UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-K/A

(Amendment No. 1)





(Mark One)

|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2012

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from
                     to                     .

Commission file number 000-27436





TITAN PHARMACEUTICALS, INC.

(Exact name of registrant as specified in its charter)







|                                                                   |  |                                        
|------------------------------------------------------------------ |  | ---------------------------------------
|Delaware                                                           |  | 94-3171940                             
|(State or Other Jurisdiction of
Incorporation or Organization)     |  | (I.R.S. Employer Identification Number)
|                                                                   | 
|400 Oyster Point Blvd., Suite 505,
South San Francisco, California |  | 94080                                  
|(Address of principal executive offices)                           |  | (Zip code)                             

Registrants telephone number, including area code: (650) 244-4990





Securities registered pursuant to Section 12(b) of the Act: None

Securities registered pursuant to Section 12(g) of the Act:

Common Stock, $0.001 par value





Indicate by
check mark if the registrant is a well-known seasoned issuer as defined in Rule 405 of the Securities Act.    Yes   ̈    No  x

Indicate by check mark if the registrant is not required to file reports pursuant
to Section 13 or Section 15(d) of the Exchange Act.    Yes   ̈    No  x

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to the filing requirements for the past 90
days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required
to submit and post such files).    x  Yes     ̈  No

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§ 229.405 of this chapter) is
not contained herein, and will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K.  x

Indicate by check mark whether the registrant is a large accelerated filer, an
accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act. (Check
one):



|                        |  |   |  |                           |  |  
|----------------------- |  | - |  | ------------------------- |  | -
|Large accelerated filer |  |  ̈ |  | Accelerated filer         |  | x
|                        |  |   | 
|Non-accelerated filer   |  |  ̈ |  | Smaller Reporting Company |  |  ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act).    Yes   ̈    No  x

The aggregate market value of the 64,592,330 shares of voting and non-voting common equity held by non-affiliates of the registrant based
on the closing price on June 30, 2012 was $45.2 million.

As of March 11, 2013, 81,811,489 shares of common
stock, $.001 par value, of the registrant were issued and outstanding.





DOCUMENTS
INCORPORATED BY REFERENCE:

NONE









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EXPLANATORY NOTE

We are filing this Annual Report on Form 10-K/A for the year ended December 31, 2012 to expand the disclosure under License
Agreements in Item 1 to include the term and termination provisions of our license agreement with Braeburn Pharmaceuticals Sprl. Except as specifically set forth herein, this Annual Report on Form 10-K/A does not reflect any event occurring
subsequent to March 18, 2013, the filing date of the original report.



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PART I

NOTE REGARDING FORWARD-LOOKING STATEMENTS

Statements in this Annual
Report on Form 10-K or in the documents incorporated by reference herein may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of
1934. Reference is made in particular to the description of our plans and objectives for future operations, assumptions underlying such plans and objectives and other forward-looking terminology such as may, expects,
believes, anticipates, intends, expects, projects, or similar terms, variations of such terms or the negative of such terms. Forward-looking statements are based on managements
current expectations. Actual results could differ materially from those currently anticipated due to a number of factors, including but not limited to, uncertainties relating to financing and strategic agreements and relationships; difficulties or
delays in the regulatory approval process; uncertainties relating to sales, marketing and distribution of our drug candidates that may be successfully developed and approved for commercialization; adverse side effects or inadequate therapeutic
efficacy of our drug candidates that could slow or prevent product development or commercialization; dependence on third party suppliers; the uncertainty of protection for our patents and other intellectual property or trade secrets; and
competition.

We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any
forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based.

References herein to we, us, Titan, and our company refer to Titan Pharmaceuticals, Inc.
unless the context otherwise requires.

Probuphine® and ProNeura are trademarks of our company. This Annual Report on Form 10-K also includes trade names and trademarks of companies other than Titan.



|Item 1. | Business
|------- | --------

Overview

We are a biopharmaceutical company developing proprietary therapeutics for the treatment of serious medical disorders. Our product
development programs focus primarily on important pharmaceutical markets with significant unmet medical needs and commercial potential. We are directly developing our product candidates and also utilize corporate, academic and government
partnerships as appropriate. Such collaborations have helped to fund product development and have enabled us to retain significant economic interest in our products.

Our principal asset is Probuphine®, the first slow release implant formulation of buprenorphine, designed to maintain a stable, around the clock blood level of the medicine in patients for six months
following a single treatment. The clinical and manufacturing development of Probuphine for the treatment of opioid dependence in adult patients is complete. The New Drug Application (NDA) seeking approval for treatment of opioid
dependence has been accepted by the United States Food and Drug Administration (FDA) for a Priority Review. Priority Review designation is given to therapies that offer potential major advances in treatment, including improved safety, or
provide a treatment where no adequate therapy exists. Based upon the Prescription Drug User Fee Act (PDUFA), the FDA has set a target date of April 30, 2013 for FDA action on the NDA. An FDA advisory committee review has been
scheduled for March 21, 2013.

Probuphine is inserted subdermally in a patients upper arm providing continuous
medication, and has the potential to enhance patient compliance to treatment, and limit diversion for illicit use and accidental exposure to the daily dosed formulations. The outpatient treatment of opioid addiction with daily dosed sublingual
buprenorphine formulations represents a $1.3 billion market in the U.S., which continues to grow. A transdermal formulation of buprenorphine for the treatment of chronic pain entered the U.S. market in 2011 and Probuphine has the potential to
be developed for treating chronic pain as well.



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In December 2012, we entered into a license agreement with Braeburn
Pharmaceuticals Sprl (Braeburn) that grants Braeburn exclusive commercialization rights to
Probuphine® in the United States and Canada. We received a non-refundable up-front license fee of $15.75 million
and will receive a $50 million milestone payment upon the approval of the NDA by the FDA. Additionally, we will be eligible to receive up to $130 million upon achievement of specified sales milestones and up to $35 million in regulatory milestones
in the event of future NDA submissions and approvals for additional indications, including chronic pain. Titan will receive tiered royalties on net sales of Probuphine ranging from the mid-teens to the low twenties. In addition to the potential
milestone payments, Apple Tree Partners IV, Braeburns parent company, has allocated in excess of $75 million to launch, commercialize and continue the development of Probuphine.

Probuphine is the first product to utilize ProNeura, our novel, proprietary, continuous drug delivery technology. Our ProNeura
technology has the potential to be used in developing products for the treatment of other chronic conditions, such as Parkinsons disease, where maintaining stable, around the clock blood levels of a drug can benefit the patient and improve
medical outcomes.

Under a sublicense agreement with Novartis Pharma AG (Novartis), we are
entitled to royalty revenue of 8-10% of net sales of Fanapt® (iloperidone), an atypical antipsychotic compound
being marketed in the U.S. by Novartis for the treatment of schizophrenia, based on a licensed U.S. patent that expires in October 2016 (excluding the potential of a six month pediatric extension). We have entered into several agreements with
Deerfield Management (Deerfield), a healthcare investment fund, which entitle Deerfield to most of the future royalty revenues related to Fanapt in exchange for cash and debt considerations, the proceeds from which we have been using to
advance the development of Probuphine and for general corporate purposes. We have retained a portion of the royalty revenue from the net sales of Fanapt in excess of specified annual threshold levels; however, based on sales levels to date, it is
unlikely that we will receive any revenue from Fanapt in the next several years, if ever.

We operate in only one business
segment, the development of pharmaceutical products.

Our Products

Probuphine

We are developing Probuphine for the treatment of opioid dependence. Probuphine is the first product specifically designed for the long-term treatment of opioid dependence and it utilizes ProNeura, our
novel, proprietary, long-term drug delivery technology. See Continuous Drug Delivery Technology (ProNeura) below. Probuphine is designed to maintain a stable, around the clock blood level of the drug buprenorphine, an approved agent for
the treatment of opioid dependence. If approved, Probuphine is expected to provide six months of medication following a single treatment. Probuphine has been shown to be effective with an acceptable safety profile in the following Phase 3 clinical
studies:



| |  |  | Two six-month, double-blind, placebo-controlled safety and efficacy trials; one of which included an open label, active control (Suboxone). In both
studies, Probuphine demonstrated superiority to placebo implants, and in the second study, established non-inferiority in comparison to Suboxone;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Two six-month, open-label re-treatment safety trials; and
| | - |  | ---------------------------------------------------------



| |  |  | A pharmacokinetic (relative bioavailability) safety study.
| | - |  | ----------------------------------------------------------

The goal of any therapy for an addictive disorder is to reduce the use of the addictive substance over time and to engage the patient in treatment long enough for therapeutic gains to be consolidated. In
a clinical study, the effectiveness of a treatment for opioid dependence is primarily evaluated by testing a patients urine samples for the presence of illicit opioids over the treatment period. In both placebo-controlled Phase 3 studies of
Probuphine, every participant was required to provide urine samples three times a week, essentially on alternate days. Any missed sample was considered a positive result (i.e. urine testing positive for illicit opioid). In these



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studies, the primary effectiveness of the treatment with Probuphine (i.e. the primary endpoint) was established by comparing the negative urine results (i.e. urine testing negative for illicit
opioid) between the Probuphine and placebo arms using a statistical technique, specifically the cumulative distribution function of negative urines, which basically performs a comparative analysis on the relative proportions of negative
urines between treatment groups over the time period of treatment. The patients in the Probuphine arm showed clinically meaningful and a statistically significant difference in the negative urines as compared to the placebo arm in both studies, i.e.
the Probuphine patients had statistically more negative results than the placebo arm, demonstrating that the treatment with Probuphine was successful in reducing their usage of illicit opioids as compared to the treatment with placebo. These
favorable results for Probuphine were also confirmed by a significant difference over the placebo arm in other secondary measures such as retention in treatment, withdrawal symptoms and craving for opioids, all of which are monitored by clinicians
to see if a treatment is providing clinically meaningful benefit to the patients.

Results for the first double-blind,
placebo-controlled safety and efficacy study have been published in the Journal of the American Medical Association (JAMA, October 2010).

Patients who completed the controlled studies were eligible for enrollment in the six-month re-treatment studies, which provided data on up to one full year of treatment. The pharmacokinetic safety study
has provided important data on the level of buprenorphine in the blood during the treatment period and gives a good profile of the safety of Probuphine. Data from all of these studies was presented at several scientific meetings, including the
International Society of Addiction Medicine Annual Meetings in November 2008 and September 2011, the American Society of Addiction Medicine Annual Meetings in May 2009 and 2012, American Society of Addiction Medicine Education Forum in October 2011,
and the American College of Neuropharmacology in November 2009 and 2012.

These studies are part of a registration directed
program intended to obtain marketing approval of Probuphine for the treatment of opioid dependence in the U.S. and in Europe. We met with the FDA in October 2011 for a pre-NDA meeting and reviewed the clinical development program as well as the
chemistry, manufacturing and controls (CMC) aspects of the NDA. Based on this interaction we completed the requirements for an NDA and submitted it to the FDA in October 2012. The NDA seeking approval for the maintenance treatment of
opioid dependence has been accepted by the FDA for a Priority Review. Priority Review designation is given to therapies that offer potential major advances in treatment, including improved safety, or provide a treatment where no adequate therapy
exists. Based upon the PDUFA requirements, an FDA advisory committee review has been scheduled for March 21, 2013 and the FDA has set a target date of April 30, 2013 for FDA action on the NDA. If approved, Probuphine will be commercialized
in the U.S. and Canada by Braeburn. We will seek appropriate commercial partners for Probuphine in other countries, particularly where therapy with daily dosed buprenorphine is already approved.

Continuous Drug Delivery Technology (ProNeura)

Our continuous drug delivery system consists of a small, solid rod made from a mixture of ethylene-vinyl acetate (EVA) and a drug substance. The resulting product is a solid matrix that is
placed subcutaneously, normally in the upper arm in a simple office procedure, and is removed in a similar manner at the end of the treatment period. The drug substance is released slowly, at continuous levels, through the process of dissolution.
This results in a steady rate of release similar to intravenous administration. We believe that such long-term, linear release characteristics are desirable by avoiding peak and trough level dosing that may pose problems for many disease settings.

Our ProNeura technology was developed to address the need for a simple, practical method to achieve continuous long-term drug
delivery, and potentially can provide steady drug release on an outpatient basis over extended periods of up to 6-12 months. This technology has been validated with the successful development of Probuphine, and its potential commercialization in the
near term is likely to further strengthen the appeal of this



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continuous drug delivery system. We continue to seek opportunities to develop this drug delivery technology for other potential treatment applications in which conventional treatment is limited
by variability in blood drug levels and poor patient compliance (e.g. treatment of Parkinson disease with dopamine agonists). During 2012, with the support of an SBIR grant, we completed a non-clinical study with long-term delivery of dopamine
agonists which supports the potential to develop an implant delivering ropinirole for treating Parkinsons disease. Additional non clinical testing will be required to develop an optimal formulation and evaluating toxicity prior to any clinical
testing. We are also evaluating other drugs and disease settings to establish product development programs during 2013.

Fanapt® (iloperidone)

Fanapt (iloperidone) is an atypical antipsychotic approved by the FDA for the treatment of schizophrenia currently being marketed by
Novartis in the U.S. Under a sublicense agreement with Novartis, we are entitled to a royalty of 8-10% of net sales, based on a U.S. patent that we licensed from Sanofi-Aventis. The U.S. patent expires in October 2016 (excluding a six-month
pediatric extension). Vanda Pharmaceuticals, Inc. (Vanda) owns the development and commercialization rights to the oral and depot formulations of this product for the rest of the world. However, because patent coverage on the compound
has now expired in the significant markets outside of the U.S. and no patent term extensions are possible since the product was not approved in these countries prior to patent expiration, we do not expect any royalties on any future sales in such
markets.

We have entered into several agreements with Deerfield, which entitle Deerfield to most of the future royalty
revenues related to Fanapt in exchange for cash and debt considerations, the proceeds of which have been used to advance the development of Probuphine and for general corporate purposes. We have retained a portion of the royalty revenue from net
sales of Fanapt in excess of specified annual threshold levels; however, based on sales levels to date, it is unlikely that we will receive any revenue from Fanapt in the next several years, if ever. We do not incur any ongoing expenses associated
with this product.

License Agreements

In December 2012, we entered into a license agreement with Braeburn pursuant to which we granted Braeburn an exclusive right and license to commercialize Probuphine in the United States of America and its
territories, including Puerto Rico, and Canada (the Territory). Under the agreement, Braeburn made a non-refundable up-front license fee payment of $15.75 million and agreed to pay us tiered royalties on net sales of Probuphine ranging
from the mid-teens to the low twenties. Additionally, we will receive $50 million upon FDA approval of the NDA for Probuphine and at such time ownership of the NDA will transfer to Braeburn. We are also eligible to receive up to an additional $130
million upon the achievement of specified sales milestones and up to $35 million in regulatory milestones. We will retain all of the rights to Probuphine outside the Territory. Unless earlier terminated, the license agreement will expire on the
later of (i) the 15th anniversary of the date of product launch in the Territory or (ii) the expiration of the last to expire patent in the Territory covered by the agreement (the Term). Either party may terminate the agreement
prior to the expiration of the Term in the event of a material breach by the other party that remains uncured or in the event of the other partys bankruptcy. We may terminate the agreement if, for reasons other than force majeure, regulatory,
safety, manufacturing or product quality issues, Braeburn discontinues commercial sale of the product and fails to resume sales within 30 days following notice or in the event Braeburn or any of its affiliates or sublicensees commences any legal
proceeding seeking to challenge or dispute the validity or ownership of the licensed patents. Braeburn may terminate the agreement in the event that Braeburn, notwithstanding good faith efforts to do so, is unable to enter into an agreement for the
supply of EVA or if such a supply agreement is terminated by Braeburn due to a material breach by the supplier or the supplier fails to provide EVA to Braeburn for a period of at least three months. Braeburn may also terminate the agreement
(i) on a country by country basis upon six months notice following the occurrence of any significant competition in such country, as such term is defined in the agreement; (ii) immediately upon notice if Braeburn
determines in good faith that it is inadvisable to continue commercialization as a result of any actual or perceived safety issues. In addition, pursuant to the terms of an amendment to the license agreement entered into in May 2013, Braeburn the
right to terminate the Agreement in



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the event that (A) after May 28, 2013, based on written or oral communications from or with the FDA, Braeburn reasonably determines either that the FDA will require significant development
to be performed before approval of the Probuphine New Drug Application (NDA) can be given, such
as, but not limited to, one or more additional controlled clinical studies with a clinical efficacy endpoint, or substantial post-approval commitments that may materially impact the products financial returns or that the FDA will require one or more
changes in the proposed label, which change(s) Braeburn reasonably determines will materially reduce the authorized prescribed patient base, or (B) the NDA has not been approved by the FDA on or before June 30, 2014.

In January 1997, we acquired an exclusive worldwide license under U.S. and foreign patents and patent applications relating to the use of
iloperidone for the treatment of psychiatric and psychotic disorders and analgesia from Sanofi-Aventis SA (Sanofi-Aventis) (formerly Hoechst Marion Roussel, Inc.). The Sanofi-Aventis agreement provides for the payment of royalties on
future net sales and requires us to satisfy certain other terms and conditions, specifically continued diligent product development and commercialization efforts standard for these types of agreements, in order to retain our rights. In November
1997, we granted a worldwide sublicense, exclusive of Japan, to Novartis under which Novartis continued, at its expense, all further development of iloperidone. In April 2001, that sublicense was extended to include Japan. Under this agreement,
Novartis agreed to pay Titan a royalty on future net sales of the product equal to 8% of annual worldwide net sales up to $200 million and 10% of annual worldwide net sales above $200 million, in addition to royalty payments owed by us to
Sanofi-Aventis. In June 2004, Novartis granted Vanda the worldwide rights to develop and commercialize iloperidone. In October 2009, Vanda and Novartis amended and restated their sub-license agreement whereby Novartis acquired the U.S. and Canadian
rights to commercialize Fanapt, the oral formulation of iloperidone approved in the U.S. Novartis also acquired the U.S. and Canadian development and commercialization rights to the depot formulation previously under development by Vanda and
retained the right of first negotiation to co-market Fanapt and the depot formulation in the rest of the world. All of our rights and economic interests in iloperidone, including royalties on sales, remained essentially unchanged under these
agreements and, as previously stated, we have entered into several agreements with Deerfield, which entitle Deerfield to the future royalty revenues related to Fanapt in exchange for cash and debt considerations.

In October 1995, we acquired from the Massachusetts Institute of Technology (MIT) an exclusive worldwide license to certain
U.S. and foreign patents relating to our continuous drug delivery system that provided for the payment of certain royalties and other payments with respect to based the licensed technology. Because the patent terms have expired, this license was
terminated on July 31, 2012 and we have no continuing obligations to MIT with respect to our ProNeura technology.

In
July 2005, we entered into an agreement with the University of Iowa Research Foundation. Under this agreement, we received an exclusive worldwide license to patent rights held by the University of Iowa Research Foundation covering the methods of
treating biofilm formation, pseudomonas aeruginosa growth, human deficiency virus, and intracellular pathogens and pathogens causing chronic pulmonary infection using gallium maltolate. Under this agreement, we are required to pay a license issuance
fee and certain minimum annual royalty payments. In addition, we are required to pay royalties based on net sales of products and processes incorporating the licensed technology. We will evaluate the utility of this license with respect to future
product development programs and take action as appropriate.

Patents and Proprietary Rights

Four patent applications have been filed which incorporate the use of specific compounds with the continuous delivery technology,
including two applications related to Probuphine for the potential treatment of opioid addiction and chronic pain. In June 2010, the United States Patent and Trademark Office (USPTO) issued a patent covering Probuphine for the treatment
of opiate addiction. Titan is the owner of this patent which claims a method for treating opiate addiction with a subcutaneously implanted device comprising buprenorphine and EVA, a biocompatible copolymer that releases buprenorphine continuously
for extended periods of time. This patent will expire in April 2024. Patents have issued in Australia, India, Japan, Mexico and New Zealand. Further prosecution of these applications is currently proceeding at the USPTO and corresponding agencies in



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Europe, Canada, India and Hong Kong. Patents covering certain dopamine agonist implants have already been issued or allowed in Europe, Japan, Australia, Canada, South Korea, Mexico, New Zealand,
South Africa, and Hong Kong, while prosecution of the patent application continues in the U.S., Israel, India and China.

We
hold a license from Sanofi-Aventis under certain issued U.S. patents and certain issued foreign patents relating to iloperidone and its methods of use in the treatment of psychiatric disorders, psychotic disorders and analgesia. The term of the U.S.
patent that covers certain aspects of our iloperidone product expires in October 2016, excluding a six month extension possible if an approval of pediatric indication is obtained. Limited foreign patent protection remains in Lichtenstein, Georgia,
Korea and the Philippines, although no royalty payments are expected from these patents.

We are the licensee from the
University of Iowa Research Foundation (UIRF) of two issued U.S. patents (expiring in 2016) relating to methods of use of gallium compounds to inhibit the growth of P. aeruginosa, and the treatment of infections by pathogens causing
chronic pulmonary infection. We are also the licensee from UIRF of certain rights to patent applications covering the use of gallium complexes in preventing and also treating bacterial biofilm-based infections, for which patents have issued in
Australia, Japan, Mexico, New Zealand, and South Africa, and prosecution in the U.S., Canada, Europe, China, Hong Kong, and India continues.

Competition

The
pharmaceutical and biotechnology industries are characterized by rapidly evolving technology and intense competition. Many companies of all sizes, including major pharmaceutical companies and specialized biotechnology companies, are engaged in the
development and commercialization of therapeutic agents designed for the treatment of the same diseases and disorders that we target. Many of our competitors have substantially greater financial and other resources, larger research and development
staff and more experience in the regulatory approval process. Moreover, potential competitors have or may have patents or other rights that conflict with patents covering our technologies. For risks we face with respect to competition, see
Risk FactorsWe face intense competition.

With respect to Probuphine,
Reckitt Benckiser Group, PLC (Reckitt) markets globally a sublingual buprenorphine product (tablet and film formulations) for the treatment of opioid dependence. This product
(Subutex®, Suboxone®) which is administered daily, will compete with our six-month implantable product for treating opioid dependence. Reckitt recently announced the discontinuation of
the sublingual tablet formulation of Suboxone in favor of the sublingual film formulation which they will continue to market aggressively. In addition, in February 2013, two generic sublingual tablet formulations of Suboxone were approved by the FDA
which are expected to compete with Suboxone. Other forms of buprenorphine are also in development by other companies, including intramuscular injections, buccal delivery and intranasally delivered buprenorphine, which also might compete with our
product. In 2010, Alkermes, Inc. received FDA approval to market Vivitrol®, a one month depot injection of
naltrexone as a maintenance treatment for opioid dependent patients who have successfully achieved abstinence. We are aware of one month depot formulations of buprenorphine in early clinical development for the treatment of opioid dependence, but we
are not aware of any six-month formulations being developed other than Probuphine.

Manufacturing

The manufacturing of Probuphine has primarily been conducted at DPT Laboratories, Inc., and we have expanded the manufacturing facility at
this contract manufacturer to establish commercial scale capability to support the potential market launch of Probuphine, and ongoing demand following potential approval by the FDA.



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Government Regulation

FDA Approval Process

In
the United States, pharmaceutical products are subject to extensive regulation by the FDA. The Federal Food, Drug, and Cosmetic Act, or the FDC Act, and other federal and state statutes and regulations, govern, among other things, the research,
development, testing, manufacture, storage, recordkeeping, approval, labeling, promotion and marketing, distribution, post-approval monitoring and reporting, sampling, and import and export of pharmaceutical products. Failure to comply with
applicable U.S. requirements may subject a company to a variety of administrative or judicial sanctions, such as FDA refusal to approve pending new drug applications, or NDAs, warning letters, product recalls, product seizures, total or partial
suspension of production or distribution, injunctions, fines, civil penalties, and criminal prosecution.

Pharmaceutical
product development in the U.S. typically involves preclinical laboratory and animal tests, the submission to the FDA of either a notice of claimed investigational exemption or an investigational new drug application, or IND, which must become
effective before clinical testing may commence, and adequate and well-controlled clinical trials to establish the safety and effectiveness of the drug for each indication for which FDA approval is sought. Satisfaction of FDA pre-market approval
requirements typically takes many years and the actual time required may vary substantially based upon the type, complexity, and novelty of the product or disease.

Preclinical tests include laboratory evaluation of product chemistry, formulation, and toxicity, as well as animal trials to assess the characteristics and potential safety and efficacy of the product.
The conduct of the preclinical tests must comply with federal regulations and requirements, including good laboratory practices. The results of preclinical testing are submitted to the FDA as part of an IND along with other information, including
information about product chemistry, manufacturing and controls, and a proposed clinical trial protocol. Long term preclinical tests, such as animal tests of reproductive toxicity and carcinogenicity, may continue after the IND is submitted.

Clinical trials involve the administration of the investigational new drug to healthy volunteers or patients under the
supervision of a qualified investigator. Clinical trials must be conducted: (i) in compliance with federal regulations; (ii) in compliance with good clinical practice, or GCP, an international standard meant to protect the rights and
health of patients and to define the roles of clinical trial sponsors, administrators, and monitors; as well as (iii) under protocols detailing the objectives of the trial, the parameters to be used in monitoring safety, and the effectiveness
criteria to be evaluated. Each protocol involving testing on U.S. patients and subsequent protocol amendments must be submitted to the FDA as part of the IND.

The FDA may order the temporary, or permanent, discontinuation of a clinical trial at any time, or impose other sanctions if it believes that the clinical trial either is not being conducted in accordance
with FDA requirements or presents an unacceptable risk to the clinical trial patients. The study protocol and informed consent information for patients in clinical trials must also be submitted to an institutional review board, or IRB, for approval.
An IRB may also require the clinical trial at the site to be halted, either temporarily or permanently, for failure to comply with the IRBs requirements, or may impose other conditions.

Clinical trials to support NDAs for marketing approval are typically conducted in three sequential phases, but the phases may overlap. In
Phase 1, the initial introduction of the drug into healthy human subjects or patients, the drug is tested to assess metabolism, pharmacokinetics, pharmacological actions, side effects associated with increasing doses, and, if possible, early
evidence on effectiveness. Phase 2 usually involves trials in a limited patient population to determine the effectiveness of the drug for a particular indication, dosage tolerance, and optimum dosage, and to identify common adverse effects and
safety risks. If a compound demonstrates evidence of effectiveness and an acceptable safety profile in Phase 2 evaluations, Phase 3 trials are undertaken to obtain the additional information about clinical efficacy and safety in a larger number of
patients, typically at geographically dispersed clinical trial sites, to permit FDA to evaluate the overall benefit-risk relationship of the drug and to provide adequate information for the labeling of the drug.



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After completion of the required clinical testing, an NDA is prepared and submitted to the
FDA. FDA approval of the NDA is required before marketing of the product may begin in the U.S. The NDA must include the results of all preclinical, clinical, and other testing and a compilation of data relating to the products pharmacology,
chemistry, manufacture, and controls. The cost of preparing and submitting an NDA is substantial.

Once the submission is
accepted for filing, the FDA begins an in-depth review. Priority review can be applied to drugs that the FDA determines offer major advances in treatment, or provide a treatment where no adequate therapy exists. The FDA may refer applications for
novel drug products, or drug products which present difficult questions of safety or efficacy, to an advisory committee  typically a panel that includes clinicians and other experts  for review, evaluation, and a recommendation as to
whether the application should be approved. The FDA is not bound by the recommendation of an advisory committee, but it generally follows such recommendations. Before approving an NDA, the FDA will typically inspect one, or more, clinical sites to
assure compliance with GCP. Additionally, the FDA will inspect the facility or the facilities at which the drug is manufactured. FDA will not approve the product unless compliance with current good manufacturing practice, or GMP  a quality
system regulating manufacturing  is satisfactory and the NDA contains data that provide substantial evidence that the drug is safe and effective in the indication studied.

After the FDA evaluates the NDA and the manufacturing facilities, it issues either an approval letter or a complete response letter. A
complete response letter generally outlines the deficiencies in the submission and may require substantial additional testing, or information, in order for the FDA to reconsider the application. If, or when, those deficiencies have been addressed to
the FDAs satisfaction in a resubmission of the NDA, the FDA will issue an approval letter.

An approval letter
authorizes commercial marketing of the drug with specific prescribing information for specific indications. As a condition of NDA approval, the FDA may require a risk evaluation and mitigation strategy, or REMS, to help ensure that the benefits of
the drug outweigh the potential risks. REMS can include medication guides, communication plans for healthcare professionals, and elements to assure safe use, or ETASU. ETASU can include, but are not limited to, special training or certification for
prescribing or dispensing, dispensing only under certain circumstances, special monitoring, and the use of patient registries. The requirement for a REMS can materially affect the potential market and profitability of the drug. Moreover, product
approval may require substantial post-approval testing and surveillance to monitor the drugs safety or efficacy. Once granted, product approvals may be withdrawn if compliance with regulatory standards is not maintained or problems are
identified following initial marketing.

The Hatch-Waxman Act

In seeking approval for a drug through an NDA, applicants are required to list with the FDA each patent whose claims
cover the applicants product. Upon approval of a drug, each of the patents listed in the application for the drug is then published in the FDAs Approved Drug Products with Therapeutic Equivalence Evaluations, commonly known as the Orange
Book. Drugs listed in the Orange Book can, in turn, be cited by potential competitors in support of approval of an abbreviated new drug application, or ANDA. An ANDA provides for marketing of a drug product that has the same active ingredients in
the same strengths and dosage form as the listed drug and has been shown through bioequivalence testing to be therapeutically equivalent to the listed drug. Other than the requirement for bioequivalence testing, ANDA applicants are not required to
conduct, or submit results of, pre-clinical or clinical tests to prove the safety or effectiveness of their drug product. Drugs approved in this way are commonly referred to as generic equivalents to the listed drug, and can often be
substituted by pharmacists under prescriptions written for the original listed drug.

