United States Chemical Safety June 2011

Environmental Protection and Pollution Prevention

Agency (7510P)

Glycolic Acid And Salts

Summary Document:

Registration Review: Initial Docket

June 2011
Docket Number: EPA-HQ-OPP-2011-0422 

www.regulations.gov 

Glycolic Acid And Salts 

Summary Document 

Registration Review: Initial Docket 

May 2011 

Case # 4045 

Approved By: 

- Dan arrigan-Farrelly 

Director, Antimicrobials Division 

Date: 

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TABLE OF CONTENTS

Glycolic Acid And Salts Registration Review Team ..........................................................4

I. Preliminary Work Plan .....................................................................................................5

II. Fact Sheet ......................................................................................................................11

III. Summary of Anticipated Data Requirements..............................................................15

IV. Appendix A..................................................................................................................16

________________________________________

Please Note

This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's 

current position based on the following documents:

1. Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the 

Glycolic acid Registration Review Decision Document. June 7, 2011

2. Summary of Human Health Effects Data for the Glycolic Acid Registration Review 

Decision Document. May 31, 2011

Additional supporting documents for the Glycolic Acid And Salts Case may be found in the 

registration review docket EPA-HQ-OPP-2011-0422 located on the internet at

www.regulations.gov.
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Glycolic Acid And Salts Registration Review Team

Human Health & Environmental Effects

Nathan Mottl

Srinivas Gowda

Risk Management

Seiichi Murasaki

Lance Wormell

Office of General Counsel

Philip Ross
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I. Preliminary Work Plan -- Glycolic Acid And Salts

Introduction:

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review program. All 

pesticides distributed or sold in the United States generally must be registered by the U.S. 

Environmental Protection Agency (USEPA, EPA, or the Agency) based on scientific data 

showing that they will not cause unreasonable risks to human health or the environment when 

used as directed on product labeling. The registration review program is intended to make sure 

that, as the ability to assess risk evolves and as policies and practices change, all registered 

pesticides continue to meet the statutory standard of no unreasonable adverse effects to human 

health or the environment. Changes in science, public policy, and pesticide use practices will 

occur over time. Through the registration review program, the Agency periodically reevaluates 

pesticides to make sure that as change occurs, products in the marketplace can be used safely. 

Information on this program is provided at http://www.epa.gov/oppsrrd1/registration_review/.

The Agency is implementing the registration review program pursuant to Section 3(g) of the 

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered 

pesticide every 15 years to determine whether it continues to meet the FIFRA standard for 

registration. The Agency will consider benefits information and data as required by FIFRA. The 

public phase of registration review begins when the initial docket is opened for each case. The 

docket is the Agency’s opportunity to state what it knows about the pesticide and what additional 

risk analyses and data or information it believes are needed to make a registration review 

decision. After reviewing and responding to comments and data received in the docket during 

this initial comment period, the Agency will develop and commit to a final work plan and 

schedule for the Glycolic Acid And Salts Case.

The Glycolic Acid and Salts case (Case 4045) contains two active ingredients, glycolic acid (PC 

Code 000101) and sodium glycolate (PC Code 000103). Glycolic acid is the only active 

ingredient in the case with registered products. The last product containing sodium glycolate 

was canceled in 1989. There are no registered pesticide products containing sodium glycolate 

and therefore sodium glycolate will not be addressed in this registration review at this time.

The first product containing glycolic acid (PC Code 000101) as an active ingredient was 

registered in the United States in 2001. Currently, there are eight products registered with EPA.

Glycolic acid is registered as a disinfecting cleaner and a disinfectant/sanitizer for non-food 

contacting, hard non-porous surfaces in residential and public access premises. There are no 

tolerances, exemptions from tolerances, or tolerance petitions for this antimicrobial pesticide. 

