EXHIBIT 4.21

THIS WARRANT HAS BEEN, AND THE SHARES OF COMMON STOCK WHICH MAY BE RECEIVED
PURSUANT TO THE EXERCISE OF THIS WARRANT WILL BE, ACQUIRED SOLELY FOR INVESTMENT
AND NOT WITH A VIEW TO, OR FOR RESALE IN CONNECTION WITH, ANY DISTRIBUTION
THEREOF. NEITHER THIS WARRANT NOR SUCH SHARES (TOGETHER, THE "SECURITIES") HAVE
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR ANY
STATE SECURITIES LAWS. SUCH SECURITIES MAY NOT BE SOLD, OFFERED FOR SALE,
PLEDGED OR HYPOTHECATED IN THE ABSENCE OF SUCH REGISTRATION OR AN OPINION OF
COUNSEL REASONABLY SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH
DISPOSITION IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS
OF THE ACT AND OF ANY APPLICABLE STATE SECURITIES LAWS.

NO. WC-                                           ISSUED [SEE ATTACHED SCHEDULE]

                        WARRANT TO PURCHASE COMMON STOCK

                                   __________

      THIS CERTIFIES THAT, for good and valuable consideration, [SEE ATTACHED
SCHEDULE FOR NAMES OF HOLDERS] (the "HOLDER") is entitled to subscribe for and
purchase from Adventrx Pharmaceuticals, Inc., a Delaware corporation (the
"COMPANY"), [SEE ATTACHED SCHEDULE FOR NUMBER OF SHARES] fully paid and
nonassessable shares of Common Stock, par value $0.001 per share ("COMMON
STOCK"), of the Company (as adjusted pursuant to Section 3 hereof) (the "WARRANT
SHARES") at a price per share equal to One Dollar and Twenty Five Cents ($1.25)
(as adjusted pursuant to Section 3 hereof) (the "EXERCISE PRICE"), subject to
the provisions and upon the terms and conditions hereinafter set forth.

1.    METHOD OF EXERCISE; PAYMENT.

      (A) Exercise Period. The purchase rights represented by this Warrant may
be exercised by the Holder during the term of this Warrant (as set forth in
Section 9 hereof) in whole or in part, at any time after the Commencement Date,
as defined below, by the surrender of this Warrant (with the notice of exercise
form attached hereto as Exhibit A (the "NOTICE OF EXERCISE") duly executed) at
the principal office of the Company.

      (B) Cash Exercise. Upon exercise of this Warrant, the Holder shall pay the
Company an amount equal to the Exercise Price multiplied by the number of
Warrant Shares being purchased, by wire transfer or certified check payable to
the order of the Company. The person or persons in whose name(s) any
certificate(s) representing the Warrant Shares shall be issuable upon exercise
of this Warrant shall be deemed to have become the holder(s) of record of, and
shall be treated for all purposes as the record holder(s) of, the Warrant Shares
represented thereby (and such Warrant Shares shall be deemed to have been
issued) immediately prior to the close of business on the date or dates upon
which this Warrant is exercised.


                                       1
<PAGE>

      (C) Stock Certificates. In the event of any exercise of the rights
represented by this Warrant, certificates for the Warrant Shares so purchased
shall be delivered to the Holder within a reasonable time after exercise and,
unless this Warrant has been fully exercised or has expired, a new Warrant
representing the shares with respect to which this Warrant shall not have been
exercised shall also be issued to the Holder within such time.

2. STOCK FULLY PAID; RESERVATION OF SHARES. All of the Warrant Shares issuable
upon the exercise of the rights represented by this Warrant will, upon issuance
and receipt of the Exercise Price therefor, be fully paid and nonassessable, and
free from all preemptive rights, rights of first refusal or first offer, taxes,
liens and charges with respect to the issuance thereof. During the period within
which the rights represented by this Warrant may be exercised, the Company shall
at all times have authorized and reserved for issuance a sufficient number of
Warrant Shares to provide for the exercise of the rights represented by this
Warrant.

