Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 1 of 60 

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OF FICE OF CHEMICAL SAFETY AND

POLLUTION PREVENTION



### MEMORANDUM

Date: 04 / 14 / 2016

SUBJECT: Abamectin : PP# 4E8309

, 3E8175, and 3F8184 Acute and Chronic Aggregate

Dietary (Food and Drinking Water) Exposure and Risk Assessments for Section 3

Registration Action s for Four Separate New Use Actions and Tolerance Petitions :

(1) New Uses on Bean, Papaya, Star Apple, Black Sapote, Sapodilla, Can istel,

Mamey Sapote, Guava, Feijoa, Jaboticaba, Wax Jambu, Starfruit, Passionfruit,

Acerola, Lychee, Longan, Spanish Lime, Rambutan, Pulasan, Pineapple; Onion,

Green, Subgroup 3

- 07B; Fruit, Pome, Group 11

- 10; Fruit, Small Vine Climbing,

except Fuzzy Kiwifruit, Subgroup 13

- 07F; Berry, Low Growing, Subgroup 13

- 07G; and Conversion of Existing Crop Groups to Vegetable, Fruiting, Group 8

- 10

(and Addition of Gr eenhouse

- grown Tomato); Fruit, Citrus, Group 10

- 10; Fruit,

Stone, Group 12

- 12; and Nut, Tree, Group 14

- 12

. (2) New Uses on Caneberry

Subgroup 13

- 07A. (3) Sweet Corn and Soybeans. And (4) Cattle Ear Tag on

Lactating Cattle.

PC Code: 122804 DP Barcode : D424009

, D421348

Decision No s .: 495169 , 480190 , 476238

, 478520 Registration No s

. : 100

- 1154, 100

- 1351, 100

- 1 408, and

100

- 1439 , 100

- 898, 100

- 1350, and 39039

- 17

Petition No s .: 4E8309

, 3E8175, 3F8184 Regulatory Action: Section 3 Registration

Risk Assessment Type: Dietary Case No.: 7430

T XR No.: N A CAS No.: 71751

- 41

- 2

MRID No.: N A 40 CFR: § 180.449

FROM : Nancy Dodd, Chemist

Kristin Rickard, Biologist

Risk Assessment Branch III (RAB3)

Health Effects Division (HED) (7509P)

THROUGH: Julie VanAlstine, DESAC Reviewer

Doug Dotson, DESAC Reviewer

And

Christine Olinger, Branch Chief

RAB3/HED (7509P)Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 2 of 60 

### TO: Laura Nollen, Biologist

RAB3/HED (7509P)

and

Mark Suarez / Jessica Rogala, RM#1

Registration Division (7505P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exp osure and risk assessments were

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity

Intake Database (DEEM

- FCID)

, Version 3.16. This soft ware uses 2003

- 2008 food consumption

data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition

Examination Survey, What We Eat in America (NHANES/WWEIA) . The analys es were

conducted in support of a human health risk assessment for three separate petitions for the

insecticide/miticide, abamectin:

• 4E8309: The Interregional Project No. 4 (IR

- 4) has proposed a Section 3 registration of

abamectin on bean, papaya, star apple, black sapote, sapodilla, canistel, mamey sapote,

guava, feijoa, jaboticaba, wax jambu, starfruit, passionfruit, acerola, lychee, longan,

Spanish lime, rambutan, pulasan, pineapple; onion, green, subgroup 3

- 07B; fruit, pome,

gr oup 11

- 10; fruit, small vine climbing, except fuzzy kiwifruit, subgroup 13

- 07F; berry,

low growing, subgroup 13

- 07G; and conversion of existing crop groups to vegetable,

fruiting, group 8

- 10 (and addition of greenhouse

- grown tomato); fruit, citrus, group 1 0

- 10;

fruit, stone, group 12

- 12; and nut, tree, group 14

- 12.

• 3E8175: IR

- 4 has proposed a Section 3 registration of abamectin on caneberry subgroup

13

- 07A.

• 3F8184: Syngenta Crop Protection (Syngenta) has proposed a Section 3 registration of

abamectin in/ on sweet corn and soybeans.

In addition, the registrant Y

- TEX Corporation, submitted a Section 3 request for a cattle ear tag

containing abamectin for use on lactating cattle. An ear tag use has been registered on beef cattle

and non

- lactating dairy cattle.

This memorandum was reviewed by two peer reviewers of the DESAC ( Julie VanAlstine and

Doug Dotson )

, per DESAC Standard Operating Procedure ( SOP ) 2012.1 and was discussed by the

DESAC on April 14, 2016

.

Acute Dietary (Food and Drinking Water) Exposure Assessment

A refined acute dietary (food and drinking water) exposure assessment was conducted for all

proposed and established food uses of abamectin . Acute anticipated residues derived from field

trial data were used

. Empirical and d efault processing fac tors and percent crop treated (% CT)

estimates were used

, as available. Surface drinking water concentrations were estimated using the

Tier II surface water concentration calculator ( SWCC ) com puter model. The model predicts thatAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 3 of 60 

### the maximum concentration of total residues of abamectin in surface water (the 1

- in

- 10

- year peak

exposure) is not likely to exceed 0.76 ppb from the proposed uses

. A residue distribution file of

e stimated drinking water concentrations (EDWCs) from the Env ironmental Fate and Effects

Division (EFED) was used in the acute assessment.

The acute dietary exposure estimates for food and drinking water are not of concern (<100%

aPAD) at the 99.9 th 

### percentile of exposure for the general U.S. population and all population

subgroups . Abamectin dietary exposure at the 99.9 th 

### percentile for food and drinking water is 4 5 %

of the aPAD for the general U.S. population and 88 % of the aPAD for children 1

- 2 years old, the

most high ly exposed population subgroup

.

Chronic Dietary (Food and Drinking Water) Exposure Assessment

A refined chronic dietary (food and drinking water) exposure assessment was conducted for all

proposed and established food uses of abamectin

. Average residues from field trials were used.

Residues from use in food handling establishments were included. Empirical and d efault

processing factors and % CT estimates were used

, as available. Drinking water was represented

by a single point estimate of average abam e ctin residues (the 1

- in

- 10

- year annual mean) . The

estimated surface water concentration of 0.30 ppb was based on the a pplication to beans.

The chronic dietary exposure estimates for food and drinking water are not of concern (< 100%

cPAD) for the general U.S. population and all population subgroups. Abamectin dietary exposure

for food and drinking water is 2. 2 % of the cPAD for the general U.S. population and 11 % of the

cPAD for children 1

- 2 yrs old, the most highly exposed popul ation subgroup

.

Cancer Dietary (Food and Drinking Water) Exposure Assessment

Since abamectin is classified as “not likely to be carcinogenic to humans,” a cancer dietary

exposure assessment is not required.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e.,

the dose that HED has concluded will result in no unreasonab le adverse health effects). This dose

is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of

departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more

detail are available on the EPA/pesticides web site: “Available Information on Assessing

Exposure fro m Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link:

http://www.regulations.gov/#!documentDetail;D=EPA

- HQ

- OPP

- 2007

- 0780

- 0001 ; or see SOP

99.6 (20

- AUG

- 1999).Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 4 of 60 

### The most recent dietary risk assessment for abamectin was conducted in 2014 ( N

. Dodd

, , D421348

, 10/28/ 20 14 ).

II. Residue Information

Tolerances have been established in 40 CFR §180.449(a) for residues of abamectin ( avermectin ),

including its metabolites and degradates, in or on various plant and livestock commodities at levels

ranging from 0.005 to 1.0 ppm , and for use in food handling establishments at 0.01 ppm

. Compliance with the tolerance levels is to be determined by mea suring only avermectin B 1 

### [a

mixture of avermectins containing greater than or equal to 80% avermectin B 1a 

### (5

- O

- demethyl

avermectin A 1 

### ) and less than or equal to 20% avermectin B 1b 

### (5

- O

- demethyl

- 25

- de(1

- methylpropyl)

- 25

- (1

- methylethyl) avermectin A 1 

### )] and its delta

- 8,9

- isomer

.

The Interregional Research Project No. 4 (IR

- 4), on behalf of the Agricultural Experiment Stations

of California ( CA )

, Delaware (DE), Florida (FL), Hawaii ( HI )

, Oregon ( OR )

, Puerto Rico (PR),

South Carolina ( SC )

, and Tennessee ( TN ) propose d establishment of tolerances for new uses on

bean, papaya, star apple, black sapote, sapodilla, canistel, mamey sapote, guava, feijoa, jaboticaba,

wax jambu, starfruit, passionfruit, acerola, lychee, longan, Spanish lime, rambutan, pulasan,

pinea pple; onion, green, subgroup 3

- 07B; fruit, pome, group 11

- 10; fruit, small vine climbing,

except fuzzy kiwifruit, subgroup 13

- 07F; berry, low growing, subgroup 13

- 07G; and conversion of

existing crop groups to vegetable, fruiting, group 8

- 10 (and addition of greenhouse

- grown tomato);

fruit, citrus, group 10

- 10; fruit, stone, group 12

- 12; and nut, tree, group 14

- 12. Syngenta Crop

Protection LLC (Syngenta) has submitted PP# 3F8184 to request the establishment of permanent

tolerances for residues of abamectin on sweet corn commodities (forage, kernel plus cob with husk

removed, and stover) and soybean commodities (forage, hay, and seed). The Interregional

Research Project No. 4 (IR

- 4), on behalf of the Agricultural Experiment Stations of Arkansas

( AR )

, CA, DE , North Carolina ( NC )

, SC, and Washington ( WA ) has submitted pesticide petition

(PP#) 3E8175 to request the establishment of permanent tolerances for residues of abamectin on

Caneberry subgroup 13

- 07A.

Finally, Y

- TEX Corporation has requested registrati on of an ear tag containing abamectin and

piperonyl butoxide for use on lactating dairy cattle. An ear tag use has been registered on beef

cattle and non

- lactating dairy cattle. Tolerances for abamectin on fat, meat, and meat byproducts of

cattle were prev iously increased to reflect that use. This review concerns residues in milk. No

increase in the tolerance on milk was proposed. This review concerns only abamectin; piperonyl

butoxide has been under separate review.

HED is recommending for the establishm ent of the following permanent toleranc es.

Acerola

................................ ................................ ................................ .. 0.015 ppm

Bean

................................ ................................ ................................ ....... 0.015 ppm

Berry, low growing, subgroup 13

- 07G

................................ .................. 0.05 ppm

Black sapote

................................ ................................ ........................... 0.40 ppmAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 5 of 60 

### Caneberry subgroup 13

- 07A

................................ ................................ .. 0.20 ppm

Canistel

................................ ................................ ................................ ... 0.40 ppm

Cattle, fat

................................ ................................ ................................ 0.05 ppm

Cattle, meat

................................ ................................ ............................. 0.02 ppm

Cattle, meat b yproducts

................................ ................................ .......... 0.09 ppm

Corn, sweet, forage

................................ ................................ ................. 0.20 ppm

Corn, sweet, kernel plus cob with husk removed

................................ ... 0.01 ppm

Corn, sweet, stover

................................ ................................ ................. 0.50 ppm

Feijoa

................................ ................................ ................................ ..... 0.015 ppm

Fruit, citrus, group 10

- 10

................................ ................................ ........ 0.02 ppm

Fruit, pome, group 11

- 10

................................ ................................ ........ 0.02 ppm

Fruit, stone, group 12

- 12

................................ ................................ ........ 0.09 ppm

F ruit, small vine climbing, except fuzzy kiwifruit, subgroup 13

- 07F

.... 0.02 ppm

Goat, fat

................................ ................................ ................................ .. 0.03 ppm

Goat, meat

................................ ................................ .............................. 0.02 ppm

Goat, meat byproducts

................................ ................................ ............ 0.04 ppm

Grain, aspirated grain fractions

................................ .............................. 0.40 ppm

Guava

................................ ................................ ................................ ..... 0.015 ppm

Hog, fat

................................ ................................ ................................ ... 0.01 ppm

Hog, meat

................................ ................................ ............................... 0.02 ppm

Hog, meat byproducts

................................ ................................ ............. 0.02 ppm

Horse, fat

................................ ................................ ................................ 0.03 ppm

Horse, meat

................................ ................................ ............................. 0.02 ppm

Horse, meat byproducts

................................ ................................ .......... 0.04 ppm

Jaboticaba

................................ ................................ .............................. 0.015 ppm

Longan

................................ ................................ ................................ .... 0.01 ppm

Lychee

................................ ................................ ................................ .... 0.01 ppm

Mamey sapote

................................ ................................ ......................... 0.40 ppm

Milk

................................ ................................ ................................ ....... 0.015 ppm

Nut, tree, group 14

- 12

................................ ................................ ............ 0.01 ppm

Onion, green, subgroup 3

- 07B

................................ ............................... 0.08 ppm

Pa paya

................................ ................................ ................................ .... 0.40 ppm

Passionfruit

................................ ................................ ............................ 0.015 ppm

Pineapple

................................ ................................ ............................... 0.015 ppm

Poultry, meat

................................ ................................ .......................... 0.02 ppm

Poultry, meat byproducts

................................ ................................ ........ 0.02 ppm

Pulasan

................................ ................................ ................................ .... 0.01 ppm

Rambutan

................................ ................................ ................................ 0.01 ppm

Sapodilla

................................ ................................ ................................ . 0.40 ppm

Sheep, fat

................................ ................................ ................................ 0.03 ppm

Sheep, meat

................................ ................................ ............................ 0.02 ppm

Sheep, meat byproducts

................................ ................................ .......... 0.04 ppm

Soybean, forage

................................ ................................ ...................... 0.30 ppm

Soybean, hay

................................ ................................ ........................... 1.0 ppmAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 6 of 60 

### Soybean, seed

................................ ................................ ......................... 0.01 ppm

Spanish lime

................................ ................................ ........................... 0.01 ppm

Star apple

................................ ................................ ................................ 0.40 ppm

Starfruit

................................ ................................ ................................ .. 0.015 ppm

Vegetable, fruiting, group 8

- 10

................................ .............................. 0.07 ppm

Wax jambu

................................ ................................ ............................ 0.015 ppm

The nature of the residue in plants and livestock is adequately understood. T he residues of

concern (ROCs) for the risk assessment are avermectin B 1a

, 

### avermectin B 1b



### , and their delta

- 8,9

- isomers (also known as 8,9

- Z isomers)

.

