"Mara Tellez Rojo" <mmtellez@correo.insp.mx> 02/11/2008 03:36 PM T o Jee - Young

Kim/RTP/USEPA/US@EPA c c <david.bellinger@childrens.harvard.

edu>, Deirdre Murphy/RTP/USEPA/US@EPA, Karen Martin/RTP/USEPA/US@EPA, Mary Ross/RTP/USEPA/US@EPA, Zachary Pekar/RT P/USEPA/US@EPA, <hlamadrid@insp.mx> S u b j e c t RE: Questions on the Tellez - Rojo et

al. (2006) paper

Kim , don't worry ! On the contrary, sorry for the delay ! Here is the information you requested, I hope they may be helpful. Best regards,

n Mi n Ma x p25 Me dian p75 Me an SD

Below 5 m

g/dL Blood Pb 12 mo ( m g/dL) 195 0.5 4.9 2.2 3.1 4.0 3.0 1.1 Blood Pb 24 mo ( m g/dL) 193 0.8 4.9 2.1 2.9 3.7 2.9 1.1

5- 10 m g/dL Blood Pb 12 mo ( m g/dL) 99 5 9.7 5.6 6.5 7.8 6.7 1.4 Blood Pb 24 mo ( m g/dL) 101 5 9.8 5.5 6.7 8.1 6.9 1.4Dirección de Evaluación de Programas y Métodos Cuantitativos,

Centro de Investigación en Evaluación y Encuestas, Instituto Nacional de Salud Pública 52 - 777 - 101 29 31 52 - 777 - 329 30 00 ext 3402 Fax: 52 - 777 - 311 11 48 y 52 - 777 - 311 24 72 De: Kim.Jee - Young@epamail.epa.gov [mailto:Kim.Jee - Young@epamail.epa.gov] Enviado el: lun 11/02/2008 10:58 Para: Mara Tellez Rojo CC: david.bellinger@childrens.harvard.edu; Murphy.Deirdre@epamail.epa.gov; Martin.Karen@ epamail.epa.gov; Ross.Mary@epamail.epa.gov; Pekar.Zachary@epamail.epa.gov Asunto: RE: Questions on the Tellez - Rojo et al. (2006) paper Thank you Dr. Tellez - Rojo! And I apologize for the belated request, but in addition to the mean blood lead levels and the number of children in the less than 5 ug/dL subset, can you also provide us this information for the 5 - 10 ug/dL subset of children? Thanks! Young Jee Young Kim, Sc.D. U.S. Environmental Protection Agency National Center for Environmental Assessment Te lephone: 919 - 541 - 4157 E - ma il: kim.jee - yo ung@epa.gov

"Mara TellezRojo" <mmtellez@correo To .insp.mx> Jee - Young Kim/RTP/USEPA/US@EPA cc 02/09/2008 12:46 <david.bellinger@childrens.harvar AM d.edu>, Mary

Ross/RTP/USEPA/US@EPA, Zachary Pekar/RTP/USEPA/US@EPA, D eirdre Murphy/RTP/USEPA/US@EPA, Karen Martin/RTP/USEPA/US@EPA

Subject RE: Questions on the Tellez - Rojo et al. (2006) paper

Dear Kim, we will send you this information on Monday, for sure! Sorry for the delay!Dirección de Evaluación de Programas y Métodos Cuantitativos,

Centro de Investigación en Evaluación y Encuestas, Instituto Nacional de Salud Pública 52 - 777 - 101 29 31 52 - 777 - 329 30 00 ext 3402 Fax: 52 - 777 - 311 11 48 y 52 - 777 - 311 24 72

De: Kim.Jee - Young@epamail.epa.gov [ mailto:Kim.Jee - Young@epamail.epa.gov ] Enviado el: jue 07/02/2008 15:58 Para: Mara Tellez Rojo CC: david.bellinger@chi ldrens.harvard.edu; Ross.Mary@epamail.epa.gov; Pekar.Zachary@epamail.epa.gov; Murphy.Deirdre@epamail.epa.gov; Martin.Karen@epamail.epa.gov Asunto: RE: Questions on the Tellez - Rojo et al. (2006) paper

