Exhibit 10.4



 Exhibit 10.4 
  
 SERVICES AGREEMENT 
  
 THIS SERVICES AGREEMENT (this “Agreement”) is made and entered into as of the 10th day of August, 2004 by and between Third Security, LLC, a Virginia limited liability company (“THIRD SECURITY”), and New River
Pharmaceuticals Inc., a Virginia corporation, including all of its now or hereafter existing subsidiaries (“NEW RIVER”). 
  
 WHEREAS, NEW RIVER intends to pursue an underwritten initial public offering (the closing of which is hereafter referred to as the
“Offering”); 
  
 WHEREAS, historically
THIRD SECURITY has provided certain corporate and administrative services to its affiliates, including NEW RIVER; and 
  
 WHEREAS, THIRD SECURITY and NEW RIVER desire that THIRD SECURITY continue to provide certain services to NEW RIVER through and following the
Offering pursuant to the terms and conditions of this Agreement. 
  
 NOW, THEREFORE, in consideration of the mutual promises and covenants herein contained and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties to this Agreement,
intending to be bound hereby, agree as follows: 
  
 1. Services.
Following the Offering, THIRD SECURITY will provide or cause to be provided to NEW RIVER, those corporate and administrative services described in Exhibit A hereto (the “Services”), as requested by NEW RIVER from time to
time. The scope of the Services may be adjusted by the mutual agreement of the parties hereto. 
  
 2. Charges for Services. As consideration for the Services provided hereunder, NEW RIVER agrees to pay the following fees and expenses to THIRD SECURITY: 
  
 (a) Fees for Services performed for NEW RIVER by a vendor,
contractor or similar third party (other than THIRD SECURITY) shall be equal to the final invoiced costs charged by such third party to THIRD SECURITY for the performance of such Services. 
  
 (b) With respect to all other Services provided by THIRD
SECURITY employees, NEW RIVER will pay to THIRD SECURITY an hourly rate calculated as follows for each THIRD SECURITY employee providing Services in a given invoice period under this Agreement: such hourly rate shall equal [the annual salary of the
THIRD SECURITY employee performing the given Services plus a thirty percent (30%) markup to cover the cost of overhead and fringe benefits provided to such THIRD SECURITY employee] divided by 2,080 hours. In addition, NEW RIVER will pay reasonable
travel and other out-of-pocket expenses incurred in connection therewith. 
  
 (c) All travel and out-of-pocket expenses of THIRD SECURITY made in accordance with the then effective policies of THIRD SECURITY governing such expenses will be deemed reasonable and may not be subject to any
dispute. 







 3. Payments. 
  
 (a) THIRD SECURITY shall submit to NEW RIVER by the fifteenth (15th) day of each month an invoice for all charges associated with Services provided during the preceding month, including any other amounts payable in respect of
prior invoice periods. All invoices shall reference the Services provided and the charges associated therewith, any related adjustments and any other amounts that are payable. Except as provided in subparagraph (b) below, NEW RIVER shall remit
payment in full for all charges invoiced on or before the last business day of the month in which the invoice is received. Payment of all invoices shall be made by check or electronic funds transfer of immediately available funds to an account or
accounts designated by THIRD SECURITY. Any late payment shall bear interest at the rate of one half percent (0.5%) per month or fraction thereof until paid. 
  
 (b) In the event of a dispute as to an invoiced amount, NEW RIVER shall promptly pay all undisputed amounts, but shall be entitled to
withhold amounts in dispute, and shall promptly notify THIRD SECURITY of such dispute and the basis therefor. The parties agree to provide each other with sufficient records and information to resolve such dispute and, without limiting the rights
and remedies of the parties hereunder, to negotiate in good faith a resolution thereto. Notwithstanding this clause (b), the late payment interest provision in Section 3(a) shall apply to all such withheld amounts that are ultimately determined to
be due and payable, which amounts, including any interest, shall be promptly remitted to THIRD SECURITY in the manner provided herein. 
  
 4. Term of Agreement. The term of this Agreement shall commence immediately upon the date hereof and continue for a period of twenty four (24) months unless
terminated by agreement of the parties hereto (except with respect to the services identified in Paragraph 7 of Exhibit A, which shall be provided until December 30, 2007). Notwithstanding the foregoing this Agreement shall become terminable at any
time by NEW RIVER upon delivery of written notice to THIRD SECURITY with respect to any Services or any part thereof. Termination under this Section 4 or otherwise shall have no effect on the obligations of the parties to provide Services prior to
the effective date of such termination or to make payments in respect of charges incurred in connection therewith or which relate to events occurring prior to such date. 
  