3. ADJUSTMENT OF EXERCISE PRICE AND NUMBER OF SHARES. The number and kind of
Warrant Shares purchasable upon the exercise of this Warrant and the Exercise
Price therefor shall be subject to adjustment from time to time upon the
occurrence of certain events, as follows:

      (A) Reclassification, Consolidation or Reorganization. In case of any
reclassification of the Common Stock (other than a change in par value, or as a
result of a subdivision or combination), or in case of any consolidation or
merger of the Company with or into another corporation (other than a Change of
Control, as defined below) (any of which is a "REORGANIZATION TRANSACTION"), the
Company, or such successor corporation as the case may be, shall execute a new
warrant, providing that the holder of this Warrant shall have the right to
exercise such new warrant, and procure upon such exercise and payment of the
same aggregate Exercise Price, in lieu of the Warrant Shares theretofore
issuable upon exercise of this Warrant, the kind and amount of shares of stock,
other securities, money and property as would be payable for the Warrant Shares
issuable upon exercise of this Warrant as if such Warrant Shares were
outstanding on the consummation of the Reorganization Transaction. For purposes
of this Warrant, the term "CHANGE OF CONTROL" shall mean (i) any acquisition of
the Company by means of merger, acquisition, or other form of corporate
reorganization in which outstanding shares of the Company are exchanged for
securities or other consideration issued, or caused to be issued, by the
acquiring corporation or its subsidiary or parent (other than a reincorporation
transaction or change of domicile) and pursuant to which the holders of the
outstanding voting securities of the Company immediately prior to such
consolidation, merger or other transaction fail to hold equity securities
representing a majority of the voting power of the Company or surviving entity
immediately following such consolidation, merger or other transaction (excluding
voting securities of the acquiring corporation held by such holders prior to
such transaction) or (ii) a sale of all or substantially all of the assets of
the Company.

      (B) Stock Splits, Dividends and Combinations. In the event that the
Company shall at any time subdivide the outstanding shares of Common Stock, or
shall issue a stock dividend on its outstanding shares of Common Stock, the
number of Warrant Shares issuable upon exercise of this Warrant immediately
prior to such subdivision or to the issuance of such stock dividend shall be
proportionately increased, and the Exercise Price shall be proportionately
decreased, and in the event that the Company shall at any time combine the
outstanding shares of Common Stock, the number of Warrant Shares issuable upon
exercise of this Warrant immediately prior to such combination shall be
proportionately decreased, and the Exercise Price shall be proportionately
increased, effective at the close of business on the date of such subdivision,
stock dividend or combination, as the case may be.


                                       2
<PAGE>

4. TRANSFER OF WARRANT. This Warrant may only be transferred in compliance with
federal and state securities laws and, except as provided below, may not be
transferred except with the prior written consent of the Company, which shall
not be unreasonably withheld or delayed, and any purported transfer without such
prior written consent shall be null and void; provided, however, that the
Company may withhold its consent to transfer or assignment of this Warrant to
any person or entity who is deemed to be a competitor or prospective competitor
of the Company, such determination to be made in the reasonable judgment of the
Board.

5. CONDITION TO EXERCISE OF WARRANT. Each certificate evidencing the Warrant
Shares issued upon exercise of this Warrant shall be stamped or imprinted with a
legend substantially in the following form:

      THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE BEEN ACQUIRED FOR
      INVESTMENT AND NOT WITH A VIEW TO, OR FOR RESALE IN CONNECTION WITH, ANY
      DISTRIBUTION THEREOF, AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
      ACT OF 1933, AS AMENDED (THE "ACT"), OR ANY STATE SECURITIES LAWS. SUCH
      SECURITIES MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN
      THE ABSENCE OF SUCH REGISTRATION OR AN OPINION OF COUNSEL SATISFACTORY TO
      THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED UNDER
      THE ACT OR UNLESS SOLD PURSUANT TO RULE 144 OF SUCH ACT.

6. FRACTIONAL SHARES. No fractional Warrant Shares will be issued in connection
with any exercise hereunder, but in lieu of such fractional shares the Company
shall make a cash payment therefor upon the basis of the Exercise Price then in
effect.

