Acetamiprid Dietary Exposure Assessment DP No.: 372890

PC Code: 099050



### Page 1 of 28

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES 

### MEMORANDUM DATE: Jan 1 4 , 2010 SUBJECT: Acetamiprid

. Revised A cute and Chronic Dietary Exposure Assessments (Food

and Drinking Water) to Support Section 3 Registration of Uses on Clover, Small Vine Climbing Fruits, except Fuzzy Kiwifruit, Subgroup 13

- 07F, Greenhous e Grown Tomatoes and Tea.

PC Code: 099050 DP Barcode: D 372890 Decision N o.: 408298 Registration No s . : 8033

- 23, 8033

- 36, 8033

- 94 Petition No.: 9E7544 Regulatory Action: Amended Section 3 Risk Assessment Type: Single Chemical Aggregate, Dietary Case No.: N/A
T XR No.: N/A CAS No.: 135410

- 20

- 7 MRID No s .: N/A 40 CFR: §180.578

REVIEWER: Dennis McNeill y , Chemist

Registration Action Branch 2 Health Effects Division (7509 P )
THROUGH: Julie Van Alstine , MPH, Environmental Health Scientist

Douglas Dotson , Ph.D., Chemist Dietary Exposure Science Advisory Council (DESAC) H ealth Effects Division (7509 P )
TO: Laura Nollen, Risk Manager Reviewer

Barbara Madden, Team Leader (RM Team 5) RIMUERB/Registration Division (RD) (7505P)
Executive Summary Acute and chronic dietary (food + drinking water) risk assessments were conducted using the Dietary Exposure Evaluation Model (DEEM

- FCIDTM, Version 2.03) which use s foodAcetamiprid Dietary Exposure Assessment DP No.: 372890

PC Code: 099050



### Page 2 of 28 consumption data from the USDA’s Continuing Survey s of Food Intakes by Individuals (CSFII, 1994

- 1996 and 1998). A naly ses were previousl y performed to support the requested Section 3 registration of acetamiprid o n clover, s mall v ine c limbing f ruits, except kiwifruit, s ubgroup 13

- 07F (amending grape use) ; green house grown tomatoes ; and tea (D369019, D. McNeill y, 12/1/2009)

. RD has requested that HED redo the anal ys es using 100% percent crop treated for all amende d commodities, i.e., grapes and other subgroup 13

- 07F commodities, and tomatoes

. Acute Dietary

(Food and Drinking Water) Exposure Results and Characterization The probabilistic acute dietary exposure assessment included tolerance level residues, anticip ated residues from field residue trials, processing factors, maximum percent crop treated ( %CT ) estimates (for existing uses only) generated b y the Biological and Economic Anal ys is Division (BEAD), and the modeled peak concentration of acetamiprid residues in surface and groundwater water sources of drinking water. Although the acute assessment has been refined, the resulting exposure estimates are still considered to be conservative since field trial data were the basis for the anticipated residues, and b ecause a conservative drinking water model (FIRST) was used to estimate residues in drinking water. Acute dietary

exposure estimates at the 99.9 th 

### percentile are below HED’s level of concern for the general US population and all other population subgroups . For the US population, the estimated exposure of 0.0 2 4 mg/kg/day corresponds to 2 4 % aPAD; for children 1

- 2 years old, the estimated exposure of 0.0 4 3 mg/kg/day corresponds to an acute dietary risk of 4 3 % aPAD. Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization For the chronic anal ys is, tolerance

- level residues were assumed for all food commodities with existing and proposed acetamiprid tolerances . Percent crop treated was used for man y commodities as detailed in Table 3

. The chronic analy sis also included the modeled surface water annual average residue in drinking water. Even though %CT information was used in the chronic analy sis, the exposure and risk estimates are still conservative since tolerance level residues wer e used, because 100 %CT was assumed for crops where percent crop treated information was not available, and because a conservative drinking water model (FIRST) was used. Chronic dietary

exposure to acetamiprid, including existing and proposed uses, is bel ow HED’s level of concern for the US population and all other population subgroups. For the general US population, an estimated exposure of 0.00 2 8 mg/kg/day corresponds to 4 % of the chronic population adjusted dose ( cPAD ) ; children 1

- 2 years old w as the h ighest exposed population subgroup, with an estimate of 0.0 1 0 mg/kg/day , or 1 5 % cPAD. Risks for all population subgroups are less than 100% cPAD, and are not of concern.
I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acuteAcetamiprid Dietary Exposure Assessment DP No.: 372890

PC Code: 099050



### Page 3 of 28 and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the popul ation adjusted dose (PAD). The PAD is equivalent to a point of departure (POD, NOAEL , LOAEL, e.g.) divided by the required uncertainty

or safet y factors. For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100 % of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July /Day

- 12/6061.pdf ; or see SOP 99.6 (8/20/99). The most recent dietary

risk assessment for acetamiprid was conducted b y D

. McNeill y (D 369019 , 1 2 / 1 / 0 9 ) which included proposed uses on clover, small vine climbing fruits, except kiwifruit, subgroup 13

- 07F (amending grape use); green house grown tomatoes; and tea. RD has requested that HED redo the anal ys es using 100% percent crop treated for all amende d commodities, i.e., grapes and other subgroup 13

- 07F commodities, and tomatoes

. II. Residue Information Tolerances are established for residues of the insecticide acetamiprid [40 CFR §180.578(a)], N1

- [(6

- chloro

- 3

- py

ridyl )methyl]

- N2

- cyano - N1

- methylacet amidine, in or on numerous agricultural commodities ranging from 0.01 ppm on mustard and canola seed to 20 ppm in or on cotton, gin by products

. Tolerances are established for the combined residues of the insecticide acetamiprid, N1

- [(6

- chloro

- 3

- py

ridyl )me thyl]

- N2

- cyano - N1

- methylacetamidine, and its metabolite N1

- [(6

- chloro

- 3

- py

ridyl )meth yl ]

- N2

- cyano - acetamidine [40 CFR §180.578(b)] in or on fat and meat of cattle, goat, hog, horse and sheep, 0.1 ppm; meat by

- products of cattle, goat, hog horse and sheep, 0.2 ppm; milk, 0.1 ppm; poultry meat and fat, 0.01 ppm; poultry liver, 0.05 ppm; and egg, 0.01 ppm. The current acute and chronic dietary exposure assessments include existing uses and the tolerances proposed b y the Interregional Research Project Number 4 (IR

- 4). IR

- 4 has submitted amended Section 3 registration requests for new uses of acetamiprid on clover grown for seed, small vine climbing fruits, except kiwifruit, subgroup 13

- 07F (amending established grape uses), greenhouse

- grown tomatoes , and tea

.
Table 1. Recommended Tolerances Crop Group or Commodity Recommended Tol. (ppm) Clover, forage* 0.10* * Tolerances with regional restrictions [i.e., 40 CFR §180.578(c)]. Clover, hay* 0.10* * Tolerances with regional restrictions [i.e., 40 CFR §180. 578(c)]. Fruit, small, vine climbing, subgroup 13

- 07F, except fuzzy kiwifruit 0.35Acetamiprid Dietary Exposure Assessment DP No.: 3 72890

PC Code: 099050



### Page 4 of 28 Table 1. Recommended Tolerances Crop Group or Commodity Recommended Tol. (ppm) Tea 50.0 Tomatoes (greenhouse grown) Note: No change is needed to the current tolerance in fruiting vegetables (Crop Group 8) at 0.2 ppm.


### Acute Dietary Exposure A ssessment The acute dietary

assessment was conducted using anticipated residues from field trials [apples; broccoli; cabbage, celery; grapefruit; grapes; lettuce; oranges; pears; peppers; spinach; tomatoes; stone fruit (crop group 12); and cucurbits (crop group 9)]. For each of the above

- listed commodities, the individual field trial residue values (from trials reflecting the 1X application rate and label ed PHI , or shorter) were incorporated into a residue distribution file ( RDF ) for the probabilistic acute dietary exposure assessment. For field trial residues below the limit of quantification (LOQ) of 0.01 ppm, a residue value of 1⁄2 LOQ, or 0.005 ppm was assumed. For cabbage and head lettuce, residues in the RDF were for the raw agricultural commodity ( RAC ) without wrapper leaves. For commodities with %CT data available, the RDF include s an indication of the number of zeroes assumed for the percent of the commodity not treated. Tolerance level or HED

- recommended tolerance level residues were use d for tr ee nuts, nectarines, collards, cauliflower, legumes, berries , bulb vegetables and for livestock commodities. For tea, the HED

- recommended tolerance of 50 ppm was used

. A summary

of the RDF s is included in Attachment 1. The orange RDF was translated to grapefruit, using the higher percent crop treated estimate of 5% for oranges (grapefruit was <2.5%). T he plum RDF was translated to apricots and assumes 100% CT

. These translations are appropriate since the field trials were conducted on the representativ e crops, and cover potential residues in the related crops , and since either no adjustment for %CT was made (plums and apricots) or a conservative estimate of %CT was made in these RDFs

. 100% crop treated was assumed for grapes and tomatoes because the us e pattern s are being amended for these commodities and projected crop treated estimate s are not available. Chronic Dietary Exposure Assessment For the chronic dietary

exposure assessment, current and recommended tolerance

- level residues were used, for al l RACs and livestock commodities. Percent crop treated estimates were used for apple ( 2 0%), broccoli (5%), cabbage ( 5 %), cauliflower (1 0 %), celery ( 2 5%), cotton (5%), grapefruit ( 2.5 %), lemon (5%), lettuce ( 1 0%), orange ( 2. 5%), peach ( 1 %), pear ( 35 %), pep per ( 2. 5%), potato ( 2.5 %), pumpkin ( 1 %), spinach (5%), and squash ( 2.5 %). 100% crop treated was assumed for grapes and tomatoes because the use pattern s are being amended for these commodities and projected crop treated estimate s are not available.Acetamiprid Dietary Exposure Assessment DP No.: 3 72890

PC Code: 099050



### Page 5 of 28 Pro cessing Factors The acute dietary

exposure assessment was refined with processing factors for apple juice, orange juice, grape fruit juice, raisins, dried prunes, tomato paste and tomato puree. The processing factors were reviewed in conjunction with resi due data used to determine if separate tolerances were needed for processed commodities. For all other commodities, the DEEMTM Version 7.8 1 default processing factors were used. Processing factors from study data were incorporated into the acute dietary

a ssessment as follows (Table 2 ):

Table 2 . Summary of Processing Studies Conducted with Acetamiprid. RAC Processed Commodity Processing Factor Comments Apple Juice 0.88 Also used for pear juice Citrus Juice <0.16 0.16X used for both orange and grapefrui t juice Grape Juice 1 Study data showed RAC tolerance would cover residues in juice. Raisins 0.9 0.9X used in assessment Tomato Puree 1.4 1.4X used for puree in assessment Paste 3.0 3.0 X used for paste in acute assessment. Plum Prune, dried 2.9X 2.0 X used for dried prunes used in acute assessment

. The drying factor was translated to dried apricots and dried peaches in the acute dietary assessment. 

