDL:096703-AE) 

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Carlson, R.E.; Sandeno, J.L. (1970) Effect of Endothall on the Growth of Several Fungi. 

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05-Jan1978 

Watson, J.D. (1970) The Results of Tests on the Amount of Residue Remaining including a 

36531 Description of the Analytical Method Used:Endothall. (Unpublished study received Jan 5, 

1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

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Watson, J.D. (1972) The Results of Tests on the Amount of Residue Remaining, Including 

36532 a Description of the Analytical Method Used:Endothall. (Unpublished study received Jan 5, 

1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

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Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, Including 

36533 a Description of the Analytical Methods Used:Endothall. (Unpublished study received Jan 

5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

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Serns, S.L. (1977) Effects of Dipotassium endothall on rooted aquatics and adult and first 05-Jan36536 generation bluegills. Water Re- sources Bulletin 13(1):71-80. (Also in unpublished 

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1978 

26-OctDiv., King of Prussia, Pa.; CDL:096704-K) 1978 

36537 

Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, Including 

a Description of the Analytical Method Used:Endothall. (Unpublished study received Jan 5, 

1978 under 1F1105; CDL:096704-L) 

05-Jan1978 

36539 

Miller, H. (1975) Phytotoxicity: Phototoxicity to Irrigated Crops. (Unpublished study 

received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of 

Prussia, Pa.; CDL: 096704-N) 

05-Jan1978 

36543 

Latven, A.R. (1975) Aquathol K (N.B. 58-196-4). (Unpublished study received Jan 5, 1978 

under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 

Agchem Div., King of Prussia, Pa.; CDL:096704 -S) 

05-Jan1978 

36545 

Latven, A.R. (1975) Aquathol Granular (N.B. 58-196-7). (Unpublished study received Jan 

5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt 

Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-V) 

05-Jan1978 

Latven, A.R. (1976) Endothall Products, Dermal Toxicity after Limited Exposure. 

36549 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology 

Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 

05-Jan1978 

096704-AB) 

Paa, H. (1976) Report to Pennwalt Corporation: Acute Dermal Toxicity Study with 

36556 Herbicide 273 in Albino Rabbits: IBT No. 8530- 08497. (Unpublished study received Jan 5, 

1978 under 1F1105; prepared by Industrial Bio-Test Laboratories, Inc., submitted by 

05-Jan1978 

Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704-AI) 

Wise, M.T. (1977) Acute Inhalation Toxicity of a) Aquathol K (N.B. 77-100-4) b) 26-JulHydrothol 191 Liquid (N.B. 77-100-2) c) Hydrothol 47 Liquid (N.B. 77-100-3) d) Aquathol 1977 

36561 (N.B. 77-99-7) e) Des-I-Cate Accelerate (N.B. 77-99-6) f) Knox-Out 2 FM (N.B. 4414-94): 

Laboratory Nos. a) 7E-5660 b) 7E-5665 c) 7E-5670 d) 7E-5675 e) 7E-5680 f) 7E-5685. 

04-Oct1977 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, 05-JanInc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-AO) 1978 

36566 Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Aquathol K (N.B. 77-100-4) on the 

Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5658. (Unpublished study 

05-Jan1978 

107
received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by 

Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-AT) 

Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Aquathol K 

36567 

(N.B. 77-100-4) on Abraded and Non-abraded Skin of New Zealand Albino Rabbits: 

Laboratory No. 7E-5659. (Unpublished study received Jan 5, 1978 under 1F1105; prepared 

by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div.; King of Prussia, 

05-Jan1978 

Pa.; CDL: 096704-AU) 

36568 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5656. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, 

Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704-AW) 

05-Jan1978 

Pierre, F.S.; Parke, G.S.E. (1977) Report : A Primary Dermal Irritation Study of Aquathol 

36573 

Granular (N.B. 77-99-4) on Abraded and Non-abraded Skin of New Zealand Albino 

Rabbits: Laboratory No. 7E-5689. (Unpublished study received Jan 5, 1978 under 1F1105; 

prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King 

05-Jan1978 

of Prussia, Pa.; CDL: 096704-BB) 

Becker, J.; Parke, G.S.E. (1977) Report; The Effects of Aquathol Granular (N.B. 77-99-4) 

36574 on Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5688. (Unpublished 

study received Jan 5, 1980 under 1F1105; prepared by Cannon Laboratories, Inc., submitted 

05-Jan1978 

by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-BC) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Aquathol Granular 

36575 (N.B. 77-99-4) on New Zealand Albino Rabbits: Laboratory No. 7E-5687. (Unpublished 

study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted 

05-Jan1978 

by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-BD) 

36576 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5686. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, 

Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704-BE) 

05-Jan1978 

Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77-99-4) 2. 

36592 

Hydrothol 191 Granular (N.B. 77- 99-2) 3. Hydrothol 47 Granular (N.B. 77-99-3) 4. 

Hydout (N.B. 77-99-5): Laboratory Nos. 1. 7E-5690 2. 7E-5695 3. 7E-5700 4. 7E-5705. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, 

05-Jan1978 

Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704-BU) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Aquathol K (N.B. 77­

37847 100-4) on New Zealand Albino Rabbits: Laboratory No. 7E-5657. (Unpublished study 

received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by 

05-Jan1978 

Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704-AV) 

40959 

Eibert, J., Jr. (1966) Acute Oral Toxicity (LD50) Study in Rats: S.A. No. 106319. 

(Unpublished study received Apr 10, 1966 under 6G0503; prepared by Scientific 

Associates, Inc., submitted by Pennwalt Chemical Corp., Bryan, Tex.; CDL:090587-B) 

10-Apr1966 

40984 

Pennsalt Chemical Corporation (1964) Analysis of Endothall in Water by Gas-Liquid 

Chromatography. Method dated Apr 27, 1964. (Unpublished study received Apr 10, 1966 

under 6G0503; CDL: 090587-AB) 

10-Apr1966 

Davis, J.T.; Hughes, J.S. (1963) Further observations on the toxicity of commercial 

41149 herbicides to bluegill sunfish. Proceedings of the Southern Weed Control Conference:337-

340. (Also n unpublished submission received on unknown date under 8F0660; submitted 

by Dow Chemical U.S.A., Midland, Mich.; CDL:094930-M) 

46269 Swabey, Y.H.; Schenk, C.F. (1963) Report on Algaecides and Aquatic Herbicides. (Ontario, 

Water Resources Commission, Laboratory Division, Biology Branch, unpublished study; 

12-Jan1965 

108
CDL:107773-B) 14-Apr1966 

48110 

Davis, J.T.; Hughes, J.S. (1963) Further Observations on the Toxicity of Commercial 

Herbicides to Bluegill Sunfish. (Louisiana, Wildlife and Fisheries Commission, 

unpublished study; CDL: 241577-R) 

02-Jan1980 

Schreck, C.B.; Corning, R.V.; Berry, C.R.; et al. (1974) Aquatic Plant Control Using 

48767 

Herbicides in a Large Potable Water Supply Reservoir: Contract No. DACW65-74-C-0013. 

Annual report for the period Jul 1, 1973--Jun 30, 1974. (Incomplete; Virginia Polytechnic 

Institute and State Univ., Dept. of Fisheries and Wild- life Sciences for U.S. Dept. of the 

22-Aug1977 

Army, Corps of Engineers, unpublished study; CDL:231436-C) 

Berry, C.R. (1974) The Toxicity of Diquat and Endothal to Mammals and Fish: Contract 

48768 No. DACW65-74-C-0013. (Virginia Polytechnic Institute and State Univ., Dept. of 

Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Corps of Engineers, 

22-Aug1977 

unpublished study; CDL:231436-D) 

Berry, C.R. (1974) Acute Toxicity of Diquat, Endothal, and a Mixture of the Two to 

48769 Bluegill Sunfish: Contract No. DACW65-74-C- 0013. (Virginia Polytechnic Institute and 

State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Corps of 

22-Aug1977 

Engineers, unpublished study; CDL:231436-E) 

Berry, C.R. (1974) Effect of Diquat and Endothall Separately and Combined on Bluegill 

48770 Ventilation Rate: Contract No. DACW65-74- C-0013. (Virginia Polytechnic Institute and 

State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Corps of 

22-Aug1977 

Engineers, unpublished study; CDL:231436-F) 

49752 Pennwalt Corporation (1976) Residue Results. (Unpublished study received Feb 14, 1977 

under 4581-223; CDL:228035 -A) 

14-Feb1977 

49958 

Pennwalt Corporation (1975) Toxicity of Rabbits to Aquathol K and Hydrothol 47. 

(Compilation; unpublished study received Oct 5, 1976 under 4581-173; submitted by 

Pennwalt Corp., Philadelphia, Pa.; CDL:226503-C) 

05-Oct1976 

56036 

White, R.L.; Bounds, R.L.; Lowman, F.G.; et al. (1967) Experimental Control of 

Submerged Vegetation in Clear Water Lakes: Federal Aid Project No. F-2-R-14. (Texas, 

Parks and Wildlife Dept., Wildlife Services, unpublished study; CDL:132475-A) 

25-Jun1971 

56037 

Crabtree, J.E.; Lewis, L.D.; Singleton, J.R.; et al. (1967) Lake Marvin Aquatic Weed 

Control: Federal Aid Project No. F-15-D-8. (Texas, Parks and Wildlife Dept., Wildlife 

Services, unpublished study; CDL:132475-E) 

25-Jun1971 

58568 

Pennwalt Corporation Endothall Technical. Tacoma, Wash.: Pennwalt. (Product data 

bulletin no. 13c; also in unpublished submission received Feb 1, 1975 under 3F1416; 

CDL:093785-D) 

01-Feb1975 

Imlay, P. (1978) Report: The Acute Dermal LD50 of Disodium endothall on New Zealand 

58720 Albino Rabbits: Laboratory No. 7E-9262. (Unpublished study received Oct 26, 1978 under 

4581-282; pre - pared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., 

26-Oct1978 

Philadelphia, Pa.; CDL:235435-B) 

Imlay, P. (1978) Report: The Acute Dermal LD50 of Dipotassium endothall on New 

58721 Zealand Albino Rabbits: Laboratory No. 7E-9263. (Unpublished study received Oct 26, 

1978 under 4581 -282; pre- pared by Cannon Laboratories, Inc., submitted by Pennwalt 

26-Oct1978 

Corp., Philadelphia, Pa.; CDL:235435-C) 

Anon. (1966) Summary of Toxicity Studies with Endothal Formulations on Animals. 

61097 (Unpublished study received on unknown date under unknown admin. no.; CDL:109 C890­

A) 

109
61605 Anon. (1967) Acute Oral LDI50 Data for Aquatic Herbicides. (Un - published study 

received Nov 18, 1968 under unknown admin. no.; CDL:109792-A) 

18-Nov1968 

Latven, A.R. (1975) Toxicology Report for Pennwalt Agchem Division: Aquathol K (N.B. 

61921 58-196-4). (Unpublished study received Oct 5, 1976 under 4581-174; prepared by 

Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

05-Oct1976 

CDL:227610-E) 

71130 

Pennwalt Corporation (1979) Fish and Wildlife Safety Summary. Summary of studies 

244131-B through 222131-R. (Unpublished study received Jan 23, 1981 under 4581-174; 

CDL:244131-A) 

23-Jan1981 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Bluegill 

71134 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506-41-16. (Unpublished 

study received Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted 

23-Jan1981 

by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-F) 

Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid 

71138 

Equivalent Lot No. ACC-06M8-04, NB84-5-10 to the Water Flea, Daphnia magna Straus: 

UCES Project No. 11506-41-14. (Unpublished study received Jan 23, 1981 under 4581­

174; pre - pared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; 

23-Jan1981 

CDL:244131-J) 

Morton, H.L.; Moffett, J.O.; MacDonald, R.H. (1972) Toxicity of herbicides to newly 23-Jan71149 emerged honeybees. Environmental Entomology 1(1):102-104. (also in unpublished 

submission received Jan 23, 1981 under 4581-04; submitted by Pennwalt Corp., 

1981 

23-OctPhiladelphia, Pa.; CDL:244128-A) 1981 

71445 

Landskov, A.O. (1981) Letter sent to Letha Coenen dated Feb 23, 1981: Compatibility--

herbicide 273 tank mixes: Project No. WT-2- 81. (Unpublished study received Mar 25, 

1981 under 4581 -223; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244661-A) 

25-Mar1981 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Bluegill 

72457 Sunfish, Lepomis macrochirus~Rafinesque: UCES Project No. 11506-41-16. (Unpublished 

study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by 

23-Jan1981 

Pennwalt Corp., Philadelphia, Pa.; CDL:099883-F) 

74308 

Pennwalt Corporation (1980) Efficacy of Various Herbicides--Sugar- beet. (Compilation; 

unpublished study received Mar 23, 1981 under ND 81/1; submitted by North Dakota, State 

Laboratories & Consumer Affairs for Pennwalt; CDL:244874-A) 

23-Mar1981 

74309 

Pennwalt Corporation (1976) Residue Study-Sugar Beet. (Compilation; unpublished study 

received Mar 23, 1981 under ND 81/1; submitted by North Dakota, State Laboratories & 

Consumer Affairs for Pennwalt; CDL:244874-B) 

23-Mar1981 

Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology reports 

78180 on seven products. (Unpublished study received Jan 5, 1978 under 4581-174; prepared by 

Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

05-Jan1978 

CDL:232580-B) 

Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Aquathol K (N.B. 

78183 58-196-4). (Unpublished study received Jan 5, 1978 under 4581-174; prepared by 

Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 

05-Jan1978 

232580-E) 

Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Aquathol Granular 

78186 (N.B. 58-196-7). (Unpublished study received Jan 5, 1978 under 4581-174; prepared by 

Pharmacology Re - search, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

05-Jan1978 

CDL:232580-H) 

110
Latven, A.R. (1976) Toxicology Report for Pennwalt, Agchem Division: Endothall 

78192 Products, Dermal Toxicity after Limited Expo- sure. (Unpublished study received Jan 5, 

1978 under 4581 -174; prepared by Pharmacology Research, Inc., submitted by Pennwalt 

05-Jan1978 

Corp., Philadelphia, Pa.; CDL:232580-O) 

Paa, H. (1976) Report to Pennwalt Corporation: Acute Dermal Toxicity Study with 

78198 Herbicide 273 in Albino Rabbits: IBT No. 8530- 08497. (Unpublished study received Jan 5, 

1978 under 4581 -174; prepared by Industrial Bio -Test Laboratories, Inc., submitted by 

05-Jan1978 

Pennwalt Corp., Philadelphia, Pa.; CDL:232580-V) 

Wise, M.T. (1977) Acute Inhalation Toxicity of Aquathol K (N.B. 77-100-4); Hydrothol 

191 Liquid (N.B. 77-100-2); Hydrothol 47 Liquid (N.B. 77-100-3); Aquathol (N.B. 77-99-

78202 7); Des-i-cate Accelerate (N.B. 77-99-6); Knox- out 2 FM (N.B. 4414-94): Laboratory Nos. 

7E-5660; 7E-5665; 7F-5670; 7E-5675; 7E-5680; 7E-5685. (Unpublished study received Jan 

05-Jan1978 

5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt 

Corp., Philadelphia, Pa.; CDL: 232580-AB) 

St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Aquathol K (N.B. 77-100-4) on 

78207 the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5658. (Unpublished 

study received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., 

05-Jan1978 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-AG) 

St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Aquathol 

78208 

K (N.B. 77-100-4) on Abraded and Non-abraded Skin of New Zealand Albino Rabbits: 

Laboratory No. 7E-5659. (Unpublished study received Jan 5, 1978 under 4581-174; 

prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

05-Jan1978 

CDL:232580-AH) 

78209 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Aquathol K: Lab No. 7E5656. (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, PA; CDL:232580-AJ) 

05-Jan1978 

St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Aquathol 

78214 

Granular (N.B. 77-99-4) on Abraded and Non-abraded Skin of New Zealand Albino 

Rabbits: Laboratory No. 7E-5689. (Unpublished study received Jan 5, 1978 under 4581­

174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, 

05-Jan1978 

Pa.; CDL:232580-AO) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Aquathol Granular 

78215 (N.B. 77-99-4) on New Zealand Albino Rabbits: Laboratory No. 7E-5687. (Unpublished 

study received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., 

05-Jan1978 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-AQ) 

78216 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5686. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-AR) 

05-Jan1978 

Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77-99-4); 2. 

78610 

Hydrothol 191 Granular (N.B. 77-99-2); 3. Hydrothol Granular (N.B. 77-99-3); 4. Hydout 

(N.B. 77-99-5): Laboratory Nos. 7E-5690; 7E- 5695; 7E-5700; 7E-5705. (Unpublished 

study received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratorie s, Inc., 

05-Jan1978 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BH) 

80437 

Pennsalt Chemicals Corporation (1954) Full Reports of Investigations Made with Respect 

to the Safety of the Product. (Unpublished study received Feb 4, 1966 under 6G0503; 

CDL:090585-B) 

04-Feb1966 

10-Jun1966 

81397 Pennwalt Corporation (1966) Toxicological Investigations, Mammals: Summary. Summary 14-Apr111
of studies 051133-B through 051133-M and 051133-R. (Unpublished study received Apr 1966 

14, 1966 under 4581- 70; CDL:051133-A) 

81407 

Eibert, J., Jr. (1966) Acute Oral Toxicity (LDI50) Study in Rats: S.A. No. 106319. 

(Unpublished study received Apr 14, 1966 under 4581-70; prepared by Scientific 

Associates, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:051133-K) 

14-Apr1966 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Rainbow Trout, 

83025 Salmo gairdneri Richardson: UCES Project No. 11506-41-15. (Unpublished study received 

Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted by Pennwalt 

23-Jan1981 

Corp., Philadelphia, Pa.; CDL:244131-C) 

83032 Pennwalt Corporation (1979) Fish and Wildlife Safety: Summary. (Unpublished study 

received Mar 25, 1981 under 4581-223; CDL: 244664-A) 

25-Mar1981 

25-Mar83033 Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 

244662-B. (Unpublished study received Mar 25, 1981 under 4581-223; CDL:244662-A) 

1981 

14-Sep1981 

83034 

Pennwalt Corporation (1979) Drift of Endothall Sprays and Their Phytotoxic Effects on 

Non-target Plant Species: Project No. WT- 8-78. (Unpublished study received Mar 25, 1981 

under 4581-223; CDL:244662 -B) 

25-Mar1981 

Vilkas, A.J.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Rainbow Trout, 

83106 Salmo gairdneri Richardson: UCES Project No. 11506-41-15. (Unpublished study received 

Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt 

23-Jan1981 

Corp., Philadelphia, Pa.; CDL:099883-C) 

Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid 

83107 

Equivalent Lot No. ACC-06M8-04, NB84-5-10 to the Water Flea, Daphnia magna straus: 

UCES Project No. 11506-41-14. (Unpublished study, including letter dated Feb 7, 1980 

from O. Keckemet to Agchem File, received Jan 23, 198 1 under 1F1105; prepared by 

23-Jan1981 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-J) 

Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid 

84150 

Equivalent Lot No. ACC-06M8-04, NB84-5-10 to the Water Flea, Daphnia magna straus: 

UCES Project No. 11506-41-14. (Unpublished study received Jan 23, 1981 under 4581­

282; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; 

23-Jan1981 

CDL:244122-J) 

84601 Pennwalt Corporation (19) Product Chemistry: Data Requirements. (Unpublished study 

received Sep 14, 1981 under 4581 -349; CDL: 246016-A) 

14-Sep1981 

84604 

Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012-J 

through 246012-P. (Unpublished study received Sep 14, 1981 under 4581-349; 

CDL:246012-B) 

14-Sep1981 

84605 Pennwalt Corporation (1975) Sub-acute Studies: Endothall. (Un- published study received 

Sep 14, 1981 under 4581-349; CDL: 246012-C) 

14-Sep1981 

84608 Pennwalt Corporation (1979) Oncogenicity Studies: Endothall. (Unpublished study received 

Sep 14, 1981 under 4581-349; CDL: 246012-F) 

14-Sep1981 

84612 

Ralston Purina Company (1981) Aquathol Granular Aquatic Herbicide: RT Lab No. 

844059. (Unpublished study received Sep 14, 1981 under 4581-349; submitted by Pennwalt 

Corp., Philadelphia, Pa.; CDL:246012-J) 

14-Sep1981 

84614 Ralston Purina Company (1981) Aquathol Granular Aquatic Herbicide: RT Lab No. 

844057. (Unpublished study received Sep 14, 1981 under 4581-349; submitted by Pennwalt 

14-Sep1981 

112
Corp., Philadelphia, Pa.; CDL:246012-P) 

84615 Pennwalt Corporation (1981) Efficacy of Endothal on Turf. (Compilation; unpublished 

study received Sep 14, 1981 under 4581- 349; CDL:246013-A) 

14-Sep1981 

Landolt, M.L.; Felton, S.P.; Liguori, V.M.; et al. (1981) Toxicity of Endothall to Juvenile 

Chinook Salmon (Oncorhynchus tshawytscha). Final report (Washington, Dept. of Fisheries 

84991 for U.S. Army Corps of Engineers, Waterways Experiment Station, Aquatic Plant Control 

Research Program; unpublished study, including published data and letters dated Aug 5, 

21-Oct1981 

1981 from B.D. Gaughey to Gary Wedemeyer and Aug 27, 1981 from G.A. Wedemeyer to 

Bernalyn D. McGaughey; CDL:246080-A) 

Rosebery, G.D. (1981) Letter sent to Richard F. Mountfort dated Jul 20, 1981 Aquathol K 

86619 herbicide-Mutagenic and carcinogenic studies. Summary of studies 245680-B through 

245680-D. (Unpublished study received Jul 29, 1981 under 4581-204; submitted by 

29-Jul1981 

Pennwalt Corp., Philadelphia, Pa.; CDL:245680-A) 

Vigfusson, N.V. (1981) Evaluation of the Mutagenic Potential of Aquathol by the Induction 

86620 of Sister Chromatid Exchanges in Human Lymphocytes in Vitro. Final report. (Unpublished 

study received Jul 29, 1981 under 4581-204; prepared by Eastern Washington Univ., Dept. 

