# ATTACHMENT 2: Boric Acid and Sodium

Borate Salts Case

— ECOTOX Studies

Summary Tables

Contents

Aquatic Animal Studies

Table 1 for Aquatic Animal Studies (comparable species and endpoints) Boric Acid Case

........................................... 2

Freshwater fish, Acute

................................................................................................ ..................................... 2

Freshwater fish, Chronic

................................................................................................ .................................. 8

Freshwater arthropods , Acute

...................................................................................................................... 13

F reshwater arthropods, Chronic

................................................................................................................... 20

Marine/estuarine fish, Acute

........................................................................................................................ 23

Marine /estuarine crustaceans, Acute

........................................................................................................... 34

Table 2 for Aquatic Animal Studies (species not comparable) Boric Acid Case

........................................................... 38

Other aquatic animals, Acute

........................................................................................................................ 39

Table 3 for Aquatic Animal Studies (endpoints not comparable) Boric Acid Case

...................................................... 43

Freshwater fish, Other

................................................................................................ .................................. 43

Marine /estuari ne crustaceans, Other

........................................................................................................... 44

Mar ine/estuarine mollusks, Other

................................................................................................................ 45

Other aquatic animals, Other

........................................................................................................................ 45

Aquatic Plant Studies

Table 1 for Aquatic Plant Studies (comparable species and endpoints) Boric Acid Case

............................................ 49

Table 2 for Aquatic Plant Studies (species not comparable) Boric Acid Case

.......................................... Not applicable

Table 3 for Aquatic Plant Studies (endpoints not comparable) Boric Acid Case

.................................. None in ECOTOX

Terrestrial Animal Studies

Table 1 for Terrestrial Animal Studies (comparable species and endpoints) Boric Acid Case

..................................... 51

Birds, Acute

................................................................................................ ................................................... 51

Birds, Chronic

................................................................................................ ................................................ 51

Rodent, Chronic

................................................................................................ ............................................. 55

Honeybee, Subacute

................................................................................................ ..................................... 75

Table 2 for Terrestrial Animal Studies (species not comparable) Boric Ac id Case

...................................................... 76

Other terrestrial animals, Chronic

................................................................................................................. 76

Table 3 for Terrestrial Animal Studies (endpoints not comparable) Boric Acid Case

.................................................. 87

Birds, Other

................................................................................................ ................................................... 87

Rodent, Other

................................................................................................ ................................................ 94

Honeybee, Other

................................................................................................ ......................................... 11 3

Other terrestrial animals, Other

.................................................................................................................. 11 4

Terrestrial Plant Studies

Table 1 for Terrestrial Plant Studies (comparable species a nd endpoints) Boric Acid Case

...................................... 13 4

Terrestrial monocots, Acute

........................................................................................................................ 134

Terrestrial dicots, Acute

.............................................................................................................................. 149

Table 2 for Terrestrial Plant Studies (species not comparable) Boric Acid Case

....................................................... 177

Other terrestrial plants and fungi

................................................................................................................ 177

Table 3 for Terrestrial Plant Studies (endpoints not comparable) Boric Acid Case

................................................... 1 78

Terrestr ial monocots, Other

........................................................................................................................ 178

Terrestrial dicots, Other

.............................................................................................................................. 198Table 1 for Aquatic Animal Studies(comparable species and endpoints)Boric Acid CaseCAS Number:1330434PC Code:Download Date:11/4/2014Freshwater fishTaxa_Code:FWFAcuteRef #508Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Wallen IE;Greer WC;Lasater RYear:1957Source:Sewage Ind. Wastes 29(6): 695-711AgeLifestageFormul.CAS Number:1330434Title:ToxicitytoGambusia affinis ofCertainPureChemicalsinTurbid WatersTestChemical:Sodiumtetraborate decahydrate(B4Na2O710H2O)ast.s.andBoricacidasa.e.Western MosquitofishMORMORT FW(Gambusia affinis)MOR2. d TLC50: 8200 mg/LNR1 100 LAB S 8.6 to9.1NROrig:8200 ppmOrig:ppmADPUWestern MosquitofishMORMORT FW(Gambusia affinis)MOR1. d TLC50: 18000 mg/LNR1 100 LAB S 5.4 to7.3NROrig:18000 ppmOrig:ppmADPUWestern MosquitofishMORMORT FW(Gambusia affinis)MOR4. d TLC50: 3600 mg/LNR1 100 LAB S 8.6 to9.1NROrig:3600 ppmOrig:ppmADPUWestern MosquitofishMORMORT FW(Gambusia affinis)MOR6. d TLC50: 1900 mg/LNR1 100 LAB S 8.6 to9.1NROrig:1900 ppmOrig:ppmADPUWestern MosquitofishMORMORT FW(Gambusia affinis)MOR1. d TLC50: 12000 mg/LNR1 100 LAB S 8.6 to9.1NROrig:12000 ppmOrig:ppmADPUWestern MosquitofishMORMORT FW(Gambusia affinis)MOR4. d TLC50: 5600 mg/LNR1 100 LAB S 5.4 to7.3NROrig:5600 ppmOrig:ppmADPUWestern MosquitofishMORMORT FW(Gambusia affinis)MOR2. d TLC50: 10500 mg/LNR1 100 LAB S 5.4 to7.3NROrig:10500 ppmOrig:ppmADPUMonday, June 15, 2015Page 1 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Boric acidBoric acidBoric acidSodiumtetetraboratedecahydrateSodiumtetetraboratedecahydrateSodiumtetetraboratedecahydrateSodiumtetetraboratedecahydrateRef #922Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Turnbull H;Demann JG;Weston RFTitle:Toxicity of Various Refinery Materials to Fresh Water FishYear:1954Source:J. Ind. Eng. Chem. 46(2): 324-333AgeLifestageFormul.CAS Number:1330434Test Chemical:Boron sodium oxide (B4Na2O7)BluegillMORMORT FW(Lepomis macrochirus)MOR1. d TLC50*: 15 mg/LNR100 LAB S 6.9 to7.584.0 to 163 mg/LCaCO3Orig:15000 ug/LOrig:ug/LRef #5969Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Birge WJ;Black JAYear:1977Source:"EPA 560/1-76-008, U.S.EPA, Washington DC : 66 p."AgeLifestageFormul.CAS Number:10043353Title:SensitivityofVertebrateEmbryos toBoronCompoundsTest Chemical:Boricacid (H3BO3)as a.e.andSodiumTetraborateDecahydrate (B4Na2O410H2O)as t.s.Channel CatfishMORMORT FW(Ictalurus punctatus)MOR5. d TLC50*: 102 mg/LNR100 LAB F 7.6 200 mg/L CaCO3Orig:102000 ug/LOrig:ug/LEMChannel CatfishMORMORT FW(Ictalurus punctatus)MOR5. d TLC50*: 120 mg/LNR100 LAB F 8.2 200 mg/L CaCO3Orig:120000 ug/LOrig:ug/LEMChannel CatfishMORMORT FW(Ictalurus punctatus)MOR5. d TLC50*: 220 mg/LNR100 LAB F 7.5 50 mg/L CaCO3Orig:220000 ug/LOrig:ug/LEMChannel CatfishMORMORT FW(Ictalurus punctatus)MOR5. d TLC50*: 235 mg/LNR100 LAB F 8.5 50 mg/L CaCO3Orig:235000 ug/LOrig:ug/LEMGoldfishMORMORT FW(Carassius auratus)MOR3. d TLC50*: 178 mg/LNR100 LAB F 7.9 50 mg/L CaCO3Orig:178000 ug/LOrig:ug/LEMGoldfishMORMORT FW(Carassius auratus)MOR3. d TLC50*: 71 mg/LNR100 LAB F 7.9 50 mg/L CaCO3Orig:71000 ug/LOrig:ug/LEMGoldfishMORMORT FW(Carassius auratus)MOR3. d TLC50*: 68 mg/LNR100 LAB F 8.1 200 mg/L CaCO3Orig:68000 ug/LOrig:ug/LEMMonday, June 15, 2015Page 2 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.expressed as B2O3equivalentsSodiumTetraborateDecahydrateBoric acidBoric acidBoric acidBoric acidSodiumTetraborateDecahydrateSodiumTetraborateDecahydrateRef #5969Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Birge WJ;Black JAYear:1977Source:"EPA 560/1-76-008, U.S.EPA, Washington DC : 66 p."AgeLifestageFormul.CAS Number:10043353Title:SensitivityofVertebrateEmbryos toBoronCompoundsTest Chemical:Boricacid (H3BO3)asa.e.and Sodium Tetraborate Decahydrate (B4Na2O4 10HO)GoldfishMORMORT FW(Carassius auratus)MOR3. d TLC50*: 170 mg/LNR100 LAB F 7.6 200 mg/L CaCO3Orig:170000 ug/LOrig:ug/LEMRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR1. d TLC50*: 150 mg/LNR100 LAB F 7.7 50 mg/L CaCO3Orig:150000 ug/LOrig:ug/LEMRef #14566Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Terhaar CJ;Ewell WS;Dziuba SP;Fassett DWYear:1972Source:Photogr. Sci. Eng. 16(5): 370-377AgeLifestageFormul.CAS Number:10043353Title:Toxicity of PhotographicProcessingChemicals toFishTest Chemical:Boricacid (H3BO3)as a.e.Fathead MinnowMORMORT FW(Pimephales promelas)MOR0.417 d TLT50: 10000 mg/LNR100 LAB S 6.5 to8.582* mg/L CaCO3Orig:10000 mg/LOrig:mg/LFathead MinnowMORMORT FW(Pimephales promelas)MOR>4. d TLT50: 100 mg/LNR100 LAB S 6.5 to8.582* mg/L CaCO3Orig:100 mg/LOrig:mg/LFathead MinnowMORMORT FW(Pimephales promelas)MOR3.292 d TLT50: 1000 mg/LNR100 LAB S 6.5 to8.582* mg/L CaCO3Orig:1000 mg/LOrig:mg/LFathead MinnowMORMORT FW(Pimephales promelas)MOR1. d TNR-LETH: 10000 mg/LNR100 LAB S 6.5 to8.582* mg/L CaCO3Orig:10000 mg/LOrig:mg/LMonday, June 15, 2015Page 3 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Boric acidSodiumTetraborateDecahydrateRef #15346Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hamilton SJYear:1995Source:Ecotoxicol. Environ. Saf. 30(2): 134-142AgeLifestageFormul.CAS Number:10043353Title:"Hazard Assessmentof InorganicstoThree EndangeredFish in theGreenRiver,Utah"Test Chemical:Boricacid (H3BO3)as a.e.BonytailMORMORT FW(Gila elegans)MOR4. dTLC50: 552 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:552000 ug/LOrig:ug/L220 to234 dJVBonytailMORMORT FW(Gila elegans)MOR4. dTLC50: 280 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:280000 ug/LOrig:ug/L11 to18 dSUBonytailMORMORT FW(Gila elegans)MOR4. dTLC50: >100 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:>100000 ug/LOrig:ug/L138 to145 dJVColorado SquawfishMORMORT FW(Ptychocheilus lucius)MOR4. dTLC50: 527 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:527000 ug/LOrig:ug/L193 to207 dJVColorado SquawfishMORMORT FW(Ptychocheilus lucius)MOR4. dTLC50: >100 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:>100000 ug/LOrig:ug/L99 to115 dJVColorado SquawfishMORMORT FW(Ptychocheilus lucius)MOR4. dTLC50: 279 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:279000 ug/LOrig:ug/L17 to31 dSUColorado SquawfishMORMORT FW(Ptychocheilus lucius)MOR4. dTNR-LETH: 360 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:360000 ug/LOrig:ug/L17 to31 dSUColorado SquawfishMORMORT FW(Ptychocheilus lucius)MOR4. dTNR-ZERO: 216 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:216000 ug/LOrig:ug/L17 to31 dSURazorback SuckerMORMORT FW(Xyrauchen texanus)MOR4. dTLC50: >100 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:>100000 ug/LOrig:ug/L176 to186 dJVMonday, June 15, 2015Page 4 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #15346Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hamilton SJYear:1995Source:Ecotoxicol. Environ. Saf. 30(2): 134-142AgeLifestageFormul.CAS Number:10043353Title:"Hazard Assessmentof InorganicstoThree EndangeredFish in theGreenRiver,Utah"Test Chemical:Boricacid (H3BO3)as a.e.Razorback SuckerMORMORT FW(Xyrauchen texanus)MOR4. d TLC50: 233 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:233000 ug/LOrig:ug/L10 to17 dSURazorback SuckerMORMORT FW(Xyrauchen texanus)MOR4. d TLC50: 279 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:279000 ug/LOrig:ug/L133 to139 dJVRazorback SuckerMORMORT FW(Xyrauchen texanus)MOR4. d TNR-LETH: 360 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:360000 ug/LOrig:ug/L133 to139 dJVRazorback SuckerMORMORT FW(Xyrauchen texanus)MOR4. d TNR-ZERO: 216 mg/LNR100 LAB S 7.0 to8.5196* (182* to201*) mg/LCaCO3Orig:216000 ug/LOrig:ug/L133 to139 dJVRef #18979Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hamilton SJ;Buhl KJTitle:"Hazard Evaluation of Inorganics, Singly and in Mixtures, to Flannelmouth Sucker Catostomuslatipinnis in the San Juan River, New Mexico"Year:1997Source:Ecotoxicol. Environ. Saf. 38(3): 296-308AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsFlannelmouth SuckerMORMORT FW(Catostomus latipinnis)MOR4. d TLC50: 125 mg/LNR100 LAB S 7.4 to7.9144 mg/L CaCO3Orig:125000 ug/LOrig:ug/L12 to13 dLVFlannelmouth SuckerMORMORT FW(Catostomus latipinnis)MOR3. d TLC50: 225 mg/LNR100 LAB S 7.4 to7.9144 mg/L CaCO3Orig:225000 ug/LOrig:ug/L12 to13 dLVMonday, June 15, 2015Page 5 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #18979Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hamilton SJ;Buhl KJTitle:"Hazard Evaluation of Inorganics, Singly and in Mixtures, to Flannelmouth Sucker Catostomuslatipinnis in the San Juan River, New Mexico"Year:1997Source:Ecotoxicol. Environ. Saf. 38(3): 296-308AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsFlannelmouth SuckerMORMORT FW(Catostomus latipinnis)MOR2. d TLC50: 337 mg/LNR100 LAB S 7.4 to7.9144 mg/L CaCO3Orig:337000 ug/LOrig:ug/L12 to13 dLVFlannelmouth SuckerMORMORT FW(Catostomus latipinnis)MOR1. d TLC50: 1000 mg/LNR100 LAB S 7.4 to7.9144 mg/L CaCO3Orig:1000000 ug/LOrig:ug/L12 to13 dLVRef #19124Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Birge WJ;Black JA;Westerman AG;Ramey BAYear:1983Source:Fundam. Appl. Toxicol. 3: 237-242AgeLifestageFormul.CAS Number:10043353Title:Fishand AmphibianEmbryos -aModel SystemforEvaluating TeratogenicityTest Chemical:Boricacid (H3BO3)as Boron equivalentsRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR4. dph TLC50: 79 mg/LNR100 LAB F 7.0 to7.8200 mg/L CaCO3Orig:79 mg/LOrig:mg/LEMRef #105984Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Rowe RI;Bouzan C;Nabili S;Eckhert CDTitle:The Response of Trout and Zebrafish Embryos to Low and High Boron Concentrations is UShapedYear:1998Source:Biol. Trace Elem. Res. 66(1-3): 261-270AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsZebra DanioMORMORT FW(Danio rerio)MOR4. d TNOAEL: 1.2 mmol/LLOAEL: 9.2 mmol/L 5 99.5 LAB S 7.2 to7.4*NROrig:1.2 mmol/LOrig:9 mmol/L<1 dpf EGMonday, June 15, 2015Page 6 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #158995Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Selderslaghs IWT;Blust R;Witters HETitle:Feasibility Study of the Zebrafish Assay as an Alternative Method to Screen for DevelopmentalToxicity and Embryotoxicity Using a Training Set of 27 CompoundsYear:2012Source:Reprod. Toxicol. 33(2): 142-154AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)asa.e.(multiplymMby61.81togetmga.e./L)Zebra DanioMORMORT FW(Danio rerio)MOR5.833 d TLC50: 23.55 mMNR1 100 LAB S 6.8 to 8 217* to 235*mg/L CaCO3Orig:23.55 mMOrig:mM4 hpf EMZebra DanioMORMORT FW(Danio rerio)MOR2.833 d TLC50: 42.2 mMNR1 100 LAB S 6.8 to 8 217* to 235*mg/L CaCO3Orig:42.2 mMOrig:mM4 hpf EMZebra DanioMORMORT FW(Danio rerio)MOR1.833 d TLC50: 63.17 mMNR1 100 LAB S 6.8 to 8 217* to 235*mg/L CaCO3Orig:63.17 mMOrig:mM4 hpf EMRef #166376Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Teixido E;Pique E;Gomez-Catalan J;Llobet JMYear:2013Source:Toxicol. In Vitro 27: 469-478AgeLifestageFormul.CAS Number:10043353Title:AssessmentofDevelopmentalDelayin theZebrafishEmbryoTeratogenicityAssayTest Chemical:Boricacid (H3BO3)as a.e. (multiply mM by 61.81 to get mg a.e./L)Zebra DanioMORMORT FW(Danio rerio)MOR2. d TLC50: 53.4 mMNR1 100 LAB R 7.4*NROrig:53.4 mMOrig:mM4 hpf EMChronicRef #451Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Thompson JAJ;Davis JC;Drew REYear:1976Source:Water Res. 10(10): 869-875AgeLifestageFormul.CAS Number:7775191Title:"Toxicity,Uptakeand SurveyStudies ofBoron in theMarineEnvironment"Test Chemical:"Boricacid (HBO2), sodiumsalt"expressed as Boron equivalentsMonday, June 15, 2015Page 7 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #451Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Thompson JAJ;Davis JC;Drew REYear:1976Source:Water Res. 10(10): 869-875AgeLifestageFormul.CAS Number:7775191Title:"Toxicity,Uptakeand SurveyStudies ofBoron in theMarineEnvironment"Test Chemical:"Boricacid (HBO2), sodiumsalt"expressedasBoronequivalentsSilver SalmonMORMORT FW(Oncorhynchus kisutch)MOR11.8 d TLC50: 113 mg/LNR100 LAB R 7.0(6.85 to47 mg/L CaCO3Orig:113000 ug/LOrig:ug/LALRef #5969Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Birge WJ;Black JAYear:1977Source:"EPA 560/1-76-008, U.S.EPA, Washington DC : 66 p."AgeLifestageFormul.CAS Number:1303964Title:SensitivityofVertebrateEmbryos toBoronCompoundsTest Chemical:Borax (B4Na2O7.10H2O)as t.s. and Boric acid as a.e.Channel CatfishMORMORT FW(Ictalurus punctatus)MOR9. d TLC50*: 71 mg/LNR100 LAB F 8.2 200 mg/L CaCO3Orig:71000 ug/LOrig:ug/LFYChannel CatfishMORMORT FW(Ictalurus punctatus)MOR9. d TLC50*: 155 mg/LNR100 LAB F 7.5 50 mg/L CaCO3Orig:155000 ug/LOrig:ug/LFYChannel CatfishMORMORT FW(Ictalurus punctatus)MOR9. d TLC50*: 22 mg/LNR100 LAB F 7.6 200 mg/L CaCO3Orig:22000 ug/LOrig:ug/LFYChannel CatfishMORMORT FW(Ictalurus punctatus)MOR9. d TLC50*: 155 mg/LNR100 LAB F 8.5 50 mg/L CaCO3Orig:155000 ug/LOrig:ug/LFYGoldfishMORMORT FW(Carassius auratus)MOR7. d TLC50*: 65 mg/LNR100 LAB F 7.9 50 mg/L CaCO3Orig:65000 ug/LOrig:ug/LFYGoldfishMORMORT FW(Carassius auratus)MOR7. d TLC50*: 59 mg/LNR100 LAB F 8.1 200 mg/L CaCO3Orig:59000 ug/LOrig:ug/LFYGoldfishMORMORT FW(Carassius auratus)MOR7. d TLC50*: 46 mg/LNR100 LAB F 7.9 50 mg/L CaCO3Orig:46000 ug/LOrig:ug/LFYMonday, June 15, 2015Page 8 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Boric acidBoric acidSodiumTetraborateDecahydrateSodiumTetraborateDecahydrateSodiumTetraborateDecahydrateBoric acidSodiumTetraborateDecahydrateRef #5969Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Birge WJ;Black JAYear:1977Source:"EPA 560/1-76-008, U.S.EPA, Washington DC : 66 p."AgeLifestageFormul.CAS Number:1303964Title:SensitivityofVertebrateEmbryos toBoronCompoundsTest Chemical:Borax (B4Na2O7.10H2O)as t.s. and Boric acid as a.e.GoldfishMORMORT FW(Carassius auratus)MOR7. d TLC50*: 75 mg/LNR100 LAB F 7.6 200 mg/L CaCO3Orig:75000 ug/LOrig:ug/LFYRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR28. d TLC50*: 54 mg/LNR100 LAB F 7.8 200 mg/L CaCO3Orig:54000 ug/LOrig:ug/LALRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR24. d TLC50*: 65 mg/LNR100 LAB F 7.9 50 mg/L CaCO3Orig:65000 ug/LOrig:ug/LEMRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR28. d TLC50*: 100 mg/LNR100 LAB F 7.7 50 mg/L CaCO3Orig:100000 ug/LOrig:ug/LALRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR24. d TLC50*: 88 mg/LNR100 LAB F 7.8 200 mg/L CaCO3Orig:88000 ug/LOrig:ug/LEMRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR28. d TLC50*: 79 mg/LNR100 LAB F 7.9 200 mg/L CaCO3Orig:79000 ug/LOrig:ug/LALRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR28. d TLC50*: 27 mg/LNR100 LAB F 7.9 50 mg/L CaCO3Orig:27000 ug/LOrig:ug/LALRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR24. d TLC50*: 100 mg/LNR100 LAB F 7.9 200 mg/L CaCO3Orig:100000 ug/LOrig:ug/LEMRef #7044Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Black JA;Barnum JB;Birge WJYear:1993Source:Chemosphere 26(7): 1383-1413AgeLifestageFormul.CAS Number:10043353Title:AnIntegratedAssessmentofthe BiologicalEffects ofBoron totheRainbowTroutTest Chemical:Boricacid (H3BO3)as Boron equivalentsMonday, June 15, 2015Page 9 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Boric acidSodiumTetraborateDecahydrateSodiumTetraborateDecahydrateBoric acidSodiumTetraborateDecahydrateSodiumTetraborateDecahydrateBoric acidBoric acidRef #7044Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Black JA;Barnum JB;Birge WJYear:1993Source:Chemosphere 26(7): 1383-1413AgeLifestageFormul.CAS Number:10043353Title:AnIntegratedAssessmentofthe BiologicalEffects ofBoron totheRainbowTroutTest Chemical:Boricacid (H3BO3)as Boron equivalentsLargemouth BassMORMORT FW(Micropterus salmoides)MOR11. d TLC50: 92 mg/LNR100 LAB F 7.5 204 mg/L CaCO3Orig:92000 ug/LOrig:ug/LMXLargemouth BassMORMORT FW(Micropterus salmoides)MOR11. d TLOEC: 12.17 mg/LNR100 LAB F 7.5 204 mg/L CaCO3Orig:12170 ug/LOrig:ug/LMXLargemouth BassMORMORT FW(Micropterus salmoides)MOR11. d TNOEC: 1.39 mg/LNR100 LAB F 7.5 204 mg/L CaCO3Orig:1390 ug/LOrig:ug/LMXRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR32. d TLC50: 138 mg/LNR100 LAB F 7.4 197 mg/L CaCO3Orig:138000 ug/LOrig:ug/LMXRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR28. d TLOEC: 1-18 mg/LNR100 LAB F 7.7* 188* mg/LCaCO3Orig:Orig:ug/LMXRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR32. d TLOEC: 0.1 mg/LNR100 LAB F 7.4 197 mg/L CaCO3Orig:100 ug/LOrig:ug/LMXRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR87. d TNOEC: 2.1 mg/LNR100 LAB F 6.8* to7.1*24* to 39* mg/LCaCO3Orig:2100 ug/LOrig:ug/LMXRef #11838Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Birge WJ;Black JA;Westerman AG;Hudson JEYear:1980Source:"In: C.Gale (Ed.), EPA-600/9-80-022, Oil Shale Symposium: Sampling, Analysisand Quality Assurance,AgeLifestageFormul.CAS Number:10043353Title:Aquatic ToxicityTests on Inorganic ElementsOccurringinOil ShaleTest Chemical:Boricacid (H3BO3)as Boron equivalentsRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR28. d TLC50: 70.1 mg/LNR100 LAB R 6.9 to7.892 to 110 mg/LCaCO3Orig:70100 ug/LOrig:ug/LEGMonday, June 15, 2015Page 10 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #105984Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Rowe RI;Bouzan C;Nabili S;Eckhert CDTitle:The Response of Trout and Zebrafish Embryos to Low and High Boron Concentrations is UShapedYear:1998Source:Biol. Trace Elem. Res. 66(1-3): 261-270AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsRainbow TroutMORMORT FW(Oncorhynchus mykiss)MOR42. d TNOAEL: 8 mmol/LLOAEL: 10 mmol/L5 99.5 LAB S 7.2 to7.4*NROrig:8 mmol/LOrig:10 mmol/L<1 dpf EGRef #158995Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Selderslaghs IWT;Blust R;Witters HETitle:Feasibility Study of the Zebrafish Assay as an Alternative Method to Screen for DevelopmentalToxicity and Embryotoxicity Using a Training Set of 27 CompoundsYear:2012Source:Reprod. Toxicol. 33(2): 142-154AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as a.e. (multiply mM by 61.81 to ge mg a.i./L)Zebra DanioGROABNM FW(Danio rerio)DVP0.833 d TEC50: 63.54 mMNR1 100 LAB S 6.8 to 8 217* to 235*mg/L CaCO3Orig:63.54 mMOrig:mM4 hpf EMZebra DanioGROABNM FW(Danio rerio)DVP2.833 d TEC50: 23.45 mMNR1 100 LAB S 6.8 to 8 217* to 235*mg/L CaCO3Orig:23.45 mMOrig:mM4 hpf EMZebra DanioGROABNM FW(Danio rerio)DVP1.833 d TEC50: 25.24 mMNR1 100 LAB S 6.8 to 8 217* to 235*mg/L CaCO3Orig:25.24 mMOrig:mM4 hpf EMZebra DanioGROABNM FW(Danio rerio)DVP5.833 d TEC50: 5.85 mMNR1 100 LAB S 6.8 to 8 217* to 235*mg/L CaCO3Orig:5.85 mMOrig:mM4 hpf EMMonday, June 15, 2015Page 11 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #166376Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Teixido E;Pique E;Gomez-Catalan J;Llobet JMYear:2013Source:Toxicol. In Vitro 27: 469-478AgeLifestageFormul.CAS Number:10043353Title:AssessmentofDevelopmentalDelayin theZebrafishEmbryoTeratogenicityAssayTest Chemical:Boricacid (H3BO3)as a.e. (multiply by 61.81 to get mg a.e./L)Zebra DanioGROABNM FW(Danio rerio)DVP2. d TEC10: 17.5 mMNR1 100 LAB R 7.4*NROrig:17.5 mMOrig:mM4 hpf EMZebra DanioGROABNM FW(Danio rerio)DVP2. d TEC50: 18.3 mMNR1 100 LAB R 7.4*NROrig:18.3 mMOrig:mM4 hpf EMZebra DanioGROABNM FW(Danio rerio)DVP2. d TLOAEL: ~15 mMNR1 100 LAB R 7.4*NROrig:~15 mMOrig:mM4 hpf EMZebra DanioGROABNM FW(Danio rerio)DVP2. d TNOAEL: ~10 mMNR1 100 LAB R 7.4*NROrig:~10 mMOrig:mM4 hpf EMFreshwater arthropodsTaxa_Code:FWARAcuteRef #190Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Maier KJ;Knight AWTitle:The Toxicity of Waterborne Boron to Daphnia magna and Chironomus decorus and the EffectsYear:1991Source:Arch. Environ. Contam. Toxicol. 20(2): 282-287AgeLifestageFormul.CAS Number:1330434ofWater Hardness and Sulfate on BoronToxicityTest Chemical:Boron sodiumoxide (B4Na2O7)as Boron equivalentsMidgeMORMORT FW(Chironomus decorus)MOR2. d TLC50: 1376 mg/LNR100 LAB R 9.1NROrig:1376000 ug/LOrig:ug/L4 ins LVWater FleaMORMORT FW(Daphnia magna)MOR2. d TLC50: 141 mg/LNR100 LAB R 9.1NROrig:141000 ug/LOrig:ug/LNEMonday, June 15, 2015Page 12 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #2130Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Anderson BGYear:1946Source:Sewage Works J. 18(1): 82-87AgeLifestageFormul.CAS Number:1330434Title:TheToxicityThresholds ofVarious SodiumSalts DeterminedbytheUse ofDaphniamagnaTest Chemical:Boron sodiumoxide (B4Na2O7)as t.s.Water FleaPHYIMBL FW(Daphnia magna)ITX2. d TNOAEL: <240 mg/LNR100 LAB NRNROrig:<240000 ug/LOrig:ug/LRef #4785Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Lewis MA;Valentine LCYear:1981Source:Bull. Environ. Contam. Toxicol. 27(3): 309-315AgeLifestageFormul.CAS Number:10043353Title:Acute and ChronicToxicitiesofBoric AcidtoDaphnia magna StrausTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Daphnia magna)MOR2. d TLC50: 226 mg/LNR100 LAB S 7.1 to8.7166 (135 to 217)mg/L CaCO3Orig:226000 ug/LOrig:ug/L<24 hWater FleaMORMORT FW(Daphnia magna)MOR2. d TNR-ZERO: <200 mg/LNR100 LAB S 7.1 to8.7166 (135 to 217)mg/L CaCO3Orig:<200000 ug/LOrig:ug/L<24 hRef #8764Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hickey CWYear:1989Source:N. Z. J. Mar. Freshw. Res. 23(1): 131-137AgeLifestageFormul.CAS Number:10043353Title:SensitivityofFourNewZealandCladoceranSpecies andDaphniamagnatoAquaticToxicantsTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Daphnia magna)MOR1. d TEC10: 250 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:250 g/m3Orig:g/m3<24 h NEWater FleaMORMORT FW(Daphnia carinata)MOR1. d TEC10: 138.8 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:138.8 g/m3Orig:g/m3<24 h NEMonday, June 15, 2015Page 13 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #8764Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hickey CWYear:1989Source:N. Z. J. Mar. Freshw. Res. 23(1): 131-137AgeLifestageFormul.CAS Number:10043353Title:SensitivityofFourNewZealandCladoceranSpecies andDaphniamagnatoAquaticToxicantsTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Ceriodaphnia dubia)MOR1. d TEC10: 130.4 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:130.4 g/m3Orig:g/m3<24 h NEWater FleaMORMORT FW(Ceriodaphnia pulchella)MOR1. d TEC10: 48.8 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:48.8 g/m3Orig:g/m3<24 h NEWater FleaMORMORT FW(Simocephalus vetulus)MOR1. d TEC10: 38.1 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:38.1 g/m3Orig:g/m3<24 h NEWater FleaMORMORT FW(Daphnia magna)MOR1. d TEC50: 319.8 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:319.8 g/m3Orig:g/m3<24 h NEWater FleaMORMORT FW(Simocephalus vetulus)MOR1. d TEC50: 123.4 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:123.4 g/m3Orig:g/m3<24 h NEWater FleaMORMORT FW(Daphnia carinata)MOR1. d TEC50: 267.7 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:267.7 g/m3Orig:g/m3<24 h NEWater FleaMORMORT FW(Ceriodaphnia pulchella)MOR1. d TEC50: 101.2 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:101.2 g/m3Orig:g/m3<24 h NEWater FleaMORMORT FW(Ceriodaphnia dubia)MOR1. d TEC50: 180.6 mg/LNR100 LAB S 7.9* 250* mg/LCaCO3Orig:180.6 g/m3Orig:g/m3<24 h NERef #11389Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Gersich FMTitle:Evaluation of a Static Renewal Chronic Toxicity Test Method for Daphnia magna Straus UsingBoric AcidYear:1984Source:Environ. Toxicol. Chem. 3(1): 89-94AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsMonday, June 15, 2015Page 14 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #11389Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Gersich FMTitle:Evaluation of a Static Renewal Chronic Toxicity Test Method for Daphnia magna Straus UsingBoric AcidYear:1984Source:Environ. Toxicol. Chem. 3(1): 89-94AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Daphnia magna)MOR2. d TLC50: 133 mg/LNR100 LAB S 6.7 to8.1148 mg/L CaCO3Orig:133000 ug/LOrig:ug/LNERef #19550Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Maier KJTitle:The Toxicity and Bioaccumulation of Selenium and Boron to Daphnia magna and ChironomusdecorusYear:1990Source:"Ph.D. Thesis, University of California, Davis,CA : 191 p."AgeLifestageFormul.CAS Number:1330434Test Chemical:Boron sodiumoxide (B4Na2O7)as Boron equivalentsMidgeMORMORT FW(Chironomus decorus)MOR2. d TLC50: 1376 mg/LNR100 LAB R 8.2 85 mg/L CaCO3Orig:1376 mg/LOrig:mg/L4 ins LVWater FleaMORMORT FW(Daphnia magna)MOR2. d TLC50: 141 mg/LNR100 LAB R 8.2 85 mg/L CaCO3Orig:141 mg/LOrig:mg/LNERef #111738Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Li E;Xiong Z;Chen L;Zeng C;Li KYear:2008Source:Aquaculture 278(1-4): 175-178AgeLifestageFormul.CAS Number:10043353Title:"AcuteToxicityofBoronto JuvenileWhiteShrimp, Litopenaeus vannamei, atTwoSalinities"Test Chemical:Boricacid (H3BO3)as Boron equivalentsWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR3. d TLC50: 54.43 mg/LNR1 100 LAB R 8.3NROrig:54.43 mg/LOrig:mg/LJVMonday, June 15, 2015Page 15 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #111738Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Li E;Xiong Z;Chen L;Zeng C;Li KYear:2008Source:Aquaculture 278(1-4): 175-178AgeLifestageFormul.CAS Number:10043353Title:"AcuteToxicityofBoronto JuvenileWhiteShrimp, Litopenaeus vannamei, atTwoSalinities"Test Chemical:Boricacid (H3BO3)as Boron equivalentsWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR3. dTLC50: 51.87 mg/LNR1 100 LAB R 8.3NROrig:51.87 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR4. dTLC50: 26.39 mg/LNR1 100 LAB R 8.3NROrig:26.39 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR3. dTLC50: 44.13 mg/LNR1 100 LAB R 8.3NROrig:44.13 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR4. dTLC50: 24.38 mg/LNR1 100 LAB R 8.3NROrig:24.38 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR1. dTLC50: 597.14 mg/LNR1 100 LAB R 8.3NROrig:597.14 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR1. dTLC50: 552.55 mg/LNR1 100 LAB R 8.3NROrig:552.55 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR1. dTLC50: 507.97 mg/LNR1 100 LAB R 8.3NROrig:507.97 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR2. dTLC50: 139.29 mg/LNR1 100 LAB R 8.3NROrig:139.29 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR2. dTLC50: 171.48 mg/LNR1 100 LAB R 8.3NROrig:171.48 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR2. dTLC50: 149.29 mg/LNR1 100 LAB R 8.3NROrig:149.29 mg/LOrig:mg/LJVWhite ShrimpMORMORT FW(Litopenaeus vannamei)MOR4. dTLC50: 24.38 mg/LNR1 100 LAB R 8.3NROrig:24.38 mg/LOrig:mg/LJVMonday, June 15, 2015Page 16 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #118810Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Dethloff GM;Stubblefield WA;Schlekat CEYear:2009Source:Arch. Environ. Contam. Toxicol. 57(1): 60-67AgeLifestageFormul.CAS Number:10043353Title:Effects ofWater QualityParameters onBoron ToxicitytoCeriodaphniadubiaTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 72.1 mg/LNR5 100 LAB S90 mg/L CaCO3Orig:72.1 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 60.9 mg/LNR5 100 LAB S90 mg/L CaCO3Orig:60.9 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 154.3 mg/LNR6 100 LAB S 7.6 112 mg/L CaCO3Orig:154.3 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 83.8 mg/LNR5 100 LAB S90 mg/L CaCO3Orig:83.8 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 45.5 mg/LNR5 100 LAB S96 mg/L CaCO3Orig:45.5 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 50.8 mg/LNR5 100 LAB S290 mg/L CaCO3Orig:50.8 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 50.6 mg/LNR5 100 LAB S168 mg/L CaCO3Orig:50.6 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 62.8 mg/LNR5 100 LAB S508 mg/L CaCO3Orig:62.8 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 99.4 mg/LNR5 100 LAB S 8.1 100 mg/L CaCO3Orig:99.4 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 62.4 mg/LNR5 100 LAB S 7.7 to8.1120 mg/L CaCO3Orig:62.4 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 79.7 mg/LNR5 100 LAB S 7.4 90 mg/L CaCO3Orig:79.7 mg/LOrig:mg/L<24 hMonday, June 15, 2015Page 17 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #118810Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Dethloff GM;Stubblefield WA;Schlekat CEYear:2009Source:Arch. Environ. Contam. Toxicol. 57(1): 60-67AgeLifestageFormul.CAS Number:10043353Title:Effects ofWater QualityParameters onBoron ToxicitytoCeriodaphniadubiaTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 107.8 mg/LNR6 100 LAB S 7.7 318 mg/L CaCO3Orig:107.8 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 78.8 mg/LNR5 100 LAB S90 mg/L CaCO3Orig:78.8 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 75.5 mg/LNR5 100 LAB S 7.7 to8.1120 mg/L CaCO3Orig:75.5 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 85.2 mg/LNR5 100 LAB S 7.7 to8.1120 mg/L CaCO3Orig:85.2 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 90.8 mg/LNR5 100 LAB S 7.7 to8.1120 mg/L CaCO3Orig:90.8 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 89.9 mg/LNR5 100 LAB S 7.7 to8.1120 mg/L CaCO3Orig:89.9 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 82.7 mg/LNR6 100 LAB S 7.2 166 mg/L CaCO3Orig:82.7 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 114.8 mg/LNR6 100 LAB S 7.2 166 mg/L CaCO3Orig:114.8 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 160.9 mg/LNR6 100 LAB S 7.7 318 mg/L CaCO3Orig:160.9 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 60.3 mg/LNR5 100 LAB S 7.1 100 mg/L CaCO3Orig:60.3 mg/LOrig:mg/L<24 hWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. dTLC50: 84.6 mg/LNR6 100 LAB S 7.6 112 mg/L CaCO3Orig:84.6 mg/LOrig:mg/L<24 hMonday, June 15, 2015Page 18 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #118810Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Dethloff GM;Stubblefield WA;Schlekat CEYear:2009Source:Arch. Environ. Contam. Toxicol. 57(1): 60-67AgeLifestageFormul.CAS Number:10043353Title:Effects ofWater QualityParameters onBoron ToxicitytoCeriodaphniadubiaTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Ceriodaphnia dubia)MOR2. d TLC50: 134.1 mg/LNR5 100 LAB S 8.4 90 mg/L CaCO3Orig:134.1 mg/LOrig:mg/L<24 hRef #151495Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Khangarot BS;Das STitle:"Acute Toxicity of Metals and Reference Toxicants to a Freshwater Ostracod, Cyprissubglobosa Sowerby, 1840 and Correlation to EC50 Values of Other Test Models"Year:2009Source:J. Hazard. Mater. 172(2/3): 641-649AgeLifestageFormul.CAS Number:1303964Test Chemical:Borax (B4Na2O7.10H2O)as Boron equivalentsOstracodPHYIMBL FW(Cypris subglobosa)ITX1. d TEC50: 2400 mg/LNR1>98 to 99.9LAB R 7.6(7.4 to245 (230 to 250)mg/L CaCO3Orig:2400 mg/LOrig:mg/LPUOstracod PHY IMBL FW(Cypris subglobosa)ITX 2.d TEC50: 1645 mg/LNR1>98 to 99.9LAB R 7.6(7.4 to245 (230 to 250)mg/L CaCO3Orig:1645 mg/LOrig:mg/LPUChronicRef #3474Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Gersich FM;Milazzo DPYear:1990Source:Arch. Environ. Contam. Toxicol. 19(1): 72-76AgeLifestageFormul.CAS Number:10043353Title:Evaluation ofa 14-DayStaticRenewal ToxicityTestwithDaphnia magna StrausTest Chemical:Boricacid (H3BO3)as a.e.Water FleaGROGGRO FW(Daphnia magna)GRO14. d TMATC: 19.7-20.3 mg/LNR99.5 LAB R 7.3 to8.2NROrig:Orig:ug/LNEPUMonday, June 15, 2015Page 19 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #3474Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Gersich FM;Milazzo DPYear:1990Source:Arch. Environ. Contam. Toxicol. 19(1): 72-76AgeLifestageFormul.CAS Number:10043353Title:Evaluation ofa 14-DayStaticRenewal ToxicityTestwithDaphnia magna StrausTest Chemical:Boricacid (H3BO3)as a.e.Water FleaMORMORT FW(Daphnia magna)MOR14. d TMATC: 19.7-20.3 mg/LNR99.5 LAB R 7.3 to8.2NROrig:Orig:ug/LNEPUWater FleaREPGREP FW(Daphnia magna)REP14. d TMATC: 19.7-20.3 mg/LNR99.5 LAB R 7.3 to8.2NROrig:Orig:ug/LNEPURef #4785Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Lewis MA;Valentine LCYear:1981Source:Bull. Environ. Contam. Toxicol. 27(3): 309-315AgeLifestageFormul.CAS Number:10043353Title:Acute and ChronicToxicitiesofBoric AcidtoDaphnia magna StrausTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Daphnia magna)MOR21. d TLC50: 53.2 mg/LNR100 LAB R 7.1 to8.7166 (135 to 217)mg/L CaCO3Orig:53200 ug/LOrig:ug/L<24 hWater FleaREPGREP FW(Daphnia magna)REP21. d TNOEC: 6 mg/LNR100 LAB R 7.1 to8.7166 (135 to 217)mg/L CaCO3Orig:6000 ug/LOrig:ug/L<24 hRef #8764Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hickey CWYear:1989Source:N. Z. J. Mar. Freshw. Res. 23(1): 131-137AgeLifestageFormul.CAS Number:10043353Title:SensitivityofFourNewZealandCladoceranSpecies andDaphniamagnatoAquaticToxicantsTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaREPPROG FW(Daphnia magna)REP14. d TLOEC: 32 mg/LNR100 LAB R 7.9* 250* mg/LCaCO3Orig:32 g/m3Orig:g/m3<24 h NEMonday, June 15, 2015Page 20 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #8764Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hickey CWYear:1989Source:N. Z. J. Mar. Freshw. Res. 23(1): 131-137AgeLifestageFormul.CAS Number:10043353Title:SensitivityofFourNewZealandCladoceranSpecies andDaphniamagnatoAquaticToxicantsTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaREPPROG FW(Ceriodaphnia dubia)REP14. d TLOEC: 18 mg/LNR100 LAB R 7.9* 250* mg/LCaCO3Orig:18 g/m3Orig:g/m3<24 h NEWater FleaREPPROG FW(Daphnia magna)REP14.d TMATC: 24 mg/LNR100 LAB R 7.9* 250* mg/LCaCO3Orig:24 g/m3Orig:g/m3<24 h NEWater FleaREPPROG FW(Ceriodaphnia dubia)REP14.d TMATC: 13.4 mg/LNR100 LAB R 7.9* 250* mg/LCaCO3Orig:13.4 g/m3Orig:g/m3<24 h NEWater FleaREPPROG FW(Daphnia magna)REP14.d TNOEC: 18 mg/LNR100 LAB R 7.9* 250* mg/LCaCO3Orig:18 g/m3Orig:g/m3<24 h NEWater FleaREPPROG FW(Ceriodaphnia dubia)REP14.d TNOEC: 10 mg/LNR100 LAB R 7.9* 250* mg/LCaCO3Orig:10 g/m3Orig:g/m3<24 h NERef #9314Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Gersich FM;Hopkins DL;Applegath SL;Mendoza CG;Milazzo DPYear:1985Source:"In: R.C.Bahner and D.J.Hansen (Eds.), Aquatic Toxicology and HazardAssessment, 8th Symposium, ASTMAgeLifestageFormul.CAS Number:10043353Title:TheSensitivityofChronic Endpoints Used inDaphniamagnaStraus Life-Cycle TestsTest Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaGROGGRO FW(Daphnia magna)GRO21. d TMATC: 9.33 mg/LNR99.5 LAB R 7.3 to8.1149 mg/L CaCO3Orig:9330 ug/LOrig:ug/LNEPUWater FleaREPGREP FW(Daphnia magna)REP21. d TMATC: 9.33 mg/LNR99.5 LAB R 7.3 to8.1149 mg/L CaCO3Orig:9330 ug/LOrig:ug/LNEPUMonday, June 15, 2015Page 21 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #11389Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Gersich FMTitle:Evaluation of a Static Renewal Chronic Toxicity Test Method for Daphnia magna Straus UsingBoric AcidYear:1984Source:Environ. Toxicol. Chem. 3(1): 89-94AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsWater FleaMORMORT FW(Daphnia magna)MOR21. d TLC50: 52.2 mg/LNR100 LAB R 6.7 to8.1148 mg/L CaCO3Orig:52200 ug/LOrig:ug/LNEWater FleaREPGREP FW(Daphnia magna)REP21. d TMATC: 9.33 mg/LNR100 LAB R 6.7 to8.1148 mg/L CaCO3Orig:9330 ug/LOrig:ug/LNEMarine/estuarine fishTaxa_Code:SWFAcuteRef #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalents"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. d TLC50: 178 mg/LNR1 100 LAB R 7.9 to8.1NROrig:178 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. d TLC50: >201 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>201 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. d TLC50: >262 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>262 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. d TLC50: 206 mg/LNR1 100 LAB R 7.9 to8.1NROrig:206 mg/LOrig:mg/LMonday, June 15, 2015Page 22 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalents"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >262 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>262 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >241 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>241 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >241 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>241 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 151 mg/LNR1 100 LAB R 7.9 to8.1NROrig:151 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: 158 mg/LNR1 100 LAB R 7.9 to8.1NROrig:158 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >373 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>373 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: 262 mg/LNR1 100 LAB R 7.9 to8.1NROrig:262 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 190 mg/LNR1 100 LAB R 7.9 to8.1NROrig:190 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: 144 mg/LNR1 100 LAB R 7.9 to8.1NROrig:144 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >188 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>188 mg/LOrig:mg/LMonday, June 15, 2015Page 23 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalents"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 108 mg/LNR1 100 LAB R 7.9 to8.1NROrig:108 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 350 mg/LNR1 100 LAB R 7.9 to8.1NROrig:350 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >163 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>163 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 113 mg/LNR1 100 LAB R 7.9 to8.1NROrig:113 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: 155 mg/LNR1 100 LAB R 7.9 to8.1NROrig:155 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >163 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>163 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 207 mg/LNR1 100 LAB R 7.9 to8.1NROrig:207 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: >392 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>392 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 108 mg/LNR1 100 LAB R 7.9 to8.1NROrig:108 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >392 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>392 mg/LOrig:mg/LMonday, June 15, 2015Page 24 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalents"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. d TLC50: >406 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>406 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. d TLC50: >241 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>241 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. d TLC50: >176 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>176 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. d TLC50: >259 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>259 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. d TLC50: >406 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>406 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. d TLC50: >176 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>176 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. d TLC50: >406 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>406 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. d TLC50: >188 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>188 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. d TLC50: >392 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>392 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. d TLC50: 178 mg/LNR1 100 LAB R 7.9 to8.1NROrig:178 mg/LOrig:mg/LMonday, June 15, 2015Page 25 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalents"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 153 mg/LNR1 100 LAB R 7.9 to8.1NROrig:153 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 252 mg/LNR1 100 LAB R 7.9 to8.1NROrig:252 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >201 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>201 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >328 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>328 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >373 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>373 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: >259 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>259 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: >182 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>182 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >182 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>182 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: 196 mg/LNR1 100 LAB R 7.9 to8.1NROrig:196 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >200 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>200 mg/LOrig:mg/LMonday, June 15, 2015Page 26 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalents"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >200 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>200 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. dTLC50: 320 mg/LNR1 100 LAB R 7.9 to8.1NROrig:320 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >259 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>259 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >259 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>259 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >182 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>182 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 299 mg/LNR1 100 LAB R 7.9 to8.1NROrig:299 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR4. dTLC50: 178 mg/LNR1 100 LAB R 7.9 to8.1NROrig:178 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR1. dTLC50: >196 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>196 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >196 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>196 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR2. dTLC50: >328 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>328 mg/LOrig:mg/LMonday, June 15, 2015Page 27 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalents"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. d TLC50: >373 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>373 mg/LOrig:mg/L"Hirame, Flounder"MORMORT SW(Paralichthys olivaceus)MOR3. d TLC50: >196 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>196 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. d TLC50: 127 mg/LNR1 100 LAB R 7.9 to8.1NROrig:127 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. d TLC50: >177 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>177 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. d TLC50: >212 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>212 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. d TLC50: 110 mg/LNR1 100 LAB R 7.9 to8.1NROrig:110 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. d TLC50: <110 mg/LNR1 100 LAB R 7.9 to8.1NROrig:<110 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. d TLC50: >161 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>161 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. d TLC50: >161 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>161 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. d TLC50: >161 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>161 mg/LOrig:mg/LMonday, June 15, 2015Page 28 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: 152 mg/LNR1 100 LAB R 7.9 to8.1NROrig:152 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 75 mg/LNR1 100 LAB R 7.9 to8.1NROrig:75 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >121 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>121 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >121 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>121 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: 94 mg/LNR1 100 LAB R 7.9 to8.1NROrig:94 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >218 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>218 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: >218 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>218 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >218 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>218 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >212 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>212 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: >212 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>212 mg/LOrig:mg/LMonday, June 15, 2015Page 29 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 193 mg/LNR1 100 LAB R 7.9 to8.1NROrig:193 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >132 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>132 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: >132 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>132 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 129 mg/LNR1 100 LAB R 7.9 to8.1NROrig:129 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 220 mg/LNR1 100 LAB R 7.9 to8.1NROrig:220 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: 175 mg/LNR1 100 LAB R 7.9 to8.1NROrig:175 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: >161 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>161 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 147 mg/LNR1 100 LAB R 7.9 to8.1NROrig:147 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >172 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>172 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >172 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>172 mg/LOrig:mg/LMonday, June 15, 2015Page 30 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 172 mg/LNR1 100 LAB R 7.9 to8.1NROrig:172 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: 207 mg/LNR1 100 LAB R 7.9 to8.1NROrig:207 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >141 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>141 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >257 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>257 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >161 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>161 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 145 mg/LNR1 100 LAB R 7.9 to8.1NROrig:145 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >257 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>257 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >252 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>252 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >252 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>252 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 169 mg/LNR1 100 LAB R 7.9 to8.1NROrig:169 mg/LOrig:mg/LMonday, June 15, 2015Page 31 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseFlounder Paralichthys olivaceus and Red Sea Bream Pagrus majorYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Test Chemical:Boricacid (H3BO3)as Boron equivalentsRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: >209 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>209 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >209 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>209 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >209 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>209 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 156 mg/LNR1 100 LAB R 7.9 to8.1NROrig:156 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: >172 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>172 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >132 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>132 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. dTLC50: >121 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>121 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR1. dTLC50: >161 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>161 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. dTLC50: 113 mg/LNR1 100 LAB R 7.9 to8.1NROrig:113 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. dTLC50: >121 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>121 mg/LOrig:mg/LMonday, June 15, 2015Page 32 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166696Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Furuta T;Iwata N;Kikuchi KTitle:Effects of Fish Size and Water Temperature on the Acute Toxicity of Boron to JapaneseYear:2007Source:Fish. Sci. 73(2): 356-363AgeLifestageFormul.CAS Number:10043353Flounder Paralichthys olivaceusand RedSeaBreamPagrus majorTest Chemical:Boricacid (H3BO3)as Boron equivalentsRed Sea BreamMORMORT SW(Pagrus major)MOR1. d TLC50: >121 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>121 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR4. d TLC50: 97 mg/LNR1 100 LAB R 7.9 to8.1NROrig:97 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR3. d TLC50: >141 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>141 mg/LOrig:mg/LRed Sea BreamMORMORT SW(Pagrus major)MOR2. d TLC50: >141 mg/LNR1 100 LAB R 7.9 to8.1NROrig:>141 mg/LOrig:mg/LChronicRef #451Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Thompson JAJ;Davis JC;Drew REYear:1976Source:Water Res. 10(10): 869-875AgeLifestageFormul.CAS Number:7775191Title:"Toxicity,Uptakeand SurveyStudies ofBoron in theMarineEnvironment"Test Chemical:"Boricacid (HBO2), sodiumsalt"expressed as Boron equivalentsSilver SalmonMORMORT SW(Oncorhynchus kisutch)MOR11.8 d TLC50: 12.2 mg/LNR100 LAB R 7.3(7.0 toNROrig:12200 ug/LOrig:ug/LUYMarine/estuarine crustaceansTaxa_Code:SWCRAcuteMonday, June 15, 2015Page 33 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #63149Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Marcussen CE;Yurk JJYear:1990Source:"Lab.Proj.ID No.3903004000-0215-3140,ESE, Gainesville, FL : 44 p."AgeLifestageFormul.CAS Number:10043353Title:Boron:AcuteToxicitytoMysids(Mysidopsisbahia) Under Flow-Through ConditionsTest Chemical:Boricacid (H3BO3)as Boron equivalentsOpossum ShrimpMORMORT SW(Americamysis bahia)MOR2. d TLC50: 92.83 mg/LNR98 LAB F 8.1(7.9 toNROrig:92.83 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR3. d TLC50: 93.31 mg/LNR98 LAB F 8.1(7.9 toNROrig:93.31 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR1. d TLC50: 147.65 mg/LNR98 LAB F 8.1(7.9 toNROrig:147.65 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR2. d TLC50: 89.07 mg/LNR98 LAB F 8.1(7.9 toNROrig:89.07 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR4. d TLC50: 84.39 mg/LNR98 LAB F 8.1(7.9 toNROrig:84.39 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR1. d TLC50: 164.31 mg/LNR98 LAB F 8.1(7.9 toNROrig:164.31 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR4. d TLC50: 83.56 mg/LNR98 LAB F 8.1(7.9 toNROrig:83.56 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR3. d TLC50: 73.79 mg/LNR98 LAB F 8.1(7.9 toNROrig:73.79 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR4. d TLC50: 93.31 mg/LNR98 LAB F 8.1(7.9 toNROrig:93.31 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR1. d TLC50: 148 mg/LNR98 LAB F 8.1(7.9 toNROrig:148 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR3. d TLC50: 84.39 mg/LNR98 LAB F 8.1(7.9 toNROrig:84.39 mg/LOrig:mg/L<24 h JVPUMonday, June 15, 2015Page 34 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #63149Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Marcussen CE;Yurk JJYear:1990Source:"Lab.Proj.ID No.3903004000-0215-3140,ESE, Gainesville, FL : 44 p."AgeLifestageFormul.CAS Number:10043353Title:Boron:AcuteToxicitytoMysids(Mysidopsisbahia) Under Flow-Through ConditionsTest Chemical:Boricacid (H3BO3)as Boron equivalentsOpossum ShrimpMORMORT SW(Americamysis bahia)MOR2. dTLC50: 84.28 mg/LNR98 LAB F 8.1(7.9 toNROrig:84.28 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR3. dTLC50: 83.56 mg/LNR98 LAB F 8.1(7.9 toNROrig:83.56 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR4. dTLC50: 73.79 mg/LNR98 LAB F 8.1(7.9 toNROrig:73.79 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR1. dTLC50: 148 mg/LNR98 LAB F 8.1(7.9 toNROrig:148 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR2. dTLC50: 137.99 mg/LNR98 LAB F 8.1(7.9 toNROrig:137.99 mg/LOrig:mg/L<24 h JVPUOpossum ShrimpMORMORT SW(Americamysis bahia)MOR4. dTNR-LETH: 148 mg/LNR98 LAB F 8.1(7.9 toNROrig:148 mg/LOrig:mg/L<24 h JVPURef #111738Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Li E;Xiong Z;Chen L;Zeng C;Li KYear:2008Source:Aquaculture 278(1-4): 175-178AgeLifestageFormul.CAS Number:10043353Title:"AcuteToxicityofBoronto JuvenileWhiteShrimp, Litopenaeus vannamei, atTwoSalinities"Test Chemical:Boricacid (H3BO3)as Boron equivalentsWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR4. dTLC50: 79.17 mg/LNR1 100 LAB R 8.3NROrig:79.17 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR1. dTLC50: 570.82 mg/LNR1 100 LAB R 8.3NROrig:570.82 mg/LOrig:mg/LJVMonday, June 15, 2015Page 35 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #111738Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Li E;Xiong Z;Chen L;Zeng C;Li KYear:2008Source:Aquaculture 278(1-4): 175-178AgeLifestageFormul.CAS Number:10043353Title:"AcuteToxicityofBoronto JuvenileWhiteShrimp, Litopenaeus vannamei, atTwoSalinities"Test Chemical:Boricacid (H3BO3)as Boron equivalentsWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR1. dTLC50: 611.79 mg/LNR1 100 LAB R 8.3NROrig:611.79 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR2. dTLC50: 231.82 mg/LNR1 100 LAB R 8.3NROrig:231.82 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR2. dTLC50: 231.82 mg/LNR1 100 LAB R 8.3NROrig:231.82 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR2. dTLC50: 194.94 mg/LNR1 100 LAB R 8.3NROrig:194.94 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR3. dTLC50: 147.74 mg/LNR1 100 LAB R 8.3NROrig:147.74 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR3. dTLC50: 142.7 mg/LNR1 100 LAB R 8.3NROrig:142.7 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR3. dTLC50: 152.95 mg/LNR1 100 LAB R 8.3NROrig:152.95 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR4. dTLC50: 79.17 mg/LNR1 100 LAB R 8.3NROrig:79.17 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR4. dTLC50: 87.85 mg/LNR1 100 LAB R 8.3NROrig:87.85 mg/LOrig:mg/LJVWhite ShrimpMORMORT SW(Litopenaeus vannamei)MOR1. dTLC50: 611.79 mg/LNR1 100 LAB R 8.3NROrig:611.79 mg/LOrig:mg/LJVMonday, June 15, 2015Page 36 of 36Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Table 2 for Aquatic Animal Studies (species not comparable)Boric Acid CaseCAS Number:10043353PC Code:Download Date:11/4/2014Other aquatic animalsTaxa_Code:OAAAcuteRef #62058Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Bantle JA;Finch RA;Fort DJ;Stover EL;Hull M;Kumsher-King M;Gaudet-Hull AMTitle:Phase III Interlaboratory Study of FETAX Part 3. FETAX Validation Using 12 Compounds withand Without an Exogenous Metabolic Activation SystemYear:1999Source:J. Appl. Toxicol. 19(6): 447-472AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)African Clawed FrogMORMORT FW(Xenopus laevis)MOR4. dTLC50: 1217 mg/LNR100 LAB SNROrig:1.22 mg/mlOrig:mg/mlEMAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR4. dTLC50: 1010 mg/LNR100 LAB SNROrig:1.01 mg/mlOrig:mg/mlEMAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR4. dTLC50: 1110 mg/LNR100 LAB SNROrig:1.11 mg/mlOrig:mg/mlEMAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR4. dTLC50: 1365 mg/LNR100 LAB SNROrig:1.36 mg/mlOrig:mg/mlEMAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR4. dTLC50: 1075 mg/LNR100 LAB SNROrig:1.08 mg/mlOrig:mg/mlEMAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR4. dTLC50: 1010 mg/LNR100 LAB SNROrig:1.01 mg/mlOrig:mg/mlEMAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR4. dTLC50: 420 mg/LNR100 LAB SNROrig:0.42 mg/mlOrig:mg/mlEMMonday, June 15, 2015Page 1 of 5Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #62058Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Bantle JA;Finch RA;Fort DJ;Stover EL;Hull M;Kumsher-King M;Gaudet-Hull AMTitle:Phase III Interlaboratory Study of FETAX Part 3. FETAX Validation Using 12 Compounds withand Without an Exogenous Metabolic Activation SystemYear:1999Source:J. Appl. Toxicol. 19(6): 447-472AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)African Clawed FrogMORMORT FW(Xenopus laevis)MOR4. d TLC50: 550 mg/LNR100 LAB SNROrig:0.55 mg/mlOrig:mg/mlEMAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR4. d TLC50: 1046 mg/LNR100 LAB SNROrig:1.05 mg/mlOrig:mg/mlEMRef #166577Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Fort DJ;Propst TL;Stover EL;Strong PL;Murray FJTitle:Adverse Reproductive and Developmental Effects in Xenopus from Insufficient BoronYear:1998Source:Biol. Trace Elem. Res. 66(1-3): 237-259AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)African Clawed FrogMORMORT FW(Xenopus laevis)MOR4. d TNR-ZERO: 5 mg/LNR2 100 LAB RNROrig:5000 ug/LOrig:ug/LEMAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR4. d TNR-ZERO: 5 mg/LNR2 100 LAB RNROrig:5000 ug/LOrig:ug/LEMChronicRef #62058Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Bantle JA;Finch RA;Fort DJ;Stover EL;Hull M;Kumsher-King M;Gaudet-Hull AMTitle:Phase III Interlaboratory Study of FETAX Part 3. FETAX Validation Using 12 Compounds withand Without an Exogenous Metabolic Activation SystemYear:1999Source:J. Appl. Toxicol. 19(6): 447-472AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)Monday, June 15, 2015Page 2 of 5Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #62058Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Bantle JA;Finch RA;Fort DJ;Stover EL;Hull M;Kumsher-King M;Gaudet-Hull AMTitle:Phase III Interlaboratory Study of FETAX Part 3. FETAX Validation Using 12 Compounds withand Without an Exogenous Metabolic Activation SystemYear:1999Source:J. Appl. Toxicol. 19(6): 447-472AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)African Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 462 mg/LNR100 LAB SNROrig:0.462 mg/mlOrig:mg/mlEMAfrican Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 525 mg/LNR100 LAB SNROrig:0.525 mg/mlOrig:mg/mlEMAfrican Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 548 mg/LNR100 LAB SNROrig:0.548 mg/mlOrig:mg/mlEMAfrican Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 175 mg/LNR100 LAB SNROrig:0.175 mg/mlOrig:mg/mlEMAfrican Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 226 mg/LNR100 LAB SNROrig:0.226 mg/mlOrig:mg/mlEMAfrican Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 520 mg/LNR100 LAB SNROrig:0.52 mg/mlOrig:mg/mlEMAfrican Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 270 mg/LNR100 LAB SNROrig:0.27 mg/mlOrig:mg/mlEMAfrican Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 166 mg/LNR100 LAB SNROrig:0.166 mg/mlOrig:mg/mlEMAfrican Clawed FrogGRODFRM FW(Xenopus laevis)DVP4. d TEC50: 240 mg/LNR100 LAB SNROrig:0.24 mg/mlOrig:mg/mlEMAfrican Clawed FrogGROLGTH FW(Xenopus laevis)GRO4. d TLOAEL: 400 mg/LNR100 LAB SNROrig:0.4 mg/mlOrig:mg/mlEMMonday, June 15, 2015Page 3 of 5Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #62058Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Bantle JA;Finch RA;Fort DJ;Stover EL;Hull M;Kumsher-King M;Gaudet-Hull AMTitle:Phase III Interlaboratory Study of FETAX Part 3. FETAX Validation Using 12 Compounds withand Without an Exogenous Metabolic Activation SystemYear:1999Source:J. Appl. Toxicol. 19(6): 447-472AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)African Clawed FrogGROLGTH FW(Xenopus laevis)GRO4. d TLOAEL: 100 mg/LNR100 LAB SNROrig:0.1 mg/mlOrig:mg/mlEMAfrican Clawed FrogGROLGTH FW(Xenopus laevis)GRO4. d TLOAEL: 400 mg/LNR100 LAB SNROrig:0.4 mg/mlOrig:mg/mlEMAfrican Clawed FrogGROLGTH FW(Xenopus laevis)GRO4. d TLOAEL: 400 mg/LNR100 LAB SNROrig:0.4 mg/mlOrig:mg/mlEMAfrican Clawed FrogGROLGTH FW(Xenopus laevis)GRO4. d TLOAEL: 250 mg/LNR100 LAB SNROrig:0.25 mg/mlOrig:mg/mlEMAfrican Clawed FrogGROLGTH FW(Xenopus laevis)GRO4. d TLOAEL: 100 mg/LNR100 LAB SNROrig:0.1 mg/mlOrig:mg/mlEMAfrican Clawed FrogGROLGTH FW(Xenopus laevis)GRO4. d TLOAEL: 250 mg/LNR100 LAB SNROrig:0.25 mg/mlOrig:mg/mlEMAfrican Clawed FrogGROLGTH FW(Xenopus laevis)GRO4. d TLOAEL: 15 mg/LNR100 LAB SNROrig:0.015 mg/mlOrig:mg/mlEMRef #66626Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Fort DJ;Stover EL;Bantle JA;Dumont JN;Finch RATitle:"Evaluation of a Reproductive Toxicity Assay Using Xenopus laevis: Boric Acid, Cadmium andEthylene Glycol Monomethyl Ether"Year:2001Source:J. Appl. Toxicol. 21: 41-52AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)Monday, June 15, 2015Page 4 of 5Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #66626Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Fort DJ;Stover EL;Bantle JA;Dumont JN;Finch RATitle:"Evaluation of a Reproductive Toxicity Assay Using Xenopus laevis: Boric Acid, Cadmium andEthylene Glycol Monomethyl Ether"Year:2001Source:J. Appl. Toxicol. 21: 41-52AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)African Clawed FrogGROABNM FW(Xenopus laevis)DVP30. d TNOAEL: 49.5 mg/LLOAEL: 99 mg/L6 99 LAB RNROrig:50 mg/LOrig:100 mg/LADPUAfrican Clawed FrogMORMORT FW(Xenopus laevis)MOR30. d TNOAEL: 495 mg/LNR6 99 LAB RNROrig:500 mg/LOrig:mg/LADPUAfrican Clawed FrogREPGMET FW(Xenopus laevis)REP30. d TNOAEL: 9.9 mg/LLOAEL: 49.5 mg/L6 99 LAB RNROrig:10 mg/LOrig:50 mg/LADPURef #166414Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hall S;Lockwood R;Harrass MCTitle:Application of a Unique Test Design to Determine the Chronic Toxicity of Boron to the AquaticWorm Lumbriculus variegatus and Fatmucket Mussel Lampsilis siliquoideaYear:2014Source:Arch. Environ. Contam. Toxicol. 66(1): 58-68AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)Lamp-MusselMORMORT FW(Lampsilis siliquoidea)MOR21. d TNR-LETH: 100 mg/LNR1 99.5 LAB R 6.82 to7.9389 to 108 mg/LCaCO3Orig:100 mg/LOrig:mg/L~3 mo JVPULamp-MusselMORMORT FW(Lampsilis siliquoidea)MOR21. d TNR-LETH: 100 mg/LNR1 99.5 LAB L 6.21 to7.6089 to 108 mg/LCaCO3Orig:100 mg/LOrig:mg/L~3 mo JVPULamp-MusselMORMORT FW(Lampsilis siliquoidea)MOR21. d TNR-ZERO: 10 mg/LNR1 99.5 LAB R 6.82 to7.9389 to 108 mg/LCaCO3Orig:10 mg/LOrig:mg/L~3 mo JVPUMonday, June 15, 2015Page 5 of 5Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Table 3 for Aquatic Animal Studies (endpoints not comparable)Boric Acid CaseCAS Number:10043353PC Code:Download Date:11/4/2014Freshwater fishTaxa_Code:FWFOtherRef #105984Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Rowe RI;Bouzan C;Nabili S;Eckhert CDTitle:The Response of Trout and Zebrafish Embryos to Low and High Boron Concentrations is UShapedYear:1998Source:Biol. Trace Elem. Res. 66(1-3): 261-270AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)Rainbow TroutMORSURV FW(Oncorhynchus mykiss)MORht TNOAEL: 100 umol/LNR5 99.5 LAB S 7.2 to7.4*NROrig:100 umol/LOrig:umol/L<1 dpf EGRef #161191Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Padilla S;Corum D;Padnos B;Hunter DL;Beam A;Houck KA;Sipes N;Kleinstreuer N;KnudsenT;Dix DJ;Reif DMTitle:Zebrafish Developmental Screening of the ToxCast Phase I Chemical LibraryYear:2012Source:Reprod. Toxicol. 33(2): 174-187AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)Zebra DanioNOCMULT FW(Danio rerio)NOC5. d TEC10: 30.91 uMNR1 100 LAB RNROrig:30.91 uMOrig:uM6 to 8hpfEMZebra DanioNOCMULT FW(Danio rerio)NOC5. d TEC50: 60.68 uMNR1 100 LAB RNROrig:60.68 uMOrig:uM6 to 8hpfEMMonday, June 15, 2015Page 1 of 6Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #166376Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Teixido E;Pique E;Gomez-Catalan J;Llobet JMTitle:Assessment of Developmental Delay in the Zebrafish Embryo Teratogenicity AssayYear:2013Source:Toxicol. In Vitro 27: 469-478AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)Zebra DanioBCMACHE FW(Danio rerio)ENZ2. d TEC10: 3.9 mMNR1 100 LAB R 7.4*NROrig:3.9 mMOrig:mM4 hpf EMZebra DanioBCMACHE FW(Danio rerio)ENZ2. d TLOAEL: 35.5 mMNR1 100 LAB R 7.4*NROrig:35.5 mMOrig:mM4 hpf EMZebra DanioBCMACHE FW(Danio rerio)ENZ2. d TNOAEL: 20-25 mMNR1 100 LAB R 7.4*NROrig:Orig:mM4 hpf EMZebra DanioGROLGTH FW(Danio rerio)MPH2. d TEC10: 26.4 mMNR1 100 LAB R 7.4*NROrig:26.4 mMOrig:mM4 hpf EMZebra DanioGROLGTH FW(Danio rerio)MPH2. d TLOAEL: 20-25 mMNR1 100 LAB R 7.4*NROrig:Orig:mM4 hpf EMZebra DanioGROLGTH FW(Danio rerio)MPH2. d TNOAEL: ~15 mMNR1 100 LAB R 7.4*NROrig:~15 mMOrig:mM4 hpf EMMarine/estuarine crustaceansTaxa_Code:SWCROtherRef #15285Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Robinson DJS;Perkins EJTitle:The Toxicity of Some Wood Pulp Effluent ConstituentsYear:1977Source:"Sci.Rep.No.74/1, Cumbria Sea Fish.Comm., The Courts, Carlisle, England : 22p."AgeLifestageFormul.CAS Number:1303964Test Chemical:Borax (B4Na2O7.10H2O)Monday, June 15, 2015Page 2 of 6Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #15285Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Robinson DJS;Perkins EJTitle:The Toxicity of Some Wood Pulp Effluent ConstituentsYear:1977Source:"Sci.Rep.No.74/1, Cumbria Sea Fish.Comm., The Courts, Carlisle, England : 22p."AgeLifestageFormul.CAS Number:1303964Test Chemical:Borax (B4Na2O7.10H2O)"Gribble, Aquatic Sowbug"MORMORT SW(Limnoria lignorum)~MO1. d TLC50: 250 mg/LNR100 LAB SNROrig:250000 ug/LOrig:ug/LMarine/estuarine mollusksTaxa_Code:SWMOOtherRef #15285Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Robinson DJS;Perkins EJTitle:The Toxicity of Some Wood Pulp Effluent ConstituentsYear:1977Source:"Sci.Rep.No.74/1, Cumbria Sea Fish.Comm., The Courts, Carlisle, England : 22p."AgeLifestageFormul.CAS Number:1303964Test Chemical:Borax (B4Na2O7.10H2O)"Sea Slug, Nudibranch"MORMORT SW(Onchidoris fusca)~MO1. d TLC50: >250 mg/LNR100 LAB SNROrig:>250000 ug/LOrig:ug/LOther aquatic animalsTaxa_Code:OAAOtherMonday, June 15, 2015Page 3 of 6Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #66626Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Fort DJ;Stover EL;Bantle JA;Dumont JN;Finch RATitle:"Evaluation of a Reproductive Toxicity Assay Using Xenopus laevis: Boric Acid, Cadmium andEthylene Glycol Monomethyl Ether"Year:2001Source:J. Appl. Toxicol. 21: 41-52AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)African Clawed FrogCELNCRO FW(Xenopus laevis)HIS30. d TNOAEL: 9.9 mg/LLOAEL: 49.5 mg/L6 99 LAB RNROrig:10 mg/LOrig:50 mg/LADPUAfrican Clawed FrogGROSMIX FW(Xenopus laevis)MPH30. d TNOAEL: 9.9 mg/LLOAEL: 49.5 mg/L6 99 LAB RNROrig:10 mg/LOrig:50 mg/LADPUAfrican Clawed FrogGROSMIX FW(Xenopus laevis)MPH30. d TNOAEL: 99 mg/LLOAEL: 495 mg/L6 99 LAB RNROrig:100 mg/LOrig:500 mg/LADPURef #105901Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Fort DJ;McLaughlin DW;Rogers RL;Buzzard BOTitle:Effect of Endocrine Disrupting Chemicals on Germinal Vesicle Breakdown in Xenopus In VitroYear:2002Source:Drug Chem. Toxicol. (N.Y.) 25(3): 293-308AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)African Clawed FrogCELDEGN FW(Xenopus laevis)HIS1. d TNOAEL: 100 mg/LNR100 LAB SNROrig:100 mg/LOrig:mg/L6 stg EMRef #166414Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hall S;Lockwood R;Harrass MCTitle:Application of a Unique Test Design to Determine the Chronic Toxicity of Boron to the AquaticWorm Lumbriculus variegatus and Fatmucket Mussel Lampsilis siliquoideaYear:2014Source:Arch. Environ. Contam. Toxicol. 66(1): 58-68AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)Monday, June 15, 2015Page 4 of 6Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.* Indicates that water quality parameters are for dilution water, not treatment water.Ref #166414Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hall S;Lockwood R;Harrass MCTitle:Application of a Unique Test Design to Determine the Chronic Toxicity of Boron to the AquaticWorm Lumbriculus variegatus and Fatmucket Mussel Lampsilis siliquoideaYear:2014Source:Arch. Environ. Contam. Toxicol. 66(1): 58-68AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)"Oligochaete, Worm"POPBMAS FW(Lumbriculus variegatus)POP28. d TIC25: 25.9 mg/LNR1 99.5 LAB L 5.88 to7.5189 to 108 mg/LCaCO3Orig:25.9 mg/LOrig:mg/LADPU"Oligochaete, Worm"POPBMAS FW(Lumbriculus variegatus)POP28.dTNOEC: 25 mg/LLOEC: 50 mg/L1 99.5 LAB L 5.88 to7.5189 to 108 mg/LCaCO3Orig:25 mg/LOrig:50 mg/LADPU"Oligochaete, Worm"POPPGRT FW(Lumbriculus variegatus)POP28.dTIC25: 12.7 mg/LNR1 99.5 LAB L 5.88 to7.5189 to 108 mg/LCaCO3Orig:12.7 mg/LOrig:mg/LADPU"Oligochaete, Worm"POPPGRT FW(Lumbriculus variegatus)POP28.dTNOEC: <=12.5 mg/LLOEC: 12.5 mg/L1 99.5 LAB L 5.88 to7.5189 to 108 mg/LCaCO3Orig:<=12.5 mg/LOrig:12 mg/LADPULamp-MusselGROLGTH FW(Lampsilis siliquoidea)MPH21.dTIC25: 34.6 mg/LNR1 99.5 LAB R 6.82 to7.9389 to 108 mg/LCaCO3Orig:34.6 mg/LOrig:mg/L~3 mo JVPULamp-MusselGROLGTH FW(Lampsilis siliquoidea)MPH21.dTIC25: 38.5 mg/LNR1 99.5 LAB L 6.21 to7.6089 to 108 mg/LCaCO3Orig:38.5 mg/LOrig:mg/L~3 mo JVPULamp-MusselGROLGTH FW(Lampsilis siliquoidea)MPH21.dTNOEC: 10 mg/LLOEC: 17.8 mg/L1 99.5 LAB R 6.82 to7.9389 to 108 mg/LCaCO3Orig:10 mg/LOrig:18 mg/L~3 mo JVPULamp-MusselGROLGTH FW(Lampsilis siliquoidea)MPH21.dTNOEC: 10 mg/LLOEC: 17.8 mg/L1 99.5 LAB L 6.21 to7.6089 to 108 mg/LCaCO3Orig:10 mg/LOrig:18 mg/L~3 mo JVPULamp-MusselMORSURV FW(Lampsilis siliquoidea)MOR21.dTIC25: 38.4 mg/LNR1 99.5 LAB R 6.82 to7.9389 to 108 mg/LCaCO3Orig:38.4 mg/LOrig:mg/L~3 mo JVPULamp-MusselMORSURV FW(Lampsilis siliquoidea)MOR21.dTIC25: 45 mg/LNR1 99.5 LAB L 6.21 to7.6089 to 108 mg/LCaCO3Orig:45 mg/LOrig:mg/L~3 mo JVPUMonday, June 15, 2015Page 5 of 6Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.Ref #166414Test SpeciesEffect Group Meas MediaEffectDurationTypeResults1Results2# of Levels % Purity Test Loc Exp Type pH HardnessAuthor:Hall S;Lockwood R;Harrass MCTitle:Application of a Unique Test Design to Determine the Chronic Toxicity of Boron to the AquaticWorm Lumbriculus variegatus and Fatmucket Mussel Lampsilis siliquoideaYear:2014Source:Arch. Environ. Contam. Toxicol. 66(1): 58-68AgeLifestageFormul.CAS Number:10043353Test Chemical:Boric acid (H3BO3)Lamp-MusselMORSURV FW(Lampsilis siliquoidea)MOR21. d TNOEC: 31.6 mg/LLOEC: 56.1 mg/L1 99.5 LAB L 6.21 to7.6089 to 108 mg/LCaCO3Orig:31.6 mg/LOrig:56 mg/L~3 mo JVPULamp-MusselMORSURV FW(Lampsilis siliquoidea)MOR21.dTNOEC: 31.6 mg/LLOEC: 56.1 mg/L1 99.5 LAB R 6.82 to7.9389 to 108 mg/LCaCO3Orig:31.6 mg/LOrig:56 mg/L~3 mo JVPUMonday, June 15, 2015Page 6 of 6Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.*Indicates that water quality parameters are for dilution water, not treatment water.