Th e drinking water asse ssment provides screening

- level EDWCs of the residues of concern, which

include abamectin and the structurally similar degradates, NOA 448111, NOA 448112, NOA

426289, NOA 445495, NOA 457464, and NOA 457465 (G

. Orrick, D412861, 5/15/ 20 14).

EPA is now including residues in fish/catfish in the dietary exposure assessment if they are

reported by the USDA Pesticide Data Program (PDP ) . PDP monitored pesticide residues in catfish

in 2008, 2009, and 2010 and in salmon in 2013 and 2014 ; however, th e samples were n ot analyzed

for abamectin or avermectin. As a result, PDP residues in fish were not included in this

assessment

.

Data U sed for Acute Assessment :

Anticipated residues b ased on field trial s were used for agricultural commodities

. Tolerance

- level

residues were used for livestock commodities except for milk, for which the calculated residue

value of 0.011 ppm was used instead of the tolerance of 0.015 ppm. The SOP for field trial data

(HED SOP 2000.1) was used to translate residue d ata from representative crops of crop groups to

other members of the crop groups. For livestock commodities, residue distribution files were used

based on tolerance

- level residues , maximum percent crop treated, and the maximum residue for

the feed items

. (R e fer to the Anticipated Residues Summary Table, Attachment 1

, the Acute

Residue Distribution Files, Attachment 2 , and The Calculation of Livestock Anticipated Residues,

Attachment 13

. ) No monitoring data were used. The % CT data provided by BEAD in 201 5

(“U pdated Screening Level Usage Analysis (SLUA) Report for Abamectin, PC Code 122804,” No

DP Number, J Alsadek, 7/1/ 20 15 and “Percent Crop Treated for Abamectin (122804) on IR4

Proposed New Use on Caneberries and New Foliar Use on Soybeans and Sweet C orn,” D42 8074

, D Atwood, 8/27/ 20 15 ) were used

. ( Refer to Attachment 1 2 for tabulated percent crop treated

data.) E mpirical processing factors generated in processing studies were used for apple juice

(0.073 x ), chive, dried leaves (2.9x), grape juice (0.47x) , raisin (0.75x) , citrus oil (9.7x), grapefruit

juice (0.85x), other citrus juice s (0.25x), peel of lemon and orange (2.5x) , dried prune (3.9x)

, tomato juice (0.21x) , tomato paste (1.2x), and tomato puree (0.40x)

. The available D EEM 7.81

default p rocessing factors were used for commodities for which empirical processing factors are

not available.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 7 of 60 

### Data Used for Chronic Assessment :

A verage field trial residue levels were used for agricultural commodities

. Tolerance

- level residues

were used for livestock commodities except for milk, for which the calculated residue value of

0.011 ppm was used instead of the tolerance of 0.015 ppm. The S OP for field trial data (HED SOP

2000.1) was used to translate residue d ata from representative crops of crop groups to other

members of the crop groups.

Abamectin residues in food handling establishments were reported as <0.001 ppm, the stated LOQ

of the method (D283818, J. Morales, 11/20/2003; D310414, N. Dodd, 12/1/2004) . For

commodities which could be exposed only in food handling establishments, a value of 1⁄2 LOD

(0.0002 ppm) was assigned (D283818, J. Morales, 11/20/2003). If any commodity residue value

was less than the food handling establishment (FHE) value, then 1⁄2 LOD (0.0002 ppm) was used.

For commodities assigned the FHE value, the processing factor was set to 1 and the % CT was set

to 5% (DP# 413125, J. Becker, 10/7/2014). (Refer to the Anticipated Residues Summary Table,

Attachment 1, and the Chronic Point Est imates, Attachment 2.) No monitoring data were used.

The % CT data provided by BEAD in 2015 (cited above) were used for the agricultural

commodities (i.e., the non

- FHE uses)

.

Empirical processing factors generated in processing studies were used for apple juice (0.073x),

chive, dried leaves (2.9x), grape juice (0.47x), raisin (0.75x), citrus oil (9.7x), grapefruit juice

(0.85x), other citrus juices (0.25x), peel of lemon and orange (2.5x), dried prune (3.9x), tomato

juice (0.21x), tomato paste (1.2x), and tomato puree (0.40x). The available DEEM 7.81 default

processing factors were used for commodities for which empirical processing factors are not

available.

For livestock commodities, residue level s are based on the maximum reasonable dietary burden for

secondary residues in livestock and the highest residue found in the magnitude of residue studies

for cattle ear tags. The percent crop treated for livestock commodities is based on the PCT value

for the livestock feed item used in the dietary burden with the highest percent crop treated. The

dietary burden estimates were highe r for dairy cattle than beef cattle, sweet corn forage PCT

estimates were the highest of the PCT estimates for feed items use d in the diet ( a maximum of

57% for acute estimates, and 45% for chronic/background estimates ) . The dietary burden

estimates were very low for poultry and swine (as noted in Attachment 13) , which would result in

secondary residues considerably lower than the current tolerances that are based on the FHE use.

Therefore, tolerance values were used for poultry and swine, and the PCT for FHE was used. The

PCT values for poultry and swine feed items were not used, as they would lead to an overestimate

of expos ure. Although residues from FHE are not usually used in an acute exposure assessment,

the tolerance levels for poultry and swine were used to account for poultry and swine consuming

treated feed.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 8 of 60 

### III. Percent Crop Treated Information

As tabulated in Attachment 12 , t he following maximum percent crop treated estimates provided by

BEAD ( No DP Number

, J Alsadek

, 7/1/ 20 15 and D42 8074 , D Atwood, 8/27/ 20 15 ) were used in

the acute dietary risk assessment for the following crops for abamectin: a lmond: 80 %; a pple: 3 0%;

a pricot: 3 0 %; a vocado: 60%; bean, dry: 2.5%; blackberr y : 68 %; boysenberr y : 68%; c antaloupe:

4 5 %; c elery: 70 %; c herr y : 20 %; corn, sweet : 57 %; c otton: 30 %; c ucumber: 10%; grape: 35%;

g rapefruit: 90 %; hazelnut: 2.5%; h oneydew: 35 %; l emon: 55 %; l ettuce: 4 5 %; loganberr y : 68%;

nectarine: 20%; onion, bulb: 10%; o range: 7 0 %; p each: 25 %; p ear: 85 %; p ecan: 2.5 %; p epper:

30 %; pistachio: 2.5%; plum/prune: 35%; p otato: 20 %; p umpkin: 10 %; raspberr y : 68 %; soybean:

11%; s pinach: 45 %; s quash: 15 %; s trawberr y : 45 %; t angerine: 5 5 %; t omato: 25 %; w alnut: 55 %;

and w atermelon: 15 %.

The following average percent crop treated estimates provided by BEAD (No DP Number, J

Alsadek, 7/1/ 20 15 and D428074, D Atwood, 8/27/ 20 15) were used in the chronic dietary risk

assessment for the following crops for abamectin: a lmond: 70 %; a pple: 10 %; a pricot: 1 5 %;

a vocado: 35 %; bean, dry: 2.5%; blackberr y : 56 %; boysenberry: 56%; c antaloupe: 2 5 %; c elery:

45 %; c herr y : 5 %; corn, sweet : 45 %; c otton: 20 %; c ucumber: 5 %; grape: 15%; g rapefruit: 7 0 %;

hazelnut : 2.5%; h oneydew: 20 %; l emon: 40 %; l ettuce: 2 0 %; loganberry: 56%; nectarine: 20%;

onion, bulb: 2.5%; o range: 40 %; p each : 10 %; p ear: 7 0 %; p ecan: 1 %; p epper: 15 %; pistachio:

2.5 %; plum/prune: 10%; p otato: 5 %; p umpkin: 5 %; raspberr y : 56 %; soybeans: 8%; s pinach: 25 %;

s quash: 5 %; s trawberr y : 3 0 %; t angerine: 35 %; t omato: 1 0 %; w alnuts: 25 %; and w atermelons: 5 %.

All commodities included for food handling residues were assigned the value of 5% CT (DP#

413125, J. Becker, 10/7/2014).

The percent crop treated values that were used to refine the livestock commodities for the acute

assessment were based on: sweet corn ( 57 %) for beef, goat, horse, and sheep commodities; and the

food handling establishment uses (5%) for hog and poultry meat and meat byproducts.

The percent crop treated values that were used to refine the livestock commodities for the chronic

assessment were based on: sweet corn (45%) for beef, goat, horse, sheep meat, fat, and meat

byproducts; and the food handling estab lishment uses (5%) for hog and poultry meat and meat

byproducts.

IV. D rinking Water Data

The proposed new uses for abamectin are not expected to generate higher EDWCs than those

previously generated (G. Orrick, D412861, 05/15/2014)

.

The drinking water residues used in the dietary risk assessment were provided by the

Environmental Fate and Effects Division ( EFED ) in the following memorandum: “ Abamectin:

Drinking Water Exposure Assessment for Proposed New Uses on Soybeans, Sweet Corn,

C aneberries (Crop Group 13

- 07A), and Golf Course Tees, Greens, and Fairways” (D412861, G.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 9 of 60 

### Orrick, 5/15/14) and incorporated directly in to this dietary assessment. Water residues were

incorporated in the DEEM

- FCID into the food categories “water, direct, al l sources” and “ water,

indirect, all sources.” The Tier II SWCC model was used to obtain the EDWC s from surface

water

. The Tier I Pesticide Root Zone Model

- Ground Water (PRZM

- GW) and Tier I Screening

Concentration in Ground Water ( SCI

- GROW ) model s w ere used to assess residues in ground

water. The EDWCs used in the acute and chronic assessments are the residues in surface water

since the residues in ground water are lower. Considering all registered/proposed uses, the

proposed use on soybeans in MS at 0.037 lb ai/A/year results in the highest acute drinking water

exposure and the registered use on beans in MI at 0.056 lb ai/A/year results in the highest chronic

drinking water exposure

. For the acute EDWC, the 1

- in

- 10 y ea r annual maximum concentration

was 0.76 ppb in surface water

, as shown in Table 1 below

. This value was not used in the

assessment, however. Instead, HED used a residue distribution file for water provided by EFED.

For the chronic assessment, the annual mean concentration of 0.30 ppb in surface water was used.

Table 1. Screening

- Level ROC EDWCs for Proposed Uses of Abamectin A

Source (Tier: Model) Use Site

(Max. Annual App. Rate) Acute EDWC

(μg/L) Chronic

EDWC

(μg/L)

Surface water (Tier II: SWCC) Soybeans (0.037 lbs a.i./A)/

Beans (0.056 lbs a.i./A) 0.76

(soybeans) 0.30

(beans)

Ground water (Tier I: PRZM

- GW) Golf courses (0.27 lbs a.i./A) 0.074 N/A

Ground water (Tier I: SCI

- GROW) Golf courses (0.27 lbs a.i./A) ≤0.0031

A Maximum values in bold.



### The drinking water model s and their description s are available at the EPA internet site:

http://www.epa.gov/oppefed1/models/water/

.

