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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



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Form 10-KSB

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|x | ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------

For the fiscal year ended December 31, 2006



| ̈ | TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------

For the transition period from                      to

Commission file
number 001-32836



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Medivation, Inc.

(Name of small business issuer in its charter)

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|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 13-3863260                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)
|                                                               | 
|55 Hawthorne Street, Suite 610 San Francisco, California 94105 |  | 94105                               
|(Address of principal executive offices)                       |  | (Zip Code)                          

(415) 543-3470

(Issuers telephone number)



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Securities registered under Section 12(b) of the Exchange Act:



|                                        |  |                                          
|--------------------------------------- |  | -----------------------------------------
|Title of each class                     |  | Name of each exchange on which registered
|Common Stock, par value $0.01 per share |  | American Stock Exchange                  

Securities registered under Section 12(g) of the Exchange Act: None

Check whether the issuer (1) filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the past 12 months (or for
such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days:    Yes  x    No ̈

Check if there is no disclosure of delinquent filers in response to Item 405 of Regulation S-B contained in this form, and no disclosure will be
contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-KSB or any amendment to this Form 10-KSB:    x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the
Exchange Act):    Yes: ̈No  x

State issuers revenues for its most recent fiscal year: $0

State the aggregate market value of the voting and non-voting common equity held by non-affiliates computed by reference to the price at which the common equity was sold, or the average bid and asked price of such
common equity, as of February 16, 2007: $318,469,496

State the number of shares outstanding of each of the issuers classes of
common equity, as of the latest practicable date: As of February 16, 2007, there were outstanding an aggregate of 27,745,718 shares of Common Stock, par value $0.01 per share

DOCUMENTS INCORPORATED BY REFERENCE

Certain portions of the Definitive Proxy
Statement with respect to the 2007 Annual Meeting of Stockholders of Medivation, Inc., to be filed pursuant to Rule 14a-101 on Schedule 14A with the Securities and Exchange Commission (the Commission) within 120 days after the
close of the fiscal year ended December 31, 2006 (the Definitive Proxy Statement), have been incorporated by reference in Part III of this Annual Report on Form 10-KSB of Medivation, Inc. (the Report).

Transitional Small Business Disclosure Format (Check one):    Yes ̈No  x



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TABLE OF CONTENTS



|           |  |                                                                                                                                       |  |     
|---------- |  | ------------------------------------------------------------------------------------------------------------------------------------- |  | ----
|           |  |                                                                                                                                       |  | Page
|           |  |                                                                                                                                      
|PART I     |  |                                                                                                                                       |  |     
|Item 1.    |  | DESCRIPTION OF BUSINESS                                                                                                               |  | 4   
|Item 2.    |  | DESCRIPTION OF PROPERTY                                                                                                               |  | 16  
|Item 3.    |  | LEGAL PROCEEDINGS                                                                                                                     |  | 16  
|Item 4.    |  | SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS                                                                                   |  | 16  
|           |  |                                                                                                                                      
|PART II    |  |                                                                                                                                       |  |     
|Item 5.    |  | MARKET FOR COMMON EQUITY AND RELATED STOCKHOLDER MATTERS                                                                              |  | 17  
|Item 6.    |  | MANAGEMENTS DISCUSSION AND ANALYSIS OR PLAN OF
OPERATION                                                                             |  | 17  
|Item 7.    |  | FINANCIAL STATEMENTS                                                                                                                  |  | 30  
|Item 8.    |  | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL
DISCLOSURE                                                  |  | 44  
|Item 8A.   |  | CONTROLS AND PROCEDURES                                                                                                               |  | 44  
|Item 8B.   |  | OTHER INFORMATION                                                                                                                     |  | 45  
|           |  |                                                                                                                                      
|PART III   |  |                                                                                                                                       |  |     
|Item 9.    |  | DIRECTORS, EXECUTIVE OFFICERS, PROMOTERS, CONTROL PERSONS AND CORPORATE GOVERNANCE;
COMPLIANCE WITH SECTION 16(a) OF THE EXCHANGE ACT |  | 46  
|Item 10.   |  | EXECUTIVE COMPENSATION                                                                                                                |  | 46  
|Item 11.   |  | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED
STOCKHOLDER MATTERS                                        |  | 46  
|Item 12.   |  | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR
INDEPENDENCE                                                             |  | 46  
|Item 13.   |  | EXHIBITS                                                                                                                              |  | 46  
|Item 14.   |  | PRINCIPAL ACCOUNTANT FEES AND SERVICES                                                                                                |  | 48  
|           | 
|SIGNATURES |  | 49                                                                                                                                   



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FORWARD-LOOKING STATEMENTS

This Report includes forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934 (the Exchange
Act). All statements other than statements of historical facts contained in this Report, including statements regarding our anticipated future clinical and regulatory milestone events, future financial position, business strategy and plans
and objectives of management for future operations, are forward-looking statements. The words believe, may, will, estimate, continue, anticipate, intend,
expect and similar expressions, as they relate to us, are intended to identify forward-looking statements. Such forward-looking statements include, without limitation, statements regarding the anticipated start dates, durations and
completion dates of our ongoing and future clinical studies, statements regarding the anticipated designs of our future clinical studies, statements regarding our anticipated future regulatory submissions, and statements regarding our anticipated
future cash position. We have based these forward-looking statements largely on our current expectations and projections about future events, including the responses we expect from the U.S. Food and Drug Administration (FDA) and other regulatory
authorities, and financial trends that we believe may affect our financial condition, results of operations, business strategy, preclinical and clinical trials and financial needs. These forward-looking statements are subject to a number of risks,
uncertainties and assumptions described in Managements Discussion and Analysis or Plan of Operation and elsewhere in this Report. These risks are not exhaustive. Other sections of this Report include additional factors which could
adversely impact our business and financial performance. Moreover, we operate in a very competitive and rapidly changing environment. New risk factors emerge from time to time and it is not possible for our management to predict all risk factors,
nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements. You should not rely upon
forward-looking statements as predictions of future events. We cannot assure you that the events and circumstances reflected in the forward-looking statements will be achieved or occur and actual results could differ materially from those projected
in the forward-looking statements. We assume no obligation to update or supplement forward-looking statements.



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PART I



|Item 1. | Description of Business.
|------- | ------------------------

The Company and our Portfolio

We are a biopharmaceutical company engaged in the acquisition, research and development of promising medical technologies. We focus
particularly on technologies that have strong intellectual property positions, address large unmet medical needs, and have the potential to enter clinical development within 12 to 18 months after acquisition, and on driving development in a rapid,
cost-effective manner. Our current portfolio consists of small molecule drugs in development to treat three large, unmet medical needsDimebon for the treatment of Alzheimers disease, Dimebon for the treatment of Huntingtons disease, and MDV3100 for the treatment of
hormone-refractory prostate cancer. Dimebon is a small molecule drug that was approved in 1983 by the Russian Ministry of Health for use as an oral antihistamine. MDV3100 is the lead development candidate in a family of approximately 170 novel small
molecules that we refer to as the MDV300 series compounds. We intend to build and maintain a portfolio of four to six development programs at all times, and remain actively engaged in evaluation of new technologies to further expand our portfolio.

Dimebon for Alzheimers Disease. In September 2006, we reported top-line results from a six-month, randomized, double-blinded,
placebo-controlled Phase 2 efficacy study of our proprietary small molecule Dimebon in 183 patients with mild to moderate Alzheimers disease. The primary and secondary endpoints in this study, which was conducted at 11 sites in Russia,
assessed cognitive function, memory, ability to perform tasks of daily living, global function and behavior, and included the same endpoints accepted by the U.S. Food and Drug Administration (FDA) to approve currently marketed drugs to treat mild to
moderate Alzheimers disease. Dimebon met all five efficacy endpoints in this study with strong statistical significance compared with placebo. In addition, Dimebon-treated patients also showed statistically significant improvement over their
own starting baseline scores on all five efficacy endpoints, meaning that patients taking Dimebon were at higher levels of performance on all five endpoints at the end of six months than they were before starting the study. Dimebon was well
tolerated in this study, with fewer serious adverse events in Dimebon-treated patients than in placebo-treated patients. Based on these results, we intend to begin global Phase 3 Alzheimers disease studies in 2008 and, if those studies
are positive, to apply for U.S. and European marketing approval in Alzheimers disease in 2010.

Dimebon for Huntingtons Disease. In
October 2006, we began a Phase 1-2a study of Dimebon for the treatment of Huntingtons disease. We are conducting this study in collaboration with the Huntington Study Group, a network of more than 250 experienced clinical trial
investigators, coordinators and consultants from more than 60 academic and research institutions throughout the United States, Canada, Europe and Australia. The Huntingtons disease clinical trial has two parts: a dose-escalation phase to
determine the optimal doses of Dimebon, followed by a three-month randomized, placebo-controlled, double-blinded phase to evaluate the safety and preliminary efficacy of those doses in approximately 75 Huntingtons disease patients. We expect
the second phase of the study to begin in the first half of 2007, after the FDA has reviewed the results of additional animal toxicology studies it required us to complete. The primary efficacy endpoint in the trial is the Unified Huntingtons
Disease Rating Scale. We expect to report the results of this study in the second half of 2007. Assuming positive results, we plan to begin global Phase 3 Huntingtons disease studies in 2008 and to apply for U.S. and European marketing
approval in Huntingtons disease in 2009.

MDV3100 for Hormone-Refractory Prostate Cancer. We expect to begin a
Phase 1-2a clinical trial of our proprietary small molecule MDV3100 in patients with hormone-refractory prostate cancer in the first half of 2007, and to report study results from the first subset of these patients in the second half of 2007.
If MDV3100 is tolerated and inhibits serum prostate-specific antigen levels in this study, we expect to proceed directly to Phase 3 clinical trials in hormone-refractory prostate cancer and to expand development of this molecule to include
hormone-sensitive prostate cancer.



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Our Corporate Structure

We have formed separate subsidiaries to hold the technologies we are developing. Our subsidiary Medivation Neurology, Inc. holds our Dimebon technology, and our subsidiary Medivation Prostate Therapeutics, Inc. holds
our MDV300 series technology.

Our History and Historical Financial Information

We are a corporation formed in Delaware in October 1995, under our former name Orion Acquisition Corp. II, to identify and consummate a business
combination. Medivation Neurology, Inc. was formed in Delaware in September 2003 to acquire and develop Dimebon. On December 17, 2004, Medivation Neurology, Inc. became our subsidiary pursuant to a merger. Medivation Prostate Therapeutics, Inc.
was formed in Delaware as our subsidiary to acquire and develop our MDV300 series technology.

Based on the accounting treatment of the
December 17, 2004 merger, the financial statements, notes thereto and other financial information contained in this Report for periods prior to December 17, 2004 reflect only the operations of Medivation Neurology, Inc. All such
information for periods after December 17, 2004 reflects the operations of Medivation and our subsidiaries, on a consolidated basis.

Early- and
Mid-Stage Studies

The data relating to our development programs generated to date have come from early- and mid-stage studies. Our
business model is based on the identification, acquisition and development of early-development stage medical technologies that have the potential to mature into successful commercial products. As with any early-development stage program, data
supporting our programs at the time we evaluate and acquire them will be incomplete and in need of repetition or validation. The development process requires, among other factors, the preparation of analytics and manufacturing practices, and the
generation of safety and efficacy data from preclinical and clinical studies, that comply with all applicable regulatory requirements. Therefore, the results of preclinical studies and early- and mid-stage clinical trials of our product candidates,
including the results of our Phase 2 clinical trial of Dimebon in Alzheimers disease, are not necessarily predictive of the results of later-stage trials. If we are unable to complete preclinical studies or clinical trials, or if the
results of these studies and trials are not satisfactory to convince regulatory authorities or potential partners of the safety and efficacy of our product candidates, we will not be able to attract partners or gain regulatory approval of any of our
current or future product candidates.

Our Dimebon Program

Preclinical Rationale for Development

Our decision to begin clinical development of Dimebon for Alzheimers
disease and Huntingtons disease, and to investigate potential clinical development of Dimebon for other neurological indications, was based in part on the following data.

Potential Neuroprotective Activity

In preclinical experiments, Dimebon demonstrated neuroprotective activity in models relevant to Alzheimers disease and Huntingtons disease. The ß-amyloid protein is a known neurotoxin that is widely believed to contribute
to the neurofibrillary tangles and plaques that characterize Alzheimers disease. When neurons are exposed to the ß-amyloid protein in vitro, a significant portion of them die. Dimebon has been shown to inhibit this ß-amyloid
induced neuron death in vitro. In addition, as described in more detail below under Performance in Animal Models of Disease and Aging, in a transgenic Drosophila(fruit fly) model of Huntingtons disease, Dimebon has
been shown to protect photoreceptor neurons against death induced by the human gene encoding the huntingtin protein, an abnormal protein widely believed to cause Huntingtons disease.



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The mechanism of action by which Dimebon may exert this activity is unknown, but may involve blockade of
mitochondrial permeability transition pores (MPTP). Mitochondria are intracellular structures that are responsible for generating energy within all cells. Mitochondria are surrounded by a membrane which contains pores, the MPTP, through which
substances can pass between the mitochondria and the surrounding cell. Mitochondrial pore opening has been associated in the published literature with the death of neurons. For example, a review article published in 2003 in The Journal of
Physiology and Biochemistry (Jordan J. et al., Mitochondrial control of neuron death and its role in neurodegenerative disorders) reports that opening mitochondrial pores can lead to neuron death by allowing excess calcium to flow
between the cytoplasm (the area of the cell surrounding the mitochondria) and the mitochondria, and by allowing so-called suicide factors (substances which induce cells to kill themselves) to escape from the mitochondria into the
cytoplasm. Preclinical data generated to date suggest that Dimebon may reduce permeability of the mitochondrial membrane, whether by means of blocking MPTP or through some other mechanism, which may protect neurons from dying.

Potential Dual Inhibition of Cholinesterase and the NMDA-Receptor

All five drugs previously approved by the FDA to treat Alzheimers disease are believed to operate by inhibiting either cholinesterase or the
N-methyl-D-aspartate receptor (NMDA-receptor). Preclinical studies have indicated that Dimebon may inhibit both cholinesterase and the NMDA-receptor. We are not aware of any other compound in development that is believed to inhibit both of these
Alzheimers disease targets.

Published literature suggests that dual-target inhibition of cholinesterase and the NMDA-receptor may be
more beneficial to Alzheimers disease patients than single-target inhibition alone. A study published in the January 21, 2004 issue of the Journal of the American Medical Association concluded that Namenda®, the leading FDA-approved NMDA-receptor inhibitor,
combined with Aricept®, the leading FDA-approved
cholinesterase inhibitor, is significantly more effective in treating the symptoms of Alzheimers disease than Aricept alone. This study compared the use of a combination of Namenda plus Aricept to Aricept alone in 404 patients with moderate to
severe Alzheimers disease. After six months of dosing, patients who took the combination therapy (Namenda plus Aricept) had significantly better outcomes on measurements of cognition, activities of daily living, global outcome and behavior
compared to patients who took Aricept alone. This study was reported by its authors to be the first to show superiority of dual-target inhibition (NMDA-receptor and cholinesterase inhibition) over single-target inhibition (cholinesterase inhibition
only) in Alzheimers disease patients.

Performance in Animal Models of Disease and Aging

Active Avoidance Model of Alzheimers Disease. In this model, a rat is housed in a two-chambered box with an overhead light in each
chamber. A few seconds after the overhead light in a chamber is turned on, an electrical shock is transmitted to the floor beneath the light. The rat quickly learns to move to the adjacent, non-electrically charged chamber as soon as the overhead
light is turned on. The rats in this study were given a neurotoxin that appears to impair their cognition and memory. The impaired rats were then treated with either control vehicle (saline), Dimebon or tacrine (the first cholinesterase inhibitor
approved by the FDA to treat Alzheimers disease, but now rarely used), and tested for their ability to avoid electrical shock, as well as for time required to move to the non-electrically charged chamber of the box. Dimebon performed
comparably or superior to tacrine in this experiment.

Morris-Water Maze Model of Alzheimers Disease. In this model, a
rat swims in a five-foot diameter vat of water containing a small submerged platform which the swimming rat cannot see. An overhead video camera tracks the rats swimming path, which is digitized, mapped and measured. The rat swims randomly in
the vat of water with no place to rest until it finds the submerged platform. The rat is trained to find the platform and once it does and remembers the location of the platform, the route that the rat takes from its starting place to the platform
becomes more direct and less random. Control rats eventually learn and remember the location of the platform and swim in a fairly direct route to the platform.



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In these experiments, rats received injections of neurotoxin, followed by treatment with placebo,
Aricept®, Namenda® or Dimebon for approximately three and one-half weeks. For approximately the
first one and one-half weeks of treatment, the rats were trained to find the submerged platform. Training was then stopped, and assessments of memory were made at approximately two and four weeks. Placebo-treated rats did not learn or remember the
location of the platform and swam randomly. By contrast, rats treated with Aricept®, Namenda®
or Dimebon all showed comparable improvement in their ability to learn and remember the platforms location, as indicated by a more direct (less random) swimming pattern to the submerged platform. After drug treatment was discontinued at the
end of approximately three and one-half weeks, rats treated with Aricept® appeared to forget the location of the submerged platform, as evidenced by their swimming pattern becoming more random and less direct, while rats treated with Namenda® or Dimebon continued to remember the location.

Drosophila Fruit Fly Model of Huntingtons Disease. The gene responsible for Huntingtons disease was discovered in 1993. This
discovery allowed scientists to develop transgenic animal models of Huntingtons diseasemodels in which the animals have been engineered to express the human Huntingtons disease gene. One such model is the Drosophilafruit
fly model. Insertion of the human Huntingtons disease gene into the Drosophilafruit fly induces many of the pathological and clinical signs of Huntingtons disease seen in humans. In this experiment, Dimebon was administered to
one group of transgenic flies in their food for a period of seven days, while the second group of transgenic flies did not receive Dimebon. At the end of this period, the eyes of each group of flies were examined under a microscope, and the numbers
of functioning photoreceptors were counted. Dimebon was found to protect these photoreceptors against the neuronal death associated with Huntingtons disease in a dose dependent manner.

Mouse Anti-Aging Study. Dimebon also has been shown to reduce certain aging-associated conditions, and to increase survival, in
normally-aging mice. In this study, 100 normally-aging mice, which have a typical lifespan of approximately two years, were given either Dimebon (dissolved in their daily drinking water, 50 mice) or a placebo (drinking water control, 50 mice) for 13
months. At the end of the study, Dimebon was found to reduce several common signs of aging associated with this animal modelcataracts (37% reduction), hair loss (44% reduction) and cachexia (age-associated weight loss). Most significantly,
Dimebon was shown to prolong survival in this experiment. At the end of the study, 83% more mice were alive in the Dimebon group than in the control group.

First Clinical IndicationAlzheimers Disease

Alzheimers Disease

Alzheimers disease, the leading cause of dementia, is characterized by the progressive loss of memory, thinking (cognitive function) and the ability
to perform the activities of daily living (global function). There is currently no cure. According to the Alzheimers Association and the American Health Assistance Foundation:



| |  |  | Alzheimers disease currently affects approximately 4.5 million people in the U.S., including as many as 10% of people aged 65 and older and nearly 50% of
those aged 85 and older.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Worldwide, Alzheimers disease affects 18 million people, and that number is expected to reach 34 million by 2025.
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | There are 350,000 new diagnoses of Alzheimers disease, and 59,000 Alzheimers disease deaths, per year in the U.S.
| | - |  | -------------------------------------------------------------------------------------------------------------------



| |  |  | Following initial diagnosis, patients live 8 years, on average, but may live up to 20 years with the disease.
| | - |  | -------------------------------------------------------------------------------------------------------------



| |  |  | Total annual expenditures on Alzheimers disease in the U.S. exceed $100 billion annually, and the average lifetime cost per Alzheimers disease patient
is $174,000.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------

The precise physical changes in the brain that produce Alzheimers disease are complex and not
completely understood. However, the two best-validated drug targets for Alzheimers disease are cholinesterase and the



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N-methyl-D-aspartate receptor (NMDA-receptor). There are only four commonly-used drugs that the FDA has approved for the treatment of Alzheimers
disease. Although the precise mechanism of action of these four drugs is unknown, three of these drugs are believed to inhibit cholinesterase, and one is believed to inhibit the NMDA-receptor. (A fifth cholinesterase-inhibiting drug, Cognex® (tacrine), was approved in 1993 but is very rarely
used.) These four drugs and their respective marketers, FDA approval dates (as listed in the FDAs on-line edition of its Orange Book) and postulated mechanisms of action (as appearing in the package inserts for these drugs) are set forth in
the following table.



|                          |  |                             |  |                   |  |                          
|------------------------- |  | --------------------------- |  | ----------------- |  | -------------------------
|Drug (Trade Name/Generic) |  | Marketed by                 |  | FDA Approval Date |  | Postulated Mechanism     
|Aricept® (donepezil)      |  | Pfizer Inc./Eisai Co., Ltd. |  | November 25, 1996 |  | Cholinesterase inhibition
|Exelon® (rivastigmine)    |  | Novartis AG                 |  | April 21, 2000    |  | Cholinesterase inhibition
|Razadyne® (galantamine)   |  | Johnson & Johnson           |  | February 28, 2001 |  | Cholinesterase inhibition
|Namenda® (memantine)      |  | Forest Laboratories, Inc.   |  | October 16, 2003  |  | NMDA-receptor inhibition 

According to Rodman and Renshaw equity research, the worldwide market for Alzheimers disease
drugs in 2005 was $3.2 billion, with the largest selling cholinesterase inhibitor, Aricept®, generating $1.9 billion of those sales. Exelon®, the second largest-selling cholinesterase inhibitor, generated $467 million in global sales for Novartis AG in 2005, while Forest Laboratories, Inc.s NMDA-receptor antagonist Namenda® generated sales of $508 million in its fiscal year
ended March 31, 2006.

