Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460

Office of Chemical Safety and Pollution Prevention



### MEMORANDUM

Date: November 3, 2010

SUBJECT: Propiconazole: Acute and Chronic A ggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for the mint, bulb vegetables, caneberry subgroup 13- 07A, bushberry subgroup 13-07B, and low growing berry subgroup 13-07G.

PC Code: 122101 DP Barcode: D375283 Decision No.: 425825 Registration No.: 100-617 Petition No.: NA Regulat ory Action: Section 3 Risk Assessment Type: Dietary assessment Case No.: 3125. TXR No.: N/A CAS No.: 60207-90-1 MRID No.: N/A 40 CFR: § 180.434

FROM: Becky Daiss, Biologist Risk Assessment Branch IV Health Effects Division (7509P)

THROUGH: Thurston Morton, Chemist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (7509P)

And

Susan Hummel, Senior Scientist Risk Assessment Branch IV Health Effects Division (7509P)

TO: Janet Whitehurst, Risk Manager Review Fungicide Branch Registration Division (7505P)

This document provides the Health Effect s Division’s (HED’s) risk assessment of use of propiconazole on mint, bulb vegeta bles, caneberry subgroup 13-07A, bushberry subgroup 13-07B, and low grow ing berry subgroup 13-07G.Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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### Executive Summary

Acute and chronic aggregat e dietary (food and drinking water) exposure and risk assessments were conducted using the Di etary Exposure Evaluation Model DEEMFCIDTM, Version 2.03 which use food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of F ood Intakes by Individuals (CSFII) from 1994- 1996 and 1998. The analyses were performed to support the Secti on 3 registration on mint, bulb vegetables, caneberry subgr oup 13-07A, bushberry subgroup 13-07B, and low growing berry subgroup 13-07G.

Attached are acute and chronic dietary risk as sessments for this new use. This dietary assessment is for residues of propiconazo le and its metabolites convertible to 2,4- dichlorobenzoic acid (2,4-DCBA), expressed as propiconazole equi valents. The common metabolites- triazole, triazolylalanine (TA), triazolylacetic acid (TAA), and

t 

### riazolylpyruvic acid are also residues of concern. Sin ce these are common metabolites from several triazole pesticides, the risk assessment for triazoles will be assessed separately.

Acute Dietary (Food and Drinking Water) Ex posure Results and Characterization

An acute dietary analysis fo r propiconazole residues of concern was conducted using tolerance levels and 100 %CT for all existi ng and proposed uses. The acute PAD is 0.3 mg/kg/day for all population subgroups (incl udes females 13-49 years). The results of the analysis indicate that acute risk from the dietary exposure (food and water) to propiconazole from the requested uses did not exceed HED’s level of concern for the U.S. population or any population subgroup. At the 95 th 

### percentile, the exposure to the U.S. population is 7 % of the aPAD; the highe st exposed subgroup (Children 1-2 yrs old) is 17% of the aPAD.

Chronic Dietary (Food and Dr inking Water) Exposure Results and Characterization

A chronic dietary analysis for propiconazole residues of concer n was conducted using tolerance levels and 100 %CT for all ex isting and proposed uses. The cPAD is 0.1 mg/kg/day. Results of the anal ysis indicate that chronic risk from the dietary exposure (food and water) to propiconazole from the requested use did not exceed HED’s level of concern for the U.S. population or any popul ation subgroup. The exposure to the U.S. population is 7 % of the cPAD, and the most highly exposed subgroup, Children 1-2 years old, is 18 % of the cPAD.

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

The HED Carcinogenicity Peer Review Comm ittee (CPRC) classified propiconazole as Group C - possible human carcinogen and recommended that for the purpose of risk characterization the reference Dose (RfD) approach should be used and would be protective.Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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### I. Introduction

Propiconazole is a triazole-t ype fungicide that provides br oad spectrum disease control through inhibition of sterol biosynthesis in fungi. It is registered to Syngenta Crop Protection for the control of fungal diseases on a variety of crops. This dietary exposure assessment is for a proposed S ection 18 on Florida avocado.

Dietary risk assessment incorpor ates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED ha s concluded will result in no unreasonable adverse health effects). This dose is refe rred to as the population adjusted dose (PAD). The PAD is equivalent to point of depart ure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chroni c exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is gene rally concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/E PA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment fo r propiconazole was conducted by T. Morton (DP 380158, 07/21/10).

II. Residue Information

Residue Data used for Acute and Chronic Assessments:

These acute and chronic assessments were based on the assumption of tolerance-level residues for all commodities with existing and proposed tolerances and 100% crop treated (%CT) for all commodities. The existing to lerances are listed in 40 CFR §180.434. The proposed new tolerance levels used in the D EEM are presented in Table 1. DEEM default processing factors from DEEM (Version 7.81) were used for all processed commodities that do not have indi vidual tolerance.

Propiconazole existing tolerances:

Sec. 180. **434** Propiconazole; tolerances for residues.

(a) General.

----------------------------------------------------------------------- Parts per Commodity million

