May 1994


## Documentation for Immediately Da ngerous To Life or Health Concentrations (IDLHs) 

## Toluene-2,4-diisocyanate
CAS number: 584–84–9 NIOSH REL: None established; NIOSH considers toluen e-2,4-diisocyanate to be a potential occupational carcinogen as defined by the OSHA carcin ogen policy [29 CFR 1990]. Current OSHA PEL: 0.02 ppm (0.14 mg/m ) CEILING 1989 OSHA PEL: 0.005 ppm (0.04 mg/m ) TWA, 0.02 ppm (0.15 mg/m ) STEL 1993-1994 ACGIH TLV: 0.005 ppm (0.036 mg/m ) TWA, 0.02 ppm (0.14 mg/m ) STEL Description of substance: Colorless to pale-yellow solid or liquid (above71°F) with a sharp, pungent odor. LEL: . . 0.9% (10% LEL, 900 ppm) Original (SCP) IDLH: 10 ppm Basis for original (SCP) IDLH: For this draft tech nical standard, it is assumed that individuals who have developed a sensitivity to TDI will not be allowed to work in a TDI atmosphere. In these sensitized individuals, even concentrations below the OSHA PEL are capable of triggering the allergic response. Th erefore, the IDLH has not been based on data obtained from the exposures of individuals or animals sensitizedto TDI. The ch osen IDLH is based on the 4-hour LC 50 values for different species of anim als, ranging from 9.7 to 13.9 ppm [Duncan et al. 1962 cited by AIHA 1967 and NIOSH 1973]. Short-term exposure guidelines: None developed ACUTE TOXICITY DATA : Lethal concentration data:

Species Reference LC 50 (ppm) LC Lo (ppm) Time Adjusted 0.5-hr LC (CF) Derived value Rat Duncan et al. 1962 14 ----- 4 hr 28 ppm (2.0) 2.8 ppm 3
3 3
3 3 Page 1 of 2 CDC - Immediately Dangerous to Life or Health Concentrations (IDLH): Toluen e -2, 4 -di i

...

5 / 8 /201 4 htt p ://www.cdc. g ov/niosh/idlh/584849.htmlCenters for Disease Control and Preventi on 1600 Clifton Rd. Atlanta, GA 30333, USA 800-CDC-INFO (800-232-4636) TTY: (8 88) 232-6348 - Contact CDC–INFO G. pig Mouse Rabbit Duncan et al. 1962 Duncan et al. 1962 Duncan et al. 1962 13.9 9.7 11 -----

-----

----- 4 hr 4 hr 4 hr 28 ppm (2.0) 19 ppm (2.0) 22 ppm (2.0) 2.8 ppm 1.9 ppm 2.2 ppm Other animal data: RD 50 (mouse), 0.39 ppm [Alarie 1981]. Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 2.5 ppm Basis for revised IDLH: The revised IDLH for toluene-2,4- diisocyanate is 2.5 ppm based on acute inhalation toxicity data in animal s [Duncan et al. 1962]. Since in sensitized individuals, even concentrations below the OSHA PEL are capable of triggering the allergic response, the revised IDLH has not been base d on data obtained from the exposures of individuals or animals sensitized to TDI. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for to luene-2,4-diisocyanate at any detectable concentration.] REFERENCES: 1. AIHA [1967]. Toluene diisocyanate. In: Hygienic guide series . Am Ind Hyg Assoc J 28 :90-94. 2. Alarie Y [1981]. Dose-respons e analysis in animal studies: prediction of human responses. Environ Health Perspect 42 :9-13. 3. Duncan B, Scheel LD, Fairchild EJ, Kille ns R, Graham S [1962]. Toluene diisocyanate inhalation toxicity: pathology an d mortality. Am Ind Hyg Assoc J 23 :447-456. 4. NIOSH [1973]. Criteria for a recommended st andard: toluene diisocyanate. Cincinnati, OH: U.S. Department of Health, Education, and Welfar e, Public Health Service, National Institute for Occupational Safety and Health, DHEW Publication No. HSM 73-11022. Page 2 of 2 CDC - Immediately Dangerous to Life or Health Concentrations (IDLH): Toluen e -2, 4 -di i

...

5 / 8 /201 4 htt p ://www.cdc. g ov/niosh/idlh/584849.html