**EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR PESTICIDE**

**PETITIONS PUBLISHED IN THE FEDERAL REGISTER EPA Registration Division contact:**  **[P.V. Shah, 703 -** **308 -**  **1846]**

**INSTRUCTIONS: Please utilize this outline in preparing the pesticide petition. In cases**  **where the outline element does not apply, please insert “NA -**  **Remove” and maintain the outline. Please do not change the margins, font, or format in your pesticide petition. Simply**  **replace the instructions that appear in green**  **, i.e., “ [insert company name]**  **,” with the information specific to your action**  **[Joint Inerts Task Force, Cluster Support Team 2 (JITF CST2)] [2E8092]**  EPA has received a pesticide petition **(2E8092)** from **[ Joint**  **Inerts Task Force, Cluster Support Team 2, EPA Company Number 84914**  **], [ c/o Huntsman Corp., 8600 Gosling Rd.,**  **The Woodlands, TX 77381 ]**  proposing, pursuant to section 408(d) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 4 0 CFR part 180. To amend existing exemptions from the requirement of a tolerance **[by addin**  **g Chemical**  **Abstracts Service Registry Numbers (**  **CASRNs )**  **for p ost** **- harvest use on agricultural crops**  **under 40 CFR §180.9 1**  **0 and when applied to animals under 40 CFR §180 .930 for the**  **following two chemistry descriptors that are used as surfactants not to exceed 30% of**  **pesticide formulation :**  **Alkyl Alcohol Alkoxylate Phosphate and Sulfate Derivatives (AAAPD and AAASD respectively), including:**  **AAAPD Surfactants: 40 CFR §180**  **.910 and §180.930: α -** **Alkyl (minimum C 6**  **linear or branched, saturated and or unsaturated)**  **- ω**  **- hydroxypolyoxyethylene polymer with or without polyoxypropylene,**  **mixture of di -**  **and monohydrogen phosphate esters and the corresponding ammonium, calcium, magnesium,**  **monoethanolamine, potassium, sodium, and zinc salts of the phosphate esters; minimum oxyethylene content averages 2 moles; minimum oxypropylene**  **content is 0 moles; used as surfactants not to exceed 30% of pesticide formulation. CASRN**  **AAAPD Chemical Name 103170**  **- 31**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C8 -**  **10 -**  **alkyl ethers, phosphates, potassium salts**  **103170 -** **32 -**  **7 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , monococo alkyl ethers,**  **phosphates, potassium salts 106233**  **- 09**  **- 4**  **Alcohols, C16 -**  **18, eth oxylated, phosphates**  **106233 -**  **10 -**  **7 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C12**  **- 20**  **- alkyl ethers,**  **phosphates 1072943**  **- 56**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C11**  **- 14**  **- isoalkyl ethers,**  **C13 -**  **rich, phosphates, sodium salts 110392**  **- 49**  **- 9**  **Alcohols, C9 -**  **11, ethoxylated, phosphated, sodium salt CASRN**  **AAAPD Chemical Name**

**111798 -**  **26 -**  **6 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- (2**  **- ethylhexyl)**  **- w**  **- hydroxy** **- , phosphate,**  **Na salt**  **111905 -**  **50 -**  **1 Alcohols C16**  **- 18, ethoxylated, phosphated, potassium salt**  **116671 -**  **23 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- hydroxy** **- , di** **- C12**  **- 14**  **- alkyl**  **ethers, sodium salts 117584**  **- 36**  **- 8**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a' -**  **phosphinicobis[w -**  **hydroxy -**  **, di -**  **C12 -**  **15 -**  **alkyl ethers**  **1187742 -**  **89 -**  **7 Alcohols C16**  **- 18 and C18 unsatured, ethoxylated (2 EO), phosphate salt**  **1187743 -** **35 -**  **6 Alcohols, C16**  **- 18 and C18**  **- unsatd., ethoxylated, phosphate, potassium salt**  **119415 -**  **05 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C16**  **- 20**  **- alkyl ethers,**  **phosphates, sodium salts 121158**  **- 61**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a' -**  **phosphinicobis[w -**  **hydroxy -**  **, d i** **- C12**  **- 14**  **- alkyl**  **ethers 121158**  **- 63**  **- 2**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **hydroxy -**  **, C12 -**  **14 -**  **alkyl ethers 125139**  **- 13**  **- 1**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **hydroxy -**  **, C14 -**  **18 -**  **alkyl ethers 125301**  **- 86**  **- 2**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **hydroxy -**  **, C6 -**  **1 0**  **- alkyl ethers**  **125301 -**  **87 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- phosphono**  **- w**  **- hydroxy** **- , C10**  **- 14**  **- alkyl ethers,**  **potassium salts 126646**  **- 03**  **- 5**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C10 -**  **14 -**  **alkyl ethers, phosphates, potassium salts**  **129870 -**  **77 -**  **5 Oxirane,**  **methyl -**  **, polymer with oxirane, mono(C13 -**  **15 -**  **branched and linear alkyl) ethers, phosphates**  **129870 -**  **80 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- phosphono**  **- w**  **- hydroxy** **- , C10**  **- 14**  **- alkyl ethers,**  **disodium salts 130354**  **- 37**  **- 9**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C12 -**  **13 -**  **alkyl ethers, phosphates, sodium salts**  **136504 -**  **88 -**  **6 Poly(oxy**  **- 1,2**  **- ethanediyl), .alpha.**  **- hydro**  **- .omega.**  **- hydroxy** **- , mono**  **- C9**  **- 11**  **- alkyl**  **ethers, phosphates 143372**  **- 50**  **- 3**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a' -**  **phosphinicobis[w -**  **hydroxy -**  **, di -**  **C13 -**  **15 -**  **alkyl ethers, ammonium**  **salts 143372**  **- 51**  **- 4**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **hydroxy -**  **, C13 -**  **15 -**  **alkyl ethers, diammonium salts**  **154518 -**  **40 -**  **8 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono(C10**  **- rich C9**  **- 11**  **- isoalkyl) ethers, phosphates, potassium salts**  **155240 -**  **11 -**  **2 Poly(oxy**  **- 1,**  **2 -**  **ethanediyl), .alpha. -**  **hydro -**  **.omega. -**  **hydroxy -**  **, mono -**  **C12 -**  **18 -**  **alkyl ethers, phosphates 160498**  **- 49**  **- 7**  **Poly(oxy -**  **1,2 -**  **ethanediyl), .alpha. -**  **hydro -**  **.omega. -**  **hydroxy -**  **, mono -**  **C13 -**  **15 -**  **alkyl ethers, phosphates, ammonium salts 160611**  **- 24**  **- 5**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, monotallow alkyl ethers, phosphates, sodium salts**  **171543 -**  **66 -**  **1 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- (hexyloxy)**  **- ,**  **NH4 salt**  **210493 -**  **60 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mixed mono**  **- C16**  **- 2**  **0 -**  **isoalkyl & monotallow alkyl ethers, phosphates, Na salts**  **246159 -**  **55 -**  **7 Poly(oxy**  **- 1,2**  **- ethanediyl), .alpha.**  **- hydro**  **- .omega.**  **- hydroxy** **- , mono**  **- C12**  **- 16**  **- alkyl ethers, phosphates**  **251298 -**  **11 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C16**  **- 18**  **- alkyl ethers,**  **phosphates, sodium salts CASRN**  **AAAPD Chemical Name**

