### 1 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION **UNITED ST AT**  **ES ENVIRONMENT AL**  **PROTECTION A GENCY** 

**WA SHINGTON D.C., 20460** 



### PC Code: 1 2 894 0 **Barcode s**  **:** D 41629 3, D 41629 4

**Chemical:** Flutriafol April 3 , 2014 **MEMORANDUM Subject:**  Drinking w ater a ssessment for p roposed n ew u ses (R190 , PP# 3F 8199 ) of

Flutriafol on leafy

vegetables (Group 4), brassica (cole) leafy vegetables (Group 5), grain sorghum , and cotton and (R190, PP# 3F8174) for cucurbit vegetables, fruiting vegetables, strawberries, tree nuts, and wheat uses . **TO:** Tamue Gibson , Risk Manager Reviewer

Cy nthia Giles
- Parker, Branch Chief Fungicide Branch Registration Division (7505P) **FROM:** James K. Wolf, Ph.D., Environmental Scientist

Environmental Risk Branch 3 **REVIEWED BY:**  James A. Hetrick, Ph.D., Senior Science Advisor

Rosanna Louie
- Juzwiak, RAPL Environmental Risk Branch 3 **THROUGH:** Dana Spatz, Branch Chief

Environmental Risk Branch 3 Environment al Fat e and Effects Division (7507P) This memo presents a Tier 1 drinking water assessment for the new uses proposed by the r egistrant in two separate tolerance petitions 3F38199 and 3F8173 requests . The first petition is for Flutriafol Technical (EPA Reg. No. 4787
- 55) , TOPGUARD ® 

### Fungicide (EPA Reg. No. 67760
- 75 1 

### ) , Flutriafol ® 

### 250 g/L Fungicide (EPA Reg No. 67760
- 120 2 

### ) and Flutriafol 500 g / L

1 Topguard Fungicide 67760
- 75 Proposed Label 9 5 2013 for Tol Petition No. 3F8199. 2 Flutriafol 250 g/L SC 67760 129 Proposed Label 9 5 2013 for Tol Petition No. 3F8199 .

### 2

SC Fungicide (67760
- Flutriafol 3 

### )
. The uses proposed with these label amendment s are to add leafy vegetables (Group 4), brassica (cole) leafy vegetables (Group 5), grain sorghum , and cotton use s . The second tolerance petition request s to add the following crop groupings ; Cucurbit Vegetables, Fruiting Vegetables, Strawberries, Tree Nuts, and Wheat to the following labels (EPA Reg. No. 67760
- 75 4 

### ) Flutriafol ® 

### 250 g/L Fungicide (EPA Reg. No. 67760
- 5 

### ) and Supplemental L abel Flutriafol ® 

### 250 g/L (EPA Reg No. 67760
- 6 

### )
. Th e estimated drinking water concentrations (EDWCs) for th is drinking water exposure assessment us e d the FIRST (surface water) and PRZM
- GW (groundwater) models 7 

### and are based upon the maximum number of application s, maximum single and yearl y application rates , and minimum reapplication interval s (Table s 2 and 3 )
. The EDWCs for flutriafol in groundwater and surface water for use in the human health risk assessment are provided in Table 1
. For the proposed new uses, t he EDWCs for flutriafol in surface source drinking water are not expected to exceed 28.2 μg/L for peak and the 2.8 μg /L for long
- term average concentrations. The E D WCs for flutriafol in groundwater source drinking water are not expected to exceed 133 μg/L for peak and the 124 μg/L for long
- term average concentrations. I n previous assessments, similar EDWC s for flutriafol u se on grapes we re predicted using the PRZM
- GW (D412882 8 

### ). EFED recommends that the Health Effects Division use 133 μg/L for the peak concentration and the 124 μg/L for long
- term average concentration in the human health assessment. **Table 1**  **. Maximum Tier**  **I EDWCs in**  **μg/L resulting from**  **the use of flutriafol**  **. Drinking water source (m**  **odel) 1**  **- in**  **- 10 year**  **30 -**  **year simulation** Ac ute Chronic Ac ute Chronic /Cancer Current Assessment Surface water (FIRST) 28.2 2.8 Ground water (PRZM
- GW)
- - **13 3**  **12 4**  Groundwater (SCI
- GROW) 10.3 10.3
- - Previous Drinking Water Assessment (D412882) Surface water (FIRST) 29.48 2.92
- 4.03 Ground water (PRZM
- GW)
- - 132 122 Groundwater (SCI
- GROW) 10.2 10.2
- - 

### Previously , HED determined that the 1,2,4
- triazole (and the triazole conjugates) degradates should be considered residues of concern in the human health risk assessment. 1,2,4
- Triazole and triazole conjugates triazole analine and triazole acetic acid, are common degradates of conazole

3 Flutriafol 500 g / L Proposed Label 67760
- REA 9 5 2013 4 Topguard Fungicide Flutriafol New Uses Eco RA DP 412160 5 67760
- REN Flutriafol 250 Draft Label 6 67760
- REN Flutriafol 250 Draft Supplemental Label. 7 http://www.epa.gov/oppefed1/models/water/models4.htm and http://www.epa.gov/oppefed1/models/water/ 8 Wolf, J. Drinking Water Assess ment for Proposed New Uses (R190, PP# 3F8174) for Flutriafol for the establishment of tolerances for residue on cucurbit vegetables, fruiting vegetables, strawberries, tree nuts, and wheat and label amendment to change the pre
- harvest interval (PHI ) (R298, PP# 3F8156) for field corn and popcorn. D412882, October 29, 2013.

### 3

pesticides, and are addressed in a separate document 9 

### which was prepared by EFED to address the inclusions of 1,2,4
- Triazole and triazole conjugates in Tier 2 drinking water assessments. Due to the persistence of flutriafol, e xposure to 1,2,4
- triazole (and the triazole conjugates) degradates is expected to be very low. Additional detail s concerning these degradates can be found in prior drinking water assessments (D412882 10 

### ). **Proposed New Uses** T OPGUARD ® 

### fungicide is formulated as a s uspension concentrate containing 11.8 % of the active ingredient (a.i.) flutriafol (1.04 lb a.i./gallon of product). Flutriafol ® 

### 250 g/L is formulated as a suspension concentrate containing 22.7% flutriafol (2.08 lb a.i. per gallon of product) and F lutriafol ® 

### 500 g/L is formulated as suspension concentrate containing 42.0% flutriafol (4.16 lb a.i. per gallon of product)
. The proposed methods of application are broadcast foliar by ground and air spray

methods for all the proposed uses except for cott on, where it is proposed that one T
- band (soil applied) will be followed b y a maximum of 2 foliar applications for cotton. Flutriafol may not be applied by chemigation. The labels submitted for the 3F8199 tolerance petition specif ied the maximum allowable rate of use on a per ye ar basis ( i.e
. , lb a.i./A/y ear) , while the labels submitted for the 3F8174 tolerance petition specified a maximum use rate on a per season ( i.e. , lb a.i./A/season) basis
. The number of seasons per year is not specified. For this ass essment it is assumed th at there is only

