EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR PESTICIDE 

PETITIONS PUBLISHED IN THE FEDERAL REGISTER 

EPA Registration Division contact: [P.V. Shah, 703-308-1846]

INSTRUCTIONS: Please utilize this outline in preparing the pesticide petition. In cases 

where the outline element does not apply, please insert “NA-Remove” and maintain the 

outline. Please do not change the margins, font, or format in your pesticide petition. Simply 

replace the instructions that appear in green, i.e., “[insert company name],” with the 

information specific to your action

[Joint Inerts Task Force, Cluster Support Team 2 (JITF CST2)]

[2E8092]

EPA has received a pesticide petition (2E8092) from [Joint Inerts Task Force, Cluster 

Support Team 2, EPA Company Number 84914], [c/o Huntsman Corp., 8600 Gosling Rd., 

The Woodlands, TX 77381] proposing, pursuant to section 408(d) of the Federal Food, Drug, 

and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part 180.

To amend existing exemptions from the requirement of a tolerance [by adding Chemical 

Abstracts Service Registry Numbers (CASRNs) for post-harvest use on agricultural crops 

under 40 CFR §180.910 and when applied to animals under 40 CFR §180.930 for the 

following two chemistry descriptors that are used as surfactants not to exceed 30% of 

pesticide formulation: Alkyl Alcohol Alkoxylate Phosphate and Sulfate Derivatives 

(AAAPD and AAASD respectively), including:

AAAPD Surfactants:

40 CFR §180.910 and §180.930: α-Alkyl (minimum C6 linear or branched, saturated and or 

unsaturated)-ω-hydroxypolyoxyethylene polymer with or without polyoxypropylene, 

mixture of di- and monohydrogen phosphate esters and the corresponding ammonium, 

calcium, magnesium, monoethanolamine, potassium, sodium, and zinc salts of the 

phosphate esters; minimum oxyethylene content averages 2 moles; minimum oxypropylene 

content is 0 moles; used as surfactants not to exceed 30% of pesticide formulation.

CASRN AAAPD Chemical Name

103170-31-6

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C8-10-alkyl ethers, 

phosphates, potassium salts

103170-32-7

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, monococo alkyl ethers, 

phosphates, potassium salts

106233-09-4 Alcohols, C16-18, ethoxylated, phosphates

106233-10-7

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-20-alkyl ethers, 

phosphates

1072943-56-6

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-14-isoalkyl ethers, 

C13-rich, phosphates, sodium salts

110392-49-9 Alcohols, C9-11, ethoxylated, phosphated, sodium salt 
CASRN AAAPD Chemical Name

111798-26-6 Poly(oxy-1,2-ethanediyl), a-(2-ethylhexyl)-w-hydroxy-, phosphate, Na salt

111905-50-1 Alcohols C16-18, ethoxylated, phosphated, potassium salt

116671-23-9

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C12-14-alkyl 

ethers, sodium salts

117584-36-8

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C12-15-alkyl 

ethers

1187742-89-7 Alcohols C16-18 and C18 unsatured, ethoxylated (2 EO), phosphate salt 

1187743-35-6 Alcohols, C16-18 and C18-unsatd., ethoxylated, phosphate, potassium salt

119415-05-3

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C16-20-alkyl ethers, 

phosphates, sodium salts

121158-61-0

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C12-14-alkyl 

ethers

121158-63-2 Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C12-14-alkyl ethers 

125139-13-1 Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C14-18-alkyl ethers

125301-86-2 Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C6-10-alkyl ethers

