UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-K/A
(Amendment No. 1)



x
ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2017



Commission file number: 000-28508



AVADEL
PHARMACEUTICALS PLC

(Exact name of registrant as specified
in its charter)



|Ireland                                                                                          |  | 98-1341933                          
|------------------------------------------------------------------------------------------------ |  | ------------------------------------
|State or other jurisdiction of incorporation or organization                                     |  | (I.R.S. Employer Identification No.)
|                                                                                                 |  |                                     
|Block 10-1, Blanchardstown Corporate
        Park
        Ballycoolin
        Dublin 15, Ireland |  | Not Applicable                      
|(Address of principal executive offices)                                                         |  | (Zip Code)                          



Registrant’s telephone number,
including area code: +011-1-485-1200



Securities registered pursuant to Section 12(b)
of the Act:



|American Depositary Shares*
        Ordinary Shares** |  | NASDAQ Stock Market LLC
        (NASDAQ Global Market)
|----------------------------------------------------- |  | ------------------------------------------------------
|Title of each class                                   |  | Name of exchange on which registered                  



| | * | American Depositary Shares
may be evidenced by American Depository Receipts. Each American Depositary Share represents one (1) Ordinary Share.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------



| | ** | Nominal value $0.01 per share.
Not for trading, but only in connection with the listing of American Depositary Shares.
| | -- | ----------------------------------------------------------------------------------------------------------------------



Securities registered pursuant to Section 12(g)
of the Act: None



Indicate
by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ̈ Nox



Indicate
by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.  
Yes ̈ Nox



Indicate
by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports),
and (2) has been subject to such filing requirements for the past 90 days. Yesx
No ̈



Indicate
by check mark whether the registrant has submitted electronically and posted on its corporate Website, if any, every Interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the
preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yesx No ̈



Indicate by check mark if disclosure
of delinquent filers pursuant to Item 405 of Regulation S-K (§229.405 of this chapter) is not contained herein, and will
not be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference
in Part III of this Form 10-K or any amendment to this Form 10-K. ̈



Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions
of “large accelerated filer”, “accelerated filer”, “smaller reporting company”, and “emerging
growth company” in Rule 12b-2 of the Exchange Act.



|Large accelerated filer ̈ | Accelerated filerx        
|------------------------ | --------------------------
|Non-accelerated filer ̈   | Smaller reporting company ̈
|                         | Emerging growth company ̈  



If an emerging growth company,
indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised
financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ̈



Indicate by check mark whether
the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ̈
Nox



The aggregate market value of voting stock held by non-affiliates
of the registrant as of the last business day of the registrant’s most recently completed second fiscal quarter was $434,848,871
based on the closing sale price of the registrant’s American Depositary Shares as reported by the Nasdaq Global Market on
June 30, 2017. Such market value excludes 659,963 ordinary shares, $0.01 per share nominal value, held by each officer and director
and by shareholders that the registrant concluded were affiliates of the registrant on that date. Exclusion of such shares should
not be construed to indicate that any such person possesses the power, direct or indirect, to direct or cause the direction of
the management or policies of the registrant or that such person is controlled by or under common control with the registrant.



The number of the registrant’s ordinary shares, $0.01
per share nominal value, outstanding as of April 27, 2018 was 36,745,376.



DOCUMENTS INCORPORATED BY REFERENCE



None.


















TABLE OF CONTENTS



|                                                           | Page #                                                                                        
|---------------------------------------------------------- | ----------------------------------------------------------------------------------------------
|                                                           |                                                                                               
|Explanatory Note                                           | 3                                                                                             
|Cautionary Disclosure Regarding Forward-Looking Statements | 3                                                                                             
|                                                           |                                                                                               
|PART III                                                   |                                                                                               
|Item 10.                                                   | Directors, Executive Officers and Corporate Governance                                        
|Item 11.                                                   | Executive Compensation                                                                        
|Item 12.                                                   | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
|Item 13.                                                   | Certain Relationships and Related Transactions, and Director Independence                     
|Item 14.                                                   | Principal Accounting Fees and Services                                                        
|                                                           |                                                                                               
|PART IV                                                    |                                                                                               
|Item 15.                                                   | Exhibits                                                                                      
|                                                           |                                                                                               
|SIGNATURES                                                 | 42                                                                                            



-2-







Explanatory Note





This Amendment No. 1 (this “Amendment”) amends Avadel
Pharmaceuticals plc’s (“Avadel,” the “Company,” “we,” “our,” or “us”)
Annual Report on Form 10-K for the fiscal year ended December 31, 2018 (the “Original Form 10-K”) as filed with the
Securities and Exchange Commission (the “SEC”) on March 16, 2018. We are filing this Amendment solely for the following
two purposes:



| | · | To include the information required by Items 10, 11,
12, 13 and 14 of Part III of Form 10-K, which we expected to be incorporated by reference from our definitive proxy statement
for the 2018 Annual General Meeting of Shareholders. As we no longer anticipate filing our definitive proxy statement within 120
days of the fiscal year ended December 31, 2017, Part III of the Original Form 10-K is hereby amended.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | To re-file, with slightly modified redactions, the
License and Development Agreement by and between Cerecor, Inc. and Flamel Ireland Limited operating under the trade name of Avadel
Ireland dated as of February 16, 2018, that was filed as Exhibit 10.44 to the Original Form 10-K (the “Exhibit”).
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



In addition, as required by Rule 12b-15 under the Securities
Exchange Act of 1934, new certifications by the Company’s principal executive officer and principal financial officer are
filed as exhibits to this Form 10-K/A. Except as expressly noted in this Amendment, this Amendment does not reflect events occurring
after the Original Form 10-K or modify or update in any way any of the other disclosures contained in the Original Form 10-K.
Accordingly, this Amendment should be read in conjunction with the Original Form 10-K and our other SEC filings.



Cautionary Disclosure Regarding Forward-Looking
Statements



This Amendment contains
forward-looking statements. We may make additional written or oral forward-looking statements from time to time in filings with
the Securities and Exchange Commission or otherwise. The words “will,” “may,” “believe,” “expect,”
“anticipate,” “estimate,” “project” and similar expressions, and the negatives thereof, identify
forward-looking statements, which speak only as of the date the statement is made. Such forward-looking statements are within the
meaning of that term in Section 27A of the Securities Act of 1933 (the “Securities Act”) and Section 21E of the Securities
Exchange Act of 1934 (the “Exchange Act”). Although we believe that our forward-looking statements are based on reasonable
assumptions within the bounds of our knowledge of our business and operations, our business is subject to significant risks and
there can be no assurance that actual results of our research, development and commercialization activities and our results of
operations will not differ materially from our expectations. Factors that could cause actual results to differ from expectations
in our forward-looking statements include, among others, those specified in “Risk Factors” in Part I, Item 1A of the
Original Form 10-K, including:



| | • | Risks relating to our license agreement with Serenity Pharmaceuticals,
LLC (“Serenity”) including:
| | - | --------------------------------------------------------------------------------------------------

| | ◦ | consumer purchases of Noctiva are subject to risks related
to reimbursement from government agencies and other third parties;
| | - | -----------------------------------------------------------------------------------------------------------------------------

| | ◦ | our internal analyses may overstate the market opportunity
in the United States for the drug desmopressin acetate (the “Drug”) or we may not effectively exploit such market
opportunity;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | ◦ | significant safety or drug interaction problems could arise
with respect to the Drug;
| | - | -------------------------------------------------------------------------------------

| | ◦ | we may not successfully increase awareness of nocturia and the potential benefits of the Drug;
| | - | ----------------------------------------------------------------------------------------------

| | ◦ | patents and proprietary rights associated with the Drug may not provide adequate protection;
| | - | --------------------------------------------------------------------------------------------

| | ◦ | patents licensed to us under our license agreement with Serenity that cover the Drug are subject
to litigation and if Serenity is unsuccessful in defending this litigation, we may lose its exclusive rights to such patents; and
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | ◦ | the need for our management to focus attention on the development and commercialization of the
Drug could cause our ongoing business operations to suffer.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------

| | • | we depend on a small number of products and customers for
the majority of our revenues and the loss of any one of these products or customers could reduce our revenues significantly.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | • | we may depend on partnership arrangements or strategic
alliances for the commercialization of some of our products, and the failure of any third party to fulfill its duties under such
an arrangement or alliance could have a material adverse effect on our financial condition and results of operation.
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | • | our products may not reach the commercial market for a
number of reasons, which would adversely affect our future revenues.
| | - | ---------------------------------------------------------------------------------------------------------------------------

| | • | we must invest substantial sums in research and development
(“R&D”) in order to remain competitive, and we may not fully recover these investments.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------

| | • | we depend upon a limited number of third parties to manufacture
our products and to deliver certain raw materials used in our products and the failure of any such third party to efficiently
manufacture such products or to timely deliver sufficient quantities of raw materials, as applicable, could have a material adverse
effect on our business.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | • | if our competitors develop and market technologies or products
that are more effective or safer than ours, or obtain regulatory approval for and market such technologies or products before
we do, our commercial opportunity will be diminished or eliminated.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | • | if we cannot keep pace with the rapid technological change
in our industry, we may lose business, and our products could become obsolete or noncompetitive.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------

| | • | if we cannot adequately protect our intellectual property
and proprietary information, we may be unable to sustain a competitive advantage.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------

| | • | our effective tax rate could be highly volatile and could
adversely affect our operating results.
| | - | -------------------------------------------------------------------------------------------------

| | • | we depend on key personnel to execute our business plan
and the loss of any one or more of these key personnel may limit our ability to effectively pursue our business plan.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Forward-looking statements are subject
to inherent risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ
materially from those set forth in, contemplated by or underlying the forward-looking statements. We undertake no obligation to
update these forward-looking statements as a result of new information, future events or otherwise. You should not place undue
reliance on these forward-looking statements.



-3-







PART III



| | Item 10. | Directors, Executive Officers and Corporate Governance.
| | -------- | -------------------------------------------------------



Directors



Background



The following table
provides summary information about each of our directors.



|Nominee             |  | DirectorSince |  | Principal Occupation or Experience                                                |  | Committees  
|------------------- |  | ------------- |  | --------------------------------------------------------------------------------- |  | ------------
|                    |  |               |  |                                                                                   |  |             
|Michael S. Anderson |  | 2012          |  | Chief Executive Officer of Avadel Pharmaceuticals plc                             |  | -           
|                    |  |               |  |                                                                                   |  |             
|Francis J.T. Fildes |  | 2008          |  | Former senior executive in the pharmaceutical industry                            |  | (1*)(2)     
|                    |  |               |  |                                                                                   |  |             
|Christophe Navarre  |  | 2014          |  | Chief Executive Officer of Moët Hennessy                                          |  | (1)(3)      
|                    |  |               |  |                                                                                   |  |             
|Craig R. Stapleton  |  | 2011          |  | Former U.S. Ambassador to France, Senior Advisor to Stone Point Capital           |  | (1)(2)(3)(4)
|                    |  |               |  |                                                                                   |  |             
|Peter Thornton      |  | 2017          |  | Chief Financial Officer, Director at Technopath Clinical Diagnostics              |  | (2*)(3)     
|                    |  |               |  |                                                                                   |  |             
|Benoit Van Assche   |  | 2014          |  | Former senior executive in the chemical, pharmaceutical and healthcare industries |  | (1)(2)(3*)  



* Chairman
of Committee

(1) Member
of the Compensation Committee

(2) Member
of the Audit Committee

(3) Member
of the Nominating and Corporate Governance Committee

(4) Appointed
as a Non-Executive Chairman of the Board of Directors in 2014



Set forth below is
information for each director concerning the individual’s age, principal occupation, employment and directorships during
the past five years, positions with the Company, the year in which he first became a director of the Company and his term of office
as a director. Also set forth below is a brief discussion of the specific experience, qualifications, attributes or skills that
led to the Board’s conclusion that, in light of our business and structure, each director should serve as a director as of
the date of this Form 10-K/A.



Michael S. Anderson, age 69, has
been a member of the Board since June 2012. Mr. Anderson has been Chief Executive Officer of Avadel since March 2012. Prior to
joining Avadel, Mr. Anderson was Chief Executive Officer of Éclat Pharmaceuticals LLC since its creation in November 2010
until it was acquired by Avadel in March 2012. Before his employment at Éclat, Mr. Anderson was President and CEO of the
generic business division of KV Pharmaceutical Company, a company engaged in the development of proprietary drug delivery systems
and formulation technologies, an executive at ETHEX Corporation, a pharmaceutical company which engaged in developing and marketing
of multisource drugs, and President and CEO of Ther-Rx Corporation, a leader in women’s healthcare. Mr. Anderson also has
worked for Schein Pharmaceuticals, a generic pharmaceuticals company, and started his career at A.H Robins, a pharmaceuticals company.
Based on his experience as a seasoned and disciplined executive in the pharmaceutical industry, Mr. Anderson brings to the Board
over 47 years of experience.



Dr. Francis J.T. Fildes, age 73,
has been a member of Avadel’s Board since February 2008. Dr. Fildes was Managing Director of Fildes Partners Ltd, a management
consultancy business to the bio-pharmaceutical and healthcare industries, which he founded in September 2002 and held until November
2014. Prior to this, Dr. Fildes held the position of Senior Vice President: Head of Global Drug Development for AstraZeneca a global
pharmaceutical company, from April 1999 until December 2002. Since leaving AstraZeneca, Dr. Fildes has also been a Director of
ProStrakan Pharmaceuticals plc and Keryx Inc, both public biopharmaceutical companies and Strakan Ltd, Proskelia SA and Pyramed
Pharma, three privately funded bio-pharmaceutical Companies. Dr. Fildes is a Fellow of the Royal Society of Medicine and a Fellow
of the Royal Society of Chemistry. Based on his experience as an executive, a director and consultant in the pharmaceutical industry,
Dr. Fildes brings to the Board and the Compensation and Audit Committees over 40 years of experience.



Mr. Christophe Navarre, age 59,
has been a member of Avadel’s Board since June 2014. Since May 1997, Mr. Navarre has been Chief Executive Officer of Moët
Hennessy, the Wines and Spirits division of LVMH Moët Hennessy Louis Vuitton SA, a worldwide luxury brands company. Mr. Navarre
is also a board member of the Comité Colbert, a luxury brand trade association, a member of the Heineken Advisory Board,
and President of the Fédération des Exportateurs de Vins et Spiritueux de France, the French wine export association.
He is an Officer of the French Legion of Honor, a Commandeur de l’Ordre du Mérite Agricole and an Officier de l’Ordre
de la Couronne in Belgium. Based on his experiences as a successful business leader and board member of public and private companies,
Mr. Navarre brings to the Board and the Compensation and Nominating and Corporate Governance Committees over 34 years of experience.



-4-







The Honorable Craig R. Stapleton,
age 73, has been a member of the Board of Directors since June 2011, and became Chairman of the Board in July 2014. He currently
serves as a Senior Advisor to Stone Point Capital. He served as President of Marsh and McLennan Real Estate Advisors of New York
from 1982 until 2001. From 1989 to 1998 Stapleton co-owned the Texas Rangers baseball team with George W. Bush. In July 2009, he
became a co-owner of the St. Louis Cardinals. He has served on the Board of Directors for companies including Allegheny Properties,
IDS Realty Inc., Investors Savings and Loan, Metro PCS, and TB Woods, Abercrombie and Fitch, and Carlile Bank. Mr. Stapleton served
as the United States Ambassador to France from 2005-2009 and as Ambassador to the Czech Republic from 2001 to 2004. He has also
served on the Board of the Peace Corps. He is the Chairman of the Vaclav Havel Foundation, Chairman of the American Friends of
Compiegne, and a Trustee of the George W. Bush Library Foundation. He has served on the Visiting Committee for Harvard College
Athletics and the Committee on University Resources and Athletics. Ambassador Stapleton brings over 40 years of broad perspective
and experience.



Mr. Peter Thornton, age 53, is the
Chief Financial Officer of Technopath Clinical Diagnostics, an Irish company that provides quality control materials and software
solutions to clinical laboratories, a position he has held since January 2014.  Prior to joining Technopath Clinical Diagnostics,
from September 2011 to December 2013 Mr. Thornton was Senior Vice President - Business Integration for Alkermes plc, a global biopharmaceuticals
company headquartered in Dublin, Ireland; from July 2007 to September 2011 he was Senior Vice President - Corporate and Business
Development for Elan Drug Technologies, an Elan Corporation plc division engaged in developing and manufacturing drug delivery
technology based pharmaceutical products; from September 2006 to July 2007 he was President and Chief Operating Officer of Circ
Pharma Limited, a specialty pharmaceutical company; and from June 2004 to September 2006 he was Chief Financial Officer of Agenus
Inc., a NASDAQ-listed biotechnology company.  Mr. Thornton has previously served as a non-executive director of both public
and private companies and currently holds two non-executive directorships in private companies.   Mr. Thornton worked for
the international public accounting firm of KPMG for seven years in Ireland and France and is a fellow of Chartered Accountants
Ireland. He holds a Bachelor of Commerce degree from University College Cork, Ireland.  Based on his experience in the pharmaceutical
industry and as a chief financial officer, Mr. Thornton brings to the Board, Audit Committee and the Nominating and Corporate Governance
Committee over 25 years of experience.



Mr. Benoit (Ben) Van Assche, age
72, has been a member of the Board since June 2014. Mr. Van Assche is a member of the international jury that assists the government
of the Walloon Region in its policy towards clusters of competitiveness, in particular the BioWin health cluster, a position he
has held since December 2006. From 1985 to 2005 he served as member of the Executive Committee of UCB Pharma, with responsibility
for the worldwide pharmaceutical and chemical business. Prior to this he worked in international roles for Alcon and Baxter. He
has been Director and Chairman of Bone Therapeutics, a biotech company specialized in cell therapy for bone diseases, from April
2008 until June 2013 and Executive Chairman and Director of Armonea, a chain of nursing homes and senior service residences from
May 2008 until December 2012. From 2004 to 2006 Mr. Van Assche served as a board member and Chairman of Essenscia, the federation
of chemical activities and life sciences in Belgium. Based on his experience as a director and senior executive in the chemical,
pharmaceutical and healthcare industries, Mr. Van Assche brings to the Board and the Compensation, Audit, and Nominating and Corporate
Governance Committees over 40 years of experience.



Board Independence



All of our directors,
with the exception of Mr. Anderson, have been determined to be independent under the rules of the Nasdaq Global Market. As our
Chief Executive Officer, Mr. Anderson is not independent.



Audit Committee



The Board has an Audit
Committee composed of Mr. Thornton (Chairman), Francis J.T. Fildes, Benoit Van Assche, and Ambassador Craig Stapleton. The Board
has determined that all of the members of the Audit Committee are independent within the meaning of applicable SEC regulations
and the listing standards of Nasdaq and that Mr. Thornton, as the chair of the Committee, is qualified as an audit committee financial
expert within the meaning of SEC regulations. The Board has also determined that Mr. Thornton has accounting and related financial
management expertise within the meaning of the listing standards of Nasdaq and that each member is financially literate within
the meaning of such listing standards. The Board has also determined that Mr. Thornton (i) is independent within the meaning of
applicable SEC regulations and the listing standards of Nasdaq, (ii) is qualified as an audit committee financial expert within
the meaning of SEC regulations, and (iii) has accounting and related financial management expertise within the meaning of the listing
standards of Nasdaq and that he is financially literate within the meaning of such listing standards.



-5-







Code of Business Conduct and Ethics,
and Financial Integrity Policy



We have adopted a written
Code of Business Conduct and Ethics (the “Code”) that applies to all of our employees, as well as a Financial Integrity
Policy (the “Financial Integrity Policy”) that applies to our Chief Executive Officer, Chief Financial Officer, Chief
Accounting Officer, Senior Tax Director and Controller (or persons performing similar functions). These documents cover a broad
range of professional conduct, including employment policies, conflicts of interest, intellectual property and the protection of
confidential information, as well as adherence to all laws and regulations applicable to the conduct of our business. A copy of
the Code and the Financial Integrity Policy is available on the Corporate Governance section of our website, which is located at
www.Avadel.com,under “About-Corporate Responsibility”. If we make any substantive amendments to, or grant any
waivers from, the Code or Financial Integrity Policy for any officer or director, we intend to satisfy the disclosure requirement
under Item 5.05 of Form 8-K by disclosing the nature of such amendment or waiver on our website or in a current report on Form 8-K.



Executive Officers



Identification of Executive Officers



Our executive officers
serve at the discretion of the Board, and serve until they resign, are removed or are otherwise disqualified to serve, or until
their successors are elected and qualified. Our executive officers presently include:



Michael S. Anderson – Chief Executive
Officer. For information regarding Mr. Anderson, see “Nominees for Election as Directors” above.



Gregory J. Divis – Executive Vice
President and Chief Operating Officer. Gregory J. Divis, age 51, was appointed Executive Vice President and Chief Commercial
Officer in January 2017, and was promoted to Chief Operating Officer in March 2018. Mr. Divis brings to this role more than 25
years of experience in the pharmaceutical industry, and is responsible for managing commercial strategy and execution across all
of the Company's portfolio products. Prior to joining Avadel, Mr. Divis served as an Operating Partner for Linden Capital, a middle-market
healthcare-focused private equity firm from June 2015 to December 2016. Prior to Linden Capital, from June 2010 to November 2014
Mr. Divis was the President and Chief Executive Officer of K-V Pharmaceutical Company ("K-V"), a company engaged in the
development of proprietary drug delivery systems and formulation technologies. On August 4, 2012, K-V and certain of its subsidiaries
filed voluntary petitions for reorganization under Chapter 11 of the United States Bankruptcy Code and, on September 16, 2013,
successfully emerged pursuant to a plan of reorganization. Following bankruptcy, K-V changed its name to Lumara Health, Inc., strengthened
its business and engaged in a series of transactions culminating in its acquisition by AMAG Pharmaceuticals in November 2014. Mr.
Divis has also held such notable roles as President, Ther-Rx Corporation, Vice-President, Business Development & Lifecycle
Management at Sanofi-Aventis and Vice-President and General Manager, UK and Ireland, for Schering-Plough Corporation. Mr. Divis
is a graduate of the University of Iowa.