----------------------------------------------------------------------- Almond, hulls.............................................. 7.0
Banana...................................................... 0.2 Barley, bran................................................ 0.6 Barley, grain............................................... 0.3Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 4 of 21 Barley, hay................................................. 1.4 Barley, straw............................................... 10 Beet, sugar, dried pulp..................................... 1.0 Beet, sugar, molasses....................................... 1.5 Beet, sugar, roots.......................................... 0.3 Beet, sugar, tops........................................... 10 Berry, group 13............................................. 1.0 Carrot, roots............................................... 0.25 Cattle, fat................................................. 0.05 Cattle, kidney.............................................. 2.0 Cattle, liver............................................... 2.0 Cattle, meat................................................ 0.05 Cattle, meat byproducts, except liver and kidney............ 0.05 Corn, field, forage......................................... 12 Corn, field, grain.......................................... 0.2 Corn, field, stover......................................... 30 Corn, pop, grain............................................ 0.2 Corn, pop, stover........................................... 30 Corn, sweet, forage......................................... 6.0 Corn, sweet, kernel plus cob with husks removed............. 0.1 Corn, sweet, stover......................................... 30 Fruit, stone, group 12...................................... 1.0 Goat, fat................................................... 0.05 Goat, kidney................................................ 2.0 Goat, liver................................................. 2.0 Goat, meat.................................................. 0.05 Goat, meat byproducts, except liver and kidney.............. 0.05 Grain, aspirated fractions.................................. 30 Grass, forage............................................... 0.5 Grass, hay.................................................. 0.5 Grass, straw................................................ 40 Hog, kidney................................................. 0.2 Hog, liver.................................................. 0.2 Horse, fat.................................................. 0.05 Horse, kidney............................................... 2.0 Horse, liver................................................ 2.0 Horse, meat................................................. 0.05 Horse, meat byproducts, except liver and kidney............. 0.05 Leaf petioles, subgroup 4B.................................. 5.0 Milk........................................................ 0.05
Mushroom.................................................... 0.1 Nut, tree, group 14......................................... 0.1 Oat, forage................................................. 1.7 Oat, grain.................................................. 0.3 Oat, hay.................................................... 1.4 Oat, straw.................................................. 10 Onion, bulb................................................. 0.2 Onion, green................................................ 9.0
Peanut...................................................... 0.2 Peanut, hay................................................. 20 Peppermint, tops............................................ 3.5 Pineapple................................................... 0.1 Pistachio................................................... 0.1 Rice, bran.................................................. 15 Rice, grain................................................. 7.0 Rice, hulls................................................. 20 Rice, straw................................................. 18 Rye, bran................................................... 0.6 Rye, forage................................................. 1.7 Rye, grain.................................................. 0.3 Rye, straw.................................................. 10 Sheep, fat.................................................. 0.05Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 5 of 21 Sheep, kidney............................................... 2.0 Sheep, liver................................................ 2.0 Sheep, meat................................................. 0.05 Sheep, meat byproducts, except liver and kidney............. 0.05 Sorghum, grain, forage...................................... 12 Sorghum, grain, grain....................................... 3.5 Sorghum, grain, stover...................................... 15 Soybean, forage............................................. 11 Soybean, hay................................................ 30 Soybean, seed............................................... 2.0 Spearmint, tops............................................. 10.0 Strawberry.................................................. 1.3 Wheat, bran................................................. 0.6 Wheat, forage............................................... 1.7 Wheat, grain................................................ 0.3 Wheat, hay.................................................. 1.4 Wheat, straw................................................ 10

----------------------------------------------------------------------- (b) Section 18 emergency exemptions.

----------------------------------------------------------------------- Expiration/ Commodity Parts per revocation million date

----------------------------------------------------------------------- Nectarine....................................... 2.0 12/31/2010 Peach........................................... 2.0 12/31/2010

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(c) Tolerances with regional registrations

-----------------------------------------------------------------------

Parts per Commodity million

----------------------------------------------------------------------- Cranberry.................................................. 1.0 Rice, wild, grain........................................... 0.5

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(d) Indirect or inadvertent residues.

----------------------------------------------------------------------- Parts per Commodity million

----------------------------------------------------------------------- Alfalfa, forage............................................ 0.1 Alfalfa, hay................................................ 0.1

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[71 FR 55306, Sept. 22, 2006, as amended at 72 FR 20439, Apr. 25, 2007]  Note: Tolerances for additional food commodities have been establish but not**  **yet codified in the CRF**



### HED’s recommended tolerance associated with the Section 3 proposed use is provided in Table 1.Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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### Table 1. Tolerance Summary for Propiconazole

Crop Commodity Proposed

or Established Tolerance

(ppm) HED Recommended Tolerance (ppm) Comments ( Correct Commodity Definition)

Tolerances under §180.434(a) to be Removed Crop Group 13- Berries Group 1.0 Remove Mint, spearmint, tops 3.5 Remove Mint, peppermint, tops 3.5 Remove Onion, bulb 0.3 Remove Onion, green 9.0 Remove Strawberry 1.3 Remove Tolerances under §180.434(a) to be Added Mint, spearmint, tops 3.5 10.0 Data are adequate to support the use. Mint, peppermint, tops 3.5 10.0 Data are adequate to support the use. Onion, bulb subgroup 3-07A 0.2 0.2 Data are adequate to support the use. Onion, green, subgroup 3-07B 9.0 9.0 Data are adequate to support the use. Caneberry, subgroup 13-07A 1.0 1.0 Data are adequate to support the use. Bushberry, subgroup 13-07B 1.0 1.0 Data are adequate to support the use.

Low growing berry subgroup 13-07G, except cranberry 1.3 1.3 Tolerance is currently established for strawberry. Data are adequate to support the use.



### III. Drinking Water Data

The drinking water residues used in the di etary risk assessment were provided by the Environmental Fate and Effects Divisi on (EFED) in the following memorandum: “Drinking Water Assessment for Propiconazole Uses on Florida Avocado – Section 18 Emergency Exemption” (Jim Lin, 07/15/10, D379850) and incorporated directly into this dietary assessment. Water residues were in corporated in the DEEM-FCID into the food categories “water, direct, all sources” a nd “water, indirect, all sources.”

These results are based on EDWCs for Turf (DP 325821, 328690, 07/07/2006). The proposed new use does not result in higher EDWC s than those estimated for turf uses.

The estimated surface water drinking water c oncentrations for propiconazole are:

55.78 ug /L for the 1 in 10 year annual peak concentra tion (acute) 21.61 ug /L for the 1 in 10 year annual mean concentration (non-cancer chronic) and 13.24 ug /L for the 30 year annual mean c oncentration (cance r chronic).

The SCI-GROW estimated ground water drinking water concentrations for propiconazole are not expected to exceed 0.64 μ g/LPropiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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### The highest estimates from surface water (acute, 55.8 ppb and chronic, 21.6 ppb) are directly entered into th e exposure model to assess the cont ributions from drinking water.

