Exhibit 10.7



 Exhibit 10.7 

AMENDMENT TO EMPLOYMENT AGREEMENT 

This Amendment (“Amendment”) is entered into effective November 15, 2016 , by and between Chiasma (Israel) Ltd.,
registration number 513104026, a company incorporated in the State of Israel, and Roni Mamluk (“Executive”). 

WHEREAS, the Company and Executive entered into an Employment Agreement dated December 16, 2014 (the “Employment
Agreement”); and 
 WHEREAS, the Company and Executive wish to amend certain provisions of the Employment Agreement. 

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, intending to
be legally bound, the parties hereto agree as follows: 
  

	 	1.	The third sentence of Section 6.2 of the Employment Agreement is hereby deleted in its entirety and replaced with the following: 


“Executive’s Bonus target shall be not less than 40% of Executive’s Salary for 12 months (the “Target
Bonus”).” 
  

	 	2.	Section 9.2 of the Employment Agreement is hereby deleted in its entirety and replaced with the following: 


“If Executive resigns without Good Reason on or before December 15, 2016, then, subject to Executive signing a general release of
known and unknown claims against the Company and its affiliates, in substantially the form attached hereto as Appendix B (the “Release”), within fifteen (15) days following the date of such resignation and Executive’s
continued compliance with her undertakings and obligations under Sections 10 – 12 of this Agreement, (y) all of the stock options held by Executive as of her date of termination will become fully vested and exercisable as of such date and
(z) within thirty (30) days following her date of termination, the Company shall pay Executive (i) a lump-sum amount equal to twelve (12) months of her Salary in effect on the date of
termination, (ii) a lump sum amount equal to the Prior Year Bonus and (iii) any Statutory Severance Amount.” 








	 	3.	The Company’s notice address in Section 11.3 of the Employment Agreement is hereby deleted in its entirety and replaced with the following: 


“If to the Company: 

Chiasma (Israel) Ltd. 
 c/o
Chiasma, Inc. 
 275 Wyman St., Suite 250 

Waltham, MA 02451 
 USA

 Attention: Chief Executive Officer 

with a copy to: 
 Goodwin
Procter LLP 
 10 Northern Avenue 

Boston, MA 02110 
 USA 

Attention: Michael H. Bison” 
  

	 	4.	Except as so amended, the Employment Agreement is in all other respects hereby confirmed and defined terms used but not defined herein shall have the meanings set forth in the Employment Agreement. 


 

	 	5.	This Amendment may be signed and delivered in counterparts, each of which shall be deemed an original and all of which taken together shall constitute one and the same document. The execution and delivery of this
Amendment may be evidenced by a facsimile or electronically. 








 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date
first set forth above. 
  

			
	CHIASMA (ISRAEL) LTD.
		
	By:	 	 /s/ Mark J. Fitzpatrick

	Name:	 	Mark J. Fitzpatrick
	Title:	 	President & CEO
	
	EXECUTIVE
	
	 /s/ Roni Mamluk, Ph.D.

	Roni Mamluk, Ph.D.


  

			
	Chiasma, Inc. hereby guarantees the performance of the Company’s obligations under this Amendment.
	
	CHIASMA, INC.
		
	By:	 	 /s/ Mark J. Fitzpatrick

	Name:	 	Mark J. Fitzpatrick
	Title:	 	President & CEO

 [Signature Page to the Amendment to the Employment Agreement]