The market performance of the existing Alzheimers disease therapeutics is particularly noteworthy given
that their clinical performance to date has been modest. Specifically, as stated in their FDA-approved labeling, none of the drugs approved by the FDA to treat Alzheimers disease has been proven to prevent or change the underlying process of
brain deterioration (neurodegeneration) in patients with Alzheimers disease. Rather, these drugs have been shown only to slow the worsening of the symptoms of Alzheimers diseaseprimarily loss of cognitive and global function.
Furthermore, in the studies submitted in support of applications for FDA approval of these drugs, none of these drugs was shown significantly to improve both cognitive and global function over a six-month period in the patients studied. Thus, we
believe that there is room for improvement in this large and growing pharmaceutical market.

Phase 2 Clinical Trial

In September 2006, we reported top-line results of a six-month, randomized, double-blinded, placebo-controlled Phase 2
efficacy study of Dimebon in 183 patients with mild to moderate Alzheimers disease. This study was conducted at 11 sites in Russia, pursuant to approval granted by the Russian Ministry of Health in 2005. In collaboration with our experienced
U.S. Alzheimers disease clinical advisors, we designed this study to mirror as closely as possible the design of the pivotal registration studies previously accepted by the FDA as the basis for approving drugs for the treatment of mild to
moderate Alzheimers disease. Specifically, we used the same clinical endpoints, the same duration of treatment, and substantially identical patient inclusion and exclusion criteria in our study as were used in previous pivotal registration
studies, and we took steps to ensure that the study was conducted in accordance with good clinical practices (GCP). However, we caution you that the FDA has not accepted our study as a pivotal registration study, and may never do so.

We met all five efficacy endpoints in this study with a high level of statistical significance. Compared with patients receiving placebo, patients
treated with Dimebon demonstrated highly statistically significant improvement on the studys primary efficacy endpoint, the Alzheimers Disease Assessment Scale-cognitive subscale (ADAS-cog; 4.0 point improvement in the mean change from
baseline to week 26 as compared to placebo; p < 0.0001), and on the key secondary efficacy endpoint, the Clinicians Interview-Based Impression of Changeplus caregiver assessment (CBIC-plus; 0.6 point improvement in the mean change
from baseline to week 26 as compared to placebo; p < 0.0001). Dimebon-treated patients also achieved statistically significant improvement (p < 0.01) compared with placebo-treated patients on all three of the other secondary efficacy
endpointsthe Activities of Daily Living, the Neuropsychiatric Inventory and the Mini Mental State Examination.



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In addition to these improvements in comparison to placebo, Dimebon-treated patients also showed
statistically significant improvement over their own starting baseline scores on all five efficacy endpoints used in this study (p < 0.05). This means that patients taking Dimebon were at higher levels of performance on all five endpoints at the
end of six months than they were before starting the study. By contrast, placebo-treated patients deteriorated from baseline on all five endpoints.

We are not aware of any published study in which a drug has achieved statistically significant improvement both over placebo and over baseline on these five relevant Alzheimers disease clinical endpoints.

Dimebon also was well tolerated in this study. There were fewer serious adverse events in Dimebon-treated patients than in placebo-treated patients. No
gastrointestinal side effects occurred in more than 3% of the Dimebon-treated patients except for dry mouth, which occurred in 13.5% of the Dimebon-treated patients. A higher percentage of Dimebon-treated patients than placebo-treated patients
completed the trial (87.6% and 81.9%, respectively), for an overall trial completion rate of 84.7%.

Extension of Phase 2 Clinical
Trial

We offered all patients completing the first six months of our Phase 2 study the opportunity to continue their
participation for an additional six months, and approximately 86% of these patients accepted our offer. All patients participating in the extension study remain in the same treatment group to which they were originally randomized (Dimebon or
placebo), and they, their physicians and all other people directly involved in the conduct of the study remain blinded. We expect to report top-line results from this extension study, which will provide twelve-month data on Dimebon in
Alzheimers disease patients, in the second quarter of 2007.

Subsequent Development Plans

Given the strong data generated in our Phase 2 study, we believe that aggressive further development of Dimebon to treat Alzheimers disease is
merited. We have initiated a clinical development plan which we believe will allow us to begin global Phase 3 clinical studies in Alzheimers disease in 2008 and, if those studies are positive, to apply for U.S. and European marketing
approval for Alzheimers disease in 2010. However, we caution you that these are forward-looking statements, and as such are subject to significant risk and uncertainty.

Second Clinical IndicationHuntingtons Disease

Huntingtons Disease

Huntingtons disease is a fatal neurological disorder characterized clinically by involuntary movements, loss of cognitive
function and a wide spectrum of behavioral disorders. Common motor symptoms include chorea (involuntary writhing and spasming), clumsiness and progressive loss of the abilities to walk, speak and swallow. Cognitive symptoms include loss of
intellectual speed, attention and short-term memory. Behavioral symptoms span the range of changes in personality, depression, irritability, emotional outbursts and apathy. Huntingtons disease is known to be caused by a specific genetic
mutation, which results in degeneration of neurons in many different regions of the brain. This degeneration is particularly focused in neurons located in the basal ganglia, structures deep within the brain that control many important functions,
including coordinating movement, and also in neurons on the outer surface of the brain or cortex, which controls thought, perception and memory.

There are no FDA-approved therapies to treat Huntingtons disease, and the disease is invariably fatal. Everyone who carries at least one copy of the Huntingtons disease mutation and lives long enough will develop the disease.
Symptoms generally begin between the ages of 30 and 45, but have been reported to appear as early as two years of age. Death usually occurs between 10 and 20 years after the onset of symptoms, making Huntingtons disease not only a devastating
but also a protracted illness. According to information on the website of the Hereditary Disease Foundation (www.hdfoundation.org), in the U.S. alone approximately 30,000 patients currently suffer from Huntingtons disease, and an additional
150,000 are genetically at risk for developing it. The Huntingtons Disease Society of America estimates that the prevalence of Huntingtons disease in the U.S. population is approximately 1 in 10,000 persons, as stated on its website
(www.hdsa.org).



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Phase 1-2a Clinical Trial

In October 2006, we began a Phase 1-2a clinical trial of Dimebon in patients with Huntingtons disease. The Huntingtons disease
clinical trial has two parts: a dose-escalation phase to determine the optimal doses of Dimebon, followed by a three-month randomized, placebo-controlled, double-blinded phase to evaluate the safety and preliminary efficacy of those doses in
approximately 75 Huntingtons disease patients. We expect the second phase of the study to begin in the first half of 2007, after the FDA has reviewed the results of additional animal toxicology studies it required us to complete. The primary
efficacy endpoint in the trial is the Unified Huntingtons Disease Rating Scale, and results are expected in the second half of 2007. Medivation is conducting this trial in collaboration with the Huntington Study Group, a network of more than
250 experienced clinical trial investigators, coordinators and consultants from more than 60 academic and research institutions throughout the United States, Canada, Europe and Australia.

Subsequent Development Plans

If the results of our ongoing Phase 1-2a clinical trial are positive, we intend to begin global Phase 3 clinical studies in Huntingtons disease in 2008 and, if those studies are positive, to apply for U.S. and European marketing
approval for Huntingtons disease in 2009. However, we caution you that these are forward-looking statements, and as such are subject to significant risk and uncertainty.

Potential Orphan Drug Designation

Under the Orphan Drug Act, the FDA may grant orphan drug designation to drugs intended to treat a rare disease or condition, which is generally a disease or condition that affects fewer than 200,000 individuals in the United States.
Huntingtons disease is specifically mentioned in the Orphan Drug Act as an example of an orphan indication, and the FDA previously has granted orphan drug designation to other drugs in development to treat Huntingtons disease. We
therefore believe that Dimebon qualifies for orphan drug designation for treating Huntingtons disease. If a product that has orphan drug designation subsequently receives FDA approval for the disease for which it has such designation, the
product is entitled to orphan drug exclusivity, i.e., the FDA may not approve any other applications to market the same drug for the same disease, except in very limited circumstances, for seven years. Orphan drug designation does not shorten the
duration of the regulatory review or approval process.

Potential Fast Track Status and Priority New Drug Application (NDA) Review

The FDA provides several options to facilitate development of drugs for serious, life-threatening diseasesfast track status
and priority NDA reviewthat we believe may be available for our Huntingtons disease program.

The FDAs fast-track program
is intended to facilitate the development and expedite the review of drugs that are intended for the treatment of a serious or life-threatening condition for which there is no effective treatment and demonstrate the potential to address unmet
medical needs for the condition. We believe Huntingtons disease meets the conditions for fast-track designation. If fast-track designation is obtained, the FDA may initiate review of sections of an NDA before the application is complete. This
rolling review is available if the applicant provides a schedule for the submission of the remaining information and pays applicable user fees. Fast-track designation may be withdrawn by the FDA if the FDA believes the designation is no longer
supported by data emerging in the clinical trial process.

In some cases, a fast-track designated product may also qualify for priority
review under FDA policies. A product is eligible for priority review, or review within a 6-month timeframe from the time an NDA is accepted for filing, if the product provides a significant improvement compared to marketed products in the treatment,
diagnosis or prevention of a disease. A fast-track designated product would ordinarily meet the FDAs criteria for priority review. We cannot guarantee that any of our product candidates will receive a priority review designation, or if a
priority designation is received, that review or approval, if any, will be faster than conventional FDA procedures.



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Other Potential Indications

Based on the data described above, we believe that a scientific and clinical rationale exists for exploring the potential of Dimebon to treat other human neurological diseases in addition to Alzheimers disease
and Huntingtons disease. We thus intend to conduct additional preclinical studies of Dimebon to explore its potential efficacy in other neurological indications.

Our MDV300 Series Prostate Cancer Program

Our subsidiary Medivation Prostate Therapeutics, Inc.
(MPT) owns an exclusive, worldwide commercial license to a series of novel small molecules, referred to as the MDV300 series compounds. In in vitro and in vivo studies, these compounds have demonstrated promising results, including the
ability to inhibit the growth of human hormone-refractory prostate cancer cells implanted into mice. Our lead development candidate from the MDV300 series is a molecule we refer to as MDV3100.

Prostate Cancer Statistics

According to the American Cancer Society, prostate cancer is the most commonly diagnosed cancer among men in the U.S., other than skin cancer. The American Cancer Society estimates that approximately 219,000 new cases of prostate cancer
will be diagnosed, and approximately 27,000 men will die of prostate cancer, in the U.S. alone during 2007. Prostate cancer is thus the second-leading cause of cancer death in men in the U.S., after lung cancer.

Metastatic Prostate CancerThe Hormone-Sensitive and Hormone-Refractory States

Metastatic prostate cancer is cancer that has spread beyond the prostate and surrounding tissues into distant organs and tissues. The majority of men who
die from prostate cancer die from the consequences of metastatic disease. According to the National Cancer Institute, the median survival of patients with prostate cancer that has metastasized to distant organs is usually one to three years, and
most such patients will die of prostate cancer. Metastatic prostate cancer is generally divided into two states: the hormone-sensitive state and the hormone-refractory state.

The Hormone-Sensitive State. Testosterone and other male sex hormones, known collectively as androgens, can fuel the growth of
prostate cancer cells. Androgens exert their effects on prostate cancer cells by binding to and activating the androgen receptor, which is expressed in prostate cancer cells. When they first metastasize to distant sites, most prostate cancers depend
on androgens for growth. These prostate cancers are known as hormone-sensitive cancers.

Accordingly, the leading therapies
currently used for the treatment of metastatic prostate cancer are focused on diminishing, or antagonizing, the effects of androgens on prostate cancer cells. This effect is achieved through two separate approaches. The first approach
uses drugs known as anti-androgens, which directly block the interaction of androgens with the androgen receptor. Casodex® (bicalutamide), sold by AstraZeneca PLC, is the largest selling of these drugs, with global annual sales of more than $1.2 billion in 2006 according to
the public disclosures of AstraZeneca PLC. The second approach is to reduce the amount of androgens produced in the body, primarily in the testes. This can be achieved surgically by removal of both testicles (orchiectomy) or through use of drugs
known as luteinizing hormone-releasing hormone (LHRH) agonist drugs, which lower the native production of testosterone in the testicles (sometimes called chemical castration). Anti-androgens and LHRH agonists often are given in
combination therapy, an approach known as a combined androgen blockade. However, because these therapies operate by reducing the ability of androgens to fuel the growth of prostate cancer cells, they generally are effective only on
prostate cancers which remain hormone-sensitivei.e., those which still depend on androgens for growth.



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The Hormone-Refractory State. Most metastatic prostate cancer initially is
hormone-sensitive and thus responds to hormonal therapies. However, according to a study published in the October 7, 2004 issue of The New England Journal of Medicine, virtually all hormone-sensitive metastatic prostate cancer undergoes
changes that convert it from being dependent on androgens for growth to becoming androgen-independent in a median of 18-24 months after initiation of hormonal therapy. Prostate cancer in this state is known as hormone-resistant or
hormone-refractory prostate cancer (HRPC). The switch from the hormone-sensitive to the hormone-refractory state following initiation of hormonal therapy is generally determined based on either rising levels of prostate-specific antigen
(PSA) or documented disease progression as evidenced by imaging tests or clinical symptoms. Metastatic prostate cancer that has become hormone-refractory is extremely aggressive; these patients have a median survival of only 10 to 12 months.

A primary reason that HRPC is so deadly is that it is difficult to treat. HRPC no longer responds to hormonal therapies that are effective
in the hormone-sensitive state. To further complicate the situation, due to biological changes in prostate cancer that has entered the hormone-refractory state, drugs that initially block the androgen receptor and inhibit growth of hormone-sensitive
prostate cancer may have precisely the opposite effect and start to fuel the growth of HRPC. Agents are clearly needed to improve the treatment options for patients with HRPC.

Switch from the Hormone-Sensitive to the Hormone-Refractory State

One of the factors that historically hindered the development of drugs to treat HRPC was that the cause of the switch from the hormone-sensitive to the
hormone-refractory state was not known. This problem recently was addressed by Dr. Charles Sawyers and his colleagues at the Howard Hughes Medical Institute and the University of California, Los Angeles, who discovered that one of the important
mechanisms by which prostate cancer cells switch from the hormone-sensitive to the hormone-refractory state appears to be through overexpression of the androgen receptor. In the published results of experiments comparing gene expression in
hormone-sensitive and hormone-refractory prostate cancer cells, published in the January 1, 2004 issue of Nature Medicine, Dr. Sawyers and his colleagues reported that an increase in androgen receptor expression was the only gene
change consistently associated with hormone-refractory disease. In a series of experiments, scientists showed (as expected) that activation of the androgen receptor in hormone-sensitive human prostate cancer cell lines was inhibited by current
androgen receptor blockers, including Casodex®.
However, when the prostate cancer cell lines were genetically engineered to overexpress the androgen receptor (converting them from the hormone-sensitive to the hormone-refractory state), not only did Casodex® fail effectively to inhibit the androgen receptor in these cells, but in some cases it
became a stimulant of the androgen receptor. Androgen receptor activation is correlated with the growth of prostate cancer. This finding is consistent with the published human clinical experience with Casodex® in HRPC.

The MDV300 Series Compounds

Prompted by the discovery of a mechanism by which prostate cancer
shifts from the hormone-sensitive to the hormone-refractory state, Dr. Michael Jung and his colleagues in the Department of Chemistry at the University of California, Los Angeles, synthesized a series of organic small molecules, which we refer
to as the MDV300 series compounds, which bind to and block the androgen receptor. Based upon the discovery that androgen receptor overexpression converts prostate cancer from the hormone-sensitive to hormone-refractory state, these scientists
hypothesized that HRPC might be more effectively treated with agents that bind to and block the androgen receptor in a different manner than Casodex® or other androgen receptor blockers currently used for the treatment of hormone-sensitive prostate cancer. The MDV300 series compounds consist of
approximately 170 chemical entities.

Existing Preclinical Data

Experiments Using Human HRPC Cells. In these experiments, human HRPC cell lines were created by engineering cultured human prostate cancer
cells to overexpress the androgen receptor. Both MDV300 series



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compounds and Casodex®, the leading FDA-approved therapy for hormone-sensitive prostate cancer, were then tested in these human HRPC cells. The impact of these drugs on four endpoints of potential interest in
treating HRPC was measuredthe degree to which they activated the androgen receptor, the degree to which they affected the expression of PSA, the degree to which they inhibited the growth of human HRPC cells, and the degree to which they
inhibited the growth of tumors due to human HRPC cells that had been implanted into mice. MDV300 series compounds showed promising effects in these experiments while Casodex®, as would be expected based on its known limited efficacy in treating HRPC, did not. In our opinion, the results of
these experiments provide a scientific rationale for considering MDV300 series compounds as potential therapeutic agents for HRPC.

Experiments Using Human Hormone-Sensitive Prostate Cancer Cells. These experiments used human prostate cancer cell lines that had not been engineered to overexpress the androgen receptor, and thus remained in the
hormone-sensitive state. Both MDV300 series compounds and Casodex® were tested in these human hormone-sensitive prostate cancer cells for their ability to inhibit cell growth. As expected based on its demonstrated efficacy in treating hormone-sensitive prostate cancer, Casodex® inhibited cell growth in these experiments.
Significantly, however, MDV300 series compounds also inhibited the growth of these hormone-sensitive prostate cancer cellscomparably to, and in certain cases better than, Casodex®. In our opinion, the results of these experiments provide a scientific rationale for
considering MDV300 series compounds as potential therapeutic agents for hormone-sensitive prostate cancer as well as for HRPC.

Rationale for Further Development

We believe that the MDV300 series compounds show promise as potential prostate
cancer therapeutics for several reasons. First, we believe that the data described above, which were conducted using human prostate cancer cell lines, suggest that these drugs may have clinical activity in HRPC, an indication for which a large unmet
medical need presently exists. Second, the performance of Casodex® in these experimentssuggesting limited efficacy in treating HRPCis consistent with what has been seen previously in clinical practice. This factor increases our confidence that the human HRPC cell lines
used in these experiments may be predictive of actual human HRPC. Third, unlike in most cancers, in prostate cancer there is a widely used surrogate marker of tumor growthPSA. By monitoring PSA levels in our early clinical trials, we believe
we will be able to obtain indications of any potential efficacy earlier than would be the case in other cancers lacking such surrogate markers. In prostate cancer patients, PSA levels are used as a proxy to track tumor growth. We believe this will
improve the efficiency of the development process and reduce the risk profile by accelerating the determination of the clinical activity and optimum doses of our selected compounds. Finally, the performance of MDV300 series compounds in these
experiments suggests not only potential efficacy in treating HRPC, but also potential efficacy in treating hormone-sensitive prostate cancer, which is known to be sensitive to agents that block the androgen receptor.

Phase 1-2a Clinical Trial and Subsequent Development Plans

We expect to begin a U.S. Phase 1-2a trial of MDV3100 in patients with HRPC in the first half of 2007. Study results from the first subset of patients in the Phase 1-2a study are expected in the second half
of 2007. If MDV3100 is tolerated and inhibits serum PSA levels in this study, we expect to proceed directly to Phase 3 clinical trials in HRPC. We also anticipate initiating development of MDV3100 in hormone-sensitive prostate cancer if the
results of our planned Phase 1-2a trial in HRPC are positive. However, we caution you that these are forward-looking statements and are subject to significant risk and uncertainty.