29-Jul1981 

of Biology, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:245680-B) 

Rundell, J.C.; Matthews, E.J. (1981) Evaluation of Aquathol K in the in Vitro 

86621 

Transformation of BALB/3T3 Cells with and without Metabolic Activation Assay: LBI 

Project No. 20992. Final report. (Unpublished study, including letter dated May 8, 1981 

from J.W. Tapp to Neil Peterson, received Jul 24, 1981 under 4581-204; prepared by Litton 

24-Jul1981 

Bionetics, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:245680-C) 

Folmar, L.C. (1976) Letter sent to Edward J. Bowles dated Jun 9, 1976 Results from 

95812 toxicity tests conducted on rainbow trout fertilized eggs and sac fry with Aquathol K. (U.S. 

Fish and Wildlife Service, Bureau of Recla mation, Denver Fish-Pesticide Research Unit; 

05-Jan1978 

unpublished study; CDL:096705-J) 

96295 

Walker, C.R. (1963) Letter sent to Harold L. Lindaberry dated Nov 8, 1963 Fish toxicity 

studies. (U.S. Fish and Wildlife Service, Fish Control Laboratory; unpublished study; 

CDL:090719-G) 

23-Mar1967 

Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study 

97831 No. 6915A. (Unpublished study received Sep 14, 1981 under 4581-349; prepared by Food 

and Drug Research Lab- oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

14-Sep1981 

CDL:246012-L) 

Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study 

97832 No. 6915A. (Unpublished study received Sep 14, 1981 under 4581-349; prepared by Food 

and Drug Research Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

14-Sep1981 

CDL:246012-M) 

Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study 

97833 No. 6915A. (Unpublished study received Sep 14, 1981 under 4581-349; prepared by Food 

and Drug Research Lab- oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

14-Sep1981 

CDL:246012-N) 

99204 

Applied Biochemists, Incorporated (1973) Toxicity Data for Copper- triethanolamine 

Complex on Ring-necked Pheasant and Mallard Duck. (Unpublished study received Nov 

21, 1973 under 8959-12; CDL:010116-B) 

21-Nov1973 

99448 

Schmidt, J. (1974) Subacute Toxicities of Cutrine and Weedtrine- Plus to Ring-necked 

Pheasants (Phasianus colchicus) & Mallard Ducks (Anus platyrhynchos): Dietary LC50. 

(Unpublished study received Jun 14, 1976 under 8959-11; submitted by Applied Bio14-Jun1976 

113
chemists, Inc., Mequon, WI; CDL:224874-B) 

Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study 

104758 No. 6915A. (Unpublished study received Sep 14, 1981 under 4581-349; prepared by Food 

and Drug Research Lab- oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

14-Sep1981 

CDL:246012-K) 

Pennwalt Corp. (1982) Report to Pennwalt Corporation: Two-year Chronic Oral Toxicity 

109473 and Carcinogenic Study with Dipotassium Endothal Monohydrate or Disodium Endothal in 

Albino Rats. (Compilation; unpublished study received Aug 12, 1982 under 1F1105; 

12-Aug1982 

CDL:071035-A; 071036; 071037; 071038; 071039; 071040; 071041 071042; 071043) 

113695 

Davis, J.; Hughes, J. (1963) Further Observations on the Toxicity of Commercial 

Herbicides to Bluegill Sunfish. (Louisiana, Wild Life and Fisheries Commission; 

unpublished study; CDL: 098334-F) 

13-Jun1979 

113932 

Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, Including 

a Description of the Analytical Methods Used: Endothall. (Compilation; unpublished study 

received Jul 9, 1975 under 1F1105; CDL:094703-A; 094704) 

09-Jul1975 

113935 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 

(Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094508-A) 

01-Dec1970 

113936 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 

(Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094507-A) 

01-Dec1970 

113938 

Pennwalt Corp. (1972) Toxicity Study: Endothall on Rats & Fish. Summary of studies 

094506-C and 094506-D. (Unpublished study received May 31, 1972 under 1F1105; 

CDL:094506-B) 

31-May1972 

113939 

Van Duuren, B. (1972) Gastric Feeding in Rats: Beta-Propiolactone and Endothall. 

(Unpublished study received May 31, 1972 under 1F1105; prepared by New York Medical 

Center, submitted by Pennwalt Corp., Tacoma, WA; CDL:094506-C) 

04-May1972 

31-May1972 

28-Apr113953 

Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining, 

Including a Description of the Analytical Method Used: Endothall. (Compilation; 

unpublished study received May 13, 1972 under 1F1105; CDL:094506-H) 

1972 

04-May1972 

13-May1972 

113959 

Watson, J. (1971) Full Reports of Investigations Made with Respect to the Safety of the 

Product: Endothall. (Unpublished study received Aug 11, 1971 under 1F1057; submitted by 

Pennwalt Corp., Tacoma, WA; CDL:091892-A) 

11-Aug1971 

113971 

Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of 

the Product: Endothall. (Compilation; unpublished study received on unknown date under 

1F1105; CDL:094509-A) 

03-May1971 

113987 

Agchem (1970) The Results of Tests on the Amount of Residue Remain- ing Including a 

Description of the Analytical Method Used: Endothall. (Compilation; unpublished study 

received Jun 27, 1971 under unknown admin. no.; CDL:124882-A) 

27-Jun1971 

114487 

Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and 

Complete Composition of the Product: Endothall. (Compilation; unpublished study received 

Jul 9, 1975 under 1F1105; CDL:094700-A) 

09-Jul1975 

114488 Pennwalt Corp. (1975) Full Reports and Data of Investigations Made on the Safety of the 

Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study 

09-Jul1975 

114
received Jul 9, 1975 under 1F1105; CDL:094702-A) 

114494 

Folmar, L. (19) Letter sent to E. Bowles circa Dec 13, 1974 Aquathol K. (U.S. Dept. of the 

Interior, Bureau of Reclamation, Engineering and Research Center, Denver Fish Pesticide 

Unit; unpublished study; CDL:094702-K) 

09-Jul1975 

McCollum, K. (1973) Report to Pennwalt Corporation: 21-day Sub- acute Oral Toxicity 

114497 Study with Dipotassium Endothall and Disodium Endothall in Albino Rats: IBT No. 621­

03463. (Unpublished study received Jul 9, 1975 under 1F1105; prepared by Industrial Bio09-Jul1975 

Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:094702-N) 

Morrow, L. (1975) Report to ...: Two-year Chronic Oral Toxicity and Carcinogenic Study 

114498 with Dipotassium Endothall Monohydrate or Disodium Endothall in Albino Rats: IBT No. 

621-03115. (Unpublished study received Jul 9, 1975 under 1F1105; prepared by Industrial 

09-Jul1975 

Bio-Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:094702-O) 

114499 Pennwalt Corp. (1962) Chemical and Physical Properties: Endothall. (Compilation; 

unpublished study received Jul 9, 1975 under 1F1105; CDL:094706-A) 

09-Jul1975 

114500 Pennwalt Corp. (1975) Toxicity: Endothall. (Compilation; unpublished study received Jul 9, 

1975 under 1F1105; CDL:094706-B) 

09-Jul1975 

114501 Pennwalt Corp. (1974) Residues: Endothall. (Unpublished study received Jul 9, 1975 under 

1F1105; CDL:094706-C) 

09-Jul1975 

114504 Pennwalt Corp. (1975) Duration of Biological Activity: Endothall. (Unpublished study 

received Jul 9, 1975 under 1F1105; CDL: 094706-F) 

09-Jul1975 

114505 Agchem (1954) Toxicological Investigations--Mammals: Endothall. (Unpublished study 

received Mar 15, 1966 under 4581-139; CDL: 007441-A) 

15-Mar1966 

114511 

Cope, O. (1965) Letter sent to E. Bowles dated Jul 23, 1965 Toxicity study of several 

Pennsalt herbicides against rainbow trout. (U.S. Fish and Wildlife Service, Fish-Pesticide 

Research Laboratory; unpublished study; CDL:007441-K) 

15-Mar1966 

114513 

U.S. Fish and Wildlife Service, Fish Control Laboratory (19) Toxicity Study of Selected 

Test Chemicals on Rainbow Trout, Goldfish, Black Bullhead, and Bluegill. (Unpublished 

study; CDL:007441 -M) 

15-Mar1966 

114525 Agchem (1963) Study: Endothall Breakdown in the Environment. (Compilation; 

unpublished study received Mar 15, 1966 under 4581-139; CDL:007441-AD) 

15-Mar1966 

Keckemet, O. (1963) Letter sent to Ag. Chem. File dated Feb 11, 1963: Microbiological 

114526 breakdown of endothal weed killer & derivatives. (Unpublished study received Mar 15, 

1966 under 4581 - 139; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; 

15-Mar1966 

CDL:007441-AE) 

114531 

Agchem (1972) Toxicity of Endothall in Animals. Summary of studies 095336-H, 094506­

C and 094506-D. (Unpublished study received May 4, 1972 under 4581-284; CDL:095336-

C) 

04-May1972 

114540 

Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the 

Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15, 

1970 under 0F0972; submitted by Pennwalt Corp., Tacoma, WA; CDL:095421-F) 

15-Apr1970 

114556 

Carlson, R.; Sandeno, J. (1970) Effect of Endothall on the Growth of Several Fungi. 

(Unpublished study received Oct 26, 1978 under 4581-282; submitted by Agchem Div., 

Pennwalt Corp., Philadelphia, PA; CDL:235432-B) 

26-Oct1978 

116025 Pennwalt (1970) Endothal: Residues in Various Crops. (Compilation; unpublished study 

received on unknown date under 1F1105; CDL:090872-A) 

115
Watson, J. (1972) Full Reports of Investigations Made with Respect to the Safety of the 

116026 Pesticide Chemical: Endothall. Summary of studies 090872-C through 090872-G. 

(Unpublished study received on unknown date under 1F1105; submitted by Pennwalt, 

Tacoma, WA; CDL:090872-B) 

116027 

Duuren, B. (19) Gastric Feeding in Rats: beta-Propiolactone and Endothall. (Unpublished 

study received Dec 27, 1961 under 1F1105; prepared by New York Medical Center, 

submitted by Pennwalt, Takoma, WA; CDL:090872-C) 

27-Dec1961 

Mixon, W. (1971) Endothall Residue in Goldfish--Feeding Study. (Unpublished study 

116028 received on unknown date under 1F1105; submitted by Pennwalt, Takoma, WA; 

CDL:090872-D) 

116457 Agchem (1962) Efficacy of Dipotassium Endothal. (Compilation; unpublished study 

received Jan 29, 1963 under 4581-200; CDL: 110609-A) 

29-Jan1963 

116458 Rock, L. (1963) Letter sent to unknown recipient dated Jan 8, 1963 Potassium Endothal: 

Toxicity to fish. (Illinois, Dept. of Conservation; unpublished study; CDL:110609-B) 

29-Jan1963 

116471 

McCann, J. (1969) Aquathol Plus Granular: Bluegill (Lepomis macrochirus). (U.S. 

Agricultural Research Service, Pesticides Regulation Div., Animal Biology Laboratory; 

unpublished study; CDL:132041-A) 

18-Apr1969 

124622 

Agchem (1970) Some Additional Information Pertaining to Fate of Endothall in the 

Environment: Summary. (Unpublished study received Dec 1, 1970 under 1F1105; 

CDL:094511-A) 

01-Dec1970 

Rodgers, J.; Reinert, K.; Hinman, M.; et al. (1983) Water Quality Monitoring in 

137746 

Conjunction with the Pat Mayse Lake Aquatic Plant Program. (Unpublished study received 

Mar 23, 1984 under 4581- 201; prepared by North Texas State Univ., Institute of Applied 

Sciences and Dept. of Biological Sciences, submitted by Agchem Div., Pennwalt Corp., 

23-Mar1984 

Philadelphia, PA; CDL:252749-A) 

138445 

Mixon, W. (1971) Endothall Residue in Goldfish--Feeding study. (Unpublished study 

received May 31, 1972 under 1F1105; submitted by Pennwalt Corp., Tacoma, WA; 

CDL:094506-D) 

04-May1972 

31-May1972 

138446 

Serns, S. (1974) The Effects of a Dipotassium Endothall Treatment on the Ecology of a 

Small Pond. (Wisconsin, Dept. of Natural Resources, Water Resources Research Section; 

unpublished study; CDL:094702-J) 

09-Jul1975 

Folmar, L. (1976) Overt avoidance reaction of rainbow trout fry to nine herbicides. Bulletin 

138964 of Environmental Contamination & Toxicology 15(5):509-514. (Also In unpublished 

submission received Feb 6, 1984 under 239-2424; submitted by Chevron Chemical Co., 

06-Feb1984 

Richmond, CA; CDL:252355 -D) 

Folmar, L. (1978) Avoidance chamber responses of mayfly nymphs exposed to eight 

138965 herbicides. Bulletin of Environmental Contamination & Toxicology 17:312-318. (Also In 

unpublished submission received Feb 6, 1984 under 239-2424; submitted by Chevron 

06-Feb1984 

Chemical Co., Richmond, CA; CDL:252355 -E) 

41037600 Pennwalt Corp. (19) Submission of Data To Support Registration of Endothall: Toxicology 

Data. Transmittal of 1 study. 

Strange, J. (1983) IBT Validation Report-Endothall Two-year Chronic Oral Toxicity and 

41037601 Carcinogenic Study with Dipotassium Endothall Monohydrate or Disodium Endothall in 

Albino Rats: IBT No. 621-03115. Unpublished study prepared by Dynamac Corp. 8 p. 

42289100 Atochem North America (1992) Submission of Data To Support Reregistration of 20-Apr116
Endothall, K-Salt: Toxicology Studies. Transmittal of 6 studies. 1992 

42289101 

Mallory, V. (1991) Acute Exposure Oral Toxicity in Rats with Pelletized Aquathol K: Lab 

Project Number: PH 402-ANA-008-91. Unpublished study prepared by Pharmakon 

Research International, Inc. 42 p. 

20-Apr1992 

42289102 

Mallory, V. (1991) Acute Exposure Dermal Toxicity with Pelletized Aquathol K: Rabbits: 

Lab Project Number: PH 422-ANA-008-91. Unpublished study prepared by Pharmakon 

Research International, Inc. 32 p. 

20-Apr1992 

42289103 

Mallory, V. (1991) Primary Eye Irritation with Pelletized Aquathol K: Rabbits: Lab Project 

Number: PH 421-ANA-008-91. Unpublished study prepared by Pharmakon Research 

International, Inc. 33 p. 

20-Apr1992 

42289104 

Mallory, V. (1991) Primary Dermal Irritation Study with Pelletized Aquathol K: Ra bbits: 

Lab Project Number: PH 420-ANA-008-91. Unpublished study prepared by Pharmakon 

Research International, Inc. 27 p. 

20-Apr1992 

42289105 

Armondi, S. (1991) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with 

Pelletized Aquathol K: Lab Project Number: PH 424-ANA -007-91. Unpublished study 

prepared by Pharmakon Research International, Inc. 56 p. 

20-Apr1992 

42289106 

Wang, W. (1991) Hydrolysis of carbon 14-Endothall Dipotassium Salt in Water at pH 5, 7 

and 9: Final Report: Lab Project Number: XBL 91022: RPT0070. Unpublished study 

prepared by XenoBiotic Laboratories, Inc. 61 p. 

20-Apr1992 

42338900 Atochem North America (1992) Submission of toxicity data to support the reregistration 

standard for Endothall (dipotassium salt). Transmittal of 5 studies. 

01-Jun1992 

42338901 

Mallory, V. (1991) Acute Exposure Oral Toxicity in Rats with Aquathol K: Lab Project 

Number: PH 402-ANA-004-91. Unpublished study prepared by Pharmakon Research Intl. 

55 p. 

01-Jun1992 

42338902 

Mallory, V. (1991) Acute Exposure Dermal Toxicity with Aquathol K: Lab Project 

Number: PH 422-ANA-004-91. Unpublished study prepared by Pharmakon Research Intl. 

32 p. 

01-Jun1992 

42338903 Mallory, V. (1991) Primary Eye Irritation with Aquathol K: Lab Project Number: PH 421-

ANA-004-91. Unpublished study prepared by Pharmakon Research Intl., Inc. 32 p. 

01-Jun1992 

42338904 Mallory, V. (1991) Primary Dermal Irritation Study with Aquathol K: Lab Project Number: 

PH 420-ANA-004-91. Unpublished study prepared by Pharmakon Research Intl., Inc. 27 p. 

01-Jun1992 

42338905 

Armondi, S. (1991) A Comparative Delayed Contact Hypersensitivity Study in Guinea Pigs 

(Buehler) with Aquathol K: Lab Project Number: PH 424-ANA-003-91. Unpublished study 

prepared by Pharmakon Research Intl., Inc. 76 p. 

01-Jun1992 

42359500 Atochem North America (1992) Submission of Toxicity Data in Supprot of Reregistration 

for Dipotassium Salt of endothall. Transmittal of 1 study. 

17-Jun1992 

42359501 

Pedersen, C.; Helsten, B. (1992) Aquathol K Aquatic Herbicide: 21-Day Acute Oral LD50 

Study in Mallard Ducks: Lab Project Number: 106-006-04. Unpublished study prepared by 

Bio-Life Associates, Ltd. 54 p. 

17-Jun1992 

42396400 Elf Atochem North America, Inc. (1992) Submission of toxicity data in support of the 

reregistration of Dipotassium Salt of Endothall. Transmittal of 6 studies. 

13-Jul1992 

42396401 

Hoberg, J. (1992) Dipotassium Salt of Endothall--Toxicity to the Freshwater Bluegreen 

Alga Anabaena flosaquae: Final Report: Lab Project Number: 91-12-4035. Unpublished 

study prepared by Springborn Laboratories, Inc. 59 p. 

13-Jul1992 

117
42396402 

Hoberg, J. (1992) Dipotassium Salt of Endothall--Toxicity to the Freshwater Diatom 

Navicula pelliculosa: Final Report: Lab Project Number: 91-12-4049. Unpublished study 

prepared by Springborn Laboratories, Inc. 61 p. 

13-Jul1992 

42396403 

Hoberg, J. (1992) Dipotassium Salt of Endothall--Toxicity to the Freshwater Green Alga, 

Selenastrum capricornutum: Final Report: Lab Project Number: 91-12-4053. Unpublished 

study prepared by Springborn Laboratories, Inc. 61 p. 

13-Jul1992 

42396404 

Hoberg, J. (1992) Dipotassium Salt of Endothall--Toxicity to the Marine Diatom, 

Skeletonema costatum: Final Report: Lab Project Number: 92-1-4063. Unpublished study 

prepared by Springborn Laboratories, Inc. 60 p. 

13-Jul1992 

Hoberg, J. (1992) Dipotassium Salt of Endothall--Determination of Effects on Seed 

42396405 Germination, Seedling Emergence and Vegetative Vigor of Ten Plant Species: Final 

Report: Lab Project Number: 91-11-4015: 12442.0391.6117.610: BR-91-55. Unpublished 

13-Jul1992 

study prepared by Springborn Laboratories, Inc. 353 p. 

42396406 

Hoberg, J. (1992) Dipotassium Salt of Endothall--Toxicity to the Duckweed Lemna gibba: 

Final Report: Lab Project Number: 92-2-4097: 12442.0391.6118.410: BR-91-54. 

Unpublished study prepared by Springborn Laboratories, Inc. 45 p. 

13-Jul1992 

42407100 Atochem North America (1992) Submission of Toxicity Data in Support of the 

Reregistration of Aquathol K. Transmittal of 2 studies. 

20-Jul1992 

42407101 Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Aquathol K in the Rat: Lab 

Project Number: 91/8357. Unpublished study prepared by Bio/dynamics, Inc. 133 p. 

20-Jul1992 

42407102 

Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Pelletized Aquathol K in the 

Rat: Lab Project Number: 91-8345: Unpublished study prepared by Bio/dynamics, Inc. 124 20-Jul1992 

p. 

42427600 Atochem North America (1992) Submission of exposure data in support of the Phase 4 

requirements for Endothall. Transmittal of 1 study. 

05-Aug1992 

Baugher, D.; Meikle, S. (1992) Field Spray Drift Evaluation of Endothall (Accelerate 

42427601 Herbicide) Results of Wind Tunnel Testing of Aerial and Airblast Application Nozzles: Lab 

Project Number: 32389: BR-89-48: 55-END/92028. Unpublished study prepared by Orius 

05-Aug1992 

Associates, Inc. 152 p. 

42495500 Elf Atochem North America, Inc. (1992) Submission of toxicity data in support of the 

reregistration of Endothall, K-Salt. Transmittal of 1 study. 

02-Oct1992 

42495501 

Margitich, D.; Ackerman, L. (1992) 21 Day Dermal Toxicity Study in Rats: Aquathol K: 

Lab Project Number: PH 430-ANA-002-91. Unpublished study prepared by Pharmakon 

Research International, Inc. 330 p. 

02-Oct1992 

42618900 Atochem North America, Inc. (1993) Submission of environmental data in support of the 

data call-in for endothal acid. Transmittal of 1 study. 

08-Jan1993 

42618901 

Reynolds, J. (1992) Aerobic Aquatic Metabolism of (carbon 14)-Endothall Dipotassium 

Salt: Lab Project Number: XBL 91024: RPT0083: BR-91-46. Unpublished study prepared 

by XenoBiotic Labs, Inc. 81 p. 

08-Jan1993 

42629900 Elf Atochem N.A., Inc. (1993) Submission of product chemistry data in support of the data 

call-in for Endothall, K Salt. Transmittal of 1 study. 

21-Jan1993 

42629901 

Sweetapple, G. (1992) Dipotassium Endothall--Color, Physical State, Odor, Melting Point, 

Bulk Density, pH: Lab Project Number: 4200-92-0335-AS: 4200-92-0335-AS-001. 

Unpublished study prepared by Ricerca, Inc. 36 p. 

21-Jan1993 

42644000 Atochem North America, Inc. (1993) Submission of environmental fate data to support 28-Jan118
Endothall reregistration. Transmittal of 1 study. 1993 

42644001 

Dionne, E. (1992) Dipotassium Salt of Endothall: Bioconcentration and Elimination of 

(carbon 14)-residues with Bluegill Sunfish: Final Report: Lab Project Number: 92-5-4269: 

12442.0391.6115.140. Unpublished study prepared by Springborn Labs, Inc. 92 p. 

28-Jan1993 

42670100 Elf Atochem N.A., Inc. (1993) Submission of environmental fate data in support of the 

Endothall (K Salt) data call-in. Transmittal of 1 study. 

