**Exhibit 10.12(i)****FIRST AMENDMENT TO SUBLEASE**     **THIS FIRST AMENDMENT TO SUBLEASE**(“First Amendment”) is entered into as of _Nov 3, 2006, by and between ORACLE USA, INC., a Colorado corporation (“Sublandlord”) and ONYXPHARMACEUTICALS, INC., a Delaware corporation (“Subtenant”), with reference to the following facts.     A. Sublandlord (as successor in interest to Siebel Systems, Inc.) and Subtenant are parties tothat certain sublease dated August 5, 2004 (the “Sublease”), pursuant to which Sublandlord hassubleased to Subtenant space currently containing approximately 23,222 rentable square feet (the“Original Subleased Premises”) on the twelfth (12th) floor of the building located at 2100 PowellStreet, Emeryville, California (the “Building”).     B. Subtenant has requested that additional space containing approximately 14,072 rentablesquare feet on the third (3rd) floor of the Building and comprised of (i) 4,144 rentable squarefeet of office space (the “Office Space”) and (ii) 9,928 rentable square feet of space located inthe Building’s childcare facility (the “Childcare Space”), all as shown on **Exhibit A-1**hereto (theOffice Space and the Childcare Space being referred to herein collectively as the “ExpansionSpace”), be added to the Subleased Premises and that the Sublease be appropriately amended andSublandlord is willing to do the same on the following terms and conditions.     C. The Sublease by its terms shall expire on February 10, 2010 (“Prior Termination Date”), andthe parties desire to extend the term of the Sublease, all on the following terms and conditions.     **NOW, THEREFORE**, in consideration of the above recitals which by this reference areincorporated herein, the mutual covenants and conditions contained herein and other valuableconsideration, the receipt and sufficiency of which are hereby acknowledged, Sublandlord andSubtenant agree as follows:     1. Expansion.          (a) Delivery of Expansion Space. Effective as of the date that Sublandlord deliversvacant possession of the Expansion Space to Subtenant in broom clean condition (the “ExpansionEffective Date”) which date is anticipated to occur immediately following the mutual execution anddelivery of this First Amendment, the Subleased Premises, as defined in the Sublease, is increasedto 37,294 rentable square feet on the twelfth (12th) and third (3rd) floors by the addition of theExpansion Space, and from and after the Expansion Effective Date, the Original Subleased Premisesand the Expansion Space, collectively, shall be deemed the Subleased Premises, as defined in theSublease. The Term for the Expansion Space shall commence on the Expansion Effective Date and endon the Extended Termination Date (as hereinafter defined). The Expansion Space is subject to allthe terms and conditions of the Sublease except as expressly modified herein and except thatSubtenant shall not be entitled to receive any allowances, abatements or other financialconcessions of an inducement nature granted with respect to the Original Subleased Premises unlesssuch concessions are expressly provided for herein with respect to the Expansion Space. TheExpansion Effective Date shall be delayed to the extent that Sublandlord fails to deliver vacantpossession of the Expansion Space in broom clean condition for any reason, including but notlimited to, holding over by prior occupants. Any such delay in the Expansion Effective Date shallnot subject Sublandlord to any
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liability for any loss or damage resulting therefrom. If the Expansion Effective Date isdelayed, the Extended Termination Date shall not be similarly extended.          (b) Construction Contingency. This First Amendment is conditioned upon (i) bothSublandlord and Master Landlord approving (A) Subtenant’s proposed architect and general contractorfor the design and construction of Subtenant’s initial improvements within the Expansion Space,said architect and general contractor being specified in **Exhibit B**attached hereto and (B) thepreliminary space plan depicting such initial improvements, which is attached hereto as **Exhibit C**(“Preliminary Plans”) and (ii) Landlord and Sublandlord waiving any requirement that Subtenant’sinitial improvements to the Expansion Space be removed upon the expiration or sooner termination ofthe Sublease based upon review of the Preliminary Plans, provided that Subtenant’s initialimprovements in the Expansion Space do not vary materially from the Preliminary Plans(“Construction Contingency”). In connection therewith, Subtenant agrees to promptly provideSublandlord or Master Landlord, as the case may be, with such additional information regardingSubtenant’s architect, contractor, and Preliminary Plans as Sublandlord or Master Landlord mayreasonably request and to cooperate in good faith with the efforts of Sublandlord and/or MasterLandlord to evaluate same. If, despite Subtenant’s compliance with the immediately precedingsentence, the Construction Contingency is not satisfied on or before the date that is thirty (30)days following the date of mutual execution and delivery of this First Amendment, Subtenant shallhave the right to rescind this First Amendment by written notice delivered to Sublandlord at anytime prior to satisfaction of the Construction Contingency. If Subtenant so elects to rescind thisFirst Amendment, the parties shall have no further rights or obligations hereunder, but theSublease shall remain in full force and effect, without amendment. The Construction Contingency issolely for the benefit of Subtenant and may only be waived by Subtenant.     2. Extension. The Term of the Sublease is hereby extended such that it will expire onMarch 31, 2013 (“Extended Termination Date”), unless sooner terminated in accordance with the termsof the Sublease. That portion of the term of the Sublease commencing the day immediately followingthe Prior Termination Date (“Extension Date”) and ending on the Extended Termination Date shall bereferred to herein as the “Extended Term”.     3. Base Rent.          (a) Original Subleased Premises Through Prior Termination Date. The Base Rent and allother charges under the Sublease shall be payable as provided therein with respect to the OriginalSubleased Premises through and including the Prior Termination Date.          (b) Original Subleased Premises From and After Extension Date. As of the ExtensionDate, the schedule of Base Rent payable with respect to the Original Subleased Premises during theExtended Term is the following:
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           **Monthly Rate Per**  **Period** **Square Foot** **Monthly Base Rent**February 11, 2010 - December 31,2010 $2.62  $60,841.64 January 1, 2011 - December 31, 2011 $2.67  $62,002.74 January 1, 2012 - December 31, 2012 $2.75  $63,860.50 January 1, 2013 - March 13, 2013 $2.83  $65,718.26           (c) Expansion Space. Commencing as of the date that is one hundred twenty (120) daysfollowing the later to occur of (x) the Expansion Effective Date and (y) the date upon whichLandlord and Sublandlord have approved (or are deemed to have approved) the Plans, (the “ExpansionRent Commencement Date”), Subtenant shall pay Base Rent with respect to the Expansion Space asfollows (in the following chart, the term “Anniversary” refers to an anniversary of the ExpansionEffective Date):           **Monthly Rate Per**  **Period** **Square Foot** **Monthly Base Rent**Expansion Rent Commencement Date -