**261627 -**  **68 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C11**  **- 14**  **- isoalkyl ethers,**  **C13 -**  **rich, phosphates, potassium salts 26982**  **- 05**  **- 8**  **Poly(oxy -**  **1,2 -**  **ethaned iyl), a,a'**  **- phosphinicobis[w** **- (dodecyloxy)**  **- 31800**  **- 89**  **- 2**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a' -**  **phosphinicobis[w -**  **(octyloxy) -**  **39341 -**  **09 -**  **8 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- (decyloxy)**  **- 39341**  **- 65**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, 2 -**  **ethylhexyl phosphate 39464**  **- 69**  **- 2**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **(9Z) -**  **9 -**  **octadecen -**  **1 -**  **yl -** **w -**  **hydroxy -**  **, phosphate 422563**  **- 19**  **- 7**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **(2 -**  **ethylhexyl) -** **w -**  **hydroxy -**  **, phosphate, ammonium salt**  **50668 -**  **50 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- (dodecyloxy)**  **- , potassium**  **salt (1:1) 51884**  **- 64**  **- 1**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a' -**  **phosphinicobis[w -**  **(hexyloxy) -**  **57486 -**  **09 -**  **6 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- 9**  **- octadecenyl** **- w**  **- hydroxy** **- , (Z)**  **- , phosphate,**  **sodium salt 59112**  **- 71**  **- 9**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **(9Z) -**  **9 -**  **octadecen -**  **1 -**  **yl -** **w -**  **hydroxy -**  **, phosphate, potassium salt**  **62362 -**  **49 -**  **6 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- octadecyl** **- w**  **- hydroxy** **- , phosphate**  **63747 -**  **86 -**  **4 Oxirane, 2**  **- methyl** **- , polymer with oxirane, monododecyl ether, phosphate**  **63887 -**  **55 -**  **8 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- (decyloxy)**  **- , potassium salt**  **(1:1) 66272**  **- 25**  **- 1**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **isododecyl -** **w -**  **hydroxy -**  **, phosphate 67786**  **- 06**  **- 5**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **[(2 -**  **ethylhexyl)oxy] -**  **, potassium salt (1:2)**  **67989 -**  **06 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hexyl** **- w**  **- hydroxy** **- , phosphate**  **68071 -** **37 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C12**  **- 15**  **- alkyl ethers,**  **phosphate s, potassium salts**  **68130 -**  **44 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C12**  **- 13**  **- alkyl ethers,**  **phosphates, potassium salts 68130**  **- 45**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C12 -**  **13 -**  **alkyl ethers, phosphates**  **68130 -**  **46 -**  **1 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C12**  **- 13**  **- alkyl ethers,**  **phosphates, magnesium salts 68186**  **- 29**  **- 8**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **tridecyl -** **w -**  **hydroxy -**  **, phosphate, sodium salt 68186**  **- 34**  **- 5**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **[(9Z) -**  **1 -**  **oxo -**  **9 -**  **octadecen -**  **1 -** **yl] -** **w -**  **hydroxy -**  **, phosphate, sodium salt**  **68238 -**  **84 -**  **6 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- (2**  **- ethylhexyl)**  **- w**  **- hydroxy** **- , phosphate, potassium**  **salt 68311**  **- 04**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **(tridecyloxy) -**  **, potassium salt (1:2) 68389**  **- 72**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **(sec -**  **pentadecyl) -** **w -**  **hydroxy -**  **, phosphate 68413**  **- 78**  **- 5**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a' -**  **phosphinicobis[w -**  **[(1 -**  **methyltetradecyl)oxy] -**  **68425 -**  **75 -**  **2 Ethanol, 2**  **- amino**  **- , polymer with a**  **- tridecyl** **- w**  **- hydroxypoly(oxy** **- 1,2**  **- ethanediyl) phosphate**  **68439 -** **39 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- (2**  **- ethylhexyl)**  **- w**  **- hydroxy** **- , phosphate**  **68511 -**  **15 -**  **9 Oxirane, 2**  **- methyl** **- , polymer with oxirane, monodecyl ether, phosphate,**  **sodium salt CASRN**  **AAAPD Chemical Name**

