Dicrotophos Dietary Exposure and Risk Assessment DP No: D428508 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

Date: September 15, 20 15 

SUBJECT: Dicrotophos: Revised Acute and Steady State Aggregate Dietary (Food and 

Drinking Water) Exposure and Risk Assessments to Support Registration Review 

PC Code: 03520 I 

Decision No.: 454409 

Petition No.: NA 

DP Ba rcode: 0428508 

Registration No.: NA 

Regulatory Action: Registration Review 

Risk Assessment Type: Dietary Case No.: 0 145 

TXR No.: NA CAS No.: 14 1-66-2 

MRID No.: NA 

FROM: 

THROUGH: 

TO: 

Thur

Risk 

ston 

Assessm

Morton

ent 

, 

Branch 

Chemist 

IV ~r;:/;/ Health Effects Division (7509P) 

Sheila Piper, Chemist cSiJc.__. ~~ Julie VanAlstine, Chemist ~· 

Dietary Exposure Science Advisory Council 

Ri

harl sk Assessmee~~ith, nt Branch 

Branch 

Chi

lV

ef 

, HED 

C 

(7509P) 

~ 

Khue Nguyen 

Risk Management and Implementation Branch l 

Pesticide Re-evaluation Division (7508P) 

Executive Summary 

Acute and steady state aggregate dietary food and drinking water exposure and risk assessments 

for dicrotophos were conducted using the Dietary Exposure Evaluation Model software with the 

Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 

food consumption data from the U.S. Department of Agriculture's (USDA's) National Health 

and Nutrition Examination Survey, What We Eat in America, (NHANES!WWEIA). This 

dietary analysis is updated to reflect the use of the 2-day average option in DEEM for the steady 

state dietary assessment. In addition, the FQPA safety factor (1 OX) will be retained for infants, 

children, youths, and women of child-bearing age for these exposure scenarios to account for 

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uncertainties introduced by the lack of sufficient data to quantify potential neurodevelopmental 

effects. 

This memorandum was reviewed by two peer reviewers of the DESAC per the current DESAC 

Standard Operating Procedure (SOP). 

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization 

Dicrotophos is a broad spectrum organophosphate insecticide. The only dicrotophos end-use 

formulation currently registered is a water-miscible formulation which may be foliarly applied to 

established cotton plants or used as a tree injection treatment for ornamental and non-food 

producing trees. 

A refined acute dietary exposure assessment was conducted to estimate the dietary exposure and 

risk associated with registration review. The acute dietary exposure assessment incorporated 

average field trial residue, 100% crop treated, and the entire distribution of estimated drinking 

water concentrations (EDWCs) for the acute analysis. The drinking water concentrations were 

based on the use of dicrotophos from three cotton scenarios. 

The acute aggregate dietary exposure estimates are below HED's level of concern ( <l 00 % the 

acute population adjusted dose (aP AD)) for the U.S. population and all population subgroups for 

all but one water scenario (NC Cotton Max Rate). Combined dietary exposure from food and 

drinking water at the 95'11 percentile of exposure ranged from 11-50% of the aPAD for the U.S. 

population and 19-130% of the aPAD for all infants <1 year old), the most highly exposed 

population subgroup. The dietary exposure estimates for food only were :511 % aPAD for all 

population subgroups. 

Two-Day Average Dietary (Food and Drinking Water) Exposure Results and Characterization 

OPs may exhibit a phenomenon known as steady-state acetylcholinesterase (AChE) inhibition, 

which is the most sensitive endpoint for all lifestages. After repeated dosing at the same dose, 

the amount of AChE inhibition in a given dose remains consistent across duration. For this 

reason, a steady-state point of departure (POD) was selected for oral exposure to dicrotophos. 

The DEEM acute module was used to conduct refined two-day (steady-state) average 

assessments using the steady-state endpoint and 21-day forward-rolli ng water averages. These 

two-day average assessments estimate 21-day ("steady-state") average daily food and drinking 

water exposures. The same drinking water scenarios were provided by EFED for use in the twoday average analyses. The drinking water distributions provided by EFED were converted into 

distributions of 2 1-day forward-rolling averages for the two-day average assessments. A 

discussion of how the 2 1-day forward-rolling averages were calculated can be found in Section 

V . 

The food only steady-state results do not exceed HED's LOC (<100% of the steady-state 

population-adjusted dose (ssPAD)) for the U.S. population and a ll population subgroups at the 

95111 percentile. The U.S. population utilized 10% of the ssPAD and children 3-5 years old, the 

Page 2 of28 
Page 3 of 28

most highly exposed population subgroup, utilized 23% of the ssPAD. For the two-day 

average 

The steady state (2 day average) aggregate dietary (food and drinking water) exposure estimates 

using DEEM-FCID with the 2-day average option are above HED’s level of concern for all 

maximum application rate cotton water scenarios. Combined dietary exposure from food and 

drinking water at the 95th percentile of exposure ranged from 10-52% of the ssPAD for the U.S. 

population and 50-320% of the ssPAD for all infants <1 year old). All typical application rate 

(as determined by BEAD) cotton scenarios gave aggregate dietary (food and drinking water) 

exposure estimates <100% ssPAD. The dietary exposure estimates for food only were ≤23% 

ssPAD for all population subgroups.