7. REPRESENTATIONS AND WARRANTIES BY THE HOLDER. The Holder represents and
warrants to the Company as follows:

      (A) This Warrant is being acquired for the Holder's own account, for
investment and not with a view to, or for resale in connection with, any
distribution or public offering thereof within the meaning of the Securities Act
of 1933, as amended (the "SECURITIES ACT"). Upon exercise of this Warrant, the
Holder shall, if so requested by the Company, confirm in writing, in a form
reasonably satisfactory to the Company, that the Warrant Shares issuable upon
exercise of this Warrant are being acquired for investment and not with a view
toward distribution or resale. The Holder is an "accredited investor" within the
meaning of the Securities Act.

      (B) The Holder understands that this Warrant and the Warrant Shares have
not been registered under the Securities Act by reason of their issuance in a
transaction exempt from the registration and prospectus delivery requirements of
the Securities Act pursuant to Section 4(2) thereof and that the Company's
reliance upon such exemption is predicated, in part, upon the Holder's
representations and warranties set forth in this Agreement. The Holder
understands that this Warrant and the Warrant Shares must be held by the Holder
indefinitely, and that the Holder must therefore bear the economic risk of such
investment indefinitely, unless a subsequent disposition thereof is registered
under the Securities Act or is exempted from such registration. The Holder
further understands that this Warrant and the Warrant Shares have not been
registered under the securities laws of any state.


                                       3
<PAGE>

      (C) The Holder acknowledges that it is acquiring this Warrant without
being offered or furnished any offering literature or prospectus. The Holder
understands that neither the United States Securities and Exchange Commission,
nor any governmental agency charged with the administration of the securities
laws of any state nor any other governmental agency has passed upon or reviewed
the merits or qualifications of, or recommended or approved the issuance of this
Warrant or the Warrant Shares.

      (D) The Holder understands that, except as provided in Section 10 of this
Warrant, the Company is under no obligation to register this Warrant or the
Warrant Shares.

      (E) The Holder is a bona fide resident and domiciliary (not a temporary or
transient resident) of the state indicated in the signature page hereto and the
Holder has no present intention of becoming a resident of any other state or
jurisdiction.

      (F) The Holder has such knowledge and experience in financial and business
matters that it is capable of evaluating the merits and risks of the purchase of
this Warrant and the Warrant Shares purchasable pursuant to the terms of this
Warrant and of protecting its interests in connection therewith. The Holder is
able to bear the economic risk of the purchase of the Warrant Shares pursuant to
the terms of this Warrant.

      (G) The Holder of this Warrant agrees not to undertake any short position
with respect to the underlying common stock while this warrant remains
outstanding.

8. RIGHTS OF STOCKHOLDERS. No holder of this Warrant shall be entitled, as a
Warrant holder, to vote or receive dividends or be deemed the holder of Warrant
Shares or any other securities of the Company which may at any time be issuable
on the exercise hereof for any purpose, nor shall anything contained herein be
construed to confer upon the Holder any of the rights of a stockholder of the
Company or any right to vote for the election of directors or upon any matter
submitted to stockholders at any meeting thereof, or to give or withhold consent
to any corporate action (whether upon any recapitalization, issuance of stock,
reclassification of stock, change of par value, consolidation, merger,
conveyance, or otherwise) or to receive notice of meetings, or to receive
dividends or subscription rights or otherwise with respect to the Warrant Shares
until this Warrant shall have been exercised and the Warrant Shares purchasable
upon the exercise hereof shall have become deliverable, as provided herein.


                                       4
<PAGE>

9.   TERM OF WARRANT.

      (A) This Warrant shall become exercisable on the date of issuance set
forth below (the "COMMENCEMENT DATE") and shall no longer be exercisable as of
the earlier of (i) 5:00 p.m., San Diego, California local time, on the date that
is the three-year anniversary of the Commencement Date; (ii) immediately prior
to a Change of Control and (iii) 5:00 p.m., San Diego, California local time, on
the Call Termination Date (as defined below).

