### Di c r oto phos Dietar y Ex p osure and Ri s k A ssess m e nt DP No: D4 2 8508



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, 

### D.C. 20460

OFFICE OF C HEMI CA L SAFETY AND

POLL UTIO N PRE V EN TIO N



### MEMORANDUM

Date: September 1 5, 20 1 5



### S U BJECT: Dicrotophos: Re v ised Acute and Steady State Aggrega t e Di etary (F ood and

Drinkin g Water) Ex po s ur e a nd Ri s k A ssess ment s to S upport R eg i s tration R ev i e w

P C Co d e: 03520 I

Deci s i o n No .: 454409

Petition No.: NA DP B a r co de: 0428508

R eg i s t r atio n No.: NA

R eg ul ator y Act i o n: R egist ration R ev i e w

Case No.: 0 145 Ri s k A ssess m e n t T y p e : Dietary

TXR No.: NA CAS No. : 1 4 1-66- 2

MRID No. : NA



### FROM:

THROUGH:



### TO: Thur ston Morton

, C h emist

# ~r;:/;/ Ri sk Assessm e nt Branch I V

H ea lth Effec t s Di v i s ion (7509 P )

S h e il a Pip er, C h e mist 

# cS i Jc.__.

# ~~ Juli e VanAlstin e, C h em i s t**~·** 

### Di e t a r y Exposu r e Science Adv i so r y Counci l

# harl**e~ ~ith** **,** Branch C hi ef 

# C**~** Ri s k Assessme nt Branch l V

, HED (7509P)

Khue Nguyen

Risk Managem e nt an d Impl e m e ntation Branch l

P es ti c ide Re- eva l uation Di v i s ion (7508 P)



### Exec uti ve S umm ary

Acu t e and stea dy s tat e aggrega t e di e t ary food a n d drinkin g wa ter ex p os ur e and ri s k assessment s
for dicrotophos we r e conducted u s in g th e D i e tar y Expo s ur e Ev aluati o n Mode l software with t h e

Food Co mmodit y Int a ke Databa se ( D EEM-FC ID ) Ver s i o n 3.16. Th i s so ftware u ses 2003

- 2008

food co n su mpti on data from th e U.S. D epartment of Ag riculture ' s (US DA 's) Nationa l H ealt h

and N utrition Ex aminat i on Survey, What We Eat in Am e rica

, (N HAN ES ! WWEIA). Thi s
di etary a n alysi s i s updated t o r e fl ec t th e u se o f th e 2 -d ay average opt i o n in D EE M fo r the s tead y

s tat e di e tary asse ss m e n t. In 

### a ddition

, the FQPA safety fac t or (1 

### OX) w ill be r e tain e d for infant s

, chi ldr e n, yo uth s

, and wo men of c hild-bearin g age fo r th ese ex po s ur e sce nario s t o acco unt for

Pa ge I of28

### uncertainties introdu ced by the lack of suffic i e nt data to quantify potential neurodevelopmental

effects.

Thi s m emorandum was reviewed by two peer r ev i ewers of th e DE SAC per the c urr e n t D ESAC

Standard Operating Proc e dur e (SOP).

Acu t e Di etary (Food a nd Drinking Water) Exposure Results and Characterization

Dicrotophos is a broad spectrum organophosphate i nsectic i de

. T h e only dicrotophos en d-u se

form ul at i on curre ntl y r eg i stered i s a water -mi scib l e formula tion whic h may be fo li arly applied to

establis h ed cotton plants or u sed as a tree injection treat m ent for ornamental and non

- food producing trees.

A refined ac ut e dietary exposure assessment was conducted to es timat e the dietary e xpo s u re and

ri sk associated w ith r eg i strat i on review. Th e acute d i etary expos ur e assessment incorporated

average field trial r es idu e, 100% cro p treated

, and the entire distribution of est im ated drinking

water concentrat i o n s (E DW Cs) for th e acute analysis. The drinking water concentrat ion s were

based on the u se of d i crotophos from three cotton scenar io s.

The ac u te agg r ega t e di etary expos ur e estimates are below HED 's l eve l of concern ( < l 00 % the

acute popu l at i o n a dju sted dose (aP A D )) for the U

. S

. population and all popu l ation subgro up s for

a ll but one water scenar i o (NC Cotton Max R ate). Com bin ed di etary exposure from food and
drinking water at the 95' 11 

### percentile of exposure ranged from 11-50% of the aPAD for th e U.S.
population and 1 9-130% of the aPAD for all infants < 1 year old)

, the most highly exposed
population s ub g r o up. The di etary expos ur e est im ates for food o nl y were :5 11 % aPA D fo r all
population s u bgro u ps.

Two-Day Average Di etary (Food and D rinking Water) Exposure R es ult s and C har acter i zation

OPs may exh i bit a phenomenon known as steady-state acetylcholinesterase (AChE) inhibition

,

w hi ch is the most sensi ti ve e ndp oint for all lifestages

. After r epeate d do s in g at th e same dose

, the amount of AChE inhibi t i on in a g iv e n dose remains cons i stent ac ro ss duration. For this

reason

, a steady-state point of departure (POD) was se l ected for ora l exposure to dicrotophos

.

Th e D EEM ac u te modul e was used to co ndu ct r efined two-day (steady-sta t e) average

assess m e n ts using the steady-s tat e endpoint and 2 1-d ay forward-rolli n g wate r averages

. Th ese two-day average assessments es tim ate 21-day ("s t eady

- state") average daily food and drinking

water exposures. T h e sa m e drinking water sce n ar i os were pro v id ed by EFED for use in t he twoday average ana l yses. The drinking water di st ribu t i ons provided by E F ED we r e converted int o

distributions of 2 1-da y forwar d-rollin g averages for the two-day average assessme nt s. A

discussion of how the 2 1-da y fo r ward-ro llin g averages were calcu l a t e d ca n be found in Sect i o n V

.



### The food only steady-state r esu lt s do not exceed HED 's LOC (<100% of th e steady-state

pop ul ation

- adjusted dose (ss P A D )) for th e U

. S

. population a nd a ll population s ub gro u ps at t h e

95 111 

### pe rc enti l e. The U

. S

. pop ulation utilized 10% of the ss PAD and chi l dren 3-5 years o ld

, the

Page 2 of28Page 3 of 28



### most highly expose d population subgroup, utilized 23 % of the ssPAD. For the two

- day

average

The steady state (2 day average) aggregate dietary (food and drinking water) exposure estimates using DEEM

- FCID with the 2

- day average option are above HED’s level of concern for all maximum application rate cotton water scenarios. Combined dietary exposure from food and drinking water at the 95 th 

### percentile of exposure ranged from 10

- 52 % of the ss PAD for the U.S. population and 50

- 32 0% of the ss PAD for all infants <1 y ea r ol d). All typical application rate (as determined by BEAD) cotton scenarios gave aggregate dietary (food and drinking water) exposure estimates <100% ssPAD. The dietary exposure estimates for food only were ≤ 23% ssPAD for all population subgroups.