### For the chronic dietary

exposure assessment, the DEEMTM Version 7.8 1 default processing factors were u sed for all commodities for which they are available , with the exception of grape juice, and raisins ( dried prunes and tomato paste have s eparate tolerance s )

. Usage Data In order to refine the dietary exposure estimates for acetamiprid, HED requested a S creening Level Usage Anal ys is (SLUA), which was conducted by the Biological and Economic Anal ys is Division (BEAD), 6 / 11/ 0 9 . The SLUA includes estimates of maximum %CT for the acute assessment and average %CT for determining chronic exposure. Commodities with the most significant acetamiprid usage in terms of maximum %CT include pears ( 60 %), apples ( 30 %), celery ( 4 5%), and lettuce ( 2 0%). Commodities with the most significant usage in terms of lbs ai applied include apples ( 10 ,000), cotton ( 20 ,000), and pe ars ( 5 ,000). The SLUA is included as Attachment 3.

Table 3. Percent Crop Treated Data Used in DEEM Comm odity Avg Max Apples 20 30 Broccoli 5 1 5Acetamiprid Dietary Exposure Assessment DP No.: 3 72890

PC Code: 099050



### Page 6 of 28 Table 3. Percent Crop Treated Data Used in DEEM Comm odity Avg Max Cabbage 5 10 Cauliflower 10 1 5 Celery 25 45 Cotton 5 5 Grapefruit 2.5 5 1 Lemons 5 100 Lettuce 10 2 0 Oranges 2.5 5 Peaches 1 2.5 Pears 35 60 Peppers 2.5 5 Potatoes 2.5 2. 5 Pum pkins 1 2.5 Spinach 5 15 Squash 2.5 2.5 1

- The residue distribution file for oranges which used 5% CT wa s also used for grapefruit . This was higher than the 2.5% CT fo r grapefruit e s timated by BEAD and is more conservative. 

### For the acute anal ys is, maximum %CT was incorporated into RDFs for the c ommodities in the above table

. For the chronic anal ys is, average %CT was included (as adjustment factor 2) for the commoditie s listed in the table above

. Incorporation of Potential Residues in Drinking Water In a memo dated 6/10/09 [D. L ieu, D364248], EFED notified RD that new drinking water estimates would not be provided for the proposed use on red clover (grown for seed onl y), grape, and tomato (greenhouse) because the drinking water estimates derived from the uses on citrus and tree nuts reflect the maximum use patterns for acetamiprid. In conjunction with th e uses on citrus and tree nuts , the Environmental Fate and Effect s Division (EFED) prepared an estimate of potential residues in drinking water [G. Orrick, Tier I Drinking Water Exposure Assessment for Acetamiprid on Cucurbit, Stone Fruit and Tree Nut Crop Groups, 6/21/05, D303582]. EFED stated in a June 10, 2009 memorandum (D364248, D. L ieu) that this assessment was still valid and should be used to assess the proposed uses on red clover (grown for seed), grape , and tomato (greenhouses). Estimated drinking water concentrations for acetamiprid in surface water were gen erated using the FIRST ( F QPA I ndex R eservoir S

creening T

ool, v. 1.0) M odel. The results of the model reflect potential residues in a small drinking water reservoir surrounded b y a runoff

- prone watershed, assuming maximum pesticide application rates and no buffer between the reservoir and treated fields. Acetamiprid residues in ground water sources ofAcetamiprid Dietary Exposure Assessment DP No.: 3 72890

PC Code: 099050



### Page 7 of 28 drinking water were estimated using the screening regression model SCI

- GROW ( S creening Concentration I

n Gro und W

ater, v. 2.3). The SCI

- GROW residue estimate is based on environmental fate properties of the pesticide, maximum application rates, and existing data from small

- scale prospective ground

- water monitoring studies in vulnerable sites. For surface water, the maximum application rate for the existing us e of acetamiprid on citrus was used to provide model estimates of drinking water concentrations; for ground water, the proposed use on tree nut crops was used. However, since modeled surface water residues were considerabl y higher than ground water residu es, only the surface water residues were used quantitatively

in the dietary

(food + water) assessment

.

Table 4 . Tier I Analysis 1
- in
- 10
- year EDWCs in surface water and ground water for acetamiprid. Drinking Water Source Maximum Use Pattern Exposure EDW C Surface water Citrus fruit Peak 20.1 ppb Annual average 4.9 ppb Ground water Tree nut Peak & annual average 1.6 ppt

For the acute assessment, an estimated drinking water concentration of 20.1 ppb was entered into the DEEMTM

- FCID M odel for “water, direct, all sources” and “water, indirect, all sources.” For the chronic assessment, the value of 4.9 ppb was used. The ground water estimate of 1.6 ppt was much lower than surface water residues; therefore, dietary exposure and risk calculated using surface water residues are considered protective of potential exposure through ground water.
III. Exposure Model and Consumption Information Acetamiprid acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM

FCIDTM,Version 2.03 which incorporates consumption data from USDA’s Continuing Survey s of Food Intakes by

Individuals (CSFII), 1994

- 1996 and 1998. The 1994

- 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g. apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analy sis of the 1994

- 96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49 , females 13

- 49, and adultsAcetamiprid Dietary Exposure Assessment DP No.: 3 72890

PC Code: 099050



### Page 8 of 28 50+ years old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For acute exposure assessments, individual one

- day food consumption data are used on an individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a p er - capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of anal ysis. However, for tiers 1 and 2, an y significant diffe rences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. IV. Toxicological Information Doses and endpoints selected for acute and chronic dietary exposure and risk assessments are summarized as shown i n Table 5 , below. Details regarding hazard characterization and endpoint selection can be found in the risk assessment associated with the proposed uses [ D369 474 , Dennis McNeilly , Dec 1 , 2009 ].

Table 5 . Acetamiprid Toxicological Doses/Endpoints for Diet ary Risk Assessment. Exposure Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD, PAD, Level of Concern Study and Toxicological Effects Ac ute Dietary [All Populations] NOAEL= 10.0

mg/kg/day UF A= 1 0 x

UF H = 1 0 x FQPA SF= 1x Ac ute RfD = 0. 10

mg/kg/day
aPAD = 0.10 mg/kg/day Developmental Neurotox ., Rat

LOAEL = 45 .0 mg/kg/day based on decreased startle response on PND20/60 in males Co Critical study

- Ac ute N eurotox ., Rat LOAEL = 30 mg /k g/d ay based on reduc ed locomotor activity in males.Acetamiprid Dietary Exposure Assessment DP No.: 3 72890

PC Code: 099050



### Page 9 of 28 Table 5 . Acetamiprid Toxicological Doses/Endpoints for Diet ary Risk Assessment. Exposure Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD, PAD, Level of Concern Study and Toxicological Effects Chronic Dietary [all populations] NOAEL = 7.1

mg/kg/day UF A= 1 0 x

UF H = 1 0 x FQPA SF= 1x Chronic RfD =

0.071 mg/kg/day
cPAD = 0.071 mg/kg/day Chronic/oncogenicity , Ra t

LOAEL= 17.5 m g/k g/d ay based on reduced body weight and body weight gain ( ♀) and hepatocel lular vacuolation ( ♂). Cancer (All routes) Not likely to be a human carcinogen.



### V. Results/Discussion As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. For both the acute and chronic anal y ses, the estimated dietary exposures are below HED’s level of concern for all population subgroups; the most highly exposed population subgroup for both acute and chronic durations is children 1

- 2 years old. Acute dietary

exposure estimates at the 99.9 th 

### percentile are below HED’s level of concern for the general US population and all other population subgroups. For the US population, the estimated exposure of 0.0 2 4 mg/kg/day corresponds to 2 4 % aPAD; for children 1

- 2 years old, the estimated exposure of 0 .0 4 3 mg/kg/day corresponds to an acute dietary risk of 4 3 % aPAD. Chronic dietary

exposure to acetamiprid is below HED’s level of concern for the US population and all other population subgroups. For the general US population, an estimated exposure of 0.0 0 2 8 mg/kg/day

corresponds to 4 % of the chronic population adjusted dose (cPAD); children 1

- 2 years old were the highest exposed population subgroup, with an estimate of 0.0 1 0 mg/kg/day , or 1 5 % cPAD. Risks for all population subgroups are less than 100 % cPAD, and are not of concern. The results of the acute and chronic analy ses are shown in Tables 6 and 7

.