V. DEEM

- FCID Program and Consumption Information

Abamectin acute and chronic dietary exposure assessments were conducted using the DEEM

FCID

, Version 3.16, which incorporates 2003

- 2008 consumption data from USDA’s

NHANES/WWEIA. The da ta are based on the reported consumption of more than 20,000

individuals over two non

- consecutive survey d ays. Foods “as consumed” (e.g., apple pie) are

linked to EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S; baked;

or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files

developed join tly by USDA/ARS and EPA. For chronic exposure assessment, consumption data

are averaged for the entire U.S. population and within population subgroups . However, for acute

exposure assessment

, consumption data are retained as individual consumption events . Based on

analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns

and survey respondents, HED concluded that it is most appropriate to report risk for the following

population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children

3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or o range juice) on the food commodity residue list is multiplied by the averageAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 10 of 60 

### daily consumption estimate for that food/food form to produce a residue intake estimate. The

resulting residue intake estimate for each food/food form is summed with the residue intake

estimates for all other food/food forms on the commodity residue list to arrive at the total average

estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the

cPAD. This procedure is performed for each population s ubgroup.

For acute exposure assessments, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a

deterministic exposure assessment, or “matched” in multiple random pairings with residue values

and then summed in a probabilistic assessment. The resulting distribution of exposures is

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant

commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant

commodities as well as those who did not) basis. In accordance with HED policy, per capita

exposure and r isk are reported for analyses performed at all levels of refinement. However, for

deterministic assessments, any significant differences in user vs. per capita exposure and risk are

specifically identified and noted in the risk assessment.

V I

. Toxicologi cal Information

The Toxicology Science Advisory Council ( ToxSAC ) met on 9/11/14 to reassess toxicological

endpoints for abamectin. The resulting toxicological endpoint s are shown in Table 2.

Acute Dietary Exposure Endpoint

For the acute dietary exposure, tremors and mydriasis seen in the subchronic (12

- and 18

- weeks)

and chronic oral toxicity studies in dogs at the LOAEL of 0.5 mg/kg were selected as toxicity

endpoints because tremors and mydriasis could be elicited by a single dose acting on the GABA

receptors. The point of departure (NOAEL) was 0.25 mg/kg. There are 3 sets of data which

support this selection: (1) kinetics data supports rapid absorption/excretion, (2) acute neurotoxicity

was observed in rats, and (3) the effects produced by ab amectin in beagle dogs did not progress

with time.

Kinetic data : Given the rapid absorption and elimination of abamectin, the Agency has concluded

that the neurotoxic effects seen in the subchronic and chronic toxicity studies in dogs could be

elicited b y a single dose. As described previously, the kinetic data of abamectin show a pattern of

rapid absorption and elimination. The proposed endpoint is, therefore, supported by the kinetics

data. With oral dosing in rats, abamectin was absorbed rapidly, an d maximum concentration in

blood was achieved within 4

- 8 hours after administration. It was rapidly eliminated from the

body, almost exclusively in the feces, and did not accumulate in the body after repeated exposure.

The results of an abamectin kinetic study in wild type CF

- 1 mice (with fully functional P

- gp) were

consistent with kinetic results in rats: following a single oral administration, abamectin was rapidly

absorbed, time to peak blood and plasma concentration was approximately 4 hours after dos ing,

and elimination was also fast, mainly by fecal route. In the CF

- 1 mouse, elimination expressed as

percentage of the administered dose at various times after dosing were: 47

- 56% by 12 hours, 73

-Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 11 of 60 

### 81% by 24 hours, and greater than 90% by 48 hours.

Acute neurotoxicity study in rats : The conclusion based on the kinetics data was confirmed by

results from the acute neurotoxicity study in rat (range finding and main studies) which showed

that, with a single dose, the treated rats developed clinical signs of neurotoxicity such as reduced

foot splay reflex, ataxia, tremors, and mydriasis (decreased pupillary light response). Most of

these effects were consistent with those seen in the subchronic and chronic dog studies, except in

rats the effects were observed at higher dose levels as rats were relatively less sensitive to the

effects of abamectin relative to the beagle dogs

. Therefore, tremors and mydriasis seen in the dog

studies could be due a single dose.

Effects seen in the subchronic and chronic dog s tudies: The effects seen in the subchronic

(gavage) and chronic dog studies were similar despite repeated dosing, suggesting the response

could be due to each individual exposure rather than to accumulation of abamectin in tissues.

Purportedly, as the pea k blood level of each administered dose passed, the response diminished or

disappeared accordingly.

Safety factor for acute dietary exposure risk assessment: In previous risk assessments, an

additional safety factor of 3x to account for the steepness of dose was employed. With the present

analysis, the addition al 3x safety factor is not necessary because a clear NOAEL was established in

the dog studies used for toxicity endpoint selection. A total safety factor of 100x (10x for

interspecies extrapolatio n and 10x for intraspecies variations) is appropriate and sufficient in

establishing the acute reference dose (aRfD) (0.0025 mg/kg/day) for abamectin.

Chronic Dietary Exposure Endpoint

For chronic dietary exposure toxicity endpoints, tremors and mydriasis were selected based on the

results of the subchronic and chronic oral toxicity studies in dogs. The point of departure i s 0.25

mg/kg/day (NOAEL). The adverse clinical signs were seen in both studies at a similar LOAEL

(0.5 mg/kg/day). A total safety fac tor of 100x (10x for interspecies extrapolations and 10x for

intraspecies variations) is appropriate and sufficient in establishi ng the chronic reference dose

(c RfD ; 0.0025 mg/kg/day) for abamectin.

Table 2. Summary of Toxicity Endpoints and Points of Departure for Abamectin

Exposure/

Scenarios Point of

Departure Uncertainty/F

QPA Safety

Factor RFD, PAD,

Level of

Concern

(LOC) Study and Toxicological Effects

Acute Dietary

(General

Population,

including

Infants and

Children) NOAEL

= 0.25

mg/kg/day UF A = 10x

UF H = 10x

FQPA SF = 1 x Acute RfD =

0.0025

mg/kg/day

aPAD =0.0025

mg/kg/day Subchronic & chronic oral toxicity

studies in dogs

Chronic LOAEL = 0.50 mg/kg/day

based on body tremors, one death, liver

pathology, decreased body weight.

Mydriasis was seen during week one in

one dog.

Subchronic LOAEL=0.5 mg/kg/day

based on mydriasis during week one,

death at 1.0 mg/kg/day.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 1 2 of 60

Table 2. Summary of Toxicity Endpoints and Points of Departure for Abamectin

Exposure/

Scenarios Point of

Departure Uncertainty/F

QPA Safety

Factor RFD, PAD,

Level of

Concern

(LOC) Study and Toxicological Effects

Chronic Dietary

(All

Populations) NOAEL

= 0.25

mg/kg/day UF A = 10x

UF H = 10x

FQPA SF = 1x Chronic RfD =

0.0025

mg/kg/day

cPAD =

0 .0025

mg/kg/day Subchronic & Chronic and 90

- day oral

toxicity studies in Dogs

Chronic LOAEL = 0.50 mg/kg/day

based on body tremors, one death, liver

pathology, decreased body weight.

Mydriasis was seen during week one in

one dog.

Subchronic LOAEL=0.5 mg/kg/day

based on mydriasis during week one,

death at 1.0 mg/kg/day.

Cancer (oral,

dermal,

inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on the absence of significant

tumor increases in two adequate rodent carcinogenicity studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF =

uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity

among members of the human population (in traspecies). FQPA SF = FQPA Safety Factor. PAD = population

adjusted dose (a = acute, c = chronic). RfD = reference dose. LOC = level of concern.



### VI I

. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds

100% of the PAD. The DE EM

- FCID analyses estimate the dietary exposure and risk of the U.S.

population and various population subgroups. The results reported in Table s 3 and 4 are for the

general U.S. p opulation, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth

13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years old

.

Results of Acute Dietary (Food and Drinking Water) Exposure and Risk Analysis

Abamectin dietary exposure at the 99.9 th 

### percentile for food and drinking water is 4 5 % of the

aPAD f or the general U.S. population and 8 8 % of the aPAD for children 1

- 2 years old, the most

highly exposed population subgroup. The results of the acute dietary exposure analysis at the 95 th



### , 99 th 

### , a nd 99.9 th 

### percentiles of exposure are reported in Table 3

.

Table 3 . Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

Population Subgroup aPAD

(mg/kg/day) 95 th Percentile 99 th Percentile 99.9 th Percentile

Exposure

(mg/kg/day) %

aPAD Exposure

(mg/kg/day) %

aPAD Exposure

(mg/kg/day) %

aPAD

General U.S. Population 0.00 2 5 0.000228 9.1 0.000548 22 0.001135 45Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 13 of 60 Table 3 . Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

Population Subgroup aPAD

(mg/kg/day) 95 th Percentile 99 th Percentile 99.9 th Percentile

Exposure

(mg/kg/day) %

aPAD Exposure

(mg/kg/day) %

aPAD Exposure

(mg/kg/day) %

aPAD

All Infants (< 1 year old) 0.000391 16 0.001077 43 0.001584 63

Children 1

- 2 years old * 0.000959 38 0.001402 56 0.002192 88

Children 3

- 5 years old 0.000554 22 0.000789 32 0.001553 62

Children 6

- 12 years old 0.000341 14 0.000497 20 0.000729 29

Youth 3

- 19 years old 0.000173 6.9 0.000286 11 0.000475 19

Adults 20

- 49 years old 0.000132 5.3 0.000219 8.8 0.000446 18

Adults 50

- 99 years old 0.000122 4.9 0.000199 8.0 0.000345 14

Females 13

- 49 years old 0.000134 5.4 0.000229 9.2 0.000427 17

*The subpopulation with the highest risk estimates a t the 99.9 th percentile is bolded

.



### Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

HED notes that the PODs selected for assessing acute and chronic dietary exposure are the same;

because of the conservative, high

- end nature of the inputs into an acute dietary exposure

assessment, usually if the PODs are the same for both acute and chroni c durations, only an acute

dietary exposure assessment is conducted. However, a chronic dietary exposure assessment has

been conducted for abamectin for the purposes of generating a dietary (food and drinking water)

exposure estimate for the aggregate assessment and to incorporate residues/exposure from the food

handling establishment (FHE) uses.

Abamectin dietary exposure for food and drinking water is 2. 2 % of the cPAD for the general U.S.

population and 11 % of the cPAD for childr en 1

- 2 years old, the most highly exposed population

subgroup

. The results of the chronic dietary exposure analysis are reported in the summary table

below

.

Table 4 . Summary of Dietary (Food and Drinking Water) Exposure and Risk for Abamectin

Population Subgroup Acute Dietary

99.9 th Percentile) Chronic Dietary

Dietary Exposure

(mg/kg/day) % aPAD* Dietary Exposure

(mg/kg/day) % cPAD*

General U.S. Population 0.001135 45 0.000056 2.2

All Infants (< 1 year old) 0.001584 63 0.000096 3.9

Children 1

- 2 years old* 0.002192 88 0.000268 11Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 14 of 60 Table 4 . Summary of Dietary (Food and Drinking Water) Exposure and Risk for Abamectin

Population Subgroup Acute Dietary

99.9 th Percentile) Chronic Dietary

Dietary Exposure

(mg/kg/day) % aPAD* Dietary Exposure

(mg/kg/day) % cPAD*

Children 3

- 5 years old 0.001553 62 0.000160 6.4

Children 6

- 12 years old 0.000729 29 0.000090 3.6

Youth 13

- 19 years old 0.000475 19 0.000045 1.8

Adults 20

- 49 years old 0.000446 18 0.000038 1.5

Adults 50

- 99 years old 0.000345 14 0.000037 1.5

Females 13

- 49 years old 0.000427 17 0.000038 1.5

* The subpopulation with the highest risk estimates is bolded.



### V II I

. Characterization of Inputs/Outputs

T he acute and chronic assessments are both refined assessments. A nticipated residues based on

field trials were used. Although field trial data provide more refined exposure estimates than

tolerances, the results may still be c onsidered somewhat conservative since field trials are

condu cted under maximum use conditions (maximum allowed application rate and number of

applications, minimum preharvest interval, etc.). No monitoring data were used. Additionally,

there are numerous non

- detects in the crop field trials with abamectin indicat ing low residues in

growing crops

. Residues in the dietary exposure assessment were adjusted for % CT and empirical

or default processing factors. A residue distribution file of water EDWCs was used for the acute

assessment. A point estimate EDWC was us ed for the chronic assessment. The acute critical

exposure contribution (CEC) analysis (Attachment 14) showed that milk is t he major contributor

of dietary exposure for children 1

- 2 years old

. The chronic critical commodity contribution

analysis (CCCA) showed that milk and meat of beef are the major contributors for the general US

population and milk is the major contributor of dietary exposure for children 1

- 2 years old

.