**68511 -** **36 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C11**  **- 15**  **- alkyl ethers,**  **p hosphates**  **68551 -**  **05 -** **3 Oxirane, 2**  **- methyl** **- , polymer with oxirane, mono**  **- C10**  **- 12**  **- alkyl ethers,**  **phosphates 68585**  **- 15**  **- 9**  **Oxirane, 2 -**  **methyl -**  **, polymer with oxirane, mono -**  **C6 -**  **10 -**  **alkyl ethers, phosphates**  **68585 -**  **16 -**  **0 Oxirane, 2**  **- methyl** **- , polymer with oxirane, mono**  **- C6**  **- 10**  **- alkyl ethers,**  **phosphates, potassium salts 68585**  **- 17**  **- 1**  **Oxirane, 2 -**  **methyl -**  **, polymer with oxirane, mono -**  **C6 -**  **10 -**  **alkyl ethers, phosphates, sodium salts**  **68585 -** **39 -**  **7 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C8**  **- 10**  **- alkyl ethers,**  **phosphates, sodium salts 68603**  **- 24**  **- 7**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, monococo alkyl ethers, phosphates, ammonium salts**  **68607 -**  **14 -**  **7 Polyphosphoric acids, esters with polyethylene glycol mono**  **- C11**  **- 15**  **- sec**  **- alkyl**  **ethers 68610**  **- 64**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C16 -**  **22 -**  **alkyl ethers, phosphates, sodium salts**  **68649 -** **30 -**  **9 Oxirane, 2**  **- methyl** **- , polymer with oxirane, mono**  **- C12**  **- 18**  **- alkyl ethers,**  **phosphates 68650**  **- 84**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C11 -**  **15 -**  **alkyl ethers, phosphates, potassium salts**  **68855 -**  **46 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C11**  **- 15**  **- sec**  **- alkyl**  **ethers, phosphates, sodium salts 68856**  **- 03**  **- 1**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hy dro**  **- w**  **- hydroxy** **- , mono**  **- C10**  **- 15**  **- sec**  **- alkyl**  **ethers, phosphates 68890**  **- 90**  **- 4**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C11 -**  **15 -**  **branched alkyl ethers, phosphates, potassium salts**  **68890 -**  **91 -**  **5 Oxirane, 2**  **- methyl** **- , polymer with oxirane, mono**  **- C10**  **- 12**  **- alkyl**  **ethers, phosphates, potassium salts**  **68891 -**  **12 -** **3 Oxirane, 2**  **- methyl** **- , polymer with oxirane, mono**  **- C10**  **- 16**  **- alkyl ethers,**  **phosphates, sodium salts 68891**  **- 26**  **- 9**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a' -**  **phosphinicobis[w -**  **(tridecyloxy) -**  **, branched 68909**  **- 65**  **- 9**  **Poly(oxy -**  **1,2 -**  **eth anediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C10**  **- 16**  **- alkyl ethers,**  **phosphates 68909**  **- 67**  **- 1**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono(C8 -**  **18 and C18 -**  **unsatd. alkyl) ethers, phosphates**  **68909 -**  **69 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C11**  **- 13**  **- branched**  **alkyl ethers, phosphates**  **68921 -**  **24 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C6**  **- 12**  **- alkyl ethers,**  **phosphate 68921**  **- 60**  **- 8**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C11 -**  **15 -**  **sec -**  **alkyl ethers, phosphates**  **68954 -**  **87 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl),**  **a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C10 -**  **16 -**  **alkyl ethers, phosphates, potassium salts**  **68954 -**  **88 -**  **1 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C12**  **- 20**  **- alkyl ethers,**  **phosphates, sodium salts CASRN**  **AAAPD Chemical Name**

