EX-10.47.1



 Exhibit 10.47.1 

FIRST LOAN MODIFICATION AGREEMENT 

This First Loan Modification Agreement (this “Loan Modification Agreement”) is entered into as of
December 22, 2016, by and between SILICON VALLEY BANK, a California corporation (“Bank”), and MIRAGEN THERAPEUTICS, INC. a Delaware corporation (“Borrower”). 

1. DESCRIPTION OF EXISTING INDEBTEDNESS AND OBLIGATIONS. Among other indebtedness and obligations which may be owing by Borrower to
Bank, Borrower is indebted to Bank pursuant to a loan arrangement dated as of April 30, 2015, evidenced by, among other documents, a certain Loan and Security Agreement, dated as of April 30, 2015, between Borrower and Bank (as amended,
the “Loan Agreement”). Capitalized terms used but not otherwise defined herein shall have the same meaning as in the Loan Agreement. 

2. DESCRIPTION OF COLLATERAL. Repayment of the Obligations is secured by the Collateral as described in the Loan Agreement (together
with any other collateral security granted to Bank, the “Security Documents”). Hereinafter, the Loan Agreement, together with all other documents executed in connection therewith evidencing, securing or otherwise relating to the
Obligations shall be referred to as the “Existing Loan Documents”. 
 3. DESCRIPTION OF CHANGE IN TERMS. 

 

	 	A.	 Modifications to Loan Agreement. 



 

	 	1	 The Loan Agreement shall be amended by deleting the following definition appearing in Section 13.1
thereof: 


 “Availability Trigger” is, at any time after the Effective Date, the date on
which (i) Borrower provides Bank evidence reasonably satisfactory to Bank that Borrower has achieved mechanistic proof of concept for Borrower’s MRG-106 Phase I clinical trial; and (ii) Bank
receives a satisfactory update from Borrower’s investors, in form and substance reasonably acceptable to Bank. 

“Draw Period” is the period of time commencing on the date the Availability Trigger occurs through the
earlier to occur of (a) December 31, 2016 or (b) an Event of Default. 
 “Prime Rate” is the rate
of interest per annum from time to time published in the money rates section of The Wall Street Journal or any successor publication thereto as the “prime rate” then in effect; provided that if such rate of interest, as set forth from time
to time in the money rates section of The Wall Street Journal, becomes unavailable for any reason as determined by Bank, the “Prime Rate” shall mean the rate of interest per annum announced by Bank as its prime rate in effect at its
principal office in the State of California (such Bank announced Prime Rate not being intended to be the lowest rate of interest charged by Bank in connection with extensions of credit to debtors). 

and inserting in lieu thereof the following: 

“Availability Trigger” is, at any time after the First Loan Modification Effective Date, the date on which
Borrower provides Bank evidence reasonably satisfactory to Bank that Borrower has received net proceeds from the issuance of additional equity of Borrower of at least Thirty Five Million Dollars ($35,000,000), issued to investors of similar
character and quality as the investors in existence as of the Effective Date and otherwise reasonably acceptable to Bank. 

“Draw Period” is the period of time commencing on the date the Availability Trigger occurs through the
earlier to occur of (a) July 31, 2017 or (b) an Event of Default. 
 “Prime Rate” is the rate of
interest per annum from time to time published in the money rates section of The Wall Street Journal or any successor publication thereto as the 







 
“prime rate” then in effect; provided that, in the event such rate of interest is less than zero, such rate shall be deemed to be zero for purposes of this Agreement; and
provided further that if such rate of interest, as set forth from time to time in the money rates section of The Wall Street Journal, becomes unavailable for any reason as determined by Bank, the “Prime Rate” shall mean the
rate of interest per annum announced by Bank as its prime rate in effect at its principal office in the State of California (such Bank announced Prime Rate not being intended to be the lowest rate of interest charged by Bank in connection with
extensions of credit to debtors); provided that, in the event such rate of interest is less than zero, such rate shall be deemed to be zero for purposes of this Agreement. 
  

