### SAT Report PMN Number: P-08-0701 SAT Date: 9/19/2008 Print Date: 1/12/2010

Related cases : CBI : Yes Health related cases: Ecotox related cases:

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1-2 2

Persistence Bioaccum Toxicity Comments 3 1 2
Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Inhalation and drinking water. Ecotox: N o releases to water Fate: ;
Keywords : Keywords: ONCO, DEVEL, UNCERT-IMMUNO, BLOOD, ALGAL SHADING
Summary of Assessment :

Fate : Fate Summary: P-08-0701 FATE: Estimations for neutralized log Kow = 2.53 (E) log Koc = 2.58 (E) log Fish BCF = 0.50 (E) PMN Substance: Solid with MP = Dec. 345-405 EC (DSC) S = 47.4 mg/L at 25 EC (M) VP < 1.0E-6 torr at 25 EC (E) BP > 400 EC (E) H < 1.00E-8 (E) logKoc = -0.18 (M) POTW removal (%) = 0-50 via sorption; OECD111 (Hydrolysis): 1.7%( p H4)/0%( p H7)/1.8%( p H9)/6d; OECD301F (Mano Resp): 0-1%/28dN RB. Time for complete ultimate aerobic biodeg > mo Sorption to soils/sediments = moderate PBT Potential: P3B1 *CEB FATE: Migration to ground water = moderate

Health : Health Summary: Absorption of the intact compound is nil through the skin and GI tract and poor through the lungs based on physical/chemical properties. Expect dissociation of the salt in the stomach and in the intestine followed by absorption of the products based on analogs. There is a marginal concern for oncogenicity by analogy to (also known as - the

p roduced an increased incidence of sarcoma of the spleen and a dose -related increase in neoplastic nodules of the liver in male F344 rats at 3000 p pm in the diet The PMN compound is expected to be less of a concern for oncogenicity than the analog because the group on the will enhance excretion of the compound. There is concern for developmental toxicity and uncertain concern for immunotoxicity for the product. A concern for blood effects is also raised by analogy to based on the effects on the spleen and hemosiderosis at doses of 600 to 50,000 p pm in the diet. Low moderate concern. Test Data: negative in Salmonella and E coli - Prival modification negative in the mouse lymphoma assay acute oral study in rats - no deaths at 2000 mg/kg, slight sedation at 2 to 3 hours after dosing acute dermal study in rats - no deaths at 2000 mg/kg, red staining at site of application not a dermal sensitizer in the mouse local lymph node assay (10% concentration) 28-day oral study in rats (50, 250, 1000 mg/kg) - no adverse effects seen; N OAEL = 1000 mg/kg mild eye irritant mild skin irritant

Ecotox :

Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 >100 daphnid 48-h LC50 >100 green algal 96-h EC50 20 shading fish

_ chronic value >10 daphnid

_ chronic value >10 algal

_ chronic value 2.0 shading Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value

_ Ecotox Values Comments: Predictions are based on SAR-nearest analog method for and indirect effect of algal shading from the; SAR chemical class = ; MW 492; solid with decomposition prior to melting at 345 C (M); S < 200 mg/L at 20 C, p H 7 (P); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; DW hardness < 150.0 mg/L as CaCO3; and DW TOC < 2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 200

SARs SAR Class

Ecotox Factors Comments: See attachment immediately below for revised concern concentration based on test data below. S. Cragg

SAT Chair: Becky Jones