**CONTRACT      TO SUPPLY ACTIVE INGREDIENTS**

| § | **SIRTON                PHARMACEUTICALS S.p.A**                ,                whose registered office is in Villa Guardia (CO), Piazza XX Settembre                nr.                2, Tax Code 01192270138, represented by dr. Laura Iris Ferro, Deputy                Chairwoman (hereinafter referred to as **SIRTON**) |
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**AND**

| § | **GENTIUM                S.p.A.** **,**                whose registered office is in Villa Guardia (CO), Piazza XX Settembre                nr.                2. Tax Code 02098100130, represented by dr. Salvatore Calabrese,                Director                of Administration (hereinafter referred to as **GENTIUM**); |
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**WHEREAS:**

| § | **GENTIUM**produces                and sells active ingredients for pharmaceutical use and raw materials                for                pharmaceutical use; |
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| § | **SIRTON**                uses said active ingredients to produce specialty pharmaceutical                products |
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**NOW,      THEREFORE, THE PARTIES AGREE AS FOLLOWS: **

| 1. | **GENTIUM**undertakes                to supply SIRTON with its active ingredients on the basis of standard                purchase orders issued by SIRTON; |
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| 2. | **SIRTON**undertakes                to provide GENTIUM with purchase orders three months before the date                envisaged for the supply of such as well as purchase forecasts for                rolling                12 month periods on the basis of which GENTIUM may plan its production                activities; |
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| 3. | The                sale price of each active ingredient will be established as indicated                in                attachment “A” to this contract. |
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| 4. | **SIRTON**                undertakes to pay the agreed amounts on submission of standard invoices                and will pay via direct bank transfer 60 days from the end of the                month in                which the invoice is dated. |
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| 5 | The                contract will be effective as of 02/01/2006 and will expire on 31/12/2006                and will be considered tacitly renewed from year to year unless one                of the                parties gives notice to the other, sent at least one month prior                to                expiry. |
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| 4. | The                Parties reserve the right to revise the contractual conditions on                expiry                or during the life of the contract if there are any significant changes                to                the services rendered or the cost of such. |
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| 5. | The                Parties acknowledge, with immediate effect, the right to negotiate                variations of the fees established above on the basis of the actual                amount                of services rendered. |
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| 6. | All                correspondence regarding this Contract must be made in writing and                sent by                hand, by fax, telegram or registered mail with return receipt to                the                registered office of each Party. |
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| 7. | Any                dispute regarding this Contract will be settled by a Board of Arbitration;                each of the Parties will nominate its own arbitrator, who in turn                will                choose the third member of the Board of Arbitration, who will act                as                Chairman of said Board. |
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| 8. | This                Contract cancels and replaces all previous service provision agreements                between the Parties and may not be amended or changed in any way                with the                exception of that expressly provided for herein or with the written                agreement of the Parties signed by their authorised                representatives. |
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| /s/ Laura              Iris Ferro                                                          |   |   | /s/ Salvatore              Calabrese                                                |
| **Sirton              Pharmaceuticals S.p.A**                                                   |   |   | **Gentium              S.p.A.**                                                                    |
| Deputy                Chairwoman    *(dr.                Laura Iris Ferro)* |   |   | Director                of                Administration*(dr. Salvatore                Calabrese)* |

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