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization 

Dicrotophos is classified as showing "Suggestive evidence of carcinogenicity, but not sufficient 

to assess human carcinogenic potential”. Quantitative risk assessment for dicrotophos using the 

Reference Dose (RfD) approach will adequately account for all chronic toxic effects, including 

carcinogenicity.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For the 

acute and two-day average assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse 

health effects). This dose is referred to as the PAD. The PAD is equivalent to the point of 

departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and two-day average assessments, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss dietary risk assessments in more detail are 

available on the EPA/pesticides web site: “Available Information on Assessing Exposure from 

Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The two-day average assessments were conducted in the DEEM acute module using the steadystate endpoint and 21-day forward-rolling water averages to provide an estimate of 21-day 

(“steady-state”) average daily exposures. These two-day average assessments were completed 

for food alone and food and drinking water. For the two-day average assessments, using a 21-

day forward-rolling average water file, provide an accurate overall estimate of the 21-day 

(“steady-state”) average daily exposures at the per-capita 95th percentile for drinking water, to 

the extent that predicted drinking water concentrations for any 21-day duration is known for any 

given year. For food alone, the two-day average assessments reflect an average daily exposure 

for a two-day exposure duration rather than a 21-day exposure duration. Since the DEEM twoday average assessment does not capture day-to-day variation in food residues, it will generally 

result in higher food-only exposure estimates than a model that calculates 21-day rolling 

averages for food. Although the DEEM two-day average assessments may result in higher 

exposure estimates for food, the assessments provide a reasonable estimate of 21-day (“steady-
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state”) average daily exposure for food and drinking water for use in risk assessment. 

 

The most recent dietary risk assessment for dicrotophos was conducted by T. Morton (July 10, 

2014, D418103).

II. Residue Information

Dicrotophos (dimethyl phosphate of 3-hydroxy-N,N-dimethyl-cis-crotonamide) is a contact, 

systemic acaricide/insecticide registered for use on cotton. Permanent tolerances are established 

for the residues of dicrotophos and monocrotophos at 0.20 ppm in cotton, undelinted seed and at 

2.0 ppm in cotton gin byproducts (40CFR §180.299). 

The residues of concern in plants are dicrotophos and monocrotophos.

Residue Data used for Acute and Steady state Dietary Assessments

A refined acute dietary exposure assessment was conducted using average field trial residues and

100% crop treated. 

The USDA Pesticide Data Program (PDP) monitored for dicrotophos pesticide residues in catfish 

in 2008. PDP analyzed 552 samples of catfish for dicrotophos residues. None of the samples 

contained detectable residues. As a result, residues in fish were not included in the assessment.

III. Percent Crop Treated Information

The acute and steady state aggregate dietary analyses were performed assuming 100% of each 

commodity was treated with dicrotophos.

IV. Drinking Water Data

This assessment uses maximum rates but considers typical rates. The assessment considers a 

parent only approach but also considers the major degradates as parent in a total toxic residue 

(TTR) approach. Toxicity data and acceptable environmental fate data is unavailable for 

dicrotophos degradates. Inclusion of the TTR approach is provided for a complete 

characterization of EDWCs. 

Daily time series outputs for the thirty year simulation were provided to HED for use in dietary 

exposure modeling (A. Shelby, D427440, 8/13/15).
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Table 5.3. Summary of Estimated Surface Water and Groundwater Concentrations for 

Dicrotophos.

SWCC 

Scenario

Application rate 

and timing

1-in-10-year 

peak (ppb)

1-in-10-year 21 

day average 

(ppb)

1-in-10-year 

annual average 

(ppb)

Simulation 

average 

(ppb)

Mississippi 

Cotton

Maximum Rate 6.09 4.01 0.381 0.199

Typical Rate -

BEAD dates

3.21 1.67 0.193 0.0860

Typical Rate - 14 

day interval

4.49 2.45 0.204 0.0834

North 

Carolina 

Cotton

Maximum Rate 7.73 4.94 0.507 0.306

Typical Rate 1.62 1.05 0.0901 0.0503

Texas 

Cotton

Maximum Rate 8.75 4.63 0.430 0.222

Typical Rate -

BEAD dates

3.66 2.12 0.238 0.0934

Typical Rate - 14 

day interval

3.69 2.09 0.217 0.0839

V. DEEM-FCID Program and Consumption Information

A dicrotophos acute and steady state (2-day average) dietary exposure assessment was conducted 

using the DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from 

USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption 

data are averaged for the entire U.S. population and within population subgroups. However, for 

acute exposure assessment, consumption data are retained as individual consumption events. 

Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary 

patterns and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99

years old.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.
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For the steady-state (acute 2-day average) exposure assessment, 2-day average food 

consumptions are calculated on an individual-by-individual basis. The reported consumption 

amounts of each food item for each day are added together and then divided by two (2) days. 

For example, if an individual reports eating 100 grams of apple on the first day and 0 grams of 

apple on the second day, the 2-day average consumption amount would be 50 grams/day of apple 

[(100 grams + 0 grams)/2-days = 50 grams/day]. The resulting 2-day average consumption 

amount can then be multiplied by a residue point estimate and summed to obtain a total daily 

pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The resulting 

distribution of exposures is expressed as a percentage of the PAD on both a user (i.e., only those 

who reported eating relevant commodities/food forms) and per-capita (i.e., those who reported 

eating the relevant commodities as well as those who did not) basis. In accordance with HED 

policy, per capita exposure and risk are reported for analyses performed at all levels of 

refinement. However, for deterministic assessments, any significant differences in user vs. per 

capita exposure and risk are specifically identified and noted in the risk assessment. 

VI. Toxicological Information

Dicrotophos is a member of the organophosphate (OP) class of pesticides. Like other OPs, the 

initiating event in the adverse outcome pathway (AOP), also often called the mode of action 

(MOA), for dicrotophos involves inhibition of the enzyme acetylcholinesterase (AChE) via 

phosphorylation of the serine residue at the active site of the enzyme. This inhibition leads to 

accumulation of acetylcholine and ultimately to neurotoxicity in the central and/or peripheral 

nervous system. For dicrotophos, AChE inhibition is the most sensitive endpoint in the 

toxicology database in multiple species, durations, lifestages, and routes. AChE inhibition is the 

focus of this hazard characterization; the availability of reliable AChE inhibition dose response 

data is one of the key determinants in evaluating the toxicology database. Some OPs require 

metabolic activation to the oxon metabolite. However, dicrotophos is not one of these OPs. 

