# &EPA

Agrobacterium radiobacter 

# strains K84/Kerr-84 and K1026 Final Registration Review Decision

Registration Review Case 4101 Docket Number EPA-HQ-OPP-2009-0878

Approved By:

. Matthews, Director Biopesticides and Pollution Prevention D ivisionRegistration Review Agrobacterium radlobacterstralns K84/Kerr-84 and K1026 Final Registration Review Decision Reg istration Review Case 4101 Docket Number : EPA-HQ-OPP-2009-0878



### TABLE OF CONTENTS Agrobacterium radiobacter 

### Registration Review Team......................................... 3 I. 

### Introduction..........
. ......... .. . .... . ....... .. .. . . .. . ........... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... 4 A. Agrobacterium radiobacter 

### General Background...
. . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . 5 B
. Agrobacterium radiobacte r 

### Registered Pesticide Products
.. . .. . .. .. . ................... 5 II. Scientific Assessment
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 A. Product Analys is Data......
. ..... . .......... . .. . .......................... . ..... .. ....... 6 B. Human Health Data and Risk Assessment.........
. . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 C. Nontarget Organisms Data and Ecological Risk Assessment..................
. .. . 7 D. Product Performance
. .. . .. . .. .. . .. . .. . . . . .. . ...................................... . ..... 7 E. Inc idents....
. ............ ................... .. . ...................................... . ...... 8 F. Public Comments .. .... .. . ............. ........................................ . ......... . G. Water Qualit y .......................... ..... ............................................. . H. Trade Irritants ............ .. . ................ ....... ........ .................................. .. .. . I. 

### Envirorunental Justice
............................................... . .. . .. . .. . ........... . III. Final Registratio n Review Dec ision
.. . .. .... .. ... ............................................ . . IV. Next Steps
................................. .. :. . . .. . .. ............................................... . V. Glossary of Terms and Abbreviations
........................................................ . VI. Bibli ography
..................... .. .. . . . .. .. . .. . .. ........................................... . .. .

2 8 

### 9 9 9 

### 9 10 ll 12Registration Review Agrobacterium radlobacterstrains K84/Kerr-84 and K1026 Final Registration Review Decision Registration Review Case 4101 Docket Number: EPA-HQ-OPP-2009-0878 

### Agrobacterium radiobacter 

### Registration Review Team Product Characteriza tion and Human Health Joel Gagliardi, Ph .D. Environmental Effects Shannon Borges, M.S. Risk Management Ann Sibold , M.A. Office of General Counsel Philip Ross , Esq. Chris Kaczmarek, Esq.

3Registration Review Agrobacterium radiobacterstrains K84/Kerr-84 and K1026 Final Registration Review Decision Registration Review Case 4101 Docket Number: EPA-HQ-OPP-2009 -0878 

### I. 

### INTRODUCTI ON This document is the Environmental Protection Agency's (EPA or the Agency) Final Registration Review Decision for Agrobacterium radiobacter (Hereafter referred to as A. radiobacter) strains K84/Kerr-84 and K1026. It is being issued in accordance with 40 CFR 

### §§ 155
. 57 and 155.58. A final registration review decision is the Agency's determination whether a pesticide meets , or does not meet, the standard for registration in the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). Information on A. radiobacter strains K84/Kerr84 and K1 026 can be found in EPA's public docket (EPA-HQ

- OPP-2009-0878) at www.regulations.gov
. FIFRA , as amended by the Food Quality Protection Act (FQPA) of 1996, mandated the continuous review of existing pesticides. All pesticides distributed or sold in the United States must generally be registered by EPA, based on scientific data showing that they will not cause unreasonable risks to human health or the en v ironment when used as directed on product labeling. The registration review program is intended to make sure that , as the ability to assess risk evolves and as policies and practices change, all registered pesticides continue to meet the statutory standard of no unreasonable adverse effects to human health or the environment. Changes in science, public poli cy, and pestic ide use practices will occur over time. Through the registration review program, the Agency periodically reevaluates pesticides to make sure that as change occurs, products in the marketplace can b e used safely. Information on this program is provided at: http: //www.epa. govIoppsrrd 1/registration review /. In 2006, the Agency implemented the Registration Review program pursuant to Section 3(g) of FIFRA and , as required, will review each regi stered pesticide every 15 years to determine whether it continues to meet the FIFRA standard for re gis tration. In accordance with 40 CFR 