# Page 1 of 2

Monday, June 15, 2015 Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant. 

# Table 1 for Aquatic Plant Studies (comparable species and endpoints) CAS Number:



# Boric Acid Case PC Code:

Download Date : 11/4/2014

Ref # 2849 Author: De Jong LED Year: 1965

Title: Tolerance of Chlorella vulgaris for Metallic and Non

- Metallic Ions Source: Antonie van Leeuwenhoek (Gedrukt) 31: 301

- 313

Test Chemical : Sodium oxide CAS Number: 1330434

Common Name Formul. Effect Group Effect Meas Media Duration Type Age Lifestage Results 1 Results 2 # of Levels % Purity Test Loc Exp Type pH

Green Algae POP POP GPOP FW 3

- 4 MO T NOEC: 5.2 ppm LOEC: 10.4 ppm 100 LAB NR 2.2* to 8*

(Chlorella vulgaris) Orig 5200 ppb Orig 10400 ppb

Ref # 3493 Author: Wong PK;Wong CK Year: 1990

Title: Toxicity of Nickel and Nickel Electroplating Water to Chlorella pyrenoidosa Source: Bull. Environ. Contam. Toxicol. 45(5): 752

- 759

Test Chemical: Boric acid (H3BO3) CAS Number: 10043353

Common Name Formul. Effect Group Effect Meas Media Duration Type Age Lifestage Results 1 Results 2 # of Levels % Purity Test Loc Exp Type pH

Green Algae POP POP GPOP FW 14 d T NOEC: 0.4 ppm LOEC: 0.8 ppm 100 LAB S

(Chlorella pyrenoidosa ) Orig 4 00 ppb Orig 8 00 ppb

# Page 2 of 2

Monday, June 15, 2015 R esults in red indicate greater toxicity than most sensitive guideline study submitted by the registrant. Ref # 3493 Author: Hickey CW;Blaise C;Costan G Year: 1990

Title: Microtesting Appraisal of ATP and Cell Recovery Toxicity End Points After Acute Exposure

of Selenastrum capricornutum to Selected Chemicals Source: Environ. Toxicol. Water Qual. 6(4): 383

- 403

Test Chemical: Sodium oxide CAS Number: 1330434

Common Name Formul. Effect Group Effect Meas Media Duration Type Age Lifestage Results 1 Results 2 # of Levels % Purity Test Loc Exp Type pH

