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Exhibit 10.43 Sale of Assets Agreement dated November 3, 2004 by and among CollaGenex International Limited,
Alliance Pharmaceuticals Limited and Alliance Pharma plc.




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Exhibit 10.43 SALE OF ASSETS AGREEMENT This Sale of Assets Agreement (this Agreement), dated as of 3 November, 2004, is between:  1.
    CollaGenex International Limited, a company organised under the laws England and Wales
(Company No. 03250062), with its registered office at The Old Stable Block, 7 Buttermarket,
Thame, Oxfordshire OX9 3EW, United Kingdom (CollaGenex), and  2.
    CollaGenex Pharmaceuticals, Inc., a company organised and existing under the laws of the
State of Delaware, and having its principle place of business at 41 University Drive, Newtown,
Pennsylvania 18940, USA (CGPI); and  3.
    Alliance Pharmaceuticals Limited, a company organised under the laws England and Wales
(Company No. 03250064), with its registered office at Avonbridge House, Bath Road, Chippenham,
Wiltshire SN15 9BB, United Kingdom (Alliance), and  4.
    Alliance Pharma plc, a company organised under the laws England and Wales (Company No.
04241478), with its registered office at Avonbridge House, Bath Road, Chippenham, Wiltshire,
SN15 9BR, as guarantor (Guarantor) WHEREAS  (A)
    CollaGenex is engaged in the business of marketing, selling and distributing doxycycline
hyclate 20mg tablets under the brand name Periostat® (the Product) in the United Kingdom and
other countries, for the treatment of periodontitis (such business being referred to as the
Dental Business), and  (B)
    CollaGenex desires to transfer and assign to Alliance, and Alliance desires to accept the
transfer and assignment from CollaGenex of, certain assets used in the Dental Business, on the
terms and conditions of this Agreement. The parties to this Agreement (the Parties) now undertake and agree as follows: I            DEFINITIONS In this Agreement, the following terms are defined in the following sections or paragraphs: Actual Completion
    
    1.1Adjustment Amount
    
    2.4Affected Party
    
    10.2Affiliate
    
    5.3Agreement
    
    PreambleAlliance
    
    PreambleBusiness Day
    
    Construction (h)




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CPGI
    
    PreambleCollaGenex
    
    Preambleday
    
    Construction (h)Dental Business
    
    PreambleDental Business Assets
    
    1.2Disclosure Letter
    
    3.9Distribution Agreement(s)
    
    1.2(e)DPA
    
    5.4(a)Escrow Completion
    
    3.1Existing Marketing Authorisation(s)
    
    1.2(c)Force Majeure
    
    10.1Guarantee
    
    3.5Guarantor
    
    PreambleInventory
    
    1.2(h)Marketing Authorisation(s)
    
    1.2(c)MR
    
    1.2(j)MR Option
    
    1.2(j)Net Trade Sales
    
    6.6Numis
    
    3.2Party(ies)
    
    PreamblePlacing Agreement
    
    3.2Placing Proceeds
    
    2.2Placing Shares
    
    2.5Product(s)
    
    PreamblePurchase Price
    
    2.1Supply Agreement
    
    1.2(i)Technical Agreement(s)
    
    1.2(k)Territory
    
    1.2(d)Trade Mark Licence
    
    1.2(f)
 II CONSTRUCTION In this Agreement, unless otherwise specified, reference to:  (a)
    Recitals, Clauses, Articles, Sections, Paragraphs, Schedules or Appendices are to Recitals,
Clauses, Articles, Sections, Paragraphs of and Schedules and Appendices to this Agreement. The
Schedules and Appendices form part of the operative provisions of this Agreement and
references to this Agreement shall, unless the context otherwise requires, include reference
to the Recitals, and Schedules and Appendices;  (b)
    a document in the agreed form is a reference to that document in the form approved and
initialled by or on behalf of each party only for the purpose of identification; (c) includes and including shall mean including without limitation;  (d)
    words denoting the singular shall include the plural and vice versa and words denoting any
gender shall include all genders; 2




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(e)
    writing shall include typewriting, printing, lithography, photography and other modes of
representing words in a legible form (other than writing on an electronic or visual display
screen) or other writing in a non-transitory form;  (f)
    a person includes any natural person, individual, firm, company, corporation, body
corporate, government, state, Governmental Authority, association, joint venture, trust or
partnership (in each case whether or not having separate legal personality and irrespective of
the jurisdiction in or under the law of which it was incorporated or exists);  (g)
    a provision of law is to be construed as a reference to that provision as the same may have
been, or may from time to time be, amended or re-enacted and shall include any rules,
regulations or subordinate legislation made pursuant to or relating to such provision of law
provided however that, as between the parties, no such amendment or re-enactment shall apply
for the purposes of this Agreement to the extent that it would impose any new or extended
obligation, liability or restriction on, or otherwise adversely affect the rights of any
party;  (h)
    a time of day is a reference to London time and a reference to a day shall mean a period of
24 hours running from midnight to midnight, The phrase Business Day shall mean a day during
which the clearing banks in both the cities of New York and London are open for retail
business; (i) $ or dollar denote the lawful currency of the United States of America;  (j)
    a company shall be construed so as to include any company, corporation or other body
corporate, wherever and however incorporated or established;  (k)
    any statute, statutory instrument, regulation, bylaw or other requirement of English law or
any English legal term for any action, remedy, method of judicial proceeding, legal document,
legal status, court, official, legal concept, doctrine or thing shall in respect of any
jurisdiction other than England be treated as a reference to that which most nearly
approximates in that jurisdiction to the relevant requirement of English law or English legal
term; In this Agreement, general words shall not be given a restrictive meaning by reason of the fact
that they are followed by particular examples intended to be embraced by the general words. The headings in this Agreement are for convenience of reference only and are to be ignored in the
interpretation of this Agreement. III            TERMS AND CONDITIONS Article 1. Transfer of Dental Business Assets  1.1
    Actual completion. Upon completion of all the actions outlined in Article 3 and
Article 3A below, which actions shall take place at the offices of Wilmer Cutler Pickering
Hale and Dorr, Alder Castle, 10 Noble Street, London EC2V 7RJ, United Kingdom, on the dates
specified in Article 3 and Article 3A respectively, or such other time or place as the Parties
may agree in writing (Actual Completion), CollaGenex shall assign, license or 3