Sandra L. Hatten – Senior Vice
President of Quality and Regulatory Affairs.Sandra L. Hatten, age 61, was appointed Senior Vice President of Quality and Regulatory
Affairs of Avadel in June 2015. Prior to joining Avadel, Ms. Hatten was employed from October 2010 to June 2015 by Mallinckrodt,
plc, a global specialty biopharmaceutical company, where she served as Senior Vice President of Quality and Regulatory Compliance
from February 2014 until June 2015. From October 2010 until September 2012, Ms. Hatten was employed by Mallinckrodt, as Director
and Sr. Director of Quality. From September 2012 until February 2014, Ms. Hatten held the position of Vice President, Quality and
Regulatory Compliance with Mallinckrodt. Ms. Hatten has more than 30 years of experience in the pharmaceutical industry, during
which she has held leadership roles in quality and operations for branded as well as generic drug manufacturers, where she has
been responsible for establishing and implementing broad-based quality programs across multiple sites. Ms. Hatten holds bachelor’s
and master’s degrees from Marshall University in Huntington, West Virginia.



Phillandas T. Thompson – Senior
Vice President, General Counsel and Corporate Secretary. Phillandas T. (Phil) Thompson, age 44, has been Senior Vice President
and General Counsel of Avadel since November 2013. Before joining Avadel, Mr. Thompson was employed from January 2012 until November
2013 at West-Ward Pharmaceutical Corp. as Vice President, Legal Affairs, from January 2010 until November 2011 at Paddock Laboratories,
Inc. as Vice President, General Counsel, from April 2006 until January 2010 at KV Pharmaceutical Co as Vice President, Strategic
Business Transactions and Assistant General Counsel, and from October 2002 until March 2006 at Barr Laboratories, Inc. as Associate
General Counsel. Prior to his employment with Barr Laboratories, Mr. Thompson was a corporate associate at White & Case, LLP.
Mr. Thompson is a member of the New York Bar, the Missouri Bar, and the Minnesota Bar and has several other professional affiliations.
Mr. Thompson earned a B.A. from Washington University in St. Louis and is also a graduate of the University of Michigan Law School
(Juris Doctor) and the University of Michigan Business School (Master of Business Administration).



-6-







Michael F. Kanan – Senior Vice
President and Chief Financial Officer. Michael F. Kanan, age 55, was appointed Senior Vice President and Chief Financial Officer
of Avadel in November 2015. Prior to joining Avadel, Mr. Kanan was employed by Sigma-Aldrich Corp. from April 2009 until November
2015, where he served as Vice President Finance, Corporate Controller and Chief Accounting Officer from April 2009 until November
2015. Sigma-Aldrich was a life science and high technology company which was acquired by Merck KGaA, a health care, life science
and performance materials company based in Germany, in November 2015. Mr. Kanan began his career at the international accounting
firm Deloitte & Touche, and also held accounting and finance leadership positions with Hutchinson Group, a subsidiary of Total
S.A., and Meritor, a global supplier of drivetrain, mobility, braking and aftermarket solutions for commercial vehicle and industrial
markets. Mr. Kanan holds a Bachelor of Arts degree in Accounting from Michigan State University and became a CPA in 1987.



David Monteith – Vice President
of Research and Development. Dr. David Monteith, age 54, was appointed Vice President of Research and Development in October
2014. Prior to joining Avadel, Dr. Monteith was employed from 2009 to 2014 at Merck & Co., Inc., a global healthcare solutions
company, where he held the position of Associate Vice President of Pharmaceutical Development for Emerging Markets. From 2000 to
2009, Dr. Monteith was employed by Schering-Plough Corporation, a pharmaceutical company that merged with Merck & Co., Inc.
in November 2009 in various positions from Associate Director, Pharmaceutical Development to Senior Director, Product Value Enhancement.
With over 25 years of experience in the pharmaceutical industry, Dr. Monteith has held senior leadership roles in the areas of
drug delivery and pharmaceutical drug product development. Dr. Monteith is a graduate in Pharmacy from the University of Strathclyde,
Glasgow where he also obtained his Ph.D. from the Department of Pharmaceutics. He later also received an MBA from the University
of Warwick, UK.



David P. Gusky – Corporate Controller
and Chief Accounting Officer. David P. Gusky, age 41, was appointed Corporate Controller and Chief Accounting Officer of Avadel
in December 2015. Prior to joining Avadel, Mr. Gusky was employed by Sigma-Aldrich Corp. from May 2006 until November 2015, where
he served as Director of Financial Planning & Analysis from November 2013 until November 2015. Sigma-Aldrich was a life science
and high technology company which was acquired by Merck KGaA, a health care, life science and performance materials company based
in Germany, in November 2015. Mr. Gusky began his career at the international accounting firm Deloitte & Touche, and also held
finance management positions with Solutia, Inc., a global manufacturer of performance materials and specialty chemicals. Mr. Gusky
holds Bachelors of Science degrees in Accountancy and Finance and a Masters of Accountancy from the of Missouri-Columbia.



Section 16(a) Beneficial Ownership Reporting
Compliance



Section 16(a) of the Exchange Act requires
the Company’s directors, executive officers and persons beneficially owning more than ten percent of a registered class of
the Company’s equity securities to file reports of beneficial ownership and changes in such ownership on Forms 3, 4 and 5
with the SEC and the NYSE. These persons are also required to furnish the Company with copies of all Forms 3, 4 and 5 that they
file. Based solely on the Company’s review of the copies of such Forms it has received, the Company believes that all of
its executive officers, directors and greater than ten percent beneficial owners complied with all filing requirements applicable
to them during the calendar year ended December 31, 2017, other than (i) the filing of a Form 4 for Ms. Sandra Hatten reporting
two transactions, which was inadvertently filed late on September 15, 2017 on behalf of Ms. Hatten, and (ii) the filing of a Form
4 for Mr. Dave Gusky reporting one transaction, which was inadvertently filed late on March 5, 2018 on behalf of Mr. Gusky.



| | Item 11. | Executive Compensation.
| | -------- | -----------------------



Director Compensation



Non-Employee Director Compensation



We compensate our non-executive
directors with a basic cash fee plus supplementary fees to chairpersons and for meeting attendance. The amount of each component
of such director cash compensation may change from year to year, and is generally established by the Board in conjunction with
our annual general meeting of shareholders for the period until the next annual general meeting. The cash fees we pay under these
policies must stay within an aggregate maximum limit on cash fees paid to our directors during any calendar year which is approved
by our shareholders at each annual general meeting. In June 2017, the director cash fees were established as follows for the period
until our annual general shareholders meeting in 2018: €32,750 per each non-executive director; supplementary fees of €40,000
to Ambassador Craig Stapleton as the Chairman of the Board, €20,000 to Mr. Peter Thornton as the Chair of the Audit Committee,
€10,000 to Dr. Francis Fildes as the Chair of the Compensation Committee, and €10,000 to Mr. Ben Van Assche as the Chair
of the Nomination and Corporate Governance Committee; and meeting attendance fees of €2,000 per meeting attended in person
or telephonically up to a limit of €16,000. In addition, at our general meeting of shareholders in 2017, our shareholders
approved the issuance of stock options to purchase 175,000 ordinary shares to our directors, which were distributed as described
in footnote (2) to the “Director Compensation” table below. In addition, at our general meeting of shareholders in
2017, our shareholders approved the issuance of stock options to purchase 175,000 ordinary shares to our directors, which were
distributed as described in footnote (2) to the “Director Compensation” table below.



-7-







The following table
presents information relating to total compensation of our directors for the year ended December 31, 2017. The following table
does not present information for Mr. Anderson, our Chief Executive Officer and President, who did not receive additional compensation
as a director in 2017 and whose compensation is included in the Summary Compensation Table elsewhere in this Form 10-K/A.



|Name (1)                      |  | Fees
    Earnedor Paid in     Cash($)(1) |         |  | StockAwards($)(2) |  |         | Total Compensation ($) | 
|----------------------------- |  | ---------------------------------------- | ------- |  | ----------------- |  | ------- | ---------------------- | 
|                              |  |                                          |         |  |                   |  |         |                        | 
|Ambassador Craig R. Stapleton |  |                                          | 102,548 |  |                   |  | 210,000 |                        | 
|Peter Thornton                |  |                                          | 70,908  |  |                   |  | 210,000 |                        | 
|Francis J.T. Fildes           |  |                                          | 68,648  |  |                   |  | 210,000 |                        | 
|Christophe Navarre            |  |                                          | 57,348  |  |                   |  | 210,000 |                        | 
|Benoit Van Assche             |  |                                          | 68,648  |  |                   |  | 210,000 |                        | 



| | (1) | Fees earned or paid in cash were translated to U.S. Dollars at the rate of 1.13 U.S. Dollars per
Euro.
| | --- | ------------------------------------------------------------------------------------------------------



| | (2) | On June 28, 2017, each of the non-employee directors were awarded stock options to purchase 35,000
ordinary shares at an exercise price of $10.51 under the Company’s Omnibus Incentive Compensation Plan. The compensation
represents the grant date fair value computed by us for financial reporting purposes, computed in accordance with FASB ASC Topic
718. For a full description of the assumptions we use in computing these amounts, see Note 16 to our consolidated financial statements
for the year ended December 31, 2017 which are included in our annual report on Form 10-K filed with the SEC on March 16, 2018.
All of the foregoing stock options will vest in a one-year period following the award date.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Executive Compensation



Compensation Discussion
and Analysis



In this Compensation
Discussion and Analysis, we give an overview and analysis of our compensation philosophy, our compensation program, the decisions
we made in 2017 under those programs with respect to our named executive officers. Included in this discussion is specific information
about the compensation earned or paid in 2016 and 2017 to the following named executive officers: (i) the individual who served
as Chief Executive Officer of the Company during 2017, (ii) the individual who served as Chief Financial Officer during 2017, and
(iii) the next three most highly compensated executive officers of the Company who received total compensation of $100,000 or more
during the fiscal year ended December 31, 2017 (the “Named Executive Officers”). Our Named Executive Officers for 2017
are:



|Name                   |  | Position                                                      
|---------------------- |  | --------------------------------------------------------------
|Michael S. Anderson    |  | Chief Executive Officer                                       
|Gregory J. Divis       |  | Executive Vice President, Chief Operating Officer             
|Michael F. Kanan       |  | Senior Vice President and Chief Financial Officer             
|Phillandas T. Thompson |  | Senior Vice President, General Counsel and Corporate Secretary
|David Monteith         |  | Vice President, Research and Development                      



Compensation
Philosophy and Objectives



The Compensation Committee’s
executive compensation programs are designed to: (i) attract, retain and motivate executives with significant industry knowledge
and the experience and leadership capability necessary for us to achieve success; and (ii) align incentives for our named executive
officers with our corporate strategies and business objectives and goals; and (iii) achieve key strategic performance measures
aligned with the long-term interests of our shareholders.



Compensation
Components



Our executive compensation
program has three primary components: base salary, annual cash incentive awards and equity awards.



-8-







| | • | Base Salary. We fix the base salary of each of our executive officers at a level we believe
enables us to hire and retain individuals in a competitive environment and rewards satisfactory individual performance and a satisfactory
level of contribution to our overall business goals. We take into account the base salaries paid by similarly-situated companies
in our peer group and, to the extent practicable, we set base salary levels for similarly-situated executives within the Company
at comparable levels to avoid divisiveness and encourage teamwork, collaboration, and a cooperative working environment.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | Cash Incentive Awards. We provide annual cash incentive awards that are based upon the achievement
of corporate and individual objectives established by the Compensation Committee and the Board of Directors. These cash incentive
awards are designed to focus our executive officers on achieving key clinical, regulatory, commercial, operational, strategic and
financial objectives.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | Equity Awards. We use stock options and restricted shares to reward long-term performance.
These equity awards are intended to provide significant incentive value for each executive officer if the Company performance is
outstanding and the Company achieves its long-term goals to align executive compensation with long-term shareholder interests.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



In addition to the
primary components of compensation described above, we provide our Named Executive Officers with employee benefits that are generally
available to our salaried employees. These benefits include health and medical benefits, flexible spending plans, matching 401(k)
contributions and group life insurance.



We have also entered
into agreements with our Named Executive Officers under which they are provided certain benefits in the event their employment
with the Company is terminated without cause or by the Named Executive Officer for good reason, following a change in control of
the Company.



Compensation
Policies and Process



The Compensation Committee
has oversight of our compensation philosophy and programs and annually reviews and recommends all compensation decisions relating
to our Chief Executive Officer, our Named Executive Officers and all other executive officers of the Company. The Chief Executive
Officer provides specific information to the committee relative to the performance of the other members of the executive management
team. However, the Chief Executive Officer is always excused from the Compensation Committee meetings when his compensation or
employment is discussed. The Compensation Committee considers any recommendations by the Chief Executive Officer; however, the
committee recommends final compensation for all executives. All compensation decisions are assessed within the framework of the
Company’s financial position and general economic conditions. Our Board typically reviews and approves the compensation decisions
made by the Compensation Committee.



Our Compensation Committee
has engaged the Radford Consulting (“Radford”), an Aon Hewitt company specializing in executive compensation, as its
independent compensation consultant. In connection with the Compensation Committee’s executive compensation decisions for
2017, Radford reviewed and advised on principal aspects of our executive compensation program and performed the following services:



| | • | conducted a competitive assessment of the Company’s then current executive compensation arrangements,
including analyzing peer group proxy statements, compensation survey data, and other publicly available data;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | provided recommendations on the composition of the Company’s peer group; and
| | - | ----------------------------------------------------------------------------



| | • | reviewed and advised on equity compensation and on industry best practices.
| | - | ---------------------------------------------------------------------------



The Compensation Committee
has determined that the work of Radford and the individual compensation advisors employed by Radford does not create any conflict
of interest. In making that determination, the Compensation Committee took into consideration the following factors: (i) the provision
of other services to the Company by the consultant; (ii) the amount of fees the Company paid the consultant as a percentage of
the consultant’s total revenue; (iii) the consultant’s policies and procedures that are designed to prevent conflicts
of interest; (iv) any business or personal relationship of the consultant or the individual compensation advisors employed by the
consultant with any Company executive officer; (v) any business or personal relationship of the individual compensation advisors
with any member of the Compensation Committee; and (vi) any Company stock owned by the consultant or the individual compensation
advisors employed by the consultant.



-9-







Peer Group



In an effort to provide
competitive total compensation to our executive officers, the Compensation Committee approved a group of comparable companies as
our peer group as recommended by Radford. The peer group was selected on the basis of similarity to the Company on the following
criteria: business comparability, stage of product development and commercialization, number of employees, market capitalization
and revenue. The following companies were identified as our “peer group” for 2017:



|2017 Peer Group               
|------------------------------
|                              
|Acorda Therapeutics           
|AMAG Pharmaceuticals, Inc.    
|Amarin Corporation            
|ANI Pharmaceuticals           
|Arena Pharmaceuticals, Inc.   
|BioCryst Pharmaceuticals, Inc.
|BioDelivery Sciences          
|DepoMed Inc.                  
|Eagle Pharmaceuticals, Inc.   
|ImmunoGen, Inc.               



Base Salary



The Company provides
base salaries to attract and retain executives with the proper experiences and skill sets required to assist us in achieving our
specific business objectives, as well as our future growth and success. Base salaries provide a guaranteed base level of compensation
that reflects a belief that base salary for senior executive officers should be targeted at market-competitive levels. Base salaries
for a particular fiscal year are generally established at the end of the prior year. In establishing the base salaries for 2017,
the Compensation Committee considered each Named Executive Officer’s role and level of responsibility at the Company, recent
individual performance, perceived impact on Company results and overall Company performance. Based on the peer group and other
market data presented by Radford, the Compensation Committee noted that the base salaries of our Named Executive Officers are currently
positioned at the market 25th percentile in the aggregate. However, given our transition from a non-commercial to a
commercial company, the Compensation Committee desires to implement a revised compensation program in the future designed to gradually
migrate our Named Executive Officers base salaries to the 50th percentile of the base salaries paid to similarly situated
officers at our peer group companies. The base salaries of our Named Executive Officers during 2016 and 2017 were as follows: Michael
S. Anderson – $565,500 in 2016 and $581,946 in 2017, an increase of 3.0%; Gregory J. Divis (who joined the Company in January
2017) – $375,000 in 2017; Michael F. Kanan – $325,000 in 2016 and $357,500 in 2017, an increase of 10.0%; Phillandas
T. Thompson – $297,052 in 2016 and $326,757 in 2017, an increase of 10.0%; and David Monteith – $283,250 in 2016 and
$311,575 in 2017, an increase of 10.0%.



Annual Cash Incentive



The goal of the annual
cash incentive program in 2017 was to align a meaningful portion of the total compensation potential for the Named Executive Officers
to the achievement of specified quantitative and qualitative Company performance targets, as well as individual performance targets.
The achievement of these targets advances the Company’s specific business objectives and result in long-term shareholder
value. The target levels of the annual cash incentive awards were established as part of the Named Executive Officer’s individual
employment agreements. Each of these employment agreements provide that the Named Executive Officer will receive an annual cash
incentive award determined at the discretion of the Compensation Committee and the Board based on the Company’s performance
against its objectives and individualized objective and subjective criteria, with a target award amount equal to a percentage of
the Named Executive Officer’s base salary. The award criteria include specific objectives, relating to the achievement of
clinical, regulatory, commercial, business and/or financial milestones.



Our approved 2017 corporate
goals consisted of:



| | • | generate target $175 million in revenues and $38 million of adjusted operating income, and $18
million of adjusted operating cash flow;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------



| | • | advance the sodium oxybate clinical program, focusing on patient enrollment numbers and the scale
up and manufacture of registration stability batches;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | complete acquisition or licensing opportunities to increase sales on an annualized basis equal
to $50 million;
| | - | --------------------------------------------------------------------------------------------------------------



-10-







| | • | advance the Company’s internal development pipeline; and
| | - | --------------------------------------------------------



| | • | achieve profitable sales level of the pediatric products.
| | - | ---------------------------------------------------------



The Compensation Committee
determined that the Company’s corporate performance score was 84.5% for 2017 based solely on the Compensation Committee’s
assessment of the Company’s level of achievement against the approved 2017 corporate performance goals set forth above.



Chief Executive
Officer. The Compensation Committee awarded an annual cash incentive with respect to 2017 for our Chief Executive Officer in
the amount of $279,334. Such amount was determined by the Committee in December 2017 based on an assessment of the factors listed
above and other factors including:



| | • | the Company’s achievement with respect to pre-established Company financial and strategic
objectives, which included: (i) achievement of a revenue target, (ii) achievement of meaningful business development in completing
a company acquisition, (iii) successful completion of action plan to reincorporate to Ireland, and (iv) achievement of the Company’s
readiness to implement its new identity; and
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | achievement of individual performance targets that were pre-established, which included recruitment
of key members of our management team, as well as providing overall leadership and vision for our management team to execute upon.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Other Named Executive
Officers. The process for determining the annual cash incentive for our other Named Executive Officers, is generally similar
to what is described above with respect to our Chief Executive Officer. For 2017, the Compensation Committee took into account
the Company’s performance with respect to the financial and strategic performance goals discussed above. The Compensation
Committee assessed the individual performance of the other Named Executive Officers and also considered the recommendations of
our Chief Executive Officer. The other Named Executive Officers reported directly to our Chief Executive Officer and so, the Compensation
Committee believes, the Chief Executive Officer was in a position to provide a meaningful assessment of their capabilities and
contributions to the Company.



The Compensation Committee
determined 2017 annual cash incentives for the other Named Executive Officers in the following amounts: Gregory J. Divis –
$158,438; Michael F. Kanan – $120,835; Phillandas T. Thompson – $110,444; and David Monteith – $99,081.



Equity Compensation



The Compensation Committee
believes that equity compensation awards help to align the interests of our executive officers with those of shareholders because
the value of the equity awards to the recipient increases only with the appreciation of the price of our ordinary shares. Furthermore,
the Compensation Committee believes granting equity awards that vest over time encourages executives to remain with the Company.
The authority to grant equity awards to our executive officers lies with the Compensation Committee and Board. The Compensation
Committee takes into consideration the peer group data provided by Radford and the recommendations of our Chief Executive Officer
(other than for himself). Generally, the Compensation Committee has granted stock options to our executive officers upon commencement
of their employment with the Company. These initial stock options vest over a four year period and are in connection with the executive
officer’s employment agreement. At least annually, typically in December, the Compensation Committee considers annual equity
awards for our executive officers. These awards consist of both stock options and restricted shares.



In determining the
number of stock options and restricted shares to grant to a particular Named Executive Officer, the Compensation Committee takes
into account numerous factors, including: the executive’s role and level of responsibility within the Company, the Company’s
performance with respect to the financial and strategic goals and objectives for that year, and comparative peer group data as
presented by Radford. The Compensation Committee has not adopted any formal policies or guidelines for determining the allocation
of stock options versus restricted shares. However, in general, the Compensation Committee will recommend a mix of equity awards
more weighted towards stock options than restricted shares principally because the Compensation Committee recognizes that restricted
shares provide immediate value to recipients upon vesting and therefore involve less risk than stock options. In 2017, the Compensation
Committee awarded the following restricted shares under the Company’s Omnibus Incentive Compensation Plan: 25,000 to the
Chief Executive Officer; 22,500 to Gregory J. Divis; 18,000 to Michael F. Kanan; 18,000 to Phillandas T. Thompson; and 15,000 to
David Monteith.



