Amendment No.1 to the Warrant


 Exhibit 4.16 
  
 AMENDMENT NO. 1 TO 
 WARRANT 
  
 THIS AMENDMENT NO. 1 TO WARRANT
(this “Amendment”) made effective as of the 11th day of February, 2005 (the “Effective Date”) by and among Boston Life Sciences, Inc., a Delaware corporation (the “Company”) and Nikolaos D. Monoyios
(the “Holder”). 
  
 WITNESSETH: 

 
 WHEREAS, the Company issued to the Holder that certain Warrant for
the Purchase of 820,123 Shares of Common Stock (Warrant No. BLSI–2002-55) on November 22, 2002 (the “Warrant”); and 
  
 WHEREAS, the Company and the Holder desire to amend the Warrant to reflect mutually agreed upon revised terms in accordance with the provisions of
this Amendment. 
  
 NOW, THEREFORE, in consideration of the
mutual covenants and agreements set forth herein and for good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the Company and the Holder agree as follows: 
  
 1. Definitions. 
  
 Capitalized terms used herein, but not otherwise defined, shall have the
meanings ascribed to them in the Warrant. 
  
 2.
Amendments. 
  
 The first two sentences of the preamble of
the Warrant are hereby deleted in their entirety and amended and restated to read as follows: 
  
 “FOR VALUE RECEIVED, BOSTON LIFE SCIENCES, INC., a Delaware corporation (the “Company”), hereby certifies that Nikolaos D. Monoyios, or its permitted assigns, is entitled to purchase from
the Company, at any time or from time to time, commencing on November 22, 2002 (the “Initial Exercise Date”), 820,123 fully paid and non-assessable shares of the Common Stock, $.01 par value per share, of the Company. This
Warrant shall expire at 5:00 P.M., New York City time, on December 31, 2006 (the “Termination Date”), and is exercisable for 820,123 fully paid and non-assessable shares of the Common Stock, $.01 par value per share,
of the Company for an aggregate purchase price of $369,055 computed on the basis of $0.45 per share, which amounts do not reflect the 1-for-5 reverse stock split effected by the Company on February 4, 2005.” 






 3. Reference to and Effect on the Warrant. 
  
 (a) On and after the Effective Date, each reference to “this
Warrant,” “hereunder,” “hereof,” “herein,” or words of like import shall mean and be a reference to the Warrant as amended hereby. No reference to this Amendment need be made in any instrument or document at any
time referring to the Warrant, a reference to the Warrant in any of such instrument or document to be deemed to be a reference to the Warrant as amended hereby. 
  

(b) Except as expressly amended by this Amendment, the provisions of the Warrant shall remain in full force and effect. 
  
 4. Agreement to Exercise. 
  
 In consideration of the amendments set forth in Section 2 hereof, the Holder
agrees to exercise the Warrant in whole (and not in part) and deliver proper payment of the Aggregate Warrant Price to the Company in cash no later than February 11, 2005. 
  
 5. Governing Law. 
  
 This Amendment shall be governed by, and construed and enforced in accordance with the internal laws of The Commonwealth of Massachusetts applicable to
contracts made and performed within such Commonwealth, without giving effect to the conflicts of laws principles thereof. 
  
 6. Counterparts. 
  
 This Amendment may be executed by facsimile in one or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute a single instrument. 
  
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 IN WITNESS WHEREOF, the undersigned have caused this Amendment to be executed and delivered on the
date first written above. 
  

			
	 BOSTON LIFE SCIENCES, INC.

		
	 By:
	 	 /s/ Joseph Hernon


	 	 	 Joseph Hernon

	 	 	 Chief Financial Officer

		
	 	 	 /s/ Nikolaos D. Monoyios


	 	 	 Nikolaos D. Monoyios



  
 [Signature
Page to Amendment No. 1 to Warrant]