# OAR Box 1112 Prepped by Ryan Dugan



## Document

Number: 

# 39 ) ll-C- 5
Docket Number: 

# A-83-2 2

Printed 4/16/20089:12:07AM Sheet 39of 97 P. 1P. 2


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- * > <•<* • " i PRO**- 0 UNITE D STATE S ENVIRONMENTA L PROTECTIO N AGENC Y Offic e o f Ai rQualit yPlannin g an d Standard s / Researc h Triangl e Park , Nort h Carolin a 2771 1 Februar y7 , 198 6

Dr

. Morto n Lippman n Professo r Departmen t o fEnvironmenta l Medicin e Ne wYor k Universit yMedica l Cente r 

### Tuxedo , Ne

wYork1098 7 Dea rDr

. Lippmann : Enclose d fo ryou rrevie wi s th e revise d draf t staf f pape rfo rlea d tha t i s t o b e discusse d a t th e Marc h 11-12 , 198 6 Clea n Ai rScientifi c Advisor yCommitte e (CASAC ) meeting

. T o facilitat e th e revie wprocess , I woul d lik e t o specificall ydirec t you rattentio n t o Sectio n VI I o fth e paper
. I n respons e t o th e Committee' s comments an d recommendation s las t spring , th e staf fha s substantiall y revise d th e discussio n o faveragin g time , for m an d samplin g frequency

. I n addition , th e Section' s discussio n o fhealt h effect s ha s bee n update d principall yt o includ e severa l ne wstudie s o n neurologica l effect s an d t o incorporat e th e result s o f th e probabilit yencodin g o n lead-induce d hemoglobi n an d I Q decrements

. W e hav e deferred , however , fro m full y incorporatin g th e informatio n o n hypertensio n an d statur e unti l afte r CASA C revie wo fth e addendu m t o th e criteri a document

. Finally , th e portio n o fSectio n VI I tha t discusse s approache s fo restimatin g bloo d lea d level s unde ralternativ e ai rlea d level s ha s bee n revise d t o explicitl y reflec t CASAC' s recommendatio n wit h respec t t o childre n livin g i n deteriorating , lead-base d painte d homes

. Th e summar

yan d conclusio n portio n o f Sectio n VII I ha s als o bee n revised , an d a ne

wAppendi xE ha s bee n adde d whic h examine s th e long-ter m accumulatio n o flea d i n soi l i n rura l areas
. Othe rportion s o fth e pape r hav e bee n revise d an d update d a s appropriate

. I n updatin g th e staf f pape rwit h respec t t o ne wstudies , w

e hav e use d th e mos t curren t pag e numbers whe n referencin g t o th e lea d criteri a document

. A

s a result , som e o fth e pag e number s cite d wil l diffe rfro m thos e i n earl ydraft s o fth e criteri a document

. I n additio n t o th e staf fpaper , w e woul d als o appreciat e CASAC' s comments an d advic e wit h respec t t o th e lea d exposur e an d ris k assessment

. A t th e meeting , w

e pla n tw o presentations

. Th e firs t wil l revie wi n som e detai l th e exposur e analysi s methodolog yan d preliminar yresults

. A s backgroun d informatio n fo rthi s presentation , I a m enclosin g tw o report sP. 3



### tha t addres s th e exposur e analysi s an drelate ddemographi c data . Th e secondpresentatio nwil l be o nth e initia l result s o f th e leadris k assessment . Th e enclose ddraf t repor t "Estimatin g th e Risk s o f Lead-Induce d Healt hEffects " discusse s i nsome detai l th e result s o f probabilisti c encodin g fo r lead-induce dhemoglobi nan dI Q decrement s (Section s 3 an d4 ) andpreliminar y

estimate s o f risk s o f advers e healt heffect s unde r alternativ e air-lea dscenario s (Sectio n5) . Finally , I hav e decide dt o defe r an y discussio no f th e leadbenefi t analysi s unti l afte r th e Committe e ha s a nopportunit y

t o review

th e exposure/ris kassessment . A s previousl y indicated , w e pla nt o us e a s appropriate , th e result s fro m th e exposure/ris kassessmen t i nth e benefit s analysi s an dtherefore , w e though t i t woul db e pruden t t o wai t onCASA C review

befor e proceedin g further . We lookforwar dt o receivin g you r comment s o nth e scientifi c an

d technica l adequac y

o f th e revise dstaf f pape r an dth e exposure/ris k ^ .. . j.u. U 

### p COrn 

### j n 

### g meeting . By copy o f thi s letter , I a m forwardin g th e othe r Committe e members . assessmen t a t th e thes e material s t o SincecelA*

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# - r 

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. 0 Conno r Directo r 

### Strategie s an

dAi r Standard s Divisio n Enclosure s
cc : CASA C Member s B . Flaa k T . Yosi e