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

D icrotophos is classified as showing "Suggestive evidence of carcinogenicity, but not sufficient to assess human carcinogenic potential”. Quantitative risk assessment for dicrotop hos using the Reference Dose (RfD) approach will adequately account for all chronic toxic effects, incl uding carcinogenicity

.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For the

acute and two

- day average assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the PAD. The PAD is equivalent to t he point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and two

- day average assessments, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss dietary risk a ssessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from
Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.epa.gov/fedrgstr/EPA

PEST/2000/July/Day

- 12/6061.pdf; or see SOP 99.6 (20

- AUG

- 1999).

The two

- day average assessments were conducted in the DEEM acute module using the steady

state endpoint and 21

- day forward

- rolling water averages to provide an estimate of 21

- day (“steady

- state”) average daily exposures. These two

- day aver age assessments were completed for food alone and food and drinking water. For the two

- day average assessments, using a 21

- day forward

- rolling average water file, provide an accurate overall estimate of the 21

- day (“steady

- state”) average daily exposures at the per

- capita 95 th 

### percentile for drinking water, to the extent that predicted drinking water concentrations for any 21

- day duration is known for any given year. For food alone, the two

- day average assessments reflect an average daily exposure

for a t wo

- day exposure duration rather than a 21

- day exposure duration. Since the DEEM two

day average assessment does not capture day

- to

- day variation in food residues, it will generally result in higher food

- only exposure estimates than a model that calculates 21

- day rolling averages for food. Although the DEEM two

- day average assessments may result in higher exposure estimates for food, the assessments provide a reasonable estimate of 21

- day (“steady

-Page 4 of 28



### state”) average daily exposure for food and drinking water for use in risk assessment.

The most recent dietary risk assessment for dicrotophos was conducted by T

. Morton ( July 1 0,

20 14 , D 41 8 10 3 ).

II. Residue Information

Dicrotophos (dimethyl phosphate of 3

- hydroxy

- N,N

- dimethyl

- cis

- crotonamide) is a contact, systemic acaricide/insecticide registered for use on cotton. Permanent tolerances are established

for the residues of dicrotophos and monocrotophos at 0.20 ppm in cotton, undelinted seed and at

2.0 ppm in cotton gin byproducts (40CFR §180. 299 ).

The residues of concern in plants are dicrotophos and monocrotophos

.

Residue Data used for Acute and Steady state Dietary Assessments

A refined acute dietary exposure assessment was conducted using average field trial residue s and 100% crop treated

.

The USDA Pesticide Data Program (PDP) monitored for dicrotophos pesticide residues in catfish in 2008. PDP analyzed 552 samples of catfish for dicrotophos residues. None of the samples
contained detectable residues. As a result, residues in fish were n ot included in the assessment.

I I I. Percent Crop Treated Information

The acute and steady state aggregate dietary analyses were per formed assuming 100% of each commodity was treated with dicrotophos

.

IV. Drinking Water Data

This assessment uses maximum rates but considers typical rates. The assessment considers a parent only approach but also considers the major degradates as parent in a total toxic residue (TTR) approach. Toxicity data and acceptable environmental fate data is unavailable for dicrotop hos degradates. Inclusion of the TTR approach is provided for a complete

characterization of EDWCs.

Daily time series outputs for the thirty year simulation were provided to HED for use in dietary exposure modeling (A. Shelby, D427440, 8/13/15)

.Page 5 of 28



### Table 5.3. Summary of Estimated Surface Water and Groundwater Concentrations for Dicrotophos.

SWCC

Scenario Application rate

and timing 1

- in

- 10

- year

peak (ppb) 1

- in

- 10

- year 21

day average (ppb) 1

- in

- 10

- year

annual average (ppb) Simulation

average (ppb)
Mississippi

Cotton Maximum Rate 6.09 4.01 0.381 0.199

Typical Rate

- BEAD dates 3.21 1.67 0.193 0.0860

Typical Rate

- 14 day interval 4.49 2.45 0.204 0.0834

North

Carolina

Cotton Maximum Rate 7.73 4.94 0.507 0.306

Typical Rate 1.62 1.05 0.0901 0.0503

Texas

Cotton Maximum Rate 8.75 4.63 0.430 0.222

Typical Rate

- BEAD dates 3.66 2.12 0.238 0.0934

Typical Rate

- 14 day interval 3.69 2.09 0.217 0.0839



### V. DEEM

- FCID Program and Consumption Information

A dicrotophos acute and steady state (2

- day average) dietary exposure assessment w as conducted using the DEEM

- FCID, Version 3.16 , which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than

20,000 indivi duals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie)

are linked to EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S;
baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups . However , for

acute exposure assessment

, consumption data are re tained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subg roups: the general U.S. population, all infants (<1 year old), children

1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For an acute exposure assessment, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in mult iple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating
relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for a nalyses performed at all levels of refinement . However, for

dete rministic assessments , any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.Page 6 of 28



### For the steady

- state (acute 2

- day average) exposure assessment, 2

- day average food consumptions are c alculated on an individual

- by

- individual basis. The reported consumption amounts of each food item for each day are added together and then divided by two (2) days. For example, if an individual reports eating 100 grams of apple on the first day and 0 gr ams of apple on the second day, the 2

- day average consumption amount would be 50 grams/day of apple [(100 grams + 0 grams)/2

- days = 50 grams/day]. The resulting 2

- day average consumption amount can then be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a perc entage of the PAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

VI. Toxicological Information

Dicrotophos is a member of the organophosphate (OP) class of pesticides. Like other OPs , the initiating event in the adverse outcome pathway (AOP), also often called the mode of action (MOA), for dicrotophos involves inhi bition of the enzyme acetylcholinesterase (AChE) via phosphorylation of the serine residue at the active site of the enzyme. This inhibition leads to accumulation of acetylcholine and ultimately to neurotoxicity in the central and/or peripheral

nervous sy stem . For dicrotophos, AChE inhibition is the most sensitive endpoint in the toxicology database in multiple species, durations, lifestages, and routes . AChE inhibition is the

focus of this hazard characterization ; t he availability of reliable AChE inhibition dose response data is one of the key determinants in evaluating the toxicology database. Some OPs require
metabolic activation to the oxon metabolite. However, dicrotophos is not one of these OPs. Instead, dicrotophos as the parent active ingredient is a ChE

- inhibiting chemical.