Table 6 . Results of Acetamiprid Acute Dietary (Food + Water) Exposure Analysis. Population Subgroup aPAD (m g/kg/day) 95 th Percentile 99 th Percentil e 99.9 th Percentile

Exposure (m g/kg/day) % aPAD Exposure (m g/kg/day) % aPAD Exposure (m g/kg/day) % aPAD General U.S. Population 0.10 0.00 6 7 52 6. 8 0.01 23 67 1 2 0.0 2 37 68 2 4 All Infants (< 1 year old) 0.10 0.01 20 43 1 2 0.0 2007 5 20 0.03 1 2 27 3 1 Children 1

- 2 years old 0.10 0.01 6 7 70 1 7 0.02 53 37 2 5 0.04 2 928 4 3 Children 3

- 5 years old 0.10 0.01 22 77 1 2 0.0 202 79 20 0.0 342 82 3 4 Children 6

- 12 years old 0.10 0.00 7 509 7.5 0.0 1 32 99 1 3 0.0 24 123 24Acetamiprid Dietary Exposure Assessment DP No.: 3 72890

PC Code: 099050



### Page 10 of 28

Table 6 . Results of Acetamiprid Acute Dietary (Food + Water) Exposure Analysis. Population Subgroup aPAD (m g/kg/day) 95 th Percentile 99 th Percentil e 99.9 th Percentile

Exposure (m g/kg/day) % aPAD Exposure (m g/kg/day) % aPAD Exposure (m g/kg/day) % aPAD Youth 13

- 19 years old 0.10 0.00 4 68 6 4. 7 0.00 7 8 10 7. 8 0.01 7 6 82 18 Adult s 20

- 49 years old 0.10 0.00 4 600 4. 6 0.00 7 6 85 7. 7 0.01 5 543 1 6 Adults 50+ years old 0.10 0.00 4 67 1 4. 7 0.00 7 8 22 7. 8 0.0 1 32 91 1 3 Females 13

- 49 years old 0.10 0.00 4 6 3 2 4

. 6 0.00 7 27 7 7 .3 0.0 1 31 33 1 3

Table 7 . Summary of Dietary (Food + Water) Exposure and Ri sk for Acetamiprid
Population Subgroup Ac ute Dietary (99.9 th Percentile) Chronic Dietary Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD General U.S. Population 0.023768 24 0.002835 4.0 All Infants (< 1 year old) 0.031227 31 0. 005206 7.3 Children 1
- 2 years old 0.042928 43 0.010358 15 Children 3

- 5 years old 0.034282 34 0.007296 10 Children 6

- 12 years old 0.024123 24 0.004055 5.7 Youth 13

- 19 years old 0.017682 18 0.002170 3.1 Adults 20

- 49 years old 0.015543 16 0.002031 2.9 A dults 50+ years old 0.013291 13 0.002130 3.0 Females 13

- 49 years old 0.013133 13 0.002057 2.9



### VI

. Characterization of Inputs/Outputs The acute dietary

exposure assessment for acetamiprid is somewhat refined, since field trial residue distributions we re used in the probabilistic assessment, and percent crop treated information was incorporated for some commodities. In addition, empirical processing factors for various processed commodities, especiall y juices, provided an additional measure of refineme nt. However, the assessment is still somewhat conservative because tolerance

- level residues were used for proposed uses and some of the existing uses, as well as livestock commodities. Additional refinements could be made to the assessment with the use o f additional field trial residue data. Even though the acute probabilistic assessment has not been completely refined, acute dietary

exposure and risk estimates for acetamiprid are below HED’s level of concern of 100 % aPAD. The chronic dietary

exposure assessment is unrefined, with the exception of the use of %CT data cited in Table 3 . For all commodities, tolerance level residues were used, and DEEM 7.8 1 defaultAcetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 11 of 28 processing factors were applie d . Further refinements are possible in the future, including the use of average field trial residues, empirical processing factors and additional %CT refinements.
VII. Conclusions Acute and chronic dietary (food + water) risks for acetamiprid are below HED’s level of concern for dietary

exposure and risk. Childr en 1

- 2 years old are the most highl y exposed population subgroup, with risks of 4 3 % aPAD for acute and 1 5 % cPAD for chronic . Risks were lower for all other population subgroups, including the general US population. The acute and chronic dietary exposure assessments support the new uses proposed for acetamiprid.
VIII. List of Attachments Attachment 1. Acetamiprid Residue Distribution Files Attachment 2

. Acetamiprid Screening Level Usage Anal ys is (SLUA) Attachment 4. Acute Residue Input Files Attachment 5 Summary

of Acute Results Attachment 6. Chronic Residue Input File Attachment 7. Summary

of Chronic ResultsAcetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 12 of 28 Attachment 1. Acetamiprid Residue Distribution Files

Acetamiprid/Apple TOTALZ= 149 Est. Max. %CT = 30 MRID No. 44988626 0.15, 0.16, 0.59, 0.59 0.25 0.29, 0.11, 0.16, 0.12, 0.12 0.24, 0.32, 0.17, 0.18, 0.20 0.23, 0.13, 0.14, 0.21, 0.28 0.09, 0.15, 0.24, 0.28, 0.22 0.39, 0.17, 0.20, 0.45, 0.64 0.22, 0.28, 0.23, 0.23, 0.21 0.25, 0.30, 0.30, 0.25, 0.26 0.26, 0.36, 0.14, 0.16, 0.23 0.27, 0.08, 0.10, 0.30, 0.34 0.25, 0.29, 0.08 0.10, 0.10 0.23, 0.18, 0.21, 0.61, 0.71 0.34, 0.35, 0.21, 0.24 Acetamiprid/Broccoli Estimated max %CT = 1 5 TOTALZ= 1 3 0 MRID No. 44988631 0.02, 0.04, 0.04, 0.05, 0.01 0.01, 0.005, 0.02, 0.01, 0.02 0.005, 0.01, 0.07, 0.11, 0.18 0.25, 0. 02, 0.097, 0.10, 0.080 0.092, 0.081, 0.10 Acetamiprid/Cabbage w/out wrapper leaves, 10 %CT TOTALZ= 1 80 MRID No. 44988631 0.005, 0.02, 0.005, 0.01, 0.005 0.005, 0.005, 0.005, 0.03, 0.03 0.005, 0.005, 0.01, 0.02, 0.02 0.02, 0.05, 0.05, 0.03, 0.03 Acetamiprid/Celery Estimated Max. %CT = 45 TOTALZ= 20 MRID No. 44988603 0.775, 0.780, 0.167, 0.182 0.396, 0.426, 0.287, 0.352 0.250, 0.290, 0.255, 0.281 0.499, 0.517, 0.068, 0.084

Acetamiprid/Cucurbit Assume 100%CT MRID No. 46265701 0.024, 0.038, 0.015, 0.026 0.024, 0.030, 0.038, 0.045 0.082, 0.091, 0.017, 0.019 0.070, 0.090, 0.035, 0.076 0.011, 0.026, 0.011, 0.021 0.035, 0.037, 0.065, 0.142, 0.091, 0.094, 0.075, 0.136 0.053, 0.068, 0.166, 0.221 0.004, 0.075 Acetamiprid/Grape Assume 10 0% CT TOTALZ=0 MRID No. 47716902 0.05, 0.05 , 0.03, 0.03, 0.01, 0.01, 0.08 , 0.08, 0.17, 0.15, 0.08, 0.09 , 0.08, 0.08, 0.2, 0.21, 0.24 , 0.25, 0.1, 0.11, 0.06, 0.06 , 0.22, 0.22, 0.04, 0.04, 0.07 , 0.06, 0.04, 0.03, 0.15, 0.15 , 0.24, 0.22, 0.13, 0.13 Acetamiprid/Head Lettuce MRID No. 44988603 Estimated Max. %CT = 2 0% TOTALZ= 7 2 0.155, 0.184, 0.253, 0.294, 0.017, 0.018, 0.047, 0.057 0.005, 0.005, 0.060, 0.061 0.014, 0.014, 0.010, 0.010 0.074, 0.14 Acetamiprid/Leaf Lettuce Estimated Maximum %CT= 2 0 TOTALZ=80 MRID No. 44988603 0.716, 1.02, 0.108, 0 .123 0.565, 0.646, 0.265, 0.330 0.374, 0.449, 0.848, 1.07 0.098, 0.114, 0.435, 0.479 0.12, 0.18, 0.074, 0.14

Acetamiprid/Orange TOTALZ= 12 35 Est. max %CT=5 MRID No. 4498611 0.14, 0.15, 0.11, 0.12, 0.09 0.13, 0.19, 0.29, 0.18, 0.21 0.29, 0.097, 0.11, 0.15, 0.21 0.20, 0.20, 0.058, 0.084, 0.088 0.15, 0.11, 0.15, 0.094, 0.12 0.19, 0.20, 0.19, 0.21, 0.26 0.29, 0.21, 0.23, 0.025, 0.025 0.13, 0.14, 0.081, 0.12, 0.14 0.14, 0.083, 0.12, 0.025, 0.025, 0.025, 0.025, 0.025, 0.098 0.23, 0.27, 0.12, 0.14, 0.079 0.096, 0. 087, 0.12, 0.12, 0.16 0.31, 0.37, 0.16, 0.31, 0.26 0.39 Acetamiprid/Peach Assume 2.5 %CT TOTALZ= 1 0 14 MRID No. 46265702 0.294, 0.344, 0.311, 0.565 0.184, 0.225, 0.163, 0.188 0.182, 0.223, 0.117, 0.138 0.153, 0.166, 0.283, 0.387 0.205, 0.233, 0.192, 0.240 0.2 11, 0.242, 0.0927, 0.133 0.186, 0.199 Acetamiprid/Pear TOTALZ= 42 Est. Max. %CT = 60 MRID No. 44988626 0.15, 0.16, 0.59, 0.59 0.25 0.29, 0.11, 0.16, 0.12, 0.12 0.24, 0.32, 0.17, 0.18, 0.20 0.23, 0.13, 0.14, 0.21, 0.28 0.09, 0.15, 0.24, 0.28, 0.22 0.39, 0.17 , 0.20, 0.45, 0.64 0.22, 0.28, 0.23, 0.23, 0.21 0.25, 0.30, 0.30, 0.25, 0.26 0.26, 0.36, 0.14, 0.16, 0.23 0.27, 0.08, 0.10, 0.30, 0.34 0.25, 0.29, 0.08 0.10, 0.10 0.23, 0.18, 0.21, 0.61, 0.71 0.34, 0.35, 0.21, 0.24 Acetamiprid/Peppers Estimated Max. %CT = 5 TOTALZ= 5 70 MRID No. 44988616 0.005, 0.005, 0.01, 0.02, 0.01 0.01, 0.03, 0.05, 0.03, 0.04 0.01, 0.01, 0.02, 0.03, 0.02 0.02, 0.08, 0.09, 0.03, 0.03 0.06, 0.07, 0.04, 0.07, 0.05 0.06, 0.12, 0.16, 0.08, 0.08Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 13 of 28 Acetamiprid/Plum Assume 100%CT TOTALZ=0 MRID No. 46265702 0.108, 0.116, 0.0648, 0.119 0.0139, 0.0238, 0.0103, 0.0154 0.0515, 0.0624, 0.0401, 0.0429 0.0305, 0.0458, 0.0258, 0.0392 Acetamiprid/Spinach Assume 1 5 %CT TOTALZ= 12 5 MRID No. 44988603 0.034, 0.037, 0.184, 0.238 0.026, 0.036, 1.06, 1.20, 2.46 2.58, 0.516, 0.588, 1.95, 2.22 0.463, 0.466, 0.15, 0.23, 0.18 0.18, 0.19, 0.22 Acetamiprid/Tomatoes Assume %CT= 10 0 TOTALZ= 0 MRID s 44988616 /47716903 0.01, 0.01, 0.005, 0.005, 0.005, 0.005, 0.01, 0.04, 0.08, 0.11 0.005, 0.01, 0.07, 0.08, 0.06 0.11, 0.02, 0.03, 0. 02, 0.04 0.02, 0.02, 0.03, 0.03, 0.05 0.07, 0.03, 0.05, 0.06, 0.06 0.03, 0.05, 0.02, 0.02, 0.005 0.005 , 0.047, 0.052, 0.005 0.005, 0.026, 0.028