      (B) Notwithstanding anything herein to the contrary, at any time after the
Commencement Date, if the closing price of one share of Common Stock quoted in
the over-the-counter market summary, the Bulletin Board Exchange, the Nasdaq
National Market or the closing price quoted on a national securities exchange,
whichever is applicable, is greater than 200% of the Exercise Price for a period
of 20 consecutive trading days, then thereafter the Company shall have the right
(the "COMPANY TERMINATION RIGHT"), exercisable at the Company's sole discretion,
to terminate this Warrant with at least 10-days' prior written notice (the
"TERMINATION NOTICE") which Termination Notice shall state the date this Warrant
shall terminate (the "CALL TERMINATION DATE"); provided, however, that the
Company may not exercise the Company Termination Right unless a registration
statement registering the Warrant Stock has been declared effective and is
effective from the date of delivery of the Termination Notice until the Call
Termination Date, provided, further, that if this Warrant is terminated pursuant
to this Section 9(b), then the Company shall use commercially reasonable efforts
to maintain the effectiveness of a registration statement registering the
Warrant Stock until the date that is 15 days after the Call Termination Date or,
if earlier, the date the Holder shall have sold all its Warrant Shares covered
by such registration statement.

10.  REGISTRATION RIGHTS.

      (A) Piggy-back Rights. If (but without any obligation to do so) the
Company proposes to register any shares of Common Stock solely for cash pursuant
to a registration statement under the Securities Act, other than a registration
solely in connection with a transaction under Rule 145 promulgated under the
Securities Act (a "PUBLIC OFFERING"), the Company shall promptly give the Holder
written notice of such Public Offering, at least 10 business days prior to the
filing of the registration statement under the Securities Act regarding such
Public Offering. Upon the written request of the Holder given within 5 business
days after delivery of such written notice by the Company, the Company shall,
subject to the provisions of Section 10(b) below, use its best efforts to cause
to be registered under the Securities Act all of the Warrant Shares that the
Holder has requested to be registered.

      (B) Underwriting. If the registration statement under which the Company
gives notice under this Section 10 is for an underwritten Public Offering, the
Company shall so advise the Holder. The right of the Holder to registration
pursuant to Section 10(a) above shall be conditioned upon the Holder's
participation in such underwriting and the inclusion of the Warrant Shares in
the underwriting to the extent provided herein. The Holder shall (together with
the Company and any other holders of Company securities distributing their
securities through such underwriting) enter into an underwriting agreement in
customary form with the underwriter or underwriters selected for underwriting by
the Company. Notwithstanding any other provision of this Section 10, if the
underwriter determines that marketing factors require a limitation of the number
of shares to be underwritten, the underwriter may exclude some or all of the
Warrant Shares from such registration and underwriting.


                                       5
<PAGE>

      (C) Furnish Information. It shall be a condition to the Company's
obligations to take any action under this Section 10 that the Holder shall
furnish to the Company such information regarding itself, the Warrant Shares,
and the intended method of disposition of such Warrant Shares as shall be
required to effect the registration of any Warrant Shares. In that connection,
the Holder shall be required to represent to the Company that all such
information which is given is both complete and accurate in all material
respects when made.

      (D) Delay of Registration. The Holder shall have no right to obtain or
seek an injunction restraining or otherwise delaying any such registration as
the result of any controversy that might arise with respect to the
interpretation or implementation of this Section 10.

      (E) Termination of Registration Rights. The Company shall have no
obligation to register Warrant Shares pursuant to this Section 10 with respect
to any request or requests made by any Holder on or after that date which is one
year after the date such Warrant Shares were deemed to be acquired for purposes
of determining the holding period of such Warrant Shares under Rule 144 of the
Act.

11.  MISCELLANEOUS.

      (A) This Warrant is being delivered in the state of California and shall
be construed and enforced in accordance with and governed by the laws of the
state of California, without giving effect to principles of conflicts of laws.

      (B) The headings in this Warrant are for purposes of reference only, and
shall not limit or otherwise affect any of the terms hereof.

      (C) The terms of this Warrant shall be binding upon and shall inure to the
benefit of any successors or assigns of the Company and of the Holder and of the
Warrant Shares issued or issuable upon the exercise hereof.