In 2017, the Compensation
Committee awarded the Chief Executive Officer stock options to purchase 150,000 ordinary shares at an exercise price of $8.95,
and awarded to the other Named Executive Officers stock options to purchase the following numbers of ordinary shares each at an
exercise price of $8.95 per share: 100,000 to Gregory J. Divis, 80,000 to Michael F. Kanan, 80,000 to Phillandas T. Thompson; and
60,000 to David Monteith. All of the foregoing stock options will vest in equal amounts over a four-year period following the award
date.



-11-







Compensation
Risk Assessment



The Company regularly
reviews compensation plans and practices to ensure they are appropriately structured and aligned with business objectives, and
not designed to encourage executives to take unwarranted risks. Specifically, the overall design of the compensation philosophy
and plans mitigate risks because: (1) the financial performance objectives of the short and long-term incentive plans are reviewed
and approved annually by the Board; (2) the plans consist of multiple performance objectives, thus lessening the focus on any one
in particular; and (3) short and long-term incentive payouts are capped for all participants.



General Employee
Benefits



Avadel offers competitive
health, dental and life insurance and vacation pay, generally for all employees. The senior executives are eligible to participate
in all of the above programs. In addition, the senior executives are eligible to receive matching 401(k) plan contributions on
the same basis as other employees.



Severance and
Change-in-Control Benefits



Pursuant to employment
agreements, each of our Named Executive Officers has a provision in his or her employment agreement with the Company that entitles
such Named Executive Officer to certain specified benefits in the event of termination of their employment under specified circumstances,
including termination following a change in control of the Company. These benefits are described in the “Employment Agreement”
section below, and certain estimates of these severance and change-in-control benefits are provided in “Estimated Payments
Upon Termination or Change in Control” below.



Retirement Benefits



The Company believes
that offering competitive retirement benefits is important to attract and retain top executives. The Company’s U.S.-based
executives participate in a traditional defined contribution 401(k) plan. For our Company’s 401(k) plan, the Company generally
contributed approximately $10,800 to each eligible executive’s 401(k) account during 2017, which was the maximum contribution
match allowable under the Company’s 401(k) Plan, provided the participant contributed the maximum in order to receive the
maximum match and contributed based off of $270,000 of wages, the maximum allowable under the IRS limits.



For executives not
based in the U.S., the Company has taken steps in recent years to align certain features of its pension or retirement plans, recognizing
that benefit formulas are driven by local market competition and trends. Additional details regarding retirement benefits are provided
in the tables below entitled “Summary Compensation Table.”



Tax Considerations



Section 162(m) of the
Internal Revenue Code generally limits to $1 million the U.S. federal tax deductibility of compensation paid in one year to any
employee. Performance-based compensation is not subject to the limits on deductibility of Section 162(m), provided that such compensation
meets certain requirements, including shareholder approval of material terms of compensation.



The Compensation Committee
attempts to provide the Named Executive Officers with incentive compensation programs that will preserve the tax deductibility
of compensation paid by the Company, to the extent reasonably practicable and to the extent consistent with the Company’s
other compensation objectives. The Compensation Committee believes, however, that shareholder interests are best served by not
restricting the Compensation Committee’s discretion and flexibility in structuring compensation programs, even though such
programs may result in certain non-deductible compensation expenses.



Our compensation arrangements
for executive officers, including our Named Executive Officers, do not provide tax gross-ups for any type of payments, including
payments for severance or in connection with a change of control.



Securities Trading Policy



The Company has a policy
that prohibits executive officers and directors from trading in the Company’s securities while aware of material non-public
information, or engaging in hedging transactions or short sales and trading in “puts” and “calls” involving
the Company’s securities. This policy is described in our Standards of Business Conduct, which may be viewed on our website
at www.Avadel.com in the “Investors” section. In addition, executive officers and directors are prohibited from pledging
the Company’s securities.



-12-







2017 Compensation of Named Executives
Officers



Summary
Compensation Table



The following table
sets forth the compensation paid or accrued during the fiscal years ended December 31, 2017, 2016 and 2015 to our Named Executive
Officers:



|                                      |  |      |  |                         |         |  |               |  |   | Equity-based
    Incentive Plan Compensation                                                           |  |  |                              |  |  |                                                      |           |  |                                      | 
|------------------------------------- |  | ---- |  | ----------------------- | ------- |  | ------------- |  | - | ------------------------------------------------------------------------------------------------------ |  |  | ---------------------------- |  |  | ---------------------------------------------------- | --------- |  | ------------------------------------ | 
|Name and
    Principal Position       |  | Year |  | Base
    Salary ($) (1) |         |  | Bonus
    ($) |  |   | Stock Awards   ($)
                                                                                (2) |  |  | Option
    Awards   ($)  (3) |  |  | Non-Equity
    Incentive Plan Compensation   ($) (4) |           |  | All
    Other Compensation   ($) (5) | 
|                                      |  |      |  |                         |         |  |               |  |   |                                                                                                        |  |  |                              |  |  |                                                      |           |  |                                      | 
|Michael S. Anderson                   |  | 2017 |  |                         | 581,946 |  |               |  | - |                                                                                                        |  |  | 223,750                      |  |  |                                                      | 757,500   |  |                                      | 
|Chief Executive                       |  | 2016 |  |                         | 565,500 |  |               |  | - |                                                                                                        |  |  | 991,500                      |  |  |                                                      | 1,180,000 |  |                                      | 
|Officer                               |  | 2015 |  |                         | 550,000 |  |               |  | - |                                                                                                        |  |  | -                            |  |  |                                                      | 1,664,000 |  |                                      | 
|                                      |  |      |  |                         |         |  |               |  |   |                                                                                                        |  |  |                              |  |  |                                                      |           |  |                                      | 
|Gregory J. Divis                      |  | 2017 |  |                         | 375,000 |  |               |  |   |                                                                                                        |  |  | 201,375                      |  |  |                                                      | 505,000   |  |                                      | 
|Executive Vice President,             |  | 2016 |  |                         | -       |  |               |  | - |                                                                                                        |  |  | -                            |  |  |                                                      | 885,000   |  |                                      | 
|Chief Operating Officer               |  | 2015 |  |                         | -       |  |               |  | - |                                                                                                        |  |  | -                            |  |  |                                                      | -         |  |                                      | 
|                                      |  |      |  |                         |         |  |               |  |   |                                                                                                        |  |  |                              |  |  |                                                      |           |  |                                      | 
|Michael F. Kanan                      |  | 2017 |  |                         | 357,500 |  |               |  | - |                                                                                                        |  |  | 161,100                      |  |  |                                                      | 404,000   |  |                                      | 
|Senior Vice President                 |  | 2016 |  |                         | 325,000 |  |               |  | - |                                                                                                        |  |  | 187,200                      |  |  |                                                      | 590,000   |  |                                      | 
|and Chief Financial Officer           |  | 2015 |  |                         | 33,854  |  |               |  | - |                                                                                                        |  |  | -                            |  |  |                                                      | 935,000   |  |                                      | 
|                                      |  |      |  |                         |         |  |               |  |   |                                                                                                        |  |  |                              |  |  |                                                      |           |  |                                      | 
|Phillandas T. Thompson                |  | 2017 |  |                         | 326,757 |  |               |  | - |                                                                                                        |  |  | 161,100                      |  |  |                                                      | 404,000   |  |                                      | 
|Senior Vice President,                |  | 2016 |  |                         | 297,052 |  |               |  | - |                                                                                                        |  |  | 459,000                      |  |  |                                                      | 590,000   |  |                                      | 
|General Counsel & Corporate Secretary |  | 2015 |  |                         | 288,400 |  |               |  | - |                                                                                                        |  |  | -                            |  |  |                                                      | 832,000   |  |                                      | 
|                                      |  |      |  |                         |         |  |               |  |   |                                                                                                        |  |  |                              |  |  |                                                      |           |  |                                      | 
|David Monteith                        |  | 2017 |  |                         | 311,575 |  |               |  |   |                                                                                                        |  |  | 134,250                      |  |  |                                                      | 303,000   |  |                                      | 
|Vice President of                     |  | 2016 |  |                         | 283,250 |  |               |  | - |                                                                                                        |  |  | 359,850                      |  |  |                                                      | 442,500   |  |                                      | 
|Research & Development                |  | 2015 |  |                         | 275,000 |  |               |  | - |                                                                                                        |  |  | -                            |  |  |                                                      | 291,200   |  |                                      | 



| | (1) | Represents salaries before any employee contributions under our 401(k) Plan.
| | --- | ----------------------------------------------------------------------------



| | (2) | Stock awards represent equity compensation for meeting Company and personal performance targets
or for having signed an employment contract with the Company. Represents the grant date fair value computed by us for financial
reporting purposes, computed in accordance with FASB ASC Topic 718. For a full description of the assumptions we use in computing
these amounts, see Note 16 to our consolidated financial statements for the year ended December 31, 2017 which are included in
our annual report on Form 10-K filed with the SEC on March 16, 2018.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Option awards represent equity compensation for meeting Company and personal performance targets
or for having signed an employment contract with the Company. Represents the grant date fair value computed by us for financial
reporting purposes, computed in accordance with FASB ASC Topic 718. For a full description of the assumptions we use in computing
these amounts, see Note 16 to our consolidated financial statements for the year ended December 31, 2017 which are included in
our annual report on Form 10-K filed with the SEC on March 16, 2018. The actual value a Named Executive Officer may receive depends
on market prices and there can be no assurance that the amounts reflected in the Option Awards column will actually be realized.
No gain to a named executive officer is possible without an appreciation in stock value after the date of grant.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | Non-equity incentive plan compensation represents cash bonuses for meeting Company and personal
performance targets.
| | --- | --------------------------------------------------------------------------------------------------------------------



| | (5) | See the All Other Compensation Table below.
| | --- | -------------------------------------------



-13-







All
Other Compensation Table



The table below reflects
the types and dollar amounts of perquisites, additional compensation and other personal benefits provided to the named executive
officers during fiscal year 2017. For purposes of computing the dollar amounts of the items listed below, we used the actual out-of-pocket
costs to us of providing the perquisite or other personal benefit to the named executive officer.



|Name                   |  | Year |  | 401K Match ($) |        |  | Car Allowance ($) |  |        | Personal Tax Preparation Fees ($) |  |  | Total All Other Compensation   ($) | 
|---------------------- |  | ---- |  | -------------- | ------ |  | ----------------- |  | ------ | --------------------------------- |  |  | ---------------------------------- | 
|                       |  |      |  |                |        |  |                   |  |        |                                   |  |  |                                    | 
|                       |  | 2017 |  |                | 10,800 |  |                   |  | 8,091  |                                   |  |  | -                                  | 
|Michael S. Anderson    |  | 2016 |  |                | 10,600 |  |                   |  | 7,847  |                                   |  |  | -                                  | 
|                       |  | 2015 |  |                | 10,600 |  |                   |  | 6,960  |                                   |  |  | 3,067                              | 
|                       |  | 2017 |  |                | 10,800 |  |                   |  | 12,000 |                                   |  |  | -                                  | 
|Gregory J. Divis       |  | 2016 |  |                | -      |  |                   |  | -      |                                   |  |  | -                                  | 
|                       |  | 2015 |  |                | -      |  |                   |  | -      |                                   |  |  | -                                  | 
|                       |  | 2017 |  |                | 10,800 |  |                   |  | 12,000 |                                   |  |  | -                                  | 
|Michael F. Kanan       |  | 2016 |  |                | 10,600 |  |                   |  | 12,000 |                                   |  |  | -                                  | 
|                       |  | 2015 |  |                | -      |  |                   |  | -      |                                   |  |  | -                                  | 
|                       |  | 2017 |  |                | 10,800 |  |                   |  | 9,000  |                                   |  |  | -                                  | 
|Phillandas T. Thompson |  | 2016 |  |                | 10,600 |  |                   |  | 9,000  |                                   |  |  | -                                  | 
|                       |  | 2015 |  |                | 10,600 |  |                   |  | 9,000  |                                   |  |  | -                                  | 
|                       |  | 2017 |  |                | 10,800 |  |                   |  | -      |                                   |  |  | -                                  | 
|David Monteith         |  | 2016 |  |                | 10,600 |  |                   |  | -      |                                   |  |  | -                                  | 
|                       |  | 2015 |  |                | -      |  |                   |  | -      |                                   |  |  | -                                  | 



Grants
of Plan-Based Awards 2017



The following table
presents information regarding grants of plan-based awards to the named executive officers during the year ended December 31, 2017:



|                       |  |                |  | Estimated Possible Payouts
    Under Non-Equity Incentive Plan Awards(1) |   |  | Estimated Future Payouts
    Under Equity Incentive Plan Awards (1) |  |         | All Other Stock
 Awards:
    Number of Shares of  Stock or |  |  | Exercise or Base Price |  |  | Grant Date Fair Value |  
|---------------------- |  | -------------- |  | ------------------------------------------------------------------------ | - |  | ------------------------------------------------------------------- |  | ------- | ---------------------------------------------------------- |  |  | ---------------------- |  |  | --------------------- | -
|Name                   |  | Grant
    Date |  | Threshold
    ($)                                                        |   |  | Target
    ($)                                                      |  |         | Maximum
    ($)                                            |  |  | Threshold
    (#)      |  |  | Target
    (#)        |  
|                       |  |                |  |                                                                          |   |  |                                                                     |  |         |                                                            |  |  |                        |  |  |                       |  
|Michael S. Anderson    |  | 12/12/2017     |  |                                                                          | - |  |                                                                     |  | 349,168 |                                                            |  |  | -                      |  |  |                       | -
|Gregory J. Divis       |  | 12/12/2017     |  |                                                                          | - |  |                                                                     |  | 187,500 |                                                            |  |  | -                      |  |  |                       | -
|Michael F. Kanan       |  | 12/12/2017     |  |                                                                          | - |  |                                                                     |  | 143,000 |                                                            |  |  | -                      |  |  |                       | -
|Phillandas T. Thompson |  | 12/12/2017     |  |                                                                          | - |  |                                                                     |  | 130,703 |                                                            |  |  | -                      |  |  |                       | -
|David Monteith         |  | 12/12/2017     |  |                                                                          | - |  |                                                                     |  | 124,630 |                                                            |  |  | -                      |  |  |                       | -



| | (1) | The Compensation Committee has not established thresholds or maximum levels associated with non-equity
and equity incentive plan awards.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------



-14-







The following table sets
forth specified information concerning stock options stock awards for each of the named executive officers outstanding as of December
31, 2017:



|                       |  |            |  | Outstanding Equity Awards at Fiscal Year-End 2017                       |         |              |                                                                          
|---------------------- |  | ---------- |  | ----------------------------------------------------------------------- | ------- | ------------ | -------------------------------------------------------------------------
|                       |  |            |  | Option Awards                                                           |         | Stock Awards |                                                                          
|Name                   |  | Grant Date |  | Number of Securities Underlying Unexercised Options (#) Exercisable (1) |         |              | Number of Securities Underlying Unexercised Options (#) Unexercisable (1)
|                       |  |            |  |                                                                         |         |              |                                                                          
|Michael S. Anderson    |  | 3/12/2012  |  |                                                                         | 275,000 |              |                                                                          
|                       |  | 2/1/2013   |  |                                                                         | 80,500  |              |                                                                          
|                       |  | 12/11/2014 |  |                                                                         | 150,000 |              |                                                                          
|                       |  | 12/11/2014 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/10/2015 |  |                                                                         | 100,000 |              |                                                                          
|                       |  | 8/10/2016  |  |                                                                         | -       |              |                                                                          
|                       |  | 12/14/2016 |  |                                                                         | 50,000  |              |                                                                          
|                       |  | 12/14/2016 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|Gregory J. Divis       |  | 12/14/2016 |  |                                                                         | 37,500  |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|Michael F. Kanan       |  | 10/28/2015 |  |                                                                         | 50,000  |              |                                                                          
|                       |  | 12/14/2016 |  |                                                                         | 25,000  |              |                                                                          
|                       |  | 12/14/2016 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|Phillandas T. Thompson |  | 12/12/2013 |  |                                                                         | 100,000 |              |                                                                          
|                       |  | 12/11/2014 |  |                                                                         | 71,250  |              |                                                                          
|                       |  | 12/11/2014 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/10/2015 |  |                                                                         | 50,000  |              |                                                                          
|                       |  | 8/10/2016  |  |                                                                         | -       |              |                                                                          
|                       |  | 12/14/2016 |  |                                                                         | 25,000  |              |                                                                          
|                       |  | 12/14/2016 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|David Monteith         |  | 12/11/2014 |  |                                                                         | 82,500  |              |                                                                          
|                       |  | 12/11/2014 |  |                                                                         |         |              |                                                                          
|                       |  | 12/10/2015 |  |                                                                         | 17,500  |              |                                                                          
|                       |  | 8/10/2016  |  |                                                                         | -       |              |                                                                          
|                       |  | 12/14/2016 |  |                                                                         | 18,750  |              |                                                                          
|                       |  | 12/14/2016 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          
|                       |  | 12/12/2017 |  |                                                                         | -       |              |                                                                          



| | (1) | Options become exercisable as to 25% of the ADSs on each of the first four anniversaries after
the applicable grant date.
| | --- | -------------------------------------------------------------------------------------------------------------------------



| | (2) | Stock awards granted prior to 8/10/2016 become vested on the fourth anniversary of the grant date
for U.S. residents. In addition, if the beneficiary remains an employee of the Company at the second anniversary of the grant date,
the beneficiary may take claim to the shares on the fourth anniversary period even if the beneficiary is not employed with the
Company after the second anniversary. Stock awards granted on 8/10/2016 and12/14/2016 become vested on the second anniversary of
the grant date and are issued on such second anniversary even if the beneficiary is not employed with the Company subsequent to
the grant date. Stock awards granted on 12/12/2017 and later become vested as to 2/3 of the grant on the second anniversary of
the grant date and the remaining 1/3 of the grant on the third anniversary of the grant fate, with vesting of these restricted
shares subject to the employee remaining in continuous service until the applicable anniversary of the date of grant.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



-15-







Employment Agreements



We have written employment
agreements with each of our Named Executive Officers. Each employment agreement provides that the individual’s employment
will continue until either we or the Named Executive Officer provides written notice of termination in accordance with the terms
of the agreement. In addition, each of these agreements prohibit the Named Executive Officer from disclosing confidential information
and competing with us during the term of their employment with the Company and for a specified time period thereafter. The agreements
also contain customary non-solicitation and non-disparagement provisions. Under the terms of their respective employment agreements,
each of the Named Executive Officers is entitled to receive an annual base salary, subject to annual review, an annual cash incentive
and an annual equity award, each component of which is subject to the discretion of our board.



Payments upon
Termination of Employment



Pursuant to their employment agreements,
each of our Named Executive Officers (other than Mr. Monteith, whose severance benefit is described below) is entitled to certain
severance benefits in the event he or she terminates his or her employment for “Good Reason” or if his or her employment
is terminated by the Company for any reason other than for “Cause,” including non-renewal by the Company at the end
of the employment term. Upon such a termination, the Named Executive Officer (other than Mr. Monteith) is entitled to receive (1)
base salary for a period of 12 months (18 months in the case of Mr. Anderson); (2) all accrued but unpaid bonuses for any completed
fiscal year and vacation pay, expense reimbursement and other benefits due under any Company-provided benefit plans, policies and
arrangements; and (3) payment of monthly COBRA health insurance premiums for up to 12 months (18 months in the case of Mr. Anderson).



In addition, if such a termination occurs
during a Change in Control Period (as defined below), the Named Executive Officer (other than Mr. Monteith) is entitled to receive
amounts provided in (1) and (3) of the above paragraph plus (i) the highest of (x) their target bonus in effect for the fiscal
year in which the applicable change in control occurs, or (y) their target bonus in effect for the fiscal year in which the termination
of employment occurs; or (z) their actual bonus for performance during the calendar year prior to the calendar year during which
the termination of employment occurs; (ii) the amount provided in (2) of the above paragraph, as applicable; and (iii) the immediate
vesting of 100% of their outstanding and unvested stock options and any other equity awards under the Company’s compensation
plans. For purposes of these agreements:



| | • | “Good Reason” is defined as (i) the failure of the Company to timely pay to the employee
any compensation owed under the agreement; (ii) the Company’s diminution in the employee’s authority, duties or responsibilities
in any material respect or the Company’s assignment to the employee of duties that are materially inconsistent with the duties
stated in the agreement; (iii) the relocation of the place of the employee’s employment more than sixty (60) miles outside
the greater St. Louis metropolitan area; (iv) a material breach by the Company of the agreement; or (v) the failure of the Company
to have the agreement assumed in full by any successor in the case of any merger, consolidation, or sale of all or substantially
all of the assets of the Company.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



-16-







| | • | “Cause” means: (i) conviction of or plea of nolo contendere to a felony or crime involving
moral turpitude; (ii) fraud, theft, or misappropriation of any asset or property of the Company, including, without limitation,
any theft or embezzlement or any diversion of any corporate opportunity; (iii) breach of any of the material obligations contained
in the agreement; (iv) conduct materially contrary to the material policies of the Company; (v) material failure to meet the goals
and objectives established by the Company without cure within a reasonable period of time after written notice thereof; or (vi)
conduct that results in a material detriment to the Company, its program, or goals or is inimical to the Company's reputation and
interests without cure within a reasonable period of time after written notice thereof.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | “Change of Control Period” means the period beginning six (6) months prior to, and
ending eighteen (18) months following, a Change of Control.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------



| | • | “Change of Control” means the occurrence of any of the following events: (i) A change
in the ownership of the Company which occurs on the date that any one person, or more than one person acting as a group (‘Person’),
acquires ownership of the equity interests of the Company that, together with the stock held by such Person, constitutes more than
fifty percent (50%) of the total voting power of the stock of the Company; provided, however, that for purposes of this subsection,
the acquisition of additional stock by any one Person, who is considered to own more than fifty percent (50%) of the total voting
power of the stock of the Company will not be considered a Change or Control; or (ii) A change in the effective control of the
Company which occurs on the date that a majority of the members of the Board is replaced during any twelve (12) month period by
Directors whose appointment or election is not endorsed by a majority of the members of the Board prior to the date of the appointment
or election. For purposes of such definition, if any Person is considered to be in effective control of the Company, the acquisition
of additional control of the Company by the same Person will not be considered a Change of Control; or (iii) A change in the ownership
of a substantial portion of the Company's assets which occurs on the date that any Person acquires (or has acquired during the
twelve (12) month period ending on the date of the most recent acquisition by such person or persons) assets from the Company that
have a total gross fair market value equal to or more than fifty percent (50%) of the total gross fair market value of all of the
assets of the Company immediately prior to such acquisition or acquisitions.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The benefits provided
are designed to protect earned benefits in the case that one or more of such Named Executive Officers is terminated without cause
or as a result of a change in control of the Company, in order to encourage such Named Executive Officers to act in the best interests
of the shareholders at all times during the course of a change in control transaction or other significant event involving our
Company.