Potential Orphan Drug Designation

Under the Orphan Drug Act, the FDA may grant orphan drug designation to drugs intended to treat a rare disease or condition, which is generally a disease or condition that affects fewer than 200,000 individuals in the United States. The FDA
previously has granted orphan drug designation to other drugs in development to treat



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HRPC, or the symptoms associated with this disease. We therefore believe that our MDV300 series compounds qualify for orphan drug designation for treating
HRPC. If a product that has orphan drug designation subsequently receives FDA approval for the disease for which it has such designation, the product is entitled to orphan drug exclusivity, i.e., the FDA may not approve any other applications to
market the same drug for the same disease, except in very limited circumstances, for seven years. Orphan drug designation does not shorten the duration of the regulatory review or approval process.

Intellectual Property

As of December 31, 2006,
we owned issued patents in the U.S., Europe and Hong Kong claiming the use of Dimebon and certain related compounds to treat neurodegenerative diseases, and an issued patent in the U.S. claiming the use of Dimebon to treat Alzheimers disease.
The U.S. and European patents expire in October 2016. However, if we succeed in receiving regulatory approval to sell Dimebon, then under current laws our patent protection for Dimebon for the first approved indication may be eligible for extension
for up to five additional years. We also own multiple pending patent applications claiming, among other things, the use of Dimebon to treat Huntingtons disease and other undisclosed indications. We own all of the above Dimebon intellectual
property and have full control over prosecution and enforcement against potential infringers. In addition, we have an exclusive license to multiple pending patent applications covering the MDV300 series compounds, including our lead development
candidate MDV3100, and their uses in the treatment and prevention of disease. We intend to prosecute all of our owned intellectual property, and request that our licensors prosecute all of our licensed intellectual property, in the U.S., Europe and
other jurisdictions that we deem appropriate.

We require our employees and consultants to execute non-disclosure and proprietary rights
agreements at the beginning of employment or consulting arrangements with us. These agreements generally acknowledge our exclusive ownership of all intellectual property, including, but not limited to patents, developed by the individual during the
course of his or her work with us and require that all proprietary information disclosed to the individual remain confidential. We intend to enforce vigorously our intellectual property rights if infringement or misappropriation occurs.

Competition

The drug and medical device markets
are intensely competitive in general. Furthermore, our business strategy is to target large unmet medical needs, and those markets are even more highly competitive. For example, there are four drugs currently marketed to treat Alzheimers
disease, and these drugs all target at least one of the same mechanisms as does Dimebon. In addition, the approved Alzheimers disease drugs are all dosed once or twice per day, while Dimebon was dosed three times per day in our Phase 2
clinical trial. This difference in dosing regimen may make Dimebon less competitive than alternative Alzheimers disease drugs if Dimebon receives marketing approval based on a thrice per day dosing regimen. Companies marketing these
FDA-approved Alzheimers disease therapeutics include some of the worlds largest and most experienced pharmaceutical companies, such as Pfizer Inc., Novartis AG and Johnson & Johnson. There are also dozens of additional small
molecule and recombinant protein candidates in development targeting the clinical indications we are pursuing, particularly Alzheimers disease and HRPC, including compounds already in Phase 3 clinical trials. One or more such compounds
may be approved in each of our target indications before any of our product candidates could potentially be approved. Most, if not all, of these competing drug development programs are being conducted by pharmaceutical and biotechnology companies
with considerably greater financial resources, human resources and experience than ours. Any of our product candidates that receives regulatory approval will face significant competition from both approved drugs, as well as from any of the drugs
currently under development that may subsequently be approved. Bases upon which our product candidates would have to compete successfully include efficacy, safety, price and cost-effectiveness. In addition, our product candidates would have to
compete against these other drugs with several different categories of decision makers, including physicians, patients, government and private third-party payors, technology assessment groups and patient advocacy organizations. Even if one of our
product candidates is approved, we cannot guarantee that we or any



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of our partners will be able to compete successfully on any of these bases. Any future product candidates that we may subsequently acquire will face similar
competitive pressures. If we or our partners cannot compete successfully on any of the bases described above, our business will not succeed.

Manufacturing

Dimebon

The Dimebon tablets and matching placebos we used in our Phase 2 Alzheimers disease clinical trial, including the ongoing extension phase of that trial, were produced by a Russian company that is licensed by the
Russian government to manufacture Dimebon tablets for human use in Russia (where Dimebon has been approved for human use as an anti-histamine since 1983) and has engaged in such manufacture for several years. The Dimebon tablets and matching
placebos being used in our Phase 1-2a Huntingtons disease clinical trial were manufactured in the U.S. under conditions complying with U.S. good manufacturing practices (GMP).

We believe that the Dimebon manufactured to date under U.S. GMP-compliant conditions will be sufficient to supply our presently anticipated preclinical
and clinical studies in both the Alzheimers disease and Huntingtons disease indications before Phase 3. However, we believe that our existing manufacturing process for Dimebon is not optimal for Phase 3 clinical trials and
commercialization because it involves use of a chemical that is hazardous to handle, difficult to source and expensive to process. We are refining our manufacturing process to avoid use of this chemical in order to manufacture Dimebon at
commercial-scale on a cost-effective basis. We expect this process development and associated scale-up work to be completed in time to support our goal of starting global Phase 3 clinical studies in Alzheimers disease and
Huntingtons disease in 2008. However, we caution you that this is a forward-looking statement and that we cannot guarantee that we will be able to complete this work on a timely basis or at all.

MDV3100

The MDV3100 to be
used in our upcoming Phase 1-2a clinical trial in HRPC was manufactured under U.S. GMP-compliant conditions at laboratories located in the U.S. Based on currently available information, we believe that the existing process for manufacturing
MDV3100 is suitable for scale-up to commercial-scale on a cost-effective basis.

Scientific and Clinical Advisory Board

We maintain a Scientific and Clinical Advisory Board comprised of scientists and physicians with experience relevant to our company and our product
candidates. Members of our Scientific and Clinical Advisory Board have agreed to consult and advise us in their respective areas of expertise. We have placed special emphasis on identifying members of our Scientific and Clinical Advisory Board with
expertise in the treatment of the clinical indications targeted by our programs. Our Scientific and Clinical Advisory Board consists of the following members:

Paul Aisen, M.D. Dr. Aisen is a Professor of Neurology and Medicine, Vice Chair of the Department of Neurology and the Director of the Memory Disorders Program at Georgetown University School of Medicine.
Dr. Aisen was one of the first Alzheimers disease clinical trialists in the U.S., and was an investigator in the pivotal FDA registration studies for Namenda®. Dr. Aisen also serves as the Associate Director of the Alzheimers Disease Cooperative Study Group.
Dr. Aisen received his M.D. from Columbia University, College of Physicians and Surgeons.

Sergey Bachurin, Ph.D., D.Sc., Prof.
Dr. Bachurin is the Director of the Institute of Physiologically Active Compounds in Chernogolovka, Russia, and a member of the Russian Academy of Sciences. Dr. Bachurin has served as a visiting scholar at several U.S. academic research
centers, including the University of California, San Francisco, Tufts University and St. Elizabeths Medical Center. Dr. Bachurin holds a Ph.D. in Chemical Catalysis and a D.Sc. in Biochemistry from Moscow State University. In addition,
Dr. Bachurin holds a Professor degree in Bioorganic Chemistry from the Institute of Physiologically Active Compounds.



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Rachelle Doody, M.D., Ph.D. Dr. Doody is the Effie Marie Cain Professor and Director of
Alzheimers Disease Research at the Alzheimers Disease and Memory Disorder Center at Baylor College of Medicine. Dr. Doody participated in the development of CIBIC-plus, one of the primary cognitive assessment endpoints that the FDA
has used for the currently approved Alzheimers drugs. Dr. Doody has worked on clinical studies for all of the FDA-approved cholinesterase drugs for Alzheimers disease. Dr. Doody received her M.D. from Baylor College of Medicine
and holds a M.A. and Ph.D. in Cognitive Anthropology from Rice University.

Michael E. Jung, Ph.D.Dr. Jung is a Distinguished
Professor of Chemistry at the University of California, Los Angeles, where his research focuses on the development of new synthetic methods and the total synthesis of biologically interesting natural products. Dr. Jung has authored more than
240 scientific publications, and is a named inventor on multiple issued patents and pending patent applications. He holds a B.A. from Rice University in Houston and a Ph.D. in Chemistry from Columbia University in New York City.

Benjamin Lewin, Ph.D. Dr. Lewin is the founding editor of Cell, a leading international journal in the field of biology and, until
1999, also served as the Chief Executive Officer of the publisher ofCell, Cell Press. Dr. Lewin holds a M.Sc. from the University of London, and a M.A. and a Ph.D. from the University of Cambridge. Dr. Lewin also has authored
multiple books and scientific publications in the field of genetics.

Marc A. Shuman, M.D. Dr. Shuman is Professor of Medicine
at the University of California, San Francisco, and Chief of Hematology and Director of the Prostate Cancer Program at the UCSF Comprehensive Cancer Center. Dr. Shuman also serves as Clinical Director of the California Institute for
Quantitative Biomedical Research. Dr. Shuman is a member of the American Society of Clinical Investigation and the Association of American Physicians, and has published extensively in the field of prostate cancer. Dr. Shuman received his
M.D. from the Thomas Jefferson Medical College and clinical training at the University of Pennsylvania and Washington University in St. Louis.

Roger Tung, Ph.D. Dr. Tung is the president and CEO of Concert Pharmaceuticals. He has more than twenty years of experience in scientific and scientific management positions at the Squibb Institute for Medical Research, Merck
Research Laboratories and Vertex Pharmaceuticals Incorporated. Prior to joining Concert, he served as Vice President, Drug Discovery, of Vertex Pharmaceuticals Incorporated. He discovered two of Vertexs currently marketed products, and is an
inventor on multiple issued U.S. patents. Dr. Tung holds a Ph.D. in Pharmaceutical Chemistry from the University of Wisconsin-Madison.

Employees

As of December 31, 2006, we had nine employees, all but one of whom were full-time.



|Item 2. | Description of Property.
|------- | ------------------------

We currently lease
approximately 5,700 square feet of office space located at 55 Hawthorne Street, Suite 610, San Francisco, California 94105 for all of our operations. The telephone number at our office is (415) 543-3470.



|Item 3. | Legal Proceedings.
|------- | ------------------

The company is not a party to
any pending legal proceedings.



|Item 4. | Submission of Matters to a Vote of Security Holders.
|------- | ----------------------------------------------------

No matter was submitted during the fourth quarter of the fiscal year ended December 31, 2006 to a vote of security holders through the solicitation of proxies or otherwise.



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PART II



|Item 5. | Market for Common Equity and Related Stockholder Matters.
|------- | ---------------------------------------------------------

Common Stock Prices

Our common stock began trading on the American Stock Exchange on March 15, 2006 under the symbol
MDV. Prior to that date, our common stock was quoted on the OTC Bulletin Board under the symbol MDVN. The following table sets forth on a per share basis the high and low bid prices of our common stock as reported on the OTC
Bulletin Board from January 1, 2005 through March 14, 2006, and the high and low sales prices of our common stock as reported on the American Stock Exchange from March 15, 2006 through December 31, 2006.



|                                  |  |      |       |     |   |     
|--------------------------------- |  | ---- | ----- | --- | - | ----
|                                  |  | High |       | Low
|Year ended December 31, 2005      |  |      |       |     |   |     
|First quarter                     |  | $    | 3.80  |     | $ | 1.50
|Second quarter                    |  | $    | 4.30  |     | $ | 3.00
|Third quarter                     |  | $    | 3.65  |     | $ | 2.05
|Fourth quarter                    |  | $    | 3.00  |     | $ | 1.80
|Year ended December 31, 2006      |  |      |       |     |   |     
|January 1, 2006 to March 14, 2006 |  | $    | 5.00  |     | $ | 2.40
|March 15, 2006 to March 31, 2006  |  | $    | 4.45  |     | $ | 3.83
|Second quarter                    |  | $    | 5.92  |     | $ | 3.80
|Third quarter                     |  | $    | 9.50  |     | $ | 3.95
|Fourth quarter                    |  | $    | 18.87 |     | $ | 9.00

According to the records of our transfer agent, American Stock Transfer & Trust Company,
as of February 16, 2007, we had 125 holders of record of common stock.

The source of the information provided in the table above for
period from January 1, 2005 through March 14, 2006 is the OTC Bulletin Board®,Trade and Quote Summary Report, and represents prices between dealers without adjustments for retail markups, markdowns or commissions, and may not represent actual transactions.

Recent Sales of Unregistered Securities

On
March 27, 2006, warrants for 7,742 shares of common stock were exercised on a cashless basis in exchange for 4,742 shares of common stock. On April 17, 2006, warrants for 316,645 shares of common stock were exercised on a cashless basis in
exchange for 214,395 shares of common stock. On November 27, 2006, warrants for 35,145 shares of common stock were exercised on a cashless basis in exchange for 31,414 shares of common stock. On December 19, 2006, warrants for 126,145
shares of common stock were exercised on a cashless basis in exchange for 114,288 shares of common stock. The exercises were effected in reliance on Section 3(a)(9) of the Securities Act.



|Item 6. | Managements Discussion and Analysis or Plan of Operation
|------- | ---------------------------------------------------------

The following discussion should be read in conjunction with our audited consolidated financial statements and notes thereto for the fiscal year ended December 31, 2006, included elsewhere in this Report. The
following Managements Discussion and Analysis or Plan of Operation contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of
1934. We intend that these forward-looking statements be subject to the safe harbors created by those provisions. Forward-looking statements are generally written in the future tense and/or are preceded by words such as may,
should, forecast, could, expect, suggest, believe, anticipate, intend, plan, or other similar words. The forward-looking statements contained
in this Report involve a number of risks and uncertainties, many of which are outside of our control. Factors that could cause actual results to differ materially from projected results include, but are not limited to, those discussed in Risk
Factors elsewhere in this Report. Readers are expressly advised to review and consider those Risk Factors, which include risks associated with (1) our ability to



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successfully conduct clinical and preclinical trials for our product candidates, (2) our ability to obtain required regulatory approvals to develop
and market our product candidates, (3) our ability to raise additional capital on favorable terms, (4) our ability to execute our development plan on time and on budget, and (5) our ability to identify and obtain additional product
candidates. Although we believe that the assumptions underlying the forward-looking statements contained in this Report are reasonable, any of the assumptions could be inaccurate, and therefore there can be no assurance that such statements will be
accurate. In light of the significant uncertainties inherent in the forward-looking statements included herein, the inclusion of such information should not be regarded as a representation by us or any other person that the results or conditions
described in such statements or our objectives and plans will be achieved. Furthermore, past performance in operations and share price is not necessarily indicative of future performance. We disclaim any intention or obligation to update or revise
any forward-looking statements, whether as a result of new information, future events or otherwise.

The Company

We are a biopharmaceutical company engaged in the acquisition, research and development of promising medical technologies. We focus particularly on
technologies that have strong intellectual property positions, address large unmet medical needs, and have the potential to enter clinical development within 12 to 18 months after acquisition, and on driving development in a rapid, cost-effective
manner. We intend to build and maintain a portfolio of four to six development programs at all times, and remain actively engaged in evaluation of new technologies to further expand our portfolio.

Our Current Portfolio

Our current portfolio
consists of small molecule drugs in development to treat three large, unmet medical needsDimebon for the treatment of Alzheimers disease, Dimebon for the treatment of Huntingtons disease, and MDV3100 for the treatment of hormone-refractory prostate cancer. Dimebon is a
small molecule drug that was approved in 1983 by the Russian Ministry of Health for use as an oral antihistamine. MDV3100 is the lead development candidate in a family of approximately 170 novel small molecules that we refer to as the MDV300 series
compounds.

Alzheimers Disease Program. Our proprietary small molecule Dimebon has been shown to inhibit the death of
brain cells (neurons) in preclinical models of Alzheimers disease and Huntingtons disease, making it a novel potential treatment for many neurodegenerative diseases. In September 2006, we announced that Dimebon met all five efficacy
endpoints in a six-month randomized, double-blinded, placebo-controlled Phase 2 trial of 183 patients with mild to moderate Alzheimers disease conducted at 11 sites in Russia. Patients in the trial were tested for a full spectrum of
problems typically caused by Alzheimers disease, including memory loss, behavioral disturbances, and inability to perform everyday activities such as bathing and dressing. After six months of treatment, Dimebon-treated patients scored
significantly better on all of these tests than did placebo-treated patients. Dimebon-treated patients also improved significantly over their own starting baseline scores on all of these tests. Dimebon also was well tolerated in this study.
Medivation and its advisors designed this study to match closely the design of pivotal registration studies previously accepted by the FDA to approve drugs to treat mild to moderate Alzheimers disease, including duration of treatment, clinical
endpoints and patient inclusion/exclusion criteria. Based on these results, we intend aggressively to pursue further development of Dimebon as a potential treatment for Alzheimers disease.

Huntingtons Disease Program. In October 2006, we began a U.S. Phase 1-2a clinical study of Dimebon in Huntingtons
disease patients, which we are conducting in collaboration with the Huntington Study Group. Our study design has two parts. Part A is an open-label dose escalation phase in which patients will be treated with increasing doses of Dimebon to
determine safety, tolerability, pharmacokinetics, and the recommended doses for Part B of the study. Part B is a randomized, double-blinded, placebo-controlled phase in which approximately 75 patients will be treated for a period of 90 days to
further evaluate the safety and preliminary efficacy of Dimebon as a treatment for Huntingtons disease. We expect Part B of the study to begin in the first half of 2007, after the FDA has reviewed the results of additional animal
toxicology studies it required us to complete.



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Hormone-Refractory Prostate Cancer Program. Our MDV300 series compounds are in development
for the treatment of HRPC. In the first half of 2007 we expect to begin a Phase 1-2a clinical study of our lead compound, MDV3100, in HRPC patients. Our proposed study design is an open-label dose-escalation trial with each patient continuing on
MDV3100 for at least three months in the absence of a significant safety issue or disease progression. In addition, 20 subjects will be enrolled and treated with the maximum-tolerated dose for at least 90 days to further evaluate the safety,
tolerability and preliminary efficacy of MDV3100 as a treatment for HRPC. Patients serum levels of PSA, a frequently-used surrogate marker of prostate cancer progression, will be measured regularly in the study. Patients will be given the
option in certain circumstances to continue treatment for longer periods of time.

Our Current Development Plan

Our current development plan for our Alzheimers disease, Huntingtons disease and HRPC programs, and the presently estimated timeline for each
development milestone, are as follows:



|                                    |  |                                                         |  |                |  |                
|----------------------------------- |  | ------------------------------------------------------- |  | -------------- |  | ---------------
|Program                             |  | Development Milestone                                   |  | EstimatedStart |  | EstimatedFinish
|Alzheimers disease:                |  | Phase 2 twelve-month efficacy trial (Russia)            |  | In progress    |  | Q2 2007        
|                                    |  | Phase 1 clinical trial (U.S.)                           |  | 1H 2007        |  | 2H 2007        
|                                    |  | Phase 2 dose finding clinical trial (U.S.)              |  | 2H 2007        |  | 2008           
|                                    |  | Phase 3 clinical trials (global)                        |  | 2008           |  | 2010           
|                                    |  | Apply for U.S. and European marketing approval          |  | 2010           |  | n/a            
|Huntingtons disease:               |  | Phase 1-2a* clinical trial, Part A (U.S.)               |  | In progress    |  | 1H 2007        
|                                    |  | Phase 1-2a* clinical trial, Part B (U.S.)               |  | 1H 2007        |  | 2H 2007        
|                                    |  | Phase 3 clinical trials (global)                        |  | 2008           |  | 2009           
|                                    |  | Apply for U.S. and European marketing approval          |  | 2009           |  | n/a            
|Hormone-refractory prostate cancer: |  | Phase 1-2a* clinical trial (U.S.)                       |  | 1H 2007        |  | 2008           
|                                    |  | Report efficacy data from the first subset of patients  |  | 2H 2007        |  | n/a            
|                                    |  | Determine whether to proceed to Phase 3 clinical trials |  | 2008           |  | n/a            

---

|* | As used in this Report, a Phase 1-2a clinical study is one conducted in patients with the applicable disease and that includes at least one efficacy endpoint.
|- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------

Because of Dimebons prior history of human use in Russia, the Russian Ministry of Health allowed us to proceed
directly to a large efficacy study with the same duration of treatment and clinical endpoints accepted by the FDA to approve drugs for mild to moderate Alzheimers disease. Taking this approach allowed us to generate risk-reducing data on the
safety and efficacy of Dimebon in Alzheimers disease patients sooner than would have been possible under a more conventional drug development pathway, in which a sponsor typically would complete Phase 1 and Phase 2 dose finding
studies before beginning large efficacy studies. With respect to subsequent Alzheimers disease clinical trials, however, our current clinical development plan assumes that we will follow the more conventional drug development pathway and
complete Phase 1 and Phase 2 dose finding studies before starting Phase 3 clinical trials. In Huntingtons disease and HRPC, by contrast, we expect to proceed directly to Phase 3 clinical trials in those indications if our
Phase 1-2a clinical trials are positive.