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transfer the Dental Business Assets to Alliance in the manner set out below, and Alliance
agrees to accept such assignment, license or transfer.  1.2
    Dental Business Assets. The following assets and granted rights (as the case may be)
shall constitute the Dental Business Assets:  (a)
    All operating data and records of CollaGenex relating to the Dental Business,
including records of all Product unit sales to UK wholesalers, records of all unit and
value sales to UK dental practices, schedules (organised alphabetically and by post
code) of all UK dental practices and/or dental practitioners that have been provided
with information on the Product, and such other market related information available to
CollaGenex as Alliance may reasonably request. Such data shall be physically or
electronically delivered to Alliance within five (5) Business Days of Actual
Completion.(b)
    All marketing and promotional materials, including all printed professional and
patient materials, all exhibition stands and stand dressing and all promotional items
relating to the Dental Business. Such materials shall be collected by Alliance from
the offices of CollaGenex at a mutually convenient time, within seven (7) Business Days
of Actual Completion, at Alliances sole cost. Such materials shall be conveyed with
the right by CollaGenex to use and copy them.(c)
    The existing Marketing Authorisations, currently held in the name of CollaGenex
in:  AustriaFinlandIrelandItalyThe NetherlandsLuxembourgPortugalUnited Kingdom  Marketing Authorisations means rights to market the Product under licences or
authorisations granted by the Department of Health or analogous body or agency to
permit the marketing of the Product, which rights shall be transferred, with the
supporting dossiers (the latter within 10 Business Days of Actual Completion), to
Alliance by CollaGenex or its Affiliates pursuant to the regulations and procedures
of the relevant regulatory authorities. Those Marketing Authorisations specified
above shall be referred to as the Existing Marketing Authorisations.
Responsibility for the transfer of the Existing Marketing Authorisations into the 4




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name of Alliance and any regulatory agency fees associated with the transfer shall
be the sole responsibility of Alliance subject to CollaGenex providing such
documentation and assistance as Alliance may reasonably request.(d)
    The future right of Alliance, at its own risk and cost, to register for sale,
or to authorise or approve others to register for sale, the Product in any of the
following countries, subject only to those rights of third parties expressly referenced
in this Agreement:  The countries of the European Union for the time
being excluding those referenced in paragraph 1.2(c) aboveSwitzerlandNorwayIsraelSouth AfricaAustraliaNew Zealand  which right is hereby granted to Alliance. These countries, together with those
countries referenced in paragraph 1.2(c) above, shall constitute the Territory.(e)
    All of CollaGenex future rights and obligations under existing marketing and
distribution agreements with:  Willvonseder & Marchesani Ges.m.b.H. & Co. KG., Vienna, Austria;ISDIN S.A. Barcelona, Spain (Iberia and Greece);Karr Dental AG, Horgen, Switzerland;Taro Pharmaceutical Industries Limited, Yakum,
Israel;  (the Distribution Agreements) which shall be conveyed to Alliance by way of
novations of each of such agreements.(f)
    A royalty-free exclusive licence to use, in the Dental Business in the
Territory, without any rights of ownership in, the following trade marks:  PERIOSTAT®PS20®PERIOSTATUS® 5




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THE WHOLE MOUTH TREATMENT®PERIOSTAN®PERIOSTAND®  the terms of which license shall be set forth in the agreed form of a Trade Mark
Licence agreement to be executed at Escrow Completion (the Trade Mark Licence), by
and between Alliance and CollaGenex.(g)
    An option to take a license to use the CollaGenex trade mark PERIOCYCLINE® in
return for an agreed consideration and/or royalty, procedures for the exercise of which
shall be set forth in the Trade Mark Licence.(h)
    All inventories of the Product in U.K. livery held or ordered in the ordinary
course of business (even if not delivered) by CollaGenex in the U.K. as of the date
such inventory is counted (the Inventory). Alliance shall be afforded the
opportunity of a physical Inventory count prior to the actual transfer, such Inventory
count to be carried out by Alliance itself or by an authorised agent of Alliance (whose
identity shall be disclosed to CollaGenex) and a copy of the Inventory count shall be
provided to CollaGenex. The Inventory count shall be conducted at or prior to Actual
Completion or at such other time as shall be mutually agreed, in writing, between the
parties. Alliance shall arrange to move the Inventory to its own warehouse within
three (3) Business Days of completing the Inventory count. Costs of the transfer of
the Inventory from the warehouse of CollaGenex to the warehouse of Alliance shall be
borne by Alliance. The UK QP Certificates of Release for the Inventory shall be
provided to Alliance at the time of delivery of the Inventory. Title to the Inventory
shall not pass to Alliance until the invoice of CollaGenex has been paid in full
pursuant to section 2.6.(i)
    The right to purchase bulk Periostat® tablets from CollaGenex or its Affiliates
pursuant to the agreed form of a supply agreement to be executed at Escrow Completion
(the Supply Agreement).(j)
    The option to obtain a licence to sell and market a 40mg capsule presentation
containing doxycycline for once a day administration under the brand name Periostat-MR®
(MR) for the treatment of periodontitis in the Territory, which option right is
hereby granted to Alliance subject to the terms of Article 6 of this Agreement (the MR
Option).(k)
    All of CollaGenex rights or privileges as a party to or a third party
beneficiary under the technical agreements with:  MSAS McGregor Cory Limited trading as Exel, Banbury, Oxfordshire;Cardinal Health U.K. 417 Limited trading as Cardinal Health, Great Oakley,
Corby, Northamptonshire; and 6