Glycolic acid is approved by FDA as an indirect food additive for use in food packaging 

adhesives (175.105). Furthermore, human dietary exposure to residues of glycolic acid pesticidal 

sources is expected to be minimal compared to cosmetic uses and naturally-occurring residues 

(especially in sugar cane, sugar beets, and several fruits). The only expected labeled use pattern 

that could potentially lead to dietary exposure is indirect food contact from countertops in 

residential homes. During applications on countertops, formulations are typically diluted and the 

label states that all food must be removed prior to application, and surfaces must be rinsed with 

potable water following application. Although residues of glycolic acid on countertops after 

potable water rinses are not expected to concentrate on food products and exposure will be 
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minimal, EPA will perform risk assessments to determine if tolerances or exemptions from 

tolerances will be needed to support the existing registered uses of glycolic acid..

A Reregistration Eligibility Decision (RED) was not completed for glycolic acid because it was 

registered after November 1, 1984.

Documents associated with the registration review of Glycolic acid and salts can be viewed at 

www.regulations.gov in docket EPA-HQ-OPP-2011-0422. Below is a summary of the issues 

relevant to this registration review case.

Anticipated Risk Assessment and Data Needs:

The Agency does not anticipate the need to conduct an ecological risk assessment. The Agency 

anticipates the need to conduct a human health risk assessment. The Agency anticipates needing 

additional data to conduct the registration review for glycolic acid.

Ecological Risk:

Based on the low hazard and exposure, the Agency concludes that the registered uses of 

glycolic acid will have 'no effect' (NE) on endangered or threatened terrestrial or aquatic 

species, or their designated critical habitats, as listed by the U.S. Fish and Wildlife 

Service (USFWS) and the National Oceanic and Atmospheric Administration's (NOAA) 

National Marine Fisheries Service (NMFS). EPA anticipates conducting no further 

analysis of potential risks to endangered or threatened species unless public comment 

provides data or information that would otherwise inform the Agency's determination.

The Agency does not anticipate the need to require additional ecological data for this

registration review at this time.

The Agency does not anticipate the need to require additional environmental fate data for 

this registration review at this time.

For more information, please refer to Summary of Product Chemistry, Environmental 

Fate, and Ecotoxicity Data for the Glycolic acid Registration Review Decision 

Document, located in the docket.

Human Health Risk: 

The most recent human health assessments for glycolic acid were completed in 1997 to

support the initial registration based on the proposed use as a toilet bowl disinfectant.

The Agency anticipates the need to require the following additional human health data 

for use in the registration review of all registered uses of glycolic acid.

870.3465 -- 90-day inhalation toxicity (rat)

875.1200 -- Dermal indoor exposure

875.1400 -- Inhalation indoor exposure

875.1600 -- Application exposure data reporting and calculations
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875.1700 -- Product use information

875.2300 -- Indoor surface residue dissipation

875.2800 -- Description of human activity

875.3000 -- Nondietary ingestion exposure

For more information, please refer to Summary of Human Health Effects Data for the 

Glycolic Acid Registration Review Decision Document, located in the docket.

Product Chemistry:

The Agency does not anticipate the need to require additional product chemistry data for 

this registration review at this time.

For more information, please refer to Summary of Product Chemistry, Environmental 

Fate, and Ecotoxicity Data for the Glycolic acid Registration Review Decision 

Document, located in the docket.

Endocrine Disruptor Screening Program

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse 

outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and 

chronic toxicity, including assessments of carcinogenicity, neurotoxicity, developmental, 

reproductive, and general or systemic toxicity. These studies include endpoints which may be 

susceptible to endocrine influence, including effects on endocrine target organ histopathology, 

organ weights, estrus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, 

and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and 

chronic studies that assess growth, developmental and reproductive effects in different 

taxonomic groups. As part of its most recent registration decision, EPA reviewed these data and 

selected the most sensitive endpoints for relevant risk assessment scenarios from the existing 

hazard database. However, as required by FFDCA section 408(p), glycolic acid is subject to the 

endocrine screening part of the Endocrine Disruptor Screening Program (EDSP). 