In the employment agreement
with Mr. Monteith, in the event his employment with the Company is terminated for any reason other than for cause, he is entitled
to severance benefits equal to (1) base salary for a period of 12 months and (2) payment of monthly COBRA health insurance premiums
for up to 12 months.



The following tables
set forth information regarding potential payments that each Named Executive Officer would have received if the Named Executive
Officer’s employment had terminated as of December 31, 2017 under the circumstances set forth below.



Termination
Payments(1)



|Name                   |  | Cash Payment ($) |           |  | Value of Benefits ($) | 
|---------------------- |  | ---------------- | --------- |  | --------------------- | 
|                       |  |                  |           |  |                       | 
|Michael S. Anderson    |  |                  | 1,152,253 |  |                       | 
|Gregory J. Divis       |  |                  | 533,438   |  |                       | 
|Michael F. Kanan       |  |                  | 478,335   |  |                       | 
|Phillandas T. Thompson |  |                  | 437,201   |  |                       | 
|David Monteith         |  |                  | 311,575   |  |                       | 



-17-







Termination
Payments in Connection with a Change in Control of the Company(2)



|Name                   |  | Cash Payment ($) |           |  | Value of Benefits ($) |  |        | Accelerationof EquityAwards ($)(3) | 
|---------------------- |  | ---------------- | --------- |  | --------------------- |  | ------ | ---------------------------------- | 
|                       |  |                  |           |  |                       |  |        |                                    | 
|Michael S. Anderson    |  |                  | 1,222,087 |  |                       |  | 31,588 |                                    | 
|Gregory J. Divis       |  |                  | 562,500   |  |                       |  | 21,204 |                                    | 
|Michael F. Kanan       |  |                  | 500,500   |  |                       |  | 21,059 |                                    | 
|Phillandas T. Thompson |  |                  | 457,460   |  |                       |  | 6,948  |                                    | 
|David Monteith         |  |                  | 311,575   |  |                       |  | 21,059 |                                    | 



| | (1) | Based on the compensation arrangements with the Named Executive Officers in effect for 2018, the
amounts payable in respect of an applicable termination during 2018 would be as follows: Michael Anderson - $899,106 cash payment
and $20,436 value of benefits; Gregory J. Divis - $425,000 cash payment and $19,174 value of benefits; Michael F. Kanan - $386,100
cash payment and $19,724 value of benefits; Phillandas T. Thompson - $365,968 cash payment and $6,500 value of benefits; and David
Monteith - $320,922 cash payment and $19,724 value of benefits.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Based on the compensation arrangements with the Named Executive Officers in effect for 2018,
                                                            the amounts payable in respect of an applicable termination during a Change in Control Period during 2018 would be as
                                                            follows: Michael Anderson - $1,258,748 cash payment, $20,436 value of benefits, and $175,250 in acceleration of equity
                                                            awards; Gregory J. Divis - $637,500 cash payment, $19,174 value of benefits, and $157,725 in acceleration of equity awards;
                                                            Michael F. Kanan - $540,540 cash payment, $19,724 value of benefits, and $126,180 in acceleration of equity awards;
                                                            Phillandas                                                             T. Thompson - $512,355 cash payment, $6,500 value of
                                                            benefits, and $126,180 in acceleration of equity awards; and David
                                                            Monteith - $320,922 cash payment and $19,724 value of benefits.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Only option awards for which the exercise price is lower than the market value of the underlying
shares are included as part of the acceleration value. Additionally, unvested restricted stock awards with employment conditions
beyond the anticipated termination date are included as part of the acceleration value based on the market value of the underlying
shares.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Compensation Committee
Report



The Compensation Committee
has reviewed and discussed the Compensation Discussion and Analysis required by Item 402(b) of Regulation S-K with management and,
based on such review and discussion, the Compensation Committee recommended to the Board that it be included in this Form 10-K/A.



| | THE COMPENSATION COMMITTEE   
| | -----------------------------
| |                              
| | Francis J.T. Fildes, Chairman
| | Christophe Navarre           
| | Craig Stapleton              
| | Benoit C. Van Assche         



The “Compensation Committee Report”
above shall not be deemed incorporated by reference by any general statement incorporating this Form 10-K/A into any filing under
the Securities Act of 1933 or under the Securities Exchange Act of 1934, as amended, except to the extent that we specifically
incorporate this information by reference, and shall not otherwise be deemed filed under such Acts.



Compensation Risk Assessment



As part of its oversight
of our executive compensation program, the Compensation Committee considers the impact of our executive compensation program, and
the incentives created by the compensation awards that it administers, on our risk profile. In addition, we review all our compensation
policies and procedures, including the incentives that they create and factors that may reduce the likelihood of excessive risk-taking,
to determine whether they present a significant risk to us. The Compensation Committee concluded that our compensation programs
are designed with the appropriate balance of risk and reward in relation to our overall
business strategy and that the balance of compensation elements discourages excessive risk-taking. The Compensation Committee,
therefore, determined that the risks arising from our compensation policies and practices for employees are not reasonably likely
to have a material adverse effect on us. The Compensation Committee will continue to consider compensation risk implications while
deliberating the design of our executive compensation programs. In its discussions, the Compensation Committee considered the attributes
of our programs, including:



| | • | Appropriate pay philosophy in light of our business model;
| | - | ----------------------------------------------------------



| | • | Balance with respect to the mix of cash and equity compensation, and measures of performance against
both annual and multi-year standards;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------



-18-







| | • | Short and long-term incentives linked to stock price performance;
| | - | -----------------------------------------------------------------



| | • | Performance goals are set at levels that are sufficiently high to encourage strong performance
and support the resulting compensation expense, but within reasonably attainable parameters to discourage pursuit of excessively
risky business strategies;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | Long-term incentives generally have multi-year vesting to ensure a long-term focus and appropriate
balance against short-term goals;
| | - | ------------------------------------------------------------------------------------------------------------------------------------



| | • | Independent Compensation Committee oversight, with Compensation Committee discretion to reduce
incentives based on subjective evaluation of individual performance; and
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | Anti hedging/pledging policies.
| | - | -------------------------------



Equity
Compensation Plan Information



The table below presents information as of December 31, 2017,
with respect to our ordinary shares issuable under our equity compensation plans:



|Plan category                                              |  | Number of securities to be issued upon exercise of outstanding options, warrants and rights |           |     | Weighted-average exercise price of outstanding options, warrants and rights |  |       | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) | 
|---------------------------------------------------------- |  | ------------------------------------------------------------------------------------------- | --------- | --- | --------------------------------------------------------------------------- |  | ----- | ------------------------------------------------------------------------------------------------------------------------------------------- | 
|                                                           |  | (a)                                                                                         |           |     | (b)                                                                         |  |       | (c)                                                                                                                                         | 
|Equity compensation plans approved by security holders     |  |                                                                                             | 6,754,000 | (1) |                                                                             |  | 12.16 | (2)                                                                                                                                         | 
|Equity compensation plans not approved by security holders |  |                                                                                             | 0         |     |                                                                             |  | 0     |                                                                                                                                             | 
|Total                                                      |  |                                                                                             | 6,754,000 | (1) |                                                                             |  | 12.16 | (2)                                                                                                                                         | 



| | (1) | Includes 819,000 ordinary shares that have previously
been granted as free share awards but are pending issuance upon vesting date; the beneficiary is not required to pay any exercise
price upon issuance of such 819,000 shares. The remaining 5,935,000 ordinary shares are issuable pursuant to the exercise of outstanding
options and warrants upon payment of the weighted-average exercise price shown in column (b) of this table.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | The weighted-average exercise price shown in column (b)
applies to 5,935,000 ordinary shares issuable pursuant to the exercise of outstanding options and warrants included in the total
number shown in column (a) of this table. As to the 819,000 shares attributable to free share awards included in the total number
shown in column (a) of this table, the beneficiary is not required to pay any exercise price upon issuance of such shares.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Represents the aggregate number of shares issuable pursuant
to stock options, free share awards or non-employee director warrants that have not been granted under the authorizations approved
by shareholders at our 2017 Annual General Meeting of Shareholders.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



2017 Omnibus Incentive Compensation
Plan



The following description
of the 2017 Omnibus Incentive Compensation Plan (the “2017 Omnibus Plan”) is a summary, does not purport to be a complete
description of the 2017 Omnibus Plan and is qualified in its entirety by the full text of the 2017 Omnibus Plan, the complete text
of which was set forth as Annex A to the Company's Definitive Proxy Statement on Schedule 14A filed with the Securities and Exchange
Commission on May 1, 2017.



General



The 2017 Omnibus Plan
covers the grant of awards to Avadel’s employees (including officers), non-employee consultants and non-employee directors
and those of Avadel’s affiliates, except that incentive stock options may only be granted to employees (including officers)
of the Company and its subsidiaries. Under the terms of the 2017 Omnibus Plan, an aggregate of 4,000,000 ordinary shares, par value
$0.01 per share, will be authorized for delivery in settlement of awards (including incentive stock options).



-19-







We expect that the
Compensation Committee of the Board of Directors (the “Committee”) will administer the 2017 Omnibus Plan. The Committee
may delegate any or all of its administrative authority to our Chief Executive Officer or to a Management Committee except with
respect to awards to executive officers who are subject to Section 16 of the Exchange Act or are covered employees subject to the
deduction limits under Section 162(m) of the Internal Revenue Code of 1986, as amended (the “Code”). In addition, the
full Board of Directors must serve as the Committee with respect to any awards to our non-employee directors, and non-employee
directors may not be granted awards that taken together with any cash fees paid to such non-employee director during any calendar
year exceeds $675,000 (calculating the value of the award for financial accounting purposes) (up to twice that limit for a non-executive
chair of the Board of Directors or, in extraordinary circumstances, for other non-employee directors).



The ordinary shares
delivered to settle awards made under the 2017 Omnibus Plan may be authorized and unissued shares or treasury shares. If any shares
subject to any award granted under the 2017 Omnibus Plan (other than a substitute award) is forfeited or otherwise terminated without
delivery of such shares, the shares subject to such awards will again be available for issuance under the 2017 Omnibus Plan. However,
any shares that are withheld or applied as payment for shares issued upon exercise of an award or for the withholding or payment
of taxes due upon exercise of the award will continue to be treated as having been delivered under the 2017 Omnibus Plan and will
not again be available for grant under the 2017 Omnibus Plan. Also, upon settlement of a stock appreciation right, the number of
shares underlying the portion of the stock appreciation right that is exercised shall be treated as having been delivered under
the 2017 Omnibus Plan and will not again be available for grant under the 2017 Omnibus Plan.



If a dividend or other
distribution (whether in cash, ordinary shares or other property), recapitalization, forward or reverse stock split, subdivision,
consolidation or reduction of capital, reorganization, merger, consolidation, scheme of arrangement, split-up, spin-off or combination
involving us or repurchase or exchange of our shares or other securities, or other rights to purchase shares of our securities
or other similar transaction or event affects our ordinary shares such that the Committee determines that an adjustment is appropriate
in order to prevent dilution or enlargement of the benefits (or potential benefits) provided to grantees under the 2017 Omnibus
Plan, the Committee will make an equitable change or adjustment as it deems appropriate in the number and kind of securities subject
to awards (whether or not then outstanding) and the related exercise price relating to an award.



The maximum number
of ordinary shares that are subject to awards granted to any individual in a single calendar year may not exceed 1,500,000 shares
(twice that limit for awards that are granted to an eligible person in the calendar year in which the eligible person first commences
employment or service) (based on the highest level of performance resulting in the maximum payout). In addition, the maximum value
of all awards to be settled in cash or property other than our ordinary shares that may be granted to any individual in a single
calendar year may not exceed $5,000,000 million (twice that limit for awards that are granted to an eligible person in the calendar
year in which the eligible person first commences employment or service) (based on the highest level of performance resulting in
the maximum payout). These limitations apply to the calendar year in which the awards are granted and not the year in which such
awards settle. Such annual limitations apply to dividend equivalents only if such dividend equivalents are granted separately from
and not as a feature of another award.



Types of Awards



The 2017 Omnibus Plan
permits the granting of any or all of the following types of awards to all grantees:



| | • | ​stock options, including incentive stock options, or
ISOs;
| | - | -----------------------------------------------------------



| | • | stock appreciation rights, or SARs;
| | - | -----------------------------------



| | • | restricted stock;
| | - | -----------------



| | • | deferred stock and restricted stock units;
| | - | ------------------------------------------



| | • | performance units and performance shares;
| | - | -----------------------------------------



| | • | dividend equivalents;
| | - | ---------------------



| | • | bonus shares;
| | - | -------------



| | • | other stock-based awards; and
| | - | -----------------------------



| | • | cash incentive awards.
| | - | ----------------------



Generally, awards under
the 2017 Omnibus Plan are granted for no consideration other than prior and future services, provided that the nominal value of
any newly issued shares the subject of such grant is fully paid. Awards granted under the 2017 Omnibus Plan may, in the discretion
of the Committee, be granted alone or in addition to, in tandem with or in substitution for, any other award under the 2017 Omnibus
Plan or other plan of ours; provided, however, that if an SAR is granted in tandem with an ISO, the SAR and ISO must have the same
grant date and term and the exercise price of the SAR may not be less than the exercise price of the ISO. The material terms of
each award will be set forth in a written award agreement between the grantee and us.



-20-







Vesting conditions
for any award (other than awards excluded from the minimum vesting requirement as set forth herein) that relate exclusively to
the passage of time and continued employment or other service shall not be less than 36 months, with no more than thirty-three
and one-third percent (33-1/3%) of the award vesting every 12 months from the date of the award, with no such award or any portion
thereof eligible to vest earlier than 12 months from the date of grant of the Award. If the vesting condition for any award relates
to the attainment of specified performance goals, such award shall vest over a performance period of not less than one (1) year.
Notwithstanding the foregoing, awards that result in the issuance of an aggregate of up to 5% of the ordinary shares available
under the 2017 Omnibus Plan may be granted without regard to such minimum vesting requirements.



Stock Options and SARs



The Committee is authorized
to grant SARs and stock options (including ISOs except that an ISO may only be granted to an employee of ours or one of our subsidiary
corporations). A stock option allows a grantee to purchase a specified number of our ordinary shares at a predetermined price per
share (the “exercise price”) during a fixed period measured from the date of grant. An SAR entitles the grantee to
receive the excess of the fair market value of a specified number of shares on the date of exercise over a predetermined exercise
price per share. The exercise price of an option or an SAR will be determined by the Committee and set forth in the award agreement
but the exercise price may not be less than the fair market value of an ordinary share on the grant date (110 percent of the fair
market value in case of certain incentive stock options). The term of each option or SAR is determined by the Committee and set
forth in the award agreement, except that the term may not exceed 10 years (5 years in case of certain incentive stock options).
Options may be exercised by payment of the purchase price through one or more of the following means: payment in cash (including
personal check or wire transfer), or, with the approval of the Committee, by delivering ordinary shares previously owned by the
grantee, by delivery of ordinary shares acquired upon the exercise of such option or by delivering restricted shares. The Committee
may also permit a grantee to pay the exercise price of an option through the sale of shares acquired upon exercise of the option
through a broker-dealer to whom the grantee has delivered irrevocable instructions to deliver sales proceeds sufficient to pay
the purchase price to us.



Restricted Shares



The Committee may award
restricted shares consisting of ordinary shares which remain subject to a risk of forfeiture and may not be disposed of by grantees
until certain restrictions established by the Committee lapse. The vesting conditions may be service-based (i.e., requiring continuous
service for a specified period) or performance-based (i.e., requiring achievement of certain specified performance objectives)
or both. A grantee receiving restricted shares will have all of the rights of a shareholder, including the right to vote the shares
and the right to receive any dividends (generally subject to reinvestment into additional restricted shares), except as otherwise
provided in the award agreement. Upon termination of the grantee’s affiliation with us during the restriction period (or,
if applicable, upon the failure to satisfy the specified performance objectives during the restriction period), the restricted
shares will be forfeited as provided in the award agreement.



Restricted Stock Units and Deferred
Stock



The Committee may also
grant restricted stock unit awards and/or deferred stock awards. A deferred stock award is the grant of a right to receive a specified
number of our ordinary shares at the end of specified deferral periods or upon the occurrence of a specified event, which satisfies
the requirements of Section 409A of the Internal Revenue Code. A restricted stock unit award is the grant of a right to receive
a specified number of our ordinary shares (or the cash value thereof) upon lapse of a specified forfeiture condition (such as completion
of a specified period of service or achievement of certain specified performance objectives). If the service condition and/or specified
performance objectives are not satisfied during the restriction period, the award will lapse without the issuance of the shares
underlying such award (or the cash value thereof).



Restricted stock units
and deferred stock awards carry no voting or other rights associated with stock ownership. The award agreement will provide whether
grantees may receive dividend equivalents with respect to restricted stock units or deferred stock, and if so, whether such dividend
equivalents are distributed when credited or deemed to be reinvested in additional shares of restricted stock units or deferred
stock.



Performance Units



The Committee may grant
performance units, which entitle a grantee to cash or shares conditioned upon the fulfillment of certain performance conditions
and other restrictions as specified by the Committee and reflected in the award agreement. The initial value of a performance unit
will be determined by the Committee at the time of grant. The Committee will determine the terms and conditions of such awards,
including performance and other restrictions placed on these awards, which will be reflected in the award agreement.



-21-







Performance Shares



The Committee may grant
performance shares, which entitle a grantee to a certain number of ordinary shares, conditioned upon the fulfillment of certain
performance conditions and other restrictions as specified by the Committee and reflected in the award agreement. The Committee
will determine the terms and conditions of such awards, including performance and other restrictions placed on these awards, which
will be reflected in the award agreement.



Bonus Shares



The Committee may grant
fully vested ordinary shares as bonus shares or ordinary shares subject to such terms and conditions as are specified in the award
agreement.



Dividend Equivalents



The Committee is authorized
to grant dividend equivalents which provide a grantee the right to receive payment equal to the dividends paid on a specified number
of our ordinary shares. Dividend equivalents may be paid directly to grantees or may be deferred for later delivery under the 2017
Omnibus Plan. If deferred such dividend equivalents may be credited with interest or may be deemed to be invested in our ordinary
shares or in other property. No dividend equivalents may be granted in conjunction with any grant of stock options or SARs.



Cash Incentive Awards



The Committee may grant
cash incentive awards to any eligible person in such amounts and upon such terms, including the achievement of specific performance
goals during the applicable performance period, as the Committee may determine. An eligible person may have more than one cash
incentive award outstanding at any time. For instance, the Committee may grant an eligible employee one cash incentive award with
a calendar year performance period as an annual incentive bonus and a separate cash incentive award with a multi-year performance
period as a long-term cash incentive bonus.



The Committee shall
establish performance goals applicable to each cash incentive award in its discretion and the amount that will be paid to the grantee
pursuant to such cash incentive award if the applicable performance goals for the performance period are met. If an eligible person
earns the right to receive a payment with respect to a cash incentive award, such payment will be made in cash in accordance with
the terms of the award agreement. If the award agreement does not specify a payment date with respect to a cash incentive award,
payment of the cash incentive award will be made no later than the 15th day of the third month following the end of the taxable
year of the grantee or our fiscal year during which the performance period ends.



Other Stock-Based Awards



In order to enable
us to respond to material developments in the area of taxes and other legislation and regulations and interpretations thereof,
and to trends in executive compensation practices, the 2017 Omnibus Plan authorizes the Committee to grant awards that are valued
in whole or in part by reference to or otherwise based on our securities. The Committee determines the terms and conditions of
such awards, including consideration paid for awards granted as share purchase rights and whether awards are paid in shares or
cash.



Performance-Based Awards



The Committee may require
satisfaction of pre-established performance goals, consisting of one or more business criteria and a targeted performance level
with respect to such criteria, as a condition of awards being granted or becoming exercisable or payable under the 2017 Omnibus
Plan, or as a condition to accelerating the timing of such events. The Committee has the discretion to adjust the determinations
of the degree of attainment of the pre-established performance goals.



The 2017 Omnibus Plan
permits the grant of awards that are intended to constitute qualified performance-based compensation that is exempt from the $1
million deduction limit under Section 162(m) of the Code. Those types of awards may be based on the following performance criteria:
the attainment by an ordinary share of a specified fair market value for a specified period of time or within a specified period
of time; earnings per share; earnings per share from continuing operations; total shareholder return; return on assets; return
on equity; return on capital; earnings before or after taxes, interest, depreciation, and/or amortization; return on investment;
interest expense; cash flow; cash flow from operations; revenues; sales; costs; assets; debt; expenses; inventory turnover; economic
value added; cost of capital; operating margin; gross margin; net income before or after taxes; operating earnings either before
or after interest expense and either before or after incentives or asset impairments; attainment of cost reduction goals; revenue
per customer; customer turnover rate; asset impairments; financing costs; capital expenditures; working capital; strategic business
criteria, consisting of one or more objectives based on meeting specified revenue, market penetration, geographic business expansion
goals, objectively identified project milestones, production volume levels, cost targets, and goals relating to acquisitions or
divestitures; customer satisfaction, aggregate product price and other product price measures; safety record; service reliability;
debt rating; and achievement of business and operational goals, such as market share, new products, and/or business development.
The Committee will certify in writing if the applicable performance conditions are achieved before payment of the award. For awards
intended to comply with the performance-based exception under Section 162(m) of the Code, the Committee shall set the performance
measures within the time period prescribed by Section 162(m) of the Code and no later than 90 days after the commencement of the
period of service to which the awards intended to comply with the performance-based exception relate (but in no event after 25
percent of the period of service has elapsed).