Based on presently available information, our management believes that achievement of the
above development milestones relating to our existing product candidates by the estimated dates set forth above is a reasonably achievable goal. However, both our proposed development milestones and their estimated start and finish dates are
forward-looking statements, and as such are subject to significant risk and uncertainty. We caution you that the development of biomedical product candidates like ours is subject to high levels of risk, including risks presented by subsequent
developments that are unforeseen or unforeseeable, as well as risks that are entirely outside of our control, including the risk of unfavorable results in any of our ongoing or planned



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preclinical and clinical studies. We also caution you that we have not yet received clearance from the FDA or any comparable foreign regulatory agencies to
begin any of the clinical trials listed above, except for the ongoing extension phase of our Russian Phase 2 efficacy study in Alzheimers disease and Part A of our ongoing U.S. Phase 1-2a clinical trial in Huntingtons disease.
We thus face the risk that the FDA and/or comparable foreign regulatory agencies will deny, or impose burdensome conditions on, our requests to begin any of our proposed clinical studies, or require us to conduct additional studies not listed above.
We thus cannot guarantee that we will be able to complete any of our projected milestone events, or that any of them that we do achieve will be on time or on budget.

Liquidity and Capital Resources

We have incurred aggregate net losses of $28,456,571 through
December 31, 2006, and we expect to incur substantial and increasing additional losses in the future as we expand our research and development activities, particularly the conduct of preclinical and clinical studies, increase our headcount and
seek to expand our clinical development portfolio.

In particular, based on the positive Phase 2 Alzheimers disease clinical
trial results we reported in September 2006, we have accelerated and significantly expanded our research and development work on Dimebon beginning in the fourth quarter of 2006. Reflecting this expansion, total operating expenses increased to
$6,165,863 in the fourth quarter of 2006 from $3,702,339 in the third quarter, an increase of $2,463,524 (or 67%). Of this increase, $1,867,928 (or 76%) was attributable to increased cash operating expenses, and the remaining $595,596 (or 24%) was
attributable to increased stock-based compensation, a non-cash expense. The increase in cash operating expense was due primarily to increased preclinical and clinical study expenses, which increased by $1,261,917 (or 64%) to $3,232,010 in the fourth
quarter of 2006 from $1,970,093 in the prior quarter. We expect cash operating expenses in 2007 to increase further beyond fourth quarter 2006 levels as we continue to expand our Dimebon research and development activities, begin our planned
Phase 1-2a clinical trial of MDV3100 in HRPC, and increase our headcount to staff these activities.

We have not generated any revenue
from operations to date, and do not expect to generate operating revenue for several years, if ever. All of our operations to date have been funded through the sale of our debt and equity securities, and we expect this to continue to be the case for
the foreseeable future.

As of December 31, 2006, we had cash, cash equivalents and short-term investments of $47,183,592, accounts
payable and other current liabilities of $1,739,614, and no long-term debt. We expect that our current cash, cash equivalents and short term investments will be sufficient to fund the presently budgeted costs of executing our development plan
through our planned initiation of global Phase 3 clinical trials of Dimebon in Alzheimers disease and Huntingtons disease in 2008, as described above. However, we caution you that this is a forward-looking statement and is subject
to significant risk and uncertainty, and that we may require additional financing sooner than expected for any of a number of reasons, including without limitation if we were to incur significant delays or cost overruns in the execution of our
development plan or if we were to expand our portfolio to include new product development programs.

We do not expect to purchase or sell
any plant or significant equipment for the foreseeable future.

Risk Factors

Our business and prospects are subject to the following material risks described below. The risks and uncertainties described below are not the only ones
we face. Additional risks and uncertainties not presently known to us, or that we currently believe to be immaterial, may also adversely affect our business.

Risks Related to our Business

We have incurred net losses since inception, expect to incur
increasingly large losses in the future as we expand our development activities, and may never achieve revenues or profitability.We are a development stage



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company and have never recognized any revenue from the sale of products or any other source. We have not completed development of any of our product
candidates, and do not expect that any of our present or future product candidates will be commercially available for a number of years, if at all. We have incurred losses since inception and expect to continue to incur substantial and increasing
losses for the foreseeable future as we increase our spending to finance clinical and preclinical studies of our existing product candidates, the evaluation, acquisition and development of additional product candidates, additional headcount, and the
costs associated with operating as a public company. Our operating losses have had, and will continue to have, an adverse impact on our working capital, total assets and stockholders equity. We do not know when or if we will ever generate
revenue or become profitable because of the significant uncertainties with respect to our ability to generate revenue from any of our current or future product candidates.

Because we depend on financing from third parties for our operations, our business may fail if such financing becomes unavailable or is offered on
commercially unreasonable terms.To date, we have financed all of our operations through borrowings and the sale of our equity securities. We will require significant additional capital to develop our existing product candidates, and to acquire
and develop other product candidates. Our future capital requirements will depend on many factors, including:



| |  |  | the scope and results of our preclinical and clinical trials;
| | - |  | -------------------------------------------------------------



| |  |  | whether we experience delays in our preclinical and clinical development programs, or slower than anticipated product development;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | whether we identify other product candidates that we wish to acquire, and the costs of acquiring and developing those product candidates;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------



| |  |  | whether we are able to enter into collaborative partnerships with regard to any of our product candidates, and the terms of any such collaboration;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the timing and requirements of, and the costs involved in, conducting studies required to obtain regulatory approvals for our product candidates from the FDA and
comparable foreign regulatory agencies;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | as necessitated by our business model, the availability of third parties to perform the key development tasks on our product candidates, including conducting
preclinical and clinical studies and manufacturing the products to be tested in those studies, and the associated costs of those services;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the availability and cost of raw materials required to manufacture products for testing in our preclinical and clinical studies; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs involved in preparing, filing, prosecuting, maintaining, defending the validity of, and enforcing, patent claims and other patent-related costs, including
litigation costs and the results of such litigation.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We may not be able to obtain additional financing when we need it
on acceptable terms or at all. If we cannot raise funds on acceptable terms, we may not be able to develop or enhance our product candidates, acquire or develop additional product candidates or respond to competitive pressures or unanticipated
requirements. For these reasons, any inability to raise additional capital when we require it would seriously harm our business.

Our
business strategy depends on our ability to identify and acquire additional product candidates which we may never acquire or identify for reasons that may not be in our control, or are otherwise unforeseen or unforeseeable to us. A key component
of our business strategy is to diversify our product development risk by identifying, acquiring and developing additional product candidates, whether drugs or medical devices. However, we may not be able to identify other promising technologies. In
addition, the competition to acquire promising biomedical technologies is fierce, and many of our competitors are large, multinational pharmaceutical, biotechnology and medical device companies with considerably more financial, development and
commercialization



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resources and experience than we have. Thus, even if we succeed in identifying promising technologies, we may not be able to acquire rights to them on
acceptable terms or at all. If we are unable to identify and acquire new technologies, we will be unable to diversify our product risk. We believe that any such failure would have a significant negative impact on our prospects because the risk of
failure of any particular development program in the pharmaceutical and medical device fields, including that of our existing programs, is high.

Because we depend on our management to oversee the execution of development plans for our existing product candidates and to identify and acquire promising new product candidates, the loss of any of our managers would harm our business.Our future success depends upon the continued services of our executive officers. We are particularly dependent on the continued services of David Hung, M.D., our President and Chief Executive Officer and a member of our board of directors.
Dr. Hung identified all of our existing product candidates for acquisition, and has primary responsibility for identifying and evaluating other potential product candidates. We believe that Dr. Hungs services in this capacity would
be difficult to replace. None of our executive officers is bound by an employment agreement for any specific term, and they may terminate their employment at any time. In addition, we do not have key person life insurance policies
covering any of our executive officers. The loss of the services of any of our executive officers could delay the development of our existing product candidates, and delay or preclude the identification and acquisition of new product candidates,
either of which events could harm our business.

Our reliance on third parties for the operation of our business may result in material
delays, cost overruns and/or quality deficiencies in our development programs.We rely on outside vendors to perform key product development tasks, such as conducting preclinical and clinical studies and manufacturing the product candidates to
be tested in those studies. In order to manage our business successfully, we will need to identify, engage and properly manage qualified external vendors who will perform these development activities. For example, we need to monitor the activities
of our vendors closely to ensure that they are performing their tasks correctly, on time, on budget and in compliance with strictly-enforced regulatory standards. Our ability to identify and retain key vendors with the requisite knowledge is
critical to our business and the failure to do so could have a material adverse impact on our business. Because all of our key vendors perform services for other clients in addition to us, we also need to ensure that they are appropriately
prioritizing our projects. If we fail to manage our key vendors well, we could incur material delays, cost overruns or quality deficiencies in our development programs, as well as other material disruptions to our business.

Risks Related to our Product Development Candidates

Our product candidates require extensive, time consuming and expensive preclinical and clinical testing to establish safety and efficacy. We may never attract partners for our technologies or receive marketing
approval in any jurisdiction.The research and development of pharmaceuticals and medical devices is an extremely risky industry. Only a small percentage of product candidates that enter the development process ever receive marketing approval.
Except for Dimebons approval in Russia as an antihistamine, which is not a commercially attractive opportunity for us, none of our product candidates is currently approved for sale anywhere in the world, and none of them may ever receive such
approval. Furthermore, none of our product candidates other than Dimebon has yet been tested in humans. The process of conducting the preclinical and clinical testing required to establish safety and efficacy and obtain marketing approval is
expensive, uncertain and takes many years. If we are unable to complete preclinical or clinical trials of any of our current or future product candidates, or if the results of these trials are not satisfactory to convince regulatory authorities or
potential partners of their safety or efficacy, we will not be able to attract partners or obtain marketing approval for any products. Furthermore, even if we or our potential partners are able to obtain marketing approvals for any of our product
candidates, those approvals may be for indications that are not as broad as desired, or may contain other limitations that would adversely affect our ability to generate revenue from sales of those products. If this occurs, our business will be
materially harmed and our ability to generate revenue will be severely impaired.



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Positive results in any of our early- and mid-stage clinical trials, including our Phase 2
clinical trial of Dimebon in Alzheimers disease, may not be predictive of future clinical trial results.Even where we achieve positive results in early- or mid-stage clinical trials, including our Phase 2 clinical trial of Dimebon in
Alzheimers disease, we cannot predict whether the results of later-stage clinical trials will be positive because product candidates in later stages of clinical trials often fail to show the desired safety and efficacy traits despite having
progressed successfully through prior stages of preclinical and clinical testing.

Our industry is highly regulated by the U.S. Food and
Drug Administration (FDA) and comparable foreign regulatory agencies. We must comply with extensive, strictly-enforced regulatory requirements in order to develop and seek marketing approval for any of our product candidates.Before we or our
potential partners can obtain regulatory approval for the sale of our product candidates, they must be subjected to extensive preclinical and clinical testing to demonstrate their safety and efficacy for humans. The preclinical and clinical trials
of any product candidates that we develop must comply with regulation by numerous federal, state and local government authorities in the U.S., principally the FDA, and by similar agencies in other countries. In the case of our pharmaceutical product
candidates, we will be required to obtain and maintain an effective investigational new drug application to conduct human clinical trials in the U.S. and must obtain and maintain regulatory approval before proceeding to successive phases of our
clinical trials. Similar regulatory requirements apply to medical devices, and may become relevant to us should we acquire any medical device product candidates. Securing FDA approval requires the submission of extensive preclinical and clinical
data and supporting information for each therapeutic indication to establish the product candidates safety and efficacy for its intended use. It takes years to complete the testing of a new drug or medical device, and development delays and/or
failure can occur at any stage of testing. For example, in February 2006 the FDA required us to conduct additional rat toxicology studies in order to proceed with our Phase 1-2a clinical trial of Dimebon in Huntingtons disease
patients, which requirement increased development costs and slowed development. Similarly, any of our present and future clinical trials may be delayed or halted due to any of the following:



| |  |  | any preclinical test or clinical trial may fail to produce safety and efficacy results satisfactory to the FDA or foreign regulatory authorities;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | preclinical and clinical data can be interpreted in different ways, which could delay, limit or prevent regulatory approval;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | negative or inconclusive results from a preclinical test or clinical trial or adverse medical events during a clinical trial could cause a preclinical study or
clinical trial to be repeated or a program to be terminated, even if other studies or trials relating to the program are successful;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDA or foreign regulatory authorities can place a clinical hold on a trial if, among other reasons, it finds that patients enrolled in the trial are or would be
exposed to an unreasonable and significant risk of illness or injury;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDA might not approve the clinical processes or facilities that we utilize, or the processes or facilities of our consultants, including without limitation the
vendors who will be manufacturing drug substance and drug product for us or any potential collaborators;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | any regulatory approval we or any potential collaborators ultimately obtain may be limited or subject to restrictions or post-approval commitments that render the
product not commercially viable; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we may encounter delays or rejections based on changes in FDA policies or the policies of foreign regulatory authorities during the period in which we develop a
drug or the period required for review of any new drug application.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Enrollment of patients in clinical trials is
often an expensive and time-consuming process, and could result in significant delays, cost overruns, or both, in our product development activities.We may encounter delays in enrolling a sufficient number of patients to complete our clinical
trials. Patient enrollment depends on many factors, including the size of the patient population, the nature of the trial protocol, the proximity of patients to



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clinical sites and the eligibility criteria for the study. In particular, we intend to conduct monotherapy studies of Dimebon in Alzheimers
disease patients  studies in which patients in the placebo group do not receive treatment with any approved Alzheimers disease drugs. Because approved Alzheimers disease drugs are widely available in the U.S. and Europe, we believe
that patient accrual in Dimebon monotherapy studies will be particularly time-consuming. Delays in planned patient enrollment may result in increased costs, program delays or both, which could have a harmful effect on our ability to develop Dimebon
or any other product candidates. In addition, if we are delayed in reaching, or are unable to reach, product development milestones we may be unable to comply with requirements in our present and future license agreements, which could result in
partial or total loss of our license rights.

We have not yet sold or partnered any of our product development candidates with third
party collaborators, and we cannot control whether we will be able to do so on favorable terms or at all.Our business strategy relies in part on potentially selling or partnering successful product development candidates with larger
pharmaceutical, biotechnology or medical device companies for late-stage clinical trials and/or commercialization. For example, because Alzheimers disease is a large market requiring a large sales force, we expect to seek a commercial partner
for Dimebon in that indication. We may also be required to enter into collaborative relationships to complement our internal efforts, whether in research and development, manufacturing or commercialization, and/or to generate necessary financing. We
have not entered into any such sales or collaborations to date. It may be difficult for us to find third parties that are willing to enter into such transactions on acceptable economic terms or at all. We also will be competing with many other
companies as we seek partners for our product candidates, and we may not be able to compete successfully against those other firms. If we are not able to enter into sales or collaboration transactions for our product development candidates, we would
be required to undertake and fund further development, clinical trials, manufacturing and marketing activities solely at our own expense and risk. If we are unable to finance those expensive activities, we would have to substantially reduce our
development efforts and our business and prospects would be materially and adversely harmed for that reason.

If we enter into sales or
collaboration transactions, we will be dependent upon our partners, and we may be unable to prevent them from taking actions that may be harmful to our business or inconsistent with our business strategy.Any sales or collaboration agreements we
may enter into with respect to our product development candidates are likely to provide us with little or no control over the activities of our partners. For example, future partners, if any, are likely to have the right to terminate the
collaboration at their option. Our partners may decide to terminate a development program under circumstances where we might have continued such a program, or may be unable or unwilling to pursue ongoing development and commercialization activities
as quickly as we would prefer. Any partner may be unwilling or unable to fulfill its obligations to us, including its development and commercialization responsibilities in respect of our product candidates. Our partners will likely have significant
discretion in determining the efforts and level of resources that they dedicate to the development and commercialization of our product candidates. In addition, our collaborators may develop and commercialize, either alone or with others, products
and services that are similar to or competitive with the products that are the subject of the collaboration with us.

We expect that the
financial returns to us in any sale or collaboration agreement would depend in large part on the achievement of development and/or commercialization milestones on, and royalties, co-promotion fees or other payments based upon sales of, our product
candidates. Therefore, our success, and any associated financial returns to us and our investors, will depend on the ability of any of our future collaborators to obtain and maintain regulatory approvals from the FDA and other foreign regulatory
agencies and commercialize our product candidates. We may also be dependent on our collaborators for the commercial scale manufacture, distribution, sales, marketing and reimbursement of our product candidates. These collaborators may not be
successful. If any future collaborator terminates its collaboration with us or fails to perform or satisfy its obligations to us, the development, regulatory approval or commercialization of our product candidate would be delayed or may not occur
and our business and prospects would be materially and adversely affected for that reason.



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If our product candidates cannot be manufactured in a cost-effective manner and in compliance with
current good manufacturing practices and other applicable regulatory standards, they will not be commercially successful. All pharmaceutical and medical device products in the U.S., Europe and other countries must be manufactured in strict
compliance with current good manufacturing practices (GMP) and other applicable regulatory standards. Establishing a GMP-compliant process to manufacture pharmaceutical and medical device products involves significant time, cost and uncertainty.
Furthermore, in order to be commercially viable, any such process would have to yield product on a cost-effective basis, using raw materials that are commercially available on acceptable terms. We have manufactured Dimebon in the U.S. under a
GMP-compliant process for use in our preclinical and initial clinical studies in the U.S. The manufacturing process we used, which is based on the process used in Russia, uses a chemical that is hazardous to handle, difficult to source and expensive
to process. We will need to refine our manufacturing process to avoid use of this chemical in order to manufacture Dimebon at commercial-scale on a cost-effective basis. This process development and associated scale-up work is currently underway,
and we expect it to be completed in time to support our goal of starting global Phase 3 studies in Alzheimers disease and Huntingtons disease in 2008. However, we cannot guarantee that we will be able to complete this work in a
timely manner or at all. Furthermore, neither Dimebon nor MDV3100 has been manufactured at commercial-scale under GMP-compliant conditions. We thus face the risk that commercial-scale GMP manufacture of Dimebon and/or MDV3100 would not be possible,
on a cost-effective basis or at all, which would materially and adversely affect the value of these programs.

Any of our product
development candidates that receive marketing approval will face significant competition from other approved products and other products in development.The drug and medical device development markets are intensely competitive in general.
Furthermore, our business strategy is to target large unmet medical needs, and those markets are even more highly competitive. For example, there are four drugs commonly used in the U.S. to treat Alzheimers disease, and these drugs all target
at least one of the same mechanisms as does Dimebon. In addition, these Alzheimers disease drugs are all dosed once or twice per day, while Dimebon was dosed three times per day in our Phase 2 clinical trial. This difference in dosing
regimen may make Dimebon less competitive than alternative Alzheimers disease drugs if Dimebon receives marketing approval based on a thrice per day dosing regimen. Companies marketing currently-approved Alzheimers disease therapeutics
include some of the worlds largest and most experienced pharmaceutical companies, such as Pfizer Inc., Novartis AG and Johnson & Johnson. There are also dozens of additional small molecule and recombinant protein candidates in
development targeting the clinical indications we are pursuing, particularly Alzheimers disease and HRPC. One or more such compounds may be approved in each of our target indications before any of our product candidates could potentially be
approved. Most, if not all, of these competing drug development programs are being conducted by pharmaceutical and biotechnology companies with considerably greater financial resources, human resources and experience than ours. Bases upon which our
product candidates would have to compete successfully include efficacy, safety, price and cost-effectiveness. In addition, our product candidates would have to compete against these other drugs with several different categories of decision
makersincluding physicians, patients, government and private third-party payors, technology assessment groups and patient advocacy organizations. Even if one of our product candidates is approved, we cannot guarantee that we or any of our
future partners will be able to compete successfully on any of these bases. Any future product candidates that we may subsequently acquire will face similar competitive pressures. If we or any of our future partners cannot compete successfully on
any of the bases described above, our business will not succeed.

Any of our product candidates that is eventually approved for sale may
not be commercially successful if not widely-covered and appropriately reimbursed by third-party payors.Third-party payors, including public insurers such as Medicare and Medicaid and private insurers, pay for a large share of health care
products and services consumed in the U.S. In Europe, Canada and other major international markets, third-party payors also pay for a significant portion of health care products and services, and certain of those countries have nationalized health
care systems in which the government pays for all such products and services. Even if approved by the FDA and other regulatory agencies, our product candidates are unlikely to achieve commercial success unless they are covered widely by third-party
payors and reimbursed at a rate which generates an acceptable commercial



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return for us and any collaborative partner. It is increasingly difficult to obtain coverage and acceptable reimbursement levels from third-party payors, and
we may be unable to achieve these objectives. Achieving coverage and acceptable reimbursement levels typically involves negotiating with individual payors, and is a time-consuming and costly process. In addition, we would face competition in such
negotiations from other approved drugs against which we compete, and the marketers of such other drugs are likely to be significantly larger than us and therefore enjoy significantly more negotiating leverage. Failure to achieve coverage and
acceptable reimbursement levels could harm our business.