125301-87-3

Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C10-14-alkyl ethers, 

potassium salts

126646-03-5

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C10-14-alkyl ethers, 

phosphates, potassium salts 

129870-77-5

Oxirane, methyl-, polymer with oxirane, mono(C13-15-branched and linear 

alkyl) ethers, phosphates

129870-80-0

Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C10-14-alkyl ethers, 

disodium salts

130354-37-9

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-13-alkyl ethers, 

phosphates, sodium salts 

136504-88-6

Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C9-11-alkyl 

ethers, phosphates

143372-50-3

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C13-15-alkyl 

ethers, ammonium salts

143372-51-4

Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C13-15-alkyl ethers, 

diammonium salts

154518-40-8

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono(C10-rich C9-11-

isoalkyl) ethers, phosphates, potassium salts

155240-11-2

Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C12-18-

alkyl ethers, phosphates

160498-49-7

Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C13-15-

alkyl ethers, phosphates, ammonium salts

160611-24-5

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, monotallow alkyl ethers, 

phosphates, sodium salts 

171543-66-1 Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(hexyloxy)-, NH4 salt 

210493-60-0

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mixed mono-C16-20-isoalkyl 

& monotallow alkyl ethers, phosphates, Na salts 

246159-55-7

Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C12-16-

alkyl ethers, phosphates

251298-11-0

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C16-18-alkyl ethers, 

phosphates, sodium salts 
CASRN AAAPD Chemical Name

261627-68-3

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-14-isoalkyl ethers, 

C13-rich, phosphates, potassium salts

26982-05-8 Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(dodecyloxy)-

31800-89-2 Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(octyloxy)-

39341-09-8 Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(decyloxy)-

39341-65-6 Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, 2-ethylhexyl phosphate 

39464-69-2 Poly(oxy-1,2-ethanediyl), a-(9Z)-9-octadecen-1-yl-w-hydroxy-, phosphate 

422563-19-7

Poly(oxy-1,2-ethanediyl), a-(2-ethylhexyl)-w-hydroxy-, phosphate, 

ammonium salt

50668-50-3

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(dodecyloxy)-, potassium 

salt (1:1)

51884-64-1 Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(hexyloxy)-

57486-09-6

Poly(oxy-1,2-ethanediyl), a-9-octadecenyl-w-hydroxy-, (Z)-, phosphate, 

sodium salt 

59112-71-9

Poly(oxy-1,2-ethanediyl), a-(9Z)-9-octadecen-1-yl-w-hydroxy-, phosphate, 

potassium salt

62362-49-6 Poly(oxy-1,2-ethanediyl), a-octadecyl-w-hydroxy-, phosphate 

63747-86-4 Oxirane, 2-methyl-, polymer with oxirane, monododecyl ether, phosphate 

63887-55-8

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(decyloxy)-, potassium salt 

(1:1)

66272-25-1 Poly(oxy-1,2-ethanediyl), a-isododecyl-w-hydroxy-, phosphate

67786-06-5

Poly(oxy-1,2-ethanediyl), a-phosphono-w-[(2-ethylhexyl)oxy]-, potassium salt 

(1:2)

67989-06-4 Poly(oxy-1,2-ethanediyl), a-hexyl-w-hydroxy-, phosphate 

68071-37-4

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-15-alkyl ethers, 

phosphates, potassium salts

68130-44-9

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-13-alkyl ethers, 

phosphates, potassium salts

68130-45-0

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-13-alkyl ethers, 

phosphates

68130-46-1

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-13-alkyl ethers, 

phosphates, magnesium salts 

68186-29-8 Poly(oxy-1,2-ethanediyl), a-tridecyl-w-hydroxy-, phosphate, sodium salt

68186-34-5

Poly(oxy-1,2-ethanediyl), a-[(9Z)-1-oxo-9-octadecen-1-yl]-w-hydroxy-, 

phosphate, sodium salt 

68238-84-6

Poly(oxy-1,2-ethanediyl), a-(2-ethylhexyl)-w-hydroxy-, phosphate, potassium 

salt

68311-04-6 Poly(oxy-1,2-ethanediyl), a-phosphono-w-(tridecyloxy)-, potassium salt (1:2)

68389-72-0 Poly(oxy-1,2-ethanediyl), a-(sec-pentadecyl)-w-hydroxy-, phosphate 

68413-78-5 Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-[(1-methyltetradecyl)oxy]-