EPA has developed the EDSP to determine whether certain substances (including pesticide 

active and other ingredients) may have an effect in humans or wildlife similar to an effect 

produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator 

may designate.” The EDSP employs a two-tiered approach to making the statutorily required 

determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a 

chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal 

systems. Chemicals that go through Tier 1 screening and are found to have the potential to 

interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA 

will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 

testing is designed to identify any adverse endocrine-related effects caused by the substance, and 

establish a dose-response relationship between the dose and the E, A, or T effect.

Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between October 

2009 and February 2010, EPA issued test orders/data call-ins for the first group of 67 chemicals, 

which contains 58 pesticide active ingredients and 9 inert ingredients. Glycolic acid is not among 
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the group of 58 pesticide active ingredients on the initial list to be screened under the EDSP.

Accordingly, as part of registration review, EPA will issue future EDSP orders/data call-ins, 

requiring the submission of EDSP screening assays for glycolic acid. For further information on 

the status of the EDSP, the policies and procedures, the list of 67 chemicals, future lists, the test 

guidelines and the Tier 1 screening battery, please visit our website: http://www.epa.gov/endo/.

Timeline

EPA has created the following estimated timeline for the completion of the Glycolic acid and 

salts registration review:

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket

Open Public Comment Period for Docket June 2011

Close Public Comment Period for Docket August 2011

Phase 2: Case Development

Develop Final Work Plan (FWP) December 2011

Issue DCI December 2012

Data Submission December 2014

Open Public Comment Period for Preliminary Risk Assessments June 2016

Close Public Comment Period for Preliminary Risk Assessments September 2016

Phase 3: Registration Review Decision

Open Public Comment Period for Proposed Reg. Review Decision December 2016

Close Public Comment Period for Proposed Reg. Review Decision March 2017

Final Decision and Begin Post-Decision Follow-up 2017

Total (years) 6

Guidance for Commenters:

The public is invited to comment on EPA’s Preliminary Work Plan and rationale. The Agency 

will carefully consider all comments as well as any additional information or data provided in a 

timely manner prior to issuing a final work plan for the Glycolic acid and salts registration 

review case.

Trade Irritants:

Through the registration review process, the Agency intends to solicit information on trade 

irritants and, to the extent feasible, take steps toward facilitating irritant resolution. Growers and 

other stakeholders are asked to comment on any trade irritant issues resulting from lack of 

Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key 

export markets, providing as much specificity as possible regarding the nature of the concern.
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Water Quality:

Glycolic acid is not identified as a cause of impairment for any water bodies listed as impaired 

under section 303(d) of the Clean Water Act, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=88

5. In addition, no Total Maximum Daily Loads (TMDL) have been developed for glycolic acid, 

based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_group_id

=885&p_pollutant_group_name=PESTICIDES.

More information on impaired water bodies and TMDLs can be found at 

http://www.epa.gov/owow/tmdl/. The Agency invites submission of water quality data for this 

pesticide. To the extent possible, data should conform to the quality standards in Appendix A of 

the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water 

Quality Data in OPP’s Registration Review Risk Assessment and Management Process (see: 

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm), in order to ensure the 

data can be used quantitatively or qualitatively in pesticide risk assessments.

Environmental Justice:

EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all 

people, regardless of race, color, national origin, or income, in the development, implementation, 

and enforcement of environmental laws, regulations, and policies. To help address potential 

environmental justice issues, the Agency seeks information on any groups or segments of the 

population who, as a result of their location, cultural practices, or other factors, may have 

atypical, unusually high exposure to glycolic acid compared to the general population. Please 

comment if you are aware of any sub-populations that may have atypical, unusually high 

exposure compared to the general population.