The model and its description are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/

.
IV. DEEM-FCIDTM Program and Consumption Information

Propiconazole acute and chronic dietary expos ure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCIDTM, Version 2.03 which incorpor ates consumption data from USDA’s Continuing Surveys of Food Intakes by I ndividuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the reported cons umption of more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peel ed fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For ch ronic exposure assessment, consumption data are averaged for the en tire U.S. population a nd within population subgroups, but for acute exposure assessment are retained as i ndividual consumption events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey res pondents, HED concluded that it is most appropriate to report risk for the follo wing population subgroups: the general U.S. population, all infants (<1 year old), child ren 1-2, children 3-5, children 6-12, youth 13- 19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an es timate of the residue level in each food or food-form (e.g., orange or orange juice) on th e food commodity residue list is multiplied by the average daily consumption estimate fo r that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total av erage estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one -day food consumption data are used on an individual-by-individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate a nd summed to obtain a total daily pesticide exposure for a deterministic exposure asse ssment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of expos ures is expressed as a perc entage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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### V. Toxicological Information

HED’s Hazard Identification Assessment Re view Committee (HIARC) concluded that the toxicology database for propiconazole is complete for FQPA assessment. Endpoints and dose response have been selected fo r acute and chronic dietary exposures.

The HIARC also concluded that the database was adequate to characterize any potential for prenatal or postnatal risk for infants and children. Th ere is low concern for preand/or postnatal toxicity resulting from exposure to propiconazole, and no residual uncertainties were identified. The Special FQPA factor is thus 1X. The HIARC had previously determined that an acute ne urotoxicity (ACN) study was required based on neurotoxic signs in pregnant rats administered high propico nazole doses (360 mg/kg/day) during gestation. HIARC had determined that for acute (single dos e) and short-term exposure scenarios a 3X database uncertainty factor (UF DB 

### ) was adequate to account for the lack of the ACN. In September 2005 the ACN was submitted to the Agency and reviewed. The study confirms that neurotoxi c signs are observed at high doses, but there was no neuropathology and there were no e ffects on neurobehavioral parameters. Accordingly, the propiconazole risk assessm ent team determined that a developmental neurotoxicity study was not necessary and the database uncertainty factor for acute and short-term scenarios was removed.

The HED Carcinogenicity Peer Review Comm ittee (CPRC) classified propiconazole as Group C - possible human carcinogen and recommended that for the purpose of risk characterization the reference Dose (RfD) approach should be used and would be protective.

Table 2 Summary of Toxicological Doses a nd Endpoints for Propiconazole for Use in Dietary Exposure Risk Assessments

Exposure/ Scenario Point of Departure Uncertainty/FQPA Safety Factors RfD, PAD, Level of Concern Study and Toxicological Effects
Acute Dietary (General Population, including Infants and Children) NOAEL= 30 mg/kg/day UF A = 10x
UF H = 10x FQPA SF= 1x Acute RfD = 0.3 mg/kg/day

aPAD =0.3 mg/kg/day Acute neurotoxicity study LOAEL = 100 mg/kg/day based on clinical signs of toxicity (piloerection in one male, diarrhea in one female, tip toe gait in 3 females).

Acute Dietary (Females 13- 49 years of age) NOAEL = 30 mg/kg/day UF A = 10x
UF H = 10x FQPA SF= 1x Acute RfD = 0.3 mg/kg/day

aPAD =0.3 mg/kg/day Developmental Toxicity Study -
Rats. LOAEL = 90 mg/kg/day based

on increased incidence of rudimentary ribs, un-ossified sternebrae, as well as increased incidence of shortened and absent renal papillae and increased cleft palate. Chronic Dietary (All Populations) NOAEL= 10 mg/kg/day UF A = 10x
UF H = 10x FQPA SF= 1x Chronic RfD = 0.1 mg/kg/day 24-month oncogenicity study on CD-1 mice. LOAEL = 50 mg/kg/day basedPropiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 9 of 21 cPAD = 0.1mg/kg/day on non-neoplastic liver effects (increased liver weight in males and increase in liver lesions: masses/raised areas/ swellings/nodular areas mainly). Cancer (oral, dermal, inhalation) Classification: Group C, possible human carcinogen, RfD approach for risk characterization. Point of Departure (POD) = A data point or an estimate d point that is derived from observed dose-response data and used to mark the beginning of extra polation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (intraspecies). UF H = potential variation in sensitivity among members of the human population (interspecies). UF DB = to account for the absence of key data (i .e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable.



### VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table( s ) are for the general U.S. Population, all infa nts (<1 year old), children 1-2, children 3-4, children 6-12, youth 13-19, females 13-49, adu lts 20-49, and adults 50+ years.

At the 95 th 

### percentile, the acute dietary expos ure (food and water) to general US population is 7 % of the aPAD, and the mo st highly exposed subgroup, Children 1-2 yrs old, is 17 % of the aPAD. The chronic dietar y exposure to general US population is 7 % of the cPAD, and the most highly exposed s ubgroup, Children 1-2 yrs old, is 18 % of the cPAD. All the dietary risk estim ates are below 100% of the PADs.

These analyses are highly conservative dietar y exposure assessments. Further refinement to the analyses could be made through the us e of anticipated residues, incorporation of percentages of crops treated w ith propiconazole, and/or monito ring data that better reflect residues at the time of consumption. Since ri sk estimates are well below HED’s level of concern, a more highly refined analys is is not needed at this time.

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

Table 3. Results of Acute Dietary Exposure Analysis for Food and Water

Population Subgroup aPAD (mg/kg/day) 95th Percentile Exposure (mg/kg/day) % aPAD General U.S. Population

0.3 0.022053 7 All Infants (< 1 year old) 0.048257 16 Children 1-2 years old 0.051498 17 Children 3-5 years old 0.039652 13 Children 6-12 years old 0.027168 9 Youth 13-19 years old 0.018085 6 Adults 20-49 years old 0.017975 6 Adults 50+ years old 0.013576 5Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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### Table 3. Results of Acute Dietary Exposure Analysis for Food and Water

Population Subgroup aPAD (mg/kg/day) 95th Percentile Exposure (mg/kg/day) % aPAD Females 13-49 years old 0.016750 6



### Results of Chronic Dietary (Food an d Drinking Water) Exposure Analysis

Table 4. Results of Chronic Dietary Exposure Analysis for Food and Water

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) % cPAD General U.S. Population

0.1 0.006794 7 All Infants (< 1 year old) 0.015851 16 Children 1-2 years old 0.018210 18 Children 3-5 years old 0.014763 15 Children 6-12 years old 0.009627 10 Youth 13-19 years old 0.005891 6 Adults 20-49 years old 0.005685 6 Adults 50+ years old 0.004556 5 Females 13-49 years old 0.005369 5



### VII. Characterization of Inputs/Outputs

The acute and chronic analysis assumed tolerance-level residues, 100% CT, and empirical or DEEM TM default processing factors. Therefore, these analyses are considered conservative. Since risk estim ates are well below HED’s level of concern they do not warrant the need for fu rther refinement at this time.