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Pharmaceutical Manufacturing Research Services, Inc., 423 Sargon Way,
Horsham, Pennsylvania.  (the Technical Agreements), to the extent such rights or privileges relate to the
Dental Business in the Territory. Such rights or privileges shall be conveyed by a
novation, assignment or similar document delivered at Actual Completion. Any future
commercial, as opposed to technical, arrangements with any third party provider
(other than PMRS) of any of the services covered by the Technical Agreements will be
the responsibility of Alliance.  1.3
    Title and Risk. Except as otherwise provided in this Agreement, the title to and
risk in the Dental Business Assets shall pass to Alliance at the time of Actual Completion.
To the extent that, as a matter of law, such title or risk cannot pass to Alliance at such
time, CollaGenex shall take such actions as may be reasonably necessary as Alliances agent to
effect the intentions of this Agreement and the transactions contemplated thereby.  1.4
    Specific Exclusions. Alliance will not assume any liabilities, commitments or other
obligations of CollaGenex except those arising under the Existing Marketing Authorisations and
the Distribution Agreements after the date of Actual Completion or otherwise expressly
provided in this Agreement. In particular Alliance will not assume:  (a)
    except as provided in 13.5 any obligation of CollaGenex for expenses incurred
in connection with the negotiation or preparation for the transfer of the Dental
Business Assets;(b)
    any liability arising out of any sale, act or omission of CollaGenex which
occurred prior to Actual Completion;(c)
    any liability, contract, commitment or other obligation of CollaGenex, known or
unknown, fixed or contingent, the existence of which constitutes a breach of any
representation or warranty of CollaGenex contained in this Agreement. Article 2. Purchase Price  2.1
    Purchase Price. The consideration for the purchase of the Dental Business Assets is
$3,300,000 (the Purchase Price) which shall be satisfied, subject to Actual Completion, by
the allotment and issue of the Placing Shares to such persons as CollaGenex shall direct.  2.2
    Payment of Placing Proceeds. At Actual Completion, the Guarantor shall procure that
Numis transfers to CollaGenex, by wire transfer to a United States account nominated by
CollaGenex, all the proceeds from the allotment and issue of the Placing Shares (the Placing
Proceeds).  2.3
    Payment of Adjustment Amount. At Actual Completion, the Guarantor shall transfer or
procure the transfer of the Adjustment Amount to CollaGenex, by wire transfer to a United
States account nominated by the receiving party. If the Adjustment Amount is 7




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positive, the Adjustment Amount shall be paid by Alliance to CollaGenex. If Adjustment
Amount is negative, the Adjustment Amount shall be paid by CollaGenex to Alliance.  2.4
    Adjustment Amount. The Adjustment Amount shall be X, which shall be determined by
application of the formula: X = y  zwherey =
    the Purchase Price; andz =
    the Placing Proceeds, converted into Dollars
at the exchange rate in effect on the day of Actual Completion, and as
received in CollaGenex United States account.X shall be a Dollar amount.
  If X is positive, Alliance shall ensure that upon arrival of the funds in the United States
account nominated by CollaGenex and conversion of such funds into Dollars, the Dollar amount
of such funds shall be equal to X.  2.5
    Placing Shares. The Placing Shares means such number of ordinary shares of 1p each
in the Guarantor, that are placed and sold pursuant to the Placing Agreement in order to fund
the Purchase Price.  2.6
    Payment for the Inventory. Alliance shall additionally purchase the Inventory at a
price of £3.25 (three pounds and twenty five pence) per pack of 56 tablets. Upon confirmation
of Alliance Inventory count, CollaGenex shall invoice Alliance accordingly. The invoice of
CollaGenex for the purchase of the Inventory shall be subject to the addition of VAT at the
prevailing rate and shall be due for payment by Alliance within fifteen (15) days of its date. Article 2A. Obligations relating to the Placing Shares  2A.1 Section 103 Valuation  (a)
    Alliance will, at its own expense, procure that a report and valuation relating
to the allotment of the Placing Shares, as required by Section 103 (Section 103) of
the Companies Act 1985 is prepared and shall deliver the same to CollaGenex as soon as
possible following Escrow Completion, and in any event prior to the allotment of the
Placing Shares.(b)
    Alliance will, at its own expense, procure that all the other requirements of
Section 103 to be fulfilled by it are fulfilled in connection with the allotment of the
Placing Shares. 8




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(c)
    Alliance will indemnify, and keep indemnified, CollaGenex and its successors in
title from and against all claims, costs, expenses and demands arising from the failure
to comply with all the requirements of Section 103 and from any liability under Section
103. Article 3. Escrow Completion  3.1
    Escrow Completion. Completion of this Agreement in escrow (Escrow Completion)
shall be effective as soon as the Parties have executed this Agreement and taken all the steps
identified in this Article 3.3.2
    Placing Agreement. Each of Alliance, CollaGenex and Numis Securities Limited
(Numis) shall execute the Placing Agreement (the Placing Agreement) attached as Exhibit A
to this Agreement.3.3
    Trade Mark Licence Alliance and CollaGenex shall execute the Trade Mark Licence in
the form attached as Exhibit B to this Agreement.3.4
    Supply Agreement. Alliance and CollaGenex Pharmaceuticals Inc. shall execute the
Supply Agreement in the form attached as Exhibit C to this Agreement.3.5
    Guarantee. Alliance Pharma plc shall have executed and delivered to CollaGenex a
guarantee substantially in the form attached as Exhibit D to this Agreement (the Guarantee).3.6
    Disclosure Letter. CollaGenex shall provide to Alliance, a letter fairly disclosing
any fact or circumstance which constitutes, or which but for the giving of notice or passage
of time might constitute as at Escrow Completion, a breach of any of the warranties contained
in Article 7 of this Agreement (the Disclosure Letter). Article 3A. Actual Completion  3A.1
    Actual Completion of this Agreement shall be effected as soon as the Parties have taken all
of the steps identified in this Article 3A, which steps and documents shall remain in escrow
until the satisfaction in full of the Consideration condition at 3A.1(f) below.  (a)
    Placing Shares. The Guarantor shall have allotted and issued the
Placing Shares to the Placees, and provided CollaGenex with satisfactory evidence
confirming the same.(b)
    Marketing Authorisations. CollaGenex shall deliver to Alliance
documentation in appropriate form sufficient to enable Alliance to initiate the
transfers of all the Existing Marketing Authorisations. 9