Green Algae POP POP PGRT FW 96 h T EC50 : 15.4 ppm 100 LAB S

( Pseudokirchneriella

subcapitata ) Or ig 15.4 PPMTable 1 for Terrestrial Animal Studies (comparable species and endpoints)Boric Acid CaseCAS Number:10043353PC Code:Download Date:11/4/2014BirdsTaxa_Code:BIRDAcuteRef #105865Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Sander JE;Dufour L;Wyatt RD;Bush PB;Page RKTitle:Acute Toxicity of Boric Acid and Boron Tissue Residues After Chronic Exposure in BroilerChickensYear:1991Source:Avian Dis. 35(4): 745-749Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenMORMORT NON(Gallus domesticus)MOR2. d TLD50: 2950 mg/kg bdwtNR8 100 LAB GVOrig2.95 g/kg bdwtOrigg/kg bdwt1 dPUDomestic ChickenMORMORT NON(Gallus domesticus)MOR2. dTNR-LETH: 5340 mg/kgNR8 100 LAB GVOrig5.34 g/kg bdwtOrigg/kg bdwt1 dPUDomestic ChickenMORMORT NON(Gallus domesticus)MOR2. dTNR-ZERO: 1550 mg/kgNR8 100 LAB GVOrig1.55 g/kg bdwtOrigg/kg bdwt1 dPUChronicRef #39727Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hoffman DJ;Camardese MB;LeCaptain LJ;Pendleton GWTitle:Effects of Boron on Growth and Physiology in Mallard DucklingsYear:1990Source:Environ. Toxicol. Chem. 9(3): 335-346Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckGROWGHT NON(Anas platyrhynchos)GRO70. d TNOAEL: 1750 ppmNR3 99 FIELDA FDOrig1750 ppmOrigppm1 dPOMonday, June 15, 2015Page 1 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #39727Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hoffman DJ;Camardese MB;LeCaptain LJ;Pendleton GWTitle:Effects of Boron on Growth and Physiology in Mallard DucklingsYear:1990Source:Environ. Toxicol. Chem. 9(3): 335-346Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckGROWGHT NON(Anas platyrhynchos)GRO70. d TNOAEL: 430 ppmLOAEL: 1750 ppm3 99 FIELDA FDOrig430 ppmOrig1750 ppm1 dPORef #39733Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hoffman DJ;Sanderson CJ;LeCaptain LJ;Cromartie E;Pendleton GWTitle:"Interactive Effects of Boron, Selenium, and Dietary Protein on Survival, Growth, and Physiologyin Mallard Ducklings"Year:1991Source:Arch. Environ. Contam. Toxicol. 20(2): 288-294Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckGROWGHT NON(Anas platyrhynchos)GRO28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckMORMORT NON(Anas platyrhynchos)MOR28. d TNR-ZERO: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPORef #39893Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Stanley TR;Jr;Smith GJ;Hoffman DJ;Heinz GH;Rosscoe RTitle:Effects of Boron and Selenium on Mallard Reproduction and Duckling Growth and SurvivalYear:1996Source:Environ. Toxicol. Chem. 15(7): 1124-1132Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckMORMORT NON(Anas platyrhynchos)MOR168. d TNR-ZERO: 900 ppmNR2 99.9 FIELDA FDOrig900 ppmOrigppm1 yrPUMonday, June 15, 2015Page 2 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #79568Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rennie JS;Whitehead CC;Montanari ATitle:Effects of Dietary Borate and Aluminate on Riboflavin Metabolism in the Breeding HenYear:1990Source:Res. Vet. Sci. 49(2): 253-255Test Chemical:"Boric acid (HBO2), sodium salt"CAS Number:7775191Lifestage:AgeFormul.Domestic ChickenREPPROG NON(Gallus domesticus)REP7. d TLOAEL: 15000 ppmNR1 100 LAB FDOrig15 g/kgOrigg/kgRef #105868Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dufour L;Sander JE;Wyatt RD;Rowland GN;Page RKTitle:Experimental Exposure of Broiler Chickens to Boric Acid to Assess Clinical Signs and Lesions ofToxicosisYear:1992Source:Avian Dis. 36(4): 1007-1011Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenGROWGHT NON(Gallus domesticus)GRO14. d TNOAEL: 1250 ppmLOAEL: 2500 ppm4 100 LAB FDOrig1250 ppmOrig2500 ppm1 dPUDomestic ChickenGROWGHT LIT(Gallus domesticus)GRO15. d TNOAEL: 0.9 kg/9.3 m2LOAEL: 3.6 kg/9.3 m2 3 100 LAB ENOrig0.9 kg/9.3 m2Orig4 kg/9.3 m21 dPUDomestic Chicken MOR MORT NON(Gallus domesticus)MOR 14. d TNOAEL: 2500 ppmLOAEL: 5000 ppm4 100 LAB FDOrig2500 ppmOrig5000 ppm1 dPUDomestic ChickenMORMORT NON(Gallus domesticus)MOR14. d TNR-ZERO: 500 ppmNR4 100 LAB FDOrig500 ppmOrigppm1 dPURef #111573Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yeslibag D;Eren MTitle:"Effects of Dietary Boric Acid Supplementation on Performance, Eggshell Quality and SomeSerum Parameters in Aged Laying Hens"Year:2008Source:Turk. J. Vet. Anim. Sci. 32(2): 113-117Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 3 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #111573Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yeslibag D;Eren MTitle:"Effects of Dietary Boric Acid Supplementation on Performance, Eggshell Quality and SomeSerum Parameters in Aged Laying Hens"Year:2008Source:Turk. J. Vet. Anim. Sci. 32(2): 113-117Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenREPPROG NR(Gallus domesticus)REP75. d TNOAEL: 100 ppmNR1 99.995 LAB FDOrig100 mg/kgOrigmg/kg60 dPURef #111574Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Olgun O;Cufadar Y;Yildiz AOTitle:Effects of Boron Supplementation Fed with Low Calcium to Diet on Performance and Egg Qualityin Molted Laying HensYear:2008Source:J. Anim. Vet. Adv. 8(4): 650-654Test Chemical:Boron sodium oxide (B4Na2O7)CAS Number:1330434Lifestage:AgeFormul.Domestic ChickenGROWGHT NON(Gallus domesticus)GRO84. d TNOAEL: 300 ppmNR1 100 LAB FDOrig300 mg/kg dietOrigmg/kg diet78 wkPODomestic ChickenREPPROG NON(Gallus domesticus)REP84. d TNOAEL: 300 ppmNR1 100 LAB FDOrig300 mg/kg dietOrigmg/kg diet78 wkPORef #166581Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eren M;Uyanik F;Kucukersan STitle:"The Influence of Dietary Boron Supplementation on Egg Quality and Serum Calcium, InorganicPhosphorus, Magnesium Levels and Alkaline Phosphatase Activity in Laying Hens"Year:2004Source:Res. Vet. Sci. 76(3): 203-210Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenGROWGHT NON(Gallus domesticus)GRO56. d TNOAEL: 200 ppmLOAEL: 400 ppm1 100 LAB FDOrig200 mg/kg dietOrig400 mg/kg diet136 dDomestic ChickenREPPROG NON(Gallus domesticus)REP<=56. d TNOAEL: 400 ppmNR1 100 LAB FDOrig400 mg/kg dietOrigmg/kg diet136 dMonday, June 15, 2015Page 4 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.RodentTaxa_Code:RODChronicRef #36437Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dixon RL;Sherins RJ;Lee IPTitle:Assessment of Environmental Factors Affecting Male FertilityYear:1979Source:Environ. Health Perspect. 30: 53-68Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO60. d TNOAEL: 2000 ppmNR3 100 LAB FDOrig2000 ppmOrigppmNorway RatREPFERT NON(Rattus norvegicus)REP37. d TNOAEL: 500 ppmLOAEL: 1000 ppm3 100 LAB FDOrig500 ppmOrig1000 ppmRef #48743Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dixon RL;Lee IP;Sherins RJTitle:Methods to Assess Reproductive Effects of Environmental Chemicals: Studies of Cadmium andBoron Administered OrallyYear:1976Source:Environ. Health Perspect. 13: 59-67Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO90. d TNOAEL: 6 ppmNR3 100 LAB DROrig6 mg/LOrigmg/LADNorway RatREPFERT NON(Rattus norvegicus)REP<70. d TNOAEL: 450 ppmNR3 100 LAB DTOrig450 mg/kgOrigmg/kgADMonday, June 15, 2015Page 5 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #72114Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:National Toxicology Program (NTP)Title:Toxicology and Carcinogenesis Studies of Boric Acid (CAS No.10043-35-3) in B6C3F1 Mice(Feed Studies)Year:1987Source:"NTP Rep.No.TR324, NIH Publ.No.88-2580, U.S.Dep.of Health and Hum.Serv.,Washington, DC : 126 p."Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseMORMORT NON(Mus musculus)MOR14. d TNR-ZERO: 9770.6 ppmNR5 99.7 LAB FDOrig9800 ppmOrigppm6 to 8 wkPUHouse MouseMORMORT NON(Mus musculus)MOR14. dTNR-ZERO: 9770.6 ppmNR5 99.7 LAB FDOrig9800 ppmOrigppm6 to 8 wkPURef #92705Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Strong PL;Marr MC;Myers CB;Murray FJTitle:Developmental Toxicity NOAEL and Postnatal Recovery in Rats fed Boric Acid During GestationYear:1996Source:Fundam. Appl. Toxicol. 32(2): 179-193Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGRODFRM NON(Rattus norvegicus)DVP20. d TNOEL: 54.55 ppmLOEL: 75.141 ppm1 99 LAB FDOrig55.1 mg/kg/dOrig76 mg/kg/dGE8 wkPUNorway RatGRODFRM NON(Rattus norvegicus)DVP41. dTNOEL: 75.14 ppmLOEL: 141.471 ppm 1 99 LAB FDOrig75.9 mg/kg/dOrig143 mg/kg/dGE8 wkPUNorway Rat GRO GAIN NON(Rattus norvegicus)GRO 20. dTNOAEL: 141.47 ppmNR1 99 LAB FDOrig142.9 mg/kg/dOrigmg/kg/dGE8 wkPUNorway RatGROWGHT NON(Rattus norvegicus)GRO20. dTNOEL: 54.55 ppmLOEL: 75.141 ppm1 99 LAB FDOrig55.1 mg/kg/dOrig76 mg/kg/dGE8 wkPUNorway RatGROWGHT NON(Rattus norvegicus)GRO20. dTNOEL: 54.55 ppmLOEL: 75.141 ppm1 99 LAB FDOrig55.1 mg/kg/dOrig76 mg/kg/dGE8 wkPUNorway RatMORMORT NON(Rattus norvegicus)MOR20. dTNOAEL: 141.47 ppmNR1 99 LAB FDOrig142.9 mg/kg/dOrigmg/kg/dGE8 wkPUMonday, June 15, 2015Page 6 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #92705Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Strong PL;Marr MC;Myers CB;Murray FJTitle:Developmental Toxicity NOAEL and Postnatal Recovery in Rats fed Boric Acid During GestationYear:1996Source:Fundam. Appl. Toxicol. 32(2): 179-193Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatMORMORT NON(Rattus norvegicus)MOR20. d TNR-ZERO: 141.47 ppmNR1 99 LAB FDOrig142.9 mg/kg/dOrigmg/kg/dGE8 wkPUNorway RatREPPREG NON(Rattus norvegicus)REP20. d TNOAEL: 141.47 ppmNR1 99 LAB FDOrig142.9 mg/kg/dOrigmg/kg/dGE8 wkPURef #105240Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Weir RJ;Jr;Fisher RSTitle:Toxicologic Studies on Borax and Boric AcidYear:1972Source:Toxicol. Appl. Pharmacol. 23: 351-364Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO90. d TLOAEL: 1750 ppmNR5 100 LAB FDOrig1750 ppmOrigppmYONorway RatGROWGHT NON(Rattus norvegicus)GRO90. d TLOAEL: 1750 ppmNR5 100 LAB FDOrig1750 ppmOrigppmYONorway RatGROWGHT NON(Rattus norvegicus)GRO90. d TLOAEL: 1750 ppmNR5 100 LAB FDOrig1750 ppmOrigppmYONorway RatGROWGHT NON(Rattus norvegicus)GRO90. d TLOAEL: 1750 ppmNR5 100 LAB FDOrig1750 ppmOrigppmYONorway RatMORMORT NON(Rattus norvegicus)MOR90. d TNR-LETH: 5250 ppmNR5 100 LAB FDOrig5250 ppmOrigppmYONorway RatMORMORT NON(Rattus norvegicus)MOR90. d TNR-LETH: 5250 ppmNR5 100 LAB FDOrig5250 ppmOrigppmYOMonday, June 15, 2015Page 7 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105240Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Weir RJ;Jr;Fisher RSTitle:Toxicologic Studies on Borax and Boric AcidYear:1972Source:Toxicol. Appl. Pharmacol. 23: 351-364Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatREPLIDX NON(Rattus norvegicus)REP~147. d TNOAEL: 117 ppmLOAEL: 350 ppm3 100 LAB FDOrig117 ppmOrig350 ppmNorway RatREPLIDX NON(Rattus norvegicus)REP~147. d TNOAEL: 117 ppmLOAEL: 350 ppm3 100 LAB FDOrig117 ppmOrig350 ppmRef #105510Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Lee IP;Sherins RJ;Dixon RLTitle:Evidence for Induction of Germinal Aplasia in Male Rats by Environmental Exposure to BoronYear:1978Source:Toxicol. Appl. Pharmacol. 45: 577-590Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO60. d TNOAEL: 2000 ppmNR3 100 LAB FDOrig2000 ppmOrigppmADNorway RatREPPREG NON(Rattus norvegicus)REP37. d TNOAEL: 500 ppmLOAEL: 1000 ppm3 100 LAB FDOrig500 ppmOrig1000 ppmADRef #105864Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Linder RE;Strader LF;Rehnberg GLTitle:Effect of Acute Exposure to Boric Acid on the Male Reproductive System of the RatYear:1990Source:J. Toxicol. Environ. Health 31: 133-146Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROGAIN NON(Rattus norvegicus)GRO2. d TLOAEL: 1980 mg/kg bdNR1 99 LAB GVOrig2000 mg/kgOrigmg/kgAD105 dPUMonday, June 15, 2015Page 8 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105864Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Linder RE;Strader LF;Rehnberg GLTitle:Effect of Acute Exposure to Boric Acid on the Male Reproductive System of the RatYear:1990Source:J. Toxicol. Environ. Health 31: 133-146Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO14. d TNOAEL: 1980 mg/kg bdNR4 99 LAB GVOrig2000 mg/kgOrigmg/kgAD105 dPUNorway RatREPSPCL NON(Rattus norvegicus)REP2. d TLOAEL: 1980 mg/kg bdNR1 99 LAB GVOrig2000 mg/kgOrigmg/kgAD105 dPUNorway RatREPSPCL NON(Rattus norvegicus)REP14. d TNOAEL: 495 mg/kg bdLOAEL: 990 mg/kg bd 4 99 LAB GVOrig500 mg/kgOrig1000 mg/kgAD105 dPURef #105885Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dieter MPTitle:Toxicity and Carcinogenicity Studies of Boric Acid in Male and Female B6C3F1 MiceYear:1994Source:Environ. Health Perspect. 102(suppl.7): 93-97Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseMORMORT NON(Mus musculus)MOR14. d TNR-LETH: 9.97 %NR5 99.7 LAB FDOrig10 %Orig%7 to 9 wkPUHouse MouseMORMORT NON(Mus musculus)MOR14. d TNR-ZERO: 1.25 %NR5 99.7 LAB FDOrig1.25 %Orig%7 to 9 wkPUHouse MouseMORMORT NON(Mus musculus)MOR14. d TNR-ZERO: 4.99 %NR5 99.7 LAB FDOrig5 %Orig%7 to 9 wkPUHouse MouseMORMORT NON(Mus musculus)MOR91. d TNR-ZERO: 0.997 %NR5 99.7 LAB FDOrig1 %Orig%7 to 9 wkPUHouse MouseMORMORT NON(Mus musculus)MOR91. d TNR-ZERO: 0.498 %NR5 99.7 LAB FDOrig0.5 %Orig%7 to 9 wkPUMonday, June 15, 2015Page 9 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105886Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fail PA;George JD;Seely JC;Grizzle TB;Heindel JJTitle:Reproductive Toxicity of Boric Acid in Swiss (CD-1) Mice: Assessment Using the ContinuousBreeding ProtocolYear:1991Source:Fundam. Appl. Toxicol. 17: 225-239Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGROWGHT NON(Mus musculus)GRO<=189. d TLOAEL: 837.54 ppmNR3 >99 LAB FDOrig846 mg/kg bdwtOrigmg/kg bdwtGE11 wkPUHouse MouseGROWGHT NON(Mus musculus)DVP189. d TNOAEL: 180.18 ppmLOAEL: 837.54 ppm 3 >99 LAB FDOrig182 mg/kg bdwtOrig846 mg/kg bdwGE11 wkPUHouse Mouse GRO WGHT NON(Mus musculus)GRO 189. d TNOAEL: 592.02 ppmLOAEL: 1247.4 ppm 3 >99 LAB FDOrig598 mg/kg bdwtOrig1260 mg/kg bdGE11 wkPUHouse Mouse REP MOTL NON(Mus musculus)REP 189. d TLOAEL: 108.9 ppmNR3 >99 LAB FDOrig110 mg/kg bdwtOrigmg/kg bdwtGE11 wkPUHouse MouseREPPROG NON(Mus musculus)REP~21. d TNOAEL: 180.18 ppmLOAEL: 837.54 ppm 3 >99 LAB FDOrig182 mg/kg bdwtOrig846 mg/kg bdwGE11 wkPURef #105887Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Heindel JJ;Price CJ;Field EA;Marr MC;Myers CB;Morrisey RE;Schwetz BATitle:Developmental Toxicity of Boric Acid in Mice and RatsYear:1992Source:Fundam. Appl. Toxicol. 18: 266-277Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGRODVLP NON(Mus musculus)DVP17. d TNOEL: 243.04 ppmLOEL: 442.96 ppm3 98 to 99 LAB FDOrig248 mg/kg/dOrig452 mg/kg/dGEPUHouse MouseGROWGHT NON(Mus musculus)GRO17. dTNOAEL: 442.96 ppmLOAEL: 982.94 ppm 3 98 to 99 LAB FDOrig452 mg/kg/dOrig1003 mg/kg/dGEPUHouse Mouse GRO WGHT NON(Mus musculus)DVP 17. dTNOAEL: 243.04 ppmLOAEL: 442.96 ppm 3 98 to 99 LAB FDOrig248 mg/kg/dOrig452 mg/kg/dGEPUMonday, June 15, 2015Page 10 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105887Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Heindel JJ;Price CJ;Field EA;Marr MC;Myers CB;Morrisey RE;Schwetz BATitle:Developmental Toxicity of Boric Acid in Mice and RatsYear:1992Source:Fundam. Appl. Toxicol. 18: 266-277Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseMORMORT NON(Mus musculus)MOR17. d TNR-ZERO: 982.94 ppmNR3 98 to 99 LAB FDOrig1003 mg/kg/dOrigmg/kg/dGEPUHouse MouseREPRSEM NON(Mus musculus)REP17. d TNOAEL: 442.96 ppmLOAEL: 982.94 ppm 3 98 to 99 LAB FDOrig452 mg/kg/dOrig1003 mg/kg/dGEPUNorway Rat GRO GAIN NON(Rattus norvegicus)GRO 14. d TLOAEL: 528.22 ppmNR1 98 to 99 LAB FDOrig539 mg/kg/dOrigmg/kg/dGEPUNorway RatGROGAIN NON(Rattus norvegicus)GRO20. d TNOAEL: 159.74 ppmLOAEL: 323.4 ppm3 98 to 99 LAB FDOrig163 mg/kg/dOrig330 mg/kg/dGEPUNorway RatGROWGHT NON(Rattus norvegicus)DVP14. d TLOAEL: 528.22 ppmNR1 98 to 99 LAB FDOrig539 mg/kg/dOrigmg/kg/dGEPUNorway RatGROWGHT NON(Rattus norvegicus)DVP20. d TLOAEL: 76.44 ppmNR3 98 to 99 LAB FDOrig78 mg/kg/dOrigmg/kg/dGEPUNorway RatMORMORT NON(Rattus norvegicus)MOR20. d TNR-ZERO: 323.4 ppmNR3 98 to 99 LAB FDOrig330 mg/kg/dOrigmg/kg/dGEPUNorway RatMORMORT NON(Rattus norvegicus)MOR14. d TNR-ZERO: 528.22 ppmNR1 98 to 99 LAB FDOrig539 mg/kg/dOrigmg/kg/dGEPUNorway RatREPRSEM NON(Rattus norvegicus)REP14. d TLOAEL: 528.22 ppmNR1 98 to 99 LAB FDOrig539 mg/kg/dOrigmg/kg/dGEPUNorway RatREPRSEM NON(Rattus norvegicus)REP20. d TNOAEL: 323.4 ppmNR3 98 to 99 LAB FDOrig330 mg/kg/dOrigmg/kg/dGEPUMonday, June 15, 2015Page 11 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105889Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ku WW;Chapin RETitle:Mechanism of the Testicular Toxicity of Boric Acid in Rats: In Vivo and In Vitro StudiesYear:1994Source:Environ. Health Perspect. 102(suppl.7): 99-105Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatREPSPMC NON(Rattus norvegicus)REP21. d TLOAEL: ~68 ppmNR1 100 LAB FDOrig~68 mg/kg bdwt/dOrigmg/kg bdwt/dADRef #105890Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Treinen KA;Chapin RETitle:Development of Testicular Lesions in F344 Rats After Treatment with Boric AcidYear:1991Source:Toxicol. Appl. Pharmacol. 107: 325-335Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO28. d TLOAEL: 348.3 ppmNR1 100 LAB FDOrig348.3 mg/kg/dOrigmg/kg/dAD120 dRef #105891Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Harris MW;Chapin RE;Lockhart AC;Jokinen MPTitle:Assessment of a Short-Term Reproductive and Developmental Toxicity ScreenYear:1992Source:Fundam. Appl. Toxicol. 19(2): 186-196Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseREPPREG NON(Mus musculus)REP21. d TNOAEL: 1200 mg/kg bdNR3 100 LAB GVOrig1200 mg/kg/dOrigmg/kg/d14 to 16wkHouse MouseREPPROG NON(Mus musculus)REP12. d TNOAEL: 400 mg/kg bdLOAEL: 1200 mg/kg b 3 100 LAB GVOrig400 mg/kg/dOrig1200 mg/kg/dGE14 to 16wkHouse Mouse REP SPCL NON(Mus musculus)REP 19. d TNOAEL: 1200 mg/kg bdNR3 100 LAB GVOrig1200 mg/kg/dOrigmg/kg/d14 to 16wkMonday, June 15, 2015Page 12 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105894Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Seaborn CD;Nielsen FHTitle:"Boron and Silicon: Effects on Growth, Plasma Lipids, Urinary Cyclic AMP and Bone and BrainMineral Composition of Male Rats"Year:1994Source:Environ. Toxicol. Chem. 13(6): 941-947Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO63. d TLOAEL: 500 ppmNR1 100 LAB FDOrig500 ug/g dietOrigug/g dietJVRef #105926Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Field EA;Marr MC;Myers CBTitle:Final Report on the Developmental Toxicity of Boric Acid (CAS No. 10043-35-3) in SpragueDawley RatsYear:1990Source:NTP-90-155 : 252 p.Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROABNM NON(Rattus norvegicus)DVP20. d TNOAEL: 0.392 %LOAEL: 0.784 %5 98 to 99 LAB FDOrig0.4 %Orig1 %Norway RatGROWGHT NON(Rattus norvegicus)GRO3. d TNOAEL: 1.18 %LOAEL: 2.352 %5 98 to 99 LAB FDOrig1.2 %Orig2 %Norway RatMORMORT NON(Rattus norvegicus)MOR20. d TNR-ZERO: 2.35 %NR5 98 to 99 LAB FDOrig2.4 %Orig%Norway RatREPRSEM NON(Rattus norvegicus)REP20. d TNOAEL: 0.392 %LOAEL: 0.784 %5 98 to 99 LAB FDOrig0.4 %Orig1 %Ref #105927Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Field EA;Price CJ;Marr MC;Myers CBTitle:Developmental Toxicity Evaluation of Boric Acid (CAS No. 10043-35-3) Administered in Feed toCD-1 Mice on Gestational Days 0 to 17Year:1989Source:"NTP NIH Publ.No.89-250, National Inst.of Health, Res.Triangle Park, NC : 400p."Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 13 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105927Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Field EA;Price CJ;Marr MC;Myers CBTitle:Developmental Toxicity Evaluation of Boric Acid (CAS No. 10043-35-3) Administered in Feed toCD-1 Mice on Gestational Days 0 to 17Year:1989Source:"NTP NIH Publ.No.89-250, National Inst.of Health, Res.Triangle Park, NC : 400p."Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGRODVLP NON(Mus musculus)DVP17. d TNOEL: 243.04 ppmLOEL: 442.96 ppm3 98 to 99 LAB FDOrig248 mg/kg/dOrig452 mg/kg/dGEPUHouse MouseGROGAIN NON(Mus musculus)GRO17. d TNOAEL: 0.196 %LOAEL: 0.392 %5 98 to 99 LAB FDOrig0.2 %Orig0 %GEPUHouse MouseGROWGHT NON(Mus musculus)DVP17. d TLOAEL: 0.196 %NR5 98 to 99 LAB FDOrig0.2 %Orig%GEPUHouse MouseGROWGHT NON(Mus musculus)GRO12. d TNOAEL: 442.96 ppmLOAEL: 982.94 ppm 3 98 to 99 LAB FDOrig452 mg/kg/dOrig1003 mg/kg/dGEPUHouse Mouse MOR MORT NON(Mus musculus)MOR 17. d TLD10: 0.833 %NR5 98 to 99 LAB FDOrig0.85 %Orig%GEPUHouse MouseMORMORT NON(Mus musculus)MOR17. d TNR-ZERO: 982.94 ppmNR3 98 to 99 LAB FDOrig1003 mg/kg/dOrigmg/kg/dGEPUHouse MouseMORMORT NON(Mus musculus)MOR17. d TNR-ZERO: 0.784 %NR5 98 to 99 LAB FDOrig0.8 %Orig%GEPUHouse MouseREPRSEM NON(Mus musculus)REP17. d TNOAEL: 442.96 ppmLOAEL: 982.94 ppm 3 98 to 99 LAB FDOrig452 mg/kg/dOrig1003 mg/kg/dGEPUHouse Mouse REP RSEM NON(Mus musculus)REP 17. d TNOAEL: 0.392 %LOAEL: 0.784 %5 98 to 99 LAB FDOrig0.4 %Orig1 %GEPUMonday, June 15, 2015Page 14 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105930Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Marr MC;Myers CB;Shelby MD;Schwetz BATitle:"Final Report on the CNS Developmental Toxicity of Boric Acid (CAS No. 10043-35-3) inSprague-Dawley CD Rats Exposed on Gestation Days 6-15. Volume 1 of 2, Volume 2 of 2,Laboratory Supplement"Year:1994Source:"TER 93138, Research Triangle Inst., National Toxicology Program, NationalInst.Environ.Health Sci,Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGRODFRM NR(Rattus norvegicus)DVP14. d TLOAEL: 52 ppmNR4 99 LAB FDOrig52 mg/kg/dOrigmg/kg/dGE9 wkPUNorway RatGROWGHT NR(Rattus norvegicus)GRO9. d TLOAEL: 52 ppmNR4 99 LAB FDOrig52 mg/kg/dOrigmg/kg/dGE9 wkPUNorway RatGROWGHT NR(Rattus norvegicus)GRO14. d TLOAEL: 52 ppmNR4 99 LAB FDOrig52 mg/kg/dOrigmg/kg/dGE9 wkPUNorway RatGROWGHT NR(Rattus norvegicus)GRO14. d TLOAEL: 52 ppmNR4 99 LAB FDOrig52 mg/kg/dOrigmg/kg/dGE9 wkPUNorway RatMORMORT NR(Rattus norvegicus)MOR14. d TNOAEL: 63 ppmLOAEL: 76 ppm4 99 LAB FDOrig63 mg/kg/dOrig76 mg/kg/dGE9 wkPUNorway RatMORMORT NR(Rattus norvegicus)MOR14. d TNR-ZERO: 96 ppmNR4 99 LAB FDOrig96 mg/kg/dOrigmg/kg/dGE9 wkPUNorway RatREPRSEM NR(Rattus norvegicus)REP14. d TNOAEL: 63 ppmLOAEL: 76 ppm4 99 LAB FDOrig63 mg/kg/dOrig76 mg/kg/dGE9 wkPURef #105953Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Naghii MR;Samman STitle:The Effect of Boron on Plasma Testosterone and Plasma Lipids in RatsYear:1997Source:Nutr. Res. 17(3): 523-531Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO28. d TNOAEL: 2 mg/org/dNR1 100 LAB DR 6.5 to 7Orig2 mg/org/dOrigmg/org/dADMonday, June 15, 2015Page 15 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105977Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fukuda R;Hirode M;Mori I;Chatani F;Morishima H;Mayahara HTitle:Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated DoseStudies in Rats 24) Testicular Toxicity of Boric Acid After 2- and 4-Week Administration PeriodsYear:2000Source:J. Toxicol. Sci. 25: 233-239Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO28. d TNOAEL: 497.5 mg/kg bNR2 >99.5 LAB GVOrig500 mg/kg/dOrigmg/kg/d5 wkRef #105982Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kudo S;Tanase H;Yamasaki M;Nakao M;Miyata Y;Tsuru K;Imai STitle:Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated DoseStudies in Rats 23). A Comparative 2- and 4-Week Repeated Oral Dose Testicular ToxicityStudy of Boric Acid in RatsYear:2000Source:J. Toxicol. Sci. 25: 223-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO28. d TNOAEL: 496.2 mg/kg bNR3 99.24 LAB GVOrig500 mg/kgOrigmg/kg6 wkPUNorway RatMORMORT NON(Rattus norvegicus)MOR28. d TNR-ZERO: 496.2 mg/kNR3 99.24 LAB GVOrig500 mg/kgOrigmg/kg6 wkPUNorway RatREPMOTL NON(Rattus norvegicus)REP28. d TNOAEL: 124.05 mg/kgLOAEL: 248.1 mg/kg b 3 99.24 LAB GVOrig125 mg/kgOrig250 mg/kg6 wkPURef #105983Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Strong PL;Murray FJ;Goldberg MMTitle:Developmental Effects of Boric Acid in Rats Related to Maternal Blood Boron ConcentrationsYear:1998Source:Biol. Trace Elem. Res. 66(1-3): 359-372Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROABNM NON(Rattus norvegicus)DVP20. d TNOAEL: 10 ppmLOAEL: 13 ppm5 >98 LAB FDOrig10 mg/kg/dOrig13 mg/kg/dGEPUMonday, June 15, 2015Page 16 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105983Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Strong PL;Murray FJ;Goldberg MMTitle:Developmental Effects of Boric Acid in Rats Related to Maternal Blood Boron ConcentrationsYear:1998Source:Biol. Trace Elem. Res. 66(1-3): 359-372Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO20. d TNOAEL: 10 ppmLOAEL: 13 ppm5 >98 LAB FDOrig10 mg/kg/dOrig13 mg/kg/dGEPUNorway RatGROWGHT NON(Rattus norvegicus)GRO20. d TNOAEL: 25 ppmNR5 >98 LAB FDOrig25 mg/kg/dOrigmg/kg/dGEPURef #105987Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yoshizaki H;Izumi Y;Hirayama C;Fujimoto A;Kandori H;Sugitani T;Ooshima YTitle:Availability of Sperm Examination for Male Reproductive Toxicities in Rats Treated with BoricAcidYear:1999Source:J. Toxicol. Sci. 24(3): 199-208Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO21. d TNOAEL: 149.25 mg/kgLOAEL: 497.5 mg/kg b 3 99.5 LAB GVOrig150 mg/kg/dOrig500 mg/kg/d11 wkNorway Rat REP FIDX NON(Rattus norvegicus)REP <=42. d TNOAEL: 149.25 mg/kgLOAEL: 497.5 mg/kg b 3 99.5 LAB GVOrig150 mg/kg/dOrig500 mg/kg/d11 wkNorway Rat REP MONT NON(Rattus norvegicus)REP <=42. d TNOAEL: 497.5 mg/kg bNR3 99.5 LAB GVOrig500 mg/kg/dOrigmg/kg/d11 wkNorway RatREPSPCL NON(Rattus norvegicus)REP21. d TNOAEL: 49.75 mg/kg bLOAEL: 149.25 mg/kg 3 99.5 LAB GVOrig50 mg/kg/dOrig150 mg/kg/d11 wkMonday, June 15, 2015Page 17 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106607Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Linder RE;Strader LF;Slott VL;Suarez JDTitle:Endpoints of Spermatotoxicity in the Rat After Short Duration Exposures to FourteenReproductive ToxicantsYear:1992Source:Reprod. Toxicol. 6(6): 491-505Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)GRO14. d TNOAEL: 20 mg/kg bdwtNR1 100 LAB GVOrig20 mg/kgOrigmg/kg102 to103 dNorway RatREPSPCL NON(Rattus norvegicus)REP2. d TLOAEL: 20 mg/kg bdwtNR1 100 LAB GVOrig20 mg/kgOrigmg/kg102 to103 dRef #106608Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ku WW;Chapin RE;Wine RN;Gladen BCTitle:Testicular Toxicity of Boric Acid (BA): Relationship of Dose to Lesion Development and Recoveryin the F344 RatYear:1993Source:Reprod. Toxicol. 7: 305-319Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatREPGMET NON(Rattus norvegicus)REP14. d TLOAEL: 26 ppmNR4 99.99 LAB FDOrig26 mg/kg bdwt/dOrigmg/kg bdwt/dAD70 to 80 dPURef #106613Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fail PA;George JD;Sauls HR;Dennis SW;Seely JCTitle:Effect of Boric Acid on Reproduction and Fertility of RodentsYear:1989Source:Adv. Contracept. Deliv. Syst. 5: 323-333Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Deer MouseREPFIDX NON(Peromyscus maniculatus)REP56. d TNOAEL: 4500 ppmLOAEL: 9000 ppm2 100 LAB FDOrig4500 ppmOrig9000 ppmAD10 wkHouse MouseGROWGHT NON(Mus musculus)GRO189. d TNOAEL: 4500 ppmLOAEL: 9000 ppm3 100 LAB FDOrig4500 ppmOrig9000 ppmADMonday, June 15, 2015Page 18 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106613Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fail PA;George JD;Sauls HR;Dennis SW;Seely JCTitle:Effect of Boric Acid on Reproduction and Fertility of RodentsYear:1989Source:Adv. Contracept. Deliv. Syst. 5: 323-333Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseREPMOTL NON(Mus musculus)REP189. d TLOAEL: 1000 ppmNR3 100 LAB FDOrig1000 ppmOrigppmADRef #106862Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Harrouk WA;Wheeler KE;Kimmel GL;Hogan KA;Kimmel CATitle:Effects of Hyperthermia and Boric Acid on Skeletal Development in Rat EmbryosYear:2005Source:Birth Defects Res. B Dev. Reprod. Toxicol. 74(3): 268-276Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROGAIN NON(Rattus norvegicus)GRO10. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatGROGAIN NON(Rattus norvegicus)GRO10. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatGROGAIN NON(Rattus norvegicus)GRO10. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatGROWGHT NON(Rattus norvegicus)DVP~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatGROWGHT NON(Rattus norvegicus)DVP~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatGROWGHT NON(Rattus norvegicus)DVP~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatGROWGHT NON(Rattus norvegicus)DVP~15. d TNOAEL: 1000 mg/kg bdNR3 100 LAB GVOrig1000 mg/kg bdwtOrigmg/kg bdwtGEMonday, June 15, 2015Page 19 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106862Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Harrouk WA;Wheeler KE;Kimmel GL;Hogan KA;Kimmel CATitle:Effects of Hyperthermia and Boric Acid on Skeletal Development in Rat EmbryosYear:2005Source:Birth Defects Res. B Dev. Reprod. Toxicol. 74(3): 268-276Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatMORMORT NON(Rattus norvegicus)MOR~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatMORMORT NON(Rattus norvegicus)MOR~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatMORMORT NON(Rattus norvegicus)MOR~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatMORMORT NON(Rattus norvegicus)MOR~15. d TNR-ZERO: 500 mg/kgNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatMORMORT NON(Rattus norvegicus)MOR~15. d TNR-ZERO: 500 mg/kgNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatMORMORT NON(Rattus norvegicus)MOR~15. d TNR-ZERO: 500 mg/kgNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatMORMORT NON(Rattus norvegicus)MOR~15. d TNR-ZERO: 500 mg/kgNR3 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatMORMORT NON(Rattus norvegicus)MOR~15. d TNR-ZERO: 1000 mg/kgNR3 100 LAB GVOrig1000 mg/kg bdwtOrigmg/kg bdwtGENorway RatREPNOIM NON(Rattus norvegicus)REP~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatREPNOIM NON(Rattus norvegicus)REP~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGENorway RatREPNOIM NON(Rattus norvegicus)REP~15. d TNOAEL: 500 mg/kg bdNR2 100 LAB GVOrig500 mg/kg bdwtOrigmg/kg bdwtGEMonday, June 15, 2015Page 20 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #107074Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ban Y;Naya M;Nishimura T;Kaneto M;Kishi K;Inoue T;Yoshizaki H;Ooshima YTitle:Collaborative Study on Rat Sperm Motion Analysis Using Cellsoft Series 4000 Semen AnalyzerYear:2001Source:J. Toxicol. Sci. 26(1): 9-24Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROABNM NON(Rattus norvegicus)DVP21. d TNOAEL: 50 mg/kg bdwtLOAEL: 150 mg/kg bd 3 100 LAB GVOrig50 mg/kg/dOrig150 mg/kg/dSMNorway Rat GRO WGHT NON(Rattus norvegicus)GRO 21. d TNOAEL: 150 mg/kg bdLOAEL: 500 mg/kg bd 3 100 LAB GVOrig150 mg/kg/dOrig500 mg/kg/dSMNorway Rat REP SPCL NON(Rattus norvegicus)REP 21. d TNOAEL: 50 mg/kg bdwtLOAEL: 150 mg/kg bd 3 100 LAB GVOrig50 mg/kg/dOrig150 mg/kg/dSMRef #107075Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cherrington JW;Chernoff NTitle:Periods of Vertebral Column Sensitivity to Boric Acid Treatment in CD-1 Mice In UteroYear:2002Source:Reprod. Toxicol. 16(3): 237-243Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGROABNM NON(Mus musculus)DVP10. d TLOAEL: 742.5 mg/kg bNR1 99 LAB GVOrig750 mg/kgOrigmg/kgGEPUHouse MouseGROABNM NON(Mus musculus)DVP9.5 d TLOAEL: 742.5 mg/kg bNR1 99 LAB GVOrig750 mg/kgOrigmg/kgGEPUHouse MouseGROWGHT NON(Mus musculus)DVP12. d TLOAEL: 396 mg/kg bdwNR1 99 LAB GVOrig400 mg/kgOrigmg/kgGEPUHouse MouseGROWGHT NON(Mus musculus)DVP10. d TLOAEL: 396 mg/kg bdwNR1 99 LAB GVOrig400 mg/kgOrigmg/kgGEPUHouse MouseGROWGHT NON(Mus musculus)DVP11. d TLOAEL: 396 mg/kg bdwNR1 99 LAB GVOrig400 mg/kgOrigmg/kgGEPUMonday, June 15, 2015Page 21 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #107075Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cherrington JW;Chernoff NTitle:Periods of Vertebral Column Sensitivity to Boric Acid Treatment in CD-1 Mice In UteroYear:2002Source:Reprod. Toxicol. 16(3): 237-243Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGROWGHT NON(Mus musculus)DVP12. d TLOAEL: 396 mg/kg bdwNR1 99 LAB GVOrig400 mg/kgOrigmg/kgGEPUHouse MouseGROWGHT NON(Mus musculus)GRO9.5 d TNOAEL: 742.5 mg/kg bNR1 99 LAB GVOrig750 mg/kgOrigmg/kgGEPUHouse MouseREPPROG NON(Mus musculus)REP10. d TNOAEL: 742.5 mg/kg bNR1 99 LAB GVOrig750 mg/kgOrigmg/kgGEPUHouse MouseREPPROG NON(Mus musculus)REP9.5 d TNOAEL: 742.5 mg/kg bNR1 99 LAB GVOrig750 mg/kgOrigmg/kgGEPUHouse MouseREPPROG NON(Mus musculus)REP12. d TNOAEL: 742.5 mg/kg bNR2 99 LAB GVOrig750 mg/kg/dOrigmg/kg/dGEPURef #151804Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:National Toxicology Program (NTP)Title:Final Report on the Developmental Toxicity of Boric Acid (CAS No.10043-35-3) in CD-1-SwissMiceYear:1989Source:"NTP Report # 89-250, Research Triangle Park, NC : 394 p."Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGROGAIN NON(Mus musculus)GRO17. d TNOAEL: 0.196 %LOAEL: 0.392 %1 98 to 99 LAB FDOrig0.2 %Orig0 %GE0 dgePUHouse MouseGROWGHT NON(Mus musculus)DVP17. d TLOAEL: 0.196 %NR1 98 to 99 LAB FDOrig0.2 %Orig%GE0 dgePUHouse MouseGROWGHT NON(Mus musculus)DVP17. d TNOAEL: 243.14 ppmLOAEL: 442.47 ppm 1 98 to 99 LAB FDOrig248.1 mg/kg/dOrig452 mg/kg/dGE0 dgePUMonday, June 15, 2015Page 22 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #151804Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:National Toxicology Program (NTP)Title:Final Report on the Developmental Toxicity of Boric Acid (CAS No.10043-35-3) in CD-1-SwissMiceYear:1989Source:"NTP Report # 89-250, Research Triangle Park, NC : 394 p."Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGROWGHT NON(Mus musculus)GRO12. d TNOAEL: 442.47 ppmLOAEL: 982.94 ppm 1 98 to 99 LAB FDOrig451.5 mg/kg/dOrig1003 mg/kg/dGE0 dgePUHouse Mouse MOR MORT NON(Mus musculus)MOR 17. d TLD10: 0.833 %NR1 98 to 99 LAB FDOrig0.85 %Orig%GE0 dgePUHouse MouseREPRSEM NON(Mus musculus)REP17. d TNOAEL: 0.392 %LOAEL: 0.784 %1 98 to 99 LAB FDOrig0.4 %Orig1 %GE0 dgePURef #157474Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Piersma AH;Genschow E;Verhoef A;Spanjersberg MQI;Brown NA;Brady M;Burns A;ClemannN;Seiler A;SpielmaTitle:Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAMValidation Study on Three In Vitro Embryotoxicity TestsYear:2004Source:ATLA Altern. Lab. Anim. 32(3): 275-307Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TIC50: 45 ppmNR100 LAB CMOrig45 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TIC50: 130 ppmNR100 LAB CMOrig130 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TIC50: 89.1 ppmNR100 LAB CMOrig89.1 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TIC50: 52.65 ppmNR100 LAB CMOrig52.65 ug/mlOrigug/mlEMMonday, June 15, 2015Page 23 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #157474Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Piersma AH;Genschow E;Verhoef A;Spanjersberg MQI;Brown NA;Brady M;Burns A;ClemannN;Seiler A;SpielmaTitle:Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAMValidation Study on Three In Vitro Embryotoxicity TestsYear:2004Source:ATLA Altern. Lab. Anim. 32(3): 275-307Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TNOEC: 40.5 ppmNR100 LAB CMOrig40.5 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TNOEC: 16.2 ppmNR100 LAB CMOrig16.2 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TNOEC: 10 ppmNR100 LAB CMOrig10 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TNOEC: 200 ppmNR100 LAB CMOrig200 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TNOEC: 100 ppmNR100 LAB CMOrig100 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TNOEC: 130 ppmNR100 LAB CMOrig130 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TNOEC: 50 ppmNR100 LAB CMOrig50 ug/mlOrigug/mlEMNorway RatGRODFRM CUL(Rattus norvegicus)DVP2. d TNOEC: 170 ppmNR100 LAB CMOrig170 ug/mlOrigug/mlEMMonday, June 15, 2015Page 24 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166195Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Lizzio EFTitle:A Boric Acid-Rodenticide Mixture Used in the Control of Coexisting Rodent-CockroachInfestationsYear:1986Source:Lab.Anim.Sci. 36(1): 74-76Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseMORMORT NON(Mus musculus)MOR150. d TNR-ZERO: 1.5 % w/wNR1 100 LAB FDOrig1.5 % w/wOrig% w/w8 wkPOHoneybeeTaxa_Code:BEESubacuteRef #166396Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ferreira RAC;Zacarin ECMS;Malaspina O;Bueno OC;Tomotake MEM;Pereira AMTitle:"Cellular Responses in the Malpighian Tubules of Scaptotrigona postica (Latreille, 1807)Exposed to Low Doses of Fipronil and Boric Acid"Year:2013Source:Micron 46: 57-65Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Stingless BeeMORMORT NR(Scaptotrigona postica)MOR10. d TNR-LETH: 0.75 ug/d/orNR1 100 LAB FDOrig0.75 ug/d/orgOrigug/d/orgNH4 dMonday, June 15, 2015Page 25 of 25Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Table 2 for Terrestrial AnimalStudies (species not comparable)Boric Acid CaseCAS Number:1303964PC Code:Download Date:11/4/2014Other terrestrial animalsTaxa_Code:OTAChronicRef #81004Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Green GH;Weeth HJTitle:Response of Heifers Ingesting Boron in WaterYear:1977Source:J. Anim. Sci. 46(4): 812-818Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Domesticated CattleGROGAIN NON(Bos taurus)GRO30. d TLOAEL: 4224 mg/dNR2 100 FIELDA DROrig4224 mg/dOrigmg/dRef #101951Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rust MK;Reierson DA;Klotz JHTitle:Delayed Toxicity as a Critical Factor in the Efficacy of Aqueous Baits for Controlling ArgentineAnts (Hymenoptera: Formicidae)Year:2004Source:J. Econ. Entomol. 97(3): 1017-1024Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntMORMORT NON(Linepithema humile)MOR14. d TNOAEL: 0.495 %LOAEL: 0.99 %6 99 LAB DROrig0.5 %Orig1 %PURef #105240Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Weir RJ;Jr;Fisher RSTitle:Toxicologic Studies on Borax and Boric AcidYear:1972Source:Toxicol. Appl. Pharmacol. 23: 351-364Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Monday, June 15, 2015Page 1 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105240Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Weir RJ;Jr;Fisher RSTitle:Toxicologic Studies on Borax and Boric AcidYear:1972Source:Toxicol. Appl. Pharmacol. 23: 351-364Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Domestic DogGROWGHT NON(Canis familiaris)GRO90. d TNOAEL: 1750 ppmNR3 100 LAB FDOrig1750 ppmOrigppmDomestic DogGROWGHT NON(Canis familiaris)GRO90. d TNOAEL: 1750 ppmNR3 100 LAB FDOrig1750 ppmOrigppmDomestic DogGROWGHT NON(Canis familiaris)GRO90. d TNOAEL: 1750 ppmNR3 100 LAB FDOrig1750 ppmOrigppmDomestic DogGROWGHT NON(Canis familiaris)GRO90. d TNOAEL: 1750 ppmNR3 100 LAB FDOrig1750 ppmOrigppmRef #106171Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:US Borax and Chemical CorpTitle:Initial Submission: Developmental Toxicity of Boric Acid in New Zealand White Rabbits (FinalReport) with Attachments and Cover Letter Dated 010692Year:1992Source:EPA/OTS Doc.#88-920000648 : 186 p.Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.European RabbitGROABNM NON(Oryctolagus cuniculus)DVP25. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d~5.5 moEuropean Rabbit GRO GAIN NON(Oryctolagus cuniculus)GRO 14. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d~5.5 moEuropean Rabbit REP RSEM NON(Oryctolagus cuniculus)REP 25. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d~5.5 moMonday, June 15, 2015Page 2 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106690Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Oi DH;Vail KM;Williams DFTitle:Laboratory Evaluation of a Boric Acid Liquid Bait on Colonies of Tapinoma melanocephalumArgentine Ants and Pharaoh Ants (Hymenoptera: Formicidae)Year:1996Source:J. Econ. Entomol. 89(3): 673-677Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntMORMORT NON(Linepithema humile)MOR70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYArgentine AntMORMORT NON(Linepithema humile)MOR70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYGhost AntMORMORT NON(Tapinoma melanocephalum)MOR70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYGhost AntMORMORT NON(Tapinoma melanocephalum)MOR70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYPharoah AntMORMORT NON(Monomorium pharaonis)MOR70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYPharoah AntMORMORT NON(Monomorium pharaonis)MOR70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYRef #106889Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Vankova J;Vobrazkova E;Samsinak KTitle:The Control of Monomorium pharaonis (Hymenoptera: Formicidae) with Bacillus thuringiensisYear:1975Source:J. Invertebr. Pathol. 26(2): 159-163Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Pharoah AntMORMORT NON(Monomorium pharaonis)MOR154. d TNR-ZERO: 1.3 %NR1 100 LAB FDOrig1.3 %Orig%Monday, June 15, 2015Page 3 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #107048Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Marr MC;Myers CB;Seely JC;Heindel JJ;Schwetz BATitle:The Developmental Toxicity of Boric Acid in RabbitsYear:1996Source:Fundam. Appl. Toxicol. 34(2): 176-187Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.European RabbitGROABNM NON(Oryctolagus cuniculus)DVP14. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d5.5 moEuropean Rabbit GRO GAIN NON(Oryctolagus cuniculus)GRO 14. d TNOAEL: 61.88 mg/kg bLOAEL: 123.75 mg/kg 3 99 LAB GVOrig62.5 mg/kg/dOrig125 mg/kg/d5.5 moEuropean Rabbit MOR MORT NON(Oryctolagus cuniculus)MOR 14. d TNR-ZERO: 272.25 mg/NR1 99 LAB GVOrig275 mg/kg/dOrigmg/kg/dEuropean RabbitREPRSEM NON(Oryctolagus cuniculus)REP14. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d5.5 moRef #166197Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hyrsl P;Buyukguzel E;Buyukguzel KTitle:The Effects of Boric Acid-Induced Oxidative Stress on Antioxidant Enzymes and Survivorship inGalleria mellonellaYear:2007Source:Arch. Insect Biochem. Physiol. 66(1): 23-31Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Greater Wax MothGRODVLP NR(Galleria mellonella)DVP<37. d TLOAEL: 1237.5 ppmNR1 99 LAB FDOrig1250 ppmOrigppmLV1 insPUGreater Wax MothGRODVLP NR(Galleria mellonella)DVP<43. d TLOAEL: 1237.5 ppmNR1 99 LAB FDOrig1250 ppmOrigppmLV1 insPUGreater Wax MothGRODVLP NR(Galleria mellonella)DVP<28. d TLOAEL: 613.8 ppmNR1 99 LAB FDOrig620 ppmOrigppmLV1 insPUGreater Wax MothGRODVLP NR(Galleria mellonella)DVP<28. d TNOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV1 insPUMonday, June 15, 2015Page 4 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166197Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hyrsl P;Buyukguzel E;Buyukguzel KTitle:The Effects of Boric Acid-Induced Oxidative Stress on Antioxidant Enzymes and Survivorship inGalleria mellonellaYear:2007Source:Arch. Insect Biochem. Physiol. 66(1): 23-31Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Greater Wax MothGRODVLP NR(Galleria mellonella)DVP<37. d TNOAEL: 613.8 ppmNR1 99 LAB FDOrig620 ppmOrigppmLV1 insPUGreater Wax MothGRODVLP NR(Galleria mellonella)DVP<43. d TNOAEL: 1237.5 ppmNR1 99 LAB FDOrig1250 ppmOrigppmLV1 insPURef #166366Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Huguier P;Manier N;Meline C;Bauda P;Pandard PTitle:Improvement of the Caenorhabditis elegans Growth and Reproduction Test to Assess theEcotoxicity of Soils and Complex MatricesYear:2013Source:Environ. Toxicol. Chem. 32(9): 2100-2108Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.NematodeGROGGRO NR(Caenorhabditis elegans)GRO4. d TEC50: 1559 ppmNR1 100 LAB PR 5.5Orig1559 mg/kgOrigmg/kgNematodeGROGGRO NR(Caenorhabditis elegans)GRO4. d TNOEC: 536 ppmLOEC: 831 ppm1 100 LAB PR 5.5Orig536 mg/kgOrig831 mg/kgNematodeREPGREP NR(Caenorhabditis elegans)REP4. d TEC50: 1259 ppmNR1 100 LAB PR 5.5Orig1259 mg/kgOrigmg/kgNematodeREPGREP NR(Caenorhabditis elegans)REP4. d TNOEC: 831 ppmLOEC: 1288 ppm1 100 LAB PR 5.5Orig831 mg/kgOrig1288 mg/kgMonday, June 15, 2015Page 5 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166372Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Princz JI;Behan-Pelletier VM;Scroggins RP;Siciliano SDTitle:Oribatid Mites in Soil Toxicity Testing - The Use of Oppia nitens (C.L. Koch) as a New TestSpeciesYear:2010Source:Environ. Toxicol. Chem. 29(4): 971-979Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.MiteREPPROG NAT(Oppia nitens)REP28. d TIC50: 78 ppmNR1 100 LAB DA 5.2Orig78 mg/kg dry wtOrigmg/kg dry wtADMiteREPPROG NAT(Oppia nitens)REP28. dTIC50: 96 ppmNR1 100 LAB DA 4.4Orig96 mg/kg dry wtOrigmg/kg dry wtADMiteREPPROG NAT(Oppia nitens)REP28. dTIC50: 118 ppmNR1 100 LAB DA 4.4Orig118 mg/kg dry wtOrigmg/kg dry wtADRef #166381Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Capinera JLTitle:"Cuban Brown Snail, Zachrysia provisoria (Gastropoda): Damage Potential and Control"Year:2013Source:Crop Prot. 52(0): 57-63Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Cuba Garden ZachrysiaGROWGHT NR(Zachrysia provisoria)GRO14. d TLOAEL: 0.0125 gNR1 5 LAB ENOrig0.25 gOriggGRef #166393Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Becker L;Scheffczyk A;Forster B;Oehlmann J;Princz J;Rombke J;Moser TTitle:"Effects of Boric Acid on Various Microbes, Plants, and Soil Invertebrates"Year:2011Source:J. Soils Sediments 11(2): 238-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.EarthwormREPPROG ART(Enchytraeus crypticus)REP28. d TEC50: 218.9 mg/kg d sNR1 >=99.5 LAB DA 5.6 to 6.1Orig220 mg/kg d soilOrigmg/kg d soilADPUMonday, June 15, 2015Page 6 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166393Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Becker L;Scheffczyk A;Forster B;Oehlmann J;Princz J;Rombke J;Moser TTitle:"Effects of Boric Acid on Various Microbes, Plants, and Soil Invertebrates"Year:2011Source:J. Soils Sediments 11(2): 238-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.EarthwormREPPROG ART(Eisenia fetida)REP56. d TEC50: 481.58 mg/kg dNR1 >=99.5 LAB DA 5.8 to 6.1Orig484 mg/kg d soilOrigmg/kg d soilAD>2 to <12moPUEarthwormREPPROG ART(Enchytraeus luxuriosus)REP28. d TEC50: 226.86 mg/kg dNR1 >=99.5 LAB DA 5.8 to 6.7Orig228 mg/kg d soilOrigmg/kg d soilADPUNematodeREPPROG NAT(Caenorhabditis elegans)REP4. d TEC50: 743.26 mg/kg dNR1 >=99.5 LAB DA 5.7 to 5.8Orig747 mg/kg d soilOrigmg/kg d soilPURef #166586Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Durmus Y;Buyukguzel KTitle:Biological and Immune Response of Galleria mellonella (Lepidoptera: Pyralidae) to SodiumTetraborateYear:2008Source:J. Econ. Entomol. 