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BIGMAR 10-K EXHIBIT NO. 10.44
BIOFERMENT LICENSE



                             CANCELLATION AGREEMENT



entered into between

BIGMAR,  INC.,  a  Delaware  corporation  having its place of  business  at 6660
Doubletree  Avenue #20,  Columbus,  Ohio, 43229 USA,  hereafter  "BIGMAR",  duly
represented by Mr. John Tramontana, president of BIGMAR


and



CERBIOS-PHARMA  SA, a Swiss corporation having its place of business at via Pian
Scairolo 6, 6917 Barbengo, Switzerland, hereafter "CERBIOS", duly represented by
Mr.  Giuseppe  Rovelli,  in  accordance  with  the  Resolution  of the  board of
directors of Cerbios executed on March 25, 1997,  hereto enclosed in original as
Exhibit A.


                                      ***


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                                                                               2

RECITALS


Whereas


a)  on November 14, 1995 Bigmar and the  Bioferment  division  of  Cerbios  have
    entered  into the License and supply  agreement  relating to  pharmaceutical
    products  utilising  or  containing  Urokinase,  Human  Growth  Hormone  and
    Interferon;

b)  on February 29, 1996 Bigmar and the Bioferment  division of Cerbios executed
    an amendment of the above mentioned  agreement of November 14, 1995 relating
    to the license fees;

c)  in November 1996,  according to par. 5.1 of the above mentioned agreement of
    November 14, 1995,  Bigmar paid a first  instalment  of US$100,000 -- of the
    license  fee  of US$500,000 -- due to Cerbios, with value date  November 21,
    1996;

d)  except  from  the  above  mentioned  payment  of  the  first  instalment  of
    US$100,000,  the parties  never  implemented  or  fulfilled  the license and
    supply agreement of November 14, 1995;

e)  the  parties  deem  that it is in their  own best  interest  to close  their
    commercial  relationships  relating  to the  above  mentioned  agreement  of
    November 14, 1995 and its amendment of February 29, 1996,



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                                                                               3


all this aforementioned,
the parties agree as follows:


1.  The parties  agree to cancel and cancel the License and supply  agreement of
    November  14,  1995 as well as its  amendment  of  February  29,  1996  with
    immediate effect.

2.  The first  instalment  of  US$100,000  of  the  license  fee remains for the
    benefit and the account of Cerbios, which therefore is entitled to keep such
    amount, without any obligation to refund it to Bigmar.

3.  With the  execution of the present  Cancellation  agreement  the parties are
    lifted from any and all  obligations  connected  with the License and supply
    agreement  of November  14, 1995 as well as its  amendment  of February  29,
    1996, except from those relating to the  confidentiality  clause (clause X),
    which shall continue to have effect.

4.  The  present  agreement  shall  take  effect and enter into force as soon as
    Bigmar will have  delivered  two originals of the  corresponding  "Unanimous
    written  consent of the board of  directors  of Bigmar,  Inc.",  in the form
    attached hereto as Exhibit B, to the notary public Mr. Pietro Moggi,  who is
    herewith  instructed by the parties to receive such  resolution  and deliver
    one original of this resolution to Cerbios.


    Bigmar undertakes to deliver this resolution to the notary public within the
    10th of April 1997.




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                                                                               4

    In  case  of  failure  to provide  the  "Unanimous  written  consent  of the
    board of  directors  of Bigmar,  Inc."  within the 10th of April  1997,  the
    present  agreement will not come into force and will be considered  null and
    void.

5.  This  agreement  shall be governed by and construed in  accordance  with the
    substantive laws of the State of Delaware, USA, without regard to Delaware's
    choice of law rules.

6.  Any  disputes  or  differences  between  the  parties  arising out of, or in
    connection  with  this  agreement  shall be  resolved  in New York by a sole
    arbitrator,   in  accordance   with  the  rules  and   regulations   of  the
    International Chamber of Commerce of Paris.

In witness whereof,  both parties have caused this agreement to be signed in six
originals, two for each party and two for the notary public, by their respective
duly authorised officers or representatives on the date indicated below.


Lugano, 27th of March 1997






BIGMAR, INC.                              CERBIOS-PHARMA SA


By:                                       By:
 Name:  John Tramontana                      Name:  Giuseppe Rovelli
 Title: President                            Title: Officer



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                                                          EXHIBIT A - BIOFERMENT
                                                                      LICENSE


                                    VERBALE
                        DEL CONSIGLIO DI AMMINISTRAZIONE
                                     DELLA

                          CERBIOS-PHARMA SA, BARBENGO


La riunione del consiglio e tenuta a Barbengo, negli uffici della Cerbios-Pharma
SA, che dopo discussione ha adottato le seguenti risoluzioni:

1.  e approvata la sottoscrizione  della convenzione con Bigmar, Inc., Columbus,
    Ohio, relativa alla risoluzione del contratto "License and supply agreement"
    stipulato   il  14   novembre   1995  tra  la  divisone   Bioferment   della
    Cerbios-Pharma  e  la  Bigmar,  Inc.;  e  parimenti  annullata  la  modifica
    contrattuale del 29 febbraio 1996;

2.  e  conferito   mandata  al  signor  Giuseppe  Rovelli  par  la  firma  della
    convenzione con Bigmar, Inc.


