**Exhibit 10.47**

**Amendment to License Agreement**

This will amend the license agreement between MicroTherapeutics, Inc. (“MTI”) and Biocoat, Inc. (“Biocoat”) of December 9, 1999(the “Agreement” and this “Amendment”).

The effective date ofthis Amendment is January 1, 2005.

Schedule A of theAgreement, listing the Products, is hereby replaced with the attached ScheduleA, dated November 4, 2004.

MTI hereby representsthat it intends to use the hydrophilic coatings technology licensed fromBiocoat for the Products listed in the attached Schedule A for the remainingterm of the Agreement.

In consideration of thisrepresentation of MTI, Biocoat agrees to replace the Royalty Rate Schedule of the Agreement, Schedule D, with the attached Schedule D, datedNovember 4, 2004.

Both parties to theAgreement hereby signify their approval of this Amendment.
| /s/Djoerd Hoekstra, President |     | /s/William H. Dippel               |   |   |
|-------------------------------|----------|------------------------------------|--------|--------|
| Djoerd Hoekstra, President    |     | William H. Dippel, V.P. Operations |   |   |
| Biocoat, Inc.                 |     | Micro Therapeutics, Inc.           |   |   |
| Date:                         | 12/09/04 |                               |   | Date:  | 12/10/04 |   |   |   |
|                               |          |                                    |        |        |  |  |  |  |

 

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SCHEDULE A

PRODUCTS
| ** **     | ** ** | **Model #**   | ** ** | **Description**          |
|----------------|------------|---------------|------------|--------------------------|
|           |       |          |       |                     |
| HYPERFORM      |       | 104-4470      |       | HYPERFORM 4.0 X 7 MM SYS |
| HYPERFORM      |       | 104-4770      |       | HYPERFORM 7.0 X 7 MM SYS |
| HYPERGLIDE     |       | 104-41 08     |       | HYPERGLIDE 15 MM ST BALL |
| HYPERGLIDE     |       | 104-4112      |       | HYPERGLIDE 4.0 X 15 MM,  |
| HYPERGLIDE     |       | 104-4113      |       | HYPERGLIDE 4.0X10 MM     |
| HYPERGLIDE     |       | 104-4120      |       | HYPERGLIDE, 10 MM ST BAL |
| HYPERGLIDE     |       | 104-4127      |       | HYPERGLIDE 4.0 X 20 MM,  |
| HYPERGLJDE     |       | 104-4130      |       | HYPERGLIDE 20MM ST BALL  |
| HYPERGLIDE     |       | 104-4131      |       | HYPERGLIDE 30 MM ST BALL |
| HYPERGLIDE     |       | 104-4132      |       | HYPERGLIDE SYSTEM- 30MM  |
| ULTRAFLOW      |       | 105-5065      |       | ULTRAFLOW HPC 1 .5F FLOW |
| ULTRAFLOW      |       | 105-5066      |       | ULTRAFLOW EXTENDED       |
| REBAR IR (FG)  |       | 105-5081-110  |       | REBAR-18, 110CM, MICRO C |
| REBAR IR (FG)  |       | 105-5081-130  |       | REBAR-18, 130CM, MICRO C |
| REBAR IR (FG)  |       | 105-5081-153  |       | REBAR-18, 153CM, M1CRO C |
| REBAR IR (FG)  |       | 105-5082-110  |       | REBAR-027, 110CM MICRO   |
| REBAR IR (FG)  |       | 105-5082-130  |       | REBAR-027, 130CM, MICRO  |
| REBAR IR (FG)  |       | 105-5082-145  |       | REBAR-027, 145CM, MICRO  |
| REBAR INR (FG) |       | 105-5078-153  |       | REBAR-l0, 153 CM, MICRO  |
| REBAR INR (FG) |       | 105-5078-153C |       | REBAR-l0, 153 CM, MICRO  |
| REBAR INR (FG) |       | 105-5078-1 70 |       | REBAR-l0, 170 CM, MICRO  |
| REBAR INR (FG) |       | 105-5078-170C |       | REBAR-l0, 170 CM, MICRO  |
| REBAR INR (FG) |       | 105-5080-143  |       | REBAR-14, 143CM, MICRO C |
| REBAR INR (FG) |       | 105-5080-143C |       | REBAR-14, 143CM, MICRO C |
| REBAR INR (FG) |       | 105-5080-153  |       | REBAR-14, 153CM, MICRO C |
| REBAR INR (FG) |       | 105-5080-153C |       | REBAR-14, 153CM, MICRO C |
| REBAR INR (FG) |       | 105-5080-1 70 |       | REBAR-14, 170CM MICRO CA |
| REBAR INR (FG) |       | 105-5080-170C |       | REBAR-14, 170CM MICRO    |
| REBAR INR (FG) |       | 105-5083-153  |       | REBAR-18, 153 MICRO CATH |
| REBAR INR (FG) |       | 105-5084-110  |       | REBAR-18, SOFT TIP, 110  |
| REBAR INR (FG) |       | 105-5084-130  |       | REBAR-18, SOFT TIP, 130  |
| REBAR INR (FG) |       | 105-5084-143  |       | REBAR-18, SOFT TIP, 143  |
| REBAR INR (FG) |       | 105-5084-153  |       | REBAR-18, SOFT TIP, 153  |
| REBAR INR (FG) |       | 105-5085-143  |       | REBAR-18, SOFT TIP, 143  |
| REBAR INR (FG) |       | 105-5085-153  |       | REBAR-18, SOFT TIP, 153  |
| ECHELON        |       | 105-5091-1 50 |       | ECHELON 10 MICRO         |
| ECHELON        |       | 105-5092-1 50 |       | ECHELON 14 MICRO         |
| ECHELON        |       | 145-5091-1 50 |       | ECHELON 10, 45 DEGREE    |
| ECHELON        |       | 190-5091-1 50 |       | ECHELON 10, 90 DEGREE    |
| ECHELON        |       | 145-8092-1 50 |       | ECHELON 14, 45 DEGREE    |
| ECHELON        |       | 190-5092-150  |       | ECHELON 14, 90 DEGREE    |
| NAUTICA (FG)   |       | 105-5094-153  |       | NAUTICA MICROCATHETER    |
| MARATHON       |       | 105-5055      |       | MARATHON MICROCATHETER   |

 

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SCHEDULE D

ROYALTY RATE SCHEDULE

ROYALTYRATE – Effective January 1, 2005

a.                                     For net sales up to $10 million U.S. dollarsin a given calendar year, the rate will be 1.5%

b.                                    For net sales in excess of$10 million U.Sdollars and up to $50 million U.S dollars in a calendar year, the rate will be1%.

c.                                     For net sales in excess of $50 million U.Sdollars in a given calendar year, the rate will be .5%.

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