| x | ANNUAL      REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF      1934 |
|---|------------------------------------------------------------------------------------------------|

| ¨ | TRANSITION      REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF      1934 |
|--------|----------------------------------------------------------------------------------------------------|

| CYTOGEN      CORPORATION                                   |
|------------------------------------------------------------|
| (Exact      Name of Registrant as Specified in ItsCharter) |

|   | Delaware                                      |   | 22-2322400                                |   |
|--------|-----------------------------------------------|--------|-------------------------------------------|--------|
|   | (State      or Other Jurisdiction of          |   | (I.R.S.      Employer Identification No.) |   |
|   | Incorporation      or Organization)           |   |                                      |   |
|   |                                          |   |                                      |   |
|   | 650      College Road East, Suite 3100        |   |                                      |   |
|   | Princeton,      New Jersey                    |   | 08540                                     |   |
|   |                                          |   |                                      |   |
|   | (Address      of Principal Executive Offices) |   | (Zip      Code)                           |   |

| Registrant's      telephone number, including area code: | (609)      750-8200 |
|----------------------------------------------------------|---------------------|

|  Securities      registered pursuant to Section 12(b) of the Act: |  |
|------------------------------------------------------------------------|--|

|  Title      of Each Class               |   | Name      of Each Exchange onwhich      Registered |
|----------------------------------------------|--------|----------------------------------------------------|
| Common      Stock, $0.01 par value per share |   | The      NASDAQ                                    |
|                                         |   | Stock      Market LLC                              |

|   | Securities      registered pursuant to Section 12(g) of theAct: |
|--------|-----------------------------------------------------------------|

|   | Preferred      Stock Purchase Rights, $0.01 par value pershare |
|--------|----------------------------------------------------------------|

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| Large      Accelerated Filer ¨                                                  | Accelerated      Filer ¨    |
|--------------------------------------------------------------------------------------|----------------------------------|
| Non-      Accelerated Filer ¨(Do      not check if a smaller reporting company) | Smaller      Reporting Company x |

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TABLE OF CONTENTS

|                 |                                                                                                     |   | Page   |
|----------------------|----------------------------------------------------------------------------------------------------------|--------|--------|
|                 |                                                                                                     |   |   |
| PART      III        |                                                                                                     |   |   |
|   Item 10. | Directors,      Executive Officers and Corporate Governance                                              |   | 2      |
|                 |                                                                                                     |   |   |
|   Item 11. | Executive      Compensation                                                                              |   | 5      |
|                 |                                                                                                     |   |   |
|   Item 12. | Security      Ownership of Certain Beneficial Owners and Management and Related      Stockholder Matters |   | 19     |
|                 |                                                                                                     |   |   |
|   Item 13. | Certain      Relationships and Related Transactions and Director      Independence                       |   | 22     |
|                 |                                                                                                     |   |   |
|   Item 14. | Principal      Accounting Fees and Services                                                              |   | 22     |
|                 |                                                                                                     |   |   |
| PART      IV         |                                                                                                     |   |   |
|   Item 15  | Exhibits                                                                                                 |   | 24     |
|                 |                                                                                                     |   |   |
| Signatures           |                                                                                                     |   | 25     |

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Item 10.  Directors, Executive Officers and CorporateGovernance

| Name                                |   | Age    |   | Served as aDirector Since |   | Positions      withthe Company                  |
|-------------------------------------|--------|--------|--------|------------------------------------------|--------|------------------------------------------------------|
| James      A. Grigsby               |   | 65     |   | 1996                                     |   | Chairman      of the Board                           |
|                                |   |   |   |                                     |   |                                                 |
| John E. Bagalay, Jr. |   | 74     |   | 1995                                     |   | Director                                             |
|                                |   |   |   |                                     |   |                                                 |
| Allen      Bloom                    |   | 64     |   | 2003                                     |   | Director                                             |
|                                |   |   |   |                                     |   |                                                 |
| Stephen      K. Carter              |   | 70     |   | 1998                                     |   | Director                                             |
|                                |   |   |   |                                     |   |                                                 |
| Robert F. Hendrickson     |   | 75     |   | 1995                                     |   | Director                                             |
|                                |   |   |   |                                     |   |                                                 |
| Dennis      H. Langer               |   | 56     |   | 2005                                     |   | Director                                             |
|                                |   |   |   |                                     |   |                                                 |
| Kevin      G. Lokay                 |   | 51     |   | 2001                                     |   | President,      Chief Executive Officer and Director |
|                                |   |   |   |                                     |   |                                                 |
| Joseph      A. Mollica              |   | 67     |   | 2005                                     |   | Director                                             |

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| Name                      |   | Age    |   | Capacities      In Which Served                                                 |   | In      Current Position Since                                                                                                                                          |
|---------------------------|--------|--------|--------|---------------------------------------------------------------------------------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                      |   |   |   |                                                                            |   |                                                                                                                                                                    |
| Executive      Officers:  |   |   |   |                                                                            |   |                                                                                                                                                                    |
|                      |   |   |   |                                                                            |   |                                                                                                                                                                    |
| Kevin      G. Lokay(1)    |   | 51     |   | President, Chief ExecutiveOfficer      and Director                   |   | November      2007                                                                                                                                                      |
|                      |   |   |   |                                                                            |   |                                                                                                                                                                    |
| Kevin      J. Bratton     |   | 59     |   | Senior Vice President,      Finance, and Chief Financial Officer |   | November      2006                                                                                                                                                      |
|                      |   |   |   |                                                                            |   |                                                                                                                                                                    |
| William      F. Goeckeler |   | 52     |   | Senior      Vice President,Operations                                           |   | December      2003(Vice      President, Operations from January 2003 to December 2003; Vice President      of Research and Development from June 2001 to January  2003) |
|                      |   |   |   |                                                                            |   |                                                                                                                                                                    |
| Stephen      A. Ross      |   | 43     |   | Senior      Vice President Sales andMarketing                                   |   | July      2007                                                                                                                                                          |

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| (1) | Mr.      Lokay’s biographical information appears above.  See      “Information about our Board ofDirectors”. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------|