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(c)
    Novations. CollaGenex shall deliver to Alliance documentation in
appropriate form sufficient to effect the novation of all of the Distribution
Agreements.(d)
    Technical Agreements. CollaGenex shall deliver to Alliance a notice,
assignment or similar document conveying to Alliance CollaGenex rights under the
Technical Agreements, to the extent such rights relate to the Dental Business.(e)
    Further Disclosure Letter. CollaGenex shall provide to Alliance, if
appropriate, a letter fairly disclosing any fact or circumstance which constitutes, or
which but for the giving of notice or passage of time might constitute as at Actual
Completion, a breach of any of the warranties contained in Article 7 of this Agreement
(the Further Disclosure Letter).(f)
    Consideration. The payment of the Placing Proceeds and the Adjustment
Amount having been received into the United States account nominated by CollaGenex in
accordance with Article 2.2 and Article 2.3.(g)
    Completion Certificate. The Parties shall execute a Completion
Certificate in the form attached as Exhibit E to this Agreement.  3A.2
    On execution of the Completion Certificate all documents executed or signed, and actions
taken, subject thereto shall be released from escrow and deemed to be effective. In the event
that the Consideration has not been paid by 5:00p.m. on Wednesday 10 November 2004) then any
documents executed or signed, and actions taken, subject thereto shall be deemed to be void ab
initio and ineffective and each party shall return to the other party any deeds or documents
delivered subject thereto, and this agreement shall lapse so that no party hereto shall have
any claim against the other save in relation to clause 13.5 (Termination Costs). Article 4. Post Actual Completion Undertakings of the Parties  Sales and Customer Service  4.1
    Pre Actual Completion Sales. All sales invoiced by CollaGenex up to and including
the day of Actual Completion shall be for the sole account of CollaGenex. CollaGenex shall be
responsible for collection for all such invoices, and shall advise Alliance if any such
invoices are uncollectable. If for any reason payment of such invoices is made to Alliance,
Alliance will hold such payment for the account of CollaGenex, without any right of set off.4.2
    Post Actual Completion Orders. Any orders relating to the Dental Business that are
received by CollaGenex after Actual Completion will be sent, via e-mail or telefax, to
Alliance and Alliance will have responsibility for processing such orders. All such orders,
including those received in the name of CollaGenex, shall be for the account of Alliance.4.3
    Trade Communications. All professional or trade enquiries relating to the Dental
Business and received by CollaGenex after Actual Completion (including responses to journal
inserts placed by CollaGenex) will be forwarded, unanswered and unacknowledged, by CollaGenex
to Alliance. Communications with dental practitioner or 10




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dental practice customers in relation to payment and future orders will be the
responsibility of Alliance.  4.4
    Third Party Arrangements. CollaGenex will provide such assistance as is reasonably
necessary to ensure an orderly transfer to Alliance of the relationships underlying the
Distribution Agreements, the Technical Agreements, and the Dental Business. Article 5. Post Actual Completion Undertakings of the Parties  Regulatory and Product
Registration Matters  5.1
    Transfer of Existing Marketing Authorisations. CollaGenex shall provide all such
assistance as may be reasonably requested to assist Alliance in effecting the transfer of the
Existing Marketing Authorisations (including the transfer within 10 Business Days of Actual
Completion of the supporting dossiers), provided, however, that CollaGenex shall be entitled
to be reimbursed by Alliance for any professional fees and other costs and expenses that
CollaGenex may reasonably incur in this respect.5.2
    Maintenance of Marketing Authorisations. Alliance shall maintain all Marketing
Authorisations in the Territory for the Product in the name of Alliance and/or an affiliate
and/or agent and/or distributor of Alliance, and will make such variations thereto as may be
required from time to time.5.3
    Registration Dossiers. CollaGenex shall have the right of full access at any
reasonable time during business hours on a Business Day, provided that it has given notice for
such access, to any of the registration dossiers of Alliance (or those of an Affiliate or
agent or distributor of Alliance), including stability and all other data associated with the
Product, to enable CollaGenex (or an Affiliate of CollaGenex or an authorised regulatory agent
of CollaGenex) to utilise the data contained therein for any registration applications or
potential registration applications that CollaGenex may wish to make in any jurisdiction for
any product for clinical indications outside periodontology, and as a reference in
communications with, or requests for scientific advice from, any regulatory agency in
connection with such applications. Nothing in this Article 5.3 shall limit the right of
CollaGenex to use historical back-up data for the purposes of identifying and fulfilling any
of its obligations pursuant to this Agreement. As used in this Agreement Affiliate of a
party shall mean any entity in which the party has a direct or indirect equity or income
interest ownership of at least fifty per cent (50%) or more, or any entity which, directly or
indirectly, through one or more intermediaries, controls, or is controlled by, or is under
common control with the party.5.4
    Data Protection. Notwithstanding any other provision of this agreement, Alliance
undertakes that, on receipt of the data and records of the Dental Business Assets (the
Data), on Actual Completion:  (a)
    it shall duly observe all its obligations under the Data Protection Act 1998
(DPA) which arise in connection with processing Data; 11




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(b)
    it shall send a fair processing notice to each customer and data employee
identified, in the agreed form, within 7 days of Actual Completion;(c)
    it shall obtain, and at all times maintain, a notification under the DPA
appropriate to the performance of its obligations under this Agreement. Article 6. Post Actual Completion Undertakings of the Parties  Periostat MR®  6.1
    Regular Updates. On or about January 1, 2006, and quarterly thereafter, CollaGenex
shall provide Alliance with an update regarding the progress of compiling the data relating to
MR as set out in 6.6 (c), (d), (e), and (f).6.2
    Term of MR Option. The MR Option may be exercised by written notice to CollaGenex at
any time during a period of 90 days, or such other period as the Parties may agree, beginning
on the date when Alliance notifies CollaGenex that it is ready to initiate an application for
Marketing Authorisation for MR for the treatment of periodontitis in any country or countries
in the Territory (the Option Period), provided that such notification may not be given after
December 31, 2009. If, upon receipt of such notification, CollaGenex has not completed
assembling the data and supporting documentation necessary to enable Alliance to initiate a
Marketing Authorisation application, the Option Period will not start to run until CollaGenex
has completed assembling such data and documentation.6.3
    Review of MR Material. As soon as possible after the start of the Option Period
CollaGenex will furnish Alliance with all the data and documentation that Alliance may
reasonably request to enable it to initiate an application for Marketing Authorisation for MR
for the treatment of periodontitis in any country or countries in the Territory, and Alliance
shall have the opportunity to review such material and determine whether it wishes to initiate
such an application.6.4
    Non-Exercise of MR Option. If after review of the MR data and documentation,
Alliance decides that it does not wish to initiate an application for Marketing Authorisation
for MR for the treatment of periodontitis in any country or countries in the Territory,
Alliance shall, before the expiration of the Option Period, return all such data to
CollaGenex, and Alliances right to the MR Option shall lapse.6.5
    Exercise of Option. If after review of the MR data and documentation, Alliance
decides that it does wish to initiate an application for Marketing Authorisation for MR for
the treatment of periodontitis in any country or countries in the Territory, Alliance shall,  (a)
    before the expiration of the Option Period, and as a condition to the validity
of the MR Option, pay to CollaGenex US$350,000 (three hundred and fifty thousand
Dollars); and(b)
    immediately upon the granting of a Marketing Authorisation relating to MR by
the relevant UK marketing authority, a further amount equal to: 12




