SAT Report

PMN Number: P-08-0701

SAT Date: 9/19/2008

Print Date: 1/12/2010

Related cases: CBI: Yes

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 2

 Persistence Bioaccum Toxicity Comments

 3 1 2

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Inhalation and drinking water.

Ecotox: No releases to water

Fate: ;

Keywords:

 Keywords: ONCO, DEVEL, UNCERT-IMMUNO, BLOOD, ALGAL SHADING

Summary of Assessment:

 Fate:

Fate Summary: P-08-0701

FATE: Estimations for neutralized

log Kow = 2.53 (E)

log Koc = 2.58 (E)

log Fish BCF = 0.50 (E)

PMN Substance: Solid with MP = Dec. 345-405 EC (DSC)

S = 47.4 mg/L at 25 EC (M)

VP < 1.0E-6 torr at 25 EC (E)

BP > 400 EC (E)

H < 1.00E-8 (E)

logKoc = -0.18 (M)

POTW removal (%) = 0-50 via sorption; OECD111 (Hydrolysis):

 1.7%(pH4)/0%(pH7)/1.8%(pH9)/6d; OECD301F (Mano Resp): 

0-1%/28d
NRB.

Time for complete ultimate aerobic biodeg > mo

Sorption to soils/sediments = moderate

PBT Potential: P3B1

*CEB FATE: Migration to ground water = moderate

 Health:

 Health Summary: Absorption of the intact compound is nil through the skin 

and GI tract and poor through the lungs based on physical/chemical properties. Expect 

dissociation of the salt in the stomach and in the intestine followed by absorption 

of the products based on analogs. There is a marginal concern for oncogenicity by 

analogy to (also known as - the 

produced an increased incidence of sarcoma of the spleen and a dose-related 

increase in neoplastic nodules of the liver in male F344 rats at 3000 ppm in the diet 

The PMN compound is expected to be less of a concern for oncogenicity than the analog because

the group on the will enhance excretion of the compound. There 

is concern for developmental toxicity and uncertain concern for immunotoxicity for the

 product. A concern for blood effects is also raised by 

analogy to based on the effects on the spleen and hemosiderosis at doses of

600 to 50,000 ppm in the diet. Low moderate concern.

 Test Data: negative in Salmonella and E coli - Prival modification

negative in the mouse lymphoma assay

acute oral study in rats - no deaths at 2000 mg/kg, slight sedation at 2 to 3 hours after dosing

acute dermal study in rats - no deaths at 2000 mg/kg, red staining at site of application

not a dermal sensitizer in the mouse local lymph node assay (10% concentration)

28-day oral study in rats (50, 250, 1000 mg/kg) - no adverse effects seen; NOAEL = 1000 mg/kg

mild eye irritant

mild skin irritant

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 >100

daphnid 48-h LC50 >100

green algal 96-h EC50 20 shading

fish _ chronic value >10

daphnid _ chronic value >10

algal _ chronic value 2.0 shading

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic Value _

Ecotox Values Comments: Predictions are based on SAR-nearest analog method for 

 and indirect effect of algal shading from the 
; SAR chemical class = ; MW 492; solid 

with decomposition prior to melting at 345 C (M); S < 200 mg/L at 20 C, pH 7 (P); 

pH7; effective concentrations based on 100% active ingredients and mean measured 

concentrations; DW hardness < 150.0 mg/L as CaCO3; and DW TOC < 2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

200

SARs

SAR Class

Ecotox Factors Comments: See attachment immediately below for 

revised concern concentration based on test data below. S. Cragg 

 SAT Chair: Becky Jones