DRAFT

Testing of Certain High Production Volume 

Chemicals; Fourth Group of Chemicals

(Exposure Findings Supporting Information)

U.S. Environmental Protection Agency

Office of Pollution Prevention and Toxics 

Economics, Exposure and Technology Division 

May 2011
i

Table of Contents

PREFACE

1.0 DATA SOURCE DESCRIPTIONS ...........................................................................................................3

2.0 SUMMARY OF HPV4 CHEMICALS AND FINDINGS...............................................................................4
ii

Preface

This findings document was prepared to support EPA’s Proposed TSCA Section 4 Test Rule for Certain 

High Production Volume Chemicals; Fourth Group of Chemicals. Prior to promulgating a test rule under section 4 

of the Toxic Substances Control Act (TSCA), 15 U.S.C. §§2601 et seq, EPA is required to make certain findings 

identified in section 4(a) of TSCA relating to the chemical’s risk and potential exposure, the sufficiency of data to 

allow EPA to determine the human health or environmental effects of the chemical, and the need to conduct testing.

Under TSCA section 4(a)(1)(B), EPA must make the following findings to support a test rule based on 

concerns for exposure: (1) that a chemical substance is or will be produced in substantial quantities and that it enters 

or may reasonably be anticipated to enter the environment in substantial quantities and/or that there is or may be 

substantial and/or significant human exposure to such substance; (2) that there are insufficient data and experience 

upon which the effects of the manufacture, distribution in commerce, processing, use or disposal of such substance 

or mixture or of any combination of such activities on health or the environment can reasonably be determined or 

predicted; and (3) that testing of the substance or mixture with respect to such effects is necessary to develop such 

data. The criteria and standards used by EPA for evaluating the terms “substantial production,” “substantial 

release,” and “substantial or significant human exposure” as used in TSCA section 4(a)(1)(B)(i) are explained in 

EPA’s Final Statement of Policy; Criteria for Evaluating Substantial Production, Substantial Release, and 

Substantial or Significant Human Exposure set forth at 58 FR 28736 (May 14, 1993) (hereinafter referred to as the 

“B Policy”).

This document provides a detailed discussion of EPA’s evaluation of each of the chemical substances 

identified in the proposed test rule to determine that preliminary TSCA section 4(a)(1)(B) findings concerning 

“substantial production,” “substantial release,” and “substantial or significant human exposure” can be made. 
3

1.0 DATA SOURCE DESCRIPTIONS

TSCA Inventory Update Reporting Rule: In 1986, EPA promulgated the Inventory Update 

Reporting (IUR) regulations, under TSCA section 8(a), to facilitate the periodic updating of the 

TSCA Inventory database and to otherwise support activities associated with implementing 

TSCA. As originally promulgated, the IUR required chemical manufacturers (including 

importers) to report to EPA every 4 years the identity of chemical substances manufactured 

(including imported) annually in quantities of 10,000 pounds or more at each plant site they

owned or controlled. In 2003, EPA adjusted the universe of chemicals and plant sites that are 

required to report, and the type of information reported. In 2005, EPA changed the reporting 

frequency to once every 5 years, revised the manner in which amounts of a chemical substance 

manufactured or imported must be reported, and changed the submission period for reporting 

after 2006.

To protect the claims of confidential business information (CBI) asserted by some IUR submitters on the amount of 

the chemical substance manufactured (including imported) at a specific site, all production volumes reported by IUR 

submitters (i.e., CBI and non-CBI) for each chemical are combined by EPA for an aggregate total. Confidential 

business information claims are further protected by using eight ranges to identify the total for any specific chemical 

and then making available to the public the range that corresponds to the aggregate production volume. Publiclyavailable information from the 1986, 1990, 1994, 1998, and 2002 (and 2006) IUR reporting cycles are available online at: http://www.epa.gov/oppt/iur/index.htm