18-Feb1993 

42670101 

Wright, J. (1993) Terrestrial Field Dissipation Studies for Endothall (Herbicide 273 Sugar 

Beet Herbicide) Applied to Sugar Beets: Lab Project Number: WT-2-85: BR-92-53. 

Unpublished study prepared by Pennwalt Corp. 223 p. 

18-Feb1993 

42695400 Elf Atochem (1993) Submission of toxicity data in support of the data call-in for Endothall, 

K Salt. Transmittal of 6 studies. 

15-Mar1993 

Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall) --Acute Toxicity to 

42695401 Bluegill Sunfish (Lepomis macrochirus) under Flow-through Conditions: Final Report: Lab 

Project Number: 92-3-4192: 1244.0591.6133.105. Unpublished study prepared by 

15-Mar1993 

Springborn Labs, Inc. 62 p. 

Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall)--Acute Toxicity to 

42695402 Rainbow Trout (Oncorhynchus mykiss) under Flow-through Conditions: Final Report: Lab 

Project Number: 92-3-4163: 12442.0591.6132.108. Unpublished study prepared by 

15-Mar1993 

Springborn Labs, Inc. 63 p. 

42695403 

Putt, A. (1993) Aquathol K (Dipotassium Salt of Endothall)--Acute Toxicity to Daphnids 

(Daphnia magna) under Flow-through Conditions: Final Report: Lab Project Number: 92-3-

4153: 12442.0591.6134.115. Unpublished study prepared by Springborn Labs, Inc. 69 p. 

15-Mar1993 

Dionne, E. (1993) Aquathol K (Dipotassium Salt of Endothall)--Acute Toxicity to Eastern 

42695404 Oyster (Crassostrea virginica) under Flow-through Conditions: Final Report: Lab Project 

Number: 92-3-4149: 12442.0591.6137.504. Unpublished study prepared by Springborn 

15-Mar1993 

Labs, Inc. 66 p. 

Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall)--Acute Toxicity to 

42695405 Sheepshead Minnow (Cyprinodon variegatus) under Flow-through Conditions: Final 

Report: Lab Project Number: 92-2-4110: 12442.0591.6135.505. Unpublished study 

15-Mar1993 

prepared by Springborn Labs, Inc. 64 p. 

Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall)--Acute Toxicity to 

42695406 Mysid Shrimp (Mysidopsis bahia) under Flow-through Conditions: Final Report: Lab 

Project Number: 92-9-4411: 12442.0591.6136.515. Unpublished study prepared by 

15-Mar1993 

Springborn Labs, Inc. 66 p. 

42787700 Elf Atochem North America, Inc. (1993) Submission of product chemistry data in support 

of the reregistration for Endothall, K Salt. Transmittal of 2 studies. 

26-May1993 

42787701 

Wojcieck, B. (1993) Aquathol Granular--Color, Physical State, Odor, Bulk Density, pH: 

Lab Project Number: 4200-92-0178-AS: 4200-92-0178-AS-001. Unpublished study 

prepared by Ricerca, Inc. 37 p. 

26-May1993 

42787702 

Gallacher, A. (1993) Dipotassium Endothall--Dissociation Constant: Lab Project Number: 

4200-92-0324-AS: 4200-92-0324-AS-001. Unpublished study prepared by Ricerca, Inc. 54 26-May1993 

p. 

42792700 Elf Atochem North America, Inc. (1993) Submission of metabolism data in response to DCI 

for Endothall Acid (Technical). Transmittal of 2 studies 

01-Jun1993 

42792702 Reynolds, J. (1993) Aerobic Soil Metabolism of (carbon 14) -Endothall Dipotassium Salt: 01-Jun119
Lab Project Number: XBL 91023: RPT00115: BR-91-44. Unpublished study prepared by 1993 

XenoBiotic Labs., Inc. 91 p. 

42814100 Elf Atochem North America, Inc. (1993) Submission of additional range finding toxicity 

data in support of reregistration for Endothall K Salt. Transmittal of 1 study. 

18-Jun1993 

42814101 

Margitich, D.; Ackerman, L. (1992) Aquathol K: 21 Day Dermal Toxicity Study in Rats: 

Lab Project Number: PH 430-ANA-001-91. Unpublished study prepared by Pharmakon 

Research International, Inc. 275 p. 

18-Jun1993 

42882500 Elf Atochem North America, Inc. (1993) Submission of Product Chemistry Data in Support 

of Reregistration of Endothall K Salt. Transmittal of 1 Study. 

16-Aug1993 

42882501 

Wojcieck, B. (1993) Aquathol K: Color, Physical State, Odor, Specific Gravity, pH, 

Viscosity: Lab Project Number: 4200-92-0176-AS: 4200 -92-0176-AS-001. Unpublished 

study prepared by Ricerca, Inc. 46 p. 

16-Aug1993 

42903900 Elf Atochem North America, Inc. (1993) Submission of Metabolism Data for (Carbon 14)-

Endothall Dipotassium Salt in Support of Reregistration. Transmittal of 1 Study. 

31-Aug1993 

42903901 

Reynolds, J. (1993) Anaerobic Aquatic Metabolism of (Carbon 14C)-Endothall 

Dipotassium Salt: Lab Project Number: XBL 91025: RPT00116: BR-91-45. Unpublished 

study prepared by XenoBiotic Lab., Inc. 106 p. 

31-Aug1993 

43081800 Elf Atochem North America, Inc. (1993) Submission of product chemistry data in response 

to DCI for reregistration of endothall dipotassium salt. Transmittal of 2 studies. 

11-Jan1994 

43081801 Sweetapple, G. (1993) Aquathol K--Corrosion Characteristics: Lab Project Number: 

4200/92/0177/AS/001. Unpublished study prepared by Ricerca, Inc. 35 p. 

11-Jan1994 

43081802 Sweetapple, G. (1993) Aquathol Granular--Corrosion Characteristics: Lab Project Number: 

4200/92/0179/AS/001. Unpublished study prepared by Ricerca, Inc. 35 p. 

11-Jan1994 

43167800 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Aquathol K 

Aquatic Herbicide in Support of Reregistration Data Call-in. Transmittal of 2 studies. 

22-Mar1994 

43167801 

Pedersen, C. (1994) Aquathol K Aquatic Herbicide: 8-Day Acute Dietary LC50 Study in 

Bobwhite Quail: Lab Project Number: 106-013-01: HWA 153-150. Unpublished study 

prepared by Bio-Life Associates, Ltd. 102 p. 

22-Mar1994 

43167802 

Pedersen, C. (1994) Aquathol K Aquatic Herbicide: 8-Day Acute Dietary LC50 Study in 

Mallard Ducklings: Lab Project Number: 106-017-02: HWA 153-150. Unpublished study 

prepared by Bio-Life Associates, Ltd. 97 p. 

22-Mar1994 

43264900 Elf Atochem North America, Inc. (1994) Submission of product chemistry (stability) data in 

support of reregistration of Endothall, K-salt. Transmittal of 1 study. 

10-Jun1994 

43264901 Malone, S. (1994) Dipotassium Endothall TG (B46 -50): Stability: Lab Project Number: 

4200/92/0327/AS/001. Unpublished study prepared by Ricerca, Inc. 57 p. 

10-Jun1994 

43299900 Elf Atochem North America, Inc. (1994) Submission of exposure assessment data in 

support of DCI for reregistration of endothall. Transmittal of 1 study. 

12-Jul1994 

43299901 

Lunchick, C. (1994) Assessment of Worker Exposure and Margins of Exposure for 

Endothall Potassium and Amine Salt Formulation: Lab Project Number: EA070594. 

Unpublished study prepared by Jellinek, Schwartz & Connolly, Inc. 82 p. 

12-Jul1994 

43315800 Elf Atochem North America, Inc. (1994) Submittal of Environmental Fate Data in Support 

of Registration Standard for Endothall. Transmittal of 1 study. 

26-Jul1994 

43315801 Dionne, E. (1994) Metabolism of Endothall Dipotassium Salt in Bluegill Sunfish (Lepomis 26-Jul120
macrochirus): Identification and Characterization of Metabolites in Fillet and Viscera: Lab 1994 

Project Number: 12442.0391.6115.180: BR-91-53: 94-2-5168. Unpublished study prepared 

by Springborn Labs, Inc. and XenoBiotic labs Inc. 155 p. 

43470100 Elf Atochem North America, Inc. (1994) Submission of Exposure Data in Support of 

Endothall Reregistration. Transmittal of 1 Study. 

02-Dec1994 

43470101 

Lunchick, C. (1994) Assessment of Swimmer Exposure to Endothall in Aquathol- and 

Hydrothol- Treated Bodies of Water. Unpublished study prepared by Jellinek, Schwartz, 

and Connolly, Inc. 11 p. 

02-Dec1994 

43472800 Elf Atochem North America, Inc. (1994) Submission of Toxicity and Product Chemistry 

Data in Support of the Reregistration of Endothall, Amine Salt. Transmittal of 3 Studies. 

06-Dec1994 

43472803 

Lorence, P. (1994) Dipotassium Endothall--Octanol/Water Partition Coefficient: Lab 

Project Numbers: 4200-92-0256-AS: 4200-92-0256-AS-001. Unpublished study prepared 

by Ricerca, Inc. 51 p. 

06-Dec1994 

43551700 Elf Atochem North America, Inc. (1995) Submission of Product Chemistry Data in Support 

of the Reregistration of Dipotassium Salt of Endothall. Transmittal of 1 Study. 

25-Jan1995 

43551701 

Lorence, P. (1994) Dipotassium Endothall--Solubility: Lab Project Numbers: 4200-92-

0257-AS: 4200-92-0257-AS-001: 4200-92-0257-AS-000. Unpublished study prepared by 

Ricerca, Inc. 67 p. 

25-Jan1995 

43873900 

Elf Atochem North America, Inc. (1995) Submis sion of Product Chemistry Data in Support 

of the Amended Registrations of Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic 

Algicide and Herbicide. Transmittal of 2 Studies. 

13-Dec1995 

43873901 

Lincks, G. (1994) Aquathol K Aquatic Herbicide Manufacturing Process: Lab Project 

Number: QC0006R0.QTR. Unpublished study prepared by Elf Atochem North America, 

Inc. 27 p. 

13-Dec1995 

43965300 

Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in Support 

of the Amended Registration of HERBICIDE 273 Sugar Beet Herbicide. Transmittal of 1 

Study. 

29-Mar1996 

43965301 

Lincks, G. (1994) Herbicide 273 Sugar Beet Herbicide Manufacturing Process: Lab Project 

Number: QC0008R0.QTR. Unpublished study prepared by Elf Atochem North America, 

Inc. 27 p. 

29-Mar1996 

43966000 

Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in Support 

of the Amended Registration of Aquathol Granular Aquatic Herbicide. Transmittal of 1 

Study. 

14-Mar1996 

43966001 

Lincks, G.; Parker, J.; Wright, J. (1994) Aquathol Granular Aquatic Herbicide 

Manufacturing Process: Lab Project Number: QC0011R0.QTR. Unpublished study 

prepared by Elf Atochem North America, Inc. 23 p. 

14-Mar1996 

44037400 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the 

Reregistration of Endothall and Salts. Transmittal of 2 Studies. 

18-Jun1996 

44037401 

Ussary, J. (1996) Endothall: Magnitude of the Residue in Sugar Beet Processing Fractions: 

Final Report: Lab Project Number: BR-90-10: 53-90: 53A-90. Unpublished study prepared 

by Elf Atochem North America, Inc.; McKenzie Labs; and Oaks Experimental Farm. 178 p. 

18-Jun1996 

44093400 Elf Atochem North America, Inc. (1996) Submission of Residue and Environmental Fate 

Data in Support of the Reregistration of Endothall and its Salts. Transmittal of 3 Studies. 

26-Aug1996 

44093402 Ritter, A.; Williams, W. (1996) Aquathol-K: The Rate of Dissipation of Endothall as a 

Result of Degradation versus Dilution: Lab Project Number: WEI 286.03: ATO BR-94-17: 

26-Aug1996 

121
BR-94-17. Unpublished study prepared by Waterborne Environmental, Inc.; Springborn 

Labs., Inc.; and McKenzie Labs. 225 p. 

44093403 

Biever, R. (1996) Aquathol K: An Aquatic Dissipation Study for Aquatic Non-Crop Uses: 

Lab Project Number: 95-06-5898: 12442-0894-6181-330: BR-94-13. Unpublished study 

prepared by Springborn Labs., Inc. and McKenzie Labs., Inc. 375 p. 

26-Aug1996 

44263500 Elf Atochem North America, Inc. (1997) Submission of Metabolism and Residue Data in 

Support of the Reregistration of Endothall and Salts. Transmittal of 8 Studies. 

29-Apr1997 

44263502 

Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Orange RAC: (Final 

Report): Lab Project Number: BR-90-58: BR-90-58-1. Unpublished study prepared by 

McKenzie Labs, Inc. 109 p. 

29-Apr1997 

44263503 

Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Tomato RAC: Lab 

Project Number: BR-90-59: BR-90-59-1. Unpublished study prepared by McKenzie Labs, 

Inc. 105 p. 

29-Apr1997 

44263504 

Carr, B.; Amo s, L. (1997) Frozen Storage Stability of Endothall Residues in Broccoli RAC: 

(Final Report): Lab Project Number: BR-90-50: BR-90-50-1. Unpublished study prepared 

by McKenzie Labs, Inc. 125 p. 

29-Apr1997 

44263505 

Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Rice RAC: (Final 

Report): Lab Project Number: BR-90-51: BR-90-51-1. Unpublished study prepared by 

McKenzie Labs, Inc. 129 p. 

29-Apr1997 

Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44263506 Treatment of Celery with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR-91-02: 70-91: 

29-Apr1997 

70A-91. Unpublished study prepared by McKenzie Labs, Inc. 237 p. 

Toth, J.; Antle, P. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44263507 Treatment of Grapefruit with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: (Final Report): Lab Project Number: BR-91-04: 74-91: 74A-91. 

29-Apr1997 

Unpublished study prepared by McKenzie Labs, Inc. 224 p. 

Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44263508 Treatment of Peppers with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR-91-05: 73-91: 

29-Apr1997 

73A-91. Unpublished study prepared by McKenzie Labs, Inc. 223 p. 

44274400 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of the 

Reregistration for Endothall Acid & Salts. Transmittal of 1 Study. 

29-Apr1997 

44274401 

Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Spinach RAC: Lab 

Project Number: BR-90-52: BR-90-52-1. Unpublished study prepared by McKenzie 

Laboratories, Inc. 112 p. 

29-Apr1997 

44319600 

Elf Atochem North America, Inc. (1997) Submission of Product Chemistry and Toxicity 

Data in Support of the Application for Registration for Thin-Rite Blossom Thinner. 

Transmittal of 10 Studies. 

03-Jul1997 

44319601 

Parke r, J. (1997) Thin-Rite Apple Blossom Thinner: Product Chemistry: (Product Identity 

and Composition): Lab Project Number: QC0018RO.QTR. Unpublished study prepared by 

Elf Atochem North America, Inc. 30 p. {OPPTS 830.1600, 830.1620, 830.1670} 

03-Jul1997 

44319602 

Parker, J. (1997) Thin-Rite Apple Blossom Thinner: Product Chemistry: (Physical and 

Chemical Characteristics). Unpublished study prepared by Elf Atochem North America, 

Inc. 5 p. 

03-Jul1997 

122
Wright, J. (1997) ThinRite--Color, Physical State, Odor, Density, and pH: (Draft Final 

44319603 Report): Lab Project Number: QC9707A0.QTR: KP-97-07. Unpublished study prepared by 

Elf Atochem North America, Inc. 32 p. {OPPTS 830.6302, 830.6303, 830.6304, 830.7300, 

03-Jul1997 

830.7000} 

44319604 

Wright, J. (1997) ThinRite--Determination of Viscosity: (Draft Final Report): Lab Project 

Number: QC9712A0. QTR: KP-97-12. Unpublished study prepared by Elf Atochem North 

America, Inc. 21 p. {OPPTS 830.7100} 

03-Jul1997 

44319605 Wnorowski, G. (1997) Acute Oral Toxicity Defined LD50 (in Rats): ThinRite: Lab Project 

Number: 5071: P320. Unpublished study prepared by Product Safety Labs. 25 p. 

03-Jul1997 

44319606 Wnorowski, G. (1997) Acute Dermal Toxicity Limit Test (in Rabbits): ThinRite: Lab 

Project Number: 5072: P322. Unpublished study prepared by Product Safety Labs. 16 p. 

03-Jul1997 

44319607 Wnorowski, G. (1997) Acute Inhalation Toxicity Limit Test (in Rats): ThinRite: Lab 

Project Number: 5076: P330. Unpublished study prepared by Product Safety Labs. 24 p. 

03-Jul1997 

44319608 Wnorowski, G. (1997) Primary Eye Irritation (in Rabbits): ThinRite: Lab Project Number: 

5073: P324. Unpublished study prepared by Product Safety Labs. 22 p. 

03-Jul1997 

44319609 Wnorowski, G. (1997) Primary Skin Irritation (in Rabbits): ThinRite: Lab Project Number: 

5074: P326. Unpublished study prepared by Product Safety Labs. 17 p. 

03-Jul1997 

44319610 

Wnorowski, G. (1997) Dermal Sensitization Test--Buehler Method (in Guinea Pigs): 

ThinRite: Lab Project Number: 5075: P328. Unpublished study prepared by Product Safety 

Labs. 24 p. 

03-Jul1997 

44320100 

Elf Atochem North America, Inc. (1997) Submission of Product Chemistry and Toxicity 

Data in Support of the Application for Registration of Aquathol Super K Granular Aquatic 

Herbicide. Transmittal of 8 Studies. 

03-Jul1997 

44320101 

Parker, J. (1997) Aquathol Super K Granular Aquatic Herbicide: Product Chemistry: Lab 

Project Number: QC0017R0.QTR. Unpublished study prepared by Elf Atochem North 

America. 25 p. {OPPTS 830.1620, 830.1670}. 

03-Jul1997 

44320102 

Parker, J. (1997) Aquathol Super K Granular Aquatic Herbicide: Product Chemistry 

(Physical Chemical Characteristics). Unpublished study prepared by Elf Atochem North 

America. 5 p. 

03-Jul1997 

44320103 

Gibson, K. (1997) Aquathol Super K--Color, Physical State, Odor, Bulk Density, pH: Lab 

Project Number: QC9617A0.QTR: KP-96-17. Unpublished study prepared by Elf Atochem 

North America, Inc. 28 p. {OPPTS 830.6302, 830.6303, 830.6304, 830.7300, 830.7000}. 

03-Jul1997 

44320104 

Wnorowski, G. (1996) Acute Oral Toxicity Defined LD50 (in Rats): Aquathol Super K 

Granule: Lab Project Number: 4878: P320. Unpublished study prepared by Product Safety 

Labs. 26 p. 

03-Jul1997 

44320105 

Wnorowski, G. (1996) Acute Dermal Toxicity Limit Test (in Rabbits): Aquathol Super K 

Granule: Lab Project Number: 4879: P322. Unpublished study prepared by Product Safety 

Labs. 15 p. 

03-Jul1997 

44320106 Wnorowski, G. (1996) Primary Eye Irritation (in Rabbits): Aquathol Super K Granule: Lab 

Project Number: 4880: P324. Unpublished study prepared by Product Safety Labs. 23 p. 

03-Jul1997 

44320107 Wnorowski, G. (1996) Primary Skin Irritation (in Rabbits): Aquathol Super K Granule: Lab 

Project Number: 4881: P326. Unpublished study prepared by Product Safety Labs. 16 p. 

03-Jul1997 

44320108 

Wnorowski, G. (1996) Dermal Sensitization Test (in Guinea Pigs)--Buehler Method: 

Aquathol Super K Granule: Lab Project Number: 4882: P328. Unpublished study prepared 

by Product Safety Labs. 24 p. 

03-Jul1997 

123
44320400 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of Petition 

for Tolerance for Endothall on Apples. Transmittal of 3 Studies. 

03-Jul1997 

Ussary, J. (1997) Endothall: Magnitude of the Residue in Apples Treated with TD-2337, A 

44320401 New Blossom Thinner Use: Final Report: Lab Project Number: BR-95-05: 05-95: 05A-95. 

Unpublished study prepared by Ussary Scientific Services, Inc.; ABC labs, Inc.; and Elf 

03-Jul1997 

Atochem N.A., Inc. 213 p. 

Leppert, B.; Sharp, J. (1997) Magnitude of Residues of Endothall as TD-2337-03 Blossom 

44320402 Thinner in Apple Processed Fractions: (Final Report): Lab Project Number: KP-96-06: 

SARS-96-ID-80: SARS-96-WA-80A. Unpublished study prepared by Stewart Agricultural 

03-Jul1997 

Services, Inc. and Elf Atochem N.A., Inc. 164 p. 

44320403 Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number: 

FQPA 697E. Unpublished study prepared by Elf Atochem N.A., Inc. 42 p. 

03-Jul1997 

44334300 Elf Atochem N.A., Inc. (1997) Submission of Residue Data in Support of the Reregistration 

of Endothall Acid and Salts. Transmittal of 1 Study. 

25-Jul1997 

Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44334301 Treatment of Cabbage with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: Final Report: Lab Project Number: BR-91-01: 71A-91: 71B-91. 

25-Jul1997 

Unpublished study prepared by Elf Atochem N.A., Inc. and McKenzie Labs, Inc. 241 p. 

44343100 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of the 

Reregistration for Endothall Acid & Salts. Transmittal of 1 Study. 

06-Aug1997 

Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44343101 Treatment of Turnips with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: Lab Project Number: BR-91-06: 72A-91: 72B-91. Unpublished 

06-Aug1997 

study prepared by McKenzie Laboratories, Inc. 237 p. 

44392800 Elf Atochem N.A. Inc. (1997) Submission of Effects of Pesticides on Non-Target Plants 

Data in Support of the Reregistration for Endothall Acid & Salts. Transmittal of 3 Studies. 