Instead, dicrotophos as the parent active ingredient is a ChE-inhibiting chemical.

In general, OPs reach steady state within 2-3 weeks but this can vary among OPs. In the case of 

dicrotophos, the results show a clear pattern of steady state reached at or near 15 days of 

exposure. In addition to the consistency across durations, the data across multiple studies (repeat 

CCA study, gestational data from the DNT, subchronic neurotoxicity study, and subchronic rat 

toxicity study) are similar. Although the durations of the toxicity and exposure assessments may 

differ, an exact match is not necessary and would suggest a level of precision that the toxicity

data do not support. Furthermore, humans would be expected to be slower and closer to the 

typical 2-3 week window of duration. Given this, the 21-day and longer exposure assessment is 

scientifically supportable and also provides consistency across the OPs. Given the results in 

Table 3, for dicrotophos, acute (single day) and steady state durations are appropriate for human 

health risk assessment. 

HED’s ToxSAC met (07/18/2013) to consider the endpoints of toxicological concern for the

dietary exposure. The FQPA 10X Safety Factor will be retained for infants, children, youths, 

and women of childbearing age for all exposure scenarios. Therefore, the dietary exposure 

results for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, 
Page 7 of 28

children 6-12, youth 13-19, females 13-49, and adults 20-49 will include an 10x FQPA SF with 

the exception of adults 50-99 years (T. Morton, D428506, 9/15/15). 

Table 3. Summary of Toxicological Doses and Endpoints for Dicrotophos for use in Human Health 

Risk Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/ 

FQPA 

Safety 

Factors

RfD, PAD, Level 

of Concern for 

Risk Assessment

Study and Toxicological 

Effects

Acute Dietary 

(all populations, 

including 

females 13-49

except for Adults 

50-99)

BMDL10 = 

0.07mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 

10x

Acute PAD = 

0.00007 

mg/kg/day 

CCA Study (MRID 4615205) 

in the rat – PND 8, 15, & 22 

Inhibition of brain ChE in 

male and female rat pups.

Acute Dietary 

(Adults 50-99)

BMDL10 = 

0.07mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 

1x

Acute PAD = 

0.0007 

mg/kg/day 

CCA Study (MRID 4615205) 

in the rat – PND 8, 15, & 22 

Inhibition of brain ChE in 

male and female rat pups.

Steady-State 

Dietary (all 

populations

except for Adults 

50-99)

BMDL10 = 

0.03 

mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 

10x

Steady State PAD 

= 0.00003 

mg/kg/day

Subchronic and chronic 

toxicity studies (OP CRA 

2002, 2006; MRID’s 

43980201 and 44527802)

Inhibition of brain ChE in 

adult rat

Steady-State 

Dietary (adults 

50-99)

BMDL10 = 

0.03 

mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 

1x

Steady State PAD 

= 0.0003 

mg/kg/day

Subchronic and chronic 

toxicity studies (OP CRA 

2002, 2006; MRID’s 

43980201 and 44527802)

Inhibition of brain ChE in 

adult rat

Cancer (oral, 

dermal, 

inhalation)

Classification: "Suggestive evidence of carcinogenicity, but not sufficient to assess 

human carcinogenic potential”.

Point of Departure (PoD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. BMDL10= benchmark dose lower limit for 10% response. UFA = extrapolation from animal to human 

(interspecies). UFH = potential variation in sensitivity among members of the human population (intraspecies). 

FQPA SF = FQPA Safety Factor. RfD = reference dose. 

VII. Results/Discussion 

As stated above, for acute and steady state assessments, HED are concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in tables below are for the 
Page 8 of 28

general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, females 13-49, adults 20-49, and adults 50-99 years. 

The acute aggregate dietary exposure estimates are below HED’s level of concern (<100 % the 

acute population adjusted dose (aPAD)) for the U.S. population and all population subgroups for 

all but one water scenario (NC Cotton Max Rate). Combined dietary exposure from food and 

drinking water at the 95th percentile of exposure ranged from 11-50% of the aPAD for the U.S. 

population and 19-130% of the aPAD for all infants <1 year old), the most highly exposed 

population subgroup. The dietary exposure estimates for food only were ≤11% aPAD for all 

population subgroups.

The steady state (2 day average) aggregate dietary (food and drinking water) exposure estimates 

using DEEM-FCID with the 2-day average option are above HED’s level of concern for all 

maximum application rate cotton water scenarios. Combined dietary exposure from food and 

drinking water at the 95th percentile of exposure ranged from 10-52% of the ssPAD for the U.S. 

population and 50-320% of the ssPAD for all infants <1 year old). All typical application rate 

(as determined by BEAD) cotton scenarios gave aggregate dietary (food and drinking water) 

exposure estimates <100% ssPAD. The dietary exposure estimates for food only were ≤23% 

ssPAD for all population subgroups.

Acute Dietary Exposure Analyses

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food Only) 

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000004 5.7

All Infants (< 1 year old) 0.00007 0.000002 2.6

Children 1-2 years old 0.00007 0.000008 11

Children 3-5 years old 0.00007 0.000008 11

Children 6-12 years old 0.00007 0.000006 8.2

Youth 13-19 years old 0.00007 0.000004 5.1

Adults 20-49 years old 0.00007 0.000002 3.4

Adults 50-99 years old 0.0007 0.000002 <1

Females 13-49 years old 0.00007 0.000002 3.5

* The values for the highest exposed population is bolded.
Page 9 of 28

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Typical Rate

– BEAD Date

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000011 15

All Infants (< 1 year old) 0.00007 0.000024 35

Children 1-2 years old 0.00007 0.000017 25

Children 3-5 years old 0.00007 0.000016 23

Children 6-12 years old 0.00007 0.000012 17

Youth 13-19 years old 0.00007 0.000009 12

Adults 20-49 years old 0.00007 0.000010 15

Adults 50-99 years old 0.0007 0.000010 1.4

Females 13-49 years old 0.00007 0.000010 14

* The values for the highest exposed population is bolded.