I X

. Conclusions

Refined acute and chronic dietary (food and drinking water) expos ure assessments were conducted

for all proposed and registered food uses of abamectin. A nticipated residues based on field trial

data were used

. Empirical and d efault processing factors and % CT were used

. EDWCs from

EFED were provided. A residue distribution file of water EDWCs was used for the acute

assessment. A point estimate EDWC was used for the chronic assessment.

The acute dietary exposure estimates for food and drinking water are not of concern (<100%

aPAD) at th e 99.9 th 

### percentile of exposure for the general U.S. populatio n and all population

subgroups

.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 15 of 60 

### The chronic dietary exposure estimates for food and drinking water are not of concern ( <100%

cPAD) for the general U.S. population and all population subgroups.

Because these analyses were conducted using conservative assumptions such as field trial data and

model

- derived EDWCs, HED is confident that the assessment does not underestimate risk to the

general U.S. populat ion or any population subgroup.

X. List of Attachments

Attachment 1: Anticipated Residues Summary Table for A ba mectin

Attachment 2: Acute Residue Distribution Files for A ba m ectin

Attachment 3: Acute Food plus Water Residue Input File

Attachment 4: Acute Food plus Water Results File

Attachment 5: Acute Food only Results File

Attachment 6 : Chronic Food plus Water Residue Input File

Attachme nt 7 : Chronic Food plus Water Results File

Attachment 8 : Acute Water Only Residue Input File

Attachment 9 : Acute Water Only Results File

Attachment 10 : Chronic W ater Only Residue Input File

Attachment 11 : Chronic Water Only Results File

Attachment 12 : BEAD Percent Crop Treated Data

Attachment 13: Calculation of Livestock Anticipated Residues

Attachment 14: Acute Critical Exposure Contribution AnalysisAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 16 of 60 

### Attachment 1: Anticipated Residues Summary Table for A ba mectin

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

Almond PB FT (D163057, MRID

4182250 1 ) 6/0 0.001 70 80 RDF 1 0.001*0. 70

=

0.000 70

Almond , oil B See Almond. 70 80 0.001 *0.80=

0.00080 0.001*0. 70

=

0.000 70

Amaranth, leafy PB See Spinach

. 100 100 RDF 45 0.044

Apple NB/PB FT

(D201328;D201333) 31/31 0.073 juice 0.002 10 30 RDF 2 0.0039*0.10

=

0.000 39

Apple, dried B See Apple. 8 .0 dried 10 30 0.0039 *0.30=

0.0012 0.0039*0. 10=

0.00039

Apricot NB/PB See Peach

. 6 .0 dried 15 30 RDF 31 0.0057*0. 1 5=0.

000 86

Arrowroot, flour B See Potato

. 100 100 0.0027 0.0027

Artichoke, Jerusalem NB See Potato

. 100 100 RDF 36 0.0027

Arugula PB See Spinach

. 100 100 RDF 45 0.044

Avocado NB FT (MRID 45083501) 10/10 0.001 35 60 RDF 4 0.0047*0. 35 =0.

001 6

Balsam pear NB See Cucumber

. 100 100 RDF 48 0.0022

Basil, fresh leaves B FT (MRID 45871901) 8/6 0.001 100 100 0.008 0.008

Basil, dried leaves B FT (MRID 45871901) 3/3 0.001 100 100 0.019 0.019

Bean, dry, seed B Tol ( D380795, MRID

48135003) 0.001 2.5 2.5 0. 004 1 *0.025=

0.0001 0 0.0 04 1 *0.025

=

0.0001 0

Bean, lima

, succulent PB FT ( D424008, MRID

49455904) 100 100 0.004 (HAFT) 0.004

Bean, snap

, succulent PB FT ( D424008, MRID

49455908) 100 100 0.004 (HAFT) 0.004

Beef, fat 6 PB Max Residue

(D414022) 0.001 45 57 RDF 24 0.038 *0. 45

=

0.0171Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 17 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

Beef, meat 6 PB Max Residue

(D414022) 1.92 dried 0.001 45 57 RDF 25 0.0084 *0. 45

=

0.0 0 1 8

Beef, meat

byproduct 6 PB Max Residue

(D414022) 0.001 45 57 RDF 26 0.076 *0. 45

=

0.03 42

Blackberry PB FT (D412860; MRID

49080101) 6/6 0.001 56 68 RDF 54 0.0293*0.56=

0.016

Blueberry, lowbush PB See Strawberry. 0.003 100 100 RDF 62 0.017

Boysenberry PB See Raspberry. 56 68 RDF 55 0.0445*0.56=0.

025

Brazil nut PB See Pecan. 100 100 RDF 52 0.005

Butter nuts PB See Pecan. 100 100 RD F 52 0.005

Cantaloupe NB/PB Cantaloupe FT

(D203373, MRID

43203801) 18/0 0.002 25 45 RDF 5 0.002*0.25=

0.00050

Cardoon NB See Celery. 100 100 RDF 7 0.014

Cashew PB See Pecan. 100 100 RDF 52 0.005

Cassava NB/PB See Potato. 100 100 RDF 36 0.0027

Celer iac NB FT (D268398; MRID

45079901) 8/4 0.002 100 100 0.017 0.0062

Celery NB/PB FT (D207554; MRID

45096102) 84/84 0.002 45 70 RDF 8 0.014* 0.4 5

=

0.0063

Celtuce NB See Celery

. 100 100 RDF 7 0.014

Chayote, fruit NB See Squash, summer

. 100 100 RDF 49 0.002

Cherry PB FT (MRID

45096707/45096708) 37/37 1.5 juice 0.001 5 20 RDF 29 0.016*0.0 5

=

0.00080

Chestnut PB See Almond. 100 100 RDF 51 0.001

Chinese waxgourd NB See Cucumber

. 100 100 RDF 48 0.0022

Chive, fresh leaves B Tol (D380795, MRID

48135002) 0.001 100 100 0.0041 0.0041

Chive, dried leaves B Tol (D380795, MRID

48135002 ) 2.9 dried 0.001 100 100 0.0041 0.0041Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 18 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

Chrysanthemum,

Garland PB See Spinach

. 100 100 RDF 45 0.044

Citrus citron and

Citrus hybrids NB See Orange

. 100 100 RDF 53 0.0041

Citrus, oil B See Orange

. 9.7 oil 100 100 0.0041 0.0041

Coconut PB /B/NB See Almond

. 2.1 dried 100 100 0.01 0.001

Corn, sweet, kernel

plus cob with husk

removed NB/PB

FT (D414022; MRID

49071008) 12/0 0.003 45 57 RDF 58 0.006*0.45=

0.0027

Cottonseed oil B FT (D 401832 ) 22/3 0.003 20 30 0.0070*0.30=

0.0021 0.00 70 *0. 20

=

0.0014

Crabapple NB See Apple. 0 .002 100 100 RDF 63 0.0039

Cranberry PB See Strawberry. 1.1 juice 0.003 100 100 RDF 62 0.017

Cress, garden PB See Spinach

. 100 100 RDF 45 0.044

Cress, upland PB See Spinach

. 100 100 RDF 45 0.044

Cucumber NB/PB FT (D203373, MRID

43203801) 8/1 0.002 5 10 RDF 46 0.0022*0.05=0.

00011

Dandelion, leaves PB See Spinach

. 100 100 RDF 45 0.044

Dasheen, corm NB See Potato

. 100 100 RDF 36 0.0027

Dillweed B See Basil, fresh leaves 100 100 0.008 0.008

Eggplant NB/PB See Bell pepper

. 100 100 RDF 9 0.0034

Endive PB See spinach. 100 100 RDF 45 0.044

Fennel, Florence NB See Celery

. 100 100 RDF 7 0.014

Garlic NB/PB Tol ( D380795, MRID

4813500 1 ) 0.001 100 100 0.0046 0.0040

Ginger NB/PB See Potato

. 100 1 00 RDF 36 0.0027Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 19 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

Ginge r, dried B See Potato

. 100 1 00 0.0027 0.0027

Goat, fat 6 PB Max Residue

(D414022) 0.001 45 57 RDF 39 0. 0 088 *0. 45

=

0. 0.0036

Goat, meat 6 PB Max Residue

(D414022) 0.001 45 57 RDF 6 5 0.0 02 7 *0.45

=

0. 00 1215

Goat, kidney 6 PB Max Residue

(D414022) 0.001 45 57 RDF38 0.0027*0.45=0.

001215

Goat, meat

byproducts (incl.

liver) 6 PB Max Residue

(D414022) 0.001 45 57 RDF 38 0.0 11 *0.45

=

0. 0 0495

Goji berry PB See Tomato FT. 0.002 100 100 RDF 47 0.0027

Gooseberry PB See Grape. 0.001 100 100 RDF 61 0.0023

Grape PB FT (MRID 44346001) 26/26 0.47 juice 0.001 15 35 RDF 12 0.0023*0.1 5

=

0.00034

Grape

, raisin PB See Grape. 0.75 0.001 15 35 RDF 13 0.0023*0.15=

0.00034

Grapefruit NB/PB FT (D207554) 6/6 0.85 juice 0.001 7 0 90 RDF 11 0.00125*0.70=

0.00088

Guava 4 NB/PB FT (D424008, MRID

49455903) 100 100 0.0050 (HAFT) 0.0043

Hazelnuts PB See Pecan FT.

(MRID 45096709) 22/22 2.5 2.5 RDF 28 0.005*0.025=

0.00012

Hazelnut, oil B See Hazelnuts. 2.5 2.5 0.005*0.025=

0.00012 0.005*0.025=

0.00012

Herbs, other B See Basil, fresh leaves 100 100 0.008 0.008

Hickory nut PB See Pecan

. 100 100 RDF 52 0.0 05Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 20 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

Honeydew NB/PB C antaloupe FT

(MRID 43203801) 18/0 0.002 20 35 RDF 37 0.002 x 0.20 =

0.00040

Horse, Sheep, meat 6 PB Max Residue

(D414022) 0.001 45 57 RDF 6 5 0.0024*0.45=0.

00108

Hop B FT (MRID 43733101) 10/10 0.001 100 100 0.051 0.051

Kumquat PB See Orange

. 100 100 RDF 53 0.0041

Lemon NB/PB FT (D207554) 4/4 0.25 juice

2.5 peel 0.001 40 55 RDF 33 0.00125*0. 40=

0.00050

Lemongrass B See Basil, fresh leaves 100 100 0.008 0.008

L ettuce, head NB FT (D207554, MRID

45096702) 22/22 0.002 2 0 45 RDF 14 0.0086 *0.2 0

=

0.00172

Lettuce, leaf PB FT (D254546, MRID

44708506) 12/12 0.002 2 0 45 RDF 42 0.023*0.2 0 =

0.0046

Lime PB See Lemon

. 0.25 juice 100 100 RDF 35 0.00125

Loganberry PB See Raspberry FT. 56 68 RDF 55 0.0445

Loquat NB See Pear. 0 .005 100 100 RDF 64 0.0074

Lychee 4 NB FT (D424008, MRID

49455905) 100 100 0.0027 (HAFT) 0.0024 (Mean)

Lychee, dried B FT (D424008, MRID

49455905) 1.85 dried 100 100 0.0024 (Mean) 0.0024

Macadamia nut PB See Pecan

. 100 100 RDF 52 0.0 05

Marjoram B See Basil, fresh leaves 100 100 0.008 0.008

Milk 6 PB Max Residue

(D414022) 0.001 45 57 RDF 16 0.011*0. 45

=

0.00 5 5

Nectarine NB See Peach

. 20 20 RDF 50 0.0057 *0.20=0.

0011

Okra NB/PB See Pepper, non

- bell. 0.002 100 100 0.006 0.004

Onion, bulb NB/PB FT (D380795, MRID

48135001) 0.001 2.5 10 RDF 59 0.0040*0.025=

0.00010Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 21 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

Onion, bulb , dried B See Onion, bulb. 9.0 dried 2.5 10 0.0040*0.10=

0.00040 0.0040*0.025=

0.00010

Onion, green,

subgroup 3

- 07B NB/ PB FT (D424008, MRID

49455902) 100 100 0.0046 (HAFT) 0.004

Orange NB/PB FT (D207554) 16/16 0.25 juice

2.5 peel 0.005 40 70 RDF 15 0.0041*0. 40

=

0.0016

Papaya 4 NB/PB FT (D424008, MRID

49455906) 1.5 juice 100 100 RDF 66 0.0863

Papaya, dried B FT (D424008, MRID

49455906) 1.8 dried 100 100 0.0863 (Mean) 0.0863

Parsley, leaves PB See Spinach 100 100 RDF 45 0.044

Parsley, dried l eaves B Basil FT (MRID

45871901) 3/3 0.001 100 100 0.019 0.019

Peach NB/PB FT (MRID

45096707/45096708) 27/27 0.001 10 25 RDF 30 0.0057*0.10=0.