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Item 11.  ExecutiveCompensation

|   | · | Motivate,      recruit and retain executives capable of meeting the Company’s strategic      objectives and building long-term shareholder  value; |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | Provide      incentives to ensure superior executive performance and successful      financial results for the Company;and |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------|

|   | · | Align      the interests of executives with the long-term interests of      shareholders. |
|--------|--------|-------------------------------------------------------------------------------------------|

|   | The      Committee seeks to achieve these objectivesby: |
|--------|---------------------------------------------------------|

|   | · | Establishing      a compensation structure that is both market competitive and internally      fair; |
|--------|--------|------------------------------------------------------------------------------------------------------|

|   | · | Linking      a substantial portion of compensation to the Company’s achievement of      financial objectives and the individual’s contribution to the attainment      of those objectives; |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | Providing      risk for underachievement and rewards for overachievement of      goals; |
|--------|--------|-----------------------------------------------------------------------------------------|

|   | · | Encouraging      executives to manage the Company from the perspective of owners of the      Company; and |
|--------|--------|-----------------------------------------------------------------------------------------------------------|

|   | · | Providing      long-term equity-based incentives and encouraging direct share ownership      by executives. |
|--------|--------|-------------------------------------------------------------------------------------------------------------|

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|   | · | Base      salary; |
|--------|--------|-------------------|

|   | · | Annual      short-term cash incentives; |
|--------|--------|-----------------------------------------|

|   | · | Long-term      equity incentive awards; |
|--------|--------|-----------------------------------------|

|   | · | Special      benefits and perquisites; |
|--------|--------|----------------------------------------|

|   | · | Change      in control agreements; and |
|--------|--------|----------------------------------------|

|   | · | Retention      agreements. |
|--------|--------|----------------------------|

| Name                      |   | Title                        |   | 2007      Salary @ Year-End |   | 2008      Salary |   | %      Increase |
|---------------------------|--------|------------------------------|--------|-----------------------------|--------|------------------|--------|-----------------|
| Kevin      G. Lokay       |   | President      & CEO     |   | $400,000                    |   | $400,000         |   | --              |
| Kevin      J. Bratton     |   | SVP,      Finance & CFO  |   | $225,000                    |   | $238,500         |   | 6%              |
| William      F. Goeckeler |   | SVP      of Operations       |   | $277,156                    |   | $285,471         |   | 3%              |
| Stephen      A. Ross      |   | SVP      Sales and Marketing |   | $235,000                    |   | $244,400         |   | 4%              |

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| Name                      |   | Title                             |   | 2007      Target Bonus      ($)                                                          |   | 2007      Target Bonus      (% Salary) |   | 2007      Actual Bonus ($) |   | 2007      Actual Bonus (% Salary @ Year-End) |
|---------------------------|--------|-----------------------------------|--------|------------------------------------------------------------------------------------------|--------|----------------------------------------|--------|----------------------------|--------|----------------------------------------------|
| Kevin      G. Lokay       |   | President      & CEO          |   |                 $  33,333(2) |   | 50%                                    |   | --                         |   | --                                           |
| Michael      D. Becker    |   | President      & CEO(1)       |   |                 $191,860               |   | 50%                                    |   | --                         |   | --                                           |
| Kevin      J. Bratton     |   | SVP,      Finance & CFO       |   |                 $  67,500    |   | 30%                                    |   | --                         |   | --                                           |
| William      F. Goeckeler |   | SVP,      Operations              |   |                 $110,862               |   | 40%                                    |   | --                         |   | --                                           |
| William      J. Thomas    |   | SVP      & General Counsel(1) |   |                 $  76,016    |   | 30%                                    |   | --                         |   | --                                           |
| Stephen      A. Ross      |   | SVP,      Sales and Marketing     |   |                 $  41,125(3) |   | 35%                                    |   | --                         |   | --                                           |

|   | (1) | Resigned      in November 2007. |
|--------|-----|---------------------------------|

|   | (2) | Prorated      based on employment date in November2007. |
|--------|-----|---------------------------------------------------------|

|   | (3) | Prorated      based on employment date in July2007. |
|--------|-----|-----------------------------------------------------|

| Name                      |   | Title                             |   | 2007      Target Bonus ($) |   | 2007      Target  Bonus      (% Salary) |   | 2008      Target Bonus ($) |   | 2008      Target  Bonus (% Salary) |
|---------------------------|--------|-----------------------------------|--------|----------------------------|--------|---------------------------------------------------|--------|----------------------------|--------|----------------------------------------------|
| Kevin      G. Lokay       |   | President      & CEO          |   | $  33,333        |   | 50%                                               |   | $200,000                   |   | 50%                                          |
| Michael      D. Becker    |   | President      & CEO(1)       |   | $191,860                   |   | 50%                                               |   | --                         |   | --                                           |
| Kevin      J. Bratton     |   | SVP,      Finance & CFO       |   | $  67,500        |   | 30%                                               |   | $  71,550        |   | 30%                                          |
| William      F. Goeckeler |   | SVP,  Operations        |   | $110,862                   |   | 40%                                               |   | $114,189                   |   | 40%                                          |
| William      J. Thomas    |   | SVP      & General Counsel(1) |   | $  76,016        |   | 30%                                               |   | --                         |   | --                                           |
| Stephen      A. Ross      |   | SVP,      Sales and Marketing     |   | $  41,125        |   | 35%                                               |   | $  85,540        |   | 35%                                          |

|   | (1) | Resigned      in November 2007. |
|--------|-----|---------------------------------|