**68954 -**  **92 -**  **7 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , mono**  **- C11**  **- 13**  **- br**  **anched alkyl ethers, phosphates, potassium salts**  **68987 -** **35 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- eicosyl** **- w**  **- hydroxy** **- , phosphate**  **69029 -**  **43 -**  **2 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- tridecyl**  **- w**  **- hydroxy** **- , phosphate, ammonium salt**  **69980 -**  **69 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- octadecyl** **- w**  **- hydroxy** **- , phosphate, sodium salt**  **70247 -**  **99 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl), .alpha.**  **- hydro**  **- .omega.**  **- hydroxy** **- , mono**  **- C4**  **- 18**  **- alkyl**  **ethers, phosphates, potassium salts 70248**  **- 14**  **- 5**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C6 -**  **10 -**  **alkyl ethers, phosphates**  **70903 -**  **63 -**  **8 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hexadecyl** **- w**  **- hydroxy** **- , phosphate, sodium salt**  **71965 -**  **23 -**  **6 Oxirane, 2**  **- methyl** **- , polymer with oxirane, mono(dihydrogen phosphate),**  **tridecyl ether 71965**  **- 24**  **- 7**  **Oxirane, 2 -**  **methyl -**  **, polymer with oxirane, mono(dihydrogen phosphate),**  **tridecyl ether, dipotassium salt 72480**  **- 27**  **- 4**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C9 -**  **16 -**  **alkyl ethers, phosphates**  **72623 -**  **67 -**  **7 Oxirane, 2**  **- methyl** **- , polymer with oxirane, mono(dihydrogen phosphate), 2**  **- ethylhexyl ether**  **72623 -**  **68 -**  **8 Oxir**  **ane, 2 -**  **methyl -**  **, polymer with oxirane, hydrogen phosphate (2:1), bis(2 -**  **ethylhexyl) ether 72828**  **- 56**  **- 9**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a' -**  **phosphinicobis[w -**  **hydroxy -**  **, di -**  **C12 -**  **14 -**  **alkyl ethers, potassium salts**  **72828 -**  **57 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- phosphono**  **- w**  **- hydrox** **y -**  **, C12 -**  **14 -**  **alkyl ethers, dipotassium salts**  **73018 -** **34 -**  **5 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- octyl** **- w**  **- hydroxy** **- , phosphate, potassium salt**  **73050 -**  **08 -**  **5 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- hydroxy** **- , di** **- C13**  **- 15**  **- alkyl**  **ethers, sodium salts 73050**  **- 09**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **hydroxy -**  **, C13 -**  **15 -**  **alkyl ethers, disodium salts**  **73361 -**  **29 -**  **2 Oxirane, methyl** **- , polymer with oxirane, monohexadecyl ether, phosphate**  **73378 -**  **71 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- hydroxy** **- , di**  **- C9**  **- 11**  **- alkyl**  **ethers, sodium salts 73378**  **- 72**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **hydroxy -**  **, C9 -**  **11 -**  **alkyl ethers, disodium salts**  **73559 -**  **42 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- hydroxy** **- , di** **- C10**  **- 20**  **- alkyl**  **ethers 73559**  **- 43**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a,a'**  **- phosphinicobis[w** **- hydroxy** **- , di** **- C10**  **- 20**  **- alkyl**  **ethers, potassium salts 73559**  **- 44**  **- 1**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **phosphono -** **w -**  **hydroxy -**  **, C10 -**  **20 -**  **alkyl ethers, dipotassium salts**  **73559 -**  **45 -**  **2 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- phosphono**  **- w**  **- hydroxy** **- , C10**  **- 20**  **- alkyl ethers**  **74499 -**  **76 -**  **6 Poly(oxy**  **- 1,2**  **- ethanediyl), a,a'**  **- phosphinicobis[w** **- (tridecyloxy)**  **- , potassium**  **salt (1:1) 76930**  **- 25**  **- 1**  **Phosphoric acid, mono -**  **and di -**  **C12 -**  **18 alkyl ester, sodium salt, ethoxylated 78330**  **- 22**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono**  **- C11**  **- 14**  **- isoalkyl ethers,**  **C13 -**  **rich, phosphates, ethoxylated CASRN**  **AAAPD Chemical Name**

**9004 -**  **80 -**  **2 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- phosphono**  **- w**  **- (decyloxy)**  **- 91254**  **- 26**  **- 1**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono(C16 and C18 -**  **unsatd. alkyl) ethers, phosphates**  **93925 -**  **54 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- hydro**  **- w**  **- hydroxy** **- , monococo alkyl ethers,**  **phosphates, sodium salts 96416**  **- 89**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **hydro -** **w -**  **hydroxy -**  **, mono -**  **C11 -**  **15 -**  **sec -**  **alkyl ethers, phosphates, potassium salts** 