68425-75-2

Ethanol, 2-amino-, polymer with a-tridecyl-w-hydroxypoly(oxy-1,2-

ethanediyl) phosphate

68439-39-4 Poly(oxy-1,2-ethanediyl), a-(2-ethylhexyl)-w-hydroxy-, phosphate

68511-15-9

Oxirane, 2-methyl-, polymer with oxirane, monodecyl ether, phosphate, 

sodium salt 
CASRN AAAPD Chemical Name

68511-36-4

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-alkyl ethers, 

phosphates

68551-05-3

Oxirane, 2-methyl-, polymer with oxirane, mono-C10-12-alkyl ethers, 

phosphates

68585-15-9

Oxirane, 2-methyl-, polymer with oxirane, mono-C6-10-alkyl ethers, 

phosphates

68585-16-0

Oxirane, 2-methyl-, polymer with oxirane, mono-C6-10-alkyl ethers, 

phosphates, potassium salts 

68585-17-1

Oxirane, 2-methyl-, polymer with oxirane, mono-C6-10-alkyl ethers, 

phosphates, sodium salts

68585-39-7

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C8-10-alkyl ethers, 

phosphates, sodium salts

68603-24-7

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, monococo alkyl ethers, 

phosphates, ammonium salts 

68607-14-7

Polyphosphoric acids, esters with polyethylene glycol mono-C11-15-sec-alkyl 

ethers 

68610-64-0

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C16-22-alkyl ethers, 

phosphates, sodium salts

68649-30-9

Oxirane, 2-methyl-, polymer with oxirane, mono-C12-18-alkyl ethers, 

phosphates 

68650-84-0

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-alkyl ethers, 

phosphates, potassium salts 

68855-46-9

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-sec-alkyl 

ethers, phosphates, sodium salts

68856-03-1

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C10-15-sec-alkyl 

ethers, phosphates 

68890-90-4

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-branched alkyl 

ethers, phosphates, potassium salts 

68890-91-5

Oxirane, 2-methyl-, polymer with oxirane, mono-C10-12-alkyl ethers, 

phosphates, potassium salts

68891-12-3

Oxirane, 2-methyl-, polymer with oxirane, mono-C10-16-alkyl ethers, 

phosphates, sodium salts 

68891-26-9 Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(tridecyloxy)-, branched 

68909-65-9

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C10-16-alkyl ethers, 

phosphates

68909-67-1

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono(C8-18 and C18-unsatd. 

alkyl) ethers, phosphates

68909-69-3

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-13-branched alkyl 

ethers, phosphates

68921-24-4

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C6-12-alkyl ethers, 

phosphate

68921-60-8

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-sec-alkyl 

ethers, phosphates 

68954-87-0

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C10-16-alkyl ethers, 

phosphates, potassium salts

68954-88-1

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-20-alkyl ethers, 

phosphates, sodium salts
CASRN AAAPD Chemical Name

68954-92-7

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-13-branched alkyl 

ethers, phosphates, potassium salts

68987-35-9 Poly(oxy-1,2-ethanediyl), a-eicosyl-w-hydroxy-, phosphate 

69029-43-2 Poly(oxy-1,2-ethanediyl), a-tridecyl-w-hydroxy-, phosphate, ammonium salt

69980-69-4 Poly(oxy-1,2-ethanediyl), a-octadecyl-w-hydroxy-, phosphate, sodium salt 

70247-99-3

Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C4-18-alkyl 

ethers, phosphates, potassium salts

70248-14-5

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C6-10-alkyl ethers, 

phosphates 

70903-63-8 Poly(oxy-1,2-ethanediyl), a-hexadecyl-w-hydroxy-, phosphate, sodium salt

71965-23-6

Oxirane, 2-methyl-, polymer with oxirane, mono(dihydrogen phosphate), 

tridecyl ether

71965-24-7

Oxirane, 2-methyl-, polymer with oxirane, mono(dihydrogen phosphate), 

tridecyl ether, dipotassium salt

72480-27-4

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C9-16-alkyl ethers, 

phosphates

72623-67-7

Oxirane, 2-methyl-, polymer with oxirane, mono(dihydrogen phosphate), 2-

ethylhexyl ether

72623-68-8

Oxirane, 2-methyl-, polymer with oxirane, hydrogen phosphate (2:1), bis(2-

ethylhexyl) ether

72828-56-9

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C12-14-alkyl 

ethers, potassium salts

72828-57-0

Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C12-14-alkyl ethers, 

dipotassium salts

73018-34-5 Poly(oxy-1,2-ethanediyl), a-octyl-w-hydroxy-, phosphate, potassium salt

