Exhibit 12.1
 CERTIFICATION PURSUANT TO
SEC RULE 13a-14(a)/15d-14(a)
AS ADOPTED PURSUANT TO
SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
 I, Stephen H. Willard, certify that:1.
    
    I have reviewed this annual report on Form 20-F of Flamel Technologies S.A. (the Company);2.
    
    Based on my knowledge, this report does not contain any untrue statement of a material fact or omit
to state a material fact necessary to make the statements made, in light of the circumstances under
which such statements were made, not misleading with respect to the period covered by this report;3.
    
    Based on my knowledge, the financial statements and other financial information included in this
report, fairly present in all material respects the financial condition, results of operations and
cash flows of the Company as of, and for, the periods presented in this report;4.
    
    The Companys other certifying officer and I are responsible for establishing and maintaining
disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and
15d-15(f)) for the Company and have:
 a)
    
    designed such disclosure controls and
procedures, or caused such disclosure controls
and procedures to be designed under our
supervision, to ensure that material
information relating to the Company, including
its consolidated subsidiaries, is made known
to us by others within those entities,
particularly during the period in which this
report is being prepared;b)
    
    Designed such internal control over financial
reporting, or caused such internal control
over financial reporting to be designed under
our supervision, to provide reasonable
assurance regarding the reliability of
financial reporting and the preparation of
financial statements for external purposes in
accordance with generally accepted accounting
principles.c)
    
    evaluated the effectiveness of the Companys
disclosure controls and procedures and
presented in this report our conclusions about
the effectiveness of the disclosure controls
and procedures, as of the end of the period
covered by this report based on such
evaluation; andd)
    
    disclosed in this report any change in the
Companys internal control over financial
reporting that occurred during the period
covered by this report that has materially
affected, or is reasonably likely to
materially affect, the Companys internal
control over financial reporting; and
 5.
    
    The Companys other certifying officer and I have disclosed, based on our most recent evaluation of internal
control over financial reporting, to the Companys auditors and the Audit Committee of the Companys Board of
Directors (or persons performing the equivalent functions):
 a)
    
    all significant deficiencies and material
weaknesses in the design or operation of
internal control over financial reporting
which are reasonably likely to adversely
affect the Companys ability to record,
process, summarize and report financial
information; andb)
    
    any fraud, whether or not material, that involves management or other employees who
have a significant role in the Companys
internal control over financial reporting.
  /s/ Stephen H. Willard