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(X) thirty per cent (30%) of the aggregate Net Trade Sales of
Periostat® in the Territory during the twelve (12) month period preceding the
date of application by Alliance for a Marketing Authorisation covering MR for
the treatment of periodontitis anywhere in the Territory,provided, however,
that X shall in no event be less than $1,500,000 minus (Y) $350,000.  6.6
    Effect of Exercise. Upon Alliance exercising the MR Option, CollaGenex shall provide
or procure the provision to Alliance (as and when available) of the following:  (a)
    Documentation in the proper form necessary to extend all the rights granted in
respect of the Products under this Agreement to cover MR.(b)
    Documentation in the proper form adding Periostat-MR® (and Periostat-SR®) to
the schedule of trade marks licensed under the Trade Mark Licence;(c)
    all pharmacokinetic, bio-equivalence and other similar data relating to MR in
the possession of CollaGenex or available to CollaGenex;(d)
    all active ingredient, excipient, formulation, manufacturing and packaging
information relating to MR, including, where relevant, TSE certificates, developed by
CollaGenex and/or in the possession of CollaGenex;(e)
    access to documentation describing the patent and other intellectual property
incorporated in MR to the extent developed by or in the possession of CollaGenex and/or
access to the licensors of such intellectual property; and(f)
    an original of the final report (including all charts, tables and statistical
data) prepared in accordance with applicable US standards for the multi-centre clinical
study for MR (Protocol PERIO-DOXYMR-301).  6.7
    Royalty. Alliance further agree to pay to CollaGenex an ongoing royalty of ten per
cent (10%) of the amount by which the combined Net Trade Sales of Periostat® and MR in the
Territory in any year exceed the Net Trade Sales of Periostat® in the Territory for the twelve
(12) month period preceding the date of launch of MR in the first country in the Territory.6.8
    Access and Audit. Alliance agrees to provide CollaGenex, or its authorised
representative, with access to all of its financial records relating to the sales of
Periostat® and MR as CollaGenex may reasonably require in relation to the calculation of the
royalty described in clause 6.4. In the event of a dispute as to the amount of royalties paid
or payable, CollaGenex may, at its own expense, engage independent auditors to certify the
correctness of the royalties paid or alleged to be payable by Alliance, and Alliance shall pay
CollaGenex any royalties such auditors certify to be payable to CollaGenex in excess of the
royalties actually paid to CollaGenex. If such independent auditors certify that the 13




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royalties due exceed 105% of the royalties alleged to be payable or actually paid, then
Alliance shall additionally reimburse CollaGenex for CollaGenexs expenses in engaging such
independent auditors.  6.9
    Net Trade Sales. For the avoidance of doubt and for the purposes of this Article 6,
the term Net Trade Sales shall mean the gross invoice price received by Alliance and
attributable to a commercial sale of Periostat and/or MR to a bona fide customer of Alliance
or an Affiliate of Alliance in the Territory less returns; promotional allowances; import or
export taxes; any tax or Governmental charge levied on the sale of the Products in force from
time to time; commissions to third parties and trade discounts (which term shall include early
invoice settlement discounts) actually taken.6.10
    Supply Agreement. As soon as practicable following the exercise of the MR Option by
Alliance, CollaGenex will or will procure that its parent company, CollaGenex Pharmaceuticals,
Inc. will enter into a separate supply agreement with Alliance for Periostat-MR. Article 7. Warranties of CollaGenex In consideration of the performance of the obligations of Alliance under this Agreement, CollaGenex
makes the following warranties to Alliance, which shall be true as of the date of execution of this
Agreement and as of Actual Completion, provided, however, that Alliance shall have no right to
claim as a breach of warranty, any fact fairly disclosed in the Disclosure Letter, and its right to
claim under any warranty shall be limited to the extent Alliance knows of a breach of that
warranty, as a result of its analysis of the documents listed in the Disclosure Letter. For the
purposes of this Article 7, references to the Dislosure Letter shall, when taken in the context of
the warranties being given as at Actual Completion, be deemed to be references to the Further
Disclosure Letter:  (a)
    Organisation. CollaGenex is a corporation duly organised, validly existing and in
good standing under the laws of England and Wales, with full power and authority to conduct
the Dental Business in the Territory.(b)
    Necessary Actions; Binding Effect. CollaGenex has taken all actions necessary to
authorize the execution, delivery and performance of this Agreement, the sale of the Dental
Business Assets to Alliance, and the performance of all transactions to be performed under
this Agreement. This Agreement is a valid, legal and binding obligation of CollaGenex,
enforceable against it in accordance with its terms.(c)
    No Conflicts. The execution, delivery and performance of this Agreement will not
conflict with, or result in the breach of, the governing corporate documents of CollaGenex,
any decree or order of any court or administrative or governmental body to which CollaGenex is
subject, or any agreement, document, indenture or other instrument to which CollaGenex is a
party or by which it is bound.(d)
    Operating data and records. The operating data and records provided or to be
provided to Alliance are true and complete and do not contain any misstatement of a material
fact or 14




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omit any material fact, qualification or explanation necessary to make the statement or
information made or contained in such documents not misleading. Financial data included in
such records has been prepared in accordance with generally accepted accounting principles
applied on a consistent basis.  (e)
    Marketing Materials. The marketing and promotional materials are original
copyrighted material of CollaGenex and, so far as CollaGenex is aware, do not infringe the
intellectual property rights of any third party and have been prepared in accordance with
applicable rules and regulations of those countries in the Territory where they have been
used.(f)
    Existing Marketing Authorisations. In respect of those countries where CollaGenex
holds the Existing Marketing Authorisations, the Existing Marketing Authorisations are all the
licenses, permits, consents, authorizations and approvals required for the conduct of the
Dental Business in the country where they were issued. Except as set out in the Disclosure
Letter, all the Existing Marketing Authorisations are in full force and effect. CollaGenex is
in good standing with each of the governmental agencies that administers the Existing
Marketing Authorisations. CollaGenex makes no representation with respect to the state of the
relationship of its suppliers and manufacturers with the relevant regulatory bodies and
agencies; however CollaGenex has no information which indicates that such suppliers and
manufacturers are not in good standing. CollaGenex knows of no circumstance which might, with
the passage of time or giving of notice, render any of the foregoing statements untrue.(g)
    Distribution Agreements. The Distribution Agreements are the only contracts giving
any third party the right to market and distribute the Product in the Territory. CollaGenex
has performed all of the obligations required to be performed by it to date under such
agreements and, so far as is CollaGenex is aware, is not in default under any such agreement,
nor, so far as is CollaGenex is aware, has there been any default by any other party to any
such agreement. CollaGenex knows of no circumstance (other than the expiration of the term of
any such agreement) or threatened cancellation or dispute as a result of which any such
agreement might cease to be in full force and effect. To the best knowledge of CollaGenex,
there is no bar under any such agreement to the novation, assignment or sublease of
CollaGenexs interest under each such contract to Alliance or to the consummation of the other
transactions contemplated under this Agreement.(h)
    Technical Agreements. The Technical Agreements are all the arrangements relating to
manufacture, release, packaging, storage and freight the Product required under the
regulations governing the import and distribution of human pharmaceutical products in the
territories covered by the Existing Marketing Authorisations. CollaGenex knows of no
circumstance or threatened cancellation or dispute as a result of which any such arrangement
might cease to be continued for the benefit of Alliance. To the best knowledge of CollaGenex,
there is no bar under any such agreement to the novation, assignment or sublease of
CollaGenexs rights or privileges under each such agreement to Alliance or to the consummation
of the other transactions contemplated under this Agreement. 15