Summary of Residue Distribution Files (RDF) listed in C: \ Documents and Settings \ Dmcneill \ My Documents \ Acet amiprid \ PRIAacetamiprid_acuteAR .r98
RDF File N residues N residues N Zeros # Name w freq's w/o freq's

---- ------------ ---------- ---------- ------- 1 orange.RDF 0 65 1 2 97 2 Apple.RDF 0 64 149 3 spinach.rdf 0 22 124 4 cabbage.RDF 0 20 1 80 5 peach.RDF 0 26 1114 6 Plum.RDF 0 16 0 7 Pear.RDF 0 64 43 8 Broccoli.RDF 0 23 130 9 Celery.RDF 0 16 20 10 HeadLettuce.RDF 0 18 72 11 LeafLettuce.RD F 0 20 80 12 cucurbit.RDF 0 34 0 13 Grapes.RDF 0 3 6 0 14 Peppers.RDF 0 30 570 15 Tomatoes.RDF 0 42 0Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 14 of 28 Attachment 2

. Acetamiprid Screening Level Usage Anal ys is (SLUA)Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 15 of 28Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 16 of 28 Attachment 3

. DEEM

- FCIDTM Acute Residue Input File
U.S. Environmental Protection Agency Ver. 2.02 DEEM

- FCID Acute analysis for ACETAMIPRID Residue file name: C: \ Documents and Settings \ dmcneill \ My Documents \ Actemidprid \ PRIAacetamiprid_a cuteAR_2010.R98 Analysis Date 01

- 14

- 2010 Residue file dated: 01

- 14

- 2010/06:49:51/8 Reference dose: aRfD = 0.1 mg/kg bw/day NOEL = 10 mg/kg bw/day Comment: Acute/Chronic

- UFs = 100

-------------------------------------------------------------- ------------------ RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ ----------- ----------- ---------- 1 6 orange.RDF 2 6 Appl e.RDF 3 6 spinach.rdf 4 6 cabbage.RDF 5 6 peach.RDF 6 6 Plum.RDF 7 6 Pear.RDF 8 6 Broccoli.RDF 9 6 Celery.RDF 10 6 HeadLettuce.RDF 11 6 LeafLettuce.RDF 12 6 cucurbit.RDF 13 6 Grapes.R DF 14 6 Peppers.RDF 15 6 Tomatoes.RDF EPA Crop Food Name Def Res Adj.Factors RDL Comment Code Grp (ppm) #1 #2 Pntr

-------- ---- --------------------------- ---- ---------- ------ ------ --- ------- 14000030 14 Almond 0.100000 1.000 1.000 14000031 14 Almond

- babyfood 0.100000 1.000 1.000 14000040 14 Almond, oil 0.10 0000 1.000 1.000 14000041 14 Almond, oil

- babyfood 0.100000 1.000 1.000 04010050 4A Amaranth, leafy 3.000000 1.000 1.000 11000070 11 Apple, fruit with peel 1.000000 1.000 1.000 2 11000080 11 Apple, peeled fruit 1.000000 1.000 1.000 2 11000081 11 Apple, peeled fruit

- babyfood 1.000000 1.000 1.000 2 11000090 11 Apple, dried 1.000000 8.000 1.000 2 11000091 11 Apple, dried

- babyfood 1.000000 8.000 1.000 2 11000100 11 Apple, juice 1.000000 0.880 1.000 2 11000101 11 Apple, juice

- babyfood 1.000000 0.880 1.000 2 11000110 11 Apple, sauce 1.000000 1.000 1.000 2 11000111 11 Apple, sauce

- babyfood 1.000000 1.000 1.000 2 12000120 12 Apricot 1.200000 1.000 1.000 6 12000121 12 Apricot

- babyfood 1 .200000 1.000 1.000 6 12000130 12 Apricot, dried 1.200000 2.900 1.000 6 12000140 12 Apricot, juice 1.200000 1.000 1.000 6 12000141 12 Apricot, juice

- babyfood 1.200000 1.000 1. 000 6 01030150 1CD Arrowroot, flour 0.010000 1.000 1.000 01030151 1CD Arrowroot, flour

- babyfood 0.010000 1.000 1.000 01030170 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 04010180 4A Arugula 3.000000 1.000 1.000 09020210 9B Balsam pear 0.500000 1.000 1.000 06020310 6B Bean, broad, succulent 0.400000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.400000 1.000 1.000 06020370 6B Bean, lima, succulent 0.400000 1.000 1.000 06010430 6A Bean, snap, succulent 0.600000 1.000 1.000 06010431 6A Bean, snap, succulent

- babyfood 0.600000 1.000 1.000 21000440 M Beef, meat 0.100000 1.000 1.000 21000441 M Beef, meat

- babyfood 0.100000 1.000 1.000 21000450 M Beef, meat, dried 0.100000 1.920 1.000 21000460 M Beef, meat byproducts 0.200000 1.000 1.000 21000461 M Beef, meat byproducts

- babyfood 0.200000 1.000 1.000Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 17 of 28 21000470 M Beef, fat 0.100000 1.000 1.000 210004 71 M Beef,fat

- babyfood 0.100000 1.000 1.000 21000480 M Beef, kidney 0.200000 1.000 1.000 21000490 M Beef, liver 0.200000 1.000 1.000 21000491 M Beef, liver

- babyfood 0.200000 1.000 1.000 13010550 13A Blackberry 1.600000 1.000 1.000 13010560 13A Blackberry, juice 1.600000 1.000 1.000 13010561 13A Blackberry, juice

- babyfood 1.600000 1.000 1.000 13020570 13B Blueberry 1.600000 1.000 1.000 13020571 13B Blueberry

- babyfood 1.600000 1.000 1.000 13010580 13A Boysenberry 1.600000 1.0 00 1.000 14000590 14 Brazil nut 0.100000 1.000 1.000 05010610 5A Broccoli 1.200000 1.000 1.000 8 05010611 5A Broccoli

- babyfood 1.200000 1.000 1.000 8 050 10620 5A Broccoli, Chinese 1.200000 1.000 1.000 8 05020630 5B Broccoli raab 1.200000 1.000 1.000 05010640 5A Brussels sprouts 1.200000 1.000 1.000 14000680 14 Butternu t 0.100000 1.000 1.000 05010690 5A Cabbage 1.200000 1.000 1.000 4 05020700 5B Cabbage, Chinese, bok choy 1.200000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 09010750 9A Cantaloupe 0.500000 1.000 1.000 04020760 4B Cardoon 3.000000 1.000 1.000 09010800 9A Casaba 0.500000 1.000 1.000 14000810 14 Cashew 0.100000 1.000 1.000 01030820 1CD Cassava 0.010000 1.000 1.000 01030821 1CD Cassava

- babyfood 0.010000 1.000 1.000 05010830 5A Cauliflower 1.200000 1.000 1.000 04020850 4B Celery 3.000000 1.000 1.000 9 04020851 4B Celer y - babyfood 3.000000 1.000 1.000 9 04020860 4B Celery, juice 3.000000 1.000 1.000 9 04020870 4B Celtuce 3.000000 1.000 1.000 09020880 9B Chayote, fruit 0.500000 1.000 1.000 12000900 12 Cherry 1.200000 1.000 1.000 12000901 12 Cherry

- babyfood 1.200000 1.000 1.000 12000910 12 Cherry, juice 1.200000 1.500 1.000 12000911 12 Cherry, juice

- babyfood 1.200000 1.500 1.000 14000920 14 Chestnut 0.100000 1.000 1.000 40000930 P Chicken, meat 0.010000 1.000 1.000 40000931 P Chicken, meat

- babyfood 0.010000 1.000 1.000 40000940 P Chicken, liver 0.050000 1.000 1.000 40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 40000951 P Ch icken, meat byproducts

- babyfoo 0.050000 1.000 1.000 40000960 P Chicken, fat 0.010000 1.000 1.000 40000961 P Chicken, fat

- babyfood 0.010000 1.000 1.000 40000970 P Chicken, skin 0.010000 1.000 1.000 40000971 P Chicken, skin

- babyfood 0.010000 1.000 1.000 09021020 9B Chinese waxgourd 0.500000 1.000 1.000 19011030 19A Chive 4.500 000 1.000 1.000 04011040 4A Chrysanthemum, garland 3.000000 1.000 1.000 10001060 10 Citrus citron 0.500000 1.000 1.000 10001070 10 Citrus hybrids 0.500000 1.000 1.000 10001080 10 Citrus, oil 0.500000 1.000 1.000 05021170 5B Collards 1.200000 1.000 1.000 95001280 O Cottonseed, oil 0.600000 1.000 1.000 95001281 O Cottonseed, oil

- babyfood 0.600000 1.000 1.000 11001290 11 Crabapple 1.000000 1.000 1.000 95001300 O Cranberry 0.600000 1.000 1.000 95001301 O Cranberry