1 season per y ear. **Table 2. Summary of Proposed New Uses Form**  **ulation (Method of**  **Application) Crop**  **Maximum Single Application Rate**  **lb a.i./A (fl oz/A)**  **Number of Applications (Minimum**  **Reapplication Interval)**  **Maximum Yearly Use Rate lb a.i./A**  **per period (fl oz a.i./A per period**  **)** Broadcast Foliar Spray Leafy Vegetables

(except Brassica Vegetables) 0.114 (7) 4 (7
- day) 0.456 (28 per year) b (AS&GS) Leafy Vegetables

Brassica (cole and celery) 0.114 (7) 4 (7
- day) 0.456 (28 per year) b
Al monds, Pecans, tree nuts 0.114 (14) 4 (7
- day) 0.456 (56 per year) a 0.456 (56 per season) d Al mond & Walnuts 0.114 ( 7) 4 (7
- day) 0.456 (28 per year) b 0.456 (28 per season) e,f Strawberry 0.114 ( 7) 4 (7
- day) 0.456 (28 per season) b 0.456 (28 per season ) e,f Fruiting Vegetables 0.114 (14) 4 (7
- day) 0.456 (56 per year) a 0.456 (56 per season) d Cucurbit Vegetables 0.114 (14) 4 (7
- day) 0.456 (56 per year) a 0.456 (56 per season) d Peanuts 0.114 (14) 4 (14
- day) 0.456 (56 per year) a 0.456 (56 per season) d

9 1,2,4
- Triazole, Triazole Alanine, Triazole Acetic Acid: Drinking Water Assessment in Support of Reregistration and Registration Act ions for Triazole
- derived Fungicide Compounds. 02/28/06. PC 600074, 600011, 600082 D320682. 10 Wolf, J.K. 2013 **.** Drinking Wat er Assessment for Proposed New Uses (R190, PP# 3F8174) for Flutriafol for the establishment of tolerances for residue on cucurbit vegetables, fruiting vegetables, strawberries, tree nuts, and wheat and label amendment to change the pre
- harvest interval (PH I) (R298, PP# 3F8156) for field corn and popcorn. D412882; October 29, 2013.

### 4

**Form ulation**  **(Method of Application)**  **Crop Maximum Single**  **Application Rate lb a.i./A**  **(fl oz/A) Number of Applications**  **(Minimum Reapplication**  **Interval) Maximum Yearly Use Rate**  **lb a.i./A per period (fl oz a.i./A per**  **period )**  To matoes 0.114 ( 7 ) 4 ( 7
- day) 0.456 (28 per season ) b 0.456 (28 per season ) e,f Wheat (spring
- winter) 0.114 (14) 2 (7
- day) 0.228 (28 per year) a 0.228 (28 per season) d Grain Sorghum 0.114 (14) 2 (7
- day) 0.228 (28 per season) a Soil Applied Broadcast Foliar Spray Cotton (T
- Band) 0.26 0 ( 8) 1 at plant 0.26 0 ( 8/season) c

Cotton (Foliar) 0.114 (14) 2 Foliar (7
- day) 0.228 (28/year) a,b Total Cotton [T
- Band + Cotton Foliar] 0.26 ( 8) 0.228 (2 x 7) Combined 0.488 lb a.i./A/year a,b,c **Submitted Proposed Draft Labels.** File ID (name) of Submitted Proposed Label Proposed Label [Product, EPA Reg. #; % a.i., lb a.i./fl oz] Maximum Rate Expressed in lb a.i./A/period DP Barcode D412294; D415850 Tolerance Petition 3F8199 a Topguard Fungicide 67760
- 75 Proposed Label 9 5 2013 for Tol Petition No. 3F8199 Topguard ® Fungicide 67760
- 75 [11.8% a.i.; 0.008125 lb a.i./fl oz] lb a.i./A/year b Flutriafol 250 g/L SC 67760 129 Proposed La bel 9 5 2013 for Tol Petition No. 3F8199 Flutriafol ® 250 g/L SC Fungicide 67760
- 120 [22.7% a.i.; 0.01625 lb a.i./fl oz] lb a.i./A/year

c Flutriafol 500 g/L Proposed Label 67760
- REA 9 5 2013 Flutriafol ® 500 g/L SC Fungicide 67760
- REA [42.0% a.i.; 0.0325 lb a.i./fl oz] (lb a.i./A/season DP Barcode: D412160 ; Tolerance Petition 3F8174 d Flutriafol New Uses Eco RA DP 412160 667760
- 75 Topguard ® Fungicide 67760
- 75 [11.8% a.i.; 0.008125 lb a.i./fl oz] lb a.i./A/season

e 67760
- REN Flutriafol 250 draft label Flutriafol ® 250 g/L Fungicide 67760
- REN [22.8% a.i.; 0.01625 lb a.i./fl] lb a.i./A/season f 67760
- REN Flutriafol 250 Draft Supplemental La bel Flutriafol ® 250 g/L Fungicide 67760
- REN Draft Supplemental La bel [22.8% a.i.; 0.01625 lb a.i./fl] lb a.i./A/season 

### Altho ugh, three different product formulations are proposed which contain differen t amounts (lb per gallon) of active ingredient (11.8, 22.8, and 42.0% a.i.), the maximum single application rates are the same for all three formulations when applied foliarl y (0.114 lb a.i./A) are the same
. A higher single application rate is proposed for the soil applied (T
- Band ) use for cotton (0.26 lb a.i./A). For the foliar uses, up to four 0.114 lb a.i./A applications per ye ar (0.456 lb a.i./A/y ear) may be applied (except grain sorghum where onl y 2 are proposed). For cotton, it is proposed that one 0.26 lb a.i./A T
- Band appli cation follow by a maximum of 2 foliar appli c ations (0.114 lb a.i./A) for a ye arly

maximum of 0.488 lb a.i./A/year.
**Table 3**  **. Maximum**  **Flutriafol Application Rates for Proposed New Uses.**

**Crop or Crop Group Ma**  **xim um Single**  **Application Rate (lb a.i./A)**  **Number of Applications**

**(Minim um**  **Reapplication Interval)**  **Ma xim**  **um Yearly**  **Use Rate (lb a.i./A**  **/year )**  All uses except Grain Sorghum and Cotton 0.114 4 (7
- day ) 0.456

Grain sorghum 0.114 2 (7
- day ) 0.228 Cotton T
- Band Appl. 0.26 0 (T
- band, at plant) 0.26 0

Foliar 0.114 2 (Foliar, 7
- day ) 0.228 Combined for Cotton 0.228 0.260 2 (Foliar, 7
- day )

1 (T
- Band Appl ) 0.448

### 5

**Environmental Fate and Transport Characterization**  Flutriafol is expected to be persistent in soil and moderatel y mobile in the environment, with its major routes of dissipation by runoff and leaching through the soil and through biotic degradation in aquatic environments (Table 4 )
. F lutriafol is expected to dissipate slowly with a half
- life of ye ar s [ n ever achieved in studies] in the terrestrial environment and therefore repeated applications may

lead to accumulation of flutriafol residues in soil. Flutriafol is expected to reach surface water through drift, runoff , and leaching
. Additionally , it is ex pected to leach into groundwater. Detailed information on t he environmental fate of flutriafol can be found in prior assessments (D360863, D356830, D340508 , D396757 ). **Table 4**  **. Summary of physical/chemical and environmental fate and transport properties of flutriafol. Parameter**  **Value(s) (units) Source (MRID)**  **Comment** Chemical Name Flutriafol CAS Name: α - (2
- fluorophenyl)
- α - (4
- fluorophenyl)
- 1H
- 1,2,4
- triazole
- 1
- ethanol