VIII. Conclusions

These unrefined analyses demonstrate that th e requested uses for propiconazole will not result in dietary risk estimates that ex ceed HED’s level of concern for any of the regulated population subgroups, including thos e comprised of infants and children. A summary of the dietary exposure an alyses is given in Table 5.

Table 5. Summary of Dietary Exposure and Risk for Propiconazole FOOD PLUS WATER.

Population Subgroup Acute Dietary (95th Percentile) Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD Dietary Exposure (mg/kg/day) Risk

General U.S. Population 0.022053 7 0.006794 7

N/A All Infants (< 1 year old) 0.048257 16 0.015851 16 Children 1-2 years old 0.051498 17 0.018210 18 Children 3-5 years old 0.039652 13 0.014763 15 Children 6-12 years old 0.027168 9 0.009627 10 Youth 13-19 years old 0.018085 6 0.005891 6 Adults 20-49 years old 0.017975 6 0.005685 6 Adults 50+ years old 0.013576 5 0.004556 5Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 11 of 21 Table 5. Summary of Dietary Exposure and Risk for Propiconazole FOOD PLUS WATER.

Population Subgroup Acute Dietary (95th Percentile) Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD Dietary Exposure (mg/kg/day) Risk

Females 13-49 years old 0.016750 6 0.005369 5



### IX. List of Attachments

Attachment 1. Acute Food plus Water Residue Input file. Attachment 2. Acute Results file. Attachment 3. Chronic Food plus Water Residue Input file. Attachment 4. Chronic Results file.Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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### Attachment 1. Acute Food plus Water Residue Input file.

U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID Acute analysis for PROPICONAZOLE Residue file name: F:\Propiconazole\122101 Acute 9-2010 Sec 3 onion-berry.R98 Analysis Date 11-02-2010 Residue file dated: 10-21-2010/15:19:45/8 Reference dose (aRfD) = 0.3 mg/kg bw/day