- babyfood 0.600000 1.000 1.000 95001310 O Cranberry, dried 0.600000 1.000 1.000 95001320 O Cranberry, juice 0.600000 1.100 1.000 95001321 O Cranberry, juice

- babyfood 0. 600000 1.100 1.000 04011330 4A Cress, garden 3.000000 1.000 1.000 04011340 4A Cress, upland 3.000000 1.000 1.000 09021350 9B Cucumber 0.500000 1.000 1.0 00 12 13021360 13B Currant 1.600000 1.000 1.000 13021370 13B Currant, dried 1.600000 1.000 1.000Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 18 of 28 04011380 4A Dandelion, leaves 3.000000 1.000 1.000 01031390 1 CD Dasheen, corm 0.010000 1.000 1.000 13011420 13A Dewberry 1.600000 1.000 1.000 70001450 P Egg, whole 0.010000 1.000 1.000 70001451 P Egg, whole

- baby food 0.010000 1.000 1.000 70001460 P Egg, white 0.010000 1.000 1.000 70001461 P Egg, white (solids)

- babyfood 0.010000 1.000 1.000 70001470 P Egg, yolk 0.010000 1.000 1.000 70001471 P Egg, yolk

- babyfood 0.010000 1.000 1.000 08001480 8 Eggplant 0.200000 1.000 1.000 13021490 13B Elderberry 1.600000 1.000 1.000 04011500 4A Endive 3.000000 1.000 1.000 04021520 4B Fennel, Florence 3.000000 1.000 1.000 14001550 14 Filbert 0.100000 1.000 1.000 1400156 0 14 Filbert, oil 0.100000 1.000 1.000 03001640 3 Garlic 0.020000 1.000 1.000 03001650 3 Garlic, dried 0.020000 1.000 1.000 03001651 3 Garlic, drie d

- babyfood 0.020000 1.000 1.000 01031660 1CD Ginger 0.010000 1.000 1.000 01031661 1CD Ginger

- babyfood 0.010000 1.000 1.000 01031670 1CD Ginger, dried 0.010000 1.000 1.000 23001690 M Goat, meat 0.100000 1.000 1.000 23001700 M Goat, meat byproducts 0.200000 1.000 1.000 23001710 M Goat, fat 0.100000 1.00 0 1.000 23001720 M Goat, kidney 0.200000 1.000 1.000 23001730 M Goat, liver 0.200000 1.000 1.000 13021740 13B Gooseberry 1.600000 1.000 1.000 9500 1750 O Grape 0.350000 1.000 1.000 13 95001760 O Grape, juice 0.350000 1.000 1.000 13 95001761 O Grape, juice

- babyfood 0.350000 1.000 1.000 13 95001770 O Grape, le aves 0.350000 1.000 1.000 13 95001780 O Grape, raisin 0.350000 0.900 1.000 13 95001790 O Grape, wine and sherry 0.350000 1.000 1.000 13 10001800 10 Grapefruit 0.500000 1.000 1.000 1 10001810 10 Grapefruit, juice 0.500000 0.160 1.000 1 14001850 14 Hickory nut 0.100000 1.000 1.000 09011870 9A Honeydew melon 0.500000 1 .000 1.000 24001890 M Horse, meat 0.100000 1.000 1.000 13021910 13B Huckleberry 1.600000 1.000 1.000 05021940 5B Kale 1.200000 1.000 1.000 9 5001950 O Kiwifruit 0.350000 1.000 1.000 05011960 5A Kohlrabi 1.200000 1.000 1.000 10001970 10 Kumquat 0.500000 1.000 1.000 03001980 3 Leek 4.500000 1.000 1.000 10001990 10 Lemon 0.500000 1.000 1.000 10002000 10 Lemon, juice 0.500000 2.000 1.000 10002001 10 Lemon, juice

- babyfood 0.500000 2.000 1.000 10002010 10 Lemon, peel 0.500000 1.000 1.000 04012040 4A Lettuce, head 3.000000 1.000 1.000 10 04012050 4A Lettuce, leaf 3.000000 1.000 1.000 11 10002060 10 Lime 0.500000 1.000 1.000 10002070 10 Lime, juice 0.500000 2.000 1.000 10002071 10 Lime, juice

- babyfood 0.500000 2.000 1.000 13012080 13A Loganberry 1.600000 1.000 1.000 11002100 11 Loquat 1.000000 1.000 1.000 14002130 14 Macadamia nut 0.100000 1.000 1.000 28002210 M Mea t, game 0.100000 1.000 1.000 27002220 D Milk, fat 0.100000 1.000 1.000 27002221 D Milk, fat

- baby food/infant for 0.100000 1.000 1.000 27012230 D Milk, nonfat solids 0.100000 1.000 1.000 27012231 D Milk, nonfat solids

- baby food/in 0.100000 1.000 1.000 27022240 D Milk, water 0.100000 1.000 1.000 27022241 D Milk, water

- babyfood/infant form 0.1000 00 1.000 1.000 27032251 D Milk, sugar (lactose)

- baby food/ 0.100000 1.000 1.000 05022290 5B Mustard greens 1.200000 1.000 1.000 12002300 12 Nectarine 1.200000 1.000 1.000 5 08002340 8 Okra 0.200000 1.000 1.000 03002370 3 Onion, dry bulb 0.020000 1.000 1.000Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 19 of 28 03002371 3 Onion, dry bulb

- babyfood 0.020000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.020000 9.000 1.000 03002381 3 Onion, dry bulb, dried

- babyfood 0.020000 9.000 1.000 03002390 3 Onion, green 4.500000 1.000 1.000 10002400 10 Orange 0.500000 1.000 1.000 1 10002410 10 Orange, juice 0.500000 0.160 1.000 1 10002411 10 Orange, juice

- babyfood 0.500000 0.160 1.000 1 10002420 10 Orange, peel 0.5 00000 1.000 1.000 1 04012480 4A Parsley, leaves 3.000000 1.000 1.000 06022550 6B Pea, succulent 0.400000 1.000 1.000 06022551 6B Pea, succulent

- babyfood 0.400000 1.000 1.00 0 06012570 6A Pea, edible podded, succulent 0.600000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.400000 1.000 1.000 12002600 12 Peach 1.200000 1.000 1.000 5 12002601 12 Peach

- babyfood 1.200000 1.000 1.000 5 12002610 12 Peach, dried 1.200000 2.900 1.000 5 12002611 12 Peach, dried

- babyfood 1.200000 2.900 1.000 5 12002620 12 Peach, juice 1.200000 1.000 1.000 5 12002621 12 Peach, juice

- babyfood 1.200000 1.000 1.000 5 11002660 11 Pear 1.000000 1.000 1.000 7 11002661 11 Pear

- babyfood 1.000000 1.000 1.000 7 11002670 11 Pear, dried 1.000000 6.250 1.000 7 11002680 11 Pear, juice 1.000000 0.880 1.000 7 11002681 11 Pear, juice

- babyfood 1.000000 0.880 1 .000 7 14002690 14 Pecan 0.100000 1.000 1.000 08002700 8 Pepper, bell 0.200000 1.000 1.000 14 08002701 8 Pepper, bell

- babyfood 0.200000 1.000 1.000 14 08002710 8 Pepper, bell, dried 0.200000 1.000 1.000 14 08002711 8 Pepper, bell, dried

- babyfood 0.200000 1.000 1.000 14 08002720 8 Pepper, nonbell 0.200000 1.000 1.000 14 08002721 8 Pepper, nonbe ll

- babyfood 0.200000 1.000 1.000 14 08002730 8 Pepper, nonbell, dried 0.200000 1.000 1.000 14 14002820 14 Pistachio 0.100000 1.000 1.000 12002850 12 Plum 1.200000 1.000 1.000 6 12002851 12 Plum

- babyfood 1.200000 1.000 1.000 6 12002860 12 Plum, prune, fresh 0.200000 1.000 1.000 6 12002861 12 Plum, prune, fresh

- babyfood 0.200000 1.000 1.000 6 12002870 12 Plum, prune, dried 0.400000 2.900 1.000 6 12002871 12 Plum, prune, dried

- babyfood 0.400000 2.900 1.000 6 12002880 12 Plum, prune, juice 0.200000 1.400 1.000 6 12002 881 12 Plum, prune, juice

- babyfood 0.200000 1.400 1.000 6 25002900 M Pork, meat 0.100000 1.000 1.000 25002901 M Pork, meat

- babyfood 0.100000 1.000 1.000 25002910 M Pork, skin 0.100000 1.000 1.000 25002920 M Pork, meat byproducts 0.200000 1.000 1.000 25002921 M Pork, meat byproducts

- babyfood 0.200000 1.000 1.000 25002930 M Pork, fat 0.100000 1.000 1.000 25002931 M Pork, fat

- babyfood 0.100000 1.000 1.000 25002940 M Pork, kidney 0.200000 1.000 1.000 25002950 M Pork, liver 0.200000 1. 000 1.000 01032960 1C Potato, chips 0.010000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.010000 6.500 1.000 01032971 1C Potato, dry (granules/ flakes)

- b 0.010000 6.500 1.000 01 032980 1C Potato, flour 0.010000 6.500 1.000 01032981 1C Potato, flour

- babyfood 0.010000 6.500 1.000 01032990 1C Potato, tuber, w/peel 0.010000 1.000 1.000 01032991 1C Potato, tuber, w/peel

- babyfood 0.010000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 01033001 1C Potato, tuber, w/o peel

- babyfood 0.010000 1.000 1.000 60003010 P Poultry, other, meat 0.010000 1.000 1.000 60003020 P Poultry, other, liver 0.050000 1.000 1.000 60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 60003040 P Poultry, other, fat 0.010000 1.000 1.000 60003050 P Poultry, other, skin 0.010000 1.000 1.000 10003070 10 Pummelo 0.500000 1.000 1.000 09023080 9B Pumpkin 0.500000 1.000 1.000 09023090 9B Pumpkin, seed 0.500000 1.000 1.000 11003100 11 Quince 1.000000 1.000 1.000Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 20 of 28 29003120 M Rabbit, meat 0.100000 1.000 1.000 04013130 4A Radi cchio 3.000000 1.000 1.000 05023180 5B Rape greens 1.200000 1.000 1.000 20003190 20 Rapeseed, oil 0.010000 1.000 1.000 20003191 20 Rapeseed, oil