In general, OPs reach steady state within 2

- 3 weeks but this can vary among OPs. In the case of dicrotophos , the results show a clear pattern of steady state reached at or near 1 5 days of

exposure. In addition to the consistency across durations, the data across multiple studies (repeat CCA study, gestational data from the DNT, subchronic neurotoxicity study, and subchronic rat toxicity study) are similar. Although the durations of the toxicity and exposure as sessments may differ, an exact match is not necessary and would suggest a level of precision that the toxicity data do not support. Furthermore, humans would be expected to be slower and closer to the typical 2

- 3 week window of duration. Given this, the 21

- day and longer exposure assessment is scientifically supportable and also provides consistency across the OPs. Given the results in

Table 3 , for dicrotophos , acute (single day) and steady state durations are appropriate for human

health risk assessment

.

HED’s ToxSAC met ( 07/18/2013 ) to consider the endpoints of toxicological concern for the dietary exposure

. The FQPA 10X Safety Factor will be retained for infants, children, youths, and women of childbearing age for all exposure scenarios. Therefore, the dietary exposure results for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5,Page 7 of 28



### children 6

- 12, youth 13

- 19, females 13

- 49, and adults 20

- 49 will include an 10x FQPA SF with the exception of adults 50

- 99 years (T. Mort on, D428506, 9/15/15)

.

Table 3. Summary of Toxicological Doses and Endpoints for Dicrotophos for use in Human Health

Risk Assessments

. Exposure/

Scenario Point of

Departure Uncertainty/

FQPA Safety

Factors RfD, PAD, Level

of Concern for

Risk Assessment Study and Toxicological

Effects

Acute Dietary (all populations, including

females 13

- 49 except for Adults

50

- 99 ) BMDL 10 =

0.07mg/kg/day UF A = 10x

UF H = 10x
FQPA SF =

1 0 x Acute PAD =

0.00 0 07 mg/kg/day CCA Study (MRID 4615205)

in the rat

– PND 8, 15, & 22

Inhibition of brain ChE in male and female rat pups.

Acute Dietary
( Adults 50

- 99 ) BMDL 10 =

0.07mg/kg/day UF A = 10x

UF H = 10x
FQPA SF =

1x Acute PAD =

0.0 0 07 mg/kg/day CCA Study (MRID 4615205)

in the rat

– PND 8, 15, & 22

Inhibition of brain ChE in male and female rat pups.

Steady

- State Dietary (all populations except for Adults

50

- 99 ) BMDL 10 =

0.03 mg/kg/day UF A = 10x

UF H = 10x
FQPA SF =

1 0 x Steady State PAD

= 0.00 0 03 mg/kg/day Subchronic and chronic

toxicity studies (OP CRA
2002, 2006; MRID’s

43980201 and 44527802)

Inhibition of brain ChE in

adult rat

Steady

- State Dietary ( adults

50

- 99 ) BMDL 10 =

0.03 mg/kg/day UF A = 10x

UF H = 10x
FQPA SF =

1x Steady State PAD

= 0.0003 mg/kg/day Subchronic and chronic

toxicity studies (OP CRA
2002, 2006; MRID’s

43980201 and 44527802)

Inhibition of brain ChE in

adult rat

Cancer (oral,
dermal,
inhalation) Classification: "Suggestive evidence of carcinogenicity, but not sufficient to assess

human carcinogenic potential ”

.
Point of Departure (PoD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human

exposures. BMDL 10 = bench mark dose lower limit for 10% response. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. RfD = reference dose.



### VII. Results/Discussion

As stated above, for acute and steady state assessments, HED are concerned when dietary risk

exceeds 100% of the PAD. The DEEM

- FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in t able s below are for thePage 8 of 28



### general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth

13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

The acute aggregate dietary exposure estimates are below HED’s level of concern (<100 % the

a cute population adjusted dose ( aPAD ) ) for the U.S. population and all population subgroups for

all but one water scenario (NC Cotton Max Rate) . Combined dietary exposure from food and drinking water at the 95 th 

### percentile of exposure ranged from 11

- 50 % of the aPAD for the U.S. population and 19

- 130% of the aPAD for all infants <1 y ea r old), the most highly exposed population subgroup. The dietary exposure estimates for food only were ≤ 11% aPAD for all populat ion subgroups.

The steady state (2 day average) aggregate dietary (food and drinking water) exposure estimates using DEEM

- FCID with the 2

- day average option are above HED’s level of concern for all maximum application rate cotton water scenarios

. Combined dietary exposure from food and drinking water at the 95 th 

### percentile of exposure ranged from 10

- 5 2 % of the ss PAD for the U.S. population and 50

- 3 2 0% of the ss PAD for all infants <1 y ea r old). All typical application rate (as determined by BEAD) c otton scenarios gave aggregate dietary (food and drinking water) exposure estimates <100% ssPAD. The dietary exposure estimates for food only were ≤ 23% ssPAD for all population subgroups.

Acute Dietary Exposure Analyses

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food Only )

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 04 5.7

All Infants (< 1 year old) 0.0 0 007 0.000002 2.6

Children 1

- 2 years old 0.0 0 007 0.000008 11

Children 3

- 5 years old 0.0 0 007 0.0000 08 11

Children 6

- 12 years old 0.0 0 007 0.0000 06 8.2

Youth 13

- 19 years old 0.0 0 007 0.0000 04 5.1

Adults 20

- 49 years old 0.0 0 007 0.0000 02 3.4

Adults 50

- 99 years old 0.0 0 07 0.0000 02 <1

Females 13

- 49 years old 0.0 0 007 0.0000 02 3.5

* The values for the highest exposed population is bolded.Page 9 of 28

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Typical Rate

– BEAD Date

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 11 15

All Infants (< 1 year old) 0.0 0 007 0.00002 4 35

Children 1

- 2 years old 0.0 0 007 0.0000 17 25

Children 3

- 5 years old 0.0 0 007 0.0000 16 23

Children 6

- 12 years old 0.0 0 007 0.0000 12 17

Youth 13

- 19 years old 0.0 0 007 0.0000 09 12

Adults 20

- 49 years old 0.0 0 007 0.0000 1 0 15

Adults 50

- 99 years old 0.0 0 07 0.0000 1 0 1.4

Females 13

- 49 years old 0.0 0 007 0.0000 1 0 14

* The values for the highest exposed population is bolded.