The ANDA applicant is required to
certify to the FDA concerning any patents listed for the approved product in the FDAs Orange Book. Specifically, the applicant must certify that: (i) the required patent information has not been filed; (ii) the listed patent has
expired; (iii) the listed patent has not expired, but will expire on a particular date and approval is sought after patent expiration; or (iv) the listed patent is invalid or will



10



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not be infringed by the new product. A certification that the new product will not infringe the already approved products listed patents, or that such patents are invalid, is called a
Paragraph IV certification. If the applicant does not challenge the listed patents, the ANDA application will not be approved until all the listed patents claiming the referenced product have expired. The ANDA application also will not be approved
until any non-patent exclusivity listed in the Orange Book for the referenced product has expired. Federal law provides a period of five years following approval of a drug containing no previously approved active ingredients during which ANDAs for
generic versions of those drugs cannot be submitted, unless the submission contains a Paragraph IV challenge to a listed patent - in which case the submission may be made four years following the original product approval. Federal law provides for a
period of three years of exclusivity during which the FDA cannot grant effective approval of an ANDA based on the approval of a listed drug that contains previously approved active ingredients but is approved in a new dosage form, route of
administration or combination, or for a new use; the approval of which was required to be supported by new clinical trials conducted by, or for, the applicant.

Section 505(b)(2) New Drug Applications

Most drug products
obtain FDA marketing approval pursuant to an NDA or an ANDA. A third alternative is a special type of NDA, commonly referred to as a Section 505(b)(2) NDA, enables the applicant to rely, in part, on the FDAs previous approval of a similar
product, or published literature, in support of its application. Section 505(b)(2) permits the filing of an NDA where at least some of the information required for approval comes from studies not conducted by, or for, the applicant and for
which the applicant has not obtained a right of reference. If the 505(b)(2) applicant can establish that reliance on the FDAs previous approval is scientifically appropriate, it may eliminate the need to conduct certain preclinical or clinical
studies of the new product. The FDA may also require companies to perform additional studies or measurements to support the change from the approved product. The FDA may then approve the new product candidate for all, or some, of the label
indications for which the referenced product has been approved, as well as for any new indication sought by the Section 505(b)(2) applicant.

Advertising and Promotion

Once an NDA is approved, a product will
be subject to certain post-approval requirements. For instance, the FDA closely regulates the post-approval marketing and promotion of drugs, including standards and regulations for direct-to-consumer advertising, off-label promotion,
industry-sponsored scientific and educational activities and promotional activities involving the internet.

Drugs may be
marketed only for the approved indications and in accordance with the provisions of the approved labeling. Changes to some of the conditions established in an approved application, including changes in indications, labeling, or manufacturing
processes or facilities, require submission and FDA approval of a new NDA or NDA supplement before the change can be implemented. An NDA supplement for a new indication typically requires clinical data similar to that in the original application,
and the FDA uses the same procedures and actions in reviewing NDA supplements as it does in reviewing NDAs.

Adverse
Event Reporting and GMP Compliance

Adverse event reporting and submission of periodic reports is required following
FDA approval of an NDA. The FDA also may require post-marketing testing, known as Phase 4 testing, risk minimization action plans, and surveillance to monitor the effects of an approved product, or the FDA may place conditions on an approval that
could restrict the distribution or use of the product. In addition, quality-control, drug manufacture, packaging, and labeling procedures must continue to conform to current good manufacturing practices, or cGMPs, after approval. Drug manufacturers
and certain of their subcontractors are required to register their establishments with FDA and certain state agencies. Registration with the FDA subjects entities to periodic unannounced inspections by the FDA, during which the agency inspects
manufacturing facilities to assess compliance with cGMPs. Accordingly, manufacturers must continue to expend time, money, and effort in the areas of production and quality-control to maintain compliance with cGMPs. Regulatory authorities may
withdraw product approvals



11



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or request product recalls if a company fails to comply with regulatory standards, if it encounters problems following initial marketing, or if previously unrecognized problems are subsequently
discovered.

Pediatric Information

Under the Pediatric Research Equity Act, or PREA, NDAs or supplements to NDAs must contain data to assess the safety and effectiveness of the drug for the claimed indications in all relevant pediatric
subpopulations and to support dosing and administration for each pediatric subpopulation for which the drug is safe and effective. The FDA may grant full or partial waivers, or deferrals, for submission of data. Unless otherwise required by
regulation, PREA does not apply to any drug for an indication for which orphan designation has been granted.

The Best
Pharmaceuticals for Children Act, or BPCA, provides NDA holders a six-month extension of any exclusivity  patent or non-patent  for a drug if certain conditions are met. Conditions for exclusivity include the FDAs determination
that information relating to the use of a new drug in the pediatric population may produce health benefits in that population, the FDA making a written request for pediatric studies, and the applicant agreeing to perform, and reporting on, the
requested studies within the statutory timeframe. Applications under the BPCA are treated as priority applications, with all of the benefits that designation confers.

Physician Drug Samples

As part of the sales and marketing process,
pharmaceutical companies frequently provide samples of approved drugs to physicians. The Prescription Drug Marketing Act, or the PDMA, imposes requirements and limitations upon the provision of drug samples to physicians, as well as prohibits states
from licensing distributors of prescription drugs unless the state licensing program meets certain federal guidelines that include minimum standards for storage, handling, and record keeping. In addition, the PDMA sets forth civil and criminal
penalties for violations.

Controlled Substances

Manufacturers of controlled substances, including buprenorphine, are also subject to the licensing, quota, and regulatory requirements of
the Controlled Substances Act. Failure to comply with the Controlled Substances Act and the regulations promulgated thereunder could subject companies to loss or suspension of those licenses and to civil or criminal penalties.

Anti-Kickback, False Claims Laws & The Prescription Drug Marketing Act

In addition to FDA restrictions on marketing of pharmaceutical products, several other types of state and federal laws have been applied
to restrict certain marketing practices in the pharmaceutical industry in recent years. These laws include anti-kickback statutes and false claims statutes. The federal healthcare program anti-kickback statute prohibits, among other things,
knowingly and willfully offering, paying, soliciting or receiving remuneration to induce; or in return for; purchasing, leasing, ordering or arranging for the purchase, lease or order of any healthcare item or service reimbursable under Medicare,
Medicaid, or other federally financed healthcare programs. This statute has been interpreted to apply to arrangements between pharmaceutical manufacturers on the one hand and prescribers, purchasers, and formulary managers on the other. Violations
of the anti-kickback statute are punishable by imprisonment, criminal fines, civil monetary penalties, and exclusion from participation in federal healthcare programs. Although there are a number of statutory exemptions and regulatory safe harbors
protecting certain common activities from prosecution or other regulatory sanctions, the exemptions and safe harbors are drawn narrowly, and practices that involve remuneration intended to induce prescribing, purchases, or recommendations may be
subject to scrutiny if they do not qualify for an exemption or safe harbor.

Federal false claims laws prohibit any person
from knowingly presenting, or causing to be presented, a false claim for payment to the federal government, or knowingly making, or causing to be made, a false statement to have



12



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a false claim paid. Recently, several pharmaceutical and other healthcare companies have been prosecuted under these laws for allegedly inflating drug prices they report to pricing services,
which in turn were used by the government to set Medicare and Medicaid reimbursement rates, and for allegedly providing free product to customers with the expectation that the customers would bill federal programs for the product. In addition,
certain marketing practices, including off-label promotion, may also violate false claims laws. The majority of states also have statutes or regulations similar to the federal anti-kickback law and false claims laws, which apply to items and
services reimbursed under Medicaid and other state programs, or, in several states, apply regardless of the payor.

Foreign Regulatory
Issues

Sales of pharmaceutical products outside the United States are subject to foreign regulatory requirements that vary
widely from country to country. Whether or not FDA approval has been obtained, approval of a product by a comparable regulatory authority of a foreign country must generally be obtained prior to the commencement of marketing in that country.
Although the time required to obtain such approval may be longer or shorter than that required for FDA approval, the requirements for FDA approval are among the most detailed in the world and FDA approval generally takes longer than foreign
regulatory approvals.

Employees

At December 31, 2012, we had 13 full-time employees, 2 part-time employees and several consultants.



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|Item 1A. | Risk Factors
|-------- | ------------

FDA
approval of Probuphine may be delayed.

At December 31, 2012, we had cash of approximately $18.1 million, which,
together with the FDAs reimbursement of the $2.0 million NDA filing fee, we believe is sufficient to fund our current operations through June 2014. In the event that the FDA issues a complete response letter requiring additional clinical and
manufacturing development prior to approval that would require expenditures in excess of certain amounts specified in our agreement with Braeburn, Braeburn will have the right to either terminate the agreement or, in the event the FDA ultimately
approves Probuphine for sale in the U.S., reduce the amount of the $50 million milestone payment payable to us by the amount of our obligations for the additional development expenses.

If Braeburn were to terminate the agreement, we would not have sufficient funds available to us to complete the FDA approval process and
commercialize Probuphine and, as a result, our business and prospects would be materially adversely impacted. Furthermore, continuation of our current Parkinsons disease development program and the initiation of any additional programs will
depend upon our receipt of the $50 million milestone payment and if such payment is not received or is significantly reduced our ability to fund any new product development programs will be materially impaired.

FDA approval of Probuphine may be denied.

The FDA has targeted April 30, 2013 for FDA action on the Probuphine NDA that we submitted in October 2012. The FDA may deny approval of Probuphine for many reasons, including:



| |  |  | we may be unable to demonstrate to the satisfaction of the FDA that Probuphine is safe and effective for the treatment of opioid dependence in adults;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDA may disagree with our interpretation of data from non-clinical studies or clinical trials;
| | - |  | --------------------------------------------------------------------------------------------------



| |  |  | we may be unable to demonstrate that Probuphines clinical and other benefits outweigh any safety or other perceived risks; or
| | - |  | ------------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDA may fail to approve the manufacturing processes or facilities of the third-party manufacturers with which we have contracted.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------

If Probuphine fails to receive FDA approval, our business and prospects will be materially adversely
impacted.

The timing and amount of revenues from Probuphine, if any, will be wholly dependent on the efforts of third
parties.

We have granted an exclusive license to Braeburn for the commercialization of Probuphine in the United States
and Canada. If approved by the FDA, Braeburn will be solely responsible for the marketing, manufacture and commercialization of Probuphine in the Territory and, accordingly, the timing and amount of any royalty revenues or sales milestones we
receive from this product will be wholly dependent upon Braeburns ability to successfully launch and commercialize this product in the Territory. Braeburn is a recently formed company and does not have a track record upon which investors can
rely on making an investment decision. Additionaly, our ability to generate revenues in the Territory from any additional indications for Probuphine, including chronic pain, depends on Braeburns ability to successfully develop, obtain
regulatory approvals for and commercialize the product for additional indications. We do not have control over the amount and timing of resources that Braeburn will dedicate to these efforts, none of which have commenced to date. We will be
similarly dependent on the development, regulatory and marketing efforts of third parties with respect to revenues, if any, from sales of Probuphine outside the Territory. To date, we have not entered into any collaborative arrangements or granted
any rights with respect to Probuphine in the rest of the world.



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If Probuphine or any other product candidate that we may successfully develop does not
achieve broad market acceptance among physicians, patients, healthcare payors and the medical community, the revenues that it generates from their sales will be limited.

Even if Probuphine or any other product candidate we may in the future develop receives regulatory approval, they may not gain market
acceptance among physicians, patients, healthcare payors and the medical community. Coverage and reimbursement of our product candidates by third-party payors, including government payors, generally is also necessary for commercial success. The
degree of market acceptance of any approved products will depend on a number of factors, including:



| |  |  | the efficacy and safety as demonstrated in clinical trials;
| | - |  | -----------------------------------------------------------



| |  |  | the clinical indications for which the product is approved;
| | - |  | -----------------------------------------------------------



| |  |  | acceptance by physicians, operators of hospitals and clinics and patients of the product as a safe and effective product;
| | - |  | -------------------------------------------------------------------------------------------------------------------------



| |  |  | the potential and perceived advantages of the product over alternative treatments;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | the safety of the product in broader patient groups, including its use outside of approved indications;
| | - |  | -------------------------------------------------------------------------------------------------------



| |  |  | the cost of treatment in relation to alternative treatments;
| | - |  | ------------------------------------------------------------



| |  |  | the availability of adequate reimbursement and pricing by third parties and government authorities;
| | - |  | ---------------------------------------------------------------------------------------------------



| |  |  | the prevalence and severity of adverse events;
| | - |  | ----------------------------------------------



| |  |  | the effectiveness of sales and marketing efforts; and
| | - |  | -----------------------------------------------------



| |  |  | unfavorable publicity relating to the product.
| | - |  | ----------------------------------------------

If any product candidate is approved but does not achieve an adequate level of acceptance by physicians, hospitals and clinics, healthcare payors and patients, we may not generate significant revenue from
such products.

We must comply with extensive government regulations.

The research, development, manufacture labeling, storage, record-keeping, advertising, promotion, import, export, marketing and
distribution of pharmaceutical products are subject to an extensive regulatory approval process by the FDA in the U.S. and comparable health authorities in foreign markets. The process of obtaining required regulatory approvals for drugs is lengthy,
expensive and uncertain. Approval policies or regulations may change and the FDA and foreign authorities have substantial discretion in the pharmaceutical approval process, including the ability to delay, limit or deny approval of a product
candidate for many reasons. Despite the time and expense invested in clinical development of product candidates, regulatory approval is never guaranteed. Regulatory approval may entail limitations on the indicated usage of a drug, which may reduce
the drugs market potential. Even if regulatory clearance is obtained, post-market evaluation of the products, if required, could result in restrictions on a products marketing or withdrawal of the product from the market, as well as
possible civil and criminal sanctions. Of the large number of drugs in development, only a small percentage successfully complete the regulatory approval process and are commercialized.

We are dependent upon key collaborative relationships and license agreements.

We will rely significantly on the resources of third parties to market and commercialize Probuphine, if approved, as well as any other
products we may develop. For example, our ability to ultimately derive revenues from Probuphine in the Territory is dependent upon Braeburn implementing a successful marketing program for the treatment of opioid dependence in adults and pursuing
development and commercialization of the product for other indications. Beyond any contractual rights, we cannot control the amount or timing of resources that any



15



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existing or future corporate partner devotes to product development and commercialization efforts for our product candidates. We depend on our ability to maintain existing collaborative
relationships, to develop new collaborative relationships with third parties and potentially to acquire or in-license additional products and technologies for the development of new product candidates.

Our dependence on third party collaborators and license agreements subjects us to a number of risks, including:



| |  |  | our collaborators may not comply with applicable regulatory guidelines with respect to developing or commercializing our products, which could
adversely impact sales or future development of our products;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we and our collaborators could disagree as to future development plans and our collaborators may delay, fail to commence or stop future clinical trials
or other development; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | there may be disputes between us and our collaborators, including disagreements regarding the license agreements, that may result in the delay of or
failure to achieve developmental, regulatory and commercial objectives that would result in milestone or royalty payments and/or the delay or termination of any future development or commercialization of our products.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In addition, collaborators may, to the extent permitted by our agreements, develop products that divert resources from our products,
preclude us from entering into collaborations with their competitors or terminate their agreements with us prematurely. Moreover, disagreements could arise with our collaborators or strategic partners over rights to our intellectual property and our
rights to share in any of the future revenues from products or technologies resulting from use of our technologies, or our activities in separate fields may conflict with other business plans of our collaborators.

We face risks associated with third parties conducting preclinical studies and clinical trials of our products; as well as our
dependence on third parties to manufacture any products that we may successfully develop.

We depend on third-party
laboratories and medical institutions to conduct preclinical studies and clinical trials for our products and other third-party organizations to perform data collection and analysis, all of which must maintain both good laboratory and good clinical
practices. We also depend upon third party manufacturers for the production of any products we may successfully develop to comply with current Good Manufacturing Practices of the FDA, which are similarly outside our direct control. If third party
laboratories and medical institutions conducting studies of our products fail to maintain both good laboratory and clinical practices, the studies could be delayed or have to be repeated. Similarly, if the manufacturers of any products we develop in
the future fail to comply with current Good Manufacturing Practices of the FDA, we may be forced to cease manufacturing such product until we have found another third party to manufacture the product.

We face risks associated with product liability lawsuits that could be brought against us.

Our liability insurance coverage may not be sufficient to cover claims that may be made against us in the event that the use or misuse of
our product candidates causes, or merely appears to have caused, personal injury or death. Any claims against us, regardless of their merit, could severely harm our financial condition, strain our management and other resources or destroy the
prospects for commercialization of the product which is the subject of any such claim.

We may be unable to protect our
patents and proprietary rights.

Our future success will depend to a significant extent on our ability to:



| |  |  | obtain and keep patent protection for our products and technologies on an international basis;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | enforce our patents to prevent others from using our inventions;
| | - |  | ----------------------------------------------------------------



16



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| |  |  | maintain and prevent others from using our trade secrets; and
| | - |  | -------------------------------------------------------------



| |  |  | operate and commercialize products without infringing on the patents or proprietary rights of others.
| | - |  | -----------------------------------------------------------------------------------------------------

We cannot assure you that our patent rights will afford any competitive advantages, and these rights may be challenged or circumvented by
third parties. Further, patents may not be issued on any of our pending patent applications in the U.S. or abroad. Because of the extensive time required for development, testing and regulatory review of a potential product, it is possible that
before a potential product can be commercialized, any related patent may expire or remain in existence for only a short period following commercialization, reducing or eliminating any advantage of the patent. If we sue others for infringing our
patents, a court may determine that such patents are invalid or unenforceable. Even if the validity of our patent rights is upheld by a court, a court may not prevent the alleged infringement of our patent rights on the grounds that such activity is
not covered by our patent claims.

In addition, third parties may sue us for infringing their patents. In the event of a
successful claim of infringement against us, we may be required to:



| |  |  | pay substantial damages;
| | - |  | ------------------------



| |  |  | stop using our technologies and methods;
| | - |  | ----------------------------------------



| |  |  | stop certain research and development efforts;
| | - |  | ----------------------------------------------



| |  |  | develop non-infringing products or methods; and
| | - |  | -----------------------------------------------



| |  |  | obtain one or more licenses from third parties.
| | - |  | -----------------------------------------------

If required, we cannot assure you that we will be able to obtain such licenses on acceptable terms, or at all. If we are sued for infringement, we could encounter substantial delays in development,
manufacture and commercialization of our product candidates. Any litigation, whether to enforce our patent rights or to defend against allegations that we infringe third party rights, will be costly, time consuming, and may distract management from
other important tasks.

We also rely in our business on trade secrets, know-how and other proprietary information. We seek to
protect this information, in part, through the use of confidentiality agreements with employees, consultants, advisors and others. Nonetheless, we cannot assure you that those agreements will provide adequate protection for our trade secrets,
know-how or other proprietary information and prevent their unauthorized use or disclosure. To the extent that consultants, key employees or other third parties apply technological information independently developed by them or by others to our
proposed products, disputes may arise as to the proprietary rights to such information, which may not be resolved in our favor.

We face intense competition.

Competition in the pharmaceutical and biotechnology industries is intense. We face, and will continue to face, competition from numerous companies that currently market, or are developing, products for
the treatment of the diseases and disorders we have targeted. Many of these entities have significantly greater research and development capabilities, experience in obtaining regulatory approvals and manufacturing, marketing, financial and
managerial resources than we have. We also compete with universities and other research institutions in the development of products, technologies and processes, as well as the recruitment of highly qualified personnel. Our competitors may succeed in
developing technologies or products that are more effective than the ones we have under development or that render our proposed products or technologies noncompetitive or obsolete. In addition, our competitors may achieve product commercialization
or patent protection earlier than we will.

Healthcare reform and restrictions on reimbursements may limit our financial
returns.

Braeburns ability to commercialize Probuphine in the Territory and our ability or the ability of any
future collaborators to commercialize Probuphine outside the Territory or to commercialize any other products we may



17



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successfully develop will depend in part on the extent to which government health administration authorities, private health insurers and other organizations will reimburse consumers for the cost
of these products. These third parties are increasingly challenging both the need for and the price of new drug products. Significant uncertainty exists as to the reimbursement status of newly approved therapeutics. Adequate third party
reimbursement may not be available for our own or our collaborators drug products to enable us or them to maintain price levels sufficient to realize an appropriate return on their and our investments in research and product development.

We may not be able to retain our key management and scientific personnel.

As a company with a limited number of personnel, we are highly dependent on the services of our executive management and scientific staff,
in particular Sunil Bhonsle and Marc Rubin, our President and Executive Chairman, respectively, and our Executive Vice President and Chief Development Officer, all of whom are parties to employment agreements with us. The loss of one or more of such
individuals could substantially impair ongoing research and development programs and could hinder our ability to obtain corporate partners. Our success depends in large part upon our ability to attract and retain highly qualified personnel. We
compete in our hiring efforts with other pharmaceutical and biotechnology companies, as well as universities and nonprofit research organizations, and we may not be successful in our efforts to attract and retain personnel.

Our stock price has been and will likely continue to be volatile.

Our stock price has experienced substantial fluctuations and could continue to fluctuate significantly due to a number of factors,
including:



| |  |  | variations in our anticipated or actual operating results or prospects;
| | - |  | -----------------------------------------------------------------------



| |  |  | sales of substantial amounts of our common stock;
| | - |  | -------------------------------------------------



| |  |  | announcements about us or about our competitors, including introductions of new products;
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | litigation and other developments relating to our patents or other proprietary rights or those of our competitors;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | conditions in the pharmaceutical or biotechnology industries;
| | - |  | -------------------------------------------------------------



| |  |  | governmental regulation and legislation; and
| | - |  | --------------------------------------------



| |  |  | change in securities analysts estimates of our performance, or our failure to meet analysts expectations.
| | - |  | -----------------------------------------------------------------------------------------------------------

Our common stock is deemed to be a penny stock, which may make it more difficult for investors to sell their shares due
to suitability requirements.

Our common stock is subject to Rule 15g-1 through 15g-9 under the Securities Exchange Act
of 1934, as amended (the Exchange Act), which imposes certain sales practice requirements on broker-dealers which sell our common stock to persons other than established customers and accredited investors (generally,
individuals with a net worth in excess of $1,000,000 or annual incomes exceeding $200,000 (or $300,000 together with their spouses)). For transactions covered by this rule, a broker-dealer must make a special suitability determination for the
purchaser and have received the purchasers written consent to the transaction prior to the sale. This rule adversely affects the ability of broker-dealers to sell our common stock and the ability of our stockholders to sell their shares of
common stock.

Additionally, our common stock is subject to the SEC regulations for penny stock. Penny stock
includes any equity security that is not listed on a national exchange and has a market price of less than $5.00 per share, subject to certain exceptions. The regulations require that prior to any non-exempt buy/sell transaction in a penny stock, a
disclosure schedule set forth by the SEC relating to the penny stock market must be delivered to the



18



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purchaser of such penny stock. This disclosure must include the amount of commissions payable to both the broker-dealer and the registered representative and current price quotations for the
common stock. The regulations also require that monthly statements be sent to holders of penny stock that disclose recent price information for the penny stock and information of the limited market for penny stocks. These requirements adversely
affect the market liquidity of our common stock.

Our net operating losses and research and development tax credits may
not be available to reduce future federal and state income tax payments.

At December 31, 2012, we had federal net
operating loss and tax credit carryforwards of $215.7 million and $7.6 million, respectively, and state net operating loss and tax credit carryforwards of $146.7 million and $7.8 million, respectively, available to offset future taxable income,
if any. Current federal and state tax laws include substantial restrictions on the utilization of net operating loss and tax credits in the event of an ownership change and we cannot assure you that our net operating loss and tax carryforwards will
continue to be available.



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|Item 2. | Properties
|------- | ----------

Our executive
offices are located in approximately 9,255 square feet of office space in South San Francisco, California that we occupy under a three-year operating lease expiring in June 2013. It is our intention to renew this lease for a multi-year period prior
to June 2013, and continue to be based in South San Francisco.



|Item 3. | Legal Proceedings
|------- | -----------------

We are
currently not a party to any material legal or administrative proceedings and are not aware of any pending or threatened legal or administrative proceedings against us.



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PART II



|Item 5. | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities.
|------- | -------------------------------------------------------------------------------------------------------------

(a) Price Range of Securities

Since June 2, 2010, our common stock has been quoted on the OTC Bulletin Board under the symbol TTNP.OB. The following table sets forth, for the periods indicated, the high and low sales prices per
share of our common stock as reported by the OTC Bulletin Board. The quotations reflect inter-dealer prices without retail markups, markdowns, or commissions and may not represent actual transactions. For current price information, stockholders are
urged to consult publicly available sources.



|               |  |      |      |  |     |   |      | 
|-------------- |  | ---- | ---- |  | --- | - | ---- | 
|               |  | High |      |  | Low |  
|Fiscal 2012    |  |      |      |  |     |   |      | 
|Fourth Quarter |  | $    | 1.23 |  |     | $ | 0.76 | 
|Third Quarter  |  | $    | 1.05 |  |     | $ | 0.65 | 
|Second Quarter |  | $    | 1.13 |  |     | $ | 0.65 | 
|First Quarter  |  | $    | 1.40 |  |     | $ | 1.05 | 
|               |  |     
|Fiscal 2011    |  |      |      |  |     |   |      | 
|Fourth Quarter |  | $    | 1.78 |  |     | $ | 1.06 | 
|Third Quarter  |  | $    | 2.08 |  |     | $ | 1.30 | 
|Second Quarter |  | $    | 2.22 |  |     | $ | 1.30 | 
|First Quarter  |  | $    | 1.81 |  |     | $ | 1.17 | 

(b) Approximate Number of Equity Security Holders

As of March 15, 2013, there were approximately 141 record holders of our common stock.

(c) Dividends

We have
never paid a cash dividend on our common stock and anticipate that for the foreseeable future any earnings will be retained for use in our business and, accordingly, do not anticipate the payment of cash dividends.



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Performance Graph

The information contained in the Performance Graph shall not be deemed to be soliciting material or filed with the SEC or subject to the liabilities of Section 18 of
the Securities Exchange Act of 1934, as amended (the Exchange Act), except to the extent that we specifically incorporate it by reference into a document filed under the Securities Act of 1933, as amended (the Securities
Act), or the Exchange Act.

The following graph compares the cumulative total stockholder return on our common stock
with the cumulative total stockholder return of (i) the NYSE MKT Index, and (ii) a peer group index consisting of companies reporting under the Standard Industrial Classification Code 2834 (Pharmaceutical Preparations). The graph assumes
$100 invested on December 31, 2007 and assumes dividends reinvested. Measurement points are at the last trading day of the fiscal years ended December 31, 2008, 2009, 2010, 2011 and 2012. The stock price performance on the following graph
is not necessarily indicative of future stock price performance.

COMPARE CUMULATIVE TOTAL RETURN

AMONG TITAN PHARMACEUTICALS, INC., NYSE MKT INDEX AND

SIC CODE INDEX



LOGO



22



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|Item 6. | Selected Financial Data.
|------- | ------------------------

The selected financial data presented below summarizes certain financial data which has been derived from and should be read in
conjunction with our consolidated financial statements and notes thereto included in the section beginning on page F-1. See also Item 7. Managements Discussion and Analysis of Financial Condition and Results of Operations.



|                                                                     |  |                                       |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |         |  
|-------------------------------------------------------------------- |  | ------------------------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------ | - |  | ---- | ------ | - |  | - | ------- | -
|                                                                     |  | Years Ended December 31,              |        
|                                                                     |  | 2012                                  |         |   | 2011 |   |         | 2010 |  |   | 2009   |   |  | 2008 |       
|                                                                     |  | (in thousands, except per share data) |        
|Statement of Operations Data:                                        |  |                                       |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |         |  
|Total revenue                                                        |  | $                                     | 7,117   |   |      | $ | 4,068   |      |  | $ | 10,093 |   |  | $    | 79     |   |  | $ | 73      |  
|Operating expenses:                                                  |  |                                       |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |         |  
|Research and development                                             |  |                                       | 10,610  |   |      |   | 11,206  |      |  |   | 12,855 |   |  |      | 2,456  |   |  |   | 16,235  |  
|General and administrative                                           |  |                                       | 4,877   |   |      |   | 3,368   |      |  |   | 3,263  |   |  |      | 3,438  |   |  |   | 9,756   |  
|Other income (expense), net                                          |  |                                       | (6,810  | ) |      |   | (4,697  | )    |  |   | (809   | ) |  |      | (71    | ) |  |   | 484     |  
|                                                                     |  |                                       |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |         |  
|Net loss                                                             |  |                                       | (15,180 | ) |      |   | (15,203 | )    |  |   | (6,834 | ) |  |      | (5,886 | ) |  |   | (25,434 | )
|Gain on retirement of preferred stock upon dissolution of subsidiary |  |                                       |        |   |      |   |        |      |  |   | 1,241  |   |  |      |       |   |  |   |        |  
|                                                                     |  |                                       |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |         |  
|Net loss applicable to common stockholders                           |  | $                                     | (15,180 | ) |      | $ | (15,203 | )    |  | $ | (5,593 | ) |  | $    | (5,886 | ) |  | $ | (25,434 | )
|                                                                     |  |                                       |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |         |  
|Basic and diluted net loss per common share                          |  | $                                     | (0.23   | ) |      | $ | (0.26   | )    |  | $ | (0.09  | ) |  | $    | (0.10  | ) |  | $ | (0.44   | )
|Shares used in computing:                                            |  |                                       |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |         |  
|Basic and diluted net loss per common share                          |  |                                       | 66,509  |   |      |   | 59,324  |      |  |   | 59,248 |   |  |      | 58,473 |   |  |   | 58,285  |  
|                                                                     | 
|                                                                     |  | As of December 31,                    |        
|                                                                     |  | 2012                                  |         |   | 2011 |   |         | 2010 |  |   | 2009   |   |  | 2008 |       
|                                                                     |  | (in thousands)                        |        
|Balance Sheet Data:                                                  |  |                                       |         |   |      |   |         |      |  |   |        |   |  |      |        |   |  |   |         |  
|Cash                                                                 |  | $                                     | 18,102  |   |      | $ | 5,406   |      |  | $ | 3,180  |   |  | $    | 3,300  |   |  | $ | 4,672   |  
|Working capital (deficit)                                            |  |                                       | 2,042   |   |      |   | 4,839   |      |  |   | (706   | ) |  |      | 2,069  |   |  |   | 2,759   |  
|Total assets                                                         |  |                                       | 24,827  |   |      |   | 10,217  |      |  |   | 4,752  |   |  |      | 3,726  |   |  |   | 5,668   |  
|Total stockholders (deficit) equity                                 |  |                                       | (23,128 | ) |      |   | (20,079 | )    |  |   | (6,053 | ) |  |      | (1,448 | ) |  |   | 1,793   |  



23



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|Item 7. | Managements Discussion and Analysis of Financial Condition and Results of Operations.
|------- | --------------------------------------------------------------------------------------

Forward-Looking Statements

Statements in the following discussion and throughout this report that are not historical in nature are forward-looking statements within the meaning of Section 27A of the Securities Act
and Section 21E of the Exchange Act. You can identify forward-looking statements by the use of words such as expect, anticipate, estimate, may, will, should,
intend, believe, and similar expressions. Although we believe the expectations reflected in these forward-looking statements are reasonable, such statements are inherently subject to risk and we can give no assurances that
our expectations will prove to be correct. Actual results could differ from those described in this report because of numerous factors, many of which are beyond our control. These factors include, without limitation, those described under
Item 1A Risk Factors. We undertake no obligation to update these forward-looking statements to reflect events or circumstances after the date of this report or to reflect actual outcomes. Please see Note Regarding
Forward-Looking Statements at the beginning of this Annual Report on Form 10-K.