- babyfood 0.010000 1.000 1.000 13013200 13A Raspberry 1.600000 1.000 1.000 13013201 13A Raspberry

- babyfood 1.600000 1.000 1.000 13013210 13A Raspberry, juice 1.60000 0 1.000 1.000 13013211 13A Raspberry, juice

- babyfood 1.600000 1.000 1.000 04023220 4B Rhubarb 3.000000 1.000 1.000 03003380 3 Shallot 0.020000 1.000 1.000 26003390 M Sheep, meat 0.100000 1.000 1.000 26003391 M Sheep, meat

- babyfood 0.100000 1.000 1.000 26003400 M Sheep, meat byproducts 0.200000 1.000 1.000 26003410 M S heep, fat 0.100000 1.000 1.000 26003411 M Sheep, fat

- babyfood 0.100000 1.000 1.000 26003420 M Sheep, kidney 0.200000 1.000 1.000 26003430 M Sheep, liver 0.200000 1.000 1.000 19023540 19B Spices, other 0.010000 1.000 1.000 19023541 19B Spices, other

- babyfood 0.010000 1.000 1.000 04013550 4A Spinach 3.00 0000 1.000 1.000 3 04013551 4A Spinach

- babyfood 3.000000 1.000 1.000 3 09023560 9B Squash, summer 0.500000 1.000 1.000 12 09023561 9B Squash, summer

- babyfood 0.500000 1.000 1.000 12 09023570 9B Squash, winter 0.500000 1.000 1.000 12 09023571 9B Squash, winter

- babyfood 0.500000 1.000 1.000 12 95003590 O Strawberry 0.600000 1.000 1.000 95003591 O Strawberry

- babyfood 0.600000 1.000 1.000 95003600 O Strawberry, juice 0.600000 1.000 1.000 95003601 O Strawberry, juice

- babyfood 0.600000 1.000 1.000 01033660 1CD Sweet potato 0.010000 1.000 1.000 01033661 1CD Sweet potato

- babyfood 0.010000 1.000 1.000 04023670 4B Swiss chard 3.000000 1.000 1.000 10003690 10 Tangerine 0 .500000 1.000 1.000 10003700 10 Tangerine, juice 0.500000 2.300 1.000 01033710 1CD Tanier, corm 0.010000 1.000 1.000 95003720 O Tea, dried 50.000000 1.000 1. 000 95003730 O Tea, instant 50.000000 1.000 1.000 08003740 8 Tomatillo 0.200000 1.000 1.000 15 08003750 8 Tomato 0.200000 1.000 1.000 15 08003751 8 Tomato

- babyfood 0.200000 1.000 1.000 15 08003760 8 Tomato, paste 0.400000 3.000 1.000 15 08003761 8 Tomato, paste

- babyfood 0.400000 3.000 1.000 15 08003770 8 Tomato, puree 0.200000 1.400 1.000 15 08003771 8 Tomato, puree

- babyfood 0.200000 1.400 1.000 15 08003780 8 Tomato, dried 0.200000 14.300 1.000 15 08003781 8 Tomato, dried

- babyfood 0.200000 14.300 1.000 15 08003790 8 Tomato, juice 0.200000 1.500 1.000 15 50003820 P Turkey, meat 0.010000 1.000 1.000 50003821 P Turkey, meat

- babyfood 0.010000 1.000 1.000 50003830 P Turkey, liver 0.050000 1.000 1.000 50003831 P Turkey, liver

- babyfood 0.050000 1.000 1.000 50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 500038 41 P Turkey, meat byproducts

- babyfood 0.050000 1.000 1.000 50003850 P Turkey, fat 0.010000 1.000 1.000 50003851 P Turkey, fat

- babyfood 0.010000 1.000 1.000 50003860 P Turkey, ski n 0.010000 1.000 1.000 50003861 P Turkey, skin

- babyfood 0.010000 1.000 1.000 01033870 1CD Turmeric 0.010000 1.000 1.000 05023890 5B Turnip, greens 1.200000 1.000 1.000 14003910 14 Walnut 0.100000 1.000 1.000 86010000 O Water, direct, all sources 0.020100 1.000 1.000 86020000 O Water, indirect, all sources 0.020100 1.0 00 1.000 09013990 9A Watermelon 0.500000 1.000 1.000 09014000 9A Watermelon, juice 0.500000 1.000 1.000 01034060 1CD Yam, true 0.010000 1.000 1.000 010 34070 1CD Yam bean 0.010000 1.000 1.000Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 21 of 28Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 22 of 28 Attachment 4

. Summary

of DEEM

- FCIDTM Acute Results U.S. Environmental Protection Agency Ver. 2.02 DEEM

- FCID ACUTE Analysis for ACETAMIPRID (1994

- 98 data) Residue file: PRIAacetamiprid_acuteAR_2010.R98 Adjustment factor #2 NOT used. Analysis Date: 01

- 14

- 2010/06:56:20 Residue file dated: 01

- 14

- 2010/06:49:51/8 NOEL (Acute) = 10.000000 mg/kg body

- wt/day Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 10 Run Comment: "Acute/Chronic

- UFs = 100"

=============================================================================== Summary calculations (per capi ta):
95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- U. S. Population: 0.006752 6.75 1480 0.012367 12.37 808 0.023768 23.77 420 All infants: 0.012043 12.04 830 0.020075 20.08 498 0.031227 31.23 320 Children 1

- 2 yrs: 0.016770 16.77 596 0.025337 25.34 394 0.042928 42.93 232 Children 3

- 5 yrs: 0.012277 12.28 814 0.020279 20.28 493 0.034282 34.28 291 Children 6

- 12 yrs: 0.007509 7.51 1331 0.013299 13.30 751 0.024123 24.12 414 Yout h 13

- 19 yrs: 0.004686 4.69 2133 0.007810 7.81 1280 0.017682 17.68 565 Adults 20

- 49 yrs: 0.004600 4.60 2173 0.007685 7.69 1301 0.015543 15.54 643 Adults 50+ yrs: 0.004671 4.67 2140 0.007822 7.82 1278 0.013291 13.29 752 Females 13

- 49 yrs: 0.004632 4.63 2158 0.007277 7.28 1374 0.013133 13.13 761Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 23 of 28 Attachment 5. DEEM

- FCIDTM Chronic Residue Input File
U.S. Environmental Protection Agency Ver. 2.00 DEEM

- FCID Chronic analysis for ACETAMIPRID 1994

- 98 data Residue file: C: \ Documents and Settings \ dmcneill \ My Documents \ Actemidprid \ PRIADNTacetamipridCT_chronic.R98 Adjust. #2 used Analysis Date 01

- 12

- 2010 Residue file dated: 01

- 12

- 2010/08:15:02/8 Reference dose (RfD) = 0.071 mg/kg bw/day Comment:Acute/Chronic

- UFs = 100

---------------------------------------------------------------- ---------------- Food Crop Residue Adj.Factors Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 14000030 14 Almond 0.100000 1.000 1.000 14000031 14 Almond

- babyfood 0.100000 1.000 1.000 14000040 14 Almond, oil 0.100000 1.000 1.000 14000041 14 Almond, oil

- babyfood 0.100000 1.000 1.000 04010050 4A Amaranth, leafy 3.000000 1.000 1.000 11000070 11 Apple, fruit with peel 1.000000 1.000 0.200 11000080 11 Apple, peeled fruit 1.000000 1.000 0.200 11000081 11 Apple, peeled fruit

- babyfood 1.000000 1.000 0.200 11000090 11 Apple, dried 1.000 000 8.000 0.200 11000091 11 Apple, dried

- babyfood 1.000000 8.000 0.200 11000100 11 Apple, juice 1.000000 1.300 0.200 11000101 11 Apple, juice

- babyfood 1.000000 1.300 0.200 11000110 11 Apple, sauce 1.000000 1.000 0.200 11000111 11 Apple, sauce

- babyfood 1.000000 1.000 0.200 12000120 12 Apricot 1.200000 1.000 1.000 120001 21 12 Apricot

- babyfood 1.200000 1.000 1.000 12000130 12 Apricot, dried 1.200000 6.000 1.000 12000140 12 Apricot, juice 1.200000 1.000 1.000 12000141 12 Apricot, juice

- babyfood 1.200000 1.000 1.000 01030150 1CD Arrowroot, flour 0.010000 1.000 1.000 01030151 1CD Arrowroot, flour

- babyfood 0.010000 1.000 1.000 01030170 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 04010180 4A Arugula 3.000000 1.000 1.000 09020210 9B Balsam pear 0.500000 1.000 1.000 06020310 6B Bean, broad, succulent 0.400 000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.400000 1.000 1.000 06020370 6B Bean, lima, succulent 0.400000 1.000 1.000 06010430 6A Bean, snap, succulent 0.600000 1.000 1.000 06010431 6A Bean, snap, succulent

- babyfood 0.600000 1.000 1.000 21000440 M Beef, meat 0.100000 1.000 1.000 21000441 M Beef, meat

- babyfood 0.100000 1.000 1.000 210004 50 M Beef, meat, dried 0.100000 1.920 1.000 21000460 M Beef, meat byproducts 0.200000 1.000 1.000 21000461 M Beef, meat byproducts

- babyfood 0.200000 1.000 1.000 21000470 M Beef, fa t 0.100000 1.000 1.000 21000471 M Beef,fat

- babyfood 0.100000 1.000 1.000 21000480 M Beef, kidney 0.200000 1.000 1.000 21000490 M Beef, liver 0.200000 1.000 1.000 21000491 M Beef, liver

- babyfood 0.200000 1.000 1.000 13010550 13A Blackberry 1.600000 1.000 1.000 13010560 13A Blackberry, juice 1.600 000 1.000 1.000 13010561 13A Blackberry, juice

- babyfood 1.600000 1.000 1.000 13020570 13B Blueberry 1.600000 1.000 1.000 13020571 13B Blueberry

- babyfood 1.600000 1.000 1.000 13010580 13A Boysenberry 1.600000 1.000 1.000 14000590 14 Brazil nut 0.100000 1.000 1.000 05010610 5A Broccoli 1.200000 1.000 0.050 050106 11 5A Broccoli