IUPAC Name: (RS
- 1
- (2
- fluorophenyl)
- α - (4
- fluorophenyl)
- 1H
- 1,2,4
- triazole
- 1
- ethanol 47129901 -

Chemical Structure
-

Molecular Formula C 16 H 13 F 2 N 3 O 47129901
- Molecular Weight 301.3 amu 47129901
- Solubility (20 ° C) 130 mg/L or ppm 47129901
- Vapor Pressure (20 ° C) 4 x 10 - 7 Pa 3.00025x10 - 9 torr 47129901
- Henry’s Law constant 9.16 x10 - 12 atm m 3 /mol
- Calculated pK a (20 ° C) 2.3 47129901
- Octanol
- Water Partition Coefficient (log K OW @ pH 7) 2.29 47129901
- Hy droly sis Half

- life (t 1⁄2 ) pH 5 and 7 Stable 47090416 Stable at all pHs. Aq ueous Photolysis Half
- life (t 1⁄2 ) Stable 47090417
-

### 6 **Parameter Value(s) (units)**  **Source (MRID) Comment**  Soil Photolysis Half

life (t 1⁄2 ) Stable 47090420 47418401 D353179

D350986 Aerobic Soil Metabolism Half

- life (t 1⁄2 ) 69 7 we eks 120, 161, 257, 84, 98, and 315 we eks 347, 239, and 3,466 w eeks 47090421 47090422 47090423 Note: values in

weeks Anaerobic Aquatic Metabolism (t 1⁄2 ) t 1/2 = 6,932, 840, 1127, 1799, 588, 686, 2205 days 47090424 ( T otal system) Aerobic Aquatic Metabolism t 1/2 = 42.6 and 36.3 days 47090419 ( T otal system) Organic Carbon Partition Coefficient (K OC ) 498, 205, 379, 230, 340, 428, 140 mL/g OC 47090425 47090426 47090427 -
Soil Partition Coefficient (K d ) 3.7, 13.6, 10.6, 6.5, 2.0 mL/g 47090425 47090426 47090427 -
Terrestrial Field Dissipation Half
- life (t 1⁄2 ) t 1/2 = 1155 days 3466 days 2310 days 1155, 866, 770, 866, 1155, 1386 days 47115502 47090431 - Loamy sand.

- Clay loam.

- Sandy clay loam.

- Study conducted at 6 sites in Germ any, s oil texture class es were not reported. 

### No major degradation products ( i.e. , > 10% of applied radioactivity ) were identified in any water or soil studies
. No major flutriafol degradates have been identified in an y submitted studies . The degradates formed in laboratory studies are discussed in detail in prior assessments ( D412882 )
. Two minor degradation products 11 

### were identified in the photoly sis on soil study [ 1H
- 1,2,4
- Triazole and 2,4’
- Difluorobenzophenone] and three minor [1H
- 1,2,4
- Triazole; Triazole
- 1
- acetic acid; 1,2,4
- Triazole
- 1
- alanine] degradation products were identified in the anaerobic aquatic metabolism study

( Figure 1 ).

11 Note the previous drinking water assessment (D360863) incorrectly included the 1,2,4
- Triazole
- 1
- acetic acid degradate. This error would not change the estimated drinking water concentrations (EDWCs).

### 7 1,2,4
- Triazole (1,2,4
- T; free triazole) Triazole Alanine (TA) Triazole Acetic Acid (TAA) **Figure 1. Chemical structures for 1,2,4**  **- triazole, triazole alanine, and triazole acetic acid**  

### With the exception of 1,2,4
- triazole (and the triazole conjugates), none of the other flutriafol degradates noted above were considered of concern by HED. 1,2,4
- Triazole and triazole conjugates triazole analine and triazole acetic acid, common degradates of conazole pesticides, were addressed in a separate document 12 

### which was prepared b y EFED to address the inclusions of 1,2,4
- Triazole and triazole conjugate s in Tier 2 drinking water assessments. The Tier 2 Triazole drinking water assessment was designed to be conservative. B ecause of the persistence of flutriafol, the percentages of 1,2,4
- triazole residues formed b y the degradation of flutriafol are expected to be much lower than other conazoles pesticides considered in drinking water assessment s . T herefore, the assessment for the conazole class of pesticides should still be conservative. Six terrestrial field dissipation studies with applications made over several consecutive years, most with applications over multiple y ears, also indicate that flutriafol residues will remain essentially un - degraded, allowing residues to carry
- over from y e ar to ye ar under actual use conditions **.** Due to the length of the environmental fate studies, and the persistence of flutriafol, major degradates were not detected in either laboratory or field studies. Limited monitoring data supports the potential for flutriafol to leach to groundwater. Flutriafol was detected (0.0051 μg/L) in groundwater in a study conducted in Ireland 13 

### . Seven flutriafol detections (detection limit = 0.021 μg/L) were reported in three public wells in the United Kingdom, during a three ye ar period (June 2000 to February 2003) 14



### . **Modeling** Th e Tier 1 drinking water assessment us e s the PRZM
- GW and SCI
- GROW models for groundwater and the FIRST model for surface water
. Both SCI
- GROW and FIRST are not scenario specific, so the estimated concentrations are based upon the environmental fate properties and the maximum application number and rates and minimum reapplication interval
.

12 1,2,4
- Triazole, Triazole Alanine, Triazole Acetic Ac id: Drinking Water Assessment in Support of Reregistration and Registration Actions for Triazole
- derived Fungicide Compounds. 02/28/06. PC 600074, 600011, 600082 D320682. 13 Regional Groundwater Monitoring Network, 2005. Northern I reland. Environmental & He ritage Service. http://www.doeni.gov.uk/niea/groundwater_2005_report.pdf
. 14 Stuart et al. 2006. http://onlinelibrary.wiley.com/doi/10.1111/j.1745
- 6592.2006.00113.x/pdf N H N N N N N

N H 2

O O H N N N O
O H

### 8

The six standard PRZM
- GW scenarios 15 

### used i n the groundwater simulations were developed to be representative of known vulnerable sites

— shallow, unconfined aquifers under an agricultural field with leaching prone soil and adequate precipitation and/or irrigation . O utput values represent pesticide co ncentrations that may be observed in private drinking water wells resulting from the use of groundwater vulnerable to pesticide c ontamination. The results are expected to represent the upper bound values on the concentrations of flutriafol that might be fo und in drinking water supplied by vulnerable groundwater sources. The selection and procedures for selecting model input parameters followed EFED guidance 16



### . Ground w ater Concentrations PRZM
- GW (Version 1.0 1 ) is a graphical user interface (GUI) for running the P esticide R oot Z one M odel (PRZM) to estimate exposure in a shallow, unconfined, aquifer following pesticide application to an agricultural field. PRZM was developed b y the U.S. EPA to simulate the vertic al movement of pesticides in the unsaturated soil, within and below the plant root zone, and extending to the water table using generall y available input data (Carsel et al., 1984 17 