The Toxics Release Inventory (TRI) contains information about releases of certain chemicals and management of 

wastes at a wide variety of sources, including manufacturing operations, certain service businesses, and federal 

facilities. Publicly-available information from the 2008 TRI reporting cycle is available on-line at: 

http://www.epa.gov/triexplorer/

The National Library of Medicine Household Products Database provides information on the chemical 

ingredients and their percentage in specific brands of household products. Information in the database is from a 

variety of publicly available sources including brand-specific labels and Material Safety Data Sheets when available 

from manufacturers and manufacturers' web sites. Publicly-available information from the database is available online at: http://householdproducts.nlm.nih.gov/
4

2.0 SUMMARY OF HPV4 CHEMICALS AND FINDINGS

Table 2-1 below presents a summary of the high production volume (HPV) chemicals and data collected to support an exposure-based finding. Table 2-2 presents a chemical-by-chemical explanation of the supporting 

findings information.

Table 2-1 

Summary of Data Searched for Exposure Based Findings

CAS# Chemical Name

2006 IUR 

Production 

Volume

[Million 

lbs]

PAIR 

Production 

Volume

[Million 

lbs]

2006 IUR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

PAIR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

NLM Household 

Chemicals 

Database 

Non-CBI 2006 

IUR 

Commercial/ 

Consumer 

Code 

Description

PAIR -

Substantial 

Human 

Exposure 

(Consumer 

Use 

Indicated)

PAIR -

Substantial 

Release 

Criteria 

(>1 million 

lbs) Met 

2008 TRI 

Data(Total Onand Off-site 

Disposal or 

Other Releases, 

lbs)

Meet 

Exposure 

Based 

Criteria

for 

Workers

Meet 

Exposure 

Based 

Criteria 

for 

Consumers

Meet 

Exposure 

Based 

Criteria 

for 

Release

1 56-40-6 Glycine 1 < 10 - Yes -

25 personal care 

products C20 - Other - - - Yes Yes No

2 67-72-1

Ethane, 1,1,1,2,2,2-

hexachloro1 < 10 - Yes - - - - -

1,031 lbs 

released onsite;

288,418 lbs 

released offsite;

Yes No No

3 78-00-2 Plumbane, tetraethyl- 1 < 10 - No - -

C10 -

Lubricants, 

greases and fuel 

additives

- - - No Yes No

4 95-14-7 1H-Benzotriazole 1 < 10 - No -

4 inside-the-home 

products

C10 -Lubricants, 

greases, and 

fuel additives;

C11 - Metal 

products;

C20 - Other

- - - No Yes No

5 118-48-9

2H-3,1-Benzoxazine2,4(1H)-dione 10 < 50 - No - -

C2 -

Agricultural 

products (nonpesticidal); 

C20 - Other

- - - No Yes No

6 128-44-9

1,2-Benzisothiazol3(2H)-one, 1,1-dioxide, 

sodium salt (1:1)

1 < 10 - No -

132 personal care 

products C20 - Other - - - No Yes No

7 928-72-3

Glycine, N-

(carboxymethyl)-, 

sodium salt (1:2)

500 < 

1,000 CBI Yes CBI - - CBI CBI - Yes CBI CBI
Table 2-1 (Continued)

 

5

CAS# Chemical Name

2006 IUR 

Production 

Volume

[Million 

lbs]

PAIR 

Production 

Volume

[Million 

lbs]

2006 IUR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

PAIR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

NLM Household 

Chemicals 

Database 

Non-CBI 2006 

IUR 

Commercial/ 

Consumer 

Code 

Description

PAIR -

Substantial 

Human 

Exposure 

(Consumer 

Use 

Indicated)

PAIR -

Substantial 

Release 

Criteria 

(>1 million 

lbs) Met 

2008 TRI 

Data(Total Onand Off-site 

Disposal or 

Other Releases, 

lbs)