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| Nameand      PrincipalPosition                                                          | Year     | Salary($)      | Bonus($)(1)(2) | StockAwards($)(3) | OptionAwards($)(3) | Non-Equity      Incentive Plan Compensa-tion($) | Change      in Pension Value and Nonqualified Deferred Compensa-tion      Earnings ($) | AllOther      Compensation($)(1)(4) | Total($)       |
|-----------------------------------------------------------------------------------------|----------|----------------|----------------|-------------------|--------------------|-------------------------------------------------|----------------------------------------------------------------------------------------|-------------------------------------|----------------|
| (a)                                                                                     | (b)      | (c)            | (d)            | (e)               | (f)                | (g)                                             | (h)                                                                                    | (i)                                 | (j)            |
| Kevin      G. Lokay(5)President      and Chief Executive Officer                        | 2007     | 46,154         | --             | 10,953            | 28,146             | --                                              | --                                                                                     | 82                                  | 85,335         |
|                                                                                    |     |           |           |              |               |                                            |                                                                                   |                                |           |
| Michael      D. Becker(6)President      and Chief Executive Officer                     | 20072006 | 361,166321,423 | --181,000      | 115,36463,974     | 208,522422,662     | ----                                            | ----                                                                                   | 7,0906,893                          | 692,142995,952 |
|                                                                                    |     |           |           |              |               |                                            |                                                                                   |                                |           |
| Kevin      J. Bratton(7)Senior      Vice President, Finance and Chief Financial Officer | 20072006 | 225,00028,558  | --20,000       | 56,0106,375       | 95,1709,727        | ----                                            | ----                                                                                   | 7,566121                            | 383,74664,781  |
|                                                                                    |     |           |           |              |               |                                            |                                                                                   |                                |           |
| William      F. GoeckelerSenior      Vice President, Operations                         | 20072006 | 276,855229,007 | --91,664       | 63,84932,120      | 114,831132,369     | ----                                            | ----                                                                                   | 7,3777,093                          | 462,912492,253 |
|                                                                                    |     |           |           |              |               |                                            |                                                                                   |                                |           |
| William      J. Thomas(9)Senior      Vice President and General Counsel                 | 20072006 | 241,461221,032 | --66,338       | 42,86225,300      | 73,527107,418      | ----                                            | ----                                                                                   | 5,1454,207                          | 362,995424,295 |
|                                                                                    |     |           |           |              |               |                                            |                                                                                   |                                |           |
| Stephen      A. Ross(8)Senior      Vice President Sales and Marketing                   | 2007     | 103,943        | --             | 5,102             | 9,106              | --                                              | --                                                                                     | 30,535                              | 148,686        |
|                                                                                    |     |           |           |              |               |                                            |                                                                                   |                                |           |

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| (1) | Certain      perquisites or personal benefits are not included herein because they did      not exceed, in the case of each Named Executive, $10,000 in the      aggregate. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | The      amounts disclosed in this column include bonus payments made to certain of      the Named Executives in cash for fiscal year 2006 and paid in      2007. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | The      amounts in these columns do not reflect compensation actually received by      the named executive officers.  Instead, the amounts reflect the      compensation expense recognized by the Company in 2007 and 2006 for stock      awards and option awards, computed in accordance with FAS      123(R).  The compensation expense reflects stock awards and      option awards granted in and prior to 2007 and excludes any reduction in      value due to potential service-based forfeiture      assumptions.  Assumptions used in the calculation of the      compensation expense are included in footnote 13 to the Company’s audited      financial statements for each of the fiscal years ended December 31, 2007      and 2006, included in |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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|   | the      Company’s Annual Report on Form 10-K filed with the SEC on March 14,      2008.  The compensation expense does not correspond to the      actual value that may be realized by the named executive officers with      respect to these awards if and when they vest.  Messrs Becker      and Thomas resigned in November 2007 and all of their unvested RSAs and      options have been cancelled.  These forfeitures resulted in      reductions to the compensation expense above of $177,181 and $177,664 for      Mr. Becker and $66,345 and $55,660 for Mr.  Thomas. |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4) | The      amounts disclosed in this column include amounts contributed or accrued by      us in 2007 and 2006 under our Retirement Savings Plan, a defined      contribution plan which consists of a 401(k) contribution portion. In      fiscal year 2007, these amounts were as follows:  on behalf of      Mr. Lokay, $0; Mr. Becker, $6,750; Mr. Bratton, $6,633; Dr. Goeckeler,      $6,750; Mr. Thomas, $4,617 and Mr. Ross, $1,356.  In fiscal year      2006, these amounts were as follows: on behalf of Mr. Becker, $6,600; Mr.      Bratton, $0; Dr. Goeckeler, $6,600; and Mr. Thomas, $3,900. The amounts      disclosed also include insurance premiums paid by the Company with respect      to group term life insurance and with respect to fiscal years 2007 and      2006. In fiscal year 2007, these amounts were as follows:  on      behalf of Mr. Lokay, $82; Mr. Becker, $340; Mr. Bratton, $903; Dr.      Goeckeler, $627; Mr. Ross, $98; and Mr. Thomas, $528.  In fiscal      year 2006 they were as follows: on behalf of Mr. Becker, $293; Mr.      Bratton, $121; Dr. Goeckeler, $493; and Mr. Thomas, $307.  The      amounts disclosed in 2007 also include relocation reimbursement of $29,081      paid to Mr. Ross. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (5) | Mr.      Lokay joined the Company in November 2007 as President and Chief Executive      Officer.  Mr. Lokay received, in accordance with our 2006 Equity      Compensation Plan, as amended, a grant of (i) 350,877 restricted stock      units, or RSUs that vest upon the successful completion of a performance      milestone established by the compensation committee of the board of      directors and expire upon the triggering of the performance milestone      event in section (ii); and (ii) 175,439 RSUs that vest upon the successful      completion of another performance milestone established by the      compensation committee of the board of directors and expire upon the      triggering of the performance milestone event in section    (i). |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Mr.      Lokay also received grants of options as follows:  (i) options      to purchase 400,000 shares of the Company’s commons stock, in accordance      with the 2004 Stock Incentive Plan, as amended, at an exercise price equal      to the higher of the closing price of the Company’s common stock, as      listed on the NASDAQ Global Market on December 18, 2007 and $0.57 and      vesting at a rate of 25% on each anniversary of the date of grant; and      (ii) options to purchase 100,000 shares of the Company’s common stock, in      accordance with the 2006 Plan, as amended, at an exercise price equal to      the higher of the of closing price of the Company’s common stock, as      listed on the NASDAQ Global Market on December 18, 2007 and $0.57 and      vesting at a rate of 25% on each anniversary of the date of      grant. |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (6) | Mr.      Becker joined the Company in April 2001 and was promoted to President and      Chief Executive Officer in December 2002. In connection with such      promotion, Mr. Becker was granted options to purchase 200,000 shares of      our common stock under our 1995 Plan. The exercise price per share of such      options is $3.54, the fair market value of our common stock on the date of      grant. 50,000 of such options vested immediately upon grant, 50,000      options vested in 2006 upon the achievement of certain performance      milestones pre-established by the Board of Directors, and the remaining      100,000 options were cancelled upon Mr. Becker’s resignation in November      2007 in accordance with the terms of Mr. Becker’s option      agreements.  The grant date fair value of the performance      options vested in 2006 in the amount of $152,000 is included in the      “Option Awards” column. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (7) | Mr.      Bratton joined the Company in November 2006 as our Senior Vice President,      Finance and Chief FinancialOfficer. |
|-----|-----------------------------------------------------------------------------------------------------------------------------|