73050-08-5

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C13-15-alkyl 

ethers, sodium salts

73050-09-6

Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C13-15-alkyl ethers, 

disodium salts 

73361-29-2 Oxirane, methyl-, polymer with oxirane, monohexadecyl ether, phosphate 

73378-71-9

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C9-11-alkyl 

ethers, sodium salts

73378-72-0

Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C9-11-alkyl ethers, 

disodium salts

73559-42-9

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C10-20-alkyl 

ethers

73559-43-0

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C10-20-alkyl 

ethers, potassium salts

73559-44-1

Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C10-20-alkyl ethers, 

dipotassium salts 

73559-45-2 Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C10-20-alkyl ethers

74499-76-6

Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(tridecyloxy)-, potassium 

salt (1:1)

76930-25-1 Phosphoric acid, mono- and di-C12-18 alkyl ester, sodium salt, ethoxylated

78330-22-0

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-14-isoalkyl ethers, 

C13-rich, phosphates, ethoxylated
CASRN AAAPD Chemical Name

9004-80-2 Poly(oxy-1,2-ethanediyl), a-phosphono-w-(decyloxy)-

91254-26-1

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono(C16 and C18-unsatd. 

alkyl) ethers, phosphates 

93925-54-3

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, monococo alkyl ethers, 

phosphates, sodium salts 

96416-89-6

Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-sec-alkyl 

ethers, phosphates, potassium salts 

AAASD Surfactants:

40CFR 180.910 and 180.930: α-Alkyl(C6-C15)-ω-hydroxypoly(oxyethylene) sulfate, and its 

ammonium, calcium, magnesium, potassium, sodium, and zinc salts, poly(oxyethylene) 

content averages 2-4 moles; used as surfactants not to exceed 30% of pesticide formulation.

CASRN AAASD Chemical Name

106597-03-9

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C13-15-branched alkyl ethers, 

sodium salts

110392-50-2

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-13-alkyl ethers, sodium 

salts

125301-88-4

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-14-alkyl ethers, 

ammonium salts

125301-89-5

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-15-alkyl ethers, 

ammonium salts

125301-92-0

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-15-alkyl ethers, sodium 

salts

125736-54-1

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-14-sec-alkyl ethers, 

sodium salts

157707-85-2

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C6-12-alkyl ethers, sodium 

salts

160104-51-8

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-14-alkyl ethers,

magnesium salts

160901-27-9

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-branched and linear 

alkyl ethers, ammonium salts

160901-28-0

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-branched and linear 

alkyl ethers, sodium salts

160901-29-1

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C11-14-branched and linear 

alkyl ethers, sodium salts

160901-30-4

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-15-alkyl ethers, sodium 

salts

161025-28-1 Alcohols, C6-12, ethoxylated, sulfates, sodium salts

161074-79-9 Alcohols, C12-13, branched and linear, ethoxylated, sulfates, sodium salts 

162063-19-6

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C13-15-branched and linear 

alkyl ethers, sodium salts

27140-00-7 Ethanol, 2-[2-(dodecyloxy)ethoxy]-, 1-(hydrogen sulfate), ammonium salt 

27731-61-9 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tetradecyloxy)-, ammonium salt (1:1) 
27731-62-0 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tetradecyloxy)- sodium salt (1:1) 

34431-25-9 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(octyloxy)-, sodium salt (1:1)

35015-74-8 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(pentadecyloxy)-, sodium salt (1:1) 

52286-18-7 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(octyloxy)-, ammonium salt (1:1) 

52286-19-8 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(decyloxy)-, ammonium salt

54116-08-4 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tridecyloxy)-, sodium salt

61702-79-2 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tridecyloxy)-, ammonium salt (1:1)

