OAR Box 1112 

Prepped by Ryan Dugan 

Document Number: 

39) ll-C-5 

Docket Number: 

A-83-22 

Printed 4/16/2008 9:12:07AM Sheet 39 of 97 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

Office of Air Quality Planning and Standards 

/ Research Triangle Park, North Carolina 27711 

February 7, 1986 

Dr. Morton Lippmann 

Professor 

Department of Environmental Medicine 

New York University Medical Center 

Tuxedo, New York 10987 

Dear Dr. Lippmann: 

Enclosed for your review is the revised draft staff paper for lead 

that is to be discussed at the March 11-12, 1986 Clean Air Scientifi c 

Advisory Committee (CASAC) meeting. 

To facilitat e the review process, I would like to specificall y direct 

your attention to Section VII of the paper. In response to the Committee's 

comments and recommendations las t spring, the staff has substantially 

revised the discussion of averaging time, form and sampling frequency. 

In addition, the Section's discussion of health effects has been updated 

principall y to include several new studies on neurological effects 

and to incorporate the results of the probability encoding on lead-induced 

hemoglobin and IQ decrements. We have deferred, however, from full y 

incorporating the information on hypertension and stature unti l after 

CASAC review of the addendum to the criteri a document. Finally , the 

portion of Section VII that discusses approaches for estimating blood 

lead levels under alternative air lead levels has been revised to explicitl y 

reflec t CASAC's recommendation with respect to children livin g in 

deteriorating, lead-based painted homes. 

The summary and conclusion portion of Section VII I has also been 

revised, and a new Appendix E has been added which examines the long-term 

accumulation of lead in soi l in rural areas. Other portions of the paper 

have been revised and updated as appropriate. 

In updating the staff paper with respect to new studies, we have 

used the most current page numbers when referencing to the lead criteri a 

document. As a result, some of the page numbers cited wil l diffe r from 

those in early drafts of the criteri a document. 

In addition to the staff paper, we would also appreciate CASAC's 

comments and advice with respect to the lead exposure and risk assessment. 

At the meeting, we plan two presentations. The firs t wil l review in some 

detai l the exposure analysis methodology and preliminary results . As 

background information for thi s presentation, I am enclosing two reports 
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that address the exposure analysis and related demographic data. The 

second presentation will be on the initial results of the lead risk 

assessment. The enclosed draft report "Estimating the Risks of Lead-Induced 

Health Effects" discusses in some detail the results of probabilistic 

encoding for lead-induced hemoglobin and IQ decrements (Sections 3 and 4) 

and preliminary estimates of risks of adverse health effects under 

alternative air-lead scenarios (Section 5) . 

Finally, I have decided to defer any discussion of the lead benefit 

analysis until after the Committee has an opportunity to review the 

exposure/risk assessment. As previously indicated, we plan to use as 

appropriate, the results from the exposure/risk assessment in the 

benefits analysis and therefore, we thought it would be prudent to wait 

on CASAC review before proceeding further. 

We look forward to receiving your comments on the scientific and 

technical adequacy of the revised staff paper and the exposure/risk 

^ ... j.u. UpCOrnjng meeting. By copy of this letter, I am forwarding 

the other Committee members. 

assessment at the 

these materials to 

SincecelA*. ^? , 

-

r

yryxyy 

)ohn R. 0 Connor 

Director 

Strategies and Air Standards Division 

Enclosures 

cc: CASAC Members 

B. Flaak 

T. Yosie