----

----

| x                                                              | QUARTERLY REPORT  PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|----------------------------------------------------------------|----------------------------------------------------------------------------------------------------|
| For the quarterly period ended  March 31, 2011            |
|                                                           |
| or                                                             |
|                                                           |
| o                                                              | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934           |
|                                                           |                                                                                               |
| For the transaction period from _____________ to _____________ |
|                                                           |
| Commission file number 333-62216                               |
|                                                           |
| HEALTH DISCOVERY CORPORATION                                   |
| (Exact name of registrant as specified in its charter)         |

| Georgia(State or other jurisdiction of incorporation or organization) | 74-3002154(IRS Employer Identification No.) |
|-----------------------------------------------------------------------|---------------------------------------------|

| 2 East Bryan StreetSuite 610Savannah, Georgia 31401  |
|-----------------------------------------------------------|
|                                                      | (Address of principal executive offices) |   |

| 912-443-1987                                                                          |
|---------------------------------------------------------------------------------------|
|                                                                                  | (Registrant’s telephone number, including area code) |   |
|                                                                                  |
| (Former name, former address and former fiscal year,if changed since the last report) |

|   | Large Accelerated Filer o                                                             |                                          | Non-Accelerated Filer               o |
|--------|---------------------------------------------------------------------------------------|-----------------------------------------------|------------------------------------------------------------------------------------------------------------------|
|   |                                                                                  |                                          |                                                                                                             |
|   |                                                                                  | (do not check if a smaller reporting company) |
|   |                                                                                  |                                          |                                                                                                             |
|   | Accelerated Filer            o |                                          | Smaller Reporting Company    x                                                                    |

----

| Class:                     | Outstanding as of May 13, 2011 |
|----------------------------|--------------------------------|
|                       |                           |
| Common Stock, no par value | 229,475,747                    |
|                       |                           |
| Series A Preferred Stock   | 0                              |
|                       |                           |
| Series B Preferred Stock   | 18,777,675                     |

----

| PART I -- FINANCIAL INFORMATION                                                                      |   | 2      |
|------------------------------------------------------------------------------------------------------|--------|--------|
|                                                                                                 |   |   |
| Item 1. Unaudited Financial Statements                                                               |   | 2      |
|                                                                                                 |   |   |
|   Balance Sheet                                                                                 |   | 2      |
|                                                                                                 |   |   |
|   Statements of Operations                                                                      |   | 3      |
|                                                                                                 |   |   |
|   Statements of Cash Flows                                                                      |   | 4      |
|                                                                                                 |   |   |
|   Notes to Financial Statements                                                                 |   | 5      |
|                                                                                                 |   |   |
| Item 2. Managements’s Discussion and Analysis of Financial Condition and Results of Operations |   | 9      |
|                                                                                                 |   |   |
| Item 3. Quantitative and Qualitative Disclosures About Market Risk                                   |   | 13     |
|                                                                                                 |   |   |
| Item 4. Controls and Procedures                                                                      |   | 13     |
|                                                                                                 |   |   |
| PART II -- OTHER INFORMATION                                                                         |   | 14     |
|                                                                                                 |   |   |
| Item 1. Legal Proceedings                                                                            |   | 14     |
|                                                                                                 |   |   |
| Item 1A.Risk Factors                                                                                 |   | 14     |
|                                                                                                 |   |   |
| Item 2. Unregistered Sales of Equity Securities and Use of Proceeds                                  |   | 14     |
|                                                                                                 |   |   |
| Item 3. Defaults Upon Senior Securities                                                              |   | 14     |
|                                                                                                 |   |   |
| Item 4. [Removed and Reserved]                                                                       |   | 14     |
|                                                                                                 |   |   |
| Item 5. Other Information                                                                            |   | 14     |
|                                                                                                 |   |   |
| Item 6. Exhibits                                                                                     |   | 14     |
|                                                                                                 |   |   |
| SIGNATURES                                                                                           |   | 16     |