| (8) | Mr.      Ross joined the Company in July 2007 as our Senior Vice President Sales      and Marketing. |
|-----|------------------------------------------------------------------------------------------------------|

| (9) | Mr.      Thomas resigned in November 2007 as our Senior Vice President and General      Counsel. |
|-----|--------------------------------------------------------------------------------------------------|

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|                                                                                                                                                                |                                     |  Estimated      Future PayoutsUnder      Non-Equity IncentivePlan      Awards |      Estimated      Future Payouts Under Equity Incentive Plan Awards | All      OtherStockAwards:NumberofSharesof      Stockor      Units(#) | All      OtherOption      Awards:Number      ofSecuritiesUnder-lyingOptions(#) | Exerciseor      BasePrice      of OptionAwards($/Sh) | Grant      Date Fair Value of Equity Awards($) |
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------------|------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------|--------------------------------------------------------------------------------|------------------------------------------------------|------------------------------------------------|
|  Name                                                                                                                                                          | GrantDate                                | Threshold($)                                                                       | Target($)                                                                                      | Maximum($)                                                            | Threshold(#)                                                                   | Target(#)                                            | Maximum      (#)                               |
| (a)                                                                                                                                                                 | (b)                                      | (c)                                                                                | (d)                                                                                            | (e)                                                                   | (f)                                                                            | (g)                                                  | (h)                                            | (i) | (j) | (k) | (l) |
| Michael      D. Becker                                                                                                                                         | 2/20/072/20/07                           | --                                                                                 | --                                                                                             | --                                                                    | --                                                                             | --                                                   | --                                             | --58,000 | 144,000-- | 2.50-- | 263,714145,000 |
|                                                                                                                                                                |                                     |                                                                               |                                                                                           |                                                                  |                                                                           |                                                 |                                           |   |   |   |   |
| Kevin      J. Bratton                                                                                                                                          | 2/20/072/20/07                           | --                                                                                 | --                                                                                             | --                                                                    | --                                                                             | --                                                   | --                                             | --18,000 | 56,000-- | 2.50-- | 102,55645,000 |
|                                                                                                                                                                |                                     |                                                                               |                                                                                           |                                                                  |                                                                           |                                                 |                                           |   |   |   |   |
| William      F. Goeckeler                        | 2/20/072/20/07                           | --                                                                                 | --                                                                                             | --                                                                    | --                                                                             | --                                                   | --                                             | --20,000 | 63,000-- | 2.50-- | 115,37550,000 |
|                                                                                                                                                                |                                     |                                                                               |                                                                                           |                                                                  |                                                                           |                                                 |                                           |   |   |   |   |
| Kevin      G. Lokay(1)                                                                                                                                              | 11/13/0711/13/0711/13/0711/16/0711/20/07 |                                                                               |                                                                                           |                                                                  |                                                                           |                                                 |                                           | ----91,930129,074129,873 | 400,000100,000------ | 0.570.57------ | 156,27440,36252,40085,18983,119 |
|                                                                                                                                                                |                                     |                                                                               |                                                                                           |                                                                  |                                                                           |                                                 |                                           |   |   |   |   |
| Stephen      A. Ross                                                                                                                                                | 7/09/077/09/07                           |                                                                               |                                                                                           |                                                                  |                                                                           |                                                 |                                           | 20,000-- | --50,000 | --1.59 | 31,80056,967 |
|                                                                                                                                                                |                                     |                                                                               |                                                                                           |                                                                  |                                                                           |                                                 |                                           |   |   |   |   |
| William      J. Thomas                                                                                                                                              | 2/20/072/20/07                           | --                                                                                 | --                                                                                             | --                                                                    | --                                                                             | --                                                   | --                                             | 16,000-- | --50,000 | --2.50 | 40,00091,567 |

| (1) | Excludes      awards granted to Mr. Lokay in 2007 for his services as a non-employee      director. |
|-----|-----------------------------------------------------------------------------------------------------|

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|                                                                                                                                                                                                           | Option      Awards                                                             | Stock      Awards                                                                   |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------------------------------------------------------------------------------|-------------------------------------------------------------------------------------|
| Name                                                                                                                                                                                                           | Number      ofSecuritiesUnderlying      UnexercisedOptions      (#)Exercisable | Number      of Securities Underlying Unexercised Options (#)      Unexer-cisable(1) | Equity      Incentive Plan Awards: Number of Securities Underlying Unexercised      Unearned Options (#) | Option      Exercise Price ($) | Option      Expiration Date | Number      of Shares or Units of Stock That Have Not Vested (#) | Market      Value of Shares or Units of Stock That Have Not Vested    ($)(2) | Equity      Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights      That Have Not Vested (#) | Equity      Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units of      Other Rights That Have Not Vested ($) |
| (a)                                                                                                                                                                                                            | (b)                                                                            | (c)                                                                                 | (d) | (e) | (f) | (g) | (h) | (i) | (j) |
| Kevin      J.      Bratton                               | 31,3601,973--                                                                  | 62,720(3)3,947(3)56,000(4)                                                          | ------ | 2.582.592.50 | 11/8/201611/8/20162/20/2017 | 50,000(9)18,000(10) | 26,5009,540 | -- | -- |
|                                                                                                                                                                                                           |                                                                           |                                                                                |   |   |   |   |   |   |   |
| William      F. Goeckeler                                                                                                                                                                                      | 1,1071,5004,0002,6397,0005,0007,39630,00012,00020,000                          | ----------------6,000(5)40,000(6)63,000(4)                                          | ---------------------- | 26.7229.0649.6034.903.543.5311.4811.505.153.572.50 | 12/31/200912/19/20106/4/201112/18/201112/17/20121/14/201310/21/20136/15/20146/14/20154/4/20162/20/2017 | 12,000(11)10,667(12)15,000(13)20,000(10) | 6,3605,6547,95010,600       | --  | -- |
|                                                                                                                                                                                                           |                                                                           |                                                                                |   |   |   |   |   |   |   |
| Kevin      G. Lokay(16)                                                 |                                                                           | 400,000(7)100,000(7)                                                           | ----  | 0.570.57  | 11/13/201711/13/2017  | 91,930      (15)129,074(15)129,873(15) | 48,72368,40968,833 | --  | --  |
|                                                                                                                                                                                                           |                                                                           |                                                                                |   |   |   |   |   |   |   |
| Stephen      A.      Ross                                     |                                                                           | 50,000(8)                                                                      | --  | 1.59  | 7/9/2017  | 20,000(14)  | 10,600  |   |   |