The following discussion of our
financial condition and results of operations should be read in conjunction with our consolidated financial statements and the related notes thereto and other financial information appearing elsewhere in this Annual Report on Form 10-K.

Overview

We are a biopharmaceutical company developing proprietary therapeutics for the treatment of serious medical disorders. Our product development programs focus primarily on important pharmaceutical markets
with significant unmet medical needs and commercial potential. We are directly developing our product candidates and also utilize corporate, academic and government partnerships as appropriate. Such collaborations have helped to fund product
development and have enabled us to retain significant economic interest in our products.

Our principal
asset is Probuphine®, the first slow release implant formulation of buprenorphine, designed to maintain a
stable, around the clock blood level of the medicine in patients for six months following a single treatment. The clinical and manufacturing development of Probuphine for the treatment of opioid dependence in adult patients is complete. The NDA
seeking approval for treatment of opioid dependence has been accepted by the FDA for a Priority Review. Priority Review designation is given to therapies that offer potential major advances in treatment, including improved safety, or provide a
treatment where no adequate therapy exists. Based upon the PDUFA, the FDA has set a target date of April 30, 2013 for FDA action on the NDA. An FDA advisory committee review has been scheduled for March 21, 2013.

In December 2012, we entered into a license agreement with Braeburn that grants Braeburn exclusive commercialization
rights to Probuphine® in the United States and Canada. We received a non-refundable up-front license fee of
$15.75 million (approximately $15.0 million, net of expenses) and will receive a $50 million milestone payment upon the approval of the NDA by the FDA. Additionally, we will be eligible to receive up to $130 million upon achievement of specified
sales milestones and up to $35 million in regulatory milestones in the event of future NDA submissions and approvals for additional indications, including chronic pain. We will receive tiered royalties on net sales of Probuphine ranging from the
mid-teens to the low twenties. In addition to the potential milestone payments, Apple Tree Partners IV, Braeburns parent company, has allocated in excess of $75 million to launch, commercialize and continue the development of Probuphine.

Probuphine is the first product to utilize ProNeura, our novel, proprietary, continuous drug delivery technology. Our
ProNeura technology has the potential to be used in developing products for the treatment of other chronic conditions, such as Parkinsons disease, where maintaining stable, around the clock blood levels of a drug can benefit the patient and
improve medical outcomes.

Under a sublicense agreement with Novartis, we are entitled to royalty revenue
of 8-10% of net sales of Fanapt® (iloperidone), an atypical antipsychotic compound being marketed in the U.S. by
Novartis for the



24



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treatment of schizophrenia, based on a licensed U.S. patent that expires in October 2016 (excluding the potential of a six month pediatric extension). We have entered into several agreements with
Deerfield, a healthcare investment fund, which entitle Deerfield to most of the future royalty revenues related to Fanapt in exchange for cash and debt considerations, the proceeds from which we have been using to advance the development of
Probuphine and for general corporate purposes. We have retained a portion of the royalty revenue from the net sales of Fanapt in excess of specified annual threshold levels; however, based on sales levels to date, it is unlikely that we will receive
any revenue from Fanapt in the next several years, if ever.

Critical Accounting Policies and the Use of Estimates

The preparation of our financial statements in conformity with accounting principles generally accepted in the United
States requires management to make estimates and assumptions that affect the amounts reported in our consolidated financial statements and accompanying notes. Actual results could differ materially from those estimates. We believe the following
accounting policies for the years ended December 31, 2012 and 2011 to be applicable:

Revenue Recognition

We generate revenue principally from royalty payments, collaborative research and development arrangements, technology
licenses, and government grants. Consideration received for revenue arrangements with multiple components is allocated among the separate units of accounting based on their respective selling prices. The selling price for each unit is based on
vendor-specific objective evidence, or VSOE, if available, third party evidence if VSOE is not available, or estimated selling price if neither VSOE nor third party evidence is available. The applicable revenue recognition criteria are then applied
to each of the units.

Revenue is recognized when the four basic criteria of revenue recognition are met: (1) a
contractual agreement exists; (2) transfer of technology has been completed or services have been rendered; (3) the fee is fixed or determinable; and (4) collectibility is reasonably assured. For each source of revenue, we comply with
the above revenue recognition criteria in the following manner:



| |  |  | Royalties earned are based on third-party sales of licensed products and are recorded in accordance with contract terms when third-party results are
reliably measurable and collectibility is reasonably assured. Pursuant to certain license agreements, we earn royalties on the sale of Fanapt by Novartis in the U.S. As described in Note 8, Royalty Liability, we are obligated to pay royalties on such sales to Sanofi-Aventis and Deerfield. As we have
no performance obligations under the license agreements, we have recorded the royalties earned, net of royalties we are obligated to pay, as revenue in our Consolidated Statement of Operations.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Collaborative arrangements typically consist of non-refundable and/or exclusive technology access fees, cost reimbursements for specific research and
development spending, and various milestone and future product royalty payments. If the delivered technology does not have stand-alone value or if we do not have objective or reliable evidence of the fair value of the undelivered component, the
amount of revenue allocable to the delivered technology is deferred. Non-refundable upfront fees with stand-alone value that are not dependent on future performance under these agreements are recognized as revenue when received, and are deferred if
we have continuing performance obligations and have no evidence of fair value of those obligations. Cost reimbursements for research and development spending are recognized when the related costs are incurred and when collections are reasonably
expected. Payments received related to substantive, performance-based at-risk milestones are recognized as revenue upon achievement of the clinical success or regulatory event specified in the underlying contracts, which represent the
culmination of the earnings process. Amounts received in advance are recorded as deferred revenue until the technology is transferred, costs are incurred, or a milestone is reached.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



25



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| |  |  | Technology license agreements typically consist of non-refundable upfront license fees, annual minimum access fees or royalty payments. Non-refundable
upfront license fees and annual minimum payments received with separable stand-alone values are recognized when the technology is transferred or accessed, provided that the technology transferred or accessed is not dependent on the outcome of our
continuing research and development efforts.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Government grants, which support our research efforts in specific projects, generally provide for reimbursement of approved costs as defined in the
notices of grants. Grant revenue is recognized when associated project costs are incurred.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Share-Based
Payments

We recognize compensation expense for all share-based awards made to employees and directors. The fair value of
share-based awards is estimated at the grant date based on the fair value of the award and is recognized as expense, net of estimated pre-vesting forfeitures, ratably over the vesting period of the award. We use the Black-Scholes option pricing
model to estimate the fair value method of our awards. Calculating stock-based compensation expense requires the input of highly subjective assumptions, including the expected term of the share-based awards, stock price volatility, and pre-vesting
forfeitures. We estimate the expected term of stock options granted for the years ended December 31, 2012, 2011 and 2010 based on the historical experience of similar awards, giving consideration to the contractual terms of the share-based
awards, vesting schedules and the expectations of future employee behavior. We estimate the volatility of our common stock at the date of grant based on the historical volatility of our common stock. The assumptions used in calculating the fair
value of stock-based awards represent our best estimates, but these estimates involve inherent uncertainties and the application of management judgment. As a result, if factors change and we use different assumptions, our stock-based compensation
expense could be materially different in the future. In addition, we are required to estimate the expected pre-vesting forfeiture rate and only recognize expense for those shares expected to vest. We estimate the pre-vesting forfeiture rate based on
historical experience. If our actual forfeiture rate is materially different from our estimate, our stock-based compensation expense could be significantly different from what we have recorded in the current period.

Income Taxes

We make certain estimates and judgments in determining income tax expense for financial statement purposes. These estimates and judgments occur in the calculation of certain tax assets and liabilities,
which arise from differences in the timing of recognition of revenue and expense for tax and financial statement purposes.

As
part of the process of preparing our consolidated financial statements, we are required to estimate our income taxes in each of the jurisdictions in which we operate. This process involves us estimating our current tax exposure under the most recent
tax laws and assessing temporary differences resulting from differing treatment of items for tax and accounting purposes.

We
assess the likelihood that we will be able to recover our deferred tax assets. We consider all available evidence, both positive and negative, expectations and risks associated with estimates of future taxable income and ongoing prudent and feasible
tax planning strategies in assessing the need for a valuation allowance. If it is not more likely than not that we will recover our deferred tax assets, we will increase our provision for taxes by recording a valuation allowance against the deferred
tax assets that we estimate will not ultimately be recoverable.

Clinical Trial Accrual

We also record accruals for estimated ongoing clinical trial costs. Clinical trial costs represent costs incurred by clinical research
organizations, (CROs), and clinical sites. These costs are recorded as a component of research and development expenses. Under our agreements, progress payments are typically made to



26



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investigators, clinical sites and CROs. We analyze the progress of the clinical trials, including levels of patient enrollment, invoices received and contracted costs when evaluating the adequacy
of accrued liabilities. Significant judgments and estimates must be made and used in determining the accrued balance in any accounting period. Actual results could differ from those estimates under different assumptions. Revisions are charged to
expense in the period in which the facts that give rise to the revision become known. The actual clinical trial costs for the Probuphine studies conducted in the past three years have not differed materially from the estimated projection of
expenses.

Warrants Issued in Connection with Equity Financing

We generally account for warrants issued in connection with equity financings as a component of equity, unless there is a deemed
possibility that we may have to settle warrants in cash. For warrants issued with deemed possibility of cash settlement, we record the fair value of the issued warrants as a liability at each reporting period and record changes in the estimated fair
value as a non-cash gain or loss in the Condensed Consolidated Statements of Operations and Comprehensive Loss.

Liquidity and Capital Resources



|                                                |  |                |        |   |      |   |         |      |  |   |        |  
|----------------------------------------------- |  | -------------- | ------ | - | ---- | - | ------- | ---- |  | - | ------ | -
|                                                |  | 2012           |        |   | 2011 |   |         | 2010 | 
|                                                |  | (in thousands) |       
|As of December 31:                              |  |                |        |   |      |   |         |      |  |   |        |  
|Cash                                            |  | $              | 18,102 |   |      | $ | 5,406   |      |  | $ | 3,180  |  
|Working capital                                 |  | $              | 2,042  |   |      | $ | 4,839   |      |  | $ | (706   | )
|Current ratio                                   |  |                | 1.1:1  |   |      |   | 1.9:1   |      |  |   | 0.9:1  |  
|                                                |  |                |       
|Years Ended December 31:                        |  |                |        |   |      |   |         |      |  |   |        |  
|Cash (used in) provided by operating activities |  | $              | 1,830  |   |      | $ | (14,476 | )    |  | $ | (4,657 | )
|Cash used in investing activities               |  | $              | (1,154 | ) |      | $ | (234    | )    |  | $ | (28    | )
|Cash provided by financing activities           |  | $              | 12,020 |   |      | $ | 16,936  |      |  | $ | 4,565  |  

We have funded our operations since inception primarily through sales of our debt and equity securities,
as well as with proceeds from warrant and option exercises, corporate licensing and collaborative agreements, and government-sponsored research. At December 31, 2012, we had approximately $18.1 million of cash compared to approximately $5.4
million at December 31, 2011.

Our operating activities provided approximately $1.8 million during the year ended
December 31, 2012. This consisted primarily of the net loss for the period of approximately $15.2 million, approximately $0.3 million related to the non-cash interest expense on our royalty liability and approximately $1.4 million related to
net changes in operating assets and liabilities. This was offset in part by approximately $14.4 million related to deferred revenue in connection with the license agreement with Braeburn, approximately $1.8 million related to net non-cash losses on
changes in the fair value of warrants, non-cash charges of approximately $17,000 related to depreciation, and approximately $2.6 million related to stock-based compensation expenses. Uses of cash in operating activities were primarily to fund
product development programs and administrative expenses. The license agreement with Sanofi-Aventis require us to pay royalties on future product sales. In addition, in order to maintain license and other rights while products are under development,
we must comply with customary licensee obligations, including the payment of patent-related costs, annual minimum license fees, meeting project-funding milestones and diligent efforts in product development. The aggregate commitments we have under
these agreements, including minimum license payments, for the next 12 months is approximately $3,000. See Item 1. BusinessLicense Agreements.

Net cash used in investing activities of approximately $1.2 million during the year ended December 31, 2012 primarily related to purchases of equipment.



27



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Net cash provided by financing activities of approximately $12.0 million during the year
ended December 31, 2012 consisted of approximately $7.5 million of net proceeds from the sale of common stock and warrants, net of issuance costs and $4.9 million of net proceeds from the exercise of warrants to purchase common stock. This was
offset in part by payments of approximately $0.4 million related to payments on our long-term debt.

On March 15, 2011,
we entered into several agreements with entities affiliated with Deerfield pursuant to which Deerfield agreed to provide $20.0 million in funding to us. Funding occurred on April 5, 2011. Pursuant to the terms of a facility agreement, we issued
Deerfield 8.5% promissory notes in the aggregate principal amount of $20.0 million. We paid Deerfield a facility fee of $0.5 million and issued them warrants to purchase 6,000,000 shares of our common stock (the Deerfield Warrants).
Deerfield has the right to have the long-term debt repaid at 110% of the principal amount in the event we complete a major transaction, which includes, but is not limited to, a merger or sale of our company or the sale of Fanapt or Probuphine. Under
a royalty agreement, in exchange for $3.0 million that was recorded as royalty liability, we agreed to pay Deerfield 2.5% of the aggregate royalties on net sales of Fanapt, subsequent to the funding date, constituting a portion of the royalty
revenue we receive from Novartis. The agreements with Deerfield also provide us with the option to repurchase the royalty rights for $40.0 million.

On April 5, 2011, we used approximately $7.6 million of proceeds from the Deerfield funding to repay Oxford Financing Corporation in full, including required final payments aggregating $480,000.

On November 14, 2011, we entered into several agreements with Deerfield pursuant to which we agreed to pay them a
substantial portion of the remaining future royalties on the sales of Fanapt in exchange for $5.0 million in cash that was recorded as royalty liability, a $10.0 million reduction in the principal amount owed to Deerfield under the
existing facility agreement and a revised principal repayment schedule of $2.5 million per year for four years commencing in April 2013 to retire the remaining long-term debt of $10.0 million. Deerfield is entitled to the balance of our portion of
the royalties on Fanapt (5.5% to 7.5% of net sales, net of the 2.5% we previously agreed to pay to Deerfield) up to specified threshold levels of net sales of Fanapt and 40% of the royalties above the threshold level. We retain 60% of the royalties
on net sales of Fanapt above the threshold levels, subject to an agreement that half of any such retained royalties will go towards repayment of our outstanding debt to Deerfield. Funding of the transaction took place on November 25, 2011.

In February 2013, we amended the terms of the Deerfield Warrants, which are currently exercisable at $1.25 per share, to
permit payment of the exercise price through the reduction of the outstanding loan. In February and March 2013, Deerfield exercised an aggregate of 6,000,000 warrants resulting in a reduction of our outstanding indebtedness to Deerfield of $7.5
million and, accordingly, the Deerfield debt will be fully repaid upon payment of $2.5 million in April 2013.

On
April 9, 2012, we entered into subscription agreements with certain institutional investors for the purchase and sale, in a registered direct offering, of (i) 6,517,648 shares of our common stock (the Shares),
(ii) six-year warrants to purchase 6,517,648 shares of common stock (the Series A Warrants) and (iii) six-month warrants to purchase 6,517,648 shares of common stock (the Series B Warrants and, together with the
Series A Warrants, the Warrants) for gross proceeds of $5,540,000. The closing of the sale of the Shares and Warrants occurred on April 13, 2012 and April 18, 2012. Net proceeds were approximately $5.0 million. Prior to their
expiration, Series B Warrants to purchase 5,761,765 shares of our common stock were exercised resulting in gross proceeds to us of approximately $4.9 million.

On September 12, 2012, we entered into a stock purchase and option agreement with an affiliate of Braeburn pursuant to which we sold 3,400,000 shares of our common stock for an aggregate purchase
price of $4.25 million, or $1.25 per share, and agreed to an exclusive option period for execution of the proposed license agreement.



28



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On December 13, 2012, we entered into a license agreement with
Braeburn pursuant to which we granted Braeburn an exclusive right and license to commercialize Probuphine® in
the Territory. We will retain all of the rights to Probuphine® outside the Territory. In consideration of the
rights granted to Braeburn under the license agreement, Braeburn paid to us an upfront, non-refundable license fee of $15.75 million (approximately $15.0 million, net of expenses). Upon FDA approval of the NDA for Probuphine®, Braeburn will be required to make a $50 million milestone payment to us and ownership of the NDA will transfer to
Braeburn. We are also eligible to receive up to an additional $130 million upon the achievement of specified sales milestones and up to $35 million in regulatory milestones. Braeburn will also pay us tiered royalties ranging from the mid-teens to
the low twenties.

We believe that our working capital at December 31, 2012, together with the FDAs reimbursement
of the NDA filing fee, is sufficient to fund our planned operations through June 2014. In the event that the FDA issues a complete response letter requiring us to conduct additional clinical studies that would require expenditures in excess of
certain amounts specified in our agreement with Braeburn, Braeburn will have the right to either terminate the agreement or reduce the amount of the $50 million milestone payment payble to us in the event the FDA ultimately approves Probuphine. If
Braeburn were to terminate the agreement, we would not have sufficient funds available to us to complete the FDA approval process and commercialize Probuphine and, as a result, our business and prospects would be materially adversely impacted.
Furthermore, continuation of our current Parkinsons disease development program and the initiation of any additional programs will depend upon our receipt of the $50 million milestone payment and if such payment is not received or is
significantly reduced our ability to fund any new product development programs will be materially impaired and we may need to obtain additional financing, either through the sale of debt or equity securities, to continue our Probuphine program and
other product development activities. If we are unable to complete a debt or equity offering, or otherwise obtain sufficient financing when and if needed, we may be required to reduce, defer or discontinue one or more of our product development
activities.

The following table sets forth the aggregate contractual cash obligations as of December 31, 2012 (in
thousands):



|                                   |  |                        |        |  |          |   |       |           |  |   |           |  |  |          |       |  |  |   |   | 
|---------------------------------- |  | ---------------------- | ------ |  | -------- | - | ----- | --------- |  | - | --------- |  |  | -------- | ----- |  |  | - | - | 
|                                   |  | Payments Due by Period |       
|Contractual obligations            |  | Total                  |        |  | < 1 year |   |       | 1-3 years |  |   | 3-5 years |  |  | 5 years+ |      
|Operating leases                   |  | $                      | 121    |  |          | $ | 121   |           |  | $ |          |  |  | $        |      |  |  | $ |  | 
|Debt obligation(1)                 |  |                        | 11,771 |  |          |   | 3,262 |           |  |   | 5,885     |  |  |          | 2,624 |  |  |   |  | 
|                                   |  |                        |        |  |          |   |       |           |  |   |           |  |  |          |       |  |  |   |   | 
|Total contractual cash obligations |  | $                      | 11,892 |  |          | $ | 3,383 |           |  | $ | 5,885     |  |  | $        | 2,624 |  |  | $ |  | 
|                                   |  |                        |        |  |          |   |       |           |  |   |           |  |  |          |       |  |  |   |   | 



|(1) | Excludes payments related to the royalty liability with Deerfield under the March 2011 and November 2011 Royalty Agreements.
|--- | ----------------------------------------------------------------------------------------------------------------------------

Results of Operations

Year Ended December 31, 2012 Compared to Year Ended December 31, 2011

Our net loss applicable to common stockholders for 2012 was approximately $15.2 million, or approximately $0.23 per share, compared to our net loss applicable to common stockholders of approximately $15.2
million, or approximately $0.26 per share, for 2011. Our net loss for 2012 includes a non-cash loss of approximately $1.8 million resulting from increases in the fair value of warrants issued as part of the March 2011 Deerfield transaction and the
April 2012 financing transaction.

We generated royalty revenues during 2012 of approximately $4.8 million compared to
approximately $3.6 million during 2011. We generated grant revenues during 2012 of approximately $42,000 compared to approximately $0.5 million during 2011. We generated licensing revenues of approximately $2.3 million during 2012. The
licensing revenue consisted of approximately $1.7 million related to the premium paid on our common



29



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stock as part of the September 2012 stock purchase and option agreement with an affiliate of Braeburn and approximately $0.6 million related to the amortization of the non-refundable up-front
license fee of $15.75 million (approximately $15.0 million, net of expenses) related to our licensing agreement with Braeburn. There were no revenues from licensing agreements in 2011. Royalty revenues during 2012 and 2011 consisted of
royalties on sales of Fanapt. Grant revenues during 2012 and 2011 consisted of proceeds from NIH grants related to our Probuphine and ProNeura related programs.

Research and development expenses for 2012 were approximately $10.6 million compared to approximately $11.2 million in 2011, a decrease of approximately $0.6 million, or 5%. The decrease in research and
development costs was primarily associated with a decrease in external research and development expenses related to the Phase 3 clinical trials of our Probuphine product which were completed in 2011. This was offset by expenses related to the
preparation and submission of an NDA for a Probuphine product with the FDA in October 2012. External research and development expenses include direct expenses such as clinical research organization charges, investigator and review board fees,
patient expense reimbursements and contract manufacturing expenses. During 2012, our external research and development expenses relating to our Probuphine product development program were approximately $5.4 million compared to approximately
$7.7 million for 2011. Other research and development expenses include internal operating costs such as clinical research and development personnel-related expenses, clinical trials-related travel expenses, and allocation of facility and
corporate costs. As a result of the risks and uncertainties inherently associated with pharmaceutical research and development activities described elsewhere in this report, we are unable to estimate the specific timing and future costs of our
clinical development programs or the timing of material cash inflows, if any, from our products or product candidates.

General and administrative expenses for 2012 were approximately $4.9 million, compared to approximately $3.4 million in 2011, an increase
of approximately $1.5 million, or 44%. The increase in general and administrative expenses was primarily related to increases in non-cash stock compensation costs of approximately $0.8 million, employee-related costs of approximately $0.3 million,
consulting and professional fees of approximately $0.3 million, fees paid to members of our board of Directors of approximately $0.1 million and facilities-related costs of approximately $0.1 million. This was offset in part by decreases in
travel-related costs of approximately $0.1 million.

Net other expense for 2012 was approximately $6.8 million, compared
to approximately $4.7 million in 2011. The increase in net other expense during 2012 was primarily related to interest expense, net of approximately $4.9 million on the Deerfield long-term debt and a $1.8 million non-cash loss related to increases
in the fair value of the warrants issued to Deerfield and the warrants issued as part of the April 2012 financing transaction.

Year Ended December 31, 2011 Compared to Year Ended December 31, 2010

Our net loss applicable to common stockholders for 2011 was approximately $15.2 million, or approximately $0.26 per share, compared to our
net loss applicable to common stockholders of approximately $5.6 million, or approximately $0.09 per share, for 2010. Our net loss for 2011 includes a non-cash gain of $1.9 million resulting from changes in the fair value of warrants issued as
part of the March 2011 Deerfield transaction.

We generated royalty revenues during 2011 of approximately $3.6 million
compared to approximately $2.5 million during 2010. We generated grant revenues during 2011 of approximately $0.5 million compared to approximately $7.6 million during 2010. We generated no revenues from licensing agreements in 2011 compared to
approximately $24,000 during 2010. Royalty revenues during 2011 and 2010 consisted of royalties on sales of Fanapt. Grant revenues during 2011 and 2010 consisted of proceeds from the NIH grants related to our Probuphine and ProNeura related
programs.



30



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Research and development expenses for 2011 were approximately $11.2 million compared to
approximately $12.9 million in 2010, a decrease of approximately $1.7 million, or 13%. The decrease in research and development costs was primarily associated with a decrease in external research and development expenses related to the Phase 3
clinical trials of our Probuphine product which were completed in 2011. External research and development expenses include direct expenses such as clinical research organization charges, investigator and review board fees, patient expense
reimbursements and contract manufacturing expenses. During 2011, our external research and development expenses relating to our Probuphine product development program were approximately $7.7 million compared to approximately $10.1 million for 2010.
Other research and development expenses include internal operating costs such as clinical research and development personnel-related expenses, clinical trials-related travel expenses, and allocation of facility and corporate costs. As a result of
the risks and uncertainties inherently associated with pharmaceutical research and development activities described elsewhere in this report, we are unable to estimate the specific timing and future costs of our clinical development programs or the
timing of material cash inflows, if any, from our products or product candidates.

General and administrative expenses for
2011 were approximately $3.4 million, compared to approximately $3.3 million in 2010, an increase of approximately $0.1 million, or 3%. The increase in general and administrative expenses was primarily related to increases in non-cash stock
compensation costs of approximately $0.3 million, employee-related costs of approximately $0.3 million, marketing-related costs of approximately $0.2 million . This was offset in part by decreases in legal fees of approximately $0.3 million,
consulting and professional fees of approximately $0.3 million, and facilities-related costs of $0.1 million.

Net other
expense for 2011 was approximately $4.7 million, compared to approximately $0.8 million in 2010. The increase in net other expense during 2011 was primarily related to interest expense of approximately $6.2 million on the Deerfield long-term debt
and $0.2 million of interest expense related to the Oxford loans. This was offset in part by a $1.9 million non-cash gain related to decreases in the fair value of the Deerfield warrants.

Year Ended December 31, 2010 Compared to Year Ended December 31, 2009

Our net loss applicable to common stockholders for 2010 was approximately $5.6 million, or approximately $0.09 per share, compared to our
net loss applicable to common stockholders of approximately $5.9 million, or approximately $0.10 per share, for 2009. Our net loss for 2010 includes a non-cash gain of $1.2 million resulting from the retirement of preferred stock upon dissolution of
Ingenex, Inc., our majority-owned subsidiary.

We generated royalty revenues during 2010 of approximately $2.5 million. We had
no royalty revenue during 2009. We generated grant revenues during 2010 of approximately $7.6 million. We had no grant revenue during 2009. We generated revenues of $24,000 from licensing agreements in 2010 compared to approximately $79,000 during
2009. Royalty revenues during 2010 consisted of royalties on sales of Fanapt. Grant revenues during 2010 consisted of proceeds from the NIH grants related to our Probuphine and ProNeura related programs.

Research and development expenses for 2010 were approximately $12.9 million compared to approximately $2.5 million in 2009, an increase
of approximately $10.4 million, or 416%. The increase in research and development costs was primarily associated with an increase in external research and development expenses related to the initiation and ongoing expenses of the Phase 3 clinical
trials related to our Probuphine product. External research and development expenses include direct expenses such as clinical research organization charges, investigator and review board fees, patient expense reimbursements and contract
manufacturing expenses. During 2010, our external research and development expenses relating to our Probuphine product development program were approximately $10.1 million compared to approximately $0.7 million for 2009. Other research and
development expenses include internal operating costs such as clinical research and development personnel-related expenses, clinical trials-related travel expenses, and allocation of facility and corporate costs. As a result of the risks and
uncertainties inherently associated with pharmaceutical research and development



31



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activities described elsewhere in this report, we are unable to estimate the specific timing and future costs of our clinical development programs or the timing of material cash inflows, if any,
from our products or product candidates.

General and administrative expenses for 2010 were approximately $3.3 million,
compared to approximately $3.4 million in 2009, a decrease of approximately $0.1 million, or 3%. The decrease in general and administrative expenses was primarily related to decreases in non-cash stock compensation costs of approximately $0.7
million and facilities-related costs of $0.5 million. This was offset in part by increases in employee-related costs of approximately $0.2 million, legal fees of approximately $0.5 million, and consulting and professional fees of approximately $0.3
million.