-22-







Awards generally may
be settled in cash, ordinary shares, other awards or other property, in the discretion of the Committee.



Change of Control



If there is a merger
or consolidation of us with or into another corporation or a sale of substantially all of our ordinary shares (a “Corporate
Transaction”) that results in a change in control (as defined in the 2017 Omnibus Plan), and the outstanding awards are not
assumed by surviving company (or its parent company) or replaced with economically equivalent awards granted by the surviving company
(or its parent company), the Committee will cancel any outstanding awards that are not vested and nonforfeitable as of the consummation
of such Corporate Transaction (unless the Committee accelerates the vesting of any such awards) and with respect to any vested
and nonforfeitable awards, the Committee may either (i) allow all grantees to exercise options and SARs within a reasonable period
prior to the consummation of the Corporate Transaction and cancel any outstanding options or SARs that remain unexercised upon
consummation of the Corporate Transaction, or (ii) cancel any or all of such outstanding awards (including options and SARs) in
exchange for a payment (in cash, or in securities or other property) in an amount equal to the amount that the grantee would have
received (net of the exercise price with respect to any options or SARs) if the vested awards were settled or distributed or such
vested options and SARs were exercised immediately prior to the consummation of the Corporate Transaction. If an exercise price
of the option or SAR exceeds the fair market value of our ordinary shares and the option or SAR is not assumed or replaced by the
surviving company (or its parent company), such options and SARs will be cancelled without any payment to the grantee. If any other
award is not vested immediately prior to the consummation of the Corporate Transaction, such award will be cancelled without any
payment to the grantee.



Amendment to and Termination of the 2017 Omnibus Plan



The 2017 Omnibus Plan
may be amended, altered, suspended, discontinued or terminated by our Board of Directors without further shareholder approval,
unless such approval of an amendment or alteration is required by law or regulation or under the rules of any stock exchange or
automated quotation system on which the ordinary shares are then listed or quoted. Thus, shareholder approval will not necessarily
be required for amendments which might increase the cost of the 2017 Omnibus Plan. Shareholder approval will not be deemed to be
required under laws or regulations that condition favorable treatment of grantees on such approval, although our Board of Directors
may, in its discretion, seek shareholder approval in any circumstance in which it deems such approval advisable.



In addition, subject
to the terms of the 2017 Omnibus Plan, no amendment or termination of the 2017 Omnibus Plan may materially and adversely affect
the right of a grantee under any outstanding award granted under the 2017 Omnibus Plan.



Unless earlier terminated
by our Board of Directors, the 2017 Omnibus Plan will terminate when no ordinary shares remain reserved and available for issuance
or, if earlier, on the tenth anniversary after the adoption of the 2017 Omnibus Plan by our Board of Directors.



No Repricing



Notwithstanding any other provision of the
2017 Omnibus Plan, no Option or SAR may be amended to reduce the exercise or grant price nor cancelled in exchange for other Options
or SARs with a lower exercise or grant price or ordinary shares or cash, without shareholder approval.



Miscellaneous



Each Participant in
the 2017 Omnibus Plan may be bound by and subject to non-competition, confidentially and invention ownership agreements. They also
remain subject to the trading window policies adopted by the Company from time to time with respect to the exercise of Options,
Stock Appreciation Rights or the sale of shares of Company Stock acquired pursuant to the 2017 Omnibus Plan. A grantee shall forfeit
any and all rights under an Award upon notice of termination by the Company for “Cause”, as such term is defined in
the 2017 Omnibus Plan or an employment agreement, if applicable. Award agreements shall contain such other terms and conditions
as the Committee may determine in its sole discretion (to the extent not inconsistent with the 2017 Omnibus Plan).



-23-







U.S. Federal Income Tax Consequences



The grant of an option
or SAR will create no tax consequences for the participant or us at the time of the grant. A participant will have no taxable income
upon exercise of an incentive stock option except that a participant must recognize income equal to the fair market value of the
ordinary shares acquired minus the exercise price for alternative minimum tax purposes. Upon exercise of an option (other than
an incentive stock option) or a SAR, a participant generally must recognize ordinary income equal to the fair market value of the
ordinary shares acquired minus the exercise or grant price. Upon a disposition of shares acquired by exercise of an incentive stock
option on or before the earlier of the second anniversary of the grant of such incentive stock option or the first anniversary
of the exercise of such option, the participant generally must recognize ordinary income equal to the lesser of
(1) the fair market value of the shares at the date of exercise minus the exercise price or (2) the amount realized upon the disposition
of the incentive stock option shares minus the exercise price. Otherwise, a participant’s disposition of shares acquired
upon the exercise of an option (including an incentive stock option for which the incentive stock option holding periods are met)
generally will result in only capital gain or loss. Other awards under the 2017 Omnibus Plan, including restricted stock and restricted
stock units will generally result in ordinary income to the participant equal to the cash or the fair market value of the ordinary
shares or other property (minus the amount, if any, paid by the participant for shares or other property) at the time such cash,
ordinary shares or other property is received by the participant or the time that the substantial risk of forfeiture of such ordinary
shares or other property lapses.



We are generally entitled
to claim a tax deduction with respect to an award granted under the Plan when the participant recognizes ordinary income with respect
to the award in an amount equal to the ordinary income that is recognized by the participant. We are not entitled to claim any
tax deduction for any amount recognized by a participant as capital gains.



We are permitted to
withhold from any award granted under the 2017 Omnibus Plan any required withholding taxes. Payment of withholding taxes may be
made through one or more of the following means: payment in cash (including personal check or wire transfer), or, with the approval
of the Committee, by delivering ordinary shares previously owned by the grantee or by delivery of ordinary shares acquired or to
be acquired under the award.



Section 83(b) of the Code



A participant may elect
under Section 83(b) of the Code to be taxed at the time of grant of restricted stock or other restricted property on the fair market
value of the ordinary shares or other property at that time rather than to be taxed when the risk of forfeiture lapses on the value
of the property at that time, and we would have a deduction available at the same time and in the same amount as the participant
recognizes income. If a participant files an election under Section 83(b) of the Code and the participant subsequently forfeits
the restricted shares or other restricted property, he or she would not be entitled to any tax deduction, including as a capital
loss, for the value of the ordinary shares or property on which he or she previously paid tax. Except as discussed below, we generally
will be entitled to a tax deduction at the time and equal to the amount recognized as ordinary income by the participant in connection
with an option, stock appreciation right, or other award, but will be entitled to no tax deduction relating to amounts that represent
a capital gain to a participant. Thus, we will not be entitled to any tax deduction with respect to an incentive stock option if
the participant holds the shares for the incentive stock option holding periods.



Section 162(m) of the Code



Section 162(m) of the
Code limits the amount of compensation we may deduct with respect to our Chief Executive Officer and each of the other three highest
paid named executive officers (other than a chief financial officer) to $1 million per year. This deduction limit generally applies
to companies that have any class of equity securities that is publicly held. This limitation does not apply, however, to performance-based
compensation that satisfies certain requirements, including approval of the material terms of the plan by the company’s shareholders.



Section 409A of the Code



Some restricted stock
units and other awards subject to deferral features may be subject to Section 409A of the Code, which regulates deferred compensation
arrangements. In such cases, the timing of the settlement of the award would have to meet certain restrictions in order for the
participant not to be subject to accelerated tax and a tax penalty at the time of vesting rather than at the time of settlement.
One significant restriction would be a requirement that the timing of the settlement not be controlled by the participant’s
exercise of discretion. If the participant is subject to accelerated tax at the time of vesting (instead of the time of settlement),
our deduction would also be accelerated. If we grant awards under the 2017 Omnibus Plan that constitute deferred compensation within
the meaning of Section 409A of the Code, such awards will generally be structured to comply with the applicable requirements imposed
under Section 409A.



-24-







2017 Employee Stock Purchase Plan



The principal features
of the Avadel Pharmaceuticals plc 2017 Avadel Employee Share Purchase Plan (hereafter, the “2017 ESPP”) are summarized
below. The summary is qualified in its entirety by reference to the full text of the 2017 ESPP, a copy of which was set forth as
Annex B to the Company's Definitive Proxy Statement on Schedule 14A filed with the Securities and Exchange Commission on May 1,
2017. Definitions in this summary of the 2017 ESPP are applicable only within this section.



The Company believes
that the 2017 ESPP is appropriate and will offer employees an opportunity to purchase ordinary shares or ADSs directly from us
at a discounted price which will help further align their interests with those of our shareholders. The 2017 ESPP will broaden
employee access to our ordinary shares or ADSs by offering employees the opportunity to purchase such securities through convenient
payroll deductions.



Administration



The ESPP will be administered
by the Compensation Committee of the Board (the “Committee”), which may delegate its duties and powers in whole or
in part as it determines appropriate. The Committee is authorized to interpret the ESPP, to establish, amend and rescind any rules
and regulations relating to it and to make any other determinations that it deems necessary or desirable for the administration
of the ESPP.



Eligibility; Election to Participate



Any individual who
is an employee of the Company or of a subsidiary of the Company that is selected to participate in the ESPP by the Committee in
its sole discretion is eligible to participate in the ESPP, unless such employee is specifically excluded from participation by
the Committee (either individually or by reference to a group or category of employees). Without limiting the generality of the
foregoing, the Committee may exclude from participation:



| | • | employees whose customary employment is 20 hours or less per week within the meaning of section 423(b)(4)(B) of the Code;
| | - | -------------------------------------------------------------------------------------------------------------------------



| | • | employees whose customary employment is for not more than 5 months in any calendar year within the meaning of section 423(b)(4)(C)
of the Code;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------



| | • | employees who have been employed less than two (2) years within the meaning of Section 423(b)(4)(A) of the Code; and
| | - | --------------------------------------------------------------------------------------------------------------------



| | • | employees who are highly compensated employees within the meaning of section 414(q) of the Code.
| | - | ------------------------------------------------------------------------------------------------



The Committee will
set forth procedures pursuant to which eligible employees may elect to participate in a given offering period under the ESPP (which
may be on different terms for different eligible employees or subgroups thereof). An “offering period” is a period
of time established by the Committee from time to time not to exceed 27 months.



As of April 27, 2018,
approximately 150 employees would be eligible to participate in the ESPP.



Shares Subject to the ESPP



The total number of
Company ordinary shares, nominal value $0.01 per share, or ADSs representing such ordinary shares (collectively, “Shares”)
which may be issued under the ESPP is 1,000,000. The Shares may consist, in whole or in part, of unissued Shares or previously
issued Shares. The Committee shall determine whether any participation under the ESPP shall be with respect to ordinary shares
or ADSs.



Grant of Option on Enrollment; Purchase
Price



With respect to an
offering period, each eligible employee who elects to participate in the ESPP (a “participant”) will be granted an
option to subscribe for or purchase, as of the last date of the offering period (the “purchase date”), a number of
Shares equal to the lesser of:



| | • | the maximum number of Shares that a participant may purchase on any given purchase date (as determined by the Committee, which,
in the absence of any contrary determination, shall be 3,000 Shares); or
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | the number determined by dividing the amount accumulated in an account to which payroll deductions of a participant, or other
payments made by a participant to the extent provided by the Committee, are credited (the “payroll deduction account”)
during an offering period by the purchase price per Share (the “purchase price”).
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



-25-







The purchase price
at which a Share will be issued or sold for a given offering period will be established by the Committee (and may differ among
participants, as determined by the Committee in its sole discretion) but will in no event be less than 85% of the lesser of:



| | • | the fair market value of a Share on the offering date; or
| | - | ---------------------------------------------------------



| | • | the fair market value of a Share on the purchase date.
| | - | ------------------------------------------------------



Notwithstanding the
foregoing, no eligible employee may be granted an option to purchase Shares under the ESPP if, immediately after the grant of the
option, such employee (and/or any other person whose Shares would be attributed to the employee) would immediately thereafter be
deemed to own Shares possessing 5% or more of the total combined voting power or value of all classes of shares of the Company
or any parent or subsidiary corporation within the meaning of section 423(b)(3) of the Code. For this purpose, the rules of section
424(d) of the Code will apply in determining Share ownership of an individual, and Shares which the employee may purchase under
outstanding options will be treated as Shares owned by the employee. All eligible employees granted options under the ESPP shall
have the same rights and privileges as required by Section 423(b)(5) of the Code.



In addition, no eligible
employee may be granted an option to purchase Shares under the ESPP which permits the employee to purchase Shares under the ESPP
and all similar plans of the Company or any parent or subsidiary at a rate which exceeds $25,000 of the fair market value of Shares
(determined at the grant date of the option) for any calendar year in which the option is outstanding.



Payment of Purchase Price; Changes in
Payroll Deductions; Issuance of Shares



Payroll deductions
(to the extent permitted by applicable local law) will be made on each day that a participant is paid during an offering period.
The deductions will be made at the participant’s election as a percentage of the participant’s compensation in 1% increments,
from 1% up to such maximum percentage of the participant’s compensation (or maximum dollar amount) as is permitted by the
Committee from time to time with respect to that offering period. The maximum percentage or dollar amount may differ among certain
participants. In the absence of any contrary determination by the Committee, the maximum percentage of the participant’s
compensation that may be contributed to the payroll deduction account for an offering period shall be fifteen percent (15%). For
a given offering period, payroll deductions will commence on the offering date and will end on the related purchase date, unless
sooner altered or terminated as provided in the ESPP. A participant’s “compensation” will be defined from time
to time by the Committee in its sole discretion with respect to any option or offering period and may be defined differently for
different participants for purposes of the ESPP. Except as otherwise defined by the Committee, “compensation” will
(1) include a participant’s base salary or wages, in each case prior to reductions for pre-tax contributions made to a plan
or salary reduction contributions to a plan excludable from income under sections 125 or 402(g) of the Code, and (2) exclude commissions,
overtime, shift pay, severance pay, bonuses, retirement income, change in control payments, contingent payments, income derived
from share options, share appreciation rights and other equity-based compensation and other forms of special remuneration.



Unless otherwise determined
by the Committee, a participant may not change the rate of payroll deductions once an offering period has commenced. The Committee
will specify procedures by which a participant may increase or decrease the rate of payroll deductions for subsequent offering
periods.



All payroll deductions
made with respect to a participant will be credited to the participant’s payroll deduction account and will be deposited
with the general funds of the Company. To the extent permitted by applicable local law, no interest will accrue on the amounts
credited to that payroll deduction account. All payroll deductions received or held by the Company may be used by it for any corporate
purpose, and the Company will not be obligated to segregate these payroll deductions, to the extent permitted by applicable local
law. Except to the extent provided by the Committee, a participant may not make any separate cash payments into the participant’s
payroll deduction account, and payment for Shares purchased under the ESPP may not be made in any form other than by payroll deduction.



On each purchase date,
the Company will apply all funds then in the participant’s payroll deduction account to purchase Shares pursuant to the option
granted on the offering date for that offering period. In the event that the number of Shares to be purchased by all participants
in any offering period exceeds the number of Shares then available for issuance under the ESPP, the Company will make a pro rata
allocation of the remaining Shares in as uniform a manner as practicable and as the Committee, in its sole discretion, determines
to be equitable, and all funds not used to purchase Shares on the purchase date will be returned, without interest (to the extent
permitted by applicable local law), to the participants.



As soon as practicable
following the end of each offering period, the number of Shares purchased by each participant will be deposited into an account
established in the participant’s name. Unless otherwise permitted by the Committee in its sole discretion, dividends (if
any) that may be declared on the Shares held in that account will be reinvested in whole or fractional Shares.



-26-







Withdrawal; Termination of Employment



Each participant may
withdraw from participation in respect of an offering period under terms and conditions established by the Committee in its sole
discretion. Upon a participant’s withdrawal from participation in respect of any offering period, all accumulated payroll
deductions in the participant’s payroll deduction account will be returned, without interest (to the extent permitted by
applicable local law), to that participant, and that participant will not be entitled to purchase any Shares on the purchase date
or thereafter with respect to the offering period in effect at the time of withdrawal. The participant will be permitted to participate
in subsequent offering periods pursuant to terms and conditions established by the Committee in its sole discretion. A participant
will be deemed to have withdrawn from the ESPP as of the date of any hardship withdrawal from any cash or deferred arrangement
within the meaning of Section 401(k) of the Code.



A participant will
cease to participate in the ESPP upon the participant’s termination of employment from the Company or any participating subsidiary
for any reason. All payroll deductions credited to the former participant’s payroll deduction account as of the date of termination
will be:



| | • | in the event termination is due to a transfer to a non-participating subsidiary of the Company, applied to the purchase of
Shares on the next purchase date; or
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | in the event termination is due to any other reason, returned, without interest (to the extent permitted by applicable local
law), to the former participant or to the former participant’s designated beneficiary, as the case may be, and the former
participant or beneficiary will have no future rights in any unexercised options under the ESPP, unless the participant again becomes
an eligible employee.
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The Committee will
determine the extent to which any leave of absence will impact the participant’s participation in the ESPP.



Adjustments Upon Certain Events



Generally. In
the event of any change in the outstanding Shares by reason of any Share dividend or split, reorganization, recapitalization, merger,
consolidation, amalgamation, spin-off or combination transaction or repurchase or exchange of Shares or other corporate exchange,
or any distribution to shareholders of Shares other than regular cash dividends or any transaction similar to the foregoing, the
Committee in its sole discretion and without liability to any person will make such substitution or adjustment, if any, as it deems
to be equitable, as to:



| | • | the number or kind of shares or other securities or property issued or reserved for issuance pursuant to the ESPP;
| | - | ------------------------------------------------------------------------------------------------------------------



| | • | the number or kind of shares or other securities subject to outstanding options;
| | - | --------------------------------------------------------------------------------



| | • | the purchase price; and/or
| | - | --------------------------



| | • | any other affected terms of these options.
| | - | ------------------------------------------



Change in Control.
In the event of a change in control (as defined in the ESPP), the Committee in its sole discretion and without liability to any
person may terminate the then current offering period and take other actions, if any, as it deems necessary or desirable with respect
to any option as of the date of the consummation of the change in control. For purposes of the ESPP, a “change of control”
would be deemed to occur upon any of the same events that constitute a “change of control” under the Company’s
2017 Omnibus Incentive Compensation Plan described in this Form 10-K/A.



Restrictions on Transfer



Options granted under
the ESPP will not be transferable or assignable by the participant other than by will or by the laws of descent and distribution.



Amendment or Termination



The ESPP will continue
until the earliest to occur of the following:



| | • | termination of the ESPP by the Board;
| | - | -------------------------------------



| | • | issuance of all of the Shares reserved for issuance under the ESPP; or
| | - | ----------------------------------------------------------------------



| | • | June 27, 2027.
| | - | --------------



-27-







The Board may amend,
alter or discontinue the ESPP, but no amendment, alteration or discontinuation will be made which:



| | • | without the approval of the shareholders of the Company, would increase the total number of Shares reserved for the purposes
of the ESPP; or
| | - | --------------------------------------------------------------------------------------------------------------------------------------------



| | • | without the consent of a participant, would materially adversely affect the rights of a participant under any option granted
to the participant under the ESPP.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



The Committee may amend
the ESPP, however, in such manner and terminate any offering period (in whole or in part) as it deems necessary to permit the granting
of options to meet the requirements of the Code or other applicable laws.



New Plan Benefits



All awards to eligible
employees under the ESPP are made at the discretion of the Committee and its delegates. Therefore, the benefits and amounts that
will be received or allocated under the plan are not determinable at this time. Please refer to the description of grants made
to named executive officers in the last fiscal year described in the “Grants of Plan-Based Awards for Fiscal 2016”
table.



Tax Withholding



The Company has the
right to withhold from a participant such withholding taxes as may be required by federal, state, local or other law, or to otherwise
require the participant to pay such withholding taxes. Unless the Committee specifies otherwise, a participant may elect to pay
a portion or all of such withholding taxes by:



| | • | delivery of Shares, provided that such Shares have been held by the participant for no less than 6 months (or such other period
as established from time to time by the Committee if required to avoid adverse accounting under any generally accepted accounting
principles); or
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | having Shares equal to the minimum statutory withholding rate withheld by the Company from any Shares that otherwise would
have been received by the participant (or such other amount as is permitted without adverse accounting).
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Choice of Law



The ESPP shall be governed
by the laws of the State of Delaware.



Federal Income Tax Information



The following summary
briefly describes U.S. federal income tax consequences of rights under the ESPP. The summary, however, is not a detailed or complete
description of all U.S. federal tax laws or regulations that may apply and does not address any local, state or other country laws.
Therefore, no one should rely on this summary for individual tax compliance, planning or decisions. Participants in the ESPP should
consult their own professional tax advisors concerning tax aspects of rights under the ESPP.



Generally



For eligible employees
of U.S. subsidiaries, the ESPP is intended to be an “employee stock purchase plan” within the meaning of Section 423
of the Code. All payroll deductions elected by a participant under the Plan are made on an after-tax basis. No taxable income will
be recognized by a participant, and no deductions will be allowable to the Company, upon either the grant or the exercise of the
option granted under the ESPP. Taxable income will not be recognized until there is a sale or other disposition of the Shares acquired
under the ESPP or in the event the participant should die while still owning the purchased Shares.



