|**Identifiable Intangible Assets and Goodwill (Tables)**                               | 12 Months Ended                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
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|**Goodwill and Intangible Assets Disclosure [Abstract]**                               |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Schedule of Finite-Lived Intangible Assets                                             | The following summarizes the components ofIdentifiable intangible assets:As of December 31, 2021As of December 31, 2020(MILLIONS)GrossCarryingAmountAccumulatedAmortizationIdentifiableIntangibleAssets, lessAccumulatedAmortizationGrossCarryingAmountAccumulatedAmortizationIdentifiableIntangibleAssets, lessAccumulatedAmortizationFinite-lived intangible assetsDeveloped technology rights(a)$73,346$(53,732)$19,614$73,040$(50,532)$22,508Brands922(807)115922(774)148Licensing agreements and other2,284(1,299)9852,292(1,187)1,10676,552(55,838)20,71476,255(52,493)23,762Indefinite-lived intangible assetsBrands827827827827IPR&D3,0923,0923,1753,175Licensing agreements and other5135135735734,4324,4324,5754,575Identifiable intangible assets(b)$80,984$(55,838)$25,146$80,830$(52,493)$28,337(a)The increase in the gross carrying amount primarily reflects $500 million of capitalized Comirnaty sales milestones to BioNTech, partially offset by net losses from foreign currency translation adjustments.(b)The decrease is primarily due to amortization, partially offset by the capitalization of the Comirnaty milestones described above.
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|The following summarizes the components ofIdentifiable intangible assets:             
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|(MILLIONS)                                                                             |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Finite-lived intangible assets                                                         |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Developed technology rights(a)                                                         |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Brands                                                                                 |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Licensing agreements and other                                                         |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
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|Indefinite-lived intangible assets                                                     |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Brands                                                                                 |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|IPR&D                                                                                  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
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|Licensing agreements and other                                                         |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|                                                                                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Identifiable intangible assets(b)                                                      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Schedule of Indefinite-Lived Intangible Assets                                         | The following summarizes the components ofIdentifiable intangible assets:As of December 31, 2021As of December 31, 2020(MILLIONS)GrossCarryingAmountAccumulatedAmortizationIdentifiableIntangibleAssets, lessAccumulatedAmortizationGrossCarryingAmountAccumulatedAmortizationIdentifiableIntangibleAssets, lessAccumulatedAmortizationFinite-lived intangible assetsDeveloped technology rights(a)$73,346$(53,732)$19,614$73,040$(50,532)$22,508Brands922(807)115922(774)148Licensing agreements and other2,284(1,299)9852,292(1,187)1,10676,552(55,838)20,71476,255(52,493)23,762Indefinite-lived intangible assetsBrands827827827827IPR&D3,0923,0923,1753,175Licensing agreements and other5135135735734,4324,4324,5754,575Identifiable intangible assets(b)$80,984$(55,838)$25,146$80,830$(52,493)$28,337(a)The increase in the gross carrying amount primarily reflects $500 million of capitalized Comirnaty sales milestones to BioNTech, partially offset by net losses from foreign currency translation adjustments.(b)The decrease is primarily due to amortization, partially offset by the capitalization of the Comirnaty milestones described above.
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|The following summarizes the components ofIdentifiable intangible assets:             
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|(MILLIONS)                                                                             |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Finite-lived intangible assets                                                         |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Developed technology rights(a)                                                         |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Brands                                                                                 |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Licensing agreements and other                                                         |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
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|Indefinite-lived intangible assets                                                     |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Brands                                                                                 |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|IPR&D                                                                                  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
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|Licensing agreements and other                                                         |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
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|Identifiable intangible assets(b)                                                      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Schedule of Expected Amortization Expense                                              | The following provides the expected annual amortization expense:(MILLIONS)20222023202420252026Amortization expense$3,279$2,936$2,686$2,500$2,449                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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|The following provides the expected annual amortization expense:                      
|(MILLIONS)                                                                             |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Amortization expense                                                                   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Schedule of Goodwill                                                                   | The following summarizes the components and changes in the carrying amount ofGoodwill:(MILLIONS)Total(a)Balance, January 1, 2020$48,181Additions(b)727Other(c)648Balance, December 31, 202049,556Additions—Other(c)(348)Balance, December 31, 2021$49,208(a)As a result of the reorganization of our commercial operations during the fourth quarter of 2021 (seeNote 17), we were required to estimate the relative fair values of our PC1 and Hospital organizations to determine any reallocation of goodwill. We completed this analysis and determined that no goodwill was required to be reallocated. As a result, our entire goodwill balance continues to be assigned within the Biopharma reportable segment.(b)Additions primarily represent the impact of measurement period adjustments related to our Array acquisition (seeNote 2A).(c)Other represents the impact of foreign exchange.                                                                                                                                                                                                                                                             
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|The following summarizes the components and changes in the carrying amount ofGoodwill:
|(MILLIONS)                                                                             |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Balance, January 1, 2020                                                               |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Additions(b)                                                                           |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Other(c)                                                                               |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Balance, December 31, 2020                                                             |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Additions                                                                              |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Other(c)                                                                               |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|Balance, December 31, 2021                                                             |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    

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