Net other expense for 2010 was approximately $0.8 million compared to approximately $71,000 in 2009. Net other
expense in 2010 consisted primarily of interest expense of approximately $0.7 million and loan fees of approximately $0.1 million resulting from our loans with Oxford and tax-related expenses of approximately $6,000. Net other expense in 2009
consisted primarily of financing-related expenses of approximately $60,000, interest expense of approximately $9,000 and tax-related expenses of approximately $10,000 offset by interest income of approximately $2,000 and net gain of approximately
$6,000 resulting from the sale of certain assets.

Off-Balance Sheet Arrangements

We have never entered into any off-balance sheet financing arrangements and we have never established any special purpose entities. We
have not guaranteed any debt or commitments of other entities or entered into any options on non-financial assets.



|Item 7A. | Quantitative and Qualitative Disclosures About Market Risk
|-------- | ----------------------------------------------------------

We held no marketable securities at December 31, 2012 and 2011.



|Item 8. | Consolidated Financial Statements and Supplementary Data.
|------- | ---------------------------------------------------------

The response to this item is included in a separate section of this Report. See Index to Consolidated Financial Statements on Page F-1.



|Item 9. | Changes and Disagreements with Accountants on Accounting and Financial Disclosure.
|------- | ----------------------------------------------------------------------------------

None.



|Item 9A. | Controls and Procedures.
|-------- | ------------------------

(a) Evaluation of Disclosure Controls and Procedures: Our principal executive and financial officers reviewed and evaluated the
effectiveness of our disclosure controls and procedures (as defined in Exchange Act Rule 13a-15(e)) as of the end of the period covered by this Annual Report on Form 10-K. Based on that evaluation, our principal executive and financial officers
concluded that our disclosure controls and procedures are effective in timely providing them with material information relating to the Company, as required to be disclosed in the reports we file under the Exchange Act.

(b) Managements Annual Report on Internal Control Over Financial Reporting:

Internal control over financial reporting refers to the process designed by, or under the supervision of, our Principal Executive Officer
and Principal Financial Officer, and effected by our board of directors, management and other personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with generally accepted accounting principles, and includes those policies and procedures that:

(1) Pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of our assets;



32



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(2) Provide reasonable assurance that transactions are recorded as necessary
to permit preparation of financial statements in accordance with generally accepted accounting principles, and that our receipts and expenditures are being made only in accordance with authorization of our management and directors; and

(3) Provide reasonable assurance regarding prevention or timely detection of unauthorized acquisitions, use or disposition
of our assets that could have a material effect on the financial statements.

Internal control over financial reporting cannot
provide absolute assurance of achieving financial reporting objectives because of its inherent limitations. Internal control over financial reporting is a process that involves human diligence and compliance and is subject to lapses in judgment and
breakdowns resulting from human failures. Internal control over financial reporting also can be circumvented by collusion or improper management overrides. Due to such limitations, there is a risk that material misstatements may not be prevented or
detected on a timely basis by internal control over financial reporting. However, these inherent limitations are known features of the financial reporting process. Therefore, it is possible to design into the process safeguards to reduce, though not
eliminate, this risk. Management is responsible for establishing and maintaining adequate internal control over financial reporting for the company.

Management has used the framework set forth in the report entitled Internal ControlIntegrated Frameworkpublished by the Committee of Sponsoring Organizations of the Treadway Commission,
known as COSO, to evaluate the effectiveness of the Companys internal control over financial reporting. Based on this assessment, management has concluded that our internal control over financial reporting was effective as of December 31,
2012.

The attestation report concerning the effectiveness of our internal controls over financial reporting as of
December 31, 2012 issued by OUM & Co. LLP, an independent registered public accounting firm, appears in Item 8 of this Annual Report on Form 10-K.

(c) Changes in Internal Control Over Financial Reporting: There were no changes in our internal control over financial reporting (as defined in Rules 13(a)-15(f) and 15(d)-15(f) under the
Securities Act of 1934) during our most recent fiscal quarter that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

Item 9B. Other Information.

None.



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PART III



|Item 10. | Directors; Executive Officers and Corporate Governance
|-------- | ------------------------------------------------------

Set forth below are the name, age and position and a brief account of the business experience of each of our executive officers and directors:



|                              |  |     |  |                                 |  |               
|----------------------------- |  | --- |  | ------------------------------- |  | --------------
|Name                          |  | Age |  | Office                          |  | Director Since
|Marc Rubin (1)                |  | 58  |  | Executive Chairman of the Board |  | November 2007 
|Sunil Bhonsle                 |  | 63  |  | President and Director          |  | February 2004 
|Victor J. Bauer (2)(3)        |  | 77  |  | Director                        |  | November 1997 
|Eurelio M. Cavalier (1)(3)(4) |  | 80  |  | Director                        |  | September 1998
|Hubert E. Huckel (1)(2)(3)    |  | 81  |  | Director                        |  | October 1995  
|M. David MacFarlane (2)(4)    |  | 72  |  | Director                        |  | May 2002      
|Ley S. Smith (1)(2)(4)        |  | 78  |  | Director                        |  | July 2000     



|(1) | Member of Executive Committee
|--- | -----------------------------

|(2) | Member of Audit Committee
|--- | -------------------------

|(3) | Member of Compensation Committee
|--- | --------------------------------

|(4) | Member of Nominating Committee
|--- | ------------------------------

Marc Rubin, M.D. served as our President and Chief Executive from October 2007 until December 2008 and was re-engaged as our
Executive Chairman in May 2009. Until February 2007, Dr. Rubin served as Head of Global Research and Development for Bayer Schering Pharma, as well as a member of the Executive Committee of Bayer Healthcare and the Board of Management of Bayer
Schering Pharma. Prior to the merger of Bayer Pharmaceuticals and Schering AG in June 2006, Dr. Rubin was a member of the Executive Board of Schering AG since joining the Company in October 2003, as well as Chairman of Schering Berlin Inc. and
President of Berlex Pharmaceuticals, a division of Schering AG. From 1990 until August 2003, Dr. Rubin was employed by GlaxoSmithKline where he held positions of increasing responsibility in global clinical and commercial development overseeing
programs in the United States, Europe, Asia and Latin America. From 2001 through 2003, he was Senior Vice President of Global Clinical Pharmacology & Discovery Medicine. Dr. Rubin holds an M.D. from Cornell University Medical College.
Dr. Rubin currently serves on the board of directors of Curis Inc. and Galectin Therapeutics.

Sunil Bhonsle
served as our Executive Vice President and Chief Operating Officer from September 1995 until December 2008 and was re-engaged as our President in May 2009. Mr. Bhonsle served in various positions, including Vice President and General
ManagerPlasma Supply and ManagerInventory and Technical Planning, at Bayer Corporation from July 1975 until April 1995. Mr. Bhonsle holds an M.B.A. from the University of California at Berkeley and a B.Tech. in chemical engineering
from the Indian Institute of Technology.

Victor J. Bauer, Ph.D. serves as the Executive Vice President of Concordia
Pharmaceuticals, LLC, a biopharmaceutical company he co-founded in 2004. From February 1997 through March 2003, Dr. Bauer was employed by Titan, most recently as our Executive Director of Corporate Development. From April 1996 until its merger
into Titan, Dr. Bauer also served as a director and Chairman of Theracell. From December 1992 until February 1997, Dr. Bauer was a self-employed consultant to companies in the pharmaceutical and biotechnology industries. Prior to that
time, Dr. Bauer was with Hoechst-Roussel Pharmaceuticals Inc., where he served as President from 1988 through 1992.

Eurelio M. Cavalier was employed in various capacities by Eli Lilly & Co. from 1958 until his retirement in 1994, serving
as Vice President Sales from 1976 to 1982 and Group Vice President U.S. Pharmaceutical Business Unit from 1982 to 1993.



34



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Hubert E. Huckel, M.D.served in various positions with The Hoechst Group from 1964
until his retirement in December 1992. At the time of his retirement, Dr. Huckel was Chairman of the Board of Hoechst-Roussel Pharmaceuticals, Inc., Chairman and President of Hoechst-Roussel Agri-Vet Company and a member of the Executive
Committee of Hoechst Celanese Corporation. Dr. Huckel co-founded Concordia Pharmaceuticals, LLC, a biopharmaceutical company, in 2004. He currently serves on the board of directors of Catalyst Pharmaceuticals, Inc. and Concordia
Pharmaceuticals, LLC.

M. David MacFarlane, Ph.D.served as Vice President and Responsible Head of Regulatory Affairs
of Genentech, Inc. from 1989 until his retirement in August 1999. Prior to joining Genentech, Inc., he served in various positions with Glaxo Inc., last as Vice President of Regulatory Affairs.

Ley S. Smith served in various positions with The Upjohn Company and Pharmacia & Upjohn from 1958 until his retirement in
November 1997. From 1991 to 1993 he served as Vice Chairman of the Board of The Upjohn Company, and from 1993 to 1995 he was President and Chief Operating Officer of The Upjohn Company. At the time of his retirement, Mr. Smith was Executive
Vice President of Pharmacia & Upjohn, and President of Pharmacia & Upjohns U.S. Pharma Product Center.

As indicated above, each of our directors has extensive management and operational experience in one or more facets of the pharmaceutical
industry, including research, product development, clinical and regulatory affairs, manufacturing and sales and marketing, providing our company with the leadership needed by a biotechnology company in all stages of its development.

Directors serve until the next annual meeting or until their successors are elected and qualified. Officers serve at the discretion of
the board of directors, subject to rights, if any, under contracts of employment. See Item 6. Executive CompensationEmployment Agreements.

Board Leadership Structure

Currently, our principal executive officer and
chairman of the board positions are held separately by Sunil Bhonsle and Marc Rubin, respectively.

Section 16(a) Beneficial
Ownership Reporting Compliance

Section 16(a) of the Securities Exchange Act of 1934, as amended (the Exchange
Act), requires our executive officers, directors and persons who beneficially own more than 10% of a registered class of our equity securities to file with the Securities and Exchange Commission initial reports of ownership and reports of
changes in ownership of our common stock and other equity securities. Such executive officers, directors, and greater than 10% beneficial owners are required by SEC regulation to furnish us with copies of all Section 16(a) forms filed by such
reporting persons.

Based solely on our review of such forms furnished to us and written representations from certain
reporting persons, we believe that all filing requirements applicable to our executive officers, directors and greater than 10% beneficial owners were complied with during 2012.

Code of Ethics

We have adopted a Code of Business Conduct and Ethics (the
Code) that applies to our directors, officers and employees, including our principal executive officer and principal financial and accounting officer, respectively. The Code is filed as Exhibit 14.1 here to and is incorporated by
reference into this annual report. A written copy of the Code will be provided upon request at no charge by writing to our Chief Financial Officer, Titan Pharmaceuticals, Inc., 400 Oyster Point Boulevard, Suite 505, South San Francisco, California
94080.

Changes in Director Nomination Process for Stockholders

None.



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Formation of Audit Committee and Financial Expert

The Audit Committee (which is formed in compliance with Section 3(a)(58)(A) of the Securities Exchange Act of 1934) consists of Ley
S. Smith, M. David MacFarlane, Victor J. Bauer and Hubert E. Huckel, each of whom meets the independence requirements and standards currently established by the NYSE Amex (formerly the American Stock Exchange) and the SEC. In addition, the Board of
Directors has determined that Mr. Ley Smith is an audit committee financial expert and independent as defined under the relevant rules of the SEC and the NYSE Amex.



|Item 11. | Executive Compensation
|-------- | ----------------------

Compensation
Committee Report

The Compensation Committee has reviewed and discussed with management the following discussion and
analysis of our executive compensation included in this Annual Report on Form 10-K. Based on such review and discussion with management, the Compensation Committee recommended to the board of directors that the following disclosure be included in
this Annual Report on Form 10-K for the fiscal year ended December 31, 2012.

The Compensation Committee:

Eurelio M. Cavalier

Hubert E. Huckel

Victor J. Bauer

Overview

During 2010,
2011 and 2012, Dr. Rubin and Mr. Bhonsle continued as our Executive Chairman and President, respectively, with compensation packages structured to reflect our current level of operations and resources. This compensation discussion
describes the material elements of compensation awarded to, earned by, or paid to each of our executive officers who served as named executive officers during the year ended December 31, 2012. This compensation discussion focuses on the
information contained in the following tables and related footnotes and narrative for primarily the last completed fiscal year; however, we also describe compensation actions taken before or after the last completed fiscal year to the extent it
enhances the understanding of our executive compensation disclosure.

Compensation Program Objectives and Philosophy

Our Compensation Committee currently oversees the design and administration of our executive compensation program. It reviews and approves
all elements of compensation for each of our named executive officers taking into consideration recommendations from our principal executive officer (for compensation other than his own), as well as competitive market guidance. We define our
competitive markets for executive talent to be the pharmaceutical and biotechnology industries in northern California. To date, we have utilized the Radford Biotechnology Surveys, a third party market specific compensation survey, and, when
applicable, other independent third-party compensation consultants to benchmark our executive compensation.

The principal
elements of our executive compensation program have historically been base salary, annual cash incentives, long-term equity incentives in the form of stock options, other benefits and perquisites, post-termination severance and acceleration of stock
option vesting for certain named executive officers upon termination and/or a change in control. Our other benefits and perquisites have consisted of life, health and disability insurance benefits, and a qualified 401(k) savings plan. Our philosophy
has been to position the aggregate of these elements at a level that is competitive within the industry and commensurate with our size and performance. During 2012, our compensation philosophy has continued to evolve to accommodate our changing
circumstances, operational needs and limited financial resources during this period.



36



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During 2012, our operations continued to focus on efforts to realize maximum shareholder
value from activities associated with our Probuphine and ProNeura development programs. Accordingly, our Compensation Committee continued a compensation plan which provides base salary and potential earnings through stock option and restricted stock
awards.

During 2011and 2010, our operations continued to focus on efforts to realize maximum shareholder value from both
Fanapt and activities associated with our Probuphine development program. Accordingly, our Compensation Committee implemented a compensation plan which provides base salary and potential earnings through stock option and restricted stock awards.

Base Salaries

During 2012, the base salary of our named executives was reflective of the availability of resources and level of continuing operations.
Dr. Rubin continues to receive an annual salary of $210,000 and Mr. Bhonsle continues to receive an annual salary of $300,000 through December 31, 2013, at which time we expect to have new compensation arrangements in place. In the
event new compensation arrangements with Dr. Rubin and Mr. Bhonsle have not been determined prior to December 31, 2013, Dr. Rubin and Mr. Bhonsle will either (i) make a determination to continue their employment at
their then existing respective compensation levels or (ii) terminate their employment arrangements with our company. See Employment Agreements below. In December 2012, following the completion of the License Agreement,
Dr. Rubin and Mr. Bhonsle received cash bonuses of $53,000 and 75,000, respectively.

During 2011, the base salary
of our named executives was reflective of the availability of resources and level of continuing operations. As a result of an amendment to his employment agreement, effective January 1, 2011, Dr. Rubin began receiving an annual salary of
$210,000 and Mr. Bhonsle continued to receive an annual salary of $300,000 through December 31, 2011.

During 2010,
the base salary of our named executives was reflective of the availability of resources and level of continuing operations. Dr. Rubin did not receive a cash salary during 2010. As a result of an amendment to his employment agreement, effective
March 1, 2010, Mr. Bhonsles base annual salary was set at $300,000, essentially his 2008 level.

As we
continue to evaluate the strategic alternatives for us going forward and our related human resource requirements, our Compensation Committee will continue to review appropriate base salaries for our executive officers. In making its determination,
the Compensation Committee will consider the time commitment necessary and the roles our executives will play in implementing our plans.

Long-term Equity Incentives

We provide the opportunity for our named executive officers and other executives to earn a long-term equity incentive award. Long-term incentive awards provide employees with the incentive to stay with us
for longer periods of time, which in turn, provides us with greater stability. Equity awards also are less costly to us in the short term than cash compensation. We review long-term equity incentives for our named executive officers and other
executives annually.

Historically, for our named executive officers, our stock option grants were of a size and term
determined and approved by the Compensation Committee in consideration of the range of grants in the Radford Survey, generally falling within the 50-75% range outlined in the survey. We have traditionally used stock options as our form of equity
compensation because stock options provide a relatively straightforward incentive for our executives, result in less immediate dilution of existing shareholders interests and, prior to our adoption of FAS 123(R), resulted in less compensation
expense for us relative to other types of equity awards. Generally, all grants of stock options to our employees were granted with exercise prices equal to or greater than the fair



37



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market value of our common stock on the respective grant dates. For a discussion of the determination of the fair market value of these grants, see Managements Discussion and Analysis
of Financial Condition and Results of OperationsCritical Accounting Policies and the Use of Estimates.

We do not
time stock option grants to executives in coordination with the release of material non-public information. Our stock option grants have a 10-year contractual exercise term. In general, the option grants are also subject to the following
post-termination and change in control provisions:



|                                                                         |  |                                           |  |                                                             
|------------------------------------------------------------------------ |  | ----------------------------------------- |  | ------------------------------------------------------------
|Event                                                                    |  | Award Vesting                             |  | Exercise Term                                               
|     Termination by us for Reason Other than Cause, Disability or Death |  |      Forfeit Unvested Options            |  |      Earlier of: (1) 90 days or (2) Remaining Option Period
|                                                                         |  |                                          
|     Termination for Disability, Death or Retirement                    |  |      Forfeit Unvested Options            |  |      Earlier of: (1) 2 years or (2) Remaining Option Period
|                                                                         |  |                                          
|     Termination for Cause                                              |  |      Forfeit Vested and Unvested Options |  |      Expire                                                
|                                                                         |  |                                          
|     Other Termination                                                  |  |      Forfeit Unvested Options            |  |      Earlier of: (1) 90 days or (2) Remaining Option Period
|                                                                         |  |                                          
|     Change in Control                                                  |  |      Accelerated*                        |  |      *                                                     



|* | The Compensation Committee may provide that, in the event of a change in control, any outstanding awards that are unexercisable or otherwise unvested will become fully
vested and immediately exercisable. If there is a termination of employment, the applicable termination provisions regarding exercise term will apply.
|- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The vesting of certain of our named executive officers stock options is accelerated pursuant to the terms of their employment agreements in certain change in control or other material events. These
terms are more fully described in Employment Agreements and Potential Payments upon Termination or Change in Control.

In May 2009, Dr. Rubin was awarded a stock option grant of 1,000,000 shares with immediate vesting of 25% of the grant and the remainder to vest monthly over four years. This was the only
compensation provided to Dr. Rubin during 2009. During 2010, Dr. Rubin was awarded 36,000 and 82,800 shares of restricted stock in May and July 2010, respectively. These awards vested over four and six month periods with all restricted
shares fully vested by December 31, 2010. Similarly, upon the confirmation of Mr. Bhonsle as the President, he was awarded a stock option grant to purchase 700,000 shares of common stock with immediate vesting of 25% and the remainder to
vest monthly over four years. During 2011, Dr. Rubin was awarded a stock option grant to purchase 150,000 shares of common stock with the vesting of 25% after six months and the remainder to vest monthly over the following 18 months. During
2011, Mr. Bhonsle was awarded a stock option grant to purchase 200,000 shares of common stock with the vesting of 25% after six months and the remainder to vest monthly over the following 18 months. During 2012, Dr. Rubin was awarded a
fully vested stock option grant to purchase 250,000 shares of common stock. During 2012, Mr. Bhonsle was awarded a fully vested stock option grant to purchase 300,000 shares of common stock.

Compensation Committee Interlocks and Insider Participation

Members of our Compensation Committee of the board of directors were Eurelio M. Cavalier, Hubert E. Huckel and Victor J. Bauer. No member of our Compensation Committee was, or has been, an
officer or employee of Titan or any of our subsidiaries, except for Victor J. Bauer, who was employed by Titan from February 1997 through March 2003 as our Executive Director of Corporate Development and from April 1996 until its merger into Titan,
Dr. Bauer also served as a Director and Chairman of a former subsidiary.

No member of the Compensation Committee has a
relationship that would constitute an interlocking relationship with executive officers or directors of the Company or another entity.



38



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SUMMARY COMPENSATION TABLE

The following table shows information concerning the annual compensation for services provided to us by our Chief Executive Officer, our
Chief Financial Officer and our other executive officers for the periods set forth.



|                                                   |  |      |      |  |            |         |         |          |  |   |               |  |  |              |         |  |                          |         |   |                      |  |   |   |  |  |         |         | 
|-------------------------------------------------- |  | ---- | ---- |  | ---------- | ------- | ------- | -------- |  | - | ------------- |  |  | ------------ | ------- |  | ------------------------ | ------- | - | -------------------- |  | - | - |  |  | ------- | ------- | 
|Name and Principal Position(1)                     |  | Year |      |  | Salary ($) |         |         | Bonus($) |  |   | Options(2)($) |  |  | Awards(2)($) |         |  | All OtherCompensation($) |         |   | TotalCompensation($) | 
|Marc Rubin, M.D.(3)(4) Executive Chairman          |  |      | 2012 |  |            | $       | 210,000 |          |  | $ | 53,000        |  |  | $            | 273,450 |  |                          | $       |  |                      |  | $ |  |  |  | $       | 536,450 | 
|                                                   |  | 2011 |      |  |            | 210,000 |         |          |  |  |               |  |  | 201,015      |         |  |                          |        |   |                      |  |  |   |  |  | 411,015 |        
|                                                   |  | 2010 |      |  |            |        |         |          |  |  |               |  |  |             |         |  |                          | 152,982 |   |                      |  |  |   |  |  | 152,982 |        
|                                                   |  |      |      |  |            |         |        
|Louis R. Bucalo, M.D.(5) Former Executive Chairman |  |      | 2012 |  |            |         |        |          |  |   |              |  |  |              |        |  |                          |         |  |                      |  |   |  |  |  |         |        | 
|                                                   |  | 2011 |      |  |            |        |         |          |  |  |               |  |  |             |         |  |                          |        |   |                      |  |  |   |  |  |        |        
|                                                   |  | 2010 |      |  |            | 70,312  |         |          |  |  |               |  |  |             |         |  |                          |        |   |                      |  |  |   |  |  | 70,312  |        
|                                                   |  |      |      |  |            |         |        
|Sunil BhonslePresident and Chief Financial Officer |  |      | 2012 |  |            |         | 300,000 |          |  |   | 75,000        |  |  |              | 328,140 |  |                          |         |  |                      |  |   |  |  |  |         | 703,140 | 
|                                                   |  | 2011 |      |  |            | 300,000 |         |          |  |  |               |  |  | 268,020      |         |  |                          |        |   |                      |  |  |   |  |  | 568,020 |        
|                                                   |  | 2010 |      |  |            | 277,473 |         |          |  |  |               |  |  |             |         |  |                          |        |   |                      |  |  |   |  |  | 277,473 |        



|(1) | The positions listed are the most recent held by such individuals.
|--- | ------------------------------------------------------------------

|(2) | Amounts shown represent the grant date fair value computed in accordance with FASB ASC 718. The assumptions used by us with respect to the valuation of option grants
and stock awards are set forth in Titan Pharmaceuticals, Inc. Consolidated Financial StatementsNotes to Consolidated Financial StatementsNote 12Stock Plans.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Dr. Rubin did not receive a salary during 2010.
|--- | -----------------------------------------------

|(4) | Dr. Rubin was awarded 36,000 and 82,800 shares of restricted stock on March 1, 2010 and July 1, 2010, respectively, instead of a cash salary. These
shares were fully vested as of December 31, 2010.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | Dr. Bucalos employment was terminated in April 2008 and he received salary continuation payments until April 2010. During 2010, Dr. Bucalo received
salary continuation payments of $70,312, respectively. His outstanding options continued to vest under the terms of his severance agreement through April 2010, at which time they were cancelled unexercised.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

For a description of the material terms of employment agreements with our current and former named executive officers, see
Employment Agreements.



39



---

GRANTS OF PLAN-BASED AWARDS



|                 |  |           |          |  |                 |  |            |                                                     |  |  |                                            |     |  |                                                    |      |  |  |   |         | 
|---------------- |  | --------- | -------- |  | --------------- |  | ---------- | --------------------------------------------------- |  |  | ------------------------------------------ | --- |  | -------------------------------------------------- | ---- |  |  | - | ------- | 
|Name             |  | GrantDate |          |  | ApprovalDate(1) |  |            | Number ofShares ofCommon StockUnderlyingOptions (#) |  |  | Exercise orBase Price ofOptionAwards($/Sh) |     |  | Grant DateFair Valueof Stockand OptionAwards($)(2) |     
|Marc Rubin, M.D. |  |           | 1/3/2012 |  |                 |  | 12/28/2011 |                                                     |  |  | 250,000                                    | (3) |  | $                                                  | 1.15 |  |  | $ | 273,450 | 
|Sunil Bhonsle    |  |           | 1/3/2012 |  |                 |  | 12/28/2011 |                                                     |  |  | 300,000                                    | (3) |  | $                                                  | 1.15 |  |  | $ | 328,140 | 



|(1) | All grants were approved by the Compensation Committee on the dates indicated.
|--- | ------------------------------------------------------------------------------

|(2) | Valuation assumptions are found under Titan Pharmaceuticals, Inc. Consolidated Financial StatementsNotes to Consolidated Financial StatementsNote
12Stock Plans.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | These options were 100% vested on the grant date.
|--- | -------------------------------------------------

Employee Benefits Plans

The principal purpose of our stock incentive plans
is to attract, motivate, reward and retain selected employees, consultants and directors through the granting of stock-based compensation awards. The stock option plans provides for a variety of awards, including non-qualified stock options,
incentive stock options (within the meaning of Section 422 of the Code), stock appreciation rights, restricted stock awards, performance-based awards and other stock-based awards.

2002 Stock Incentive Plan

In July 2002, we adopted the 2002 Stock Incentive Plan, or the 2002 Plan. Under the 2002 Plan, as amended, a total of approximately 7.4 million shares of our common stock were authorized for issuance
to employees, officers, directors, consultants, and advisers.

The 2002 Plan expired by its terms in July 2012. Options to
purchase an aggregate of 4,280,153 shares of our common stock are currently outstanding under the 2002 Plan.

2001 Stock
Option Plan

In August 2001, we adopted the 2001 Employee Non-Qualified Stock Option Plan, or the 2001 NQ Plan,
pursuant to which 1,750,000 shares of common stock were authorized for issuance for option grants to employees and consultants who are not officers or directors of Titan. The 2001 Stock Option Plan expired by its terms in August 2011. Options to
purchase an aggregate of 1,199,500 shares of our common stock are currently outstanding under the 2001 NQ Plan.



40



---

OUTSTANDING EQUITY AWARDS AT FISCAL YEAR-END

The following table summarizes the number of securities underlying outstanding plan awards for each named executive officer as of
December 31, 2012.



|                 |  |                                                                   |         |  |                                                                    |  |        |                          |  |   |                       |  |  |  |            | 
|---------------- |  | ----------------------------------------------------------------- | ------- |  | ------------------------------------------------------------------ |  | ------ | ------------------------ |  | - | --------------------- |  |  |  | ---------- | 
|                 |  | Option Awards                                                     |        
|Name             |  | Number ofSecurities UnderlyingUnexercised Options 
(#)Exercisable |         |  | Number ofSecurities UnderlyingUnexercised Options(#) Unexercisable |  |        | Option ExercisePrice ($) |  |   | Option ExpirationDate | 
|Marc Rubin, M.D. |  |                                                                   | 437,500 |  |                                                                    |  |       |                          |  | $ | 2.40                  |  |  |  | 10/01/2017 | 
|                 |  |                                                                   | 2,500   |  |                                                                    |  |       |                          |  |   | 1.52                  |  |  |  | 5/30/2018  | 
|                 |  |                                                                   | 5,000   |  |                                                                    |  |       |                          |  |   | 1.52                  |  |  |  | 5/30/2018  | 
|                 |  |                                                                   | 550,937 |  |                                                                    |  | 64,063 | (1)                      |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 100,000 |  |                                                                    |  |       |                          |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 5,000   |  |                                                                    |  |       |                          |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 10,000  |  |                                                                    |  |       |                          |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 270,938 |  |                                                                    |  | 14,062 | (1)                      |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 125,000 |  |                                                                    |  | 25,000 | (3)                      |  |   | 1.40                  |  |  |  | 4/15/2021  | 
|                 |  |                                                                   | 250,000 |  |                                                                    |  |       |                          |  |   | 1.15                  |  |  |  | 1/3/2022   | 
|Sunil Bhonsle    |  |                                                                   | 50,000  |  |                                                                    |  |       |                          |  |   | 1.50                  |  |  |  | 3/1/2013   | 
|                 |  |                                                                   | 60,000  |  |                                                                    |  |       |                          |  |   | 3.69                  |  |  |  | 2/9/2014   | 
|                 |  |                                                                   | 70,000  |  |                                                                    |  |       |                          |  |   | 2.62                  |  |  |  | 2/7/2015   | 
|                 |  |                                                                   | 80,137  |  |                                                                    |  |       |                          |  |   | 1.40                  |  |  |  | 1/3/2016   | 
|                 |  |                                                                   | 11,250  |  |                                                                    |  |       |                          |  |   | 2.35                  |  |  |  | 8/29/2016  | 
|                 |  |                                                                   | 76,666  |  |                                                                    |  |       |                          |  |   | 3.13                  |  |  |  | 1/3/2017   | 
|                 |  |                                                                   | 5,000   |  |                                                                    |  |       |                          |  |   | 1.52                  |  |  |  | 5/30/2018  | 
|                 |  |                                                                   | 277,710 |  |                                                                    |  | 32,290 | (2)                      |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 100,000 |  |                                                                    |  |       |                          |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 10,000  |  |                                                                    |  |       |                          |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 367,604 |  |                                                                    |  | 22,396 | (2)                      |  |   | 0.79                  |  |  |  | 5/17/2019  | 
|                 |  |                                                                   | 166,667 |  |                                                                    |  | 33,333 | (3)                      |  |   | 1.40                  |  |  |  | 4/15/2021  | 
|                 |  |                                                                   | 300,000 |  |                                                                    |  |       |                          |  |   | 1.15                  |  |  |  | 1/3/2022   | 



|(1) | These options vest in 48 equal monthly installments beginning on May 17, 2009.
|--- | ------------------------------------------------------------------------------

|(2) | These options vest in 48 equal monthly installments beginning on May 17, 2009, with the vesting of 100,000 shares contingent upon the sale or partnering of the
Probuphine program.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | These options vest over a 24 month period beginning on April 15, 2011 with 25% vesting after six months and the balance vesting in 18 monthly installments over the
remaining vesting period.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

No options were exercised by our named executive officers during 2012.