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 14000030 14 Almond 0.100000 1.000 1.000 14000031 14 Almond-babyfood 0.100000 1.000 1.000 14000040 14 Almond, oil 0.100000 1.000 1.000 14000041 14 Almond, oil-babyfood 0.100000 1.000 1.000 12000120 12 Apricot 1.000000 1.000 1.000 12000121 12 Apricot-babyfood 1.000000 1.000 1.000 12000130 12 Apricot, dried 1.000000 6.000 1.000 12000140 12 Apricot, juice 1.000000 1.000 1.000 12000141 12 Apricot, juice-babyfood 1.000000 1.000 1.000
95000200 O Avocado 10.000000 1.000 1.000
95000230 O Banana 0.200000 1.000 1.000 95000231 O Banana-babyfood 0.200000 1.000 1.000 95000240 O Banana, dried 0.200000 3.900 1.000 95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 15000250 15 Barley, pearled barley 0.300000 1.000 1.000 15000251 15 Barley, pearled barley-babyfood 0.300000 1.000 1.000 15000260 15 Barley, flour 0.300000 1.000 1.000 15000261 15 Barley, flour-babyfood 0.300000 1.000 1.000 15000270 15 Barley, bran 0.600000 1.000 1.000 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, meat byproducts 0.050000 1.000 1.000 21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 21000470 M Beef, fat 0.050000 1.000 1.000 21000471 M Beef,fat-babyfood 0.050000 1.000 1.000 21000480 M Beef, kidney 2.000000 1.000 1.000 21000490 M Beef, liver 2.000000 1.000 1.000 21000491 M Beef, liver-babyfood 2.000000 1.000 1.000 01010500 1AB Beet, garden, roots 0.300000 1.000 1.000 01010501 1AB Beet, garden, roots-babyfood 0.300000 1.000 1.000 02000510 2 Beet, garden, tops 5.500000 1.000 1.000 01010520 1A Beet, sugar 0.300000 1.000 1.000 01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 01010530 1A Beet, sugar, molasses 1.500000 1.000 1.000 01010531 1A Beet, sugar, molasses-babyfood 1.500000 1.000 1.000 13010550 13A Blackberry 1.000000 1.000 1.000 13010560 13A Blackberry, juice 1.000000 1.000 1.000 13010561 13A Blackberry, juice-babyfood 1.000000 1.000 1.000 13020570 13B Blueberry 1.300000 1.000 1.000 13020571 13B Blueberry-babyfood 1.300000 1.000 1.000 13010580 13A Boysenberry 1.000000 1.000 1.000 14000590 14 Brazil nut 0.100000 1.000 1.000
14000680 14 Butternut 0.100000 1.000 1.000
04020760 4B Cardoon 5.000000 1.000 1.000
01010780 1AB Carrot 0.250000 1.000 1.000 01010781 1AB Carrot-babyfood 0.250000 1.000 1.000 01010790 1AB Carrot, juice 0.250000 1.000 1.000
14000810 14 Cashew 0.100000 1.000 1.000 04020850 4B Celery 5.000000 1.000 1.000 04020851 4B Celery-babyfood 5.000000 1.000 1.000 04020860 4B Celery, juice 5.000000 1.000 1.000
04020870 4B Celtuce 5.000000 1.000 1.000 12000900 12 Cherry 1.000000 1.000 1.000Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 13 of 21 12000901 12 Cherry-babyfood 1.000000 1.000 1.000 12000910 12 Cherry, juice 1.000000 1.500 1.000 12000911 12 Cherry, juice-babyfood 1.000000 1.500 1.000
14000920 14 Chestnut 0.100000 1.000 1.000 19011030 19A Chive 9.000000 1.000 1.000 15001200 15 Corn, field, flour 0.200000 1.000 1.000 15001201 15 Corn, field, flour-babyfood 0.200000 1.000 1.000 15001210 15 Corn, field, meal 0.200000 1.000 1.000 15001211 15 Corn, field, meal-babyfood 0.200000 1.000 1.000 15001220 15 Corn, field, bran 0.200000 1.000 1.000 15001230 15 Corn, field, starch 0.200000 1.000 1.000 15001231 15 Corn, field, starch-babyfood 0.200000 1.000 1.000 15001240 15 Corn, field, syrup 0.200000 1.500 1.000 15001241 15 Corn, field, syrup-babyfood 0.200000 1.500 1.000 15001250 15 Corn, field, oil 0.200000 1.000 1.000 15001251 15 Corn, field, oil-babyfood 0.200000 1.000 1.000 15001260 15 Corn, pop 0.200000 1.000 1.000 15001270 15 Corn, sweet 0.100000 1.000 1.000 15001271 15 Corn, sweet-babyfood 0.100000 1.000 1.000
13021360 13B Currant 1.000000 1.000 1.000 13021370 13B Currant, dried 1.000000 1.000 1.000 13011420 13A Dewberry 1.000000 1.000 1.000 13021490 13B Elderberry 1.000000 1.000 1.000 04021520 4B Fennel, Florence 5.000000 1.000 1.000 14001550 14 Filbert 0.100000 1.000 1.000 14001560 14 Filbert, oil 0.100000 1.000 1.000 03001640 3 Garlic 0.200000 1.000 1.000 03001650 3 Garlic, dried 0.200000 1.000 1.000 03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.050000 1.000 1.000 23001710 M Goat, fat 0.050000 1.000 1.000 23001720 M Goat, kidney 2.000000 1.000 1.000 23001730 M Goat, liver 2.000000 1.000 1.000 13021740 13B Gooseberry 1.000000 1.000 1.000 14001850 14 Hickory nut 0.100000 1.000 1.000 24001890 M Horse, meat 0.050000 1.000 1.000 13021910 13B Huckleberry 1.000000 1.000 1.000
03001980 3 Leek 9.000000 1.000 1.000 13012080 13A Loganberry 1.000000 1.000 1.000 14002130 14 Macadamia nut 0.100000 1.000 1.000 27002220 D Milk, fat 0.050000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 27012230 D Milk, nonfat solids 0.050000 1.000 1.000 27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 27022240 D Milk, water 0.050000 1.000 1.000 27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000
95002280 O Mushroom 0.100000 1.000 1.000 12002300 12 Nectarine 2.000000 1.000 1.000 15002310 15 Oat, bran 0.600000 1.000 1.000 15002320 15 Oat, flour 0.300000 1.000 1.000 15002321 15 Oat, flour-babyfood 0.300000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.300000 1.000 1.000 15002331 15 Oat, groats/rolled oats-babyfood 0.300000 1.000 1.000 03002370 3 Onion, dry bulb 0.200000 1.000 1.000 03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 03002390 3 Onion, green 9.000000 1.000 1.000 04012480 4A Parsley, leaves 13.000000 1.000 1.000 19012490 19A Parsley, dried leaves 35.000000 1.000 1.000 19012491 19A Parsley, dried leaves-babyfood 35.000000 1.000 1.000
12002600 12 Peach 2.000000 1.000 1.000 12002601 12 Peach-babyfood 2.000000 1.000 1.000 12002610 12 Peach, dried 2.000000 7.000 1.000Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 14 of 21 12002611 12 Peach, dried-babyfood 2.000000 7.000 1.000 12002620 12 Peach, juice 2.000000 1.000 1.000 12002621 12 Peach, juice-babyfood 2.000000 1.000 1.000
95002630 O Peanut 0.200000 1.000 1.000 95002640 O Peanut, butter 0.200000 1.890 1.000 95002650 O Peanut, oil 0.200000 1.000 1.000
14002690 14 Pecan 0.100000 1.000 1.000 95002750 O Peppermint 10.000000 1.000 1.000 95002760 O Peppermint, oil 10.000000 1.000 1.000 95002790 O Pineapple 4.500000 1.000 1.000 95002791 O Pineapple-babyfood 4.500000 1.000 1.000 95002800 O Pineapple, dried 4.500000 5.000 1.000 95002810 O Pineapple, juice 4.500000 1.700 1.000 95002811 O Pineapple, juice-babyfood 4.500000 1.700 1.000 14002820 14 Pistachio 0.100000 1.000 1.000 95002830 O Plantain 0.200000 1.000 1.000 95002840 O Plantain, dried 0.200000 3.900 1.000
12002850 12 Plum 1.000000 1.000 1.000 12002851 12 Plum-babyfood 1.000000 1.000 1.000 12002860 12 Plum, prune, fresh 1.000000 1.000 1.000 12002861 12 Plum, prune, fresh-babyfood 1.000000 1.000 1.000 12002870 12 Plum, prune, dried 1.000000 5.000 1.000 12002871 12 Plum, prune, dried-babyfood 1.000000 5.000 1.000 12002880 12 Plum, prune, juice 1.000000 1.400 1.000 12002881 12 Plum, prune, juice-babyfood 1.000000 1.400 1.000 25002940 M Pork, kidney 0.200000 1.000 1.000 25002950 M Pork, liver 0.200000 1.000 1.000 13013200 13A Raspberry 1.000000 1.000 1.000 13013201 13A Raspberry-babyfood 1.000000 1.000 1.000 13013210 13A Raspberry, juice 1.000000 1.000 1.000 13013211 13A Raspberry, juice-babyfood 1.000000 1.000 1.000
04023220 4B Rhubarb 5.000000 1.000 1.000 15003230 15 Rice, white 7.000000 1.000 1.000 15003231 15 Rice, white-babyfood 7.000000 1.000 1.000 15003240 15 Rice, brown 7.000000 1.000 1.000 15003241 15 Rice, brown-babyfood 7.000000 1.000 1.000 15003250 15 Rice, flour 7.000000 1.000 1.000 15003251 15 Rice, flour-babyfood 7.000000 1.000 1.000 15003260 15 Rice, bran 15.000000 1.000 1.000 15003261 15 Rice, bran-babyfood 15.000000 1.000 1.000 15003280 15 Rye, grain 0.300000 1.000 1.000 15003290 15 Rye, flour 0.300000 1.000 1.000
03003380 3 Shallot 110-Uncooked; Fresh or N/S; Cook Meth N/S
9.000000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 26003410 M Sheep, fat 0.050000 1.000 1.000 26003411 M Sheep, fat-babyfood 0.050000 1.000 1.000 26003420 M Sheep, kidney 2.000000 1.000 1.000 26003430 M Sheep, liver 2.000000 1.000 1.000 15003440 15 Sorghum, grain 3.500000 1.000 1.000 15003450 15 Sorghum, syrup 3.500000 1.000 1.000 06003470 6 Soybean, seed 2.000000 1.000 1.000 06003480 6 Soybean, flour 2.000000 1.000 1.000 06003481 6 Soybean, flour-babyfood 2.000000 1.000 1.000 06003490 6 Soybean, soy milk 2.000000 1.000 1.000 06003491 6 Soybean, soy milk-babyfood or in 2.000000 1.000 1.000 06003500 6 Soybean, oil 2.000000 1.000 1.000 06003501 6 Soybean, oil-babyfood 2.000000 1.000 1.000 95003520 O Spearmint 10.000000 1.000 1.000 95003530 O Spearmint, oil 10.000000 1.000 1.000 95003590 O Strawberry 1.300000 1.000 1.000 95003591 O Strawberry-babyfood 1.300000 1.000 1.000 95003600 O Strawberry, juice 1.300000 1.000 1.000Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 15 of 21 95003601 O Strawberry, juice-babyfood 1.300000 1.000 1.000 04023670 4B Swiss chard 5.000000 1.000 1.000
14003910 14 Walnut 0.100000 1.000 1.000 86010000 O Water, direct, all sources 0.055780 1.000 1.000 86020000 O Water, indirect, all sources 0.055780 1.000 1.000 15004010 15 Wheat, grain 0.300000 1.000 1.000 15004011 15 Wheat, grain-babyfood 0.300000 1.000 1.000 15004020 15 Wheat, flour 0.300000 1.000 1.000 15004021 15 Wheat, flour-babyfood 0.300000 1.000 1.000 15004030 15 Wheat, germ 0.300000 1.000 1.000 15004040 15 Wheat, bran 0.600000 1.000 1.000 15004050 15 Wild rice 0.500000 1.000 1.000Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 16 of 21 

