**SERVICE      AGREEMENT**

|   | § | **SIRTON                PHARMACEUTICALS S.p.A.**,                whose registered office is in Villa Guardia (CO), Piazza XX Settembre                nr.                2, Tax Code 01192270138, represented by dr. Laura Iris Ferro, Deputy                Chairwoman (hereinafter referred to as **SIRTON**) |
|--------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | § | **GENTIUM                S.p.A.,**                whose registered office is in Villa Guardia (CO), Piazza XX Settembre                nr.                2. Tax Code 02098100130, represented by dr. Salvatore Calabrese,                Director                of Administration (hereinafter referred to as **GENTIUM);** |
|--------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

**WHEREAS:**

|  | § | **GENTIUM**                has asked SIRTON to provide various services (hereinafter referred                to as                the “Services” and  |
|--|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | § | **SIRTON**                has, within its own organisation, a structure dedicated to the performance                of all of the activities required to render said Services, |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1) | SIRTON                undertakes to provide GENTIUM with the Services indicated below and                described in the specific attachments.   |
|----|-------------------------------------------------------------------------------------------------------------------------------------------------------------|

| a)                  Quality control for batch release |   | Attachment                  A |
|-------------------------------------------------------|--------|-------------------------------|
| b)                  Analytical support for R&D    |   | Attachment                  B |
| c)                  Engineering services              |   | Attachment                  C |
| d)                  General services and car hire     |   | Attachment                  D |
| e)                  Services for utilities            |   | Attachment                  E |
| f)                  Maintenance service               |   | Attachment                  F |

| 2) | Unless                otherwise agreed by the parties, invoices will be issued on a monthly                basis and payment will be made by direct bank transfer 60 days from                the                end of the month in which the invoice is dated. |
|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3) | This                agreement will be effective as of 02/01/2006 and will expire on 31/12/2006                and will be considered tacitly renewed from year to year unless one                of the                parties gives notice to the other, sent at least one month before                expiry. |
|----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 4) | The                Parties reserve the right to revise the contractual conditions on                expiry                or during the life of the contract if there are any significant changes                to                the services rendered or the cost of                such. |
|----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 5) | The                Parties acknowledge, with immediate effect, the right to negotiate                variations of the fees established above on the basis of the actual                amount                of services rendered. |
|----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6) | Any                correspondence between the Parties must be addressed as                follows: |
|----|----------------------------------------------------------------------------------------------------|

**SIRTON**

**GENTIUM**

| 7) | This                agreement will be regulated by Italian law.  Any dispute regarding this Contract                will                be settled by a Board of Arbitration; each of the Parties will nominate                its own arbitrator, who in turn will choose the third member of the                Board                of Arbitration, who will act as Chairman of said                Board. |
|----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8) | This                Contract cancels and replaces all previous service agreements between                the                Parties and may not be amended or changed in any way with the exception                of                that expressly provided for herein or with the written agreement                of the                Parties signed by their authorised                representatives. |
|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9) | Together                with the issue of the invoice, Sirton undertakes to provide Gentium                with                all the support documentation and computation information (e.g. hour                sheets, statements of telephone costs as per charges made by telephone                service providers, vehicle hire invoices, certificates of analysis)                relative to the services rendered. If said support documentation                and proof                of the services rendered is not submitted, Gentium reserves the right                to                suspend payment of the invoice.   |
|----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|                                                                               |   |   |                                                                                               |
|------------------------------------------------------------------------------------|--------|--------|----------------------------------------------------------------------------------------------------|
| /s/ Laura              Iris Ferro                                             |   |   | /s/ Salvatore              Calabrese                                                          |
| **Sirton              Pharmaceuticals S.p.A**                                      |   |   | **Gentium              S.p.A.**                                                                    |
| Deputy                Chairwoman  *(dr.Laura                Iris Ferro)* |   |   | Director                of                Administration*(dr. Salvatore                Calabrese)* |