Pension Benefits

We do
not sponsor any qualified or non-qualified defined benefit plans.

Nonqualified Deferred Compensation

We do not maintain any non-qualified defined contribution or deferred compensation plans. The Compensation Committee, which is comprised
solely of outside directors as defined for purposes of Section 162(m) of the Code, may elect to provide our officers and other employees with non-qualified defined contribution or deferred compensation benefits if the Compensation
Committee determines that doing so is in our best interests. We sponsor a tax qualified defined contribution 401(k) plan in which Dr. Rubin, Mr. Bhonsle and Dr. Bucalo participated.



41



---

Employment Agreements

Marc Rubin

In May 2009, in connection with our re-engagement of our
executive officers following the FDAs approval of Fanapt, we entered into a new employment agreement with Dr. Rubin to serve as our Executive Chairman (the Rubin Agreement). Pursuant to the Rubin Agreement, as such
agreement was amended effective March 1, 2010, June 15, 2010 and December 27, 2010, he received no cash salary through December 2010. In May 2009, we granted Dr. Rubin options to purchase 1,000,000 shares of our common stock
that vest as follows: 25% immediately and the balance monthly over a four-year period. Notwithstanding the foregoing, all unvested options held by Dr. Rubin automatically will become vested and exercisable immediately prior to the occurrence of
a change of control. One half of the options will accelerate in the event we sell or transfer all or substantially all of our rights in iloperidone. In addition, in the event that we declare a dividend or similar distribution following such sale or
transfer, we have agreed to retain for Dr. Rubins benefit an amount equal to the dividend amount for distribution to him only upon the actual vesting and exercise by him of the unvested options. In consideration for entering into the
March 1, 2010 amendment agreement, we issued Dr. Rubin 36,000 restricted shares that vested in four monthly installments through June 30, 2010. In consideration for entering into the June 15, 2010 amendment agreement, we issued
Dr. Rubin 82,800 restricted shares that vested in six monthly installments through December 31, 2010. In consideration for entering into the December 27, 2010 amendment agreement, we agreed to pay Dr. Rubin an annual salary of
$210,000 for the period of January 1, 2011 through December 31, 2011. On December 30, 2011, we agreed to extend the term of Dr. Rubins employment with us through December 31, 2012 at an annual salary of $210,000 for
the period of January 1, 2012 through December 31, 2012. On December 31, 2012, we agreed to extend the term of Dr. Rubins employment with us through December 31, 2013 at an annual salary of $210,000 for the period of
January 1, 2013 through December 31, 2013. The Rubin Agreement contains non-competition provisions applicable during the term of employment.

Sunil Bhonsle

In May 2009, in connection with our re-engagement of
our executive officers following the FDAs approval of Fanapt, we entered into a new employment agreement with Mr. Bhonsle to serve as our President (the Bhonsle Agreement). The Bhonsle Agreement provided that until
February 28, 2010, he was entitled to a cash salary of $200,000 per annum, payment of which was deferred until we began receiving royalty payments from Fanapt. Mr. Bhonsle was granted options to purchase 700,000 shares of our common stock
that vest as follows: 25% immediately and the balance monthly over a four-year period; provided, however, that the vesting of 100,000 shares is also contingent upon the sale or partnering of the Probuphine program. Notwithstanding the foregoing, all
unvested options held by Mr. Bhonsle automatically will become vested and exercisable immediately prior to the occurrence of a change of control. Effective March 1, 2010, we amended the Bhonsle Agreement to provide that from the effective
date through June 30, 2010, he was entitled to a salary of $300,000 per annum. The amendment also provides that one half of the options will accelerate in the event we sell or transfer all or substantially all of our rights in iloperidone. In
addition, in the event that we declare a dividend or similar distribution following such sale or transfer, we have agreed to retain for Mr. Bhonsles benefit an amount equal to the dividend amount for distribution to him only upon the
actual vesting and exercise by him of the unvested options. Effective July 1, 2010, as further amended effective December 27, 2010 and December 30, 2011, we amended the Bhonsle Agreement to provide that Mr. Bhonsle would continue
to be entitled to a salary of $300,000 per annum through December 31, 2012. On December 31, 2012, we agreed to extend the term of Mr. Bhonsles employment with us through December 31, 2013 at an annual salary of $300,000 for
the period of January 1, 2013 through December 31, 2013. The Bhonsle Agreement contains non-competition provisions applicable during the term of employment.



42



---

POTENTIAL PAYMENTS UPON TERMINATION OR CHANGE IN CONTROL

Pursuant to the Rubin Agreement and the Bhonsle Agreement, assuming a change of control had taken place as of December 31, 2012,
Dr. Rubin and Mr. Bhonsle would have been entitled to accelerated vesting of their outstanding stock options described in the table below:



|                 |  |                                                                        |      |  |                                                                   |                                                    
|---------------- |  | ---------------------------------------------------------------------- | ---- |  | ----------------------------------------------------------------- | ---------------------------------------------------
|                 |  | Value of Equity 
Awards:Termination WithoutCause or For Good Reason(1) |      |  | Value of Equity Awards:
In Connection With a Change in Control(1)
|Marc Rubin, M.D. |  |                                                                        | None |  |                                                                   | Fully Vested. 103,125 options with value of $16,408
|Sunil Bhonsle.   |  |                                                                        | None |  |                                                                   | Fully Vested. 88,019 options with value of $11,486 



|(1) | Value is based on the aggregate difference between the respective exercise prices and the closing sale price of our common stock on December 31, 2012, which was
$1.10 per share.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



43



---

DIRECTOR COMPENSATION

Summary of Director Compensation

Non-employee directors are entitled to
receive a fee for each meeting attended and all directors are entitled to receive stock options pursuant to our stockholder-approved stock option plans, including an initial grant of 10,000 options upon becoming a director, an annual grant of 20,000
options thereafter, and an annual grant of 5,000 options for each committee on which they serve. Directors are not precluded from serving us in any other capacity and receiving compensation therefor. Non-employee directors have also historically
received an annual retainer fee of $15,000 in addition to the fee received for each meeting attended. Non-employee directors receive $500 for each telephonic board meeting attended.

The following table summarizes compensation that our directors earned during 2012 for services as members of our board.



|                           |  |                              |        |  |                 |   |   |                   |  |   |                                         |  |  |                                                                       |   |  |                          |   |   |           |  |   |   |  |  |   |        | 
|-------------------------- |  | ---------------------------- | ------ |  | --------------- | - | - | ----------------- |  | - | --------------------------------------- |  |  | --------------------------------------------------------------------- | - |  | ------------------------ | - | - | --------- |  | - | - |  |  | - | ------ | 
|Name                       |  | FeesEarned orPaid inCash ($) |        |  | StockAwards ($) |   |   | OptionsAwards ($) |  |   | Non-EquityIncentive PlanCompensation($) |  |  | Change inPension ValueandNonqualifiedDeferredCompensationEarnings
($) |   |  | All OtherCompensation($) |   |   | Total ($) | 
|Victor J. Bauer, Ph.D.     |  | $                            | 29,500 |  |                 | $ |  |                   |  | $ | 32,889                                  |  |  | $                                                                     |  |  |                          | $ |  |           |  | $ |  |  |  | $ | 62,389 | 
|Eurelio M. Cavalier        |  |                              | 29,000 |  |                 |   |  |                   |  |   | 38,370                                  |  |  |                                                                       |  |  |                          |   |  |           |  |   |  |  |  |   | 67,370 | 
|Hubert E. Huckel, M.D.     |  |                              | 29,500 |  |                 |   |  |                   |  |   | 38,370                                  |  |  |                                                                       |  |  |                          |   |  |           |  |   |  |  |  |   | 67,870 | 
|M. David MacFarlane, Ph.D. |  |                              | 29,500 |  |                 |   |  |                   |  |   | 32,889                                  |  |  |                                                                       |  |  |                          |   |  |           |  |   |  |  |  |   | 62,389 | 
|Ley S. Smith               |  |                              | 29,500 |  |                 |   |  |                   |  |   | 38,370                                  |  |  |                                                                       |  |  |                          |   |  |           |  |   |  |  |  |   | 67,870 | 



|Item 12. | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.
|-------- | -----------------------------------------------------------------------------------------------

The following table sets forth, as of March 11, 2013, certain information concerning the beneficial ownership of our common stock by
(i) each stockholder known by us to own beneficially five percent or more of our outstanding common stock; (ii) each director; (iii) each named executive officer; and (iv) all of our executive officers and directors as a group,
and their percentage ownership and voting power.



|                                                            |  |                            |           |      |                                    |  |     |  
|----------------------------------------------------------- |  | -------------------------- | --------- | ---- | ---------------------------------- |  | --- | -
|Name and Address of Beneficial Owner(1)                     |  | SharesBeneficiallyOwned(2) |           |      | Percent of SharesBeneficiallyOwned | 
|Marc Rubin, M.D.                                            |  |                            | 2,376,575 | (3)  |                                    |  | 2.8 | %
|Victor J. Bauer, Ph.D.                                      |  |                            | 286,144   | (4)  |                                    |  | *   |  
|Sunil Bhonsle                                               |  |                            | 1,968,373 | (5)  |                                    |  | 2.4 | %
|Eurelio M. Cavalier                                         |  |                            | 437,500   | (6)  |                                    |  | *   |  
|Hubert E. Huckel, M.D.                                      |  |                            | 449,835   | (7)  |                                    |  | *   |  
|M. David MacFarlane, Ph.D.                                  |  |                            | 317,500   | (8)  |                                    |  | *   |  
|Ley S. Smith                                                |  |                            | 367,500   | (9)  |                                    |  | *   |  
|First Eagle Investment Management, LLC                      |  |                            | 7,446,205 | (10) |                                    |  | 9.1 | %
|All executive officers and directors as a group (7) persons |  |                            | 6,203,427 |      |                                    |  | 7.2 | %



|* | Less than one percent.
|- | ----------------------

|(1) | Unless otherwise indicated, the address of such individual is c/o Titan Pharmaceuticals, Inc., 400 Oyster Point Boulevard, Suite 505, South San Francisco, California
94080.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | In computing the number of shares beneficially owned by a person and the percentage ownership of a person, shares of our common stock subject to
options held by that person that are currently exercisable or exercisable within 60 days of March 11, 2013 are deemed outstanding. Such shares, however, are not deemed outstanding for purposes of computing the percentage ownership of each other
person. Except as
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



44



---

| | indicated in the footnotes to this table and pursuant to applicable community property laws, the persons named in the table have sole voting and investment power with respect to all shares of
common stock.
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Includes 1,844,375 shares issuable upon exercise of outstanding options.
|--- | ------------------------------------------------------------------------

|(4) | Includes 250,000 shares issuable upon exercise of outstanding options.
|--- | ----------------------------------------------------------------------

|(5) | Includes (i) 1,602,116 shares issuable upon exercise of outstanding options and (ii) 300,757 shares held in a family trust for which he serves as trustee.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Includes 255,000 shares issuable upon exercise of outstanding options.
|--- | ----------------------------------------------------------------------

|(7) | Includes (i) 265,000 shares issuable upon exercise of outstanding options and (ii) 789 shares held by his wife.
|--- | ---------------------------------------------------------------------------------------------------------------

|(8) | Includes 195,000 shares issuable upon exercise of outstanding options.
|--- | ----------------------------------------------------------------------

|(9) | Includes 255,000 shares issuable upon exercise of outstanding options.
|--- | ----------------------------------------------------------------------

|(10) | Derived from a Schedule 13G/A filed by First Eagle Investment Management, LLC on February 11, 2013. Includes warrants to purchase 1,562,500 shares of common stock.
The holders address is 1345 Avenue of the Americas, New York, New York 10105.
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Equity Compensation Plan
Information

The following table sets forth aggregate information regarding our equity compensation plans in effect as of
December 31, 2012:



|                                                                    |  |                                                                                            |           |  |                                                                          |   |      |                                                                                             |  |  |   | 
|------------------------------------------------------------------- |  | ------------------------------------------------------------------------------------------ | --------- |  | ------------------------------------------------------------------------ | - | ---- | ------------------------------------------------------------------------------------------- |  |  | - | 
|Plan category                                                       |  | Number of securities tobe issued upon exerciseof outstanding
options,warrant and rights(a) |           |  | Weighted-averageexerciseprice ofoutstandingoptions,warrantsand
rights(b) |   |      | Number of securitiesremaining available forfuture issuance underequity
compensationplans(c) | 
|Equity compensation plans approved by security holders              |  |                                                                                            | 4,280,153 |  |                                                                          | $ | 1.35 |                                                                                             |  |  |  | 
|Equity compensation plans not approved by security holders(1)(2)(3) |  |                                                                                            | 2,562,000 |  |                                                                          | $ | 1.34 |                                                                                             |  |  |  | 
|                                                                    |  |                                                                                            |           |  |                                                                          |   |      |                                                                                             |  |  |   | 
|Total                                                               |  |                                                                                            | 6,842,153 |  |                                                                          | $ | 1.35 |                                                                                             |  |  |  | 
|                                                                    |  |                                                                                            |           |  |                                                                          |   |      |                                                                                             |  |  |   | 



|(1) | In August 2002, we amended our 2001 Employee Non-Qualified Stock Option Plan. Pursuant to this amendment, a total of 1,750,000 shares of common stock were reserved and
authorized for issuance for option grants to employees and consultants who are not officers or directors of Titan. At December 31, 2012, 1,199,500 of these non-qualified stock options remained outstanding.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | In October 2007, we granted 1,500,000 non-qualified stock options outside of our stock option plans to our Chief Executive Officer, at an exercise price of $2.40,
vesting equally over 48 months from the date of grant. At December 31, 2012, 437,500 of these non-qualified stock options remained outstanding.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | In May 2009, we granted 615,000 and 310,000 non-qualified stock options outside of our stock option plans to our Executive Chairman and President, respectively, at an
exercise price of $0.79, vesting equally over 48 months from the date of grant.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



45



---

|Item 13. | Certain Relationships and Related Transactions, and Director Independence
|-------- | -------------------------------------------------------------------------

The following members of our board of directors, representing a majority of our board, meet the independence requirements and standards currently established by the NYSE MKT: Victor J. Bauer,
Eurelio M. Cavalier, Hubert E. Huckel, M. David MacFarlane and Ley S. Smith.

Certain Relationships and
Related Transactions. None.

Director Independence. The following members of our Board of Directors meet the
independence requirements and standards currently established by the NYSE MKT: Victor J. Bauer, Eurelio M. Cavalier, Hubert E. Huckel, M. David MacFarlane, and Ley S. Smith.

During the fiscal year ended December 31, 2012, the Board of Directors met nine times and no director attended fewer than 75% of the meetings of the Board of Directors and Board of Directors
committees of which the director was a member.

Compensation Committee. The Compensation Committee makes
recommendations to the Board of Directors concerning salaries and incentive compensation for our officers, including our Chief Executive Officer, and employees and administers our stock option plans. The Compensation Committee consists of
Eurelio M. Cavalier, Hubert E. Huckel and Victor J. Bauer, each of whom meets the independence requirements and standards currently established by the NYSE MKT. The Compensation Committee did not meet or take action by written consent
during the fiscal year ended December 31, 2012.

Nominating Committee. The purpose of the Nominating Committee is
to assist the Board of Directors in identifying qualified individuals to become board members, in determining the composition of the Board of Directors and in monitoring the process to assess Board effectiveness. The Nominating Committee consists of
Eurelio M. Cavalier, M. David MacFarlane and Ley S. Smith, each of whom meets the independence requirements and standards currently established by the NYSE MKT. The Nominating Committee did not meet or take action by written consent during the
fiscal year ended December 31, 2012.

Audit Committee. The Audit Committee (which is formed in compliance with
Section 3(a)(58)(A) of the Securities Exchange Act of 1934) consists of Ley S. Smith, M. David MacFarlane, Victor J. Bauer and Hubert E. Huckel, each of whom meets the independence requirements and standards currently established by
the NYSE MKT and the SEC. In addition, the Board of Directors has determined that Mr. Ley S. Smith is an audit committee financial expert and independent as defined under the relevant rules of the SEC and the NYSE MKT.
The Audit Committee assists the Board by overseeing the performance of the independent auditors and the quality and integrity of Titans internal accounting, auditing and financial reporting practices. The Audit Committee is responsible for
retaining (subject to stockholder ratification) and, as necessary, terminating, the independent auditors, annually reviews the qualifications, performance and independence of the independent auditors and the audit plan, fees and audit results, and
pre-approves audit and non-audit services to be performed by the auditors and related fees. During the fiscal year ended December 31, 2012, the Audit Committee met four times.



|Item 14. | Principal Accounting Fees and Services.
|-------- | ---------------------------------------

Aggregate fees billed by OUM & Co. LLP, an independent registered public accounting firm, during the fiscal years ended December 31, 2012 and 2011 were as follows:



|                   |  |      |         |  |      |   |         | 
|------------------ |  | ---- | ------- |  | ---- | - | ------- | 
|                   |  | 2012 |         |  | 2011 |  
|Audit Fees         |  | $    | 177,000 |  |      | $ | 142,000 | 
|Audit-Related Fees |  |      | 50,000  |  |      |   | 51,400  | 
|Tax Fees           |  |      | 36,395  |  |      |   | 39,835  | 
|All Other Fees     |  |      |        |  |      |   |        | 
|                   |  |      |         |  |      |   |         | 
|Total              |  | $    | 263,395 |  |      | $ | 233,235 | 
|                   |  |      |         |  |      |   |         | 



46



---

Audit FeesThis category includes aggregate fees billed by our independent
auditors for the audit of our annual financial statements, audit of managements assessment and effectiveness of internal controls over financial reporting, review of financial statements included in our quarterly reports on Form 10-Q and
services that are normally provided by the auditor in connection with statutory and regulatory filings for those fiscal years.

Audit-Related FeesThis category consists of services by our independent auditors that, including accounting consultations on
transaction related matters, are reasonably related to the performance of the audit or review of our financial statements and are not reported above under Audit Fees.

Tax FeesThis category consists of professional services rendered for tax compliance and preparation of our corporate tax returns and other tax advice.

All Other FeesDuring the years ended December 31, 2012 and 2011, OUM & Co. LLP did not incur any fees for
other professional services.

The Audit Committee reviewed and approved all audit and non-audit services provided by
OUM & Co. LLP and concluded that these services were compatible with maintaining its independence. The Audit Committee approved the provision of all non-audit services by OUM & Co. LLP. Of the total number of hours expended during
OUM & Co. LLPs engagement to audit the Companys financial statements for the year ended December 31, 2012, none of the hours were attributed to work performed by persons other than permanent, full-time employees of
OUM & Co. LLP.

Pre-Approval Policies and Procedures

In accordance with the SECs auditor independence rules, the Audit Committee has established the following policies and procedures by
which it approves in advance any audit or permissible non-audit services to be provided to us by our independent auditor.

Prior to the engagement of the independent auditors for any fiscal years audit, management submits to the Audit Committee for
approval lists of recurring audit, audit-related, tax and other services expected to be provided by the independent auditors during that fiscal year. The Audit Committee adopts pre-approval schedules describing the recurring services that it has
pre-approved, and is informed on a timely basis, and in any event by the next scheduled meeting, of any such services rendered by the independent auditor and the related fees.

The fees for any services listed in a pre-approval schedule are budgeted, and the Audit Committee requires the independent auditor and management to report actual fees versus the budget periodically
throughout the year. The Audit Committee will require additional pre-approval if circumstances arise where it becomes necessary to engage the independent auditor for additional services above the amount of fees originally pre-approved. Any audit or
non-audit service not listed in a pre-approval schedule must be separately pre-approved by the Audit Committee on a case-by-case basis.

Every request to adopt or amend a pre-approval schedule or to provide services that are not listed in a pre-approval schedule must include a statement by the independent auditors as to whether, in their
view, the request is consistent with the SECs rules on auditor independence.

The Audit Committee will not grant
approval for:



| |  |  | any services prohibited by applicable law or by any rule or regulation of the SEC or other regulatory body applicable to us;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | provision by the independent auditors to us of strategic consulting services of the type typically provided by management consulting firms; or
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------



47



---

| |  |  | the retention of the independent auditors in connection with a transaction initially recommended by the independent auditors, the tax treatment of
which may not be clear under the Internal Revenue Code and related regulations and which it is reasonable to conclude will be subject to audit procedures during an audit of our financial statements.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Tax services proposed to be provided by the auditor to any director, officer or employee of Titan who is in an accounting role or
financial reporting oversight role must be approved by the Audit Committee on a case-by-case basis where such services are to be paid for by us, and the Audit Committee will be informed of any services to be provided to such individuals that are not
to be paid for by us.

In determining whether to grant pre-approval of any non-audit services in the all other
category, the Audit Committee will consider all relevant facts and circumstances, including the following four basic guidelines:



| |  |  | whether the service creates a mutual or conflicting interest between the auditor and us;
| | - |  | ----------------------------------------------------------------------------------------



| |  |  | whether the service places the auditor in the position of auditing his or her own work;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | whether the service results in the auditor acting as management or an employee of our company; and
| | - |  | --------------------------------------------------------------------------------------------------



| |  |  | whether the service places the auditor in a position of being an advocate for our company.
| | - |  | ------------------------------------------------------------------------------------------

PART IV



|Item 15. | Exhibits and Financial Statements Schedules.
|-------- | --------------------------------------------

(a)    1.    Financial Statements

An index to Consolidated Financial Statements appears on page F-1.

2.    Schedules

All financial statement schedules are omitted because they are not applicable, not required under the instructions or all the information required is set forth in the financial statements or notes
thereto.



48



---

TITAN PHARMACEUTICALS, INC.

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS



|                                                                                                                   |  |      |     | 
|------------------------------------------------------------------------------------------------------------------ |  | ---- | --- | 
|                                                                                                                   |  | Page |    
|Reports of Independent Registered Public Accounting Firm                                                           |  |      | F-2 | 
|Consolidated Balance Sheets as of December 31, 2012 and 2011                                                       |  |      | F-4 | 
|Consolidated Statements of Operations and Comprehensive Loss for the years ended December 
31, 2012, 2011 and 2010 |  |      | F-5 | 
|Consolidated Statements of Stockholders Deficit for the years ended December 
31, 2012, 2011 and 2010             |  |      | F-6 | 
|Consolidated Statements of Cash Flows for the years ended December 31, 2012, 2011 and
2010                         |  |      | F-7 | 
|Notes to Consolidated Financial Statements                                                                         |  |      | F-8 | 



F-1



---

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Board of Directors and Stockholders of

Titan Pharmaceuticals, Inc.

We have audited the accompanying consolidated
balance sheets of Titan Pharmaceuticals, Inc. as of December 31, 2012 and 2011, the related consolidated statements of operations and comprehensive loss, stockholders deficit and cash flows for each of the three years in the period ended
December 31, 2012. These financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those
standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit also includes examining, on a test basis, evidence supporting the amounts and
disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits
provide a reasonable basis for our opinion.

In our opinion, the consolidated financial statements audited by us present
fairly, in all material respects, the consolidated financial position of Titan Pharmaceuticals, Inc. at December 31, 2012 and 2011, and the consolidated results of its operations and its cash flows for each of the three years in the period
ended December 31, 2012, in conformity with U.S. generally accepted accounting principles.

We also have audited, in
accordance with the standards of the Public Company Accounting Oversight Board (United States), Titan Pharmaceuticals, Inc.s internal control over financial reporting as of December 31, 2012, based on criteria established in Internal
Control-Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated March 14, 2013 expressed an unqualified opinion thereon.

/s/ OUM & Co. LLP

San Francisco, California

March 14, 2013



F-2



---

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Board of Directors and Stockholders of

Titan Pharmaceuticals, Inc.

We
have audited Titan Pharmaceuticals, Inc.s internal control over financial reporting as of December 31, 2012, based on criteria established in Internal ControlIntegrated Framework issued by the Committee of Sponsoring
Organizations of the Treadway Commission (the COSO criteria). Titan Pharmaceuticals, Inc.s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal
control over financial reporting included in Managements Annual Report on Internal Control Over Financial Reporting included in Item 9A. Our responsibility is to express an opinion on the Companys internal control over financial
reporting based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting
Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included
obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing
such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

A companys internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial
statements for external purposes in accordance with U.S. generally accepted accounting principles. A companys internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records
that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements
in accordance with U.S. generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable
assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the companys assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections
of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

In our opinion, Titan Pharmaceuticals, Inc. maintained, in all material respects, effective internal control over financial reporting as
of December 31, 2012, based on the COSO criteria.

We also have audited, in accordance with the standards of the Public
Company Accounting Oversight Board (United States), the consolidated balance sheets of Titan Pharmaceuticals, Inc. as of December 31, 2012 and 2011, and the related consolidated statements of operations and comprehensive loss,
stockholders deficit, and cash flows for each of the three years in the period ended December 31, 2012, and our report dated March 14, 2013, expressed an unqualified opinion thereon.

/s/ OUM & Co. LLP

San Francisco,
California

March 14, 2013



F-3



---

TITAN PHARMACEUTICALS, INC.

CONSOLIDATED BALANCE SHEETS



|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------------------------------------- | -------- | - | ---- | - | -------- | -
|                                                                                                                                                                                                  |  | December 31,                                    |         
|                                                                                                                                                                                                  |  | 2012                                            |          |   | 2011 |  
|                                                                                                                                                                                                  |  | (in thousands, exceptshare and per share data ) |         
|Assets                                                                                                                                                                                            |  |                                                 |          |   |      |   |          |  
|Current assets:                                                                                                                                                                                   |  |                                                 |          |   |      |   |          |  
|Cash                                                                                                                                                                                              |  | $                                               | 18,102   |   |      | $ | 5,406    |  
|Receivables                                                                                                                                                                                       |  |                                                 | 4,646    |   |      |   | 3,720    |  
|Prepaid expenses and other current assets                                                                                                                                                         |  |                                                 | 687      |   |      |   | 836      |  
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|Total current assets                                                                                                                                                                              |  |                                                 | 23,435   |   |      |   | 9,962    |  
|Property and equipment, net                                                                                                                                                                       |  |                                                 | 1,392    |   |      |   | 255      |  
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|Total Assets                                                                                                                                                                                      |  | $                                               | 24,827   |   |      | $ | 10,217   |  
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|Liabilities and Stockholders Deficit                                                                                                                                                             |  |                                                 |          |   |      |   |          |  
|Current liabilities:                                                                                                                                                                              |  |                                                 |          |   |      |   |          |  
|Accounts payable                                                                                                                                                                                  |  | $                                               | 3,767    |   |      | $ | 4,789    |  
|Accrued clinical trials expenses                                                                                                                                                                  |  |                                                 | 532      |   |      |   | 161      |  
|Other accrued liabilities                                                                                                                                                                         |  |                                                 | 219      |   |      |   | 173      |  
|Deferred contract revenue                                                                                                                                                                         |  |                                                 | 14,375   |   |      |   |         |  
|Current portion of long-term debt                                                                                                                                                                 |  |                                                 | 2,500    |   |      |   |         |  
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|Total current liabilities                                                                                                                                                                         |  |                                                 | 21,393   |   |      |   | 5,123    |  
|Warrant liability                                                                                                                                                                                 |  |                                                 | 8,240    |   |      |   | 3,611    |  
|Royalty liability                                                                                                                                                                                 |  |                                                 | 8,962    |   |      |   | 9,309    |  
|Long-term debt, net of discount                                                                                                                                                                   |  |                                                 | 9,360    |   |      |   | 12,253   |  
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|Total Liabilities                                                                                                                                                                                 |  |                                                 | 47,955   |   |      |   | 30,296   |  
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|Commitments and contingencies                                                                                                                                                                     |  |                                                 |          |   |      |   |          |  
|                                                                                                                                                                                                  |  |                                                
|Stockholders deficit:                                                                                                                                                                            |  |                                                 |          |   |      |   |          |  
|Preferred stock, $0.001 par value per share; 5,000,000 shares authorized, none issued and outstanding:                                                                                            |  |                                                 |         |   |      |   |         |  
|Common stock, at amounts paid in, $0.001 par value per share; 125,000,000 shares authorized, 75,215,713 and 59,386,542 shares
issued and outstanding at December 31, 2012 and 2011, respectively. |  |                                                 | 265,986  |   |      |   | 256,436  |  
|Additional paid-in capital                                                                                                                                                                        |  |                                                 | 21,014   |   |      |   | 18,433   |  
|Accumulated deficit                                                                                                                                                                               |  |                                                 | (310,128 | ) |      |   | (294,948 | )
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|Total stockholders deficit                                                                                                                                                                       |  |                                                 | (23,128  | ) |      |   | (20,079  | )
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  
|Total Liabilities and Stockholders Deficit                                                                                                                                                       |  | $                                               | 24,827   |   |      | $ | 10,217   |  
|                                                                                                                                                                                                  |  |                                                 |          |   |      |   |          |  

See accompanying notes to consolidated financial statements.