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Typical Rate

– 14 DI

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000010 14

All Infants (< 1 year old) 0.00007 0.000020 29

Children 1-2 years old 0.00007 0.000016 23

Children 3-5 years old 0.00007 0.000015 21

Children 6-12 years old 0.00007 0.000011 16

Youth 13-19 years old 0.00007 0.000008 11

Adults 20-49 years old 0.00007 0.000009 13

Adults 50-99 years old 0.0007 0.000009 1.3

Females 13-49 years old 0.00007 0.000009 13

* The values for the highest exposed population is bolded.
Page 10 of 28

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Max Rate

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000020 29

All Infants (< 1 year old) 0.00007 0.000049 70

Children 1-2 years old 0.00007 0.000030 43

Children 3-5 years old 0.00007 0.000027 38

Children 6-12 years old 0.00007 0.000019 28

Youth 13-19 years old 0.00007 0.000015 22

Adults 20-49 years old 0.00007 0.000020 28

Adults 50-99 years old 0.0007 0.000019 2.8

Females 13-49 years old 0.00007 0.000020 28

* The values for the highest exposed population is bolded.

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Typical Rate

– BEAD Date

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000010 15

All Infants (< 1 year old) 0.00007 0.000023 32

Children 1-2 years old 0.00007 0.000017 24

Children 3-5 years old 0.00007 0.000016 23

Children 6-12 years old 0.00007 0.000012 17

Youth 13-19 years old 0.00007 0.000008 12

Adults 20-49 years old 0.00007 0.000010 14

Adults 50-99 years old 0.0007 0.000009 1.3

Females 13-49 years old 0.00007 0.000010 14

* The values for the highest exposed population is bolded.
Page 11 of 28

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Typical Rate

– 14 DI

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000010 14

All Infants (< 1 year old) 0.00007 0.000021 30

Children 1-2 years old 0.00007 0.000016 23

Children 3-5 years old 0.00007 0.000015 21

Children 6-12 years old 0.00007 0.000011 16

Youth 13-19 years old 0.00007 0.000008 11

Adults 20-49 years old 0.00007 0.000009 13

Adults 50-99 years old 0.0007 0.000009 1.2

Females 13-49 years old 0.00007 0.000009 13

* The values for the highest exposed population is bolded.

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Max Rate

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000022 31

All Infants (< 1 year old) 0.00007 0.000053 76

Children 1-2 years old 0.00007 0.000033 47

Children 3-5 years old 0.00007 0.000029 41

Children 6-12 years old 0.00007 0.000021 30

Youth 13-19 years old 0.00007 0.000016 24

Adults 20-49 years old 0.00007 0.000021 30

Adults 50-99 years old 0.0007 0.000021 3.0

Females 13-49 years old 0.00007 0.000021 30

* The values for the highest exposed population is bolded.
Page 12 of 28

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) NC Cotton Typical Rate

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000008 11

All Infants (< 1 year old) 0.00007 0.000013 19

Children 1-2 years old 0.00007 0.000013 18

Children 3-5 years old 0.00007 0.000012 18

Children 6-12 years old 0.00007 0.000009 13

Youth 13-19 years old 0.00007 0.000006 9.2

Adults 20-49 years old 0.00007 0.000007 9.9

Adults 50-99 years old 0.0007 0.000006 <1

Females 13-49 years old 0.00007 0.000007 9.7

* The values for the highest exposed population is bolded.

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) NC Cotton Max Rate

Population Subgroup aPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00007 0.000035 50

All Infants (< 1 year old) 0.00007 0.000092 130

Children 1-2 years old 0.00007 0.000052 75

Children 3-5 years old 0.00007 0.000046 66

Children 6-12 years old 0.00007 0.000033 48

Youth 13-19 years old 0.00007 0.000026 38

Adults 20-49 years old 0.00007 0.000035 50

Adults 50-99 years old 0.0007 0.000035 5.0

Females 13-49 years old 0.00007 0.000035 50

* The values for the highest exposed population is bolded.
Page 13 of 28

Steady State Dietary Exposure Analyses

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food Only)

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000003 10

All Infants (< 1 year old) 0.00003 0.000002 5.9

Children 1-2 years old 0.00003 0.000007 22

Children 3-5 years old 0.00003 0.000007 23

Children 6-12 years old 0.00003 0.000005 17

Youth 13-19 years old 0.00003 0.000003 11

Adults 20-49 years old 0.00003 0.000002 7.3

Adults 50-99 years old 0.0003 0.000002 <1

Females 13-49 years old 0.00003 0.000002 7.5

* The values for the highest exposed population is bolded.

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton 

Typical Rate – BEAD Date

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000011 16

All Infants (< 1 year old) 0.00003 0.000025 83

Children 1-2 years old 0.00003 0.000017 58

Children 3-5 years old 0.00003 0.000016 52

Children 6-12 years old 0.00003 0.000012 39

Youth 13-19 years old 0.00003 0.000009 29

Adults 20-49 years old 0.00003 0.000010 35

Adults 50-99 years old 0.0003 0.000010 3.3

Females 13-49 years old 0.00003 0.000010 34

* The values for the highest exposed population is bolded.
Page 14 of 28

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton 

Typical Rate–14 DI

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000010 14

All Infants (< 1 year old) 0.00003 0.000022 72

Children 1-2 years old 0.00003 0.000016 53

Children 3-5 years old 0.00003 0.000015 48

Children 6-12 years old 0.00003 0.000011 36

Youth 13-19 years old 0.00003 0.000008 27

Adults 20-49 years old 0.00003 0.000010 32

Adults 50-99 years old 0.0003 0.000009 3.0

Females 13-49 years old 0.00003 0.000009 31

* The values for the highest exposed population is bolded.