Structure Activity Relationships: 

EPA must rely upon information of appropriate quality and reliability for each decision made by 

the Agency. In the Office of Pesticide Programs (OPP), the evaluation process for a pesticide 

chemical traditionally begins with the applicant’s submission of a set of studies conducted with 

the specific pesticide chemical of interest. The use of the results of such testing (measured data) 

is a logical, scientifically rigorous process that identifies the physical, chemical, and 

environmental fate properties of the pesticide, as well as the dose and endpoints at which an 

adverse effect can occur in various animal species. 

Today, there is significant interest in alternative techniques, i.e., techniques other than data 

generation that could significantly inform the Agency’s decision-making process. Recently, OPP 

has made increasing use of structure activity relationship (SAR) as part of its regulatory 

decision-making process. In the SAR process, a chemical's molecular structure is compared to 

that of other chemicals for which data are available. These structural similarities are then used to 

make predictive judgments about a chemical’s physical, chemical, and biological properties. 

Thus, the chemical’s physical, chemical, and biological properties are a function of (or directly 

related to) the chemical’s molecular structure. Quantitative SAR is referred to as QSAR. To 
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develop a QSAR, a selected set of measured data on a single physical, chemical, or biological 

property is used to derive a model (an equation) to predict the value of that property. 

Since SAR assessments and QSAR modeling are another set of tools that are available to Agency 

scientists, OPP has begun a process shift that envisions shifting from the current study-by-study 

approach to an approach in which the use of predicted data, generated using validated models, is 

considered along with information from open literature and studies specifically generated under 

Part 161 requirements. All relevant information would be considered as part of a weight-of-theevidence evaluation. 

At this time, EPA believes that for certain endpoints, especially physical/chemical and fate 

properties, that SAR and QSAR might be effectively utilized to fulfill these data requirements 

for many antimicrobial pesticide chemicals. When considering biological properties, at this time, 

EPA believes that SAR and QSAR can be most effectively utilized in the evaluation of 

chemicals that exhibit lower toxicity for human health and/or ecotoxicity parameters. This is 

appropriate because the risk assessment for lower toxicity chemicals can be stream-lined, i.e., a 

screening-level assessment procedure rather than multiple tiers of assessments with progressively 

more data requirements.

If stakeholders believe that submission of predicted data can fulfill one of the data needs for the 

Glycolic Acid And Salts Case, then the Agency invites submission of this information. The 

submitter would be expected to supply a rationale describing the utility of the information and 

provide documentation on the scientific validity of the information. The determination that the 

predicted data fulfills the data requirement would be at the sole discretion of the Agency. Presubmission consultation with the Agency is encouraged.

Additional Information:

Stakeholders are also specifically asked to provide available information and data that will assist 

the Agency in refining its risk assessments, including any species-specific ecological effects 

determinations. The Agency is interested in receiving the following information:

1. Confirmation on the following label information:

a. Sites of application

b. Formulations

c. Application methods and equipment

d. Maximum application rates

e. Frequency of application, application intervals and maximum number of 

applications

f. Geographic limitations on use

2. Use or potential use distribution

3. Use history

4. Usage/use information for non-agricultural uses (e.g., materials preservation)

5. Typical application interval

6. State or local use restrictions

7. Ecological incidents (non-target plant damage and avian, fish, reptilian, amphibian 

and mammalian mortalities) not already reported to the Agency
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8. Monitoring data

Next Steps:

After the 60-day comment period closes in August 2011, the Agency will review and respond to 

any comments received in a timely manner, and then issue a Final Work Plan for the Glycolic 

Acid And Salts Case. 
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II. Fact Sheet

Background Information:

Active Ingredient: glycolic acid

Case number: 4045

PC Code: 000101

CAS number: 79-14-1

Technical registrants: E. I. du Pont de Nemours and Company

First approved for use in a registered product: 2001

There are no tolerances, exemptions from tolerances, or tolerance petitions for this 

antimicrobial pesticide. Glycolic acid is approved by FDA as an indirect food additive for 

use in food packaging adhesives (175.105). Furthermore, human dietary exposure to 

residues of glycolic acid pesticidal sources is expected to be minimal compared to 

cosmetic uses and naturally-occurring residues (especially in sugar cane, sugar beets, and 

several fruits). 