      (D) Any notice provided for or permitted under this Warrant shall be
treated as having been given (a) upon receipt, when delivered personally, (b)
upon receipt, when sent by confirmed facsimile or telecopy, (c) one day after
sending, when sent by commercial overnight courier with written verification of
receipt, or (d) three business days after deposit with the United States Postal
Service, when mailed postage prepaid by certified or registered mail, return
receipt requested, addressed (a) if to the Company, at 9948 Hibert Street, Suite
100, San Diego, CA 92131, facsimile: (858) 271-9678, Attention: Nicholas J.
Virca, or (b) if to the Holder, at such address or facsimile number as the
Holder shall have furnished to the Company in writing, or at such other place of
which the other party has been notified in accordance with the provisions of
this Section 11(d).

      (E) This Warrant constitutes the full and entire understanding and
agreement between the parties with regard to the subjects hereof.


                                       6
<PAGE>

      (F) Upon receipt of evidence reasonably satisfactory to the Company of the
loss, theft, destruction or mutilation of this Warrant and, in the case of any
such loss, theft or destruction, upon delivery of an indemnity agreement
reasonably satisfactory in form and amount to the Company or, in the case of any
such mutilation, upon surrender and cancellation of such Warrant, the Company at
the Holder's expense will execute and deliver to the holder of record, in lieu
thereof, a new Warrant of like date and tenor.

      (G) This Warrant and any provision hereof may be amended, waived or
terminated only by an instrument in writing signed by the Company and the
Holder.

      (H) Receipt of this Warrant by the Holder shall constitute acceptance of
and agreement to the foregoing terms and conditions.

                            [Signature page follows.]


                                       7
<PAGE>


      IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its duly authorized officer.

         Issued :[SEE ATTACHED SCHEDULE]

                               ADVENTRX PHARMACEUTICALS, INC.

                               By:      /s/ Nicholas J. Virca

                               Name:    Nicholas J. Virca

                               Title:   President and Chief Executive Officer

                               [SEE ATTACHED SCHEDULE]

                               By:      _______________________________________

                               Name:    _______________________________________

                               Title:   _______________________________________

                               Address:   _____________________________________

                                          _____________________________________

                               Facsimile: _____________________________________



                                       8
<PAGE>

                                    EXHIBIT A

                               NOTICE OF EXERCISE

TO:      Adventrx Pharmaceuticals, Inc.
         9948 Hibert Street, Suite 100
         San Diego, CA  92131

      The undersigned hereby elects to purchase ____________ shares of Common
Stock, par value $0.001 per share, of the Company ("COMMON STOCK") pursuant to
the terms of Section 1(b) of the Warrant to Purchase Common Stock dated
___________ 2003 (the "WARRANT"), and tenders herewith payment of the purchase
price of such shares in full.

      Please issue a certificate or certificates representing said _________
shares of Common Stock in the name of the undersigned or in such other name as
is specified below:

                           Name:      _________________________________

                           Address:   _________________________________

                                      _________________________________

      The undersigned hereby represents and warrants that the aforesaid shares
of Common Stock are being acquired for the account of the undersigned for
investment and not with a view to, or for resale, in connection with the
distribution thereof, and that the undersigned has no present intention of
distributing or reselling such shares, and that all representations and
warranties of the undersigned set forth in Section 7 of the Warrant are true and
correct as of the date hereof.

                                      ______________

                                      By:      ________________________________

                                      Name:    ________________________________

                                      Title:   ________________________________

                                      Date:    ________________________________



                                       9
<PAGE>

                           SCHEDULE OF WARRANTHOLDERS

      ADVENTRX Pharmaceuticals, Inc. issued this form of Warrant to Purchase
Common Stock to each of the persons listed below on the dates set forth below
for the purchase of up to the number of shares of Common Stock listed opposite
such person's name below.