Lugano, 25 marzo 1997



            [SIGNATURE]                       [SIGNATURE]

--------------------------------        -----------------------------
ING. ATTILIO MELERA                     JAN JACOB VAN TROOSTENBURG





            [SIGNATURE]  

-------------------------------- 
PIERANGELO GHIRLANDA




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TRANSLATION OF EXHIBIT A - BIOFERMENT LICENSE
BY PAUL VESPOLI - OSU (OHIO STATE UNIVERSITY)



                                    Minutes
                           of the Board of Directors
                                       of

                         Cerbios-Pharma Inc., Barbengo



The meeting of the Board of Directors  was held in  Barbengo,  at the offices of
Cerbios-Pharma, Inc., and after discussion adopted the following resolutions:

1. The  subscription to the convention  with Bigmar,  Inc.,  Columbus,  Ohio was
approved according to the resolution of the "License supply agreement"  contract
drafted 14 November  1995 between the  Bioferment  division of Cerbios Phama and
Bigmar Inc.; the contractual amendment of 29 February 1996 was also nullified.

2. Mr.  Giuseppe  Rovelli was given  power-of-attorney  for the convention  with
Bigmar, Inc.

Lugano, 25 March 1997




(signature)                         (signature)
Engineer Attilio Melera             Jan Jacob Van Troostenburg




(signature)
Pierangelo Ghirlanda






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                                                                       EXHIBIT B


                           UNANIMOUS WRITTEN CONSENT
                                       OF
                             THE BOARD OF DIRECTORS
                                       OF
                                  BIGMAR, INC.


The  undersigned,  being all of the  Directors of BIGMAR,  INC.,  a  corporation
organised and existing under the laws of the State of Delaware  (the "Company"),
do  hereby  consent,   pursuant  to  Section  141(f)  of  the  Delaware  General
Corporation  Law and Section 15 of the Restated  Bylaws of the  Company,  to the
adoption without a meeting of the following  resolutions and that this action be
taken without a meeting  pursuant to said Section 141(f) of the Delaware General
Corporation Law and Section 141(f) of the Delaware  General  Corporation Law and
Section 15 of the Restated Bylaws of the Company:

Whereas,  Mr.  John  Tramontana  has  disclosed  to the Board of  Directors  his
interests and willingness in the  cancellation of the  Distribution  and License
Agreements (defined below);

Whereas, a majority of the disinterested directors of the Company has determined
that the cancellation of the (i) Exclusive  Distribution  and Supply  Agreement,
dated  November 14, 1995,  between the Company and the SAPEC Division of Cerbios
Pharma SA ("Sapec"), (ii) License and Supply Agreement, dated November 14, 1995,
between  the  Company  and   Bioferment,   a  division  of  Cerbios   Pharma  SA
("Bioferment")  and (iii) Exclusive  Distribution  and Supply  Agreement,  dated
December  14,  1995,  between  the  Company and  Bioferment  (collectively,  the
"Distribution and License  Agreements"),  is desirable and in the best interests
of the Company; and

Whereas, the Cancellation  Agreements have already been signed on March 27, 1997
by Cerbios-Pharma SA and by Mr. John Tramontana, in his capacity of president of
Bigmar,  Inc., on behalf of Bigmar,  Inc., a copy of which is attached hereto as
Exhibit A, B and C; and

Whereas,  Mr. John Tramontana has given to the Board of Directors an original of
each of the above three Cancellation Agreements, which correspond in full to the
Exhibits A, B and C; and

Whereas, a majority of the disinterested directors of the Company has determined
that the above Cancellation Agreements, which effect the cancellation of each of
the Distribution and License  Agreements are desirable and in the best interests
of the Company.


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NOW, THEREFORE,  BE IT RESOLVED, that the Cancellation Agreements be, and hereby
are, approved, authorized, ratified and adopted in all respects; and be it

FURTHER RESOLVED, that the execution and delivery of the Cancellation Agreements
by the President  Mr. John  Tramontana  is the  enforceable  and binding act and
obligation  of the Company,  without the signature or  attestation  of any other
officer of the Company or the affixing of any corporate seal; and be it

FURTHER RESOLVED,  that any and all actions heretofore or hereafter taken within
the terms of the foregoing  resolutions be, and hereby are,  affirmed,  approved
and ratified as the act and deed of the Company.

This Unanimous Written Consent may be executed in multiple counterparts, each of
which shall  constitute  an original and all of which shall  constitute a single
document.

IN WITNESS WHEREOF, the undersigned have executed this Unanimous Written Consent
on                  ,  1997 and  directed  that it be filed with the  minutes of
proceedings of the Board of Directors.


                                              /s/ JOHN G. TRAMONTANA
                                              ----------------------
                                              JOHN G. TRAMONTANA



                                              ----------------------
                                              MICHAEL K. MEDORS



                                              ----------------------
                                              BERNARD KRAMER



                                              ----------------------
                                              ERIC M. CHEN



                                              ----------------------
                                              JOHN MORRIS

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