F-4



---

TITAN PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS



|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|------------------------------------------------------------------------------------- |  | -------------------------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------ | -
|                                                                                      |  | Years ended December 31,               |        
|                                                                                      |  | 2012                                   |         |   | 2011 |   |         | 2010 | 
|                                                                                      |  | (in thousands, except per shareamount) |        
|Revenue:                                                                              |  |                                        |         |   |      |   |         |      |  |   |        |  
|Royalty revenue                                                                       |  | $                                      | 4,750   |   |      | $ | 3,585   |      |  | $ | 2,512  |  
|License revenue                                                                       |  |                                        | 2,325   |   |      |   |        |      |  |   | 24     |  
|Grant revenue                                                                         |  |                                        | 42      |   |      |   | 483     |      |  |   | 7,557  |  
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|Total revenue                                                                         |  |                                        | 7,117   |   |      |   | 4,068   |      |  |   | 10,093 |  
|Operating expenses:                                                                   |  |                                        |         |   |      |   |         |      |  |   |        |  
|Research and development                                                              |  |                                        | 10,610  |   |      |   | 11,206  |      |  |   | 12,855 |  
|General and administrative                                                            |  |                                        | 4,877   |   |      |   | 3,368   |      |  |   | 3,263  |  
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|Total operating expenses                                                              |  |                                        | 15,487  |   |      |   | 14,574  |      |  |   | 16,118 |  
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|Loss from operations                                                                  |  |                                        | (8,370  | ) |      |   | (10,506 | )    |  |   | (6,025 | )
|Other income (expense):                                                               |  |                                        |         |   |      |   |         |      |  |   |        |  
|Interest expense, net                                                                 |  |                                        | (4,861  | ) |      |   | (6,430  | )    |  |   | (678   | )
|Other expense, net                                                                    |  |                                        | (183    | ) |      |   | (129    | )    |  |   | (131   | )
|Non-cash gain (loss) on changes in the fair value of warrants                         |  |                                        | (1,766  | ) |      |   | 1,862   |      |  |   |       |  
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|Other expense, net                                                                    |  |                                        | (6,810  | ) |      |   | (4,697  | )    |  |   | (809   | )
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|Net loss and comprehensive loss                                                       |  |                                        | (15,180 | ) |      |   | (15,203 | )    |  |   | (6,834 | )
|Gain on retirement of preferred stock upon dissolution of subsidiary                  |  |                                        |        |   |      |   |        |      |  |   | 1,241  |  
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|Net loss applicable to common stockholders                                            |  | $                                      | (15,180 | ) |      | $ | (15,203 | )    |  | $ | (5,593 | )
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|Basic and diluted net loss per common share                                           |  | $                                      | (0.23   | ) |      | $ | (0.26   | )    |  | $ | (0.09  | )
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  
|Weighted average shares used in computing basic and diluted net loss per common share |  |                                        | 66,509  |   |      |   | 59,324  |      |  |   | 59,248 |  
|                                                                                      |  |                                        |         |   |      |   |         |      |  |   |        |  

See accompanying notes to consolidated financial statements.



F-5



---

TITAN PHARMACEUTICALS, INC

CONSOLIDATED STATEMENTS OF STOCKHOLDERS DEFICIT

(in thousands)



|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|--------------------------------------------------------------------- |  | ------------ | ------ |  | ------------------------ | - | ------- | ------------------ |  | - | ------------------------------------------ |  |  | ------------------------- | -------- | - |  | - | - |  |  | - | ------- | -
|                                                                      |  | Common Stock |        |  | AdditionalPaid-InCapital |   |         | AccumulatedDeficit |  |   | AccumulatedOtherComprehensiveIncome (Loss) |  |  | TotalStockholdersDeficit |         
|                                                                      |  | Shares       |        |  | Amount                   |   |         |                    |  |  
|Balances at December 31, 2009                                         |  |              | 59,248 |  |                          | $ | 256,436 |                    |  | $ | 15,027                                     |  |  | $                         | (272,911 | ) |  | $ |  |  |  | $ | (1,448  | )
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Comprehensive loss:                                                   |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Net loss                                                              |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           | (6,834   | ) |  |   |   |  |  |   | (6,834  | )
|Unrealized gain or loss on marketable securities                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |        |  
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Comprehensive loss                                                    |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   | (6,834  | )
|Retirement of preferred stock upon dissolution of Ingenex, Inc.       |  |              |        |  |                          |   |         |                    |  |   | 1,241                                      |  |  |                           |          |   |  |   |   |  |  |   | 1,241   |  
|Issuance of warrants to purchase common stock                         |  |              |        |  |                          |   |         |                    |  |   | 255                                        |  |  |                           |          |   |  |   |   |  |  |   | 255     |  
|Compensation related to stock options                                 |  |              |        |  |                          |   |         |                    |  |   | 733                                        |  |  |                           |          |   |  |   |   |  |  |   | 733     |  
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Balances at December 31, 2010                                         |  |              | 59,248 |  |                          |   | 256,436 |                    |  |   | 17,256                                     |  |  |                           | (279,745 | ) |  |   |  |  |  |   | (6,053  | )
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Comprehensive loss:                                                   |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Net loss                                                              |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           | (15,203  | ) |  |   |   |  |  |   | (15,203 | )
|Unrealized gain or loss on marketable securities                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |        |  
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Comprehensive loss                                                    |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   | (15,203 | )
|Issuance of common stock upon vesting of restricted stock awards      |  |              | 139    |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |        |  
|Compensation related to stock options                                 |  |              |        |  |                          |   |         |                    |  |   | 1,177                                      |  |  |                           |          |   |  |   |   |  |  |   | 1,177   |  
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Balances at December 31, 2011                                         |  |              | 59,387 |  |                          |   | 256,436 |                    |  |   | 18,433                                     |  |  |                           | (294,948 | ) |  |   |  |  |  |   | (20,079 | )
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Comprehensive loss:                                                   |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Net loss                                                              |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           | (15,180  | ) |  |   |   |  |  |   | (15,180 | )
|Unrealized gain or loss on marketable securities                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |        |  
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Comprehensive loss                                                    |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   | (15,180 | )
|Issuance of common stock, net of issuance costs                       |  |              | 9,917  |  |                          |   | 4,653   |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   | 4,653   |  
|Issuance of common stock upon exercise of warrants                    |  |              | 5,762  |  |                          |   | 4,897   |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   | 4,897   |  
|Issuance of common stock upon vesting of restricted stock awards, net |  |              | 150    |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |        |  
|Compensation related to stock options                                 |  |              |        |  |                          |   |         |                    |  |   | 2,581                                      |  |  |                           |          |   |  |   |   |  |  |   | 2,581   |  
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  
|Balances at December 31, 2012                                         |  |              | 75,216 |  |                          | $ | 265,986 |                    |  | $ | 21,014                                     |  |  | $                         | (310,128 | ) |  | $ |  |  |  | $ | (23,128 | )
|                                                                      |  |              |        |  |                          |   |         |                    |  |   |                                            |  |  |                           |          |   |  |   |   |  |  |   |         |  

See accompanying notes to consolidated financial statements.



F-6



---

TITAN PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS



|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|--------------------------------------------------------------------------- |  | ------------------------ | ------- | - | ---- | - | ------- | ---- |  | - | ------ | -
|                                                                            |  | Years ended December 31, |        
|                                                                            |  | 2012                     |         |   | 2011 |   |         | 2010 | 
|                                                                            |  | (in thousands)           |        
|Cash flows from operating activities:                                       |  |                          |         |   |      |   |         |      |  |   |        |  
|Net loss                                                                    |  | $                        | (15,180 | ) |      | $ | (15,203 | )    |  | $ | (6,834 | )
|Adjustments to reconcile net loss to net cash used in operating activities: |  |                          |         |   |      |   |         |      |  |   |        |  
|Depreciation and amortization                                               |  |                          | 17      |   |      |   | 32      |      |  |   | 85     |  
|Amortization of discount on long-term debt                                  |  |                          |        |   |      |   | 1,520   |      |  |   | 132    |  
|Interest on royalty liability                                               |  |                          | (347    | ) |      |   | 1,309   |      |  |   |       |  
|Non-cash (gain) loss on changes in fair value of warrants                   |  |                          | 1,766   |   |      |   | (1,862  | )    |  |   |       |  
|Stock-based compensation                                                    |  |                          | 2,581   |   |      |   | 1,177   |      |  |   | 733    |  
|Changes in operating assets and liabilities:                                |  |                          |         |   |      |   |         |      |  |   |        |  
|Receivables                                                                 |  |                          | (926    | ) |      |   | (2,495  | )    |  |   | (1,159 | )
|Prepaid expenses and other assets                                           |  |                          | 149     |   |      |   | (542    | )    |  |   | (44    | )
|Accounts payable                                                            |  |                          | (1,022  | ) |      |   | 2,332   |      |  |   | 2,122  |  
|Other accrued liabilities                                                   |  |                          | 417     |   |      |   | (744    | )    |  |   | 308    |  
|Deferred contract revenue                                                   |  |                          | 14,375  |   |      |   |        |      |  |   |       |  
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Net cash provided by (used in) operating activities                         |  |                          | 1,830   |   |      |   | (14,476 | )    |  |   | (4,657 | )
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Cash flows from investing activities:                                       |  |                          |         |   |      |   |         |      |  |   |        |  
|Purchases of furniture and equipment                                        |  |                          | (1,154  | ) |      |   | (236    | )    |  |   | (28    | )
|Disposals of furniture and equipment                                        |  |                          |        |   |      |   | 2       |      |  |   |       |  
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Net cash used in investing activities                                       |  |                          | (1,154  | ) |      |   | (234    | )    |  |   | (28    | )
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Cash flows from financing activities:                                       |  |                          |         |   |      |   |         |      |  |   |        |  
|Proceeds from issuance of common stock and warrants, net of issuance costs  |  |                          | 7,516   |   |      |   |        |      |  |   |       |  
|Proceeds from the exercise of warrants, net of issuance costs               |  |                          | 4,897   |   |      |   |        |      |  |   |       |  
|Proceeds from royalty financing                                             |  |                          |        |   |      |   | 8,000   |      |  |   |       |  
|Proceeds from long-term debt, net                                           |  |                          |        |   |      |   | 16,500  |      |  |   | 5,000  |  
|Payments on long-term debt                                                  |  |                          | (393    | ) |      |   | (7,564  | )    |  |   | (435   | )
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Net cash provided by financing activities                                   |  |                          | 12,020  |   |      |   | 16,936  |      |  |   | 4,565  |  
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Net increase (decrease) in cash                                             |  |                          | 12,696  |   |      |   | 2,226   |      |  |   | (120   | )
|Cash at beginning of period                                                 |  |                          | 5,406   |   |      |   | 3,180   |      |  |   | 3,300  |  
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Cash at end of period                                                       |  | $                        | 18,102  |   |      | $ | 5,406   |      |  | $ | 3,180  |  
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Supplemental disclosure of cash flow information                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Interest paid                                                               |  | $                        | 2,576   |   |      | $ | 1,652   |      |  | $ | 678    |  
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  
|Schedule of non-cash transactions                                           |  |                          |         |   |      |   |         |      |  |   |        |  
|Retirement of preferred stock upon dissolution of Ingenex, Inc.             |  | $                        |        |   |      | $ |        |      |  | $ | 1,241  |  
|                                                                            |  |                          |         |   |      |   |         |      |  |   |        |  

See accompanying notes to consolidated financial statements.



F-7



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1. Organization and Summary of Significant Accounting Policies

The Company and its Subsidiaries

We are a biopharmaceutical company developing proprietary therapeutics for the treatment of serious medical disorders. Our product
development programs focus primarily on important pharmaceutical markets with significant unmet medical needs and commercial potential. We are directly developing our product candidates and also utilize corporate, academic and government
partnerships as appropriate. Such collaborations have helped to fund product development and have enabled us to retain significant economic interest in our products. We operate in only one business segment, the development of pharmaceutical
products.

Our principal asset is Probuphine®, the first slow release implant formulation of buprenorphine, designed to maintain a stable, round the clock blood level of the medicine in patients for six months
following a single treatment. An NDA seeking approval of Probuphine for the treatment of opioid dependence in adult patients has been accepted by the FDA for a Priority Review. Based upon the Prescription Drug User Fee Act (PDUFA), the FDA has set a
target date of April 30, 2013 for FDA action on the NDA.

In December 2012, we entered into a license agreement with
Braeburn Pharmaceuticals Sprl that grants Braeburn exclusive commercialization rights to Probuphine in the United States and Canada. We received a non-refundable up-front license fee of $15.75 million (approximately $15.0 million, net of expenses)
and will receive a $50 million milestone payment upon approval by the FDA of the NDA. Additionally, we will be eligible to receive up to $130 million upon achievement of specified sales milestones and up to $35 million in regulatory milestones for
additional indications, including chronic pain. We will receive tiered royalties on net sales of Probuphine ranging from the mid-teens to the low twenties. In addition to the potential milestone payments, Apple Tree Partners IV, Braeburns
parent company, has allocated in excess of $75 million to launch, commercialize and continue the development of Probuphine.

The accompanying financial statements have been prepared assuming we will continue as a going concern. We believe that our working
capital at December 31, 2012, together with the FDAs reimbursement of the NDA filing fee, is sufficient to fund our planned operations through June 2014. In the event that the FDA issues a complete response letter requiring us to conduct
additional clinical studies that would require expenditures in excess of certain amounts specified in our agreement with Braeburn, Braeburn will have the right to either terminate the agreement or reduce the amount of the $50 million milestone
payment payble to us in the event the FDA ultimately approves of Probuphine. If Braeburn were to terminate the agreement, we would not have sufficient funds available to us to complete the FDA approval process and commercialize Probuphine and, as a
result, our business and prospects will be materially adversely impacted. Furthermore, continuation of our current Parkinsons disease development program and the initiation of any additional programs will depend upon our receipt of the $50
million milestone payment and if such payment is not received or is significantly reduced our ability to fund any new product development programs will be materially impaired and we may need to obtain additional financing, either through the sale of
debt or equity securities, to continue our Probuphine program and other product development activities. If we are unable to complete a debt or equity offering, or otherwise obtain sufficient financing when and if needed, we may be required to
reduce, defer or discontinue one or more of our product development activities.

Basis of Presentation and Consolidation

The accompanying consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the
United States and include the accounts of Titan Pharmaceuticals, Inc. and its former majority-owned subsidiary. All significant intercompany balances and transactions are eliminated.



F-8



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires
management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates.

Stock-Based Compensation

We recognize compensation expense using a fair-value based method, for all stock-based payments including stock options and restricted
stock awards and stock issued under an employee stock purchase plan. These standards require companies to estimate the fair value of stock-based payment awards on the date of grant using an option pricing model. See Note 12 Stock Plans,
for a discussion of our stock-based compensation plans. Our non-cash stock-based compensation expense related to employees and non-employee members of our board of directors totaled $2.6 million, $1.2 million and $0.7 million for the years ended
December 31, 2012, 2011 and 2010, respectively.

Warrants Issued in Connection with Equity Financing

We generally account for warrants issued in connection with equity financings as a component of equity, unless there
is a deemed possibility that we may have to settle warrants in cash. For warrants issued with deemed possibility of cash settlement, we record the fair value of the issued warrants as a liability at each reporting period and record changes in the
estimated fair value as a non-cash gain or loss in the Consolidated Statements of Operations and Comprehensive Loss.

Cash, Cash Equivalents and Marketable Securities

Our investment policy emphasizes liquidity and preservation of principal over other portfolio considerations. We
select investments that maximize interest income to the extent possible given these two constraints. We satisfy liquidity requirements by investing excess cash in securities with different maturities to match projected cash needs and limit
concentration of credit risk by diversifying our investments among a variety of high credit-quality issuers and limit the amount of credit exposure to any one issuer. The estimated fair values have been determined using available market information.
We do not use derivative financial instruments in our investment portfolio.

All investments with original maturities of three
months or less are considered to be cash equivalents. Our marketable securities, consisting primarily of high-grade debt securities including money market funds, U.S. government and corporate notes and bonds, and commercial paper, are classified as
available-for-sale at time of purchase and carried at fair value. If the fair value of a security is below its amortized cost and we plan to sell the security before recovering its cost, the impairment is considered to be other-than-temporary.
Other-than-temporary declines in fair value of our marketable securities are charged against interest income. We did not have cash equivalents or marketable securities as of December 31, 2012 and 2011 and for any of the periods presented.

Property and Equipment

Property and equipment are recorded at cost and depreciated using the straight-line method over the estimated useful lives of the assets
ranging from three to five years. Leasehold improvements are amortized over the shorter of the lease term or the estimated useful life of the assets.



F-9



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Revenue Recognition

We generate revenue principally from collaborative research and development arrangements, technology licenses, and government grants.
Consideration received for revenue arrangements with multiple components is allocated among the separate units of accounting based on their respective selling prices. The selling price for each unit is based on vendor-specific objective evidence, or
VSOE, if available, third party evidence if VSOE is not available, or estimated selling price if neither VSOE nor third party evidence is available. The applicable revenue recognition criteria are then applied to each of the units.

Revenue is recognized when the four basic criteria of revenue recognition are met: (1) a contractual agreement exists;
(2) transfer of technology has been completed or services have been rendered; (3) the fee is fixed or determinable; and (4) collectibility is reasonably assured. For each source of revenue, we comply with the above revenue recognition
criteria in the following manner:



| |  |  | Collaborative arrangements typically consist of non-refundable and/or exclusive technology access fees, cost reimbursements for specific research and
development spending, and various milestone and future product royalty payments. If the delivered technology does not have stand-alone value, the amount of revenue allocable to the delivered technology is deferred. Non-refundable upfront fees with
stand-alone value that are not dependent on future performance under these agreements are recognized as revenue when received, and are deferred if we have continuing performance obligations and have no evidence of fair value of those obligations.
Cost reimbursements for research and development spending are recognized when the related costs are incurred and when collectability is reasonably assured. Payments received related to substantive, performance-based at-risk milestones
are recognized as revenue upon achievement of the clinical success or regulatory event specified in the underlying contracts, which represent the culmination of the earnings process. Amounts received in advance are recorded as deferred revenue until
the technology is transferred, costs are incurred, or a milestone is reached.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Technology license agreements typically consist of non-refundable upfront license fees, annual minimum access fees or royalty payments. Non-refundable
upfront license fees and annual minimum payments received with separable stand-alone values are recognized when the technology is transferred or accessed, provided that the technology transferred or accessed is not dependent on the outcome of our
continuing research and development efforts.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Government grants, which support our research efforts in specific projects, generally provide for reimbursement of approved costs as defined in the
notices of grants. Grant revenue is recognized when associated project costs are incurred.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Royalties earned are based on third-party sales of licensed products and are recorded in accordance with contract terms when third-party results are
reliably measurable and collectibility is reasonably assured. Pursuant to certain license agreements, we earn royalties on the sale of Fanapt by Novartis in the U.S. As described in Note 7, Commitments and Contingencies, we are obligated
to pay royalties on such sales to Sanofi-Aventis and another third party. As we have no performance obligations under the license agreements, we have recorded the royalties earned, net of royalties we are obligated to pay, as revenue in our
consolidated statement of operations.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Research and Development Costs and Related Accrual

Research and development expenses include internal and external costs. Internal costs include salaries and employment
related expenses, facility costs, administrative expenses and allocations of corporate costs. External expenses consist of costs associated with outsourced clinical research organization activities, sponsored research studies, product registration,
patent application and prosecution, and investigator sponsored trials. We also record



F-10



---

TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



accruals for estimated ongoing clinical trial costs. Clinical trial costs represent costs incurred by CROs, and clinical sites. These costs are recorded as a component of research &
development expenses. Under our agreements, progress payments are typically made to investigators, clinical sites and CROs. We analyze the progress of the clinical trials, including levels of patient enrollment, invoices received and contracted
costs when evaluating the adequacy of accrued liabilities. Significant judgments and estimates must be made and used in determining the accrued balance in any accounting period. Actual results could differ from those estimates under different
assumptions. Revisions are charged to expense in the period in which the facts that give rise to the revision become known.

Net Loss Per Share

We calculate basic net loss per share using the weighted average common shares outstanding for the period. Diluted net income per share
would include the impact of other dilutive equity instruments, primarily our options and warrants. For the years ended December 31, 2012, 2011 and 2010, options and warrants totaled 19.7 million, 18.6 million and 12.1 million
shares, respectively. We reported net losses for all years presented and, therefore, options and warrants were excluded from the calculation of diluted net loss per share as they were anti-dilutive.

Comprehensive Income (Loss)

Comprehensive income (loss) is comprised of net loss and other comprehensive income (loss). We had no unrealized gains or losses at
December 31, 2012 and 2011. Comprehensive loss for the years ended December 31, 2012, 2011 and 2010 was $15.2 million, $15.2 million and $6.8 million, respectively.

Recent Accounting Pronouncements

In June 2011, the FASB issued Accounting Standards Update (ASU) No. 2011-05 Presentation of Comprehensive Income
that improves the comparability, consistency, and transparency of financial reporting and increases the prominence of items reported in other comprehensive income by eliminating the option to present components of other comprehensive income as part
of the statement of changes in stockholders equity. The amendments in this standard require that all non-owner changes in stockholders equity be presented either in a single continuous statement of comprehensive income or in two separate
but consecutive statements. Under either method, adjustments must be displayed for items that are reclassified from other comprehensive income (OCI) to net income, in both net income and OCI. The standard does not change the current
option for presenting components of OCI gross or net of the effect of income taxes, provided that such tax effects are presented in the statement in which OCI is presented or disclosed in the notes to the financial statements. Additionally, the
standard does not affect the calculation or reporting of earnings per share. For public entities, the amendments in this ASU are effective for fiscal years, and interim periods within those years, beginning after December 15, 2011 and are to be
applied retrospectively, with early adoption permitted. In December 2011, the FASB issued ASU No. 2011-12 to defer the effective date of certain amendments to the presentation of reclassifications of items out of the accumulated other
comprehensive income in ASU No 2011-05 to allow the FASB time to redeliberate on the matter. ASU No. 2011-12 is effective at the same time as the amendments in ASU No. 2011-05. The adoption of this standard did not have a material impact
on our consolidated financial statements.



F-11



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



In May 2011, the FASB issued ASU No. 2011-04 which amends GAAP to conform to the
measurement and disclosure requirements in International Financial Reporting Standards (IFRS). The amendments in this ASU change the wording used to describe the requirements in U.S. GAAP for measuring fair value and for disclosing
information about fair value measurements. The amendments include the following:



| |  |  | Those that clarify the FASBs intent regarding the application of existing fair value measurement and disclosure requirements; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | Those that change a particular principle or requirement for measuring fair value or for disclosing information about fair value measurements.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------

In addition, to improve consistency in application across jurisdictions some changes in wording are
necessary to ensure that GAAP and IFRS fair value measurement and disclosure requirements are described in the same way (for example, using the word shall rather than should to describe the requirements in GAAP). The amendments in this ASU are to be
applied prospectively and are effective during interim and annual periods beginning after December 15, 2011. We will evaluate the requirements and do not believe that the adoption of this update will have a material impact on our consolidated
financial statements at this time.

Subsequent Events

We have evaluated events that have occurred subsequent to December 31, 2012 and through the date that the financial statements are
issued.

Fair Value Measurements

We measure the fair value of financial assets and liabilities based on authoritative guidance which defines fair value, establishes a
framework consisting of three levels for measuring fair value, and requires disclosures about fair value measurements. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in
the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. There are three levels of inputs that may be used to measure fair value:

Level 1  quoted prices in active markets for identical assets or liabilities

Level 2  quoted prices for similar assets and liabilities in active markets or inputs that are observable;

Level 3  inputs that are unobservable (for example cash flow modeling inputs based on assumptions).

Financial instruments, including cash, receivables, accounts payable and accrued liabilities are carried at cost, which we believe
approximates fair value due to the short-term nature of these instruments. Our warrant liabilities are classified within level 3 of the fair value hierarchy because the value is calculated using significant judgment based on our own assumptions in
the valuation of these liabilities.

During the years ended December 31, 2012 and 2011, as a result of the fair value
adjustment of the warrant liabilities, we recorded a non-cash loss on an increase in the fair value of $1,766,000 and a non-cash gain on a decrease in the fair value of $1,862,000, respectively, in our statements of operations and comprehensive
loss. See Note 9, Warrant Liabilities for further discussion on the calculation of the fair value of the warrant liabilities.



F-12



---

TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



The following table rolls forward the fair value of the Companys warrant
liabilities, the fair value of which is determined by Level 3 inputs for the years ended December 31, 2012 and 2011 (in thousands):



|                                |  |              |       |  |      |   |        |  
|------------------------------- |  | ------------ | ----- |  | ---- | - | ------ | -
|                                |  | December 31, |      
|                                |  | 2012         |       |  | 2011 |  
|Fair value, beginning of period |  | $            | 3,611 |  |      | $ |       |  
|Issuance of warrants            |  |              | 2,863 |  |      |   | 5,473  |  
|Change in fair value            |  |              | 1,766 |  |      |   | (1,862 | )
|                                |  |              |       |  |      |   |        |  
|Fair value, end of period       |  | $            | 8,240 |  |      | $ | 3,611  |  
|                                |  |              |       |  |      |   |        |  

2. Property and Equipment

Property and equipment consisted of the following at December 31, 2012 and 2011 (in thousands):



|                                               |  |      |        |   |      |   |        |  
|---------------------------------------------- |  | ---- | ------ | - | ---- | - | ------ | -
|                                               |  | 2012 |        |   | 2011 |  
|Furniture and office equipment                 |  | $    | 388    |   |      | $ | 388    |  
|Leasehold improvements                         |  |      | 408    |   |      |   | 408    |  
|Laboratory equipment                           |  |      | 2,047  |   |      |   | 922    |  
|Computer equipment                             |  |      | 996    |   |      |   | 967    |  
|                                               |  |      |        |   |      |   |        |  
|                                               |  |      | 3,839  |   |      |   | 2,685  |  
|Less accumulated depreciation and amortization |  |      | (2,447 | ) |      |   | (2,430 | )
|                                               |  |      |        |   |      |   |        |  
|Property and equipment, net                    |  | $    | 1,392  |   |      | $ | 255    |  
|                                               |  |      |        |   |      |   |        |  

Depreciation and amortization expense was $17,000, $32,000 and $85,000 for the years ended December 31, 2012, 2011
and 2010, respectively.

3. Research and License Agreements

We have entered into various agreements with research institutions, universities, clinical research organizations and
other entities for the performance of research and development activities and for the acquisition of licenses related to those activities. Expenses under these agreements totaled approximately $3,000, $36,000, and $61,000 in the years ended
December 31, 2012, 2011 and 2010, respectively.

We make no annual payments to maintain our current licenses after 2015.
Certain licenses provide for the payment of royalties by us on future product sales, if any. In addition, in order to maintain these licenses and other rights during product development, we must comply with various conditions including the payment
of patent-related costs.

4. Agreement with Sanofi-Aventis SA

In 1997, we entered into an exclusive license agreement with Sanofi-Aventis. The agreement gave us a worldwide license
to the patent rights and know-how related to the antipsychotic agent iloperidone, including the ability to develop, use, sublicense, manufacture and sell products and processes claimed in the patent rights. We are required to make additional
benchmark payments as specific milestones are met. Upon commercialization of the product, the license agreement provides that we will pay royalties based on net sales.



F-13



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



5. Iloperidone Sublicense to Novartis Pharma AG

We entered into an agreement with Novartis in 1997 pursuant to which we granted Novartis a sublicense for the worldwide
(with the exception of Japan) development, manufacturing and marketing of iloperidone. In April 2001, we entered into an amendment to the agreement for the development and commercialization of iloperidone in Japan. Under the amendment, in exchange
for rights to iloperidone in Japan, we received a $2.5 million license fee in May 2001. Novartis will make our milestone payments to Sanofi-Aventis during the life of the Novartis agreement, and will also pay to Sanofi-Aventis and us a royalty on
future net sales of the product, providing us with a net royalty of 8% on the first $200.0 million of sales annually and 10% on all sales above $200.0 million on an annual basis. Novartis has assumed the responsibility for all clinical development,
registration, manufacturing and marketing of iloperidone, and we have no remaining obligations under the terms of this agreement, except for maintaining certain usual and customary requirements, such as confidentiality covenants.

In June 2004, we announced that Vanda had acquired from Novartis the worldwide rights to develop and commercialize iloperidone, our
proprietary antipsychotic agent in Phase 3 clinical development for the treatment of schizophrenia and related psychotic disorders. All of our rights and economic interests in iloperidone, including royalties on sales of iloperidone, remain
essentially unchanged under this agreement.

In May 2009, iloperidone (Fanapt) was approved by the FDA for the treatment of
schizophrenia. In October 2009, Novartis acquired from Vanda the rights to commercialize Fanapt in the United States and Canada.

In October 2012, we were notified by Novartis that it had decided to cease further development of the long-acting injectable, or depot, formulation of iloperidone. Novartis will continue to commercialize
Fanapt®, the oral formulation of iloperidone, in the U.S. and under the terms of the sublicense agreement. In
November 2011, we sold substantially all of our remaining future royalties on the sales of Fanapt® to Deerfield,
and accordingly the future royalty payments owed to us by Novartis will continue to be transmitted to Deerfield upon receipt from Novartis per the terms of the agreement with Deerfield. See Note 8, Royalty Liability for further
discussion of our royalty liabilities.