00057

Peach, dried B See Peach. 7 .0 dried 0.001 10 25 0.0057*0.25=

0.0014 0.0057*0.10=

0.00057

Pear NB/PB FT (D207554) 8/8 0.005 70 85 RDF 17 0.0074*0.70=0.

0052

Pear , dried B See Pear. 6.25 dried 0.005 70 85 0.0074*0.85=

0.0063 0.0074*0.70=

0.0052

Pecan PB FT (MRID 45096709)

D316756 22/22 0.005 1 2.5 RDF 28 0.0 05 *0.01=

0.000 05 0

Pepper, bell NB/PB FT (D206550, MRID

43334601) 6/2 0.002 15 30 RDF 19 0.0034*0.15=

0.00051

Pepper, bell , dried B See Pepper, bell. 0.002 15 30 0.0034*0.30=

0.0010 0.0034*0.15=

0.00051

Pepper, non

- bell NB/PB FT (chili pepper)

(D238327, MRID

44300002) 8/4 0.002 15 30 RDF 41 0.0040 * 0.1 5

=

0.00060Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 22 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

Pepper, non

- bell

, Dried B See Pepper, non

- bell. 0.002 15 30 0.0040*0.30=

0.0012 0.0040 * 0.1 5

=

0.00060

Pepperm int B FT (MRID 45096706) 14/4 0.001 100 100 0.047 0.047

Pineapple NB/PB FT (D424008, MRID

49455907) 1.7 juice 100 100 0.004 (HAFT) 0.004 (Mean)

Pineapple, dried B FT (D424008, MRID

49455907) 5 dried 100 100 0.004 (Mean) 0.004 (Mean)

Pi ne nut PB See Almond

. 100 100 RDF 51 0.001

Pistachio PB See Almond

. 2.5 2.5 RD F 57 0.001 x 0.025

=0.000025

Plum (Prune) NB/PB FT (MRID 44708503) 30/9 5.0 dried

1.4 juice 0.001 10 35 RDF 18 0.0020*0. 10=0.

0002

Plum (Non

- prune) NB/PB FT (MRID 44708503) 30/9 5.0 dried

1.4 juice 0.001 100 100 RDF 56 0.0020* 1.00=0.

0020

Pork fat 6 PB Tol (D414022) 0.001 5 5 RDF 27 0.01*0.05 =

0.0005

Pork meat/mbypd 6 PB Tol (D414022) 0.001 5 5 RDF 40 0.02*0.05 =

0.001

Potato NB/PB FT (MRID 45096705) 15/15 0.002 5 20 RDF 20 0.0027*0.05=0.

00014

Potato, chips

Potato, dry

Potato, flour B See Potato. 6.5 dry

6.5 flour 0.002 5 20 0.0027*0.20=

0.00054 0.0027*0.05 =

0.00014

Poultry

meat/mbypd 5, 6 PB Tol (D414022) 0.001 5 5 RDF 40 0.02*0.05 =

0.001

Pummelo NB See grapefruit

. 100 100 RDF 10 0.00125

Pumpkin NB/PB Summer squash FT

(MRID 43203801) 8/0 0.001 5 10 RDF 3 0.002*0.05=

0.0001

Quince NB See Pear. 0 .005 100 100 RDF 64 0.0074

Radicchio NB See Lettuce, head

. 0.001 100 100 RDF 43 0.0086

Raspberry PB FT (D412860; MRID 8/8 0.001 56 68 RDF 55 0.0445*0.56=Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 23 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

49080101) 0.025

Rhubarb NB/PB See Celery

. 100 100 RDF 7 0.014

Savory B See Basil, fresh leaves 100 100 0.008 0.008

Shallot , bulb NB Tol ( D380795, MRID

4813500 1 ) 0.001 100 100 0.0046 0.0040

Sheep, fat 6 PB Max Residue

(D414022) 0.001 45 57 RDF 39 0.0168*0.45=

0.00756

Sheep, kidney 6 PB Max Residue

(D414022) 0.001 45 57 RDF 38 0.0060*0.45=

0.0027

Sheep, liver 6 PB Max Residue

(D414022) 0.001 45 57 RDF 38 0.024*0.45=

0.0108

Sheep, meat

byproducts 6 PB Max Residue

(D414022) 0.001 45 57 RDF 38 0.024*0.45=

0.0108

Soybean B FT (D414022; MRID

49071010) 20/0 0.001 8 11 0.006*0.11=

0.00066 0.006*0.08=

0.00048

Spearm int B FT (MRID 45096706) 14/4 0.001 100 100 0.047 0.047

Spinach PB FT (D254546, MRID

44708506) 12/12 0.002 25 45 RDF 44 0.044*0.25

=

0.011

Squash, summer NB/PB FT (MRID 43203801) 8/0 0.001 5 15 RDF 6 0.002 * 0.05=

0.00010

Squash, winter NB /PB See Squash, summer

. 5 15 RDF 6 0.002* 0.05=

0.00010

Strawberry PB FT (D401832) 12/12 0.003 30 45 RDF 21 0.017 *0.30

=

0.0051

Sweet potato NB/PB See Potato

. 100 100 RDF 36 0.0027

Swiss chard NB See Celery

. 100 100 RDF 7 0.014

Tangerine NB/PB FT Orange and

Tangelo (D207554) 20/6 0.25 juice 35 55 RDF 34 0.0035*0. 35=0.

0012

Tanier, corm NB See Potato

. 100 100 RDF 36 0.0027Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 24 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity 1 DEEM Food

Form/

(Classification 2 ) Data Source No. of

Samples/

No. of

Detectable

Residues Processing

Factors 1⁄2 LOD

(ppm) % CT Anticipated Residue

Estimates/Tolerance

Avg. Max. Acute

(Tol., AR,

RDF) Chronic 3

(Tol., AR)

Tomato,

Greenhouse

- grown NB/PB GH (D424008, MRID

49455901) 8/8 14.3 dried

0.21 juice

1.2 paste

0.40 puree 0.002 10 25 RDF 22 0.017(Mean)*0.

10=

0.0017

Tomato tree NB See T omato FT. 0.002 100 100 RDF 47 0.0027

Tomatillo NB/PB See T omato FT. 0.002 100 100 RDF 47 0.0027

Turmeric NB/PB See Potato

. 100 100 RDF 36 0.0027

Walnut PB FT (D163057, MRID

41822501) 6/0 0.001 25 55 RDF 23 0.001*0.25 =

0.00025

Watermelon NB/PB FT(Watermelon

+Cantaloupe)

(D203373, MRID

43203801) 22/0 0.001 5 15 RDF 32 0.002*0. 05

=

0.000 10

Yam , bean NB See Potato

. 100 100 RDF 36 0.00 27

Yam , true NB See Potato

. 100 100 RDF 36 0.00 27

1 Percent crop treated data were provided for tangelo s and pluots (plum/apricot hybrids) , but tangelo s and pluots were not included in this table because they

are not included in the DEEM.

2 M. Stasikowski, 8/20/99, Classification of Food Forms with Respect to Level of Blending. HED Standard Operating Procedure 99.6 ; and F. Fort, Draft

Revised Blending Classification.

3 In this chronic dietary assessment, no residue used was less than the food handling establishment (FHE) value (1/2 LOD = 0.002 ppm) x 5% CT for food in foo d

handli ng establishments (0.0002 x 0.05).

4 The c ommodity definitions for guava, lychee, and papaya are stated in EPA’s “Reviewer’s Guide and Summary of HED ChemSAC Approvals for

Amending Crop Groups/Subgroups [40 CFR § 180.41] and Commodity Definitions [40 CFR § 180.1(h)]” (Bernard Schneider, June 14, 2006). Accordi ng to that

document, guava includes g uava, feijoa, jaboticaba, wax ja mbu, s tarfruit, passionfruit, and acerola; lychee includes lychee, longan, Spanish lime, rambutan,

and p ulasan ; and papaya includes papaya, black sapote, canistel, mamey sapote, mango, sapodilla, and star apple. The petitioner is not requesting use on man go.

5 No tolerance has been established for poultry fat.

6 The %CT values that were used to refine livestock commodities were sweet corn forage for ruminants and food handling establishment uses for poultry and swine.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 25 of 60 

### Attachment 2: Acute Residue Distribution Files for A ba mectin and Chronic Point Estimate s

Table A.2. Acute Residue Distribution Files for Abamectin

R DF#1 Almond

'Almond 2008_ FT

80 %CT

TOTALZ=2

TOTALNZ=6

0.001 0.001 0.001 0.001

0.001 0.001 RDF#2 Apple

'Apple 2008_ FT

30 %CT

TOTALZ= 72

TOTALNZ=31

0.003 0.003 0.002 0.0079

0.0051 0.0041 0.0037 0.003

0.002 0.0039 0.003 0.0034

0.003 0.012 0.0091 0.002

0.002 0.0079 0.0055 0.0036

0.003 0.003 0.002 0.002

0.002 0.003 0.0047 0.003

0.0043 0.002 0.0038 RDF#3 Pumpkin

‘ Summer Squash FT

10 %CT

TOTALZ=72

TOTALNZ=8

0.002 0.002 0.002 0.002

0.002 0.002 0.002 0.002 RDF#4 Avocado

'Avocado FT

60%CT

TOTALZ=7

TOTALNZ=10

0.002 0.006 0.004 0.004

0.002 0.002 0.004 0.007

0.010 0.006

RDF#5 Cantaloupe

' C antaloupe FT 45 %CT

TOTALZ= 22

TOTALNZ= 18

18 , 0 .002 RDF#6 Summer s quash

' Sum m er s quash 2008_ FT

15 %CT

TOTALZ=45

TOTALNZ=8

8

, 0.002 RDF#7 Celer y 1

100%CT 'Celery FT

100%CT

TOTALZ=0

TOTALNZ=84

0.0121 0.0231 0.0082

0.0166 0.006 0.006 0.006

0.006 0.006 0.0074 0.0074

0.0089 0.006 0.006 0.006

0.006 0.006 0.0073 0.00125

0.006 0.0098 0.0105 0.0157

0.0208 0.0116 0.0076

0.0088 0.092 0.006 0.0082

0.0066 0.0067 0.0406

0.0097 0.0175 0.0097

0.0095 0.0088 0.0089 0.006

0.006 0.006 0.006 0.006

0.006 0.006 0.006 0.006

0.006 0.007 0.00111 0.0341

0.0083 0.021 0.0082 0.0093

0.0092 0.006 0.0192 0.0121

0.0198 0.0281 0.0281

0.0292 0.0205 0.0231

0.0105 0.0098 0.0132

0.0135 0.0066 0.0074 0.012

0 .0128 0.0085 0.0083

0.0066 0.0234 0.0091

0.0067 0.0101 0.0106 0.148

0.06 RDF#8 Celery

'Celery FT

70 %CT

TOTALZ=36

TOTALNZ=84

0 .0121 0.0231 0.0082

0.0166 0.006 0.006 0.006

0.006 0.006 0.0074 0.0074

0.0089 0.006 0.006 0.006

0.006 0.006 0.0073 0.00125

0.006 0.0098 0.0105 0.0157

0.0208 0.0116 0.0076

0.0088 0.092 0.006 0.0082

0.0066 0.0067 0.0406

0.0097 0.0175 0.0097

0.0095 0.0088 0.0089 0.006

0.006 0.006 0.006 0.006

0.006 0.006 0.006 0.006

0.006 0. 007 0.00111 0.0341

0.0083 0.021 0.0082 0.0093

0.0092 0.006 0.0192 0.0121

0.0198 0.0281 0.0281

0.0292 0.0205 0.0231

0.0105 0.0098 0.0132

0.0135 0.0066 0.0074 0.012

0.0128 0.0085 0.0083

0.0066 0.0234 0.0091

0.0067 0.0101 0.0106 0.148

0.06Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 26 of 60 Table A.2. Acute Residue Distribution Files for Abamectin

RDF#9 Eggplant

'Pepper, bell FT

100%CT

TOTALZ=0

TOTALNZ=6

0.00125

0.00125

0.00125

0.00125

0.00938

0.00600 RDF#10 Grapefruit 2

100%CT

'Grapefruit FT

100%CT

TOTALZ=0

TOTALNZ=6

0.00125

0.00125

0.00125

0.00125

0.00125

0.00125 RDF#11 Grapefruit

'Grapefruit FT

90%CT

TOTALZ=1

TOTALNZ=6

0.00125

0.00125

0.00125

0.00125

0.00125

0.00125 RDF#12 Grape

'Grape FT

35%CT

TOTALZ=48

TOTALNZ=26

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.0060 0.0077

0.0037 0.0040 0.0053

0.0063 0.0034

RDF#13 Grape

- raisin

'Grape

- raisin FT 35%CT

TOTALZ=48

TOTALNZ=26

19, 0.00125 0.0060 0.0077

0.0037 0.0040 0.0053

0.0063 0.0034 RDF#14 Lettuce, head

'Lettuce, head FT

45%CT

TOTALZ=27

TOTALNZ=22

0.0346 0.0335 0.0063

0.0076 0.00125 0.00125

0.00125 0.00125 0.0302

0.0259 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.0066 0.0265

0.00125 0.00125 0.00125

0.00125 RDF#15 Orange

'Orange FT

70%CT

TOTALZ=7

TOTALNZ=16

0.00125 0.00125 0.00125

0.00125 0.0091 0.0088

0.006 0.006 0.0111 0.0122

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125 RDF#16 Milk

'Milk FT data

'57%CT from sweet corn

cannery waste'