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Max 

Rate

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000021 30

All Infants (< 1 year old) 0.00003 0.000053 180

Children 1-2 years old 0.00003 0.000032 110

Children 3-5 years old 0.00003 0.000028 94

Children 6-12 years old 0.00003 0.000020 68

Youth 13-19 years old 0.00003 0.000016 53

Adults 20-49 years old 0.00003 0.000021 68

Adults 50-99 years old 0.0003 0.000020 6.6

Females 13-49 years old 0.00003 0.000020 68

* The values for the highest exposed population is bolded.
Page 15 of 28

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton 

Typical Rate – BEAD Date

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000011 15

All Infants (< 1 year old) 0.00003 0.000023 78

Children 1-2 years old 0.00003 0.000017 56

Children 3-5 years old 0.00003 0.000015 51

Children 6-12 years old 0.00003 0.000011 38

Youth 13-19 years old 0.00003 0.000008 28

Adults 20-49 years old 0.00003 0.000010 33

Adults 50-99 years old 0.0003 0.000009 3.2

Females 13-49 years old 0.00003 0.000010 33

* The values for the highest exposed population is bolded.

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton 

Typical Rate–14 DI

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000010 14

All Infants (< 1 year old) 0.00003 0.000022 74

Children 1-2 years old 0.00003 0.000016 53

Children 3-5 years old 0.00003 0.000015 49

Children 6-12 years old 0.00003 0.000011 36

Youth 13-19 years old 0.00003 0.000008 27

Adults 20-49 years old 0.00003 0.000010 32

Adults 50-99 years old 0.0003 0.000009 3.0

Females 13-49 years old 0.00003 0.000009 31

* The values for the highest exposed population is bolded.
Page 16 of 28

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Max 

Rate

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000022 32

All Infants (< 1 year old) 0.00003 0.000057 190

Children 1-2 years old 0.00003 0.000034 110

Children 3-5 years old 0.00003 0.000030 100

Children 6-12 years old 0.00003 0.000022 73

Youth 13-19 years old 0.00003 0.000017 57

Adults 20-49 years old 0.00003 0.000022 73

Adults 50-99 years old 0.0003 0.000021 7.1

Females 13-49 years old 0.00003 0.000022 73

* The values for the highest exposed population is bolded.

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) NC Cotton 

Typical Rate

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000008 11

All Infants (< 1 year old) 0.00003 0.000015 50

Children 1-2 years old 0.00003 0.000013 43

Children 3-5 years old 0.00003 0.000012 40

Children 6-12 years old 0.00003 0.000009 30

Youth 13-19 years old 0.00003 0.000006 21

Adults 20-49 years old 0.00003 0.000007 24

Adults 50-99 years old 0.0003 0.000007 2.2

Females 13-49 years old 0.00003 0.000007 23

* The values for the highest exposed population is bolded.
Page 17 of 28

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) NC Cotton Max 

Rate

Population Subgroup ssPAD (mkd)

95th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.00003 0.000036 52

All Infants (< 1 year old) 0.00003 0.000097 320

Children 1-2 years old 0.00003 0.000053 180

Children 3-5 years old 0.00003 0.000046 150

Children 6-12 years old 0.00003 0.000033 110

Youth 13-19 years old 0.00003 0.000027 90

Adults 20-49 years old 0.00003 0.000036 120

Adults 50-99 years old 0.0003 0.000036 12

Females 13-49 years old 0.00003 0.000036 120

* The values for the highest exposed population is bolded.

VIII. Characterization of Inputs/Outputs

HED has conducted refined acute and steady state dietary risk assessments for dicrotophos. OPs 

exhibit a phenomenon known as steady state AChE inhibition and for coumaphos a steady state 

endpoint was selected. Although, there are rat data at a shorter time period (i.e., 15 days) than 21 

days, exposure assessments of 21 days and longer were conducted for all routes of exposure (i.e., 

oral, dermal and inhalation) for all single chemical OP assessments using Calendex. Given this, 

the 21-day and longer exposure assessment is scientifically supportable and also provides 

consistency across the OPs.

IX. Conclusions

These refined analyses demonstrate that the registered uses for dicrotophos will result in acute 

dietary risk estimates that exceed HED’s level of concern for one drinking water scenario. In 

addition, the steady state dietary exposure estimates are above HED’s level of concern for the 

U.S. population and all population subgroups for all maximum cotton application rate drinking 

water scenarios. 

X. List of Attachments

Attachment 1: Example Acute (Food + Drinking Water) Residue Input File

Attachment 2: Acute (Food + Drinking Water) Results File

Attachment 3: Steady State (Food + Drinking Water) Results File 
Page 18 of 28

Attachment 1: Example Acute (Food + Drinking Water) Residue Input File

Filename: C:\Users\tmorton\Documents\My Files\DEEM Files\035201 Dicrotophos\2013 Working Files 

USE THESE\New Time Series After Amvac Comments 7-2015\035201 Acute MScotton-maxrateBEADstartdate.R08

Chemical: Dicrotophos

RfD(Chronic): .0003 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0007 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 08-17-2015/15:07:51 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

 # Code 

----- ---- ------------ -------- -------- -------

 1 6 DrinkingWaterDicrotophosMScotton-maxrate-BEADstartdate.rdf

 EPA Crop Commodity Name Def Res Adj.Factors RDLComment

 Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

2003128000 20C Cottonseed, oil 0.043000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.043000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.012600 1.000 1.000 1 

8602000000 86B Water, indirect, all sources 0.012600 1.000 1.000 1 
Page 19 of 28