63428-86-4 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(hexyloxy)-, ammonium salt (1:1)

63428-87-5 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(decyloxy)-, sodium salt (1:1)

65086-57-9 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(decyloxy)-

65086-79-5 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tetradecyloxy)-

67674-66-2 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(pentadecyloxy)-

67845-82-3 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(octyloxy)-

67845-83-4 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(pentadecyloxy)-, ammonium salt 

68037-05-8

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C6-10-alkyl ethers, ammonium 

salts

68037-06-9 Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C6-10-alkyl ethers

68171-41-5 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(hexyloxy)-

68610-66-2

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C10-12-alkyl ethers, sodium 

salts

68649-53-6

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-13-alkyl ethers, 

ammonium salts

68890-88-0

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C10-12-alkyl ethers, 

ammonium salts

68891-29-2

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C8-10-alkyl ethers, ammonium 

salts

68891-30-5

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C11-15-branched alkyl ethers, 

ammonium salts

69011-37-6

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C8-14-alkyl ethers, ammonium 

salts

75422-21-8

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C6-12-alkyl ethers, ammonium 

salts

78330-17-3 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(hexyloxy)-, branched, sodium salt

78330-16-2 Poly(oxy-1,2-ethanediyl), a-sulfo-w-(hexyloxy)-, branched, ammonium salt

78330-25-3

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C7-9-isoalkyl ethers, C8-rich, 

ammonium salts

78330-26-4

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-isoalkyl ethers, C10-

rich, ammonium salts

78330-27-5

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C11-14-isoalkyl ethers, C13-

rich, ammonium salts

78330-28-6

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C7-9-isoalkyl ethers, C8-rich, 

sodium salts

78330-29-7

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-isoalkyl ethers, C10-

rich, sodium salts

78330-30-0 Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C11-14-isoalkyl ethers, C13-
rich, sodium salts

9021-91-4 Poly[oxy(methyl-1,2-ethanediyl)], a-sulfo-w-(octyloxy)-, sodium salt (1:1) 

96130-61-9

Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-alkyl ethers, sodium 

salts

in or on all raw agricultural commodities. [Prior to the submission of this petition to add 

missing CASRNs, Petition PP 9E7533 (Document ID EPA-HQ-OPP-2009-0131) was 

submitted to the Agency and these CASRNs were missing from the petition. JITF CST2 is 

relying on the information submitted in 9E7533 to support this petition which includes the 

exact same chemistries. JITF CST2 does not expect the addition of these CASRNs to result 

in additional exposure or risk.] EPA has determined that the petition contains data or 

information regarding the elements set forth in section 408 (d)(2) of FFDCA; however, EPA has 

not fully evaluated the sufficiency of the submitted data at this time or whether the data supports 

granting of the petition. Additional data may be needed before EPA rules on the petition.

A. Residue Chemistry

1. Plant metabolism. [Not Applicable]

2. Analytical method. [Not Applicable]

3. Magnitude of residues. [There is no specific crop residue information available for 

AAAPD and AAASD and this information is typically not available nor required for the 

establishment of a tolerance exemption for inert ingredients.] 

B. Toxicological Profile

1. Acute toxicity. [AAAPD and AAASD are likely skin/eye irritants in their 

undiluted forms, but not acutely toxic. The reported oral LD50 values were higher than 

1,600 mg/kg for the alkyl ether phosphates C13EO3,6,12P, CASRN 9046-01-9 and alkyl ether 

sulfates NaC12EO3S, CASRN 9004-82-4 (Category III). No effects were found at any of the 

concentrations tested dermally.]

2. Genotoxicity. [NaC12-15EO2-3S compounds were not mutagenic in bacterial or 

mammalian in vitro cell systems or in vivo (HERA 2003). Neither IARC, NTP nor OSHA 

listed as a carcinogen.]