 5. Performance of Services. 
  
 (a) THIRD SECURITY shall perform the Services or cause the Services to be performed with the same degree of care, skill, timeliness and
prudence customarily exercised with respect to its own operations. It is understood and agreed that the Services will be substantially identical in nature and quality to the Services performed by THIRD SECURITY for NEW RIVER during the year prior to
the commencement of the term of this Agreement, except with respect to such services required to effect the Offering. 
  
 (b) Each party acknowledges that the Services will be provided only with respect to NEW RIVER’s business. Services will not be
requested for the benefit of any entity other than NEW RIVER. NEW RIVER agrees that it will use the Services only in accordance with all applicable federal, state and local laws, and regulations and in accordance with the reasonable conditions,
rules, regulations and specifications which are or may be set forth in any manuals, materials, documents or instructions of THIRD SECURITY. THIRD SECURITY reserves the right to take all actions, including the termination of any Services or part
thereof, in order to ensure that the Services are provided in accordance with any applicable laws and regulations. 
  
 (c) Any input or information needed by either party to perform or utilize the Services pursuant to the provisions of this Agreement shall
be provided by the other party in a manner consistent with the practices employed by the parties during the year prior to the date of this Agreement. Should the failure by NEW RIVER to provide such input or information render the performance of the
Services impossible or unreasonably difficult, THIRD SECURITY may, upon reasonable notice, refuse to provide such Services. 
  

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 6. Liability and Indemnification. Except as provided below, THIRD SECURITY and all of its managing
directors, officers, agents and employees shall have no liability, whether direct or indirect, in contract, tort or otherwise, under this Agreement for any damage, loss or other harm (including, without limitation, out-of-pocket expenses and fees
and disbursements of counsel) of any type suffered by NEW RIVER or any third party in connection with the performance or non-performance of this Agreement or the Services contemplated hereby or any action or in-action of any of the indemnified
parties in connection with the foregoing, except for any such damage, loss or other harm directly caused by or directly resulting from the gross negligence or willful misconduct of THIRD SECURITY in connection with the performance or non-performance
of this Agreement or the Services contemplated hereby or the action or inaction of any of the indemnified parties in connection with the foregoing. In the event of a third party claim, NEW RIVER, including its successors and assigns, for itself and
on behalf of all of its subsidiaries, shall indemnify, defend and hold harmless THIRD SECURITY and all of its managing directors, officers, agents and employees from and against any and all such damages, losses and other harms (including, without
limitation, out-of-pocket expenses and fees, counsel fees and disbursements of counsel) caused by or arising out of the performance or non-performance of this Agreement or the Services contemplated hereby or the actions or in-actions of any of the
indemnified parties in connection with the foregoing other than any such damage, loss or other harm directly caused by or directly resulting from the gross negligence or willful misconduct of THIRD SECURITY in connection with the performance or
non-performance of this Agreement or the Services contemplated hereby or the actions or in-actions of any of the indemnified parties in connection with the foregoing. The total liability of THIRD SECURITY under this Section 6 will not under any
circumstances exceed the aggregate amount of actual fees paid to THIRD SECURITY by NEW RIVER pursuant to this Agreement. Notwithstanding any other provision of this Agreement, THIRD SECURITY shall have no liability for (i) any lost profits or any
incidental, consequential, special, indirect or similar damages of any kind or nature whatsoever of NEW RIVER or any third party (including the fees and expenses of counsel) or (ii) the acts or omissions of any third party (other than THIRD
SECURITY) that provides Services hereunder. This Section 6 shall survive the termination of this Agreement until such time as the obligations of the parties (including their respective successors and assigns) set forth in this Section 6 have been
fully satisfied. 
  