### § 155.50, the Agency formally initiated registration review for A. radiobacter strains K84/Kerr-84 and K 1026 (Case 4101 ). The following timeline highligh ts significant events that have occurred during the registration review of A. radiobacter strains K84/Kerr-84 and K1026:

• March 201 0

- Publication of the A. radiobacter strains K84/Kerr-84 and K 1026 Summary Document, containing a Pre liminary Work Plan (PWP) and Fact Sheet, in docket EPA

-HQ-OPP-2009-0878 for a 60 day comment period. No comments were received. • August 31, 2010

- Publication ofthe A
. radiobacter strains K84/Kerr-84 and K 1026 Final Work Plan, which stated that the most recent exposure and risk assessments still support the registration of pesticide products containing A. radiobacter strains K84/Kerr-84 and Kl 026 and meet the requirements of Registration Review under 40 CFR 

### § 155.50. • July 11, 2012

- Publi cation of the A. radiobacter strains K84 /

Kerr-84 and Kl 026 Registration Review Proposed Decision , which maintained that the available risk assessments still supported t he registration of pesticide products containing A. radiobacter strains K84/ Kerr-84 and K 1026. This document was issued in C()njunction with the opening of a public comment period. During the comment period, the Agency**r~ceived** no comments from the public. •

### September~**~Q 12-**  Isstiance o f this document , the A. radiobacter strains K84/Kerr-84 and Kl 026 Final

### Registra~hilf 

### R?Y(ew**D~cision.** : . . . On October 26,**9Q ~** **th ~**  Agency promulgated a Final Rule setting forth the data requirements to support registration**of'bi 8.P.** **hl?,rn!~a 1** **~4 ri1icro~ial**  pesticides and updated defmitions for both biochemical and microbial pesticides (72**J::~** 

# M**Q02) ~** **'fhi~** fjlle pecame effective on December 26, 2007. The data and information**summarizedJhf<:)llgh Q~f** **~~~ d9cume.pt**  were considered in li ght ofthese requirements. :; .**.,** ' . . . . . . 4Registration Review Agrobacterium radiobacterstrains K84/Kerr-84 and K1026 Final Registration Review Decision Registration Review Case 4101 Docket Number: EPA-HQ·OPP-2009-0878
The data and information evalu ated to support A. radiobacter s trains K84/Kerr-84 (hereafter referred to as K84) and K1026, as published in the Summary Docume nt dated March 29,2010, continue to support the pesticide registration as summarized herein. The status of this and other registration review cases is available on httpl l www.epa.gov /

oppsrrdll registration review /review status . htm
. 

### A. A. radiobacter 

### strains K84 and K1026 General Background. A. radiobacter is a naturally occurring soil bacterium presen t in many soi l types and plant rhizospheres (zones of soil surrounding plant roots , influenced by root secretions and increased microbial growth and activity) worldwide. The Agency has classified two strains of A. radiobacter , K84 and Kl 026, as microbial pes ticides; both strains are included in this Registration Review case. These pesticide products contain living A. radiobacter as the active ingredient. When used as a microbial pest control agent in seed, root, and stem treatments ofnonbearing fru it, nut, and ornamental plants , A. radiobacter is intended to protect them from Crown Gall , which is caused by the plant pathogen, Agrobacterium tumefaciens (A. tumefaciens)
. B oth strains of A. radiobacter control A
. tumefaciens through direct competition , which is primarily accomplished by the production of agroci n 84 , a bacteriocin produced by both A. radiobacter strain K84 and strain K 1026 that is specific for certain pa thogenic strains of Agrobacterium spp. Bacteriocins are peptides that are produced by certain bacteria and are known to inhibit the growth of other bacteria. A. radiobacter strain K84 is nonpathogenic and naturally occurring. It was discovered as a natural inhibitor of A. tumefacien s. 