----

|                                                                                                                                                                                                                   |   | March 31,   |        |   | December 31, |   |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-------------|-------------|--------|--------------|--------|
|                                                                                                                                                                                                                   |   | 2011        |        |   | 2010         |   |
|                                                                                                                                                                                                                   |   | (unaudited) |        |   |         |   |
| Assets                                                                                                                                                                                                                 |   |
| Current Assets                                                                                                                                                                                                         |   |        |        |   |         |   |
|      Cash                                                                                                                                                                                     |   | $           | 2,830,908   |   |         | $      | 3,295,630 |   |
|      Accounts Receivable                                                                                                                                                                      |   |        | -           |   |         |   | 334,988 |   |
|      Prepaid Expenses and Other Assets                                                                                                                                                        |   |        | 54,837      |   |         |   | 172,034 |   |
|           Total Current Assets                                                                                                                                       |   | $           | 2,885,745   |   |         | $      | 3,802,652 |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
| Equipment, Less Accumulated Depreciation of $29,602 and $27,397                                                                                                                                                        |   |        | 21,269      |   |         |   | 23,475 |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
| Other Assets                                                                                                                                                                                                           |   |        |        |   |         |   |   |   |
|      Deferred Charges                                                                                                                                                                         |   |        | 49,996      |   |         |   | 51,740 |   |
|      Patents, Less Accumulated Amortization of $1,796,812 and $1,731,132                                                                                                                      |   |        | 2,188,983   |   |         |   | 2,254,662 |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
|           Total Assets                                                                                                                                               |   | $           | 5,145,993   |   |         | $      | 6,132,529 |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
| Liabilities and Stockholders’ Equity                                                                                                                                                                             |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
| Current Liabilities                                                                                                                                                                                                    |   |        |        |   |         |   |   |   |
|      Accounts Payable - Trade                                                                                                                                                                 |   | $           | 728,608     |   |         | $      | 820,126 |   |
|      Accrued Liabilities                                                                                                                                                                      |   |        | 38,425      |   |         |   | 122,152 |   |
|      Dividends Payable - Special                                                                                                                                                              |   |        | 22,760      |   |         |   | 22,760 |   |
|      Deferred Revenue                                                                                                                                                                         |   |        | 114,035     |   |         |   | 114,035 |   |
|            Total Current Liabilities                                                                                                                            |   | $           | 903,828     |   |         | $      | 1,079,073 |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
| Long Term Liabilities                                                                                                                                                                                                  |   |        |        |   |         |   |   |   |
|      Deferred Revenue                                                                                                                                                                         |   |        | 803,355     |   |         |   | 831,863 |   |
|      Dividends Payable                                                                                                                                                                        |   |        | 226,860     |   |         |   | 189,819 |   |
|            Total Liabilities                                                                                                                                    |   | $           | 1,934,043   |   |         | $      | 2,100,755 |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
| Stockholders’ Equity                                                                                                                                                                                             |   |        |        |   |         |   |   |   |
|      Series B Preferred Stock, Convertible 20,625,000 Shares Authorized, 18,777,675 Issued and Outstanding                                                                                    |   | $           | 1,490,015   |   |         | $      | 1,490,015 |   |
|      Common Stock, No Par Value, 300,000,000 Shares Authorized 229,475,747 Shares Issued and Outstanding March 31, 2011 229,475,747 Shares Issued and Outstanding December 31, 2010 |   |        | 25,585,569  |   |         |   | 25,593,728 |   |
|      Accumulated Deficit                                                                                                                                                                      |   |        | (23,863,634 | )      |         |   | (23,051,969 | ) |
|      Total Stockholders’ Equity                                                                                                                                                         |   | $           | 3,211,950   |   |         | $      | 4,031,774 |   |
|                                                                                                                                                                                                                   |   |        |        |   |         |   |   |   |
|      Total Liabilities and Stockholders’ Equity                                                                                                                                         |   | $           | 5,145,993   |   |         | $      | 6,132,529 |   |