101(3): 777-783Test Chemical:Boron sodium oxide (B4Na2O7)CAS Number:1330434Lifestage:AgeFormul.Greater Wax MothGRODVLP NON(Galleria mellonella)DVP7. ins TNOAEL: 0.198 %LOAEL: 0.297 %1 99 LAB FDOrig0.2 %Orig0 %LV1 insCRYSubacuteRef #64756Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Vail KM;Williams DFTitle:Toxicity of a Boric Acid-Sucrose Water Bait to Solenopsis invicta (Hymenoptera: Formicidae)Year:1997Source:J. Econ. Entomol. 90(2): 488-491Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 7 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #64756Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Vail KM;Williams DFTitle:Toxicity of a Boric Acid-Sucrose Water Bait to Solenopsis invicta (Hymenoptera: Formicidae)Year:1997Source:J. Econ. Entomol. 90(2): 488-491Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Red Imported Fire AntMORMORT NON(Solenopsis invicta)MOR3. d TLC50: 1.26 % w/vNR9 99 LAB FDOrig1.27 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR8. d TLC50: 0.109 % w/vNR9 99 LAB FDOrig0.11 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR5. d TLC50: 0.436 % w/vNR9 99 LAB FDOrig0.44 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR6. d TLC50: 0.218 % w/vNR9 99 LAB FDOrig0.22 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR7. d TLC50: 0.139 % w/vNR9 99 LAB FDOrig0.14 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR4. d TLC50: 0.762 % w/vNR9 99 LAB FDOrig0.77 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR4. d TLC90: 1.23 % w/vNR9 99 LAB FDOrig1.24 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR7. d TLC90: 0.317 % w/vNR9 99 LAB FDOrig0.32 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR6. d TLC90: 0.564 % w/vNR9 99 LAB FDOrig0.57 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR5. d TLC90: 0.97 % w/vNR9 99 LAB FDOrig0.98 % w/vOrig% w/vCRYRed Imported Fire AntMORMORT NON(Solenopsis invicta)MOR3. d TLC90: 2.21 % w/vNR9 99 LAB FDOrig2.23 % w/vOrig% w/vCRYMonday, June 15, 2015Page 8 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #64756Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Vail KM;Williams DFTitle:Toxicity of a Boric Acid-Sucrose Water Bait to Solenopsis invicta (Hymenoptera: Formicidae)Year:1997Source:J. Econ. Entomol. 90(2): 488-491Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Red Imported Fire AntMORMORT NON(Solenopsis invicta)MOR8. d TLC90: 0.257 % w/vNR9 99 LAB FDOrig0.26 % w/vOrig% w/vCRYRef #101951Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rust MK;Reierson DA;Klotz JHTitle:Delayed Toxicity as a Critical Factor in the Efficacy of Aqueous Baits for Controlling ArgentineAnts (Hymenoptera: Formicidae)Year:2004Source:J. Econ. Entomol. 97(3): 1017-1024Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntMORMORT NON(Linepithema humile)MOR4. d TLT50: 0.544 %NR6 99 LAB DROrig0.55 %Orig%PURef #106689Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz J;Greenberg L;Venn ECTitle:Liquid Boric Acid Bait for Control of the Argentine Ant (Hymenoptera: Formicidae)Year:1998Source:J. Econ. Entomol. 91(4): 910-914Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntMORMORT CUL(Linepithema humile)MOR1.7 d TLT50: 0.99 %NR5 99 LAB DROrig1 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR1.8 d TLT50: 0.792 %NR5 99 LAB DROrig0.8 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR5. d TLT50: 0.198 %NR5 99 LAB DROrig0.2 %Orig%CRYMonday, June 15, 2015Page 9 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106689Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz J;Greenberg L;Venn ECTitle:Liquid Boric Acid Bait for Control of the Argentine Ant (Hymenoptera: Formicidae)Year:1998Source:J. Econ. Entomol. 91(4): 910-914Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntMORMORT CUL(Linepithema humile)MOR2.6 d TLT50: 0.594 %NR5 99 LAB DROrig0.6 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR3.4 d TLT50: 0.396 %NR5 99 LAB DROrig0.4 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR2.6 d TLT50: 0.594 %NR5 99 LAB DROrig0.6 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR3.6 d TLT50: 0.396 %NR5 99 LAB DROrig0.4 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR1.6 d TLT50: 0.792 %NR5 99 LAB DROrig0.8 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR1.4 d TLT50: 0.99 %NR5 99 LAB DROrig1 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR5.6 d TLT50: 0.198 %NR5 99 LAB DROrig0.2 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR1.9 d TLT90: 0.99 %NR5 99 LAB DROrig1 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR2.3 d TLT90: 0.792 %NR5 99 LAB DROrig0.8 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR3.4 d TLT90: 0.594 %NR5 99 LAB DROrig0.6 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR4.6 d TLT90: 0.396 %NR5 99 LAB DROrig0.4 %Orig%CRYMonday, June 15, 2015Page 10 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106689Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz J;Greenberg L;Venn ECTitle:Liquid Boric Acid Bait for Control of the Argentine Ant (Hymenoptera: Formicidae)Year:1998Source:J. Econ. Entomol. 91(4): 910-914Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntMORMORT CUL(Linepithema humile)MOR7.8 d TLT90: 0.198 %NR5 99 LAB DROrig0.2 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR2.8 d TLT90: 0.99 %NR5 99 LAB DROrig1 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR3.7 d TLT90: 0.594 %NR5 99 LAB DROrig0.6 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR5.4 d TLT90: 0.396 %NR5 99 LAB DROrig0.4 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR8.1 d TLT90: 0.198 %NR5 99 LAB DROrig0.2 %Orig%CRYArgentine AntMORMORT CUL(Linepithema humile)MOR3.4 d TLT90: 0.792 %NR5 99 LAB DROrig0.8 %Orig%CRYMonday, June 15, 2015Page 11 of 11Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Table 3 for Terrestrial Animal Studies (endpoints not comparable)Boric Acid CaseCAS Number:10043353PC Code:Download Date:11/4/2014BirdsTaxa_Code:BIRDOtherRef #39727Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hoffman DJ;Camardese MB;LeCaptain LJ;Pendleton GWTitle:Effects of Boron on Growth and Physiology in Mallard DucklingsYear:1990Source:Environ. Toxicol. Chem. 9(3): 335-346Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckACCRSDE NON(Anas platyrhynchos)ACC70. d TLOAEL: 120 ppmNR3 99 FIELDA FDOrig120 ppmOrigppm1 dPOMallard DuckBCMSBDH NON(Anas platyrhynchos)ENZ70. d TNOAEL: 120 ppmLOAEL: 430 ppm3 99 FIELDA FDOrig120 ppmOrig430 ppm1 dPOMallard DuckBCMTRIG NON(Anas platyrhynchos)BCM70. d TLOAEL: 120 ppmNR3 99 FIELDA FDOrig120 ppmOrigppm1 dPOMallard DuckBEHFCNS NON(Anas platyrhynchos)FDB14. d TLOAEL: 120 ppmNR3 99 FIELDA FDOrig120 ppmOrigppm1 dPOMallard DuckCELDNAC NON(Anas platyrhynchos)GEN70. d TNOAEL: 1750 ppmNR3 99 FIELDA FDOrig1750 ppmOrigppm1 dPOMallard DuckCELLESI NON(Anas platyrhynchos)HIS70. d TNOAEL: 1750 ppmNR3 99 FIELDA FDOrig1750 ppmOrigppm1 dPOMallard DuckGROSMIX NON(Anas platyrhynchos)MPH70. d TNOAEL: 430 ppmLOAEL: 1750 ppm3 99 FIELDA FDOrig430 ppmOrig1750 ppm1 dPOMallard DuckGROSMIX NON(Anas platyrhynchos)MPH70. d TNOAEL: 430 ppmLOAEL: 1750 ppm3 99 FIELDA FDOrig430 ppmOrig1750 ppm1 dPOMonday, June 15, 2015Page 1 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #39727Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hoffman DJ;Camardese MB;LeCaptain LJ;Pendleton GWTitle:Effects of Boron on Growth and Physiology in Mallard DucklingsYear:1990Source:Environ. Toxicol. Chem. 9(3): 335-346Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckMORSURV NON(Anas platyrhynchos)MOR70. d TNOAEL: 1750 ppmNR3 99 FIELDA FDOrig1750 ppmOrigppm1 dPORef #39733Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hoffman DJ;Sanderson CJ;LeCaptain LJ;Cromartie E;Pendleton GWTitle:"Interactive Effects of Boron, Selenium, and Dietary Protein on Survival, Growth, and Physiologyin Mallard Ducklings"Year:1991Source:Arch. Environ. Contam. Toxicol. 20(2): 288-294Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckACCRSDE NON(Anas platyrhynchos)ACC28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMAATT NON(Anas platyrhynchos)ENZ28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMALPH NON(Anas platyrhynchos)ENZ28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMASAT NON(Anas platyrhynchos)ENZ28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMCACO NON(Anas platyrhynchos)BCM28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMCHOL NON(Anas platyrhynchos)BCM28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMCRKI NON(Anas platyrhynchos)ENZ28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMonday, June 15, 2015Page 2 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #39733Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hoffman DJ;Sanderson CJ;LeCaptain LJ;Cromartie E;Pendleton GWTitle:"Interactive Effects of Boron, Selenium, and Dietary Protein on Survival, Growth, and Physiologyin Mallard Ducklings"Year:1991Source:Arch. Environ. Contam. Toxicol. 20(2): 288-294Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckBCMGLPX NON(Anas platyrhynchos)ENZ28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMGLRE NON(Anas platyrhynchos)ENZ28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMGLUC NON(Anas platyrhynchos)BCM28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMHMCT NON(Anas platyrhynchos)BCM28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMHMGL NON(Anas platyrhynchos)BCM28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMLADH NON(Anas platyrhynchos)ENZ28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMPCON NON(Anas platyrhynchos)BCM28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMPRTL NON(Anas platyrhynchos)BCM28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMSBDH NON(Anas platyrhynchos)ENZ28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMSECO NON(Anas platyrhynchos)BCM28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckBCMTRIG NON(Anas platyrhynchos)BCM28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMonday, June 15, 2015Page 3 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #39733Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hoffman DJ;Sanderson CJ;LeCaptain LJ;Cromartie E;Pendleton GWTitle:"Interactive Effects of Boron, Selenium, and Dietary Protein on Survival, Growth, and Physiologyin Mallard Ducklings"Year:1991Source:Arch. Environ. Contam. Toxicol. 20(2): 288-294Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Mallard DuckBCMURIC NON(Anas platyrhynchos)BCM28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckCELLESI NON(Anas platyrhynchos)HIS28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckGROLGTH NON(Anas platyrhynchos)MPH28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckGROWGHT NON(Anas platyrhynchos)MPH28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckGROWGHT NON(Anas platyrhynchos)MPH28. d TLOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPOMallard DuckMORSURV NON(Anas platyrhynchos)MOR28. d TNOAEL: 1000 ppmNR1 99 FIELDA FDOrig1000 ppmOrigppm1 dPORef #55659Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Wilson JH;Ruszler PLTitle:Effects of Dietary Boron on Poultry Bone StrengthYear:1995Source:Trans ASAE (Am. Soc. Agric. Eng.) 38(1): 167-170Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenACCRSDE NON(Gallus domesticus)ACC28. d TLOAEL: 56 ppmNR1 100 LAB FDOrig56 mg/kgOrigmg/kgDomestic ChickenPHYBNDS NON(Gallus domesticus)PHY28. d TNOAEL: 56 ppmNR1 100 LAB FDOrig56 mg/kgOrigmg/kgMonday, June 15, 2015Page 4 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #79568Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rennie JS;Whitehead CC;Montanari ATitle:Effects of Dietary Borate and Aluminate on Riboflavin Metabolism in the Breeding HenYear:1990Source:Res. Vet. Sci. 49(2): 253-255Test Chemical:"Boric acid (HBO2), sodium salt"CAS Number:7775191Lifestage:AgeFormul.Domestic ChickenBCMRIBO NON(Gallus domesticus)BCM7. d TLOAEL: 15000 ppmNR1 100 LAB FDOrig15 g/kgOrigg/kgRef #81100Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Bai Y;Hunt CDTitle:Dietary Boron Enhances Efficacy of Cholecalciferol in Broiler ChicksYear:1996Source:J. Trace Elem. Exp. Med. 9(3): 117-132Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenBCMCACO NON(Gallus domesticus)BCM27. d TNOAEL: 3 ppmNR1 100 LAB FDOrig3 mg/kgOrigmg/kgJV1 dDomestic ChickenBCMCACO NON(Gallus domesticus)BCM26. d TNOAEL: 3 ppmNR1 100 LAB FDOrig3 mg/kgOrigmg/kgJV1 dDomestic ChickenGROWGHT NON(Gallus domesticus)MPH27. d TNOAEL: 3 ppmNR1 100 LAB FDOrig3 mg/kgOrigmg/kgJV1 dDomestic ChickenPHYFDCV NON(Gallus domesticus)PHYd TNOAEL: 3 ppmNR1 100 LAB FDOrig3 mg/kgOrigmg/kgJV1 dDomestic ChickenPHYFDCV NON(Gallus domesticus)PHYd TNOAEL: 3 ppmNR1 100 LAB FDOrig3 mg/kgOrigmg/kgJV1 dMonday, June 15, 2015Page 5 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105865Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Sander JE;Dufour L;Wyatt RD;Bush PB;Page RKTitle:Acute Toxicity of Boric Acid and Boron Tissue Residues After Chronic Exposure in BroilerChickensYear:1991Source:Avian Dis. 35(4): 745-749Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenACCRSDE NON(Gallus domesticus)ACC21. d TNOAEL: 1250 ppmLOAEL: 2500 ppm4 100 LAB FDOrig1250 ppmOrig2500 ppm1 dPUDomestic ChickenACCRSDE LIT(Gallus domesticus)ACC15. d TNOAEL: 7.2 kg/9.9 m2NR3 100 LAB ENOrig7.2 kg/9.9 m2Origkg/9.9 m21 dPURef #105868Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dufour L;Sander JE;Wyatt RD;Rowland GN;Page RKTitle:Experimental Exposure of Broiler Chickens to Boric Acid to Assess Clinical Signs and Lesions ofToxicosisYear:1992Source:Avian Dis. 36(4): 1007-1011Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenBEHFCNS NON(Gallus domesticus)FDB14. d TNOAEL: 1250 ppmLOAEL: 2500 ppm4 100 LAB FDOrig1250 ppmOrig2500 ppm1 dPUDomestic ChickenBEHFCNS LIT(Gallus domesticus)FDB15. d TNOAEL: 3.6 kg/9.3 m2LOAEL: 7.2 kg/9.3 m2 3 100 LAB ENOrig3.6 kg/9.3 m2Orig7 kg/9.3 m21 dPUDomestic Chicken MOR MORT LIT(Gallus domesticus)MOR 15. d TNOAEL: 3.6 kg/9.3 m2LOAEL: 7.2 kg/9.3 m2 3 100 LAB ENOrig3.6 kg/9.3 m2Orig7 kg/9.3 m21 dPUDomestic Chicken MOR MORT LIT(Gallus domesticus)MOR 15. d TNR-ZERO: 3.6 kg/9.3NR3 100 LAB ENOrig3.6 kg/9.3 m2Origkg/9.3 m21 dPUDomestic ChickenPHYFDCV LIT(Gallus domesticus)PHY15. d TNOAEL: 3.6 kg/9.3 m2LOAEL: 7.2 kg/9.3 m2 3 100 LAB ENOrig3.6 kg/9.3 m2Orig7 kg/9.3 m21 dPUDomestic Chicken PHY FDCV NON(Gallus domesticus)PHY 14. d TNOAEL: 2500 ppmLOAEL: 5000 ppm4 100 LAB FDOrig2500 ppmOrig5000 ppm1 dPUMonday, June 15, 2015Page 6 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #111573Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yeslibag D;Eren MTitle:"Effects of Dietary Boric Acid Supplementation on Performance, Eggshell Quality and SomeSerum Parameters in Aged Laying Hens"Year:2008Source:Turk. J. Vet. Anim. Sci. 32(2): 113-117Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenBCMMGCO NR(Gallus domesticus)BCM75. d TNOAEL: 50 ppmLOAEL: 99.995 ppm 1 99.995 LAB FDOrig50 mg/kgOrig100 mg/kg60 dPUDomestic Chicken BEH FCNS NR(Gallus domesticus)FDB 75. d TLOAEL: 25 ppmNR1 99.995 LAB FDOrig25 mg/kgOrigmg/kg60 dPUDomestic ChickenPHYFDCV NR(Gallus domesticus)PHY75. d TNOAEL: 100 ppmNR1 99.995 LAB FDOrig100 mg/kgOrigmg/kg60 dPUDomestic ChickenREPSTGH NR(Gallus domesticus)AEGd TLOAEL: 25 ppmNR1 99.995 LAB FDOrig25 mg/kgOrigmg/kg60 dPURef #111574Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Olgun O;Cufadar Y;Yildiz AOTitle:Effects of Boron Supplementation Fed with Low Calcium to Diet on Performance and Egg Qualityin Molted Laying HensYear:2008Source:J. Anim. Vet. Adv. 8(4): 650-654Test Chemical:Boron sodium oxide (B4Na2O7)CAS Number:1330434Lifestage:AgeFormul.Domestic ChickenBCMSGRV NON(Gallus domesticus)BCM84. d TNOAEL: 300 ppmNR1 100 LAB FDOrig300 mg/kg dietOrigmg/kg diet78 wkPODomestic ChickenBEHFCNS NON(Gallus domesticus)FDB84. d TNOAEL: 300 ppmNR1 100 LAB FDOrig300 mg/kg dietOrigmg/kg diet78 wkPODomestic ChickenPHYFDCV NON(Gallus domesticus)PHY84. d TNOAEL: 300 ppmNR1 100 LAB FDOrig300 mg/kg dietOrigmg/kg diet78 wkPODomestic ChickenREPSIZE NON(Gallus domesticus)AEG84. d TNOAEL: 300 ppmNR1 100 LAB FDOrig300 mg/kg dietOrigmg/kg diet78 wkPOMonday, June 15, 2015Page 7 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166581Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eren M;Uyanik F;Kucukersan STitle:"The Influence of Dietary Boron Supplementation on Egg Quality and Serum Calcium, InorganicPhosphorus, Magnesium Levels and Alkaline Phosphatase Activity in Laying Hens"Year:2004Source:Res. Vet. Sci. 76(3): 203-210Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic ChickenBCMALPH NON(Gallus domesticus)ENZ56. d TNOAEL: 400 ppmNR1 100 LAB FDOrig400 mg/kg dietOrigmg/kg diet136 dDomestic ChickenBCMMGCO NON(Gallus domesticus)BCM28. d TNOAEL: 5 ppmLOAEL: 10 ppm1 100 LAB FDOrig5 mg/kg dietOrig10 mg/kg diet136 dDomestic ChickenBEHFCNS NON(Gallus domesticus)FDB<=56. d TNOAEL: 200 ppmLOAEL: 400 ppm1 100 LAB FDOrig200 mg/kg dietOrig400 mg/kg diet136 dDomestic ChickenPHYFDCV NON(Gallus domesticus)PHY<=56. d TNOAEL: 400 ppmNR1 100 LAB FDOrig400 mg/kg dietOrigmg/kg diet136 dDomestic ChickenREPWGHT NON(Gallus domesticus)AEG<=56. d TNOAEL: 100 ppmLOAEL: 200 ppm1 100 LAB FDOrig100 mg/kg dietOrig200 mg/kg diet136 dRodentTaxa_Code:RODOtherRef #36437Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dixon RL;Sherins RJ;Lee IPTitle:Assessment of Environmental Factors Affecting Male FertilityYear:1979Source:Environ. Health Perspect. 30: 53-68Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatBCMFOSH NON(Rattus norvegicus)HRM30. d TLOAEL: 500 ppmNR3 100 LAB FDOrig500 ppmOrigppmMonday, June 15, 2015Page 8 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #36437Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dixon RL;Sherins RJ;Lee IPTitle:Assessment of Environmental Factors Affecting Male FertilityYear:1979Source:Environ. Health Perspect. 30: 53-68Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatBCMGAPD NON(Rattus norvegicus)ENZ30. d TLOAEL: 500 ppmNR3 100 LAB FDOrig500 ppmOrigppmNorway RatBEHFCNS NON(Rattus norvegicus)FDB60. d TNOAEL: 2000 ppmNR3 100 LAB FDOrig2000 ppmOrigppmNorway RatGROSTBD NON(Rattus norvegicus)MPH60. d TLOAEL: 500 ppmNR3 100 LAB FDOrig500 ppmOrigppmRef #48743Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dixon RL;Lee IP;Sherins RJTitle:Methods to Assess Reproductive Effects of Environmental Chemicals: Studies of Cadmium andBoron Administered OrallyYear:1976Source:Environ. Health Perspect. 13: 59-67Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatBCMACPH NON(Rattus norvegicus)ENZ90. d TNOAEL: 6 ppmNR3 100 LAB DROrig6 mg/LOrigmg/LADNorway RatBCMFRCT NON(Rattus norvegicus)BCM90. d TNOAEL: 6 ppmNR3 100 LAB DROrig6 mg/LOrigmg/LADNorway RatGROWGHT NON(Rattus norvegicus)MPH30. d TLOAEL: 0.3 ppmNR3 100 LAB DROrig0.3 mg/LOrigmg/LADNorway RatPHYLABS NON(Rattus norvegicus)PHY<70. d TNOAEL: 450 ppmNR3 100 LAB DTOrig450 mg/kgOrigmg/kgADMonday, June 15, 2015Page 9 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #72114Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:National Toxicology Program (NTP)Title:Toxicology and Carcinogenesis Studies of Boric Acid (CAS No.10043-35-3) in B6C3F1 Mice(Feed Studies)Year:1987Source:"NTP Rep.No.TR324, NIH Publ.No.88-2580, U.S.Dep.of Health and Hum.Serv.,Washington, DC : 126 p."Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseMORSURV NON(Mus musculus)MOR588. d TLOAEL: 2521 ppmNR2 99.7 LAB FDOrig2521 ppmOrigppm7 wkPUHouse MouseMORSURV NON(Mus musculus)MOR742. d TNOAEL: 5034 ppmNR2 99.7 LAB FDOrig5034 ppmOrigppm7 wkPURef #92705Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Strong PL;Marr MC;Myers CB;Murray FJTitle:Developmental Toxicity NOAEL and Postnatal Recovery in Rats fed Boric Acid During GestationYear:1996Source:Fundam. Appl. Toxicol. 32(2): 179-193Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBEHFCNS NON(Rattus norvegicus)FDB20. d TNOAEL: 141.47 ppmNR1 99 LAB FDOrig142.9 mg/kg/dOrigmg/kg/dGE8 wkPUNorway RatGROWGHT NON(Rattus norvegicus)MPH20. d TNOAEL: 75.14 ppmLOAEL: 141.471 ppm 1 99 LAB FDOrig75.9 mg/kg/dOrig143 mg/kg/dGE8 wkPURef #105240Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Weir RJ;Jr;Fisher RSTitle:Toxicologic Studies on Borax and Boric AcidYear:1972Source:Toxicol. Appl. Pharmacol. 23: 351-364Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)MPH90. d TLOAEL: 1750 ppmNR5 100 LAB FDOrig1750 ppmOrigppmYOMonday, June 15, 2015Page 10 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105240Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Weir RJ;Jr;Fisher RSTitle:Toxicologic Studies on Borax and Boric AcidYear:1972Source:Toxicol. Appl. Pharmacol. 23: 351-364Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)MPH90. d TLOAEL: 1750 ppmNR5 100 LAB FDOrig1750 ppmOrigppmYONorway RatGROWGHT NON(Rattus norvegicus)MPH90. d TLOAEL: 1750 ppmNR5 100 LAB FDOrig1750 ppmOrigppmYONorway RatGROWGHT NON(Rattus norvegicus)MPH90. d TLOAEL: 1750 ppmNR5 100 LAB FDOrig1750 ppmOrigppmYONorway RatGROWGHT NON(Rattus norvegicus)MPH182.64 d TNOAEL: 350 ppmLOAEL: 1170 ppm3 100 LAB FDOrig350 ppmOrig1170 ppmNorway RatGROWGHT NON(Rattus norvegicus)MPH182.64 d TNOAEL: 350 ppmLOAEL: 1170 ppm3 100 LAB FDOrig350 ppmOrig1170 ppmNorway RatPHYFDCV NON(Rattus norvegicus)PHY90. d TNOAEL: 525 ppmLOAEL: 1750 ppm5 100 LAB FDOrig525 ppmOrig1750 ppmYONorway RatPHYFDCV NON(Rattus norvegicus)PHY90. d TNOAEL: 1750 ppmLOAEL: 5250 ppm5 100 LAB FDOrig1750 ppmOrig5250 ppmYORef #105510Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Lee IP;Sherins RJ;Dixon RLTitle:Evidence for Induction of Germinal Aplasia in Male Rats by Environmental Exposure to BoronYear:1978Source:Toxicol. Appl. Pharmacol. 45: 577-590Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatBCMFOSH NON(Rattus norvegicus)HRM30. d TLOAEL: 500 ppmNR3 100 LAB FDOrig500 ppmOrigppmADMonday, June 15, 2015Page 11 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105510Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Lee IP;Sherins RJ;Dixon RLTitle:Evidence for Induction of Germinal Aplasia in Male Rats by Environmental Exposure to BoronYear:1978Source:Toxicol. Appl. Pharmacol. 45: 577-590Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Norway RatBCMSBDH NON(Rattus norvegicus)ENZ60. d TLOAEL: 500 ppmNR3 100 LAB FDOrig500 ppmOrigppmADNorway RatGROSTBD NON(Rattus norvegicus)MPH60. d TLOAEL: 500 ppmNR3 100 LAB FDOrig500 ppmOrigppmADRef #105864Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Linder RE;Strader LF;Rehnberg GLTitle:Effect of Acute Exposure to Boric Acid on the Male Reproductive System of the RatYear:1990Source:J. Toxicol. Environ. Health 31: 133-146Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBCMLUTH NON(Rattus norvegicus)HRM14. d TNOAEL: 1980 mg/kg bdNR4 99 LAB GVOrig2000 mg/kgOrigmg/kgAD105 dPUNorway RatGROABNM NON(Rattus norvegicus)MPH14. d TLOAEL: 1980 mg/kg bdNR1 99 LAB GVOrig2000 mg/kgOrigmg/kgAD105 dPUNorway RatGROABNM NON(Rattus norvegicus)MPH14. d TNOAEL: 495 mg/kg bdLOAEL: 990 mg/kg bd 4 99 LAB GVOrig500 mg/kgOrig1000 mg/kgAD105 dPUNorway Rat GRO WGHT NON(Rattus norvegicus)MPH 14. d TLOAEL: 1980 mg/kg bdNR1 99 LAB GVOrig2000 mg/kgOrigmg/kgAD105 dPUMonday, June 15, 2015Page 12 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105867Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hunt CD;Herbel JLTitle:"Effects of Dietary Boron on Calcium and Mineral Metabolism in the Streptozotocin-Injected,Vitamin D3-Deprived Rat"Year:1991Source:Magnes. Trace Elem. 10(5-6): 387-408Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatACCRSDE NON(Rattus norvegicus)ACC55. d TLOAEL: 2.4 ppmNR1 100 LAB FDOrig2.4 mg/kg dietOrigmg/kg dietNorway RatBCMALPH NON(Rattus norvegicus)ENZ55. d TNOAEL: 2.4 ppmNR1 100 LAB FDOrig2.4 mg/kg dietOrigmg/kg dietNorway RatBCMKCON NON(Rattus norvegicus)BCM55. d TLOAEL: 2.4 ppmNR1 100 LAB FDOrig2.4 mg/kg dietOrigmg/kg dietNorway RatPHYVOLU NON(Rattus norvegicus)PHY55. d TNOAEL: 2.4 ppmNR1 100 LAB FDOrig2.4 mg/kg dietOrigmg/kg dietRef #105885Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Dieter MPTitle:Toxicity and Carcinogenicity Studies of Boric Acid in Male and Female B6C3F1 MiceYear:1994Source:Environ. Health Perspect. 102(suppl.7): 93-97Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MousePHYTUMR NON(Mus musculus)INJ730. d TNOAEL: 0.498 %NR2 99.7 LAB FDOrig0.5 %Orig%7 to 9 wkPURef #105886Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fail PA;George JD;Seely JC;Grizzle TB;Heindel JJTitle:Reproductive Toxicity of Boric Acid in Swiss (CD-1) Mice: Assessment Using the ContinuousBreeding ProtocolYear:1991Source:Fundam. Appl. Toxicol. 17: 225-239Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 13 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105886Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fail PA;George JD;Seely JC;Grizzle TB;Heindel JJTitle:Reproductive Toxicity of Boric Acid in Swiss (CD-1) Mice: Assessment Using the ContinuousBreeding ProtocolYear:1991Source:Fundam. Appl. Toxicol. 17: 225-239Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseBEHFCNS NON(Mus musculus)FDB7. d TNOAEL: 108.9 ppmLOAEL: 592.02 ppm 3 >99 LAB FDOrig110 mg/kg bdwtOrig598 mg/kg bdwGE11 wkPUHouse Mouse BEH WCON NON(Mus musculus)FDB 7. d TNOAEL: 180.18 ppmLOAEL: 837.54 ppm 3 >99 LAB FDOrig182 mg/kg bdwtOrig846 mg/kg bdwGE11 wkPUHouse Mouse GRO WGHT NON(Mus musculus)MPH 189. d TLOAEL: 837.54 ppmNR3 >99 LAB FDOrig846 mg/kg bdwtOrigmg/kg bdwtGE11 wkPUHouse MouseGROWGHT NON(Mus musculus)MPH189. d TNOEL: 108.9 ppmLOEL: 592.02 ppm3 >99 LAB FDOrig110 mg/kg bdwtOrig598 mg/kg bdwGE11 wkPURef #105887Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Heindel JJ;Price CJ;Field EA;Marr MC;Myers CB;Morrisey RE;Schwetz BATitle:Developmental Toxicity of Boric Acid in Mice and RatsYear:1992Source:Fundam. Appl. Toxicol. 18: 266-277Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGROWGHT NON(Mus musculus)MPH17. d TNOAEL: 442.96 ppmLOAEL: 982.94 ppm 3 98 to 99 LAB FDOrig452 mg/kg/dOrig1003 mg/kg/dGEPUNorway Rat GRO SMIX NON(Rattus norvegicus)MPH 14. d TLOAEL: 528.22 ppmNR1 98 to 99 LAB FDOrig539 mg/kg/dOrigmg/kg/dGEPUNorway RatGROSMIX NON(Rattus norvegicus)MPH20. d TNOAEL: 76.44 ppmLOAEL: 159.74 ppm 3 98 to 99 LAB FDOrig78 mg/kg/dOrig163 mg/kg/dGEPUNorway Rat NOC NRNR NON(Rattus norvegicus)NOC 20. d TNOEL: 76.44 ppmLOEL: 159.74 ppm3 98 to 99 LAB FDOrig78 mg/kg/dOrig163 mg/kg/dGEPUMonday, June 15, 2015Page 14 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105889Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ku WW;Chapin RETitle:Mechanism of the Testicular Toxicity of Boric Acid in Rats: In Vivo and In Vitro StudiesYear:1994Source:Environ. Health Perspect. 102(suppl.7): 99-105Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBCMFLVN NON(Rattus norvegicus)BCM28. d TNOAEL: ~68 ppmNR1 100 LAB FDOrig~68 mg/kg bdwt/dOrigmg/kg bdwt/dADRef #105890Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Treinen KA;Chapin RETitle:Development of Testicular Lesions in F344 Rats After Treatment with Boric AcidYear:1991Source:Toxicol. Appl. Pharmacol. 107: 325-335Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBCMABPT NON(Rattus norvegicus)HRM4. d TLOAEL: 348.3 ppmNR1 100 LAB FDOrig348.3 mg/kg/dOrigmg/kg/dAD120 dNorway RatBCMTSTR NON(Rattus norvegicus)HRM4. d TLOAEL: 348.3 ppmNR1 100 LAB FDOrig348.3 mg/kg/dOrigmg/kg/dAD120 dRef #105891Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Harris MW;Chapin RE;Lockhart AC;Jokinen MPTitle:Assessment of a Short-Term Reproductive and Developmental Toxicity ScreenYear:1992Source:Fundam. Appl. Toxicol. 19(2): 186-196Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGROWGHT NON(Mus musculus)MPH19. d TNOAEL: 120 mg/kg bdLOAEL: 400 mg/kg bd 3 100 LAB GVOrig120 mg/kg/dOrig400 mg/kg/d14 to 16wkMonday, June 15, 2015Page 15 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105894Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Seaborn CD;Nielsen FHTitle:"Boron and Silicon: Effects on Growth, Plasma Lipids, Urinary Cyclic AMP and Bone and BrainMineral Composition of Male Rats"Year:1994Source:Environ. Toxicol. Chem. 13(6): 941-947Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBCMALPH NON(Rattus norvegicus)ENZ63. d TNOAEL: 500 ppmNR1 100 LAB FDOrig500 ug/g dietOrigug/g dietJVNorway RatBCMTRIG NON(Rattus norvegicus)BCM63. d TLOAEL: 500 ppmNR1 100 LAB FDOrig500 ug/g dietOrigug/g dietJVNorway RatGROSMIX NON(Rattus norvegicus)MPH63. d TLOAEL: 500 ppmNR1 100 LAB FDOrig500 ug/g dietOrigug/g dietJVRef #105926Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Field EA;Marr MC;Myers CBTitle:Final Report on the Developmental Toxicity of Boric Acid (CAS No. 10043-35-3) in SpragueDawley RatsYear:1990Source:NTP-90-155 : 252 p.Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBEHFCNS NON(Rattus norvegicus)FDB10. d TLOAEL: 0.784 %NR1 98 to 99 LAB FDOrig0.8 %Orig%Norway RatBEHFCNS NON(Rattus norvegicus)FDB3. d TNOAEL: 1.18 %LOAEL: 2.352 %5 98 to 99 LAB FDOrig1.2 %Orig2 %Norway RatBEHFCNS NON(Rattus norvegicus)FDB4. d TNOAEL: 0.098 %LOAEL: 0.196 %3 98 to 99 LAB FDOrig0.1 %Orig0 %Norway RatGROWGHT NON(Rattus norvegicus)MPH20. d TNOAEL: 0.392 %LOAEL: 0.784 %5 98 to 99 LAB FDOrig0.4 %Orig1 %Monday, June 15, 2015Page 16 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105927Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Field EA;Price CJ;Marr MC;Myers CBTitle:Developmental Toxicity Evaluation of Boric Acid (CAS No. 10043-35-3) Administered in Feed toCD-1 Mice on Gestational Days 0 to 17Year:1989Source:"NTP NIH Publ.No.89-250, National Inst.of Health, Res.Triangle Park, NC : 400p."Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseBEHFCNS NON(Mus musculus)FDB15. d TNOAEL: 0.392 %LOAEL: 0.784 %5 98 to 99 LAB FDOrig0.4 %Orig1 %GEPUHouse MouseBEHWCON NON(Mus musculus)FDB17. d TNOAEL: 442.96 ppmLOAEL: 982.94 ppm 3 98 to 99 LAB FDOrig452 mg/kg/dOrig1003 mg/kg/dGEPUHouse Mouse GRO SMIX NON(Mus musculus)MPH 17. d TNOAEL: 0.196 %LOAEL: 0.392 %5 98 to 99 LAB FDOrig0.2 %Orig0 %GEPUHouse MouseGROWGHT NON(Mus musculus)MPH17. d TNOAEL: 442.96 ppmLOAEL: 982.94 ppm 3 98 to 99 LAB FDOrig452 mg/kg/dOrig1003 mg/kg/dGEPURef #105930Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Marr MC;Myers CB;Shelby MD;Schwetz BATitle:"Final Report on the CNS Developmental Toxicity of Boric Acid (CAS No. 10043-35-3) inSprague-Dawley CD Rats Exposed on Gestation Days 6-15. Volume 1 of 2, Volume 2 of 2,Laboratory Supplement"Year:1994Source:"TER 93138, Research Triangle Inst., National Toxicology Program, NationalInst.Environ.Health Sci,Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBEHFCNS NR(Rattus norvegicus)FDB9. d TNOAEL: 76 ppmLOAEL: 96 ppm4 99 LAB FDOrig76 mg/kg/dOrig96 mg/kg/dGE9 wkPUNorway RatGROWGHT NR(Rattus norvegicus)MPH14. d TLOAEL: 52 ppmNR4 99 LAB FDOrig52 mg/kg/dOrigmg/kg/dGE9 wkPUNorway RatPHYHDCP NR(Rattus norvegicus)INJ14. d TLOAEL: 52 ppmNR4 99 LAB FDOrig52 mg/kg/dOrigmg/kg/dGE9 wkPUMonday, June 15, 2015Page 17 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105953Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Naghii MR;Samman STitle:The Effect of Boron on Plasma Testosterone and Plasma Lipids in RatsYear:1997Source:Nutr. Res. 17(3): 523-531Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBCMTSTR NON(Rattus norvegicus)HRM28. d TLOAEL: 2 mg/org/dNR1 100 LAB DR 6.5 to 7Orig2 mg/org/dOrigmg/org/dADNorway RatBCMVTMD NON(Rattus norvegicus)BCM14. d TLOAEL: 2 mg/org/dNR1 100 LAB DR 6.5 to 7Orig2 mg/org/dOrigmg/org/dADNorway RatGROWGHT NON(Rattus norvegicus)MPH28. d TNOAEL: 2 mg/org/dNR1 100 LAB DR 6.5 to 7Orig2 mg/org/dOrigmg/org/dADRef #105972Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Chapin RE;Ku WW;Kenney MA;McCoy HTitle:The Effects of Dietary Boric Acid on Bone Strength in RatsYear:1998Source:Biol. Trace Elem. Res. 66(1-3): 395-399Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBCMPCON NON(Rattus norvegicus)BCM84. d TLOAEL: 1.7 ppmNR4 100 LAB FDOrig1.7 mg/kg/dOrigmg/kg/dADNorway RatPHYBNDS NON(Rattus norvegicus)PHY84. d TNOAEL: 68 ppmNR4 100 LAB FDOrig68 mg/kg/dOrigmg/kg/dADRef #105977Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fukuda R;Hirode M;Mori I;Chatani F;Morishima H;Mayahara HTitle:Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated DoseStudies in Rats 24) Testicular Toxicity of Boric Acid After 2- and 4-Week Administration PeriodsYear:2000Source:J. Toxicol. Sci. 25: 233-239Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 18 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105977Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fukuda R;Hirode M;Mori I;Chatani F;Morishima H;Mayahara HTitle:Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated DoseStudies in Rats 24) Testicular Toxicity of Boric Acid After 2- and 4-Week Administration PeriodsYear:2000Source:J. Toxicol. Sci. 25: 233-239Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)MPH28. d TLOAEL: 497.5 mg/kg bNR2 >99.5 LAB GVOrig500 mg/kg/dOrigmg/kg/d5 wkRef #105982Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kudo S;Tanase H;Yamasaki M;Nakao M;Miyata Y;Tsuru K;Imai STitle:Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated DoseStudies in Rats 23). A Comparative 2- and 4-Week Repeated Oral Dose Testicular ToxicityStudy of Boric Acid in RatsYear:2000Source:J. Toxicol. Sci. 25: 223-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)MPH28. d TNOAEL: 496.2 mg/kg bNR3 99.24 LAB GVOrig500 mg/kgOrigmg/kg6 wkPURef #105983Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Strong PL;Murray FJ;Goldberg MMTitle:Developmental Effects of Boric Acid in Rats Related to Maternal Blood Boron ConcentrationsYear:1998Source:Biol. Trace Elem. Res. 66(1-3): 359-372Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatACCRSDE NON(Rattus norvegicus)ACC20. d TLOAEL: 3 ppmNR5 >98 LAB FDOrig3 mg/kg/dOrigmg/kg/dGEPUMonday, June 15, 2015Page 19 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105986Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Wery N;Narotsky MG;Pacico N;Kavlock RJ;Picard JJ;Gofflot FTitle:Defects in Cervical Vertebrae in Boric Acid-Exposed Rat Embryos are Associated with AnteriorShifts of hox Gene Expression DomainsYear:2003Source:Birth Defects Res. A Clin. Mol. Teratol. 67(1): 59-67Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatCELGEXP NON(Rattus norvegicus)GEN4.5 d TLOAEL: 500 mg/kg bdwNR1 100 LAB GVOrig500 mg/kgOrigmg/kgRef #105987Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yoshizaki H;Izumi Y;Hirayama C;Fujimoto A;Kandori H;Sugitani T;Ooshima YTitle:Availability of Sperm Examination for Male Reproductive Toxicities in Rats Treated with BoricAcidYear:1999Source:J. Toxicol. Sci. 24(3): 199-208Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROABNM NON(Rattus norvegicus)MPH21. d TNOAEL: 49.75 mg/kg bLOAEL: 149.25 mg/kg 3 99.5 LAB GVOrig50 mg/kg/dOrig150 mg/kg/d11 wkNorway Rat GRO SMIX NON(Rattus norvegicus)MPH 21. d TNOAEL: 149.25 mg/kgLOAEL: 497.5 mg/kg b 3 99.5 LAB GVOrig150 mg/kg/dOrig500 mg/kg/d11 wkRef #106331Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Wang Y;Zhao Y;Chen XTitle:Experimental Study on the Estrogen-Like Effect of Boric AcidYear:2008Source:Biol. Trace Elem. Res. 121(2): 160-170Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBCMESDL NON(Rattus norvegicus)HRM3. d TNOAEL: 75 mg/kg bdwtNR3 100 LAB GVOrig75 mg/kgOrigmg/kgADNorway RatBCMESDL NON(Rattus norvegicus)HRM4. d TNOAEL: 75 mg/kg bdwtNR3 100 LAB GVOrig75 mg/kgOrigmg/kgADMonday, June 15, 2015Page 20 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106331Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Wang Y;Zhao Y;Chen XTitle:Experimental Study on the Estrogen-Like Effect of Boric AcidYear:2008Source:Biol. Trace Elem. Res. 121(2): 160-170Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatCELESRS NON(Rattus norvegicus)CEL3. d TLOAEL: 4 mg/kg bdwtNR3 100 LAB GVOrig4 mg/kgOrigmg/kgADNorway RatCELHGHT NON(Rattus norvegicus)CEL4. d TLOAEL: 4 mg/kg bdwtNR3 100 LAB GVOrig4 mg/kgOrigmg/kgADNorway RatCELPCNA NON(Rattus norvegicus)GEN4. d TNOAEL: 25 mg/kg bdwtLOAEL: 75 mg/kg bdw 3 100 LAB GVOrig25 mg/kgOrig75 mg/kgADNorway Rat GRO SMIX NON(Rattus norvegicus)MPH 4. d TNOAEL: 25 mg/kg bdwtLOAEL: 75 mg/kg bdw 3 100 LAB GVOrig25 mg/kgOrig75 mg/kgADRef #106607Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Linder RE;Strader LF;Slott VL;Suarez JDTitle:Endpoints of Spermatotoxicity in the Rat After Short Duration Exposures to FourteenReproductive ToxicantsYear:1992Source:Reprod. Toxicol. 6(6): 491-505Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROWGHT NON(Rattus norvegicus)MPH2. d TLOAEL: 20 mg/kg bdwtNR1 100 LAB GVOrig20 mg/kgOrigmg/kg102 to103 dRef #106608Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ku WW;Chapin RE;Wine RN;Gladen BCTitle:Testicular Toxicity of Boric Acid (BA): Relationship of Dose to Lesion Development and Recoveryin the F344 RatYear:1993Source:Reprod. Toxicol. 7: 305-319Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 21 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106608Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ku WW;Chapin RE;Wine RN;Gladen BCTitle:Testicular Toxicity of Boric Acid (BA): Relationship of Dose to Lesion Development and Recoveryin the F344 RatYear:1993Source:Reprod. Toxicol. 7: 305-319Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatACCRSDE NON(Rattus norvegicus)ACC7. d TLOAEL: 26 ppmNR4 99.99 LAB FDOrig26 mg/kg bdwt/dOrigmg/kg bdwt/dAD70 to 80 dPUNorway RatBCMFOSH NON(Rattus norvegicus)HRM168. d TLOAEL: 38 ppmNR4 99.99 LAB FDOrig38 mg/kg bdwt/dOrigmg/kg bdwt/dAD70 to 80 dPUNorway RatCELATPH NON(Rattus norvegicus)HIS21. d TNOAEL: 38 ppmLOAEL: 52 ppm4 99.99 LAB FDOrig38 mg/kg bdwt/dOrig52 mg/kg bdwt/AD70 to 80 dPURef #106613Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fail PA;George JD;Sauls HR;Dennis SW;Seely JCTitle:Effect of Boric Acid on Reproduction and Fertility of RodentsYear:1989Source:Adv. Contracept. Deliv. Syst. 5: 323-333Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Deer MouseCELNCEL NON(Peromyscus maniculatus)CEL56. d TNOAEL: 4500 ppmLOAEL: 9000 ppm2 100 LAB FDOrig4500 ppmOrig9000 ppmAD10 wkDeer MouseGROWGHT NON(Peromyscus maniculatus)MPH56. d TNOAEL: 4500 ppmLOAEL: 9000 ppm2 100 LAB FDOrig4500 ppmOrig9000 ppmAD10 wkHouse MouseCELNCEL NON(Mus musculus)CEL189. d TNOAEL: 1000 ppmLOAEL: 4500 ppm3 100 LAB FDOrig1000 ppmOrig4500 ppmADHouse MouseGROWGHT NON(Mus musculus)MPH189. d TNOAEL: 1000 ppmLOAEL: 4500 ppm3 100 LAB FDOrig1000 ppmOrig4500 ppmADMonday, June 15, 2015Page 22 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #107029Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Settimi L;Elovaara E;Savolainen HTitle:Effects of Extended Peroral Borate Ingestion on Rat Liver and BrainYear:1982Source:Toxicol. Lett. 10: 219-223Test Chemical:Boron sodium oxide (B4Na2O7)CAS Number:1330434Lifestage:AgeFormul.Norway RatBCMSCDH NON(Rattus norvegicus)ENZ70. d TLOAEL: 3000 ppmNR1 100 LAB DROrig3 g/LOrigg/L2 moNorway RatCELRNAC NON(Rattus norvegicus)GEN98. d TLOAEL: 3000 ppmNR1 100 LAB DROrig3 g/LOrigg/L2 moRef #107074Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ban Y;Naya M;Nishimura T;Kaneto M;Kishi K;Inoue T;Yoshizaki H;Ooshima YTitle:Collaborative Study on Rat Sperm Motion Analysis Using Cellsoft Series 4000 Semen AnalyzerYear:2001Source:J. Toxicol. Sci. 26(1): 9-24Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatGROSMIX NON(Rattus norvegicus)MPH21. d TNOAEL: 150 mg/kg bdLOAEL: 500 mg/kg bd 3 100 LAB GVOrig150 mg/kg/dOrig500 mg/kg/dSMRef #107075Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cherrington JW;Chernoff NTitle:Periods of Vertebral Column Sensitivity to Boric Acid Treatment in CD-1 Mice In UteroYear:2002Source:Reprod. Toxicol. 16(3): 237-243Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseCELXCPH NON(Mus musculus)HIS10. d TLOAEL: 742.5 mg/kg bNR1 99 LAB GVOrig750 mg/kgOrigmg/kgGEPUHouse MouseCELXCPH NON(Mus musculus)HIS9.5 d TNOAEL: 742.5 mg/kg bNR1 99 LAB GVOrig750 mg/kgOrigmg/kgGEPUMonday, June 15, 2015Page 23 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #107075Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cherrington JW;Chernoff NTitle:Periods of Vertebral Column Sensitivity to Boric Acid Treatment in CD-1 Mice In UteroYear:2002Source:Reprod. Toxicol. 16(3): 237-243Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseGROFORM NON(Mus musculus)DVP12. d TLOAEL: 495 mg/kg bdwNR2 99 LAB GVOrig500 mg/kg/dOrigmg/kg/dGEPURef #107077Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Strong PL;Murray FJ;Goldberg MMTitle:Blood Boron Concentrations in Pregnant Rats Fed Boric Acid Throughout GestationYear:1997Source:Reprod. Toxicol. 11(6): 833-842Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatACCRSDE NON(Rattus norvegicus)ACC20. d TLOAEL: 3.3 ppmNR5 98 to 99 LAB FDOrig3.3 mg/kg/dOrigmg/kg/dGEPURef #118903Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Magour S;Schramel P;Ovcar J;Maser HTitle:Uptake and Distribution of Boron in Rats: Interaction with Ethanol and Hexobarbital in the BrainYear:1982Source:Arch. Environ. Contam. Toxicol. 11: 521-525Test Chemical:Boron sodium oxide (B4Na2O7)CAS Number:1330434Lifestage:AgeFormul.Norway RatBEHINST NON(Rattus norvegicus)BEH8. d TLOAEL: 20 ppmNR1 100 LAB DROrig20 mg/kg/dOrigmg/kg/d3 to 4 wkMonday, June 15, 2015Page 24 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #151804Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:National Toxicology Program (NTP)Title:Final Report on the Developmental Toxicity of Boric Acid (CAS No.10043-35-3) in CD-1-SwissMiceYear:1989Source:"NTP Report # 89-250, Research Triangle Park, NC : 394 p."Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.House MouseBEHFCNS NON(Mus musculus)FDBd TNOAEL: 442.47 ppmLOAEL: 982.94 ppm 1 98 to 99 LAB FDOrig451.5 mg/kg/dOrig1003 mg/kg/dGE0 dgePUHouse Mouse BEH WCON NON(Mus musculus)FDB 17. d TNOAEL: 0.196 %LOAEL: 0.392 %1 98 to 99 LAB FDOrig0.2 %Orig0 %GE0 dgePUHouse MouseGROSMIX NON(Mus musculus)MPH17. d TNOAEL: 0.196 %LOAEL: 0.392 %1 98 to 99 LAB FDOrig0.2 %Orig0 %GE0 dgePUHouse MouseGROWGHT NON(Mus musculus)MPH17. d TNOAEL: 442.47 ppmLOAEL: 982.94 ppm 1 98 to 99 LAB FDOrig451.5 mg/kg/dOrig1003 mg/kg/dGE0 dgePURef #152668Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Chapin RE;Ku WW;Kenney MA;McCoy H;Gladen B;Wine RN;Wilson R;Elwell MRTitle:The Effects of Dietary Boron on Bone Strength in RatsYear:1997Source:Fundam. Appl. Toxicol. 35(2): 205-215Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatACCRSDE NR(Rattus norvegicus)ACC7. d TLOAEL: 545 ppmNR1 99.99 LAB FDOrig545 ppmOrigppmYA60 to 70 dPUNorway RatACCRSDE NR(Rattus norvegicus)ACC7. d TLOAEL: 199.98 ppmNR1 99.99 LAB FDOrig200 ppmOrigppmYA60 to 70 dPUNorway RatBCMPCON NR(Rattus norvegicus)BCM84. d TLOAEL: 199.98 ppmNR1 99.99 LAB FDOrig200 ppmOrigppmYA60 to 70 dPUNorway RatBCMPCON NR(Rattus norvegicus)BCM63. d TLOAEL: 545 ppmNR1 99.99 LAB FDOrig545 ppmOrigppmYA60 to 70 dPUMonday, June 15, 2015Page 25 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #152668Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Chapin RE;Ku WW;Kenney MA;McCoy H;Gladen B;Wine RN;Wilson R;Elwell MRTitle:The Effects of Dietary Boron on Bone Strength in RatsYear:1997Source:Fundam. Appl. Toxicol. 35(2): 205-215Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatPHYBNDS NR(Rattus norvegicus)PHY84. d TLOAEL: 199.98 ppmNR1 99.99 LAB FDOrig200 ppmOrigppmYA60 to 70 dPUNorway RatPHYBNDS NR(Rattus norvegicus)PHY35. d TNOAEL: 8999.1 ppmNR1 99.99 LAB FDOrig9000 ppmOrigppmYA60 to 70 dPURef #166774Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ince S;Kucukkurt I;Cigerci IH;Fidan AF;Eryavuz ATitle:"The Effects of Dietary Boric Acid and Borax Supplementation on Lipid Peroxidation, AntioxidantActivity, and DNA Damage in Rats"Year:2010Source:J. Trace Elem. Med. Biol. 24(3): 161-164Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Norway RatBCMMLDH NON(Rattus norvegicus)BCM28. d TLOAEL: 100 ppmNR1 100 LAB FDOrig100 mg/kg dietOrigmg/kg dietNorway RatBCMMLDH NON(Rattus norvegicus)BCM28. d TLOAEL: 100 ppmNR1 100 LAB FDOrig100 mg/kg dietOrigmg/kg dietNorway RatBCMSODA NON(Rattus norvegicus)ENZ28. d TLOAEL: 100 ppmNR1 100 LAB FDOrig100 mg/kg dietOrigmg/kg dietNorway RatBCMSODA NON(Rattus norvegicus)ENZ28. d TLOAEL: 100 ppmNR1 100 LAB FDOrig100 mg/kg dietOrigmg/kg dietNorway RatCELDAMG NON(Rattus norvegicus)GEN28. d TLOAEL: 100 ppmNR1 100 LAB FDOrig100 mg/kg dietOrigmg/kg dietNorway RatCELDAMG NON(Rattus norvegicus)GEN28. d TLOAEL: 100 ppmNR1 100 LAB FDOrig100 mg/kg dietOrigmg/kg dietMonday, June 15, 2015Page 26 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.HoneybeeTaxa_Code:BEEOtherRef #81711Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Mayer DF;Lunden JD;Kovacs G;Miliczky ERTitle:Field Evaluation of Non-Pesticide Chemicals as Honey Bee RepellentsYear:2001Source:"In: L.P.Elzunces, C.Elissier, & G.B.Lewis (Eds.), Hazards of Pesticides toBees, Institute NationalTest Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Honey BeeBEHCHEM NON(Apis mellifera)AVO0.167 d TNOAEL: 50000 ppmNR3 100 FIELDN HSOrig50 g/LOrigg/LHoney BeeBEHCHEM NON(Apis mellifera)AVO0.042 d TNOAEL: 50000 ppmNR3 100 FIELDN HSOrig50 g/LOrigg/LRef #157981Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Da Silva Cruz A;Da Silva-Zacarin ECM;Bueno OC;Malaspina OTitle:Morphological Alterations Induced by Boric Acid and Fipronil in the Midgut of Worker Honeybee(Apis mellifera L.) Larvae. Morphological Alterations in the Midgut of A. melliferaYear:2010Source:Cell Biol. Toxicol. 