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(i)
    Intellectual Property. The trade marks referenced in the Trade Mark Licence are those
applicable to the conduct of the Dental Business. Except as set out in the Trade Mark
Licence, CollaGenex owns all right title and interest in and to such trade marks, free and
clear of all restrictions, liens, options, pledges, claims, security interest, other
encumbrances of any kind and all other third party interests. Where CollaGenex is the
licensee of any of such trade marks, CollaGenex has been granted such license right, together
with a right to sub-license, pursuant to an agreement or arrangement that is in full force and
effect, and CollaGenex knows of no circumstance (other than the expiration of the term of any
such agreement) or threatened cancellation or dispute as a result of which any such agreement
might cease to be in full force and effect. All trade mark registrations and applications
for registration referenced in the Trade Mark Licence are current and in good order.
CollaGenex has no knowledge to the effect that any third party is infringing or intending to
infringe any of such trade marks. CollaGenex has no knowledge to the effect that the Product
or processes used in connection therewith infringes or is claimed to infringe the patents or
other intellectual property rights or know-how of any third party. With respect to the Dental
Business in the Territory, CollaGenex has not granted nor is obliged to grant any licence
sub-licence or assignment in respect of any patents or know-how owned or used by it and has
not disclosed nor is obliged to disclose any know-how to any person other than its employees
or its Affiliates.(j)
    Inventory. CollaGenex owns all of the Inventory with good and marketable title, free
from all restrictions, claims, liens, options, pledges, security interests, or other
encumbrances of any kind and all other third party interests. The Inventory includes only
those products which are in good and saleable condition.(k)
    Product Liability. To the best of CollaGenex knowledge, there are no products sold in
the Dental Business by CollaGenex in circulation which were, are or will become in any
material respect faulty or defective or which did not or do not comply in any material respect
with any specifications, warranties or representations expressly or impliedly made by
CollaGenex or with all regulations, standards and requirements applicable to the countries in
the Territory in which they were sold. There are no ongoing litigations or other judicial,
arbitral, administrative or other proceedings to which CollaGenex is a party in which it is
alleged that such products are or were in circulation, and, to the best knowledge of
CollaGenex, no such litigation or other proceeding is threatened.(l)
    CollaGenex warrants that it has no employees or other staff who could be deemed to be
employees at the date of Actual Completion. Article 8. Warranties of Alliance Alliance and Guarantor, make the following warranties to CollaGenex as of the date of execution of
this Agreement and as of Actual Completion:  (a)
    Organisation. Alliance is a corporation duly organised, validly existing and in good
standing under the laws of its jurisdiction of incorporation. 16




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(b)
    Necessary Actions; Binding Effect. Alliance has taken all actions necessary to
authorize the execution, delivery and performance of this Agreement, the purchase of the
Dental Business Assets from CollaGenex, and the performance of all transactions to be
performed under this Agreement, including the issue of the Guarantee. The Asset Sale
Agreement constitutes the valid obligation of Alliance and is legally binding upon Alliance in
accordance with its terms.(c)
    No Conflicts. The execution, delivery and performance of this Agreement will not
conflict with, or result in the breach of, the governing corporate documents of Alliance, any
decree or order of any court or administrative or governmental body to which Alliance is
subject, or any agreement, document, indenture or other instrument to which Alliance is a
party or by which it is bound.(d)
    PLC. The Guarantor is a public company limited by shares incorporated in England;(e)
    AIM. The existing issued share capital of the Guarantor is admitted to trading on
the AIM market of the London Stock Exchange (AIM);(f)
    Authority to Allot. The Directors of the Guarantor are duly authorised to allot the
Placing Shares pursuant to Section 80 Companies Act 1985 and all the other requirements of
Part IV of that Act will have been complied with and all requisite waivers and consents will
have been obtained for such allotments;(g)
    Placing Agreement. Alliance and Guarantor restate for the benefit of CollaGenex
those warranties made by Alliance Pharma plc in the Placing Agreement, which are incorporated
herein by reference save insofar as such warranties relate to this Agreement and matters
recorded herein. Article 9. Survival of Warranties; Indemnities, Claims  9.1
    Survival of Warranties. All warranties, covenants and other undertakings contained
herein shall be valid and enforceable after Actual Completion and shall survive Actual
Completion for a period of one year and after one year shall be extinguished subject to
Section 9 (1).9.2
    Timing and Size of Alliance Claims. Alliance may, up to six (6) months from the
expiration of the one year period referenced in Section 9.1, notify CollaGenex of a claim for
a breach of warranty that occurred during the one year period referenced in Section 9.1,
provided, however, that Alliance shall bring no claim and CollaGenex shall not be liable under
this Article unless CollaGenexs alleged liability is for an aggregate sum exceeding
U.S.$500,000, and provided, further, however, that CollaGenexs liability for all such claims
made, if any, under the warranties or covenants contained herein shall not in any event exceed
the Purchase Price.9.3
    Inadmissable Claims. No claim for a breach of warranty shall be admissible and
CollaGenex shall not be liable in respect of such a claim to the extent that it occurs or is
increased as a result of or is attributable to: 17