Antimicrobials Division Chemical Review Manager (CRM): Seiichi Murasaki, 

murasaki.seiichi@epa.gov

Antimicrobials Division Product Manager (PM): Wanda Henson, 

henson.wanda@epa.gov

Chemical Structure: 

Use & Usage Information:

Glycolic acid is registered as a disinfecting cleaner and a disinfectant/sanitizer for nonfood contacting, hard non-porous surfaces in residential and public access premises.

Ecological Risk Assessment Status:

Please refer to Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for 

the Glycolic acid Registration Review Decision Document, located in the docket, for a detailed 

discussion of the ecological risk assessments.

Based on available environmental fate and ecotoxicity data for glycolic acid, EPA 

believes that the currently registered use pattern of glycolic acid as a disinfectant/sanitizer 

for hard non-porous surfaces in homes will not cause unreasonable adverse effects on the 

environment, and is not anticipated to cause adverse effects on fish, invertebrates, plants 

or other wildlife.

Human Health Risk Assessment Status:

The following are key findings of the recent human health risk assessments for Glycolic acid and 

salts. Please refer to Summary of Human Health Effects Data for the Glycolic Acid Registration 
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Review Decision Document, located in the docket, for a detailed discussion of the human health 

risk assessment.

Hazard Characterization:

Acute dermal, dermal irritation, and eye toxicity studies were waived during registration 

based on a low pH (<2) and the expected corrosivity of the product; these three default to 

Toxicity Category I.

Oral toxicity was assigned Category III, and acute inhalation toxicity was assigned 

Category IV, based on studies in mice.

Glycolic acid was determined not to be a dermal sensitizer based on a modified Draize 

test.

Dietary (Food and Water):

A dietary risk assessment was not conducted during the intial registration since the 

Agency did not expect dietary exposure to glycolic acid resulting from the proposed toilet 

bowl disinfectant use.

Glycolic acid is approved by FDA as an indirect food additive for use in food packaging 

adhesives (175.105). Furthermore, human dietary exposure to residues of glycolic acid 

pesticidal sources is expected to be minimal compared to cosmetic uses and naturallyoccurring residues (especially in sugar cane, sugar beets, and several fruits). 

The only expected labeled use pattern that could potentially lead to dietary exposure is 

indirect food contact from countertops in residential homes. During applications on 

countertops, formulations are typically diluted and the label states that all food must be 

removed prior to application, and surfaces must be rinsed with potable water following 

application. Although residues of glycolic acid on countertops after potable water rinses 

are not expected to concentrate on food products and exposure will be minimal, EPA will 

conduct a dietary food assessment for this use. 

According to the environmental fate data, glycolic acid is expected to be readily 

biodegradable in the environment. Glycolic acid is also expected to be diluted when it is 

flushed down the drain and resulting concentrations in drinking water are not expected to 

be above background levels found in the environment.

Residential:

A residential risk assessment was not conducted during initial registration because 

exposure was expected to be minimized based on the proposed use as a toilet bowl 

disinfectant.
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With additional uses (e.g., countertop disinfectant and laundry use) there is a potential for 

short-term dermal and inhalation application exposure to homeowners while using 

aerosol sprays and trigger pump sprays and while open-pouring and mopping.

Aggregate:

The Agency has not conducted an aggregate risk assessment for glycolic acid.

In examining aggregate exposure, EPA takes into account the available and reliable 

information concerning exposures to glycolic acid residues in food and drinking water, 

and non-occupational pesticide exposures. Only residential risks associated with aerosol 

spray, trigger pump spray, open pouring, and mopping dermal and inhalation exposures 

as well as possible dietary exposure and post-application hand-to-mouth exposure from 

treated countertops and mouthing treated fabrics are expected to be aggregated.