3. Reproductive and developmental toxicity. [One representative compound for the 

group of chemicals requested in 9E7533 (and 2E8092) is CASRN 68891-38-3 Poly(oxy-1,2-

ethanediyl), a-sulfo-w-hydroxy-, C12-14-alkyl ethers, sodium salts. The studies with the 

sulfate derivatives (AAASD) showed little to no toxicity in the dams or the pups, with the 

NOEL in a developmental toxicity study in rats with CASRN 68891-38-3 at the limit dose 

of 1000 mg/kg/day, and a reproductive NOAEL of 0.3% in drinking water, equivalent to 

300 mg/kg/day, the highest dose tested, in a two-generation reproduction study with 

CASRN 68891-38-3). 

CASRN 68891-38-3 was evaluated for effects on the reproduction and prenatal/postnatal 

development of the rat when administered orally via the drinking water through two 

successive generations. No reproductive or developmental effects were observed at any 
dose, even where corresponding parental toxicity was observed. The NOAEL for 

reproductive effects was 0.3% in drinking water, equivalent to 300 mg/kg/day, the highest 

dose tested. 

In studies with the phosphate derivatives (AAAPD), the reproductive/developmental NOEL 

for the OECD 422 study with CASRN 68130-47-2 was 800 mg/kg/day, the highest dose 

tested, and for CASRN 78330-24-2 the NOEL was 200 mg/kg/day.

4. Subchronic toxicity. [Based on the Federal Register Notice (August 9, 2006, 

Volume 71, Number 153, pages 45415-45424), the Agency stated that the preferred test for 

repeat-dose toxicity is the “Combined Repeated Dose Toxicity Study with the 

Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 422).”

AAAPD (CASRN 68130-47-2 and CASRN 78330-24-2) have been tested in repeat dose 

studies (OECD 422 Combined Repeated Dose Toxicity Study with a 

Reproduction/Developmental Toxicity Screening Test). The paternal and maternal 

NOAEL for CASRN 68130-47-2 was 200 mg/kg/day. The paternal and maternal noobservable-effect-level (NOEL) for CASRN 78330-24-2 was 200 mg/kg/day. The NOAEL 

of 200 mg/kg/day was selected as the toxicology endpoint for the chronic risk assessment 

for the phosphate derivatives (AAAPD).

Subchronic data have been found in the public domain for the AAASD. Subchronic 21-

day repeat dose dietary studies showed low toxicity of compounds with carbon lengths of 

C12-15, C12-14 and C13-15 with sodium or ammonium alkyl ethoxylates with POE n=3. One 

study indicated that C16-18 POE n=18 had comparable low toxicity. No-observed-adverseeffect levels (NOAELs) range from 120 to 468 mg/kg/day, similar to a NOAEL from a 90-day 

rat gavage study with NaC12-14 POE n=2(CASRN 68891-38-3), which was reported to be 225 

mg/kg/day. In addition, another 90-day repeat dose dietary study with NaC12-15 POE 

n=3(CASRN 68424-50-0) resulted in low toxicity, with a NOAEL of greater than 

approximately 50 mg/kg/day (calculated based on dose of 1000 ppm in diet). Effects were 

usually related to hepatic hypertrophy, increased liver weight, and related increases in 

hematological endpoints related to liver enzyme induction.

Henkel KgaA (1994a) evaluated CASRN 68891-38-3 for systemic toxicity in Wistar 

(Hsd/Win:WU) rats by gavage at doses of 0, 25, 75, and 225 mg/kg/day for 90-days. No 

treatment related symptoms including changes in mean food consumption or water intake, 

total body weight gain, hematological examinations, clinical chemistry, absolute and 

relative organ weights and macroscopical examinations were observed in any group. 

According to systemic, behavioral, and clinical abnormalities the NOAEL of 225 mg/kg/day 

for sodium lauryl ether sulfate was determined.

