**SERVICE      AGREEMENT**

**FINSIRTON      S.p.A.**
**FINSIRTON**

**AND**

**GENTIUM      S.P.A.**
**GENTIUM”**

**WHEREAS      **

| **A)** | **GENTIUM**wishes                to use FINSIRTON’s organisation and expertise in performing the activities                illustrated herein, and FINSIRTON is willing to perform said activities                for GENTIUM . |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| **B)** | **FINSIRTON**                and GENTIUM intend to formalise the provision by FINISIRTON of the                various                services described herein to                GENTIUM. |
|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| **C)** | Hereinafter                GENTIUM will be referred to as the “**Principal**”                and FINSIRTON as the “**Agent**” |
|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------|

**NOW,      THEREFORE, THE PARTIES AGREE THE FOLLOWING:**

| 1) | **FINSIRTON**                undertakes to perform the activities listed and illustrated below                for                GENTIUM: |
|----|-------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | **Personnel                administration**                -                The Principal assigns the Agent with the administration of its personnel,                providing all of the information required so that the Agent may comply                with the provisions of legislation in force, particularly as regards                tax                and social security aspects. |
|--------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 2) | The                fee to be paid to FINSIRTON for the activity provided under this                contract                will be calculated as follows: |
|----|-----------------------------------------------------------------------------------------------------------------------------------------------------------|

**Personnel      services**

| ü | **General                administrative costs:**                refer to secretarial activities performed on behalf of Gentium entailing                updating the company’s books, registering administrative documents and                managing the vehicle fleet, calculated on a lump-sum basis of € 48,000/per                year + VAT established on the basis of the costs incurred and charged                in                accordance with the percentage incidence of GENTIUM’s turnover within the                Finsirton Group. Monthly invoice of € 4,000 +                VAT. |
|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| ü | Invoices                will be paid by direct bank transfer, 60 days from the end of the                month in                which the invoice is dated. |
|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3) | The                Contract will be effective as of January 2, 2006 and will expire                December                31, 2006, and will be considered tacitly renewed from year to year                unless                one of the parties gives notice to the other, the latter must be                notified                one month in advance. |
|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 4) | All                correspondence regarding this Contract must be made in writing and                sent by                hand, by fax, telegram or registered mail with return receipt to                the                registered office of each Party. |
|----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5) | Any                dispute regarding this Contract will be settled by a Board of Arbitration;                each of the Parties will nominate its own arbitrator, who in turn                will                choose the third member of the Board of Arbitration, who will act                as                Chairman of said Board. |
|----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6) | This                Contract cancels and replaces all previous service agreements between                the                Parties and may not be amended or changed in any way with the exception                of                that expressly provided for herein or with the written agreement                of the                Parties signed by their authorised                representatives. |
|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|                                                           |   |   |                                                                                      |
|----------------------------------------------------------------|--------|--------|-------------------------------------------------------------------------------------------|
| **/s/** **Laura              Iris Ferro**                 |   |   | **/s/** **Salvatore              Calabrese**                                    |
| **FINSIRTON              S.p.A.**                              |   |   | **GENTIUM              S.p.A.**                                                           |
| ** **Sole                Director*(dr. Laura Iris Ferro)* |   |   | Director                of                Administration*(dr. Salvatore Calabrese)*  |