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| (1) | Unless      otherwise noted, stock options vest 33.33% per year over three years on      the anniversary of the date of grant. Stock options expire 10 years from      their date of grant. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | The      closing price of our common stock at December 31, 2007 was $0.53 per      share. |
|-----|-------------------------------------------------------------------------------------------|

| (3) | Options      with vesting date of November 8, 2008 and November 8,  2009. |
|-----|---------------------------------------------------------------------------|

| (4) | Options      with vesting dates of February 20, 2008, February 20, 2009 and February      20, 2010. |
|-----|-----------------------------------------------------------------------------------------------------|

| (5) | Options      with vesting date of June 14, 2008. |
|-----|--------------------------------------------------|

| (6) | Options      with vesting dates of April 4, 2008 and April 4,  2009. |
|-----|----------------------------------------------------------------------|

| (7) | Stock      options vest 25% per year over four years on the anniversary of the date      of grant.  Options with vesting dates of December 18, 2008,      December 18, 2009, December 18, 2010 and December 18,  2011. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (8) | Options      with vesting dates of July 9, 2008, July 9, 2009 and July 9,      2010. |
|-----|--------------------------------------------------------------------------------------|

| (9) | Restricted      stock award that vests on November 8,2009. |
|-----|------------------------------------------------------------|

| (10) | Restricted      stock award that vests on February 20,2010. |
|------|-------------------------------------------------------------|

| (11) | Restricted      stock award that vests in equal installments on June 14, 2008, June 14,      2009, June 14, 2010 and June 14,2011. |
|------|------------------------------------------------------------------------------------------------------------------------------------|

| (12) | Restricted      stock award that vests in equal installments on April 4, 2008 and April 4,      2009. |
|------|-------------------------------------------------------------------------------------------------------|

| (13) | Restricted      stock award that vests on October 17,2009. |
|------|------------------------------------------------------------|

| (14) | Restricted      stock award that vests on July 9,2010. |
|------|--------------------------------------------------------|

| (15) | Restricted      stock award will vest upon the completion of certain performance-based      milestones established by the Board of  Directors. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------|

| (16) | Excludes      awards granted to Mr. Lokay for his services as a non-employee      director. |
|------|---------------------------------------------------------------------------------------------|

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Table of Contents

|   | Employment      Contracts, Termination of Employment and Change-in-Control      Arrangements |
|--------|----------------------------------------------------------------------------------------------|

|   | · | Mr.      Lokay receives an annual base salary of  $400,000; |
|--------|--------|-------------------------------------------------------------|

|   | · | Mr.      Lokay earns an annual bonus equal to up to 50% of Mr. Lokay’s annual base      salary, subject to achievement of certain performance goals established by      the compensation committee of the board of  directors; |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | Mr.      Lokay is entitled to twelve (12) months of severance in the event he is      terminated without cause; |
|--------|--------|-----------------------------------------------------------------------------------------------------------------|

|   | · | Mr.      Lokay is entitled to payment of up to $75,000 of relocation expenses if he      relocates within an 18 month period;and |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------|

|   | · | Mr.      Lokay is entitled to five (5) weeks of paid  vacation. |
|--------|--------|-----------------------------------------------------------------|

|   | · | make      a lump sum payment equal to the sum of the annual salary and a pro-rata      portion of the annual cash bonus; |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------|

|   | · | continue      health and life and disability insurance and other benefits for one year      from the date of termination; |
|--------|--------|---------------------------------------------------------------------------------------------------------------------------|

|   | · | provide      outplacement services for up to 12months; |
|--------|--------|--------------------------------------------------------|

|   | · | pay      any other accrued rights of theexecutive; |
|--------|--------|----------------------------------------------------|

|   | · | pay      a gross up amount for certain excise taxes imposed by the Internal Revenue      Code; and |
|--------|--------|----------------------------------------------------------------------------------------------------|

|   | · | in      certain circumstances, pay legal fees and costs in the event we wrongfully      refuse to provide the severancebenefits. |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------|

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| Name                                                                                                                                                                                                                                                                                                                                                                                                   |   | Severance      Payment(1) |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|---------------------------|
| Kevin      G.      Lokay                                                                   |   | $608,127                  |
| Kevin      J.      Bratton                                                                 |   | $300,536                  |
| William      F.      Goeckeler                                                             |   | $401,711                  |
| Stephen      A.      Ross                                                                  |   | $333,941                  |