**AAASD Surfactants: 40CFR 180.910 and 180**  **.930: α -** **Alkyl(C 6**  **- C**  **15 )**  **- ω**  **- hydroxypoly(oxyethylene) sulfate, and its**  **ammonium, calcium, magnesium, potassium, sodium, and zinc salts, poly(oxyethylene) content averages 2**  **- 4 moles;**  **used as surfactants not to exceed 30% of pesticide formulation. CASRN**  **AAASD Chemical Name**  **106597 -**  **03 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C13**  **- 15**  **- branched alkyl ethers,**  **sodium salts 110392**  **- 50**  **- 2**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C12 -**  **13 -**  **alkyl ethers, sodium salts**  **125301 -**  **88 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl),**  **a -**  **sulfo -** **w -**  **hydroxy -**  **, C12 -**  **14 -**  **alkyl ethers, ammonium salts**  **125301 -**  **89 -**  **5 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C12**  **- 15**  **- alkyl ethers,**  **ammonium salts 125301**  **- 92**  **- 0**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C12 -**  **15 -**  **alkyl ethers, sodium salts**  **125736 -**  **54 -**  **1 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C12**  **- 14**  **- sec**  **- alkyl ethers,**  **sodium salts 157707**  **- 85**  **- 2**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C6 -**  **12 -**  **alkyl ethers, sodium salts**  **160104 -**  **51 -**  **8 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C12**  **- 14**  **- alkyl ethers,**  **magnesium salts 160901**  **- 27**  **- 9**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C9 -**  **11 -**  **branched and linear alkyl ethers, ammonium salts**  **160901 -**  **28 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C9**  **- 11**  **- branched and linear**  **alkyl ethers, sodium salts 160901**  **- 29**  **- 1**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C11 -**  **14 -**  **branched and linear alkyl ethers, sodium salts**  **160901 -** **30 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C9**  **- 15**  **- alkyl ethers, sodium**  **salts 161025**  **- 28**  **- 1**  **Alcohols, C6 -**  **12, ethoxylated, sulfates, sodium salts**  **161074 -**  **79 -**  **9 Alcohols, C12**  **- 13, branched and linear, ethoxylated, sulfates, sodium salts**  **162063 -**  **19 -**  **6 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C13**  **- 15**  **- branched and linear**  **alkyl ethers, sodium salts 27140**  **- 00**  **- 7**  **Ethanol, 2 -**  **[2 -**  **(dodecyloxy)ethoxy] -**  **, 1**  **- (hydrogen sulfate), ammonium salt**  **27731 -**  **61 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- (tetradecyloxy)**  **- , ammonium salt (1:1)** **27731 -**  **62 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- (tetradecyloxy)**  **- sodium salt (1:1)** 

**34431 -**  **25 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl),**  **a -**  **sulfo -** **w -**  **(octyloxy) -**  **, sodium salt (1:1) 35015**  **- 74**  **- 8**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(pentadecyloxy) -**  **, sodium salt (1:1) 52286**  **- 18**  **- 7**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(octyloxy) -**  **, ammonium salt (1:1) 52286**  **- 19**  **- 8**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(decyloxy) -**  **, ammonium salt 54116**  **- 08**  **- 4**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(tridecyloxy) -**  **, sodium salt 61702**  **- 79**  **- 2**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(tridecyloxy) -**  **, ammonium salt (1:1) 63428**  **- 86**  **- 4**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(hexyloxy) -**  **, ammonium salt (1:1)**  **63428 -**  **87 -**  **5 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- (decyloxy)**  **- , sodium salt (1:1)**  **65086 -**  **57 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- (decyloxy)**  **- 65086**  **- 79**  **- 5**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(tetradecyloxy) -**  **67674 -**  **66 -**  **2 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- (pentadecyloxy)**  **- 67845**  **- 82**  **- 3**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(octyloxy) -**  **67845 -**  **83 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- (pentadecyloxy)**  **- , ammonium salt**  **68037 -**  **05 -**  **8 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C6**  **- 10**  **- alkyl ethers, ammonium**  **salts 68037**  **- 06**  **- 9**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C6 -**  **10 -**  **alkyl ethers 68171**  **- 41**  **- 5**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **(hexyloxy) -**  **68610 -**  **66 -**  **2 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C10**  **- 12**  **- alkyl ethers, sodium**  **salts 68649**  **- 53**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C12 -**  **13 -**  **alkyl ethers, ammonium salts**  **68890 -**  **88 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C10**  **- 12**  **- alkyl ethers,**  **ammonium salts 68891**  **- 29**  **- 2**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C8 -**  **10 -**  **alkyl ethers, ammonium salts**  **68891 -** **30 -**  **5 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C11**  **- 15**  **- branched alkyl ethers,**  **ammonium salts 69011**  **- 37**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C8 -**  **14 -**  **alkyl ethers, ammonium salts**  **75422 -**  **21 -**  **8 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydrox** **y -**  **, C6 -**  **12 -**  **alkyl ethers, ammonium salts**  **78330 -**  **17 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- (hexyloxy)**  **- , branched, sodium salt**  **78330 -**  **16 -**  **2 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- (hexyloxy)**  **- , branched, ammonium salt**  **78330 -**  **25 -** **3 Poly(oxy**  **- 1,2**  **- ethanediyl),**  **a -**  **sulfo -** **w -**  **hydroxy -**  **, C7 -**  **9 -**  **isoalkyl ethers, C8 -**  **rich, ammonium salts**  **78330 -**  **26 -**  **4 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C9**  **- 11**  **- isoalkyl ethers, C10**  **- rich, ammonium salts**  **78330 -**  **27 -**  **5 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C11**  **- 14**  **- isoalkyl ethers, C1**  **3 -**  **rich, ammonium salts 78330**  **- 28**  **- 6**  **Poly(oxy -**  **1,2 -**  **ethanediyl), a -**  **sulfo -** **w -**  **hydroxy -**  **, C7 -**  **9 -**  **isoalkyl ethers, C8 -**  **rich, sodium salts**  **78330 -**  **29 -**  **7 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C9**  **- 11**  **- isoalkyl ethers, C10**  **- rich, sodium salts**  **78330 -** **30 -**  **0 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C11**  **- 14**  **- isoalkyl ethers, C13**  **- rich, sodium salts** 