CASRN 68891-38-3 was evaluated for effects on the reproduction and prenatal/postnatal 

development of the rat when administered orally via the drinking water through two 

successive generations. Based on this study an overall no-observed-adverse-effect level 

(NOAEL) for systemic effects was 0.1%, which was 86.6 mg/kg/day for the F0 generation, 

and 149.5 mg/kg/day for the F1 generation. The NOAEL of 86.6 mg/kg/day was selected as 

the toxicology endpoint for the chronic risk assessment for the sulfate derivatives 

(AAASD).]
5. Chronic toxicity [Based on the Federal Register Notice (August 9, 2006, Volume 

71, Number 153, pages 45415-45424), the Agency stated that the preferred test for repeatdose toxicity is the “Combined Repeated Dose Toxicity Study with the 

Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 422).” 

Chronic dietary studies conducted with rats on AAASDs showed no incidence of cancer 

and no effects at the concentrations tested (lowest dose tested was ca 75 mg/kg/day).] 

6. Animal metabolism. [The mammalian metabolic pathway for AAASD type 

surfactants has been published. The mammalian metabolic pathway for AAASD type 

surfactants has been published (HERA, 2003). For compounds of comparable C16 carbon 

chain, the metabolites of the lower molecular weight ethoxylated (POE n=3) AAASD 

surfactants are readily absorbed and excreted primarily in the urine whereas for the C16 

AAASD surfactants with increased ethoxylation (POE n=9) are poorly absorbed and 

excreted primarily in the feces (McDermott et al., 1975). There was also no evidence of 

hydrolysis of the sulfate group from C16 POE n= 3 and C16 POE n=9 or of metabolism of 

the ethoxylate portion of the molecule. With C11 POE n=3 and C12 POE n=3 metabolic 

studies in rats confirmed that the alkyl chain is extensively metabolized by beta- or omegaoxidation leaving the ethoxysulfate, which is excreted directly (Taylor et al., (1978)

By analogy to what would generally be expected in the metabolism for phosphate 

esters, the AAAPD surfactants may initially undergo metabolism to generate the 

corresponding AAA and POE (or POE/POP) phosphate glycol. By analogy to the 

reported metabolism for the CST1 Alkyl Alkoxylate Alcohol (AAA) surfactants, the 

dephosphoralyted metabolite should be hydrolyzed to the POE (or POE/POP) 

polyalkoxylate glycols and linear branched saturated and unsaturated alkyl alcohol 

metabolites. The resultant alkyl alcohol metabolites would be oxidized in fatty acid 

oxidation pathways. The polyalkoxylate glycols may either be conjugated and 

excreted unchanged or hydrolyzed/oxidized to various degraded metabolites before 

being conjugated and excreted.] 

7. Metabolite toxicology. [No metabolites of toxicological concern are expected based 

on the proposed animal metabolic pathway.]

8. Endocrine disruption. [The AAAPD and AAASD surfactants do not belong to a 

class of chemicals known or suspected of having adverse effects on the estrogen receptor or 

endocrine system. AAAPD and AAASD have been evaluated in acute, subchronic, 

developmental and reproductive studies capable of detecting effects on endocrine mediated 

events. The results of these studies did not give any indication of a treatment-related effect 

on the estrogen receptor or endocrine system.]

C. Aggregate Exposure

1. Dietary exposure. [The dietary (food plus drinking water) exposures for AAAPD 

and AAASD surfactants are expressed as a percentage of the proposed chronic population 

adjusted dose (cPAD) for the general US population and children 1-2 years old, the 

subpopulation with the highest potential exposures. 
Based on I-DEEM screening level calculations, the chronic dietary exposures for the 

AAAPD are estimated to be 6% of the cPAD for the general U.S. population and 21% of 

the cPAD for children 1-2 years old. 

Based on I-DEEM screening level calculations, the chronic dietary exposures for the 

AAASD are estimated to be 14% of the cPAD for the general U.S. population and 49% of 

the cPAD for children 1-2 years old. 

These data demonstrate that the I-DEEM screening level chronic dietary (food and 

drinking water) exposures for both the AAAPD and AAASD are well below 100% of the 

cPAD, and are therefore below EPA’s established level of concern for all U.S. 

subpopulations.

On the basis of the OECD 422 repeat dose toxicity study and comparison of I-DEEM 

exposures to the proposed cPAD, the JITF CST2 asserts that there is sufficient basis for 

EPA to grant a tolerance exemption for these additional AAAPD and AAASD surfactant 

CASRNs. 