### 1n some cases, conjugal transfer of the plasmid encoding agrocin 84 production may occur between A. radiobacter strain K84 and some strain s ofA. tumefaciens. (A plasmid is a DNA molecule that is separate from , and can replicate independently of , the chromosomal DNA.) Thi s transfer can result in reduced biocontrol effectiveness because genes determining immunity to agrocin 84 are also on the plasmid encoding its production. A. radiobacter strain K 1 026 is a derivative of the K84 strain and was developed to counteract the potential for development of resistant strains of A. tumefaciens. It is derived by t he deletion of the genetic material that i s necessary for the transfer of immunity to agrocin 84. A. radiobacter strains K84 and K1026 were derived from the same i sola te, though they were developed for pest i cidal use several years apart. Biochemica l testing conducted for pesticide registration of K 1 026 shows the two strains are identical except for the intentional modifications made to the plasmid in K 1026. 

### B. Registered Products. A. radiobacter strain K-84 was first regist ered in 1979 as Galltrol-A, EPA Reg. No. 40230-1, for u se in the prevention of Crown Gall infection s in certain fruit, nut and ornamental nursery stock (non-bearing plants only). A. radiobacter strain K 1 026 was first registered conditionally in September 1999 under the pro duct name Nogall , E PA Reg. No. 62388 -1.



### 5Registration Review Agrobacterlum radiobacter strains K84/Kerr-84 and K1026 Final Registration Review Decision Registration Review Case 4101 Docket Number: EPA
- HQ
-OPP-2009-0878


### II. SCIENTIFIC ASSESSMENT A. Product Analysis Data (40 CFR 

### § 158.2120). All product analysis data requirements at 40 CFR 158.2120 have been satisfied for A. radiobacter strain K84 and A. radiobacter strain K 1026. Assessments of these data s how that they continue to meet the standard for registration under FIFRA, as amended by FQPA. No further product analysis data are required. Please refer to th e Summary Document posted in the initial docket (EPA-HQ-OPP-2009- 0878) for a more detailed discussion. 

### B. Human Health Data (40 CFR 

### § 158.2140) and Risk Assessment. 1. 

### Human Health Data 

### and Risk Assessment. All human health data requirements at 40 CFR 158.2140 have been fulfilled for both strains ofA. radiobacter. The Summary Document posted in the initial docket (EPA-HQ-OPP-2009-0878) provides a detailed discussion of the human health data and risk assessment status. 

### 2
. Endocrine Disruptors
. Pursuant to the requirements of Section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA), EPA developed an Endocrine Disruptor Screening Program (EDSP) to be used to determine whether certain chemicals, such as pesticide active and inert ingredients, may have an effect in humans or wildlife similar to an effect produced by a " naturally occurring estrogen, or such other endocrine effect as the Administrato r may designate." Section 408(p )(

4) ofthe FFDCA authorizes EPA, by order, to exempt from the requirements ofthe endocrine screening program required by Section 408(p)(l) "a biologic substance or other substance ifthe Administrator determines that the substance is anticipated not to produce any effect in humans similar to an effect produced by a naturally occurring estrogen." EPA has evaluated A. radiobacter stra ins K84 and K 1026 , the active ingredient involved in Registra tion Review Case 4101 (Docket Number EPA-HQ-OPP-2009-0878]. Based on the analysis and rationale that are described in the Administrative Order, "Exemption of Agrobacterium radiobacter st rains K84 and K1026 from the Requirements ofthe Endocrine Disruptor Screening Program," (EDSP) signed June 4, 2012, EPA has determined that A. radiobacter is a "biologic substance," and that neither the microorganisms nor the adenine bactericidal compound (agrocin 84) they produce are anticipated to produce in humans or any other organism an effect similar to that produced by a naturally occurring estrogen, androgen, or thyroid hormone. Pursuant to Section 408(p )(

4), EPA has exempted A. radiobacter strains K84 and K1026 from the requirements ofthe EDSP. A copy ofthis Administrative Order (U.S. EPA
. 2012) is included in Docket Number EPA-HQ-OPP-2009-0878. 

### For further informat ion on the stat us of the EDSP, 

### the policies and procedures, the list of 67 chemicals , future lists , the test guidelines and the Tier 1 screening battery, please visit our webs ite: http: / /www .epa.gov/endo/
. 