### ). PRZM is also currentl y used b y EFED in combination with EXAMS 18 

### to estimat e pesticide concentrations in surface water. Groundwater EDWCs with PRZM
- GW are simulated for 30 y ears as done with PRZM/EXAMS for surface water. Unlike SCI
- GROW, estimated groundwater concentrations are influenced b y both the soil and hy drology of the spe cific scenario. The SCI
- GROW model considers onl y a single year ’ s application. The basic input require ments for PRZM
- GW are summarized in Table 5
. The mean ( 4,048 day s) and 90 percent upper bound of the mean ( 7,202 day s ) aerobic soil metabolism half
- lives were recalculated. It should be also noted that the EFED guidance on model input parameter selection and preparation has evolv e d over time. Following current model input guidance, the mean K oc 

### (322 mL /g oc 

### ) was used with the PRZM
- GW and FIRST models because t he sorption coefficients (K d 

### ) values were significantly correlated [r 2 

### = 0.84; F test regression; p
- value=0.0024] to the soil organic carbon content (OC). In prior assessments [D360863] the lowest K oc 

### (140 mL /g oc 

### ) was used with the FIRST model (which followed guidance applicable at time , and has since been updated ) and SCI
- GROW ( consistent with current guidance ). The percent crop area (PCA ) 19 

### i s 0.91. Because this version of PRZM
- GW does not allow for multiple application methods the results from the T
- Band and foliar applications are run separatel y and the results are added together. **Table 5**  **. PRZ M**  **- GW input param**  **eter values for flutriafol. Param**  **eter (units) Value**  **Source (M**  **RID) Comment**  Organic Carbon Partition Coefficient (K oc ; mL/g oc ) 322 47090425 47090426 47090427 Represents the mean value of seven values

ranging from 140 to 498 mL/g for the parent compound.

15 Florida Citr

us, Florida Potato, Wisconsin Corn, Georgia Peanuts, North Carolina Cotton, and Delmarva Sweet Corn. 16 http://www.epa.gov/oppefed1/models/water/input_parameter_guidance.h tm 17 Carsel, R.F.; Smith, C.N.; Mulkey, L.A.; Dean, J.D; Jowise, P. Users Manual for the P esticide R oot Z one M odel (PRZM) Release 1. December 1984. EPA
- 600/3
- 84
- 109. Environmental Research Laboratory, Office of Research and Development, U.S. Environmenta l Protection Agency, Athens, GA, 227 pp. 18 B urns, L. A. 2002. EXAMS ( Ex posure A nalysis M odeling S ystem) Version 2.98.04.06. Environmental Research Laboratory. U. S. Environmental Protection Agency. Athens, GA. 19 http://www.epa.gov/oppefed1/models/water/pca_adjustment_dw a.html

### 9

**Param eter (units)**  **Value Source**  **(M RID)**  **Comment**
Aerobic Soil Metabolism Half
life (t 1⁄2 ) (days) 7,2 0 2 days 47090421 47090422 47090423 Recalculated value the r epresents 90%

confidence interval for 10 values f rom the aerobic soil metabolism of the parent compound. (See Appendix 1) Application Rates, Number, Interval See Table 2
- Specified on label Application Date : T
- Band Foliar Application - 7 days b .e. 101 days a.e. Application can be specified by date or by days before or after crop emergence. b.e.
- before emergence (defined by scenario) a.e. - after emergence (defined by scenario) 

### The SCI
- GROW 20 

### model (Version 2.3) is also used as a groundwater screening exposure value to be used in determining the potential risk to human health from drinking water contaminated with the pesticide. Fate input parameters used in SCI
- GROW are presented in Table 7.
**Table 7. SCI -**  **GROW (v2.3) input par am**  **eter values for flutriafol. Param**  **eter (units) Value**  **Source (M**  **RID) Comment**  Organic Carbon Partition Coefficient (K oc ; mL/g oc ) Lo west: 140 47090425 47090426 47090427 Represents the lowest non
- sand (texture

class) value of seven values ranging from 140 to 498 mL/g for the parent compound. Aerobic Soil Metabolism Half
- life (t 1⁄2 ) (days) Mean= 4,047.6 47090421

47090422 47090423 Mean value of the 10 aerobic soil

metabolism of the parent compound. 

### The peak groundwater EDWCs estimated by PRZM
- GW ranged from 28 to 133 μg/L and the simulation averages ranged from 21 to 124 μg/L (Table 6). The Florida Central Ridge and North Carolina Eastern Coastal Plains had the highest EDWCs. The maximum EDWCs estimated for the proposed uses are essentially the same as the maximum EDWCs most recent EDWCs for flutriafol (parent) are 132 μg/L for acute exposure and 122 μg/L for chronic/cancer exposure (D412882 21 

### ). The differences are due different fat e properties ( i.e., aerobic soil half
- life) and different application dates. Representative PRZM
- GW and SCI
- GROW input files are given in Appendix 2.

20 http://www.epa.gov/oppefed1/models/wate r/#scigrow 21 Wolf, J. Drinking Water Assessment for Proposed New Uses (R190, PP# 3F8174) for Flutriafol for the establishment of tolerances for res idue on cucurbit vegetables, fruiting vegetables, strawberries, tree nuts, and wheat and label amendment to change the pre
- harvest interval (PHI ) (R298, PP# 3F8156) for field corn and popcorn. D412882, October 29, 2013.

### 10

**Table 6**  **. PRZ M**  **- GW (Version 1.01) estim**  **ates of f**  **lutriafol for the proposed new uses. Flutriafol**  **SCI -**  **GRO W**  **(1 Year Simulation)**  **PRZ M**  **- GW**  **(version 1.03) (30 Year Sim**  **ulation) Scenario**  **(μg/L) Peak (μg/L)**  **P ost**  **B reakthrough**  **Average (μg/L) Ave**  **rage**

**Breakthrough Time (days)**  Grain Sorghum 2 applications @ 0.114 lb a.i. /A ; 7
- day reapplication interval Delmarva 4.8 50.3 43.2 2872 Florida Central Ridge 51.4 44.6 2865 Florida
- potato 30.1 26.5 7035 GA
- Southern Coastal Plain 24.6 21.6 6245 NC Eastern Coastal Plain
- 61.6 51.7 3664 WI Central Sands 61.9 57.7 4018

4 applications @ 0.114 lb a.i. /A ; 7
- day reapplication interval Delmarva 9.6 100 86.4 2872 Florida Central Ridge
- citrus 103 89.2 286 5 Florida

– potato 30 yr 60.3 53.2 7031 GA
- Southern Coastal Plain 49
. 2 43.2 6245 NC Eastern Coastal Plain
- 123 104 3664 WI Central Sands 124 115 4018 Cotton 1 applications @ 0. 26 a.i. /A T
- Band Application Delmarva
5.5 57.4 49.6 2872 Florida Central Ridge 58.9 50.4 2865 Florida

– potato 34.5 30.5 7035 GA
- Southern Coastal Plain 28 25 6245 NC Eastern Coastal Plain
- 70.6 58.7 3664 WI Central Sands 71.6 66.7 4018 Cotton 2 applications @ 0. 114 a.i./A ; 7
- day reapplication interval (w ith the T
- Band Application) Delmarva 4.8 50.3 43.2 2872 Florida Central Ridge 51.4 44.6 2865 Florida

