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Exhibit 12.1
 CERTIFICATION PURSUANT TO
SEC RULE 13a-14(a)/15d-14(a)
AS ADOPTED PURSUANT TO
SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
  1.
    
    I have reviewed this annual report on Form 20-F of Flamel Technologies S.A. (the Company);2.
    
    Based on my knowledge, this report does not contain any untrue
statement of a material fact or omit to state a material fact
necessary to make the statements made, in light of the circumstances
under which such statements were made, not misleading with respect to
the period covered by this report;3.
    
    Based on my knowledge, the financial statements and other financial
information included in this report, fairly present in all
material respects the financial condition, results of operations and
cash flows of the Company as of, and for, the periods presented in
this report;4.
    
    The Companys other certifying officer and I are responsible for
establishing and maintaining disclosure controls and procedures (as
defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
internal control
over Financial reporting (as defined in Exchange Act Rules 13a-15(f)
and 15d-15(f)) for the Company and have:
 a)
    
    designed such disclosure
controls and procedures, or
caused such disclosure controls
and procedures to be designed
under our supervision, to ensure
that material information
relating to the Company,
including its consolidated
subsidiaries, is made known to
us by others within those
entities, particularly during
the period in which this
report is being prepared;b)
    
    Designed such internal control
over financial reporting, or
caused such internal control
over financial reporting to be
designed under our supervision,
to provide reasonable assurance
regarding the reliability of
financial reporting and the
preparation of financial
statements for external purposes
in accordance with generally
accepted accounting principles.c)
    
    evaluated the effectiveness of
the Companys disclosure
controls and procedures and
presented in this report
our conclusions about the
effectiveness of the disclosure
controls and procedures, as of
the end of the period covered by
this report based on such
evaluation; andd)
    
    disclosed in this report
any change in the Companys
internal control over financial
reporting that occurred during
the period covered by this
report that has
materially affected, or is
reasonably likely to materially
affect, the Companys internal
control over financial
reporting; and
 5.
    
    The Companys other certifying officer and I have disclosed, based on
our most recent evaluation of internal control over financial
reporting, to the Companys auditors and the Audit Committee of the
Companys Board of Directors (or persons performing the equivalent
functions):
 a)
    
    all significant deficiencies and
material weaknesses in the
design or operation of internal
control over financial reporting
which are reasonably likely to
adversely affect the Companys
ability to record, process,
summarize and report financial
information; andb)
    
    any fraud, whether or not
material, that involves
management or other employees
who have a significant role in
the Companys internal control
over financial reporting.
  /s/ Stephen H. WillardStephen H. WillardChief Executive Officer