If the participant
sells or otherwise disposes of the purchased Shares within two years after the first day of the relevant purchase period or one
year after the purchase date, the participant will recognize ordinary income in the year of sale or disposition equal to the amount
by which the fair market value of the Shares on the purchase date exceeded the purchase price of those Shares. If the participant
sells or otherwise disposes of the purchased Shares more than two years after the first day of the relevant purchase period and
more than one year after the purchase date, then the participant will recognize ordinary income in the year of sale or disposition
equal to the lesser of (i) the amount by which the fair market value of the Shares on the sale or disposition date exceeded the
purchase price paid for those Shares or (ii) 15% of the fair market value of the Shares on the first day of the purchase period.
Any additional gain upon the disposition will be taxed as a long-term capital gain.



-28-







If the participant
owns Shares acquired under Plan at the time of death, the lesser of (i) the amount by which the fair market value of the Shares
on the date of death exceeds the purchase price or (ii) 15% of the fair market value of the Shares on the first day of the purchase
period will constitute ordinary income in the year of death.



If the purchased Shares
are sold or otherwise disposed of within two years after the first day of the relevant purchase period or one year after the purchase
date, the Company will be entitled to a tax deduction in the year of such sale or disposition equal to the amount of ordinary income
recognized by the participant as a result of such sale or disposition. In all other cases, no deduction will be allowed.



Code Section 409A



Section 409A of the
Code generally provides rules that must be followed with respect to covered deferred compensation arrangements in order to avoid
the imposition of an additional 20% tax (plus interest) upon the service provider who is entitled to receive the deferred compensation.
Purchase rights that may be granted under the ESPP should not constitute “deferred compensation” within the meaning
of and subject to section 409A. While the Committee intends to administer and operate the ESPP in a manner that will avoid the
imposition of additional taxation under section 409A upon a participant, the Company cannot provide any assurance that additional
taxation under section 409A will be avoided in all cases. In the event the Company is required to delay delivery of Shares or any
other payment under the ESPP in order to avoid the imposition of an additional tax under section 409A, the Company will deliver
such Shares (or make such payment) on the first day that would not result in the participant incurring any tax liability under
section 409A.



Pay Ratio Disclosure



Under
Section 953(b) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(u) of Regulation S-K, the Company
is required to provide the ratio of the annual total compensation of Mr. Anderson, who has served as the Company’s Chief
Executive Officer since March 2012, to the annual total compensation of the median employee of the Company (the “Pay Ratio
Disclosure”).



For
fiscal year 2017, the median annual total compensation of all employees of the Company and its consolidated subsidiaries (other
than the Chief Executive Officer) was $91,470. Mr. Anderson’s annual total compensation for fiscal year 2017 for purposes
of the Pay Ratio Disclosure was $1,861,421. Based on this information, for fiscal year 2017, the ratio of the compensation of the
Chief Executive Officer to the median annual total compensation of all other employees was estimated to be 20 to 1.



To
identify, and to determine the annual total compensation of, the median employee, we used the following methodology:



| | · | We collected the payroll data of all employees globally,
whether employed on a full-time, part-time, temporary or seasonal basis as of December 31, 2017.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | We annualized the compensation of all permanent full-time
and part-time employees who were hired by the Company and its consolidated subsidiaries between January 1, 2017 and December 31,
2017. We applied an exchange rate as of December 31, 2017, to convert all international currencies into U.S. dollars.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | We then identified our median employee from our employee population based on this compensation
measure.
| | - | -------------------------------------------------------------------------------------------------------



The
median employee’s annual total compensation represents the amount of such employee’s compensation for fiscal year 2017
that would have been reported in the Summary Compensation Table in accordance with the requirements of Item 402(c)(2)(x) of Regulation
S-K if the employee was a Named Executive Officer, and the annual total compensation of the Chief Executive Officer represents
the amount reported in the “Total” column of our 2017 Summary Compensation Table on page 14 of this Form 10-K/A.



Using
this methodology, we determined that the median employee was a non-exempt, full-time employee located the United States with an
annual total compensation of $91,470 for fiscal year 2017, calculated in accordance with the requirements of Item 402(c)(2)(x)
of Regulation S-K, which includes base pay, overtime pay and the Company’s matching contribution to that employee’s
401(k) plan.



The
Pay Ratio Disclosure presented above is a reasonable estimate. Because the SEC rules for identifying the median employee and calculating
the pay ratio allow companies to use different methodologies, exemptions, estimates and assumptions, the Pay Ratio Disclosure may
not be comparable to the pay ratio reported by other companies.



-29-







| | Item 12. | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.
| | -------- | -----------------------------------------------------------------------------------------------



Beneficial Ownership Table



The following table
sets forth certain information regarding the beneficial ownership of our issued and outstanding ordinary shares by (i) each person
who is known by the Company to own beneficially more than five percent of the outstanding ordinary shares, (ii) each Named Executive
Officer of the Company, (iii) each director and director nominee of the Company and (iv) all directors and executive officers as
a group. Except as otherwise indicated in the footnotes below, such information is provided as of April 27, 2018. According to
SEC rules, a person is the “beneficial owner” of securities if he, she or it has or shares the power to vote them or
to direct their investment or has the right to acquire beneficial ownership of such securities within 60 days through the exercise
of an option, warrant or right, the conversion of a security or otherwise.



|Name and Address of Beneficial Owners(1)                                                  |  | Amount ofBeneficialOwnership(2) |           |  | Percentageof Class(2) | 
|----------------------------------------------------------------------------------------- |  | ------------------------------- | --------- |  | --------------------- | 
|                                                                                          |  |                                 |           |  |                       | 
|>5% Shareholders:                                                                         |  |                                 |           |  |                       | 
|Brandes Investment Partners, L.P. (3) 11988 El Camino Real, Suite 600 San Diego, CA 92130 |  |                                 | 4,808,493 |  |                       | 
|Deerfield Mgmt, L.P.(4) 780 Third Avenue New York, New York 10017                         |  |                                 | 4,558,256 |  |                       | 
|Broadfin Capital, LLC(5) 300 Park Avenue, 25th Floor New York, New York 10022             |  |                                 | 2,591,721 |  |                       | 
|Perceptive Advisors LLC(6) 51 Astor Place New York, NY 10003                              |  |                                 | 2,391,841 |  |                       | 
|Directors, Director Nominees and Named Executive Officers:                                |  |                                 |           |  |                       | 
|Craig R. Stapleton(7)                                                                     |  |                                 | 838,311   |  |                       | 
|Michael S. Anderson(8)                                                                    |  |                                 | 760,250   |  |                       | 
|Francis J.T. Fildes(9)                                                                    |  |                                 | 150,494   |  |                       | 
|Christophe Navarre(10)                                                                    |  |                                 | 154,052   |  |                       | 
|Peter Thornton                                                                            |  |                                 | 5,155     |  |                       | 
|Benoit (Ben) C. Van Assche(11)                                                            |  |                                 | 154,052   |  |                       | 
|Gregory J. Divis(12)                                                                      |  |                                 | 48,100    |  |                       | 
|Michael F. Kanan(13)                                                                      |  |                                 | 75,000    |  |                       | 
|David Monteith(14)                                                                        |  |                                 | 63,750    |  |                       | 
|Phillandas T. Thompson(15)                                                                |  |                                 | 261,250   |  |                       | 
|All directors and executive officers as a group (12 persons) (16)                         |  |                                 | 2,645,114 |  |                       | 



* Represents beneficial ownership of less
than 1% of our outstanding ordinary shares.



| | (1) | Except as stated in the table above or the footnotes below, the address of the named person is
c/o Avadel Pharmaceuticals plc, Block 10-1, Blanchardstown Corporate Park, Ballycoolin, Dublin 15, Ireland.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Unless otherwise stated in the footnotes to this table, we believe that each of the shareholders
named in this table has sole voting and dispositive power with respect to the ordinary shares indicated as beneficially owned.
Ownership percentages are based on 36,745,376 ordinary shares outstanding on April 27, 2018. The number of shares beneficially
owned includes ordinary shares issuable pursuant to the exercise of stock options or warrants that are exercisable and “free
shares,” if any, that will vest within 60 days of April 27, 2018. Ordinary shares issuable pursuant to the exercise of stock
options or warrants that are exercisable and “free shares,” if any, that will vest within 60 days of April 27, 2018
are deemed to be outstanding and beneficially owned by the person to whom such shares are issuable for the purpose of computing
the percentage ownership of that person, but they are not deemed to be outstanding for the purpose of computing the percentage
ownership of any other person.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



-30-







| | (3) | The information in the table and in this footnote is based on a Schedule 13G/A filed with the SEC
on April 9, 2018 by Brandes Investment Partners, L.P., CO-GP, LLC, Brandes Worldwide Holdings, L.P., and Glenn Carlson, each of
whom shares voting power with respect to an aggregate of 4,297,456 of the Company’s ordinary shares and dispositive power
with respect to an aggregate of 4,808,493 of the Company’s ordinary shares. CO-GP, LLC, Brandes Worldwide Holdings, L.P.,
and Glenn Carlson each disclaims beneficial ownership of such ordinary shares except to the extent of their pecuniary interest
therein.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | The
information in the table and in this footnote is based, in part, on a Schedule 13G/A filed with the SEC on February 14, 2018 by
Deerfield Mgmt, L.P., Deerfield Special Situations Fund, L.P., Deerfield Private Design Fund II, L.P., Deerfield Private Design
International II, L.P., Deerfield Management Company, L.P., Breaking Stick Holdings, LLC and James E. Flynn. According to the
Schedule 13G/A, Deerfield Mgmt, L.P., Deerfield Management Company, L.P. and James E. Flynn share voting and dispositive power
with respect to (i) an aggregate of 7,255,494 ordinary shares, consisting of (A) 1,066,299 ordinary shares held by Deerfield Special
Situations Fund, L.P., of which Deerfield Mgmt, L.P. is general partner, (B) 1,346,365 ordinary shares held by Deerfield Private
Design Fund II, L.P., of which Deerfield Mgmt, L.P. is general partner, and (C) 1,542,830 ordinary shares held by Deerfield Private
Design International II, L.P., of which Deerfield Mgmt, L.P. is general partner, and (ii) warrants to purchase ADSs representing
3,300,000 ordinary shares held by Breaking Stick Holdings, LLC, the manager of which is Deerfield Management Company, L.P. and
of which Deerfield Private Design Fund II, L.P. and Deerfield Private Design International II, L.P. are members. On February 23,
2018, Breaking Stick Holdings, LLC exercised in full warrants to purchase ADSs representing 2,200,000 ordinary shares for which
the Company settled these warrants for a combination of cash and the issuance of approximately 602,762 ADSs representing 602,762
ordinary shares. On March 12, 2018, the remaining 1,100,000 warrants expired worthless. As a result, none of Deerfield Mgmt, L.P.,
Deerfield Special Situations Fund, L.P., Deerfield Private Design Fund II, L.P., Deerfield Private Design International II, L.P.,
Deerfield Management Company, L.P., Breaking Stick Holdings, LLC or James E. Flynn has voting and dispositive power with respect
to any warrants of the Company.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (5) | The information in the table and in this footnote is based on a Schedule 13G/A filed with the SEC
on February 13, 2018 by Broadfin Capital, LLC, Broadfin Healthcare Master Fund, Ltd. and Kevin Kotler, each of whom share voting
and dispositive power with respect to an aggregate of 2,591,721 of the Company’s ordinary shares. Broadfin Capital, LLC and
Kevin Kotler each disclaims beneficial ownership of such ordinary shares except to the extent of their pecuniary interest therein.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (6) | The information in the table and in this footnote is based on a Schedule 13G/A filed with the SEC
on February 14, 2018 by Perceptive Advisors LLC, Perceptive Life Sciences Master Fund, Ltd. and Joseph Edelman, each of whom shares
voting and dispositive power with respect to an aggregate of 2,391,841 of the Company’s ordinary shares.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (7) | Includes warrants to purchase ADSs with respect to 334,898 ordinary shares.
| | --- | ---------------------------------------------------------------------------



| | (8) | Includes options to purchase ADSs with respect to 655,500 ordinary shares.
| | --- | --------------------------------------------------------------------------



| | (9) | Includes warrants to purchase ADSs with respect to 135,494 ordinary shares.
| | --- | ---------------------------------------------------------------------------



| | (10) | Represents warrants to purchase ADSs with respect to 154,052 ordinary shares.
| | ---- | -----------------------------------------------------------------------------



| | (11) | Represents warrants to purchase ADSs with respect to 154,052 ordinary shares.
| | ---- | -----------------------------------------------------------------------------



| | (12) | Includes options to purchase ADSs with respect to 37,500 ordinary shares.
| | ---- | -------------------------------------------------------------------------



| | (13) | Represents options to purchase ADSs with respect to 75,000
ordinary shares.
| | ---- | ---------------------------------------------------------------------------



| | (14) | Represents options to purchase ADSs with respect to 63,750 ordinary shares.
| | ---- | ---------------------------------------------------------------------------



| | (15) | Includes options to purchase ADSs with respect to 246,250 ordinary shares.
| | ---- | --------------------------------------------------------------------------



| | (16) | Includes warrants and options to purchase ADSs with respect to 1,979,996 ordinary shares.
| | ---- | -----------------------------------------------------------------------------------------



| | Item 13. | Certain Relationships and Related Transactions, and Director Independence.
| | -------- | --------------------------------------------------------------------------



Policies and Procedures for Related
Person Transactions



The Audit Committee
reviews all related party transactions and similar matters to the extent required by listing standards. The Nominating and Corporate
Governance Committee further assists to ensure that all such related party transactions are thoroughly reviewed on a regular basis
so that such transactions are and remain at arms’ length terms, thus promoting long term shareholder value.



For purposes of related
person transactions as managed by our Audit and Nominating and Corporate Governance Committees, a “related person transaction”
is a transaction, arrangement or relationship (or any series of similar transactions, arrangements or relationships) in which we
(or any of our subsidiaries) were, are or will be a participant, and the amount involved exceeds $120,000 and in which any related
person had, has or will have a direct or indirect interest. For purposes of determining whether a transaction is a related person
transaction, the Committees rely upon Item 404 of Regulation S-K, promulgated under the Securities Exchange Act of 1934, as amended.



-31-







A “related person”
is defined as:



| | • | Any person who is, or at any time since the beginning of our last fiscal year was, one of our directors
or executive officers or a nominee to become one of our directors;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | Any person who is known to be the beneficial owner of more than five percent of any class of our
voting securities;
| | - | -------------------------------------------------------------------------------------------------------------------



| | • | Any immediate family member of any of the foregoing persons, which means any child, stepchild,
parent, stepparent, spouse, sibling, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law or sister-in-law
of the director, executive officer, nominee or more than five percent beneficial owner, and any person (other than a tenant or
employee) sharing the household of such director, executive officer, nominee or more than five percent beneficial owner; and
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | • | Any firm, corporation, or other entity in which any of the foregoing persons is employed or is
a general partner or principal or in a similar position or in which such person has a ten percent or greater beneficial ownership
interest.
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Related Party Transactions



Since January 1, 2017,
there have been no transactions that would require disclosure by the Company under Item 404 of SEC Regulation S-K except as follows.
In connection with our acquisition of Éclat Pharmaceuticals in March 2012, we are required to pay contingent consideration
to the seller, Breaking Stick Holdings LLC, in the amount of 20% of gross profit generated by certain Éclat products. Michael
S. Anderson, our Chief Executive Officer, has a 20% beneficial interest in Breaking Stick Holdings LLC, but does not have the ability
to control this entity by virtue of his minority interest. During 2017, we made payments to Breaking Stick Holdings LLC pursuant
to this requirement in the aggregate amount of approximately $31,600,000.



| | Item 14. | Principal Accountant Fees and Services.
| | -------- | ---------------------------------------



Audit Fees



Background



In 2017, the Audit Committee approved the
engagement of Deloitte & Touche LLP to serve as the Company’s independent registered public accounting firm for the fiscal
year 2017, for purposes of our financial statements for filing under U.S. securities law for the year ending December 31, 2017.
At the 2017 Annual General Meeting of Shareholders, the shareholders voted to ratify the selection of Deloitte & Touche LLP
as the Company’s independent registered accounting firm for the fiscal year 2017.



For its fiscal year
ended December 31, 2015, the Company’s independent registered public accounting firm for purposes of its financial statements
for filing purposes under U.S. securities law was initially PricewaterhouseCoopers Audit (“PwC-France”). On April 15,
2016, PwC-France, informed us that PwC-France declined to stand for reappointment as the Company’s independent registered
public accounting firm for SEC reporting purposes. Also, on April 15, 2016, we engaged PricewaterhouseCoopers LLP (“PwC-U.S.”)
as the Company’s independent registered public accounting firm for SEC reporting purposes for the fiscal year ending December
31, 2016. On June 14, 2016, we dismissed PwC-U.S. as the Company’s independent registered public accounting firm for SEC
reporting purposes. Also, on June 14, 2016, we engaged Deloitte & Touche LLP (“Deloitte”) as the Company’s
independent registered public accounting firm for SEC reporting purposes for the fiscal year ending December 31, 2016. For certain
additional disclosures relating to changes in the Company’s independent registered public accounting firm for purposes of
its financial statements for filing purposes under U.S. securities law, please see the information set forth below under the caption
“Changes in Independent Registered Public Accounting Firms for SEC Reporting Purposes.” It is not expected that any
representatives of Deloitte, PwC-France or PwC-US will be present at the 2018 Annual General Meeting of Shareholders and, accordingly, no such representatives will
have the opportunity to make a statement at the 2018 Annual General Meeting of Shareholders, if they desire to do so, nor, therefore, will any representative of Deloitte,
PwC-France or PwC-US be available at the 2018 Annual General Meeting of Shareholders to respond to appropriate questions.



Pursuant to its charter,
the Audit Committee of our Board or (as applicable) approved in advance each professional service performed by Deloitte during
fiscal year 2017 and considered the possible effect of the provision of such service on the auditors’ independence. Information
relating to fees paid to Deloitte is set forth in the table below.



Under the Sarbanes-Oxley
Act of 2002 and the rules of the SEC promulgated thereunder, the Audit Committee is solely responsible for the selection, appointment,
compensation and oversight of the work of our independent registered public accounting firm. Although submission of the appointment
of an independent registered public accounting firm to shareholders for ratification is not required by law, the Board considers
the appointment of our independent registered public accounting firm to be an important matter of shareholder concern and is submitting
the appointment of Deloitte for ratification by our shareholders, as a matter of good corporate practice.



-32-







Independent Registered Public Accounting
Firm Fees



The following table
summarizes the aggregate fees of our independent registered public accounting firms, billed to us for the fiscal years ended December 31,
2017 and December 31, 2016 for audit and other services:



|                   |  | Fiscal Year Ended December 31, |          
|------------------ |  | ------------------------------ | ---------
|                   |  | 2017                           |          
|                   |  |                                |          
|Audit Fees         |  | $                              | 1,510,000
|Audit-related Fees |  |                                | -        
|Tax Fees           |  |                                | -        
|All Other Fees     |  |                                | -        
|Total Fees         |  | $                              | 1,510,000



Audit Fees.
Audit fees include professional services rendered by public accounting firms for the audit of our annual financial statements in
2017 and 2016, including the reviews of the financial statements included in our quarterly reports on Form 10-Q. This category
also includes fees for assistance with complex accounting and transactions, fees for audits provided in connection with statutory
filings or services that generally only the principal auditor can reasonably provide to a client, and consents and assistance with
and review of documents filed with the SEC, including services related to our 2017 public offerings of our common stock.



Audit-Related Fees.
Audit-related fees consist of amounts for assurance and related services that are reasonably related to the performance of the
audit or review of our financial statements that are not reported under “Audit Fees.”



Tax Fees. Tax
fees include original and amended tax returns, studies supporting tax return amounts as may be required by Internal Revenue Service
regulations, claims for refunds, assistance with tax audits and other work directly affecting or supporting the payment of taxes,
planning, research and advice supporting our efforts to maximize the tax efficiency of our operations for fiscal years 2017 and
2016.



All Other Fees.
All other fees are fees for products or services other than those in the above three categories.



Pre-Approval
Policy



The Audit Committee
has adopted a policy for the provision of audit services and permitted non-audit services by our independent registered public
accounting firm. Our Chief Financial Officer has primary responsibility to the Audit Committee for administration and enforcement
of this policy and for reporting non-compliance. Under the policy, our Audit Committee receives a presentation of an annual budget
and plan for audit services and for any proposed audit-related, tax or other non-audit services to be performed by the independent
registered public accounting firm.



Changes in Independent Registered
Public Accounting Firms for SEC Reporting Purposes



Background



The following disclosures pertain to changes
in independent registered public accounting firms for SEC reporting purposes which took place during 2016 with respect to our predecessor
Flamel Technologies S.A., a French société anonyme (“Flamel”).  Avadel is the successor to
Flamel as the result of the merger of Flamel with and into Avadel which was completed at 11:59:59 p.m., Central Europe Time, on
December 31, 2016 (the “Merger”). Immediately prior to the Merger, Avadel was a wholly owned subsidiary of Flamel. 
As a result of the Merger, (i) Flamel ceased to exist as a separate entity and Avadel continued as the surviving entity and assumed
all of the assets and liabilities of Flamel as of the time the Merger was consummated; (ii) each of Flamel’s outstanding
ordinary shares was cancelled and exchanged for one (1) newly issued Avadel ordinary share and (iii) each outstanding ADS representing
a Flamel ordinary share was cancelled and exchanged one (1) ADS representing one (1) Avadel ordinary share. Thus, the Merger changed
the jurisdiction of our incorporation from France to Ireland, and an ordinary share of Avadel held (either directly or represented
by an ADS) immediately after the Merger continued to represent the same proportional equity interest owned by the holder of a share
of Flamel immediately prior to the Merger. For SEC reporting purposes, Avadel is the successor issuer to Flamel.  Therefore,
unless the context otherwise requires, for purposes of the following disclosures the “Company,” and the pronouns “we,”
“us” and similar terms, refer to Flamel when describing events occurring or circumstances existing prior to the completion
of the “Merger.”