Occupational:

An occupational risk assessment was not conducted during initial registration because 

exposure was expected to be minimized based on the proposed use as a toilet bowl 

disinfectant.

With additional uses (e.g., hard surface disinfectant and laundry use) there is a potential 

for short-term dermal and inhalation application exposure to occupational worker while 

using aerosol sprays and trigger pump sprays and while open-pouring and mopping.

Cumulative:

EPA does not have, at this time, available data to determine whether glycolic acid has a 

common mechanism of toxicity with other substances or how to include this pesticide in 

a cumulative risk assessment. For the purposes of this Registration Review, EPA has 

assumed that glycolic acid does not have a common mechanism of toxicity with other 

substances when used as an antimicrobial as registered.

Incidents:

Ecological:

No glycolic acid ecological incidents have been reported in the Ecological Incident 

Information System (EIIS), maintained by the Environmental Fate and Effects Division 

(EFED) of the Agency.

Human Health:

No glycolic acid human poisoning incidents have been reported in the OPP Incident Data 

System (IDS).
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Tolerances and International Harmonization:

There are no tolerances, exemptions from tolerances, or tolerance petitions for this 

antimicrobial pesticide. 

Glycolic acid is approved by FDA as an indirect food additive for use in food packaging 

adhesives (175.105). Furthermore, human dietary exposure to residues of glycolic acid 

pesticidal sources is expected to be minimal compared to cosmetic uses and naturallyoccurring residues (especially in sugar cane, sugar beets, and several fruits). 

The only expected labeled use pattern that could potentially lead to dietary exposure is 

indirect food contact from countertops in residential homes. During applications on 

countertops, formulations are typically diluted and the label states that all food must be 

removed prior to application, and surfaces must be rinsed with potable water following 

application. Although residues of glycolic acid on countertops after potable water rinses 

are not expected to concentrate on food products and exposure will be minimal, EPA will 

perform risk assessments to determine if tolerances or exemptions from tolerances will be 

needed to support the existing registered uses of glycolic acid.

Data Call-In Status:

There are no outstanding data call-in (DCI) requirements for glycolic acid.

Labels:

Registered products, including EPA registration numbers are provided in Table 1 below. For 

future reference, during registration review a list of product registration numbers will be included 

in the docket. Product registration labels may be obtained from the Pesticide Product Label 

System (PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home.

Table 1. Registered Products – Glycolic Acid

Registration # Registration Name Company Name Formulation Type % 

A.I.

5813-80 Clorox Patch The Clorox Company Soluble Concentrate 1.5

5813-86 CBW The Clorox Company Impregnated Materials 11.185

5813-87 X-Men The Clorox Company Ready-to-Use Solution 3.07

5813-93 Show The Clorox Company Impregnated Materials 11.185

5813-101 Tuck 3 The Clorox Company Ready-to-Use Solution 1.75

71654-1 DuPont Glyclean AM E.I. du Pont de Nemours and 

Company

Formulation 

Intermediate 68

71654-2 DuPont Bowl Cleaner E.I. du Pont de Nemours and 

Company Ready-to-Use Solution 9.5
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Registration # Registration Name Company Name Formulation Type % 

A.I.

71654-5 DuPont KleanIt E.I. du Pont de Nemours and 

Company Ready-to-Use Solution 5.0
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III. Summary of Anticipated Data Requirements – Glycolic Acid And Salts

The table below summarizes anticipated data needs for the Glycolic Acid And Salts Case in 

Section I of this document (Preliminary Work Plan), Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Glycolic acid Registration Review Decision 

Document, and Summary of Human Health Effects Data for the Glycolic Acid Registration 

Review Decision Document.