**9021 -**  **91 -**  **4 Poly[oxy(methyl** **- 1,2**  **- ethanediyl)], a**  **- sulfo**  **- w**  **- (octyloxy)**  **- , sodium salt (1:1)**  **96130 -**  **61 -**  **9 Poly(oxy**  **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C9**  **- 11**  **- alkyl**  **ethers, sodium salts**  in or on all raw agricultural commodities. **[Prior to the submission of this petition to add missing CASRNs, Petition PP 9E7533 (Document ID EPA** **- HQ**  **- OPP**  **- 2009**  **- 0131) was**  **submitted to the Agency and these CASRNs were missing from the pet ition. JITF CST**  **2 is**  **relying on the information submitted in 9E7533 to support this petition which includes the**  **exact same chemistr ies**  **. JITF CST 2**  **does not expect the addition of these CASRNs to result in additional exposure or risk.**  **]** EPA has determined that the petition contains data or information regarding the elements set forth in section 408 (d)(2) of FFDCA; however, EPA has not fully evaluated the sufficiency of the submitted data at this time or whether the data supports granting of the petition. Additional data may be needed before EPA rules on the petition. A. Residue Chemistry 1. Plant metabolism. **[Not Applicable]** 2. Analytical method. **[Not Applicable]** 3. Magnitude of residues. **[ There is no specific crop residue information available for**  **AAAPD and AAASD and this information is typically not available nor required for the establishment of a tolerance exemption for inert ingredients.]**  B. Toxicological Profile 

### 1. Acute toxicity. [ **AAAPD and AAASD are likely skin/eye irritants in their**  **undiluted forms, but not acutely toxic. The reported oral LD 50**  **values were higher than 1,600 mg/kg for the alkyl ether phosphates C**  **13 EO**  **3,6,12 P, CASRN 9046**  **- 01**  **- 9 and alkyl ether**  **sulfates NaC 12**  **EO 3**  **S, CASR N 9004**  **- 82**  **- 4 (Category III). No effects were found at any of the**  **concentrations tested dermally.** 

### ] 2. Genotoxicity. **[ NaC**  **12 -**  **15 EO**  **2 -** **3 S compounds were not mutagenic in bacterial or**  **ma mmalian**  **in vitro cell systems or**  **in vivo (HERA 2003).**  **Neither IARC, NTP nor OSHA**  **listed as a carcinogen.]** 3. Reproductive and developmental toxicity. **[One representative compound for the group of chemicals requested in**  **9E7533 (and 2E8092) is CASRN**  **68891 -** **38 -** **3 Poly(oxy** **- 1,2**  **- ethanediyl), a**  **- sulfo**  **- w**  **- hydroxy** **- , C12**  **- 14**  **- alkyl ethers, so**  **dium salts .**  **The studies with the sulfate derivatives**  **(AAASD) showed little to no toxicity in the dams or the pups, with the**  **NOEL in a developmental toxicity study in rats with CASRN 68891 -** **38 -** **3 at the limit dose of 1000 mg/kg/day, and a reproductive NOAEL**  **of 0.3% in drinking water, equivalent to 300 mg/kg/day, the highest dose tested, in a two**  **- generation reproduction study with**  **CASRN 68891 -** **38 -** **3). CASRN 68891**  **- 38**  **- 3 was evaluated for effects on the reproduction and prenatal/postnatal**  **development of the rat when administered orally via the drinking water through two**  **successive generations. No reproductive or developmental effects were observed at any** **dose, even where corresponding parental toxicity was observed. The NOAEL for**