- babyfood 1.200000 1.000 0.050 05010620 5A Broccoli, Chinese 1.200000 1.000 1.000 05020630 5B Broccoli raab 1.200000 1.000 1.000 05010640 5A Brussels sprouts 1.200000 1.000 1.000 14000680 14 Butternut 0.100000 1.000 1.000Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 24 of 28 05010690 5A Cabbage 1.200000 1.000 0.050 05020700 5B Cabbage, Chinese, bok ch oy 1.200000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 09010750 9A Cantaloupe 0.500 000 1.000 1.000 04020760 4B Cardoon 3.000000 1.000 1.000 09010800 9A Casaba 0.500000 1.000 1.000 14000810 14 Cashew 0.100000 1.000 1.000 01030820 1CD Cassava 0.010000 1.000 1.000 01030821 1CD Cassava

- babyfood 0.010000 1.000 1.000 05010830 5A Cauliflower 1.200000 1.000 0.100 040208 50 4B Celery 3.000000 1.000 0.250 04020851 4B Celery

- babyfood 3.000000 1.000 0.250 04020860 4B Celery, juice 3.000000 1.000 0.250 04020870 4B Celtuce 3.000000 1.000 1.000 09020880 9B Chayote, fruit 0.500000 1.000 1.000 12000900 12 Cherry 1.200000 1.000 1.000 12000901 12 Cherry

- babyfood 1.200000 1.000 1.000 12000910 12 Cherry, juice 1.200000 1.500 1.000 12000911 12 Cherry, juice

- babyfood 1.200000 1.500 1.000 14000920 14 Chestnut 0.100 000 1.000 1.000 40000930 P Chicken, meat 0.010000 1.000 1.000 40000931 P Chicken, meat

- babyfood 0.010000 1.000 1.000 40000940 P Chicken, liver 0.050000 1.000 1.000 40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 40000951 P Chicken, meat byproducts

- babyfoo 0.050000 1.000 1.000 40000960 P Chicken, fat 0.010000 1.000 1.000 400009 61 P Chicken, fat

- babyfood 0.010000 1.000 1.000 40000970 P Chicken, skin 0.010000 1.000 1.000 40000971 P Chicken, skin

- babyfood 0.010000 1.000 1.000 09021020 9B Chinese waxgourd 0.500000 1.000 1.000 19011030 19A Chive 4.500000 1.000 1.000 04011040 4A Chrysanthemum, garland 3.000000 1.000 1.000 10001060 10 Citrus citron 0.500000 1.000 1.000 10001070 10 Citrus hybrids 0.500000 1.000 1.000 10001080 10 Citrus, oil 0.500000 1.000 1.000 05021170 5B Collards 1.200 000 1.000 1.000 95001280 O Cottonseed, oil 0.600000 1.000 0.050 95001281 O Cottonseed, oil

- babyfood 0.600000 1.000 0.050 11001290 11 Crabapple 1.000000 1.000 1.000 95001300 O Cranberry 0.600000 1.000 1.000 95001301 O Cranberry

- babyfood 0.600000 1.000 1.000 95001310 O Cranberry, dried 0.600000 1.000 1.000 950013 20 O Cranberry, juice 0.600000 1.100 1.000 95001321 O Cranberry, juice

- babyfood 0.600000 1.100 1.000 04011330 4A Cress, garden 3.000000 1.000 1.000 04011340 4A Cress, u pland 3.000000 1.000 1.000 09021350 9B Cucumber 0.500000 1.000 1.000 13021360 13B Currant 1.600000 1.000 1.000 13021370 13B Currant, dried 1.600000 1.000 1.000 04011380 4A Dandelion, leaves 3.000000 1.000 1.000 01031390 1CD Dasheen, corm 0.010000 1.000 1.000 13011420 13A Dewberry 1.600 000 1.000 1.000 70001450 P Egg, whole 0.010000 1.000 1.000 70001451 P Egg, whole

- babyfood 0.010000 1.000 1.000 70001460 P Egg, white 0.010000 1.000 1.000 70001461 P Egg, white (solids)

- babyfood 0.010000 1.000 1.000 70001470 P Egg, yolk 0.010000 1.000 1.000 70001471 P Egg, yolk

- babyfood 0.010000 1.000 1.000 080014 80 8 Eggplant 0.200000 1.000 1.000 13021490 13B Elderberry 1.600000 1.000 1.000 04011500 4A Endive 3.000000 1.000 1.000 04021520 4B Fennel, Florence 3.000000 1.000 1.000 14001550 14 Filbert 0.100000 1.000 1.000 14001560 14 Filbert, oil 0.100000 1.000 1.000 03001640 3 Garlic 0.020000 1.000 1.000 03001650 3 Garlic, dried 0.020000 1.000 1.000 03001651 3 Garlic, dried

- babyfood 0.020000 1.000 1.000Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 25 of 28 01031660 1CD Ginger 0.010 000 1.000 1.000 01031661 1CD Ginger

- babyfood 0.010000 1.000 1.000 01031670 1CD Ginger, dried 0.010000 1.000 1.000 23001690 M Goat, meat 0.100000 1.000 1.000 23001700 M Goat, meat byproducts 0.200000 1.000 1.000 23001710 M Goat, fat 0.100000 1.000 1.000 23001720 M Goat, kidney 0.200000 1.000 1.000 230017 30 M Goat, liver 0.200000 1.000 1.000 13021740 13B Gooseberry 1.600000 1.000 1.000 95001750 O Grape 0.350000 1.000 1.000 95001760 O Grape, j uice 0.350000 1.000 1.000 95001761 O Grape, juice

- babyfood 0.350000 1.000 1.000 95001770 O Grape, leaves 0.350000 1.000 1.000 95001780 O Grape, raisin 0.350000 0.900 1.000 95001790 O Grape, wine and sherry 0.350000 1.000 1.000 10001800 10 Grapefruit 0.500000 1.000 0.025 10001810 10 Grapefruit, juice 0.500 000 2.100 0.025 14001850 14 Hickory nut 0.100000 1.000 1.000 09011870 9A Honeydew melon 0.500000 1.000 1.000 24001890 M Horse, meat 0.100000 1.000 1.000 13021910 13B Huckleberry 1.600000 1.000 1.000 05021940 5B Kale 1.200000 1.000 1.000 95001950 O Kiwifruit 0.350000 1.000 1.000 050119 60 5A Kohlrabi 1.200000 1.000 1.000 10001970 10 Kumquat 0.500000 1.000 1.000 10001990 10 Lemon 0.500000 1.000 0.050 10002000 10 Lemon, j uice 0.500000 2.000 0.050 10002001 10 Lemon, juice

- babyfood 0.500000 2.000 0.050 10002010 10 Lemon, peel 0.500000 1.000 0.050 04012040 4A Lettuce, head 3.000000 1.000 0.100 04012050 4A Lettuce, leaf 3.000000 1.000 0.100 10002060 10 Lime 0.500000 1.000 1.000 10002070 10 Lime, juice 0.500 000 2.000 1.000 10002071 10 Lime, juice

- babyfood 0.500000 2.000 1.000 13012080 13A Loganberry 1.600000 1.000 1.000 11002100 11 Loquat 1.000000 1.000 1.000 14002130 14 Macadamia nut 0.100000 1.000 1.000 28002210 M Meat, game 0.100000 1.000 1.000 27002220 D Milk, fat 0.100000 1.000 1.000 270022 21 D Milk, fat

- baby food/infant for 0.100000 1.000 1.000 27012230 D Milk, nonfat solids 0.100000 1.000 1.000 27012231 D Milk, nonfat solids

- baby food/in 0.100000 1.000 1.000 27022240 D Milk, wa ter 0.100000 1.000 1.000 27022241 D Milk, water

- babyfood/infant form 0.100000 1.000 1.000 27032251 D Milk, sugar (lactose)

- baby food/ 0.100000 1.000 1.000 05022290 5B Mustard greens 1.200000 1.000 1.000 12002300 12 Nectarine 1.200000 1.000 1.000 08002340 8 Okra 0.200000 1.000 1.000 03002370 3 Onion, dry bulb 0.020 000 1.000 1.000 03002371 3 Onion, dry bulb

- babyfood 0.020000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.020000 9.000 1.000 03002381 3 Onion, dry bulb, dried

- babyfood 0.020000 9.000 1.000 03002390 3 Onion, green 4.500000 1.000 1.000 10002400 10 Orange 0.500000 1.000 0.025 10002410 10 Orange, juice 0.500000 1.800 0.025 100024 11 10 Orange, juice

- babyfood 0.500000 1.800 0.025 10002420 10 Orange, peel 0.500000 1.000 0.025 04012480 4A Parsley, leaves 3.000000 1.000 1.000 06022550 6B Pea, suc culent 0.400000 1.000 1.000 06022551 6B Pea, succulent

- babyfood 0.400000 1.000 1.000 06012570 6A Pea, edible podded, succulent 0.600000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.400000 1.000 1.000 12002600 12 Peach 1.200000 1.000 0.010 12002601 12 Peach

- babyfood 1.200000 1.000 0.010 12002610 12 Peach, dried 1.200 000 7.000 0.010 12002611 12 Peach, dried

- babyfood 1.200000 7.000 0.010 12002620 12 Peach, juice 1.200000 1.000 0.010 12002621 12 Peach, juice

- babyfood 1.200000 1.000 0.010Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 26 of 28 11002660 11 Pear 1.000000 1.000 0.350 11002661 11 Pear

- babyfood 1.000000 1.000 0.350 11002670 11 Pear, dried 1.000000 6.250 0.350 110026 80 11 Pear, juice 1.000000 1.000 0.350 11002681 11 Pear, juice

- babyfood 1.000000 1.000 0.350 14002690 14 Pecan 0.100000 1.000 1.000 08002700 8 Pepper, bell 0.200000 1.000 0.025 08002701 8 Pepper, bell

- babyfood 0.200000 1.000 0.025 08002710 8 Pepper, bell, dried 0.200000 1.000 0.025 08002711 8 Pepper, bell, dried