26(2): 165-176Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.Honey BeeMORMDTH NR(Apis mellifera)MORd TLOAEL: 1 mg/g fdNR3 100 LAB FDOrig1 mg/g fdOrigmg/g fdLV1 insRef #166396Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ferreira RAC;Zacarin ECMS;Malaspina O;Bueno OC;Tomotake MEM;Pereira AMTitle:"Cellular Responses in the Malpighian Tubules of Scaptotrigona postica (Latreille, 1807)Exposed to Low Doses of Fipronil and Boric Acid"Year:2013Source:Micron 46: 57-65Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 27 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166396Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ferreira RAC;Zacarin ECMS;Malaspina O;Bueno OC;Tomotake MEM;Pereira AMTitle:"Cellular Responses in the Malpighian Tubules of Scaptotrigona postica (Latreille, 1807)Exposed to Low Doses of Fipronil and Boric Acid"Year:2013Source:Micron 46: 57-65Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Stingless BeeMORSURV NR(Scaptotrigona postica)MOR10. d TLOAEL: 0.75 ug/d/orgNR1 100 LAB FDOrig0.75 ug/d/orgOrigug/d/orgNH4 dOther terrestrial animalsTaxa_Code:OTAOtherRef #59516Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Greenberg L;Amrhein C;Rust MKTitle:Toxicity and Repellency of Borate-Sucrose Water Baits to Argentine Ants (Hymenoptera:Formicidae)Year:2000Source:J. Econ. Entomol. 93(4): 1256-1258Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntBEHFCNS MIX(Linepithema humile)FDB24. d TNOAEL: 3.96 %NR4 99 LAB ENOrig4 %Orig%CRYArgentine AntMORMORT MIX(Linepithema humile)MOR1.3 d TLT50: 0.99 %NR1 99 LAB ENOrig1 %Orig%CRYArgentine AntMORMORT MIX(Linepithema humile)MOR2.2 d TLT50: 0.495 %NR1 99 LAB ENOrig0.5 %Orig%CRYArgentine AntMORMORT MIX(Linepithema humile)MOR1.2 d TLT50: 0.99 %NR1 99 LAB ENOrig1 %Orig%CRYArgentine AntMORMORT MIX(Linepithema humile)MOR2.4 d TLT50: 0.495 %NR1 99 LAB ENOrig0.5 %Orig%CRYMonday, June 15, 2015Page 28 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #59516Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Greenberg L;Amrhein C;Rust MKTitle:Toxicity and Repellency of Borate-Sucrose Water Baits to Argentine Ants (Hymenoptera:Formicidae)Year:2000Source:J. Econ. Entomol. 93(4): 1256-1258Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntMORMORT MIX(Linepithema humile)MOR2.3 d TLT50: 0.495 %NR1 99 LAB ENOrig0.5 %Orig%CRYArgentine AntMORMORT MIX(Linepithema humile)MOR1.1 d TLT50: 0.99 %NR1 99 LAB ENOrig1 %Orig%CRYRef #81004Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Green GH;Weeth HJTitle:Response of Heifers Ingesting Boron in WaterYear:1977Source:J. Anim. Sci. 46(4): 812-818Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Domesticated CattleACCRSDE NON(Bos taurus)ACC30. d TLOAEL: 4224 mg/dNR2 100 FIELDA DROrig4224 mg/dOrigmg/dDomesticated CattleBCMHMCT NON(Bos taurus)BCM30. d TLOAEL: 4224 mg/dNR2 100 FIELDA DROrig4224 mg/dOrigmg/dDomesticated CattleBEHFCNS NON(Bos taurus)FDB30. d TLOAEL: 4224 mg/dNR2 100 FIELDA DROrig4224 mg/dOrigmg/dDomesticated CattlePHYNAEX NON(Bos taurus)PHY30. d TLOAEL: 4224 mg/dNR2 100 FIELDA DROrig4224 mg/dOrigmg/dMonday, June 15, 2015Page 29 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #99279Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Grace JKTitle:Response of Eastern and Formosan Subterranean Termites (Isoptera: Rhinotermitidae) toBorate Dust and Soil TreatmentsYear:1991Source:J. Econ. Entomol. 84(6): 1753-1757Test Chemical:Boron sodium oxide(B8Na2O13) tetrahydrateCAS Number:12280034Lifestage:AgeFormul.Eastern Subterranean TermiteBEHBBBH NAT(Reticulitermes flavipes)BEH10. d TNOAEL: 15000 ppmNR3 100 LAB ENOrig15000 ppmOrigppmPOEastern Subterranean TermiteMORMORT NAT(Reticulitermes flavipes)MOR15. d TLOAEL: 20.96 %NR1 100 LAB TPOrig20.96 %Orig%POEastern Subterranean TermiteMORMORT NAT(Reticulitermes flavipes)MOR10. d TLOAEL: 5000 ppmNR3 100 LAB ENOrig5000 ppmOrigppmPOFormosan Subterranean TermiteBEHBBBH NAT(Coptotermes formosanus)BEH10. d TNOAEL: 15000 ppmNR3 100 LAB ENOrig15000 ppmOrigppmPOFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR15. d TLOAEL: 20.96 %NR1 100 LAB TPOrig20.96 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR15. d TLOAEL: 20.96 %NR1 100 LAB TPOrig20.96 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR15. d TLOAEL: 17.48 %NR1 99 LAB TPOrig17.48 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR8. d TLOAEL: 20.96 %NR1 100 LAB TPOrig20.96 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR4. d TLOAEL: 20.96 %NR1 100 LAB TPOrig20.96 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR15. d TLOAEL: 17.48 %NR1 99 LAB TPOrig17.48 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR4. d TLOAEL: 17.48 %NR1 99 LAB TPOrig17.48 %Orig%POMonday, June 15, 2015Page 30 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #99279Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Grace JKTitle:Response of Eastern and Formosan Subterranean Termites (Isoptera: Rhinotermitidae) toBorate Dust and Soil TreatmentsYear:1991Source:J. Econ. Entomol. 84(6): 1753-1757Test Chemical:Boron sodium oxide(B8Na2O13) tetrahydrateCAS Number:12280034Lifestage:AgeFormul.Formosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR8. d TLOAEL: 17.48 %NR1 99 LAB TPOrig17.48 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR15. d TLOAEL: 20.96 %NR1 100 LAB TPOrig20.96 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR2. d TNOAEL: 20.96 %NR1 100 LAB TPOrig20.96 %Orig%POFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR10. d TNOAEL: 15000 ppmNR3 100 LAB ENOrig15000 ppmOrigppmPOFormosan Subterranean TermiteMORMORT NAT(Coptotermes formosanus)MOR2. d TNOAEL: 17.48 %NR1 99 LAB TPOrig17.48 %Orig%PORef #99749Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Knight RL;Rust MKTitle:Repellency and Efficacy of Insecticides Against Foraging Workers in Laboratory Colonies ofArgentine Ants (Hymenoptera: Formicidae)Year:1990Source:J. Econ. Entomol. 83(4): 1402-1408Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntBEHCHEM NR(Linepithema humile)AVO0.042 d TNOAEL: 35000 AI mg/NR1 100 LAB DAOrig35000 AI mg/m2OrigAI mg/m2TCMonday, June 15, 2015Page 31 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #101951Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rust MK;Reierson DA;Klotz JHTitle:Delayed Toxicity as a Critical Factor in the Efficacy of Aqueous Baits for Controlling ArgentineAnts (Hymenoptera: Formicidae)Year:2004Source:J. Econ. Entomol. 97(3): 1017-1024Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntBEHFCNS NON(Linepithema humile)FDB4. d TNOAEL: 4.95 %NR6 99 LAB DROrig5 %Orig%PURef #102851Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Amorim MJB;Novais S;Rombke J;Soares AMVMTitle:Enchytraeus albidus (Enchytraeidae): A Test Organism in a Standardised Avoidance Test?Effects of Different Chemical SubstancesYear:2008Source:Environ. Int. 34(3): 363-371Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.PotwormBEHCHEM ART(Enchytraeus albidus)AVO2. d TEC50: >1996 ppmNR5 99.8 LAB DA 5.5*Orig>2000 AI mg/kg soiOrigAI mg/kg soilPURef #105240Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Weir RJ;Jr;Fisher RSTitle:Toxicologic Studies on Borax and Boric AcidYear:1972Source:Toxicol. Appl. Pharmacol. 23: 351-364Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic DogGROSMIX NON(Canis familiaris)MPH90. d TLOAEL: 1750 ppmNR3 100 LAB FDOrig1750 ppmOrigppmDomestic DogGROSMIX NON(Canis familiaris)MPH90. d TLOAEL: 1750 ppmNR3 100 LAB FDOrig1750 ppmOrigppmDomestic DogGROSMIX NON(Canis familiaris)MPH90. d TLOAEL: 1750 ppmNR3 100 LAB FDOrig1750 ppmOrigppmMonday, June 15, 2015Page 32 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105240Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Weir RJ;Jr;Fisher RSTitle:Toxicologic Studies on Borax and Boric AcidYear:1972Source:Toxicol. Appl. Pharmacol. 23: 351-364Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Domestic DogGROWGHT NON(Canis familiaris)MPH90. d TLOAEL: 1750 ppmNR3 100 LAB FDOrig1750 ppmOrigppmRef #105931Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Marr MC;Myers CB;Heindel JJ;Schwetz BATitle:Developmental Toxicity Evaluation of Boric Acid (CAS No. 10043-35-3) Administered to NewZealand White Rabbits by Gavage on Gestational Days 6 Through 19 (Final Study Report andAppendix)Year:1991Source:"Final Rep. TER90003, Natl. Toxicol. Prog. (NTP), Research Triangle Park,NC,NTP Final Study Rep. 7:Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.European RabbitPHYDAMG NON(Oryctolagus cuniculus)INJ14. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d5.5 moRef #105980Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Jose VT;Rajalakshmy VK;Jayarathnam K;Nehru CRTitle:Chemical Mixtures for Rubber Wood Treatment by Diffusion ProcessYear:1995Source:Indian J. Nat. Rubber Res. 8(1): 25-30Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Island Pinhole BorerPOPCNTL NON(Xyleborus perforans)POP1095. d TNOAEL: 7.5 %NR1 100 FIELDN ENOrig7.5 %Orig%Oriental Wood BorerPOPCNTL NON(Heterobostrychus aequalis)POP1095. d TLOAEL: 7.5 %NR1 100 FIELDN ENOrig7.5 %Orig%Monday, June 15, 2015Page 33 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106171Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:US Borax and Chemical CorpTitle:Initial Submission: Developmental Toxicity of Boric Acid in New Zealand White Rabbits (FinalReport) with Attachments and Cover Letter Dated 010692Year:1992Source:EPA/OTS Doc.#88-920000648 : 186 p.Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.European RabbitBEHFCNS NON(Oryctolagus cuniculus)FDB14. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d~5.5 moEuropean Rabbit GRO SMIX NON(Oryctolagus cuniculus)MPH 14. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d~5.5 moRef #106689Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz J;Greenberg L;Venn ECTitle:Liquid Boric Acid Bait for Control of the Argentine Ant (Hymenoptera: Formicidae)Year:1998Source:J. Econ. Entomol. 91(4): 910-914Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntPOPABND NON(Linepithema humile)POP70. d TLOAEL: 0.495 %NR1 99 FIELDN CMOrig0.5 %Orig%CRYRef #106690Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Oi DH;Vail KM;Williams DFTitle:Laboratory Evaluation of a Boric Acid Liquid Bait on Colonies of Tapinoma melanocephalumArgentine Ants and Pharaoh Ants (Hymenoptera: Formicidae)Year:1996Source:J. Econ. Entomol. 89(3): 673-677Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntPOPABND NON(Linepithema humile)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYArgentine AntPOPABND NON(Linepithema humile)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYMonday, June 15, 2015Page 34 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106690Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Oi DH;Vail KM;Williams DFTitle:Laboratory Evaluation of a Boric Acid Liquid Bait on Colonies of Tapinoma melanocephalumArgentine Ants and Pharaoh Ants (Hymenoptera: Formicidae)Year:1996Source:J. Econ. Entomol. 89(3): 673-677Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntPOPABND NON(Linepithema humile)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYArgentine AntPOPABND NON(Linepithema humile)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYGhost AntPOPABND NON(Tapinoma melanocephalum)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYGhost AntPOPABND NON(Tapinoma melanocephalum)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYGhost AntPOPABND NON(Tapinoma melanocephalum)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYGhost AntPOPABND NON(Tapinoma melanocephalum)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYPharoah AntPOPABND NON(Monomorium pharaonis)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYPharoah AntPOPABND NON(Monomorium pharaonis)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYPharoah AntPOPABND NON(Monomorium pharaonis)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYPharoah AntPOPABND NON(Monomorium pharaonis)POP70. d TLOAEL: 0.99 %NR1 99 LAB DROrig1 %Orig%CRYMonday, June 15, 2015Page 35 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106710Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Klotz JH;Vail KM;Williams DFTitle:Liquid Boric Acid Bait for Control of Structural Infestations of Pharaoh Ants (Hymenoptera:Formicidae)Year:1997Source:J. Econ. Entomol. 90(2): 523-526Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Pharoah AntPOPABND NR(Monomorium pharaonis)POP7. d TLOAEL: 0.99 %NR1 99 FIELDA FDOrig1 %Orig%AIPharoah AntPOPABND NR(Monomorium pharaonis)POP7. d TLOAEL: 0.99 %NR1 99 FIELDA FDOrig1 %Orig%AIRef #106729Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Stanley MC;Robinson WATitle:Relative Attractiveness of Baits to Paratrechina longicornis (Hymenoptera: Formicidae)Year:2007Source:J. Econ. Entomol. 100(2): 509-516Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Crazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.083 d TNOAEL: 1 %NR1 100 FIELDN ENOrig1 %Orig%Crazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.083 d TNOAEL: 1 %NR1 100 FIELDN ENOrig1 %Orig%Crazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.042 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.083 d TNOAEL: 1 %NR1 100 FIELDN ENOrig1 %Orig%Crazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.083 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.028 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUMonday, June 15, 2015Page 36 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106729Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Stanley MC;Robinson WATitle:Relative Attractiveness of Baits to Paratrechina longicornis (Hymenoptera: Formicidae)Year:2007Source:J. Econ. Entomol. 100(2): 509-516Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Crazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.083 d TNOAEL: 1 %NR1 100 FIELDN ENOrig1 %Orig%Crazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.063 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.056 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.083 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.111 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.021 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.028 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.056 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.021 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUCrazy AntBEHCHEM NON(Paratrechina longicornis)AVO0.042 d TNOAEL: 0.995 %NR1 99.5 FIELDN ENOrig1 %Orig%PUMonday, June 15, 2015Page 37 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #107048Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Price CJ;Marr MC;Myers CB;Seely JC;Heindel JJ;Schwetz BATitle:The Developmental Toxicity of Boric Acid in RabbitsYear:1996Source:Fundam. Appl. Toxicol. 34(2): 176-187Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.European RabbitBEHFCNS NON(Oryctolagus cuniculus)FDB14. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d5.5 moEuropean Rabbit GRO WGHT NON(Oryctolagus cuniculus)MPH 14. d TNOAEL: 123.75 mg/kgLOAEL: 247.5 mg/kg b 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d5.5 moEuropean Rabbit NOC MULT NON(Oryctolagus cuniculus)NOC 14. d TNOEL: 123.75 mg/kg bLOEL: 247.5 mg/kg bd 3 99 LAB GVOrig125 mg/kg/dOrig250 mg/kg/d5.5 moRef #107076Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Daane KM;Cooper ML;Sime KR;Nelson EH;Battany MC;Rust MKTitle:Testing Baits to Control Argentine Ants (Hymenoptera: Formicidae) in VineyardsYear:2008Source:J. Econ. Entomol. 101(3): 699-709Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Argentine AntPOPABND NAT(Linepithema humile)POPgs TLOAEL: 0.5 % w/vNR1 100 FIELDN DROrig0.5 % w/vOrig% w/vCRYArgentine AntPOPABND NAT(Linepithema humile)POPgs TLOAEL: 0.5 % w/vNR1 100 FIELDN DROrig0.5 % w/vOrig% w/vCRYBrown ScalePOPABND NAT(NR Parthenolecanium corni ssp. co)POPgs TNOAEL: 0.5 % w/vNR1 100 FIELDN DROrig0.5 % w/vOrig% w/vCRYObscure MealybugPOPABND NAT(Pseudococcus viburni)POPgs TLOAEL: 0.5 % w/vNR1 100 FIELDN DROrig0.5 % w/vOrig% w/vCRYMonday, June 15, 2015Page 38 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #118127Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Baker JMTitle:The Insecticidal Action of Some Components of Wood PreservativesYear:1972Source:Pestic. Sci. 3(2): 229-239Test Chemical:Boron sodium oxide (B8Na2O13)CAS Number:12008412Lifestage:AgeFormul.Furniture BeetleMORMORT LIT(Anobium punctatum)MOR<=365. d TLC50: 1200 ppmNR100 LAB ENOrig1.2 kg/m3Origkg/m3LVRef #120915Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Garcia CM;Morrell JJTitle:Efficacy and Economic Benefits of Prophylactic Treatments of Newly Felled BambooYear:2010Source:J. Econ. Entomol. 103(1): 101-107Test Chemical:Boron sodium oxide(B8Na2O13) tetrahydrateCAS Number:12280034Lifestage:AgeFormul.Bamboo Powderpost BeetlePOPABND NR(Dinoderus minutus)POP7. d TLOAEL: 19.88 AI %NR1 100 LAB SPOrig19.88 AI %OrigAI %ADAIBamboo Powderpost BeetlePOPABND NR(Dinoderus minutus)POP7. d TLOAEL: 19.88 AI %NR1 100 LAB SPOrig19.88 AI %OrigAI %ADAIRef #153536Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Chang VTitle:Toxic Baiting of the Western Yellowjacket (Hymenoptera: Vespidae) in HawaiiYear:1988Source:J. Econ. Entomol. 81(1): 228-235Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.Western YellowjacketBEHFCNS NON(Vespula pensylvanica)FDB91.32 d TLOAEL: 14410 AI mgNR1 100 FIELDN FDOrig14410 AI mgOrigAI mgMonday, June 15, 2015Page 39 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166197Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hyrsl P;Buyukguzel E;Buyukguzel KTitle:The Effects of Boric Acid-Induced Oxidative Stress on Antioxidant Enzymes and Survivorship inGalleria mellonellaYear:2007Source:Arch. Insect Biochem. Physiol. 66(1): 23-31Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Greater Wax MothBCMCTLS NR(Galleria mellonella)ENZ<37. d TLOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV1 insPUGreater Wax MothBCMCTLS NR(Galleria mellonella)ENZ<28. d TLOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV1 insPUGreater Wax MothBCMMLDH NR(Galleria mellonella)BCM<37. d TLOAEL: 613.8 ppmNR1 99 LAB FDOrig620 ppmOrigppmLV1 insPUGreater Wax MothBCMMLDH NR(Galleria mellonella)BCM<28. d TLOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV1 insPUGreater Wax MothBCMMLDH NR(Galleria mellonella)BCM<37. d TNOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV1 insPUGreater Wax MothMORLFSP NR(Galleria mellonella)MOR<43. d TLOAEL: 613.8 ppmNR1 99 LAB FDOrig620 ppmOrigppmLV1 insPUGreater Wax MothMORLFSP NR(Galleria mellonella)MOR<43. d TNOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV1 insPUGreater Wax MothMORSURV NR(Galleria mellonella)MOR<28. d TLOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV1 insPUGreater Wax MothMORSURV NR(Galleria mellonella)MOR<43. d TLOAEL: 1237.5 ppmNR1 99 LAB FDOrig1250 ppmOrigppmLV1 insPUGreater Wax MothMORSURV NR(Galleria mellonella)MOR<37. d TLOAEL: 613.8 ppmNR1 99 LAB FDOrig620 ppmOrigppmLV1 insPUGreater Wax MothMORSURV NR(Galleria mellonella)MOR<43. d TNOAEL: 613.8 ppmNR1 99 LAB FDOrig620 ppmOrigppmLV1 insPUMonday, June 15, 2015Page 40 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166197Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hyrsl P;Buyukguzel E;Buyukguzel KTitle:The Effects of Boric Acid-Induced Oxidative Stress on Antioxidant Enzymes and Survivorship inGalleria mellonellaYear:2007Source:Arch. Insect Biochem. Physiol. 66(1): 23-31Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Greater Wax MothMORSURV NR(Galleria mellonella)MOR<37. d TNOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV1 insPURef #166346Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kartal SN;Ayrilmis N;Imamura YTitle:Decay and Termite Resistance of Plywood Treated with Various Fire RetardantsYear:2007Source:Build. Environ. 42(3): 1207-1211Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Formosan Subterranean TermitePOPABND LIT(Coptotermes formosanus)POP21. d TLOAEL: 3 %NR1 99.9 LAB ENOrig3 %Orig%PUFormosan Subterranean TermitePOPABND LIT(Coptotermes formosanus)POP21. d TLOAEL: 2.99 %NR1 99.8 LAB ENOrig3 %Orig%PURef #166369Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Owojori OJ;Healey J;Princz J;Siciliano SDTitle:Can Avoidance Behavior of the Mite Oppia nitens be Used as a Rapid Toxicity Test for SoilsContaminated with Metals or Organic Chemicals?Year:2011Source:Environ. Toxicol. Chem. 30(11): 2594-2601Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.MiteBEHCHEM ART(Oppia nitens)AVO2. d TEC50: 2429.46 ppmNR1 99 LAB DA 6.0*Orig2454 mg/kgOrigmg/kgPUMonday, June 15, 2015Page 41 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166372Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Princz JI;Behan-Pelletier VM;Scroggins RP;Siciliano SDTitle:Oribatid Mites in Soil Toxicity Testing - The Use of Oppia nitens (C.L. Koch) as a New TestSpeciesYear:2010Source:Environ. Toxicol. Chem. 29(4): 971-979Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.MiteMORMORT NAT(Oppia nitens)MOR28. d TLC50: 250 ppmNR1 100 LAB DA 5.2Orig250 mg/kg dry wtOrigmg/kg dry wtADMiteMORMORT NAT(Oppia nitens)MOR28. d TLC50: 847 ppmNR1 100 LAB DA 4.4Orig847 mg/kg dry wtOrigmg/kg dry wtADMiteMORMORT NAT(Oppia nitens)MOR28. d TLC50: 530 ppmNR1 100 LAB DA 4.4Orig530 mg/kg dry wtOrigmg/kg dry wtADRef #166375Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Stegger P;Ebke KP;Rombke JTitle:Boric Acid as Alternative Reference Substance for Earthworm Field TestsYear:2011Source:J. Soils Sediments 11: 330-335Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.EarthwormPOPABND NAT(Lumbricus terrestris)POP28. d TLOAEL: 186.63 kg/haNR1 >=99.8 FIELDN DUOrig187 kg/haOrigkg/haPOEarthwormPOPABND NAT(Lumbricus terrestris)POP28. d TLOAEL: 186.63 kg/haNR1 >=99.8 FIELDN DUOrig187 kg/haOrigkg/haPOEarthwormPOPABND NAT(Lumbricus castaneus)POP28. d TLOAEL: 186.63 kg/haNR1 >=99.8 FIELDN DUOrig187 kg/haOrigkg/haPOEarthwormPOPABND NAT(Allolobophora chlorotica)POP28. d TLOAEL: 186.63 kg/haNR1 >=99.8 FIELDN DUOrig187 kg/haOrigkg/haPOEarthwormPOPABND NAT(Allolobophora chlorotica)POP28. d TNOAEL: 748.5 kg/haNR1 >=99.8 FIELDN DUOrig750 kg/haOrigkg/haPOMonday, June 15, 2015Page 42 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166375Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Stegger P;Ebke KP;Rombke JTitle:Boric Acid as Alternative Reference Substance for Earthworm Field TestsYear:2011Source:J. Soils Sediments 11: 330-335Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Oligochaete FamilyPOPABND NAT(NR Lumbricidae)POP28. d TLOAEL: 186.63 kg/haNR1 >=99.8 FIELDN DUOrig187 kg/haOrigkg/haJVPOOligochaete FamilyPOPABND NAT(NR Lumbricidae)POP28. d TLOAEL: 186.63 kg/haNR1 >=99.8 FIELDN DUOrig187 kg/haOrigkg/haPOOligochaete FamilyPOPABND NAT(NR Lumbricidae)POP28. d TLOAEL: 186.63 kg/haNR1 >=99.8 FIELDN DUOrig187 kg/haOrigkg/haJVPOWormPOPABND NAT(Aporrectodea caliginosa)POP28. d TLOAEL: 186.63 kg/haNR1 >=99.8 FIELDN DUOrig187 kg/haOrigkg/haPOWormPOPABND NAT(Aporrectodea rosea)POP28. d TNOAEL: 186.63 kg/haLOAEL: 748.5 kg/ha 1 >=99.8 FIELDN DUOrig187 kg/haOrig750 kg/haPORef #166381Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Capinera JLTitle:"Cuban Brown Snail, Zachrysia provisoria (Gastropoda): Damage Potential and Control"Year:2013Source:Crop Prot. 52(0): 57-63Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Cuba Garden ZachrysiaBEHFCNS NR(Zachrysia provisoria)FDB5. d TLOAEL: 0.0125 gNR1 5 LAB ENOrig0.25 gOriggGCuba Garden ZachrysiaBEHFCNS NR(Zachrysia provisoria)FDB4. d TLOAEL: 0.0125 gNR1 5 LAB ENOrig0.25 gOriggGCuba Garden ZachrysiaMORMORT NR(Zachrysia provisoria)MOR12. d TLOAEL: 0.0125 gNR1 5 LAB ENOrig0.25 gOriggGMonday, June 15, 2015Page 43 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166381Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Capinera JLTitle:"Cuban Brown Snail, Zachrysia provisoria (Gastropoda): Damage Potential and Control"Year:2013Source:Crop Prot. 52(0): 57-63Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Cuba Garden ZachrysiaMORMORT NR(Zachrysia provisoria)MOR5. d TNOAEL: 0.0125 gNR1 5 LAB ENOrig0.25 gOriggGRef #166387Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Singh DK;Abood F;Abdul-Hamid H;Ashaari Z;Abdu ATitle:Boric Acid Toxicity Trials on the Wood Borer Heterobostrychus aequalis Waterhouse(Coleoptera: Bostrychidae)Year:2011Source:Am. J. Agric. Biol. Sci. 6(1): 84-91Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Oriental Wood BorerBEHFDNG LIT(Heterobostrychus aequalis)FDB14. d TLOAEL: 1 %NR1 100 LAB ENOrig1 %Orig%ADOriental Wood BorerBEHFECL LIT(Heterobostrychus aequalis)FDB14. d TLOAEL: 1 %NR1 100 LAB ENOrig1 %Orig%ADOriental Wood BorerMORMORT LIT(Heterobostrychus aequalis)MOR14. d TLOAEL: 1 %NR1 100 LAB ENOrig1 %Orig%ADRef #166393Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Becker L;Scheffczyk A;Forster B;Oehlmann J;Princz J;Rombke J;Moser TTitle:"Effects of Boric Acid on Various Microbes, Plants, and Soil Invertebrates"Year:2011Source:J. Soils Sediments 11(2): 238-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Ground BeetleBEHFCNS NAT(Pterostichus cupreus)FDB4. d TEC50: 1335.29 mg/kg dNR1 >=99.5 LAB DA 5.7 to 5.8Orig1342 mg/kg d soilOrigmg/kg d soilAD>2 to <10wkPUMonday, June 15, 2015Page 44 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166393Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Becker L;Scheffczyk A;Forster B;Oehlmann J;Princz J;Rombke J;Moser TTitle:"Effects of Boric Acid on Various Microbes, Plants, and Soil Invertebrates"Year:2011Source:J. Soils Sediments 11(2): 238-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SpringtailBEHCHEM ART(Folsomia candida)AVO2. d TEC50: 1433.8 mg/kg dNR1 >=99.5 LAB DA 6.1 to 6.6Orig1441 mg/kg d soilOrigmg/kg d soil14 dPURef #166394Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Buyukguzel E;Buyukguzel K;Snela M;Erdem M;Radtke K;Ziemnicki K;Adamski ZTitle:"Effect of Boric Acid on Antioxidant Enzyme Activity, Lipid Peroxidation, and Ultrastructure ofMidgut and Fat Body of Galleria mellonella"Year:2013Source:Cell Biol. Toxicol. 29(2): 117-129Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Greater Wax MothBCMCTLS NON(Galleria mellonella)ENZd TLOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV7 insCRYGreater Wax MothBCMMLDH NON(Galleria mellonella)BCMd TLOAEL: 154.44 ppmNR1 99 LAB FDOrig156 ppmOrigppmLV7 insCRYGreater Wax MothMORMORT NON(Galleria mellonella)MORd TLC01: 1.33 ppmNR1 99 LAB FDOrig1.35 ppmOrigppmLV7 insCRYGreater Wax MothMORMORT NON(Galleria mellonella)MORd TLC05: 5.4 ppmNR1 99 LAB FDOrig5.46 ppmOrigppmLV7 insCRYGreater Wax MothMORMORT NON(Galleria mellonella)MORd TLC10: 11.4 ppmNR1 99 LAB FDOrig11.52 ppmOrigppmLV7 insCRYGreater Wax MothMORMORT NON(Galleria mellonella)MORd TLC30: 54.07 ppmNR1 99 LAB FDOrig54.62 ppmOrigppmLV7 insCRYGreater Wax MothMORMORT NON(Galleria mellonella)MORd TLC50: 158.4 ppmNR1 99 LAB FDOrig160 ppmOrigppmLV7 insCRYMonday, June 15, 2015Page 45 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166394Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Buyukguzel E;Buyukguzel K;Snela M;Erdem M;Radtke K;Ziemnicki K;Adamski ZTitle:"Effect of Boric Acid on Antioxidant Enzyme Activity, Lipid Peroxidation, and Ultrastructure ofMidgut and Fat Body of Galleria mellonella"Year:2013Source:Cell Biol. Toxicol. 29(2): 117-129Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Greater Wax MothMORMORT NON(Galleria mellonella)MORd TLC95: 4657.16 ppmNR1 99 LAB FDOrig4704.2 ppmOrigppmLV7 insCRYRef #166586Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Durmus Y;Buyukguzel KTitle:Biological and Immune Response of Galleria mellonella (Lepidoptera: Pyralidae) to SodiumTetraborateYear:2008Source:J. Econ. Entomol. 101(3): 777-783Test Chemical:Boron sodium oxide (B4Na2O7)CAS Number:1330434Lifestage:AgeFormul.Greater Wax MothBCMLYZM NON(Galleria mellonella)ENZ7. ins TLOAEL: 0.00495 %NR1 99 LAB FDOrig0.005 %Orig%LV1 insCRYGreater Wax MothMORSURV NON(Galleria mellonella)MOR7. ins TNOAEL: 0.099 %LOAEL: 0.198 %1 99 LAB FDOrig0.1 %Orig0 %LV1 insCRYRef #166607Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kose C;Terzi E;Kartal SNTitle:"Evaluation of Decay and Termite Resistance of Wood Treated with Copper in Combination withBoron and N'-N-(1,8-Naphthalyl) Hydroxylamine (NHA-Na)"Year:2009Source:Int. Biodeterior. Biodegrad. 63(6): 727-731Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Formosan Subterranean TermiteMORMORT NR(Coptotermes formosanus)MOR21. d TNR-LETH: 0.1 %NR1 100 LAB ENOrig0.1 %Orig%Formosan Subterranean TermitePOPABND NR(Coptotermes formosanus)POP21. d TLOAEL: 0.1 %NR1 100 LAB ENOrig0.1 %Orig%Monday, June 15, 2015Page 46 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166693Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kartal SN;Yoshimura T;Imamura YTitle:Modification of Wood with Si Compounds to Limit Boron Leaching from Treated Wood and toIncrease Termite and Decay ResistanceYear:2009Source:Int. Biodeterior. Biodegrad. 63(2): 187-190Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Formosan Subterranean TermitePOPABND NR(Coptotermes formosanus)POP21. d TLOAEL: 1 %NR1 100 LAB ENOrig1 %Orig%Monday, June 15, 2015Page 47 of 47Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Table 1 for Terrestrial Plant Studies (comparable species and endpoints)Boric Acid CaseCAS Number:1303964PC Code:Download Date:11/4/2014Terrestrial monocotsTaxa_Code:MTPAcuteRef #52326Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Mondal AB;Sarkar KK;Ghimiray TS;Sadhu DPTitle:Effect of Borax on Some Seedling Characters in Bread WheatYear:1997Source:Environ. Ecol. 15(3): 543-544Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Bread WheatGRONROT FLT(Triticum aestivum)GRO>=4. d TLOAEL: 125 ppmNR4 100 LAB SOOrig125 ppmOrigppmSDBread WheatGRONROT FLT(Triticum aestivum)GRO>=4. d TNOAEL: 125 ppmLOAEL: 250 ppm4 100 LAB SOOrig125 ppmOrig250 ppmSDBread WheatGRONROT FLT(Triticum aestivum)GRO>=4. d TNOAEL: 125 ppmLOAEL: 250 ppm4 100 LAB SOOrig125 ppmOrig250 ppmSDRef #54776Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Temesagdie P;Takano TTitle:"Effect of Treated Seeds with H2BO3, GA3, KNO3 and ZnSO4 on Seedling Growth of SweetCorn and Yard Long Bean"Year:1992Source:Kasetsart J. Nat. Sci. 26(5): 34-40Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.CornGROWGHT FLT(Zea mays)GRO10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDMonday, June 15, 2015Page 1 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #54776Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Temesagdie P;Takano TTitle:"Effect of Treated Seeds with H2BO3, GA3, KNO3 and ZnSO4 on Seedling Growth of SweetCorn and Yard Long Bean"Year:1992Source:Kasetsart J. Nat. Sci. 26(5): 34-40Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.CornGROWGHT FLT(Zea mays)GRO10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDCornGROWGHT FLT(Zea mays)GRO10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDRef #56070Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Adriano DC;Kaplan DI;Burkman WG;Mills GLTitle:Long-Term Phytoavailability of Soil-Applied Organo-BoratesYear:1988Source:J. Environ. Qual. 17(3): 485-492Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SudangrassGROBMAS NAT(Sorghum bicolor ssp. drummondii)GROhv TNOAEL: 12 ppmNR4 100 LAB ENOrig12 mg/kgOrigmg/kgSDSudangrassGROBMAS NAT(Sorghum bicolor ssp. drummondii)GROhv TNOAEL: 12 ppmNR2 100 LAB ENOrig12 mg/kgOrigmg/kgSDRef #57592Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Saric T;Saciragic BTitle:Effect of Oat Seed Treatment with MicroelementsYear:1969Source:Plant Soil 31(1): 185-187Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.OatGROHGHT NAT(Avena sp.)GRO<=1. gs TNOAEL: 0.02 %NR2 100 FIELDN SOOrig0.02 %Orig%SDMonday, June 15, 2015Page 2 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #59517Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kluge R;Podlesak WTitle:Plant Critical Levels for the Evaluation of Boron Toxicity in Spring Barley (Hordeum vulgare L.)Year:1985Source:Plant Soil 83: 381-388Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyPHYDAMG NAT(Hordeum vulgare)INJstg TNOAEL: 41 ppmNR1 100 LAB PR 5.2 to5.6Orig41 mg/kg dry wtOrigmg/kg dry wtSDBarleyPHYDAMG NAT(Hordeum vulgare)INJstg TNOAEL: 68 ppmNR1 100 LAB PR 5.2 to5.6Orig68 mg/kg dry wtOrigmg/kg dry wtSDBarleyPHYDAMG NAT(Hordeum vulgare)INJstg TNOAEL: 71 ppmNR1 100 LAB PR 5.2 to5.6Orig71 mg/kg dry wtOrigmg/kg dry wtSDBarleyPHYDAMG NAT(Hordeum vulgare)INJstg TNOAEL: 27 ppmNR1 100 LAB PR 5.2 to5.6Orig27 mg/kg dry wtOrigmg/kg dry wtSDBarleyPHYDAMG NAT(Hordeum vulgare)INJstg TNOAEL: 73 ppmNR1 100 LAB PR 5.2 to5.6Orig73 mg/kg dry wtOrigmg/kg dry wtSDBarleyPHYDAMG NAT(Hordeum vulgare)INJstg TNOAEL: 65 ppmNR1 100 LAB PR 5.2 to5.6Orig65 mg/kg dry wtOrigmg/kg dry wtSDBarleyPHYDAMG NAT(Hordeum vulgare)INJstg TNOAEL: 62 ppmNR1 100 LAB PR 5.2 to5.6Orig62 mg/kg dry wtOrigmg/kg dry wtSDRef #66651Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yau SK;Nachit M;Ryan JTitle:"Variation in Growth, Development, and Yield of Durum Wheat in Response to High Soil Boron.II. Differences Between Genotypes"Year:1997Source:Aust. J. Agric. Res. 48(7): 951-957Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatGROBMAS UKS(Triticum aestivum)GROhv TNOAEL: 7.1 ppmLOAEL: 17.4 ppm2 100 LAB DAOrig7.1 mg/kgOrig17 mg/kgMonday, June 15, 2015Page 3 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #66651Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yau SK;Nachit M;Ryan JTitle:"Variation in Growth, Development, and Yield of Durum Wheat in Response to High Soil Boron.II. Differences Between Genotypes"Year:1997Source:Aust. J. Agric. Res. 48(7): 951-957Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatGROBMAS UKS(Triticum aestivum)GROhv TNOAEL: 17.4 ppmNR2 100 LAB DAOrig17.4 mg/kgOrigmg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TLOAEL: 7.1 ppmNR2 100 LAB DAOrig7.1 mg/kgOrigmg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TLOAEL: 7.1 ppmNR2 100 LAB DAOrig7.1 mg/kgOrigmg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TLOAEL: 7.1 ppmNR2 100 LAB DAOrig7.1 mg/kgOrigmg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TNOAEL: 17.4 ppmNR2 100 LAB DAOrig17.4 mg/kgOrigmg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TNOAEL: 7.1 ppmLOAEL: 17.4 ppm2 100 LAB DAOrig7.1 mg/kgOrig17 mg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TNOAEL: 7.1 ppmLOAEL: 17.4 ppm2 100 LAB DAOrig7.1 mg/kgOrig17 mg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TNOAEL: 17.4 ppmNR2 100 LAB DAOrig17.4 mg/kgOrigmg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TNOAEL: 17.4 ppmNR2 100 LAB DAOrig17.4 mg/kgOrigmg/kgDurum WheatGROBMAS UKS(Triticum durum)GROhv TNOAEL: 17.4 ppmNR2 100 LAB DAOrig17.4 mg/kgOrigmg/kgMonday, June 15, 2015Page 4 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #67244Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Davis JG;Hossner LR;Persaud NTitle:Elemental Toxicity Effects on Germination and Growth of Pearl Millet SeedlingsYear:1993Source:J. Plant Nutr. 16(10): 1957-1968Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Pearl MilletGROLGTH FLT(Pennisetum glaucum)GRO7. d TNOAEL: 0.0075 MLOAEL: 0.01 M1 100 LAB DAOrig0.0075 MOrig0 MSDPearl MilletGROLGTH FLT(Pennisetum glaucum)GRO7. d TNOAEL: 0.005 MLOAEL: 0.0075 M1 100 LAB DAOrig0.005 MOrig0 MSDPearl MilletGROLGTH FLT(Pennisetum glaucum)GRO7. d TNOAEL: 0.0075 MLOAEL: 0.01 M1 100 LAB DAOrig0.0075 MOrig0 MSDRef #71184Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Karabal E;Yucel M;Oktem HATitle:Antioxidant Responses of Tolerant and Sensitive Barley Cultivars to Boron ToxicityYear:2003Source:Plant Sci. 164(6): 925-933Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROWGHT MIX(Hordeum vulgare)GRO5. d TLOAEL: 5 mMNR2 100 LAB DAOrig5 mMOrigmMSL8 dBarleyGROWGHT MIX(Hordeum vulgare)GRO5. d TNOAEL: 5 mMLOAEL: 10 mM2 100 LAB DAOrig5 mMOrig10 mMSL8 dRef #96218Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Simoglou KB;Dordas CTitle:"Effect of Foliar Applied Boron, Manganese and Zinc on Tan Spot in Winter Durum Wheat"Year:2006Source:Crop Prot. 25(7): 657-663Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 5 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #96218Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Simoglou KB;Dordas CTitle:"Effect of Foliar Applied Boron, Manganese and Zinc on Tan Spot in Winter Durum Wheat"Year:2006Source:Crop Prot. 25(7): 657-663Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Durum WheatGROHGHT NAT(Triticum durum)GRO45. stg TNOAEL: 6.25 ppmNR1 100 FIELDN FS 8.15Orig6.25 mg/LOrigmg/LRef #105883Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Anaka A;Wickstrom M;Siciliano SDTitle:"Increased Sensitivity and Variability of Phytotoxicity Responses in Arctic Soils to a ReferenceToxicant, Boric Acid"Year:2008Source:Environ. Toxicol. Chem. 27(3): 720-726Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Streambank WheatgrassGROLGTH NAT(Elymus lanceolatus)GRO21. d TIC20: 100-200 ppmNR7 100 LAB DA 4.4OrigOrigmg/kgSDStreambank WheatgrassGROLGTH NAT(Elymus lanceolatus)GRO21. d TIC20: 500-600 ppmNR7 100 LAB DA 4.4OrigOrigmg/kgSDStreambank WheatgrassGROLGTH NAT(Elymus lanceolatus)GRO21. d TIC20: 100-200 ppmNR7 100 LAB DA 4.4OrigOrigmg/kgSDStreambank WheatgrassGROLGTH NAT(Elymus lanceolatus)GRO21. d TIC20: <100 ppmNR7 100 LAB DA 4.4Orig<100 mg/kgOrigmg/kgSDStreambank WheatgrassGROLGTH NAT(Elymus lanceolatus)GRO21. d TIC20: <100 ppmNR7 100 LAB DA 4.4Orig<100 mg/kgOrigmg/kgSDStreambank WheatgrassGROLGTH NAT(Elymus lanceolatus)GRO21. d TIC20: 3200-3300 ppmNR7 100 LAB DA 4.4OrigOrigmg/kgSDMonday, June 15, 2015Page 6 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106676Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yau SK;Saxena MCTitle:"Variation in Growth, Development, and Yield of Durum Wheat in Response to High Soil Boron.I. Average Effects"Year:1997Source:Aust. J. Agric. Res. 48(7): 945-949Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Durum WheatGROBMAS ART(Triticum durum)GROhv TLOAEL: 7.1 ppmNR2 99.5 LAB DA 8.1Orig7.1 mg/kgOrigmg/kgSDDurum WheatPHYDAMG ART(Triticum durum)INJstg TLOAEL: 7.1 ppmNR2 99.5 LAB DA 8.1Orig7.1 mg/kgOrigmg/kgSDRef #108828Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rozema J;De Bruin J;Broekman RATitle:Effect of Boron on the Growth and Mineral Economy of Some Halophytes and Non-HalophytesYear:1992Source:New Phytol. 121(2): 249-256Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Tick QuackgrassGRORLGR HYP(Thinopyrum pycnanthum)GRO28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Ref #151386Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aydin M;Cakir FTitle:Research on Weed Species for Phytoremediation of Boron Polluted SoilYear:2009Source:Afr. J. Biotechnol. 8(18): 4514-4518Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Barnyard GrassGROLGTH NAT(Echinochloa crus-galli)GRO35. d TNOAEL: 30 ppmNR1 100 LAB DA 7.87*Orig30 mg/kg soilOrigmg/kg soilSDBermudagrassGROLGTH NAT(Cynodon dactylon)GRO35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHMonday, June 15, 2015Page 7 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #151386Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aydin M;Cakir FTitle:Research on Weed Species for Phytoremediation of Boron Polluted SoilYear:2009Source:Afr. J. Biotechnol. 8(18): 4514-4518Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Johnson GrassGROLGTH NAT(Sorghum halepense)GRO35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHPurple NutsedgeGROLGTH NAT(Cyperus rotundus)GRO35. d TLOAEL: 30 ppmNR1 100 LAB DA 7.87*Orig30 mg/kg soilOrigmg/kg soilRHRef #166365Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Esim N;Tiryaki D;Karadagoglu O;Atici OTitle:Toxic Effects of Boron on Growth and Antioxidant System Parameters of Maize (Zea mays L.)RootsYear:2013Source:Toxicol. Ind. Health 29(9): 800-805Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CornGROLGTH HYP(Zea mays)GRO2. d TLOAEL: 2 mMNR1 100 LAB HPOrig2 mMOrigmMSL9 dRef #166383Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:El-Feky SS;El-Shintinawy FA;Shaker EM;El-Din HASTitle:Effect of Elevated Boron Concentrations on the Growth and Yield of Barley (Hordeum vulgareL.) and Alleviation of Its Toxicity Using Different Plant Growth ModulatorsYear:2012Source:Aust. J. Crop Sci. 6(12): 1687-1695Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROHGHT NAT(Hordeum vulgare)GRO22. d TNOAEL: 1.5 ppmLOAEL: 3 ppm1 100 LAB DA 7.5*Orig1.5 mg/LOrig3 mg/LGPSMonday, June 15, 2015Page 8 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166383Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:El-Feky SS;El-Shintinawy FA;Shaker EM;El-Din HASTitle:Effect of Elevated Boron Concentrations on the Growth and Yield of Barley (Hordeum vulgareL.) and Alleviation of Its Toxicity Using Different Plant Growth ModulatorsYear:2012Source:Aust. J. Crop Sci. 6(12): 1687-1695Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROWGHT NAT(Hordeum vulgare)GRO22. d TNOAEL: 1.5 ppmLOAEL: 3 ppm1 100 LAB DA 7.5*Orig1.5 mg/LOrig3 mg/LGPSRef #166389Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Turan MA;Taban N;Taban STitle:Effect of Calcium on the Alleviation of Boron Toxicity and Localization of Boron and Calcium inCell Wall of WheatYear:2009Source:Notulae Bot. Horti Agrobot. Cluj-Napoca 37(2): 99-103Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatGROBMAS NAT(Triticum aestivum)GRO60. d TNOAEL: 5 ppmLOAEL: 10 ppm1 100 LAB DA 8.08*Orig5 mg/kgOrig10 mg/kgSDRef #166393Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Becker L;Scheffczyk A;Forster B;Oehlmann J;Princz J;Rombke J;Moser TTitle:"Effects of Boric Acid on Various Microbes, Plants, and Soil Invertebrates"Year:2011Source:J. Soils Sediments 11(2): 238-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Common OatGROBMAS NAT(Avena sativa)GRO14. d TEC50: 181.09 mg/kg dNR1 >=99.5 LAB DA 6.4*Orig182 mg/kg d soilOrigmg/kg d soilSDPUCommon OatGROLGTH NAT(Avena sativa)GRO14. d TEC50: 306.46 mg/kg dNR1 >=99.5 LAB DA 6.4*Orig308 mg/kg d soilOrigmg/kg d soilSDPUMonday, June 15, 2015Page 9 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166401Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hosseini SM;Maftoun M;Karimian N;Ronaghi A;Emam YTitle:Effect of Zinc x Boron Interaction on Plant Growth and Tissue Nutrient Concentration of CornYear:2007Source:J. Plant Nutr. 30: 773-781Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CornGROHGHT NAT(Zea mays)GRO70. d TNOAEL: 10 ppmLOAEL: 20 ppm1 100 LAB DA 7.5*Orig10 ug/gOrig20 ug/gSDPORef #166668Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ochiai K;Uemura S;Shimizu A;Okumoto Y;Matoh TTitle:Boron Toxicity in Rice (Oryza sativa L.). I. Quantitative Trait Locus (QTL) Analysis of Toleranceto Boron ToxicityYear:2008Source:Theor. Appl. Genet. 117(1): 125-133Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.RiceGROHGHT NAT(Oryza sativa)GRO155. d TNOAEL: 10 ppmLOAEL: 30 ppm1 100 LAB WAOrig10 g/m3Orig30 g/m3SL18 dRiceGROHGHT NAT(Oryza sativa)GRO130. d TNOAEL: 10 ppmLOAEL: 30 ppm1 100 LAB WAOrig10 g/m3Orig30 g/m3SL18 dRiceGROHGHT NAT(Oryza sativa)GRO130. d TNOAEL: 10 ppmLOAEL: 30 ppm1 100 LAB WAOrig10 g/m3Orig30 g/m3SL18 dRiceGROWGHT CUL(Oryza sativa)GRO7. d TNOAEL: 54 ppmNR1 100 LAB HPOrig54 g/m3Origg/m3SDRicePHYDAMG CUL(Oryza sativa)INJ7. d TLOAEL: 27 ppmNR1 100 LAB HPOrig27 g/m3Origg/m3SDRicePHYDAMG CUL(Oryza sativa)INJ7. d TLOAEL: 27 ppmNR1 100 LAB HPOrig27 g/m3Origg/m3SDRicePHYDAMG CUL(Oryza sativa)INJ7. d TNOAEL: 11 ppmNR1 100 LAB HPOrig11 g/m3Origg/m3SDMonday, June 15, 2015Page 10 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166668Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ochiai K;Uemura S;Shimizu A;Okumoto Y;Matoh TTitle:Boron Toxicity in Rice (Oryza sativa L.). I. Quantitative Trait Locus (QTL) Analysis of Toleranceto Boron ToxicityYear:2008Source:Theor. Appl. Genet. 