TOTALZ=43

TOTALFREQ=1

57, 0.011

RDF#17 Pear

'Pear FT

8 5 %CT

TOTALZ=1

TOTALNZ=8

0.0044 0.0039 0.0053

0.0064 0.0061 0.0109

0.0126 0.0098 RDF#18 P lum (prune)

'Plum (p rune ) FT

35 %CT

TOTALZ= 56

TOTALNZ=30

0.001 0.001 0.001 0.001

0.001 0.001 0.001 0.001

0.001 0.001 0.001 0.001

0.001 0.001 0.001 0.001

0.001 0.001 0.001 0.001

0.001 0.001 0.0065 0.0045

0.0035 0.0035 0.0035

0.0055 0.0055 0.0055 RDF#19 Pepper , bell

'Pepper,bell FT

30 %CT

TOTALZ=14

TOTALNZ=6

0.00125

0.00125

0.00125

0.00125

0.00938

0.00600 RDF#20 Potato

'Potato FT

20 %CT

TOT ALZ=60

TOTALNZ=15

0.003 0.003 0.003 0.003

0.003 0.003 0.003 0.003

0.003 0.003 0.003 0.002

0.002 0.002 0.002

RDF#21 Strawberry

'Strawberry FT

45%CT

TOTALZ= 15

TOTALNZ= 12

0.013 0.011 0.016 0.012

0.013 0.019 0.025 0.022

0.022 0.028 0.008 0.013 RDF#22 Tomato _GH 3

‘GH Tomato

25% CT

TOTALZ=24

TOTALNZ=8

0.02476 0.04120 0.01864

0.01549 0.01216 0.01021

0.00684 0.00587 RDF#23 Walnut

'Walnut FT

'55 % CT

TOTALZ=5

TOT AL NZ=6

0.001 0.001 0.001 0.001

0.001 0.001 RDF#24 Beet

- fat

'Beef fat

' 57 %CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57 , 0.038Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 27 of 60 Table A.2. Acute Residue Distribution Files for Abamectin

RDF#25 Beef meat

57 %CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57 , 0.0084 RDF#26 Beef

- mbypd

'Beef mbypd

57 %CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57 , 0.076 RDF#27 Hog fat 4

‘Hog fat

5%CT from FHE

TOTALZ=95

TOTALFREQ=1

5, 0.01 RDF#28 Pecan

'Pecan FT

'2.5%CT

TOTALZ=858

TOTALNZ=22

22, 0.01

RDF#29 Cherry

'Cherry FT

20%CT

TOTALZ=148

TOTALNZ=37

0.009 0.011 0.009 0.013

0.005 0.005 0.006 0.008

0.006 0.006 0.005 0.02

0.017 0.016 0.015 0.009

0.009 0.022 0.016 0.016

0.065 0.04 0.028 0.032 0.015

0.031 0.025 0.026 0.012

0.012 0.009 0.009 0.007

0.017 0.006 0.009 0.009 RDF#30 Peach

'Peach FT

25%CT

TOTALZ=81

TOTALNZ=27

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.005

0.007 0.007 0.007 0.005

0.009 0.011 0.026 RDF#31 Apricot

'Peach FT

30%CT

TOTALZ=63

TOTALNZ=27

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.005

0.007 0.007 0.007 0.005

0.009 0.011 0.026 RDF#32 Watermelon

‘Watermelon + Cantaloupe

FT 15%CT

TOTALZ=125

TOTALNZ=22

22, 0.002

RDF#33 Lemon

'Lemon FT

55%CT

TOTALZ=3

TOTALNZ=4

0.00125

0.00125

0.00125

0.00125 RDF#34 Tangerine

'Orange + Tangelo FT

55%CT

TOTALZ=16

TOTALNZ=20

0.00125 0.00125 0.00125

0.00125 0.0091 0.0088

0.006 0.006 0.0111 0.0122

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 RDF#35 Lemon 100%CT

'Lemon FT

100%CT

TOTALZ=0

TOTALNZ=4

0.00125

0.00125

0.00125

0.00125 RDF#36 Subgroup 1C 5

'Potato FT

100%CT

TOTALZ=0

TOTALNZ=15

0.003 0.003 0.003 0.003

0.003 0.003 0.003 0.003

0.003 0.003 0.003 0.002

0.002 0.002 0.002

RDF#37 Honeydew

‘Cantaloupe FT

35%CT

TOTALZ=33

TOTALNZ=18

18, 0.002 RDF#38 Goat, Horse, Sheep

mbypd

‘Goat, Horse, Sheep mbypd

57 %CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57 , 0.024 RDF#39 Goat, Horse, Sheep

Fat

57 %CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57 , 0.0168 RDF#40 Hog, Poultry meat

and mbypd 4

, 6

‘Hog, Poultry m, mbypd;

tolerance

5%CT from FHE

TOTALZ=95

TOTALFREQ=1

5, 0.02

RDF#41 Pepper, chili

'Chili Pepper FT

30%CT

TOTALZ=19

TOTALNZ=8

0.002 0.002 0.002 0.002

0.006 0.006 0.006 0.006 RDF#42 Lettuce,leaf

'Lettuce.leaf FT

45%CT

TOTALZ=15

TOTALNZ=12

0.016 0.017 0.007 0.010

0.061 0.046 0.013 0.023

0.020 0.017 0.020 0.027 RDF#43 Radicchio

'Lettuce,head FT

100%CT

TOTALZ=0

TOTALNZ=22

0.0346 0.0335 0.0063

0.0076 0.00125 0.00125

0.00125 0.00125 0.0302

0.0259 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.0066 0.0265

0.00125 0.00125 0.00125

0.00125 RDF#44 Spinach

Spinach FT

45%CT

TOTALZ=15

TOTALNZ=12

0.0285 0.0305 0.099 0.086

0.022 0.027 0.052 0.043

0.023 0.019 0.046 0.048Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 28 of 60 Table A.2. Acute Residue Distribution Files for Abamectin

RDF#45 Spinach 7

'Spinach FT

100%CT

TOTALZ=0

TOTALNZ=12

0.0285 0.0305 0.099 0.086

0.022 0.027 0.052 0.043

0.023 0.019 0.046 0.048 RDF#46 Cucumber

'Cucumber FT

10%CT

TOTALZ=72

TOTALNZ=8

0.036 0.002 0.002 0.002

0.002 0.002 0.002 0.002 RDF#47 Tomato 100%CT 8

'Tomato FT

100%CT

TOTALZ=0

TOTALNZ=45

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00 125 0.00125

0.00125 0.00125 0.00125

0.0064 0.006 0.006 0.006

0.006 0.0262 0.006 0.0077

0.006 RDF#48 Cucumber 100%

CT 9

'Cucumber FT

100%CT

TOTALZ=0

TOTALNZ=8

0.036 0.002 0.002 0.002

0.002 0.002 0.002 0.002

RDF#49 Squash 100% CT 10

'Summer squash FT

100%CT

TOTALZ=0

TOTALNZ=8

0.002 0.002 0.002 0.002

0.002 0.002 0.002 0.002 RDF#50 Nectarine

'Peach FT

20%CT

TOTALZ=108

TOTALNZ=27

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.004

0.004 0.004 0.004 0.004

0.004 0.004 0 .004 0.004

0.004 0.004 0.004 0.005

0.007 0.007 0.007 0.005

0.009 0.011 0.026 RDF#51 Almond 100%CT 1 1

'Almond FT

100%CT

TOTALZ=0

TOTALNZ=6

0.001 0.001 0.001 0.001

0.001 0.001 RDF#52 Pecan 100%CT 1 2

'Pecan FT

100%CT

TOTALZ=0

TOTALNZ=22

0.01 0.01 0.01 0.01 0.01

0.01 0.01 0.01 0.01 0.01

0.01 0.01 0.01 0.01 0.01

0.01 0.01 0.01 0.01 0.01

0.01 0.01

RDF#53 Orange 100%CT 1 3

'Orange FT

100%CT

TOTALZ=0

TOTALNZ=16

0.00125 0.00125 0.00125

0.00125 0.0091 0.0088

0.006 0.006 0.0111 0.0122

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125 RDF#54 Blackberry

Blackberry FT

68%CT

TOTALZ=4

TOTALNZ=8

0.0632

0.0438

0.0236

0.0171

0.0178

0.0164

0.0265

0.0258 RDF#55 Raspberry 1 4

'Raspberry FT

68%CT

TOTALZ=3

TOTALNZ=6

0.0076

0.0091

0. 0072

0.0062

0.1215

0.1152 RDF#56 Plum (non

- prune)

'Plum(non

- prune)FT

100%CT

TOTALZ=0

TOTALNZ=30

0.001 0.001 0.001 0.001

0.001 0.001 0.001 0.001

0.001 0.001 0.001 0.001

0.001 0.001 0.001 0.001

0.001 0.001 0.001 0.001

0.001 0.001 0.0065 0.0045

0.0035 0.0035 0.0035

0.0055 0.0055 0.0055

RDF#57 Pistachio

'Almond2008_FT

2.5%CT

TOTALZ=234

TOTALNZ=6

0.001 0.001 0.001 0.001

0.001 0.001 RDF#58 Sweet Corn

‘Sweet Corn_FT

57%CT

TOTALZ=9

TOTALNZ=12

0.006 0.006 0.006 0.006

0.006 0.006 0.006 0.006

0.006 0.006 0.006 0.006 RDF#59 Onion

, Bulb

‘Onion Bulb_FT

10% CT

TOTALZ=72

TOTALNZ=8

0.0043 0.0040 0.0040

0.0040 0.0040 0.0040

0.0040 0.0040 RDF#60 Drinking Water

Soybean Drinking WaterAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 29 of 60 Table A.2. Acute Residue Distribution Files for Abamectin

RDF#61 Gooseberry

'Grape FT

100%CT

TOTALZ=0

TOTALNZ=26

.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.0060 0.0077

0.0037 0.0040 0.0053

0.0063 0.0034 RDF#62 Strawberry

100%CT 1 5

'Strawberry FT

100%CT

TOTALZ=0

TOTALNZ=12

0.013 0.011 0.016 0.012

0.013 0.019 0.025 0.022

0.022 0.028 0.008 0.013 RDF#63 Apple100%CT 1 6

'Apple2008_FT

100%CT

TOTALZ=0

TOTALNZ=31

0.003 0.003 0.002 0.0079

0.0051 0.0041 0.0037 0.003

0.002 0.0039 0.003 0.0034

0.003 0.012 0.0091 0.002

0.002 0.0079 0.0055 0.0036

0.003 0.003 0.002 0.002

0.002 0.003 0.0047 0.003

0.0043 0.002 0.0038 RDF#64 Pear100%CT 1 7

'Pear FT

100%CT

TOTALZ=0

TOTALNZ=8

0.0044 0.0039 0.0053

0.0064 0.0061 0.0109

0.0126 0.0098

RDF#65: Goat, Horse,

Sheep Meat

‘Goat, Horse, Sheep Meat

57 %CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57, 0.0024 RDF #66 Papaya

100%CT

TOTALZ=0

TOTALNZ=3

0.0051

0.131

0.123

1 RDF u sed for celtuce, cardoon, fennel, rhubarb, and Swiss chard

.

2 RDF u sed for pummelo

.

3 RDF#22 contains only greenhouse

- grown tomato data; RDF #22 was used for all tomatoes since greenhouse data

were higher than field

- grown tomato data

.

4 The residues in hog and poultry commodities fr om consuming treated feed are considerably less than the current

tolerances from the food handling establishment use. Therefore, the percent food tr eated of 5% was used in the

residue data files for poultry and hog commodities.

5 RDF u sed for Tanier, corm; turmeric; ginger; artichoke; yam, bean; yam, true; sweet potato; cassava; dasheem, corm.

6

. RDF#40 was used for hog meat/mbypd and poultry meat/mbypd.

7 RDF u sed for parsley, garden cress, upland cress, chrysanthemum garland, amaranth, parsley leaves, dandelion

leaves, endive

.