– potato 30.1 26.5 7035 GA
- Southern Coastal Plain 24.6 21.6 6245 NC Eastern Coastal Plain
- 61.6 51.7 3664 WI Central Sands 61.9 57.7 4018

Cotton 1 application @ 0.26 lb a.i./A and 2 @ 0.114 lb a.i./A (7
- day interval ) Delmarva 10.2 107.7 92.8 2872 Florida Central Ridge 110.3 95.0 2864 Florida

– potato 64.6 57.0 7035 GA
- Southern Coastal Plain 52.6 46.6 6245 NC Eastern Coastal Plain
- 132.2 110.4 3664 WI Central Sands 133.5 124.4 4018

### 11

Surface Water Concentrations OPP uses the Tier 1 model, F QPA I ndex R eservoir S creening T ool (FIRST , Version 1.1.1 ) 22 

### , to estimate both acute and chronic potential pesticide concentrations in untreated surface source drinking water. Input parameters for FIRST are listed in Table 8
. For the foliar spray the aerial spray option in FIRST was used for the foliar applications and the ground spray T
- Band option was used for cotton T
- Band assessment. For the proposed new cotton use where 1 T
- Band application (@ 0.26 lb a.i./A) is follow by 2 foliar applications (@ 0.114 lb a.i./A), the method s are simulated separatel y and added together.
**Table 8**  **. FIRST (v1. 1**  **.1 )**  **environm ental fate and other select**  **input param eter values for**  **current flutriafol**  **assessment .** 

**P arameter**  **(units) V**  **alue S**  **ource (MRID) C**  **omment** Percent Cropped Area (decimal) 0. 91 National default Soil Partition Coefficient ( K OC mL/g OC ) 322 47090425 47090426 47090427 Represents the mean of seven values ranging

from 140 to 498 mL/g for the parent compound. Aerobic Soil Metabolism Half
life (t 1⁄2 ) (days) 7,202 47090421 4709042 2 4709042 3 Recalculated value the represents 90% confidence

interval for 10 values from the aerobic soil metabolism of the parent compound. (See Appendix 1)
. Wetted in (y es or no) No Proposed label Not specified Pesticide Application Method [Default Options in FIRST] A B Label T
- band option Air Spray Drift=16.0%; Efficiency =0.95%

Ground Spray Drift=6.4%; Efficiency 0.99%; Depth of Incorporation (inches)
- 1.5 For air spray depth is n ot specified For T
- Band a n inc orporation d epth is required Solubility in Water @ 20 O C, (m g/L or ppm) 130 47129901
- Aerobic Aquatic Metabolism Half
- life (t 1⁄2 ) (days) 49.2 47090419 Represents the 90 th percentile of the upper confidence bound on the mean of nine half
- life values (39.5). Hy droly sis Half

- life @ pH 7 0 47090416 Stable Aq uatic Photolysis Half

- life (t 1⁄2 ) @ pH 7 0 47287601 47090417 Stable 

### The flutriafol application rate information and surface water EDWCs are given in Table 9
. Output from FIRST is presented in Appendix 3
. The highest EDWC s are for the four foliar applications associated with the proposed use on leafy vegetable s and grain sorghum . The maximum EDWCs are 28.2 and 2.8 μg/L for the acute a nd chronic exposure concentrations , respectivel y . Representative FIRST outputs are given in Appendix 3. **Table 9**  **. Tier 1**  **FIRST Esti**  **mated Drinking Water Concentrations (EDWCs) for flutriafol for the proposed new uses**  **.**
22 http://www.epa.gov/oppefed1/models/water/#first

### 12

**Use Single** 

**Application Rate**  **(lb a.i. /A**  **) Number of** 

**Applications (interval) Me**  **thod of Application Seasonal**  **Application Rate (lb a.i.**  **/A /**  **year )**  **Acute**

**EDWC (μg/L)**  **Chronic**

**EDWC (μg/L)**  Leafy Vegetables 0.114 4 (7
- days) Foliar 0.456 28.2 2.8 Grain Sorghum 0.114 2 (7
- days) Foliar 0.228 14.2 1.4 Grain Sorghum 0.114 4 (7
- days) Foliar 0.456 28.2 2.8 Cotton 0.114 2 (7
- days) Foliar 0.228 14.2 1.4 Cotton 0.26 0 1 (
- ) T
- Band 0.260 10.9 1.1 Cotton
- a 1 T
- Band + 2 Foliar 0.488 25.1 2.6

a 0.26 lb a.i./A + 2 @ 0.114 lb a.i./A

### 13

**Appendix 1. Discussion**  **on Aerobic Soil Metabolism Half -**  **lives**
. In several previous drinking water exposure assessments, the aerobic soil metabolism half
- life value (588 day s) was used as an input for groundwater modeling was incorrect ( e.g., a unit error). The 90% upper bound on the mean was reported incorrectl y as 588 days when it should have been reported as 588 weeks. This value, however, also appears to be the shortest half
- life and not a mean or upper bound of the mean. The value was recalculated for day s with a mean (3 , 95 7 day s) and 90 th 

### percent upper bound of the mean (7 , 515 day s) aerobic soil metabolism half
- lives were recalculated in a response to the registrant concerning the PRZM
- GW model (D396757). This error has no influence on the surface water EDWCs estimated using the FIRST model. Because the FIRST model is insensitive to half
- lives greater than 365 day s, it wa s assumed for modeling purposes that there was no aerobic soil degradation, based upon the flutri afol aerobic soil metabolism studies where all the half
- lives were greater than 365 day s. PRZM
- GW has been found to be more much more sensitive to the aerobic soil metabolism half
life value selected for modeling potential groundwater contamination compare d to surface water estimates with FIRST or PRZM/EXAMS Since the last drinking water assessments (D412882 10/29/13 and D396757 07/26/12), th e registrant has submitted a report (MRID 49177401) questioning several of the aerobic soil metabolism half

- lives u sed to obtain the 90% upper bound on the mean half
- life for modeling purposes 23 

### . While no new data has been submitted, EFED has considered the information submitted in the report (MRI D 49177401). The half
- lives e stimated by

the EPA (DERS) and the registra nt (Table 5, MRI D 49177401) , using linear and nonlinear regression techniques , we re compared in Table 5 of MRI D 49177401. While the values [linear compared to nonlinear] are not exactly the same (numericall y), they are similar (generally

vary ing onl y b y 1 or 2 weeks) with the exception of the North Dakota soil (MRI D 47090421) and the Spey er 2.2 sand soil (MRI D 47090423). The North Dakota and the Spey er 2.2 soils are discussed in more detail in a following paragraph. The (paired) linear and nonlinear methods yi elded similar half
- lives (ranging from 83 weeks to 3,446 weeks). As noted in the registrants report (MRID 49177401) , several of the soils tested did not result in statistically

meaningful r 2 

### and p
- values for linear regression or nonlinear regression. This suggest s that either no aerobic metabolism of flutriafol occurred during the course of the stud y or that no clear degradation pattern was observed (i.e., lower value followed by higher values resulting in regression with positive slopes ) . Therefore , t he data illustrate the high persistence of flutriafol in aerobic soils. It should be noted here that these studies were conducted for a periods ranging from 126 to 365 day s (MRIDs # 47090421 , 47090422 , 47090423 ) and since man y of the studies showed very little degradation the DT 50s 