117(1): 125-133Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.RicePHYDAMG CUL(Oryza sativa)INJ7. d TNOAEL: 11 ppmNR1 100 LAB HPOrig11 g/m3Origg/m3SDRef #166713Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kalayci M;Alkan A;Cakmak I;Bayramoglu O;Yilmaz A;Aydin M;Ozbek V;Ekiz H;Ozberisoy FTitle:Studies on Differential Responses ofWheat Cultivars to Boron ToxicityYear:1998Source:Euphytica 100(1-3): 123-129Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.WheatPHYDAMG NAT(Triticum sp.)INJhv TLOAEL: 89.2 lb/acreNR1 100 FIELDN GGOrig100 kg/haOrigkg/haSDWheatPHYDAMG NAT(Triticum sp.)INJhv TNOAEL: 89.2 lb/acreNR1 100 FIELDN GGOrig100 kg/haOrigkg/haSDRef #166736Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Nable ROTitle:Resistance to Boron Toxicity Amongst Several Barley and Wheat Cultivars: A PreliminaryExamination of the Resistance MechanismYear:1988Source:Plant Soil 112(1): 45-52Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROBMAS HYP(Hordeum vulgare)GRO35. d TNOAEL: 500 uMLOAEL: 1000 uM1 100 LAB HP 5.5* to6.0*Orig500 uMOrig1000 uM4 dppMonday, June 15, 2015Page 11 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166736Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Nable ROTitle:Resistance to Boron Toxicity Amongst Several Barley and Wheat Cultivars: A PreliminaryExamination of the Resistance MechanismYear:1988Source:Plant Soil 112(1): 45-52Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROBMAS HYP(Hordeum vulgare)GRO35. d TNOAEL: 200 uMLOAEL: 500 uM1 100 LAB HP 5.5* to6.0*Orig200 uMOrig500 uM4 dppBarleyGROBMAS HYP(Hordeum vulgare)GRO35. d TNOAEL: 500 uMLOAEL: 1000 uM1 100 LAB HP 5.5* to6.0*Orig500 uMOrig1000 uM4 dppBarleyGROBMAS HYP(Hordeum vulgare)GRO35. d TNOAEL: 2000 uMLOAEL: 5000 uM1 100 LAB HP 5.5* to6.0*Orig2000 uMOrig5000 uM4 dppBarleyGROBMAS HYP(Hordeum vulgare)GRO35. d TNOAEL: 2000 uMLOAEL: 5000 uM1 100 LAB HP 5.5* to6.0*Orig2000 uMOrig5000 uM4 dppBread WheatGROBMAS HYP(Triticum aestivum)GRO35. d TNOAEL: 500 uMLOAEL: 1000 uM1 100 LAB HP 5.5* to6.0*Orig500 uMOrig1000 uM4 dppBread WheatGROBMAS HYP(Triticum aestivum)GRO35. d TNOAEL: 200 uMLOAEL: 500 uM1 100 LAB HP 5.5* to6.0*Orig200 uMOrig500 uM4 dppBread WheatGROBMAS HYP(Triticum aestivum)GRO35. d TNOAEL: 200 uMLOAEL: 500 uM1 100 LAB HP 5.5* to6.0*Orig200 uMOrig500 uM4 dppBread WheatGROBMAS HYP(Triticum aestivum)GRO35. d TNOAEL: 200 uMLOAEL: 500 uM1 100 LAB HP 5.5* to6.0*Orig200 uMOrig500 uM4 dppBread WheatGROBMAS HYP(Triticum aestivum)GRO35. d TNOAEL: 500 uMLOAEL: 1000 uM1 100 LAB HP 5.5* to6.0*Orig500 uMOrig1000 uM4 dppBread WheatGROBMAS HYP(Triticum aestivum)GRO35. d TNOAEL: 2000 uMLOAEL: 5000 uM1 100 LAB HP 5.5* to6.0*Orig2000 uMOrig5000 uM4 dppMonday, June 15, 2015Page 12 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166743Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Riley MM;Robson AD;Dellar GA;Gartrell JWTitle:Critical Toxic Concentrations of Boron are Variable in BarleyYear:1994Source:J. Plant Nutr. 17(10): 1701-1719Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyPHYGINJ NAT(Hordeum vulgare)INJma TNOAEL: 1 ppmLOAEL: 2 ppm1 100 LAB DA 5.6*Orig1 ug/g soilOrig2 ug/g soilSDRef #166754Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hossain AKMZ;Asgar MDA;HossainMA;Tosaki T;Koyama H;Hara TTitle:Boron-Calcium Synergically Alleviates Aluminum Toxicity in Wheat Plants (Triticum aestivum L.)Year:2005Source:Soil Sci. Plant Nutr. 51(1): 43-49Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatGROLGTH HYP(Triticum aestivum)GRO8. d TNOAEL: 40 uMNR1 100 LAB HP 4.5Orig40 uMOriguMSL7 dRef #166760Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Nable ROTitle:Distribution of Boron Within Barley Genotypes with Differing Susceptibilities to Boron ToxicityYear:1991Source:J. Plant Nutr. 14(5): 453-462Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROWGHT CUL(Hordeum vulgare)GRO14. d TNOAEL: 2000 uMNR1 100 LAB CM 5.5 to6.0Orig2000 uMOriguMSL21 dppBarleyGROWGHT CUL(Hordeum vulgare)GRO14. d TNOAEL: 2000 uMNR1 100 LAB CM 5.5 to6.0Orig2000 uMOriguMSL21 dppBarleyGROWGHT CUL(Hordeum vulgare)GRO14. d TNOAEL: 2000 uMNR1 100 LAB CM 5.5 to6.0Orig2000 uMOriguMSL21 dppMonday, June 15, 2015Page 13 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166760Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Nable ROTitle:Distribution of Boron Within Barley Genotypes with Differing Susceptibilities to Boron ToxicityYear:1991Source:J. Plant Nutr. 14(5): 453-462Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROWGHT CUL(Hordeum vulgare)GRO14. d TNOAEL: 2000 uMNR1 100 LAB CM 5.5 to6.0Orig2000 uMOriguMSL21 dppRef #166779Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Inal A;Pilbeam DJ;Gunes ATitle:Silicon Increases Tolerance to Boron Toxicity and Reduces Oxidative Damage in BarleyYear:2009Source:J. Plant Nutr. 32(1): 112-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROWGHT NAT(Hordeum vulgare)GRO73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDRef #166783Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rehman S;Park TI;Kim YJ;Seo YW;Yun SJTitle:Inverse Relationship Between Boron Toxicity Tolerance and Boron Contents of Barley Seedand RootYear:2006Source:J. Plant Nutr. 29(10): 1779-1789Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 ppmOrigppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 ppmOrigppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 ppmOrigppmMonday, June 15, 2015Page 14 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166783Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rehman S;Park TI;Kim YJ;Seo YW;Yun SJTitle:Inverse Relationship Between Boron Toxicity Tolerance and Boron Contents of Barley Seedand RootYear:2006Source:J. Plant Nutr. 29(10): 1779-1789Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 ppmOrigppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 ppmOrigppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 ppmOrigppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 ppmOrigppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 ppmOrigppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmMonday, June 15, 2015Page 15 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166783Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rehman S;Park TI;Kim YJ;Seo YW;Yun SJTitle:Inverse Relationship Between Boron Toxicity Tolerance and Boron Contents of Barley Seedand RootYear:2006Source:J. Plant Nutr. 29(10): 1779-1789Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmBarleyGROWGHT FLT(Hordeum vulgare)GRO10. d TNOAEL: 10 ppmLOAEL: 100 ppm1 100 LAB DAOrig10 ppmOrig100 ppmTerrestrial dicotsTaxa_Code:DTPMonday, June 15, 2015Page 16 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.AcuteRef #54418Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Speir TW;August JA;Feltham CWTitle:"Assessment of the Feasibility of Using CCA (Copper, Chromium and Arsenic) - Treated andBoric Acid - Treated Sawdust as Soil Amendments I. Plant Growth and Element Uptake"Year:1992Source:Plant Soil 142(2): 235-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Dutch CloverGROBMAS ART(Trifolium repens)GRO119. d TLOAEL: 36 ppmNR1 100 LAB EN 7Orig36 mg/kgOrigmg/kgSDDutch CloverGROBMAS ART(Trifolium repens)GRO119. d TLOAEL: 36 ppmNR1 100 LAB EN 5Orig36 mg/kgOrigmg/kgSDLettuceGROBMAS ART(Lactuca sativa)GRO119. d TLOAEL: 36 ppmNR1 100 LAB EN 7Orig36 mg/kgOrigmg/kgSDLettuceGROBMAS ART(Lactuca sativa)GRO119. d TNOAEL: 36 ppmNR1 100 LAB EN 5Orig36 mg/kgOrigmg/kgSDSugar BeetGROBMAS ART(Beta vulgaris)GRO77. d TLOAEL: 36 ppmNR1 100 LAB EN 7Orig36 mg/kgOrigmg/kgSDSugar BeetGROBMAS ART(Beta vulgaris)GRO77. d TLOAEL: 36 ppmNR1 100 LAB EN 5Orig36 mg/kgOrigmg/kgSDRef #54776Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Temesagdie P;Takano TTitle:"Effect of Treated Seeds with H2BO3, GA3, KNO3 and ZnSO4 on Seedling Growth of SweetCorn and Yard Long Bean"Year:1992Source:Kasetsart J. Nat. Sci. 26(5): 34-40Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.Monday, June 15, 2015Page 17 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #54776Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Temesagdie P;Takano TTitle:"Effect of Treated Seeds with H2BO3, GA3, KNO3 and ZnSO4 on Seedling Growth of SweetCorn and Yard Long Bean"Year:1992Source:Kasetsart J. Nat. Sci. 26(5): 34-40Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.Yardlong BeanGROWGHT FLT(Vigna unguiculata ssp.sesquipedalis)GRO10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDYardlong BeanGROWGHT FLT(Vigna unguiculata ssp.sesquipedalis)GRO10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDYardlong BeanGROWGHT FLT(Vigna unguiculata ssp.sesquipedalis)GRO10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDRef #62604Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Marcar NE;Guo J;Crawford DFTitle:"Response of Eucalyptus camaldulensis Dehnh., E. globulus Labill. ssp. globulus and E.grandis W.Hill to Excess Boron and Sodium Chloride"Year:1999Source:Plant Soil 208(2): 251-257Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bluegum EucalyptusGROWGHT NAT(Eucalyptus globulus)GRO36. d TNOAEL: 0.46 mol/m3LOAEL: 0.93 mol/m3 1 100 LAB DAOrig0.46 mol/m3Orig1 mol/m3SL9 wkGrand Eucalyptus GRO WGHT NAT(Eucalyptus grandis)GRO 36. d TNOAEL: 0.46 mol/m3LOAEL: 0.93 mol/m3 1 100 LAB DAOrig0.46 mol/m3Orig1 mol/m3SL9 wkRed River Gum GRO WGHT NAT(Eucalyptus camaldulensis)GRO 36. d TNOAEL: 0.46 mol/m3LOAEL: 0.93 mol/m3 1 100 LAB DAOrig0.46 mol/m3Orig1 mol/m3SL9 wkMonday, June 15, 2015Page 18 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #82075Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ruiz JM;Rivero RM;Romero LTitle:Preliminary Studies on the Involvement of Biosynthesis of Cysteine and GlutathioneConcentration in the Resistance to B Toxicity in Sunflower PlantsYear:2003Source:Plant Sci. 165(4): 811-817Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Common Annual SunflowerGROWGHT UKS(Helianthus annuus)GRO15. d TLOAEL: 500 uMNR1 100 LAB DA 5.8Orig500 uMOriguM1 moRef #83668Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gunes A;Alpaslan M;Cikili Y;Ozcan HTitle:Effect of Zinc on the Alleviation of Boron Toxicity in TomatoYear:1999Source:J. Plant Nutr. 22(7): 1061-1068Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.TomatoGROWGHT NAT(Solanum lycopersicumlycopersicum)GRO35. d TLOAEL: 5 ppmNR3 100 FIELDA ENOrig5 mg/kg soilOrigmg/kg soilSL3 wkRef #106674Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rajput CBS;Singh BP;Mishra HPTitle:Effects of Foliar Application of Boron on MangoYear:1976Source:Sci. Hortic. 5(4): 311-313Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.MangoGROBMAS NAT(Mangifera indica)GRO91.32 d TNOAEL: 0.8 %NR4 100 FIELDN SPOrig0.8 %Orig%MangoGRONLEF NAT(Mangifera indica)GRO91.32 d TLOAEL: 0.2 %NR4 100 FIELDN SPOrig0.2 %Orig%Monday, June 15, 2015Page 19 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106675Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Mason GF;Guttridge CGTitle:"The Role of Calcium, Boron and Some Divalent Ions in Leaf Tipburn of Strawberry"Year:1974Source:Sci. Hortic. 2(3): 299-308Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Hybrid StrawberryPHYDAMG NAT(Fragaria x ananassa)INJ~6. d TNOAEL: 1000 ppmNR4 100 FIELDA DWOrig1000 ppmOrigppmHybrid StrawberryPHYDAMG NAT(Fragaria x ananassa)INJ~121.76 d TNOAEL: 0.01 ppmLOAEL: 0.1 ppm6 100 FIELDA DWOrig0.01 ppmOrig0 ppmRef #107383Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ghanati F;Morita A;Yokota HTitle:Deposition of Suberin in Roots of Soybean Induced by Excess BoronYear:2005Source:Plant Sci. 168(2): 397-405Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SoybeanGROLGTH AQU(Glycine max)GRO6. d TLOAEL: 5 mMNR1 100 LAB HPOrig5 mMOrigmMRef #108828Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rozema J;De Bruin J;Broekman RATitle:Effect of Boron on the Growth and Mineral Economy of Some Halophytes and Non-HalophytesYear:1992Source:New Phytol. 121(2): 249-256Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BeanGRORLGR HYP(Phaseolus vulgaris)GRO28. d TNOAEL: 0.35 mol/m3LOAEL: 1.75 mol/m3 1 100 LAB HP 6.5Orig0.35 mol/m3Orig2 mol/m3Common Foxglove GRO RLGR HYP(Digitalis purpurea)GRO 28. d TNOAEL: 0.35 mol/m3LOAEL: 1.75 mol/m3 1 100 LAB HP 6.5Orig0.35 mol/m3Orig2 mol/m3Monday, June 15, 2015Page 20 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #108828Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rozema J;De Bruin J;Broekman RATitle:Effect of Boron on the Growth and Mineral Economy of Some Halophytes and Non-HalophytesYear:1992Source:New Phytol. 121(2): 249-256Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.False MayweedGRORLGR HYP(Tripleurospermum maritima)GRO28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Goose TongueGRORLGR HYP(Plantago maritima)GRO28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Grassleaf OracheGRORLGR HYP(Atriplex littoralis)GRO28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Media SandspurryGRORLGR HYP(Spergularia maritima)GRO28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Thrift SeapinkGRORLGR HYP(Armeria maritima)GRO28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Woodland FigwortGRORLGR HYP(Scrophularia nodosa)GRO28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Woodland RagwortGRORLGR HYP(Senecio sylvaticus)GRO28. d TNOAEL: 0.35 mol/m3LOAEL: 1.75 mol/m3 1 100 LAB HP 6.5Orig0.35 mol/m3Orig2 mol/m3Ref #115189Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gunes A;Soylemezoglu G;Inal A;Bagci EG;Coban S;Sahin OTitle:Antioxidant and Stomatal Responses of Grapevine (Vitis vinifera L.) to Boron ToxicityYear:2006Source:Sci. Hortic. 110(3): 279-284Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.GrapeGROBMAS NAT(Vitis sp.)GRO73. d TNOAEL: 20 ppmLOAEL: 30 ppm1 100 LAB DA 7.91*Orig20 mg/kgOrig30 mg/kgMonday, June 15, 2015Page 21 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #115279Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yu CL;Luo SG;Peng XL;Liu YYTitle:"Effects of Boron, Zinc, and Iron on the Gentiopicroside Content and Yield of Gentian"Year:2006Source:Pedosphere 16(2): 210-214Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.GentianGROWGHT NAT(Gentiana manshurica)GROhv TNOAEL: 4.5 gNR1 100 FIELDN SP 8.2*Orig4.5 gOrigg2 yrRef #119264Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ardic M;Sekmen AH;Tokur S;Ozdemir F;Turkan ITitle:Antioxidant Responses of Chickpea Plants Subjected to Boron ToxicityYear:2009Source:Plant Biol. 11(3): 328-338Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Chick PeaGROLGTH HYP(Cicer arietinum)GRO7. d TNOAEL: 6.4 mMNR1 100 LAB HPOrig6.4 mMOrigmMSL21 dChick PeaGROLGTH HYP(Cicer arietinum)GRO7. d TNOAEL: 1.6 mMLOAEL: 6.4 mM1 100 LAB HPOrig1.6 mMOrig6 mMSL21 dRef #151386Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aydin M;Cakir FTitle:Research on Weed Species for Phytoremediation of Boron Polluted SoilYear:2009Source:Afr. J. Biotechnol. 8(18): 4514-4518Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Green AmaranthGROLGTH NAT(Amaranthus retroflexus)GRO35. d TNOAEL: 30 ppmNR1 100 LAB DA 7.87*Orig30 mg/kg soilOrigmg/kg soilSDLamb's-QuartersGROLGTH NAT(Chenopodium album)GRO35. d TNOAEL: 20 ppmLOAEL: 30 ppm1 100 LAB DA 7.87*Orig20 mg/kg soilOrig30 mg/kg soilSDMonday, June 15, 2015Page 22 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #151401Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cervilla LM;Blasco B;Rios JJ;Romero L;Ruiz JMTitle:Oxidative Stress and Antioxidants in Tomato (Solanum lycopersicum) Plants Subjected toBoron ToxicityYear:2007Source:Ann. Bot. 100(4): 747-756Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Garden TomatoGROBMAS ART(Solanum lycopersicum)GRO14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppGarden TomatoGROBMAS ART(Solanum lycopersicum)GRO14. d TNOAEL: 0.5 mMLOAEL: 2 mM1 100 LAB WA 5.8*Orig0.5 mMOrig2 mM42 dppRef #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.AlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: 9.5 ppmNR1 100 LAB ENOrig9.5 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: 70 ppmNR1 100 LAB ENOrig70 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: 81 ppmNR1 100 LAB ENOrig81 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDMonday, June 15, 2015Page 23 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.AlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: 67 ppmNR1 100 LAB ENOrig67 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: 119 ppmNR1 100 LAB ENOrig119 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC10: 149 ppmNR1 100 LAB ENOrig149 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: 184 ppmNR1 100 LAB ENOrig184 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: 309 ppmNR1 100 LAB ENOrig309 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: 370 ppmNR1 100 LAB ENOrig370 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: 216 ppmNR1 100 LAB ENOrig216 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: 284 ppmNR1 100 LAB ENOrig284 mg/LOrigmg/LSDMonday, June 15, 2015Page 24 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.AlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC25: 281 ppmNR1 100 LAB ENOrig281 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDMonday, June 15, 2015Page 25 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.AlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 160 ppmLOAEL: 320 ppm1 100 LAB ENOrig160 mg/LOrig320 mg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 160 ppmLOAEL: 320 ppm1 100 LAB ENOrig160 mg/LOrig320 mg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 160 ppmLOAEL: 320 ppm1 100 LAB ENOrig160 mg/LOrig320 mg/LSDAlfalfaGROLGTH FLT(Medicago sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 2.8 ppmNR1 100 LAB ENOrig2.8 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 92 ppmNR1 100 LAB ENOrig92 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 101 ppmNR1 100 LAB ENOrig101 mg/LOrigmg/LSDMonday, June 15, 2015Page 26 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.LettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 4.5 ppmNR1 100 LAB ENOrig4.5 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 3.7 ppmNR1 100 LAB ENOrig3.7 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 3.9 ppmNR1 100 LAB ENOrig3.9 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 5.3 ppmNR1 100 LAB ENOrig5.3 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 86 ppmNR1 100 LAB ENOrig86 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC10: 6 ppmNR1 100 LAB ENOrig6 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 89 ppmNR1 100 LAB ENOrig89 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 272 ppmNR1 100 LAB ENOrig272 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 27 ppmNR1 100 LAB ENOrig27 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 14 ppmNR1 100 LAB ENOrig14 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 255 ppmNR1 100 LAB ENOrig255 mg/LOrigmg/LSDMonday, June 15, 2015Page 27 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.LettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 213 ppmNR1 100 LAB ENOrig213 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 44 ppmNR1 100 LAB ENOrig44 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 30 ppmNR1 100 LAB ENOrig30 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC25: 63 ppmNR1 100 LAB ENOrig63 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: 180 ppmNR1 100 LAB ENOrig180 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDMonday, June 15, 2015Page 28 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.LettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDLettuceGROLGTH FLT(Lactuca sativa)GRO5. d TNOAEL: 320 ppmLOAEL: 640 ppm1 100 LAB ENOrig320 mg/LOrig640 mg/LSDMonday, June 15, 2015Page 29 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Wild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.5 ppmNR1 100 LAB ENOrig2.5 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.6 ppmNR1 100 LAB ENOrig2.6 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.4 ppmNR1 100 LAB ENOrig2.4 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.5 ppmNR1 100 LAB ENOrig2.5 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.3 ppmNR1 100 LAB ENOrig2.3 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.2 ppmNR1 100 LAB ENOrig2.2 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.1 ppmNR1 100 LAB ENOrig2.1 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.4 ppmNR1 100 LAB ENOrig2.4 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC10: 2.4 ppmNR1 100 LAB ENOrig2.4 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 9.5 ppmNR1 100 LAB ENOrig9.5 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 6.2 ppmNR1 100 LAB ENOrig6.2 mg/LOrigmg/LSDMonday, June 15, 2015Page 30 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Wild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 10 ppmNR1 100 LAB ENOrig10 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 11 ppmNR1 100 LAB ENOrig11 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 8 ppmNR1 100 LAB ENOrig8 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 8.7 ppmNR1 100 LAB ENOrig8.7 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 8.7 ppmNR1 100 LAB ENOrig8.7 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 8.6 ppmNR1 100 LAB ENOrig8.6 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC25: 7.4 ppmNR1 100 LAB ENOrig7.4 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 106 ppmNR1 100 LAB ENOrig106 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 38 ppmNR1 100 LAB ENOrig38 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 76 ppmNR1 100 LAB ENOrig76 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 75 ppmNR1 100 LAB ENOrig75 mg/LOrigmg/LSDMonday, June 15, 2015Page 31 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Wild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 55 ppmNR1 100 LAB ENOrig55 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 76 ppmNR1 100 LAB ENOrig76 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 64 ppmNR1 100 LAB ENOrig64 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 112 ppmNR1 100 LAB ENOrig112 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TEC50: 90 ppmNR1 100 LAB ENOrig90 mg/LOrigmg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 160 ppmLOAEL: 320 ppm1 100 LAB ENOrig160 mg/LOrig320 mg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 80 ppmLOAEL: 160 ppm1 100 LAB ENOrig80 mg/LOrig160 mg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 80 ppmLOAEL: 160 ppm1 100 LAB ENOrig80 mg/LOrig160 mg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 80 ppmLOAEL: 160 ppm1 100 LAB ENOrig80 mg/LOrig160 mg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 160 ppmLOAEL: 320 ppm1 100 LAB ENOrig160 mg/LOrig320 mg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 80 ppmLOAEL: 160 ppm1 100 LAB ENOrig80 mg/LOrig160 mg/LSDMonday, June 15, 2015Page 32 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Wild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 80 ppmLOAEL: 160 ppm1 100 LAB ENOrig80 mg/LOrig160 mg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 80 ppmLOAEL: 160 ppm1 100 LAB ENOrig80 mg/LOrig160 mg/LSDWild CarrotGROLGTH FLT(Daucus carota)GRO7. d TNOAEL: 160 ppmLOAEL: 320 ppm1 100 LAB ENOrig160 mg/LOrig320 mg/LSDRef #166349Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aquea F;Federici F;MoscosoC;Vega A;Jullian P;Haseloff J;Arce-Johnson PTitle:A Molecular Framework for the Inhibition of Arabidopsis Root Growth in Response to BoronToxicityYear:2012Source:Plant Cell Environ. 35(4): 719-734Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.RockcressGROLGTH HYP(Arabidopsis sp.)GRO5. d TLOAEL: 3 mMNR1 100 LAB HP 5.7*Orig3 mMOrigmMSL5 dRockcressGROLGTH HYP(Arabidopsis sp.)GRO0.5 d TNOAEL: 5 mMNR1 100 LAB HP 5.7*Orig5 mMOrigmMSL5 dRockcressGROLGTH HYP(Arabidopsis sp.)GRO1. d TNOAEL: 5 mMNR1 100 LAB HP 5.7*Orig5 mMOrigmMSL5 dMonday, June 15, 2015Page 33 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166350Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ardic M;Sekmen AH;Turkan I;Tokur S;Ozdemir FTitle:The Effects of Boron Toxicity on Root Antioxidant Systems of Two Chickpea (Cicer arietinumL.) CultivarsYear:2009Source:Plant Soil 314: 99-108Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Chick PeaGROLGTH HYP(Cicer arietinum)GRO7. d TLOAEL: 1.6 mMNR1 100 LAB HPOrig1.6 mMOrigmMSL21 dppChick PeaGROLGTH HYP(Cicer arietinum)GRO7. d TNOAEL: 6.4 mMNR1 100 LAB HPOrig6.4 mMOrigmMSL21 dppRef #166363Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rodriguez-Hernandez MC;Moreno DA;Carvajal M;Martinez-Ballesta MCTitle:Interactive Effects of Boron and NaCl Stress on Water and Nutrient Transport in Two BroccoliCultivarsYear:2013Source:Funct. Plant Biol. 40(7): 739-748Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BroccoliGROWGHT HYP(Brassica oleracea ssp. italica)GRO15. d TNOAEL: 4.3 ppmNR1 100 LAB HPOrig4.3 mg/LOrigmg/LSL21 dBroccoliGROWGHT HYP(Brassica oleracea ssp. italica)GRO15. d TNOAEL: 1.8 ppmLOAEL: 4.3 ppm1 100 LAB HPOrig1.8 mg/LOrig4 mg/LSL21 dRef #166377Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Van der Vliet L;Velicogna J;Princz J;Scroggins RTitle:Phytotoxkit: A Critical Look at a Rapid Assessment ToolYear:2012Source:Environ. Toxicol. Chem. 31(2): 316-323Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 34 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166377Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Van der Vliet L;Velicogna J;Princz J;Scroggins RTitle:Phytotoxkit: A Critical Look at a Rapid Assessment ToolYear:2012Source:Environ. Toxicol. Chem. 31(2): 316-323Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Red CloverGROLGTH ART(Trifolium pratense)GRO7. d TIC50: 500-1000 mg/kgNR1 100 LAB DA 7.5*OrigOrigmg/kg d soilSDRed CloverGROLGTH ART(Trifolium pratense)GRO3. d TIC50: 1000-1500 mg/kgNR1 100 LAB DA 7.5*OrigOrigmg/kg d soilSDRed CloverGROLGTH ART(Trifolium pratense)GRO5. d TIC50: 500-1000 mg/kgNR1 100 LAB DA 7.5*OrigOrigmg/kg d soilSDRed CloverGROLGTH ART(Trifolium pratense)GRO14. d TIC50: 500-1000 mg/kgNR1 100 LAB DA 7.5*OrigOrigmg/kg d soilSDRef #166379Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Will S;Eichert T;Fernandez V;Mohring J;Muller T;Romheld VTitle:Absorption and Mobility of Foliar-Applied Boron in Soybean as Affected by Plant Boron Statusand Application as a Polyol ComplexYear:2011Source:Plant Soil 344(1/2): 283-293Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SoybeanGROBMAS HYP(Glycine max)GRO21. d TNOAEL: 100 uMNR1 99.8 LAB MT 5.5*Orig100 uMOriguMSLPURef #166393Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Becker L;Scheffczyk A;Forster B;Oehlmann J;Princz J;Rombke J;Moser TTitle:"Effects of Boric Acid on Various Microbes, Plants, and Soil Invertebrates"Year:2011Source:J. Soils Sediments 11(2): 238-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 35 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166393Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Becker L;Scheffczyk A;Forster B;Oehlmann J;Princz J;Rombke J;Moser TTitle:"Effects of Boric Acid on Various Microbes, Plants, and Soil Invertebrates"Year:2011Source:J. Soils Sediments 11(2): 238-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.RapeseedGROBMAS NAT(Brassica napus)GRO14. d TEC50: 174.12 mg/kg dNR1 >=99.5 LAB DA 6.4*Orig175 mg/kg d soilOrigmg/kg d soilSDPURapeseedGROLGTH NAT(Brassica napus)GRO14. d TEC50: 355.22 mg/kg dNR1 >=99.5 LAB DA 6.4*Orig357 mg/kg d soilOrigmg/kg d soilSDPURef #166422Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rajak U;Rani R;Kumar R;Mandal BK;Prasad KKTitle:"Effect of Foliar Application of Urea, Borax and Zinc on Flowering, Fruiting and Fruit Quality ofAmrapali Mango"Year:2010Source:Environ. Ecol. 28(3): 1668-1671Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.MangoGROBMAS NAT(Mangifera sp.)GRO<=1. gs TNOAEL: 1 %NR1 100 FIELDN FSOrig1 %Orig%10 yrRef #166604Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cervilla LM;Rosales MA;Rubio-Wilhelmi MM;Sanchez-Rodriguez E;Blasco B;Rios JJ;RomeroL;Ruiz JMTitle:Involvement of Lignification and Membrane Permeability in the Tomato Root Response toBoron ToxicityYear:2009Source:Plant Sci. 176(4): 545-552Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Garden TomatoGROWGHT HYP(Solanum lycopersicum)GRO16. d TNOAEL: 0.5 mMLOAEL: 2 mM1 100 LAB DA 5.8*Orig0.5 mMOrig2 mMSL42 dMonday, June 15, 2015Page 36 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166604Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cervilla LM;Rosales MA;Rubio-Wilhelmi MM;Sanchez-Rodriguez E;Blasco B;Rios JJ;RomeroL;Ruiz JMTitle:Involvement of Lignification and Membrane Permeability in the Tomato Root Response toBoron ToxicityYear:2009Source:Plant Sci. 176(4): 545-552Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Garden TomatoGROWGHT HYP(Solanum lycopersicum)GRO16. d TNOAEL: 0.5 mMLOAEL: 2 mM1 100 LAB DA 5.8*Orig0.5 mMOrig2 mMSL42 dRef #166672Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Shann JR;Adriano DCTitle:The Chronic Exposure of SelectedCrop Species to Boron AerosolsYear:1988Source:Environ. Exp. Bot. 28(4): 289-300Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.ChardGROAREA HYP(Beta vulgaris ssp. cicla)GRO35. d TNOAEL: 3.09 ug/cm2NR1 100 LAB SPOrig3.09 ug/cm2Origug/cm2SL3 dChardGROAREA NAT(Beta vulgaris ssp. cicla)GRO35. d TNOAEL: 3.09 ug/cm2NR1 100 LAB SP 6.2*Orig3.09 ug/cm2Origug/cm2SL3 dCucumberGROWGHT HYP(Cucumis sativus)GRO28. d TNOAEL: 50 mMNR1 100 LAB SPOrig50 mMOrigmMSL3 dCucumberGROWGHT HYP(Cucumis sativus)GRO28. d TNOAEL: 0.05 mMLOAEL: 1 mM1 100 LAB DAOrig0.05 mMOrig1 mMSL3 dCucumberGROWGHT HYP(Cucumis sativus)GRO28. d TNOAEL: 0.05 mMLOAEL: 1 mM1 100 LAB MUOrig0.05 mMOrig1 mMSL3 dRadishGROAREA NAT(Raphanus sativus)GRO35. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SP 6.2*Orig1.55 ug/cm2Origug/cm2SL3 dMonday, June 15, 2015Page 37 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166672Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Shann JR;Adriano DCTitle:The Chronic Exposure of SelectedCrop Species to Boron AerosolsYear:1988Source:Environ. Exp. Bot. 28(4): 289-300Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.RadishGROWGHT HYP(Raphanus sativus)GRO35. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SPOrig1.55 ug/cm2Origug/cm2SL3 dRadishPHYGINJ HYP(Raphanus sativus)INJ35. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SPOrig1.55 ug/cm2Origug/cm2SL3 dSugar BeetGROAREA NAT(Beta vulgaris)GRO49. d TNOAEL: 1.55 ug/cm2LOAEL: 3.09 ug/cm2 1 100 LAB SP 6.2*Orig1.55 ug/cm2Orig3 ug/cm2SL3 dSugar Beet GRO WGHT HYP(Beta vulgaris)GRO 49. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SPOrig1.55 ug/cm2Origug/cm2SL3 dTomatoGROWGHT HYP(Solanum lycopersicumlycopersicum)GRO28. d TNOAEL: 0.05 mMLOAEL: 1 mM1 100 LAB DAOrig0.05 mMOrig1 mMSL3 dTomatoGROWGHT HYP(Solanum lycopersicumlycopersicum)GRO28. d TNOAEL: 50 mMNR1 100 LAB SPOrig50 mMOrigmMSL3 dTomatoPHYGINJ HYP(Solanum lycopersicumlycopersicum)INJ28. d TLOAEL: 50 mMNR1 100 LAB SPOrig50 mMOrigmMSL3 dTomatoPHYGINJ HYP(Solanum lycopersicumlycopersicum)INJ28. d TNOAEL: 0.05 mMLOAEL: 1 mM1 100 LAB DAOrig0.05 mMOrig1 mMSL3 dTomatoPHYGINJ HYP(Solanum lycopersicumlycopersicum)INJ28. d TNOAEL: 0.05 mMLOAEL: 1 mM1 100 LAB MUOrig0.05 mMOrig1 mMSL3 dMonday, June 15, 2015Page 38 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166700Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eraslan F;Inal A;Pilbeam DJ;Gunes ATitle:Interactive Effects of Salicylic Acid and Silicon on Oxidative Damage and Antioxidant Activity inSpinach (Spinacia oleracea L. cv. matador) Grown Under Boron Toxicity and SalinityYear:2008Source:Plant Growth Regul. 55(3): 207-219Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SpinachGROWGHT NAT(Spinacia oleracea)GRO69. d TNOAEL: 50 mg/kg d soiNR1 100 LAB DA 7.91*Orig50 mg/kg d soilOrigmg/kg d soil13 dppRef #166739Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Bagheri A;Paull JG;Rathgen AJ;Ali SM;Moody DBTitle:Genetic Variation in the Response of Peas (Pisum sativum L.) to High Soil Concentrations ofBoronYear:1992Source:Plant Soil 146: 261-269Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.PeaGROHGHT NAT(Pisum sativum)GRO45. d TNOAEL: 40 ppmNR1 100 LAB DAOrig40 mg/kgOrigmg/kgSDPeaGROHGHT NAT(Pisum sativum)GRO45. d TNOAEL: 40 ppmNR1 100 LAB DAOrig40 mg/kgOrigmg/kgSDPeaGROHGHT NAT(Pisum sativum)GRO45. d TNOAEL: 40 ppmNR1 100 LAB DAOrig40 mg/kgOrigmg/kgSDPeaGROHGHT NAT(Pisum sativum)GRO45. d TNOAEL: 40 ppmNR1 100 LAB DAOrig40 mg/kgOrigmg/kgSDPeaGROHGHT NAT(Pisum sativum)GRO45. d TNOAEL: 40 ppmNR1 100 LAB DAOrig40 mg/kgOrigmg/kgSDPeaGROHGHT NAT(Pisum sativum)GRO45. d TNOAEL: 40 ppmNR1 100 LAB DAOrig40 mg/kgOrigmg/kgSDMonday, June 15, 2015Page 39 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166739Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Bagheri A;Paull JG;Rathgen AJ;Ali SM;Moody DBTitle:Genetic Variation in the Response of Peas (Pisum sativum L.) to High Soil Concentrations ofBoronYear:1992Source:Plant Soil 146: 261-269Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.PeaGROHGHT NAT(Pisum sativum)GRO45. d TNOAEL: 40 ppmNR1 100 LAB DAOrig40 mg/kgOrigmg/kgSDPeaGRONODE NAT(Pisum sativum)GRO21. d TLOAEL: 20 ppmNR1 100 LAB DAOrig20 mg/kgOrigmg/kgSDPeaGRONODE NAT(Pisum sativum)GRO21. d TLOAEL: 20 ppmNR1 100 LAB DAOrig20 mg/kgOrigmg/kgSDPeaGRONODE NAT(Pisum sativum)GRO21. d TNOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaGRONODE NAT(Pisum sativum)GRO21. d TNOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDMonday, June 15, 2015Page 40 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166739Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Bagheri A;Paull JG;Rathgen AJ;Ali SM;Moody DBTitle:Genetic Variation in the Response of Peas (Pisum sativum L.) to High Soil Concentrations ofBoronYear:1992Source:Plant Soil 146: 261-269Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.PeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaPHYDAMG NAT(Pisum sativum)INJ21. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDRef #166744Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Choi JM;Pak CH;Lee CWTitle:Micronutrient Toxicity in French MarigoldYear:1996Source:J. Plant Nutr. 19(6): 901-916Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.French MarigoldGROHGHT ART(Tagetes patula)GRO35. d TNOAEL: 1 mMLOAEL: 2 mM1 100 LAB WA 6.8 to7.3Orig1 mMOrig2 mMSLFrench MarigoldGROWGHT ART(Tagetes patula)GRO35. d TNOAEL: 0.25 mMLOAEL: 0.5 mM1 100 LAB WA 6.8 to7.3Orig0.25 mMOrig0 mMSLFrench MarigoldGROWGHT ART(Tagetes patula)GRO35. d TNOAEL: 0.25 mMLOAEL: 0.5 mM1 100 LAB WA 6.8 to7.3Orig0.25 mMOrig0 mMSLMonday, June 15, 2015Page 41 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166751Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Swietlik DTitle:Interaction Between Zinc Deficiency and Boron Toxicity on Growth and Mineral Nutrition ofSour Orange SeedlingsYear:1995Source:J. Plant Nutr. 18(6): 1191-1207Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Sour OrangeGROWGHT CUL(Citrus aurantium)GRO90. d TNOAEL: 200 uMNR1 100 LAB HP 6.0*Orig200 uMOriguMSL~7.5 moSour OrangeGROWGHT CUL(Citrus aurantium)GRO90. d TNOAEL: 200 uMNR1 100 LAB HP 6.0*Orig200 uMOriguMSL~7.5 moRef #166762Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Poulain D;Al Mohammad HTitle:Effects of Boron Deficiency and Toxicity on Faba Bean (Vicia faba L.)Year:1995Source:Eur. J. Agron. 4(1): 127-134Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BroadbeanGROHGHT ART(Vicia faba)GRO118. d TNOAEL: 8 ppmLOAEL: 32 ppm2 100 LAB WAOrig8 mg/LOrig32 mg/LSL30 dppRef #166775Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gunes A;Inal A;Bagci EG;Coban S;Pilbeam DJTitle:Silicon Mediates Changes to some Physiological and Enzymatic Parameters Symptomatic forOxidative Stress in Spinach (Spinacia oleracea L.) Grown Under B ToxicityYear:2007Source:Sci. Hortic. 113(2): 113-119Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SpinachGROWGHT NAT(Spinacia oleracea)GRO87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDMonday, June 15, 2015Page 42 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166775Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gunes A;Inal A;Bagci EG;Coban S;Pilbeam DJTitle:Silicon Mediates Changes to some Physiological and Enzymatic Parameters Symptomatic forOxidative Stress in Spinach (Spinacia oleracea L.) Grown Under B ToxicityYear:2007Source:Sci. Hortic. 113(2): 113-119Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SpinachGROWGHT NAT(Spinacia oleracea)GRO87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDRef #166778Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eraslan F;Inal A;Gunes A;Alpaslan MTitle:"Impact of Exogenous Salicylic Acid on the Growth, Antioxidant Activity and Physiology ofCarrot Plants Subjected to Combined Salinity and Boron Toxicity"Year:2007Source:Sci. Hortic. 113(2): 120-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Wild CarrotGROWGHT NAT(Daucus carota)GRO~182.64 d TNOAEL: 25 mg/kg d soiNR1 100 LAB DA 7.91*Orig25 mg/kg d soilOrigmg/kg d soilSDRef #166781Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Molassiotis A;Sotiropoulos T;Tanou G;Diamantidis G;Therios ITitle:Boron-Induced Oxidative Damage and Antioxidant and Nucleolytic Responses in Shoot TipsCulture of the Apple Rootstock EM 9 (Malus domestica Borkh)Year:2006Source:Environ. Exp. Bot. 56(1): 54-62Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Paradise AppleGROWGHT CUL(Malus pumila)GRO20. d TNOAEL: 3 mMLOAEL: 6 mM1 100 LAB DA 5.8Orig3 mMOrig6 mMMonday, June 15, 2015Page 43 of 43Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Table 2 for Terrestrial Plant Studies (species not comparable)Boric Acid CaseCAS Number:1303964PC Code:Download Date:11/4/2014Other terrestrial plants and fungiTaxa_Code:OTPAcuteRef #106843Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Amadioha ACTitle:Control of Storage Rot of Potato Caused by Rhizopus oryzaeYear:1996Source:Int. J. Pest Manag. 42(4): 311-314Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungusGROGRRT AGR(Rhizopus oryzae)GRO5. d TLD50: 11251 ppmNR3 100 LAB DAOrig11251 ai ppmOrigai ppmRef #150120Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Pisani T;Munzi S;Paoli L;Backor M;Loppi STitle:Physiological Effects of a Geothermal Element: Boron Excess in the Epiphytic Lichen Xanthoriaparietina (L.) TH. FR.Year:2009Source:Chemosphere 76(7): 921-926Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Maritime Sunburst LichenPHYDAMG HYP(Xanthoria parietina)INJ1. d TNOAEL: 1 ppmLOAEL: 10 ppm1 100 LAB HPOrig1 ppmOrig10 ppmMonday, June 15, 2015Page 1 of 1Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Table 3 for Terrestrial Plant Studies (endpoints not comparable)Boric Acid CaseCAS Number:17024372PC Code:Download Date:11/4/2014Terrestrial monocotsTaxa_Code:MTPOtherRef #54776Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Temesagdie P;Takano TTitle:"Effect of Treated Seeds with H2BO3, GA3, KNO3 and ZnSO4 on Seedling Growth of SweetCorn and Yard Long Bean"Year:1992Source:Kasetsart J. Nat. Sci. 26(5): 34-40Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.CornGROLGTH FLT(Zea mays)MPH10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDCornGROLGTH FLT(Zea mays)MPH10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDCornGROLGTH FLT(Zea mays)MPH10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDCornREPGERM FLT(Zea mays)REP10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDCornREPGERM FLT(Zea mays)REP10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDCornREPGERM FLT(Zea mays)REP10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDMonday, June 15, 2015Page 1 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #56070Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Adriano DC;Kaplan DI;Burkman WG;Mills GLTitle:Long-Term Phytoavailability of Soil-Applied Organo-BoratesYear:1988Source:J. Environ. Qual. 17(3): 485-492Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SudangrassACCRSDE NAT(Sorghum bicolor ssp. drummondii)ACChv TLOAEL: 4 ppmNR2 100 LAB ENOrig4 mg/kgOrigmg/kgSDSudangrassACCRSDE NAT(Sorghum bicolor ssp. drummondii)ACChv TLOAEL: 4 ppmNR4 100 LAB ENOrig4 mg/kgOrigmg/kgSDRef #56216Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Clark RB;Pier PA;Knudsen D;Maranville JWTitle:Effect of Trace Element Deficiencies and Excesses on Mineral Nutrients in SorghumYear:1981Source:J. Plant Nutr. 3(1-4): 357-374Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BroomcornACCRSDE CUL(Sorghum bicolor)ACC10. d TLOAEL: 4.5 mmol/LNR1 100 LAB CMOrig4.5 mmol/LOrigmmol/LSL2 to 3 lsRef #57592Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Saric T;Saciragic BTitle:Effect of Oat Seed Treatment with MicroelementsYear:1969Source:Plant Soil 31(1): 185-187Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.OatGROSTRC NAT(Avena sp.)MPH80. d TLOAEL: 0.02 %NR2 100 FIELDN SOOrig0.02 %Orig%SDOatPOPBMAS NAT(Avena sp.)POP154. d TNOAEL: 0.02 %NR2 100 FIELDN SOOrig0.02 %Orig%SDMonday, June 15, 2015Page 2 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #57592Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Saric T;Saciragic BTitle:Effect of Oat Seed Treatment with MicroelementsYear:1969Source:Plant Soil 31(1): 185-187Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.OatREPGERM NAT(Avena sp.)REPgm TNOAEL: 0.02 %NR2 100 FIELDN SOOrig0.02 %Orig%SDRef #59517Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kluge R;Podlesak WTitle:Plant Critical Levels for the Evaluation of Boron Toxicity in Spring Barley (Hordeum vulgare L.)Year:1985Source:Plant Soil 83: 381-388Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyPOPBMAS NAT(Hordeum vulgare)POPhv TNOAEL: 308 ppmNR1 100 LAB PR 5.2 to5.6Orig308 mg/kg dry wtOrigmg/kg dry wtSDBarleyPOPBMAS NAT(Hordeum vulgare)POPhv TNOAEL: 55 ppmNR1 100 LAB PR 5.2 to5.6Orig55 mg/kg dry wtOrigmg/kg dry wtSDBarleyPOPBMAS NAT(Hordeum vulgare)POPhv TNOAEL: 120 ppmNR1 100 LAB PR 5.2 to5.6Orig120 mg/kg dry wtOrigmg/kg dry wtSDBarleyPOPBMAS NAT(Hordeum vulgare)POPhv TNOAEL: 124 ppmNR1 100 LAB PR 5.2 to5.6Orig124 mg/kg dry wtOrigmg/kg dry wtSDBarleyPOPBMAS NAT(Hordeum vulgare)POPhv TNOAEL: 227 ppmNR1 100 LAB PR 5.2 to5.6Orig227 mg/kg dry wtOrigmg/kg dry wtSDMonday, June 15, 2015Page 3 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #66651Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yau SK;Nachit M;Ryan JTitle:"Variation in Growth, Development, and Yield of Durum Wheat in Response to High Soil Boron.II. Differences Between Genotypes"Year:1997Source:Aust. J. Agric. Res. 48(7): 951-957Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Durum WheatGROSTGE UKS(Triticum durum)DVPma TNOAEL: 17.4 ppmNR2 100 LAB DAOrig17.4 mg/kgOrigmg/kgDurum WheatGROTHED UKS(Triticum durum)DVPd TLOAEL: 7.1 ppmNR2 100 LAB DAOrig7.1 mg/kgOrigmg/kgDurum WheatGROTHED UKS(Triticum durum)DVPd TNOAEL: 17.4 ppmNR2 100 LAB DAOrig17.4 mg/kgOrigmg/kgDurum WheatGROTHED UKS(Triticum durum)DVP~95. d TNOAEL: 7.1 ppmLOAEL: 17.4 ppm2 100 LAB DAOrig7.1 mg/kgOrig17 mg/kgRef #67244Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Davis JG;Hossner LR;Persaud NTitle:Elemental Toxicity Effects on Germination and Growth of Pearl Millet SeedlingsYear:1993Source:J. Plant Nutr. 16(10): 1957-1968Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Pearl MilletREPGERM FLT(Pennisetum glaucum)REP<7. d TNOAEL: 0.01 MNR1 100 LAB DAOrig0.01 MOrigMSDPearl MilletREPGERM FLT(Pennisetum glaucum)REP<7. d TNOAEL: 0.01 MNR1 100 LAB DAOrig0.01 MOrigMSDPearl MilletREPGERM FLT(Pennisetum glaucum)REP<7. d TNOAEL: 0.01 MNR1 100 LAB DAOrig0.01 MOrigMSDMonday, June 15, 2015Page 4 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #71184Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Karabal E;Yucel M;Oktem HATitle:Antioxidant Responses of Tolerant and Sensitive Barley Cultivars to Boron ToxicityYear:2003Source:Plant Sci. 164(6): 925-933Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyBCMASCP MIX(Hordeum vulgare)ENZ5. d TLOAEL: 5 mMNR2 100 LAB DAOrig5 mMOrigmMSL8 dBarleyBCMASCP MIX(Hordeum vulgare)ENZ5. d TLOAEL: 5 mMNR2 100 LAB DAOrig5 mMOrigmMSL8 dBarleyBCMMLDH MIX(Hordeum vulgare)BCM5. d TLOAEL: 5 mMNR2 100 LAB DAOrig5 mMOrigmMSL8 dBarleyBCMMLDH MIX(Hordeum vulgare)BCM5. d TLOAEL: 5 mMNR2 100 LAB DAOrig5 mMOrigmMSL8 dRef #96218Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Simoglou KB;Dordas CTitle:"Effect of Foliar Applied Boron, Manganese and Zinc on Tan Spot in Winter Durum Wheat"Year:2006Source:Crop Prot. 25(7): 657-663Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Durum WheatPOPBMAS NAT(Triticum durum)POPhv TNOAEL: 6.25 ppmNR1 100 FIELDN FS 8.15Orig6.25 mg/LOrigmg/LRef #101637Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Turkoglu STitle:Genotoxicity of Five Food Preservatives Tested on Root Tips of Allium cepa L.Year:2007Source:Mutat. Res. 626(1-2): 4-14Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 5 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #101637Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Turkoglu STitle:Genotoxicity of Five Food Preservatives Tested on Root Tips of Allium cepa L.Year:2007Source:Mutat. Res. 626(1-2): 4-14Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Common OnionCELMITA HYP(Allium cepa)GEN0.417 d TLOAEL: 20 ppmNR5 100 LAB HPOrig20 ppmOrigppmGSCommon OnionCELMITA HYP(Allium cepa)GEN0.833 d TLOAEL: 20 ppmNR5 100 LAB HPOrig20 ppmOrigppmGSCommon OnionCELMITA HYP(Allium cepa)GEN0.208 d TLOAEL: 20 ppmNR5 100 LAB HPOrig20 ppmOrigppmGSRef #104993Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Nuttall JG;Armstrong RD;Connor DJTitle:Early Growth of Wheat is More Sensitive to Salinity than Boron at Levels Encountered inAlkaline Soils of South-Eastern AustraliaYear:2006Source:Aust. J. Exp. Agric. 