We may be subject to product liability or other litigation, which could result
in an inefficient allocation of our critical resources, delay the implementation of our business strategy and, if successful, materially and adversely harm our business and financial condition as a result of the costs of liabilities that may be
imposed thereby.Our business exposes us to the risk of product liability claims that is inherent in the development of drugs and medical devices. If any of our product candidates harms people, or is alleged to be harmful, we may be subject to
costly and damaging product liability claims brought against us by clinical trial participants, consumers, health care providers, pharmaceutical companies or others. We have product liability insurance covering our ongoing clinical trials, but do
not have insurance for any of our other development activities. If we are unable to obtain insurance at an acceptable cost or otherwise protect against potential product liability claims, we may be exposed to significant litigation costs and
liabilities, which may materially and adversely affect our business and financial position. If we are sued for injuries allegedly caused by any of our product candidates, our litigation costs and liability could exceed our total assets and our
ability to pay. In addition, we may from time to time become involved in various lawsuits and legal proceedings which arise in the ordinary course of our business. Any litigation to which we are subject could require significant involvement of our
senior management and may divert managements attention from our business and operations. Litigation costs or an adverse result in any litigation that may arise from time to time may adversely impact our operating results or financial
condition.

Risks Related to Intellectual Property

Intellectual property protection for our product candidates is crucial to our business, and is subject to a significant degree of legal
riskparticularly in the life sciences industry.The success of our business will depend in part on our obtaining and maintaining intellectual property protectionprimarily patent protectionof our technologies and product
candidates, as well as successfully defending these patents against third-party challenges. We and our potential future collaborators will only be able to protect our technologies and product candidates from unauthorized use by third parties to the
extent that valid and enforceable patents or trade secrets cover them. Furthermore, the degree of future protection of our proprietary rights is uncertain because legal means afford only limited protection and may not adequately protect our rights
or permit us or our potential future collaborators to gain or keep our competitive advantage.

The patent positions of life sciences
companies can be highly uncertain and involve complex legal and factual questions for which important legal principles remain unresolved. Further, changes in either the patent laws or in interpretations of patent laws in the U.S. or other countries
may diminish the value of our intellectual property. Accordingly, we cannot predict the breadth of claims that may be granted or enforced in our patents or in third-party patents that we have licensed. For example:



| |  |  | we or our licensors might not have been the first to make the inventions covered by each of our pending patent applications and issued patents;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we or our licensors might not have been the first to file patent applications for these inventions;
| | - |  | ---------------------------------------------------------------------------------------------------



| |  |  | others may independently develop similar or alternative technologies or duplicate any of our technologies;
| | - |  | ----------------------------------------------------------------------------------------------------------



| |  |  | it is possible that none of our pending patent applications or the pending patent applications of our licensors will result in issued patents;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | our issued patents and future issued patents, or those of our licensors, may not provide a basis for commercially viable products, may not provide us with any
competitive advantages, or may be challenged by third parties and invalidated; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we may not develop additional proprietary technologies or product candidates that are patentable.
| | - |  | -------------------------------------------------------------------------------------------------

Our existing and any future patent rights may not adequately protect any of our product candidates, which could prevent us from ever generating any
revenues or profits.We cannot guarantee that any of our pending or future patent applications will mature into issued patents, or that any of our current or future issued patents will adequately protect our product candidates from competitors.
For example, there is a large body of prior art, including multiple issued patents and published patent applications, disclosing molecules in the same chemical class as our MDV300 series compounds. Since our MDV300 series compounds include
approximately 170 specific molecules, we expect that some members of this series may not be patentable in light of this prior art, or may infringe the claims of patents presently issued or issued in the future. Furthermore, we also cannot guarantee
that any of our present or future issued patents will not be challenged by third parties, or that they will withstand any such challenge. If we are not able to obtain adequate protection for, or defend, the intellectual property position of our
technologies and product candidates, then we may not be able to attract collaborators to acquire or partner our development programs. Further, even if we can obtain protection for and defend the intellectual property position of our technologies and
product candidates, we or any of our potential future collaborators still may not be able to exclude competitors from developing or marketing competing drugs. Should this occur, we and our potential future collaborators may not generate any revenues
or profits from our product candidates.

We could become subject to litigation or other challenges regarding intellectual property
rights, which could divert management attention, cause us to incur significant costs, prevent us from selling or using the challenged technology and/or subject us to competition by lower priced generic products.In recent years, there has been
significant litigation in the U.S. and elsewhere involving pharmaceutical patents and other intellectual property rights. In particular, generic pharmaceutical manufacturers have been very aggressive in attacking the validity of patents held by
proprietary pharmaceutical companies, especially if these patents are commercially significant. If any of our present or future product candidates succeeds, we may face challenges to our existing or future patents. For example, in the prosecution of
our issued U.S. patent claiming the use of Dimebon and certain related compounds to treat neurodegenerative diseases, the prior owners missed a filing deadline with the U.S. Patent & Trademark Office (PTO), which resulted in the patent
application being deemed abandoned. The prior owners petitioned the PTO to revive the patent application alleging that missing the deadline was unintentional, and the PTO approved the petition and issued the patent. However, as with any other
decision the PTO makes, this decision could be challenged in subsequent litigation in an attempt to invalidate this issued U.S. patent and any other U.S. patent that may issue based on the same patent application.If a generic pharmaceutical
company or other third party were able to successfully invalidate any of our present or future patents, any of our product candidates that may ultimately receive marketing approval could face additional competition from lower priced generic products
that would result in significant price and revenue erosion and have a material adverse impact on the commercial viability of the affected product candidate(s).

In the future, we may be a party to litigation to protect our intellectual property or as a result of an alleged infringement of others intellectual property. These claims and any resulting lawsuit, if
successful, could subject us to significant liability for damages and invalidation, or a narrowing of the scope, of our proprietary rights. These lawsuits, regardless of their success, would likely be time-consuming and expensive to litigate and
resolve and would divert management time and attention. Any potential intellectual property litigation also could force us to do one or more of the following:



| |  |  | discontinue our products that use the challenged intellectual property; or
| | - |  | --------------------------------------------------------------------------



| |  |  | obtain from the owner of the infringed intellectual property right a license to sell or use the relevant technology, which license may not be available on
reasonable terms, or at all.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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If we are forced to take any of these actions, our business may be seriously harmed. Although we carry
general liability insurance, our insurance does not cover potential claims of this type.

In addition, our patents and patent applications,
or those of our licensors, could face other challenges, such as interference proceedings, opposition proceedings and re-examination proceedings. Any such challenge, if successful, could result in the invalidation of, or in a narrowing of the scope
of, any such patents and patent applications. Any such challenges, regardless of their success, would likely be time-consuming and expensive to defend and resolve, and would divert management time and attention.

We may in the future initiate claims or litigation against third parties for infringement of our proprietary rights to protect these rights or to
determine the scope and validity of our proprietary rights or the proprietary rights of competitors. These claims could result in costly litigation and the diversion of our technical and management personnel, and we may not prevail in making these
claims.

We may need to obtain licenses of third-party technology that may not be available to us or are available only on commercially
unreasonable terms, and which may cause us to operate our business in a more costly or otherwise adverse manner that was not anticipated.From time to time we may be required to license technology from third parties to develop our existing and
future product candidates. For example, in our industry there are a large number of issued patents and published patent applications with claims to treating diseases generically through use of any product that produces one or more biological
activitiessuch as inhibiting a specific biological target. We are aware of several such issued patents relating to Alzheimers disease, and expect to continue to encounter such patents relating to other diseases targeted by our present
and future product candidates. We have not conducted experiments to analyze whether, and we have no evidence that, any of our product candidates produce the specific biological activities covered in any of the issued patents or published patent
applications of which we are presently aware. We have not sought to acquire licenses to any such patents. In addition, we have not yet developed commercial-scale manufacturing processes for any of our product candidates, and any such processes that
we develop may require licenses to third party technology. Should we be required to obtain licenses to any third-party technology, including any such patents based on biological activities or required to manufacture our product candidates, such
licenses may not be available to us on commercially reasonable terms, or at all. The inability to obtain any third-party license required to develop any of our product candidates could cause us to abandon any related development efforts, which could
seriously harm our business and operations.

We may become involved in disputes with potential future collaborators over intellectual
property ownership, and publications by our research collaborators and scientific advisors could impair our ability to obtain patent protection or protect our proprietary information, which, in either case, could have a significant impact on our
business.Inventions discovered under research, material transfer or other such collaborative agreements may become jointly owned by us and the other party to such agreements in some cases, and the exclusive property of either party in other
cases. Under some circumstances, it may be difficult to determine who owns a particular invention, or whether it is jointly owned, and disputes could arise regarding ownership of those inventions. These disputes could be costly and time consuming,
and an unfavorable outcome could have a significant adverse effect on our business if we were not able to protect or license rights to these inventions. In addition, our research collaborators and scientific advisors generally have contractual
rights to publish our data and other proprietary information, subject to our prior review. Publications by our research collaborators and scientific advisors containing such information, either with our permission or in contravention of the terms of
their agreements with us, may impair our ability to obtain patent protection or protect our proprietary information, which could significantly harm our business.

Trade secrets may not provide adequate protection for our business and technology.We also rely on trade secrets to protect our technology, especially where we believe patent protection is not appropriate or
obtainable. However, trade secrets are difficult to protect. While we use reasonable efforts to protect our trade secrets, our or our potential collaborators employees, consultants, contractors or scientific and other advisors may



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unintentionally or willfully disclose our information to competitors. If we were to enforce a claim that a third party had illegally obtained and was using
our trade secrets, our enforcement efforts would be expensive and time consuming, and the outcome would be unpredictable. In addition, courts outside the U.S. are sometimes less willing to protect trade secrets. Moreover, if our competitors
independently develop equivalent knowledge, methods or know-how, it will be more difficult or impossible for us to enforce our rights and our business could be harmed.

Risks Related to Ownership of our Common Stock

Our stock price may be volatile, and our
stockholders investment in our stock could decline in value.The market prices for our securities and those of other life sciences companies have been highly volatile and may continue to be highly volatile in the future. The following
factors, in addition to other risk factors described in this Report, may have a significant impact on the market price of our common stock:



| |  |  | the receipt or failure to receive the additional funding necessary to conduct our business;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | the progress and success of preclinical studies and clinical trials of our product candidates conducted by us or our future collaborative partners or licensees, if
any;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | selling by large stockholders;
| | - |  | ------------------------------



| |  |  | announcements of technological innovations or new commercial products by our competitors or us;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | developments concerning proprietary rights, including patents;
| | - |  | --------------------------------------------------------------



| |  |  | developments concerning any future collaborations;
| | - |  | --------------------------------------------------



| |  |  | publicity regarding actual or potential medical results relating to products under development by our competitors or us;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | regulatory developments in the United States and foreign countries;
| | - |  | -------------------------------------------------------------------



| |  |  | litigation;
| | - |  | -----------



| |  |  | economic and other external factors or other disaster or crisis; and
| | - |  | --------------------------------------------------------------------



| |  |  | period-to-period fluctuations in financial results.
| | - |  | ---------------------------------------------------

We do not intend to pay regular dividends on our common stock for the foreseeable future.We do not expect for the foreseeable future to pay regular dividends on our common stock. Any future determination to
pay dividends on or repurchase shares of our common stock will be at the discretion of our board of directors and will depend upon, among other factors, our success in completing sales or partnerships of our programs, our results of operations,
financial condition, capital requirements, contractual restrictions and applicable law.

Our principal stockholders exert substantial
influence over us and may exercise their control in a manner adverse to your interests.Certain stockholders and their affiliates own a substantial amount of our outstanding common stock. Please refer to Item 11: Security Ownership of
Certain Beneficial Owners and Management and Related Stockholder Matters for more information. These stockholders may have the power to direct our affairs and be able to determine the outcome of certain matters submitted to stockholders for
approval. Because a limited number of persons controls us, transactions could be difficult or impossible to complete without the support of those persons. Subject to applicable law, it is possible that these persons will exercise control over us in
a manner adverse to your interests.

Provisions of our charter documents, our stockholder rights plan and Delaware law could make it
more difficult for a third party to acquire us, even if the offer may be considered beneficial by our stockholders.Provisions of the Delaware General Corporation Law could discourage potential acquisition proposals and could
delay, deter or prevent a change in control. The anti-takeover provisions of the Delaware General Corporation



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Law impose various impediments to the ability of a third party to acquire control of us, even if a change in control would be beneficial to our existing
stockholders. In addition, Section 203 of the Delaware General Corporation Law, unless its application has been waived, provides certain default anti-takeover protections in connection with transactions between the company and an
interested stockholder of the company. Generally, Section 203 prohibits stockholders who, alone or together with their affiliates and associates, own more than 15% of the subject company from engaging in certain business
combinations for a period of three years following the date that the stockholder became an interested stockholder of such subject company without approval of the board or 662/3% of the independent stockholders. Our board of directors has also adopted a stockholder rights plan, or poison pill, which would significantly dilute the ownership
of a hostile acquirer. Additionally, provisions of our amended and restated certificate of incorporation and bylaws could deter, delay or prevent a third party from acquiring us, even if doing so would benefit our stockholders, including without
limitation, the authority of the board of directors to issue, without stockholder approval, preferred stock with such terms as the board of directors may determine.



|Item 7. | Financial Statements.
|------- | ---------------------

FINANCIAL STATEMENTS

Financial Statements Index



|                                                                                                                                                                 |  |     
|---------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----
|                                                                                                                                                                 |  | Page
|Report of Singer Lewak Greenbaum & Goldstein LLP, Independent Registered Public Accounting Firm of Medivation, Inc.                                              |  | 31  
|                                                                                                                                                                 | 
|Consolidated Balance Sheet as of December 31, 2006                                                                                                               |  | 32  
|                                                                                                                                                                 | 
|Consolidated Statements of Operations for the years ended December 31, 2006 and 2005, and for the period from inception (September 4, 2003) to December 31, 2006 |  | 33  
|                                                                                                                                                                 | 
|Consolidated Statements of Cash Flows for the years ended December 31, 2006 and 2005, and for the period from inception (September 4, 2003) to December 31, 2006 |  | 34  
|                                                                                                                                                                 | 
|Consolidated Statements of Stockholders Equity for the period from inception (September 4, 2003) to December 31, 2006                                           |  | 35  
|                                                                                                                                                                 | 
|Notes to Consolidated Financial Statements                                                                                                                       |  | 36  



30



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Report of Independent Registered Public Accounting Firm

To the Board of Directors

Medivation, Inc.

San Francisco, California

We have audited the consolidated balance sheet of Medivation, Inc. and subsidiaries (a development stage company) (collectively, the Company)
as of December 31, 2006, and the related consolidated statements of operations, stockholders equity and cash flows for each of the two years in the period ended December 31, 2006 and for the period from September 4, 2003
(inception) to December 31, 2006. These financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that
we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial
statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provided a reasonable basis for
our opinion.

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the
financial position of Medivation, Inc. and subsidiaries (a development stage company) as of December 31, 2006, and the results of their operations and their cash flows for each of the two years in the period ended December 31, 2006 and for
the period from September 4, 2003 (inception) to December 31, 2006, in conformity with U.S. generally accepted accounting principles.

SINGER
LEWAK GREENBAUM & GOLDSTEIN LLP

Los Angeles, California

February 12, 2007



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MEDIVATION, INC.

(A DEVELOPMENT STAGE COMPANY)

CONSOLIDATED BALANCE SHEET



|                                                                                                               |  |               |             |  
|-------------------------------------------------------------------------------------------------------------- |  | ------------- | ----------- | -
|                                                                                                               |  | Dec. 31, 2006 |            
|ASSETS                                                                                                         |  |               |             |  
|Current assets:                                                                                                |  |               |             |  
|Cash and cash equivalents                                                                                      |  | $             | 4,649,277   |  
|Short-term investments                                                                                         |  |               | 42,534,315  |  
|Prepaid expenses and other current assets                                                                      |  |               | 322,259     |  
|                                                                                                               |  |               |             |  
|Total current assets                                                                                           |  |               | 47,505,851  |  
|Property and equipment (net of accumulated depreciation of $1,972)                                             |  | $             | 6,791       |  
|Intellectual property (net of accumulated amortization of $13,162)                                             |  |               | 62,738      |  
|Other assets                                                                                                   |  |               | 36,902      |  
|                                                                                                               |  |               |             |  
|Total assets                                                                                                   |  | $             | 47,612,282  |  
|                                                                                                               |  |               |             |  
|LIABILITIES AND STOCKHOLDERS EQUITY                                                                           |  |               |             |  
|Current liabilities:                                                                                           |  |               |             |  
|Accounts payable                                                                                               |  | $             | 1,691,847   |  
|Other current liabilities                                                                                      |  |               | 36,767      |  
|Series A redeemable preferred stock                                                                            |  |               | 11,000      |  
|                                                                                                               |  |               |             |  
|Total current liabilities                                                                                      |  |               | 1,739,614   |  
|Stockholders equity:                                                                                          |  |               |             |  
|Preferred stock, $0.01 par value per share; 1,000,000 shares authorized; no shares issued and outstanding      |  |               |            |  
|Common stock, $.01 par value per share; 50,000,000 shares authorized; 27,723,533 shares issued and outstanding |  |               | 277,235     |  
|Additional paid-in capital                                                                                     |  |               | 78,865,233  |  
|Deferred compensation                                                                                          |  |               | (4,813,229  | )
|Deficit accumulated during the development stage                                                               |  |               | (28,456,571 | )
|                                                                                                               |  |               |             |  
|Total stockholders equity                                                                                     |  |               | 45,872,668  |  
|                                                                                                               |  |               |             |  
|Total liabilities and stockholders equity                                                                     |  | $             | 47,612,282  |  
|                                                                                                               |  |               |             |  

SEE ACCOMPANYING NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



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MEDIVATION, INC.

(A DEVELOPMENT STAGE COMPANY)

CONSOLIDATED STATEMENTS OF OPERATIONS



|                                            |  |                     |            |   |                                         |   |            |   |  |   |            |  
|------------------------------------------- |  | ------------------- | ---------- | - | --------------------------------------- | - | ---------- | - |  | - | ---------- | -
|                                            |  | Year ended Dec. 31, |            |   | Inception(Sep. 4, 2003) toDec. 31, 2006 |  
|                                            |  | 2006                |            |   | 2005                                    |   |           
|Operating expenses:                         |  |                     |            |   |                                         |   |            |   |  |   |            |  
|General and administrative:                 |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Payroll *                                   |  | $                   | 937,677    |   |                                         | $ | 511,032    |   |  | $ | 1,827,293  |  
|Consulting and other professional fees *    |  |                     | 1,964,819  |   |                                         |   | 1,312,009  |   |  |   | 3,866,133  |  
|Other general and administrative            |  |                     | 911,638    |   |                                         |   | 749,994    |   |  |   | 2,028,802  |  
|                                            |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Total general and administrative            |  | $                   | 3,814,134  |   |                                         | $ | 2,573,035  |   |  | $ | 7,722,228  |  
|Research and development:                   |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Payroll *                                   |  | $                   | 1,358,735  |   |                                         | $ | 714,014    |   |  | $ | 2,372,568  |  
|Consulting and other professional fees *    |  |                     | 2,306,660  |   |                                         |   | 1,535,956  |   |  |   | 4,447,521  |  
|Preclinical and clinical studies            |  |                     | 8,405,044  |   |                                         |   | 3,338,742  |   |  |   | 12,570,315 |  
|Other research and development              |  |                     | 261,520    |   |                                         |   | 252,775    |   |  |   | 625,771    |  
|                                            |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Total research and development              |  | $                   | 12,331,959 |   |                                         | $ | 5,841,487  |   |  | $ | 20,016,175 |  
|Total operating expenses                    |  | $                   | 16,146,093 |   |                                         | $ | 8,414,522  |   |  | $ | 27,738,403 |  
|Loss from operations                        |  | $                   | 16,146,093 |   |                                         | $ | 8,414,522  |   |  | $ | 27,738,403 |  
|Other expenses (income):                    |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Interest expense (income)                   |  | $                   | (785,016   | ) |                                         | $ | (209,785   | ) |  | $ | (916,098   | )
|Warrants issued to related party guarantors |  |                     |           |   |                                         |   |           |   |  |   | 17,505     |  
|Liquidated damages expense:                 |  |                     |            |   |                                         |   |            |   |  |   |            |  
|To related parties                          |  |                     |           |   |                                         |   | 1,102,530  |   |  |   | 1,102,530  |  
|To other parties                            |  |                     |           |   |                                         |   | 507,900    |   |  |   | 507,900    |  
|                                            |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Total other expenses (income)               |  | $                   | (785,016   | ) |                                         | $ | 1,400,645  |   |  | $ | 711,837    |  
|Loss before provision for income taxes      |  | $                   | 15,361,077 |   |                                         | $ | 9,815,167  |   |  | $ | 28,450,240 |  
|Provision for income taxes                  |  |                     | 2,331      |   |                                         |   | 2,400      |   |  |   | 6,331      |  
|                                            |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Net loss                                    |  | $                   | 15,363,408 |   |                                         | $ | 9,817,567  |   |  | $ | 28,456,571 |  
|                                            |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Basic and diluted loss per share:           |  | $                   | 0.63       |   |                                         | $ | 0.70       |   |  | $ | 2.46       |  
|                                            |  |                     |            |   |                                         |   |            |   |  |   |            |  
|Weighted average common shares outstanding  |  |                     | 24,247,522 |   |                                         |   | 13,936,629 |   |  |   | 11,582,659 |  
|                                            |  |                     |            |   |                                         |   |            |   |  |   |            |  

---

|* | Includes non-cash stock-based compensation expense. See Note 7(f).
|- | ------------------------------------------------------------------

SEE ACCOMPANYING NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



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MEDIVATION, INC.