-33-







Declination of PricewaterhouseCoopers
Audit and Engagement of PricewaterhouseCoopers LLP



On April 15, 2016,
PricewaterhouseCoopers Audit (“PwC-France”), informed us that PwC-France declined to stand for reappointment as the
Company’s independent registered public accounting firm for SEC reporting purposes. Also, on April 15, 2016, we engaged PricewaterhouseCoopers
LLP (“PwC-U.S.”) as the Company’s independent registered public accounting firm for SEC reporting purposes for
the fiscal year ending December 31, 2016.



During the fiscal year
ended December 31, 2015 and the subsequent period prior to April 15, 2016 (the date on which PwC-France declined to stand for reappointment),
there were no disagreements with PwC-France on any matter of accounting principles or practices, financial statement disclosure
or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of PwC-France, would have caused such
firm to make reference to the subject matter of the disagreements in its reports on our financial statements for any applicable
period.



During the fiscal year
ended December 31, 2015 and the subsequent period prior to April 15, 2016 (the date on which PwC-France declined to stand for reappointment),
there were no reportable events (as defined in Item 304(a)(1)(v) of Regulation S-K), except as follows. In Item 9A of Company’s
annual report on Form 10-K for the year ended December 31, 2015 as filed with the SEC on March 15, 2016 (the “2015 Form 10-K”),
management of the Company reported on its evaluation of the effectiveness of the Company’s disclosure controls and procedures
(as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934) as of December 31, 2015. The 2015 Form
10-K stated that, based on such evaluation, the Company’s Chief Executive Officer and Chief Financial Officer concluded that
the Company did not maintain effective internal control over financial reporting as of December 31, 2015, based on criteria in
Internal Control-Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission. Such
conclusion was based on material weaknesses in the Company’s internal control over financial reporting as of December 31,
2015 which are described as follows: (a) lack of sufficient personnel; (b) ineffective controls over segregation of duties and
restricted access for processes, including an assessment of incompatible management responsibilities relating to (i)
the review, approval and documentation related to journal entries in the U.S.; (ii) the review, approval, and ongoing
maintenance of third party vendor contracts and vendor payments; (iii) the cash payment process in the U.S.; and
(iv) the U.S. payroll process; (c) lack of effective controls over the review and approval of product prices, the
review and accounting for rebate arrangements under customer contracts and the use of service providers in the revenue process;
(d) lack of effective controls related to quarterly and year-end income tax accounting; (e) lack of effective controls over certain
information technology used in the preparation of the financial statements; (f) lack of effective controls over the financial close
process; and (g) lack of an internal audit function sufficient to monitor control activities. More detailed descriptions of these
material weaknesses were set forth in Item 9A of the 2015 Form 10-K.



The audit report of
PwC-France included in the 2015 Form 10-K with respect to the Company’s internal control over financial reporting opined
that the Company did not maintain effective internal control over financial reporting as of December 31, 2015; however, the audit
report of PwC-France included in the 2015 Form 10-K with respect to the Company’s financial statements and financial statement
schedule expressed an unqualified opinion on such consolidated financial statements and financial statement schedule.



The material weaknesses
identified by management and described in the 2015 Form 10-K were discussed by the Company’s management and the Audit Committee
with PwC-France. The Audit Committee authorized PwC-France to respond fully to the inquiries of the successor independent registered
public accounting firm concerning all matters related to any audit work performed by PwC-France, including the material weaknesses
referred to above.



During the fiscal year
ended December 31, 2015 and the subsequent period prior to April 15, 2016 (the date of engagement of PwC-U.S.), neither the Company
nor anyone on its behalf consulted PwC-U.S. regarding (i) the application of accounting principles to any specified transaction,
either completed or proposed, or the type of audit opinion that might be rendered on the Company’s financial statements,
and either a written report was provided to the Company or oral advice was provided that PwC-U.S. concluded was an important factor
considered by the Company in reaching a decision as to the accounting, auditing or financial reporting issue; or (ii) any matter
that was either the subject of a disagreement (as defined in Item 304(a)(1)(v) of Regulation S-K) or a reportable event (as defined
in Item 304(a)(1)(v) of Regulation S-K).



Dismissal of PricewaterhouseCoopers
LLP and Engagement of Deloitte & Touche LLP



On June 14, 2016, we
dismissed PwC-U.S. as the Company’s independent registered public accounting firm for SEC reporting purposes. The decision
to dismiss PwC-U.S. as the Company’s independent registered public accounting firm was approved by both the Company’s
Audit Committee and the Company’s Board of Directors. Also, on June 14, 2016, we engaged Deloitte & Touche LLP (“Deloitte”)
as the Company’s independent registered public accounting firm for SEC reporting purposes for the fiscal year ending December
31, 2016.



-34-







Because PwC-U.S. had
been engaged as the Company’s independent registered public accounting firm on April 15, 2016, such firm did not issue a
report on the financial statements of the Company for any fiscal year prior to such date. During the period since April 15, 2016
(the date on which PwC-U.S. was engaged as the Company’s independent registered public accounting firm) through June 14,
2016 (the date of dismissal of PwC-U.S.), there were no reportable events (as defined in Item 304(a)(1)(v) of Regulation S-K),
except as follows. In Part I, Item 4 of the Company’s quarterly report on Form 10-Q for the fiscal quarter ended March 31,
2016, as filed with the SEC on May 10, 2016 (the “First Quarter 2016 Form 10-Q”), management of the Company reported
on its evaluation of the effectiveness of the Company’s disclosure controls and procedures (as defined in Rules 13a-15(e)
and 15d-15(e) under the Securities Exchange Act of 1934) as of March 31, 2016, the end of the period covered by the First Quarter
2016 Form 10-Q. The First Quarter 2016 Form 10-Q stated that, based on such evaluation, the Company’s Chief Executive Officer
and Chief Financial Officer concluded that, as of March 31, 2016, the Company’s disclosure controls and procedures were not
effective because the material weaknesses in the Company’s internal control over financial reporting described above under
the caption“– Changes in Independent Registered Public Accounting Firms for SEC Reporting Purposes – Declination
of PricewaterhouseCoopers Audit and Engagement of PricewaterhouseCoopers LLP” continued to exist as of March 31, 2016.
More detailed descriptions of these material weaknesses were set forth in Item 9A of the 2015 Form 10-K.



During the fiscal year
ended December 31, 2015 and the subsequent period prior to June 14, 2016 (the date of dismissal of PwC-U.S.), there were no disagreements
with PwC-U.S. on any matter of accounting principles or practices, financial statement disclosure or auditing scope or procedure,
which disagreements, if not resolved to the satisfaction of PwC-U.S., would have caused such firm to make reference to the subject
matter of the disagreements in its reports on our financial statements for any applicable period.



The material weaknesses
identified by management and described in the 2015 Form 10-K and referenced in the First Quarter Form 2016 10-Q were discussed
by the Company’s management and the Audit Committee with PwC-U.S. The Audit Committee authorized PwC-U.S. to respond fully
to the inquiries of the successor independent registered public accounting firm concerning all matters related to any audit work
performed by PwC-U.S., including the material weaknesses referred to above.



During the fiscal year
ended December 31, 2015 and the interim period of 2016 prior to June 14, 2016 (the date of engagement of Deloitte), neither the
Company nor anyone on its behalf consulted Deloitte regarding (i) the application of accounting principles to any specified transaction,
either completed or proposed, or the type of audit opinion that might be rendered on the Company’s financial statements,
and either a written report was provided to the Company or oral advice was provided that Deloitte concluded was an important factor
considered by the Company in reaching a decision as to the accounting, auditing or financial reporting issue; or (ii) any matter
that was either the subject of a disagreement (as defined in Item 304(a)(1)(v) of Regulation S-K) or a reportable event (as defined
in Item 304(a)(1)(v) of Regulation S-K).



Remediation of Previously Reported Material
Weaknesses



As described above,
the Company previously reported material weaknesses in its 2015 Form 10-K. As more fully described in our annual report on Form
10-K for the year ended December 31, 2017 as filed with the SEC on March 16, 2018, we identified and implemented additional processes,
procedures and controls to improve the effectiveness of our internal control over financial reporting and disclosure controls and
procedures. We regularly reviewed our progress toward remediating the previously reported material weaknesses with our audit committee
during 2016 and 2017. Leading this remediation process was our Senior Vice President and Chief Financial Officer and our Chief
Accounting Officer. Assisting management with the remediation process was a nationally recognized consulting firm who, under the
direction of management, created and enhanced controls documentation, assisted management in the implementation of improvements
or changes to the existing internal control structure and tested such processes, procedures and controls to support management’s
conclusions surrounding the design and operating effectiveness of management’s internal controls over financial reporting.
As of December 31, 2017, management evaluated the design and operational effectiveness of all our remediation activities and concluded
that we have sufficient evidence that the processes and controls relating to all areas where we previously reported material weaknesses
have been adequately designed and were operating effectively. As a result, management has concluded that all previously reported
material weaknesses have been remediated as of December 31, 2017.



-35-







PART IV



| | Item 15. | Exhibits and Financial Statement Schedules
| | -------- | ------------------------------------------



| | (a) | Documents filed as part of this report:
| | --- | ---------------------------------------



| | 1. | Financial Statements
| | -- | --------------------



See Item
8 - Financial Statements and Supplementary Data of Part II of the Company’ Annual Report on Form 10-K for the year ended
December 31, 2017, filed on March 16, 2018.



| | 2. | Financial Statement Schedules
| | -- | -----------------------------



See below for Schedule II: Valuation and
Qualifying Accounts. All other schedules are omitted as they are not applicable, not required or the information is included in
the consolidated financial statements or related notes to the consolidated financial statements.



Schedule II

Valuation and Qualifying Accounts

(In thousands)



|Deferred Tax Asset Valuation Allowance: |  | Balance, Beginning of Period |        |  | Additions (a) |   |       | Deductions (b) |  |   | Other Changes (c) |   |  | Balance, End of Period |       
|--------------------------------------- |  | ---------------------------- | ------ |  | ------------- | - | ----- | -------------- |  | - | ----------------- | - |  | ---------------------- | ------
|2017                                    |  | $                            | 7,599  |  |               | $ | 391   |                |  | $ | (664              | ) |  | $                      | 8,028 
|2016                                    |  | $                            | 45,516 |  |               | $ | 6,873 |                |  | $ | (42,417           | ) |  | $                      | (2,373
|2015                                    |  |                              | 57,980 |  |               |   | 4,312 |                |  |   | (11,737           | ) |  |                        | (5,039



| | a. | Additions to the deferred tax asset valuation allowance relate to movements on certain French,
Irish and U.S. deferred tax assets where we continue to maintain a valuation allowance until sufficient positive evidence exists
to support reversal.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | b. | Deductions to the deferred tax asset valuation allowance include movements relating to utilization
and removal of net operating losses and tax credit carryforwards, release in valuation allowance and other movements including
adjustments following finalization of tax returns.
| | -- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | c. | Other changes to the deferred tax asset valuation allowance including currency translation adjustments
recorded directly in equity and account method changes.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3. | Exhibits required by Item 601 of Regulation
S-K
| | -- | -----------------------------------------------



The information required by this Section
(a)(3) of Item 15 is set forth on the exhibit index that follows the Signatures page of this Form 10-K.



Index to Exhibits



|Exhibit Number |  | Exhibit Description                                                                                                                                                                                                                                                                                                                                                
|-------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|               |  |                                                                                                                                                                                                                                                                                                                                                                    
|3.1            |  | Constitution (containing the Memorandum and Articles of Association) of Avadel Pharmaceuticals plc (incorporated by reference to Appendix 15 of Exhibit 2.1 to the registrant’s current report on Form 8-K, filed on July 1, 2016)                                                                                                                                 
|               |  |                                                                                                                                                                                                                                                                                                                                                                    
|4.1            |  | Guaranty dated January 1, 2017 by Avadel Pharmaceuticals plc in favor of Breaking Stick Holdings, LLC (f/k/a Éclat Holdings, LLC) with respect to obligations under the Note Agreement filed as Exhibit 4.1 (incorporated by reference to Exhibit 4.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2016, filed on March 28, 2017)
|               |  |                                                                                                                                                                                                                                                                                                                                                                    
|4.2            |  | Warrant to purchase 1,100,000 American Depositary Shares, each representing one ordinary share of Avadel Pharmaceuticals plc (incorporated by reference to Exhibit 4.1 to the registrant’s Post-Effective Amendment No. 2 to Form F-3 registration statement (No. 333-183961) on Form S-3, filed on January 6, 2017)                                               



-36-









|4.3   |  | Warrant to purchase 2,200,000 American Depositary Shares, each representing one ordinary share of Avadel Pharmaceuticals plc (incorporated by reference to Exhibit 4.2 to the registrant’s Post-Effective Amendment No. 2 to Form F-3 registration statement (No. 333-183961) on Form S-3, filed on January 6, 2017)                                                                                                   
|----- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.1  |  | Deposit Agreement dated as of January 3, 2017 among Avadel Pharmaceuticals plc, The Bank of New York, as Depositary, and holders from time to time of American Depositary Shares issued thereunder (including as an exhibit the form of American Depositary Receipt) (incorporated by reference to Exhibit 1.1 to the registrant’s current report on Form 8-K12B, filed on January 4, 2017 and amended January 6, 2017)
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.2* |  | Note Agreement among Flamel Technologies S.A., Flamel U.S. Holdings, Inc. and Éclat Holdings, LLC dated March 13, 2012 (incorporated by reference to Exhibit 4.1 to the registrant’s current report on Form 6-K, filed on March 21, 2012)                                                                                                                                                                              
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.3  |  | Registration Rights Agreement between Flamel Technologies S.A. and Éclat Holdings, LLC dated March 13, 2012 (incorporated by reference to Exhibit 4.5 to the registrant’s current report on Form 6-K, filed on March 21, 2012)                                                                                                                                                                                         
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.4  |  | Facility Agreement among Flamel US Holdings, Inc., Deerfield Private Design Fund II, L.P. and Deerfield Private Design International II, L.P. dated December 31, 2012 (incorporated by reference to Exhibit 4.7 to the registrant’s annual report on Form 20-F for the year ended December 31, 2012, filed on April 30, 2013)                                                                                          
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.5* |  | Royalty Agreement among Éclat Pharmaceuticals LLC, Horizon Santé FLML, Sarl and Deerfield Private Design Fund II, L.P. dated December 31, 2012 (incorporated by reference to Exhibit 4.8 to the registrant’s annual report on Form 20-F for the year ended December 31, 2012, filed on April 30, 2013)                                                                                                                 
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.6* |  | Security Agreement between Éclat Pharmaceuticals, LLC and Deerfield Private Design Fund II, L.P. and Horizon Santé FLML, Sarl dated February 4, 2013 (incorporated by reference to Exhibit 4.9 to the registrant’s annual report on Form 20-F for the year ended December 31, 2012, filed on April 30, 2013)                                                                                                           
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.7  |  | Broadfin Facility Agreement effective as of December 3, 2013 (incorporated by reference to Exhibit 4.9 to the registrant’s annual report on Form 20-F for the year ended December 31, 2013, filed on April 30, 2014)                                                                                                                                                                                                   
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.8* |  | Broadfin Royalty Agreement dated as of December 3, 2013 (incorporated by reference to Exhibit 4.10 to the registrant’s annual report on Form 20-F for the year ended December 31, 2013, filed on April 30, 2014)                                                                                                                                                                                                       
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.9  |  | Asset Purchase Agreement by and among Flamel Technologies S.A. and Recipharm Pessac dated November 26, 2014 (incorporated by reference to Exhibit 4.11 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                                                                                   
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.10 |  | Master Agreement on Supply of Services and Products by and between Avadel Technologies S.A. and Recipharm Pessac dated December 1, 2014 (incorporated by reference to Exhibit 4.12 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                                                       
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.11 |  | Service Agreement by and between Flamel Technologies S.A. and Recipharm Pessac dated December 1, 2014 (incorporated by reference to Exhibit 4.13 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                                                                                         
|      |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.12 |  | Supply Agreement by and between Flamel Technologies S.A. and Recipharm Pessac dated December 1, 2014 (incorporated by reference to Exhibit 4.14 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                                                                                          



-37-







|10.13* |  | Membership Interest Purchase Agreement by and among Éclat Holdings LLC, Éclat Pharmaceuticals LLC, Flamel Technologies S.A. and Flamel US Holdings Inc. dated March 13, 2012 (incorporated by reference to Exhibit 4.15 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                    
|------ |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.14* |  | Exclusive License Agreement by and between Elan Pharma International Limited and Flamel Ireland Limited dated September 30, 2015 (incorporated by reference to Exhibit 10.14 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                               
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.15  |  | Lease Agreement by and between Nine East, LLC and Eclat Pharmaceuticals LLC dated July 23, 2013 (incorporated by reference to Exhibit 10.15 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.16  |  | Lease Agreement by and between Grove II LLC and Eclat Pharmaceuticals LLC dated October 5, 2015 (incorporated by reference to Exhibit 10.16 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.17  |  | Lease Agreement by and between Channor Limited, Blanchardstown Corporate Park Management Limited, Flamel Ireland Limited, and Flamel Technologies S.A. dated July 3, 2015 (incorporated by reference to Exhibit 10.17 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                      
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.18‡ |  | Employment Agreement by and between Flamel Technologies S.A. and Sandra Hatten dated July 8, 2015 (incorporated by reference to Exhibit 10.18 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.19‡ |  | Employment Agreement by and between Flamel Technologies S.A. and Phillandas T. Thompson dated July 7, 2015 (incorporated by reference to Exhibit 10.19 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                     
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.20  |  | Membership Interest Purchase Agreement dated as of February 5, 2016 by and among James Flynn, Peter Steelman, Deerfield CSF, LLC, FSC Holding Company, LLC, FSC Therapeutics, LLC, FSC Laboratories, Inc., Flamel Technologies SA, and Flamel US Holdings, Inc. (incorporated by reference to Exhibit 10.20 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.21‡ |  | Rules Governing the Free Share Plan - December 2014 (incorporated by reference to Exhibit 10.21 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                                                            
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.22‡ |  | Rules Governing the Free Share Plan - December 2014 (incorporated by reference to Exhibit 10.22 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                                                            
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.23‡ |  | June 2015 Stock Warrant Rules (incorporated by reference to Exhibit 10.23 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                                                                                  
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.24‡ |  | Subscription Form of Stock Warrant (incorporated by reference to Exhibit 10.24 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                                                                             
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.25‡ |  | December 2015 Stock Option Rules (incorporated by reference to Exhibit 10.25 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                                                                               
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.26‡ |  | Form of Stock Option Grant Letter (incorporated by reference to Exhibit 10.26 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                                                                              



-38-







|10.27  |  | Common Draft Terms of Cross-Border Merger dated as of June 29, 2016 between Flamel Technologies S.A. and Avadel Pharmaceuticals Limited (subsequently renamed Avadel Pharmaceuticals plc) (incorporated by reference to Exhibit 2.1 to the registrant’s current report on Form 8-K, filed on July 1, 2016)                           
|------ |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.28‡ |  | Rules Governing the Free Share Plan - August 2016 (incorporated by reference to Exhibit 99.1 to the registrant’s Registration Statement (No. 333-213154) on Form S-8, filed on August 16, 2016)                                                                                                                                      
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.29‡ |  | August 2016 Stock Option Rules (incorporated by reference to Exhibit 99.2 to the registrant’s Registration Statement (No. 333-213154) on Form S-8, filed on August 16, 2016)                                                                                                                                                         
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.30‡ |  | August 2016 Stock Warrant Rules (incorporated by reference to Exhibit 99.3 to the registrant’s Registration Statement (No. 333-213154) on Form S-8, filed on August 16, 2016)                                                                                                                                                        
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.31‡ |  | Form of stock option grant letter for 2016 Stock Option Rules (incorporated by reference to Exhibit 10.31 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2016, filed on March 28, 2017)                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.32‡ |  | Employment Agreement by and between Avadel Pharmaceuticals plc and Gregory J. Divis, dated January 4, 2017 (incorporated by reference to Exhibit 10.32 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2016, filed on March 28, 2017)                                                                 
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.33‡ |  | Employment Agreement by and between Avadel Management Corporation and Michael S. Anderson dated August 15, 2017 (incorporated by reference to Exhibit 10.1 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                    
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.34‡ |  | Employment Agreement by and between Avadel Management Corporation and Gregory J. Divis dated September 5, 2017 (incorporated by reference to Exhibit 10.2 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                     
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.35‡ |  | Employment Agreement by and between Avadel Management Corporation and Sandra Hatten dated August 15, 2017 (incorporated by reference to Exhibit 10.3 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                          
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.36‡ |  | Employment Agreement by and between Avadel Management Corporation and Michael F. Kanan dated September 5, 2017 (incorporated by reference to Exhibit 10.4 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                     
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.37‡ |  | Employment Agreement by and between Avadel Management Corporation and Phillandas T. Thompson dated August 15, 2017 (incorporated by reference to Exhibit 10.5 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                 
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.38* |  | Exclusive Right of Negotiation Agreement by and between Avadel Specialty Pharmaceuticals, LLC and Serenity Pharmaceuticals, LLC dated as of August 11, 2017 (incorporated by reference to Exhibit 10.6 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)        
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.39* |  | Exclusive License and Assignments Agreement by and between Avadel Specialty Pharmaceuticals, LLC and Serenity Pharmaceuticals, LLC dated as of September 1, 2017 (incorporated by reference to Exhibit 10.7 to the registrant's Quarterly Report on Form 10-Q/A for the quarter ended September 30, 2017, filed on November 17, 2017)
|       |  |                                                                                                                                                                                                                                                                                                                                      
|10.40* |  | Manufacturing Agreement by and between Renaissance Lakewood, LLC (formerly DPT Lakewood, LLC) and Serenity Pharmaceuticals, LLC dated as of July 14, 2014 (incorporated by reference to Exhibit 10.8A to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)         



-39-







|10.41  |  | Renaissance Agreements Assignment and Assumption Agreement by and between Avadel Specialty Pharmaceuticals, LLC and Serenity Pharmaceuticals, LLC dated as of September 1, 2017 (incorporated by reference to Exhibit 10.8B to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                         
|------ |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.42  |  | Master Manufacturing Services Agreement by and between Patheon UK Limited and Éclat Pharmaceuticals L.L.C. dated as of November 8, 2012 (incorporated by reference to Exhibit 10.9 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                                                  
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.43* |  | Asset Purchase Agreement by and among Cerecor, Inc. and Avadel Pharmaceuticals (USA), Inc., Avadel Pediatrics, Inc., FSC Therapeutics, LLC, Avadel US Holdings, Inc. and Avadel Pharmaceuticals plc dated as of February 12, 2018 (incorporated by reference to Exhibit 10.43 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.44* |  | License and Development Agreement by and between Cerecor, Inc. and Flamel Ireland Limited operating under the trade name of Avadel Ireland dated as of February 16, 2018 (filed herewith)                                                                                                                                                                                                  
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.45* |  | Guarantee by Avadel US Holdings, Inc. and Avadel Pharmaceuticals plc in favor of Deerfield CSF, LLC, Peter Steelman and James Flynn dated as of February 16, 2018 (incorporated by reference to Exhibit 10.45 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                                                
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.46* |  | Guarantee by Armistice Capital Master Fund, Ltd. in favor of Avadel US Holdings, Inc. dated as of February 16, 2018 (incorporated by reference to Exhibit 10.46 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|14.1   |  | Code of Business Conduct and Ethics (incorporated by reference to Exhibit 14.1 to the registrant’s current report on Form 8-K, filed on March 7, 2017)                                                                                                                                                                                                                                     
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|14.2   |  | Financial Integrity Policy (incorporated by reference to Exhibit 14.2 to the registrant’s current report on Form 8-K, filed on March 7, 2017)                                                                                                                                                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|21.1   |  | List of Subsidiaries (incorporated by reference to
Exhibit  21.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16,
2018)                                                                                                                                                                                                             
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|23.1   |  | Consent of PricewaterhouseCoopers Audit (incorporated by reference to Exhibit 23.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                                                                                                                                                                           
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|23.2   |  | Consent of Deloitte & Touche, LLP (incorporated by reference to Exhibit 23.2 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                                                                                                                                                                                 
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|31.1   |  | Certification of the Chief Executive Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 31.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                            
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|31.2   |  | Certification of the Principal Financial Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 31.2 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                        
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|31.3   |  | Certification of the Chief Executive Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith)                                                                                                                                                                                    



-40-







|31.4 |  | Certification of the Principal Financial Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith)                                                                                                     
|---- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|     |  |                                                                                                                                                                                                                                                                                                                 
|32.1 |  | Certification of the Chief Executive Officer pursuant to USC Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 32.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018) (1)    
|     |  |                                                                                                                                                                                                                                                                                                                 
|32.2 |  | Certification of the Principal Financial Officer pursuant to USC Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 32.2 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018) (1)
|     |  |                                                                                                                                                                                                                                                                                                                 
|101  |  | Interactive Data Files (2)                                                                                                                                                                                                                                                                                      



*Confidential treatment has been
requested for the redacted portions of this agreement. A complete copy of the agreement, including the redacted portions, has been
filed separately with the Securities and Exchange Commission.