46(11): 1507-1514Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatACCRSDE NAT(Triticum aestivum)ACC49. d TNOAEL: 20 ppmLOAEL: 40 ppm4 100 LAB HP 7.82 to8.01Orig20 mg/kgOrig40 mg/kgSDBread WheatBCMNACO NAT(Triticum aestivum)BCM49. d TNOAEL: 160 ppmNR4 100 LAB HP 7.82 to8.01Orig160 mg/kgOrigmg/kgSDBread WheatGROLGTH NAT(Triticum aestivum)MPH49. d TNOAEL: 20 ppmLOAEL: 40 ppm4 100 LAB HP 7.82 to8.01Orig20 mg/kgOrig40 mg/kgSDBread WheatGROLGTH NAT(Triticum aestivum)MPH49. d TNOAEL: 80 ppmLOAEL: 160 ppm4 100 LAB HP 7.82 to8.01Orig80 mg/kgOrig160 mg/kgSDBread WheatGROLGTH NAT(Triticum aestivum)MPH49. d TNOAEL: 40 ppmLOAEL: 80 ppm4 100 LAB HP 7.82 to8.01Orig40 mg/kgOrig80 mg/kgSDMonday, June 15, 2015Page 6 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105883Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Anaka A;Wickstrom M;Siciliano SDTitle:"Increased Sensitivity and Variability of Phytotoxicity Responses in Arctic Soils to a ReferenceToxicant, Boric Acid"Year:2008Source:Environ. Toxicol. Chem. 27(3): 720-726Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Streambank WheatgrassGROEMRG NAT(Elymus lanceolatus)DVP21. d TIC20: 402 ppmNR7 100 LAB DA 4.4Orig402 ug/g soilOrigug/g soilSDStreambank WheatgrassGROEMRG NAT(Elymus lanceolatus)DVP21. d TIC20: 554 ppmNR7 100 LAB DA 4.4Orig554 ug/g soilOrigug/g soilSDStreambank WheatgrassGROEMRG NAT(Elymus lanceolatus)DVP21. d TIC20: 55 ppmNR7 100 LAB DA 4.4Orig55 ug/g soilOrigug/g soilSDRef #106676Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yau SK;Saxena MCTitle:"Variation in Growth, Development, and Yield of Durum Wheat in Response to High Soil Boron.I. Average Effects"Year:1997Source:Aust. J. Agric. Res. 48(7): 945-949Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Durum WheatACCRSDE ART(Triticum durum)ACCstg TLOAEL: 7.1 ppmNR2 99.5 LAB DA 8.1Orig7.1 mg/kgOrigmg/kgSDDurum WheatGROEMRG ART(Triticum durum)DVP7. d TLOAEL: 7.1 ppmNR2 99.5 LAB DA 8.1Orig7.1 mg/kgOrigmg/kgSDMonday, June 15, 2015Page 7 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #108828Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rozema J;De Bruin J;Broekman RATitle:Effect of Boron on the Growth and Mineral Economy of Some Halophytes and Non-HalophytesYear:1992Source:New Phytol. 121(2): 249-256Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Tick QuackgrassACCRSDE HYP(Thinopyrum pycnanthum)ACC28. d TNOAEL: 0.025 mol/m3LOAEL: 0.35 mol/m3 1 100 LAB HP 6.5Orig0.025 mol/m3Orig0 mol/m3Tick Quackgrass BCM KCON HYP(Thinopyrum pycnanthum)BCM 28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Ref #151386Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aydin M;Cakir FTitle:Research on Weed Species for Phytoremediation of Boron Polluted SoilYear:2009Source:Afr. J. Biotechnol. 8(18): 4514-4518Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Barnyard GrassACCRSDE NAT(Echinochloa crus-galli)ACC35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDBarnyard GrassACCRSDE NAT(Echinochloa crus-galli)ACC35. d TNOAEL: 20 ppmLOAEL: 30 ppm1 100 LAB DA 7.87*Orig20 mg/kg soilOrig30 mg/kg soilSDBarnyard GrassPOPWGHT NAT(Echinochloa crus-galli)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDBarnyard GrassPOPWGHT NAT(Echinochloa crus-galli)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDBermudagrassACCRSDE NAT(Cynodon dactylon)ACC35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHBermudagrassACCRSDE NAT(Cynodon dactylon)ACC35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHMonday, June 15, 2015Page 8 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #151386Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aydin M;Cakir FTitle:Research on Weed Species for Phytoremediation of Boron Polluted SoilYear:2009Source:Afr. J. Biotechnol. 8(18): 4514-4518Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BermudagrassPOPWGHT NAT(Cynodon dactylon)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHBermudagrassPOPWGHT NAT(Cynodon dactylon)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHJohnson GrassACCRSDE NAT(Sorghum halepense)ACC35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHJohnson GrassACCRSDE NAT(Sorghum halepense)ACC35. d TNOAEL: 10 ppmLOAEL: 20 ppm1 100 LAB DA 7.87*Orig10 mg/kg soilOrig20 mg/kg soilRHJohnson GrassPOPWGHT NAT(Sorghum halepense)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHJohnson GrassPOPWGHT NAT(Sorghum halepense)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHPurple NutsedgeACCRSDE NAT(Cyperus rotundus)ACC35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHPurple NutsedgeACCRSDE NAT(Cyperus rotundus)ACC35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHPurple NutsedgePOPWGHT NAT(Cyperus rotundus)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHPurple NutsedgePOPWGHT NAT(Cyperus rotundus)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilRHMonday, June 15, 2015Page 9 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #159071Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Chernobrovkina NP;Titov AF;Robonen EV;Morozov AKTitle:Effect of Boric Acid on the Ability of Plants to Accumulate Heavy MetalsYear:2012Source:Russ. J. Ecol. 43(1): 29-32Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.TimothyPHYNIUP NAT(Phleum pratense)PHYstg TNOAEL: 0.0892 lb/acreLOAEL: 0.2676 lb/acre 1 100 FIELDN DAOrig0.1 kg/haOrig0 kg/haRef #166365Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Esim N;Tiryaki D;Karadagoglu O;Atici OTitle:Toxic Effects of Boron on Growth and Antioxidant System Parameters of Maize (Zea mays L.)RootsYear:2013Source:Toxicol. Ind. Health 29(9): 800-805Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CornBCMMLDH HYP(Zea mays)BCM2. d TLOAEL: 2 mMNR1 100 LAB HPOrig2 mMOrigmMSL9 dCornBCMSODA HYP(Zea mays)ENZ2. d TLOAEL: 2 mMNR1 100 LAB HPOrig2 mMOrigmMSL9 dRef #166383Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:El-Feky SS;El-Shintinawy FA;Shaker EM;El-Din HASTitle:Effect of Elevated Boron Concentrations on the Growth and Yield of Barley (Hordeum vulgareL.) and Alleviation of Its Toxicity Using Different Plant Growth ModulatorsYear:2012Source:Aust. J. Crop Sci. 6(12): 1687-1695Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyACCRSDE NAT(Hordeum vulgare)ACC92. d TLOAEL: 0.5 ppmNR1 100 LAB DA 7.5*Orig0.5 mg/LOrigmg/LGPSMonday, June 15, 2015Page 10 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166383Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:El-Feky SS;El-Shintinawy FA;Shaker EM;El-Din HASTitle:Effect of Elevated Boron Concentrations on the Growth and Yield of Barley (Hordeum vulgareL.) and Alleviation of Its Toxicity Using Different Plant Growth ModulatorsYear:2012Source:Aust. J. Crop Sci. 6(12): 1687-1695Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyBCMCHLA NAT(Hordeum vulgare)BCM45. d TLOAEL: 0.5 ppmNR1 100 LAB DA 7.5*Orig0.5 mg/LOrigmg/LGPSBarleyGROAREA NAT(Hordeum vulgare)MPH45. d TLOAEL: 0.5 ppmNR1 100 LAB DA 7.5*Orig0.5 mg/LOrigmg/LGPSBarleyPOPWGHT NAT(Hordeum vulgare)POP92. d TNOAEL: 1.5 ppmLOAEL: 3 ppm1 100 LAB DA 7.5*Orig1.5 mg/LOrig3 mg/LGPSRef #166389Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Turan MA;Taban N;Taban STitle:Effect of Calcium on the Alleviation of Boron Toxicity and Localization of Boron and Calcium inCell Wall of WheatYear:2009Source:Notulae Bot. Horti Agrobot. Cluj-Napoca 37(2): 99-103Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatACCRSDE NAT(Triticum aestivum)ACC60. d TLOAEL: 5 ppmNR1 100 LAB DA 8.08*Orig5 mg/kgOrigmg/kgSDBread WheatBCMCACO NAT(Triticum aestivum)BCM60. d TLOAEL: 5 ppmNR1 100 LAB DA 8.08*Orig5 mg/kgOrigmg/kgSDBread WheatPHYCAUP NAT(Triticum aestivum)PHY60. d TLOAEL: 5 ppmNR1 100 LAB DA 8.08*Orig5 mg/kgOrigmg/kgSDMonday, June 15, 2015Page 11 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166401Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hosseini SM;Maftoun M;Karimian N;Ronaghi A;Emam YTitle:Effect of Zinc x Boron Interaction on Plant Growth and Tissue Nutrient Concentration of CornYear:2007Source:J. Plant Nutr. 30: 773-781Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CornACCRSDE NAT(Zea mays)ACC70. d TLOAEL: 2.5 ppmNR1 100 LAB DA 7.5*Orig2.5 ug/gOrigug/gSDPOCornBCMPCON NAT(Zea mays)BCM70. d TLOAEL: 2.5 ppmNR1 100 LAB DA 7.5*Orig2.5 ug/gOrigug/gSDPORef #166407Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Zhang J;Wang M;Wu L;Wu J;Shi CTitle:Impacts of Combination of Foliar Iron and Boron Application on Iron Biofortification andNutritional Quality of Rice GrainYear:2008Source:J. Plant Nutr. 31: 1599-1611Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.RiceBCMPRCO ART(Oryza sativa)BCM64. d TLOAEL: 0.2 % w/vNR1 100 FIELDA FS 5.7Orig0.2 % w/vOrig% w/vRef #166434Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Martinez-Ballesta MC;Bastias E;Zhu C;Schaffner AR;Gonzalez-Moro B;Gonzalez-MuruaC;Carvajal MTitle:"Boric Acid and Salinity Effects on Maize Roots. Response of Aquaporins ZmPIP1 andZmPIP2, and Plasma Membrane H+-ATPase, in Relation to Water and Nutrient Uptake"Year:2008Source:Physiol. Plant. 132(4): 479-490Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CornACCASMC NR(Zea mays)ACC5. d TLOAEL: 3.6 nMNR1 100 LAB ENOrig3.6 nMOrignM3 wkMonday, June 15, 2015Page 12 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166434Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Martinez-Ballesta MC;Bastias E;Zhu C;Schaffner AR;Gonzalez-Moro B;Gonzalez-MuruaC;Carvajal MTitle:"Boric Acid and Salinity Effects on Maize Roots. Response of Aquaporins ZmPIP1 andZmPIP2, and Plasma Membrane H+-ATPase, in Relation to Water and Nutrient Uptake"Year:2008Source:Physiol. Plant. 132(4): 479-490Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CornBCMATPA NR(Zea mays)ENZ5. d TNOAEL: 3.6 nMNR1 100 LAB ENOrig3.6 nMOrignM3 wkCornBCMCACO NR(Zea mays)BCM5. d TLOAEL: 3.6 nMNR1 100 LAB ENOrig3.6 nMOrignM3 wkRef #166601Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Nelson DR;Mele PMTitle:Subtle Changes in Rhizosphere Microbial Community Structure in Response to IncreasedBoron and Sodium Chloride ConcentrationsYear:2007Source:Soil Biol. Biochem. 39(1): 340-351Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatGRODVLP NAT(Triticum aestivum)DVP35. d TLOAEL: 12 ppmNR1 100 LAB DA 8.0*Orig12 ug/g d soilOrigug/g d soilSLBread WheatGRODVLP NAT(Triticum aestivum)DVP42. d TLOAEL: 12 ppmNR1 100 LAB DA 8.0*Orig12 ug/g d soilOrigug/g d soilSLBread WheatGRODVLP NAT(Triticum aestivum)DVPd TNOAEL: 12 ppmLOAEL: 24 ppm1 100 LAB DA 8.0*Orig12 ug/g d soilOrig24 ug/g d soilSLBread WheatGRODVLP NAT(Triticum aestivum)DVP<=21. d TNOAEL: 24 ppmNR1 100 LAB DA 8.0*Orig24 ug/g d soilOrigug/g d soilSLBread WheatPOPBMAS NAT(Triticum aestivum)POP42. d TLOAEL: 12 ppmNR1 100 LAB DA 8.0*Orig12 ug/g d soilOrigug/g d soilSLMonday, June 15, 2015Page 13 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166641Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Westlund A;Nohrstedt HOTitle:Effects of Stump-Treatment Substances for Root-Rot Control on Ground Vegetation and SoilProperties in a Picea abies Forest in SwedenYear:2000Source:Scand. J. For. Res. 15(5): 550-560Test Chemical:Boron sodium oxide(B8Na2O13) tetrahydrateCAS Number:12280034Lifestage:AgeFormul.Wavy HairgrassPOPCOVR NAT(Deschampsia flexuosa)POP365. d TNOAEL: 0.3-6.1 g/m2NR1 100 FIELDN DAOrigOrigg/m2SRef #166643Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Wilkinson SRTitle:Response of Tifway 2 Bermudagrass to Fresh or Composed Broiler Litter Containing Boric AcidTreated Paper BeddingYear:1997Source:Commun. Soil Sci. Plant Anal. 28(3-5): 259-279Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BermudagrassACCRSDE NAT(Cynodon dactylon)ACC104. d TNOAEL: 6.78 lb/acreLOAEL: 19.9808 lb/acr 2 100 LAB EN 4.9Orig7.6 kg/haOrig22 kg/haBermudagrass PHY PTRN NAT(Cynodon dactylon)PHY 104. d TNOAEL: 19.98 lb/acreNR2 100 LAB EN 4.9Orig22.4 kg/haOrigkg/haBermudagrassPOPBMAS NAT(Cynodon dactylon)POP104. d TNOAEL: 6.78 lb/acreLOAEL: 19.9808 lb/acr 2 100 LAB EN 4.9Orig7.6 kg/haOrig22 kg/haRef #166644Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yau SK;Nachit MM;Ryan J;Hamblin JTitle:Phenotypic Variation in Boron-Toxicity Tolerance at Seedling Stage in Durum Wheat (Triticumdurum)Year:1995Source:Euphytica 83(3): 185-191Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 14 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166644Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yau SK;Nachit MM;Ryan J;Hamblin JTitle:Phenotypic Variation in Boron-Toxicity Tolerance at Seedling Stage in Durum Wheat (Triticumdurum)Year:1995Source:Euphytica 83(3): 185-191Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Durum WheatREPGERM ART(Triticum durum)REP6. d TNOAEL: 36.3 ppmNR1 100 LAB DAOrig36.3 ppmOrigppmSDRef #166668Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ochiai K;Uemura S;Shimizu A;Okumoto Y;Matoh TTitle:Boron Toxicity in Rice (Oryza sativa L.). I. Quantitative Trait Locus (QTL) Analysis of Toleranceto Boron ToxicityYear:2008Source:Theor. Appl. Genet. 117(1): 125-133Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.RicePOPBMAS NAT(Oryza sativa)POP130. d TLOAEL: 10 ppmNR1 100 LAB WAOrig10 g/m3Origg/m3SL18 dRicePOPBMAS NAT(Oryza sativa)POP130. d TLOAEL: 10 ppmNR1 100 LAB WAOrig10 g/m3Origg/m3SL18 dRicePOPBMAS NAT(Oryza sativa)POP155. d TNOAEL: 10 ppmLOAEL: 30 ppm1 100 LAB WAOrig10 g/m3Orig30 g/m3SL18 dRiceREPINFL NAT(Oryza sativa)REP130. d TLOAEL: 10 ppmNR1 100 LAB WAOrig10 g/m3Origg/m3SL18 dRiceREPINFL NAT(Oryza sativa)REP130. d TLOAEL: 10 ppmNR1 100 LAB WAOrig10 g/m3Origg/m3SL18 dRiceREPINFL NAT(Oryza sativa)REP155. d TNOAEL: 3 ppmLOAEL: 10 ppm1 100 LAB WAOrig3 g/m3Orig10 g/m3SL18 dMonday, June 15, 2015Page 15 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166713Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kalayci M;Alkan A;Cakmak I;Bayramoglu O;Yilmaz A;Aydin M;Ozbek V;Ekiz H;Ozberisoy FTitle:Studies on Differential Responses ofWheat Cultivars to Boron ToxicityYear:1998Source:Euphytica 100(1-3): 123-129Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.WheatPOPBMAS NAT(Triticum sp.)POPhv TLOAEL: 89.2 lb/acreNR1 100 FIELDN GGOrig100 kg/haOrigkg/haSDWheatPOPBMAS NAT(Triticum sp.)POPhv TNOAEL: 89.2 lb/acreNR1 100 FIELDN GGOrig100 kg/haOrigkg/haSDRef #166716Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Roessner U;Patterson JH;Forbes MG;Fincher GB;Langridge P;Bacic ATitle:An Investigation of Boron Toxicity in Barley Using MetabolomicsYear:2006Source:Plant Physiol. 142(3): 1087-1101Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyBCMVALI HYP(Hordeum vulgare)BCM21. d TLOAEL: 200 uMNR1 100 LAB HPOrig200 uMOriguMSL2 to 3 dBarleyBCMVALI HYP(Hordeum vulgare)BCM21. d TLOAEL: 200 uMNR1 100 LAB HPOrig200 uMOriguMSL2 to 3 dRef #166728Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Lee CW;Jackson MB;Duysen ME;Freeman TP;Self JRTitle:Induced Micronutrient Toxicity in 'Touchdown' Kentucky BluegrassYear:1996Source:Crop Sci. 36(3): 705-712Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Kentucky BluegrassACCRSDE ART(Poa pratensis)ACC52. d TLOAEL: 0.5 mMNR1 100 LAB DAOrig0.5 mMOrigmMSLMonday, June 15, 2015Page 16 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166728Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Lee CW;Jackson MB;Duysen ME;Freeman TP;Self JRTitle:Induced Micronutrient Toxicity in 'Touchdown' Kentucky BluegrassYear:1996Source:Crop Sci. 36(3): 705-712Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Kentucky BluegrassCELVOLU ART(Poa pratensis)CEL52. d TLOAEL: 4 mMNR1 100 LAB DAOrig4 mMOrigmMSLKentucky BluegrassPOPWGHT ART(Poa pratensis)POP52. d TNOAEL: 1 mMLOAEL: 2 mM1 100 LAB DAOrig1 mMOrig2 mMSLRef #166732Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Singh JP;Dahiya DJ;Narwal RPTitle:Boron Uptake and Toxicity in Wheat in Relation to Zinc SupplyYear:1990Source:Fert. Res. 24(2): 105-110Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatACCRSDE NAT(Triticum aestivum)ACChv TLOAEL: 2.5 ppmNR1 100 FIELDA DA 8.1*Orig2.5 mg/kg soilOrigmg/kg soilSDBread WheatBCMCUCO NAT(Triticum aestivum)BCMhv TLOAEL: 2.5 ppmNR1 100 FIELDA DA 8.1*Orig2.5 mg/kg soilOrigmg/kg soilSDBread WheatPHYZNUP NAT(Triticum aestivum)PHYhv TLOAEL: 2.5 ppmNR1 100 FIELDA DA 8.1*Orig2.5 mg/kg soilOrigmg/kg soilSDBread WheatPOPBMAS NAT(Triticum aestivum)POPhv TLOAEL: 2.5 ppmNR1 100 FIELDA DA 8.1*Orig2.5 mg/kg soilOrigmg/kg soilSDMonday, June 15, 2015Page 17 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166733Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Mahboobi H;Yucel M;Oktem HATitle:Cell Wall Uronic Acid Concentrations of Resistant and Sensitive Cultivars of Wheat and BarleyUnder Boron ToxicityYear:2001Source:J. Plant Nutr. 24(12): 1965-1973Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyBCMGCAC CUL(Hordeum vulgare)BCM7. d TNOAEL: 10 mMNR1 100 LAB CMOrig10 mMOrigmMSL10 dBarleyBCMGCAC CUL(Hordeum vulgare)BCM7. d TNOAEL: 10 mMNR1 100 LAB CMOrig10 mMOrigmMSL10 dBread WheatBCMGCAC CUL(Triticum aestivum)BCM7. d TNOAEL: 10 mMNR1 100 LAB CMOrig10 mMOrigmMSL10 dBread WheatBCMGCAC CUL(Triticum aestivum)BCM7. d TNOAEL: 10 mMNR1 100 LAB CMOrig10 mMOrigmMSL10 dRef #166737Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Panwar BS;Gupta SP;Kala RTitle:Responses to Boron in Pearl Millet and Chickpea in a Pot Experiment with a Non-CalcareousSoil in IndiaYear:1998Source:Acta Agron. Hung. 46(4): 335-340Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Pearl MilletACCRSDE NAT(Pennisetum glaucum)ACCea TLOAEL: 0.25 ppmNR1 100 LAB DA 8.3*Orig0.25 mg/kg soilOrigmg/kg soilPearl MilletACCRSDE NAT(Pennisetum glaucum)ACCea TLOAEL: 0.1 % w/vNR1 100 LAB FS 8.3*Orig0.1 % w/vOrig% w/vTLSPearl MilletPOPBMAS NAT(Pennisetum glaucum)POPea TNOAEL: 2 ppmNR1 100 LAB DA 8.3*Orig2 mg/kg soilOrigmg/kg soilMonday, June 15, 2015Page 18 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166737Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Panwar BS;Gupta SP;Kala RTitle:Responses to Boron in Pearl Millet and Chickpea in a Pot Experiment with a Non-CalcareousSoil in IndiaYear:1998Source:Acta Agron. Hung. 46(4): 335-340Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Pearl MilletPOPBMAS NAT(Pennisetum glaucum)POPea TNOAEL: 0.2 % w/vNR1 100 LAB FS 8.3*Orig0.2 % w/vOrig% w/vTLSRef #166743Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Riley MM;Robson AD;Dellar GA;Gartrell JWTitle:Critical Toxic Concentrations of Boron are Variable in BarleyYear:1994Source:J. Plant Nutr. 17(10): 1701-1719Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyACCRSDE NAT(Hordeum vulgare)ACCbt TNOAEL: 0.5 ppmLOAEL: 1 ppm1 100 LAB DA 5.6*Orig0.5 ug/g soilOrig1 ug/g soilSDBarleyGRORATO NAT(Hordeum vulgare)MPHbt TNOAEL: 2 ppmLOAEL: 4 ppm1 100 LAB DA 5.6*Orig2 ug/g soilOrig4 ug/g soilSDBarleyPOPBMAS NAT(Hordeum vulgare)POPma TNOAEL: 4 ppmLOAEL: 8 ppm1 100 LAB DA 5.6*Orig4 ug/g soilOrig8 ug/g soilSDRef #166754Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hossain AKMZ;Asgar MDA;HossainMA;Tosaki T;Koyama H;Hara TTitle:Boron-Calcium Synergically Alleviates Aluminum Toxicity in Wheat Plants (Triticum aestivum L.)Year:2005Source:Soil Sci. Plant Nutr. 51(1): 43-49Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatACCRSDE HYP(Triticum aestivum)ACC8. d TLOAEL: 40 uMNR1 100 LAB HP 4.5Orig40 uMOriguMSL7 dMonday, June 15, 2015Page 19 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166754Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hossain AKMZ;Asgar MDA;HossainMA;Tosaki T;Koyama H;Hara TTitle:Boron-Calcium Synergically Alleviates Aluminum Toxicity in Wheat Plants (Triticum aestivum L.)Year:2005Source:Soil Sci. Plant Nutr. 51(1): 43-49Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bread WheatBCMPETN HYP(Triticum aestivum)BCM8. d TNOAEL: 40 uMNR1 100 LAB HP 4.5Orig40 uMOriguMSL7 dRef #166779Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Inal A;Pilbeam DJ;Gunes ATitle:Silicon Increases Tolerance to Boron Toxicity and Reduces Oxidative Damage in BarleyYear:2009Source:J. Plant Nutr. 32(1): 112-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyACCRSDE NAT(Hordeum vulgare)ACC73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDBarleyBCMANTO NAT(Hordeum vulgare)BCM73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDBarleyBCMASCP NAT(Hordeum vulgare)ENZ73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDBarleyBCMCTLS NAT(Hordeum vulgare)ENZ73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDBarleyBCMH2O2 NAT(Hordeum vulgare)BCM73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDBarleyBCMLPXG NAT(Hordeum vulgare)ENZ73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDBarleyBCMMLDH NAT(Hordeum vulgare)BCM73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDMonday, June 15, 2015Page 20 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166779Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Inal A;Pilbeam DJ;Gunes ATitle:Silicon Increases Tolerance to Boron Toxicity and Reduces Oxidative Damage in BarleyYear:2009Source:J. Plant Nutr. 32(1): 112-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BarleyBCMPRLN NAT(Hordeum vulgare)BCM73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDBarleyBCMSICO NAT(Hordeum vulgare)BCM73. d TNOAEL: 20 mg/kg d soiNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDBarleyBCMSODA NAT(Hordeum vulgare)ENZ73. d TLOAEL: 20 mg/kg d soilNR1 100 LAB DA 7.91*Orig20 mg/kg d soilOrigmg/kg d soilSDTerrestrial dicotsTaxa_Code:DTPOtherRef #54418Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Speir TW;August JA;Feltham CWTitle:"Assessment of the Feasibility of Using CCA (Copper, Chromium and Arsenic) - Treated andBoric Acid - Treated Sawdust as Soil Amendments I. Plant Growth and Element Uptake"Year:1992Source:Plant Soil 142(2): 235-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Dutch CloverBCMCUCO ART(Trifolium repens)BCM119. d TLOAEL: 36 ppmNR1 100 LAB EN 5Orig36 mg/kgOrigmg/kgSDDutch CloverBCMCUCO ART(Trifolium repens)BCM119. d TNOAEL: 36 ppmNR1 100 LAB EN 7Orig36 mg/kgOrigmg/kgSDDutch CloverPHYNFIX ART(Trifolium repens)PHY119. d TLOAEL: 36 ppmNR1 100 LAB EN 7Orig36 mg/kgOrigmg/kgSDMonday, June 15, 2015Page 21 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #54418Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Speir TW;August JA;Feltham CWTitle:"Assessment of the Feasibility of Using CCA (Copper, Chromium and Arsenic) - Treated andBoric Acid - Treated Sawdust as Soil Amendments I. Plant Growth and Element Uptake"Year:1992Source:Plant Soil 142(2): 235-248Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Dutch CloverPHYNFIX ART(Trifolium repens)PHY119. d TLOAEL: 36 ppmNR1 100 LAB EN 5Orig36 mg/kgOrigmg/kgSDSugar BeetBCMCUCO ART(Beta vulgaris)BCM77. d TNOAEL: 36 ppmNR1 100 LAB EN 7Orig36 mg/kgOrigmg/kgSDRef #54776Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Temesagdie P;Takano TTitle:"Effect of Treated Seeds with H2BO3, GA3, KNO3 and ZnSO4 on Seedling Growth of SweetCorn and Yard Long Bean"Year:1992Source:Kasetsart J. Nat. Sci. 26(5): 34-40Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.Yardlong BeanGROLGTH FLT(Vigna unguiculata ssp.sesquipedalis)MPH10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDYardlong BeanGROLGTH FLT(Vigna unguiculata ssp.sesquipedalis)MPH10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDYardlong BeanGROLGTH FLT(Vigna unguiculata ssp.sesquipedalis)MPH10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDYardlong BeanREPGERM FLT(Vigna unguiculata ssp.sesquipedalis)REP10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDMonday, June 15, 2015Page 22 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #54776Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Temesagdie P;Takano TTitle:"Effect of Treated Seeds with H2BO3, GA3, KNO3 and ZnSO4 on Seedling Growth of SweetCorn and Yard Long Bean"Year:1992Source:Kasetsart J. Nat. Sci. 26(5): 34-40Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.Yardlong BeanREPGERM FLT(Vigna unguiculata ssp.sesquipedalis)REP10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDYardlong BeanREPGERM FLT(Vigna unguiculata ssp.sesquipedalis)REP10. d TNOAEL: 9 ppmNR3 100 LAB ENOrig9 ppmOrigppmSDRef #62604Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Marcar NE;Guo J;Crawford DFTitle:"Response of Eucalyptus camaldulensis Dehnh., E. globulus Labill. ssp. globulus and E.grandis W.Hill to Excess Boron and Sodium Chloride"Year:1999Source:Plant Soil 208(2): 251-257Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Bluegum EucalyptusBCMNACO NAT(Eucalyptus globulus)BCM36. d TNOAEL: 0.93 mol/m3NR1 100 LAB DAOrig0.93 mol/m3Origmol/m3SL9 wkGrand EucalyptusBCMNACO NAT(Eucalyptus grandis)BCM36. d TNOAEL: 0.93 mol/m3NR1 100 LAB DAOrig0.93 mol/m3Origmol/m3SL9 wkRed River GumBCMNACO NAT(Eucalyptus camaldulensis)BCM36. d TNOAEL: 0.93 mol/m3NR1 100 LAB DAOrig0.93 mol/m3Origmol/m3SL9 wkMonday, June 15, 2015Page 23 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #82075Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ruiz JM;Rivero RM;Romero LTitle:Preliminary Studies on the Involvement of Biosynthesis of Cysteine and GlutathioneConcentration in the Resistance to B Toxicity in Sunflower PlantsYear:2003Source:Plant Sci. 165(4): 811-817Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Common Annual SunflowerACCRSDE UKS(Helianthus annuus)ACC15. d TLOAEL: 500 uMNR1 100 LAB DA 5.8Orig500 uMOriguM1 moCommon Annual SunflowerBCMGLTH UKS(Helianthus annuus)BCM15. d TLOAEL: 500 uMNR1 100 LAB DA 5.8Orig500 uMOriguM1 moCommon Annual SunflowerBCMGTST UKS(Helianthus annuus)ENZ15. d TLOAEL: 500 uMNR1 100 LAB DA 5.8Orig500 uMOriguM1 moRef #82595Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Chatterjee C;Sinha P;Dube BKTitle:"Biochemical Changes, Yield, and Quality of Gram Under Boron Stress"Year:2005Source:Commun. Soil Sci. Plant Anal. 36(13-14): 1763-1771Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Chick PeaACCRSDE NAT(Cicer arietinum)ACC94. d TLOAEL: 1.65 ppmNR1 100 LAB WAOrig1.65 mg/LOrigmg/LSDChick PeaBCMACPH NAT(Cicer arietinum)ENZ79. d TLOAEL: 1.65 ppmNR1 100 LAB WAOrig1.65 mg/LOrigmg/LSDChick PeaGROWGHT NAT(Cicer arietinum)MPH94. d TLOAEL: 1.65 ppmNR1 100 LAB WAOrig1.65 mg/LOrigmg/LSDChick PeaPOPBMAS NAT(Cicer arietinum)POP94. d TLOAEL: 1.65 ppmNR1 100 LAB WAOrig1.65 mg/LOrigmg/LSDMonday, June 15, 2015Page 24 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #83668Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gunes A;Alpaslan M;Cikili Y;Ozcan HTitle:Effect of Zinc on the Alleviation of Boron Toxicity in TomatoYear:1999Source:J. Plant Nutr. 22(7): 1061-1068Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.TomatoACCRSDE NAT(Solanum lycopersicumlycopersicum)ACC35. d TNOAEL: 5 ppmLOAEL: 10 ppm3 100 FIELDA ENOrig5 mg/kg soilOrig10 mg/kg soilSL3 wkTomatoBCMZNCO NAT(Solanum lycopersicumlycopersicum)BCM35. d TNOAEL: 5 ppmLOAEL: 10 ppm3 100 FIELDA ENOrig5 mg/kg soilOrig10 mg/kg soilSL3 wkRef #105975Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:De BK;Sengupta PCTitle:Chemical Control of Common Scab of PotatoYear:1993Source:J. Indian Potato Assoc. 20(3/4): 273-274Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.PotatoGROEMRG NAT(Solanum tuberosum)DVP~91.32 d TNOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%TUPotatoPHYIFCT NAT(Solanum tuberosum)IMM~91.32 d TNOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%TURef #105979Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Jalali I;Mehta NTitle:Evaluation of Pre-planting and Post-harvest Seed Tuber Treatment for the Control of BlackScurf of PotatoYear:1994Source:J. Indian Potato Assoc. 21(3-4): 226-230Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 25 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105979Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Jalali I;Mehta NTitle:Evaluation of Pre-planting and Post-harvest Seed Tuber Treatment for the Control of BlackScurf of PotatoYear:1994Source:J. Indian Potato Assoc. 21(3-4): 226-230Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.PotatoPOPBMAS NAT(Solanum tuberosum)POPhv TNOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%PotatoPOPBMAS NAT(Solanum tuberosum)POPhv TNOAEL: 5 %NR3 100 FIELDN SPOrig5 %Orig%PotatoPOPBMAS NAT(Solanum tuberosum)POPhv TNOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%PotatoPOPBMAS NAT(Solanum tuberosum)POPhv TNOAEL: 5 %NR3 100 FIELDN SPOrig5 %Orig%Ref #106674Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rajput CBS;Singh BP;Mishra HPTitle:Effects of Foliar Application of Boron on MangoYear:1976Source:Sci. Hortic. 5(4): 311-313Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.MangoBCMACID NAT(Mangifera indica)BCM91.32 d TNOAEL: 0.2 %LOAEL: 0.4 %4 100 FIELDN SPOrig0.2 %Orig0 %MangoGROLGTH NAT(Mangifera indica)MPH91.32 d TLOAEL: 0.6 %NR4 100 FIELDN SPOrig0.6 %Orig%MangoGROLGTH NAT(Mangifera indica)MPH91.32 d TLOAEL: 0.2 %NR4 100 FIELDN SPOrig0.2 %Orig%MangoGROLGTH NAT(Mangifera indica)MPH91.32 d TNOAEL: 0.4 %NR4 100 FIELDN SPOrig0.4 %Orig%Monday, June 15, 2015Page 26 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106674Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rajput CBS;Singh BP;Mishra HPTitle:Effects of Foliar Application of Boron on MangoYear:1976Source:Sci. Hortic. 5(4): 311-313Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.MangoGROWDTH NAT(Mangifera indica)MPH91.32 d TLOAEL: 0.2 %NR4 100 FIELDN SPOrig0.2 %Orig%MangoGROWGHT NAT(Mangifera indica)MPH91.32 d TLOAEL: 0.2 %NR4 100 FIELDN SPOrig0.2 %Orig%MangoPHYABSC NAT(Mangifera indica)PHY91.32 d TLOAEL: 0.2 %NR4 100 FIELDN SPOrig0.2 %Orig%MangoREPFRUT NAT(Mangifera indica)REP91.32 d TNOAEL: 0.8 %NR4 100 FIELDN SPOrig0.8 %Orig%Ref #106675Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Mason GF;Guttridge CGTitle:"The Role of Calcium, Boron and Some Divalent Ions in Leaf Tipburn of Strawberry"Year:1974Source:Sci. Hortic. 2(3): 299-308Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Hybrid StrawberryACCRSDE NAT(Fragaria x ananassa)ACC~121.76 d TNOAEL: 0.1 ppmLOAEL: 0.5 ppm6 100 FIELDA DWOrig0.1 ppmOrig0 ppmRef #107383Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ghanati F;Morita A;Yokota HTitle:Deposition of Suberin in Roots of Soybean Induced by Excess BoronYear:2005Source:Plant Sci. 168(2): 397-405Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 27 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #107383Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ghanati F;Morita A;Yokota HTitle:Deposition of Suberin in Roots of Soybean Induced by Excess BoronYear:2005Source:Plant Sci. 168(2): 397-405Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SoybeanBCMPHLL AQU(Glycine max)ENZ6. d TLOAEL: 5 mMNR1 100 LAB HPOrig5 mMOrigmMSoybeanBCMPNYL AQU(Glycine max)BCM6. d TLOAEL: 5 mMNR1 100 LAB HPOrig5 mMOrigmMRef #107423Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Watters BS;Sturgeon SRTitle:The Toxicity of Some Foliar Nutrients and Fungicides to Apple Pollen cv. Golden DeliciousYear:1990Source:Tests Agrochem. Cultiv. 11: 70-71Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.AppleREPGERM AGR(Malus sp.)REPgm TNOAEL: 612 ppmNR1 100 LAB SPOrig612 AI mg/LOrigAI mg/LRef #108828Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rozema J;De Bruin J;Broekman RATitle:Effect of Boron on the Growth and Mineral Economy of Some Halophytes and Non-HalophytesYear:1992Source:New Phytol. 121(2): 249-256Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BeanACCRSDE HYP(Phaseolus vulgaris)ACC28. d TNOAEL: 0.35 mol/m3LOAEL: 1.75 mol/m3 1 100 LAB HP 6.5Orig0.35 mol/m3Orig2 mol/m3Bean BCM KCON HYP(Phaseolus vulgaris)BCM 28. d TNOAEL: 0.025 mol/m3LOAEL: 0.35 mol/m3 1 100 LAB HP 6.5Orig0.025 mol/m3Orig0 mol/m3Monday, June 15, 2015Page 28 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #108828Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rozema J;De Bruin J;Broekman RATitle:Effect of Boron on the Growth and Mineral Economy of Some Halophytes and Non-HalophytesYear:1992Source:New Phytol. 121(2): 249-256Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Common FoxgloveACCRSDE HYP(Digitalis purpurea)ACC28. d TLOAEL: 0.025 mol/m3NR1 100 LAB HP 6.5Orig0.025 mol/m3Origmol/m3Common FoxgloveBCMKCON HYP(Digitalis purpurea)BCM28. d TNOAEL: 0.025 mol/m3LOAEL: 0.35 mol/m3 1 100 LAB HP 6.5Orig0.025 mol/m3Orig0 mol/m3False Mayweed ACC RSDE HYP(Tripleurospermum maritima)ACC 28. d TLOAEL: 0.025 mol/m3NR1 100 LAB HP 6.5Orig0.025 mol/m3Origmol/m3False MayweedBCMKCON HYP(Tripleurospermum maritima)BCM28. d TNOAEL: 0.35 mol/m3LOAEL: 1.75 mol/m3 1 100 LAB HP 6.5Orig0.35 mol/m3Orig2 mol/m3Goose Tongue ACC RSDE HYP(Plantago maritima)ACC 28. d TLOAEL: 0.025 mol/m3NR1 100 LAB HP 6.5Orig0.025 mol/m3Origmol/m3Goose TongueBCMKCON HYP(Plantago maritima)BCM28. d TLOAEL: 0.025 mol/m3NR1 100 LAB HP 6.5Orig0.025 mol/m3Origmol/m3Grassleaf OracheACCRSDE HYP(Atriplex littoralis)ACC28. d TNOAEL: 0.025 mol/m3LOAEL: 0.35 mol/m3 1 100 LAB HP 6.5Orig0.025 mol/m3Orig0 mol/m3Grassleaf Orache BCM KCON HYP(Atriplex littoralis)BCM 28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Media SandspurryACCRSDE HYP(Spergularia maritima)ACC28. d TLOAEL: 0.025 mol/m3NR1 100 LAB HP 6.5Orig0.025 mol/m3Origmol/m3Media SandspurryBCMKCON HYP(Spergularia maritima)BCM28. d TNOAEL: 1.75 mol/m3NR1 100 LAB HP 6.5Orig1.75 mol/m3Origmol/m3Thrift SeapinkBCMKCON HYP(Armeria maritima)BCM28. d TNOAEL: 0.35 mol/m3LOAEL: 1.75 mol/m3 1 100 LAB HP 6.5Orig0.35 mol/m3Orig2 mol/m3Monday, June 15, 2015Page 29 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #108828Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rozema J;De Bruin J;Broekman RATitle:Effect of Boron on the Growth and Mineral Economy of Some Halophytes and Non-HalophytesYear:1992Source:New Phytol. 121(2): 249-256Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Woodland FigwortACCRSDE HYP(Scrophularia nodosa)ACC28. d TLOAEL: 0.025 mol/m3NR1 100 LAB HP 6.5Orig0.025 mol/m3Origmol/m3Woodland FigwortBCMKCON HYP(Scrophularia nodosa)BCM28. d TNOAEL: 0.35 mol/m3LOAEL: 1.75 mol/m3 1 100 LAB HP 6.5Orig0.35 mol/m3Orig2 mol/m3Woodland Ragwort ACC RSDE HYP(Senecio sylvaticus)ACC 28. d TLOAEL: 0.025 mol/m3NR1 100 LAB HP 6.5Orig0.025 mol/m3Origmol/m3Woodland RagwortBCMKCON HYP(Senecio sylvaticus)BCM28. d TNOAEL: 0.025 mol/m3LOAEL: 0.35 mol/m3 1 100 LAB HP 6.5Orig0.025 mol/m3Orig0 mol/m3Ref #115189Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gunes A;Soylemezoglu G;Inal A;Bagci EG;Coban S;Sahin OTitle:Antioxidant and Stomatal Responses of Grapevine (Vitis vinifera L.) to Boron ToxicityYear:2006Source:Sci. Hortic. 110(3): 279-284Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.GrapeACCRSDE NAT(Vitis sp.)ACC73. d TLOAEL: 10 ppmNR1 100 LAB DA 7.91*Orig10 mg/kgOrigmg/kgGrapeBCMH2O2 NAT(Vitis sp.)BCM73. d TLOAEL: 10 ppmNR1 100 LAB DA 7.91*Orig10 mg/kgOrigmg/kgGrapeBCMLPXG NAT(Vitis sp.)ENZ73. d TLOAEL: 10 ppmNR1 100 LAB DA 7.91*Orig10 mg/kgOrigmg/kgGrapePHYSMRE NAT(Vitis sp.)PHYd TNOAEL: 10 ppmLOAEL: 20 ppm1 100 LAB DA 7.91*Orig10 mg/kgOrig20 mg/kgMonday, June 15, 2015Page 30 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #115279Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Yu CL;Luo SG;Peng XL;Liu YYTitle:"Effects of Boron, Zinc, and Iron on the Gentiopicroside Content and Yield of Gentian"Year:2006Source:Pedosphere 16(2): 210-214Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.GentianBCMGTPC NAT(Gentiana manshurica)BCMhv TLOAEL: 4.5 gNR1 100 FIELDN SP 8.2*Orig4.5 gOrigg2 yrRef #116125Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Bhatt L;Srivastava BKTitle:Effect of Foliar Application of Micronutrients on Physical Characteristics and Quality Attributesof Tomato (Lycopersicon esculentum) FruitsYear:2005Source:Indian J. Agric. Sci. 75(9): 591-592Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.TomatoBCMACID NAT(Solanum lycopersicumlycopersicum)BCMhv TNOAEL: 100 ppmNR1 100 FIELDN FSOrig100 ppmOrigppmTomatoGROWGHT NAT(Solanum lycopersicumlycopersicum)MPHhv TNOAEL: 100 ppmNR1 100 FIELDN FSOrig100 ppmOrigppmRef #119264Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ardic M;Sekmen AH;Tokur S;Ozdemir F;Turkan ITitle:Antioxidant Responses of Chickpea Plants Subjected to Boron ToxicityYear:2009Source:Plant Biol. 11(3): 328-338Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Chick PeaBCMMNSD HYP(Cicer arietinum)ENZ7. d TLOAEL: 1.6 mMNR1 100 LAB HPOrig1.6 mMOrigmMSL21 dMonday, June 15, 2015Page 31 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #119264Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ardic M;Sekmen AH;Tokur S;Ozdemir F;Turkan ITitle:Antioxidant Responses of Chickpea Plants Subjected to Boron ToxicityYear:2009Source:Plant Biol. 11(3): 328-338Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Chick PeaBCMMNSD HYP(Cicer arietinum)ENZ7. d TLOAEL: 1.6 mMNR1 100 LAB HPOrig1.6 mMOrigmMSL21 dChick PeaPHYPSII HYP(Cicer arietinum)PHY7. d TNOAEL: 6.4 mMNR1 100 LAB HPOrig6.4 mMOrigmMSL21 dChick PeaPHYPSII HYP(Cicer arietinum)PHY7. d TNOAEL: 1.6 mMLOAEL: 6.4 mM1 100 LAB HPOrig1.6 mMOrig6 mMSL21 dRef #151386Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aydin M;Cakir FTitle:Research on Weed Species for Phytoremediation of Boron Polluted SoilYear:2009Source:Afr. J. Biotechnol. 8(18): 4514-4518Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Green AmaranthACCRSDE NAT(Amaranthus retroflexus)ACC35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDGreen AmaranthACCRSDE NAT(Amaranthus retroflexus)ACC35. d TNOAEL: 20 ppmLOAEL: 30 ppm1 100 LAB DA 7.87*Orig20 mg/kg soilOrig30 mg/kg soilSDGreen AmaranthPOPWGHT NAT(Amaranthus retroflexus)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDGreen AmaranthPOPWGHT NAT(Amaranthus retroflexus)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDLamb's-QuartersACCRSDE NAT(Chenopodium album)ACC35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDMonday, June 15, 2015Page 32 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #151386Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aydin M;Cakir FTitle:Research on Weed Species for Phytoremediation of Boron Polluted SoilYear:2009Source:Afr. J. Biotechnol. 8(18): 4514-4518Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Lamb's-QuartersACCRSDE NAT(Chenopodium album)ACC35. d TNOAEL: 10 ppmLOAEL: 20 ppm1 100 LAB DA 7.87*Orig10 mg/kg soilOrig20 mg/kg soilSDLamb's-QuartersPOPWGHT NAT(Chenopodium album)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDLamb's-QuartersPOPWGHT NAT(Chenopodium album)POP35. d TLOAEL: 10 ppmNR1 100 LAB DA 7.87*Orig10 mg/kg soilOrigmg/kg soilSDRef #151401Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cervilla LM;Blasco B;Rios JJ;Romero L;Ruiz JMTitle:Oxidative Stress and Antioxidants in Tomato (Solanum lycopersicum) Plants Subjected toBoron ToxicityYear:2007Source:Ann. Bot. 100(4): 747-756Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Garden TomatoACCRSDE ART(Solanum lycopersicum)ACC14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppGarden TomatoACCRSDE ART(Solanum lycopersicum)ACC14. d TNOAEL: 0.5 mMLOAEL: 2 mM1 100 LAB WA 5.8*Orig0.5 mMOrig2 mM42 dppGarden TomatoBCMH2O2 ART(Solanum lycopersicum)BCM14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppGarden TomatoBCMH2O2 ART(Solanum lycopersicum)BCM14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppGarden TomatoBCMMDHA ART(Solanum lycopersicum)ENZ14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppMonday, June 15, 2015Page 33 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #151401Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cervilla LM;Blasco B;Rios JJ;Romero L;Ruiz JMTitle:Oxidative Stress and Antioxidants in Tomato (Solanum lycopersicum) Plants Subjected toBoron ToxicityYear:2007Source:Ann. Bot. 100(4): 747-756Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Garden TomatoBCMMDHA ART(Solanum lycopersicum)ENZ14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppRef #152311Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cervilla LM;Blasco B;Rios JJ;Rosales MA;Rubio-Wilhelmi MM;Sanchez-Rodriguez E;RomeroL;Ruiz JMTitle:Response of Nitrogen Metabolism to Boron Toxicity in Tomato PlantsYear:2008Source:Plant Biol. 11(5): 671-677Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Garden TomatoBCMNCON ART(Solanum lycopersicum)BCM14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppGarden TomatoBCMNH4I ART(Solanum lycopersicum)BCM14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppGarden TomatoBCMNRDT ART(Solanum lycopersicum)ENZ14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppGarden TomatoBCMNRDT ART(Solanum lycopersicum)ENZ14. d TLOAEL: 0.5 mMNR1 100 LAB WA 5.8*Orig0.5 mMOrigmM42 dppMonday, June 15, 2015Page 34 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #159071Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Chernobrovkina NP;Titov AF;Robonen EV;Morozov AKTitle:Effect of Boric Acid on the Ability of Plants to Accumulate Heavy MetalsYear:2012Source:Russ. J. Ecol. 43(1): 29-32Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Common DandelionPHYPBUP NAT(Taraxacum officinale)PHYstg TLOAEL: 0.0892 lb/acreNR1 100 FIELDN DAOrig0.1 kg/haOrigkg/haRed CloverPHYZNUP NAT(Trifolium pratense)PHYstg TNOAEL: 2.68 lb/acreNR1 100 FIELDN DAOrig3 kg/haOrigkg/haRef #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.AlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDMonday, June 15, 2015Page 35 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.AlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDAlfalfaREPGERM FLT(Medicago sativa)REP5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDMonday, June 15, 2015Page 36 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.LettuceREPGERM FLT(Lactuca sativa)REP5. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDLettuceREPGERM FLT(Lactuca sativa)REP5. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TEC10: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDMonday, June 15, 2015Page 37 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161023Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Hillis DG;Fletcher J;Solomon KR;Sibley PKTitle:Effects of Ten Antibiotics on Seed Germination and Root Elongation in Three Plant SpeciesYear:2011Source:Arch. Environ. Contam. Toxicol. 60(2): 220-232Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Wild CarrotREPGERM FLT(Daucus carota)REP7. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TEC25: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TEC50: >640 ppmNR1 100 LAB ENOrig>640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDWild CarrotREPGERM FLT(Daucus carota)REP7. d TNOAEL: 640 ppmNR1 100 LAB ENOrig640 mg/LOrigmg/LSDRef #161446Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cooper WC;Gorton BS;Olson EOTitle:Ionic Accumulation in Citrus as Influenced by Rootstock and Scion and Concentration of Saltsand Boron in the SubstrateYear:1952Source:Plant Physiol. 27: 191-203Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 38 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #161446Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cooper WC;Gorton BS;Olson EOTitle:Ionic Accumulation in Citrus as Influenced by Rootstock and Scion and Concentration of Saltsand Boron in the SubstrateYear:1952Source:Plant Physiol. 27: 191-203Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CitrusACCRSDE NAT(Citrus sp.)ACC273. d TNOAEL: 1 ppmLOAEL: 3 ppm1 100 FIELDN DA 7.1*Orig1 ppmOrig3 ppm1 yrCitrusBCMCACO NAT(Citrus sp.)BCM273. d TLOAEL: 1 ppmNR1 100 FIELDN DA 7.1*Orig1 ppmOrigppm1 yrCitrusBCMCLCO NAT(Citrus sp.)BCM273. d TNOAEL: 6 ppmNR1 100 FIELDN DA 7.1*Orig6 ppmOrigppm1 yrCitrusBCMKCON NAT(Citrus sp.)BCM273. d TNOAEL: 1 ppmLOAEL: 3 ppm1 100 FIELDN DA 7.1*Orig1 ppmOrig3 ppm1 yrCitrusBCMNACO NAT(Citrus sp.)BCM273. d TNOAEL: 6 ppmNR1 100 FIELDN DA 7.1*Orig6 ppmOrigppm1 yrRef #166349Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aquea F;Federici F;MoscosoC;Vega A;Jullian P;Haseloff J;Arce-Johnson PTitle:A Molecular Framework for the Inhibition of Arabidopsis Root Growth in Response to BoronToxicityYear:2012Source:Plant Cell Environ. 35(4): 719-734Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.RockcressCELCB1M HYP(Arabidopsis sp.)GEN0.5 d TLOAEL: 5 mMNR1 100 LAB HP 5.7*Orig5 mMOrigmMSL5 dRockcressCELDIVC HYP(Arabidopsis sp.)CEL0.5 d TLOAEL: 5 mMNR1 100 LAB HP 5.7*Orig5 mMOrigmMSL5 dMonday, June 15, 2015Page 39 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166349Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Aquea F;Federici F;MoscosoC;Vega A;Jullian P;Haseloff J;Arce-Johnson PTitle:A Molecular Framework for the Inhibition of Arabidopsis Root Growth in Response to BoronToxicityYear:2012Source:Plant Cell Environ. 