### 6Registration Review Agrobacterium radiobacterstrains K84/Kerr-84 and K1026 Final Registration Review Decision Registration Rev iew Case 4101 Docket Number: EPA-HQ-OP P-2009-0878


### C. Nontarget Organisms Data (40 CFR 

### § 1 58.2150) and Ecological Risk Assessment. 1. 

### Effects on Nontarget Organisms: Data (40 CFR 

### § 158.2150) and Env ironmental Risk Assessment. All nontarget tox icity data requirements at 40 CFR 158.2150 have been fulfilled and meet the standard for registration required under FIFRA for both strains of A. radiobacter. Please refer the Summary Document posted in the injtial docket (EPA-HQ-OPP-2009-0878) for a more detailed discussion. 

### 2
. Endangered Species Assessment. The final work plan stated that the Agency wo uld complete a risk assessment that supports a complete endangered species determination for both strains of A. radiobacter. The endangered species asses sment has been completed, and the results of that assessment follow. " Exposure to nontarget organisms i s expected to be very limited due to the labeled use patterns and application methods. A. radiobacter i s also specific for the target pest and is not known or expected to be infective or to cause toxicity and pathogenicity in nontarget organisms. Additionally , no incidents of adverse effects to nontarget species have been reported to the Agency. The Agency concluded in its scoping document that adverse effects to avian wildlife, wild mammals , nontarg et insects, honey bees, freshwater and marine/estuarine fish and invertebrate s, and nontarget plants are not expected as a result of the labeled uses ofA. radiobacter strain K84 or A. radiobacter K 1 026. A. radiobacter strain K84 and A. radiobacte r strain K I 026 have been shown to return to naturally occurring population levels after application , and will not occur outside of the immediate area around treated plants at higher populations than those of naturally occurring A. radiobacter." (USEPA, 2011). Since EPA has determined that no effects are anticipated for any non-target sp ecies exposed to A. radiobacter strain K84 and A
. radiobacter strain K 1026 as a result of the labeled applications, effects to threatened and endangered species and their des ignated critical habi tats are also not expected. Therefore, a "No Effect" determination is proposed for direct and indirect effects to listed species and their designated critical habitats resulting from the regi stered uses of A. radiobacter st r ain K84 and A. radiobacter strain K1 026, as l abeled. (USEPA , 2011 ). Please refer the Endangered Species Assessment, which has been posted in the docket (EPA-HQ-OPP

- 2009- 0878) , for a more detailed discussion {USEPA, 2011 ). 

### D. Product Performance (Efficacy) Data (40 CFR § 158.2160). Product performance data must be developed for all microbial pesticides to ensure efficacy when used in accordance with labeling directions and commonly accepted pest control practices. The Agency h as waived all requirements to subm it such efficacy data unless the pesticide product bears a claim to control public health pests, although the Agency reserves the right to require , on a case-by-case basis , submission of efficacy data for any pesticide product registered or proposed for registration. A. radiobacter strain K84 and A. radiobacter strain K 1026 pesticide products are registered for use for treating seeds, roots , and stems of nonbearing fruit, n ut, and ornamental


### 7Registration Rev i ew Agrobacterium radiobacter strains K84/Kerr-84 and K1026 Final Registration Review Decis i on Registration Review Case 4101 Docket Number: EPA-HQ
-OPP-2009·0878 plants . These products do not have labeled uses for public health pests; therefore the Agency has not required submission of efficacy data to support their label cla ims . 

### E
. Incidents The Summary Document dated March 2010 and posted in the initial docket (EPA

-HQ-OPP2009

-0878), stated that no incidents had been reported for current ly registered products containing A. radiobacter as an active ingredient for the current use patterns
. Please refer the Summary Document for a more detailed discussion. Since the Summary Document was posted, EPA initiated a more recent search for incidents reported to the Agency for A
. radiobacter and filed in EPA's Incident Data System (IDS). EPA searched IDS for the time period extending from 0110111979, (when A. radiobacter was first regis tered as a pesticide) to 01/14/2012. The Agency found one report, filed in IDS on 1/112010, of an alleged relation of Agrobacterium to Morgellons disease. EPA has looked into this incident report, and notes that the Morgellons Research Foundation has suggested that unidentified species and strains ofAgrobacterium spp. were responsible, at least in part, for a dermatopathology in humans. This pathology included incidents of skin rash, pruritis, hair loss and fatigue, among other maladies presented. EPA further notes that a study was initiated in 2007 by the Center for Disease Control (CDC) o f the U
.S
. Department of Health and Human Services and Kaiser-Permanente. Thi s study evaluated patients in Ca lifornia, who indicated that they had been suffering from an apparently similar dermopathy. The CDC study indicated that there was no common underlying disease or infectious agent identifiable in the 115 patients they examined (Pearson et al , 20 12). The lack of identification of Agrobacterium spp. or other readily culturable bacterial species from skin and b lood of study patient$ strongly suggests that whatever the cause of this disease may be, it is not linked to the presence of Agrobacterium radiobacter or other re lated species (e
. g., A
. tumefaciens, A. rhizogenes). A copy of this review has been placed in the docket. EPA concludes that no revision to the human health risk assessment to address Morgellons disease is needed, based on the review of the incident report described in the previous paragraph, and further, that no additional action is needed at this time. 