01-Oct1997 

Hoberg, J. (1997) Dipotassium Salt of Endothall--Toxicity to the Freshwater Green Alga, 

44392801 Selenastrum capricornutum: Supplemental Information to Final Report (MRID #423964­

03): Lab Project Number: 91-12-4053A: 12442.0391.6118.430A: BR-91-58A. Unpublished 

01-Oct1997 

study prepared by Springborn Labs, Inc. 49 p. 

Hoberg, J. (1997) Dipotassium Salt of Endothall--Toxicity to the Freshwater Diatom, 

44392802 Novicula pelliculosa: Supplemental Information to Final Report (MIRD #426964-02): Lab 

Project Number: 91-12-4049A: 12442.0391.6118.440A: BR-91-57A. Unpublished study 

01-Oct1997 

prepared by Springborn Labs, Inc. 49 p. 

Hoberg, J. (1997) Dipotassium Salt of Endothall--Determination of the Effects on Seed 

44392803 

Germination, Seedling Emergence and Vegetative Vigor of Ten Plant Species: 

Supplemental Information to Final Report (MIRD #423964-05): Lab Project Number: 91­

114015A: 12442.0391.6117.610A: BR-91-55A. Unpublished study prepared by Springborn 

01-Oct1997 

Labs, Inc. 153 p. 

44408800 ELF Atochem North America, Inc. (1997) Submission of Toxicology Data in Support of the 

Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 

27-Oct1997 

Hoberg, J. (1997) Dipotassium Salt of Endothall--Toxicity to the Freshwater Blue-Green 

44408801 Alga, Anabaena flosaquae: Final Report: Lab Project Number: 91-12-4035A: 

12442.0391.6118.420A: BR-91-56A. Unpublished study prepared by Springborn Labs, Inc. 

27-Oct1997 

46 p. 

44557200 Elf Atochem North America, Inc. (1998) Submission of Product Chemistry Data in Support 04-May124
of the Application for Registration of Aquathol Super K Granular Aquatic Herbicide. 1998 

Transmittal of 1 Study. 

44557201 

Gitlitz, M. (1998) Particle Size and Friability of Granular Aquathol Super K Containing 

Fumed Silica as a Processing Aid: Lab Project Number: 10043. Unpublished study prepared 

by Elf Atochem North America Inc. 9 p. 

04-May1998 

44578400 Elf Atochem North America, Inc. (1998) Submission of Environmental Fate Data in 

Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 

11-Jun1998 

44578401 

Mao, J. (1997) Endothall Amine Salt--Determination of pH Dependent Hydrolysis: Lab 

Project Number: 12442.0396.6209.715: KP-96-01: 96-6-6537. Unpublished study prepared 

by Springborn laboratories, Inc. 79 p. 

11-Jun1998 

44608600 Elf Atochem North America, Inc. (1998) Submission of Residue Chemistry Data in Support 

of the Reregistration of Endothall Acids and Salts. Transmittal of 1 Study. 

16-Jul1998 

44608601 

Fomenko, J. (1998) Evaluation of Endothall Through the FDA Multiresidue Methods: Lab 

Project Number: A036.50: KP-97-18. Unpublished study prepared by Maxim Technologies, 

Inc. 63 p. {OPPTS 860.1360} 

16-Jul1998 

44820100 

Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, Risk 

Assessment and Exposure Data in Support of the Reregistration of Endothall Acid and 

Salts. Transmittal of 4 Studies. 

05-May1999 

Keckemet, O.; Sharp, J. (1999) Historical Aquatic Residue and Dissipation Data for 

44820101 Endothall Aquatic Products Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic 

Algicide and Herbicide: Lab Project Number: KP-99-02: WT-86-C-11. Unpublished study 

05-May1999 

prepared by Elf Atochem. 316 p. {OPPTS 860.1400} 

Dionne, E.; Sharp, J.; Formella, T. (1999) Dipotassium Salt of Endothall: A Freshwater Fish 

44820102 and Shellfish Magnitude of Residues Study in a Static Aquatic System: Lab Project 

Number: KP-97-14: 52897/171.4/FIFRA: EN1115.95. Unpublished study prepared by Elf 

05-May1999 

Atochem and ABC Laboratories, Inc. 213 p. {OPPTS 860.1400} 

44820103 

Biever, R. (1998) Hydrothol 191: An Aquatic Dissipation Study for Aquatic Non-Crop 

Uses: Final Report: Lab Project Number: KP-96-14: 98-1-7215: 12442-0896-6214-330. 

Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 164 p. 

05-May1999 

44820104 

Giddings, J. (1999) Ecological Risk Assessment of Aquatic Herbicides Containing 

Endothall: Final Report: Lab Project Number: KP-98-31: 98-11-7564: 12442-0898-6271-

251. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 64 p. 

05-May1999 

44828800 

Elf Atochem North America (1999) Submission of Environmental Fate Data in Support of 

the Reregistration of Endothall Acid and Salts Containing Products Aquathol K and 

Hydrothal 191. Transmittal of 2 Studies. 

05-May1999 

Singh, P.; Ritter, A.; Sharp, J. et al. (1999) Aquatic Dissipation Modeling of Endothall 

44828801 Acid: Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: 

Lab Project Number: ATO KP-97-16: WEI 286.01. Unpublished study prepared by 

05-May1999 

Waterborne Environmental, Inc. 363 p. 

Williams, W.; Ritter, A.; Sharp, J. et al. (1999) An Evaluation of the Aquatic Dissipation of 

44828802 Endothall Aquatic Product: Aquathol, K Aquatic Herbicide and Hydrothol 191 Aquatic 

Algicide and Herbicide: Lab Project Number: ATOKP-98-32: WEI-286.06. Unpublished 

05-May1999 

study prepared by Waterborne Environmental, Inc. 69 p. 

44976700 

Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the 

Reregistration of Endothall Acids and Salts Containing Product Hydrothol 191. Transmittal 

of 1 Study. 

20-Oct1999 

125
44976701 

Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191: A 96-Hour Toxicity Test with 

the Marine Diatom (Skeletonema costatum): Final Report: Lab Project Number: 299A-104. 

Unpublished study prepared by Wildlife International , Ltd. 38 p. {OPPTS 850.5400} 

20-Oct1999 

45031600 

Elf Atochem North America, Inc. (2000) Submission of Product Chemistry Data in Support 

of the Application for Registration of Aquathol Super K Granular Aquatic Herbicide. 

Transmittal of 1 Study. 

01-Feb2000 

45031601 

Wright, J. (1998) Determination of Storage Stability and Corrosion Properties of Aquathol 

Super K: Final Report: Lab Project Number: KP-96-18: QC9618R0.QTR. Unpublished 

study prepared by Elf Atochem N.A. 24 p. {OPPTS 830.6317, 830.6320} 

01-Feb2000 

45039500 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in Support 

of the Reregistration of Endothall and Endothall Salts. Transmittal of 1 Study. 

28-Jan2000 

45039501 

Toth, J. (1999) Immunochemical Method for Residues of Endothall in Water: Lab Project 

Number: KP-023-00. Unpublished study prepared by Elf Atochem North America, Inc. 74 

p. {OPPTS 850.7100} 

28-Jan2000 

45146300 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in Support 

of the Reregistration of Endothall Acid and its Salts. Transmittal of 2 Studies. 

19-Jun2000 

45146301 

Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potatoes: 

Final Report: Lab Project Number: KP-98-22: 22A-98: 22B-98. Unpublished s tudy 

prepared by Elf Atochem North America, Inc. 202 p. {OPPTS 860.1500} 

19-Jun2000 

Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potato 

45146302 Processing Fractions: Final Report: Lab Project Number: KP-98-23: 44884: 23A-98. 

Unpublished study prepared by Elf Atochem North America, Inc. 162 p. {OPPTS 

19-Jun2000 

860.1520} 

45764300 Cerexagri, Inc. (2002) Submission of Risk and Exposure Assessment Data in Support of the 

Registration of Endothall Aquatic Herbicides. Transmittal of 1 Study. 

25-Sep2002 

45764301 

Davis, C.; Ampofo, S. (2002) Exposure and Risk Assessment for Persons Reentering NonFood Areas Treated with Endothall Aquatic Herbicides via Irrigation Water. Unpublished 

study prepared by Cerexagri, Inc. 26 p. 

25-Sep2002 

92060000 Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Dipotassium 

endothall (7-oxabicyclo(2.2.1)heptane-2,3-dicar. 

26-May1990 

92060001 

Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

00084614. Primary Eye Irritation of Aquathol Granular: Aquatic Herbicide to Rabbits: 

Project No. 844057.: 12 p. 

26-May1990 

92060999 Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Dipotassium 

endothall (7-oxabicyclo(2.2.1)heptane-2,3-dicar. Correspondence and Supporting Material. 

26-May1990 

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California, Rice Experiment Station and Occidental Chemical Co., submitted by Pennwalt 

Corp., Agchem Div., King of Prussia, Pa.; CDL:096340-D) 

35236 Pennwalt Corporation (1975) Fish and Wildlife Safety. (Unpublished study received Jan 

5, 1978 under 1F1105; CDL:096705-A) 

05-Jan1978 

Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Acute Oral LD50--Bobwhite 

35237 Quail: Project No. 110-115. (Unpublished study received Jan 5, 1978 under 1F1105; 

prepared by Wildlife International, Ltd. in cooperation with Washington College, 

05-Jan1978 

submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096705-B) 

Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Eight-Day Dietary LC50--

35240 Bobwhite Quail: Project No. 110-112. (Unpublished study received Jan 5, 1978 under 

1F1105; prepared by Wildlife International, Ltd. in cooperation with Washington College, 

05-Jan1978 

submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096705-E) 

Fink, R.; Beavers, J.B.; Brown, R. (1977) Final Report: Eight-Day Dietary LC50--Mallard 

35241 Duck: Project No. 110-114. (Unpublished study received Jan 5, 1978 under 1F1105; 

prepared by Wildlife International, Ltd. in cooperation with Washington College, 

05-Jan1978 

submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096705-F) 

Union Carbide Corporation (1977) The Acute Toxicity of Hydrothol 191 to the Water 

35242 Flea, Daphnia magna Straus: UCES Project # 11506-41-05. (Unpublished study received 

Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, 

05-Jan1978 

Pa.; CDL:096705-G) 

Vilkas, A.G. (1977) The Acute Toxicity of Hydrothol 191 to the Fiddler Crab, Uca 

35244 pugilator: UCES Project # 11506-41-05. (Un - published study received Jan 5, 1978 under 

1F1105; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Agchem Div., 

05-Jan1978 

King of Prussia, Pa.; CDL:096705-I) 

127
35245 Pennwalt Corporation (1970) Beneficial Insect Safety. (Unpublished study received Jan 5, 

1978 under 1F1105; CDL:096705-K) 

05-Jan1978 

35434 Pennwalt Corporation (19) Product Chemistry: Data Requirements. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL: 096703 -I) 

05-Jan1978 

35436 

Pennwalt Corporation (1976) Analytical Procedure for Hydrothol 191 Liquid, Hydrothol 

191 Granular (Hydrothol 191 Rice Herbicide), and Herbicide 283. Method dated Apr 

1976. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-M) 

05-Jan1978 

35437 

Whitaker, R.L. (1977) Product Stability. (Unpublished study received Jan 5, 1978 under 

1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096703-

N) 

05-Jan1978 

35438 Pennwalt Corporation (1977) Stability of the Mono(N,N-Dimethylcocoamine) Salt of 

Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-O) 

05-Jan1978 

35442 

Pennwalt Corporation (1974) Results of Residue Determinations: Disappearance of 

Endothall in Water. (Unpublished study re- ceived Jan 5, 1978 under 1F1105; 

CDL:096703-S) 

05-Jan1978 

35443 

Pennwalt Corporation (1974) Results of Residue Determinations: Fish and Other Aquatic 

Organisms (Oysters, Clams, Crayfish, etc.). (Unpublished study received Jan 5, 1978 

under 1F1105; CDL:096703-T) 

05-Jan1978 

35453 Pennwalt Corporation (1954) Toxicology: Endothall. (Unpublished study received Jan 5, 

1978 under 1F1105; CDL:096703-AE) 

05-Jan1978 

Seaman, D.E.; Berkenkotter, P.; Chen, T.M. (1966) Herbicide residues and submersed 

35767 

weed control in California rice fields. Pages 34-36, In Proceedings of the Rice Technical 

Working Group; Jun 14-17, 1966, Little Rock, Arkansas. N.P. (Also in unpublished 

submission received Sep 19, 1971 under 1F1036; submitted by Monsanto Co., 

19-Sep1971 

Washington, D.C.; CDL:091921-J) 

Wacker-Chemie, GmbH (1973) Migration Properties of the Pesticide. A translation of: 

36530 

Versickerungsverhalten des Pflanzenbehang- lungsmittels. (Unpublished study including 

German text and letter dated Apr 19, 1977 from Wacker-Chemie, GmbH to Dr. Louis, 

received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-D) 

Watson, J.D. (1970) The Results of Tests on the Amount of Residue Remaining including 

36531 a Description of the Analytical Method Used: Endothall. (Unpublished study received Jan 

5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-F) 

Watson, J.D. (1972) The Results of Tests on the Amount of Residue Remaining, 

36532 Including a Description of the Analytical Method Used: Endothall. (Unpublished study 

received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of 

05-Jan1978 

Prussia, Pa.; CDL:096704-G) 

Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, 

36534 Including a Description of the Analytical Methods Used: Endothall. (Unpublished study 

received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of 

05-Jan1978 

Prussia, Pa.; CDL:096704-I) 

36535 

Frank, P.A.; Comes, R.D. (1967) Herbicidal residues in pond water and hydrosoil. Weeds 

15:210-213. (Also in unpublished submission received Jan 5, 1978 under 1F1105; 

submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-J) 

05-Jan1978 

21-Oct1982 

128
36537 

Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, 

Including a Description of the Analytical Method Used: Endothall. (Unpublished study 

received Jan 5, 1978 under 1F1105; CDL:096704-L) 

05-Jan1978 

36539 

Miller, H. (1975) Phytotoxicity: Phototoxicity to Irrigated Crops. (Unpublished study 

received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of 

Prussia, Pa.; CDL: 096704-N) 

05-Jan1978 

36542 

Latven, A.R. (1975) Accelerate (N.B. 58-196-3). (Unpublished study received Jan 5, 1978 

under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 

Agchem Div., King of Prussia, Pa.; CDL:096704-R) 

05-Jan1978 

Latven, A.R. (1976) Endothall Products, Dermal Toxicity after Limited Exposure. 

36549 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology 

Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 

05-Jan1978 

096704-AB) 

36551 

Latven, A.R. (1976) Hydout N.B. 77-23-6 (10.3% Endothall). (Unpublished study 

received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted 

by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-AD) 

05-Jan1978 

36553 

Latven, A.R. (1976) Accelerate N.B. 77-23-5 (5.5% Endothall). (Un- published study 

received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted 

by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-AF) 

05-Jan1978 

Paa, H. (1976) Report to Pennwalt Corporation: Acute Dermal Toxicity Study with 

36554 Hydrothol 191 in Albino Rabbits: IBT No. 8530-08497. (Unpublished study received Jan 

5, 1978 under 1F1105; prepared by Industrial Bio-Test Laboratories, Inc., submitted by 

05-Jan1978 

Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-AG) 

36557 

Latven, A.R. (1971) Accelerate. (Unpublished study received Jan 5, 1978 under 1F1105; 

prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Agchem Div., 

King of Prussia, Pa.; CDL:096704-AJ) 

05-Jan1978 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191 

36558 

Liquid (N.B. 77-100-2) on New Zealand Albino Rabbits: Laboratory No. 7E-5662. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-AK) 

Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Hydrothol 191 Liquid (N.B. 77­

36559 

100-2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5663. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-AL) 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5661. 

36560 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL: 096704-AN) 

36561 

Wise, M.T. (1977) Acute Inhalation Toxicity of a) Aquathol K (N.B. 77-100-4) b) 

Hydrothol 191 Liquid (N.B. 77-100-2) c) Hydrothol 47 Liquid (N.B. 77-100-3) d) 

Aquathol (N.B. 77-99-7) e) Des-I-Cate Accelerate (N.B. 77-99-6) f) Knox-Out(R)I 2 FM 

(N.B. 4414-94): Laboratory Nos. a) 7E-5660 b) 7E-5665 c) 7E-5670 d) 7E-5675 e) 7E5680 f) 7E-5685. (Un- published study received Jan 5, 1978 under 1F1105; prepared by 

Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, 

Pa.; CDL:096704-AO) 

26-Jul1977 

04-Oct1977 

05-Jan1978 

129
Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydrothol 

36577 

191 Granular (N.B. 77-99-2) on Abraded and Non-abraded Skin of New Zealand Albino 

Rabbits: Lab- oratory No. 7E-5694. (Unpublished study received Jan 5, 1978 under 

1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem 

05-Jan1978 

Div., King of Prussia, Pa.; CDL: 096704-BF) 

Becker, J.; Parke, G.S.E. (1977) Report: The Effects of Hydro- thol 191 Granular (N.B. 

36578 

77-99-2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5693. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-BG) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LDI50 of Hydrothol 191 

36579 

Granular (N.B. 77-99-2) on New Zealand Albino Rabbits: Laboratory No. 7E-5692. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-BH) 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5691. 

36580 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL: 096704-BI) 

Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Hydout TM (N.B. 77-99-5) on 

36585 the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5703. (Unpublished 

study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., 

05-Jan1978 

submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704-BN) 

Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydout 

36586 

TM (N.B. 77-99-5) on Abraded and Nona- braded Skin of New Zealand Albino Rabbits: 

Laboratory No. 7E- 5704. (Unpublished study received Jan 5, 1978 under 1F1105; 

prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King 

05-Jan1978 

of Prussia, Pa.; CDL:096704-BO) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydout TM (N.B. 

36587 77-99-5) on New Zealand Albino Rabbits: Laboratory No. 7E-5702. (Unpublished study 

received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, Inc., submitted by 

05-Jan1978 

Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096707-BP) 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5701. 

36588 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL: 096704-BQ) 

Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Des-I-Cate /Accelerate (N.B. 77­

36589 

99-6) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5678. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-BR) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Des-I36590 

Cate/Accelerate (N.B. 77-99-6) on New Zealand Albino Rabbits: Laboratory No. 7E5677. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

CDL:096704-BS) 

36591 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5676. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

05-Jan1978 

130
CDL: 096704-BT) 

Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77-99-4) 2. 

Hydrothol 191 Granular (N.B. 77- 99-2) 3. Hydrothol 47 Granular (N.B. 77-99-3) 4. 

36592 Hydout (N.B. 77-99-5): Laboratory Nos. 1. 7E-5690 2. 7E-5695 3. 7E-5700 4. 7E-5705. 

(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 

05-Jan1978 

Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 

CDL: 096704-BU) 

Pierre, F.S.; Parke, G.S.E. (1977) Report : A Primary Dermal Irritation Study of Des -I37848 

Cate /Accelerate (N.B. 77-99-6) on Abraded and Non-abraded Skin of New Zealand 

Albino Rabbits: Laboratory No. 7E-5679. (Unpublished study received Jan 5, 1978 under 

1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem 

05-Jan1978 

Div., King of Prussia, Pa.; CDL: 096704-BZ) 

40986 

Bowles, E.J.; Keckemet, O; Boyle, W.D.; et al. (1964) Hydrothol 191 as an Aquatic 

Herbicide in Flowing Water. (Unpublished study received Apr 10, 1966 under 6G0503; 

submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-AE) 

10-Apr1966 

42004 

Carlson, R.E. (1966) Letter sent J.D. Watson dated Feb 11, 1966: Analysis of Mixtures of 

Amine Endothall with Def and Folex. (Unpublished study received Apr 10, 1966 under 

6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-AD) 

10-Apr1966 

17-Feb1967 

46489 

Wakatsuki, J.; Wachi, G.; Oudman, L.; et al. (1975) Ripenthol Reports. (Reports by 

various sources; unpublished study received Oct 21, 1975 under 4581-EX-19; submitted 

by Pennwalt Corp., Philadelphia, Pa.; CDL:243211-A) 

21-Oct1975 

49658 

Pennwalt Corporation (1966) Toxicity Study: Hydrothal on Fish. (Reports by various 

sources; unpublished study received Jun 25, 1971 under unknown admin. no.; 

CDL:132475-F) 

25-Jun1971 

51466 

Lapham, V.T. (1966) Letter sent to W. Harry Culver dated Jun 24, 1966 Fish Kills. 

(Louisiana, Wild Life and Fisheries Commission, Aquatic Vegetation Control Research, 

unpublished study; CDL:132475-B) 

25-Jun1971 

51467 

Frank, P.A. (1964) Letter sent to Edward J. Bowles dated Oct 30, 1964 Hydrothol 

treatment of aquatic weeds. (U.S. Agricul- tural Research Service, Crops Research Div., 

Crop Protection Research Branch, unpublished study; CDL:132475 -C) 

25-Jun1971 

51468 

Zarbock, W.M. (1961) Letter sent to Harold Lindaberry dated Sep 20, 1961 TD191 on 

weeds and fish. (Ohio, Div. of Wildlife, Dept. of Natural Resources, unpublished study; 

CDL: 132475-D) 

25-Jun1971 

51469 

Brown, C.L. (1966) Letter sent to Edward Bowles dated Sep 22, 1966 Hydrothol on 

weeds and fish. (Glenn and Colusa Counties (California), Irrigation District, unpublished 

study; CDL:132475-H) 

25-Jun1971 

Latven, A.R. (1975) Letter sent to Obren Keckemet dated Jun 26, 1975 Toxicological 05-Oct51589 findings with alcoholic Ripenthol and aqueous Ripenthol. (Unpublished study received 

Oct 5, 1976 under 4581-173; prepared by Pharmacology Research, Inc., submitted by 

1976 

05-JanPennwalt Corp., Philadelphia, Pa.; CDL:226503-B) 1978 

Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydrothol 

52457 

191 Liquid (N.B. 77-100-2) on Abraded and Non-abraded Skin of New Zealand Albino 

Rabbits; Laboratory No. 7E-5664. (Unpublished study received Jan 5, 1978 under 

1F1105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem 

05-Jan1978 

Div., King of Prussia, Pa.; CDL: 096704-AM) 

52823 Seaman, D.E.; De Witt, J.R.; Beeman, H.D., Jr.; et al. (1975) Re- ports of Experimental 16-Oct131
Use of Hydrothol 119 Rice Herbicide. (Reports by various sources; unpublished study 1975 

received Oct 16, 1975 under 4581-EX-21; submitted by Pennwalt Corp., Philadelphia, 

Pa.; CDL:243209-A) 

05-Jan1972 

08-Feb55700 

Frank, P.A.; Comes, R.D. (1967) Herbicidal residues in pond water and hydrosoil. Weeds 

15(3):210-213. (Also in unpublished sub- mission received Aug 4, 1976 under 876-222; 

submitted by Velsicol Chemical Corp., Chicago, Ill.; CDL:229172-F) 

1973 

04-Aug1976 

22-Aug1977 

21-Dec1982 

56395 

Hestand, R.S., III; Carter, C.C. (1967) Herbicide Effects on Aqua- tic Plants. 