(A DEVELOPMENT STAGE COMPANY)

CONSOLIDATED STATEMENTS OF CASH FLOWS



|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|------------------------------------------------------------------------------- |  | ------------------- | ----------- | - | ---------------------------------------- | - | ----------- | - |  | - | ----------- | -
|                                                                                |  | Year ended Dec. 31, |             |   | Inception(Sep. 4, 2003)
to Dec. 31, 2006 |  
|                                                                                |  | 2006                |             |   | 2005                                     |   |            
|Cash flows from operating activities:                                           |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Net loss                                                                        |  | $                   | (15,363,408 | ) |                                          | $ | (9,817,567  | ) |  | $ | (28,456,571 | )
|Adjustments to reconcile net loss to net cash used by operating activities:     |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Impairment of intellectual property                                             |  |                     | 68,238      |   |                                          |   |            |   |  |   | 143,238     |  
|Depreciation and amortization                                                   |  |                     | 7,130       |   |                                          |   | 8,494       |   |  |   | 21,896      |  
|Stock-based compensation                                                        |  |                     | 2,448,853   |   |                                          |   | 1,113,235   |   |  |   | 3,671,354   |  
|Liquidated damages accrued:                                                     |  |                     |             |   |                                          |   |             |   |  |   |             |  
|To related parties                                                              |  |                     |            |   |                                          |   | 1,102,530   |   |  |   | 1,102,530   |  
|To other parties                                                                |  |                     |            |   |                                          |   | 507,900     |   |  |   | 507,900     |  
|Liquidated damages paid:                                                        |  |                     |             |   |                                          |   |             |   |  |   |             |  
|To related parties                                                              |  |                     | (16,120     | ) |                                          |   | (1,086,410  | ) |  |   | (1,102,530  | )
|To other parties                                                                |  |                     | (256,379    | ) |                                          |   | (251,521    | ) |  |   | (507,900    | )
|Warrants issued to related party guarantors                                     |  |                     |            |   |                                          |   |            |   |  |   | 17,505      |  
|Changes in operating assets and liabilities:                                    |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Prepaid expenses and other current assets                                       |  |                     | (28,764     | ) |                                          |   | 11,563      |   |  |   | (317,409    | )
|Other current assets                                                            |  |                     | (36,902     | ) |                                          |   |            |   |  |   | (36,902     | )
|Accounts payable                                                                |  |                     | 516,550     |   |                                          |   | 801,503     |   |  |   | 1,693,488   |  
|Other current liabilities                                                       |  |                     | 29,142      |   |                                          |   | 5,566       |   |  |   | 38,693      |  
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Net cash provided by (used in) operating activities                             |  |                     | (12,631,660 | ) |                                          |   | (7,604,707  | ) |  |   | (23,224,708 | )
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Cash flows from investing activities:                                           |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Medivation cash balances at closing of December 2004 merger                     |  |                     |            |   |                                          |   |            |   |  |   | 1,928,839   |  
|Purchase of short-term investments                                              |  |                     | (56,858,605 | ) |                                          |   | (20,124,804 | ) |  |   | (76,983,409 | )
|Maturities of short-term investments                                            |  |                     | 22,775,623  |   |                                          |   | 12,000,000  |   |  |   | 34,775,623  |  
|Accrued interest on short-term investments                                      |  |                     | (192,409    | ) |                                          |   | (134,120    | ) |  |   | (326,529    | )
|Purchase of property and equipment                                              |  |                     |            |   |                                          |   | (8,763      | ) |  |   | (8,763      | )
|Purchase of intellectual property                                               |  |                     |            |   |                                          |   |            |   |  |   | (225,000    | )
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Net cash provided by (used in) investing activities                             |  |                     | (34,275,391 | ) |                                          |   | (8,267,687  | ) |  |   | (40,839,239 | )
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Cash flows from financing activities:                                           |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Issuance of Series B preferred stock                                            |  |                     |            |   |                                          |   |            |   |  |   | 1,800       |  
|Issuance of convertible notes:                                                  |  |                     |             |   |                                          |   |             |   |  |   |             |  
|To related party                                                                |  |                     |            |   |                                          |   |            |   |  |   | 1,250,000   |  
|To other party                                                                  |  |                     |            |   |                                          |   |            |   |  |   | 600,000     |  
|Principal repayment on notes held by related party                              |  |                     |            |   |                                          |   |            |   |  |   | (595,861    | )
|Issuance of common stock in the December 2004 financing                         |  |                     |            |   |                                          |   |            |   |  |   | 10,700,270  |  
|Issuance of common stock in the December 2005 financing                         |  |                     |             |   |                                          |   | 10,452,925  |   |  |   | 10,452,925  |  
|Issuance of common stock in the May and December 2006 financing                 |  |                     | 50,249,990  |   |                                          |   |            |   |  |   | 50,249,990  |  
|Offering costs payable in cash                                                  |  |                     | (3,498,533  | ) |                                          |   | (689,227    | ) |  |   | (4,187,760  | )
|Class B warrant exercises                                                       |  |                     |            |   |                                          |   | 20,563      |   |  |   | 20,563      |  
|Stock option exercises                                                          |  |                     | 220,937     |   |                                          |   | 360         |   |  |   | 221,297     |  
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Net cash provided by (used in) financing activities                             |  |                     | 46,972,394  |   |                                          |   | 9,784,621   |   |  |   | 68,713,224  |  
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Net increase (decrease) in cash                                                 |  |                     | 65,343      |   |                                          |   | (6,087,773  | ) |  |   | 4,649,277   |  
|Cash at beginning of period                                                     |  |                     | 4,583,934   |   |                                          |   | 10,671,707  |   |  |   |            |  
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Cash at end of period                                                           |  | $                   | 4,649,277   |   |                                          | $ | 4,583,934   |   |  | $ | 4,649,277   |  
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Cash paid for interest to related party                                         |  | $                   |            |   |                                          | $ |            |   |  | $ | 26,859      |  
|Supplemental schedule of non-cash investing and financing activities:*          |  |                     |             |   |                                          |   |             |   |  |   |             |  
|Shares issued for conversion of convertible notes (including accrued interest): |  |                     |             |   |                                          |   |             |   |  |   |             |  
|To related party                                                                |  | $                   |            |   |                                          | $ | 688,955     |   |  | $ | 688,955     |  
|To other party                                                                  |  |                     |            |   |                                          |   | 610,776     |   |  |   | 610,776     |  
|Shares issued to purchase intellectual property                                 |  |                     |            |   |                                          |   |            |   |  |   | 900         |  
|Shares issued for placement agent services in the December 2004 financing       |  |                     |            |   |                                          |   | 969,834     |   |  |   | 969,834     |  
|Warrants issued for placement agent services in the December 2004 financing     |  |                     |            |   |                                          |   | 633,149     |   |  |   | 633,149     |  
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  
|                                                                                |  | $                   |            |   |                                          | $ | 2,902,714   |   |  | $ | 2,903,614   |  
|                                                                                |  |                     |             |   |                                          |   |             |   |  |   |             |  

---

|* | During the year ended December 31, 2006, warrants for 485,677 shares of common stock were exercised on a cashless basis in exchange for 364,839 shares of common stock.
|- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------

SEE ACCOMPANYING NOTES TO CONSOLIDATED FINANCIAL STATEMENTS.



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MEDIVATION, INC.

(A DEVELOPMENT STAGE COMPANY)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS EQUITY

INCEPTION (SEP. 4, 2003)
TO DEC. 31, 2006



|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|------------------------------------------------------- |  | ------------ |  | ------------------------ | ------- |  | -------------------- | ---------- | - | -------------------- | - | ---------- | ------------------------- |  | - | ----------- | - |  | - | ----------- | -
|                                                        |  | COMMON STOCK |  | ADDITIONALPAID-INCAPITAL |         |  | DEFERREDCOMPENSATION |            |   | ACCUMULATED(DEFICIT) |   |            | TOTAL STOCKHOLDERSEQUITY | 
|                                                        |  | SHARES       |  | AMOUNT                   |         |  |                      |           
|Balances at inception (September 4, 2003)               |  |             |  | $                        |        |  | $                    |           |   |                      | $ |           |                           |  | $ |            |   |  | $ |            |  
|Net loss                                                |  |             |  |                          |        |  |                      |           |   |                      |   |           |                           |  |   | (401,449    | ) |  |   | (401,449    | )
|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Balances at December 31, 2003                           |  |             |  |                          |        |  |                      |           |   |                      |   |           |                           |  |   | (401,449    | ) |  |   | (401,449    | )
|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Common stock issued for:                                |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Cash in the December 2004 financing                     |  | 6,903,399    |  |                          | 69,034  |  |                      | 10,631,236 |   |                      |   |           |                           |  |   |            |   |  |   | 10,700,270  |  
|Debt conversion in the December 2004 financing:         |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|To related party                                        |  | 444,487      |  |                          | 4,445   |  |                      | 684,509    |   |                      |   |           |                           |  |   |            |   |  |   | 688,954     |  
|To other party                                          |  | 394,049      |  |                          | 3,940   |  |                      | 606,836    |   |                      |   |           |                           |  |   |            |   |  |   | 610,776     |  
|Placement agent services in the December 2004 financing |  | 625,699      |  |                          | 6,257   |  |                      | 963,577    |   |                      |   |           |                           |  |   |            |   |  |   | 969,834     |  
|Offering expenses                                       |  |             |  |                          |        |  |                      | (1,602,981 | ) |                      |   |           |                           |  |   |            |   |  |   | (1,602,981  | )
|Warrants issued to related party guarantors             |  |             |  |                          |        |  |                      | 17,505     |   |                      |   |           |                           |  |   |            |   |  |   | 17,505      |  
|Stock-based compensation expense                        |  |             |  |                          |        |  |                      | 109,265    |   |                      |   |           |                           |  |   |            |   |  |   | 109,265     |  
|December 2004 merger:                                   |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |            |  
|Elimination of retained earnings                        |  |             |  |                          |        |  |                      | (422,120   | ) |                      |   |           |                           |  |   |            |   |  |   | (422,120    | )
|Common stock outstanding before December 2004 merger    |  | 1,213,507    |  |                          | 12,135  |  |                      | 2,282,231  |   |                      |   |           |                           |  |   |            |   |  |   | 2,294,366   |  
|Net loss                                                |  |             |  |                          |        |  |                      |           |   |                      |   |           |                           |  |   | (2,874,147  | ) |  |   | (2,874,147  | )
|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Balances at December 31, 2004                           |  | 9,581,141    |  | $                        | 95,811  |  | $                    | 13,270,058 |   |                      | $ |           |                           |  | $ | (3,275,596  | ) |  |   | 10,090,273  |  
|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Common stock issued for:                                |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Conversion of Series B preferred stock                  |  | 6,638,490    |  |                          | 66,385  |  |                      | (63,685    | ) |                      |   |           |                           |  |   |            |   |  |   | 2,700       |  
|Cash in the December 2005 financing                     |  | 5,635,000    |  |                          | 56,350  |  |                      | 10,396,575 |   |                      |   |           |                           |  |   |            |   |  |   | 10,452,925  |  
|Cash upon exercise of Class B warrants                  |  | 203,300      |  |                          | 2,033   |  |                      | 23,379     |   |                      |   |           |                           |  |   |            |   |  |   | 25,412      |  
|Cash upon exercise of stock options                     |  | 17,980       |  |                          | 180     |  |                      | 180        |   |                      |   |           |                           |  |   |            |   |  |   | 360         |  
|Offering expenses                                       |  |             |  |                          |        |  |                      | (689,227   | ) |                      |   |           |                           |  |   |            |   |  |   | (689,227    | )
|Stock-based deferred compensation                       |  |             |  |                          |        |  |                      | 2,104,932  |   |                      |   | (2,104,932 | )                         |  |   |            |   |  |   |            |  
|Stock-based compensation expense                        |  |             |  |                          |        |  |                      | 765,669    |   |                      |   | 347,566    |                           |  |   |            |   |  |   | 1,113,235   |  
|Reclassification of warrant liability to equity         |  |             |  |                          |        |  |                      | 633,149    |   |                      |   |           |                           |  |   |            |   |  |   | 633,149     |  
|Adjustments related to December 2004 merger             |  |             |  |                          |        |  |                      | 3,569      |   |                      |   |           |                           |  |   |             |   |  |   | 3,569       |  
|Net loss                                                |  |             |  |                          |        |  |                      |           |   |                      |   |           |                           |  |   | (9,817,567  | ) |  |   | (9,817,567  | )
|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Balances at December 31, 2005                           |  | 22,075,911   |  | $                        | 220,759 |  | $                    | 26,444,599 |   |                      | $ | (1,757,366 | )                         |  | $ | (13,093,163 | ) |  | $ | 11,814,829  |  
|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Common stock issued for:                                |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Cash in the May 2006 financing                          |  | 3,000,000    |  |                          | 30,000  |  |                      | 14,220,000 |   |                      |   |           |                           |  |   |            |   |  |   | 14,250,000  |  
|Cash in the December 2006 financing                     |  | 2,215,384    |  |                          | 22,154  |  |                      | 35,977,836 |   |                      |   |           |                           |  |   |            |   |  |   | 35,999,990  |  
|Cashless exercise of warrants                           |  | 364,839      |  |                          | 3,648   |  |                      | (3,648     | ) |                      |   |           |                           |  |   |            |   |  |   |            |  
|Cash upon exercise of stock options                     |  | 67,399       |  |                          | 674     |  |                      | 220,263    |   |                      |   |           |                           |  |   |            |   |  |   | 220,937     |  
|Offering expenses                                       |  |             |  |                          |        |  |                      | (3,498,533 | ) |                      |   |           |                           |  |   |            |   |  |   | (3,498,533  | )
|Stock-based deferred compensation                       |  |             |  |                          |        |  |                      | 3,902,392  |   |                      |   | (3,902,392 | )                         |  |   |            |   |  |   |            |  
|Stock-based compensation expense                        |  |             |  |                          |        |  |                      | 1,602,324  |   |                      |   | 846,529    |                           |  |   |            |   |  |   | 2,448,853   |  
|Net loss                                                |  |             |  |                          |        |  |                      |           |   |                      |   |           |                           |  | $ | (15,363,408 | ) |  |   | (15,363,408 | )
|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  
|Balances at December 31, 2006                           |  | 27,723,533   |  | $                        | 277,235 |  | $                    | 78,865,233 |   |                      | $ | (4,813,229 | )                         |  | $ | (28,456,571 | ) |  | $ | 45,872,668  |  
|                                                        |  |              |  |                          |         |  |                      |            |   |                      |   |            |                           |  |   |             |   |  |   |             |  

SEE ACCOMPANYING NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



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MEDIVATION, INC.

(A DEVELOPMENT STAGE COMPANY)

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

December 31, 2006

1. DESCRIPTION OF BUSINESS

Medivation, Inc. (Medivation or the Company), together with its operating subsidiaries, is a biopharmaceutical company engaged in the acquisition, research and development of promising medical technologies. The Company focuses particularly
on technologies that have strong intellectual property positions, address large unmet medical needs, and have the potential to enter clinical development within 12 to 18 months after acquisition, and on driving development in a rapid, cost-effective
manner. Medivations current portfolio consists of small molecule drugs in development to treat three large, unmet medical needs  Alzheimers disease, Huntingtons disease and hormone-refractory prostate cancer. The Company
intends to build and maintain a portfolio of four to six development programs at all times.

2. THE MERGER

On December 17, 2004, the Company acquired its operating subsidiary Medivation Neurology, Inc. (MNI) by merger (the Merger). Because the Merger was
accounted for as a reverse merger under generally accepted accounting principles, the consolidated financial statements of the Company for periods prior to December 17, 2004 reflect only the operations of MNI.

3. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

(a) Basis of
Consolidation

The consolidated financial statements incorporate the accounts of Medivation and its operating subsidiaries. All
significant inter-company transactions have been eliminated in consolidation.

(b) Development Stage Company

For the period from inception (September 4, 2003) to date, the Company has been a development stage enterprise, and accordingly, the Companys
operations have been directed primarily toward developing its proprietary technologies. The Company has experienced net losses since its inception and had an accumulated deficit of $28,456,571 at December 31, 2006. Such losses and accumulated
deficit resulted from the Companys absence of revenue and significant costs incurred in the development of the Companys proprietary technologies. The Company expects to incur substantial and increasing losses as it continues to expand
its research and development activities and increases headcount to staff these activities.

(c) Estimates

The preparation of financial statements in conformity with generally accepted accounting principles requires that management make estimates and
assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period.
Estimates and assumptions principally relate to services performed by third parties but not yet invoiced, estimates of the fair value of stock options issued to employees and consultants and estimates of the probability and potential magnitude of
contingent liabilities. Actual results could differ from those estimates.

(d) Cash Equivalents

The Company considers all highly liquid investments purchased with an original maturity of three months or less to be cash equivalents. At
December 31, 2006, cash and cash equivalents consisted of $4,649,277 in cash and money market securities. The Company deposits cash and cash equivalents with high credit quality financial



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institutions and is insured to the maximum limitations. The Company and its operating subsidiaries presently maintain checking and money market accounts at
Bank of America and Wells Fargo. Cash and cash equivalents held in these accounts totaled $923,204 at December 31, 2006, and are insured by the Federal Deposit Insurance Corporation up to a maximum of $100,000. The Company also maintains a
brokerage account at Bank of America, with a cash and cash-equivalent balance of $3,726,073 at December 31, 2006. Deposits in this account are insured by the Securities Investor Protection Corporation up to a maximum of $500,000 (including cash
claims limited to $100,000).

(e) Short-Term Investments Held to Maturity

The Company considers all highly liquid investments purchased with an original maturity of more than three months but no longer than twelve months to be
short-term investments. See Note 4.

(f) Property and Equipment

Property and equipment purchases are recorded at cost. Repairs and maintenance costs are expensed in the period incurred. Items of property and equipment with costs greater than $5,000 are capitalized and depreciated
on a straight-line basis over the estimated useful lives of the assets as follows:



|                                    |  |                                                 
|----------------------------------- |  | ------------------------------------------------
|Description                         |  | Estimated Useful Life                           
|Office equipment and furniture      |  | 3 years                                         
|Laboratory equipment                |  | 5 years                                         
|Leasehold improvements and fixtures |  | Lesser of estimated useful life or life of lease

(g) Intellectual Property

The cost of acquiring intellectual property rights to be used in the research and development process, including licensing fees and milestone payments, is charged to research and development expense as incurred in
situations where we have not identified an alternative future use for the acquired rights, and is capitalized in situations where we have identified an alternative future use. Capitalized costs are amortized over the life of the applicable
intellectual property right. Legal and other costs of prosecuting and maintaining intellectual property rights are expensed as incurred.

(h) Impairment
or Disposal of Long-lived Assets

The Company evaluates its long-lived assets, primarily its intellectual property, for impairment
whenever events or changes in circumstances indicate that the carrying amount of such assets or intangibles may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future
undiscounted net cash flows expected to be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured by the amount by which the carrying amount of the assets exceeds the fair value of the
assets. Assets to be disposed of are reported at the lower of the carrying amount or fair value less cost to sell. The impairment amount is included in research and development expenses.

(i) Research and Development

Research and development costs are charged to expense when incurred.

(j) Stock Based Compensation; Adoption of SFAS 123R

Effective January 1, 2005, the Company adopted SFAS 123R, Share-Based Payment, which requires the Company to record as an expense in its financial statements the fair value of all stock-based
compensation awards.