### F
. Public Comments In accordance with 40 CFR 

### § 155.50, the Agency formally initiated registration review for A. radiobacter on March 31, 2010, with the opening of a docket (EPA

-HQ

- OPP-2009

-0878) and the publication of a Summary Document for a 60-day public comment period. The Agency received no comments on the Summary Document for A. radiobacter during the 60

- day public comment period that ended on June 1, 2010. The A
. radiobacter Final Work Plan was placed into the docket on August 31, 2010. The Agency received no comments. The Notice announcing the proposed final decision for Agrobacterium radiobacter strains K84/ Kerr-84 and K1026 on was issued on July 11 , 2012. Agency received no comments during the comment period which closed September 10, 2012.


### 8Registration Review Agrobacterlum radiobacterstrains K84/Kerr-84 and K1026 Fin al Registration Review Decision Registration Review Case 4101 Docket Number: EPA-HQ-OPP-2009-0878 

### G
. Water Quality In the Summary Document for A. radiobacter, EPA noted that A. radiobacter was n ot identified as a cause of impairment for any li s ted water bodies, and no Total Maximum Daily Load s (TMDL) were developed for A. radiobacter. The Agency solicited comments when the Summary Document was published in March 20 I 0 ; however, no comments, data, o r information re ga rdin g the existence of any water quality issues assoc iated with A. radiobacter were received. 

### H. Trade Irritants Through the registration review proce ss, the Agency is soliciting information on trade irritants and , to the extent feasib le , will take steps toward faci litat ing irritant re so lution. Growers and ot

her stakeholders were asked to comment on any trade irritant issues resulting from lack of Maximum Residue Levels (MRLs) or disparities between U.S. tolerances or exemptions from tolerance and MRLs or exemptions from MRLs in key export markets , pro viding as mu ch specificity as possible regarding the n ature of the co ncern. 

### In the Summary Document f orA
. radiobacter , EPA noted that there are no registered food uses or re sidue tolerances established for A. radiobacter. The Agency did not receive any comments regarding the existence o f any trade irritant issues associated with A. radiobacter fo llowing publication of the Summary Document. 

### I. Environmental Justice EPA seeks to achieve environmental j ustice-the fair trea tment and meaningful involvement of all people , regardless of race, color, national origin, or income

- in the dev elopment, implementation , and enforcement of e nvironmental laws, regulations , and po licies. To he lp address potential e nvironmen tal justice issues, the Agency sought information, as explained in the Summary Document, on groups or segments ofthe population who, as a res ult oftheir location , cultural practices, or other factors, may have atypical , unusually high exposure to reg is tered pesticid e products containing A. radiobacter compared to the general population. The Agency did not receive any comments. At this time, EPA does not believe that use of the registered pestic ide products containing A. radiobacter will cause harm to or have a disproportionate impact on at-r isk communities. For additional information regarding environmental justice iss ues, p lease vis it EPA ' s website at: http: // www.epa. go vIcompliance /environmentaljustice /index.htrnl
. 

