Page 1 of 4 **UNITED STA**

**TES ENVIRONMENTA L PROTECTION A** **GENCY WA** **SHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND** 

**POLLUTION PREVENTION**

**MEMORANDUM Date:**  February

10, 2015 **SUBJECT:** Acequinocyl : Tier I Review of Human Incidents **PC Code**  : 006329 **DP Barcode:** D 425575 **Decision No.:** 497720 **Registration No.:** NA **Petition No.:** NA **Regulatory Action:** NA **Risk Assessment Type:** NA **Case No.:** NA **TXR No.:** NA **CAS No .:**  57960
- 19
- 7 **MRID No.:** NA **40 CFR:** NA Ver.Apr.08 **FROM:** Shanna Recore, Industrial Hy gienist Toxicology

and Epidemiology Branch Health Effect Division (7509P) and Elizabeth Evans, Environmental Protection Specialist Toxicology

and Epidemiology Branch Health Effect s Division (7509P) **THROUGH:** David Miller, Acting Branch Chief

Toxicology

and Epidemiology Branch Health Effects Division (7509P) **TO:** Sarah Lev y , Risk Assessor

Risk Assessment Branch I Health Effects Division (7509P ) and Bonnie Adler , Chemical Review Manager Risk Management & Implementation Branch 5 Pesticide Re
- evaluation Division (7508P) Summary and Conclusions Because there were no incident cases reported for acequinocyl to either IDS or SENSOR
Pesticides, there does not appear to be a concern at this time that would warrant further investigation. The Agency will continue to monitor the incident information and if a concern is triggered, additional analysis will be included in the risk assessment.Page 2 of 4

Detailed Review **I. ACTION REQUESTED**  This review is intended to fulfill our requirement to docket summaries of incident data that were reported to the Agency , as wel l as to ensure human incident data and the Agricultural Health Study (AHS) are part of the problem formulation phase of registration review. Reports of adverse health effects allegedl y due to a specific pesticide exposure ( i.e. , an “incident”) are largel y self

- reported and therefore, generall y speaking, neither exposure to a pesticide or reported s ymptom (or the connection between the two) is validated or otherwise confirmed
. Ty pically , causation cannot be determined based on incident data. However, incid ent information can be an important source of feedback to the Agency : incidents of severe outcome, or a suggested pattern or trend among less severe incidents , can signal the Agency to further investigate a particular chemical or product. Observational ep idemiology studies relate the risk of disease, e.g. , cancer, and exposure to an agent such as a pesticide product in the general population or specific sub
- groups like pesticide applicators. **II. BACKGROUND**  Acequinocyl is a quinoline
- ty pe miticide that is currentl y registered for the use in the U.S. on a number of raw agricultural commodities (RACs) for the control of various phytophagous mite species. Acequinocy l is also registered for use in/on greenhouses , shadehouses, ornamental, floral, foliage, nursery

crops, landscape ornamentals in and around residences, businesses, public propert y, schools, interiorscapes, and other non
- production areas b y commercial applicators and homeowners. For this evaluation , both the OPP Incident Data Sy stem (IDS) and the Centers for Disease Control and Prevention/National Institute for Occupational Safet y and Health (CDC/NI OSH) Sentinel Event Notification Sy stem for Occupational Risk
- Pesticides (SENSOR) databases were consu lted for pesticide incident data on the active ingredient acequinocyl (pc code: 006329 ). The purpose of the database search is to identify potential patterns in the frequency and severity of the health effects attributed to acequinocy l exposure. Acequinocy l is not included in the AHS, and therefore this study

does not provide information for this report. **III. RESULTS/DISCUSSION** 
**a. IDS (Incident Data System)**  OPP’s I DS includes reports of alleged human health incidents from various sources, including man datory

Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) Section 6(a)(2) reports from registrants, other federal and state health and environmental agencies, and individual consumers. Since 1992, OPP has compiled these reports in IDS. IDS contain s reports from across the U.S. and most incidents have all relevant product information recorded. Reports submitted to the I DS represent anecdotal reports or allegations only , unless otherwise stated in the report.Page 3 of 4

IDS records incidents in one of two mo dules: Main IDS and Aggregate IDS:

o Main IDS contains incidents resulting in higher severit y outcomes and provides more detail with regard to case specifics. This s ystem stores incident data for death, major and moderate incidents, and it includes infor mation about the location, date and nature of the incident. Main IDS incidents involving only one active ingredient (as opposed to pesticide products with multiple active ingredients) are considered to provide more certain information about the potential effects of exposure from the pesticide.
o Aggregate IDS contains incidents resulting in less severe human incidents (minor, unknown, or no effects outcomes). These are reported by registrants onl y as counts in what are aggregate summaries. For the M ain I DS, from January 1, 2010 to December 30 , 2014, there were no incidents reported involving acequinocyl
. In Aggregate IDS, from January 1, 2010 to December 30 , 2014 , there were no incidents reported involving acequinocyl
.

**b. SENSOR** **- Pesticides**  The SENSOR
- Pesticides database covers 1 2 states from 1998
- 2011 , although reporting varies from state to state. Cases of pesticide
- related illnesses are ascertained from a variet y of sources, including: reports from local Poison Control Centers, state Department of Labor workers’ compensation claims when reported b y ph ys icians, reports from State Departments of Agriculture, and ph ys ician reports to state Departments of Health. Although both occupational and non
- occupational incidents are included in the database , SENSOR
- Pesticides focuses on occupational pesticide incidents, and is of particular value in providing that information. The state coordinator at each of the 1 2 respective state Departments of Health conducts case follow
up activities such as obtaining medical records to verify s ymptoms and severity . Using standardized protocol and case definitions derived from poison center reporting, the state SENSOR
- Pesticide coordinator enters the incident information into the state
- based s ys tem which is sent to NI O SH annually to be aggregated. A revie w of SENSOR
- Pesticides 1998
- 2011 identifies no cases involving acequinocy l (pc code 006329 )
. **c. Agricultural Health Study (AHS)**  The AHS is a high quality , prospective epidemiology study evaluating the link between pesti cide use and various health outcomes including cancer. The AHS includes private and commercial pesticide applicators and their spouses . If there are AHS findings relevant to a particular pesticide going through registration review, the Agency will ensure they are considered in the problem formulation/scoping phase of the process and, if appropriate, full y reviewed in the risk assessment phase of the process
. The AHS includes information on use of 8 0 different pesticide active ingredients commonly used in a griculture. Acequinocyl is not included in the AHS, and therefore this study

does not provide information for this report.Page 4 of 4

**IV. CONCLUSION**  Because there were no incident cases reported for acequinocy l to either IDS or SENSOR
Pesticides, there does not appear to be a concern at this time that would warrant further investigation. The Agency will continue to monitor the incident information and if a concern is triggered, additional analysis will be included in the risk assessment.