----

| (1) | Payment      amounts are based on the followingcomponents: |
|-----|------------------------------------------------------------|

|   | · | base      pay using salary at end of 2007; |
|--------|--------|--------------------------------------------|

|   | · | annual      cash bonus, calculated by taking the 2007 target  bonus; |
|--------|--------|----------------------------------------------------------------------|

|   | · | health      and dental benefits, based on current COBRA  rates; |
|--------|--------|-----------------------------------------------------------------|

|   | · | life,      disability and long term care insurance premiums, based on current formula      calculations; and |
|--------|--------|--------------------------------------------------------------------------------------------------------------|

|   | · | accrued      vacation balances. |
|--------|--------|---------------------------------|

| Name                       | Fees      Earned or Paid in Cash ($)(1) | Stock      Awards ($)(2) | Option      Awards ($)(3) | Non-Equity      Incentive Plan Compensation ($) | Change      in Pension Value and Nonqualified Deferred Compensation      Earnings | All      Other Compensation ($)(4) | Total      ($) |
|----------------------------|-----------------------------------------|--------------------------|---------------------------|-------------------------------------------------|-----------------------------------------------------------------------------------|------------------------------------|----------------|
| (a)                        | (b)                                     | (c)                      | (d)                       | (e)                                             | (f)                                                                               | (g)                                | (h)            |
| James      A. Grigsby      | 101,000                                 | 10,953                   | 31,818                    | --                                              | --                                                                                | --                                 | 143,771        |
| John      E. Bagalay, Jr   | 73,500                                  | 10,953                   | 18,182                    | --                                              | --                                                                                | --                                 | 102,635        |
| Allen      Bloom           | 68,000                                  | 10,953                   | 18,182                    | --                                              | --                                                                                | --                                 | 97,135         |
| Stephen      K. Carter     | 60,500                                  | 10,953                   | 18,182                    | --                                              | --                                                                                | --                                 | 89,635         |
| Robert      F. Hendrickson | 65,500                                  | 10,953                   | 18,182                    | --                                              | --                                                                                | --                                 | 94,635         |
| Dennis      H. Langer      | 49,500                                  | 10,953                   | 22,154                    | --                                              | --                                                                                | --                                 | 82,607         |
| Kevin      G. Lokay(5)     | 36,000                                  | 10,953                   | 22,154                    | --                                              | --                                                                                | --                                 | 69,107         |
| Joseph      A. Mollica     | 63,000                                  | 10,953                   | 22,154                    | --                                              | --                                                                                | --                                 | 96,107         |

|   | (1) | Each      non-employee director of the Company may elect to receive all compensation      for services rendered as a member of the Cytogen board, any committees      thereof, and as board or committee chair, in the form of shares of common      stock, in cash or in a combination of shares of common stock and cash,      under the 2004 Non |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

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|   | Employee      Director Stock Incentive Plan, or the Director Plan, maintained by the      Company. Except as otherwise noted, each non-employee director elected to      receive all of their 2007 compensation in the form of  cash. |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (2) | These      amounts do not reflect compensation actually received by the named      directors.  Instead, the amounts reflect compensation expense      recognized by the Company in 2007 for stock awards, computed in accordance      with FAS 123(R).  The compensation expense reflects stock awards      in 2007 and excludes any reduction in value due to potential service-based      forfeiture assumptions.  Assumptions used in the calculation of      the compensation expense are included in Note 13 to the Company’s audited      financial statements.  The compensation expense does not      correspond to the actual value that may be realized by the named directors      with respect to these awards when and if they vest.  At December      31, 2007, each non-employee director has a restricted share award of      10,000 shares of the Company’s commonstock. |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (3) | These      amounts do not reflect compensation actually received by the named      directors.  Instead, the amounts reflect compensation expense      recognized by the Company in 2007 for option awards, computed in      accordance with FAS 123(R).  The compensation expense reflects      option awards granted in and prior to 2007 and excludes any reduction in      value due to potential service-based forfeiture      assumptions.  Assumptions used in the calculation of the      compensation expense are included in Note 13 to the Company’s audited      financial statements.  The compensation expense does not      correspond to the actual value that may be realized by the named directors      with respect to these options when and if they vest.  In 2007,      our independent directors were eligible to receive a stock option to      purchase 10,000 shares of our Common Stock upon re-election to the      Board at each annual meeting. The Chairman of the Board received an      additional grant of options to purchase 7,500 shares of common      stock.  These options vest on the one year anniversary of the      grant date.  As of December 31, 2007, our non-employee directors      hold stock options to acquire shares of our common stock, as follows: Mr.      Grigsby: 99,200 shares; Dr. Bagalay: 56,100 shares; Dr. Bloom: 52,000      shares; Dr. Carter: 55,987 shares; Mr. Hendrickson: 55,700 shares; Dr.      Langer: 30,000 shares;  and Dr. Mollica: 30,000      shares. |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (4) | Unless      otherwise indicated, none of the directors received any      (i) perquisites or personal benefits in an aggregate amount exceeding      $10,000 or (ii) other compensation not otherwise set forth in this      table. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (5) | Mr.      Lokay was appointed as our President and CEO in November      2007.  The amounts shown in the above table represent      compensation for his services and stock and option compensation for awards      prior to his appointment as President andCEO. |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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----

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|   | Robert      F. Hendrickson, Chairman |
|--------|--------------------------------------|

|   | Allen      Bloom, Member |
|--------|--------------------------|

|   | Dennis      H. Langer, Member |
|--------|-------------------------------|

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Table of Contents

Item 12.  

| Name      and Address of Beneficial Owner(1)                                                                 |   | Amount and Nature ofBeneficial Ownership(1)(2)                                                                                                                    |   | Percent of Class(3)                                                                                                         |
|--------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------------------------------------------------------------|
| (i)      Certain beneficial owners:                                                                          |   |                                                                                                                                                                                  |   |                                                                                                                                  |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| JP      Morgan Chase & Co.270      Park AvenueNew      York, New York 10017                              |   |  4,919,027                                                                                                                                                                       |   |  13.83%                                                                                                                          |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Millenco,      L.L.C.c/o      Millenium Management, L.L.C.666      Fifth AvenueNew      York, New York 10100 |   |  1,769,410                                                                                                                                                                       |   |  4.97%                                                                                                                           |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Orbimed      Advisors(4)767      Third Avenue, 30th      FloorNew      York, New York 10017                  |   |  2,139,800                                                                                                                                                                       |   |  5.86%                                                                                                                           |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| (ii)      Directors and Named Executives:                                                                    |   |                                                                                                                                                                                  |   |                                                                                                                                  |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| John      E. Bagalay, Jr.                                                                                    |   |                              48,100  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Allen      Bloom                                                                                             |   |                              44,000  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Stephen      K. Carter                                                                                       |   |                              47,987  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| James      A. Grigsby (7)                                                                               |   |                              88,700  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Robert      F. Hendrickson                                                                                   |   |                              48,700  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Dennis      H. Langer                                                                                        |   |                              22,000  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Kevin      G. Lokay                                                                                          |   |                              46,333  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Joseph      A. Mollica                                                                                       |   |                              22,000  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Kevin      J. Bratton                                                                                        |   |                              51,999  |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| William      F. Goeckeler                                                                                    |   |                              138,113 |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| Stephen      A. Ross                                                                                         |   |                              --      |   |                       * |
|                                                                                                         |   |                                                                                                                                                                                  |   |                                                                                                                                  |
| (iii)All      directors and executive officers as a group (11 persons)                                       |   |                              557,932 |   |  1.54%                                                                                                                           |