Meet 

Exposure 

Based 

Criteria

for 

Workers

Meet 

Exposure 

Based 

Criteria 

for 

Consumers

Meet 

Exposure 

Based 

Criteria 

for 

Release

8

1809-19-

4

Phosphonic acid, dibutyl 

ester

1 < 10 - Yes - - CBI - - - Yes CBI No

9

25377-

73-5

2,5-Furandione, 3-

(dodecen-1-yl)dihydro1 < 10 - No - - C20 - Other - - - No Yes No

10 26544-

38-7

2,5-Furandione, dihydro3-(tetrapropenyl)-

1 < 10 - No - -

C10 -

Lubricants, 

greases and fuel 

additives; C12 -

Paints and 

coatings; NRO

- - - No Yes No

11 27859-

58-1

Butanedioic acid, 2-

(tetrapropenyl)-

1 < 10 - Yes - -

C10 -

Lubricants, 

greases and fuel 

additives

- - - Yes Yes No

12 28777-

98-2

2,5-Furandione, dihydro3-(octadecen-1-yl)-

10 < 50 - No - -

C13 - Paper 

Products - - - No Yes No

13 29385-

43-1

1H-Benzotriazole, 6(or 

7)-methyl1 < 10 - No - -

C10 -

Lubricants, 

greases and fuel 

additives

- - - No Yes No

14 32072-

96-1

2,5-Furandione, 3-

(hexadecen-1-yl)dihydro50 < 100 - Yes - -

C13 - Paper 

products - - - Yes Yes No

15 61789-

73-9

Quaternary ammonium 

compounds, 

benzylbis(hydrogenated 

tallow alkyl)methyl, 

chlorides

1 < 10 - No - - CBI - - - No CBI No

16 64665-

57-2

1H-Benzotriazole, 6(or 

7)-methyl-, sodium salt 1 < 10 - No - - C20 - Other - - - No Yes No

17 68131-

13-5

Naphthenic acids, 

reaction products with 

diethylenetriamine

1 < 10 - Yes -

1 product used 

inside the home, 

in arts & crafts, 

or in home offices 

- - - Yes Yes No

18 68153-

60-6

Fatty acids, tall-oil, 

reaction products with 

diethylenetriamine, 

acetates

1 < 10 CBI Yes CBI - - CBI CBI - Yes CBI CBI
Table 2-1 (Continued)

 

6

CAS# Chemical Name

2006 IUR 

Production 

Volume

[Million 

lbs]

PAIR 

Production 

Volume

[Million 

lbs]

2006 IUR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

PAIR -

Substantial 

Human 

Exposure 

(>1,000 

Workers) 

Met

NLM Household 

Chemicals 

Database 

Non-CBI 2006 

IUR 

Commercial/ 

Consumer 

Code 

Description

PAIR -

Substantial 

Human 

Exposure 

(Consumer 

Use 

Indicated)

PAIR -

Substantial 

Release 

Criteria 

(>1 million 

lbs) Met 

2008 TRI 

Data(Total Onand Off-site 

Disposal or 

Other Releases, 

lbs)

Meet 

Exposure 

Based 

Criteria

for 

Workers

Meet 

Exposure 

Based 

Criteria 

for 

Consumers

Meet 

Exposure 

Based 

Criteria 

for 

Release

19 68424-

85-1

Quaternary ammonium 

compounds, benzyl-C12-

16-

alkyldimethyl,chlorides

1 < 10 - Yes -

3 auto products, 

28 home products, 

2 personal care 

products

C20 - Other - - - Yes Yes No

20 68442-

77-3

2-Butenediamide, (2E)-, 

N1,N4-bis[2-(4,5-

dihydro-2-nortall-oil 

alkyl-1H-imidazol-1-

yl)ethyl] derivs.

1 < 10 CBI Yes CBI - - CBI CBI - Yes CBI CBI

21 68607-

28-3

Quaternary ammonium 

compounds, (oxydi-2,1-

ethanediyl)bis[coco 

alkyldimethyl, 

dichlorides

1 < 10 - Yes - - C20 - Other - - - Yes Yes No

22 68909-

18-2

Pyridinium, 1-

(phenylmethyl)-, Et Me 

derivs., chlorides

1 < 10 - Yes - - C20 - Other - - - Yes Yes No

23 69834-

17-9

Benzene, decylphenoxy- 1 < 10 - No - -

C17 - Soaps and 

detergents - - - No Yes No

*

 “-“ indicates no information available. 