35(4): 719-734Test Chemical:Boric acid (H2BO3)CAS Number:17024372Lifestage:AgeFormul.RockcressCELNCEL HYP(Arabidopsis sp.)CEL5. d TLOAEL: 5 mMNR1 100 LAB HP 5.7*Orig5 mMOrigmMSL5 dRef #166350Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Ardic M;Sekmen AH;Turkan I;Tokur S;Ozdemir FTitle:The Effects of Boron Toxicity on Root Antioxidant Systems of Two Chickpea (Cicer arietinumL.) CultivarsYear:2009Source:Plant Soil 314: 99-108Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Chick PeaACCRSDE HYP(Cicer arietinum)ACC7. d TLOAEL: 1.6 mMNR1 100 LAB HPOrig1.6 mMOrigmMSL21 dppChick PeaACCRSDE HYP(Cicer arietinum)ACC7. d TLOAEL: 1.6 mMNR1 100 LAB HPOrig1.6 mMOrigmMSL21 dppChick PeaBCMMLDH HYP(Cicer arietinum)BCM7. d TLOAEL: 1.6 mMNR1 100 LAB HPOrig1.6 mMOrigmMSL21 dppChick PeaBCMMLDH HYP(Cicer arietinum)BCM7. d TNOAEL: 6.4 mMNR1 100 LAB HPOrig6.4 mMOrigmMSL21 dppChick PeaBCMSODA HYP(Cicer arietinum)ENZ7. d TLOAEL: 1.6 mMNR1 100 LAB HPOrig1.6 mMOrigmMSL21 dppChick PeaBCMSODA HYP(Cicer arietinum)ENZ7. d TLOAEL: 1.6 mMNR1 100 LAB HPOrig1.6 mMOrigmMSL21 dppMonday, June 15, 2015Page 40 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166363Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rodriguez-Hernandez MC;Moreno DA;Carvajal M;Martinez-Ballesta MCTitle:Interactive Effects of Boron and NaCl Stress on Water and Nutrient Transport in Two BroccoliCultivarsYear:2013Source:Funct. Plant Biol. 40(7): 739-748Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BroccoliACCRSDE HYP(Brassica oleracea ssp. italica)ACC15. d TLOAEL: 1.8 ppmNR1 100 LAB HPOrig1.8 mg/LOrigmg/LSL21 dBroccoliACCRSDE HYP(Brassica oleracea ssp. italica)ACC15. d TLOAEL: 1.8 ppmNR1 100 LAB HPOrig1.8 mg/LOrigmg/LSL21 dBroccoliBCMCACO HYP(Brassica oleracea ssp. italica)BCM15. d TNOAEL: 4.3 ppmNR1 100 LAB HPOrig4.3 mg/LOrigmg/LSL21 dBroccoliBCMCACO HYP(Brassica oleracea ssp. italica)BCM15. d TNOAEL: 4.3 ppmNR1 100 LAB HPOrig4.3 mg/LOrigmg/LSL21 dBroccoliPHYPERM HYP(Brassica oleracea ssp. italica)PHY15. d TNOAEL: 4.3 ppmNR1 100 LAB HPOrig4.3 mg/LOrigmg/LSL21 dBroccoliPHYPERM HYP(Brassica oleracea ssp. italica)PHY15. d TNOAEL: 4.3 ppmNR1 100 LAB HPOrig4.3 mg/LOrigmg/LSL21 dRef #166364Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eichert T;Goldbach HETitle:Transpiration Rate Affects the Mobility of Foliar-Applied Boron in Ricinus communis L. cv.ImpalaYear:2010Source:Plant Soil 328: 165-174Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CastorbeanACCRSDE HYP(Ricinus communis)ACC0.875 d TLOAEL: 10 mMNR1 100 LAB SO 5.4Orig10 mMOrigmMSL6 dMonday, June 15, 2015Page 41 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166364Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eichert T;Goldbach HETitle:Transpiration Rate Affects the Mobility of Foliar-Applied Boron in Ricinus communis L. cv.ImpalaYear:2010Source:Plant Soil 328: 165-174Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CastorbeanACCRSDE ART(Ricinus communis)ACC1. d TLOAEL: 100 mMNR1 100 LAB SO 5.4Orig100 mMOrigmM3 to 4 wkCastorbeanACCRSDE ART(Ricinus communis)ACC1. d TLOAEL: 100 mMNR1 100 LAB SO 5.4Orig100 mMOrigmM3 to 4 wkCastorbeanACCRSDE HYP(Ricinus communis)ACC0.875 d TLOAEL: 10 mMNR1 100 LAB SO 5.4Orig10 mMOrigmMSL6 dCastorbeanACCRSDE HYP(Ricinus communis)ACC0.875 d TLOAEL: 10 mMNR1 100 LAB SO 5.4Orig10 mMOrigmMSL6 dCastorbeanACCRSDE HYP(Ricinus communis)ACC0.875 d TLOAEL: 10 mMNR1 100 LAB SO 5.4Orig10 mMOrigmMSL6 dCastorbeanACCRSDE HYP(Ricinus communis)ACC0.875 d TLOAEL: 10 mMNR1 100 LAB SO 5.4Orig10 mMOrigmMSL6 dCastorbeanACCRSDE HYP(Ricinus communis)ACC0.875 d TNOAEL: 10 mMNR1 100 LAB SO 5.4Orig10 mMOrigmMSL6 dCastorbeanACCRSDE HYP(Ricinus communis)ACC0.875 d TNOAEL: 10 mMNR1 100 LAB SO 5.4Orig10 mMOrigmMSL6 dMonday, June 15, 2015Page 42 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166379Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Will S;Eichert T;Fernandez V;Mohring J;Muller T;Romheld VTitle:Absorption and Mobility of Foliar-Applied Boron in Soybean as Affected by Plant Boron Statusand Application as a Polyol ComplexYear:2011Source:Plant Soil 344(1/2): 283-293Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SoybeanACCRSDE HYP(Glycine max)ACC21. d TLOAEL: 10 uMNR1 99.8 LAB MT 5.5*Orig10 uMOriguMSLPURef #166400Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Canesin RCFS;Buzetti S;Boliani AC;Isepon JSTitle:Leaf Spray Fertilization of Boron and Zinc on Productivity and Fruit Quality of Japanese PearTreeYear:2010Source:Acta Hortic. : 281-288Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Chinese PearACCRSDE NAT(Pyrus pyrifolia)ACC352. d TNOAEL: 0.0979 lb/acreNR1 100 FIELDN SP 4.6*Orig110 g/haOrigg/ha3 yrCChinese PearBCMACID NAT(Pyrus pyrifolia)BCM<=420. d TLOAEL: 0.0979 lb/acreNR1 100 FIELDN SP 4.6*Orig110 g/haOrigg/ha3 yrCChinese PearGROWGHT NAT(Pyrus pyrifolia)MPH<=420. d TNOAEL: 0.0979 lb/acreNR1 100 FIELDN SP 4.6*Orig110 g/haOrigg/ha3 yrCChinese PearREPFRUT NAT(Pyrus pyrifolia)REP<=420. d TNOAEL: 0.0979 lb/acreNR1 100 FIELDN SP 4.6*Orig110 g/haOrigg/ha3 yrCMonday, June 15, 2015Page 43 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166418Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Lee SH;Kim WS;Han THTitle:Effects of Post-Harvest Foliar Boron and Calcium Applications on Subsequent Season's PollenGermination and Pollen Tube Growth of Pear (Pyrus pyrifolia)Year:2009Source:Sci. Hortic. 122: 77-82Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Chinese PearACCRSDE NAT(Pyrus pyrifolia)ACC121.76 d TLOAEL: 100 ppmNR1 100 FIELDN HSOrig100 mg/LOrigmg/LChinese PearACCRSDE NAT(Pyrus pyrifolia)ACC121.76 d TLOAEL: 100 ppmNR1 100 FIELDN HSOrig100 mg/LOrigmg/LChinese PearGROWGHT NAT(Pyrus pyrifolia)MPH121.76 d TNOAEL: 1000 ppmNR1 100 FIELDN HSOrig1000 mg/LOrigmg/LChinese PearGROWGHT NAT(Pyrus pyrifolia)MPH121.76 d TNOAEL: 200 ppmLOAEL: 500 ppm1 100 FIELDN HSOrig200 mg/LOrig500 mg/LChinese PearREPGERM NAT(Pyrus pyrifolia)REP121.76 d TNOAEL: 500 ppmLOAEL: 1000 ppm1 100 FIELDN HSOrig500 mg/LOrig1000 mg/LChinese PearREPGERM AGR(Pyrus pyrifolia)REP0.083 d TNOAEL: 500 ppmNR1 100 LAB CM 6.8*Orig500 mg/LOrigmg/LGMChinese PearREPGERM NAT(Pyrus pyrifolia)REP121.76 d TNOAEL: 500 ppmLOAEL: 1000 ppm1 100 FIELDN HSOrig500 mg/LOrig1000 mg/LRef #166422Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rajak U;Rani R;Kumar R;Mandal BK;Prasad KKTitle:"Effect of Foliar Application of Urea, Borax and Zinc on Flowering, Fruiting and Fruit Quality ofAmrapali Mango"Year:2010Source:Environ. Ecol. 28(3): 1668-1671Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Monday, June 15, 2015Page 44 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166422Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rajak U;Rani R;Kumar R;Mandal BK;Prasad KKTitle:"Effect of Foliar Application of Urea, Borax and Zinc on Flowering, Fruiting and Fruit Quality ofAmrapali Mango"Year:2010Source:Environ. Ecol. 28(3): 1668-1671Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.MangoBCMASCA NAT(Mangifera sp.)BCM<=1. gs TLOAEL: 0.2 %NR1 100 FIELDN FSOrig0.2 %Orig%10 yrMangoGROPULP NAT(Mangifera sp.)MPH<=1. gs TLOAEL: 0.2 %NR1 100 FIELDN FSOrig0.2 %Orig%10 yrMangoREPTINF NAT(Mangifera sp.)REP<=1. gs TNOAEL: 0.2 %LOAEL: 0.4 %1 100 FIELDN FSOrig0.2 %Orig0 %10 yrRef #166423Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Saadati S;Moallemi N;Mortazavi SMH;Seyyednejad SMTitle:Effects of Zinc and Boron Foliar Application on Soluble Carbohydrate and Oil Contents ofThree Olive Cultivars During Fruit RipeningYear:2013Source:Sci. Hortic. 164(0): 30-34Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.OliveBCMSSUG NAT(Olea europaea)BCM145. d TNOAEL: 0.25 %NR1 100 FIELDN FS 7.6Orig0.25 %Orig%8 yrOliveBCMSSUG NAT(Olea europaea)BCM145. d TNOAEL: 0.25 %NR1 100 FIELDN FS 7.6Orig0.25 %Orig%8 yrOliveBCMSSUG NAT(Olea europaea)BCM145. d TNOAEL: 0.25 %NR1 100 FIELDN FS 7.6Orig0.25 %Orig%8 yrMonday, June 15, 2015Page 45 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166604Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Cervilla LM;Rosales MA;Rubio-Wilhelmi MM;Sanchez-Rodriguez E;Blasco B;Rios JJ;RomeroL;Ruiz JMTitle:Involvement of Lignification and Membrane Permeability in the Tomato Root Response toBoron ToxicityYear:2009Source:Plant Sci. 176(4): 545-552Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Garden TomatoACCRSDE HYP(Solanum lycopersicum)ACC16. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8*Orig0.5 mMOrigmMSL42 dGarden TomatoACCRSDE HYP(Solanum lycopersicum)ACC16. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8*Orig0.5 mMOrigmMSL42 dGarden TomatoBCMH2O2 HYP(Solanum lycopersicum)BCM8. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8*Orig0.5 mMOrigmMSL42 dGarden TomatoBCMH2O2 HYP(Solanum lycopersicum)BCM4. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8*Orig0.5 mMOrigmMSL42 dGarden TomatoBCMLPXG HYP(Solanum lycopersicum)ENZ16. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8*Orig0.5 mMOrigmMSL42 dGarden TomatoBCMPPOX HYP(Solanum lycopersicum)ENZ16. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8*Orig0.5 mMOrigmMSL42 dGarden TomatoPHYPERM HYP(Solanum lycopersicum)PHY16. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8*Orig0.5 mMOrigmMSL42 dGarden TomatoPHYPERM HYP(Solanum lycopersicum)PHY16. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8*Orig0.5 mMOrigmMSL42 dMonday, June 15, 2015Page 46 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166606Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Han S;Tang N;Jiang HX;Yang LT;Li Y;Chen LSTitle:"CO2 Assimilation, Photosystem II Photochemistry, Carbohydrate Metabolism and AntioxidantSystem of Citrus Leaves in Response to Boron Stress"Year:2009Source:Plant Sci. 176(1): 143-153Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.OrangeACCRSDE NR(Citrus maxima)ACC105. d TLOAEL: 500 uMNR1 100 LAB ENOrig500 uMOriguM10 wkOrangeBCMCHLO NR(Citrus maxima)BCM105. d TLOAEL: 500 uMNR1 100 LAB ENOrig500 uMOriguM10 wkOrangeBCMSODA NR(Citrus maxima)ENZ105. d TLOAEL: 500 uMNR1 100 LAB ENOrig500 uMOriguM10 wkOrangePHYSTOC NR(Citrus maxima)PHY105. d TLOAEL: 500 uMNR1 100 LAB ENOrig500 uMOriguM10 wkRef #166641Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Westlund A;Nohrstedt HOTitle:Effects of Stump-Treatment Substances for Root-Rot Control on Ground Vegetation and SoilProperties in a Picea abies Forest in SwedenYear:2000Source:Scand. J. For. Res. 15(5): 550-560Test Chemical:Boron sodium oxide(B8Na2O13) tetrahydrateCAS Number:12280034Lifestage:AgeFormul.American TwinflowerPOPCOVR NAT(Linnaea borealis)POP365. d TLOAEL: 10 g/m2NR1 100 FIELDN DAOrig10 g/m2Origg/m2SCommon Dog-violetPOPCOVR NAT(Viola riviniana)POP365. d TLOAEL: 0.3-6.1 g/m2NR1 100 FIELDN DAOrigOrigg/m2SErect CinquefoilPOPCOVR NAT(Potentilla erecta)POP365. d TNOAEL: 0.3-6.1 g/m2NR1 100 FIELDN DAOrigOrigg/m2SMonday, June 15, 2015Page 47 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166641Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Westlund A;Nohrstedt HOTitle:Effects of Stump-Treatment Substances for Root-Rot Control on Ground Vegetation and SoilProperties in a Picea abies Forest in SwedenYear:2000Source:Scand. J. For. Res. 15(5): 550-560Test Chemical:Boron sodium oxide(B8Na2O13) tetrahydrateCAS Number:12280034Lifestage:AgeFormul.European ThimbleweedPOPCOVR NAT(Anemone nemorosa)POP365. d TNOAEL: 0.3-6.1 g/m2NR1 100 FIELDN DAOrigOrigg/m2SWhortleberryPOPCOVR NAT(Vaccinium myrtillus)POP365. d TLOAEL: 10 g/m2NR1 100 FIELDN DAOrig10 g/m2Origg/m2SRef #166670Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rickard WH;Van Scoyoc STitle:Trace Element Uptake by Sagebrush Leaves in WashingtonYear:1984Source:Environ. Exp. Bot. 24(1): 101-104Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Big SagebushACCRSDE NAT(Artemisia tridentata)ACC730. d TNOAEL: 20000 ppmNR1 100 FIELDN WAOrig20 g/LOrigg/LASRef #166672Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Shann JR;Adriano DCTitle:The Chronic Exposure of SelectedCrop Species to Boron AerosolsYear:1988Source:Environ. Exp. Bot. 28(4): 289-300Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.ChardACCRSDE HYP(Beta vulgaris ssp. cicla)ACC35. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SPOrig1.55 ug/cm2Origug/cm2SL3 dChardACCRSDE NAT(Beta vulgaris ssp. cicla)ACC35. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SP 6.2*Orig1.55 ug/cm2Origug/cm2SL3 dMonday, June 15, 2015Page 48 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166672Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Shann JR;Adriano DCTitle:The Chronic Exposure of SelectedCrop Species to Boron AerosolsYear:1988Source:Environ. Exp. Bot. 28(4): 289-300Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CucumberACCRSDE HYP(Cucumis sativus)ACC28. d TLOAEL: 0.05 mMNR1 100 LAB DAOrig0.05 mMOrigmMSL3 dCucumberACCRSDE HYP(Cucumis sativus)ACC28. d TLOAEL: 50 mMNR1 100 LAB SPOrig50 mMOrigmMSL3 dCucumberACCRSDE HYP(Cucumis sativus)ACC28. d TLOAEL: 0.05 mMNR1 100 LAB MUOrig0.05 mMOrigmMSL3 dRadishACCRSDE NAT(Raphanus sativus)ACC35. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SP 6.2*Orig1.55 ug/cm2Origug/cm2SL3 dRadishACCRSDE HYP(Raphanus sativus)ACC35. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SPOrig1.55 ug/cm2Origug/cm2SL3 dSugar BeetACCRSDE HYP(Beta vulgaris)ACC49. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SPOrig1.55 ug/cm2Origug/cm2SL3 dSugar BeetACCRSDE NAT(Beta vulgaris)ACC49. d TLOAEL: 1.55 ug/cm2NR1 100 LAB SP 6.2*Orig1.55 ug/cm2Origug/cm2SL3 dTomatoACCRSDE HYP(Solanum lycopersicumlycopersicum)ACC28. d TLOAEL: 50 mMNR1 100 LAB SPOrig50 mMOrigmMSL3 dTomatoACCRSDE HYP(Solanum lycopersicumlycopersicum)ACC28. d TLOAEL: 0.05 mMNR1 100 LAB MUOrig0.05 mMOrigmMSL3 dTomatoACCRSDE HYP(Solanum lycopersicumlycopersicum)ACC28. d TNOAEL: 0.05 mMLOAEL: 1 mM1 100 LAB DAOrig0.05 mMOrig1 mMSL3 dMonday, June 15, 2015Page 49 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166672Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Shann JR;Adriano DCTitle:The Chronic Exposure of SelectedCrop Species to Boron AerosolsYear:1988Source:Environ. Exp. Bot. 28(4): 289-300Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.TomatoGROWGHT HYP(Solanum lycopersicumlycopersicum)MPH28. d TLOAEL: 0.05 mMNR1 100 LAB MUOrig0.05 mMOrigmMSL3 dRef #166673Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Benlloch M;Arboleda F;Barranco D;Fernandez-Escobar RTitle:Response of Young Olive Trees to Sodium and Boron Excess in Irrigation WaterYear:1991Source:Hortscience 26(7): 867-870Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.OliveMORMORT ART(Olea europaea)MOR109. d TNR-LETH: 40 ppmNR1 100 LAB WAOrig40 mg/LOrigmg/LYO3 moRef #166675Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Alpaslan M;Gunes ATitle:"Interactive Effects of Boron and Salinity Stress on the Growth, Membrane Permeability andMineral Composition of Tomato and Cucumber Plants"Year:2001Source:Plant Soil 236(1): 123-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CucumberACCRSDE NAT(Cucumis sativus)ACC42. d TLOAEL: 5 ppmNR1 100 LAB DA 7.62*Orig5 mg/kgOrigmg/kgSL3 wkCucumberBCMCLCO NAT(Cucumis sativus)BCM42. d TNOAEL: 10 ppmNR1 100 LAB DA 7.62*Orig10 mg/kgOrigmg/kgSL3 wkMonday, June 15, 2015Page 50 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166675Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Alpaslan M;Gunes ATitle:"Interactive Effects of Boron and Salinity Stress on the Growth, Membrane Permeability andMineral Composition of Tomato and Cucumber Plants"Year:2001Source:Plant Soil 236(1): 123-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.CucumberBCMKCON NAT(Cucumis sativus)BCM42. d TNOAEL: 10 ppmNR1 100 LAB DA 7.62*Orig10 mg/kgOrigmg/kgSL3 wkCucumberBCMNACO NAT(Cucumis sativus)BCM42. d TNOAEL: 10 ppmNR1 100 LAB DA 7.62*Orig10 mg/kgOrigmg/kgSL3 wkCucumberMORMORT NAT(Cucumis sativus)MOR42. d TNR-LETH: 20 ppmNR1 100 LAB DA 7.62*Orig20 mg/kgOrigmg/kgSL3 wkCucumberPHYPERM NAT(Cucumis sativus)PHY42. d TNOAEL: 10 ppmNR1 100 LAB DA 7.62*Orig10 mg/kgOrigmg/kgSL3 wkCucumberPOPBMAS NAT(Cucumis sativus)POP42. d TLOAEL: 5 ppmNR1 100 LAB DA 7.62*Orig5 mg/kgOrigmg/kgSL3 wkTomatoACCRSDE NAT(Solanum lycopersicumlycopersicum)ACC42. d TLOAEL: 5 ppmNR1 100 LAB DA 7.62*Orig5 mg/kgOrigmg/kgSL3 wkTomatoBCMCLCO NAT(Solanum lycopersicumlycopersicum)BCM42. d TNOAEL: 20 ppmNR1 100 LAB DA 7.62*Orig20 mg/kgOrigmg/kgSL3 wkTomatoBCMKCON NAT(Solanum lycopersicumlycopersicum)BCM42. d TNOAEL: 20 ppmNR1 100 LAB DA 7.62*Orig20 mg/kgOrigmg/kgSL3 wkTomatoBCMNACO NAT(Solanum lycopersicumlycopersicum)BCM42. d TNOAEL: 20 ppmNR1 100 LAB DA 7.62*Orig20 mg/kgOrigmg/kgSL3 wkMonday, June 15, 2015Page 51 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166675Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Alpaslan M;Gunes ATitle:"Interactive Effects of Boron and Salinity Stress on the Growth, Membrane Permeability andMineral Composition of Tomato and Cucumber Plants"Year:2001Source:Plant Soil 236(1): 123-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.TomatoPHYPERM NAT(Solanum lycopersicumlycopersicum)PHY42. d TNOAEL: 20 ppmNR1 100 LAB DA 7.62*Orig20 mg/kgOrigmg/kgSL3 wkTomatoPOPBMAS NAT(Solanum lycopersicumlycopersicum)POP42. d TLOAEL: 20 ppmNR1 100 LAB DA 7.62*Orig20 mg/kgOrigmg/kgSL3 wkRef #166700Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eraslan F;Inal A;Pilbeam DJ;Gunes ATitle:Interactive Effects of Salicylic Acid and Silicon on Oxidative Damage and Antioxidant Activity inSpinach (Spinacia oleracea L. cv. matador) Grown Under Boron Toxicity and SalinityYear:2008Source:Plant Growth Regul. 55(3): 207-219Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SpinachACCRSDE NAT(Spinacia oleracea)ACC69. d TLOAEL: 50 mg/kg d soilNR1 100 LAB DA 7.91*Orig50 mg/kg d soilOrigmg/kg d soil13 dppSpinachBCMCHLO NAT(Spinacia oleracea)BCM69. d TLOAEL: 50 mg/kg d soilNR1 100 LAB DA 7.91*Orig50 mg/kg d soilOrigmg/kg d soil13 dppSpinachBCMCTLS NAT(Spinacia oleracea)ENZ69. d TLOAEL: 50 mg/kg d soilNR1 100 LAB DA 7.91*Orig50 mg/kg d soilOrigmg/kg d soil13 dppSpinachPHYLDPX NAT(Spinacia oleracea)PHY69. d TNOAEL: 50 mg/kg d soiNR1 100 LAB DA 7.91*Orig50 mg/kg d soilOrigmg/kg d soil13 dppMonday, June 15, 2015Page 52 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166710Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kotur SCTitle:Standardisation of Foliar Spray of Boron for Correction of Brown Rot and for Increasing Yield ofCauliflower (Brassica oleracea convar botrytis var botrytis) in Bihar PlateauYear:1998Source:Indian J. Agric. Sci. 68(4): 218-221Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul."Broccoli, Cauliflower"ACCRSDE NAT(Brassica oleracea var. botrytis)ACChv TLOAEL: 1.34 lb/acreNR1 100 FIELDN GS 5.2*Orig1.5 kg/haOrigkg/ha"Broccoli, Cauliflower"ACCRSDE NAT(Brassica oleracea var. botrytis)ACChv TNOAEL: 0.1 %LOAEL: 0.125 %1 100 FIELDN FS 5.2*Orig0.1 %Orig0 %"Broccoli, Cauliflower"BCMCABC NAT(Brassica oleracea var. botrytis)BCMhv TLOAEL: 0.025 %NR1 100 FIELDN FS 5.2*Orig0.025 %Orig%"Broccoli, Cauliflower"BCMCABC NAT(Brassica oleracea var. botrytis)BCMhv TLOAEL: 1.34 lb/acreNR1 100 FIELDN GS 5.2*Orig1.5 kg/haOrigkg/ha"Broccoli, Cauliflower"POPBMAS NAT(Brassica oleracea var. botrytis)POPhv TNOAEL: 4 %NR1 100 FIELDN FS 5.2*Orig4 %Orig%"Broccoli, Cauliflower"POPBMAS NAT(Brassica oleracea var. botrytis)POPhv TNOAEL: 1.34 lb/acreNR1 100 FIELDN GS 5.2*Orig1.5 kg/haOrigkg/haRef #166737Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Panwar BS;Gupta SP;Kala RTitle:Responses to Boron in Pearl Millet and Chickpea in a Pot Experiment with a Non-CalcareousSoil in IndiaYear:1998Source:Acta Agron. Hung. 46(4): 335-340Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Chick PeaACCRSDE NAT(Cicer arietinum)ACCma TLOAEL: 0.1 % w/vNR1 100 LAB FS 8.3*Orig0.1 % w/vOrig% w/vTLSMonday, June 15, 2015Page 53 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166737Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Panwar BS;Gupta SP;Kala RTitle:Responses to Boron in Pearl Millet and Chickpea in a Pot Experiment with a Non-CalcareousSoil in IndiaYear:1998Source:Acta Agron. Hung. 46(4): 335-340Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Chick PeaACCRSDE NAT(Cicer arietinum)ACCma TNOAEL: 0.1 ppmLOAEL: 0.2 ppm1 100 LAB DA 8.3*Orig0.1 mg/kg soilOrig0 mg/kg soilChick PeaPOPBMAS NAT(Cicer arietinum)POPma TNOAEL: 0.4 ppmLOAEL: 0.8 ppm1 100 LAB DA 8.3*Orig0.4 mg/kg soilOrig1 mg/kg soilChick PeaPOPBMAS NAT(Cicer arietinum)POPma TNOAEL: 0.2 % w/vNR1 100 LAB FS 8.3*Orig0.2 % w/vOrig% w/vTLSRef #166739Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Bagheri A;Paull JG;Rathgen AJ;Ali SM;Moody DBTitle:Genetic Variation in the Response of Peas (Pisum sativum L.) to High Soil Concentrations ofBoronYear:1992Source:Plant Soil 146: 261-269Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.PeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDMonday, June 15, 2015Page 54 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166739Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Bagheri A;Paull JG;Rathgen AJ;Ali SM;Moody DBTitle:Genetic Variation in the Response of Peas (Pisum sativum L.) to High Soil Concentrations ofBoronYear:1992Source:Plant Soil 146: 261-269Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.PeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDPeaACCRSDE NAT(Pisum sativum)ACC45. d TLOAEL: 10 ppmNR1 100 LAB DAOrig10 mg/kgOrigmg/kgSDRef #166744Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Choi JM;Pak CH;Lee CWTitle:Micronutrient Toxicity in French MarigoldYear:1996Source:J. Plant Nutr. 19(6): 901-916Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.French MarigoldREPINFL ART(Tagetes patula)REP35. d TNOAEL: 0.5 mMLOAEL: 1 mM1 100 LAB WA 6.8 to7.3Orig0.5 mMOrig1 mMSLMonday, June 15, 2015Page 55 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166746Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Coetzer LA;Robbertse PJ;Stoffberg E;Holtzhausen CS;Barnard ROTitle:The Effect of Boron on Reproduction in Tomato (Lycopersicon esculentum) and Bean(Phaseolus vulgaris)Year:1990Source:S. Afr. J. Plant Soil 7(4): 212-217Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BeanREPSEED CUL(Phaseolus vulgaris)REPhv TNOAEL: 2 ppmNR1 100 LAB CMOrig2 mg/dm3Origmg/dm3SLRef #166751Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Swietlik DTitle:Interaction Between Zinc Deficiency and Boron Toxicity on Growth and Mineral Nutrition ofSour Orange SeedlingsYear:1995Source:J. Plant Nutr. 18(6): 1191-1207Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Sour OrangeACCRSDE CUL(Citrus aurantium)ACC90. d TLOAEL: 200 uMNR1 100 LAB HP 6.0*Orig200 uMOriguMSL~7.5 moSour OrangeBCMZNCO CUL(Citrus aurantium)BCM90. d TNOAEL: 200 uMNR1 100 LAB HP 6.0*Orig200 uMOriguMSL~7.5 moSour OrangeBCMZNCO CUL(Citrus aurantium)BCM90. d TNOAEL: 200 uMNR1 100 LAB HP 6.0*Orig200 uMOriguMSL~7.5 moRef #166762Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Poulain D;Al Mohammad HTitle:Effects of Boron Deficiency and Toxicity on Faba Bean (Vicia faba L.)Year:1995Source:Eur. J. Agron. 4(1): 127-134Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 56 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166762Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Poulain D;Al Mohammad HTitle:Effects of Boron Deficiency and Toxicity on Faba Bean (Vicia faba L.)Year:1995Source:Eur. J. Agron. 4(1): 127-134Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.BroadbeanPOPBMAS ART(Vicia faba)POP118. d TNOAEL: 8 ppmLOAEL: 32 ppm2 100 LAB WAOrig8 mg/LOrig32 mg/LSL30 dppBroadbeanREPINFL ART(Vicia faba)REP118. d TNOAEL: 8 ppmLOAEL: 32 ppm2 100 LAB WAOrig8 mg/LOrig32 mg/LSL30 dppRef #166773Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Singh R;Sharma RR;Tyagi SKTitle:"Pre-Harvest Foliar Application of Calcium and Boron Influences Physiological Disorders, FruitYield and Quality of Strawberry (Fragaria x ananassa Duch.)"Year:2007Source:Sci. Hortic. 112(2): 215-220Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Hybrid StrawberryACCRSDE NR(Fragaria x ananassa)ACC1. gs TLOAEL: 0.0107 lb/acreNR1 8 FIELDA HS 8.5Orig150 g/haOrigg/haHybrid StrawberryBCMSOSO NR(Fragaria x ananassa)BCM1. gs TNOAEL: 0.0107 lb/acreNR1 8 FIELDA HS 8.5Orig150 g/haOrigg/haHybrid StrawberryGRODFRM NR(Fragaria x ananassa)DVP1. gs TNOAEL: 0.0107 lb/acreNR1 8 FIELDA HS 8.5Orig150 g/haOrigg/haHybrid StrawberryGROFIRM NR(Fragaria x ananassa)DVP1. gs TNOAEL: 0.0107 lb/acreNR1 8 FIELDA HS 8.5Orig150 g/haOrigg/haHybrid StrawberryGROWGHT NR(Fragaria x ananassa)MPH1. gs TNOAEL: 0.0107 lb/acreNR1 8 FIELDA HS 8.5Orig150 g/haOrigg/haMonday, June 15, 2015Page 57 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166775Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gunes A;Inal A;Bagci EG;Coban S;Pilbeam DJTitle:Silicon Mediates Changes to some Physiological and Enzymatic Parameters Symptomatic forOxidative Stress in Spinach (Spinacia oleracea L.) Grown Under B ToxicityYear:2007Source:Sci. Hortic. 113(2): 113-119Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SpinachACCRSDE NAT(Spinacia oleracea)ACC87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachACCRSDE NAT(Spinacia oleracea)ACC87. d TNOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMANTO NAT(Spinacia oleracea)BCM87. d TNOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMASCP NAT(Spinacia oleracea)ENZ87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMCTLS NAT(Spinacia oleracea)ENZ87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMH2O2 NAT(Spinacia oleracea)BCM87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMLPXG NAT(Spinacia oleracea)ENZ87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMMLDH NAT(Spinacia oleracea)BCM87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMPRLN NAT(Spinacia oleracea)BCM87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMSICO NAT(Spinacia oleracea)BCM87. d TNOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDMonday, June 15, 2015Page 58 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166775Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gunes A;Inal A;Bagci EG;Coban S;Pilbeam DJTitle:Silicon Mediates Changes to some Physiological and Enzymatic Parameters Symptomatic forOxidative Stress in Spinach (Spinacia oleracea L.) Grown Under B ToxicityYear:2007Source:Sci. Hortic. 113(2): 113-119Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.SpinachBCMSICO NAT(Spinacia oleracea)BCM87. d TNOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachBCMSODA NAT(Spinacia oleracea)ENZ87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachPHYPERM NAT(Spinacia oleracea)PHY87. d TLOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDSpinachPHYSTOC NAT(Spinacia oleracea)PHY87. d TNOAEL: 30 ppmNR1 100 LAB DA 7.91*Orig30 mg/kgOrigmg/kgSDRef #166778Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eraslan F;Inal A;Gunes A;Alpaslan MTitle:"Impact of Exogenous Salicylic Acid on the Growth, Antioxidant Activity and Physiology ofCarrot Plants Subjected to Combined Salinity and Boron Toxicity"Year:2007Source:Sci. Hortic. 113(2): 120-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Wild CarrotACCRSDE NAT(Daucus carota)ACC~182.64 d TNOAEL: 25 mg/kg d soiNR1 100 LAB DA 7.91*Orig25 mg/kg d soilOrigmg/kg d soilSDWild CarrotBCMASCA NAT(Daucus carota)BCM~182.64 d TLOAEL: 25 mg/kg d soilNR1 100 LAB DA 7.91*Orig25 mg/kg d soilOrigmg/kg d soilSDWild CarrotBCMCTLS NAT(Daucus carota)ENZ~182.64 d TNOAEL: 25 mg/kg d soiNR1 100 LAB DA 7.91*Orig25 mg/kg d soilOrigmg/kg d soilSDMonday, June 15, 2015Page 59 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166778Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Eraslan F;Inal A;Gunes A;Alpaslan MTitle:"Impact of Exogenous Salicylic Acid on the Growth, Antioxidant Activity and Physiology ofCarrot Plants Subjected to Combined Salinity and Boron Toxicity"Year:2007Source:Sci. Hortic. 113(2): 120-128Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Wild CarrotPHYPERM NAT(Daucus carota)PHY~182.64 d TNOAEL: 25 mg/kg d soiNR1 100 LAB DA 7.91*Orig25 mg/kg d soilOrigmg/kg d soilSDRef #166781Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Molassiotis A;Sotiropoulos T;Tanou G;Diamantidis G;Therios ITitle:Boron-Induced Oxidative Damage and Antioxidant and Nucleolytic Responses in Shoot TipsCulture of the Apple Rootstock EM 9 (Malus domestica Borkh)Year:2006Source:Environ. Exp. Bot. 56(1): 54-62Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Paradise AppleACCRSDE CUL(Malus pumila)ACC20. d TLOAEL: 0.5 mMNR1 100 LAB DA 5.8Orig0.5 mMOrigmMParadise AppleBCMH2O2 CUL(Malus pumila)BCM20. d TNOAEL: 3 mMLOAEL: 6 mM1 100 LAB DA 5.8Orig3 mMOrig6 mMParadise AppleBCMLPXG CUL(Malus pumila)ENZ20. d TNOAEL: 3 mMLOAEL: 6 mM1 100 LAB DA 5.8Orig3 mMOrig6 mMOther terrestrial plants and fungiTaxa_Code:OTPOtherMonday, June 15, 2015Page 60 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #56206Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Halsall DMTitle:"Effects of Certain Cations on the Formation and Infectivity of Phytophthora Zoospores. 2.Effects of Copper, Boron, Cobalt, Manganese, Molybdenum, and Zinc Ions"Year:1977Source:Can. J. Microbiol. 23(8): 1002-1010Test Chemical:Boron sodium oxide (B4Na2O7)CAS Number:1330434Lifestage:AgeFormul.FungiREPSEPD CUL(Phytophthora cinnamomi)REP2. d TNOAEL: 0.00001 MNR1 100 LAB ENOrig0.00001 MOrigMFungiREPSEPD CUL(Phytophthora drechsleri)REP2. d TNOAEL: 0.00001 MNR1 100 LAB ENOrig0.00001 MOrigMRef #79623Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Martin AK;Johnson GC;McCarthy DF;Filson RBTitle:Attempts to Control Lichens on Asbestos Cement RoofingYear:1992Source:Int. Biodeterior. Biodegrad. 30(4): 261-271Test Chemical:"Boric acid (HBO2), sodium salt"CAS Number:7775191Lifestage:AgeFormul.AscomycetesPOPCOVR MIX(NR Ascomycota)POP2526.52 d TLOAEL: <5 %NR1 100 LAB DAOrig<5 %Orig%Ref #96218Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Simoglou KB;Dordas CTitle:"Effect of Foliar Applied Boron, Manganese and Zinc on Tan Spot in Winter Durum Wheat"Year:2006Source:Crop Prot. 25(7): 657-663Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungusPOPABND NR(Pyrenophora tritici-repentis)POP1. gs TLOAEL: 6.25 ppmNR1 100 FIELDN FSOrig6.25 mg/LOrigmg/LFungusPOPABND NR(Pyrenophora tritici-repentis)POP1. gs TLOAEL: 6.25 ppmNR1 100 FIELDN FSOrig6.25 mg/LOrigmg/LMonday, June 15, 2015Page 61 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #100335Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Gradis WH;Sutton TBTitle:"Effect of Insecticides, Nutrients, and Adjuvants on In Vitro Fungistatic and Fungicidal Activityof Captan and Mancozeb"Year:1981Source:Plant Dis. 65(4): 356-358Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungiGROLGTH AGR(Glomerella cingulata)MPH1. d TLOAEL: 50 ppmNR1 20.5 LAB DA 8.8Orig50 AI ug/mlOrigAI ug/ml7 to 10 dFungusGROLGTH AGR(Botryosphaeria dothidea)MPH1. d TLOAEL: 50 ppmNR1 20.5 LAB DA 8.8Orig50 AI ug/mlOrigAI ug/ml2 to 3 wkRef #105866Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Nicolotti G;Gonthier PTitle:Stump Treatment Against Heterobasidion with Phlebiopsis gigantea and Some Chemicals inPicea abies Stands in the Western AlpsYear:2005Source:For. Pathol. 35(5): 365-374Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Fungi KingdomPOPABND NON(NR Fungi)POP~730. d TLOAEL: 0.1 kg/m2NR1 100 FIELDN DAOrig0.1 kg/m2Origkg/m2FungusPOPABND NON(Heterobasidion sp.)POP~730. d TLOAEL: 0.1 kg/m2NR1 100 FIELDN DAOrig0.1 kg/m2Origkg/m2FungusPOPABND NON(Heterobasidion sp.)POP~730. d TLOAEL: 0.1 kg/m2NR1 100 FIELDN DAOrig0.1 kg/m2Origkg/m2FungusPOPABND NON(Heterobasidion sp.)POP~730. d TLOAEL: 0.1 kg/m2NR1 100 FIELDN DAOrig0.1 kg/m2Origkg/m2Monday, June 15, 2015Page 62 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105973Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Chaudhary VP;Gupta S;Singh RVTitle:Efficacy of Chemical Treatment on Storage Rot of Onion Caused by Aspergillus nigerYear:1994Source:Indian J. Mycol. Plant Pathol. 24(3): 229Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPCNTL NON(Aspergillus niger niger)POP45. d TLOAEL: 3 %NR1 100 LAB SOOrig3 %Orig%Ref #105976Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Fajola AO;Nwufo MITitle:Control of Corm Rots of Cocoyam (Colocasia esculenta) Caused by Botryodiplodia theobromaeand Sclerotium rolfsiiYear:1985Source:Fitopatol. Bras. 10(1): 49-56Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Filamentous FungiMORMORT CUL(Athelia rolfsii)MOR1. d TLD50: 14520 ppmNR11 100 LAB CMOrig14520 ai ppmOrigai ppmFungiMORMORT CUL(Lasiodiplodia theobromae)MOR1. d TLD50: 6863 ppmNR11 100 LAB CMOrig6863 ai ppmOrigai ppmRef #105979Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Jalali I;Mehta NTitle:Evaluation of Pre-planting and Post-harvest Seed Tuber Treatment for the Control of BlackScurf of PotatoYear:1994Source:J. Indian Potato Assoc. 21(3-4): 226-230Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPCNTL NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR3 100 FIELDN SPOrig3 %Orig%Monday, June 15, 2015Page 63 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105979Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Jalali I;Mehta NTitle:Evaluation of Pre-planting and Post-harvest Seed Tuber Treatment for the Control of BlackScurf of PotatoYear:1994Source:J. Indian Potato Assoc. 21(3-4): 226-230Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPCNTL NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR3 100 FIELDN SPOrig3 %Orig%FungiPOPCNTL NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN ENOrig3 %Orig%FungiPOPCNTL NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN ENOrig3 %Orig%FungiREPGERM NAT(Thanatephorus cucumeris)REPhv TNOAEL: 3 %NR1 100 FIELDN ENOrig3 %Orig%FungiREPGERM NAT(Thanatephorus cucumeris)REPhv TNOAEL: 3 %NR1 100 FIELDN ENOrig3 %Orig%FungiREPGERM NAT(Thanatephorus cucumeris)REPhv TNOAEL: 5 %NR3 100 FIELDN SPOrig5 %Orig%FungiREPGERM NAT(Thanatephorus cucumeris)REPhv TNOAEL: 5 %NR3 100 FIELDN SPOrig5 %Orig%Ref #105980Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Jose VT;Rajalakshmy VK;Jayarathnam K;Nehru CRTitle:Chemical Mixtures for Rubber Wood Treatment by Diffusion ProcessYear:1995Source:Indian J. Nat. Rubber Res. 8(1): 25-30Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungiPOPCNTL NON(Aspergillus sp.)POP1095. d TLOAEL: 7.5 %NR1 100 FIELDN ENOrig7.5 %Orig%Monday, June 15, 2015Page 64 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105980Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Jose VT;Rajalakshmy VK;Jayarathnam K;Nehru CRTitle:Chemical Mixtures for Rubber Wood Treatment by Diffusion ProcessYear:1995Source:Indian J. Nat. Rubber Res. 8(1): 25-30Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungiPOPCNTL NON(Fusarium sp.)POP1095. d TNOAEL: 7.5 %NR1 100 FIELDN ENOrig7.5 %Orig%FungiPOPCNTL NON(Lasiodiplodia theobromae)POP1095. d TNOAEL: 7.5 %NR1 100 FIELDN ENOrig7.5 %Orig%Ref #105981Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Khanna RN;Sharma JTitle:Effect of Boric Acid Treatment on Seed and Soil Borne Rhizoctonia solani Inocula andRhizosphere MicrofloraYear:1996Source:J. Indian Potato Assoc. 23(1-2): 1-7Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR3 100 FIELDN FUOrig3 %Orig%FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR3 100 FIELDN FUOrig3 %Orig%Monday, June 15, 2015Page 65 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105981Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Khanna RN;Sharma JTitle:Effect of Boric Acid Treatment on Seed and Soil Borne Rhizoctonia solani Inocula andRhizosphere MicrofloraYear:1996Source:J. Indian Potato Assoc. 23(1-2): 1-7Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN FUOrig3 %Orig%FungiPOPABND NAT(Thanatephorus cucumeris)POPhv TLOAEL: 3 %NR1 100 FIELDN SOOrig3 %Orig%Ref #105985Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Singh BP;Saxena SK;Nagaich BBTitle:Chemical Control of Dry Rot of Potatoes Caused by Fusarium spp.Year:1989Source:Indian J. Plant Prot. 17(1): 91-95Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPABND NON(Fusarium oxysporum)POP30. d TLOAEL: 4 %NR1 100 LAB ENOrig4 %Orig%FungiPOPABND NON(Fusarium oxysporum)POP30. d TLOAEL: 4 %NR1 100 LAB ENOrig4 %Orig%FungiPOPABND NON(Fusarium oxysporum)POP30. d TLOAEL: 4 %NR1 100 LAB ENOrig4 %Orig%FungiPOPABND NON(Fusarium oxysporum)POP30. d TLOAEL: 4 %NR1 100 LAB ENOrig4 %Orig%Monday, June 15, 2015Page 66 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #105988Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Mishra D;Rath GCTitle:Control of Fusarium Rot of EggplantYear:1986Source:Indian J. Agric. Sci. 56(8): 612-616Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPABND MIX(Gibberella moniliformis)POP5. d TLOAEL: 2 %NR1 100 LAB SOOrig2 %Orig%FungiPOPABND MIX(Nectria haematococca)POP5. d TLOAEL: 2 %NR1 100 LAB SOOrig2 %Orig%FungiPOPABND MIX(Gibberella moniliformis)POP5. d TLOAEL: 2 %NR1 100 LAB ENOrig2 %Orig%FungiPOPABND MIX(Nectria haematococca)POP5. d TLOAEL: 2 %NR1 100 LAB ENOrig2 %Orig%FungiPOPABND MIX(Fusarium oxysporum)POP5. d TLOAEL: 2 %NR1 100 LAB SOOrig2 %Orig%FungiPOPABND MIX(Fusarium oxysporum)POP5. d TLOAEL: 2 %NR1 100 LAB ENOrig2 %Orig%FungusPOPABND MIX(Gibberella intricans)POP5. d TLOAEL: 2 %NR1 100 LAB ENOrig2 %Orig%FungusPOPABND MIX(Gibberella intricans)POP5. d TLOAEL: 2 %NR1 100 LAB SOOrig2 %Orig%Ref #106843Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Amadioha ACTitle:Control of Storage Rot of Potato Caused by Rhizopus oryzaeYear:1996Source:Int. J. Pest Manag. 42(4): 311-314Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.Monday, June 15, 2015Page 67 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #106843Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Amadioha ACTitle:Control of Storage Rot of Potato Caused by Rhizopus oryzaeYear:1996Source:Int. J. Pest Manag. 42(4): 311-314Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungusREPGERM AGR(Rhizopus oryzae)REP0.25 d TLD50: 7951 ppmNR3 100 LAB DAOrig7951 ai ppmOrigai ppmSRRef #150120Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Pisani T;Munzi S;Paoli L;Backor M;Loppi STitle:Physiological Effects of a Geothermal Element: Boron Excess in the Epiphytic Lichen Xanthoriaparietina (L.) TH. FR.Year:2009Source:Chemosphere 76(7): 921-926Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Maritime Sunburst LichenBCMCHLA HYP(Xanthoria parietina)BCM1. d TNOAEL: 100 ppmNR1 100 LAB HPOrig100 ppmOrigppmMaritime Sunburst LichenBCMH2O2 HYP(Xanthoria parietina)BCM1. d TNOAEL: 100 ppmNR1 100 LAB HPOrig100 ppmOrigppmMaritime Sunburst LichenBCMPRCO HYP(Xanthoria parietina)BCM1. d TNOAEL: 100 ppmNR1 100 LAB HPOrig100 ppmOrigppmMaritime Sunburst LichenBCMTBAR HYP(Xanthoria parietina)BCM1. d TNOAEL: 1 ppmLOAEL: 10 ppm1 100 LAB HPOrig1 ppmOrig10 ppmMaritime Sunburst LichenPHYPSYN HYP(Xanthoria parietina)PHY1. d TNOAEL: 100 ppmNR1 100 LAB HPOrig100 ppmOrigppmMaritime Sunburst LichenREPVIAB HYP(Xanthoria parietina)REP1. d TNOAEL: 1 ppmLOAEL: 10 ppm1 100 LAB HPOrig1 ppmOrig10 ppmMonday, June 15, 2015Page 68 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166346Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kartal SN;Ayrilmis N;Imamura YTitle:Decay and Termite Resistance of Plywood Treated with Various Fire RetardantsYear:2007Source:Build. Environ. 42(3): 1207-1211Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungusPOPABND LIT(Fomitopsis palustris)POP84. d TLOAEL: 3 %NR1 99.9 LAB ENOrig3 %Orig%PUFungusPOPABND LIT(Trametes versicolor)POP84. d TLOAEL: 3 %NR1 99.9 LAB ENOrig3 %Orig%PUFungusPOPABND LIT(Trametes versicolor)POP84. d TLOAEL: 2.99 %NR1 99.8 LAB ENOrig3 %Orig%PUFungusPOPABND LIT(Fomitopsis palustris)POP84. d TLOAEL: 2.99 %NR1 99.8 LAB ENOrig3 %Orig%PURef #166373Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rolshausen PE;Urbez-Torres JR;Rooney-Latham S;Eskalen A;Smith RJ;Gubler WDTitle:Evaluation of Pruning Wound Susceptibility and Protection Against Fungi Associated withGrapevine Trunk DiseasesYear:2010Source:Am. J. Enol. Vitic. 61(1): 113-119Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPABND NR(Pleurostomophora richardsiae)POPd TLOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIFungiPOPABND NR(Phaeomoniella chlamydospora)POPd TLOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIFungiPOPABND NR(Diplodia seriata)POPd TLOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIFungiPOPABND NR(Lasiodiplodia theobromae)POPd TLOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIMonday, June 15, 2015Page 69 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166373Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Rolshausen PE;Urbez-Torres JR;Rooney-Latham S;Eskalen A;Smith RJ;Gubler WDTitle:Evaluation of Pruning Wound Susceptibility and Protection Against Fungi Associated withGrapevine Trunk DiseasesYear:2010Source:Am. J. Enol. Vitic. 61(1): 113-119Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPABND NR(Eutypa lata)POPd TLOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIFungiPOPABND NR(Phaeoacremonium aleophilum)POPd TLOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIFungiPOPABND NR(Dothiorella viticola)POPd TLOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIFungiPOPABND NR(Phaeoacremonium parasiticum)POPd TNOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIFungusPOPABND NR(Botryosphaeria dothidea)POPd TLOAEL: 50000 ppmNR1 17.5 FIELDN ENOrig50 g/LOrigg/LSRAIRef #166388Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Thomidis T;Exadaktylou ETitle:Effect of Boron on the Development of Brown Rot (Monilinia laxa) on PeachesYear:2010Source:Crop Prot. 29: 572-576Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungiPOPPGRT CUL(Monilinia laxa)POP7. d TEC50: 107.9 ppmNR1 20 LAB ENOrig107.9 ug/mlOrigug/mlSRW/WFungiPOPPGRT CUL(Monilinia laxa)POP7. d TLOAEL: 100 ppmNR1 20 LAB ENOrig100 ug/mlOrigug/mlSRW/WFungiPOPPGRT NR(Monilinia laxa)POP14. d TLOAEL: 200 ppmNR1 20 LAB ENOrig0.2 mg/mlOrigmg/mlSRW/WMonday, June 15, 2015Page 70 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166388Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Thomidis T;Exadaktylou ETitle:Effect of Boron on the Development of Brown Rot (Monilinia laxa) on PeachesYear:2010Source:Crop Prot. 29: 572-576Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungiPOPPGRT NR(Monilinia laxa)POP14. d TLOAEL: 200 ppmNR1 20 LAB ENOrig0.2 mg/mlOrigmg/mlSRW/WRef #166402Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Li Y;Yang Z;Bi Y;Zhang J;Wang DTitle:Antifungal Effect of Borates Against Fusarium sulphureum on Potato Tubers and Its PossibleMechanisms of ActionYear:2012Source:Postharvest Biol. Technol. 74: 55-61Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungiPOPABND LIT(Fusarium sulphureum)POP15. d TLOEL: 2500 ppmNR1 100 LAB SOOrig2.5 g/LOrigg/LSRFungiPOPABND LIT(Fusarium sulphureum)POP15. d TNOEL: 10000 ppmNR1 100 LAB ENOrig10 g/LOrigg/LSRFungiPOPPGRT CUL(Fusarium sulphureum)POP7. d TED50: 3200 ppmNR1 100 LAB CMOrig3.2 g/LOrigg/L2 wkFungiREPGERM CUL(Fusarium sulphureum)REP0.333 d TED50: 2400 ppmNR1 100 LAB CMOrig2.4 g/LOrigg/LSRMonday, June 15, 2015Page 71 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166419Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Lehtijarvi A;Dogmus-Lehtijarvii HT;Aday AG;Oskay FTitle:The Efficacy of Selected Biological and Chemical Control Agents Against Heterobasidionabietinum on Abies cilicicaYear:2011Source:For. Pathol. 41(6): 470-476Test Chemical:Borax (B4Na2O7.10H2O)CAS Number:1303964Lifestage:AgeFormul.FungiPOPABND NON(Heterobasidion abietinum)POP182.64 d TLOAEL: 0.01 g/cm2NR1 100 FIELDN ENOrig0.01 g/cm2Origg/cm2POFungiPOPABND NON(Heterobasidion abietinum)POP42. d TLOAEL: 0.01 g/cm2NR1 100 LAB ENOrig0.01 g/cm2Origg/cm2PORef #166620Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Pratt JE;Quill KTitle:A Trial of Disodium Octaborate Tetrahydrate for the Control of Heterobasidion annosumYear:1996Source:Eur. J. For. Pathol. 26(6): 297-305Test Chemical:Boron sodium oxide (B8Na2O13)CAS Number:12008412Lifestage:AgeFormul.FungiPOPABND NON(Heterobasidion araucariae)POP304.4 d TNOAEL: 1 % w/vLOAEL: 2 % w/v1 100 FIELDN ENOrig1 % w/vOrig2 % w/vRef #166641Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Westlund A;Nohrstedt HOTitle:Effects of Stump-Treatment Substances for Root-Rot Control on Ground Vegetation and SoilProperties in a Picea abies Forest in SwedenYear:2000Source:Scand. J. For. Res. 15(5): 550-560Test Chemical:Boron sodium oxide(B8Na2O13) tetrahydrateCAS Number:12280034Lifestage:AgeFormul.Plant KingdomPOPDVRS NAT(NR Plantae)POP365. d TLOAEL: 0.3-6.1 g/m2NR1 100 FIELDN DAOrigOrigg/m2SMonday, June 15, 2015Page 72 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166641Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Westlund A;Nohrstedt HOTitle:Effects of Stump-Treatment Substances for Root-Rot Control on Ground Vegetation and SoilProperties in a Picea abies Forest in SwedenYear:2000Source:Scand. J. For. Res. 15(5): 550-560Test Chemical:Boron sodium oxide(B8Na2O13) tetrahydrateCAS Number:12280034Lifestage:AgeFormul.Plant KingdomPOPDVRS NAT(NR Plantae)POP365. d TLOAEL: 10 g/m2NR1 100 FIELDN DAOrig10 g/m2Origg/m2SPlant KingdomPOPDVRS NAT(NR Plantae)POP365. d TLOAEL: 10 g/m2NR1 100 FIELDN DAOrig10 g/m2Origg/m2SRef #166693Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Kartal SN;Yoshimura T;Imamura YTitle:Modification of Wood with Si Compounds to Limit Boron Leaching from Treated Wood and toIncrease Termite and Decay ResistanceYear:2009Source:Int. Biodeterior. Biodegrad. 63(2): 187-190Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungusPOPABND NR(Fomitopsis palustris)POP84. d TLOAEL: 1 %NR1 100 LAB ENOrig1 %Orig%FungusPOPABND NR(Trametes versicolor)POP84. d TLOAEL: 1 %NR1 100 LAB ENOrig1 %Orig%Ref #166773Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Singh R;Sharma RR;Tyagi SKTitle:"Pre-Harvest Foliar Application of Calcium and Boron Influences Physiological Disorders, FruitYield and Quality of Strawberry (Fragaria x ananassa Duch.)"Year:2007Source:Sci. Hortic. 112(2): 215-220Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.Monday, June 15, 2015Page 73 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.Ref #166773Common NameEffect GroupMeas MediaEffectDuration TypeResults1Results2# of Levels % Purity Test Loc Exp Type pHAuthor:Singh R;Sharma RR;Tyagi SKTitle:"Pre-Harvest Foliar Application of Calcium and Boron Influences Physiological Disorders, FruitYield and Quality of Strawberry (Fragaria x ananassa Duch.)"Year:2007Source:Sci. Hortic. 112(2): 215-220Test Chemical:Boric acid (H3BO3)CAS Number:10043353Lifestage:AgeFormul.FungiPOPABND NR(Botrytis cinerea)POP1. gs TNOAEL: 0.0107 lb/acreNR1 8 FIELDA HS 8.5Orig150 g/haOrigg/haMonday, June 15, 2015Page 74 of 74Results in red indicate greater toxicity than most sensitive guideline study submitted by the registrant.