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Typical Rate

– 14 DI

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 10 14

All Infants (< 1 year old) 0.0 0 007 0.0000 20 29

Children 1

- 2 years old 0.0 0 007 0.0000 16 23

Children 3

- 5 years old 0.0 0 007 0.0000 15 21

Children 6

- 12 years old 0.0 0 007 0.0000 11 16

Youth 13

- 19 years old 0.0 0 007 0.0000 08 11

Adults 20

- 49 years old 0.0 0 007 0.0000 09 13

Adults 50

- 99 years old 0.0 0 07 0.0000 09 1.3

Females 13

- 49 years old 0.0 0 007 0.0000 09 13

* The values for the highest exposed population is bolded.Page 10 of 28

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Max Rate

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 2 0 29

All Infants (< 1 year old) 0.0 0 007 0.0000 49 70

Children 1

- 2 years old 0.0 0 007 0.0000 30 43

Children 3

- 5 years old 0.0 0 007 0.0000 27 38

Children 6

- 12 years old 0.0 0 007 0.0000 19 28

Youth 13

- 19 years old 0.0 0 007 0.0000 15 22

Adults 20

- 49 years old 0.0 0 007 0.0000 20 28

Adults 50

- 99 years old 0.0 0 07 0.0000 19 2.8

Females 13

- 49 years old 0.0 0 007 0.0000 2 0 28

* The values for the highest exposed population is bolded.

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Typical Rate

– BEAD Date

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 10 15

All Infants (< 1 year old) 0.0 0 007 0.00002 3 3 2

Children 1

- 2 years old 0.0 0 007 0.0000 17 24

Children 3

- 5 years old 0.0 0 007 0.0000 16 23

Children 6

- 12 years old 0.0 0 007 0.0000 12 17

Youth 13

- 19 years old 0.0 0 007 0.0000 08 12

Adults 20

- 49 years old 0.0 0 007 0.0000 10 14

Adults 50

- 99 years old 0.0 0 07 0.0000 09 1.3

Females 13

- 49 years old 0.0 0 007 0.0000 10 14

* The values for the highest exposed population is bolded.Page 11 of 28

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Typical Rate

– 14 DI

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 10 14

All Infants (< 1 year old) 0.0 0 007 0.0000 21 30

Children 1

- 2 years old 0.0 0 007 0.0000 16 23

Children 3

- 5 years old 0.0 0 007 0.0000 15 21

Children 6

- 12 years old 0.0 0 007 0.0000 11 16

Youth 13

- 19 years old 0.0 0 007 0.0000 08 11

Adults 20

- 49 years old 0.0 0 007 0.0000 09 13

Adults 50

- 99 years old 0.0 0 07 0.0000 09 1.2

Females 13

- 49 years old 0.0 0 007 0.0000 09 13

* The values for the highest exposed population is bolded.

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Max Rate

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 22 31

All Infants (< 1 year old) 0.0 0 007 0.00005 3 76

Children 1

- 2 years old 0.0 0 007 0.0000 33 47

Children 3

- 5 years old 0.0 0 007 0.0000 29 41

Children 6

- 12 years old 0.0 0 007 0.0000 21 30

Youth 13

- 19 years old 0.0 0 007 0.0000 16 24

Adults 20

- 49 years old 0.0 0 007 0.0000 21 30

Adults 50

- 99 years old 0.0 0 07 0.0000 21 3.0

Females 13

- 49 years old 0.0 0 007 0.0000 21 30

* The values for the highest exposed population is bolded.Page 12 of 28

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) NC Cotton Typical Rate

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 08 11

All Infants (< 1 year old) 0.0 0 007 0.0000 13 19

Children 1

- 2 years old 0.0 0 007 0.0000 13 18

Children 3

- 5 years old 0.0 0 007 0.0000 12 18

Children 6

- 12 years old 0.0 0 007 0.0000 0 9 13

Youth 13

- 19 years old 0.0 0 007 0.0000 06 9.2

Adults 20

- 49 years old 0.0 0 007 0.0000 07 9.9

Adults 50

- 99 years old 0.0 0 07 0.0000 06 <1

Females 13

- 49 years old 0.0 0 007 0.0000 07 9.7

* The values for the highest exposed population is bolded.

Results of Acute Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) NC Cotton Max Rate

Population Subgroup aPAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 007 0.0000 35 50

All Infants (< 1 year old) 0.0 0 007 0.0000 9 2 130

Children 1

- 2 years old 0.0 0 007 0.0000 52 75

Children 3

- 5 years old 0.0 0 007 0.0000 46 66

Children 6

- 12 years old 0.0 0 007 0.0000 33 48

Youth 13

- 19 years old 0.0 0 007 0.0000 26 38

Adults 20

- 49 years old 0.0 0 007 0.0000 35 50

Adults 50

- 99 years old 0.0 0 07 0.0000 35 5.0

Females 13

- 49 years old 0.0 0 007 0.0000 35 50

* The values for the highest exposed population is bolded.Page 13 of 28



### Steady State Dietary Exposure Analyses

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food Only)

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.0000 03 10

All Infants (< 1 year old) 0.0 0 00 3 0.0000 02 5.9

Children 1

- 2 years old 0.0 0 00 3 0.0000 07 22

Children 3

- 5 years old 0.0 0 00 3 0.0000 07 23

Children 6

- 12 years old 0.0 0 00 3 0.0000 05 17

Youth 13

- 19 years old 0.0 0 00 3 0.0000 03 11

Adults 20

- 49 years old 0.0 0 00 3 0.0000 02 7.3

Adults 50

- 99 years old 0.0 0 0 3 0.0000 02 <1

Females 13

- 49 years old 0.0 0 00 3 0.0000 02 7.5

* The values for the highest exposed population is bolded.

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Typical Rate

– BEAD Date

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.0000 11 16

All Infants (< 1 year old) 0.0 0 00 3 0.0000 25 83

Children 1

- 2 years old 0.0 0 00 3 0.0000 17 58

Children 3

- 5 years old 0.0 0 00 3 0.0000 16 52

Children 6

- 12 years old 0.0 0 00 3 0.0000 12 39

Youth 13

- 19 years old 0.0 0 00 3 0.0000 09 29

Adults 20

- 49 years old 0.0 0 00 3 0.0000 10 35

Adults 50

- 99 years old 0.0 0 0 3 0.000 010 3.3

Females 13

- 49 years old 0.0 0 00 3 0.0000 10 34

* The values for the highest exposed population is bolded.Page 14 of 28

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Typical Rate

– 14 DI

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.0000 1 0 14

All Infants (< 1 year old) 0.0 0 00 3 0.0000 22 72

Children 1

- 2 years old 0.0 0 00 3 0.0000 16 53

Children 3

- 5 years old 0.0 0 00 3 0.0000 15 48

Children 6

- 12 years old 0.0 0 00 3 0.0000 11 36

Youth 13

- 19 years old 0.0 0 00 3 0.0000 0 8 27

Adults 20

- 49 years old 0.0 0 00 3 0.0000 1 0 32

Adults 50

- 99 years old 0.0 0 0 3 0.0000 09 3.0

Females 13

- 49 years old 0.0 0 00 3 0.0000 09 31

* The values for the highest exposed population is bolded.

