|   | A. | Landlord and Tenant entered into that certain Standard Industrial Net Lease dated May 23, 2008, as amended by that certain First Amendment to Standard Industrial Net Lease dated May 6, 2010 (the “Lease”) for the premises described as Suites 20 and 21, containing 4,940 rentable square feet (the “Premises”), located at 11588 Sorrento Valley Road, San Diego, California, 92121 (the “Building”). |
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|   | B. | By this Second Amendment, Landlord and Tenant desire to expand the Premises to add Suite 19A, containing approximately 1,015 rentable square feet, located at 11588 Sorrento Valley Road, San Diego, California, 92121, and to otherwise modify the Lease as provided herein. |
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|   | C. | Capitalized terms not otherwise defined herein shall have the meanings ascribed to them in the Lease. |
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|  Lease Term  |   | Rent for Suite 19A |   | Rent for Suite 20 & 21(per existing lease) |                         | Total  |
|-------------------|--------|-----------------------------------|--------|-------------------------------------------------------------------------|------------------------------|--------|
| 01/01/13-07/31/13 |   | $                                 |   |                                                                    | 1,776.25 per month |   | $ |   |   | 8,645.00 per month |   | $ |   |   | 10,421.25 per month |
| 08/01/13-07/31/14 |   | $                                 |   |                                                                    | 1,827.00 per month           |   | $ |   |   | 8,892.00 per month |   | $ |   |   | 10,719.00 per month |
| 08/01/14-07/31/15 |   | $                                 |   |                                                                    | 1,877.75 per month           |   | $ |   |   | 9,139.00 per month |   | $ |   |   | 11,016.75 per month |

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| LANDLORD:                                         |   |
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| SORRENTO SQUARE, a California limited partnership |   |
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| By:                                               |   | CDC Financial Investors GP I, LLC,a Delaware limited liability company |   |
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|                                              |   | By: |   | CDC Financial Investors, LLC, |   |
|                                              |   |   |   | a Delaware limited liability company, its Manager |   |
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|                                              |   | By: |   | Collins Development Company, Inc., |   |
|                                              |   |   |   | a California S corporation, its Manager |   |
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| TENANT:                                           |   |
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| MABVAX THERAPEUTICS, INC., a Delaware corporation |   |
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