----

|                                                                         |   | Three Months EndedMarch 31, 2011 |        |   | Three MonthsEndedMarch 31, 2010 |   |
|------------------------------------------------------------------------------|--------|----------------------------------|-------------|--------|---------------------------------|--------|
| Revenues:                                                                    |   |                             |        |   |                            |   |
|      Licensing & Development                    |   | $                                | 28,509      |   |                            | $      | 54,178 |   |
|                                                                         |   |                             |        |   |                            |   |   |   |
| Operating Expenses:                                                          |   |                             |        |   |                            |   |   |   |
|      Amortization                                   |   |                             | 65,680      |   |                            |   | 65,680 |   |
|      Professional and Consulting Fees               |   |                             | 197,652     |   |                            |   | 121,790 |   |
|      Legal Fees                                     |   |                             | 72,438      |   |                            |   | 178,332 |   |
|      Research & Development Fees                |   |                             | 30,410      |   |                            |   | 50,060 |   |
|      Compensation                                   |   |                             | 326,307     |   |                            |   | 397,487 |   |
|      Other General and Administrative Expenses      |   |                             | 149,768     |   |                            |   | 257,869 |   |
|         Total Operating Expenses     |   |                             | 842,255     |   |                            |   | 1,071,218 |   |
|                                                                         |   |                             |        |   |                            |   |   |   |
|      Loss From Operations                           |   |                             | (813,746    | )      |                            |   | (1,017,040 | ) |
|                                                                         |   |                             |        |   |                            |   |   |   |
| Other Income (Expense)                                                       |   |                             |        |   |                            |   |   |   |
|      Interest Income                                |   |                             | 2,081       |   |                            |   | 4,206 |   |
|      Interest Expense                               |   |                             | -           |   |                            |   | (159 | ) |
|         Total Other Income (Expense) |   |                             | 2,081       |   |                            |   | 4,047 |   |
|                                                                         |   |                             |        |   |                            |   |   |   |
| Net Loss                                                                     |   | $                                | (811,665    | )      |                            | $      | (1,012,993 | ) |
|                                                                         |   |                             |        |   |                            |   |   |   |
| Preferred Stock Dividends                                                    |   |                             | 37,041      |   |                            |   | 139,738 |   |
|                                                                         |   |                             |        |   |                            |   |   |   |
| Loss Attributable to Common Shareholders                                     |   | $                                | (848,706    | )      |                            | $      | (1,152,731 | ) |
|                                                                         |   |                             |        |   |                            |   |   |   |
| Weighted Average Outstanding Shares                                          |   |                             | 229,475,747 |   |                            |   | 201,237,709 |   |
|                                                                         |   |                             |        |   |                            |   |   |   |
| Loss Per Share (basic and diluted)                                           |   | $                                | (0.004      | )      |                            | $      | (0.010 | ) |

----

|                                                                                                                                      |   | Three Months   |      |   | Three Months   |   |
|-------------------------------------------------------------------------------------------------------------------------------------------|--------|----------------|-----------|--------|----------------|--------|
|                                                                                                                                      |   | Ended          |      |   | Ended          |   |
|                                                                                                                                      |   | March 31, 2011 |      |   | March 31, 2010 |   |
| Cash Flows From Operating Activities                                                                                                      |   |           |      |   |           |   |
|    Net Loss                                                                                                                |   | $              | (811,665  | )      |           | $      | (1,012,993 | ) |
| Adjustments to Reconcile Net Loss to Net Cash Used for Operating Activities:                                                              |   |           |      |   |           |   |   |   |
|         Stock-based Compensation                                                                  |   |           | -         |   |           |   | 21,312 |   |
|         Services Exchanged for Warrants                                                           |   |           | 28,881    |   |           |   | 33,488 |   |
|         (Increase) Decrease in Deferred Charges                                                   |   |           | 1,744     |   |           |   | (46,636 | ) |
|         Depreciation and Amortization                                                             |   |           | 67,886    |   |           |   | 67,642 |   |
|         (Increase) Decrease in Accounts Receivable                                                |   |           | 334,988   |   |           |   | (429,166 | ) |
|         Decrease in Recoverable Development Costs                                                 |   |           | 96,249    |   |           |   | - |   |
|         Increase in Interest Receivable                                                           |   |           | -         |   |           |   | (363 | ) |
|         Increase (Decrease) in Deferred Revenue                                                   |   |           | (28,509   | )      |           |   | 487,488 |   |
|         (Increase) Decrease in Prepaid Expenses and Other Assets                                  |   |           | 20,949    |   |           |   | (74,910 | ) |
|         Decrease in Accounts Payable – Trade                                                |   |           | (91,518   | )      |           |   | (29,764 | ) |
|         Increase (Decrease) in Accrued Liabilities                                                |   |           | (83,727   | )      |           |   | 179,320 |   |
|                 Net Cash Used for Operating Activities    |   |           | (464,722  | )      |           |   | (804,582 | ) |
|                                                                                                                                      |   |           |      |   |           |   |   |   |
| Cash Flows From Investing Activities:                                                                                                     |   |           |      |   |           |   |   |   |
| Purchase of Certificates of Deposit                                                                                                       |   |           | -         |   |           |   | (681,143 | ) |
| Purchase of Equipment                                                                                                                     |   |           | -         |   |           |   | (5,144 | ) |
|                 Net Cash Used for Investing Activities    |   |           | -         |   |           |   | (686,287 | ) |
|                                                                                                                                      |   |           |      |   |           |   |   |   |
| Cash Flows From Financing Activities:                                                                                                     |   |           |      |   |           |   |   |   |
| Proceeds from the Exercise of Warrants                                                                                                    |   |           | -         |   |           |   | 3,039,522 |   |
|                                                                                                                                      |   |           |      |   |           |   |   |   |
|                 Net Cash Provided by Financing Activities |   |           | -         |   |           |   | 3,039,522 |   |
|                                                                                                                                      |   |           |      |   |           |   |   |   |
|                                                                                                                                      |   |           |      |   |           |   |   |   |
| Net Increase (Decrease) in Cash                                                                                                           |   |           | (464,722  | )      |           |   | 1,548,653 |   |
|                                                                                                                                      |   |           |      |   |           |   |   |   |
| Cash, at Beginning of Period                                                                                                              |   |           | 3,295,630 |   |           |   | 2,328,912 |   |
|                                                                                                                                      |   |           |      |   |           |   |   |   |
| Cash, at End of Period                                                                                                                    |   | $              | 2,830,908 |   |           | $      | 3,877,565 |   |
|                                                                                                                                      |   |           |      |   |           |   |   |   |
| Supplemental Disclosures of Cash Flow Information:                                                                                        |   |           |      |   |           |   |   |   |
| Cash Paid for Interest                                                                                                                    |   | $              | -         |   |           | $      | 159 |   |