### Attachment 2. Acute Results file.

U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID ACUTE Analysis for PROPICONAZOLE (1994-98 data) Residue file: 122101 Acute 11-2010 Sec 3 onion-berry.R98 Adjustment factor #2 used. Analysis Date: 11-02-2010/12:41:31 Residue file dated: 11-02-2010/12:39:13/8 Daily totals for food and foodform consumption used.

Run Comment: ""

=============================================================================== Summary calculations (per capita): 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- U.S. Population:
0.022053 7.35 0.043053 14.35 0.103206 34.40 All infants:
0.048257 16.09 0.092643 30.88 0.193451 64.48 Children 1-2 yrs:
0.051498 17.17 0.107669 35.89 0.227555 75.85 Children 3-5 yrs:
0.039652 13.22 0.077797 25.93 0.165884 55.29 Children 6-12 yrs:
0.027168 9.06 0.048677 16.23 0.091368 30.46 Youth 13-19 yrs:
0.018085 6.03 0.037976 12.66 0.063187 21.06 Adults 20-49 yrs:
0.017875 5.96 0.033385 11.13 0.089708 29.90 Adults 50+ yrs:
0.013476 4.49 0.025847 8.62 0.050520 16.84 Females 13-49 yrs:
0.016750 5.58 0.030972 10.32 0.093215 31.07Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 17 of 21 

### Attachment 3. Chronic Food plus Water Residue Input file.

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for PROPICONAZOLE 1994-98 data Residue file: F:\Propiconazole\122101 Chronic 11-2010 Sec 3 onion-berry.R98 Adjust. #2 used Analysis Date 11-02-2010 Residue file dated: 11-02-2010/12:40:30/8 Reference dose (RfD) = 0.1 mg/kg bw/day

-------------------------------------------------------------------------------- Food Crop Residue Adj.Factors

Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ -----

-- 14000030 14 Almond 0.100000 1.000 1.000 14000031 14 Almond-babyfood 0.100000 1.000 1.000 14000040 14 Almond, oil 0.100000 1.000 1.000 14000041 14 Almond, oil-babyfood 0.100000 1.000 1.000 12000120 12 Apricot 1.000000 1.000 1.000 12000121 12 Apricot-babyfood 1.000000 1.000 1.000 12000130 12 Apricot, dried 1.000000 6.000 1.000 12000140 12 Apricot, juice 1.000000 1.000 1.000 12000141 12 Apricot, juice-babyfood 1.000000 1.000 1.000
95000200 O Avocado 10.000000 1.000 1.000
95000230 O Banana 0.200000 1.000 1.000 95000231 O Banana-babyfood 0.200000 1.000 1.000 95000240 O Banana, dried 0.200000 3.900 1.000 95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 15000250 15 Barley, pearled barley 0.300000 1.000 1.000 15000251 15 Barley, pearled barley-babyfood 0.300000 1.000 1.000 15000260 15 Barley, flour 0.300000 1.000 1.000 15000261 15 Barley, flour-babyfood 0.300000 1.000 1.000 15000270 15 Barley, bran 0.600000 1.000 1.000 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, meat byproducts 0.050000 1.000 1.000 21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 21000470 M Beef, fat 0.050000 1.000 1.000 21000471 M Beef,fat-babyfood 0.050000 1.000 1.000 21000480 M Beef, kidney 2.000000 1.000 1.000 21000490 M Beef, liver 2.000000 1.000 1.000 21000491 M Beef, liver-babyfood 2.000000 1.000 1.000 01010500 1AB Beet, garden, roots 0.300000 1.000 1.000 01010501 1AB Beet, garden, roots-babyfood 0.300000 1.000 1.000 02000510 2 Beet, garden, tops 5.500000 1.000 1.000 01010520 1A Beet, sugar 0.300000 1.000 1.000 01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 01010530 1A Beet, sugar, molasses 1.500000 1.000 1.000 01010531 1A Beet, sugar, molasses-babyfood 1.500000 1.000 1.000 13010550 13A Blackberry 1.000000 1.000 1.000 13010560 13A Blackberry, juice 1.000000 1.000 1.000 13010561 13A Blackberry, juice-babyfood 1.000000 1.000 1.000 13020570 13B Blueberry 1.300000 1.000 1.000 13020571 13B Blueberry-babyfood 1.300000 1.000 1.000 13010580 13A Boysenberry 1.000000 1.000 1.000 14000590 14 Brazil nut 0.100000 1.000 1.000
14000680 14 Butternut 0.100000 1.000 1.000
04020760 4B Cardoon 5.000000 1.000 1.000
01010780 1AB Carrot 0.250000 1.000 1.000 01010781 1AB Carrot-babyfood 0.250000 1.000 1.000 01010790 1AB Carrot, juice 0.250000 1.000 1.000
14000810 14 Cashew 0.100000 1.000 1.000Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 18 of 21 04020850 4B Celery 5.000000 1.000 1.000 04020851 4B Celery-babyfood 5.000000 1.000 1.000 04020860 4B Celery, juice 5.000000 1.000 1.000
04020870 4B Celtuce 5.000000 1.000 1.000 12000900 12 Cherry 1.000000 1.000 1.000 12000901 12 Cherry-babyfood 1.000000 1.000 1.000 12000910 12 Cherry, juice 1.000000 1.500 1.000 12000911 12 Cherry, juice-babyfood 1.000000 1.500 1.000
14000920 14 Chestnut 0.100000 1.000 1.000 15001200 15 Corn, field, flour 0.200000 1.000 1.000 15001201 15 Corn, field, flour-babyfood 0.200000 1.000 1.000 15001210 15 Corn, field, meal 0.200000 1.000 1.000 15001211 15 Corn, field, meal-babyfood 0.200000 1.000 1.000 15001220 15 Corn, field, bran 0.200000 1.000 1.000 15001230 15 Corn, field, starch 0.200000 1.000 1.000 15001231 15 Corn, field, starch-babyfood 0.200000 1.000 1.000 15001240 15 Corn, field, syrup 0.200000 1.500 1.000 15001241 15 Corn, field, syrup-babyfood 0.200000 1.500 1.000 15001250 15 Corn, field, oil 0.200000 1.000 1.000 15001251 15 Corn, field, oil-babyfood 0.200000 1.000 1.000 15001260 15 Corn, pop 0.200000 1.000 1.000 15001270 15 Corn, sweet 0.100000 1.000 1.000 15001271 15 Corn, sweet-babyfood 0.100000 1.000 1.000 95001300 O Cranberry 1.000000 1.000 1.000 95001301 O Cranberry-babyfood 1.000000 1.000 1.000 95001310 O Cranberry, dried 1.000000 1.000 1.000 95001320 O Cranberry, juice 1.000000 1.000 1.000 95001321 O Cranberry, juice-babyfood 1.000000 1.000 1.000
13021360 13B Currant 1.000000 1.000 1.000 13021370 13B Currant, dried 1.000000 1.000 1.000 13011420 13A Dewberry 1.000000 1.000 1.000 13021490 13B Elderberry 1.000000 1.000 1.000 04021520 4B Fennel, Florence 5.000000 1.000 1.000 14001550 14 Filbert 0.100000 1.000 1.000 14001560 14 Filbert, oil 0.100000 1.000 1.000 03001640 3 Garlic 0.200000 1.000 1.000 03001650 3 Garlic, dried 0.200000 1.000 1.000 03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.050000 1.000 1.000 23001710 M Goat, fat 0.050000 1.000 1.000 23001720 M Goat, kidney 2.000000 1.000 1.000 23001730 M Goat, liver 2.000000 1.000 1.000 13021740 13B Gooseberry 1.000000 1.000 1.000 14001850 14 Hickory nut 0.100000 1.000 1.000 24001890 M Horse, meat 0.050000 1.000 1.000 13021910 13B Huckleberry 1.000000 1.000 1.000
03001980 3 Leek 9.000000 1.000 1.000 13012080 13A Loganberry 1.000000 1.000 1.000 14002130 14 Macadamia nut 0.100000 1.000 1.000 27002220 D Milk, fat 0.050000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 27012230 D Milk, nonfat solids 0.050000 1.000 1.000 27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 27022240 D Milk, water 0.050000 1.000 1.000 27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000
95002280 O Mushroom 0.100000 1.000 1.000 12002300 12 Nectarine 2.000000 1.000 1.000 15002310 15 Oat, bran 0.600000 1.000 1.000 15002320 15 Oat, flour 0.300000 1.000 1.000 15002321 15 Oat, flour-babyfood 0.300000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.300000 1.000 1.000 15002331 15 Oat, groats/rolled oats-babyfood 0.300000 1.000 1.000 03002370 3 Onion, dry bulb 0.200000 1.000 1.000 03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 19 of 21 03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 03002390 3 Onion, green 9.000000 1.000 1.000 04012480 4A Parsley, leaves 13.000000 1.000 1.000 19012490 19A Parsley, dried leaves 35.000000 1.000 1.000 19012491 19A Parsley, dried leaves-babyfood 35.000000 1.000 1.000
12002600 12 Peach 2.000000 1.000 1.000 12002601 12 Peach-babyfood 2.000000 1.000 1.000 12002610 12 Peach, dried 2.000000 7.000 1.000 12002611 12 Peach, dried-babyfood 2.000000 7.000 1.000 12002620 12 Peach, juice 2.000000 1.000 1.000 12002621 12 Peach, juice-babyfood 2.000000 1.000 1.000
95002630 O Peanut 0.200000 1.000 1.000 95002640 O Peanut, butter 0.200000 1.890 1.000 95002650 O Peanut, oil 0.200000 1.000 1.000
14002690 14 Pecan 0.100000 1.000 1.000 95002750 O Peppermint 10.000000 1.000 1.000 95002760 O Peppermint, oil 10.000000 1.000 1.000 95002790 O Pineapple 4.500000 1.000 1.000 95002791 O Pineapple-babyfood 4.500000 1.000 1.000 95002800 O Pineapple, dried 4.500000 5.000 1.000 95002810 O Pineapple, juice 4.500000 1.700 1.000 95002811 O Pineapple, juice-babyfood 4.500000 1.700 1.000 14002820 14 Pistachio 0.100000 1.000 1.000 95002830 O Plantain 0.200000 1.000 1.000 95002840 O Plantain, dried 0.200000 3.900 1.000
12002850 12 Plum 1.000000 1.000 1.000 12002851 12 Plum-babyfood 1.000000 1.000 1.000 12002860 12 Plum, prune, fresh 1.000000 1.000 1.000 12002861 12 Plum, prune, fresh-babyfood 1.000000 1.000 1.000 12002870 12 Plum, prune, dried 1.000000 5.000 1.000 12002871 12 Plum, prune, dried-babyfood 1.000000 5.000 1.000 12002880 12 Plum, prune, juice 1.000000 1.400 1.000 12002881 12 Plum, prune, juice-babyfood 1.000000 1.400 1.000 25002940 M Pork, kidney 0.200000 1.000 1.000 25002950 M Pork, liver 0.200000 1.000 1.000 13013200 13A Raspberry 1.000000 1.000 1.000 13013201 13A Raspberry-babyfood 1.000000 1.000 1.000 13013210 13A Raspberry, juice 1.000000 1.000 1.000 13013211 13A Raspberry, juice-babyfood 1.000000 1.000 1.000
04023220 4B Rhubarb 5.000000 1.000 1.000 15003230 15 Rice, white 7.000000 1.000 1.000 15003231 15 Rice, white-babyfood 7.000000 1.000 1.000 15003240 15 Rice, brown 7.000000 1.000 1.000 15003241 15 Rice, brown-babyfood 7.000000 1.000 1.000 15003250 15 Rice, flour 7.000000 1.000 1.000 15003251 15 Rice, flour-babyfood 7.000000 1.000 1.000 15003260 15 Rice, bran 15.000000 1.000 1.000 15003261 15 Rice, bran-babyfood 15.000000 1.000 1.000 15003280 15 Rye, grain 0.300000 1.000 1.000 15003290 15 Rye, flour 0.300000 1.000 1.000
03003380 3 Shallot 0.200000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 26003410 M Sheep, fat 0.050000 1.000 1.000 26003411 M Sheep, fat-babyfood 0.050000 1.000 1.000 26003420 M Sheep, kidney 2.000000 1.000 1.000 26003430 M Sheep, liver 2.000000 1.000 1.000 15003440 15 Sorghum, grain 3.500000 1.000 1.000 15003450 15 Sorghum, syrup 3.500000 1.000 1.000 06003470 6 Soybean, seed 2.000000 1.000 1.000 06003480 6 Soybean, flour 2.000000 1.000 1.000 06003481 6 Soybean, flour-babyfood 2.000000 1.000 1.000 06003490 6 Soybean, soy milk 2.000000 1.000 1.000 06003491 6 Soybean, soy milk-babyfood or in 2.000000 1.000 1.000Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 20 of 21 06003500 6 Soybean, oil 2.000000 1.000 1.000 06003501 6 Soybean, oil-babyfood 2.000000 1.000 1.000 95003520 O Spearmint 10.000000 1.000 1.000 95003530 O Spearmint, oil 10.000000 1.000 1.000 95003590 O Strawberry 1.300000 1.000 1.000 95003591 O Strawberry-babyfood 1.300000 1.000 1.000 95003600 O Strawberry, juice 1.300000 1.000 1.000 95003601 O Strawberry, juice-babyfood 1.300000 1.000 1.000 04023670 4B Swiss chard 5.000000 1.000 1.000
14003910 14 Walnut 0.100000 1.000 1.000 86010000 O Water, direct, all sources 0.021610 1.000 1.000 86020000 O Water, indirect, all sources 0.021610 1.000 1.000 15004010 15 Wheat, grain 0.300000 1.000 1.000 15004011 15 Wheat, grain-babyfood 0.300000 1.000 1.000 15004020 15 Wheat, flour 0.300000 1.000 1.000 15004021 15 Wheat, flour-babyfood 0.300000 1.000 1.000 15004030 15 Wheat, germ 0.300000 1.000 1.000 15004040 15 Wheat, bran 0.600000 1.000 1.000 15004050 15 Wild rice 0.500000 1.000 1.000Propiconazole Dietary Exposure and Risk Assessment DP Number: D375283 PC Code: 122101