**reproductive effects was 0.3% i n drinking water, equivalent to 300 mg/kg/day, the highest**  **dose tested. In studies with the phosphate derivatives (AAAPD), the reproductive/developmental NOEL**  **for the OECD 422 study with CASRN 68130**  **- 47**  **- 2 was 800 mg/kg/day, the highest dose**  **tested, and fo r CASRN 78330**  **- 24**  **- 2 the NOEL was 200 mg/kg/day.**  4. Subchronic toxicity. **[Based on the Federal Register Notice (August 9, 2006, Volume 71, Number 153, pages 45415**  **- 45424), the Agency stated that the preferred test for**  **repeat -**  **dose toxicity is the “Combined Repeated Dose Toxicity Study with the**  **Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 422).” AAAPD (CASRN 68130**  **- 47**  **- 2 and CASRN 78330**  **- 24**  **- 2) have been tested in repeat dose**  **studies (OECD 422 Combined Repeated Dose Toxicity Study with a**  **Reproduction/Developmental Toxicity Screening Test). The paternal and maternal NOAEL for CASRN 68130**  **- 47**  **- 2 was 200 mg/kg/day. The paternal and maternal no**  **** **observable -**  **effect -**  **level (NOEL) for CASRN 78330 -**  **24 -**  **2 was 200 mg/kg/day. The NOAEL of 200 mg/kg/da** **y was selected as the toxicology endpoint for the chronic risk assessment for the phosphate derivatives (AAAPD).**  **Subchronic data have been found in the public domain for the AAASD. Subchronic 21**  **- day repeat dose dietary studies showed low toxicity of com** **pounds with carbon lengths of C**  **12 -**  **15 , C**  **12 -**  **14 and C**  **13 -**  **15 with sodium or ammonium alkyl ethoxylates with POE n=3. One**  **study indicated that C 16**  **- 18**  **POE n=18 had comparable low toxicity. No**  **- observed**  **- adverse** **** **effect levels (NOAELs) range from 120 to 468 mg/kg/d ay, similar to a NOAEL from a 90**  **- day**  **rat gavage study with NaC 12**  **- 14**  **POE n=2(CASRN 68891 -** **38 -** **3), which was reported to be 225 mg/kg/day. In addition, another**  **90 -**  **day repeat dose dietary study with NaC 12**  **- 15**  **POE n=3(CASRN 68424**  **- 50**  **- 0) resulted in low toxicity,**  **with a NOAEL of greater than approximately 50 mg/kg/day (calculated based on dose of 1000 ppm in diet). Effects were**  **usually related to hepatic hypertrophy, increased liver weight, and related increases in hematological endpoints related to liver enzyme i**  **nduction. Henkel KgaA (1994a) evaluated CASRN 68891**  **- 38**  **- 3 for systemic toxicity in Wistar**  **(Hsd/Win:WU) rats by gavage at doses of 0, 25, 75, and 225 mg/kg/day for 90 -**  **days. No treatment related symptoms including changes in mean food consumption or water i**  **ntake, total body weight gain, hematological examinations, clinical chemistry, absolute and**  **relative organ weights and macroscopical examinations were observed in any group. According to systemic, behavioral, and clinical abnormalities the NOAEL of 225 m**  **g/kg/day for sodium lauryl ether sulfate was determined.**  **CASRN 68891 -** **38 -** **3 was evaluated for effects on the reproduction and prenatal/postnatal development of the rat when administered orally via the drinking water through two**  **successive generations. Based on this study an overall**  **no -**  **observed -**  **adverse -**  **effect level (NOAEL) for systemic effects was 0.1%, which was 86.6 mg/kg/day for the F0 generation,**  **and 149.5 mg/kg/day for the F1 generation. The NOAEL of 86.6 mg/kg/day was selected as the toxicology endpoint**  **for the chronic risk assessment for the sulfate derivatives (AAASD).**  **]**5. Chronic toxicity **[Based on the Federal Register Notice (August 9, 2006, Volume**

**71, Number 153, pages 45415 -**  **45424), the Agency stated that the preferred test for repeat****** **dose toxicity is the “Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity**  **Screening Test (OECD Test Guideline 422).” Chronic dietary studies conducted with rats on AAASDs showed no incidence of cancer**  **and no effects at the concentrations tested (lowest dose tested was ca 75 mg/kg/day).]** 6. Animal metabolism. **[ The mammalia**  **n metabolic pathway for AAASD type surfactants has been published. The mammalian metabolic pathway for AAASD type**  **surfactants has been published (HERA, 2003). For compounds of comparable C16 carbon chain, the metabolites of the lower molecular weight etho**  **xylated (POE n=3) AAASD surfactants are readily absorbed and excreted primarily in the urine whereas for the C16**  **AAASD surfactants with increased ethoxylation (POE n=9) are poorly absorbed and excreted primarily in the feces (McDermott et al., 1975). The**  **re was also no evidence of hydrolysis of the sulfate group from C**  **16 POE n= 3 and C**  **16 POE n=9 or of metabolism of**  **the ethoxylate portion of the molecule. With C 11**  **POE n=3 and C 12**  **POE n=3 metabolic studies in rats confirmed that the alkyl chain is extensively metabolized by beta**  **- or omega**  **** **oxidation leaving the ethoxysulfate, which is excreted directly (Taylor et al., (1978) By analogy to what would generally be expected in the met**  **abolism for phosphate esters, the AAAPD surfactants may initially undergo metabolism to generate the**  **corresponding AAA and POE (or POE/POP) phosphate glycol. By analogy to the reported metabolism for the CST1 Alkyl Alkoxylate Alcohol (AAA) surfactants, th**  **e dephosphoralyted metabolite should be hydrolyzed to the POE (or POE/POP)**  **polyalkoxylate glycols and linear branched saturated and unsaturated alkyl alcohol metabolites. The resultant alkyl alcohol metabolites would be oxidized in fatty acid**  **oxidation pa thways. The polyalkoxylate glycols may either be conjugated and**  **excreted unchanged or hydrolyzed/oxidized to various degraded metabolites before being conjugated and excreted.]**  7. Metabolite toxicology

. **[No metabolites of toxicological concern are exp ected based**  **on the proposed animal metabolic pathway.]** 

### 8. Endocrine disruption

. [ **The AAAPD and AAASD surfactants do not belong to a class of chemicals known or suspected of having adverse effects on the estrogen receptor or**  **endocrine system. AAAPD and A AASD have been evaluated in acute, subchronic,**  **developmental and reproductive studies capable of detecting effects on endocrine mediated events.**  **The results of these studies did not give any indication of a treatment -**  **related effect on the estrogen receptor**  **or endocrine system.]** C. Aggregate Exposure 1. Dietary exposure. **[ The dietary (food plus drinking water) exposures for AAAPD**  **and AAASD surfactants are expressed as a percentage of the proposed chronic population adjusted dose (cPAD) for the general US p**  **opulation and children 1 -**  **2 years old, the subpopulation with the highest potential exposures.** **Based on I -** **DEEM screening level calculations, the chronic dietary exposures for the**