** “CBI” indicates information is available; however it is claimed as CBI. This information is provided in a separate CBI attachment.
Table 2-2

Chemical-by-Chemical Explanation of Findings 

CAS# Chemical Name Summary of Findings

1 56-40-6 Glycine

The total number of potentially exposed workers is likely to 

exceed 1,000 based on reported IUR data.

The NLM database indicates this chemical is used as an 

ingredient in 25 personal care products. Additionally, the IUR 

commercial/consumer product category C20 – Other 

(chemicals contained in commercial and consumer products 

not elsewhere classified) was reported for this chemical. This 

indicates that this chemical is present in an unknown number of 

commercial and consumer products that may potentially have a 

high number of exposures. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data

- Consumers potentially exceeding 10,000 people based on 

NLM data and IUR commercial/consumer product category 

(C20)

2 67-72-1

Ethane, 1,1,1,2,2,2-

hexachloroThe total number of potentially exposed workers is likely to 

exceed 1,000 based on reported IUR data.

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data

3 78-00-2 Plumbane, tetraethylThe IUR commercial/consumer product category C10 –

Lubricants, greases, and fuel additives was reported for this 

chemical. Chemicals reporting in this category are added to 

gasoline, kerosene, and distillate fuel oil after refining. They 

are additives in products used to enhance or clean combustion 

devices; it is expected that these products will be widely used 

by commercial workers and consumers and hence, may likely 

exceed 10,000 people. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C10)
CAS# Chemical Name Summary of Findings

4 95-14-7 1H-Benzotriazole

The NLM database indicates this chemical is used as an 

ingredient in 4 inside-the-home products. Additionally, the IUR 

commercial/consumer product categories C10 – Lubricants, 

greases, and fuel additives, C11 – Metal products, and C20 –

Other were reported for this chemical. Chemicals reporting in 

C10 are added to gasoline, kerosene, and distillate fuel oil after 

refining. Chemicals reporting in C11 are contained in metals 

and metallic substances contained in metal products for 

commercial and consumer use. Chemicals reporting in C20 are 

contained in commercial and consumer products not elsewhere 

specified. This indicates that this chemical is present in an 

unknown number of commercial and consumer products that 

may potentially have a high number of exposures. Based on 

these reporting categories, it is expected that this chemical will 

be contained in products that are widely used by commercial 

workers and consumers (including children) and hence, may 

likely exceed 10,000 people. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

NLM data and IUR commercial/consumer product categories

(C10, C11, and C20)

5 118-48-9

2H-3,1-Benzoxazine2,4(1H)-dione

The IUR commercial/consumer product category C2 –

Agricultural products (non-pesticidal) and C20 – Other 

(chemicals contained in commercial and consumer products 

not elsewhere classified) were reported for this chemical. 

Chemicals reporting in C2 are used to increase the productivity 

and quality of farm products. An example for this chemical 

would be use as a soil conditioner. Chemicals reporting in C20 

are present in an unknown number of commercial and 

consumer products that may potentially have a high number of

exposures. It is possible that products containing this chemical 

are used widely by more than 10,000 commercial workers and 

consumers. Based on this information, this chemical would 

meet the exposure based findings criteria of “substantial or 

significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C2, C20)
CAS# Chemical Name Summary of Findings

6 128-44-9

1,2-Benzisothiazol-3(2H)-

one, 1,1-dioxide, sodium 

salt (1:1)

The NLM database indicates this chemical is used as an 

ingredient in 132 personal care products. Additionally, the IUR 

commercial/consumer product category C20 – Other 

(chemicals contained in commercial and consumer products 

not elsewhere classified) was reported for this chemical. This 

indicates that this chemical is present in an unknown number of 

commercial and consumer products that may potentially have a 

high number of exposures. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million

lb)

- Consumers potentially exceeding 10,000 people based on 

NLM data and IUR commercial/consumer product category 

(C20)

7 928-72-3

Glycine, N-

(carboxymethyl)-, sodium 

salt (1:2)

The total number of potentially exposed workers is likely to 

exceed 1,000 based on reported IUR data. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data

8 1809-19-4

Phosphonic acid, dibutyl 

ester

The total number of potentially exposed workers is likely to 

exceed 1,000 based on reported IUR data. 