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Page 21 of 21 

### Attachment 4. Chronic Results file.

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for PROPICONAZOLE (1994-98 data) Residue file name: F:\Propiconazole\122101 Chronic 11-2010 Sec 3 onion-berry.R98 Adjustment factor #2 used. Analysis Date 11-02-2010/12:43:13 Residue file dated: 11-02-2010/12:40:30/8 Reference dose (RfD, Chronic) = .1 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.006794 6.8%

U.S. Population (spring season) 0.006892 6.9% U.S. Population (summer season) 0.007045 7.0% U.S. Population (autumn season) 0.006504 6.5% U.S. Population (winter season) 0.006748 6.7%

Northeast region 0.007058 7.1% Midwest region 0.006279 6.3% Southern region 0.006073 6.1% Western region 0.008251 8.3%

Hispanics 0.009077 9.1% Non-hispanic whites 0.005989 6.0% Non-hispanic blacks 0.006701 6.7% Non-hisp/non-white/non-black 0.014800 14.8%

All infants (< 1 year) 0.015851 15.9% Nursing infants 0.008277 8.3% Non-nursing infants 0.018726 18.7% Children 1-6 yrs 0.015493 15.5% Children 7-12 yrs 0.009154 9.2%

Females 13-19 (not preg or nursing) 0.005170 5.2% Females 20+ (not preg or nursing) 0.004916 4.9% Females 13-50 yrs 0.005825 5.8% Females 13+ (preg/not nursing) 0.007132 7.1% Females 13+ (nursing) 0.007981 8.0%

Males 13-19 yrs 0.006558 6.6% Males 20+ yrs 0.005588 5.6% Seniors 55+ 0.004487 4.5%

Children 1-2 yrs 0.018210 18.2% Children 3-5 yrs 0.014763 14.8% Children 6-12 yrs 0.009627 9.6% Youth 13-19 yrs 0.005891 5.9% Adults 20-49 yrs 0.005685 5.7% Adults 50+ yrs 0.004556 4.6% Females 13-49 yrs 0.005369 5.4%