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) MS Cotton Max

Rate

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.000 021 30

All Infants (< 1 year old) 0.0 0 00 3 0.00005 3 180

Children 1

- 2 years old 0.0 0 00 3 0.0000 32 110

Children 3

- 5 years old 0.0 0 00 3 0.0000 28 94

Children 6

- 12 years old 0.0 0 00 3 0.0000 20 68

Youth 13

- 19 years old 0.0 0 00 3 0.0000 16 53

Adults 20

- 49 years old 0.0 0 00 3 0.0000 21 68

Adults 50

- 99 years old 0.0 0 0 3 0.0000 20 6.6

Females 13

- 49 years old 0.0 0 00 3 0.000 020 68

* The values for the highest exposed population is bolded.Page 15 of 28

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Typical Rate

– BEAD Date

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.0000 1 1 15

All Infants (< 1 year old) 0.0 0 00 3 0.0000 23 78

Children 1

- 2 years old 0.0 0 00 3 0.0000 17 56

Children 3

- 5 years old 0.0 0 00 3 0.0000 15 51

Children 6

- 12 years old 0.0 0 00 3 0.0000 11 38

Youth 13

- 19 years old 0.0 0 00 3 0.0000 08 28

Adults 20

- 49 years old 0.0 0 00 3 0.0000 10 33

Adults 50

- 99 years old 0.0 0 0 3 0.0000 09 3.2

Females 13

- 49 years old 0.0 0 00 3 0.0000 10 33

* The values for the highest exposed population is bolded.

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Typical Rate

– 14 DI

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.0000 1 0 14

All Infants (< 1 year old) 0.0 0 00 3 0.0000 22 74

Children 1

- 2 years old 0.0 0 00 3 0.0000 16 53

Children 3

- 5 years old 0.0 0 00 3 0.0000 15 49

Children 6

- 12 years old 0.0 0 00 3 0.0000 11 36

Youth 13

- 19 years old 0.0 0 00 3 0.0000 0 8 27

Adults 20

- 49 years old 0.0 0 00 3 0.0000 1 0 32

Adults 50

- 99 years old 0.0 0 0 3 0.0000 09 3.0

Females 13

- 49 years old 0.0 0 00 3 0.0000 09 31

* The values for the highest exposed population is bolded.Page 16 of 28

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) TX Cotton Max

Rate

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.0000 22 32

All Infants (< 1 year old) 0.0 0 00 3 0.0000 57 190

Children 1

- 2 years old 0.0 0 00 3 0.0000 34 110

Children 3

- 5 years old 0.0 0 00 3 0.0000 30 100

Children 6

- 12 years old 0.0 0 00 3 0.0000 22 73

Youth 13

- 19 years old 0.0 0 00 3 0.0000 17 57

Adults 20

- 49 years old 0.0 0 00 3 0.0000 22 73

Adults 50

- 99 years old 0.0 0 0 3 0.0000 21 7.1

Females 13

- 49 years old 0.0 0 00 3 0.0000 22 73

* The values for the highest exposed population is bolded.

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) NC Cotton Typical Rate

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.0000 08 11

All Infants (< 1 year old) 0.0 0 00 3 0.0000 15 50

Children 1

- 2 years old 0.0 0 00 3 0.0000 13 43

Children 3

- 5 years old 0.0 0 00 3 0.0000 12 40

Children 6

- 12 years old 0.0 0 00 3 0.0000 09 30

Youth 13

- 19 years old 0.0 0 00 3 0.0000 06 21

Adults 20

- 49 years old 0.0 0 00 3 0.0000 07 24

Adults 50

- 99 years old 0.0 0 0 3 0.0000 07 2.2

Females 13

- 49 years old 0.0 0 00 3 0.0000 07 23

* The values for the highest exposed population is bolded.Page 17 of 28

Results of Steady State Dietary Exposure Analysis for Dicrotophos (Food and Drinking Water) NC Cotton Max

Rate

Population Subgroup ss PAD (mkd) 95 th Percentile

Exposure (mkd) % aPAD

General U.S. Population 0.0 0 00 3 0.000 036 52

All Infants (< 1 year old) 0.0 0 00 3 0.0000 9 7 320

Children 1

- 2 years old 0.0 0 00 3 0.0000 53 180

Children 3

- 5 years old 0.0 0 00 3 0.0000 46 150

Children 6

- 12 years old 0.0 0 00 3 0.0000 33 110

Youth 13

- 19 years old 0.0 0 00 3 0.0000 27 90

Adults 20

- 49 years old 0.0 0 00 3 0.0000 36 120

Adults 50

- 99 years old 0.0 0 0 3 0.0000 36 12

Females 13

- 49 years old 0.0 0 00 3 0.0000 36 120

* The values for the highest exposed population is bolded.



### VIII

. Characterization of Inputs/Outputs

HED has conducted refined acute and steady state dietary risk assessments for dicrotophos

. OPs exhibit a phenomenon known as steady state AChE inhibition and for coumaphos a steady state endpoint was selected. Although

, there are rat data at a shorter time period (i.e., 1 5 days) than 21 days, exposure assessments of 21 days and longer w ere cond ucted for all routes of exposure (i.e., oral, dermal and inhalation) for all single chemical OP assessments usi ng Calendex

. Given this,

the 21

- day and longer exposure assessment is scientifically supportable and also provides consistency across the OPs

.

IX

. Conclusions

Th ese refined analys es demonstrate that the registered uses for dicrotophos will result in acute dietary risk estimates that exceed HED ’s level of concern for one drinking water scenario

. In

addition , the steady state dietary exposure estimates are above HED’s level of concern for the

U.S. population and all population subgroups for all maximum cotton application rate drinking

water scenarios

.