Attachment 2: Acute (Food + Drinking Water) Results File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute TXcotton-maxrate-BEADstartdate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:17:02 Residue file dated: 08-17-2015/15:09:27

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000022 3.08 0.000074 10.58 0.000289 41.34 

All Infants:

 0.000053 75.90 0.000205 292.56 0.000903 1289.94 

Children 1-2:

 0.000033 46.94 0.000109 156.22 0.000436 623.35 

Children 3-5:

 0.000029 41.10 0.000094 133.68 0.000355 506.91 

Children 6-12:

 0.000021 30.08 0.000068 97.31 0.000266 380.34 

Youth 13-19:

 0.000016 23.51 0.000056 79.97 0.000225 321.01 

Adults 20-49:

 0.000021 30.46 0.000073 104.16 0.000284 406.32 

Adults 50-99:

 0.000021 2.97 0.000071 10.08 0.000267 38.12 

Female 13-49:

 0.000021 30.25 0.000073 103.92 0.000287 409.43 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute TXcotton-typrate-BEADdate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:35:13 Residue file dated: 08-17-2015/15:10:02

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000010 1.48 0.000033 4.70 0.000110 15.71 

All Infants:

 0.000023 32.29 0.000088 125.90 0.000328 467.93 

Children 1-2:

 0.000017 24.23 0.000053 75.11 0.000165 236.27 

Children 3-5:

 0.000016 22.58 0.000046 65.85 0.000138 197.71 

Children 6-12:

 0.000012 16.57 0.000035 50.50 0.000103 146.64 

Youth 13-19:

 0.000008 11.84 0.000026 37.47 0.000086 122.87 

Adults 20-49:

 0.000010 14.05 0.000032 45.56 0.000106 151.29 

Adults 50-99:

 0.000009 1.32 0.000030 4.30 0.000099 14.15 
Page 20 of 28

Female 13-49:

 0.000010 13.83 0.000031 44.74 0.000107 152.31 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute TXcotton-typrate-14DI.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:31:02 Residue file dated: 08-17-2015/15:09:44

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000010 1.40 0.000031 4.46 0.000098 13.98 

All Infants:

 0.000021 29.69 0.000084 119.98 0.000292 417.22 

Children 1-2:

 0.000016 22.99 0.000051 72.83 0.000148 210.85 

Children 3-5:

 0.000015 21.47 0.000044 62.23 0.000127 181.19 

Children 6-12:

 0.000011 15.77 0.000034 49.05 0.000092 131.52 

Youth 13-19:

 0.000008 11.19 0.000025 35.37 0.000077 109.91 

Adults 20-49:

 0.000009 13.22 0.000030 43.03 0.000094 134.09 

Adults 50-99:

 0.000009 1.24 0.000028 4.06 0.000087 12.49 

Female 13-49:

 0.000009 13.00 0.000030 42.16 0.000094 134.97 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute NCcotton-maxrate.R08 Adjustment factor #2 NOT used.

Analysis Date: 08-17-2015/15:30:58 Residue file dated: 08-17-2015/15:08:49

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000035 5.04 0.000101 14.44 0.000274 39.14 

All Infants:

 0.000092 131.21 0.000304 433.64 0.000797 1138.63 

Children 1-2:

 0.000052 74.87 0.000151 215.93 0.000415 593.33 

Children 3-5:

 0.000046 65.68 0.000127 181.38 0.000334 476.47 

Children 6-12:
Page 21 of 28

 0.000033 47.76 0.000093 132.79 0.000251 358.82 

Youth 13-19:

 0.000026 37.66 0.000078 111.64 0.000219 312.84 

Adults 20-49:

 0.000035 50.44 0.000100 142.84 0.000259 369.42 

Adults 50-99:

 0.000035 4.96 0.000094 13.48 0.000239 34.08 

Female 13-49:

 0.000035 50.12 0.000101 143.58 0.000261 372.72 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute NCcotton-typrate.R08 Adjustment factor #2 NOT used.

Analysis Date: 08-17-2015/15:35:00 Residue file dated: 08-17-2015/15:09:08

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000008 1.09 0.000023 3.28 0.000068 9.78 

All Infants:

 0.000013 19.25 0.000061 86.87 0.000193 275.45 

Children 1-2:

 0.000013 18.45 0.000038 54.91 0.000103 146.46 

Children 3-5:

 0.000012 17.67 0.000032 45.69 0.000088 125.34 

Children 6-12:

 0.000009 12.98 0.000026 36.62 0.000065 93.02 

Youth 13-19:

 0.000006 9.17 0.000019 27.80 0.000055 78.40 

Adults 20-49:

 0.000007 9.86 0.000022 31.35 0.000064 91.15 

Adults 50-99:

 0.000006 0.92 0.000020 2.92 0.000059 8.45 

Female 13-49:

 0.000007 9.69 0.000022 31.08 0.000064 91.98 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute MScotton-maxrate-BEADstartdate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-17-2015/15:16:39 Residue file dated: 08-17-2015/15:07:51

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000020 2.85 0.000067 9.54 0.000299 42.71 

All Infants:

 0.000049 69.61 0.000182 259.82 0.000868 1239.35 
Page 22 of 28

Children 1-2:

 0.000030 43.30 0.000100 142.33 0.000444 633.97 

Children 3-5:

 0.000027 38.13 0.000084 119.93 0.000365 520.83 

Children 6-12:

 0.000019 27.82 0.000061 87.74 0.000269 384.78 

Youth 13-19:

 0.000015 21.65 0.000051 72.74 0.000229 327.44 

Adults 20-49:

 0.000020 28.26 0.000065 93.40 0.000296 422.89 

Adults 50-99:

 0.000019 2.75 0.000063 8.98 0.000279 39.80 

Female 13-49:

 0.000020 28.01 0.000065 93.54 0.000297 424.06 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute MScotton-typrate-BEADdate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-17-2015/15:26:53 Residue file dated: 08-17-2015/15:08:30

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000011 1.53 0.000032 4.62 0.000100 14.30 

All Infants:

 0.000024 34.62 0.000086 123.41 0.000305 435.12 

Children 1-2:

 0.000017 24.90 0.000052 73.98 0.000151 215.09 

Children 3-5:

 0.000016 23.19 0.000045 63.85 0.000131 186.69 

Children 6-12:

 0.000012 16.95 0.000035 49.51 0.000092 131.97 

Youth 13-19:

 0.000009 12.24 0.000026 36.84 0.000079 113.54 

Adults 20-49:

 0.000010 14.68 0.000031 44.62 0.000097 138.00 

Adults 50-99:

 0.000010 1.39 0.000029 4.18 0.000090 12.84 

Female 13-49:

 0.000010 14.47 0.000031 43.82 0.000098 139.43 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute MScotton-typrate-14DI.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-17-2015/15:22:57 Residue file dated: 08-17-2015/15:08:11

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 
Page 23 of 28

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000010 1.39 0.000032 4.62 0.000126 17.97 

All Infants:

 0.000020 29.19 0.000083 119.00 0.000382 545.27 

Children 1-2:

 0.000016 22.72 0.000052 74.31 0.000187 267.74 

Children 3-5:

 0.000015 21.35 0.000046 65.09 0.000156 222.23 

Children 6-12:

 0.000011 15.63 0.000035 49.85 0.000114 163.18 

Youth 13-19:

 0.000008 11.08 0.000026 36.78 0.000098 140.16 

Adults 20-49:

 0.000009 13.21 0.000031 44.57 0.000124 176.68 

Adults 50-99:

 0.000009 1.25 0.000029 4.19 0.000116 16.51 

Female 13-49:

 0.000009 12.98 0.000031 43.57 0.000125 178.01 

Acute Food Only

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Acute Food Only.R08 Adjustment factor #2 NOT used.

Analysis Date: 08-17-2015/15:12:20 Residue file dated: 08-17-2015/15:07:33

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000004 5.02 0.000007 10.09 0.000021 30.11 

All Infants:

 0.000002 2.59 0.000005 7.07 0.000012 16.52 

Children 1-2:

 0.000008 11.25 0.000014 19.88 0.000063 89.55 

Children 3-5:

 0.000008 10.81 0.000015 21.64 0.000066 94.46 

Children 6-12:

 0.000006 8.24 0.000012 17.10 0.000042 60.63 

Youth 13-19:

 0.000004 5.06 0.000007 9.41 0.000027 38.99 

Adults 20-49:

 0.000002 3.43 0.000005 6.67 0.000019 27.08 

Adults 50-99:

 0.000002 0.27 0.000003 0.47 0.000008 1.16 

Female 13-49:

 0.000002 3.49 0.000005 6.79 0.000013 18.02 

 
Page 24 of 28

Attachment 3: Steady State (Food + Drinking Water) Results

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State TXcotton-maxrate-BEADstartdate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:59:06 Residue file dated: 08-17-2015/15:14:22

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000022 3.19 0.000069 9.90 0.000231 33.06 

All Infants:

 0.000057 189.85 0.000195 649.66 0.000721 2404.99 

Children 1-2:

 0.000034 114.82 0.000102 339.04 0.000342 1141.43 

Children 3-5:

 0.000030 101.34 0.000086 287.68 0.000278 927.36 

Children 6-12:

 0.000022 72.54 0.000063 209.02 0.000207 689.00 

Youth 13-19:

 0.000017 57.27 0.000052 174.84 0.000180 598.36 

Adults 20-49:

 0.000022 73.43 0.000068 227.46 0.000226 753.48 

Adults 50-99:

 0.000021 7.14 0.000066 21.89 0.000213 70.96 

Female 13-49:

 0.000022 73.19 0.000069 228.43 0.000231 769.35 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State TXcotton-typrate-BEADdate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/07:07:43 Residue file dated: 08-17-2015/15:15:01

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000011 1.50 0.000030 4.25 0.000086 12.24 

All Infants:

 0.000023 78.02 0.000083 276.89 0.000259 864.50 

Children 1-2:

 0.000017 55.99 0.000045 150.13 0.000128 427.98 

Children 3-5:

 0.000015 50.80 0.000039 128.94 0.000104 347.11 

Children 6-12:

 0.000011 37.81 0.000029 95.54 0.000078 259.26 

Youth 13-19:

 0.000008 28.02 0.000023 76.87 0.000067 222.38 
Page 25 of 28

Adults 20-49:

 0.000010 33.34 0.000029 96.10 0.000082 273.74 

Adults 50-99:

 0.000009 3.15 0.000028 9.17 0.000078 25.87 

Female 13-49:

 0.000010 32.71 0.000029 96.71 0.000084 278.47 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State TXcotton-typrate-14DI.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/07:04:53 Residue file dated: 08-17-2015/15:14:42

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000010 1.43 0.000028 4.01 0.000076 10.89 

All Infants:

 0.000022 73.50 0.000078 261.51 0.000227 755.19 

Children 1-2:

 0.000016 53.39 0.000044 146.89 0.000114 379.65 

Children 3-5:

 0.000015 48.50 0.000037 124.30 0.000092 306.68 

Children 6-12:

 0.000011 36.17 0.000027 90.79 0.000069 231.24 

Youth 13-19:

 0.000008 27.05 0.000022 72.74 0.000059 196.63 

Adults 20-49:

 0.000010 31.97 0.000027 90.67 0.000073 242.66 

Adults 50-99:

 0.000009 2.98 0.000026 8.67 0.000068 22.76 

Female 13-49:

 0.000009 31.24 0.000027 91.35 0.000074 246.95 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State NCcotton-maxrate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:53:37 Residue file dated: 08-17-2015/15:13:44

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000036 5.18 0.000091 13.02 0.000216 30.91 

All Infants:
Page 26 of 28

 0.000097 322.70 0.000277 922.50 0.000630 2099.62 

Children 1-2:

 0.000053 176.95 0.000137 456.31 0.000324 1081.65 

Children 3-5:

 0.000046 154.31 0.000112 373.10 0.000252 841.48 

Children 6-12:

 0.000033 110.59 0.000083 275.07 0.000193 642.26 

Youth 13-19:

 0.000027 89.73 0.000071 235.45 0.000168 559.52 

Adults 20-49:

 0.000036 121.38 0.000090 300.71 0.000202 673.79 

Adults 50-99:

 0.000036 11.90 0.000085 28.35 0.000186 61.96 

Female 13-49:

 0.000036 121.00 0.000091 304.66 0.000204 681.09 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State NCcotton-typrate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:56:38 Residue file dated: 08-17-2015/15:14:04

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000008 1.11 0.000020 2.91 0.000053 7.55 

All Infants:

 0.000015 49.75 0.000056 185.99 0.000152 508.00 

Children 1-2:

 0.000013 42.91 0.000035 116.79 0.000079 264.91 

Children 3-5:

 0.000012 39.98 0.000031 102.72 0.000071 235.69 

Children 6-12:

 0.000009 30.06 0.000022 73.44 0.000048 161.32 

Youth 13-19:

 0.000006 21.11 0.000017 55.18 0.000041 135.01 

Adults 20-49:

 0.000007 24.01 0.000020 65.12 0.000050 166.18 

Adults 50-99:

 0.000007 2.22 0.000018 6.10 0.000047 15.54 

Female 13-49:

 0.000007 23.10 0.000020 65.85 0.000050 167.41

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State MScotton-maxrate-BEADstartdate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:40:29 Residue file dated: 08-17-2015/15:12:03

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:
Page 27 of 28

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000021 2.95 0.000064 9.09 0.000253 36.20 

All Infants:

 0.000053 175.40 0.000172 573.10 0.000771 2570.91 

Children 1-2:

 0.000032 105.83 0.000093 309.93 0.000388 1291.67 

Children 3-5:

 0.000028 93.89 0.000078 260.31 0.000304 1012.26 

Children 6-12:

 0.000020 67.70 0.000058 192.09 0.000224 746.10 

Youth 13-19:

 0.000016 52.60 0.000048 160.46 0.000194 646.11 

Adults 20-49:

 0.000021 68.44 0.000062 207.35 0.000252 840.83 

Adults 50-99:

 0.000020 6.64 0.000060 20.13 0.000236 78.75 

Female 13-49:

 0.000020 68.16 0.000062 207.55 0.000257 855.74

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State MScotton-typrate-BEADdate.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:50:44 Residue file dated: 08-17-2015/15:12:43

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000011 1.55 0.000029 4.21 0.000076 10.88 

All Infants:

 0.000025 83.41 0.000082 272.15 0.000231 768.55 

Children 1-2:

 0.000017 57.61 0.000044 147.89 0.000117 388.38 

Children 3-5:

 0.000016 51.82 0.000038 126.42 0.000093 309.20 

Children 6-12:

 0.000012 38.76 0.000028 94.29 0.000069 229.82 

Youth 13-19:

 0.000009 28.80 0.000023 75.70 0.000060 199.66 

Adults 20-49:

 0.000010 34.59 0.000028 94.89 0.000073 243.06 

Adults 50-99:

 0.000010 3.27 0.000027 9.10 0.000068 22.51 

Female 13-49:

 0.000010 34.15 0.000029 95.19 0.000074 246.38 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State MScotton-typrate-14DI.R08

Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:43:40 Residue file dated: 08-17-2015/15:12:25
Page 28 of 28

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000010 1.42 0.000030 4.33 0.000102 14.52 

All Infants:

 0.000022 72.43 0.000081 271.05 0.000307 1023.44 

Children 1-2:

 0.000016 53.32 0.000046 152.45 0.000151 503.65 

Children 3-5:

 0.000015 48.37 0.000039 129.13 0.000123 410.00 

Children 6-12:

 0.000011 36.22 0.000029 96.97 0.000091 302.80 

Youth 13-19:

 0.000008 26.88 0.000023 77.67 0.000079 262.81 

Adults 20-49:

 0.000010 32.09 0.000029 97.74 0.000100 332.76 

Adults 50-99:

 0.000009 2.99 0.000028 9.44 0.000094 31.23 

Female 13-49:

 0.000009 31.31 0.000029 97.81 0.000102 339.80 

Steady State Food Only

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for DICROTOPHOS NHANES 2003-2008 2-Day

Residue file: 035201 Steady State Food Only.R08 Adjustment factor #2 NOT used.

Analysis Date: 08-18-2015/06:37:03 Residue file dated: 08-17-2015/15:10:19

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two-Day Average Results Reported

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000003 0.47 0.000006 0.91 0.000018 2.63 

All Infants:

 0.000002 5.87 0.000005 15.30 0.000008 26.51 

Children 1-2:

 0.000007 22.28 0.000012 40.67 0.000044 145.94 

Children 3-5:

 0.000007 23.33 0.000012 39.21 0.000037 123.80 

Children 6-12:

 0.000005 16.55 0.000010 32.51 0.000023 78.25 

Youth 13-19:

 0.000003 10.87 0.000006 18.81 0.000017 57.57 

Adults 20-49:

 0.000002 7.32 0.000004 13.65 0.000011 37.11 

Adults 50-99:

 0.000002 0.57 0.000003 1.01 0.000006 1.96 

Female 13-49:

 0.000002 7.48 0.000004 13.12 0.000011 35.66