6. Braeburn License

In December 2012, we entered into a license agreement with Braeburn granting Braeburn exclusive commercialization
rights to Probuphine in the United States and Canada. As part of the agreement, we received a non-refundable up-front license fee of $15.75 million (approximately $15.0 million, net of expenses), and will receive a $50.0 million milestone payment
upon approval by the FDA of the NDA. We will be eligible to receive up to $130.0 million upon achievement of specified sales milestones and up to $35.0 million in regulatory milestones for additional indications, including chronic pain. We will
receive tiered royalties on net sales of Probuphine ranging from the mid-teens to the low twenties. In addition, Apple Tree Partners IV, Braeburns parent company, has allocated in excess of $75.0 million to launch, commercialize and continue
the development of Probuphine.

We have evaluated the revenue components of this license agreement, which includes multiple
elements, to determine whether the components of the arrangement represent separate units of accounting.

We have determined
that the non-refundable, up-front license fee of $15.75 million (approximately $15.0 million, net of expenses) and our costs up to the PDUFA date to be one deliverable which will be accounted for as a single unit of accounting. This amount will
be recognized on a straight-line basis over the estimated period to reach FDA approval and meet the contract deliverables, including the transition of production and supply services of the product to Braeburn. Based on our understanding of
subsequent steps to be performed



F-14



---

TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



following the PDUFA date related to the completion of the transition of production and supply services to Braeburn, we estimate the revenue recognition period for the up-front payment to be
approximately 12 months from the date of this agreement. Accordingly, we will recognize revenue for the up-front payment ratably from December 14, 2012, the date of the agreement, through December 14, 2013 at an amount equal to
approximately $1.25 million per month. As of December 31, 2012, we have recognized approximately $0.6 million in license revenue and recorded deferred revenues of $14.4 million related to the up-front payment. Internal and external research and
development costs related to this product will be expensed in the period incurred.

Under the license agreement, we will
receive a $50.0 million milestone payment from Braeburn within 10 days following the achievement of FDA approval of the product NDA. As such, upon receipt of FDA approval our obligation will be fulfilled. As the milestone payment relates solely to
past performance, i.e. FDA approval, we will recognize the $50.0 million regulatory milestone payment from Braeburn on the date of achievement of FDA approval in accordance with the milestone method of revenue recognition. Following FDA approval, we
will be reimbursed by Braeburn for any development services and activities performed by us at Braeburns request.

The
license agreement also provides for a development committee. The duties of the development committee are to periodically report to each other, exchange information, and confer with and review the clinical development of the product and matters
pertaining to regulatory approval. The development committee has no authority to approve or direct either party to take action, approve or withhold approval for any plan, budget, timeline or strategies, amend, modify or waive compliance with the
license agreement, create new obligations or alter, increase or expand, or waive compliance with the license agreement, create new obligations not specified in the license agreement, or alter, increase or expand, or waive compliance by a party with
obligations under the license agreement. The development committee can be disbanded upon mutual agreement of the parties and shall automatically disband six years after the NDA transfer date. Based on the above, we have determined that participation
in the development committee is perfunctory and inconsequential, and is not considered a separate deliverable in the license agreement.

7. Commitments and Contingencies

Financing Agreements

In December 2009, we entered into a loan and security agreement with Oxford Capital Financing (Oxford) pursuant to which we received a three-year term loan in the principal amount of $3.0
million that bears interest at the rate of 13% per annum. We paid Oxford an initial facility fee of $60,000 and are obligated to make a final payment fee of $180,000. Commencing in January 2010, the loan is repayable in monthly interest
payments of $32,500 through June 2010 followed by monthly interest and principal installments of $117,665 commencing in July 2010 through December 2012. The loan is secured by our assets and has a provision for pre-payment. We also issued to Oxford,
in connection with the loan and security agreement, five-year warrants to purchase 42,254 shares of our common stock at an exercise price of $2.13 per share. The relative fair value attributable to the warrants of $88,995 was recorded as a discount
to the debt and corresponding credit to additional paid-in capital. The debt discount will be amortized to interest expense over the life of the debt. Interest on the term loan, consisting of the stated interest rate, initial facility fee, final
payment fee and amortization of the discount, is being recognized using the interest method. The effective annual interest rate on the loan is approximately 21.1%.

In September 2010, we amended our loan and security agreement with Oxford pursuant to which we received a 39 month term loan in the principal amount of $5.0 million that bears interest at the rate of
13% per annum. We paid Oxford an initial facility fee of $125,000 and are obligated to make a final payment fee of



F-15



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



$300,000. Commencing in October 2010, the loan is repayable in monthly interest payments of $54,167 through June 2011 followed by monthly interest and principal installments of $196,108
commencing in July 2011 through December 2013. The loan is secured by our assets and has a provision for pre-payment. We also issued to Oxford, in connection with the loan and security agreement, five-year warrants to purchase 287,356 shares of our
common stock at an exercise price of $0.87 per share. The relative fair value attributable to the warrants of $254,580 was recorded as a discount to the debt and corresponding credit to additional paid-in capital. The debt discount is being
amortized to interest expense over the life of the debt. Interest on the term loan, consisting of the stated interest rate, initial facility fee, final payment fee and amortization of the discount, is being recognized using the interest method. The
effective annual interest rate on the loan is approximately 22.6%.

On March 15, 2011, we entered into several agreements
pursuant to which Deerfield agreed to provide $20.0 million in funding to us. Funding occurred on April 5, 2011 and we used approximately $7.6 million of proceeds from the Deerfield funding to repay Oxford in full, including required final
payments aggregating $480,000. Pursuant to the terms of a facility agreement, we issued Deerfield promissory notes in the aggregate principal amount of $20.0 million. The long-term debt bears interest at 8.5% per annum, payable quarterly, and
was originally repayable over five years, with 10% of the principal amount due on the first anniversary, 15% due on the second anniversary, and 25% due on each of the next three anniversaries. We paid Deerfield a facility fee of $0.5 million. The
long-term debt is secured by our assets and has a provision for pre-payment. Deerfield has the right to have the long-term debt repaid at 110% of the principal amount in the event we complete a major transaction, which includes, but is not limited
to, a merger or sale of our company or the sale of Probuphine. In connection with the facility agreement, we issued Deerfield six-year warrants to purchase 6,000,000 shares of our common stock at an exercise price of $1.57 per share (See Note 9,
Warrant Liabilities for further discussion). As a result of our April 2012 subscription agreements, and pursuant to the terms of the Deerfield Warrants, the exercise price of the Deerfield Warrants was adjusted to $1.25 per share. (see
Note 11, Stockholders Deficit for further discussion). We also entered into a royalty agreement with Deerfield in exchange for $3.0 million (see Note 8, Royalty Liability for further discussion).

We recorded the promissory notes with an aggregate principal amount of $20.0 million at its face value less a note discount consisting of
(i) $3.0 million cash discount, (ii) a $500,000 loan fee, and (iii) the $5.5 million fair value of the associated warrants. The note discount totaling $9.0 million is being amortized using the interest method. The effective annual
interest rate on the note was 33% based on the note discount amortization, stated interest rate and note term.

On
November 14, 2011, we entered into several agreements with Deerfield pursuant to which we agreed to pay a substantial portion of the remaining future royalties on the sales of Fanapt to Deerfield in exchange for $5.0 million in cash that
was recorded as royalty liability (see Note 8, Royalty Liability for further discussion), a $10.0 million reduction in the principal amount owed to Deerfield under the existing facility agreement and a revised principal repayment
schedule of $2.5 million per year for four years commencing in April 2013 to retire the remaining long-term debt of $10.0 million. We evaluated the November 2011 principal reduction and other amendments to the $20.0 million facility agreement and
determined that the modifications should be accounted for as a troubled debt restructuring on a prospective basis. As a result, we will recognize the difference between the carrying value of the long-term debt and the total required future principal
and interest payments as interest expense over the remaining term using the interest method.



F-16



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



The following is a schedule of future minimum long-term debt payments at
December 31, 2012 (in thousands):



|                    |  |   |        | 
|------------------- |  | - | ------ | 
|2013                |  | $ | 3,262  | 
|2014                |  |   | 3,049  | 
|2015                |  |   | 2,836  | 
|2016                |  |   | 2,624  | 
|2017 and thereafter |  |   |       | 
|                    |  |   |        | 
|                    |  | $ | 11,771 | 
|                    |  |   |        | 

These future minimum long-term debt payments exclude payments related to the royalty liability with Deerfield under the
March 2011 and November 2011 royalty agreements. (see Note 16. Subsequent Events for further discussion).

Lease Commitments

We lease facilities under operating leases that expire at various dates through June 2013. We also lease certain office equipment under operating leases that expire at various dates through December 2013.
Rent expense was $203,000, $214,000, and $257,000 for years ended December 31, 2012, 2011, and 2010, respectively.

The
following is a schedule of future minimum lease payments at December 31, 2012 (in thousands):



|                    |  |   |     | 
|------------------- |  | - | --- | 
|2013                |  | $ | 121 | 
|2014 and thereafter |  |   |    | 
|                    |  |   |     | 
|                    |  | $ | 121 | 
|                    |  |   |     | 

Legal Proceedings

There are no ongoing legal proceedings against the Company.

8. Royalty Liability

On March 15, 2011, under a royalty agreement, in exchange for $3.0 million that was recorded as royalty liability,
we agreed to pay Deerfield 2.5% of the net sales of Fanapt, constituting a portion of the royalty revenue that we are entitled to under our sublicense agreement with Novartis. The agreements with Deerfield also provide us with the option to
repurchase the royalty rights for $40.0 million.

The $3.0 million received under the March 2011 royalty agreement was
recorded as a royalty liability in accordance with the appropriate accounting guidance as the related agreement includes a provision which allows us to repurchase the royalty rights from Deerfield through a payment of a lump sum. Interest on the
royalty liability is being recognized using the interest method based on the estimated future royalties expected to be paid under the royalty agreement. The current effective annual interest rate is 43.1%.



F-17



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Under the November 14, 2011 royalty agreement, in exchange for additional $5.0
million royalty liability Deerfield is entitled to the balance of our portion of the royalties on Fanapt (5.5% to 7.5% of net sales, net of the 2.5% previously agreed to have been provided to Deerfield) up to specified threshold levels of net sales
of Fanapt and 40% of the royalties above the threshold level. We retain 60% of the royalties on net sales of Fanapt above the threshold levels, subject to an agreement that half of any such retained royalties will go towards repayment of our
outstanding debt to Deerfield. Funding occurred on November 25, 2011. The proceeds of this transaction were used to advance the development of Probuphine and for general corporate purposes.

The $5.0 million received under the November 2011 royalty agreement was recorded as a royalty liability in accordance with the
appropriate accounting guidance as the related agreement includes a provision which allows us to repurchase the royalty rights from Deerfield through a payment of a lump sum. Interest on this royalty obligation is being recognized using the interest
method based on the estimated future royalties expected to be paid under the royalty agreement. The current effective annual interest rate is 67.3%.

9. Warrant Liability

On March 15, 2011, in connection with the Deerfield facility agreement, we issued Deerfield six-year warrants to
purchase 6,000,000 shares of our common stock at an initial exercise price of $1.57 per share (Deerfield Warrants). As a result of our April 2012 subscription agreements, and pursuant to the terms of the Deerfield Warrants, the exercise
price of the Deerfield Warrants was adjusted to $1.25 per share. (see Note 11, Stockholders Deficit for further discussion). The Deerfield Warrants were immediately exercisable and expire on March 15, 2017. The Deerfield
Warrants contain a provision where the warrant holder has the option to receive cash, equal to the Black-Scholes fair value of the remaining unexercised portion of the warrant, as cash settlement in the event that there is a fundamental transaction
(contractually defined to include various merger, acquisition or stock transfer activities). Due to this provision, ASC 480 Distinguishing Liabilities from Equity requires that these warrants be classified as liabilities. The fair values of
these warrants have been determined using the Binomial Lattice (Lattice) valuation model, and the changes in the fair value are recorded in the Consolidated Statement of Operations and Comprehensive Loss. The Lattice model provides for
assumptions regarding volatility and risk-free interest rates within the total period to maturity.

The key assumptions used to value the
Deerfield Warrants were as follows:



|                                        |  |              |      |  
|--------------------------------------- |  | ------------ | ---- | -
|                                        |  | December 31, |     
|Assumption                              |  | 2012         |     
|Expected price volatility               |  |              | 80   | %
|Expected term (in years)                |  |              | 4.21 |  
|Risk-free interest rate                 |  |              | 0.58 | %
|Dividend yield                          |  |              | 0.00 | %
|Weighted-average fair value of warrants |  | $            | 0.62 |  

On April 9, 2012, in connection with subscription agreements with certain institutional investors for the purchase
and sale of 6,517,648 shares of our common stock, we issued (i) six-year Series A Warrants to purchase 6,517,648 shares of common stock at an exercise price of $1.15 per share and (ii) six-month Series B Warrants to purchase 6,517,648
shares of common stock at an exercise price of $0.85 per share. The Series A and Series B Warrants contain a provision where the warrant holder has the option to receive cash, equal to the Black Scholes fair value of the remaining unexercised
portion of the warrant, as cash settlement in the event that there is a fundamental transaction (contractually defined to include various merger, acquisition or stock transfer activities). Due to this provision, ASC 480 Distinguishing Liabilities
from Equity requires that these warrants be classified



F-18



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



as liabilities. The fair values of these warrants have been determined using the Lattice valuation model, and the changes in the fair value are recorded in the Consolidated Statements of
Operations and Comprehensive Loss. The Lattice model provides for assumptions regarding volatility and risk-free interest rates within the total period to maturity.

During the year ended December 31, 2012, Series B Warrants to purchase 5,761,765 shares of common stock were exercised at a price of $0.85 per share. The remaining Series B Warrants to purchase
755,883 shares of common stock expired in October 2012.

The key assumptions used to value the Series A Warrants were as follows:



|                                        |  |                  |      |  
|--------------------------------------- |  | ---------------- | ---- | -
|Assumption                              |  | December 31,2012 |     
|Expected price volatility               |  |                  | 80   | %
|Expected term (in years)                |  |                  | 5.27 |  
|Risk-free interest rate                 |  |                  | 0.78 | %
|Dividend yield                          |  |                  | 0.00 | %
|Weighted-average fair value of warrants |  | $                | 0.69 |  

10. Guarantees and Indemnifications

As permitted under Delaware law and in accordance with our Bylaws, we indemnify our officers and directors for certain
events or occurrences while the officer or director is or was serving at our request in such capacity. The term of the indemnification period is for the officers or directors lifetime. The maximum amount of potential future
indemnification is unlimited; however, we have a director and officer insurance policy that limits our exposure and may enable us to recover a portion of any future amounts paid. We believe the fair value of these indemnification agreements is
minimal. Accordingly, we have not recorded any liabilities for these agreements as of December 31, 2012.

In the normal
course of business, we have commitments to make certain milestone payments to various clinical research organizations in connection with our clinical trial activities. Payments are contingent upon the achievement of specific milestones or events as
defined in the agreements, and we have made appropriate accruals in our consolidated financial statements for those milestones that were achieved as of December 31, 2012. We also provide indemnifications of varying scope to our CROs and
investigators against claims made by third parties arising from the use of our products and processes in clinical trials. Historically, costs related to these indemnification provisions were immaterial. We also maintain various liability insurance
policies that limit our exposure. We are unable to estimate the maximum potential impact of these indemnification provisions on our future results of operations.

11. Stockholders Deficit

Common Stock

In October 2012, Series B Warrants to purchase 4,627,941 shares of common stock were exercised resulting in gross proceeds of approximately $3,934,000.

In September 2012, Series B Warrants to purchase 1,133,824 shares of common stock were exercised resulting in gross proceeds of
approximately $964,000.

In September 2012, we entered into a stock purchase and option agreement with an affiliate of
Braeburn pursuant to which we sold 3,400,000 shares of our common stock for an aggregate purchase price of



F-19



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



$4.25 million, or $1.25 per share, and agreed to an exclusive option period for execution of the proposed license agreement. The $1.7 million premium, or $0.50 per share, has been allocated
to the fair value of the option agreement and was recorded as license revenue in 2012.

In April 2012, we entered into
subscription agreements with certain institutional investors for the purchase and sale, in a registered direct offering, of (i) 6,517,648 shares of our common stock, (ii) 6,517,648 Series A Warrants and (iii) 6,517,648 Series B
Warrants for gross proceeds of $5,540,000 (the Offering). The Offering closed in April 2012. As a result of the Offering, and pursuant to the terms of the Deerfield Warrants, the exercise price of the Deerfield Warrants (See Note 9,
Warrant Liabilities for further discussion) was adjusted to $1.25 per share.

We recorded the gross proceeds from
the Offering, net of (i) issuance costs of $0.5 million and (ii) the fair value of the Warrants of $2.9 million (see Note 9, Warrant Liabilities), as common stock paid-in in the Consolidated Balance Sheets.

As of December 31, 2012, warrants to purchase shares of common stock consisted of the following (in thousands, except per share
price):



| |  |             |  |                 |  |                |  |                                  |  | 
| |  | ----------- |  | --------------- |  | -------------- |  | -------------------------------- |  | 
| |  | Date Issued |  | Expiration Date |  | Exercise Price |  | Outstanding at
December 31, 2012 |  | 
| |  | 12/18/2009  |  | 12/18/2014      |  | $    2.13      |  | 42                               |  | 
| |  | 09/27/2010  |  | 09/27/2015      |  | $    0.87      |  | 288                              |  | 
| |  | 03/15/2011  |  | 03/15/2017      |  | $    1.25      |  | 6,000                            |  | 
| |  | 04/13/2012  |  | 04/13/2018      |  | $    1.15      |  | 6,517                            |  | 
| |  |             |  |                 |  |                |  |                                  |  | 
| |  |             |  |                 |  |                |  | 12,847                           |  | 
| |  |             |  |                 |  |                |  |                                  |  | 

Shares Reserved for Future Issuance

As of December 31, 2012, shares of common stock reserved by us for future issuance consisted of the following (in thousands):



|                                              |  |  |        | 
|--------------------------------------------- |  |  | ------ | 
|Stock options outstanding                     |  |  | 6,842  | 
|Shares issuable upon the exercise of warrants |  |  | 12,847 | 
|                                              |  |  |        | 
|                                              |  |  | 19,689 | 
|                                              |  |  |        | 

12. Stock Plans

In July 2002, we adopted the 2002 Stock Incentive Plan (2002 Plan). The 2002 Plan assumed the options which
remain available for grant under our option plans previously approved by stockholders. Under the 2002 Plan and predecessor plans, a total of 7.4 million shares of our common stock were authorized for issuance to employees, officers, directors,
consultants, and advisers. In August 2005, we adopted an amendment to the 2002 Stock Incentive Plan (2002 Plan) to (i) permit the issuance of shares of restricted stock and stock appreciation rights to participants under the 2002
Plan, and (ii) increase the number of shares issuable pursuant to grants under the 2002 Plan from 2,000,000 to 3,000,000. Options granted under the 2002 Plan and predecessor plans may either be incentive stock options within the meaning of
Section 422 of the Internal Revenue Code and/or options that do not qualify as incentive stock options; however, only employees are eligible to receive incentive stock options. Options granted under the option plans generally expire no later
than ten years from the date of grant,



F-20



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



except when the grantee is a 10% shareholder, in which case the maximum term is five years from the date of grant. Options generally vest at the rate of one fourth after one year from the date of
grant and the remainder ratably over the subsequent three years, although options with different vesting terms are granted from time-to-time. Generally, the exercise price of any options granted under the 2002 Plan must be at least 100% of the fair
market value of our common stock on the date of grant, except when the grantee is a 10% shareholder, in which case the exercise price shall be at least 110% of the fair market value of our common stock on the date of grant. The 2002 Plan expired by
its terms in July 2012. On December 31, 2012, options to purchase an aggregate of 4,280,153 shares of our common stock were outstanding under the 2002 Plan.

Commencing in 2008, non-employee directors are entitled to receive stock options including an initial grant of 10,000 options upon becoming a director, an annual grant of 20,000 options thereafter, and an
annual grant of 5,000 options for each committee on which they serve.

In August 2001, we adopted the 2001 Employee
Non-Qualified Stock Option Plan (2001 NQ Plan) pursuant to which 1,750,000 shares of common stock were authorized for issuance for option grants to employees and consultants who are not officers or directors of Titan. Options granted
under the option plans generally expire no later than ten years from the date of grant. Option vesting schedule and exercise price are determined at time of grant by the board of directors. Historically, the exercise prices of options granted under
the 2001 NQ Plan were 100% of the fair market value of our common stock on the date of grant. The 2001 Stock Option Plan expired by its terms in August 2011. On December 31, 2012, options to purchase an aggregate of 1,199,500 shares of our
common stock were outstanding under the 2001 NQ Plan.

Activity under our stock plans, as well as non-plan activity, are
summarized below (shares in thousands):



|                              |  |                                     |        |   |                                       |  |        |                                |  |   |       | 
|----------------------------- |  | ----------------------------------- | ------ | - | ------------------------------------- |  | ------ | ------------------------------ |  | - | ----- | 
|                              |  | Shares orAwards 
AvailableFor Grant |        |   | Number ofOptions andAwardsOutstanding |  |        | Weighted AverageExercise
Price | 
|Balance at December 31, 2009  |  |                                     | 2,418  |   |                                       |  | 6,090  |                                |  | $ | 3.68  | 
|Options granted               |  |                                     | (150   | ) |                                       |  | 150    |                                |  | $ | 2.36  | 
|Options cancelled and expired |  |                                     | 1,244  |   |                                       |  | (1,243 | )                              |  | $ | 9.11  | 
|Awards granted                |  |                                     | (119   | ) |                                       |  | 119    |                                |  | $ | 0.00  | 
|                              |  |                                     |        |   |                                       |  |        |                                |  |   |       | 
|Balance at December 31, 2010  |  |                                     | 3,393  |   |                                       |  | 5,115  |                                |  | $ | 2.29  | 
|Options granted               |  |                                     | (734   | ) |                                       |  | 734    |                                |  | $ | 1.44  | 
|Options cancelled and expired |  |                                     | 45     |   |                                       |  | (241   | )                              |  | $ | 15.01 | 
|Options forfeited             |  |                                     | 55     |   |                                       |  | (55    | )                              |  | $ | 1.77  | 
|Awards granted                |  |                                     | (181   | ) |                                       |  | 181    |                                |  | $ | 0.00  | 
|Awards issued                 |  |                                     |       |   |                                       |  | (139   | )                              |  | $ | 0.00  | 
|                              |  |                                     |        |   |                                       |  |        |                                |  |   |       | 
|Balance at December 31, 2011  |  |                                     | 2,578  |   |                                       |  | 5,595  |                                |  | $ | 1.56  | 
|Options granted               |  |                                     | (1,718 | ) |                                       |  | 1,718  |                                |  | $ | 1.14  | 
|Options cancelled and expired |  |                                     | 290    |   |                                       |  | (290   | )                              |  | $ | 5.54  | 
|Awards issued                 |  |                                     |       |   |                                       |  | (181   | )                              |  | $ | 0.00  | 
|Expiration of option plan     |  |                                     | (1,150 | ) |                                       |  |       |                                |  | $ | 0.00  | 
|                              |  |                                     |        |   |                                       |  |        |                                |  |   |       | 
|Balance at December 31, 2012  |  |                                     |       |   |                                       |  | 6,842  |                                |  | $ | 1.33  | 
|                              |  |                                     |        |   |                                       |  |        |                                |  |   |       | 

Our option plans allow for stock options issued as the result of a merger or consolidation of another entity, including
the acquisition of minority interest of our subsidiaries, to be added to the maximum number of shares



F-21



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



provided for in the plan (Substitute Options). Consequently, Substitute Options are not returned to the shares reserved under the plan when cancelled. During 2012, 2011 and 2010, the
number of Substitute Options cancelled was immaterial.

Options for 6.0 million and 4.3 million shares were
exercisable at December 31, 2012 and 2011, respectively. The options outstanding at December 31, 2012 have been segregated into four ranges for additional disclosure as follows (options in thousands):



|                         |  |                     |       |  |                                      |  |      |                               |  |   |                   |  |  |                               |       |  |  |   |      | 
|------------------------ |  | ------------------- | ----- |  | ------------------------------------ |  | ---- | ----------------------------- |  | - | ----------------- |  |  | ----------------------------- | ----- |  |  | - | ---- | 
|                         |  | Options Outstanding |       |  | Options Exercisable                  | 
|Range of Exercise Prices |  | NumberOutstanding   |       |  | WeightedAverageRemainingLife (Years) |  |      | WeightedAverageExercise Price |  |   | NumberExercisable |  |  | WeightedAverageExercise Price |      
|$0.69 - $1.53            |  |                     | 5,499 |  |                                      |  | 7.22 |                               |  | $ | 1.05              |  |  |                               | 4,753 |  |  | $ | 1.04 | 
|$1.54 - $2.38            |  |                     | 604   |  |                                      |  | 4.85 |                               |  | $ | 2.19              |  |  |                               | 542   |  |  | $ | 2.19 | 
|$2.39 - $3.22            |  |                     | 642   |  |                                      |  | 4.27 |                               |  | $ | 2.52              |  |  |                               | 642   |  |  | $ | 2.52 | 
|$3.23 - $4.06            |  |                     | 97    |  |                                      |  | 1.01 |                               |  | $ | 3.55              |  |  |                               | 97    |  |  | $ | 3.55 | 
|                         |  |                     |       |  |                                      |  |      |                               |  |   |                   |  |  |                               |       |  |  |   |      | 
|$0.69 - $4.06            |  |                     | 6,842 |  |                                      |  | 6.65 |                               |  | $ | 1.33              |  |  |                               | 6,034 |  |  | $ | 1.35 | 
|                         |  |                     |       |  |                                      |  |      |                               |  |   |                   |  |  |                               |       |  |  |   |      | 

In addition, Ingenex, Inc., a consolidated subsidiary, had a stock option plan under which options to purchase common
stock of Ingenex could have been granted. No options have been granted under such plan since 1997.

We use the
Black-Scholes-Merton option-pricing model with the following assumptions to estimate the stock-based compensation expense for the years ended December 31, 2012, 2011 and 2010:



|                                                                    |  |                          |      |   |      |  |      |      |  |  |      |  
|------------------------------------------------------------------- |  | ------------------------ | ---- | - | ---- |  | ---- | ---- |  |  | ---- | -
|                                                                    |  | Years Ended December 31, |     
|                                                                    |  | 2012                     |      |   | 2011 |  |      | 2010 | 
|Weighted-average risk-free interest rate                            |  |                          | 0.91 | % |      |  | 2.3  | %    |  |  | 2.3  | %
|Expected dividend payments                                          |  |                          |     |   |      |  |     |      |  |  |     |  
|Expected holding period (years)(1)                                  |  |                          | 5.1  |   |      |  | 5.4  |      |  |  | 4.2  |  
|Weighted-average volatility factor(2)                               |  |                          | 1.75 |   |      |  | 1.71 |      |  |  | 1.89 |  
|Estimated forfeiture rates for options granted to management(3)     |  |                          | 23   | % |      |  | 23   | %    |  |  | 23   | %
|Estimated forfeiture rates for options granted to non-management(3) |  |                          | 41   | % |      |  | 41   | %    |  |  | 41   | %



|(1) | Expected holding period is based on historical experience of similar awards, giving consideration to the contractual terms of the stock-based awards, vesting schedules
and the expectations of future employee behavior.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Weighted average volatility is based on the historical volatility of the Companys common stock.
|--- | ------------------------------------------------------------------------------------------------

|(3) | Estimated forfeiture rates are based on historical data.
|--- | --------------------------------------------------------

Based upon the above methodology, the weighted-average fair value of options and awards granted during the years ended
December 31, 2012, 2011 and 2010 was $1.09, $1.38 and $2.24, respectively.



F-22



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TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



The following table summarizes the stock-based compensation expense and impact on our
basic and diluted loss per share for the years ended December 31, 2012, 2011 and 2010:



|                                                 |  |                          |       |   |      |   |       |      |  |   |       |  
|------------------------------------------------ |  | ------------------------ | ----- | - | ---- | - | ----- | ---- |  | - | ----- | -
|                                                 |  | Years Ended December 31, |      
|(in thousands, except per share amounts)         |  | 2012                     |       |   | 2011 |   |       | 2010 | 
|Research and development                         |  | $                        | 1,560 |   |      | $ | 371   |      |  | $ | 202   |  
|General and administrative                       |  |                          | 1,021 |   |      |   | 806   |      |  |   | 531   |  
|                                                 |  |                          |       |   |      |   |       |      |  |   |       |  
|Total stock-based compensation expenses          |  | $                        | 2,581 |   |      | $ | 1,177 |      |  | $ | 733   |  
|                                                 |  |                          |       |   |      |   |       |      |  |   |       |  
|Increase in basic and diluted net loss per share |  | $                        | (0.04 | ) |      | $ | (0.02 | )    |  | $ | (0.01 | )
|                                                 |  |                          |       |   |      |   |       |      |  |   |       |  

No tax benefit was recognized related to stock-based compensation expense since we have incurred operating losses and
we have established a full valuation allowance to offset all the potential tax benefits associated with our deferred tax assets.