### III. FINAL REGISTRATION REVIEW DECISION The Agency has determined that no additional data are required at this time to support registrations containing A
. radiobacter. T he Agency has co nsidered A. radiobacter in light ofthe standard for re gistra tion and safety factors in FIFRA and FFDCA , as amended by FQPA
. EPA has found that there are not likely to be any unreasonable adverse effects to the U.S. population in general , and to infants and children 

### in particular, or to nontarget organisms or the environment from the use of registered pesticide products containing A. radiobacter when currently required lab e l in structions are followed. In addition, EPA has made a "No Effect" determination for endangered and threatened spec ies , and their de signated critical habitat , for A. radiobacter. The Agency h as 

### 9Registration Review Agrobacterium radiobacterstrains K84/Kerr-84 and K1026 Final Registration Review Decision Registration Review Case 4101 Do cket Number: EPA
- HQ -OPP-2009-0878 further determined that A. radiobacter strain K84 and A. radiobacter strain K 1 026 qualify for exemption from the requirement for testing in the EDSP. Accordin gly, EPA lhas, pursuant to FFDCA Section 408(p)(4), i ss ued an order exempting A. radiobacter stra in K84 and A. radiobacter strain K 1026 from the requirements of the E DSP. The Agency has found that it is not necessary to conduct a new risk assessment for this case and i s therefore issuing a final registration review decision in accordance with 40 CFR Section 155.53(c)(2) and 40 CFR Section 155.58. Therefore, in accordance with 40 CFR 

### §§ 155.57 and 15 5.5 8 , the Agency's final regis tration review deci s ion is that the standards for Regi stration Review have been met and that the registrations of the two products containing A. radiobacter may be maintained. 

### IV. NEXT STEPS In accordance with 40 CFR 

### § 155.58 , the Agency is issuing this final registration review decision document and placing it in the A. radiobacter registration review docket (EPA-HQ -OPP-2009-0878). A Federal Register N otice will announce its availability.

10Registration Review Agrobacterium radiobacterstrains K84/Kerr-84 and K1026 Final Registration Review Decision Registration Review Case 4101 Docket Number: EPA-HQ-OPP-2009-0878 

### V. GLOSSARY of 

### TERMS & 

### ABBREVIATIONS BPPD CBI CFR ECso EDSP EP EPA FESTF FFDCA FIFRA FQPA FR FWP MPs MRIDNo. MRLs NOEL OCSPP OPP PC Code PWP TGA is TMDLs U.S. Biopesticides and Pollution Preventi on Di vi s i on Confidential business infonnation Code of Federal Regulations Half maximal effective concentration Endocrine Disruptor Screening Program End-use product Environmental Protection Agency (the Agency) FIFRA En dan gered Species Task Force Federal Food, Drug, and Cosmetic Act Federal Insecticide, Fungicide , and Rodenticide Act Food Quality Protection Act Federal Register Final Work Plan Manufacturing

- use products Master Record Identification Number
. (EPA's system ofrecording and tracking submitted studies .) Maximum Residue Levels No observable effect level Office of Chemical Safety and Pollution Prevention Office of Pesticide Programs Pesticide Chemical Code Preliminary work plan Technical grade of the active ingredients Total Maximum Daily Loads United States

11Registration Review Agrobacterium radiobacter strains K84/Kerr-84 and K1026 Final Registration Review Decision Registration Review Case 4101 Docket Number: EPA-HQ -O PP
-2009 -0878 

### VI. BIBLIOGRAPHY EPA Re views U.S. EPA, 2011. Memorandum from Shannon Borges to Ann Sibold. Endangered Species Assessment for Regi stration Review of Agrobacterium radiobacter strain K84 a nd Agrobacterium radiobacter strain K 1 026. U.S. Environmental Protection Agency Office ofPesticide Programs. February 18,2011. U.S. EPA. 2012. Administrative Order signed by Jam es J. Jones, June 4, 20 12. Exemption of Agrobacterium radiobacter s train s K84 and K 1026 from the Requirements of the Endocrine Disrupter Screening Program. U.S. E PA. 2012. Memo from Chris Wozniak, Ph.D. dated 9/21/2012. Co mments on incident report for A. radiobacte r (02156 3 00001) of 01/011201 0; Agrobacterium radiobacter st rain K84 and related agrobacteria. Public Literature Pearson ML , Selby JV , Katz KA, Cantrell V, Braden CR , et al. (2012) C linical , Epidemiologic , His topathologic and Molecular Features of an Unexplai ned Dermopathy. PLoS ONE 7(1): e29908. doi: 1 0.1371/journal
.pone.0029908. Available at: http: // www.plosone
.org/ar ticle/info%3Adoi%2Fl0.137 1 %2Fjourna1.pone.0029908

12