### , or half
- lives, had to extrapolate far bey ond the length of the stud y.

23 http://www.epa.gov/oppefed1/models/water/input_parameter_guidance.htm

### 14

One of two of the half

- life values specificall y noted was for the North Dakota sandy loam (MRI D 47090421), where the registrant indicates that the half
- li fe of 4,878 day s (regression slope =
- 1.4419e - 4 

### ) would be a better estimate rather than the 6,932 day s (regression slope =

- 1.00e - 4 

### ) reported b y the EPA in the DER. Note: both slope values are available with Sigma Plot output and p age 50 of the study MRID 47090701 has the identical regression equation slope (

- 0.0001) and intercept calculated by the EPA and included in the DER
. The difference (4,878 and 6,932 day s) is solely

based upon the significant figures of slope derived from the regression anal ys is. Bo th half

- life values suggest minimal aerobic metabolism of flutriafol in soil, although the half
- life estimated from the slope has more significant figures may be a better estimate. The Spey er 2.2 sand (MRID 47090423) had a report half
- life of 24,252 day s (3,466 weeks) which indicates little if any aerobic soil metabolism took place during the stud y. No information has been provided as to wh y this soil should not be included. The EPA also noted that a third soil (Warfield soil) from MRID 47090423 study had not been included previously when determining the upper bound of the mean for modeling purposes and has been added
. The half
- lives from these studies are summarized in **Appendix1 Table**  **1** and the 90 th 

### percent upper bound on the mean for modeling purposes is recalculated the inclusion of the Warfield soil and updated half

- life for the North Dakota soil with and without the Spey er 2.2 soil . The upper bound on the mean of all soils (n=10) is 7,2 0 2 days, which is slightly less than previous value of 7, 470 day s (n=9) , because of the addition of the Warfield soil. **Appendix 1**  **Table 1**  **. Summary of Aerobic Soil Metabolism Study Half -**  **Lives and Upper of Mean for Modeling.**  **MRID # Soil Identification**  **Half -**  **life (weeks)**  **a Half** 

**- life**  **(weeks) b**  **Half**

**- life**  **(weeks) c**  **Half**

**- life**  **(days) (weeks**  **c x 7)**  47090421 ND soil
- - 69 7 4,878 47090422 18 acres (both labels) 121 1 20 1 20 837 47090422 F lexford 257 257 257 1,797 47090422 B oxford 98 9 8 9 8 683 47090422 H orsely 84 8 4 8 4 585 47090422 F rensham (both

labels) 161 161 161 1,127 47090422 C halgrove 315 315 315 2,205 47090423 S pey er 2.3 347 347 347 2,429 47090423 W arfield 239 239 239 1 , 673 47090423 S pey er 2.2 3,466 3 , 466 3 , 466 24,262 90% upper bound on mean all values = 7,201.9 days (mean = 4,047.6; std = 7,212.48, n = 10) c
a Values used to calculate 7,515 day upper bound half
- life ( Table 2; D396757) ; note 121 week value for the 18 acre soil compared to 120 week value
. b Values used to calculate the 7,470 day upper bound half
- life ( Tables 4 and 5; D412882); ND soil 697 weeks not included. c Values used to calculate the 7,202 day upper bound half
- life

### 15

**Appendix 2**  **. GROUNDWATER**  **PRZM -**  **GW Input and Output 1**  **T -**  **BAND APPLICATION @ 0.26 lb a. i./A**  3/18/2014 12:08:46 PM; Flutriafol; Wisconsin Corn
- WI Central Sands User I nterface Version: PRZM
- GW (Version 1.01) ***Record 3 0.76 0.36 0 18 1 1 ***Record 6 0 ***Record 8 1 ***Record 9 1 0.25 90 100 1 10 10 10 0 100 ***Record 10 30 ***Record 11 01 0561 210761 201061 1 010562 210762 201062 1 010563 210763 201063 1 010564 210764 201064 1 010565 210765 201065 1 010566 210766 201066 1 010567 210767 201067 1 010568 210768 201068 1 010569 210769 201069 1 010570 210770 201070 1 010571 210771 201071 1 010572 210772 201072 1 010573 210773 201073 1 010574 210774 201074 1 010575 210775 201075 1 010576 210776 201076 1 010577 210777 201077 1 010578 210778 201078 1 010579 210779 201079 1 010580 210780 201080 1 010581 210781 201081 1 010582 210782 201082 1 010583 210783 201083 1 010584 210784 201084 1 010585 210785 201085 1 010586 210786 201086 1 010587 210787 201087 1 010588 210788 201088 1 010589 210789 201089 1 010590 210790 201090 1 ***Record 12 Place Holder ***Record 13 30 1 0 0 ***Record 15 Place Holder ***Record 16 24 461 0 1 4 0.291 1 0 24 462 0 1 4 0.291 1 0 24 463 0 1 4 0.291 1 0 24 464 0 1 4 0.291 1 0 24 465 0 1 4 0.291 1 0 24 466 0 1 4 0.291 1 0 24 467 0 1 4 0.291 1 0 24 468 0 1 4 0.291 1 0 24 469 0 1 4 0.291 1 0 24 470 0 1 4 0.291 1 0 24 471 0 1 4 0.291 1 0 24 472 0 1 4 0.291 1 0

### 16

24 473 0 1 4 0.291 1 0 24 474 0 1 4 0.291 1 0 24 475 0 1 4 0.291 1 0 24 476 0 1 4 0.291 1 0 24 477 0 1 4 0.291 1 0 24 478 0 1 4 0.291 1 0 24 479 0 1 4 0.2 91 1 0 24 480 0 1 4 0.291 1 0 24 481 0 1 4 0.291 1 0 24 482 0 1 4 0.291 1 0 24 483 0 1 4 0.291 1 0 24 484 0 1 4 0.291 1 0 24 485 0 1 4 0.291 1 0 24 486 0 1 4 0.291 1 0 24 487 0 1 4 0.291 1 0 24 488 0 1 4 0.291 1 0 24 489 0 1 4 0.291 1 0 24 490 0 1 4 0.291 1 0 ***Record 17 0 1 0 ***Record 19 Place Holder ***Record 20 1000 0 0 0 0 0 2 1 1 0 ***Record 26 0 0 0 ***Record 27 3 0.1 0.7 4.0 ***Record 31 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.97 10.0 ***Record 32 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 ***Record 32A 2.00 25.0 ***Record 33 8 *** Record 34,36,37 Horizon 1 1 10 1.63 0.088 0 0 0 9.62E
- 059.62E
- 05 0 1 0.088 0.034 0.46 1. 4812 5.6 95 2.3 0 0 *** Record 34,36,37 Horizon 2 2 10 1.63 0.088 0 0 0 9.09E
- 059.09E
- 05 0 5 0.088 0.034 0.46 1.4812 5.6 95 2.3 0 0 *** Record 34,36,37 Horizon 3 3 20 1.68 0.079 0 0 0 7.49E
- 057.49E
- 05 0 20 0.079 0.025 0.14 0.4508 5.6 96 2.5 0 0 *** Record 34,36,37 Horizon 4 4 20 1.68 0.079 0 0 0 5.35E
- 055.35E
- 05 0 20 0.079 0.025 0.09 0.2898 5.6 96 2.5 0 0 *** Record 34,36,37 Horizon 5 5 20 1.59 0.068 0 0 0 3.21E
- 053.21E
- 05 0 20 0.068 0.016 0.09 0.2898 5.6 97 1.7 0 0 *** Record 34,36,37 Horizon 6 6 20 1.59 0.068 0 0 0 1.07E
- 051.07E
- 05 0 20 0.068 0.016 0.08 0.2576 5.6 97 1.7 0 0 *** Record 34,36,37 Horizon 7 7 800 1.59 0.068 0 0 0 0 0 0 50 0.068 0.016 0.07 0.2254