‡Management contract or
compensatory plan or arrangement filed pursuant to Item 15(b) of Form 10-K.



(1) This certification accompanies
the Original Form 10-K to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be
incorporated by reference into any filing of the registrant under the Securities Act of 1933 or the Securities Exchange Act
of 1934 (whether made before or after the date of the
Original Form 10-K, irrespective of any general incorporation language
contained in such filing.



(2) Previously filed or furnished, as applicable,
as an exhibit to the Original Form 10-K.



-41-







SIGNATURES



Pursuant to the requirements of Section
13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this Report to be signed on its behalf by the
undersigned, thereunto duly authorized.



|                      |     | AVADEL PHARMACEUTICALS PLC       
|--------------------- | --- | ---------------------------------
|                      |     |                                  
|Dated: April 30, 2018 | By: | /s/ Michael S. Anderson          
|                      |     | Name:   Michael S. Anderson      
|                      |     | Title:    Chief Executive Officer



Pursuant to the requirements of the Securities
Exchange Act of 1934, this Report has been signed below by the following persons on behalf of the registrant and in the capacities
and on the dates indicated.



|Signature               |  | Title                                                             |  | Date          
|----------------------- |  | ----------------------------------------------------------------- |  | --------------
|                        |  |                                                                   |  |               
|/s/ Michael S. Anderson |  | Chief Executive Office (Principal Executive Officer) and Director |  | April 30, 2018
|Michael S. Anderson     |  |                                                                   |  |               
|                        |  |                                                                   |  |               
|/s/ Michael F. Kanan    |  | Chief Financial Officer (Principal Financial Officer)             |  | April 30, 2018
|Michael F. Kanan        |  |                                                                   |  |               
|                        |  |                                                                   |  |               
|/s/ David P. Gusky      |  | Corporate Controller (Principal Accounting Officer)               |  | April 30, 2018
|David P. Gusky          |  |                                                                   |  |               
|                        |  |                                                                   |  |               
|*                       |  | Non-Executive Chairman of the Board and Director                  |  | April 30, 2018
|Craig R. Stapleton      |  |                                                                   |  |               
|                        |  |                                                                   |  |               
|*                       |  | Director                                                          |  | April 30, 2018
|Peter Thornton          |  |                                                                   |  |               
|                        |  |                                                                   |  |               
|*                       |  | Director                                                          |  | April 30, 2018
|Francis J.T. Fildes     |  |                                                                   |  |               
|                        |  |                                                                   |  |               
|*                       |  | Director                                                          |  | April 30, 2018
|Benoit Van Assche       |  |                                                                   |  |               
|                        |  |                                                                   |  |               
|*                       |  | Director                                                          |  | April 30, 2018
|Christophe Navarre      |  |                                                                   |  |               



|*     By: | /s/ Michael S. Anderson | 
|--------- | ----------------------- | 
|          | Michael S. Anderson as  | 
|          | Attorney-in-Fact        | 



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EXHIBIT INDEX



|Exhibit Number |  | Exhibit Description                                                                                                                                                                                                                                                                                                                                                                                                    
|-------------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|3.1            |  | Constitution (containing the Memorandum and Articles of Association) of Avadel Pharmaceuticals plc (incorporated by reference to Appendix 15 of Exhibit 2.1 to the registrant’s current report on Form 8-K, filed on July 1, 2016)                                                                                                                                                                                     
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|4.1            |  | Guaranty dated January 1, 2017 by Avadel Pharmaceuticals plc in favor of Breaking Stick Holdings, LLC (f/k/a Éclat Holdings, LLC) with respect to obligations under the Note Agreement filed as Exhibit 4.1 (incorporated by reference to Exhibit 4.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2016, filed on March 28, 2017)                                                    
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|4.2            |  | Warrant to purchase 1,100,000 American Depositary Shares, each representing one ordinary share of Avadel Pharmaceuticals plc (incorporated by reference to Exhibit 4.1 to the registrant’s Post-Effective Amendment No. 2 to Form F-3 registration statement (No. 333-183961) on Form S-3, filed on January 6, 2017)                                                                                                   
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|4.3            |  | Warrant to purchase 2,200,000 American Depositary Shares, each representing one ordinary share of Avadel Pharmaceuticals plc (incorporated by reference to Exhibit 4.2 to the registrant’s Post-Effective Amendment No. 2 to Form F-3 registration statement (No. 333-183961) on Form S-3, filed on January 6, 2017)                                                                                                   
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.1           |  | Deposit Agreement dated as of January 3, 2017 among Avadel Pharmaceuticals plc, The Bank of New York, as Depositary, and holders from time to time of American Depositary Shares issued thereunder (including as an exhibit the form of American Depositary Receipt) (incorporated by reference to Exhibit 1.1 to the registrant’s current report on Form 8-K12B, filed on January 4, 2017 and amended January 6, 2017)
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.2*          |  | Note Agreement among Flamel Technologies S.A., Flamel U.S. Holdings, Inc. and Éclat Holdings, LLC dated March 13, 2012 (incorporated by reference to Exhibit 4.1 to the registrant’s current report on Form 6-K, filed on March 21, 2012)                                                                                                                                                                              
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.3           |  | Registration Rights Agreement between Flamel Technologies S.A. and Éclat Holdings, LLC dated March 13, 2012 (incorporated by reference to Exhibit 4.5 to the registrant’s current report on Form 6-K, filed on March 21, 2012)                                                                                                                                                                                         
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.4           |  | Facility Agreement among Flamel US Holdings, Inc., Deerfield Private Design Fund II, L.P. and Deerfield Private Design International II, L.P. dated December 31, 2012 (incorporated by reference to Exhibit 4.7 to the registrant’s annual report on Form 20-F for the year ended December 31, 2012, filed on April 30, 2013)                                                                                          
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.5*          |  | Royalty Agreement among Éclat Pharmaceuticals LLC, Horizon Santé FLML, Sarl and Deerfield Private Design Fund II, L.P. dated December 31, 2012 (incorporated by reference to Exhibit 4.8 to the registrant’s annual report on Form 20-F for the year ended December 31, 2012, filed on April 30, 2013)                                                                                                                 
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.6*          |  | Security Agreement between Éclat Pharmaceuticals, LLC and Deerfield Private Design Fund II, L.P. and Horizon Santé FLML, Sarl dated February 4, 2013 (incorporated by reference to Exhibit 4.9 to the registrant’s annual report on Form 20-F for the year ended December 31, 2012, filed on April 30, 2013)                                                                                                           
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.7           |  | Broadfin Facility Agreement effective as of December 3, 2013 (incorporated by reference to Exhibit 4.9 to the registrant’s annual report on Form 20-F for the year ended December 31, 2013, filed on April 30, 2014)                                                                                                                                                                                                   
|               |  |                                                                                                                                                                                                                                                                                                                                                                                                                        
|10.8*          |  | Broadfin Royalty Agreement dated as of December 3, 2013 (incorporated by reference to Exhibit 4.10 to the registrant’s annual report on Form 20-F for the year ended December 31, 2013, filed on April 30, 2014)                                                                                                                                                                                                       





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|10.9   |  | Asset Purchase Agreement by and among Flamel Technologies S.A. and Recipharm Pessac dated November 26, 2014 (incorporated by reference to Exhibit 4.11 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                                                                                     
|------ |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.10  |  | Master Agreement on Supply of Services and Products by and between Avadel Technologies S.A. and Recipharm Pessac dated December 1, 2014 (incorporated by reference to Exhibit 4.12 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                                                         
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.11  |  | Service Agreement by and between Flamel Technologies S.A. and Recipharm Pessac dated December 1, 2014 (incorporated by reference to Exhibit 4.13 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                                                                                           
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.12  |  | Supply Agreement by and between Flamel Technologies S.A. and Recipharm Pessac dated December 1, 2014 (incorporated by reference to Exhibit 4.14 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                                                                                            
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.13* |  | Membership Interest Purchase Agreement by and among Éclat Holdings LLC, Éclat Pharmaceuticals LLC, Flamel Technologies S.A. and Flamel US Holdings Inc. dated March 13, 2012 (incorporated by reference to Exhibit 4.15 to the registrant’s annual report on Form 20-F for the year ended December 31, 2014, filed on April 30, 2015)                                                                                    
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.14* |  | Exclusive License Agreement by and between Elan Pharma International Limited and Flamel Ireland Limited dated September 30, 2015 (incorporated by reference to Exhibit 10.14 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                               
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.15  |  | Lease Agreement by and between Nine East, LLC and Eclat Pharmaceuticals LLC dated July 23, 2013 (incorporated by reference to Exhibit 10.15 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.16  |  | Lease Agreement by and between Grove II LLC and Eclat Pharmaceuticals LLC dated October 5, 2015 (incorporated by reference to Exhibit 10.16 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.17  |  | Lease Agreement by and between Channor Limited, Blanchardstown Corporate Park Management Limited, Flamel Ireland Limited, and Flamel Technologies S.A. dated July 3, 2015 (incorporated by reference to Exhibit 10.17 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                      
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.18‡ |  | Employment Agreement by and between Flamel Technologies S.A. and Sandra Hatten dated July 8, 2015 (incorporated by reference to Exhibit 10.18 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.19‡ |  | Employment Agreement by and between Flamel Technologies S.A. and Phillandas T. Thompson dated July 7, 2015 (incorporated by reference to Exhibit 10.19 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                     
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.20  |  | Membership Interest Purchase Agreement dated as of February 5, 2016 by and among James Flynn, Peter Steelman, Deerfield CSF, LLC, FSC Holding Company, LLC, FSC Therapeutics, LLC, FSC Laboratories, Inc., Flamel Technologies SA, and Flamel US Holdings, Inc. (incorporated by reference to Exhibit 10.20 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.21‡ |  | Rules Governing the Free Share Plan - December 2014 (incorporated by reference to Exhibit 10.21 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                                                            
|       |  |                                                                                                                                                                                                                                                                                                                                                                                                                          
|10.22‡ |  | Rules Governing the Free Share Plan - December 2014 (incorporated by reference to Exhibit 10.22 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                                                                                                            





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|10.23‡ |  | June 2015 Stock Warrant Rules (incorporated by reference to Exhibit 10.23 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                   
|------ |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|       |  |                                                                                                                                                                                                                                                                                                           
|10.24‡ |  | Subscription Form of Stock Warrant (incorporated by reference to Exhibit 10.24 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                           
|10.25‡ |  | December 2015 Stock Option Rules (incorporated by reference to Exhibit 10.25 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                                
|       |  |                                                                                                                                                                                                                                                                                                           
|10.26‡ |  | Form of Stock Option Grant Letter (incorporated by reference to Exhibit 10.26 to the registrant’s Annual Report on Form 10-K for the year ended December 31, 2015, filed on March 15, 2016)                                                                                                               
|       |  |                                                                                                                                                                                                                                                                                                           
|10.27  |  | Common Draft Terms of Cross-Border Merger dated as of June 29, 2016 between Flamel Technologies S.A. and Avadel Pharmaceuticals Limited (subsequently renamed Avadel Pharmaceuticals plc) (incorporated by reference to Exhibit 2.1 to the registrant’s current report on Form 8-K, filed on July 1, 2016)
|       |  |                                                                                                                                                                                                                                                                                                           
|10.28‡ |  | Rules Governing the Free Share Plan - August 2016 (incorporated by reference to Exhibit 99.1 to the registrant’s Registration Statement (No. 333-213154) on Form S-8, filed on August 16, 2016)                                                                                                           
|       |  |                                                                                                                                                                                                                                                                                                           
|10.29‡ |  | August 2016 Stock Option Rules (incorporated by reference to Exhibit 99.2 to the registrant’s Registration Statement (No. 333-213154) on Form S-8, filed on August 16, 2016)                                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                           
|10.30‡ |  | August 2016 Stock Warrant Rules (incorporated by reference to Exhibit 99.3 to the registrant’s Registration Statement (No. 333-213154) on Form S-8, filed on August 16, 2016)                                                                                                                             
|       |  |                                                                                                                                                                                                                                                                                                           
|10.31‡ |  | Form of stock option grant letter for 2016 Stock Option Rules (incorporated by reference to Exhibit 10.31 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2016, filed on March 28, 2017)                                                                                   
|       |  |                                                                                                                                                                                                                                                                                                           
|10.32‡ |  | Employment Agreement by and between Avadel Pharmaceuticals plc and Gregory J. Divis, dated January 4, 2017 (incorporated by reference to Exhibit 10.32 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2016, filed on March 28, 2017)                                      
|       |  |                                                                                                                                                                                                                                                                                                           
|10.33‡ |  | Employment Agreement by and between Avadel Management Corporation and Michael S. Anderson dated August 15, 2017 (incorporated by reference to Exhibit 10.1 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                         
|       |  |                                                                                                                                                                                                                                                                                                           
|10.34‡ |  | Employment Agreement by and between Avadel Management Corporation and Gregory J. Divis dated September 5, 2017 (incorporated by reference to Exhibit 10.2 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                          
|       |  |                                                                                                                                                                                                                                                                                                           
|10.35‡ |  | Employment Agreement by and between Avadel Management Corporation and Sandra Hatten dated August 15, 2017 (incorporated by reference to Exhibit 10.3 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                               
|       |  |                                                                                                                                                                                                                                                                                                           
|10.36‡ |  | Employment Agreement by and between Avadel Management Corporation and Michael F. Kanan dated September 5, 2017 (incorporated by reference to Exhibit 10.4 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                          
|       |  |                                                                                                                                                                                                                                                                                                           
|10.37‡ |  | Employment Agreement by and between Avadel Management Corporation and Phillandas T. Thompson dated August 15, 2017 (incorporated by reference to Exhibit 10.5 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                      





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|10.38* |  | Exclusive Right of Negotiation Agreement by and between Avadel Specialty Pharmaceuticals, LLC and Serenity Pharmaceuticals, LLC dated as of August 11, 2017 (incorporated by reference to Exhibit 10.6 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                              
|------ |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.39* |  | Exclusive License and Assignments Agreement by and between Avadel Specialty Pharmaceuticals, LLC and Serenity Pharmaceuticals, LLC dated as of September 1, 2017 (incorporated by reference to Exhibit 10.7 to the registrant's Quarterly Report on Form 10-Q/A for the quarter ended September 30, 2017, filed on November 17, 2017)                                                      
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.40* |  | Manufacturing Agreement by and between Renaissance Lakewood, LLC (formerly DPT Lakewood, LLC) and Serenity Pharmaceuticals, LLC dated as of July 14, 2014 (incorporated by reference to Exhibit 10.8A to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                               
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.41  |  | Renaissance Agreements Assignment and Assumption Agreement by and between Avadel Specialty Pharmaceuticals, LLC and Serenity Pharmaceuticals, LLC dated as of September 1, 2017 (incorporated by reference to Exhibit 10.8B to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                         
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.42  |  | Master Manufacturing Services Agreement by and between Patheon UK Limited and Éclat Pharmaceuticals L.L.C. dated as of November 8, 2012 (incorporated by reference to Exhibit 10.9 to the registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, filed on November 9, 2017)                                                                                  
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.43* |  | Asset Purchase Agreement by and among Cerecor, Inc. and Avadel Pharmaceuticals (USA), Inc., Avadel Pediatrics, Inc., FSC Therapeutics, LLC, Avadel US Holdings, Inc. and Avadel Pharmaceuticals plc dated as of February 12, 2018 (incorporated by reference to Exhibit 10.43 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.44* |  | License and Development Agreement by and between Cerecor, Inc. and Flamel Ireland Limited operating under the trade name of Avadel Ireland dated as of February 16, 2018 (filed herewith)                                                                                                                                                                                                  
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.45* |  | Guarantee by Avadel US Holdings, Inc. and Avadel Pharmaceuticals plc in favor of Deerfield CSF, LLC, Peter Steelman and James Flynn dated as of February 16, 2018 (incorporated by reference to Exhibit 10.45 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                                                
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|10.46* |  | Guarantee by Armistice Capital Master Fund, Ltd. in favor of Avadel US Holdings, Inc. dated as of February 16, 2018 (incorporated by reference to Exhibit 10.46 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|14.1   |  | Code of Business Conduct and Ethics (incorporated by reference to Exhibit 14.1 to the registrant’s current report on Form 8-K, filed on March 7, 2017)                                                                                                                                                                                                                                     
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|14.2   |  | Financial Integrity Policy (incorporated by reference to Exhibit 14.2 to the registrant’s current report on Form 8-K, filed on March 7, 2017)                                                                                                                                                                                                                                              
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|21.1   |  | List of Subsidiaries (incorporated by reference to
Exhibit  21.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16,
2018)                                                                                                                                                                                                             
|       |  |                                                                                                                                                                                                                                                                                                                                                                                            
|23.1   |  | Consent of PricewaterhouseCoopers Audit (incorporated by reference to Exhibit 23.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                                                                                                                                                                           





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|23.2 |  | Consent of Deloitte & Touche, LLP (incorporated by reference to Exhibit 23.2 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)                                                                                                                                                         
|---- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|     |  |                                                                                                                                                                                                                                                                                                                                                    
|31.1 |  | Certification of the Chief Executive Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 31.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)    
|     |  |                                                                                                                                                                                                                                                                                                                                                    
|31.2 |  | Certification of the Principal Financial Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 31.2 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018)
|     |  |                                                                                                                                                                                                                                                                                                                                                    
|31.3 |  | Certification of the Chief Executive Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith)                                                                                                                                            
|     |  |                                                                                                                                                                                                                                                                                                                                                    
|31.4 |  | Certification of the Principal Financial Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith)                                                                                                                                        
|     |  |                                                                                                                                                                                                                                                                                                                                                    
|32.1 |  | Certification of the Chief Executive Officer pursuant to USC Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 32.1 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018) (1)                                       
|     |  |                                                                                                                                                                                                                                                                                                                                                    
|32.2 |  | Certification of the Principal Financial Officer pursuant to USC Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 32.2 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2017, filed on March 16, 2018) (1)                                   
|     |  |                                                                                                                                                                                                                                                                                                                                                    
|101  |  | Interactive Data Files (2)                                                                                                                                                                                                                                                                                                                         



*Confidential treatment has been
requested for the redacted portions of this agreement. A complete copy of the agreement, including the redacted portions, has been
filed separately with the Securities and Exchange Commission.



‡Management contract or
compensatory plan or arrangement filed pursuant to Item 15(b) of Form 10-K.



(1) This certification accompanies the
Original Form 10-K to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated
by reference into any filing of the registrant under the Securities Act of 1933 or the Securities Exchange Act of 1934 (whether
made before or after the date of the Original Form 10-K, irrespective of any general incorporation language contained in such
filing.



(2) Previously filed or furnished, as applicable,
as an exhibit to the Original Form 10-K.



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