----

**ATTACHMENT      A**

**,      SIRTON **

**      GENTIUM**

| **Description**                          | **Full** | **Reduced** |
|------------------------------------------|----------|-------------|
| Certificates                of stability | 800.00   | 400.00      |

*For      batch releases:*

| **Product**                            | **Cost                of the certificate for batch analysis** |
|----------------------------------------|---------------------------------------------------------------|
| Injectable                Defibrotide  | 7,500.00                                                      |
| Oral                Defibrotide        | 5,600.00                                                      |
| Inject.                Calcium Heparin | 3,100.00                                                      |
| Raw                Heparin             | 400.00                                                        |
| Heparin                Std Bottles     | 1,000.00                                                      |
| Pure                Urokinase          | 3,000.00                                                      |
| Sulglicotide                           | 2,650.00                                                      |
| Glucidamine                            | 2,300.00                                                      |

----

**ATTACHMENT      B**

**SIRTON**

**SIRTON**

----

**ATTACHMENT      C**

**SIRTON**

----

**ATTACHMENT      D**

**SIRTON**

**SIRTON**

**Telephone      expenses**
** **

**Other      general services**

| Switchboard                and door staff |                                            | €                875 + VAT                                |
|-------------------------------------------|-------------------------------------------------|-----------------------------------------------------------------|
| Security                                  | €                2,980+VAT until February | €                2,280+ VAT from 1st                March |
| Delivery/errand                staff      | €                3,600 + VAT January      | €                1,800 + VAT February                     |
| Laundry                                   | €                1,200+ VAT to January    | €                600 + VAT February                       |

**The      delivery and laundry services will terminate from March      2006.**

| Hire of photocopiers 3rd              floor Gentium office block |                                                                  |
|------------------------------------------------------------------|-----------------------------------------------------------------------|
| (dr. Moltrasio - Mr. Cislaghi)                                   | **hire instalment recharged until              transfer of contract** |

**Cars**
** **

----

**ATTACHMENT      E**

**SIRTON      **

**SIRTON**

**SIRTON      **

----

**ATTACHMENT      F**

**SIRTON      **

**      SIRTON**

**€      25.00 + VAT.**

----

**Attachment      “A”**

**TO      THE CONTRACT TO SUPPLY ACTIVE INGREDIENTS BETWEEN **

**SIRTON      PHARMACEUTICALS S.p.A and GENTIUM S.p.A. dated 2/01/2006**

**Price      for sale of active ingredients 2006**

| **Product**                       | **Unit                  of measure** | **Unit                price** |
|----------------------------------------|--------------------------------------|-------------------------------|
| Pure                Urokinase          | M.U.                                 | 53.00                         |
| Inject.                Calcium Heparin | M.U.                                 | 8.80                          |
| Inject.                Defibrotide     | K.S.                                 | 2,300.00                      |
| Oral                Defibrotide        | K.S.                                 | 660.00                        |
| Sulglicotide                           | K.S.                                 | 390.00                        |
| Glucidamine                            | K.S.                                 | 160.00                        |

| **Sirton Pharmaceuticals              S.p.A**     Deputy                Chairwoman    (*dr.                Laura Iris Ferro)*   *            * |   |   |  **Gentium              S.p.A.**Director                of Administration*(dr.                Salvatore Calabrese)* |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|--------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                   |   |   |                                                                                                                     |
|                                                                                                                                                                                                                                                                   |   |   |                                                                                                                     |
| /s/ Laura              Iris Ferro                                                                                                                                                                                                                                 |   |   | /s/ Salvatore              Calabrese                                                                                |
|                                                                                                                                                                                                                                                                        |   |   |                                                                                                                          |
|                                                                                                                                                                                                                                                                   |   |   |                                                                                                                     |

**Sirton      Pharmaceuticals S.p.A**
**Gentium      S.p.A.**

*dr.      Laura Iris Ferro)*
*                   (dr. Salvatore Calabrese)*

----