During the year ended December 31, 2012 we granted 1,718,000 options to employees, directors and consultants to purchase common stock. The following table summarizes option activity for the year
ended December 31, 2012:



|                                         |  |        |       |   |                              |   |      |                                         |  |  |                         |  |  |   |     | 
|---------------------------------------- |  | ------ | ----- | - | ---------------------------- | - | ---- | --------------------------------------- |  |  | ----------------------- |  |  | - | --- | 
|(in thousands, except per share amounts) |  | Shares |       |   | WeightedAverageExercisePrice |   |      | WeightedAverageRemainingContractualTerm |  |  | AggregateIntrinsicValue | 
|Outstanding at January 1, 2012           |  |        | 5,414 |   |                              | $ | 1.61 |                                         |  |  |                         |  |  |   |     | 
|Granted                                  |  |        | 1,718 |   |                              |   | 1.14 |                                         |  |  |                         |  |  |   |     | 
|Cancelled                                |  |        | (290  | ) |                              |   | 5.54 |                                         |  |  |                         |  |  |   |     | 
|                                         |  |        |       |   |                              |   |      |                                         |  |  |                         |  |  |   |     | 
|Outstanding at December 31, 2012         |  |        | 6,842 |   |                              | $ | 1.33 |                                         |  |  | 6.65                    |  |  | $ | 722 | 
|                                         |  |        |       |   |                              |   |      |                                         |  |  |                         |  |  |   |     | 
|Exercisable at December 31, 2012         |  |        | 6,035 |   |                              | $ | 1.35 |                                         |  |  | 6.44                    |  |  | $ | 675 | 
|                                         |  |        |       |   |                              |   |      |                                         |  |  |                         |  |  |   |     | 

As of December 31, 2012, there was approximately $0.3 million of total unrecognized compensation expense related
to non-vested stock options. This expense is expected to be recognized over a weighted-average period of 0.18 years.

There
were no awards of restricted stock during the year ended December 31, 2012. The following table summarizes restricted stock activity for the year ended December 31, 2012:



|                                         |  |        |      |   |                              |   |      |                                         |  |  |                         |  |  |   |   | 
|---------------------------------------- |  | ------ | ---- | - | ---------------------------- | - | ---- | --------------------------------------- |  |  | ----------------------- |  |  | - | - | 
|(in thousands, except per share amounts) |  | Shares |      |   | WeightedAverageExercisePrice |   |      | WeightedAverageRemainingContractualTerm |  |  | AggregateIntrinsicValue | 
|Outstanding at January 1, 2012           |  |        | 181  |   |                              | $ | 0.00 |                                         |  |  |                         |  |  |   |   | 
|Shares issued                            |  |        | (181 | ) |                              |   | 0.00 |                                         |  |  |                         |  |  |   |   | 
|                                         |  |        |      |   |                              |   |      |                                         |  |  |                         |  |  |   |   | 
|Outstanding at December 31, 2012         |  |        |     |   |                              | $ | 0.00 |                                         |  |  |                        |  |  | $ |  | 
|                                         |  |        |      |   |                              |   |      |                                         |  |  |                         |  |  |   |   | 
|Vested at December 31, 2012              |  |        |     |   |                              | $ |     |                                         |  |  |                        |  |  | $ |  | 
|                                         |  |        |      |   |                              |   |      |                                         |  |  |                         |  |  |   |   | 

As of December 31, 2012, there was no unrecognized compensation expense related to non-vested awards.



F-23



---

TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



13. Non-controlling Interest

The $1.2 million received by Ingenex, Inc. upon the issuance of its Series B convertible preferred stock was classified
as non-controlling interest in the consolidated balance sheet prior to December 31, 2010. As a result of the Series B preferred stockholders liquidation preference, the balance was not reduced by any portion of the losses of Ingenex, Inc.

In December 2010, Ingenex, Inc. was dissolved under the laws of Delaware. Upon dissolution, no amounts were distributed to
the Series B convertible preferred stockholders. The dissolution was accounted for as an equity transaction, and the preferred stock carrying value, classified as a non-controlling interest, was reclassified to additional paid-in capital in the
accompanying consolidated balance sheet at December 31, 2010.

14. Income Taxes

As of December 31, 2012, we had net operating loss carryforwards for federal income tax purposes of approximately
$215.7 million that expire at various dates through 2032, and federal research and development tax credits of approximately $7.6 million that expire at various dates through 2031. We also had net operating loss carryforwards for California income
tax purposes of approximately $146.7 million that expire at various dates through 2032 and state research and development tax credits of approximately $7.8 million which do not expire. Approximately $12.4 million of federal and state net operating
loss carryforwards represent stock option deductions arising from activity under the Companys stock option plan, the benefit of which will increase additional paid in capital when realized.

Current federal and California tax laws include substantial restrictions on the utilization of net operating losses and tax credits in
the event of an ownership change of a corporation. We have performed a change in ownership analysis through December 31, 2012 and, accordingly, all of our net operating loss and tax credit carryforwards are available to offset future taxable
income, if any.

Deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of
assets and liabilities for financial reporting purposes and the amounts used for income tax purposes and operating loss and credit carryforwards. Significant components of our deferred tax assets are as follows (in thousands):



|                                 |  |              |          |   |      |   |          |  
|-------------------------------- |  | ------------ | -------- | - | ---- | - | -------- | -
|                                 |  | December 31, |         
|                                 |  | 2012         |          |   | 2011 |  
|Deferred tax assets:             |  |              |          |   |      |   |          |  
|Net operating loss carryforwards |  | $            | 81,127   |   |      | $ | 84,328   |  
|Research credit carryforwards    |  |              | 12,750   |   |      |   | 12,484   |  
|Other, net                       |  |              | 4,190    |   |      |   | 3,883    |  
|Deferred revenue                 |  |              | 5,749    |   |      |   |         |  
|                                 |  |              |          |   |      |   |          |  
|Total deferred tax assets        |  |              | 103,816  |   |      |   | 100,695  |  
|Valuation allowance              |  |              | (103,816 | ) |      |   | (100,695 | )
|                                 |  |              |          |   |      |   |          |  
|Net deferred tax assets          |  | $            |         |   |      | $ |         |  
|                                 |  |              |          |   |      |   |          |  

Realization of deferred tax assets is dependent upon future earnings, if any, the timing and amount of which are
uncertain. Accordingly, the net deferred tax assets have been fully offset by a valuation allowance. The valuation allowance increased by $3.1 million during 2012, decreased by $1.3 million during 2011 and increased by $0.8 million during 2010.

Under ASC 718, the deferred tax asset for net operating losses as of December 31, 2012 excludes deductions for excess
tax benefits related to stock based compensation.



F-24



---

TITAN PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



The provision for income taxes consists of state minimum taxes due. The effective tax
rate of our provision (benefit) for income taxes differs from the federal statutory rate as follows (in thousands):



|                                            |  |                          |        |   |      |   |        |      |  |   |        |  
|------------------------------------------- |  | ------------------------ | ------ | - | ---- | - | ------ | ---- |  | - | ------ | -
|                                            |  | Year Ending December 31, |       
|                                            |  | 2012                     |        |   | 2011 |   |        | 2010 | 
|Computed at 34%                             |  | $                        | (5,134 | ) |      | $ | (5,168 | )    |  | $ | (2,265 | )
|State taxes                                 |  |                          | (234   | ) |      |   | (228   | )    |  |   | (1,347 | )
|Book gains (losses) not currently benefited |  |                          | 3,120  |   |      |   | (1,264 | )    |  |   | 844    |  
|Other                                       |  |                          | 1,901  |   |      |   | 2,746  |      |  |   | 2,773  |  
|Disallowed interest expense                 |  |                          | 1,363  |   |      |   | 1,457  |      |  |   |       |  
|Income from debt restructuring              |  |                          | (1,615 | ) |      |   | 2,462  |      |  |   |       |  
|Revaluation of warrant liability            |  |                          | 600    |   |      |   |       |      |  |   |       |  
|                                            |  |                          |        |   |      |   |        |      |  |   |        |  
|Total                                       |  | $                        | 1      |   |      | $ | 5      |      |  | $ | 5      |  
|                                            |  |                          |        |   |      |   |        |      |  |   |        |  

We had no unrecognized tax benefits or any amounts accrued for interest and penalties for the three year period ended
December 31, 2012. Our policy will be to recognize interest and penalties related to income taxes as a component of income tax expense.

We file tax returns in the U.S. Federal jurisdiction and some state jurisdictions. We are subject to the U.S. federal and state income tax examination by tax authorities for such years 1995 through 2012,
due to net operating losses that are being carried forward for tax purposes.

The Credit for Increasing Research Activities
expired for amounts incurred after December 31, 2011. However, The American Taxpayer Relief Act of 2012, which was signed into law on January 2 2013, extended the credit for amounts incurred before January 1, 2014. The Act also retroactively
restored the credit for amounts incurred in 2012. However, since the Act was not signed until January 2, 2013 the amount of credit generated in 2012 is not reflected in the deferred tax amounts as of December 31, 2012. The amount of this credit that
was generated in 2012 was approximately $340,000. The deferred tax asset for this credit will be increased by this amount in 2013.

15. Quarterly Financial Data (Unaudited)



|                                     |  |                                         |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|------------------------------------ |  | --------------------------------------- | ------ | - | ------------- | - | ------ | ------------ |  | - | ------------- | - |  | - | ------ | -
|                                     |  | FirstQuarter                            |        |   | SecondQuarter |   |        | ThirdQuarter |  |   | FourthQuarter |  
|                                     |  | (in thousands, except per share amount) |       
|2012                                 |  |                                         |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|Total revenue                        |  | $                                       | 1,270  |   |               | $ | 1,360  |              |  | $ | 1,228         |   |  | $ | 3,259  |  
|Net loss                             |  | $                                       | (5,163 | ) |               | $ | (1,724 | )            |  | $ | (8,013        | ) |  | $ | (280   | )
|Basic and diluted net loss per share |  | $                                       | (0.09  | ) |               | $ | (0.03  | )            |  | $ | (0.12         | ) |  | $ | (0.00  | )
|                                     |  |                                         |        |  
|2011                                 |  |                                         |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|Total revenue                        |  | $                                       | 948    |   |               | $ | 695    |              |  | $ | 1,012         |   |  | $ | 1,413  |  
|Net loss                             |  | $                                       | (4,512 | ) |               | $ | (6,989 | )            |  | $ | (804          | ) |  | $ | (2,898 | )
|Basic and diluted net loss per share |  | $                                       | (0.08  | ) |               | $ | (0.12  | )            |  | $ | (0.01         | ) |  | $ | (0.05  | )

16. Subsequent events

In January 2013, Series A Warrants to purchase 520,776 shares of common stock were exercised resulting in gross
proceeds of approximately $599,000.



F-25



---

On February 6, 2013, the facility agreement dated as of March 11, 2011 with
Deerfield was amended to provide that the exercise price of the Deerfield Warrants may be satisfied through a reduction in the principal amount of our outstanding indebtedness to Deerfield. In February and March 2013, Deerfield exercised an
aggregate of 6,000,000 warrants resulting in a reduction of our outstanding indebtedness to Deerfield of $7.5 million and, accordingly, cancellation of our obligation to make the 2014, 2015 and 2016 installment payments under the facility.

(b)     Exhibits



|      |  |                                                                                                                                                                                      
|----- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|No.   |  | Description                                                                                                                                                                          
|      | 
|3.1   |  | Amended and Restated Certificate of Incorporation of the Registrant, as amended9                                                                                                     
|      | 
|3.2   |  | By-laws of the Registrant1                                                                                                                                                           
|      | 
|3.3   |  | Certificate of Designations of Junior Participating Preferred Stock of Titan Pharmaceuticals, Inc.15                                                                                 
|      | 
|4.1   |  | Registration Rights Agreement dated as of December 17, 20072                                                                                                                         
|      | 
|4.2   |  | Registration Rights Agreement dated as of December 8, 20099                                                                                                                          
|      | 
|4.3   |  | Warrant to Purchase Common Stock dated December 23, 2009 issued to Oxford Finance Corporation9                                                                                       
|      | 
|4.4   |  | Form of Warrant13                                                                                                                                                                    
|      | 
|4.5   |  | Registration Rights Agreement, dated as of March 15, 201113                                                                                                                          
|      | 
|4.6   |  | Form of Series A Warrant18                                                                                                                                                           
|      | 
|10.1  |  | 1998 Stock Option Plan3                                                                                                                                                              
|      | 
|10.2  |  | 2001 Non-Qualified Employee Stock Option
Plan4                                                                                                                                       
|      | 
|10.3  |  | 2002 Stock Option Plan5                                                                                                                                                              
|      | 
|10.4  |  | Employment Agreement between the Registrant and Sunil Bhonsle, dated May 16, 2009, as amended by agreements dated February 17, 2010, December 30, 2011 and December 31,
20129, 16, 19
|      | 
|10.5  |  | Employment Agreement between the Registrant and Marc Rubin, dated May 16, 2009, as amended by agreements dated February 17, 2010, December 30, 2011 and December 31, 2012,9 16, 19   
|      | 
|10.6  |  | Lease for the Registrants facilities, amended as of October 1, 20046                                                                                                                
|      | 
|10.7  |  | Amendments to lease for Registrants facilities dated May 21, 2007 and March 12, 20099                                                                                               
|      | 
|10.8* |  | License Agreement between the Registrant and Sanofi-Aventis SA effective as of December 31, 19967                                                                                    
|      | 
|10.9* |  | Sublicense Agreement between the Registrant and Novartis Pharma AG dated November 20, 19978                                                                                          
|      | 
|10.10 |  | Loan and Security Agreement between the Registrant and Oxford Finance Corporation dated December 18, 20099                                                                           
|      | 
|10.11 |  | Stock Purchase Agreement between the Registrant and certain investors dated December 8, 20099                                                                                        
|      | 
|10.12 |  | Amendment to Employment Agreement dated June 15, 2010 between the Registrant and Marc Rubin10                                                                                        



F-26



---

|          |  |                                                                                                                                                                                                                                                                          
|--------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|No.       |  | Description                                                                                                                                                                                                                                                              
|          | 
|10.13     |  | Amendment to Employment Agreement dated June 15, 2010 between the Registrant and Sunil Bhonsle10                                                                                                                                                                         
|          | 
|10.14     |  | Amendment to lease for Registrants facilities dated June 15, 201011                                                                                                                                                                                                     
|          | 
|10.15     |  | Amended and Restated Loan and Security Agreement between the Registrant and Oxford Finance Corporation dated September 27, 201012                                                                                                                                        
|          | 
|10.16     |  | Facility Agreement, dated as of March 15, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Private Design International II, L.P., Deerfield
Special Situations Fund, L.P., and Deerfield Special Situations Fund International Limited13
|          | 
|10.17     |  | Security Agreement, dated as of March 15, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Private Design International II, L.P., Deerfield
Special Situations Fund, L.P., and Deerfield Special Situations Fund International Limited13
|          | 
|10.18     |  | Royalty Purchase Agreement, dated November 14, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Special Situations Fund, L.P. and Horizon Sante
TTNP SARL14                                                                             
|          | 
|10.19     |  | Amended and Restated Royalty Agreement, dated November 14, 2011 by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Special Situations Fund, L.P. and
Horizon Sante TTNP SARL14                                                                  
|          | 
|10.20     |  | Amended and Restated Royalty Repurchase Agreement, dated November 14, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., and Horizon Sante TTNP SARL14                                                                                              
|          | 
|10.21     |  | Cash Management Agreement, dated November 14, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Special Situations Fund, L.P. and Horizon Sante
TTNP SARL14                                                                              
|          | 
|10.22     |  | Paying Agent Agreement, dated November 14, 2011, by and among the Company, Deerfield Management Company, L.P. and U.S. Bank National Association14                                                                                                                       
|          | 
|10.23     |  | Agreement, dated as of November 14, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Private Design International II, L.P., Deerfield Special
Situations Fund, L.P., and Deerfield Special Situations Fund International Limited14      
|          | 
|10.24     |  | Form of Subscription Agreement dated April 9,
201218                                                                                                                                                                                                                     
|          | 
|10.25*    |  | License Agreement by and between Titan Pharmaceuticals, Inc. and Braeburn Pharmaceuticals Sprl, dated December 14, 201220                                                                                                                                                
|          | 
|14.1      |  | Code of Business Conduct and Ethics21                                                                                                                                                                                                                                    
|          | 
|23.1      |  | Consent of OUM & Co., LLP, Independent Registered Public Accounting Firm                                                                                                                                                                                                 
|          | 
|31.1      |  | Certification of the Principal Executive and Financial Officer pursuant to Rule 13(a)-14(a) of the Securities Exchange Act of 1934                                                                                                                                       
|          | 
|32.1      |  | Certification of the Principal Executive and Financial Officer pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002                                                                                                          
|          | 
|101.INS** |  | XBRL Instance Document21                                                                                                                                                                                                                                                 
|          | 
|101.SCH** |  | XBRL Taxonomy Extension Schema
Document21                                                                                                                                                                                                                                
|          | 
|101.CAL** |  | XBRL Taxonomy Extension Calculation Linkbase
Document21                                                                                                                                                                                                                  
|          | 
|101.DEF** |  | XBRL Taxonomy Extension Definition Linkbase
Document21                                                                                                                                                                                                                   
|          | 
|101.LAB** |  | XBRL Taxonomy Extension Label Linkbase
Document21                                                                                                                                                                                                                        
|          | 
|101.PRE** |  | XBRL Taxonomy Extension Presentation Linkbase
Document21                                                                                                                                                                                                                 



F-27



---



|(1) | Incorporated by reference from the Registrants Registration Statement on Form SB-2 (File No. 33-99386).
|--- | --------------------------------------------------------------------------------------------------------

|(2) | Incorporated by reference from the Registrants Current Report on Form 8-K dated December 27, 2007.
|--- | ---------------------------------------------------------------------------------------------------

|(3) | Incorporated by reference from the Registrants definitive Proxy Statement filed on July 28, 2000.
|--- | --------------------------------------------------------------------------------------------------

|(4) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2001.
|--- | ----------------------------------------------------------------------------------------------------------------

|(5) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2002.
|--- | ----------------------------------------------------------------------------------------------------------------

|(6) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2005.
|--- | ----------------------------------------------------------------------------------------------------------------

|(7) | Incorporated by reference from the Registrants Annual Report on Form 10-KSB for the year ended December 31, 1996.
|--- | ------------------------------------------------------------------------------------------------------------------

|(8) | Incorporated by reference from the Registrants Registration Statement on Form S-3 (File No. 333-42367).
|--- | --------------------------------------------------------------------------------------------------------

|(9) | Incorporated by reference from the Registrants Registration Statement on Form 10.
|--- | ----------------------------------------------------------------------------------

|(10) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2003.
|---- | ----------------------------------------------------------------------------------------------------------------

|(11) | Incorporated by reference from the Registrants Quarterly Report on Form 10-Q for the period ended June 30, 2010.
|---- | -----------------------------------------------------------------------------------------------------------------

|(12) | Incorporated by reference from the Registrants Quarterly Report on Form 10-Q for the period ended September 30, 2010.
|---- | ----------------------------------------------------------------------------------------------------------------------

|(13) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on March 18, 2011.
|---- | ---------------------------------------------------------------------------------------------------

|(14) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on November 17, 2011.
|---- | ------------------------------------------------------------------------------------------------------

|(15) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on December 21, 2011.
|---- | ------------------------------------------------------------------------------------------------------

|(16) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on January 4, 2012.
|---- | ----------------------------------------------------------------------------------------------------

|(17) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2011.
|---- | ----------------------------------------------------------------------------------------------------------------

|(18) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on April 10, 2013.
|---- | ---------------------------------------------------------------------------------------------------

|(19) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on January 2, 2013.
|---- | ----------------------------------------------------------------------------------------------------

|(20) | Incorporated by reference from the Registrants Current Report on Form 8-K/A filed on February 28, 2013.
|---- | --------------------------------------------------------------------------------------------------------

|(21) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2012.
|---- | ----------------------------------------------------------------------------------------------------------------

|* | Confidential treatment has been granted with respect to portions of this exhibit.
|- | ---------------------------------------------------------------------------------

|** | Pursuant to Rule 406T of Regulation S-T, the interactive files on Exhibit 101.1 hereto are deemed not filed or part of a registration statement or prospectus for
purposes of Sections 11 or 12 of the Securities Act of 1933, as amended, are deemed not filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and otherwise are not subject to liability under those sections.
|-- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



F-28



---

SIGNATURES

Pursuant to the requirements of Section 12 of the Securities Exchange Act of 1934, the registrant has duly caused this Annual Report on Form 10-K/A to be signed on its behalf by the undersigned,
thereunto duly authorized.



|                    |  |                             |  |                     
|------------------- |  | --------------------------- |  | --------------------
|Date: July 23, 2013 |  | TITAN PHARMACEUTICALS, INC.
|                    |  |                            
|                    |  | By:                         |  | /S/    SUNIL
BHONSLE
|                    |  | Name:                       |  | Sunil Bhonsle       
|                    |  | Title:                      |  | President           



---

EXHIBIT INDEX

Exhibits



|      |  |                                                                                                                                                                                      
|----- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|No.   |  | Description                                                                                                                                                                          
|      | 
|3.1   |  | Amended and Restated Certificate of Incorporation of the Registrant, as amended9                                                                                                     
|      | 
|3.2   |  | By-laws of the Registrant1                                                                                                                                                           
|      | 
|3.3   |  | Certificate of Designations of Junior Participating Preferred Stock of Titan Pharmaceuticals, Inc.15                                                                                 
|      | 
|4.1   |  | Registration Rights Agreement dated as of December 17, 20072                                                                                                                         
|      | 
|4.2   |  | Registration Rights Agreement dated as of December 8, 20099                                                                                                                          
|      | 
|4.3   |  | Warrant to Purchase Common Stock dated December 23, 2009 issued to Oxford Finance Corporation9                                                                                       
|      | 
|4.4   |  | Form of Warrant13                                                                                                                                                                    
|      | 
|4.5   |  | Registration Rights Agreement, dated as of March 15, 201113                                                                                                                          
|      | 
|4.6   |  | Form of Series A Warrant18                                                                                                                                                           
|      | 
|10.1  |  | 1998 Stock Option Plan3                                                                                                                                                              
|      | 
|10.2  |  | 2001 Non-Qualified Employee Stock Option
Plan4                                                                                                                                       
|      | 
|10.3  |  | 2002 Stock Option Plan5                                                                                                                                                              
|      | 
|10.4  |  | Employment Agreement between the Registrant and Sunil Bhonsle, dated May 16, 2009, as amended by agreements dated February 17, 2010, December 30, 2011 and December 31,
20129, 16, 19
|      | 
|10.5  |  | Employment Agreement between the Registrant and Marc Rubin, dated May 16, 2009, as amended by agreements dated February 17, 2010, December 30, 2011 and December 31, 2012,9 16, 19   
|      | 
|10.6  |  | Lease for the Registrants facilities, amended as of October 1, 20046                                                                                                                
|      | 
|10.7  |  | Amendments to lease for Registrants facilities dated May 21, 2007 and March 12, 20099                                                                                               
|      | 
|10.8* |  | License Agreement between the Registrant and Sanofi-Aventis SA effective as of December 31, 19967                                                                                    
|      | 
|10.9* |  | Sublicense Agreement between the Registrant and Novartis Pharma AG dated November 20, 19978                                                                                          
|      | 
|10.10 |  | Loan and Security Agreement between the Registrant and Oxford Finance Corporation dated December 18, 20099                                                                           
|      | 
|10.11 |  | Stock Purchase Agreement between the Registrant and certain investors dated December 8, 20099                                                                                        
|      | 
|10.12 |  | Amendment to Employment Agreement dated June 15, 2010 between the Registrant and Marc Rubin10                                                                                        
|      | 
|10.13 |  | Amendment to Employment Agreement dated June 15, 2010 between the Registrant and Sunil Bhonsle10                                                                                     
|      | 
|10.14 |  | Amendment to lease for Registrants facilities dated June 15, 201011                                                                                                                 
|      | 
|10.15 |  | Amended and Restated Loan and Security Agreement between the Registrant and Oxford Finance Corporation dated September 27, 201012                                                    



---

|          |  |                                                                                                                                                                                                                                                                          
|--------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|No.       |  | Description                                                                                                                                                                                                                                                              
|          | 
|10.16     |  | Facility Agreement, dated as of March 15, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Private Design International II, L.P., Deerfield
Special Situations Fund, L.P., and Deerfield Special Situations Fund International Limited13
|          | 
|10.17     |  | Security Agreement, dated as of March 15, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Private Design International II, L.P., Deerfield
Special Situations Fund, L.P., and Deerfield Special Situations Fund International Limited13
|          | 
|10.18     |  | Royalty Purchase Agreement, dated November 14, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Special Situations Fund, L.P. and Horizon Sante
TTNP SARL14                                                                             
|          | 
|10.19     |  | Amended and Restated Royalty Agreement, dated November 14, 2011 by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Special Situations Fund, L.P. and
Horizon Sante TTNP SARL14                                                                  
|          | 
|10.20     |  | Amended and Restated Royalty Repurchase Agreement, dated November 14, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., and Horizon Sante TTNP SARL14                                                                                              
|          | 
|10.21     |  | Cash Management Agreement, dated November 14, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Special Situations Fund, L.P. and Horizon Sante
TTNP SARL14                                                                              
|          | 
|10.22     |  | Paying Agent Agreement, dated November 14, 2011, by and among the Company, Deerfield Management Company, L.P. and U.S. Bank National Association14                                                                                                                       
|          | 
|10.23     |  | Agreement, dated as of November 14, 2011, by and among the Company, Deerfield Private Design Fund II, L.P., Deerfield Private Design International II, L.P., Deerfield Special
Situations Fund, L.P., and Deerfield Special Situations Fund International Limited14      
|          | 
|10.24     |  | Form of Subscription Agreement dated April 9,
201218                                                                                                                                                                                                                     
|          | 
|10.25*    |  | License Agreement by and between Titan Pharmaceuticals, Inc. and Braeburn Pharmaceuticals Sprl, dated December 14, 201220                                                                                                                                                
|          | 
|14.1      |  | Code of Business Conduct and Ethics21                                                                                                                                                                                                                                    
|          | 
|23.1      |  | Consent of OUM & Co., LLP, Independent Registered Public Accounting Firm                                                                                                                                                                                                 
|          | 
|31.1      |  | Certification of the Principal Executive and Financial Officer pursuant to Rule 13(a)-14(a) of the Securities Exchange Act of 1934                                                                                                                                       
|          | 
|32.1      |  | Certification of the Principal Executive and Financial Officer pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002                                                                                                          
|          | 
|101.INS** |  | XBRL Instance Document21                                                                                                                                                                                                                                                 
|          | 
|101.SCH** |  | XBRL Taxonomy Extension Schema
Document21                                                                                                                                                                                                                                
|          | 
|101.CAL** |  | XBRL Taxonomy Extension Calculation Linkbase
Document21                                                                                                                                                                                                                  
|          | 
|101.DEF** |  | XBRL Taxonomy Extension Definition Linkbase
Document21                                                                                                                                                                                                                   
|          | 
|101.LAB** |  | XBRL Taxonomy Extension Label Linkbase
Document21                                                                                                                                                                                                                        
|          | 
|101.PRE** |  | XBRL Taxonomy Extension Presentation Linkbase
Document21                                                                                                                                                                                                                 



|(1) | Incorporated by reference from the Registrants Registration Statement on Form SB-2 (File No. 33-99386).
|--- | --------------------------------------------------------------------------------------------------------

|(2) | Incorporated by reference from the Registrants Current Report on Form 8-K dated December 27, 2007.
|--- | ---------------------------------------------------------------------------------------------------

|(3) | Incorporated by reference from the Registrants definitive Proxy Statement filed on July 28, 2000.
|--- | --------------------------------------------------------------------------------------------------

|(4) | Incorporated by
reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2001.
|--- | ----------------------------------------------------------------------------------------------------------------



---

|(5) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2002.
|--- | ----------------------------------------------------------------------------------------------------------------

|(6) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2005.
|--- | ----------------------------------------------------------------------------------------------------------------

|(7) | Incorporated by reference from the Registrants Annual Report on Form 10-KSB for the year ended December 31, 1996.
|--- | ------------------------------------------------------------------------------------------------------------------

|(8) | Incorporated by reference from the Registrants Registration Statement on Form S-3 (File No. 333-42367).
|--- | --------------------------------------------------------------------------------------------------------

|(9) | Incorporated by reference from the Registrants Registration Statement on Form 10.
|--- | ----------------------------------------------------------------------------------

|(10) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2003.
|---- | ----------------------------------------------------------------------------------------------------------------

|(11) | Incorporated by reference from the Registrants Quarterly Report on Form 10-Q for the period ended June 30, 2010.
|---- | -----------------------------------------------------------------------------------------------------------------

|(12) | Incorporated by reference from the Registrants Quarterly Report on Form 10-Q for the period ended September 30, 2010.
|---- | ----------------------------------------------------------------------------------------------------------------------

|(13) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on March 18, 2011.
|---- | ---------------------------------------------------------------------------------------------------

|(14) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on November 17, 2011.
|---- | ------------------------------------------------------------------------------------------------------

|(15) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on December 21, 2011.
|---- | ------------------------------------------------------------------------------------------------------

|(16) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on January 4, 2012.
|---- | ----------------------------------------------------------------------------------------------------

|(17) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2011.
|---- | ----------------------------------------------------------------------------------------------------------------

|(18) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on April 10, 2013.
|---- | ---------------------------------------------------------------------------------------------------

|(19) | Incorporated by reference from the Registrants Current Report on Form 8-K filed on January 2, 2013.
|---- | ----------------------------------------------------------------------------------------------------

|(20) | Incorporated by reference from the Registrants Current Report on Form 8-K/A filed on February 28, 2013.
|---- | --------------------------------------------------------------------------------------------------------

|(21) | Incorporated by reference from the Registrants Annual Report on Form 10-K for the year ended December 31, 2012.
|---- | ----------------------------------------------------------------------------------------------------------------

|* | Confidential treatment has been granted with respect to portions of this exhibit.
|- | ---------------------------------------------------------------------------------

|** | Pursuant to Rule 406T of Regulation S-T, the interactive files on Exhibit 101.1 hereto are deemed not filed or part of a registration statement or prospectus for
purposes of Sections 11 or 12 of the Securities Act of 1933, as amended, are deemed not filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and otherwise are not subject to liability under those sections.
|-- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------