### 17 5.6 97 1.7 0 0 *** Record 34,36,37 Horizon 8 8 100 1.59 0.396 0 0 0 0 0 0 50 0.396 0.001 0.07 0.2254 5.6 97 1.7 0 0 *** Record 40 0 *** Record 42 YEAR 10 YEAR 10 YEAR 10 0 *** Record 45 3 YEAR *** Record 46 DCON1 TAVE 33 34 1.0E3 IN FL TCUM 33 33 0.00233 IR RG TSER



### 4 Foliar Applications @ 0.114 lb a.i./A 3/18/2014 12:10:17 PM; Flutriafol; Wisconsin Corn
- WI Central Sands User Interface Version: PRZM
- GW (Version 1.01) ***Record 3 0.76 0.36 0 18 1 1 ***Record 6

0 ***Record 8

1 ***Record 9

1 0.25 90 100 1 10 10 10 0 100 ***Record 10 30 ***Record 11 010561 210761 201061 1 010562 210762 201062 1 010563 210763 201063 1 010564 210764 201064 1 010565 210765 201065 1 010566 210766 201066 1 010567 210767 201067 1 010568 210768 201068 1 010569 210769 201069 1 010570 210770 201070 1 010571 210771 201071 1 010572 210772 201072 1 010573 210773 201073 1

### 18 010574 210774 201074 1 010575 210775 201075 1 010576 210776 201076 1 010577 210777 201077 1 010578 210778 201078 1 010579 210779 201079 1 010580 210780 201080 1 010581 210781 201081 1 010582 210782 201082 1 010583 210783 201083 1 010584 210784 201084 1 010585 210785 201085 1 010586 210786 201086 1 010587 210787 201087 1 010588 210788 201088 1 010589 210789 201089 1 010590 210790 201090 1 ***Record 12 Place Holder ***Record 13 120 1 0 0 ***Record 15 Place Holder ***Record 16 10 861 0 1 4 0.128 1 0 17 861 0 1 4 0.128 1 0 24 861 0 1 4 0.128 1 0 30 861 0 1 4 0.128 1 0 10 862 0 1 4 0.128 1 0 17 862 0 1 4 0.128 1 0 24 862 0 1 4 0.128 1 0 30 862 0 1 4 0.128 1 0 10 863 0 1 4 0.128 1 0 17 863 0 1 4 0.128 1 0 24 863 0 1 4 0.128 1 0 30 863 0 1 4 0.128 1 0 10 864 0 1 4 0.128 1 0 17 864 0 1 4 0.128 1 0 24 864 0 1 4 0.128 1 0 30 864 0 1 4 0.128 1 0 10 865 0 1 4 0.128 1 0 17 865 0 1 4 0.128 1 0 24 865 0 1 4 0.128 1 0 30 865 0 1 4 0.128 1 0 10 866 0 1 4 0.128 1 0 17 866 0 1 4 0.128 1 0 24 866 0 1 4 0.128 1 0 30 866 0 1 4 0.128 1 0 10 867 0 1 4 0.128 1 0 17 867 0 1 4 0.128 1 0 24 867 0 1 4 0.128 1 0 30 867 0 1 4 0.128 1 0 10 868 0 1 4 0.128 1 0 17 868 0 1 4 0.128 1 0 24 868 0 1 4 0.128 1 0 30 868 0 1 4 0.128 1 0 10 869 0 1 4 0.128 1 0 17 869 0 1 4 0.128 1 0 24 869 0 1 4 0.1 28 1 0 30 869 0 1 4 0.128 1 0 10 870 0 1 4 0.128 1 0 17 870 0 1 4 0.128 1 0 24 870 0 1 4 0.128 1 0 30 870 0 1 4 0.128 1 0 10 871 0 1 4 0.128 1 0 17 871 0 1 4 0.128 1 0 24 871 0 1 4 0.128 1 0 30 871 0 1 4 0.128 1 0 10 872 0 1 4 0.128 1 0 17 872 0 1 4 0.128 1 0 24 872 0 1 4 0.128 1 0

### 19 30 872 0 1 4 0.128 1 0 10 873 0 1 4 0.128 1 0 17 873 0 1 4 0.128 1 0 24 873 0 1 4 0.128 1 0 30 873 0 1 4 0.128 1 0 10 874 0 1 4 0.128 1 0 17 874 0 1 4 0.128 1 0 24 874 0 1 4 0.128 1 0 30 874 0 1 4 0.128 1 0 10 875 0 1 4 0.128 1 0 17 875 0 1 4 0.128 1 0 24 875 0 1 4 0.128 1 0 30 875 0 1 4 0.128 1 0 10 876 0 1 4 0.128 1 0 17 876 0 1 4 0.128 1 0 24 876 0 1 4 0.128 1 0 30 876 0 1 4 0.1 28 1 0 10 877 0 1 4 0.128 1 0 17 877 0 1 4 0.128 1 0 24 877 0 1 4 0.128 1 0 30 877 0 1 4 0.128 1 0 10 878 0 1 4 0.128 1 0 17 878 0 1 4 0.128 1 0 24 878 0 1 4 0.128 1 0 30 878 0 1 4 0.128 1 0 10 879 0 1 4 0.128 1 0 17 879 0 1 4 0.128 1 0 24 879 0 1 4 0.128 1 0 30 879 0 1 4 0.128 1 0 10 880 0 1 4 0.128 1 0 17 880 0 1 4 0.128 1 0 24 880 0 1 4 0.128 1 0 30 880 0 1 4 0.128 1 0 10 881 0 1 4 0.128 1 0 17 881 0 1 4 0.128 1 0 24 881 0 1 4 0.128 1 0 30 881 0 1 4 0.128 1 0 10 882 0 1 4 0.128 1 0 17 882 0 1 4 0.128 1 0 24 882 0 1 4 0.128 1 0 30 882 0 1 4 0.128 1 0 10 883 0 1 4 0.128 1 0 17 883 0 1 4 0.128 1 0 24 883 0 1 4 0.128 1 0 30 883 0 1 4 0.128 1 0 10 884 0 1 4 0.1 28 1 0 17 884 0 1 4 0.128 1 0 24 884 0 1 4 0.128 1 0 30 884 0 1 4 0.128 1 0 10 885 0 1 4 0.128 1 0 17 885 0 1 4 0.128 1 0 24 885 0 1 4 0.128 1 0 30 885 0 1 4 0.128 1 0 10 886 0 1 4 0.128 1 0 17 886 0 1 4 0.128 1 0 24 886 0 1 4 0.128 1 0 30 886 0 1 4 0.128 1 0 10 887 0 1 4 0.128 1 0 17 887 0 1 4 0.128 1 0 24 887 0 1 4 0.128 1 0 30 887 0 1 4 0.128 1 0 10 888 0 1 4 0.128 1 0 17 888 0 1 4 0.128 1 0 24 888 0 1 4 0.128 1 0 30 888 0 1 4 0.128 1 0 10 889 0 1 4 0.128 1 0 17 889 0 1 4 0.128 1 0 24 889 0 1 4 0.128 1 0 30 889 0 1 4 0.128 1 0 10 890 0 1 4 0.128 1 0 17 890 0 1 4 0.128 1 0