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(k) Income Taxes

The Company accounts for income taxes in accordance with SFAS No. 109, Accounting for Income Taxes, which requires the recognition of deferred tax assets and liabilities for the expected future tax
consequences of events that have been included in the financial statements or tax returns. Under this method, deferred income taxes are recognized for the tax consequences in future years of differences between the tax bases of assets and
liabilities and their financial reporting amounts at each year-end based on enacted tax laws and statutory tax rates applicable to the periods in which the differences are expected to affect taxable income. Valuation allowances are established, when
necessary, to reduce deferred tax assets to the amount expected to be realized. The provision for income taxes represents the tax payable for the period and the change during the period in deferred tax assets and liabilities.

(l) Loss per Common Share

The Company calculates
loss per share in accordance with SFAS No. 128, Earnings per Share. Basic loss per share is computed by dividing the loss available to common shareholders by the weighted-average number of common shares outstanding. Diluted loss per
share is computed similarly to basic loss per share except that the denominator is increased to include the number of additional common shares that would have been outstanding if the potential common shares had been issued and if the additional
common shares were dilutive.

The following potential common shares represented by warrants and options have been excluded from the
computation of diluted net loss per share, as they have an antidilutive effect due to the Companys net loss:



|         |  |                     |  |                                         |  |          
|-------- |  | ------------------- |  | --------------------------------------- |  | ---------
|         |  | Year ended Dec. 31, |  | Inception(Sep. 4, 2003) toDec. 31, 2006
|         |  | 2006                |  | 2005                                    | 
|Warrants |  | 338,814             |  | 824,491                                 |  | 338,814  
|Options  |  | 2,211,750           |  | 1,550,200                               |  | 2,211,750
|         |  |                     |  |                                         |  |          
|Total    |  | 2,550,564           |  | 2,374,691                               |  | 2,550,564
|         |  |                     |  |                                         |  |          

(m) Recently Issued Accounting Pronouncements

In February 2006, the FASB issued SFAS No. 155, Accounting for Certain Hybrid Financial Instruments (SFAS 155), which amends SFAS
No. 133, Accounting for Derivatives Instruments and Hedging Activities (SFAS 133) and SFAS No. 140, Accounting for Transfers and Servicing of Financial Assets and Extinguishment of Liabilities (SFAS 140). SFAS 155
amends SFAS 133 to narrow the scope exception for interest-only and principal-only strips on debt instruments to include only such strips representing rights to receive a specified portion of the contractual interest or principle cash flows. SFAS
155 also amends SFAS 140 to allow qualifying special-purpose entities to hold a passive derivative financial instrument pertaining to beneficial interests that itself is a derivative instrument. Management does not expect the adoption of
SFAS 155 to have a material impact on the Companys financial statements.

In July 2006, the FASB issued FASB Interpretation
No. 48, Accounting for Uncertainty in Income Taxesan interpretation of FASB Statement No. 109 (FIN 48), which clarifies the accounting for uncertainty in tax positions. This interpretation requires that the Company
determine whether it is more likely than not that a tax position will be sustained upon examination based on the technical merits of the position, and measure the amount of benefit to be recognized in the financial statements for a tax position that
meets the more- likely-than-not recognition threshold. FIN 48 is effective for fiscal years beginning after December 15, 2006. Management does not expect the adoption of FIN 48 to have a material impact on the Companys financial
statements.

In September 2006, the U.S. Securities and Exchange Commission (the SEC) issued Staff Accounting Bulletin
(SAB) No. 108, which expresses the views of the SEC staff regarding the process of quantifying



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financial statement misstatements. SAB No. 108 provides guidance on the consideration of the effects of prior year misstatements in quantifying current
year misstatements for the purpose of a materiality assessment. The guidance of this SAB is effective for annual financial statements covering the first fiscal year ending after November 15, 2006, which is December 31, 2006 for the
Company. SAB No. 108 did not have an impact on the Companys consolidated financial statements.

In September 2006, the FASB
issued Statement of Financial Accounting Standards No. 157, Defining Fair Value Measurement (FAS 157), which defines fair value, establishes a framework for measuring fair value in generally accepted accounting principles and
expands disclosures about fair value measurements. FAS 157 is effective for financial statements issued for fiscal years beginning after November 15, 2007. The Company is currently evaluating the impact of adopting FAS 157 on its financial
statements.

4. SHORT-TERM INVESTMENTS HELD TO MATURITY

The Company accounts for its short-term investments in accordance with SFAS No. 115, Accounting for Certain Investments in Debt and Equity Securities. At December 31, 2006, short-term investments
consisted of Federal Home Loan Bank securities purchased in August, September and December 2006 with maturities in February, March and May 2007. The Company has accounted for these investments as held-to-maturity since it has the positive
intent and ability to hold them to maturity, and thus has recorded them at their amortized cost basis of $42,534,315 in its financial statements at December 31, 2006. At December 31, 2006, the estimated fair value of these securities was
$42,502,043, resulting in a gross unrealized holding loss of $32,272.

5. PROPERTY AND EQUIPMENT

At December 31, 2006, property and equipment consisted of laboratory equipment purchased in November 2005 for $8,763, which is being depreciated
on a straight-line basis over its estimated useful life of five years. Depreciation expense in the years ended December 31, 2006 and 2005, and in the period from inception (September 4, 2003) to December 31, 2006, was $1,753, $219 and
$1,972, respectively.

6. INTELLECTUAL PROPERTY

At December 31, 2006, intellectual property consisted of patents and patent applications acquired from third parties. Cash purchases of patent rights totaled $0, $0 and $225,000, respectively, for the years ended December 31, 2006
and 2005, and for the period from inception (September 4, 2003) to December 31, 2006. This intellectual property is being amortized over periods ranging from 156 months to 248 months. Amortization expense on the Companys intellectual
property was $5,377, $8,275 and $19,924, respectively, for the years ended December 31, 2006 and 2005, and for the period from inception (September 4, 2003) to December 31, 2006. Estimated aggregate amortization expense on the
Companys intellectual property is $4,412 per year for each of the five subsequent fiscal years. In the years ended December 31, 2006 and 2004, the Company wrote off $68,238 and $75,000, respectively, of its historical patent acquisition
costs to reflect managements decision to stop work on a patent application that is unrelated to the Companys ongoing development programs.

7. STOCKHOLDERS EQUITY

(a) Common Stock

In May and December 2006, the Company issued 5,215,384 shares of its Common Stock in registered direct offerings, raising gross proceeds of $50,249,990. Placement agent, legal, accounting, printing and other costs
related to these offerings, in the aggregate amount of $3,498,533, were charged to additional paid-in capital in the year ended December 31, 2006.



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In December 2005, the Company issued 5,635,000 shares of its Common Stock in an underwritten public
offering, raising net proceeds of $10,452,925. Legal, accounting, printing, travel and other costs related to this offering, in the aggregate amount of $689,227, were charged to additional paid-in capital in the year ended December 31, 2005.

On December 17, 2004, the Company issued 7,741,935 shares of its Common Stock in a private placement, 6,903,399 of which were sold
for cash, generating $10,700,270 in gross proceeds. The remaining 838,536 shares were issued in exchange for cancellation of outstanding bridge notes of MNI, in the aggregate amount of $1,299,731. Medivation also issued an aggregate of 625,699
shares of its Common Stock to two investment banking firms as partial compensation for placement agent services provided in connection with this offering. The cost of these shares, in the aggregate amount of $969,834, was offset against additional
paid-in-capital in the year ended December 31, 2004.

(b) Stock Purchase Rights

Common shares outstanding are subject to stock purchase rights. The rights are exercisable only if a person or group acquires twenty percent or more of
the Companys Common Stock or announces a tender or exchange offer which would result in ownership of twenty percent or more of the Companys Common Stock. Following the acquisition of twenty percent or more of the Companys Common
Stock, the holders of the rights, other than the acquiring person or group, may purchase Medivation Common Stock at half price. In the event of a merger or other acquisition of the Company, the holders of the rights, other than the acquiring person
or group, may purchase shares of the acquiring entity at half price. The rights were not exercisable at December 31, 2006.

(c) Preferred Stock

The Company is authorized to issue 1,000,000 shares of preferred stock with such designations, voting, and other rights and preferences
as may be determined from time to time by the Board of Directors. The Company has outstanding 110 shares of Series A Redeemable Preferred Stock, which it issued for an aggregate purchase price of $11,000. The Series A Redeemable Preferred Stock is
non-voting and does not bear dividends. The right of the holders of the Series A Redeemable Preferred Stock to convert their shares into Common Stock expired unexercised in December 2005. The Series A Redeemable Preferred Stock is redeemable at
any time, at the option of the holders thereof, for a redemption price equal to its original purchase price. Because of this redemption feature, the Series A Redeemable Preferred Stock is reflected as a liability on the consolidated financial
statements. No other preferred stock of the Company is outstanding.

(d) Warrants Issued to Related Parties

On November 16, 2004, MNI issued warrants to purchase its equity securities to two of its officers in return for their agreement to guarantee certain
corporate obligations. The fair value of these warrants in the amount of $17,505 (based on the Black-Scholes option pricing model and the following assumptions: stock price of $1.55; historical volatility of 90%; risk free rate of approximately
4.5%; dividend yield of 0%; and warrant life of 10 years) was recorded as an expense in the year ended December 31, 2004.

(e) Other Warrants

On December 17, 2004, Medivation issued warrants to an investment banking firm in return for placement agent services provided in
connection with the 2004 offering. The fair value of these warrants, in the amount of $633,149 (based on the Black-Scholes option pricing model and the following assumptions: stock price of $1.55; historical volatility of 90%; risk free rate of
3.59%; dividend yield of 0%; and warrant life of 5.0 years), was charged to additional paid-in capital in the year ended December 31, 2004.

(f)
Medivation Equity Incentive Plan

The Medivation 2004 Equity Incentive Plan (the Medivation Equity Incentive Plan), which is
stockholder-approved, provides for the issuance of options and other equity-based awards, including restricted stock and



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stock appreciation rights, covering up to 3,000,000 shares of Medivations common stock. Shares issued upon exercise of equity-based awards are new
shares that have been reserved for issuance under the plan. The Medivation Equity Incentive Plan is administered by our board of directors, or a committee appointed by the Board, which determines recipients and types of awards to be granted,
including the number of shares subject to the awards, the exercise price and the vesting schedule. The term of stock options granted under the Medivation Equity Incentive Plan cannot exceed ten years. Options generally have an exercise price equal
to the fair market value of our common stock on the grant date, and generally vest over a period of four years. The options may contain an early exercise feature, pursuant to which the optionee may exercise the option before it has vested. However,
so long as an option remains unvested, all shares purchased upon early exercise remain subject to repurchase by Medivation at the option exercise price if the optionees service with Medivation terminates. For purposes of the following
disclosures, early exercise options are not considered to have been exercised, or to be exercisable, until this repurchase right has lapsed. In addition, all outstanding awards under the Medivation Equity Incentive Plan will accelerate and become
immediately exercisable upon a change of control of Medivation, as defined in the Medivation Equity Incentive Plan.

The
stock-based compensation expense recorded by the Company for the years ended December 31, 2006 and 2005 and the period from inception (September 4, 2003) to December 31, 2006 with respect to awards under the Medivation Equity Incentive
Plan is as follows:



|                                       |  |                     |           |                                         |   |           |  |   |          
|-------------------------------------- |  | ------------------- | --------- | --------------------------------------- | - | --------- |  | - | ---------
|                                       |  | Year ended Dec. 31, |           | Inception(Sep. 4, 2003) toDec. 31, 2006
|                                       |  | 2006                |           | 2005                                    |  
|Income statement line item:            |  |                     |           |                                         |   |           |  |   |          
|General and administrative:            |  |                     |           |                                         |   |           |  |   |          
|Payroll                                |  | $                   | 265,127   |                                         | $ | 110,784   |  | $ | 375,911  
|Consulting and other professional fees |  |                     | 1,158,442 |                                         |   | 463,248   |  |   | 1,719,121
|Research and development:              |  |                     |           |                                         |   |           |  |   |          
|Payroll                                |  |                     | 441,023   |                                         |   | 236,781   |  |   | 677,805  
|Consulting and other professional fees |  |                     | 584,261   |                                         |   | 302,422   |  |   | 898,520  
|                                       |  |                     |           |                                         |   |           |  |   |          
|Total                                  |  | $                   | 2,448,853 |                                         | $ | 1,113,235 |  | $ | 3,671,357
|                                       |  |                     |           |                                         |   |           |  |   |          

Options granted to employees and non-employee directors are recorded as deferred compensation at
their grant-date fair value, and expensed over the remaining vesting periods of the options. At December 31, 2006, deferred compensation not yet recognized as expense totaled $4,813,229, and will be recognized as expense over a weighted-average
period of 3.2 years. Options granted to consultants are valued at their respective measurement dates, and recognized as expense based on the portion of the total consulting services provided during the applicable period. As further consulting
services are provided in future periods, Medivation will revalue the associated options and recognize additional expense based on their then-current fair values.

Medivation estimates the fair value of each option award using the Black-Scholes option valuation model. Estimated volatility is based on the historical stock price volatility of Medivation and comparable companies.
Estimated dividend yield is 0%. Estimated option term presently is six years for options granted to employees and directors, and four years for options granted to consultants. The risk-free rate is estimated to equal U.S. Treasury security rates for
the applicable terms. The Black-Scholes assumptions used in the years ended December 31, 2006 and 2005 are as follows:



|                                     |  |                          |   |  |                          |  
|------------------------------------ |  | ------------------------ | - |  | ------------------------ | -
|                                     |  | Year Ended Dec. 31, 2006 |   |  | Year Ended Dec. 31, 2005 |  
|Expected volatility                  |  | 5584                    | % |  | 7090                    | %
|Weighted-average expected volatility |  | 69                       | % |  | 80                       | %
|Expected dividends                   |  | 0                        | % |  | 0                        | %
|Expected remaining term (in years)   |  | 1.510.0                 |   |  | 3.510.0                 |  
|Risk-free rate                       |  | 4.55.1                  | % |  | 3.74.5                  | %



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At December 31, 2006, the total outstanding, and the total exercisable, options under the Medivation
Equity Incentive Plan were as follows:



|                          |  |                                  |  |                               |      |                                          |           |                         |   |           
|------------------------- |  | -------------------------------- |  | ----------------------------- | ---- | ---------------------------------------- | --------- | ----------------------- | - | ----------
|                          |  | NumberOutstandingatDec. 31, 2006 |  | Weighted-AverageExercisePrice |      | Weighted-AverageRemainingContractualTerm |           | AggregateIntrinsicValue
|Total outstanding options |  | 2,211,750                        |  | $                             | 4.53 |                                          | 8.7 years |                         | $ | 24,967,946
|Total exercisable options |  | 695,331                          |  | $                             | 2.28 |                                          | 8.1 years |                         | $ | 9,411,660 

A summary of the stock option activity under the Medivation Equity Incentive Plan during the year
ended December 31, 2006 is presented below.



|                                 |  |                          |  |                               |     
|-------------------------------- |  | ------------------------ |  | ----------------------------- | ----
|                                 |  | Year Ended Dec. 31, 2006
|                                 |  | Number ofOptions         |  | Weighted-AverageExercisePrice
|Outstanding at beginning of year |  | 1,550,200                |  | $                             | 2.50
|Granted                          |  | 876,900                  |  | $                             | 7.70
|Exercised                        |  | 67,399                   |  | $                             | 3.28
|Forfeited                        |  | 147,951                  |  | $                             | 2.58
|Outstanding at end of year       |  | 2,211,750                |  | $                             | 4.53

The weighted-average grant-date fair value of options granted during the years ended
December 31, 2006 and 2005, and during the period from inception (September 4, 2003) to December 31, 2006, was $4.85 per share, $2.66 per share and $3.08 per share, respectively. Further information regarding the value of options
vested and exercised during the years ended December 31, 2006 and 2005, and during the period from inception (September 4, 2003) to December 31, 2006, is set forth below.



|                                                   |  |                          |           |                          |   |                                           |  |   |          
|-------------------------------------------------- |  | ------------------------ | --------- | ------------------------ | - | ----------------------------------------- |  | - | ---------
|                                                   |  | Year Ended Dec. 31, 2006 |           | Year Ended Dec. 31, 2005 |   | Inception (Sep. 4, 2003) to Dec.
31, 2006
|Fair value of options vested during period         |  | $                        | 3,674,426 |                          | $ | 520,001                                   |  | $ | 4,194,427
|Intrinsic value of options exercised during period |  | $                        | 654,431   |                          | $ | 53,580                                    |  | $ | 708,011  

8. THIRD PARTY EQUITY INTERESTS IN OPERATING SUBSIDIARIES

(a) Medivation Neurology, Inc.

At December 31,
2006, Medivation owned all of the issued and outstanding stock of its operating subsidiary MNI, and there were no outstanding options, warrants or any other third party rights to acquire any MNI stock.

(b) Medivation Prostate Therapeutics, Inc.

At
December 31, 2006, Medivation owned all 7,918,399 shares of the issued and outstanding stock of its operating subsidiary MPT, and is entitled to receive one additional share for each dollar that Medivation invests, directly or indirectly, in
MPT. MPT has reserved an aggregate of 3,000,000 shares of its Common Stock for issuance upon the exercise of awards granted under the Medivation Prostate Therapeutics, Inc. Equity Incentive Plan (the MPT Equity Incentive Plan). At December 31,
2006, two options were outstanding under the MPT Equity Incentive Plan. These options are exercisable without cash payment for an aggregate of 162,500 shares of MPT Common Stock, but vest and become exercisable only upon the occurrence of specified
MPT liquidity events including a sale of MPT, a public offering of MPTs Common Stock, a corporate partnership involving MPT, or receipt of regulatory approval to market any MPT product. In accordance with Emerging Issues Task



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Force (EITF) Issue No. 96-18, Accounting for Equity Instruments That Are Issued to Other Than Employees for Acquiring, or in Conjunction with
Selling, Goods or Services, no expense will be recognized with respect to these options unless and until such a liquidity event occurs.

9.
LIQUIDATED DAMAGES TO RELATED AND OTHER PARTIES

In December 2005 and January 2006, the Company signed settlement agreements
with investors in its December 2004 private placement, pursuant to which the investors agreed to settle claims arising from a delay in the effectiveness of the registration statement covering their shares and from the Companys inability
to include certain of those shares in the registration statement. In the year ended December 31, 2005, the Company recorded aggregate liquidated damages of $1,610,430 to these investors, including related party investors, as follows:



|                                                         |  |                       |           |                |   |         |  |   |          
|-------------------------------------------------------- |  | --------------------- | --------- | -------------- | - | ------- |  | - | ---------
|Liquidated Damages Attributable to:                      |  | RelatedPartyInvestors |           | OtherInvestors |   | Total  
|The delay in effectiveness of the registration statement |  | $                     | 94,852    |                | $ | 181,148 |  | $ | 276,000  
|The inability to register the excluded shares            |  | $                     | 1,007,678 |                | $ | 326,752 |  | $ | 1,334,430
|                                                         |  |                       |           |                |   |         |  |   |          
|                                                         |  | $                     | 1,102,530 |                | $ | 507,900 |  | $ | 1,610,430

The related party investors consist of an institutional investor that owned more than 10% of the
outstanding voting stock of Medivation at December 31, 2005, and a corporate investor that is wholly-owned by a member of Medivations Board of Directors. The formulas used to calculate the liquidated damages payable to the related party
investors were identical to those used to calculate the liquidated damages payable to all other investors.

The Company paid the accrued
liquidated damages in the years ended December 31, 2006 and 2005, as follows:



|                                         |  |                       |           |                |   |         |  |   |          
|---------------------------------------- |  | --------------------- | --------- | -------------- | - | ------- |  | - | ---------
|Liquidated Damages                       |  | RelatedPartyInvestors |           | OtherInvestors |   | Total  
|Paid in the year ended December 31, 2005 |  | $                     | 1,086,410 |                | $ | 251,521 |  | $ | 1,337,931
|Paid in the year ended December 31, 2006 |  | $                     | 16,120    |                | $ | 256,379 |  | $ | 272,499  
|                                         |  |                       |           |                |   |         |  |   |          
|                                         |  | $                     | 1,102,530 |                | $ | 507,900 |  | $ | 1,610,430

10. INCOME TAXES

The components of net deferred tax assets and liabilities as of December 31, 2006 consisted of the following:



|                                     |  |   |             |  
|------------------------------------ |  | - | ----------- | -
|Deferred tax assets                  |  |   |             |  
|Net operating loss carryforward      |  | $ | 10,091,008  |  
|Stock-based compensation             |  |   | 1,495,849   |  
|Depreciation, amortization and other |  |   | 48,711      |  
|State taxdeferred                   |  |   | (876,895    | )
|Research & development credit        |  |   | (332,380    | )
|Less valuation allowance             |  |   | (11,091,053 | )
|                                     |  |   |             |  
|Net deferred tax assets              |  | $ |            |  
|                                     |  |   |             |  

The valuation allowance increased by $6,452,772 and $3,374,550 during the years ended
December 31, 2006 and December 31, 2005, respectively. The deferred income tax benefit of the loss carryforward is the only significant deferred income tax asset or liability of the Company and has been offset by a valuation allowance



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since management does not believe the recoverability of this deferred tax asset during the next fiscal year is more likely than not. Accordingly, a deferred
income tax benefit for the year ended December, 31, 2006 has not been recognized in these financial statements.