Dear Dr. Tellez - Rojo, Thank you for your response. I just wanted to follow - up with you on our request for information on your 2006 paper. Just to clarify, would you please provide us with information regarding the distribution (mean, median, minimum, maximum) of the blood lead levels in the group of children with levels less than 5 ug/dL? As you may be aware, the Pb NAAQS revie w is on a very tightcourt - ordered deadline. We would greatly appreciate your prompt

response. Many thanks, Young Jee Young Kim, Sc.D. U.S. Environmental Protection Agency Nation al Center for Environmental Assessment Telephone: 919 - 541 - 4157 E - ma il: kim.jee - yo ung@epa.gov

"Mara Tellez Rojo" <mmtellez@correo To .insp.mx> J ee - Young Kim/RTP/USEPA/US@EPA,

<david.bellinger@childrens.harvar 01/31/2008 01:36 d.edu> AM cc

Zachary Pekar/RTP/USEPA/US@EPA, Mary Ross/RTP/USEPA/US@EPA, Mary Ross/RTP/USEPA/US@EPA

SubjectRE: Questions on the Tellez - Rojo et al. (2006) paper

Hello Jee - Young Kim, we appreciate very much your attention in our paper. We will work on the information you requested and will go bac k as soon as possible. I will have a tough day tomorrow and Monday is a holiday in Mexico, so I will be able to work on this next week. Is that ok for you? Best regards, Martha Ma. (Mara) Téllez - Rojo Dirección de Evaluación de Programas y Métodos Cuantit ativos, Centro de Investigación en Evaluación y Encuestas, Instituto Nacional de Salud Pública 52 - 777 - 101 29 31 52 - 777 - 329 30 00 ext 3402Fax: 52 - 777 - 311 11 48 y 52 - 777 - 311 24 72

De: Kim.Jee - Young@epamail.epa.gov [ mailto:Kim.Jee - Young@epamail.epa.gov ] Enviado el: mar 29/01/2008 12:30 Para: Mara Tellez Rojo; david.bellinger@childrens.harvard.edu CC: Pekar.Zachary@epamail.epa.gov; Ross.Mary@epamail.epa.gov; Ross.Mary@epamail.epa.gov Asunto: Re: Questions on the Tellez - Rojo et al. (2006) paper

Dear Drs. T ellez - Rojo and Bellinger, I had e - mailed you last month with some questions about your paper and wanted to follow - up with you. As you may be aware, EPA is currently in the process of reviewing the U.S. National Ambient Air Quality Standard for Lead and will be announcing the proposed rule in April/May 2008. The Air Quality Criteria Document for Lead, in which Dr. Bellinger make great contributions, discusses your 2006 paper as one that showed statistically significant associations in infants at blood lead levels below 10 ug/dL. In addition, among the 24 month olds, you also observed statistically significant associations at below 5 ug/dL. Would you be able to provide us with some information regarding the distribution (e.g., mean, median, minimum) of the blood lead levels in this group of children (i.e., less than 5 ug/dL)?We greatly appreciate your help on this matter.

Thanks, Young Jee Young Kim, Sc.D. U.S. Environmental Protection Agency National Center for Environmental Assessment Telephone: 919 - 541 - 4157 E - ma il: kim.jee - yo ung@epa.gov

Jee - Young Kim/RTP/USEPA/US To 12/20/2007 05:17 mmtellez@insp.mx, PM david.bellinger@childrens.harvard

.edu cc Deirdre Murphy/RTP/USEPA/US@EPA, Zachary Pekar/RTP/USEPA/US@EPA, Mary Ross/RTP/USEPA/US@EPA

Subject Questions on the Tellez - Rojo et al. (2006) paperDear Drs. Tellez - Rojo and Bellinger,

We are much interested in your 2006 paper published in Pediatrics that showed cognitive deficits in infants at blood lead levels below 10 ug/dL. In particular, w e were interested in your finding of a greater effect from 0 to 5 ug/dL compared to 5 to 10 ug/dL on MDI in 24 month old children. Can you please provide us with some additional information regarding the distribution of blood lead levels in the subset of children with levels less than 5 ug/dL? For example, what was the mean and minimum blood lead levels for that subset of children? Thank you for taking the time to consider our questions. Happy Holidays! Best, Young (See attached file: Telle z - Rojo et al. (2006).pdf)Jee Young Kim, Sc.D.

U.S. Environmental Protection Agency National Center for Environmental Assessment Telephone: 919 - 541 - 4157 E - ma il: kim.jee - yo ung@epa.gov