X. List of Attachments

Attachment 1 : Example Acute (Food + Drinking Water) Residue Input File

Attachment 2 : Acute (Food + Drinking Water ) Results File

Attachment 3 : Steady State (Food + Drinking Water) Results FilePage 18 of 28



### Attachment 1 : Example Acute (Food + Drinking Water) Residue Input File

Filename: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 035201 Dicrotophos \ 2013 Working Files

USE THESE \ New Time Series After Amvac Comments 7

- 2015 \ 035201 Acute MScotton

- maxrate

BEADstartdate.R08
Chemical: Dicrotophos RfD(Chronic): .0003 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): .0007 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 08

- 17

- 2015/15:07:51 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

----- ---- ------------ -------- -------- ------- 1 6 DrinkingWaterDicrotophosMScotton

- maxrate

- BEADstartdate.rdf

EPA Crop Commodity Name Def R es Adj.Factors RDLComment Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 2003128000 20C Cottonseed, oil 0.0430 00 1.000 1.000

2003128001 20C Cottonseed, oil

- babyfood 0.043000 1.000 1.000

8601000000 86A Water, direct, all sources 0.012600 1.000 1.000 1

8602000000 86B Water, indirect, all sources 0.012600 1.000 1 .000 1Page 19 of 28



### Attachment 2 : Acute (Food + Drinking Water) Results File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Acute TXcotton

- maxrate

- BEADstartdate .R08
Adjustment factor #2 NOT used.
Analysis Date: 08

- 18

- 2015/06:17:02 Residue file dated: 08

- 17

- 2015/15:09:27

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Populatio n:

0.000022 3.08 0.000074 10.58 0.000289 41.34

All Infants:

0.000053 75.90 0.000205 292.56 0.000903 1289.94

Children 1

- 2:

0.000033 46.94 0.000109 156.22 0. 000436 623.35

Children 3

- 5:

0.000029 41.10 0.000094 133.68 0.000355 506.91

Children 6

- 12:

0.000021 30.08 0.000068 97.31 0.000266 380.34

Youth 13

- 19:

0.000016 23. 51 0.000056 79.97 0.000225 321.01

Adults 20

- 49:

0.000021 30.46 0.000073 104.16 0.000284 406.32

Adults 50

- 99:

0.000021 2.97 0.000071 10.08 0.000267 38.12

Female 13

- 49:

0.000021 30.25 0.000073 103.92 0.000287 409.43

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Acute TXcotton

- typrate

- BEADdate .R08
Adjustment factor #2 NOT used.

Analysis Date: 08

- 18

- 2015/06:35:13 Residue file dated: 08

- 17

- 2015/15:10:02

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intak e summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th P ercentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0. 000010 1.48 0.000033 4.70 0.000110 15.71

All Infants:

0.000023 32.29 0.000088 125.90 0.000328 467.93

Children 1

- 2:

0.000017 24.23 0.000053 75.11 0.000165 236.27

Children 3

- 5:

0.000016 22.58 0.000046 65.85 0.000138 197.71

Children 6

- 12:

0.000012 16.57 0.000035 50.50 0.000103 146.64

Youth 13

- 19:

0.000008 11.84 0.000026 37.47 0.000086 122.87

Adults 20

- 49:

0.000010 14.05 0.000032 45.56 0.000106 151.29

Adults 50

- 99:

0.000009 1.32 0.000030 4.30 0.000099 14.15Page 20 of 28

Female 13

- 49:

0.000010 13.83 0.000031 44.74 0.000107 152.31

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file : 035201 Acute TXcotton

- typrate

- 14DI .R08
Adjustment factor #2 NOT used.
Analysis Date: 08

- 18

- 2015/06:31:02 Residue file dated: 08

- 17

- 2015/15:09:44

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 9 9th Percentile 99.9th Percentile
Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000010 1.40 0.000031 4.46 0.000098 13.98

All Infants:

0.000021 29.69 0.000084 119.98 0.000292 417.22

Children 1

- 2:

0.000016 22.99 0.000051 72.83 0.000148 210.85

Children 3

- 5:

0.000015 21.47 0.000044 62.23 0.000127 181.19

Children 6

- 12:

0.000011 15.77 0.000034 49.05 0.000092 131.52

Youth 13

- 19:

0.000008 11.19 0.000025 35.37 0.00 0077 109.91

Adults 20

- 49:

0.000009 13.22 0.000030 43.03 0.000094 134.09

Adults 50

- 99:

0.000009 1.24 0.000028 4.06 0.000087 12.49

Female 13

- 49:

0.000009 13.00 0.000030 42.16 0.000094 134.97

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Acute NCcotton

- maxrate .R08 Adjustment factor #2 NOT used.

Analysis Date: 08

- 17

- 2015/15:30:58 Residue file dated: 08

- 17

- 2015/15:08:49

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000035 5.04 0.000101 14.44 0.000274 3 9.14

All Infants:

0.000092 131.21 0.000304 433.64 0.000797 1138.63

Children 1

- 2:

0.000052 74.87 0.000151 215.93 0.000415 593.33

Children 3

- 5:

0.000046 65.68 0.0001 27 181.38 0.000334 476.47

Children 6

- 12:Page 21 of 28 0.000033 47.76 0.000093 132.79 0.000251 358.82

Youth 13

- 19:

0.000026 37.66 0.000078 111.64 0.000219 312.84

Adults 20

- 49:

0.000035 50.44 0.000100 142.84 0.000259 369.42

Adults 50

- 99:

0.000035 4.96 0.000094 13.48 0.000239 34.08

Female 13

- 49:

0.000035 50.12 0.000101 143.58 0.000261 372.72

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Acute NCcotton

- typrate .R08 Adjustment factor #2 NOT used.

Analysis Date: 08

- 17

- 2015/15:35:00 Residue file dated: 08

- 17

- 2015/15:09:08

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000008 1.09 0.000023 3.28 0.000068 9.78

All Infants:

0.000013 19.25 0.000061 86.87 0.000193 275.45

Children 1

- 2:

0.000013 18.45 0.000038 54.91 0.000103 146.46

Children 3

- 5:

0.000012 17.67 0.000032 45.69 0.000088 125.34

Children 6

- 12:

0.000009 12.98 0.000026 36.62 0.000065 93.02

Youth 13

- 19:

0.000006 9.17 0.000019 27.80 0.000055 78.40

Adults 20

- 49:

0.000007 9.86 0.000022 31.35 0.000064 91.15

Adults 50

- 99:

0.000006 0.92 0.000020 2.92 0.000059 8.45

Female 13

- 49:

0.000007 9.69 0.000022 31.08 0.00 0064 91.98

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Acute MScotton

- maxrate

- BEADstartdate .R08
Adjustment factor #2 NOT used.

Analysis Date: 08

- 17

- 2015/15:16:39 Residue file dated: 08

- 17

- 2015/15:07:51

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC s eed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Ex posure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000020 2.85 0.000067 9.54 0.000299 42.71

All Infants:

0.000049 69.61 0.000182 259.82 0.000868 1239.35Page 22 of 28

Children 1

- 2:

0.000030 43.30 0.000100 142.33 0.000444 633.97

Children 3

- 5:

0.000027 38.13 0.000084 119.93 0.00 0365 520.83

Children 6

- 12:

0.000019 27.82 0.000061 87.74 0.000269 384.78

Youth 13

- 19:

0.000015 21.65 0.000051 72.74 0.000229 327.44

Adults 20

- 49:

0.000020 28.26 0.000065 93.40 0.000296 422.89

Adults 50

- 99:

0.000019 2.75 0.000063 8.98 0.000279 39.80

Female 13

- 49:

0.000020 28.01 0.000065 93.54 0.000297 424.06

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Acute MScotton

- typrate

- BEADdate .R08
Adjustment factor #2 NOT used.