(Unpublished study received Dec 19, 1975 under 6H5112; submitted by 3M Co., St. Paul, 

Minn.; CDL:230414-C) 

19-Dec1975 

56396 

Hestand, R.S., III; Carter, C.C. (1968) Herbicide Effects on Phytoplankton. (Unpublished 

study received Dec 19, 1975 under 6H5112; submitted by 3M Co., St. Paul, Minn.; 

CDL:230414-D) 

19-Dec1975 

58566 

Keckemet, O. (1973) The Name, Chemical Identity, and Composition of the Pesticide 

Chemical: Endothall. (Unpublished study received Feb 1, 1975 under 3F1416; submitted 

by Pennwalt Corp., Tacoma, Wash.; CDL:093785-A) 

01-Feb1975 

58567 

Pennwalt Corporation (1973) Analytical Procedure for Hydrothol 191 and Hydrothol 191 

Rice Herbicide. Method dated May 1973. (Un- published study received Feb 1, 1975 

under 3F1416; CDL:093785-C) 

01-Feb1975 

58569 

Pennsalt Chemicals Corporation (1968) Product Specification 5-9224. (Unpublished study 

received Feb 1, 1975 under 3F1416; submitted by Pennwalt Corp., Tacoma, Wash.; 

CDL:093785-E) 

01-Feb1975 

58570 

Pennwalt Corporation (1973) Efficacy of Hydrothol 191 on Rice. (Compilation; 

unpublished study, including published data, received Feb 1, 1975 under 3F1416; 

CDL:093785-F) 

01-Feb1975 

Latven, A.R. (1971) Accelerate. (Unpublished study, including letter dated Sep 29, 1971 

58572 from A.R. Latven to Harold L. Linda- berry, received Feb 1, 1975 under 3F1416; 

prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, Wash.; 

01-Feb1975 

CDL:093785-K) 

Latven, A.R. (1971) Accelerate. (Unpublished study, including letter dated Oct 15, 1971 

58573 from A.R. Latven to Harold L. Lindaberry, received Feb 1, 1975 under 3F1416; prepared 

by Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, Wash.; 

01-Feb1975 

CDL:093785-L) 

Keckemet, O. (1973) The Results of Tests on the Amount of Residue Remaining, 

58574 Including a Description of the Analytical Method Used: Endothall. (Unpublished study 

received Feb 1, 1975 under 3F1416; submitted by Pennwalt Corp., Tacoma, Wash.; CDL: 

01-Feb1975 

093785-M) 

Latven, A.R. (1975) Toxicology Report for Pennwalt Agchem Division: Ripenthol N.B. 

61919 58-188-3 (Isopropyl-butanol Formulation). (Un- published study received Oct 5, 1976 

under 4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 

05-Oct1976 

Philadelphia, Pa.; CDL:227610-C) 

132
Latven, A.R. (1975) Toxicology Report for Pennwalt Agchem Division: Ripenthol N.B. 

61920 58-191-2 (Water Only Formulation). (Unpublished study received Oct 5, 1976 under 

4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 

05-Oct1976 

Philadel- phia, Pa.; CDL:227610-D) 

Pennwalt Corporation (1975) Analytical Procedure for Hydrothol 191 Liquid (Ripenthol), 

67024 Hydrothol 191 Granular (Hydrothol 191 Rice Herbicide) and Herbicide 283. Method 

dated Jan 1975. (Unpublished study received Feb 1, 1975 under 4581-EX-21; CDL: 

01-Feb1975 

094575-C) 

67025 

Pennsalt Chemicals Corporation (1968) Hydrothol 191 Rice Herbicide: Product 

Specification 5-9224. (Unpublished study received Feb 1, 1975 under 4581-EX-21; 

submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa., CDL:094575-E) 

01-Feb1975 

67723 Pennsalt Chemical Corporation (1967) Chemical Data Regarding Des-i-cate. 

(Compilation; unpublished study received May 8, 1967 under 7G0608; CDL:092900-A) 

08-May1967 

Watson, J.D. (1967) The Results of Tests on the Amount of Residue Remaining, 

67724 Including a Description of the Analytical Method Used: Des-i-cate. (Unpublished study 

received May 8, 1967 under 7G0608; submitted by Pennsalt Chemica l Corp., Agricultural 

08-May1967 

Chemicals Div., Aurora, Ill.; CDL:092900-B) 

67725 

Watson, J.D. (1967) Reasonable Grounds in Support of the Petition: Des -i-cate. 

(Compilation; unpublished study received May 8, 1967 under 7G0608; submitted by 

Pennsalt Chemical Corp., Agricultural Chemicals Div., Aurora, Ill.; CDL:092900-C) 

08-May1967 

67763 

Keckemet, O. (1975) Reasonable Grounds in Support of the Petition for Residue 

Tolerance: Endothall. (Unpublished study received Feb 1, 1975 under 4581-EX-21; 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:094575-F) 

01-Feb1975 

67764 

Keckemet, O. (1975) Full Reports and Data of Investigation Made on the Effectiveness of 

the Product: Endothall. (Unpublished study received Feb 1, 1975 under 4581-EX-21; 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:094575-H) 

01-Feb1975 

69049 Pennwalt Corporation (1979) Phytotoxicity Summary. (Compilation; unpublished study 

received Jan 23, 1981 under 1F1105; CDL: 099882-A) 

23-Jan1981 

Moreno, M.T.; Moreno, O.M. (1979) Test for Guinea Pig Sensitization: Project No. MB 

69052 79-4140. (Unpublished study, including letter dated Dec 19, 1979 from O.M. Moreno to 

Obren Keckemet, received Jan 23, 1981 under 1F1105; prepared by MB Research 

23-Jan1981 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099882-D) 

Moreno, M.T.; Moreno, O.M. (1979) Test for Guinea Pig Sensitization: Project No. MB 

70572 79-4140. (Unpublished study, including letter dated Dec 19, 1979 from O.M. Moreno to 

Obren Keckemet, received Jan 23, 1981 under 4581-204; prepared by MB Research 

23-Jan1981 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244126-C) 

71130 

Pennwalt Corporation (1979) Fish and Wildlife Safety Summary. Summary of studies 

244131-B through 222131-R. (Unpublished study received Jan 23, 1981 under 4581-174; 

CDL:244131-A) 

23-Jan1981 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow 

71132 Trout, Salmo gairdneri Richardson: UCES Project No. 11506-41-17. (Unpublished study 

received Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted by 

23-Jan1981 

Pennwalt Corp., Philadelphia, Pa.; CDL:244131-D) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd- out(TM) Aquatic Weed 

71133 Killer Code AHE 09H901, N.B. No. 84-112-1 to the Rainbow Trout Salmo gairdneri 

Richardson: UCES Project No. 11506-41-20. (Unpublished study, including letters dated 

23-Jan1981 

Feb 7, 1980 from O. Keckemet to Agchem File and Jan 18, 1980 from A.G. Vilkas to 

133
B.D. McGaughey, received Jan 23, 1981 under 4581-174; prepared by Union Carbide 

Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-E) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Bluegill 

71135 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506-41-18. (Unpublished 

study received Jan 23, 1981 under 4581 -174; prepared by Union Carbide Corp., submitted 

23-Jan1981 

by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-G) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd- out(TM) Aquatic Weed 

Killer Code AHE 09H901, N.B. No. 84-112-1 to the Bluegill Sunfish, Lepomis 

71136 macrochirus Rafinesque: UCES Project No. 11506-41-19. (Unpublished study, including 

letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 

23-Jan1981 

4581-174; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, 

Pa.; CDL:244131-H) 

Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active) 

71139 

(Sample Code 84-112-1; Lot AHE 09H9-01) to the Water Flea Daphnia magna Straus: 

UCES Project No. 11506-41-22. (Unpublished study, including letter dated Feb 7, 1980 

from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581- 174; prepared by 

23-Jan1981 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-K) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient 

71140 

to the Grass Shrimp Palaemonetes pugio: USES Project No. 11506-41-23. (Unpublished 

study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 

23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted by Pennwalt 

23-Jan1981 

Corp., Philadelphia, Pa.; CDL:244131-M) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd-out Aquatic Weed Killer 

Code AHE 09H901, N.B. No. 84-112-1 to the Fiddler Crab, Uca pugilator: UCES Project 

71141 No. 11506-41- 24. (Unpublished study, including letters dated Jan 18, 1980 from A.G. 

Vilkas to B.D. McGaughey and Feb 7, 1980 from O. Keckemet to Agchem File, received 

23-Jan1981 

Jan 23, 1981 under 4581-174; pre- pared by Union Carbide Corp., submitted by Pennwalt 

Corp., Philadelphia, Pa.; CDL:244131-N) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient 

71144 

to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506-

41-21. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to 

Agchem File, received Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp., 

23-Jan1981 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-Q) 

Hestand, R.S., III (1974) Letter sent to Johnnie L. Frizzell dated Sep 27, 1974 Rough data 

71146 on efficacy and toxicity of TD-1874 and Hydrothol 191. (Florida, Game and Fresh Water 

Fish Comission; unpublished study, including letter dated Sep 26, 1974 from R.S. 

23-Jan1981 

Hestand, III to Johnnie L. Frizzell; CDL:244131-T) 

71147 

U.S. Department of Interior, Bureau of Reclamation (1963) Results of Algaecidal 

Evaluation Tests of Selected Compounds: Report No. WC-21. (Pages 26-32 only in 

Annual Progress Report of 1964 Lab. Studies; unpublished study; CDL:244131-U) 

23-Jan1981 

71148 

Pennwalt Corporation (1980) Hydout Aquatic Algicide and Herbicide--Pellet State versus 

Toxicity: Project No. WT-4-80. (Unpublished study received Jan 23, 1981 under 4581­

174; CDL: 244131-V) 

23-Jan1981 

71745 Pennwalt Corporation (1978) Residue Chemistry: Results of Residue Determinations. 

(Unpublished study received Jan 23, 1981 under 4581-282; CDL:244121-A) 

23-Jan1981 

71746 Pennwalt Corporation (1979) Hydout Aquatic Herbicide--Release Rate: Project No. WT13-79. (Unpublished study received Jan 23, 1981 under 4581-282; CDL:244121-B) 

23-Jan1981 

134
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow 

72456 Trout, Salmo gairdneri Richardson: UCES Project No. 11506-41-17. (Unpublished study 

received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by 

23-Jan1981 

Pennwalt Corp., Philadelphia, Pa.; CDL:099883-D) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Bluegill 

72458 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506-41-18. (Unpublished 

study received Jan 23, 1981 under 1F1105; prepared by Un ion Carbide Corp.; submit- ted 

23-Jan1981 

by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-G) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd-out Aquatic Weed Killer 

Code AHE 09H901, N.B. No. 84-112-1 to the Bluegill Sunfish Lepomis macrochirus 

72459 Rafinesque: UCES Project No. 11506-41-19. (Unpublished study, including letter dated 

Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 1F1105; 

23-Jan1981 

prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; 

CDL:099883-H) 

Vilkas, A.G.; Hughes, J.S. (1979) The Acute Toxicity of Endothall (Acid Monohydrate) 

72460 to the Water Flea Daphnia magna Straus: UCES Project No. 11506-41-09. (Unpublished 

study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted 

23-Jan1981 

by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-I) 

Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active) 

72461 

(Sample Code 84-112-1; Lot AHE 09H9-01) to the Water Flea Daphnia magna St raus: 

UCES Project No. 11506-41-22. (Unpublished study received Jan 23, 1981 under 1F1105; 

prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; 

23-Jan1981 

CDL:099883-K) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient 

72462 

to the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506-41-23. (Unpublished 

study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 

23, 1981 under 1F1105; prepared by Union Car- bide Corp., submitted by Pennwalt Corp., 

23-Jan1981 

Philadelphia, Pa.; CDL: 099883-M) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd-out Aquatic Weed Killer 

Code AHE 09H901, N.B. No. 84-112-1 to the Fiddler Crab, Uca pugilator: UCES Project 

72463 No. 11506-41- 24. (Unpublished study, including letters dated Feb 7, 1980 from O. 

Keckement to Agchem File and Jan 18, 1980 from A.G. Vilkas to B.D. McGaughey, 

23-Jan1981 

received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by 

Pennwalt Corp., Philadelphia, Pa.; CDL:099883-N) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient 

72466 

to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506-

41-21. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to 

Agchem File, received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., 

23-Jan1981 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-Q) 

72550 

Pennwalt Corporation (1980) Efficacy Introduction: Hydout Aquatic Algicide and 

Herbicide. (Compilation; unpublished study received Jan 23, 1981 under 4581-EX-32; 

CDL:244117-A) 

23-Jan1981 

Moreno, M.T.; Moreno, O.M. (1979) Test for Guinea Pig Sensitiza - tion: Project No. MB 

73370 79-4140. (Unpublished study, including letter dated Dec 19, 1979 from O.M. Moreno to 

Obren Keckemet, received Jan 23, 1981 under 4581-174; prepared by MB Research 

23-Jan1981 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244123-C) 

74221 

Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active) 

(Sample Code 84-112-1; Lot AHE 09H9-01) to the Water Flea Daphnia magna Straus: 

UCES Project No. 11506-41-22. (Unpublished study, including letter dated Feb 7, 1980 

23-Jan1981 

135
from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581- 282; prepared by 

Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-K) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient 

74222 

to the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506-41-23. (Unpublished 

study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 

23, 1981 under 4581-282; prepared by Union Carbide Corp., submitted by Pennwalt 

23-Jan1981 

Corp., Philadelphia, Pa.; CDL:244122-M) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hy -dout Aquatic Weed Killer, 

Code AHE 09H901, N.B. No. 84- 112-1, to the Fiddler Crab, Uca pugilator: UCES 

74223 Project No. 11506-41-24. (Unpublished study, including letters dated Jan 18, 1980 from 

A.G. Vilkas to B.D. Mc Gaughey and Feb 7, 1980 from O. Keckemet to Agchem File, 

23-Jan1981 

received Jan 23, 1981 under 4581-282; prepared by Union Carbide Corp., submitted by 

Pennwalt Corp., Philadelphia, Pa.; CDL:244122-N) 

Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active 

74226 

Ingredient, to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project 

No. 11506-41-21. (Unpublished study, including letter dated Feb 7, 1980 from O. 

Keckemet to Agchem File, received Jan 23, 1981 under 4581-282; prepared by Union 

23-Jan1981 

Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-Q) 

74229 

U.S. Department of the Interior, Bureau of Reclamation (1964) Results of Algaecidal 

Evaluation Tests of Selected Compounds: Report No. WC-21. (Unpublished study; 

CDL:244122-U) 

23-Jan1981 

Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology 

78180 reports on seven products. (Unpublished study received Jan 5, 1978 under 4581-174; 

prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 

05-Jan1978 

Pa.; CDL:232580-B) 

Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Accelerate (N.B. 

78182 58-196-3). (Unpublished study received Jan 5, 1978 under 4581-174; prepared by 

Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 

05-Jan1978 

232580-D) 

Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Ripenthol N.B. 

78188 58-188-3 (Isopropyl-butanol Formulation). (Unpublished study received Jan 5, 1978 

under 4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 

05-Jan1978 

Philadelphia, Pa.; CDL:232580-K) 

Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Ripenthol N.B. 

78189 58-191-2 (Water Only Formulation). (Unpublished study received Jan 5, 1978 under 

4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 

05-Jan1978 

Philadelphia, Pa.; CDL:232580-L) 

Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Ripenthol N.B. 

78190 

58-191-2 (23.4%). (Unpublished study, including letter dated Aug 14, 1975 from A.R. 

Latven to Obren Kechemet, received Jan 5, 1978 under 4581-174; prepared by 

Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

05-Jan1978 

CDL:232580-M) 

Latven, A.R. (1976) Letter sent to Obren Keckemet dated Jan 29, 1976 Toxicological 

78191 study reports on endothall products. (Un- published study received Jan 5, 1978 under 

4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 

05-Jan1978 

Philadelphia, Pa.; CDL:232580-N) 

78192 Latven, A.R. (1976) Toxicology Report for Pennwalt, Agchem Division: Endothall 

Products, Dermal Toxicity after Limited Expo- sure. (Unpublished study received Jan 5, 

05-Jan1978 

136
1978 under 4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt 

Corp., Philadelphia, Pa.; CDL:232580-O) 

Latven, A.R. (1976) Toxicology Report For Pennwalt, Agchem Division: Hydout N.B. 

78194 77-23-6 (10.3% Endothall). (Unpublished study received Jan 5, 1978 under 4581 -174; 

prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 

05-Jan1978 

Pa.; CDL:232580-Q) 

Latven, A.R. (1976) Toxicology Report for Pennwalt, Agchem Division: Accelerate N.B. 

78196 77-23-5 (5.5% Endothall). (Unpublished study received Jan 5, 1978 under 4581-174; 

prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 

05-Jan1978 

Pa.; CDL:232580-S) 

78199 

Latven, A.R. (1971) Toxicology Report for Pennwalt Corporation: Ac- celerate. 

(Unpublished study received Jan 5, 1978 under 4581- 174; prepared by Pharmacology 

Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232 580-W) 

05-Jan1978 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191 

78200 Liquid (N.B. 77-100-2) on New Zealand Albino Rabbits: Laboratory No. 7E-5662. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

05-Jan1978 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-X) 

78201 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab- oratory No. 7E-5661. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-AA) 

05-Jan1978 

Wise, M.T. (1977) Acute Inhalation Toxicity of Aquathol K (N.B. 77-100-4); Hydrothol 

191 Liquid (N.B. 77-100-2); Hydrothol 47 Liquid (N.B. 77-100-3); Aquathol (N.B. 77­

78202 99-7); Des-i-cate Accelerate (N.B. 77-99-6); Knox- out 2 FM (N.B. 4414-94): Laboratory 

Nos. 7E-5660; 7E-5665; 7F-5670; 7E-5675; 7E-5680; 7E-5685. (Unpublished study 

05-Jan1978 

received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., submitted 

by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-AB) 

St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of 

78217 

Hydrothol 191 Granular (N.B. 77-99-2) on Abraded and Non-abraded Skin of New 

Zealand Albino Rabbits: Laboratory No. 7E-5694. (Unpublished study received Jan 5, 

1978 under 4581-174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt 

05-Jan1978 

Corp., Philadelphia, Pa.; CDL:232580-AS) 

Becker, J.; Parke, G.S.E. (1977) Report: The Effects of Hydrothol 191 Granular (N.B. 77­

78218 99-2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5693. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

05-Jan1978 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-AT) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191 

78219 Granular (N.B. 77-99-2) on New Zealand Albino Rabbits: Laboratory No. 7E-5692. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

05-Jan1978 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-AU) 

78220 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab- oratory No. 7E-5691. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-AV) 

05-Jan1978 

St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Hydout (N.B. 77-99-5) on the 

78603 Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5703. (Unpublished 

study received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., 

05-Jan1978 

submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-BA) 

78604 St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydout 05-Jan137
(N.B. 77-99-5) on Abraded and Non-abraded Skin of New Zealand Albino Rabbits: 1978 

Laboratory No. 7E- 5704. (Unpublished study received Jan 5, 1978 under 4581-174; 

prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 

CDL:232580-BB) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydout (N.B. 77-99-

78605 5) on New Zealand Albino Rabbits: Laboratory No. 7E-5702. (Unpublished study 

received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., submitted 

05-Jan1978 

by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BC) 

78606 

Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab- oratory No. 7E-5701. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BD) 

05-Jan1978 

St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Des-i-cate /Accelerate (N.B. 

78607 77-99-6) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5678. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

05-Jan1978 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BE) 

Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Des-i-cate 

78608 /Accelerate (N.B. 77-99-6) on New Zealand Albino Rabbits: Laboratory No. 7E-5677. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

05-Jan1978 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-BF) 

78609 

Terrell, Y; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5676. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BG) 

05-Jan1978 

Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77-99-4); 2. 

78610 

Hydrothol 191 Granular (N.B. 77-99-2); 3. Hydrothol 47 Granular (N.B. 77-99-3); 4. 

Hydout (N.B. 77-99-5): Laboratory Nos. 7E-5690; 7E- 5695; 7E-5700; 7E-5705. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

05-Jan1978 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BH) 

St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Des-i78614 

cate /Accelerate (N.B. 77-99-6) on Abraded and Non-abraded Skin of New Zealand 

Albino Rabbits: Laboratory No. 7E-5679. (Unpublished study received Jan 5, 1978 under 

4581-174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., 

05-Jan1978 

Philadelphia, Pa.; CDL:232580-BM) 

Pennsalt Chemicals Corporation (1966) Summary of Justification: Disodium Endothall. 