----

| * | Indicates      amount is less than 1%. |
|---|----------------------------------------|

| (1) | Except      as set forth in the footnotes to this table and subject to applicable      community property law, the persons and entities named in this table have      sole voting and investment power with respect to all shares. Unless otherwise      indicated, the address of each beneficial owner is c/o Cytogen      Corporation, 650 College Road East, Princeton, New Jersey      08540. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | Includes      the total of vested shares granted under restricted stock awards and      shares of our common stock which the following persons have the right to      acquire upon the exercise of stock options, within 60 days of March 27,      2008, as follows: Mr. Bagalay: 46,100 shares; Mr. Bloom: 42,000 shares;      Dr. Carter: 45,987 shares; Mr. Grigsby: 81,700  shares; |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| (3) | Percent      of class for each person and all executive officers and directors as a      group is based on 35,570,836 shares of our common stock outstanding on      March 27, 2008 and includes shares subject to options held by the      individual or the group, as applicable, which are exercisable or become      exercisable within 60 days following suchdate. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4) | Based      on a schedule 13G/A filed with the SEC on January 30, 2008 by J.P. Morgan      Chase & Co.  This reporting entity has sole voting power and      sole dispositive power as to, and beneficially owns, 4,919,027 shares of      our common stock.  The notice on Schedule 13G/A was filed on      behalf of J.P. Morgan Chase & Co. and its subsidiaries, J.P. Morgan      Securities Inc. and J.P. Morgan Ventures Corporation.  The      Company makes no representation as to the accuracy or completeness of the      information reported. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (5) | Based      on a Schedule 13D filed with the SEC on May 21, 2007 by Millenco, L.L.C.,      Millenium Management, L.L.C. and Israel A. Englander.  These      reporting entities have shared voting power and shared dispositive power      as to, and beneficially own, the following number of shares of our common      stock and warrants to purchase shares of our common stock:  (i)      Millenco, L.L.C.:  1,769,410; (ii) Millenium Management,      L.L.C.:  1,769,410; and (iii) Israel A.      Englander:  1,769,410.  Millenco, L.L.C. is the      beneficial owner of: (i) 1,681,486 shares of our common stock and (ii)      warrants to purchase 87,924 shares of our common      stock.  Millenium Management, L.L.C. is the manager of Millenco,      L.L.C. and may be deemed to be the beneficial owner of the shares      beneficially owned by Millenco, L.L.C. Mr. Englander is the managing      member of Millenium Management and may be deemed to be the beneficial      owner of the shares beneficially owned by Millenco, L.L.C.  The      foregoing should not be construed in and of itself as an admission by      Millenium Management, L.L.C. or Mr. Englander as to beneficial ownership      of the shares held by Millenco, L.L.C.  The Company makes no      representation as to the accuracy or completeness of the information      reported. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (6) | Based      on a Schedule 13G/A filed with the SEC on February 14, 2008 by OrbiMed      Advisors LLC, OrbiMed Capital LLC and Samuel D. Isalay.  These      reporting entities have shared voting power and shared dispositive power      as to, and beneficially own, the following number of shares of our common      stock and warrants to purchase shares of our common stock: (i) OrbiMed      Advisors LLC:  1,163,100; (ii) OrbiMed Capital      LLC:  976,700; and (iii) Samuel D.      Isalay:  2,139,800.  OrbiMed Advisors LLC and OrbiMed      Capital LLC hold shares and share equivalents issuable on the exercise of      warrants on behalf of Caduceus Capital Master Fund Limited (501,700 shares      and 382,500 warrants), Caduceus Capital II, L.P. (313,000 shares and      237,500 warrants), UBS Eucalyptus Fund, LLC (348,800 shares and 202,500      warrants), PW Eucalyptus Fund, Ltd. (38,800 shares and 22,500 warrants)      and Summer Street Life Sciences Hedge Fund Investors LLC (92,500      warrants).  The Company makes no representation as to the      accuracy or completeness of the information  reported. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (7) | Includes      2,000 shares of common stock held indirectly by Mr. Grigsby in the      registered name of Mr. Grigsby’sspouse. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------|

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| Plan      Category(1)                                                                                                                                                                                                                                                                                                                                                                                                                         |   | Number      ofsecurities to beissued      uponexercise      ofoutstandingoptions, warrantsand      rights(a) |   | Weighted-averageexercise      price ofoutstandingoptions,      warrantsand      rights(b) |   | Number of securitiesremaining available forfuture      issuance underequity      compensationplans      (excludingsecurities      reflected incolumn      (a))(c)(2) |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------------------------|--------|-------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (i)        Equity      compensation plans approved by security holders:                                                                                                                                                                                                                                                                                                                               |   |                                                                                                                        |   |                                                                                      |   |                                                                                                                                                                                     |
|                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                        |   |                                                                                      |   |                                                                                                                                                                                     |
| 2004      Stock Incentive Plan(3)                                                                                       |   | 1,082,630                                                                                                                   |   | $3.64                                                                                     |   | 12,704                                                                                                                                                                                   |
|                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                        |   |                                                                                      |   |                                                                                                                                                                                     |
| 2004      Non-Employee Director Stock IncentivePlan                                                                |   | 390,000                                                                                                                     |   | $6.06                                                                                     |   | 356,000                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                        |   |                                                                                      |   |                                                                                                                                                                                     |
| 2005      Employee Stock Purchase      Plan                                                                             |   | --                                                                                                                          |   | --                                                                                        |   | 331,894                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                        |   |                                                                                      |   |                                                                                                                                                                                     |
| 2006      Equity Compensation Plan(3)                                                                                   |   | 589,920                                                                                                                     |   | $2.01                                                                                     |   | 289,303                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                        |   |                                                                                      |   |                                                                                                                                                                                     |
| Other      equity compensation plans(4)                                                                                 |   | 261,877                                                                                                                     |   | $12.85                                                                                    |   | --                                                                                                                                                                                       |
|                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                        |   |                                                                                      |   |                                                                                                                                                                                     |
| (ii)            Equity compensation plans not approved by security holders                                                                                                                                                                                                                                                                                                                                      |   | 287,478                                                                                                                     |   | $7.42                                                                                     |   | --                                                                                                                                                                                       |
|                                                                                                                                                                                                                                                                                                                                                                                                                                          |   |                                                                                                                        |   |                                                                                      |   |                                                                                                                                                                                     |
| Total                                                                                                                                                                                                                                                                                                                                                                                                                                         |   | 2,611,905                                                                                                                   |   | $4.97                                                                                     |   | 989,901                                                                                                                                                                                  |