Analysis Date: 08

- 17

- 2015/15 :26:53 Residue file dated: 08

- 17

- 2015/15:08:30

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aPAD Exposure % aPAD E xposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000011 1.53 0.000032 4.62 0.000100 14.30

All Infants:

0.000024 34.62 0. 000086 123.41 0.000305 435.12

Children 1

- 2:

0.000017 24.90 0.000052 73.98 0.000151 215.09

Children 3

- 5:

0.000016 23.19 0.000045 63.85 0.000131 186.69

Children 6

- 12:

0.000012 16.95 0.000035 49.51 0.000092 131.97

Youth 13

- 19:

0.000009 12.24 0.000026 36.84 0.000079 113.54

Adults 20

- 49:

0.000010 14.68 0.000031 44.62 0.000097 138.00

Adults 50

- 99:

0.000010 1.39 0.000029 4.18 0.000090 12.84

Female 13

- 49:

0.000010 14.47 0.000031 43.82 0.000098 139.43

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Acute MScotton

- typrate

- 14DI .R08
Adjustment factor #2 NOT used.
Analysis Date: 08

- 17

- 2015/15:22:57 Residue file dated: 08

- 17

- 2015/15:0 8:11
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

============================================== =================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aPAD Exposure % aPAD Exposure % aPADPage 23 of 28 ---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000010 1.39 0.000032 4.62 0.000126 17.97

All Infants:

0.000020 29.19 0.000083 119.00 0.000382 545.27

Children 1

- 2:

0.000016 22.72 0.000052 74.31 0.000187 267.74

Children 3

- 5:

0.000015 21.35 0.000046 65.09 0.000156 222.23

Children 6

- 12:

0.000011 15.63 0.000035 49.85 0.000114 163.18

Youth 13

- 19:

0.000008 11.08 0.000026 36.78 0.000098 140.16

Adults 20

- 49:

0.000009 13.21 0.000031 44.57 0.000124 176.68

Adults 50

- 99:

0.000009 1.25 0.000029 4.19 0.000116 16.51

Female 13

- 49:

0.000009 12.98 0.000031 43.57 0.000125 178.01



### Acute Food Only

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Acute Food Only .R08 Adjustment factor #2 NOT used.

Analysis Date: 08

- 17

- 2015/15:12:20 Residue file dated: 08

- 17

- 2015/15:07 :33
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000004 5.02 0.000007 10.09 0.000021 30.11

All Infants:

0.000002 2.59 0.000005 7.07 0.000012 16.52

Children 1

- 2:

0.000008 11.25 0.000014 19.88 0.000 063 89.55

Children 3

- 5:

0.000008 10.81 0.000015 21.64 0.000066 94.46

Children 6

- 12:

0.000006 8.24 0.000012 17.10 0.000042 60.63

Youth 13

- 19:

0.000004 5.06 0.000007 9.41 0.000027 38.99

Adults 20

- 49:

0.000002 3.43 0.000005 6.67 0.000019 27.08

Adults 50

- 99:

0.000002 0.27 0.000003 0.47 0.000008 1.16

Female 13

- 49:

0.000002 3.49 0.000005 6.79 0.000013 18.02Page 24 of 28



### Attachment 3 : Steady State (Food + Drinking Water) Results

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Steady State TXcotton

- maxrate

- BEADstartdate .R08
Adjustment factor #2 NOT used.
Analysis Date: 08

- 18

- 2015/06:59:06 Residue file dated: 08

- 1 7

- 2015/15:14:22

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

== =============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aPAD Exposure % aPAD Exp osure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000022 3.19 0.000069 9.90 0.000231 33.06

All Infants:

0.000057 189.85 0.000195 649.66 0.000721 2404.99

Children 1

- 2:

0.000034 114.82 0.000102 339.04 0.000342 1141.43

Children 3

- 5:

0.000030 101.34 0.000086 287.68 0.00 0278 927.36

Children 6

- 12:

0.000022 72.54 0.000063 209.02 0.000207 689.00

Youth 13

- 19:

0.000017 57.27 0.000052 174.84 0.000180 598.36

Adults 20

- 49:

0.000022 73.43 0.000068 227.46 0.000226 753.48

Adults 50

- 99:

0.000021 7.14 0.000066 21.89 0.000213 70.96

Female 13

- 49:

0.000022 73.19 0.000069 228.43 0.000231 769.35

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Steady State TXcotton

- typrate

- BEADdate .R08
Adjustment factor #2 NOT used.

Analysis Date: 08

- 18

- 2015/07:07:43 Residue file dated: 08

- 17

- 2015/15:15:01

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

E xposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000011 1.50 0.000030 4.25 0.000086 12.24

All Infants:

0.000023 78.02 0.000083 276.89 0.000259 864.50

Children 1

- 2:

0.000017 55.99 0.000045 150.13 0.000128 427.98

Children 3

- 5:

0.000015 50.80 0.000039 128.94 0.000 104 347.11

Children 6

- 12:

0.000011 37.81 0.000029 95.54 0.000078 259.26

Youth 13

- 19:

0.000008 28.02 0.000023 76.87 0.000067 222.38Page 25 of 28

Adults 20

- 49:

0.000010 33.34 0.000029 96.10 0.000082 273.74

Adults 50

- 99:

0.000009 3.15 0.000028 9.17 0.000078 25.87

Female 13

- 49:

0.000010 32.71 0.000029 96.71 0.000084 278.47

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Steady State TXcotton

- typrate

- 14DI .R08
Adjustment factor #2 NOT used.

Analysis Date: 08

- 18

- 201 5/07:04:53 Residue file dated: 08

- 17

- 2015/15:14:42

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposur e % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000010 1.43 0.000028 4.01 0.000076 10.89

All Infants:

0.000022 73.50 0.000078 261.51 0.000227 755.19

Children 1

- 2:

0.000016 53.39 0.000044 146.89 0.000114 379.65

Children 3

- 5:

0.000015 48.50 0.000037 124.30 0.000092 306.68

Children 6

- 12:

0.000011 36.17 0.000027 90.79 0.000069 231.24

Youth 13

- 19:

0.000008 27.05 0.000022 72.74 0.00 0059 196.63

Adults 20

- 49:

0.000010 31.97 0.000027 90.67 0.000073 242.66

Adults 50

- 99:

0.000009 2.98 0.000026 8.67 0.000068 22.76

Female 13

- 49:

0.000009 31.24 0.000027 91.35 0.000074 246.95

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Steady State NCcotton

- maxrate

. R08
Adjustment factor #2 NOT used.