80436 Summary of studies 090585-B through 090585-F. (Unpublished study received on 

unknown date under 6G0503; CDL:090585-A) 

80438 Pennsalt Chemicals Corporation (1966) Endothall Residue--Cotton. (Compilation; 

unpublished study received on unknown date under 6G0503; CDL:090585-C) 

Carlson, R.E. (1966) Letter sent to J.D. Watson dated Feb 11, 1966: Analysis of mixtures 

80440 of amine endothall with Def and Folex. (Unpublished study received on unknown date 

under 6G0503; submitted by Pennsalt Chemicals Corp., Tacoma, Wash.; CDL:090585-F) 

83032 Pennwalt Corporation (1979) Fish and Wildlife Safety: Summary. (Unpublished study 

received Mar 25, 1981 under 4581 -223; CDL: 244664-A) 

25-Mar1981 

25-Mar83033 Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 

244662-B. (Unpublished study received Mar 25, 1981 under 4581-223; CDL:244662-A) 

1981 

14-Sep1981 

83034 Pennwalt Corporation (1979) Drift of Endothall Sprays and Their Phytotoxic Effects on 25-Mar138
Non-target Plant Species: Project No. WT- 8-78. (Unpublished study received Mar 25, 1981 

1981 under 4581-223; CDL:244662-B) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow 

84147 

Trout, Salmo gairdneri Richardson: UCES Project No. 11506-41-17. (Unpublished study, 

including letters dated Jan 18, 1980 from A.G. Vilkas to B.D. McGaughey and Feb 7, 

1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581-282; prepared 

23-Jan1981 

by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-D) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Bluegill 

84148 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506-41-18. (Unpublished 

study received Jan 23, 1981 under 4581 -282; prepared by Union Carbide Corp., submitted 

23-Jan1981 

by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-G) 

Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydout Aquatic Weed Killer 

Code AHE 09H901, N.B. No. 84- 112-1 to the Bluegill Sunfish Lepomis macrochirus 

84149 Rafinesque: UCES Project No. 11506-41-19. (Unpublished study, including letter dated 

Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581-282; 

23-Jan1981 

prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 

CDL:244122-H) 

84382 

Seaman, D.E.; Berkenkotter, P.; Chen, T.M.; et al. (1966) Persistence of Residues and 

Fates of Herbicides in Rice Fields and in Rice-field Effluents: Progress report. WRC 

Project No. W 3 02 67. for the period Mar 1, 1965 to Jan 31, 1966. (Unpublis hed study 

received Oct 8, 1981 under 476-2107; prepared by Univ. of California--Davis, Dept. of 

Botany, submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:246011-M) 

08-Oct1981 

14-Oct1983 

St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Hydrothol 191 Liquid (N.B. 77­

84474 100-2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5663. 

(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 

05-Jan1978 

Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-Y) 

St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of 

84475 

Hydrothol 191 Liquid (N.B. 77-100-2) on Abraded and Non-abraded Skin of New 

Zealand Albino Rabbits: Laboratory No. 7E-5664. (Unpublished study received Jan 5, 

1978 under 4581-174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt 

05-Jan1978 

Corp., Philadelphia, Pa.; CDL:232580-Z) 

84604 

Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012-J 

through 246012-P. (Unpublished study received Sep 14, 1981 under 4581-349; 

CDL:246012-B) 

14-Sep1981 

Inglis, A.; Davis, E.L. (1972) Effects of Water Hardness on the Toxicity of Several 

85213 Organic and Inorganic Herbicides to Fish. By U.S. Fish and Wildlife Service, FishPesticide Research Laboratory. Washington, D.C.: USFWS. (Technical papers of the 

08-Dec1977 

Bureau of Sport Fisheries and Wildlife 67; published study; CDL: 232666-L) 

96292 

Eibert, J., Jr. (1967) Acute Dermal Toxicity (LDI50) in Rabbits: S.A. No. 127387. 

(Unpublished study received Feb 17, 1967 under 7F0570; prepared by Scientific 

Associates, Inc., submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719-C) 

17-Feb1967 

20-Dec1983 

96293 

Eibert, J., Jr. (1967) Dermal Irritation in Rabbits: S.A. No. 127388. (Unpublished study 

received Feb 17, 1967 under 7F0570; prepared by Scientific Associates, Inc., submitted 

by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719-D) 

17-Feb1967 

20-Dec1983 

96295 Walker, C.R. (1963) Letter sent to Harold L. Lindaberry dated Nov 8, 1963 Fish toxicity 

studies. (U.S. Fish and Wildlife Serv- ice, Fish Control Laboratory; unpublished study; 

23-Mar1967 

139
CDL:090719-G) 

96296 

Cope, O.B. (1966) Letter sent to Edward J. Bowles dated Sep 1, 1966 Fish toxicity of 

Des-i-cate (Accelerate). (U.S. Fish and Wildlife Service, Fish-Pesticide Research 

Laboratory; unpublished study; CDL:090719-H) 

23-Mar1967 

96297 

Pennsalt Chemicals Corporation (1967) Toxicity to Fish: Accelerate, Accelerate + Folex, 

and Accelerate + Sodium Chlorate. (Unpublished study received Feb 17, 1967 under 

7F0570; CDL:090719-I) 

17-Feb1967 

96301 

Pennsalt Chemicals Corporation (1967) The Results of Tests on the Amount of Residue 

Remaining, Including a Description of the Analytical Method Used: Accelerate. 

(Compilation; unpublished study received Feb 17, 1967 under 7F0570; CDL:090719-N) 

17-Feb1967 

96303 Pennsalt Chemicals Corporation (1967) Efficacy of Accelerate to Cotton. (Compilation; 

unpublished study received Feb 17, 1967 under 7F0570; CDL:090719-S) 

17-Feb1967 

101732 

Pennwalt Corp. (1963) Chemical Studies of Endothall Technical, Accelerate and Des-icate. (Compilation; unpublished study received Oct 30, 1963 under 4581-284; 

CDL:007455-A) 

30-Oct1963 

Pennwalt Corp. (1966) Efficacy of Accelerate, Des-i-cate and Other Compounds for 

101733 Defoliation of Cotton. (Compilation; unpublished study received on unknown date under 

4581-284; CDL:007455-B) 

101734 

Pennwalt Corp. (1954) Full Reports of Investigations Made with Respect to the Safety of 

the Product: Disodium Endothall. (Un- published study received Oct 30, 1963 under 

4581-284; CDL: 007455-C) 

30-Oct1963 

Eibert, J. (1966) Summary of Safety Evaluation and Other Animal Studies on Disodium 

101735 Endothall. (Unpublished study received on unknown date under 4581-284; prepared by 

Scientific Associates, Inc., submitted by Pennwalt Corp., Philadelphia, PA; CDL: 007455­

D) 

Inglis, A.; Davis, E. (1968) The Effect of Water Hardness on the Toxicity to Fish of 

102626 

Several Organic and Inorganic Herbicides. (Unpublished paper presented at the 8th 

meeting of the Weed Society of America, Feb 5-8, 1968, New Orleans, LA; unpublished 

study received Jul 18, 1972 under 2E1221; submitted by U.S. Dept. of the Army, 

18-Jul1972 

Washington, DC; CDL:091051-R) 

113927 

Agchem (1966) Description of Analytical Methods and Results of Analyses for 

Dimethylcocoamine Endothall (Accelerate) in Cottonseed. (Compilation; unpublished 

study received Feb 14, 1966 under 4581-284; CDL:007456-A) 

14-Feb1966 

113931 

Agchem (1970) A Special Study on Residues of Endothall on Lint and Seed from Cotton 

Treated with Accelerate. (Unpublished study received Dec 15, 1970 under 0F0972; 

CDL:091670-D) 

15-Dec1970 

113936 Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 

(Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094507-A) 

01-Dec1970 

28-Apr113953 

Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining, 

Including a Description of the Analytical Method Used: Endothall. (Compilation; 

unpublished study received May 13, 1972 under 1F1105; CDL:094506-H) 

1972 

04-May1972 

13-May1972 

113954 Pennwalt Corp. (1971) A Report of Two Studies on Residues in Potatoes and Soil after 

Treatment with Endothall and 14C Endothall Formulated as DES -I-CATE. (Compilation; 

140
unpublished study received on unknown date under 1F1057; CDL:093370 -A) 

29-NovLatven, A. (1971) Accelerate: Summary--Acute Dermal Toxicity in Rabbits: Nontoxic at 1971 

113955 250 MG/KG. (Unpublished study received Nov 29, 1971 under 1F1057; prepared by 

Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:093370-

09-Jul1975 

C) 20-Dec1983 

Latven, A. (1971) Accelerate: Summary--Eye Irritancy in Rabbits: Corneal Opacification, 

113956 Iridal Congestion, Conjunctival Inflammation and Chemosis. (Unpublished study received 

Nov 29, 1971 under 1F1057; prepared by Pharmacology Research, Inc., submitted by 

29-Nov1971 

Pennwalt Corp., Tacoma, WA; CDL:093370-D) 

113957 

Pennwalt Corp. (1971) Name, Chemical Identity and Composition of Pesticide Chemical: 

Endothall. (Compilation; unpublished study received Jan 20, 1971 under 1F1057; 

CDL:093370-E) 

20-Jan1971 

113958 

Pennwalt Corp. (1971) The Amount, Frequency, and Time of Application of the Pesticide 

Chemical: Endothall. (Compilation; un- published study received Jan 20, 1971 under 

1F1057; CDL: 093370-F) 

20-Jan1971 

113966 

Pennwalt Corp. (1974) The Results of Tests on the Amount of Residue Remaining, 

Including a Description of the Analytical Method Used: Endothall. (Compilation; 

unpublished study received May 1, 1974 under 4G1510; CDL:094009-A) 

01-May1974 

113967 

Pennwalt Corp. (1975) The Results of Tests on the Amount of Residue Remaining, 

Including a Description of the Analytical Methods Used: Endothall. (Compilation; 

unpublished study received Feb 1, 1975 under 3F1416; CDL:093784-A) 

01-Feb1975 

113968 

Pennwalt Corp. (1974) The Name, Chemical Identity, and Composition of the Pesticide 

Chemical: Endothall. (Compilation; unpublished study received May 1, 1974 under 

4G1510; CDL:094010-A) 

01-May1974 

113969 

Pennwalt Corp. (1974) The Amount, Frequency, and Time of Application of the Pesticide 

Chemical: Endothall. (Compilation; unpublished study received May 1, 1974 under 

4G1510; CDL: 094010-B) 

01-May1974 

113971 

Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of 

the Product: Endothall. (Compilation; unpublished study received on unknown date under 

1F1105; CDL:094509-A) 

03-May1971 

Latven, A. (1971) Accelerate: Summary--Acute Oral Toxicity in Starved Rats: LD50 = 

113972 650 MG/KG (0.57 ML/KG). (Unpublished study received Nov 29, 1971 under 4581-284; 

prepared by Pharmacology Research, Inc., submitted by Agchem Div., Pennwalt Corp., 

29-Nov1971 

Philadelphia, PA; CDL:100915-A) 

Walker, C. (1961) The Toxicology, Residue, Degradation, and Effectiveness of Disodium 08-Jul113983 Endothal and the Dimethyleocoamine Derivative as Aquatic Herbicides in Fisheries 

Habitat. (Unpublished study received Jul 8, 1965 under 4581-232; submitted by Agchem 

1965 

15-MarDiv., Pennwalt Corp., Philadelphia, PA; CDL:121844-S) 1966 

113987 

Agchem (1970) The Results of Tests on the Amount of Residue Remaining Including a 

Description of the Analytical Method Used: Endothall. (Compilation; unpublis hed study 

received Jun 27, 1971 under unknown admin. no.; CDL:124882-A) 

27-Jun1971 

114487 

Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and 

Complete Composition of the Product: Endothall. (Compilation; unpublished study 

received Jul 9, 1975 under 1F1105; CDL:094700-A) 

09-Jul1975 

141
114488 

Pennwalt Corp. (1975) Full Reports and Data of Investigations Made on the Safety of the 

Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study 

received Jul 9, 1975 under 1F1105; CDL:094702-A) 

09-Jul1975 

Latven, A. (1971) Accelerate: Summary--Acute Oral Toxicity in Starved Rats: LD50 = 

114491 650 Mg/Kg (0.57 Ml/Kg). (Unpublished study received Jul 9, 1975 under 1F1105; 

prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, WA; 

09-Jul1975 

CDL: 094702-D) 

114492 

Pennwalt Corp. (1972) Responses of Plankton and Macrofauna Communities To Test 

Application of Chemical Herbicides. (Unpublished study received Jul 9, 1975 under 

1F1105; CDL:094702-H) 

09-Jul1975 

114499 Pennwalt Corp. (1962) Chemical and Physical Properties: Endothall. (Compilation; 

unpublished study received Jul 9, 1975 under 1F1105; CDL:094706-A) 

09-Jul1975 

114500 Pennwalt Corp. (1975) Toxicity: Endothall. (Compilation; unpublished study received Jul 

9, 1975 under 1F1105; CDL:094706-B) 

09-Jul1975 

114501 Pennwalt Corp. (1974) Residues: Endothall. (Unpublished study received Jul 9, 1975 

under 1F1105; CDL:094706-C) 

09-Jul1975 

114504 Pennwalt Corp. (1975) Duration of Biological Activity: Endothall. (Unpublished study 

received Jul 9, 1975 under 1F1105; CDL: 094706-F) 

09-Jul1975 

114511 

Cope, O. (1965) Letter sent to E. Bowles dated Jul 23, 1965 Toxicity study of several 

Pennwalt herbicides against rainbow trout. (U.S. Fis h and Wildlife Service, Fish-Pesticide 

Research Laboratory; unpublished study; CDL:007441-K) 

15-Mar1966 

114513 

U.S. Fish and Wildlife Service, Fish Control Laboratory (19) Toxicity Study of Selected 

Test Chemicals on Rainbow Trout, Goldfish, Black Bullhead, and Bluegill. (Unpublished 

study; CDL:007441-M) 

15-Mar1966 

114514 

Walker, C. (1963) Letter sent to H. Lindaberry dated Apr 24, 1963 Toxicity study of 

selected pesticides on test animals. (U.S. Fish and Wildlife Service, Fish Control 

Laboratory; unpublished study; CDL:007441-N) 

15-Mar1966 

Howell, J. (1963) Letter sent to H. Lindaberry dated Jan 23, 1963 Toxicity of specific 

114515 Pennsalt chemicals to the sea lamprey and rainbow trout. (U.S. Fish and Wildlife Service, 

Bureau of Commercial Fisheries, Hammond Bay Biological Station; unpublished study; 

15-Mar1966 

CDL:007441-O) 

114516 

Zarbock, W. (1961) Letter sent to H. Lindaberry dated Oct 25, 1961 Toxicity test results 

for TD 191 on bluegills. (Ohio, Dept. of Natural Resources, Div. of Wildlife; unpublished 

study; CDL: 007441-P) 

15-Mar1966 

114517 

Bowles, E.; Keckemet, J.; Boyle, W.; et al. (1965) Hydrothol 191 as an Aquatic Herbicide 

in Flowing Water. (Unpublished study re- ceived Mar 15, 1966 under 4581-139; 

submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:007441-Q) 

15-Mar1966 

114529 Agchem (1975) Chemistry Data on Endothall. (Compilation; unpublished study received 

Feb 1, 1975 under 4581-EX-21; CDL: 094726-A) 

01-Feb1975 

114530 Agchem (1972) Efficacy of Endothall on Various Crops. (Compilation; unpublished study 

received May 4, 1972 under 4581-284; CDL:095336-B) 

04-May1972 

114535 

Pennwalt Corp. (1973) The Name, Chemical Identity, and Composition of the Pesticide 

Chemical: Endothall. (Compilation; unpublished study received Jun 27, 1973 under 

3F1416; CDL:095419-B) 

27-Jun1973 

114536 Keckemet, O. (1973) The Amount, Frequency, and Time of Application of the Pesticide 27-Jun142
Chemical: Endothall. (Unpublished study received Jun 27, 1973 under 3F1416; submitted 1973 

by Pennwalt Corp., Tacoma, WA; CDL:095419-C) 

114539 

Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Accelerate Cotton 

Harvest Aid. (Compilation; unpublished study received Apr 15, 1970 under 0F0972; 

CDL:095421-B) 

15-Apr1970 

114540 

Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the 

Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15, 

1970 under 0F0972; submitted by Pennwalt Corp., Tacoma, WA; CDL:095421-F) 

15-Apr1970 

114557 Agchem (1977) Residues of Endothal in Soil. (Compilation; un- published study received 

Oct 26, 1978 under 4581-282; CDL: 235432-C) 

26-Oct1978 

114558 Agchem (1975) Residues of Endothall in Water. (Compilation; unpublished study 

received Oct 26, 1978 under 4581-282; CDL: 235432-D) 

26-Oct1978 

Inglis, A.; Davis, E. (1972) Effects of Water Hardness on the Toxicity of Several Organic 

115756 and Inorganic Herbicides to Fish. By U.S. Fish and Wildlife Service, Fish-Pesticide 

Research Laboratory. Washington, DC: USFWS. (Technical papers of the Bureau of Sport 

21-Oct1982 

Fisheries and Wildlife 67; published study; CDL: 248614-P) 

115984 Pennsalt Chemicals Corp. (1967) Efficacy of Endothall and Other Chemicals on Potatoes. 

(Compilation; unpublished study received Jun 16, 1967 under 7G0608; CDL:090782-C) 

16-Jun1967 

116025 Pennwalt (1970) Endothal: Residues in Various Crops. (Compilation; unpublished study 

received on unknown date under 1F1105; CDL:090872-A) 

3M Co. (1970) Residue Analyses of 3MCAP-D and Other Chemicals in Various Products. 

116737 (Compilation; unpublished study received on unknown date under 10556-EX-1; 

CDL:127733-A) 

124667 

Agchem (1967) The Amount, Frequency, and Time of Application of the Pesticide 

Chemical: Accelerate Cotton Harvest Aid. (Compilation; unpublished study received Feb 

15, 1967 under 6G0503; CDL:094600-A) 

15-Feb1967 

128664 

Agchem (1975) Additional Data in Support of a Petition for Estab- lishment of a 

Temporary Negligible Tolerance for Endothall in or on Rice. (Compilation; unpublished 

study received Jun 1, 1983 under 45811-74; CDL:250413-A) 

01-Jun1983 

Becker, J.; Parke, G. (1977) The Acute Dermal LD50 of Des-I-Cate/ Accelerate (N.B. 77­

133023 99-6) on New Zealand Albino Rabbits: Laboratory No. 7E-5677. (Unpublished study 

received Dec 20, 1983 under 4581-206; prepared by Cannon Laboratories, Inc., submitted 

20-Dec1983 

by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:252010-D) 

Pierre, F.; Parke, G. (1977) A Primary Dermal Irritation Study of Des-I-Cate/Accelerate 

133024 

(N.B. 77-99-6) on Abraded and Non-abraded Skin of New Zealand Albino Rabbits: 

Laboratory No. 7E-5679. (Unpublished study received Dec 20, 1983 under 4581-206; prepared by Cannon Laboratories, Inc., submitted by Agchem Div., Pennwalt Corp., 

20-Dec1983 

Philadelphia, PA; CDL:252010-E) 

134936 Agchem (1966) Residues: Accelerate. (Compilation; unpublished study received 1966 

under 6G0503; CDL:092789-A) 

01-Jan1966 

147209 

Interregional Research Project No. 4 (1985) The Results of Tests on the Amo unt of 

Endothall Residues Remaining in or on Hops Including a Description of the Analytical 

Method Used. Unpublished compilation. 30 p. 

30-Apr1985 

147227 Interregional Research Project No. 4 (1984) Endothall on Hops: Efficacy and 

Phytotoxicity Data: PR No. 2381. Unpublished com- pilation. 9 p. 

30-Apr1985 

143
152170 Deenihan, M. (1984) Primary Eye Irritation of Hydrothol 191 NVP Report No. X4K065­

G. Unpublished study prepared by Northview Pacific Laboratories, Inc. 9 p. 

07-Feb1985 

42359700 

Atochem North America (1992) Submission of Data in Support of Endothall Acid 

(Technical) as Required in the Reregistration DCI: Toxicology Studies. Transmittal of 2 

studies. 

17-Jun1992 

42359701 

Pedersen, C.; Helsten, B. (1992) Endothall Technical: 21-Day Acute Oral LD50 Study in 

Mallard Ducks: Lab Project Number: 106-004-04. Unpublished study prepared by BioLife Associates, Ltd. 50 p. 

17-Jun1992 

42560900 Atochem North America, Inc. (1992) Submission of toxicity data in support of the data 

call-in for Endothall (Hydrothol 191). Transmittal of 1 study. 

19-Nov1992 

42560901 

Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Hydrothol 191 in the Rat: 

Final Report: Lab Project Number: 91-8356. Unpublished study prepared by 

Bio/dynamics, Inc. 126 p. 

19-Nov1992 

42629800 Elf Atochem N.A., Inc. (1993) Submission of product chemistry data in support of the 

data call-in for Endothall, Amine Salt. Transmittal of 1 study. 

21-Jan1993 

42629801 

Sweetapple, G. (1992) Amine Salt of Endothall Acid--Color, Physical State, Odor, 

Density, pH: Lab Project Number: 4200-92-0334-AS: 4200 -92-0334-AS-001. 

Unpublished study prepared by Ricerca, Inc. 43 p. 

21-Jan1993 

42670200 Elf Atochem N.A., Inc. (1993) Submission of environmental fate data in support of the 

Endothall (Amine Salt) data call-in. Transmittal of 1 study. 

18-Feb1993 

Wright, J. (1993) Terrestrial Field Dissipation Studies for Endothall (DES -I-CATE a 

42670201 Potato Vine Killer and a Harvest Aid for Alfalfa and Clover) Applied to Potatoes: Lab 

Project Number: WT-1-85: BR-92-54. Unpublished study prepared by Pennwalt Corp. 

18-Feb1993 

230 p. 

42694500 

Elf Atochem North America, Inc. (1993) Submission of Prior Efficacy Testing Data in 

Support of Experimental Use Permit for TD-2335 (Hydrothol 191). Transmittal of 1 

Study. 

17-Feb1993 

Krieg, D. et al. (1993) Compilation of Prior Efficacy Testing in Support of the 

42694501 Experimental Use Permit Application for TD-2335: Lab Project No. 2335. Unpublished 

study prepared by Roger Boren, Inc., S-L Agri-Development Corp. and D. Krieg Farm. 64 

17-Feb1993 

p. 

42774000 Elf Atochem North America Inc. (1993) Submission of toxicity data in support of the 

reregistration DCI for Endothall, Amine Salt. Transmittal of 3 studies. 

14-May1993 

42774001 

Mallory, V. (1993) Acute Exposure Oral Toxicity in Rats with Hydrothol 191 (Endothall): 

Lab Project Number: PH 402-ANA-002-92. Unpublished study prepared by Pharmakon 

Research International, Inc. 169 p. 