CHRONIC DIETARY SAFETY ASSESSMENT, % cPAD

Study

Chronic 

Systemic 

NOAEL 1

mg/kg 

bw/day

cPAD2

mg/kg 

bw/day 

Percent 

cPAD 

Children 

1-2 years 

of age

Percent 

cPAD 

U.S. Gen 

Population

AAAPD CASRN 68130-47-2

and CASRN 78330-24-2; 

Repeated Dose Toxicity with 

Reproduction/

Developmental Toxicity 

Screening in Rats- (OECD 

422) 

AAASD Sulfate CASRN 

68891-38-3; systemic 

toxicity endpoint for 

repeated dose from the two 

generation rat reproductive 

drinking water study

200

87

2.0

0.87

21%

49%

6%

14%

Note:

1 NOAEL – No observed adverse effect level

2

cPAD – Chronic population adjusted dose, defined as: chronic NOAEL / (safety factor 

FQPA factor)

i. Food. [The available data demonstrate that the I-DEEM screening level chronic 

dietary (food and drinking water) exposures are well below 100% of the cPAD, and are 

therefore below EPA’s established level of concern for all U.S. subpopulations.]
ii. Drinking water. [Drinking water is included in the I-DEEM exposure assessment. 

Exposure to AAAPD and AAASD via drinking water is expected to be negligible.]

2. Non-dietary exposure. [AAAPD and AAASD surfactants are used as inert 

ingredients in agricultural formulations as well as in non-pesticidal uses such as, personal 

care products household cleaning products and laundry detergents. Given the low estimate 

of dietary exposure, there is ample room in the overall aggregate MOE for non-dietary 

uses.]

D. Cumulative Effects

[For the purpose of the tolerance exemption actions cited herein, the JITF CST2 has 

assumed that the AAAPD and AAASD will not have a common mechanism of toxicity with 

other surfactant substances. It is therefore appropriate to consider only the potential risks 

of the compounds included in CST2 in the exposure assessment.]

E. Safety Determination

1. U.S. population. [A dietary exposure assessment using current EPA inert 

screening level methodology (I-DEEM) was conducted. Based on the conservative I-DEEM 

dietary exposure estimates, there is a reasonable certainty that no harm will result to the 

US population from the aggregate exposure to AAAPD and AAASD.]

2. Infants and children. [The FFDCA Section 408 requires an additional tenfold 

margin of safety for the protection of infants and children in case of threshold effects to 

account for prenatal and postnatal toxicity, and an inadequate toxicity database. Where an 

adequate and reliable database is available and there is a lack of evidence for increased 

susceptibility, the FQPA safety factor may be reduced or removed. An evaluation of 

susceptibility and uncertainty issues associated with Anionic Alkyl Alkoxylate Derivatives 

has been performed. Based on the points below, the JITF CST2 recommends that the 

FQPA safety factor be reduced from the default 10X to 1X. 

 A scientifically sound mammalian toxicology database, which includes acute, 

subchronic, reproductive, and developmental toxicity data, indicates no adverse effects 

to sensitive populations.

 The AAAPD and AAASD surfactants do not belong to a class of chemicals known or 

suspected of having adverse effects on the estrogen receptor or endocrine system. These 

surfactants have been evaluated in acute, subchronic, developmental and reproductive 

studies capable of detecting effects on endocrine mediated events. 

 The AAASDs have also been evaluated in chronic studies including a two year dietary 

study (Moore 1983) and a two generation reproduction study with drinking water 

(Henkel KGaA 1999, MRID 470609903, 47112401).

 OECD 422 testing and other reproduction and developmental studies available in the 

literature (HERA, 2003) indicates no reproductive and no developmental effects in 

offspring at levels that are not maternally toxic. 

 There was no evidence of effects on the nervous system in the acute, subchronic or 

reproduction studies.] 

F. International Tolerances
[There are no known international tolerances for Alkyl Alcohol Alkoxylate 

Phosphate and Sulfate Derivatives.]