Analysis Date: 08

- 18

- 2015/06:53:37 Residue file dated: 08

- 17

- 2015/15:13:44

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hou rs MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000036 5.18 0.000091 13.02 0.000216 30.91

All Infants:Page 26 of 28 0.000097 322.70 0.000277 922.50 0.000630 2099.62

Children 1

- 2:

0.000053 176.95 0.000137 456.31 0.000 324 1081.65

Children 3

- 5:

0.000046 154.31 0.000112 373.10 0.000252 841.48

Children 6

- 12:

0.000033 110.59 0.000083 275.07 0.000193 642.26

Youth 13

- 19:

0.000027 89.73 0.000071 235.45 0.000168 559.52

Adults 20

- 49:

0.000036 121.38 0.000090 300.71 0.000202 673.79

Adults 50

- 99:

0.000036 11.90 0.000085 28.35 0.000186 61.96

Female 13

- 49:

0.000036 121.00 0.000091 304.66 0.000204 681.09

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 S teady State NCcotton

- typrate .R08
Adjustment factor #2 NOT used.
Analysis Date: 08

- 18

- 2015/06:56:38 Residue file dated: 08

- 17

- 2015/15:14:04

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000008 1.11 0.000020 2.91 0.000053 7.55

All Infants:

0.000015 49.75 0.000056 185.99 0.000152 508.00

Children 1

- 2:

0.000013 42.91 0.000035 116.79 0.000079 264. 91

Children 3

- 5:

0.000012 39.98 0.000031 102.72 0.000071 235.69

Children 6

- 12:

0.000009 30.06 0.000022 73.44 0.000048 161.32

Youth 13

- 19:

0.000006 21.11 0.00001 7 55.18 0.000041 135.01

Adults 20

- 49:

0.000007 24.01 0.000020 65.12 0.000050 166.18

Adults 50

- 99:

0.000007 2.22 0.000018 6.10 0.000047 15.54

Female 13

- 49:

0.000007 23.10 0.000020 65.85 0.000050 167.41

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 0 35201 Steady State MScotton

- maxrate

- BEADstartdate .R08
Adjustment factor #2 NOT used.

Analysis Date: 08

- 18

- 2015/06:40:29 Residue file dated: 08

- 17

- 2015/15:12:03

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capi ta:Page 27 of 28 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Popu lation:

0.000021 2.95 0.000064 9.09 0.000253 36.20

All Infants:

0.000053 175.40 0.000172 573.10 0.000771 2570.91

Children 1

- 2:

0.000032 105.83 0.000093 309.93 0.000388 1291.67

Children 3

- 5:

0.000028 93.89 0.000078 260.31 0.000304 1012.26

Children 6

- 12:

0.000020 67.70 0.000058 192.09 0.000224 746.10

Youth 13

- 19:

0.000016 52.60 0.000048 160.46 0.000194 646.11

Adults 20

- 49:

0.000021 68.44 0.000062 207.35 0.000252 840.83

Adults 50

- 99:

0.000020 6.64 0.000060 20.13 0.00 0236 78.75

Female 13

- 49:

0.000020 68.16 0.000062 207.55 0.000257 855.74

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANE S 2003

- 2008 2

- Day

Residue file: 035201 Steady State MScotton

- typrate

- BEADdate .R08
Adjustment factor #2 NOT used.
Analysis Date: 08

- 18

- 2015/06:50:44 Residue file dated: 08

- 17

- 2015/15:12:43

Acute Pop Adjusted Dose (aPAD) varies with population; see indivi dual reports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- --- ------- -------- Total US Population:

0.000011 1.55 0.000029 4.21 0.000076 10.88

All Infants:

0.000025 83.41 0.000082 272.15 0.000231 768.55

Children 1

- 2:

0.000017 57.61 0.000044 147.89 0.000117 388.38

Children 3

- 5:

0.000016 51.82 0.000038 126.42 0.000093 309.20

Children 6

- 12:

0.000012 38.76 0.000028 94.29 0.000069 229.82

Youth 13

- 19:

0.000009 28.80 0.000023 75.70 0.000060 199.66

Adults 20

- 49:

0.000010 34.59 0.000028 94.89 0.000073 243.06

Adults 50

- 99:

0.000010 3.27 0.000027 9.10 0.00 0068 22.51

Female 13

- 49:

0.000010 34.15 0.000029 95.19 0.000074 246.38

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Steady State MScotton

- typrate

- 14DI .R08
Adjustment factor #2 NOT used.

Analysis Date: 08

- 18

- 2015/06:43:40 Residue file dated: 08

- 17

- 2015/15:12:25Page 28 of 28

Acute Pop Adjusted Dose (aPAD) varies with population; see individual r eports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 10281; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.000010 1.42 0.000030 4.33 0.000102 14.52

All Infants:

0.000022 72.43 0.000081 271.05 0.000307 1023.44

Children 1

- 2:

0.000016 53.32 0.000046 152.45 0.000151 503.65

Children 3

- 5:

0.000015 48.37 0.000039 129.13 0.000123 410.00

Children 6

- 12:

0.000011 36.22 0.000029 96.97 0.000091 302.80

Youth 13

- 19:

0.000008 26.88 0.000023 77.67 0.000079 262.81

Adults 20

- 49:

0.000010 32.09 0.000029 97.74 0.000100 332.76

Adults 50

- 99:

0.000009 2.99 0.000028 9.44 0.000094 31.23

Female 13

- 49:

0.000009 31.31 0.000029 97.81 0.000102 339.80



### Steady State Food Only

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for DICROTOPHOS NHANES 2003

- 2008 2

- Day

Residue file: 035201 Steady State Food Only .R08 Adjustment factor #2 NOT used.

Analysis Date: 08

- 18

- 2015/06:37:03 Residue file dated: 08

- 17

- 2015/ 15:10:19
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Two

- Day Average Results Reported
RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summ ary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ------- --- -------- Total US Population:

0.000003 0.47 0.000006 0.91 0.000018 2.63

All Infants:

0.000002 5.87 0.000005 15.30 0.000008 26.51

Children 1

- 2:

0.000007 22.28 0.000012 40.67 0.000044 145.94

Children 3

- 5:

0.000007 23.33 0.000012 39.21 0.000037 123.80

Children 6

- 12:

0.000005 16.55 0.000010 32.51 0.0 00023 78.25

Youth 13

- 19:

0.000003 10.87 0.000006 18.81 0.000017 57.57

Adults 20

- 49:

0.000002 7.32 0.000004 13.65 0.000011 37.11

Adults 50

- 99:

0.000002 0.57 0.000003 1.01 0.000006 1.96

Female 13

- 49:

0.000002 7.48 0.000004 13.12 0.000011 35.66