----

----

|                           |               |   |                          |    |   |
|--------------------------------|--------------------|--------|-------------------------------|---------|--------|
|                           |     |   | Option and WarrantShares |    |   | WeightedAverageExercise Price |
| 2010                           |               |   |                          |    |   |   |
| Outstanding, January 1, 2010   |               |   | 100,615,177                   |    |   | $ | 0.16 |   |
| Granted                        |               |   | 21,875,000                    |    |   | $ | 0.22 |   |
| Exchanged                      |               |   | (32,527,776                   | )       |   | $ | 0.17 |   |
| Exercised                      |               |   | (34,387,903                   | )       |   | $ | 0.17 |   |
| Expired un-exercised           |               |   |  (18,949,498             | )  |   | $ | 0.18 |   |
| Outstanding, December 31, 2010 |               |   | 36,625,000                    |    |   | $ | 0.16 |   |
|                           |               |   |                          |    |   |   |   |   |
| 2011                           |               |   |                          |    |   |   |   |   |   |
| Granted                        |               |   | --                            |    |   |   | -- |   |
| Exercised                      |               |   | --                            |    |   |   | -- |   |
| Expired un-exercised           |               |   | --                            |    |   |   | -- |   |
| Outstanding, March 31, 2011    |               |   | 36,625,000                    |    |   | $ | 0.16 |   |

----

| Exercise Prices |   | Number Outstanding |            |   | Weighted-Average Remaining Contractual Life (years) |   |   | NumberExercisable |   |   | Weighted Average Remaining Contractual Life (years) of Exercisable Warrants andOptions |   |
|-----------------|--------|--------------------|-----------------|--------|---------------------------------------------------------------|--------|--------|-------------------|--------|--------|---------------------------------------------------------------------------------------------|--------|
|            |   |               |            |   |                                                          |   |   |              |   |   |                                                                                        |   |
| $0.08           |   |               | 12,250,000      |   |                                                          |   | 4.0    |              |   |   | 12,250,000                                                                                  |   |   |   | 4.0 |   |
| $0.13           |   |               | 2,500,000       |   |                                                          |   | 1.0    |              |   |   | 2,500,000                                                                                   |   |   |   | 1.0 |   |
| $0.15           |   |               | 1,000,000       |   |                                                          |   | 4.5    |              |   |   | -                                                                                           |   |   |   | - |   |
| $0.17           |   |               | 6,875,000       |   |                                                          |   | 1.5    |              |   |   | 6,875,000                                                                                   |   |   |   | 1.5 |   |
| $0.19           |   |               | 2,500,000       |   |                                                          |   | 10.0   |              |   |   | 2,500,000                                                                                   |   |   |   | 10.0 |   |
| $0.25           |   |               | 10,000,000      |   |                                                          |   | 1.5    |              |   |   | 10,000,000                                                                                  |   |   |   | 1.5 |   |
| $0.26           |   |               |  1,500,000 |   |                                                          |   | 4.0    |              |   |   |  500,000                                                                               |   |   |   | 4.0 |   |
|  Total     |   |               |            |   |                                                          |   |   |              |   |   |                                                                                        |   |   |   |   |   |
|            |   |               | 36,625,000      |   |                                                          |   |   |              |   |   | 34,625,000                                                                                  |   |   |   |   |   |