8 RDF u sed for tree tomato, tomatillo, goji berry

.

9 RDF u sed for chinese waxgourd, balsam pear

.

10 RDF used for chayote.

1 1 RDF used for pine nut, chestnut.

1 2 RDF used for brazil nut, butter nut, cashew, hickory nut, mac adamia.

1 3 RDF used for kumquat, citron, citrus hybrids.

1 4 RDF used for raspberry, boysenberry, loganberry.

1 5 RDF used for cranberry.

1 6 RDF used for crabapple.

1 7 RDF used for loquat.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 30 of 60 

### Attachment 3 : Acute Food plus Water Residue Input File

Filename: C: \ Users \ KRURY \ Documents \ My Work Files \ Abamectin \ Dietary Files \ Abamectin acute

Food and Water PRIA 3 29 16.R08

Chemical: Avermectin

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/d ay

Date created/last modified: 03

- 29

- 2016/12:31:57 Program ver. 3.16, 03

- 08

- d

Comment: Food and Water at 0.76 ppb; Updated 3/23/16

----------------------------------------------------------------------------------- RDL indices and parameters for Mont e Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

----- ---- ------------ -------- -------- -------

1 6 Almond2008_FT.RDF

2 6 Apple2008_FT.RDF

3 6 Pumpkin2008_FT.RDF

4 6 Avocado2008.RDF

5 6 Cantaloupe2008_FT.RDF

6 6 Summer squash2008_FT.RDF

7 6 Celery 100%CT_FT.RDF

8 6 Celery2008_FT.RDF

9 6 Eggplant2008.RDF

10 6 Grapefruit100%CT_FT.RDF

11 6 Grapefruit2008_FT.RDF

1 2 6 Grapes2008.RDF

13 6 Grape

- raisin2008.RDF

14 6 Lettuce,head 2008_FT.RDF

15 6 Orange2008_FT.RDF

16 6 Milk2016_FT_57.RDF

17 6 Pear2008_FT.RDF

18 6 Plum (prune)2008.RDF

19 6 Pepper,bell2008_FT.RDF

20 6 Po tato2008_FT.RDF

21 6 Strawberry2012.RDF

22 6 Tomato_GH.RDF

23 6 Walnut2008.RDF

24 6 Beef

- fat57CT.RDF

25 6 Beef, sheep, goat meat_FT.RDF

26 6 Beef

- mbyp2008_FT.RDF

27 6 Hog

- fat_FHE.RDF

28 6 Pecan2008.RDF

29 6 Cherry2008.RDF

30 6 Peach2008.RDF

31 6 Apricot2008.RDF

32 6 Watermelon_FT.RDF

33 6 Lemon2008_FT.RDF

34 6 Tangerine2008_FT.RDF

35 6 Lemon100%CT_FT.RDF

36 6 Potato2008100CT_FT.RDF

37 6 Honeydew.RDF

38 6 Goat, Horse, Sheep mbypd.RDF

39 6 Goat, Horse, Sheep Fat.RDF

40 6 Hog, Poultry m, mbypd.RDF

41 6 Pepper, Chili 2008_FT.RDF

42 6 Lettuce,leaf2008_FT.RDF

43 6 Radicchio.RDF

44 6 Spinach _FT.RDF

45 6 Spinach 100%_FT.RDF

46 6 Cucumber_FT.RDF

47 6 Tomato100%CT.RDF

48 6 Cucumber100%CT_FT.RDF

49 6 Summer squash100%CT_FT.RDF

50 6 Nectarine.RDF

51 6 Almond 100%CT.RDFAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 31 of 60 52 6 Pecan 100%CT.RDF

53 6 Orange100%CTFT.RDF

54 6 Blackberry.RDF

55 6 Raspberry.RDF

56 6 Plum (nonprune)2008.RDF

57 6 Pistachio.RDF

58 6 Sweet Corn.RDF

59 6 Onion Bulb.RDF

60 6 Aba_MSsoyb_MSsoybeanSTD_Reservoir_Parent_DEEM.rdf

61 6 Grape100%CT.RDF

62 6 Strawberry100%CT.RDF

63 6 Apple100%CT.RDF

64 6 Pear100%CT.RDF

65 6 GHS Meat.RDF

66 6 Papaya2015100CT_FT.RDF

EPA Crop Commodity Name Def Res Adj.Factors RDLComment

Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

0101084000 1AB Celeriac 0.017000 1.000 1.000 D26839

Full comment: D268398, 45079901.der

0103015000 1CD Arrowroot, flour 0.002700 1.000 1.000 Blende

Full comment: Blended

0103015001 1CD Arrowroot, flour

- babyfood 0.002700 1.000 1.000 Blende

Full comment: Blended

0103017000 1CD A rtichoke, Jerusalem 0.010000 1.000 1.000 36

0103082000 1CD Cassava 0.010000 1.000 1.000 36

0103082001 1CD Cassava

- babyfood 0.010000 1.000 1.000 36

0103139000 1CD Dasheen, corm 0.010000 1.000 1.000 36

0103166000 1CD Ginger 0.010000 1.000 1.000 36

0103166001 1CD Ginger

- babyfood 0.010000 1.000 1.000 36

0103167000 1CD Ginger, dried 0.002700 1.000 1.000 Blende

Full comment: Blended

0103296000 1C Potato, chips 0.002700 1.000 0.200 Blende

Full comment: Blended

0103297000 1C Potato, dry (granules/ flakes) 0.002700 6.500 0.200 Blende

Full comment: Blended

0103297001 1C Potato, dry (granules/ flakes)

- b 0.002700 6.500 0.200 Blende

Full comment: Blended

0103298000 1C Potato, flour 0.002700 6.500 0.200 Blende

Full com ment: Blended

0103298001 1C Potato, flour

- babyfood 0.002700 6.500 0.200 Blende

Full comment: Blended

0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 20 FT (MR

Full comment: FT (MRID 45096705)

01032 99001 1C Potato, tuber, w/peel

- babyfood 0.010000 1.000 1.000 20

0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 20

0103300001 1C Potato, tuber, w/o peel

- babyfood 0.010000 1.000 1.000 20

0103366000 1CD Sw eet potato 0.010000 1.000 1.000 36

0103366001 1CD Sweet potato

- babyfood 0.010000 1.000 1.000 36

0103371000 1CD Tanier, corm 0.010000 1.000 1.000 36

0103387000 1CD Turmeric 0.010000 1.000 1.000 36

0103406000 1CD Yam, true 0.010000 1.000 1.000 36

0103407000 1CD Yam bean 0.010000 1.000 1.000 36

0301165000 3A Garlic, bulb 0.004600 1.000 1.000 D38079

Full comment: D380795, MRID 48135001

0301165001 3A Garlic, bulb

- babyfood 0.004600 1.000 1.000 D38079

Full comment: D380795, MRID 48135001

0301237000 3A Onion, bulb 0.004600 1.000 1.000 59 D38079

Full comment: D380795, MRID 48135001

0301237001 3A Onion, bulb

- babyfood 0.004600 1.000 1.000 59 D38079

Full comment: D380795, MRID 48135001

0301238000 3A Onion, bulb, dried 0.004000 9.000 0.100 Blende

Full comment: Blended

0301238001 3A Onion, bulb, dried

- babyfood 0.004000 9.000 0.100 BlendeAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 32 of 60 Full comment: Blended

0301338000 3A Shallot, bulb 0.004600 1.000 1.000 D38079

Full comment: D380795, MRID 48135001

0302103000 3B Chive, fresh leaves 0.004600 1.000 1.000 D38079

Full comment: D380795, MRID 48135002

0302198000 3B Leek 0.004600 1.000 1.000

0302239000 3B Onion, green 0.004600 1.000 1.000 D42400

Full comment: D424008, MRID 49455902

0302338500 3B Shallot, fresh leaves 0.004600 1.000 1.000

0401005000 4A Amaranth, leafy 0.100000 1.000 1.000 45

0401018000 4A Arugula 0.100000 1.000 1.000 45

0401104000 4A Chrysanthemum, garland 0.100000 1.000 1.000 45

0401133000 4A Cress, garden 0. 100000 1.000 1.000 45

0401134000 4A Cress, upland 0.100000 1.000 1.000 45

0401138000 4A Dandelion, leaves 0.100000 1.000 1.000 45

0401150000 4A Endive 0.100000 1.00 0 1.000 45

0401204000 4A Lettuce, head 0.100000 1.000 1.000 14 FT (D2

Full comment: FT (D207554, MRID 45096702)

0401205000 4A Lettuce, leaf 0.100000 1.000 1.000 42 FT (D2

Full comment: FT (D254546, 44708506)

0401248000 4A Parsley, leaves 0.100000 1.000 1.000 45 Spinac

Full comment: Spinach FT (D254546, MRID 44708506)

0401313000 4A Radicchio 0.100000 1.000 1.000 43

0401355000 4A Spinach 0.100000 1.000 1.000 44 FT (D2

Full comment: FT (D254546, MRID 44708506)

0401355001 4A Spinach

- babyfood 0.100000 1.000 1.000 44

0402076000 4B Cardoon 0.100 000 1.000 1.000 7

0402085000 4B Celery 0.100000 1.000 1.000 8 FT (D

Full comment: FT (D207554, MRID 45096102)

0402085001 4B Celery

- babyfood 0.100000 1.000 1.000 8

0402086000 4B Celery, juice 0.100000 1.000 1.000 8

0402087000 4B Celtuce 0.100000 1.000 1.000 7

0402152000 4B Fennel, Florence 0.100000 1.000 1.000 7

0402322000 4B Rhubarb 0.100000 1.000 1.000 7

0402367000 4B Swiss chard 0.100000 1.000 1.000 7

0600347000 6 Soybean, seed 0.006000 1.000 0.110 Blende

Full comment: Bl ended FT D414022, MRID 49071010

0600349000 6 Soybean, soy milk 0.006000 1.000 0.110 FT D41

Full comment: FT D414022, MRID 49071010

0600349001 6 Soybean, soy milk

- babyfood or in 0.006000 1.000 0.110 FT D41

Fu ll comment: FT D414022, MRID 49071010

0600350000 6 Soybean, oil 0.006000 1.000 0.110 FT D41

Full comment: FT D414022, MRID 49071010

0600350001 6 Soybean, oil

- babyfood 0.006000 1.000 0.110 FT D41

Full comment: FT D414022, MRID 49071010

0601043000 6A Bean, snap, succulent 0.004000 1.000 1.000

0601043001 6A Bean, snap, succulent

- babyfood 0.004000 1.000 1.000

0601349500 6AB Soybean, vegetable 0.006000 1.000 0.110 FT D41

Full comment: FT D414022, MRID 49071010

0602031000 6B Bean, broad, succulent 0.004000 1.000 1.000

0602033000 6B Bean, cowpea, succulent 0.004000 1.000 1.000

0602037000 6B Bean, lima, succulent 0.004000 1.000 1.000

0603030000 6C Bean, black, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603032000 6C Bean, broad, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603034000 6C Bean, cowpea, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603035000 6C Bean, great northern, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603036000 6C Bean, kidney, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603038000 6C Bean, lima, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603039000 6C Bean, mung, seed 0.004100 1.000 0.025 D38079Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 33 of 60 Full comment: D380795, MRID 48135003

0603040000 6C Bean, navy, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603041000 6C Bean, pink, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603042000 6C Bean, pinto, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603098000 6C Chickpea, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603098001 6C Chickpea, seed

- babyfood 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603099000 6C Chickpea, flour 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603182000 6C Guar, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603182001 6C Guar, seed

- babyfood 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603348000 6C Soybean, flour 0.006000 1.000 0.110 D41402

Full comment: D414022, MRID 49071010

0603348001 6C Soybean, flour

- babyfood 0.006000 1.000 0.110 D41402

Full comment: D414022, MRID 49071010

0801374000 8A Tomatillo 0.016000 1.000 1.000 47

0801375000 8A Tomato 0.033000 1.000 1.000 22 FT (D2

Full comment: FT (D207554, MRID 45096703)

0801375001 8A Tomato

- babyfood 0.033000 1.000 1.000 22

0801376000 8A Tomato, paste 0.033000 1.200 1.000 22

0801376001 8A Tomato, paste

- babyfood 0.033000 1.200 1.000 22

0801377000 8A Tomato, puree 0.03 3000 0.400 1.000 22

0801377001 8A Tomato, puree

- babyfood 0.033000 0.400 1.000 22

0801378000 8A Tomato, dried 0.017000 14.300 1.000 Blende

Full comment: Blended

0801378001 8A Tomato, dried

- babyfo od 0.017000 14.300 1.000 Blende

Full comment: Blended

0801379000 8A Tomato, juice 0.033000 0.210 1.000 22

0801380000 8A Tomato, Tree 0.016000 1.000 1.000 47

0802148000 8BC E ggplant 0.020000 1.000 1.000 9

0802234000 8BC Okra 0.006000 1.000 1.000 D23832

Full comment: D238327, MRID 44300002

0802270000 8B Pepper, bell 0.020000 1. 000 1.000 19 FT (D2

Full comment: FT (D206550, MRID 43334601)