### 20 24 890 0 1 4 0.128 1 0 30 890 0 1 4 0.128 1 0 ***Record 17

0 1 0 ***Record 19 Place Holder ***Record 20 1000 0 0 0 0 0 2 1 1 0 ***Record 26

0 0 0 ***Record 27

3 0.1 0.7 4.0 ***Record 31 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.97 10.0 ***Record 32 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 5.6 ***Record 32A 2.00 25.0 ***Record 33

8 *** Record 34,36,37 Horizon 1

1 10 1.63 0.088 0 0 0 9.62E - 059.62E - 05 0

1 0.0 88 0.034 0.46 1.4812 5.6 95 2.3 0 0 *** Record 34,36,37 Horizon 2

2 10 1.63 0.088 0 0 0 9.09E - 059.09E - 05 0

5 0.088 0.034 0.46 1.4812 5.6 95 2.3 0 0 *** Record 34,36,37 Horizon 3

3 20 1.68 0.079 0 0 0 7.49E - 057.49E - 05 0 20 0.079 0.025 0.14 0.4508 5.6 96 2.5 0 0 *** Record 34,36,37 Horizon 4

4 20 1.68 0.079 0 0 0 5.35E - 055.35E - 05 0 20 0.079 0.025 0.09 0.2898 5.6 96 2.5 0 0 *** Record 34,36,37 Horizon 5

5 20 1.59 0.068 0 0 0 3.21E - 053.21E - 05 0 20 0.068 0.016 0.09 0.2898 5.6 97 1.7 0 0 *** Record 34,36,37 Horizon 6

6 20 1.59 0.068 0 0 0 1.07E - 051.07E - 05 0 20 0.068 0.016 0.08 0.2576 5.6 97 1.7 0 0 *** Record 34,36,37 Horizon 7

7 800 1.59 0.068 0 0 0

0 0 0 50 0.068 0.016 0.07 0.2254 5.6 97 1.7 0 0 *** Record 34,36,37 Horizon 8

8 100 1.59 0.396 0 0 0

0 0 0 50 0.396 0.001 0.07 0.2254 5.6 97 1.7 0 0 *** Record 40

0 *** Record 42

YEAR 10 YEAR 10 YEAR 10 0 *** Record 45

3 YEAR *** Record 46 DCON1 TAVE 33 3 4 1.0E3 INFL TCUM 33 33 0.00233 IRRG TSER

### 21

**SCI -**  **GROW OUTPUT** SCIGROW VERSION 2.3 ENVIRONMENTAL FATE AND EFFECTS DIVISION OFFICE OF PESTICIDE PROGRAMS U.S. ENVIRONMENTAL PROTECTION AGENCY

SCREENING MODEL FOR AQUATIC PESTICIDE EXPOSURE SciGrow version 2.3 chemical:flutriafol time is 3/12/2014 8:31:22

-------------------------------------------- ---------------------------- Application Number of Total Use Koc Soil Aerobic rate (lb/acre) applications (lb/acre/yr) (ml/g) metabolism (days)

------------------------------------------------------------------------ 0.4 88 1.0 0.488 1.40E+02 4047.6

------------------------------------------------------------------------ groundwater screening cond (ppb) = 1.02E+01 ************************************************************************

### 22

**Appendix 3 Surface Water FIRST OUTPUT 4 applications @ 0.114 lb ai/A; 7 day interval**  RUN No. 1 FOR flutriafol ON 4 apps * INPUT VALUES *

-------------------------------------------------------------------- RATE (#/AC) No.APPS & SOIL SOLUBIL APPL TYPE %CROPPED INCORP ONE(MULT) INTERVAL Koc (PPM ) (%DRIFT) AREA (IN)

-------------------------------------------------------------------- 0.114( 0.456) 4 7 322.0 130.0 AERIAL(16.0) 91.0 0.0 FIELD AND RESERVOIR HALFLIFE VALUES (DAYS)

-------------------------------------------------------------------- METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED (FIELD) RAIN/RUNOFF (RESERVOI R) (RES. - EFF) (RESER.) (RESER.)

-------------------------------------------------------------------- 7202.00 2 0.00 0.00 - 0.00 49.20 49.20 UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.1 MAR 26, 2008

-------------------------------------------------------------------- PEAK DAY (ACUTE) ANNUAL AVERAGE (CHRONIC) CONCENTRATION CONCENTRATION

--------------------------------------------------------- -----------

28.169 2.803 **2 applications @ 0.114 lb ai/A; 7 day interval** RUN No. 2 FOR flutriafol ON grain sorg * INPUT VALUES *

-------------------------------------------------------------------- RATE (#/AC) No.APPS & SOIL SOLUBIL APPL TYPE %CROPPED INCORP ONE(MULT) INTERVAL Koc (PPM ) (%DRIFT) AREA (IN)

-------------------------------------------------------------------- 0.114( 0.228) 2 7 322.0 130.0 AERIAL(16.0) 91.0 0.0 FIELD AND RESERVOIR HALFLIFE VALUES (DAYS)

-------------------------------------------------------------------- METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED (FIELD) RAIN/RUNOFF (RESERVOIR ) (RES. - EFF) (RESER.) (RESER.)

-------------------------------------------------------------------- 7202.00 2 N/A 0.00
- 0.00 49.20 49.20 UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.1 MAR 26, 2008

-------------------------------------------------------------------- PEAK DAY (ACUTE) ANNUAL AVERAGE (CHRONIC) CONCENTRATION CONCENTRATION

--------------------------------------------------------- -----------

14.198 1.415

### 23

**1 application @ 0.26 lb ai/A T -**  **Band application** RUN No. 3 FOR flutrial ON cotton t
- b * INPUT VALUES *

-------------------------------------------------------------------- RATE (#/AC) No.APPS & SOIL SOLUBIL APPL TYPE %CROPPED INCORP ONE(MULT) INTERVAL Koc (PPM ) (%DRIFT) AREA (IN)

-------------------------------------------------------------------- 0.260( 0.260) 1 1 322.0 130.0 GROUND( 6.4) 91.0 1.5 FIELD AND RESERVOIR HALFLIFE VALUES (DAYS)

-------------------------------------------------------------------- METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED (FIELD) RAIN/RUNOFF (RESERVOI R) (RES. - EFF) (RESER.) (RESER.)

-------------------------------------------------------------------- 7202.00 2 N/A 0.00
- 0.00 49.20 49.20 UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.1 MAR 26, 2008

-------------------------------------------------------------------- PEAK DAY (ACUTE) ANNUAL AVERAGE (CHRONIC) CONCENTRATION CONCENTRATION

--------------------------------------------------------- -----------

10.885 1.078