----

----

----

----

----

|                 |   | Total  |    |   | 1 YearOr Less |   |   | More Than 1 Year |   |
|----------------------|--------|--------|---------|--------|---------------|--------|--------|----------------------------|--------|
| Accrued Compensation |   | $      | 26,000  |   |          | $      | 26,000 |                       |   | $ | - |   |
| Office Lease         |   |   | 204,160 |   |          |   | 40,140 |                       |   |   |  164,020 |   |
| Total                |   | $      | 230,160 |   |          | $      | 66,140 |                       |   | $ | 164,020 |   |

----

----

| 3.1 | Articles of Incorporation. Registrant incorporates by reference Exhibit 3.1 to Form 8-K filed July 18, 2007. |
|-----|--------------------------------------------------------------------------------------------------------------|

| 3.1(a) | Articles of Amendment to Articles of Incorporation.  Registrant incorporates by reference Exhibit 99.1 to Form 8-K filed October 10, 2007. |   |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------|--------|

| 3.1(b) | Articles of Amendment to Articles of Incorporation.  Registrant incorporates by reference Exhibit 3.1(b) to Form 10-K filed March 31, 2009. |   |
|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------|--------|

| 3.1(c) | Amended and Restated Articles of Amendment to Articles of Incorporation.  Registrant incorporates by reference Exhibit 3.1 to Form 10-Q filed November 16, 2009. |   |
|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|

| 3.2 | By-Laws. Registrant incorporates by reference Exhibit 3.2 to Form 8-K filed July 18, 2007. |   |
|-----|--------------------------------------------------------------------------------------------|--------|

| 4.1 | Copy of Specimen Certificate for shares of Common Stock. Registrant incorporates by reference Exhibit 4.1 to Registration Statement on Form SB-2, filed June 4, 2001. |   |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|

----

| 4.1(a) | Copy of Specimen Certificate for shares of Common Stock. Registrant incorporates by reference Exhibit 4.1 (b) to Form 10-KSB, filed March 30, 2004. |   |
|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------|--------|

| 4.1(b) | Copy of Specimen Certificate for shares of Series A Preferred Stock.  Registrant incorporates by reference Exhibit 4.1(b) to Form 10-K filed March 31, 2008. |   |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|

| 4.1(c) | Copy of Specimen Certificate for shares of Series B Preferred Stock.  Registrant incorporates by reference Exhibit 4.1(c) to Form 10-K filed March 31, 2009. |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 31.1 | Rule 13a-14(a)/15(d)-14(a) Certifications of Chief Executive Officer and Principal Financial Offier. Filed herewith |
|------|---------------------------------------------------------------------------------------------------------------------|

| 32.1 | Section 1350 Certifications of Chief Executive Officer and Principal Financial Officer. Filed herewith. |
|------|---------------------------------------------------------------------------------------------------------|

----

|               |                                                                                                                                          |                    |   |   |
|--------------------|-----------------------------------------------------------------------------------------------------------------------------------------------|-------------------------|--------|--------|
|               | Health Discovery Corporation                                                                                                                  |                    |
|               | Registrant                                                                                                                                    |                    |
|               |                                                                                                                                          |                    |   |
| Date: May 16, 2011 | By:                                                                                                                                           | /s/ Stephen D. Barnhill |   |   |
|               | Printed Name: Stephen D. Barnhill M.D.Title: Chairman, Chief Executive Officer, Principal Financial Officer, and Principal Accounting Officer |