 7. Confidentiality. The parties each agree to
hold in trust and maintain confidential, and, except as required by law or applicable rules and regulations promulgated thereunder or by court order or other legal process, not to disclose to others without first obtaining the prior written approval
of the other party, any information received by it from the other party or developed or otherwise obtained by it under this Agreement, including all information resulting from the provision or utilization of the Services hereunder (collectively, the
“Information”). At the time of termination of this Agreement in whole or in part, each party shall, within 90 days after the effective date of such termination, return to each other all written Information that it obtained and shall not
retain or allow any third party to retain photocopies or other reproductions of such Information, provided that (i) the parties may retain any Information to the extent reasonably needed to comply with applicable tax, accounting or financial
reporting requirements or to resolve any legal issues identified at the time of termination, and (ii) in the case of a partial termination of this Agreement, the parties may retain any Information required to perform or utilize any remaining
Services covered by this Agreement. Alternatively, each party may, upon receipt of the written consent of the other party, destroy such Information instead of returning the same pursuant to the foregoing sentence. The obligations set forth in this
Section 7 shall not apply to any Information that is shown by either party to be or have become knowledge generally available to the public other than through the acts or omissions of such party. 
  

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 8. Assignment. Neither party shall assign or transfer any of its rights or delegate any of its obligations
under this Agreement without first obtaining the prior written consent of the other party, which consent may be withheld by such other party in its sole discretion; provided that THIRD SECURITY shall be permitted to cause any Services to be provided
or caused to be provided by THIRD SECURITY through one or more third parties selected by THIRD SECURITY; and provided further that the selection of any third party by THIRD SECURITY shall be subject to the prior written consent of NEW RIVER (which
shall not be unreasonably withheld or delayed) unless such third party shall have provided the same or similar Services to THIRD SECURITY at any time during the twelve (12) months immediately preceding the date of this Agreement. This Agreement
shall be binding upon and inure to the benefit of the parties hereto and their successors and permitted assigns. 
  
 9. Notices. All notices and other communications hereunder shall be in writing and shall be delivered in person, by United States mail, certified, return
receipt requested, postage prepaid, by express mail by a nationally recognized carrier, or by facsimile transmission (provided, if sent by facsimile transmission, such notice shall also be sent by one of the other methods provided under this section
within 24 hours after initially sent by facsimile transmission) to the following: 
  
 Third Security, LLC 
 Attn: Legal Department 
 The Governor Tyler 
 1881 Grove Ave 
 Radford, VA 24141 
 Fax No.: 540-633-7939 
  
 New River Pharmaceuticals Inc. 
 Attn: Secretary 
 The Governor Tyler 
 1881 Grove Ave 
 Radford, VA 24141 
 Fax No.: 540-633-7939 
  
 or to such other addresses as either party may
designate from time to time in writing. The date of any notice so sent will be deemed to be the date of receipt (or refusal), in the case of United States mail, the following business day, in the case of overnight express mail, and, in the case of
facsimile transmission, upon receipt if received during the recipient’s normal business hours, or at the beginning of the recipient’s next business day if not received during the recipient’s normal business hours. 
  
 10. Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the Commonwealth of Virginia, without giving effect to the principles of conflicts of laws thereof. 
  
 11. Counterparts. This Agreement may be executed in any number of counterparts, each of which when so executed shall be deemed an original but all of which
shall together constitute but one and the same instrument. 
  
 12.
Headings. The headings and captions set forth in this Agreement are for convenience of reference only and shall not affect the construction or interpretation hereof. 
  
 13. Severability. The provisions of this Agreement are severable and should any provisions hereof be void, voidable or
unenforceable under any applicable law, such provision shall not affect or invalidate any other provision of this Agreement, which shall continue to govern the relative rights and duties of the parties as though such void, voidable or unenforceable
provision were not a part hereof. 
  

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 14. Entire Agreement. This Agreement constitutes the entire agreement of the parties with respect to the
subject matter hereof and supersedes all prior and contemporaneous agreements and understandings, oral or written, with respect thereto. This Agreement may not be amended or otherwise modified or supplemented except by a written instrument duly
executed by both parties. No failure or delay by any party in exercising any right, power or privilege hereunder shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the
exercise of any other right, power or privilege. 
  
 IN WITNESS
WHEREOF, the parties hereto have duly executed this Agreement as of the date first above written. 
  

							
	THIRD SECURITY, LLC	 	NEW RIVER PHARMACEUTICALS INC.
				
	By:	 	 /s/ Randal J. Kirk

	 	By:	 	 /s/ Randal J. Kirk


	Name:	 	Randal J. Kirk	 	Name:	 	Randal J. Kirk
	Title:	 	Senior Managing Director	 	Title:	 	Chairman, President and Chief Executive Officer

  
  

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