14-May1993 

42774002 

Mallory, V. (1993) Acute Exposure Dermal Toxicity with Hydrothol 191 (Endothall): Lab 

Project Number: PH 422-ANA-005-92. Unpublished study prepared by Pharmakon 

Research International, Inc. 78 p. 

14-May1993 

42774003 

Mallory, V. (1993) Primary Dermal Irritation study with Hydrothol 191 (Endothall): Lab 

Project Number: PH 420-ANA-002-92. Unpublished study prepared by Pharmakon 

Research International, Inc. 34 p. 

14-May1993 

42783200 Elf Atochem NA, Inc. (1993) Submission of product chemistry data to support the 

reregistration standard for Endothall. Transmittal of 1 study. 

24-May1993 

42783201 Wojcieck, B. (1993) Hydrothol 191 (Granular): Color, Physical State, Odor, Bulk 24-May144
Density, pH: Lab Project Number: 4200-92-0182-AS. Unpublished study prepared by 1993 

Ricerca, Inc. 22 p. 

42889100 Elf Atochem North America, Inc. (1993) Submission of product chemistry data in support 

of reregistration for endothall. Transmittal of 1 study. 

19-Aug1993 

42889101 

Wojcieck, B. (1993) Accelerate--Color, Physical State, Odor, Specific Gravity, pH, 

Viscosity: Lab Project Nu mber: 4200-92-0174-AS. Unpublished study prepared by 

Ricerca, Inc. 46 p. 

19-Aug1993 

43081300 Elf Atochem North America, Inc. (1993) Submittal of Product Chemistry Data in 

Response to DCI for Reregistration of Endothall Amine Salt. Transmittal of 1 study. 

11-Jan1994 

43081301 Gallacher, A. (1993) Amine Salt of Endothall Acid--Dissociation Constant: Lab Project 

Number: 4200-92-0323-AS. Unpublished study prepared by Ricerca, Inc. 63 p. 

11-Jan1994 

43082000 

Elf Atochem North America, Inc. (1993) Submittal of Corrosion Characteristics Data in 

Support of Reregistration of Endothall Amine Salt (Hydrothol 191 Aqueous, Hydrothol 

191 Granular, and Accelerate). Transmittal of 3 studies. 

11-Jan1994 

43082001 Sweetapple, G. (1993) Hydrothol 191, Aqueous--Corrosion Characteristics: Lab Project 

Number: 4200-92-0181-AS. Unpublished study prepared by Ricerca, Inc. 39 p. 

11-Jan1994 

43082002 Sweetapple, G. (1993) Hydrothol 191, Granular--Corrosion Characteristics: Lab Project 

Number: 4200-92-0183-AS. Unpublished study prepared by Ricerca, Inc. 35 p. 

11-Jan1994 

43082003 Sweetapple, G. (1993) Accelerate--Corrosion Characteristics: Lab Project Number: 4200-

92-0175-AS. Unpublished study prepared by Ricerca, Inc. 35 p. 

11-Jan1994 

43154800 Elf Atochem North America, Inc. (1993) Submission of toxicity data in support of 

reregistration for Endothall Amine Salts. Transmittal of 1 study. 

11-Jan1994 

43154801 

Stankowski, L. (1993) Ames/Salmonella Plate Incorporation Assay on Technical Endothal 

Amine Salt Solution: Lab Project Number: PH/301/ANA/001/92. Unpublished study 

prepared by Pharmakon Research International, Inc. 110 p. 

11-Jan1994 

43157400 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothal 

Amine Salt in Support of DCI Reregistration. Transmittal of 1 Study. 

15-Mar1994 

SanSebastian, J. (1994) In Vivo Micronucleus Test on Technical Endothal Amine Salt 

43157401 Solution in Mouse Bone Marrow Erythropoietic Cells: Lab Project Number: PH 309-

ANA-001-92. Unpublished study prepared by Pharmakon Research International, Inc. 73 

15-Mar1994 

p. 

43167900 

Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Hydrothol 191 

Aquatic Algicide and Herbicide in Support of Reregistration Data Call-In. Transmittal of 

2 studies. 

22-Mar1994 

43167901 

Pedersen, C.; Thompson, S. (1994) Hydrothol 191 Aquatic Algicide and Herbicide: 8-Day 

Acute Dietary LC50 Study in Bobwhite Quail: Lab Project Number: 106 -012-01: HWA 

153-148. Unpublished study prepared by Bio-Life Associates, Ltd. 100 p. 

22-Mar1994 

43167902 

Pedersen, C.; Thompson, S. (1994) Hydrothol 191 Aquatic Algicide and Herbicide: 8-Day 

Acute Dietary LC50 Study in Mallard Ducklings: Lab Project Number: 106-016-02: 

HWA 153-148. Unpublished study prepared by Bio-Life Associates, Ltd. 96 p. 

22-Mar1994 

43169200 

Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothall, 

Amine Salt (Hydrothol 191) in Support of a Data Call-In Reregistration. Transmittal of 1 

study. 

23-Mar1994 

43169201 Armondi, S. (1993) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with 23-Mar145
Hydrothol 191: Lab Project Number: PH 424-ANA-003-92: ALC-28C2-03. Unpublished 1994 

study prepared by Pharmakon Research International, Inc. 106 p. 

43196900 Elf Atochem North America, Inc. (1994) Submittal of Acute Aquatic Toxicity Data in 

Support of Reregistration of Endothall, Amine Salt. Transmittal of 3 studies. 

18-Apr1994 

43196901 

Bettencourt, M. (1994) Hydrothol 191--Acute Toxicity to Rainbow Trout (Oncorhynchus 

mykiss) Under Flow-Through Conditions: Final Report: Lab Project Number: 93 -8-4891: 

12442.0591.6138.108. Unpublished study prepared by Springborn Laboratories, Inc. 75 p. 

18-Apr1994 

43196902 

Putt, A. (1994) Hydrothol 191--Acute Toxicity to Daphnids (Daphnia magna) Under 

Flow-Through Conditions: Final Report: Lab Project Number: 93-9-4932: 

12442.0591.6139.115. Unpublished study prepared by Springborn Laboratories, Inc. 87 p. 

18-Apr1994 

Bettencourt, M. (1994) Hydrothol 191--Acute Toxicity to Sheepshead Minnow 

43196903 (Cyprinodon variegatus) Under Flow-Through Conditions: Final Report: Lab Project 

Number: 93-10-4980: 12442.0591.6140.505. Unpublished study prepared by Springborn 

18-Apr1994 

Laboratories, Inc. 70 p. 

43210000 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothall 

Amine Salt in Support of Reregistration Data Call-In. Transmittal of 1 study. 

02-May1994 

43210001 

Putt, A. (1994) Hydrothol 191--Acute Toxicity to Mysid Shrimp (Mysidopsis bahia) 

Under Flow-Through Conditions: Final Report: Lab Project Number: 93-10-5000: 

12442.0591.6141.515. Unpublished study prepared by Springborn Labs., Inc. 72 p. 

02-May1994 

43242300 

Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for 

ACCELERATE Harvest Aid for Cotton in Support of Re registration DCI. Transmittal of 

3 studies. 

24-May1994 

43242301 

Mallory, V. (1994) Acute Exposure Oral Toxicity with Accelerate: Lab Project Number: 

PH 402-ANA-003-93. Unpublished study prepared by Pharmakon Research International, 

Inc. 170 p. 

24-May1994 

43242302 

Mallory, V. (1994) Acute Exposure Dermal Toxicity with Accelerate: Lab Project 

Number: PH 422-ANA-005-93. Unpublished study prepared by Pharmakon Research 

International, Inc. 93 p. 

24-May1994 

43242303 

Mallory, V. (1994) Primary Dermal Irritation Study with Accelerate: Lab Project Number: 

PH 420-ANA-003-93: DAF-27H3-04. Unpublished study prepared by Pharmakon 

Research International, Inc. 39 p. 

24-May1994 

43265100 Elf Atochem North America, Inc. (1994) Submittal of Product Chemistry in Support of 

Reregistration of ENDOTHALL. Transmittal of 1 study. 

10-Jun1994 

43265101 

Malone, S. (1994) Amine Salt of Endothall TG (B46-48)--Stability: Lab Project Number: 

4200-92-0353-AS-001: 4200-92-0353-AS. Unpublished study prepared by Ricerca, Inc. 

57 p. 

10-Jun1994 

43276500 Elf Atochem North America, Inc. (1994) Submission of toxicology data in support of 

reregistration of Endothall Amine Salt. Transmittal of 1 study. 

21-Jun1994 

Bettencourt, M. (1994) Hydrothol 191: The Toxicity to Fathead Minnow (Pimephales 

43276501 promelas) During an Early Life -Stage Exposure: Final Report: Lab Project Number: 

94/1/5121: 12442/0692/6151/120. Unpublished study prepared by Springborn 

21-Jun1994 

Laboratories, Inc. 84 p. 

43299900 Elf Atochem North America, Inc. (1994) Submission of exposure assessment data in 

support of DCI for reregistration of endothall. Transmittal of 1 study. 

12-Jul1994 

43299901 Lunchick, C. (1994) Assessment of Worker Exposure and Margins of Exposure for 12-Jul146
Endothall Potassium and Amine Salt Formulation: Lab Project Number: EA070594. 1994 

Unpublished study prepared by Jellinek, Schwartz & Connolly, Inc. 82 p. 

43319600 Elf Atochem North America, Inc. (1994) Submission of product chemistry data in support 

of reregistration for Amine Salt of Endothall. Transmittal of 1 study. 

29-Jul1994 

43319601 

Lorence, P. (1994) Amine Salt of Endothall: Vapor Pressure: Lab Project Number: 

4200/92/0261/AS: 4200/92/0261/AS/001. Unpublished study prepared by Ricerca, Inc. 70 29-Jul1994 

p. 

43343500 Elf Atochem North America, Inc. (1994) Submission of toxicity data in support of 

reregistration for Endothall. Transmittal of 3 studies. 

22-Aug1994 

43343501 

Mallory, V. (1994) Comparative Acute Exposure Dermal Toxicity of Accelerate: Lab 

Project Number: PH/422/ANA/001/94. Unpublished study prepared by Pharmakon 

Research International, Inc. 229 p. 

22-Aug1994 

43343502 

Mallory, V. (1994) Comparative Primary Dermal Irritation Study of Accelerate: Lab 

Project Number: PH/420/ANA/001/94. Unpublished study prepared by Pharmakon 

Research International, Inc. 39 p. 

22-Aug1994 

43343503 

Margitich, D. (1994) 7 Day Repeat Dermal Toxicity Study in Rats Dose-Range-Finding: 

Amine Salt of Endothall: Lab Project Number: PH/442/ANA/001/93. Unpublished study 

prepared by Pharmakon Research International, Inc. 124 p. 

22-Aug1994 

43346600 Elf Atochem North America, Inc. (1994) Submission of Residue Data in Support of 

Endothall Reregistration. Transmittal of 1 Study. 

23-Aug1994 

43346601 

Sanger, T. (1994) Mono-(N,N-Dimethylalkylamine) Salt of (carbon 14)-Endothall: Nature 

of the Residue in Cotton: Final Report: Lab Project Number: HWI 6120-168: BR-93-48: 

R149301. Unpublished study prepared by Hazleton Wisconsin, Inc. 118 p. 

23-Aug1994 

43437800 Elf Atochem North America, Inc. (1994) Submittal of Gene Mutation Data in Support of 

Reregistration of ENDOTHALL, Amine Salt. Transmittal of 1 study. 

11-Jan1994 

43437801 

Stankowski, L. (1993) AS52/XPRT Mammalian Cell Forward Gene Mutation Assay on 

Technical Endothal Amine Salt Solution: Lab Project Number: PH 314-ANA -001-92. 

Unpublished study prepared by Pharmakon Research International, Inc. 144 p. 

11-Jan1994 

43437900 

Elf Atochem North America, Inc. (1994) Submission of Toxicity to Aquatic Organisms 

Data in Support of the Reregistration of the Amine Salt of Endothall. Transmittal of 1 

Study. 

07-Jun1994 

43437901 

Putt, A. (1994) Hydrothol 191--The Chronic Toxicity to Daphnia magna Under FlowThrough Conditions: Final Report: Lab Project Number: 93-11-5014: 

12442.0692.6150.130. Unpublished study prepared by Springborn Labs, Inc. 117 p. 

07-Jun1994 

43441500 Elf Atochem North America, Inc. (1994) Submission of Product Chemistry Data in 

Support of the Reregistration of Endothall and Salts Group. Transmittal of 2 Studies. 

04-Nov1994 

43441501 

Lorence, P. (1994) Amine Salt of Endothall--Octanol/Water Partition Coefficient: Lab 

Project Number: 4200-92-0260-AS: 4200-92-0260-AS-001. Unpublished study prepared 

by Ricerca, Inc. 53 p. 

04-Nov1994 

43441600 Wacker Silicones Corp. (1994) Submission of Product Chemistry and Toxicology Data in 

Support of Petition for (Inert Ingredient). Transmittal of 4 Studies. 

02-Sep1994 

43441601 Etter, S. (1994) (Inert Ingredient): Density Determination. Unpublished study prepared by 

Wacker-Chemie GmbH. 4 p. 

02-Sep1994 

43441602 Etter, S. (1994) (Inert Ingredient): Volatility. Unpublished study prepared by Wacker- 02-Sep147
Chemie GmbH. 11 p. 1994 

43441603 Etter, S. (1994) (Inert Ingredient): Refractive Index and Residual HCl. Unpublished study 

prepared by Wacker-Chemie GmbH. 7 p. 

02-Sep1994 

43441604 

Plotzke, K.; McMahon, J. (1993) Feasibility Study: In vitro Percutaneous Absorption of 

(carbon 14)-(Inert Ingredient) Fluid 350 cst in Male Rat Skin: Lab Project Number: 1993-

10000-38673. Unpublished study prepared by Dow Corning Corp. 13 p. 

02-Sep1994 

43465200 Elf Atochem North America, Inc. (1994) Submission of Toxicology Data in Support of 

Endothall Reregistration. Transmittal of 1 Study. 

22-Aug1994 

43465201 

Margitich, D.; Ackerman, L. (1994) 21 Day Dermal Toxicity Study in Rats: Amine Salt of 

Endothall: Lab Project Number: PH 430-ANA-001-93. Unpublished study prepared by 

Pharmakon Research International, Inc. 323 p. 

22-Aug1994 

43470100 Elf Atochem North America, Inc. (1994) Submission of Exposure Data in Support of 

Endothall Reregistration. Transmittal of 1 Study. 

02-Dec1994 

43470101 

Lunchick, C. (1994) Assessment of Swimmer Exposure to Endothall in Aquathol- and 

Hydrothol- Treated Bodies of Water. Unpublished study prepared by Jellinek, Schwartz, 

and Connolly, Inc. 11 p. 

02-Dec1994 

43472800 Elf Atochem North America, Inc. (1994) Submission of Toxicity and Product Chemistry 

Data in Support of the Reregistration of Endothall, Amine Salt. Transmittal of 3 Studies. 

06-Dec1994 

43472801 

Bettencourt, M. (1994) Hydrothol 191--Acute Toxicity to Bluegill Sunfish (Lepomis 

macrochirus) Under Flow-Through Conditions: Final Report: Lab Project Numbers: 94-4-

5253: 12442.0394.6169.105. Unpublished study prepared by Springborn Labs, Inc. 74 p. 

06-Dec1994 

43472802 Lorence, P. (1994) Amine Salt of Endothall--Solubility: Lab Project Numbers: 4200-92-

0259-AS: 4200-92-0259-AS-001. Unpublished study prepared by Ricerca, Inc. 68 p. 

06-Dec1994 

43480800 Elf Atochem North America, Inc. (1994) Submission of Toxicity Data in Support of 

Reregistration of Endothall, Amine Salt. Transmittal of 2 Studies. 

13-Dec1994 

43480801 

Trutter, J. (1994) 13-Week Subchronic Toxicity Study in Rats with Amine Salt of 

Endothall: Final Report: Lab Project Number: HWA 153-152. Unpublished study 

prepared by Hazleton Washington, Inc. 520 p. 

13-Dec1994 

43480802 

Trutter, J. (1994) 13-Week Subchronic Toxicity Study in Dogs with Amine Salt of 

Endothall: Final Report: Lab Project Number: HWA 153-153. Unpublished study 

prepared by Hazleton Washington, Inc. 376 p. 

13-Dec1994 

43550200 Elf Atochem North America, Inc. (1995) Submission of Hazard to Aquatic Organisms 

Data in Support of Endothall Reregistration. Transmittal of 1 Study. 

15-Feb1995 

Dionne, E. (1995) Hydrothol 191--Acute Neurotoxicity to Eastern Oyster (Crassostrea 

43550201 virginica) Under Flow-through Conditions: Final Report: Lab Project Number: 

12442.0591.6142.504: 93-8-4896. Unpublished study prepared by Springborn Labs, Inc. 

15-Feb1995 

108 p. 

43870400 Elf Atochem No rth America, Inc. (1995) Submission of Hazard to Non-Target Plants Data 

in Support of the Reregistration of Endothall and Salts. Transmittal of 1 Study. 

11-Dec1995 

Hoberg, J. (1995) Hydrothol 191--Determination of Effects on Seedling Emergence and 

43870401 Vegetative Vigor of Ten Plant Species: Final Report: Lab Project Number: 

12442.0195.6185.610: BR-94-20: 95-8-6045. Unpublished study prepared by Springborn 

11-Dec1995 

Labs, Inc. 339 p. 

43873900 Elf Atochem North America, Inc. (1995) Submission of Product Chemistry Data in 13-Dec148
Support of the Amended Registrations of Aquathol K Aquatic Herbicide and Hydrothol 1995 

191 Aquatic Algicide and Herbicide. Transmittal of 2 Studies. 

43873902 

Lincks, G. (1994) Hydrothol 1914 Aquatic Algicide and Herbicide Manufacturing 

Process: Lab Project Number: QC0007R0.QTR. Unpublished study prepared by Elf 

Atochem North America, Inc. 28 p. 

13-Dec1995 

43953100 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the 

Reregistration of Endothall and Salts. Transmittal of 1 Study. 

15-Mar1996 

43953101 

Guyton, B. (1996) Endothall: Magnitude of the Residue in Potato: Lab Project Number: 

BR-93-01: U:\ATOCHEM\ BR9301FR.DOC. Unpublished study prepared by McKenzie 

Laboratories, Inc. 315 p. 

15-Mar1996 

43954900 

Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in 

Support of the Registration of Amended Registration of Hydrothol 191 Granular Aquatic 

Algicide and Herbicide. Transmittal of 1 Study. 

18-Mar1996 

43954901 

Lincks, G.; Parker, J.; Wright, J. (1994) Hydrothol 191 Granular Aquatic Algicide and 

Herbicide: Manufacturing Process: Lab Project Number: QC0012R0.QTR: 

QC0003R3.PAM. Unpublished study prepared by Elf Atochem North America, Inc. 23 p. 

18-Mar1996 

43955000 

Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in 

Support of the Amended Registration of Accelerate: A Harvest Aid for Cotton. 

Transmittal of 1 Study. 

18-Mar1996 

43955001 

Lincks, G.; Parker, J.; Wright, J. (1994) Accelerate: A Harvest Aid for Cotton: 

Manufacturing Process: Lab Project Number: QC0009R0.QTR: QC0003R3.PAM. 

Unpublished study prepared by Elf Atochem North America, Inc. 28 p. 

18-Mar1996 

44012100 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the 

Reregistration of Endothall and Salts. Transmittal of 1 Study. 

15-May1996 

Ussary, J. (1996) Endothall: Magnitude of the Residue in Potato Processed Fractions: 

44012101 Final Report: Lab Project Number: BR-90-09: 52A-90: 52B-90. Unpublished study 

prepared by Elf Atochem North America, Inc.; Ussary Scientific Services; and McKenzie 

15-May1996 

Labs, Inc. 303 p. 

44037400 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the 

Reregistration of Endothall and Salts. Transmittal of 2 Studies. 

18-Jun1996 

Leppert, B. (1996) Endothall: Magnitude of the Residue in Cottonseed with Accelerate 

44037402 and a Pre-Emergent Use of TD-2335-2: Final Report: Lab Project Number: BR-93-05: 05­

93: 05A-93. Unpublished study prepare d by Elf Atochem North America, Inc. 276 p. 

18-Jun1996 

{Relates to letter L0000075}. 

44093400 Elf Atochem North America, Inc. (1996) Submission of Residue and Environmental Fate 

Data in Support of the Reregistration of Endothall and its Salts. Transmittal of 3 Studies. 

26-Aug1996 

Ussary, J. (1996) Endothall: Magnitude of the Residue in Cottonseed Processed Fractions 

44093401 

from Application of Accelerate, The Harvest Aid for Cotton, and TD2335-2, a Proposed 

Boll Opener Use: Final Report: Lab Project Number: BR-94-12: 94-12: 12A-94. 

Unpublished study prepared by South Texas Ag Research High Plains, Inc.; Texas A&M 

26-Aug1996 

University; and McKenzie Labs. 232 p. 

44103700 Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of 

Reregistration of Endothall & Salts. Transmittal of 1 Study. 

06-Sep1996 

44103701 Carr, B. (1996) Residue of Endothall in Alfalfa Seed Following Application of Des-i-cate 

and Hydrothol 191 to Alfalfa Seed Crop: Lab Project Number: BR-93-08: 08-93: PRM06-Sep1996 

149
047. Unpublished study prepared by Elf Atochem North America, Inc. and McKenzie 

Laboratories. 219 p. 

44127800 Elf Atochem North America, Inc. (1996) Submission of Toxicity Data in Support of the 

Reregistration of Endothall, Amine Salt. Transmittal of 6 Studies. 

03-Oct1996 

44127801 

Hoberg, J. (1993) Hydrothol 191--Determination of Effects on Seed Germination of Ten 

Plant Species: Summary Report: Lab Project Number: 93-9-4942: 12442.0593.6159.610: 

050892. Unpublished study prepared by Springborn Labs., Inc. 56 p. 

03-Oct1996 

44127802 

Hoberg, J. (1994) Hydrothol 191--Toxicity to the Marine Diatom, Skeletonema costatum: 

Summary Report: Lab Project Number: 93-11-5025: 12442.0593.6162.450: 040692. 

Unpublished study prepared by Springborn Labs., Inc. 33 p. 