----

| (1) | Does      not include information related to the stock option plan of our      subsidiary, AxCell BioSciences Corporation, pursuant to which AxCell may      issue options to purchase shares of AxCell’s common stock to employees and      consultants of AxCell. Such plan did not require the approval of Cytogen’s      stockholders. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | In      addition to being available for future issuance upon the exercise of      options that may be granted after December 31, 2007, all shares available      for issuance under our 2004 Non-Employee Director Stock Incentive Plan may      instead be issued directly to eligible directors thereunder in payment for      services rendered to us. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | Excludes      82,501 and 620,777 shares of our common stock granted under restricted      stock awards pursuant to the terms of the 2004 Stock Incentive Plan and      2006 Equity Compensation Plan, respectively.  Such restricted      shares are subject to future vesting of up to six years and will be issued      upon the satisfaction of such vesting  provisions. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4) | We      no longer grant stock options under our: (i) 1988 Non-Employee Director      Plan; (ii) 1989 Outside Consultant Plan; (iii) 1995 Stock Option Plan, as      amended; and (iv) 1999 Non-Employee Director Plan, but stock option grants      exercisable for an aggregate of: 1,160; 5,000; 219,557; and 36,160 shares      of our common stock remain outstanding under those  plans. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

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Item 13. 

Item 14. 

| Fee      Category       |   | 2007   |    |   | 2006   |
|-------------------------|--------|--------|---------|--------|--------|
| Audit      Fees         |   | $      | 516,200 |   |   | $ | 675,400 |
| Audit-Related      Fees |   | $      | --      |   |   | $ | -- |
| Tax      Fees           |   | $      | 5,000   |   |   | $ | 51,900 |
| All      Other Fees     |   | $      | --      |   |   | $ | -- |
|                    |   |   |    |   |   |   |   |
| Total      Fees         |   | $      | 521,200 |   |   | $ | 727,300 |

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----

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Item 15.  Exhibits

| Exhibit No. |   |                                                                                                                                                                                                                                                                  |
|-------------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 31.1        |   | Certification      of President and Chief Executive Officer pursuant to Rule 13a-14(a) or      15d-14(a) of the Securities Exchange Act of 1934, as adopted pursuant to      Section 302 of the Sarbanes-Oxley Act of 2002. Filed    herewith.                        |
|        |   |                                                                                                                                                                                                                                                                  |
| 31.2        |   | Certification      of Senior Vice President, Finance and Chief Financial Officer pursuant to      Rule 13a-14(a) or 15d-14(a) of the Securities Exchange Act of 1934, as      adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. Filed      herewith. |

----

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SIGNATURES

|   | CYTOGEN      CORPORATION |
|--------|--------------------------|
|   |                     |   |
|   | By:                      | /s/  KEVIN      G. LOKAY |
|   |                     | Kevin      G. Lokay, |
|   |                     | President      and Chief Executive Officer |

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|   | Signature                            |   | Title                                                                                   |   | Date                |
|--------|--------------------------------------|--------|-----------------------------------------------------------------------------------------|--------|---------------------|
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  KEVIN      G. LOKAY   |   | President      and Chief Executive Officer                                              |   | April      29, 2008 |
|   | Kevin      G. Lokay                  |   | (Principal      Executive Officer and Director)                                         |   |                |
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  KEVIN      J. BRATTON |   | Senior      Vice President, Finance,                                                    |   | April      29, 2008 |
|   | Kevin      J. Bratton                |   |  and      Chief Financial Officer(Principal      Financial and Accounting Officer) |   |                |
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  *                     |   | Director                                                                                |   | April      29, 2008 |
|   | John      E. Bagalay, Jr.            |   |                                                                                    |   |                |
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  *                     |   | Director                                                                                |   | April      29, 2008 |
|   | Allen      Bloom                     |   |                                                                                    |   |                |
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  *                     |   | Director                                                                                |   | April      29, 2008 |
|   | Stephen      K. Carter               |   |                                                                                    |   |                |
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  *                     |   | Director      and Chairman of the Board                                                 |   | April      29, 2008 |
|   | James      A. Grigsby                |   |                                                                                    |   |                |
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  *                     |   | Director                                                                                |   | April      29, 2008 |
|   | Robert      F. Hendrickson           |   |                                                                                    |   |                |
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  *                     |   | Director                                                                                |   | April      29, 2008 |
|   | Dennis      H. Langer                |   |                                                                                    |   |                |
|   |                                 |   |                                                                                    |   |                |
| By:    | /s/  *                     |   | Director                                                                                |   | April      29, 2008 |
|   | Joseph      A. Mollica               |   |                                                                                    |   |                |

| * | By      the signature set forth below, the undersigned, pursuant to the duly      authorized powers of attorney filed with the Securities and Exchange      Commission has signed this Amendment No. 1 on Form 10-K/A on behalf of the      person indicated. |
|---|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| /s/  KEVIN.      G. LOKAY |   |
|-------------------------------------|--------|

| Kevin      G. Lokay |
|---------------------|

| (Attorney-in-Fact) |
|--------------------|