The IUR commercial/consumer use information is claimed CBI 

for this chemical. The types of products containing this 

chemical are unknown but may be widely used by commercial 

workers and consumers and hence, may likely exceed 10,000 

people. Based on this information, this chemical would meet 

the exposure based findings criteria of "substantial or 

significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data 

- Consumers potentially exceeding 10,000 people based on an

IUR commercial/consumer product category whose identity is 

CBI.
CAS# Chemical Name Summary of Findings

9 25377-73-5

2,5-Furandione, 3-(dodecen1-yl)dihydroThe IUR commercial/consumer product category C20 – Other 

(chemicals contained in commercial and consumer products 

not elsewhere classified) was reported for this chemical. This 

indicates that this chemical is present in an unknown number of 

commercial and consumer products that may potentially have a 

high number of exposures. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C20)

10 26544-38-7

2,5-Furandione, dihydro-3-

(tetrapropenyl)-

The IUR commercial/consumer product categories C10 –

Lubricants, greases, and fuel additives, C12 – Paints and 

coatings, and NRO – Not readily obtainable were reported for 

this chemical. Chemicals reporting in C10 are added to 

gasoline, kerosene, and distillate fuel oil after refining. 

Chemicals reporting in C12 are contained in commercial and 

consumer paints, including artists’ paints, varnishes, lacquers, 

enamels and shellac, paint and varnish removers and cleaners. 

Chemicals reporting in NRO are potentially present in 

commercial or consumer products although such information is 

not available. Based on these reporting categories, it is 

expected that this chemical will be contained in products that 

are widely used by commercial workers and consumers and 

hence, may likely exceed 10,000 people. Based on this 

information, this chemical would meet the exposure based 

findings criteria of “substantial or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C10, 12, NRO)
CAS# Chemical Name Summary of Findings

11 27859-58-1

Butanedioic acid, 2-

(tetrapropenyl)-

The total number of potentially exposed workers is likely to 

exceed 1,000 based on reported IUR data. 

The IUR commercial/consumer product category C10 –

Lubricants, greases, and fuel additives was reported for this 

chemical. Chemicals reporting in this category are added to 

gasoline, kerosene, and distillate fuel oil after refining. They 

are additives in products used to enhance or clean combustion 

devices; it is expected that these products will be widely used 

by commercial workers and consumers and hence, may likely 

exceed 10,000 people. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C10)

12 28777-98-2

2,5-Furandione, dihydro-3-

(octadecen-1-yl)-

The IUR commercial/consumer product category C13 – Paper 

products was reported for this chemical. Chemicals reporting 

in this category are contained in commercial and consumer 

paper products. It is expected that paper products are widely 

used by commercial workers and consumers which may exceed 

10,000 people. Based on this information, this chemical would 

meet the exposure based findings criteria of “substantial or 

significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C13)

13 29385-43-1

1H-Benzotriazole, 6(or 7)-

methylThe IUR commercial/consumer product category C10 –

Lubricants, greases, and fuel additives was reported for this 

chemical. Chemicals reporting in this category are added to 

gasoline, kerosene, and distillate fuel oil after refining. They 

are additives in products used to enhance or clean combustion 

devices; it is expected that these products will be widely used 

by commercial workers and consumers and hence, may likely 

exceed 10,000 people. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C10)
CAS# Chemical Name Summary of Findings

14 32072-96-1

2,5-Furandione, 3-

(hexadecen-1-yl)dihydroThe total number of potentially exposed workers is likely to 

exceed 1,000 based on reported IUR data. 

The IUR commercial/consumer product category C13 – Paper 

products was reported for this chemical. Chemicals reporting 

in this category are contained in commercial and consumer 

paper products. It is expected that paper products are widely 

used by commercial workers and consumers which may exceed 

10,000 people. Based on this information, this chemical would 

meet the exposure based findings criteria of “substantial or 

significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (50 million - 100

million lb)

- Total workers exceeding 1,000 based on IUR data 

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C13)

15 61789-73-9

Quaternary ammonium 

compounds, 

benzylbis(hydrogenated 

tallow alkyl)methyl, 

chlorides

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Consumers potentially exceeding 10,000 people based on an

IUR commercial/consumer product category whose identity is 

CBI.