At December 31, 2006,
the Company had net operating loss carryforwards for federal and state income tax purposes of approximately $23,527,000 and $23,664,000, respectively. The net operating loss carryforwards begin expiring in 2021 and 2011, respectively. The usage of
net operating losses generated prior to 2005 of approximately $3,395,000 and $3,537,000 for federal and state tax purposes, respectively, are subject to limitations due to the occurrence of an ownership change as defined under IRC Section 382.

At December 31, 2006, the Company has research and development credit carry forwards of approximately $164,000 and $169,000 for
federal and state income tax purposes, respectively. If not utilized, the federal carry forward will expire in various amounts beginning in 2025. The California credit can be carried forward indefinitely.

Reconciliation of the statutory federal income tax to the Companys effective tax rate follows



|                                              |  |                         |    |  |                         |   
|--------------------------------------------- |  | ----------------------- | -- |  | ----------------------- | --
|                                              |  | Year EndedDec. 31, 2006 |    |  | Year EndedDec. 31, 2005 |   
|Statutory regular federal income benefit rate |  | (34.0                   | )% |  | (34.0                   | )%
|State taxes (net of federal benefit)          |  | (6.4                    | )% |  | (4.6                    | )%
|Nondeductible expenses                        |  |                        |    |  | 5.6                     | % 
|Other                                         |  | (1.6                    | )% |  | (1.4                    | )%
|Change in valuation allowance                 |  | 42.0                    | %  |  | 34.4                    | % 
|                                              |  |                         |    |  |                         |   
|Total                                         |  | 0.0                     | %  |  | 0.0                     | % 
|                                              |  |                         |    |  |                         |   

11. COMMITMENTS AND CONTINGENCIES

The Company leases a single office facility in San Francisco, California under a non-cancelable operating lease that expires in April 2011. Total
rent expense in the years ended December 31, 2006 and 2005, and in the period from inception (September 4, 2003) to December 31, 2006, were $135,791, $59,761 and $263,080, respectively.

At December 31, 2006, the future minimum lease payments are as follows:



|      |  |   |        
|----- |  | - | -------
|2007  |  | $ | 148,654
|2008  |  |   | 154,326
|2009  |  |   | 159,998
|2010  |  |   | 165,670
|2011  |  |   | 55,775 
|      |  |   |        
|Total |  | $ | 684,423
|      |  |   |        



|Item 8. | Changes In and Disagreements With Accountants on Accounting and Financial Disclosure.
|------- | -------------------------------------------------------------------------------------

There has been no change of accountants nor any disagreements with accountants on any matter of accounting principles or practices or financial statement
disclosure required to be reported under this Item.



|Item 8A. | Controls and Procedures.
|-------- | ------------------------

The company maintains
disclosure controls and procedures that are designed to ensure that information required to be disclosed in the companys reports under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the
Commissions rules and forms and that such information is accumulated and communicated to the companys management, including its Chief Executive Officer and Chief



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Financial Officer, as appropriate, to allow for timely decisions regarding required disclosure. In designing and evaluating the disclosure controls and
procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives, and management is required to apply its judgment in
evaluating the cost-benefit relationship of possible controls and procedures.

As required by Commission Rule 13a-15(b), the company
carried out an evaluation, under the supervision and with the participation of the companys management, including the companys Chief Executive Officer and the companys Chief Financial Officer, of the effectiveness of the design and
operation of the companys disclosure controls and procedures as of the end of the quarter covered by this Report. Based on the foregoing, the companys Chief Executive Officer and Chief Financial Officer concluded that the companys
disclosure controls and procedures were effective at the reasonable assurance level.

There has been no change in the companys
internal control over financial reporting during the companys most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the companys internal control over financial reporting.

The Company is not an accelerated filer for the 2006 fiscal year because it remains qualified as a small business issuer. Hence,
under current law, the internal controls certification and attestation requirements of Section 404 of the Sarbanes-Oxley act will not apply to the Company until the fiscal years ended December 31, 2007 and 2008, respectively. Notwithstanding
the fact that these internal control requirements do not apply to the Company at this time, management has begun reviewing the Companys internal control procedures to facilitate compliance with those requirements when they become applicable.



|Item 8B. | Other Information.
|-------- | ------------------

Not applicable.



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PART III



|Item 9. | Directors, Executive Officers, Promoters, Control Persons and Corporate Governance; Compliance With Section 16(a) of the Exchange Act.
|------- | --------------------------------------------------------------------------------------------------------------------------------------

The information to be provided under the captions Management and Election of Directors, each to be contained in the Definitive
Proxy Statement and required to be disclosed in this Item 9, is hereby incorporated by reference in this Item 9; and the information to be provided under the caption Section 16(a) Beneficial Ownership Reporting Compliance, to
be contained in the Definitive Proxy Statement and required to be disclosed pursuant to Section 16(a) of the Exchange Act, is also hereby incorporated by reference in this Item 9.

We have adopted a written code of business conduct and ethics that applies to our principal executive officer, principal financial officer, principal
accounting officer or controller, or persons serving similar functions. The code of business conduct and ethics is attached as an exhibit to this Report and is also available on our corporate website (www.medivation.com).



|Item 10. | Executive Compensation.
|-------- | -----------------------

The information to be
provided under the caption Compensation of Directors and Executive Officers, to be contained in the Definitive Proxy Statement and required to be disclosed in this Item 10, is hereby incorporated by reference in this Item 10.



|Item 11. | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.
|-------- | -----------------------------------------------------------------------------------------------

The information to be provided under the captions Equity Compensation Plan Information and Security Ownership of Certain Beneficial
Owners and Management, each to be contained in the Definitive Proxy Statement and required to be disclosed in this Item 11, is hereby incorporated by reference in this Item 11.



|Item 12. | Certain Relationships and Related Transactions, and Director Independence.
|-------- | --------------------------------------------------------------------------

The information to be provided under the caption Certain Relationships and Related Transactions, and Director Independence, to be contained in the Definitive Proxy Statement and required to be disclosed in
this Item 12, is hereby incorporated by reference in this Item 12.



|Item 13. | Exhibits.
|-------- | ---------

Exhibits

Unless otherwise indicated below, the Commission file number to the exhibit is No. 000-20837.



|            |  |                                                                                                                                                                                                                                                                                                                              
|----------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                                                                                                                          
|2.1         |  | Agreement and Plan of Merger dated as of December 17, 2004, by and among the Orion Acquisition Corp. II, Medivation Acquisition Corp. and Medivation, Inc. (incorporated by reference to Exhibit
2.1 to the Current Report on Form 8-K of Medivation, Inc. (formerly Orion Acquisition Corp. II) filed on December 20, 2004).
|            | 
|3.1(a)      |  | Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1(a) to the Quarterly Report on Form 10-QSB of Medivation, Inc. for the quarter ended June 30,
2005).                                                                                                                              
|            | 
|3.1(b)      |  | Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1(b) to the Quarterly Report on Form 10-QSB of Medivation, Inc. for the
quarter ended June 30, 2005).                                                                                                  



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|            |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
|----------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|3.1(c)      |  | Certificate of Amendment to the Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1(c) to the Quarterly Report on Form 10-QSB of Medivation, Inc. for the
quarter ended June 30, 2005).                                                                                                                                                                                                                                                                            
|            | 
|3.2         |  | Bylaws of Medivation, Inc. (formerly Orion Acquisition Corp. II), together with all amendments and restatements thereto (incorporated by reference to Exhibit 3.2 to the Registration Statement on
Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-03252)).                                                                                                                                                                                                                   
|            | 
|4.1         |  | Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No.
333-03252)).                                                                                                                                                                                                                                                                                                                  
|            | 
|4.2         |  | Rights Agreement, dated as of December 4, 2006, between Medivation, Inc. and American Stock Transfer & Trust Company, as Rights Agent, which includes the form of Certificate of
Designations of the Series C Junior Participating Preferred Stock of Medivation, Inc. as Exhibit A, the form of Right Certificate as Exhibit B and the Summary of Rights to Purchase Preferred Shares as Exhibit C (incorporated by reference to Exhibit
4.1 to the Current Report on Form 8-K filed on December 4, 2006).
|            | 
|10.1(a)     |  | Registration Rights Agreement by and among Orion Acquisition Corp. II and Special Situations Fund III, L.P., Special Situations Cayman Fund, L.P. and Special Situations Private Equity Fund,
L.P., dated as of December 17, 2004 (incorporated by reference to Exhibit 10.3(a) to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                    
|            | 
|10.2(a)     |  | Warrant to purchase Common Stock of Medivation Neurology, Inc. assumed by Orion Acquisition Corp. II issued to Joseph J. Grano, Jr., dated as of June 8, 2004 (incorporated by reference to
Exhibit 10.5(a) to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                        
|            | 
|10.2(b)     |  | Warrant to purchase Common Stock of Medivation Neurology, Inc. assumed by Orion Acquisition Corp. II issued to Joseph J. Grano, Jr., dated as of August 1, 2004 (incorporated by reference to
Exhibit 10.5(b) to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                      
|            | 
|10.2(c)     |  | Warrant to purchase Common Stock of Medivation Neurology, Inc. assumed by Orion Acquisition Corp. II issued to Joseph J. Grano, Jr., dated as of September 1, 2004 (incorporated by reference to
Exhibit 10.5(c) to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                   
|            | 
|10.2(d)     |  | Amendment Agreement by and between Orion Acquisition Corp. II and Joseph J. Grano, Jr., dated as of December 17, 2004 (incorporated by reference to Exhibit 10.5(d) to the Registration
Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                                                                
|            | 
|10.3        |  | Warrant to purchase Common Stock of Medivation Neurology, Inc. assumed by Orion Acquisition Corp. II issued to David T. Hung, M.D., dated as of November 16, 2004 (incorporated by reference
to Exhibit 10.6 to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                       
|            | 
|10.4(a)*    |  | 2004 Equity Incentive Plan of Medivation Neurology, Inc., assumed by Orion Acquisition Corp. II (incorporated by reference to Exhibit 10.7(a) to the Registration Statement on Form SB-2 of
Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                                                                                      
|            | 
|10.4(b)     |  | Form of Stock Option Agreement of Medivation Neurology, Inc., assumed by Orion Acquisition Corp. II (incorporated by reference to Exhibit 10.7(b) to the Annual Report on Form 10-KSB of
Medivation, Inc. (formerly Orion Acquisition Corp. II) for the year ended December 31, 2004).                                                                                                                                                                                                                     



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|            |  |                                                                                                                                                                                                                                                                             
|----------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                                                                         
|10.4(c)     |  | Form of Stock Option Agreement of Medivation, Inc., assumed by Orion Acquisition Corp. II (incorporated by reference to Exhibit 10.7(c) to the Annual Report on Form 10-KSB of Medivation, Inc.
(formerly Orion Acquisition Corp. II) for the year ended December 31, 2004).
|10.5        |  | Agreement by and between QS Pharma, LLC and Medivation, Inc., dated as of January 11, 2005 (incorporated by reference to Exhibit 10.9(b) to the Registration Statement on Form SB-2 of Medivation,
Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).            
|            | 
|10.6        |  | Form of Subscription Agreement (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on December 8, 2006).                                                                                                                                     
|            | 
|14          |  | Code of Ethics of Orion Acquisition Corp. II (incorporated by reference to Exhibit 14 to the Annual Report on Form 10-KSB of Medivation, Inc. (formerly Orion Acquisition Corp. II) for the year
ended December 31, 2004).                                                  
|            | 
|21          |  | Subsidiaries of Medivation, Inc.                                                                                                                                                                                                                                            
|            | 
|23.1        |  | Consent of Independent Registered Public Accounting Firm.                                                                                                                                                                                                                   
|            | 
|31.1        |  | Certification pursuant to Rule 13a-14(a)/15d-14(a).                                                                                                                                                                                                                         
|            | 
|31.2        |  | Certification pursuant to Rule 13a-14(a)/15d-14(a).                                                                                                                                                                                                                         
|            | 
|32.1        |  | Certification pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                                   
|            | 
|32.2        |  | Certification pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                                   

---

|* | Management contract or compensatory plan or arrangement required to be filed as an exhibit to this Annual Report on Form 10-KSB.
|- | --------------------------------------------------------------------------------------------------------------------------------



|Item 14. | Principal Accountant Fees and Services.
|-------- | ---------------------------------------

The
information to be provided under the caption Principal Accountant Fees and Services, to be contained in the Definitive Proxy Statement and required to be disclosed in this Item 14, is hereby incorporated by reference in this
Item 14.



48



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SIGNATURES

In accordance with Section 13 or 15(d) of the Exchange Act, the registrant caused this Report
to be signed on its behalf by the undersigned, thereunto duly authorized.



MEDIVATION, INC.By:

/s/    C. PATRICK
MACHADOName:

C. Patrick MachadoTitle:

Senior Vice President and Chief Financial OfficerDate:

February 23, 2007


In accordance with the requirements of the Exchange Act, this Report has been signed by the
following persons on behalf of the registrant and in the capacities and on the dates indicated:



|                                               |  |                                                                                                |  |                  
|---------------------------------------------- |  | ---------------------------------------------------------------------------------------------- |  | -----------------
|/s/    DAVID T. HUNG,
M.D. David T. Hung, M.D. |  | President, Chief Executive Officer and Director (Principal Executive Officer)                  |  | February 23, 2007
|                                               |  |                                                                                               
|/s/    C. PATRICK
MACHADO C. Patrick Machado   |  | Senior Vice President and Chief Financial Officer (Principal Accounting and Financial Officer) |  | February 23, 2007
|                                               |  |                                                                                               
|/s/    DANIEL D.
ADAMS Daniel D. Adams         |  | Director                                                                                       |  | February 23, 2007
|                                               |  |                                                                                               
|/s/    GREGORY H.
BAILEY Gregory H. Bailey     |  | Director                                                                                       |  | February 23, 2007
|                                               |  |                                                                                               
|/s/    KIM D.
BLICKENSTAFF Kim D. Blickenstaff |  | Director                                                                                       |  | February 23, 2007
|                                               |  |                                                                                               
|/s/    W. ANTHONY
VERNON W. Anthony Vernon     |  | Director                                                                                       |  | February 23, 2007



49



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##### Table of Contents

EXHIBITS



|            |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
|----------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|2.1         |  | Agreement and Plan of Merger dated as of December 17, 2004, by and among the Orion Acquisition Corp. II, Medivation Acquisition Corp. and Medivation, Inc. (incorporated by reference to Exhibit
2.1 to the Current Report on Form 8-K of Medivation, Inc. (formerly Orion Acquisition Corp. II) filed on December 20, 2004).                                                                                                                                                                              
|            | 
|3.1(a)      |  | Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1(a) to the Quarterly Report on Form 10-QSB of Medivation, Inc. for the quarter ended June 30,
2005).                                                                                                                                                                                                                                                                                                            
|            | 
|3.1(b)      |  | Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1(b) to the Quarterly Report on Form 10-QSB of Medivation, Inc. for the
quarter ended June 30, 2005).                                                                                                                                                                                                                                                                                
|3.1(c)      |  | Certificate of Amendment to the Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1(c) to the Quarterly Report on Form 10-QSB of Medivation, Inc. for the
quarter ended June 30, 2005).                                                                                                                                                                                                                                                                            
|            | 
|3.2         |  | Bylaws of Medivation, Inc. (formerly Orion Acquisition Corp. II), together with all amendments and restatements thereto (incorporated by reference to Exhibit 3.2 to the Registration Statement on
Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-03252)).                                                                                                                                                                                                                   
|            | 
|4.1         |  | Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No.
333-03252)).                                                                                                                                                                                                                                                                                                                  
|            | 
|4.2         |  | Rights Agreement, dated as of December 4, 2006, between Medivation, Inc. and American Stock Transfer & Trust Company, as Rights Agent, which includes the form of Certificate of
Designations of the Series C Junior Participating Preferred Stock of Medivation, Inc. as Exhibit A, the form of Right Certificate as Exhibit B and the Summary of Rights to Purchase Preferred Shares as Exhibit C (incorporated by reference to Exhibit
4.1 to the Current Report on Form 8-K filed on December 4, 2006).
|            | 
|10.1(a)     |  | Registration Rights Agreement by and among Orion Acquisition Corp. II and Special Situations Fund III, L.P., Special Situations Cayman Fund, L.P. and Special Situations Private Equity Fund,
L.P., dated as of December 17, 2004 (incorporated by reference to Exhibit 10.3(a) to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                    
|            | 
|10.2(a)     |  | Warrant to purchase Common Stock of Medivation Neurology, Inc. assumed by Orion Acquisition Corp. II issued to Joseph J. Grano, Jr., dated as of June 8, 2004 (incorporated by reference to
Exhibit 10.5(a) to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                        
|            | 
|10.2(b)     |  | Warrant to purchase Common Stock of Medivation Neurology, Inc. assumed by Orion Acquisition Corp. II issued to Joseph J. Grano, Jr., dated as of August 1, 2004 (incorporated by reference to
Exhibit 10.5(b) to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                      
|            | 
|10.2(c)     |  | Warrant to purchase Common Stock of Medivation Neurology, Inc. assumed by Orion Acquisition Corp. II issued to Joseph J. Grano, Jr., dated as of September 1, 2004 (incorporated by reference to
Exhibit 10.5(c) to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                   
|            | 
|10.2(d)     |  | Amendment Agreement by and between Orion Acquisition Corp. II and Joseph J. Grano, Jr., dated as of December 17, 2004 (incorporated by reference to Exhibit 10.5(d) to the Registration
Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                                                                                                                                                                



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##### Table of Contents

|            |  |                                                                                                                                                                                                                                                                                                                                     
|----------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Exhibit Description                                                                                                                                                                                                                                                                                                                 
|            | 
|10.3        |  | Warrant to purchase Common Stock of Medivation Neurology, Inc. assumed by Orion Acquisition Corp. II issued to David T. Hung, M.D., dated as of November 16, 2004 (incorporated by reference
to Exhibit 10.6 to the Registration Statement on Form SB-2 of Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).
|            | 
|10.4(a)*    |  | 2004 Equity Incentive Plan of Medivation Neurology, Inc., assumed by Orion Acquisition Corp. II (incorporated by reference to Exhibit 10.7(a) to the Registration Statement on Form SB-2 of
Medivation, Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                               
|            | 
|10.4(b)     |  | Form of Stock Option Agreement of Medivation Neurology, Inc., assumed by Orion Acquisition Corp. II (incorporated by reference to Exhibit 10.7(b) to the Annual Report on Form 10-KSB of
Medivation, Inc. (formerly Orion Acquisition Corp. II) for the year ended December 31, 2004).                                              
|            | 
|10.4(c)     |  | Form of Stock Option Agreement of Medivation, Inc., assumed by Orion Acquisition Corp. II (incorporated by reference to Exhibit 10.7(c) to the Annual Report on Form 10-KSB of Medivation, Inc.
(formerly Orion Acquisition Corp. II) for the year ended December 31, 2004).                                                        
|10.5        |  | Agreement by and between QS Pharma, LLC and Medivation, Inc., dated as of January 11, 2005 (incorporated by reference to Exhibit 10.9(b) to the Registration Statement on Form SB-2 of Medivation,
Inc. (formerly Orion Acquisition Corp. II) (No. 333-122431)).                                                                    
|            | 
|10.6        |  | Form of Subscription Agreement (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on December 8, 2006).                                                                                                                                                                                             
|            | 
|14          |  | Code of Ethics of Orion Acquisition Corp. II (incorporated by reference to Exhibit 14 to the Annual Report on Form 10-KSB of Medivation, Inc. (formerly Orion Acquisition Corp. II) for the year
ended December 31, 2004).                                                                                                          
|            | 
|21          |  | Subsidiaries of Medivation, Inc.                                                                                                                                                                                                                                                                                                    
|            | 
|23.1        |  | Consent of Independent Registered Public Accounting Firm.                                                                                                                                                                                                                                                                           
|            | 
|31.1        |  | Certification pursuant to Rule 13a-14(a)/15d-14(a).                                                                                                                                                                                                                                                                                 
|            | 
|31.2        |  | Certification pursuant to Rule 13a-14(a)/15d-14(a).                                                                                                                                                                                                                                                                                 
|            | 
|32.1        |  | Certification pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                                                                                           
|            | 
|32.2        |  | Certification pursuant to Section 1350 of the Sarbanes-Oxley Act of 2002.