Table 2. Summary of Anticipated Data Requirements – Glycolic Acid

Guideline

Number Anticipated Data Requirement Test Material

Estimated

Timeframe 

(Measured in 

months from DCI 

Receipt)

875.1200 Dermal indoor exposure TGAI 24

875.1400 Inhalation indoor exposure TGAI 24

875.1600 Application exposure data reporting and calculations TGAI 12

875.1700 Product use information TGAI 12

875.2300 Indoor surface residue dissipation TGAI 24

875.2800 Description of human activity TGAI 12

875.3000 Nondietary ingestion exposure TGAI 24

870.3465 90-day inhalation toxicity TGAI 24
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IV. Appendix A: Use Patterns – Glycolic acid and salts

EPA 

Reg. #

Treatment Site Method of 

Application

Application Rate/ 

No. of 

applications

Use Limitations

Use Category – Residential and Public Access Premises

Use Site – Hard, Nonporous Surfaces

5813-80 

Sinks, stovetops, 

refrigerator exteriors, 

range hoods, kitchen 

appliance exteriors,

baby furniture, toilet 

bowl exteriors, urinal 

exteriors, tubs, diaper 

pails, high chairs (nonfood contact areas)

Spray spray until wet, 30 

second contact 

time to sanitize, 10 

minutes to 

disinfect

Do not use on floors, do not use on 

cookware

5813-86 

Sinks, stovetops, 

refrigerator exteriors, 

range hoods, kitchen 

appliance exteriors,

baby furniture, toilet 

bowl exteriors, urinal 

exteriors, tubs, diaper 

pails, high chairs (nonfood contact areas)

sponge, wipe wipe until wet, 5 

minutes contact 

time to sanitize, 10 

minutes to 

disinfect

Do not use on floors, do not use on 

cookware. Moisten impregnated 

pad to release end use product.

5813-87 

Toilet bowl interiors spray Apply under and 

around rim of 

toilet bowl, 5 

minute contact 

time.

5813-93 

Toilet bowl interiors sponge, wipe Scrub entire bowl 

below water line, 5 

minute contact 

time.

5813-101

Sinks, stovetops, 

refrigerator exteriors, 

range hoods, kitchen 

appliance exteriors, 

baby furniture, toilet 

bowl exteriors, urinal 

exteriors, tubs, diaper 

pails, high chairs (nonfood contact areas)

sponge, wipe wipe until wet, 10 

minutes to 

disinfect

If used on food preparation 

surfaces, the application must be 

followed by a potable water rinse.

Do not use on marble, aluminum, or 

wood that is unfinished, unsealed, 

unpainted, waxed, oiled or worn.

71654-1 

For use in the 

formulation of liquid 

antimicrobial cleaning 

products

For formulation of antimicrobial 

cleaners for use in household, 

industrial, institutional, 

commercial, & agricultural 

premises, and on food processing 

facilities and equipment, use up to 

20% glycolic acid by weight (100% 

basis) in an aqueous solution. 

Formulation should be performed 

using a closed system. 

71654-2 

Toilet bowl interiors spray Apply at least two 

ounces under and 
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EPA 

Reg. #

Treatment Site Method of 

Application

Application Rate/ 

No. of 

applications

Use Limitations

around rim of 

toilet bowl, 10 

minute contact 

time.

71654-5 

Sinks, stovetops, 

refrigerator exteriors, 

range hoods, kitchen 

appliance exteriors,

baby furniture, toilet 

bowl exteriors, urinal 

exteriors, tubs, diaper 

pails, high chairs (nonfood contact areas)

Spray spray until wet 10 

minute contact 

time to disinfect

If used on food preparation 

surfaces, all food must be removed 

prior to application and the 

application must be followed by a 

potable water rinse

Use Category – Residential and Public Access Premises

Use Site – Fabric and Upholstery

5813-101

Laundry Pour Rub in full 

strength on grease 

spots or heavily 

soiled areas before 

washing; for extra 

cleaning, add 1/2 

cup to load.

Use only on white or colorfast 

fabrics.