16 64665-57-2

1H-Benzotriazole, 6(or 7)-

methyl-, sodium salt

The IUR commercial/consumer product category C20 – Other 

(chemicals contained in commercial and consumer products 

not elsewhere classified) was reported for this chemical. This 

indicates that this chemical is present in an unknown number of 

commercial and consumer products that may potentially have a 

high number of exposures. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C20)

17 68131-13-5

Naphthenic acids, reaction 

products with 

diethylenetriamine

The total number of potentially exposed workers exceeds 1,000 

workers based on IUR data. 

The NLM database indicates this chemical is used as an 

ingredient in 1 product that is used inside the home, in arts and 

crafts, or in home offices.

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data 

- Consumers potentially exceeding 10,000 people based on 

NLM data
CAS# Chemical Name Summary of Findings

18 68153-60-6

Fatty acids, tall-oil, reaction 

products with 

diethylenetriamine, acetates

The total number of potentially exposed workers exceeds 1,000 

workers based on IUR data. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data 

19 68424-85-1

Quaternary ammonium 

compounds, benzyl-C12-16-

alkyldimethyl,chlorides

The total number of potentially exposed workers exceeds 1,000 

workers based on IUR data. 

The NLM database indicates this chemical is used as an 

ingredient in 3 automotive products, 28 home products, and 2

personal care products. Additionally, the IUR 

commercial/consumer product category C20 – Other 

(chemicals contained in commercial and consumer products 

not elsewhere classified) was reported for this chemical. This 

indicates that this chemical is present in an unknown number of 

commercial and consumer products that may potentially have a 

high number of exposures. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data

- Consumers potentially exceeding 10,000 people based on 

NLM data and IUR commercial/consumer product category 

(C20)

20 68442-77-3

2-Butenediamide, (2E)-, 

N1,N4-bis[2-(4,5-dihydro2-nortall-oil alkyl-1Himidazol-1-yl)ethyl] derivs.

The total number of potentially exposed workers exceeds 1,000 

workers based on IUR data.

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data 
CAS# Chemical Name Summary of Findings

21 68607-28-3

Quaternary ammonium 

compounds, (oxydi-2,1-

ethanediyl)bis[coco 

alkyldimethyl, dichlorides

The total number of potentially exposed workers exceeds 1,000 

workers based on IUR data.

The IUR commercial/consumer product category C20 – Other 

(chemicals contained in commercial and consumer products 

not elsewhere classified) was reported for this chemical. This 

indicates that this chemical is present in an unknown number of 

commercial and consumer products that may potentially have a 

high number of exposures. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C20)

22 68909-18-2

Pyridinium, 1-

(phenylmethyl)-, Et Me 

derivs., chlorides

The total number of potentially exposed workers exceeds 1,000 

workers based on IUR data.

The IUR commercial/consumer product category C20 – Other 

(chemicals contained in commercial and consumer products 

not elsewhere classified) was reported for this chemical. This 

indicates that this chemical is present in an unknown number of 

commercial and consumer products that may potentially have a 

high number of exposures. Based on this information, this 

chemical would meet the exposure based findings criteria of 

“substantial or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Total workers exceeding 1,000 based on IUR data

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C20)

23 69834-17-9 Benzene, decylphenoxyThe IUR commercial/consumer product category C17 – Soaps 

and detergents was reported for this chemical. Chemicals 

reporting in this category are contained in liquid, granulated, 

caked, and flaked washing detergents and personal soaps, 

dishwashing compounds, presoaks and scouring compounds for 

commercial and consumer use. It is expected that these 

products are widely used by commercial workers, consumers, 

and children, which may exceed 10,000 people. Based on this 

information, this chemical would meet the exposure based 

findings criteria of “substantial or significant human exposure.” 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million 

lb)

- Consumers potentially exceeding 10,000 people based on 

IUR commercial/consumer product category (C17)