<TABLE>
<CAPTION>

HOLDER                                                                WARRANT NO.       ISSUE DATE       SHARES
--------------------------------------------------------------------------------------------------------------------
<S>                                                                         <C>         <C>               <C>
Ball Family Trust (Edward D. Ball and Susan E. Ball, Trustees)           WC-201         10/15/2003         30,000
--------------------------------------------------------------------------------------------------------------------
Benjamin Partners Savings Plan FBO Jeffrey Benison                       WC-202         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Botka-Liu Family Revocable Trust, Dated 8/10/2000                        WC-203         10/15/2003          6,000
--------------------------------------------------------------------------------------------------------------------
David and Jennifer Brown                                                 WC-204         10/15/2003            150
--------------------------------------------------------------------------------------------------------------------
John R. and Marjorie B. Brown                                            WC-205         10/15/2003            600
--------------------------------------------------------------------------------------------------------------------
BSI-New Biomedical Frontier (Sicav)                                      WC-206         10/15/2003        150,000
--------------------------------------------------------------------------------------------------------------------
Bullbear Capital Partners, LLC                                           WC-207         10/15/2003         37,500
--------------------------------------------------------------------------------------------------------------------
Sean M. Callahan                                                         WC-208         10/15/2003          4,500
--------------------------------------------------------------------------------------------------------------------
Peter J. and Elaine Chortek, Trustees of the Peter J. and Elaine
Chortek Restarted Family Trust, Dated January 24, 1994 as Amended
and restarted                                                            WC-209         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Charles and Leslie Close                                                 WC-210         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Chicago Private Investments, Inc.                                        WC-211         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Clariden Investments, LTD.                                               WC-212         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Deborah Young, M.D. APC Employees Retirement Trust Y/A DTD 4/2/91        WC-213         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Elaine Dines                                                             WC-214         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Michael Elconin                                                          WC-215         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Jurg Fluck                                                               WC-216         10/15/2003          2,700
--------------------------------------------------------------------------------------------------------------------
Mark A. Ford                                                             WC-217         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Hans Gaverstroem                                                         WC-218         10/15/2003          6,000
--------------------------------------------------------------------------------------------------------------------
Michael M. Goldberg                                                      WC-219         10/15/2003          6,000
--------------------------------------------------------------------------------------------------------------------
Roland Hartmann                                                          WC-220         10/15/2003          6,000
--------------------------------------------------------------------------------------------------------------------
Haywood Securities Inc in Trust for Bridge Finance Ltd.                  WC-221         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Brian M. Herman                                                          WC-222         10/15/2003          7,500
--------------------------------------------------------------------------------------------------------------------
Jeff Hermanson                                                           WC-223         10/15/2003          7,500
--------------------------------------------------------------------------------------------------------------------
Kantor Family Foundation                                                 WC-224         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Dannie King                                                              WC-225         10/15/2003          7,500
--------------------------------------------------------------------------------------------------------------------
John J. Kissane                                                          WC-226         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Michael Kooper                                                           WC-227         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Jay S. and Gabrielle Kunin                                               WC-228         10/15/2003          4,500
--------------------------------------------------------------------------------------------------------------------
James Ladner                                                             WC-229         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Craig Langweiler                                                         WC-230         10/15/2003            900
--------------------------------------------------------------------------------------------------------------------
Peter Levitch                                                            WC-231         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Marital Trust GST Subject U/T/W of Leopold Salkind DTD 10/29/02,         WC-232         10/15/2003          7,500
Marilyn Salkind, Gene Salkind, Trustees