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(a)
    a change in legislation which is first announced after Escrow Completion (or
Actual Completion, as the case may be); or(b)
    a voluntary transaction, act or omission by Alliance or the Guarantor or their
respective directors or employees or agents after Escrow Completion (or Actual
Completion, as the case may be).  9.4
    Reduction in Purchase Price. Without prejudice to Article 9.2, any payment made by
CollaGenex in respect of a claim made pursuant to this Article 9 shall be deemed to be a
reduction in the purchase price due to CollaGenex to the extent permitted by law.9.5
    Contingent Claims. No claim may be made against CollaGenex based upon a liability
which is contingent unless and until such contingent liability becomes an actual liability.9.6
    Third Party Recovery. If Alliance recovers (whether by payment, discount, credit,
relief or otherwise) from a third party an amount which relates to a claim, any actual
recovery shall to that extent reduce or satisfy, as the case may be, such claim.9.7
    Subsequent Recovery. If CollaGenex pays an amount in respect of a claim and Alliance
subsequently recovers (whether by payment, discount, credit, relief or otherwise) from a third
party an amount which relates to that claim, Alliance shall pay to CollaGenex an amount equal
to the lesser of the amount recovered from the third party less any reasonable costs and
expenses incurred in obtaining such recovery and the amount previously paid by CollaGenex to
Alliance.9.8
    Insured Losses. No liability of CollaGenex in respect of a breach of warranty shall
arise to the extent that it relates to a loss in respect of which Alliance is insured under
any policy of insurance and Alliance successfully recovers money under such policy.9.9
    Double Recovery. Alliance shall not be entitled to recover from CollaGenex more than
once for the same damage suffered.9.10
    Employee Claims. CollaGenex shall indemnify and keep indemnified Alliance
immediately upon demand and on a full indemnity basis against all and any claims that may be
made against Alliance by any agent or contractor or employee of CollaGenex who is employed or
may be deemed to be employed by CollaGenex and whose employment is or is deemed to be
transferred to Alliance by the Transfer of Undertakings (Protection of Employment) Regulations
1981. This indemnity shall include without limitation, all losses, damages, actions,
proceedings, claims, demands, employment tribunal awards, compensation, penalties,
liabilities, costs and expenses (including without limitation legal and other professional
fees and expenses on an indemnity basis) whatsoever including without limitation protective
awards, damages for wrongful dismissal, claims for breach of contract, unfair dismissal and
unlawful deductions from wages. 18




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Article 10. Force Majeure  10.1
    Force Majeure. All circumstances beyond the reasonable control of either party and
which have, or may have, a material effect on the ability to perform under this Agreement
including, but not limited to, failure of power or other utility or sanitary supplies or
services; fire; flood; earthquake; explosion; riot; strike or lock-out of that partys own
work force; civil insurrection or unrest; terrorist activity; war (whether war be declared or
not) and regulations of any governmental, national or trans-national authority (each a Force
Majeure) shall, for the duration and to the extent of the effects caused thereby, release the
parties from the performance of their contractual obligations hereunder.10.2
    Affected Party. The party who has suffered the Force Majeure (the Affected Party)
shall notify the other party without delay of any such incidents occurring and the parties
shall discuss the effects of such incidents on this Agreement and the measures to be taken.10.3
    Mitigation. Each party shall endeavour and take all necessary steps to avoid or
restrict Force Majeure and to mitigate any loss therefrom.10.4
    Resumption of Performance. In the event of an incident or incidents of Force
Majeure, the parties shall as soon as reasonably possible resume performance of their
obligations hereunder but in the event that Force Majeure has prevailed for a continuous
period in excess of one hundred and twenty (120) days, the party which is not the Affected
Party may terminate this Agreement immediately by notice, in writing, citing Force Majeure.10.5
    Government Restrictions. This Agreement is made subject to any laws, regulations,
orders or other restrictions on the export from the United States of America of human
pharmaceutical products as may be imposed from time to time by the Government of the United
States of America and the other countries of the Territory. Alliance acknowledges that the
export of the Product from the United States of America is subject to CollaGenex receiving the
necessary licence(s) or approval(s) for export from the United States of America and
CollaGenex shall not be liable in any way for any delays, including, without limitation,
delays in obtaining required export authorisations, which are beyond the reasonable control of
CollaGenex. Article 11. Notices All notices required or permitted under this Agreement shall be in writing and delivered by any
method providing proof of delivery or receipt. Any notice shall be deemed to have been given on
day of receipt. Notices shall be delivered to the parties at the following addresses until a
different address has been designated, by notice, to the other party:- If to CollaGenex CollaGenex International Limited
The Old Stable Block,
7 Buttermarket, 19




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Thame,
Oxfordshire OX9 3EW,
United Kingdom
Fax: +44 (0) 1844 218 795
Attention: Company Secretary
With a Copy to CollaGenex Pharmaceuticals, Inc.,
41 University Drive,
Newtown,
Pennsylvania 18940,
United States of America.
Fax: +1 215 579 8577
Attention: Chief Financial Officer If to Alliance
Alliance Pharmaceuticals Limited,
Avonbridge House,
Bath Road,
Chippenham,
Wiltshire SN15 2BB,
United Kingdom.
Fax: + 44 (0) 1249 466977
Attention: Finance Director Article 12. Dispute Resolution  12.1
    Good Faith Negotiation. The Parties shall attempt in good faith to settle among
themselves any and all disputes arising regarding the validity, interpretation or application
of this Agreement, or other disputes arising from legal relationships resulting from this
Agreement.12.2
    Referral to Senior Officers. If the Parties are unable to settle a dispute
themselves after good faith negotiation for at least 30 days from the date the dispute arose,
then such dispute shall be referred to two senior officers, one from each of the parent
companies of the Parties, one nominated by each Party, to resolve.12.3
    Mediation. If within 30 days the senior officers cannot resolve a dispute, the
parties will promptly engage a mutually acceptable mediator and work in good faith with such
mediator for a further 30 days to resolve the dispute.12.4
    Arbitration. If the Parties senior officers are unable to resolve a dispute after
good faith negotiation for a further 60 days, then the dispute shall be finally settled by
arbitration under the rules of Conciliation and Arbitration of the International Chamber of
Commerce (ICC) by one arbitrator admitted to the practice of law in a common law
jurisdiction and appointed in accordance with said rules. The language of arbitration is
English and the place of arbitration is London. Notwithstanding the application of 20