	 	2	 The Loan Agreement shall be amended by inserting the following new definitions in Section 13.1 thereof,
in its applicable alphabetical order: 


 “First Loan Modification Effective Date” is
December 22, 2016. 
 4. CONDITIONS PRECEDENT. Borrower hereby agrees that the following documents shall be delivered to the
Bank prior to or concurrently with the execution of this Loan Modification Agreement, each in form and substance satisfactory to the Bank (collectively, the “Conditions Precedent”): 

 

	 	A.	 copies, certified by a duly authorized officer of Borrower, to be true and complete as of the date hereof, of
each of (i) the governing documents of Borrower as in effect on the date hereof (but only to the extent modified since last delivered to the Bank), (ii) the resolutions of Borrower authorizing the execution and delivery of this Loan
Modification Agreement, the other documents executed in connection herewith and Borrower’s performance of all of the transactions contemplated hereby (but only to the extent required since last delivered to Bank), and (iii) an incumbency
certificate giving the name and bearing a specimen signature of each individual who shall be so authorized on behalf of Borrower (but only to the extent any signatories have changed since such incumbency certificate was last delivered to Bank);



  

	 	B.	 a duly executed copy of the update Perfection Certificate; 



 

	 	C.	 updated evidence of insurance; and 



 

	 	D.	 such other documents as Bank may reasonably request. 



5. FEES. Borrower shall reimburse Bank for all legal fees and expenses incurred in connection with the Existing Loan Documents and this
Loan Modification Agreement. 
 6. ADDITIONAL COVENANTS. Borrower hereby certifies that, other than as disclosed in the Perfection
Certificate, no Collateral with a value greater than Fifty Thousand Dollars ($50,000) in the aggregate is in the possession of any third party bailee (such as at a warehouse). In the event that Borrower, after the date hereof, intends to store or
otherwise deliver the Collateral with a value in excess of Fifty Thousand Dollars ($50,000) in the aggregate to such a bailee, then Borrower shall first receive, the prior written consent of Bank and such bailee must acknowledge in writing that the
bailee is holding such Collateral for the benefit of Bank. 
 7. CONSISTENT CHANGES. The Existing Loan Documents are hereby amended
wherever necessary to reflect the changes described above. 
 8. RATIFICATION OF LOAN DOCUMENTS. Borrower hereby ratifies, confirms,
and reaffirms all terms and conditions of the Loan Agreement and each other Loan Document, and of all security or other collateral granted to the Bank, and confirms that the indebtedness secured thereby includes, without limitation, the Obligations.

 9. NO DEFENSES OF BORROWER. Borrower hereby acknowledges and agrees that Borrower has no offsets, defenses, claims, or
counterclaims against Bank with respect to the Obligations, or otherwise, and that if Borrower now has, or ever did have, any offsets, defenses, claims, or counterclaims against Bank, whether known or unknown, at law or in equity, all of them are
hereby expressly WAIVED and Borrower hereby RELEASES Bank from any liability thereunder. 

  
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 10. CONTINUING VALIDITY. Borrower understands and agrees that in modifying the existing
Obligations, Bank is relying upon Borrower’s representations, warranties, and agreements, as set forth in the Existing Loan Documents. Except as expressly modified pursuant to this Loan Modification Agreement, the terms of the Existing Loan
Documents remain unchanged and in full force and effect. Bank’s agreement to modify certain terms and conditions pursuant to this Loan Modification Agreement in no way shall obligate Bank to make any future modifications to the Obligations.
Nothing in this Loan Modification Agreement shall constitute a satisfaction of the Obligations. It is the intention of Bank and Borrower to retain as liable parties all makers of Existing Loan Documents, unless the party is expressly released by
Bank in writing. No maker will be released by virtue of this Loan Modification Agreement. 
 11. JURISDICTION/VENUE. Section 11
of the Loan Agreement is hereby incorporated by reference. 
 12. COUNTERSIGNATURE. This Loan Modification Agreement shall become
effective only when it shall have been executed by Borrower and Bank. 
 [Signature page follows.] 

  
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 This Loan Modification Agreement is executed as of the date first written above. 

BORROWER: 
  

			
	 MIRAGEN THERAPEUTICS, INC.

		
	 By
	 	 /s/ Jason A. Leverone

	 Name:
	 	 Jason A. Leverone

	 Title:
	 	 CFO

	
	 BANK:

	
	 SILICON VALLEY BANK

		
	 By
	 	 /s/ Tom Hertzberg

	 Name:
	 	 Tom Hertzberg

	 Title:
	 	 Director



  
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