EPA BIOPESTICIDES AND POLLUTION PREVENTION DIVISION COMPANY 

NOTICE OF FILING FOR PESTICIDE PETITIONS PUBLISHED IN THE FEDERAL 

REGISTER 

EPA Biopesticides and Pollution Prevention 

TEMPLATE

Natural Industries, Inc.

Petition Number: 9F7587

EPA has received a pesticide petition (9F7587) from Natural Industries, Inc., 

6223 Theall Rd., Houston, TX 77066 proposing, pursuant to section 408(d) of the 

Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR 

part 180 to establish an exemption from the requirement of a tolerance for the microbial 

pesticide Paecilomyces fumosoroseus strain FE 9901 in or on vegetable and herb 

crops.

Pursuant to section 408(d)(2)(A)(i) of FFDCA, as amended, Natural Industries, 

Inc. has submitted the following summary of information, data, and arguments in 

support of their pesticide petition. This summary was prepared by Natural Industries, 

Inc. and EPA has not fully evaluated the merits of the pesticide petition. The summary 

may have been edited by EPA if the terminology used was unclear, the summary 

contained extraneous material, or the summary unintentionally made the reader 

conclude that the findings reflected EPA’s position and not the position of the petitioner.

I. Natural Industries, Inc. Petition Summary (9F7587)

A. Product Name and Proposed Use Practices: NoFlyTM WP a mycoinsecticide 

to control whiteflies on agricultural food crops grown in greenhouses. 

B. Product Identity/Chemistry: Identity of the pesticide and corresponding 

residues. Paecilomyces fumosoroseus strain FE 9901 is a naturally 

occurring fungus occurring in various soil types. Residues of Paecilomyces 

fumosoroseus strain FE 9901 are not expected to occur since the organism 

degrades rapidly in sunlight and high temperatures. Any remaining residues 

are removed from post harvest washing and treatments. 
2

C. Mammalian Toxicological Profile: Acute toxicity/pathogenicity studies 

conducted with NoFlyTM Technical (60.0% active ingredient) showed no 

adverse effects by any route of exposure. Paecilomyces fumosoroseus 

strain FE 9901 can’t grow and develop at human and other mammal body 

temperatures (35 ̊C or above). Additionally, acute pulmonary and acute 

injection toxicity studies showed that Paecilomyces fumosoroseus strain FE 

9901 is not pathogenic, not infectious and showed minimal persistence in 

rats. 

D. Aggregate Exposure. Dietary exposure: food. Residues of Paecilomyces 

fumosoroseus strain FE 9901 are not expected to occur since it degrades 

rapidly in sun light and in high temperatures, which are common in 

greenhouses. Any remaining residues will wash off during the processing of 

the food.

E. Cumulative Effects: No cumulative effects from the use of Paecilomyces 

fumosoroseus strain FE 9901 on food crops since the organism can’t grow 

or persist at temperature above 35 ̊C or above. 

F. Safety Determination

1. U.S. population. There are no safety concerns for using Paecilomyces 

fumosoroseus strain FE 9901 on food crops on the U.S. population. The 

organism can’t grow or infect humans and does not persist in 

temperatures above 35 ̊C. The organism also rapidly degrades in sunlight. 

Any remaining microorganisms will be washed off with common food 

processing procedures. 

2. Infants and children. There are no safety concerns for using 

Paecilomyces fumosoroseus strain FE 9901 on food crops for infants and 

children. The organism can’t grow or infect humans and does not persist in 

temperatures above 35 ̊C. The organism also rapidly degrades in sunlight. 

Any remaining microorganisms will be washed off with common food 

processing procedures. 

G. Effects on the Immune and Endocrine Systems: There are no reported 

adverse effects to the immune or endocrine systems from Paecilomyces 

fumosoroseus strain FE 9901. 

H. Existing Tolerances: There are no existing tolerances for Paecilomyces 

fumosoroseus strain FE 9901 in the United States.

I. International Tolerances: There are no existing international tolerances for 

Paecilomyces fumosoroseus strain FE 9901.