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substantive provisions of the Law of England and Wales pursuant to Section 13(c), the
arbitration proceedings shall be conducted according to the procedures of the ICC.  12.5
    Injunctive Relief. Nothing in this Article 12 shall limit either Partys right to
seek injunctive relief in appropriate circumstances in a court of competent jurisdiction. Article 13 General Provisions  13.1
    Entire Agreement. This Agreement contains the entire agreement between the parties
hereto with respect to the subject matter hereof, and no modification, amendment, supplement
or change shall be effective unless in writing and signed by authorised officers of the
parties. This Agreement supersedes all prior understandings, negotiations and agreements,
whether written or oral, relating to the subject matter hereof.13.2
    No Waiver. The waiver by either party of a breach or default of any of the
provisions contained herein shall be in writing and shall not be construed as waiver of any
succeeding breach or default or of the provision itself.13.3
    Choice of Law. This Agreement shall be governed and construed in accordance with the
laws of the England, and any disputes arising under it shall (to the extent not chosen to be
arbitrated on pursuant to 12.4 above) be resolved in the courts of England and Wales.13.4
    Injunction. Nothing in this Agreement shall limit either partys right to seek
injunctive relief in appropriate circumstances in a court of competent jurisdiction.13.5
    Expenses. Except as may be otherwise provided for in this Agreement, each of the
parties hereto shall bear its own expenses in connection with this Agreement and the
transactions contemplated hereby, save that in any event Alliance shall pay the costs of
CollaGenexs professional fees in relation to the Placing Agreement within 14 days of receipt
of such invoice.13.6
    Termination Costs. In the event of Alliance not proceeding to Actual Completion for
any reason other than a breach by CollaGenex, then Alliance shall pay liquidated damages to
CollaGenex in the amount of £50,000 (fifty thousand pounds sterling) plus any expenses
incurred by CollaGenex in connection with the transactions contemplated by this Agreement up
to such date.13.7
    Partial Invalidity. If any provision of this Agreement shall be held to be illegal
or unenforceable, such holding shall not affect the validity or enforceability of any of the
other provisions of this Agreement.13.8
    Successors. This Agreement shall be binding upon and inure to the benefit of each of
CollaGenex and Alliance and each of their respective successors and assigns.13.9
    No Partnership. Nothing in this Agreement shall create or imply any association,
partnership or joint venture between the parties, it being agreed and understood that the 21




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parties are independent contractors and neither party shall have the power or authority to
bind the other in any way.  13.10
    Third Party Rights.Nothing in this Agreement shall confer any obligations on any
person who has not executed this Agreement. The parties of this Agreement expressly agree for
the purposes of the Contracts (Rights of Third Parties) Act 1999 that they do not intend any
person other than a party to this Agreement (whether an original party or one who has adhered
by deed of adherence) to be able to enforce any term of this Agreement.13.11
    No Rescission. The Parties agree that rescission shall not be available as a remedy
for any breach of this Agreement and each agree not to claim that remedy.13.12
    Procurement by CGPI. To the extent that CollaGenex has obligations pursuant to this
Agreement that it is unable to fulfil, CGPI shall procure that such obligations shall be
fulfilled by CollaGenexs Affiliates from time to time. Article 14 Value Added Tax  14.1
    Application of article 5. CollaGenex and Alliance intend that article 5 of the Value
Added Tax (Special Provisions) Order 1995 shall apply to the sale of the Dental
Business Assets under this Agreement and agree to use all reasonable endeavours to secure that
the sale is treated as neither a supply of goods nor a supply of services under that article.   14.2
    Alliance Obligation. If nevertheless any VAT is payable on the sale of the Dental
Business Assets under this Agreement and HM Customs & Excise (Customs) have so confirmed in
writing after full disclosure of all material facts, then Alliance shall pay to CollaGenex the
amount of that VAT forthwith on payment of the VAT by CollaGenex or, if earlier,
promptly after delivery by CollaGenex to Alliance of a proper VAT invoice in respect of it.14.3
    Application of Section 49. CollaGenex and Alliance intend that s. 49 of the Value
Added Tax Act 1994 shall apply to the sale of the Dental Business Assets under this agreement
and accordingly:  (a)
    CollaGenex shall forthwith make a request to Customs for a direction that those
records be preserved by CollaGenex;(b)
    CollaGenex shall promptly notify Alliance of the result of that request and if
Customs do not grant it shall on demand deliver the records to Alliance;(c)
    CollaGenex shall:  (i)
    preserve the records for such period as may be required by law;(ii)
    so long as it preserves those records permit Alliance
reasonable access to them to inspect or make copies of them; and 22




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(iii)
    not at any time cease to preserve those records without giving
Alliance reasonable opportunity to inspect and remove such of them as Alliance
wishes; and  (d)
    if the records are delivered to Alliance under paragraph (b), paragraph (c)
shall apply as if references to CollaGenex were references to Alliance and vice versa.  14.4
    Due Registration. Alliance represents and warrants to CollaGenex that Alliance is
duly registered for VAT with registration number 682 2155 39 and that with effect from Actual
Completion the Dental Business Assets will be used by Alliance in carrying on the same kind of
business as the business carried on by CollaGenex prior to date of Actual Completion.15.
    Confidentiality. The parties agree that this Agreement and any matters contemplated
by this Agreement remain private and confidential and shall not be disclosed to any third
party except to employees and relevant professional advisers or pursuant to the marketing of
the Placing or except as may be required by law or the London Stock Exchange or NASDAQ listing
agreement or the NASDAQ listing rules.16.
    Press releases. The parties agree that publication of this Agreement and/or the
Placing Agreement or matters contemplated by such documents may be of significant commercial
or public or investor relations value to each of the parties and the parties agree to the
publishing of press releases announcing the matters contemplated in such documents either
jointly or separately provided that:-  (a)
    the text of any press release(s) must be approved, in writing, by both the
parties; and(b)
    each party shall provide the other with a list of the entities through which
such press release(s) shall be distributed,  and provided further that notwithstanding the above CollaGenex, CollaGenex Pharmaceuticals,
Inc., Alliance and the Guarantor may distribute any press release, filing or public
announcement as may be required by any applicable law or the London Stock Exchange or NASDAQ
listing agreement or the NASDAQ listing rules. Executed as of the date first above written by their authorized representatives: COLLAGENEX/s/ Andrew PowellBy:
    
    Andrew PowellVice President, General Counsel & Corporate Secretary
 23




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ALLIANCE/s/ John DawsonBy:
    
    John DawsonGUARANTOR/s/ Maddy ScottBy:
    
    Maddy ScottCGPI/s/ Andrew PowellBy:
    
    Andrew PowellVice President, General Counsel & Corporate Secretary
 24