- baby food 0.200000 1.000 0.025 08002720 8 Pepper, nonbell 0.200000 1.000 0.025 08002721 8 Pepper, nonbell

- babyfood 0.200000 1.000 0.025 08002730 8 Pepper, nonbell, dried 0.200 000 1.000 0.025 14002820 14 Pistachio 0.100000 1.000 1.000 12002850 12 Plum 1.200000 1.000 1.000 12002851 12 Plum

- babyfood 1.200000 1.000 1.000 12002860 12 Plum, prune, fresh 0.200000 1.000 1.000 12002861 12 Plum, prune, fresh

- babyfood 0.200000 1.000 1.000 12002870 12 Plum, prune, dried 0.400000 1.000 1.000 120028 71 12 Plum, prune, dried

- babyfood 0.400000 1.000 1.000 12002880 12 Plum, prune, juice 0.200000 1.400 1.000 12002881 12 Plum, prune, juice

- babyfood 0.200000 1.400 1.000 25002900 M Pork, me at 0.100000 1.000 1.000 25002901 M Pork, meat

- babyfood 0.100000 1.000 1.000 25002910 M Pork, skin 0.100000 1.000 1.000 25002920 M Pork, meat byproducts 0.200000 1.000 1.000 25002921 M Pork, meat byproducts

- babyfood 0.200000 1.000 1.000 25002930 M Pork, fat 0.100000 1.000 1.000 25002931 M Pork, fat

- babyfood 0.100 000 1.000 1.000 25002940 M Pork, kidney 0.200000 1.000 1.000 25002950 M Pork, liver 0.200000 1.000 1.000 01032960 1C Potato, chips 0.010000 1.000 0.025 01032970 1C Potato, dry (granules/ flakes) 0.010000 6.500 0.025 01032971 1C Potato, dry (granules/ flakes)

- b 0.010000 6.500 0.025 01032980 1C Potato, flour 0.010000 6.500 0.025 010329 81 1C Potato, flour

- babyfood 0.010000 6.500 0.025 01032990 1C Potato, tuber, w/peel 0.010000 1.000 0.025 01032991 1C Potato, tuber, w/peel

- babyfood 0.010000 1.000 0.025 01033000 1C Potato, tuber, w/o peel 0.010000 1.000 0.025 01033001 1C Potato, tuber, w/o peel

- babyfood 0.010000 1.000 0.025 60003010 P Poultry, other, meat 0.010000 1.000 1.000 60003020 P Poultry, other, liver 0.050000 1.000 1.000 60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 60003040 P Poultry, other, fat 0.010000 1.000 1.000 60003050 P Poultry, other, skin 0.010 000 1.000 1.000 10003070 10 Pummelo 0.500000 1.000 1.000 09023080 9B Pumpkin 0.500000 1.000 0.010 09023090 9B Pumpkin, seed 0.500000 1.000 0.010 11003100 11 Quince 1.000000 1.000 1.000 29003120 M Rabbit, meat 0.100000 1.000 1.000 04013130 4A Radicchio 3.000000 1.000 1.000 050231 80 5B Rape greens 1.200000 1.000 1.000 20003190 20 Rapeseed, oil 0.010000 1.000 1.000 20003191 20 Rapeseed, oil

- babyfood 0.010000 1.000 1.000 13013200 13A Raspberr y 1.600000 1.000 1.000 13013201 13A Raspberry

- babyfood 1.600000 1.000 1.000 13013210 13A Raspberry, juice 1.600000 1.000 1.000 13013211 13A Raspberry, juice

- babyfoo d 1.600000 1.000 1.000 04023220 4B Rhubarb 3.000000 1.000 1.000 03003380 3 Shallot 0.020000 1.000 1.000 26003390 M Sheep, meat 0.100 000 1.000 1.000 26003391 M Sheep, meat

- babyfood 0.100000 1.000 1.000 26003400 M Sheep, meat byproducts 0.200000 1.000 1.000 26003410 M Sheep, fat 0.100000 1.000 1.000 26003411 M Sheep, fat

- babyfood 0.100000 1.000 1.000 26003420 M Sheep, kidney 0.200000 1.000 1.000 26003430 M Sheep, liver 0.200000 1.000 1.000 190235 40 19B Spices, other 0.010000 1.000 1.000Acetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 27 of 28 19023541 19B Spices, other

- babyfood 0.010000 1.000 1.000 04013550 4A Spinach 3.000000 1.000 0.050 04013551 4A Spinach

- babyfood 3.000000 1.000 0.050 09023560 9B Squash, summer 0.500000 1.000 0.025 09023561 9B Squash, summer

- babyfood 0.500000 1.000 0.025 09023570 9B Squash, winter 0.500000 1.000 0.025 09023571 9B Squash, winter

- babyfood 0.500000 1.000 0.025 95003590 O Strawberry 0.600000 1.000 1.000 95003591 O Strawberry

- babyfood 0.600 000 1.000 1.000 95003600 O Strawberry, juice 0.600000 1.000 1.000 95003601 O Strawberry, juice

- babyfood 0.600000 1.000 1.000 01033660 1CD Sweet potato 0.010000 1.000 1.000 01033661 1CD Sweet potato

- babyfood 0.010000 1.000 1.000 04023670 4B Swiss chard 3.000000 1.000 1.000 10003690 10 Tangerine 0.500000 1.000 1.000 100037 00 10 Tangerine, juice 0.500000 2.300 1.000 01033710 1CD Tanier, corm 0.010000 1.000 1.000 95003720 O Tea, dried 50.000000 1.000 1.000 95003730 O Tea, ins tant 50.000000 1.000 1.000 08003740 8 Tomatillo 0.200000 1.000 1.000 08003750 8 Tomato 0.200000 1.000 1.000 08003751 8 Tomato

- babyfood 0.200000 1.000 1.000 08003760 8 Tomato, paste 0.400000 1.000 1.000 08003761 8 Tomato, paste

- babyfood 0.400000 1.000 1.000 08003770 8 Tomato, puree 0.200 000 3.300 1.000 08003771 8 Tomato, puree

- babyfood 0.200000 3.300 1.000 08003780 8 Tomato, dried 0.200000 14.300 1.000 08003781 8 Tomato, dried

- babyfood 0.200000 14.300 1.000 08003790 8 Tomato, juice 0.200000 1.500 1.000 50003820 P Turkey, meat 0.010000 1.000 1.000 50003821 P Turkey, meat

- babyfood 0.010000 1.000 1.000 500038 30 P Turkey, liver 0.050000 1.000 1.000 50003831 P Turkey, liver

- babyfood 0.050000 1.000 1.000 50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 50003841 P Turkey, meat byproducts

- babyfood 0.050000 1.000 1.000 50003850 P Turkey, fat 0.010000 1.000 1.000 50003851 P Turkey, fat

- babyfood 0.010000 1.000 1.000 50003860 P Turkey, skin 0.010000 1.000 1.000 50003861 P Turkey, skin

- babyfood 0.010000 1.000 1.000 01033870 1CD Turmeric 0.010000 1.000 1.000 05023890 5B Turnip, greens 1.200 000 1.000 1.000 14003910 14 Walnut 0.100000 1.000 1.000 86010000 O Water, direct, all sources 0.005000 1.000 1.000 86020000 O Water, indirect, all sources 0.005000 1.000 1.000 09013990 9A Watermelon 0.500000 1.000 1.000 09014000 9A Watermelon, juice 0.500000 1.000 1.000 01034060 1CD Yam, true 0.010000 1.000 1.000 010340 70 1CD Yam bean 0.010000 1.000 1.000 

### Attachment 6

. Summary

of DEEM

- FCIDTM Chronic Results
U.S. Environmental Protection Agency Ver. 2.00 DEEM

- FCID Chronic analysis for ACETAMIPRID (1994

- 98 data) Residue file name: C: \ Documents and Settings \ dmcneill \ My Documents \ Actemidprid \ PRIADNTacetamipridCT_chronic.R98 Adjustment factor #2 used. Analysis Date 01

- 12

- 2010/08:15:46 Residue file dated: 01

- 12

- 2010/08:15:02/8 Reference dose (RfD, Chronic) = .071 mg/kg bw/day COMMENT 1: Acute/Chronic

- UFs = 100

=============================================================================== Total exposure by popul ation subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Popula tion mg/kg Percent of Subgroup body wt/day RfdAcetamiprid Dietary Exposure and Risk Assessment DP No.: 3 72890

PC Code: 099050



### Page 28 of 28 -------------------------------------- ------------- --------------- U.S. Population (total) 0.002835 4.0% U.S. Population (spring season) 0.002861 4.0% U.S. Population (summer season) 0.003114 4.4% U.S. Population (autumn season) 0.002700 3.8% U.S. Population (winter season) 0.002660 3.7% Northeast region 0.002940 4.1% Midwest region 0.002864 4.0% Southern region 0.002639 3.7% Western region 0.003022 4.3% Hispanics 0.002916 4.1% Non

- hispanic whites 0.002817 4.0% Non

- hispanic blacks 0.002589 3.6% Non

- hisp/non

- white/non

- black 0.003635 5.1% All infants (< 1 year) 0.005206 7.3% Nursing infants 0.002502 3.5% Non

- nursing infants 0.006232 8.8% Children 1

- 6 yrs 0.008045 11.3% Children 7

- 12 yrs 0.003764 5.3%
Females 13

- 19 (not preg or nursing) 0.002017 2.8% Females 20+ (not preg or nursing) 0.002107 3.0% Females 13

- 50 yrs 0.002212 3.1% Females 13+ (preg/ not nursing) 0.002362 3.3% Females 13+ (nursing) 0.002580 3.6%
Males 13

- 19 yrs 0.002313 3.3% Males 20+ yrs 0.00201 3 2.8% Seniors 55+ 0.002162 3.0%
Children 1

- 2 yrs 0.010358 14.6% Children 3

- 5 yrs 0.007296 10.3% Children 6

- 12 yrs 0.004055 5.7% Youth 13

- 19 yrs 0.002170 3.1% Adults 20

- 49 yrs 0.002031 2.9% Adults 50+ yrs 0.002130 3.0% Females 13

- 49 yrs 0.002057 2.9%

-------------------------------------------------------------------------------