03-Oct1996 

44127803 

Hoberg, J. (1994) Hydrothol 191--Toxicity to the Freshwater Alga, Anabaena flosaquae: 

Summary Report: Lab Project Number: 93-11-5023: 12442.0593.6163.420: 040692. 

Unpublished study prepared by Springborn Labs., Inc. 36 p. 

03-Oct1996 

Hoberg, J. (1994) Hydrothol 191--Toxicity to the Freshwater Alga, Selenastrum 

44127804 capricornutum: Summary Report: Lab Project Number: 93-11-5022: 

12442.0593.6160.430: 040692. Unpublished study prepared by Springborn Labs., Inc. 33 

03-Oct1996 

p. 

44127805 

Hoberg, J. (1994) Hydrothol 191--Toxicity to the Freshwater Diatom, Navicula 

pelliculosa: Summary Report: Lab Project Number: 93-11-5021: 12442.0593.6161.440: 

040692. Unpublished study prepared by Springborn Labs., Inc. 33 p. 

03-Oct1996 

44127806 

Hoberg, J. (1994) Hydrothol 191--Toxicity to Duckweed, Lemna gibba: Summary Report: 

Lab Project Number: 93-11-5024: 12442. 0593.6164.410: 040692. Unpublished study 

prepared by Springborn Labs., Inc. 32 p. 

03-Oct1996 

44263500 Elf Atochem North America, Inc. (1997) Submission of Metabolism and Residue Data in 

Support of the Reregistration of Endothall and Salts. Transmittal of 8 Studies. 

29-Apr1997 

Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44263506 Treatment of Celery with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR-91-02: 70-91: 

29-Apr1997 

70A-91. Unpublished study prepared by McKenzie Labs, Inc. 237 p. 

Toth, J.; Antle, P. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44263507 Treatment of Grapefruit with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: (Final Report): Lab Project Number: BR-91-04: 74-91: 74A29-Apr1997 

91. Unpublished study prepared by McKenzie Labs, Inc. 224 p. 

Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44263508 Treatment of Peppers with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR-91-05: 73-91: 

29-Apr1997 

73A-91. Unpublished study prepared by McKenzie Labs, Inc. 223 p. 

44320400 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of 

Petition for Tolerance for Endothall on Apples. Transmittal of 3 Studies. 

03-Jul1997 

44320403 Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number: 

FQPA 697E. Unpublished study prepared by Elf Atochem N.A., Inc. 42 p. 

03-Jul1997 

44322000 

Elf Atochem North America, Inc. (1997) Submission of Residue, Toxicity and Exposure 

Data in Support of the Petition for Tolerance of Endothall on Cotton. Transmittal of 2 

Studies. 

01-Jul1997 

44322001 Ussary, J. (1997) Endothall: Magnitude of the Residue in Cottonseed and Gin By- 01-Jul150
Products After Application of Accelerate, the Harvest Aid for Cotton, and TD-2335-02, a 1997 

Proposed Boll Opener Product: Final Report: Lab Project Number: BR-94-09: 09-94: 

09G-94. Unpublished study prepared by Ussary Scientific Services and McKenzie Labs. 

415 p. 

44322002 Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number: 

FQPA 697E. Unpublished study prepared by Elf Atochem North America, Inc. 42 p. 

01-Jul1997 

44334300 Elf Atochem N.A., Inc. (1997) Submission of Residue Data in Support of the 

Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 

25-Jul1997 

Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44334301 

Treatment of Cabbage with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: Final Report: Lab Project Number: BR-91-01: 71A-91: 71B91. Unpublished study prepared by Elf Atochem N.A., Inc. and McKenzie Labs, Inc. 241 

25-Jul1997 

p. 

44343100 Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of the 

Reregistration for Endothall Acid & Salts. Transmittal of 1 Study. 

06-Aug1997 

Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops: 

44343101 Treatment of Turnips with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 

Hydrothol 191 Herbicides: Lab Project Number: BR-91-06: 72A-91: 72B-91. 

06-Aug1997 

Unpublished study prepared by McKenzie Laboratories, Inc. 237 p. 

44578400 Elf Atochem North America, Inc. (1998) Submission of Environmental Fate Data in 

Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study. 

11-Jun1998 

44578401 

Mao, J. (1997) Endothall Amine Salt--Determination of pH Dependent Hydrolysis: Lab 

Project Number: 12442.0396.6209.715: KP-96-01: 96-6-6537. Unpublished study 

prepared by Springborn laboratories, Inc. 79 p. 

11-Jun1998 

44608600 Elf Atochem North America, Inc. (1998) Submission of Residue Chemistry Data in 

Support of the Reregistration of Endothall Acids and Salts. Transmittal of 1 Study. 

16-Jul1998 

44608601 

Fomenko, J. (1998) Evaluation of Endothall Through the FDA Multiresidue Methods: Lab 

Project Number: A036.50: KP-97-18. Unpublished study prepared by Maxim 

Technologies, Inc. 63 p. {OPPTS 860.1360} 

16-Jul1998 

44700400 Elf Atochem North America, Inc. (1998) Submission of Toxicity Data in Support of the 

FIFRA 6(a)(2) Requirement for Hydrothol 191. Transmittal of 1 Study. 

18-Nov1998 

Serdar, D.; Johnson, A.; Stinson, M. (1995) Seawater Challenge of Chinook Salmon 

44700401 Smolts (Onchorynchus tshawytscha) Exposed to the Aquatic Herbicide Hydrothol 191: 

Lab Project Number: 95-358. Unpublished study prepared by Washington State 

18-Nov1998 

Department of Ecology. 30 p. 

44820100 

Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, Risk 

Assessment and Exposure Data in Support of the Reregistration of Endothall Acid and 

Salts. Transmittal of 4 Studies. 

05-May1999 

Keckemet, O.; Sharp, J. (1999) Historical Aquatic Residue and Dissipation Data for 

44820101 Endothall Aquatic Products Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic 

Algicide and Herbicide: Lab Project Number: KP -99-02: WT-86-C-11. Unpublished study 

05-May1999 

prepared by Elf Atochem. 316 p. {OPPTS 860.1400} 

Dionne, E.; Sharp, J.; Formella, T. (1999) Dipotassium Salt of Endothall: A Freshwater 

44820102 Fish and Shellfish Magnitude of Residues Study in a Static Aquatic System: Lab Project 

Number: KP-97-14: 52897/171.4/FIFRA: EN1115.95. Unpublished study prepared by Elf 

05-May1999 

Atochem and ABC Laboratories, Inc. 213 p. {OPPTS 860.1400} 

151
44820103 

Biever, R. (1998) Hydrothol 191: An Aquatic Dissipation Study for Aquatic Non-Crop 

Uses: Final Report: Lab Project Number: KP-96-14: 98-1-7215: 12442-0896-6214-330. 

Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 164 p. 

05-May1999 

44820104 

Giddings, J. (1999) Ecological Risk Assessment of Aquatic Herbicides Containing 

Endothall: Final Report: Lab Project Number: KP-98-31: 98-11-7564: 12442-0898-6271-

251. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 64 p. 

05-May1999 

44828800 

Elf Atochem North America (1999) Submission of Environmental Fate Data in Support of 

the Reregistration of Endothall Acid and Salts Containing Products Aquathol K and 

Hydrothal 191. Transmittal of 2 Studies. 

05-May1999 

Singh, P.; Ritter, A.; Sharp, J. et al. (1999) Aquatic Dissipation Modeling of Endothall 

44828801 Acid: Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide: 

Lab Project Number: ATO KP-97-16: WEI 286.01. Unpublished study prepared by 

05-May1999 

Waterborne Environmental, Inc. 363 p. 

Williams, W.; Ritter, A.; Sharp, J. et al. (1999) An Evaluation of the Aquatic Dissipation 

44828802 of Endothall Aquatic Product: Aquathol, K Aquatic Herbicide and Hydrothol 191 Aquatic 

Algicide and Herbicide: Lab Project Number: ATOKP-98-32: WEI-286.06. Unpublished 

05-May1999 

study prepared by Waterborne Environmental, Inc. 69 p. 

44976700 

Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the 

Reregistration of Endothall Acids and Salts Containing Product Hydrothol 191. 

Transmittal of 1 Study. 

20-Oct1999 

Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191: A 96-Hour Toxicity Test with 

44976701 the Marine Diatom (Skeletonema costatum): Final Report: Lab Project Number: 299A104. Unpublished study prepared by Wildlife International , Ltd. 38 p. {OPPTS 

20-Oct1999 

850.5400} 

45039500 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in 

Support of the Reregistration of Endothall and Endothall Salts. Transmittal of 1 Study. 

28-Jan2000 

45039501 

Toth, J. (1999) Immunochemical Method for Residues of Endothall in Water: Lab Project 

Number: KP-023-00. Unpublished study prepared by Elf Atochem North America, Inc. 74 

p. {OPPTS 850.7100} 

28-Jan2000 

45146300 Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in 

Support of the Reregistration of Endothall Acid and its Salts. Transmittal of 2 Studies. 

19-Jun2000 

45146301 

Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potatoes: 

Final Report: Lab Project Number: KP-98-22: 22A-98: 22B-98. Unpublished study 

prepared by Elf Atochem North America, Inc. 202 p. {OPPTS 860.1500} 

19-Jun2000 

Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potato 

45146302 Processing Fractions: Final Report: Lab Project Number: KP-98-23: 44884: 23A-98. 

Unpublished study prepared by Elf Atochem North America, Inc. 162 p. {OPPTS 

19-Jun2000 

860.1520} 

45764300 Cerexagri, Inc. (2002) Submission of Risk and Exposure Assessment Data in Support of 

the Registration of Endothall Aquatic Herbicides. Transmittal of 1 Study. 

25-Sep2002 

45764301 

Davis, C.; Ampofo, S. (2002) Exposure and Risk Assessment for Persons Reentering 

Non-Food Areas Treated with Endothall Aquatic Herbicides via Irrigation Water. 

Unpublished study prepared by Cerexagri, Inc. 26 p. 

25-Sep2002 

92061000 Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Mono(N,Ndimethyl alkyl* amine) endothall (7-ocabicyclo(2. 2. 

25-May1990 

152
92061001 

Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

00035237. Hydrothol 191-Acute Oral LD50 Test-Bobwhite Quail: Project No. 110-115.: 

11 p. 

25-May1990 

92061002 

Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID 

00035240. Eight-day Dietary LC50 of Hydrothol 191 to Bobwhite Quail: Project No. 110­

112.: 12 p. 

25-May1990 

92061999 

Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Mono(N,Ndimethyl alkyl amine) endothall (7-ocabicyclo(2. 2. Correspondence and Supporting 

Material. 

25-May1990 

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E. Generic Data Call-In 

Note that the complete Data Call-In (DCI), with all pertinent instructions, will be 

sent to registrants under separate cover. 

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F. Product Specific Data Call-In 

Note that the complete Data Call-In (DCI), with all pertinent instructions, will be 

sent to registrants under separate cover. 

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G. EPA's Batching of Endothall Products for Meeting Acute Toxicity Data 

Require ments for Reregistration 

In an effort to reduce the time, resources and number of animals needed to fulfill 

the acute toxicity data requirements for reregistration of products containing Endothall as 

the active ingredient, the Agency has batched products which can be considered similar 

for purposes of acute toxicity. Factors considered in the sorting process include each 

product's active and inert ingredients (identity, percent composition and biological 

activity), type of formulation (e.g., emulsifiable concentrate, aerosol, wettable powder, 

granular, etc.), and labeling (e.g., signal word, use classification, precautionary labeling, 

etc.). Note that the Agency is not describing batched products as "substantially similar" 

since some products within a batch may not be considered chemically similar or have 

identical use patterns. 

Using available information, batching has been accomplished by the process 

described in the preceding paragraph. Notwith-standing the batching process, the Agency 

reserves the right to require, at any time, acute toxicity data for an individual product 

should the need arise. 

Registrants of products within a batch may choose to cooperatively generate, 

submit or cite a single battery of six acute toxicological studies to represent all the 

products within that batch. It is the registrants' option to participate in the process with all 

other registrants, only some of the other registrants, or only their own products within a 

batch, or to generate all the required acute toxicological studies for each of their own 

products. If a registrant chooses to generate the data for a batch, he/she must use one of 

the products within the batch as the test material. If a registrant chooses to rely upon 

previously submitted acute toxicity data, he/she may do so provided that the data base is 

complete and valid by today's standards (see acceptance criteria attached), the 

formulation tested is considered by EPA to be similar for acute toxicity, and the 

formulation has not been significantly altered since submission and acceptance of the 

acute toxicity data. Regardless of whether new data is generated or existing data is 

referenced, registrants must clearly identify the test material by EPA Registration 

Number. If more than one confidential statement of formula (CSF) exists for a product, 

the registrant must indicate the formulation actually tested by identifying the 

corresponding CSF. 

In deciding how to meet the product specific data requirements, registrants must 

follow the directions given in the Data Call-In Notice and its attachments appended to the 

RED. The DCI Notice contains two response forms which are to be completed and 

submitted to the Agency within 90 days of receipt. The first form, "Data Call-In 

Response," asks whether the registrant will meet the data requirements for each product. 

The second form, "Requirements Status and Registrant's Response," lists the product 

specific data required for each product, including the standard six acute toxicity tests. A 

registrant who wishes to participate in a batch must decide whether he/she will provide 

the data or depend on someone else to do so. If a registrant supplies the data to support a 

batch of products, he/she must select one of the following options: Developing Data 

204
(Option 1), Submitting an Existing Study (Option 4), Upgrading an Existing Study 

(Option 5) or Citing an Existing Study (Option 6). If a registrant depends on another's 

data, he/she must choose among: Cost Sharing (Option 2), Offers to Cost Share (Option 

3) or Citing an Existing Study (Option 6). If a registrant does not want to participate in a 

batch, the choices are Options 1, 4, 5 or 6. However, a registrant should know that 

choosing not to participate in a batch does not preclude other registrants in the batch from 

citing his/her studies and offering to cost share (Option 3) those studies. 

Ten products were found which contain Endothall as the active ingredient. These 

products have been placed into two batches and a no batch group in accordance with the 

active and inert ingredients and type of formulation. 

Batching Instructions: 

No Batch: Each product in this Batch should generate their own data. EPA Reg. No. 

4581-204 may rely on acute data used to support batch 2. 

NOTE: The technical acute toxicity values included in this document are for 

informational purposes only. The data supporting these values may or may not meet the 

current acceptance criteria. 

Batch # EPA Reg. No. Percent Active Ingredient 

1 4581-172 11.2 

4581-201 10.1 

2 1448-352 53.0 

4581-174 53.0 

4581-380 53.0 

4581-381 53.0 

No Batch 4581-204 40.3 

4581-257 75 

4581-284 15.9 

4581-388 63.0 

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H. List of Registrants Sent Data Call-Ins 

Technical Registrants Sent Generic Data Call-In: 

1. Cerexagri, Inc.

End-Use Registrants Sent Product Data Call-In

1. Cerexagri, Inc. 

2. Buckman Laboratory, Inc.

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I. List of Available Related Documents and Electronically Available Forms

Pesticide Registration Forms are available at the following EPA internet site: 

http://www.epa.gov/opprd001/forms 

Pesticide Registration Forms (these forms are in PDF format and require the 

Acrobat reader) 

Instructions 

1. Print our and complete the forms. (Note: Form numbers that are bolded 

can be filled out on your computer than printed.) 

2. The completed form(s) should be submitted in hardcopy in accord with the 

existing policy. 

3. Mail the forms, along with any additional documents necessary to comply 

with EPA regulations covering your request, to the address below or the 

Document Processing Desk. 

DO NOT fax or e-mail any form containing 'Confidential Business 

Information' or 'Sensitive Information'. 

If you have any problems accessing these forms, please contact Nicole 

Williams at (703) 308-5551 or by email at williams.nicole@epa.gov 

The following Agency Pesticide Registration Forms are currently available via the 

internet at the following locations: 

8570-1 Application for Pesticide Registration/Amendment http://www.epa.gov/opprd001/forms/8570-1.pdf 

8570-4 Confidential Statement of Formula http://www.epa.gov/opprd001/forms/8570-4.pdf 

8570-5 Notice of Supplemental Registration of Distribution of 

a Registered Pesticide Product 

http://www.epa.gov/opprd001/forms/8570-5.pdf 

8570-17 Application for an Experimental Use Permit http://www.epa.gov/opprd001/forms/8570-17.pdf 

8570-25 Application for/Notification of State Registration of a 

Pesticide To Meet a Special Local Need 

http://www.epa.gov/opprd001/forms/8570-25.pdf 

8570-27 Formulator’s Exemption Statement http://www.epa.gov/opprd001/forms/8570-27.pdf 

8570-28 Certification of Compliance with Data Gap Procedures http://www.epa.gov/opprd001/forms/8570-28.pdf 

8570-30 Pesticide Registration Maintenance Fee Filing http://www.epa.gov/opprd001/forms/8570-30.pdf 

8570-32 Certification of Attempt to Enter into an Agreement 

with other Registrants for Development of Data 

http://www.epa.gov/opprd001/forms/8570-32.pdf 

8570-34 Certification with Respect to Citations of Data (in PR 

Notice 98-5) 

http://www.epa.gov/opppmsd1/PR_Notices/pr98-

5.pdf 

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8570-35 Data Matrix (in PR Notice 98-5) http://www.epa.gov/opppmsd1/PR_Notices/pr98-

5.pdf 

8570-36 Summary of the Physical/Chemical Properties (in PR http://www.epa.gov/opppmsd1/PR_Notices/pr98-

Notice 98 -1) 1.pdf 

8570-37 Self-Certification Statement for the Physical/Chemical http://www.epa.gov/opppms d1/PR_Notices/pr98-

Properties (in PR Notice 98-1) 1.pdf 

Pesticide Registration Kit: www.epa.gov/pesticides/registrationkit/. 

Dear Registrant: 

For your convenience, we have assembled an online registration kit that contains 

the following pertinent forms and information needed to register a pesticide product with 

the U.S. Environmental Protection Agency’s Office of Pesticide Programs (OPP): 

1. The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the 

Federal Food, Drug and Cosmetic Act (FFDCA) as Amended by the Food 

Quality Protection Act (FQPA) of 1996. 

2. Pesticide Registration (PR) Notices 

a. 83-3 Label Improvement Program—Storage and Disposal 

Statements 

b. 84-1 Clarification of Label Improvement Program 

c. 86-5 Standard Format for Data Submitted under FIFRA 

d. 87-1 Label Improvement Program for Pesticides Applied through 

Irrigation Systems (Chemigation) 

e. 87-6 Inert Ingredients in Pesticide Products Policy Statement 

f. 90-1 Inert Ingredients in Pesticide Products; Revised Policy 

Statement 

g. 95-2 Notifications, Non-notifications, and Minor Formulation 

Amendments 

h. 98-1 Self Certification of Product Chemistry Data with 

Attachments (This document is in PDF format and requires the

Acrobat reader.) 

Other PR Notices can be found at http://www.epa.gov/opppmsd1/PR_Notices. 

3. Pesticide Product Registration Application Forms (These forms are in 

PDF format and will require the Acrobat reader.) 

a. EPA Form No. 8570-1, Application for Pesticide 

Registration/Amendment 

b. EPA Form No. 8570-4, Confidential Statement of Formula 

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c. EPA Form No. 8570-27, Formulator’s Exemption Statement 

d. EPA Form No. 8570-34, Certification with Respect to Citations of 

Data 

e. EPA Form No. 8570-35, Data Matrix 

4. General Pesticide Information (Some of these forms are in PDF format 

and will require the Acrobat reader.) 

a. Registration Division Personnel Contact List 

b. Biopestic ides and Pollution Prevention Division (BPPD) Contacts 

c. Antimicrobials Division Organizational Structure/Contact List 

d. 53 F.R. 15952, Pesticide Registration Procedures; Pesticide Data

Requirements (PDF format) 

e. 40 CFR Part 156, Labeling Requirements for Pesticides and 

Devices (PDF format) 

f. 40 CFR Part 158, Data Requirements for Registration (PDF

format) 

g. 50 F.R. 48833, Disclosure of Reviews of Pesticide Data 

(November 27, 1985) 

Before submitting your application for registration, you may wish to consult some 

additional sources of information. These include: 

1. The Office of Pesticide Programs’ Web Site 

2. The booklet “General Information on Applying for Registration of 

Pesticides in the United States”, PB92-221811, available through the 

National Technical Information Service (NTIS) at the following address: 

National Technical Information Service (NTIS)

5285 Port Royal Road

Springfield, VA 22161 

The telephone number for NTIS is (703) 605-6000. Please note that EPA is 

currently in the process of updating this booklet to reflect the changes in the registration 

program resulting from the passage of the FQPA and the reorganization of the Office of 

Pesticide Programs. We anticipate that this publication will become available during the 

Fall of 1998. 

3. The National Pesticide Information Retrieval System (NPIRS) of Purdue 

University’s Center for Environmental and Regulatory Information 

Systems. This service does charge a fee for subscriptions and custom 

searches. You can contact NPIRS by telephone at (765) 494-6614 or 

through their Web site. 

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4. The National Pesticide Telecommunications Network (NPTN) can provide 

information on active ingredients, uses, toxicology, and chemistry of 

pesticides. You can contact NPTN by telephone at (800) 858-7378 or 

through their Web site: ace.orst.edu/info/nptn. 

The Agency will return a notice of receipt of an application for registration or 

amended registration, experimental use permit, or amendment to a petition if the 

applicant or petitioner encloses with his submission a stamped, self-addressed postcard. 

The postcard must contain the following entries to be completed by OPP: 

Date of receipt 

EPA identifying number 

Product Manager Assignment 

Other identifying information may be included by the applicant to link the 

acknowledgment of receipt to the specific application submitted. EPA will stamp the date 

of receipt and provide the EPA identifying File Symbol or petition number for the new 

submission. The identifying number should be used whenever you contact the Agency 

concerning an application for registration, experimental use permit, or tolerance petition. 

To assist us in ensuring that all data you have submitted for the chemical are properly 

coded and assigned to your company, please include a list of all synonyms, common and 

trade names, company experimental codes, and other names which identify the chemical 

(including “blind” codes used when a sample was submitted for testing by commercial or 

academic facilities). Please provide a CAS number if one has been assigned. 

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