</TABLE>

                                       10
<PAGE>

<TABLE>
<CAPTION>

--------------------------------------------------------------------------------------------------------------------
<S>                                                                         <C>         <C>               <C>
David W. Penney & Sarah B. McAllister                                    WC-233         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Deborah Melnick                                                          WC-234         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Robert A. Melnick                                                        WC-235         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Paul Mezei                                                               WC-236         10/15/2003            600
--------------------------------------------------------------------------------------------------------------------
Robert J. Neborsky, M.D., Inc. Combination Retirement Trust              WC-237         10/15/2003         37,500
--------------------------------------------------------------------------------------------------------------------
William B. Newman                                                        WC-238         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Emanuel Peluso                                                           WC-239         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Lisa Rachlin                                                             WC-240         10/15/2003            150
--------------------------------------------------------------------------------------------------------------------
Mark Eugene Reaman                                                       WC-241         10/15/2003          7,500
--------------------------------------------------------------------------------------------------------------------
Joseph Reynolds                                                          WC-242         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Larry R. Rice                                                            WC-243         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Gene Salkind, M.D.                                                       WC-244         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Steven R. Salovitch                                                      WC-245         10/15/2003          3,000
--------------------------------------------------------------------------------------------------------------------
Schenk Family Trust/Carl Schenk Trustee                                  WC-246         10/15/2003          7,500
--------------------------------------------------------------------------------------------------------------------
Schroder & Co Bank AG                                                    WC-247         10/15/2003         45,000
--------------------------------------------------------------------------------------------------------------------
SDS Merchant Fund, L.P.                                                  WC-248         10/15/2003         75,000
--------------------------------------------------------------------------------------------------------------------
Eugene H. Seymour, M.D.                                                  WC-249         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Alan Sheinwald                                                           WC-250         10/15/2003          4,500
--------------------------------------------------------------------------------------------------------------------
Jay Silberman                                                            WC-251         10/15/2003         22,500
--------------------------------------------------------------------------------------------------------------------
Eric T. Singer                                                           WC-252         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
David Wiener, Revocable Trust-96                                         WC-253         10/15/2003         30,000
--------------------------------------------------------------------------------------------------------------------
Sandi Yurichuk                                                           WC-254         10/15/2003          7,500
--------------------------------------------------------------------------------------------------------------------
HSB Capital                                                              WC-255         10/15/2003          7,500
--------------------------------------------------------------------------------------------------------------------
Andrew J. Maffey                                                         WC-256         10/15/2003          7,500
--------------------------------------------------------------------------------------------------------------------
Angelika Frangou                                                         WC-258         10/15/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Richard Melnick                                                          WC-260         10/15/2003         16,000
--------------------------------------------------------------------------------------------------------------------
P Bioventures LLC                                                       WC-261         10/15/2003         21,750
--------------------------------------------------------------------------------------------------------------------
Michael Gottlieb                                                         WC-262         10/15/2003         12,500
--------------------------------------------------------------------------------------------------------------------
Robert Nathan                                                            WC-264         10/15/2003          7,525
--------------------------------------------------------------------------------------------------------------------
HC Wainwright                                                            WC-265         10/15/2003          3,225
--------------------------------------------------------------------------------------------------------------------
Brian Corday                                                             WC-266         10/15/2003          3,125
--------------------------------------------------------------------------------------------------------------------
Ernst Pernet                                                             WC-267         10/15/2003         15,450
--------------------------------------------------------------------------------------------------------------------
Christopher P. Baker                                                     WC-268         12/15/2003         75,000
--------------------------------------------------------------------------------------------------------------------
Anasazi Partners III, LLC                                                WC-269         12/15/2003         75,000
--------------------------------------------------------------------------------------------------------------------
Anasazi Partners II, LLC                                                 WC-270         12/15/2003         30,000
--------------------------------------------------------------------------------------------------------------------
Pali Capital, LLC                                                        WC-271         12/15/2003          4,462
--------------------------------------------------------------------------------------------------------------------
Mathew Balk                                                              WC-272         12/15/2003         20,081
--------------------------------------------------------------------------------------------------------------------
Burnham Hill Holdings, LLC                                               WC-273         12/15/2003         20,082
--------------------------------------------------------------------------------------------------------------------
Craig Pierson                                                            WC-274          12/4/2003         67,500
--------------------------------------------------------------------------------------------------------------------
Michael Gottlieb                                                         WC-275          12/4/2003         67,500
--------------------------------------------------------------------------------------------------------------------
Benny Daniels                                                            WC-276          12/4/2003         15,000
--------------------------------------------------------------------------------------------------------------------
Schroder & Co. Bank AG, Zurich                                           WC-277         12/15/2003        240,000
--------------------------------------------------------------------------------------------------------------------
Clariden Investments, LTD.                                               WC-278         12/15/2003          6,000
--------------------------------------------------------------------------------------------------------------------
Peter Levitch                                                            WC-279         12/15/2003          9,000
--------------------------------------------------------------------------------------------------------------------
Bridge Finance, LTD                                                      WC-280         12/29/2003         61,500
--------------------------------------------------------------------------------------------------------------------
VP Bioventures, LLC                                                      WC-281         12/29/2003          2,250
--------------------------------------------------------------------------------------------------------------------

</TABLE>

                                       11