**AAAPD are estimated to be 6% of the cPAD for the general U.S. population an d 21% of**  **the cPAD for children 1 -**  **2 years old. Based on I**  **- DEEM screening level calculations, the chronic dietary exposures for the**  **AAASD are estimated to be 14% of the cPAD for the general U.S. population and 49% of the cPAD for children 1**  **- 2 years old.**  **These data demonstrate that the I -** **DEEM screening level chronic dietary (food and drinking water) exposures for both the**  **AAAPD and AAASD are well below 100% of the**  **cPAD, and are therefore below EPA’s established level of concern for all U.S. subpopulation**  **s. On the basis of the OECD 422 repeat dose toxicity study and comparison of I**  **- DEEM**  **exposures to the proposed cPAD, the JITF CST2 asserts that there is sufficient basis for EPA to grant a tolerance exemption for these additional AAAPD and AAASD surfactant**  **CAS RNs.**  **CHRONIC DIETARY SAFETY ASSESSMENT, % cPAD** 

**Study Chronic** 

**Systemic NOAEL**  **1 mg/kg**  **bw/day cPAD**  **2**

**mg/kg bw/day**  **Percent**

**cPAD Children**  **1 -**  **2 years of age**  **Percent**

**cPAD U.S. Gen**  **Population AAAPD CASRN 68130**  **- 47**  **- 2**  **and CASRN 78330 -**  **24 -**  **2; Repeated Dose Toxicity with**  **Reproduction/ Developmental Toxicity**  **Screening in Rats -**  **(OECD 422)**  **AAASD Sulfate CASRN 68891**  **- 38**  **- 3; systemic**  **toxicity endpoint for repeated dose from the two**  **generation rat reproductive drinking water st**  **udy 200** 

**87 2.0** 

**0.87 21%** 

**49% 6%** 

**14%**

**Note: 1**  **NOAEL**

**– No observed adverse effect level**  **2 cPAD** 

**– Chronic population adjusted dose, defined as: chronic NOAEL / (safety factor**   **FQ PA factor)**  i. Food. **[The available data demonstrate that the I**  **- DEEM screening level chronic**  **dietary (food and drinking water) exposures are well below 100% of the cPAD, and are therefore below EPA’s established level of concern for all U.S. subpopulations.]** ii. Drinking water. **[Drinking water is included in the I**  **- DEEM exposure assessment.** 

**Exposure to AAAPD and AAASD**  **via drinking water is expected to be negligible.]** 2. Non

- dietary exposure

. **[AAAPD and AAASD surfactants are used as inert**  **ingredients in agricultural formulations as well as in non -** **pesticidal uses such as, personal care products**  **household cleaning products and laundry detergents. Given the low estimate**  **of dietary exposure, there is ample room in the overall aggregate MOE for non**  **- dietary**  **uses.]** D. Cumulative Effects **[ Fo**  **r the purpose of the tolerance exemption actions cited herein, the JITF CST2 has assumed that the**  

### AAAPD and AAASD **will not have a common mechanism of toxicity with other surfactan**  **t substances. It is therefore appropriate to consider only the potential risks**  **of the compounds included in CST2 in the exposure assessment.]** E. Safety Determination 1. U.S. population. [ **A dietary exposure assessment using current EPA inert screening**  **level methodology (I -** **DEEM) was conducted. Based on the conservative I -** **DEEM dietary exposure estimates, there is a reasonable certainty that no harm will result to the**  **US population from the aggregate exposure to AAAPD and AAASD**

. **]** 2. Infants and children

. **[ The FFDCA Section 408 requires an additional tenfold**  **ma rgin of safety for the protection of infants and children in case of threshold effects to**  **account for prenatal and postnatal toxicity, and an inadequate toxicity database. Where an adequate and relia**  **ble database is available and there is a lack of evidence for increased susceptibility, the FQPA safety factor may be reduced or removed. An evaluation of**  **susceptibility and uncertainty issues associated with Anionic Alkyl Alkoxylate Derivatives has been**  **performed. Based on the points below, the JITF CST2 recommends that the FQ**  **PA safety factor be reduced from the default 10X to 1X.**

 **A scientifically sound mammalian toxicology database, which includes acute, subchronic, reproductive, and developmental tox**  **icity data, indicates no adverse effects to sensitive populations.**   **The AAAPD and AAASD surfactants do not belong to a class of chemicals known or suspected of having adverse effects on the estrogen receptor or endocrine system. These**  **surfactants have been evaluated in acute, subchronic, developmental and reproductive stu**  **dies capable of detecting effects on endocrine mediated events.**  **The AAASDs have also been evaluated in chronic studies including a two year dietary study (Moore 1983) and a two generation reproduction study with drinking water**  **(Henkel KGaA 1999, MRID 4706**  **09903, 47112401) .**   **OECD 422 testing and other reproduction and developmental studies available in the literature (HERA, 2003) indicates no reproductive and no developmental effects in**  **offspring at levels that are not maternally toxic.**  **There was no evidence of effects on the nervous system in the acute, subchronic or**  **reproduction studies. ]**  F. International Tolerances**[There are no known international tolerances for Alkyl Alcohol Alkoxylate** 

**Phosphate and Sulfate Derivatives** .]