0802270001 8B Pepper, bell

- babyfood 0.020000 1.000 1.000 19

0802271000 8B Pepper, bell, dried 0.003400 1.000 0.300 Blende

Full comment: B lended

0802271001 8B Pepper, bell, dried

- babyfood 0.003400 1.000 0.300 Blende

Full comment: Blended

0802272000 8BC Pepper, nonbell 0.020000 1.000 1.000 41 FT (D2

Full comment: FT (D238327, MRID 44300002)

080 2272001 8BC Pepper, nonbell

- babyfood 0.020000 1.000 1.000 41

0802273000 8BC Pepper, nonbell, dried 0.004000 1.000 0.300 Blende

Full comment: Blended

0901075000 9A Cantaloupe 0.005000 1.000 1.000 5 FT (D2

Full comment: FT (D203373, MRID 43203801)

0901187000 9A Honeydew melon 0.005000 1.000 1.000 37

0901399000 9A Watermelon 0.005000 1.000 1.000 32 FT (D2

Full comment: FT (D203373, MRID 43203801)

0901400000 9A Watermelon, juice 0.005000 1.000 1.000 32

0902021000 9B Balsam pear 0.005000 1.000 1.000 48

0902088000 9B Chayote, fruit 0.005000 1.0 00 1.000 49

0902102000 9B Chinese waxgourd 0.005000 1.000 1.000 48

0902135000 9B Cucumber 0.005000 1.000 1.000 46 FT (D2

Full comment: FT (D203373, MRID 43203801)

0902308000 9B Pumpkin 0.005000 1.000 1.000 3

0902309000 9B Pumpkin, seed 0.005000 1.000 1.000 3

0902356000 9B Squash, summer 0.005000 1.000 1.000 6 FT (MR

Full comment: FT (MRID 432038 01)Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 34 of 60 0902356001 9B Squash, summer

- babyfood 0.005000 1.000 1.000 6

0902357000 9B Squash, winter 0.005000 1.000 1.000 6

0902357001 9B Squash, winter

- babyfood 0.005000 1.000 1.000 6

100110600 0 10A Citron 0.020000 1.000 1.000 53

1001107000 10A Citrus hybrids 0.020000 1.000 1.000 53

1001108000 10A Citrus, oil 0.004100 9.700 1.000 Blende

Full comment : Blended

1001240000 10A Orange 0.020000 1.000 1.000 15 FT (D2

Full comment: FT (D207554)

1001241000 10A Orange, juice 0.020000 0.250 1.000 15

1001241001 10A Orange, juice

- babyfood 0.020000 0.250 1.000 15

1001242000 10A Orange, peel 0.020000 2.500 1.000 15

1001369000 10A Tangerine 0.020000 1.000 1.000 34 FT (D2

Full comment: FT (D207554)

1001370000 10A Tangerine, juice 0.020000 0.250 1.000 34

1002197000 10B Kumquat 0.020000 1.000 1.000 53

1002199000 10B Lemon 0.020000 1.000 1.000 33 FT (D2

Ful l comment: FT (D207554)

1002200000 10B Lemon, juice 0.020000 0.250 1.000 33

1002200001 10B Lemon, juice

- babyfood 0.020000 0.250 1.000 33

1002201000 10B Lemon, peel 0.020000 2.500 1 .000 33

1002206000 10B Lime 0.020000 1.000 1.000 35

1002207000 10B Lime, juice 0.020000 0.250 1.000 35

1002207001 10B Lime, juice

- babyfood 0.020000 0.250 1.000 35

10 03180000 10C Grapefruit 0.020000 1.000 1.000 11 FT (D2

Full comment: FT (D207554)

1003181000 10C Grapefruit, juice 0.020000 0.850 1.000 11

1003307000 10C Pummelo 0.020000 1.000 1.000 10

1100007000 11 Apple, fruit with peel 0.020000 1.000 1.000 2 FT (D

Full comment: FT (D201328, D201333)

1100008000 11 Apple, peeled fruit 0.020000 1.000 1.000 2

1100008001 11 Apple, pe eled fruit

- babyfood 0.020000 1.000 1.000 2

1100009000 11 Apple, dried 0.003900 8.000 0.300 Blende

Full comment: Blended

1100009001 11 Apple, dried

- babyfood 0.003900 8.000 0.300 Blende

Full comment: Blended

1100010000 11 Apple, juice 0.020000 0.073 1.000 2

1100010001 11 Apple, juice

- babyfood 0.020000 0.073 1.000 2

1100011000 11 Apple, sauce 0.020000 1.000 1.000 2

1100011001 11 Apple, sauce

- babyfood 0.020000 1.000 1.000 2

1100129000 11 Crabapple 0.020000 1.000 1.000 63

1100173500 11 Goji berry 0.016000 1.000 1.000 47

1100210000 11 Loquat 0.020000 1.000 1.000 64

1100266000 11 Pear 0.020000 1.000 1.000 17 FT (D2

Full comment: FT (D207554)

1100266001 11 Pear

- babyfood 0.0200 00 1.000 1.000 17

1100267000 11 Pear, dried 0.007400 6.250 0.850 Blende

Full comment: Blended

1100268000 11 Pear, juice 0.020000 1.000 1.000 17

1100268001 11 Pear, juice

- babyfood 0.020000 1.000 1.000 17

1100310000 11 Quince 0.020000 1.000 1.000 64

1201090000 12A Cherry 0.090000 1.000 1.000 29 FT (MR

Full comment: FT (MRID 450967

- 07,

- 08)

12 01090001 12A Cherry

- babyfood 0.090000 1.000 1.000 29

1201091000 12A Cherry, juice 0.090000 1.500 1.000 29

1201091001 12A Cherry, juice

- babyfood 0.090000 1.500 1.000 29

1202012000 12B Apricot 0.090000 1.000 1.000 31

1202012001 12B Apricot

- babyfood 0.090000 1.000 1.000 31

1202013000 12B Apricot, dried 0.090000 6.000 1.000 31

1202014000 12B Apricot, jui ce 0.090000 1.000 1.000 31

1202014001 12B Apricot, juice

- babyfood 0.090000 1.000 1.000 31

1202230000 12B Nectarine 0.090000 1.000 1.000 50

1202260000 12B Peach 0.090000 1.000 1.000 30 FT (MR

Full comment: FT (MRID 450967

- 07,

- 08)

1202260001 12B Peach

- babyfood 0.090000 1.000 1.000 30Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 35 of 60 1202261000 12B Peach, dried 0.005700 7.000 0.250 Blende

Full comment: Blended

1202261001 12B Peach, dried

- babyfood 0.005700 7.000 0.250 Blende

Full comment: Blended

1202262000 12B Peach, juice 0.090000 1.000 1.000 30

1202262001 12B Peach, juice

- babyfo od 0.090000 1.000 1.000 30

1203285000 12C Plum 0.090000 1.000 1.000 56 FT (MR

Full comment: FT (MRID 44708503)

1203285001 12C Plum

- babyfood 0.090000 1.000 1.000 56

1203286000 12C Plum, prune, fresh 0.090000 1.000 1.000 18 FT (MR

Full comment: FT (MRID 44708503)

1203286001 12C Plum, prune, fresh

- babyfood 0.090000 1.000 1.000 18

1203287000 12C Plum, prune, dried 0.090000 5.000 1.000 18

1203287001 12C Plum, prune, dried

- babyfood 0.090000 5.000 1.000 18

1203288000 12C Plum, prune, juice 0.090000 1.400 1.000 18

1203288001 12C Plum, prune, juice

- babyfood 0.090000 1. 400 1.000 18

1301055000 13A Blackberry 0.200000 1.000 1.000 54 D41286

Full comment: D412860, MRID 49080101

1301056000 13A Blackberry, juice 0.200000 1.000 1.000 54

1301056001 13A Blackberry, ju ice

- babyfood 0.200000 1.000 1.000 54

1301058000 13A Boysenberry 0.200000 1.000 1.000 55

1301208000 13A Loganberry 0.200000 1.000 1.000 55

1301320000 13A Raspberry 0.200000 1.000 1.000 55 D41286

Full comment: D412860, MRID 49080101

1301320001 13A Raspberry

- babyfood 0.200000 1.000 1.000 55

1301321000 13A Raspberry, juice 0.200000 1.000 1.000 55

130132100 1 13A Raspberry, juice

- babyfood 0.200000 1.000 1.000 55

1302057000 13B Blueberry 0.020000 1.000 1.000 62 13

- 07G

1302057001 13B Blueberry

- babyfood 0.020000 1.000 1.000 62

1302174000 13B Gooseberry 0.020000 1.000 1.000 61 13

- 07F

1304175000 13D Grape 0.020000 1.000 1.000 12 FT (MR

Full comment: FT (MRID 44346001) 13

- 07F

1304176000 13D Grape, juice 0.0 20000 0.470 1.000 12

1304176001 13D Grape, juice

- babyfood 0.020000 0.470 1.000 12

1304179000 13D Grape, wine and sherry 0.020000 1.000 1.000 12

1307130000 13G Cranberry 0.020000 1.000 1.000 62 13

- 07G

1307130001 13G Cranberry

- babyfood 0.020000 1.000 1.000 62

1307131000 13G Cranberry, dried 0.020000 1.000 1.000 62

1307132000 13G Cranberry, juice 0.020000 1.100 1.000 62

1307132001 13G Cranberry, juice

- babyfood 0.020000 1.100 1.000 62

1307359000 13G Strawberry 0.020000 1.000 1.000 21 FT D4

Full comment: FT D401832 13

- 07G

1307359001 13G Strawberry

- babyfood 0.020000 1.000 1.000 21

1307360000 13G Strawberry, juice 0.020000 1.000 1.000 21

1307360001 13G Strawberry, juice

- babyfood 0.020000 1.000 1.000 21

1400003000 14 Almond 0.010 000 1.000 1.000 1 FT (D1

Full comment: FT (D163057, MRID 41822501)

1400003001 14 Almond

- babyfood 0.010000 1.000 1.000 1

1400004000 14 Almond, oil 0.001000 1.000 0.800 Blende

Full co mment: Blended

1400004001 14 Almond, oil

- babyfood 0.001000 1.000 0.800 Blende

Full comment: Blended

1400059000 14 Brazil nut 0.010000 1.000 1.000 52

1400068000 14 Butternut 0.010000 1.000 1.000 52

1400081000 14 Cashew 0.010000 1.000 1.000 52

1400092000 14 Chestnut 0.010000 1.000 1.000 51

1400155000 14 Hazelnut 0.010000 1.000 1.000 28 D31675

Full comment: D316756, MRID 45096709

1400156000 14 Hazelnut, oil 0.005000 1.000 0.025 Blende

Full comment: Blended

1400185000 14 Hickory nut 0.010000 1.000 1.000 52

1400213000 14 Macadamia nut 0.010000 1.000 1.000 52

1400269000 14 Pecan 0.010000 1.000 1.000 28 FT (MR

Full comment: FT (MRID 45096709)

1400278000 14 Pine nut 0.010000 1.000 1.000 51Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 36 of 60 1400282000 14 Pistachio 0.010000 1.000 1.000 57

1400391000 14 Walnut 0.010000 1.000 1.000 23 FT (D1

Ful l comment: FT (D163057, MRID 41822501)

1500127000 15 Corn, sweet 0.006000 1.000 1.000 58 FT D41

Full comment: FT D414022, MRID 49071008

1500127001 15 Corn, sweet

- babyfood 0.006000 1.000 1.000 58 FT D41

Full comment: FT D414022, MRID 49071008

1901028000 19A Basil, fresh leaves 0.008000 1.000 1.000 FT (MR

Full comment: FT (MRID 45871901)

1901028001 19A Basil, fresh leaves

- babyfood 0.008000 1.000 1.000

190102 9000 19A Basil, dried leaves 0.019000 1.000 1.000 FT (MR

Full comment: FT (MRID 45871901)

1901029001 19A Basil, dried leaves

- babyfood 0.019000 1.000 1.000

1901102500 19A Chive, dried leaves 0.0041 00 2.900 1.000 D38079

Full comment: D380795, MRID 48135002

1901118000 19A Cilantro, leaves 0.008000 1.000 1.000

1901118001 19A Cilantro, leaves

- babyfood 0.008000 1.000 1.000

1901144000 19A Dillwee d 0.008000 1.000 1.000

1901184000 19A Herbs, other 0.008000 1.000 1.000

1901184001 19A Herbs, other

- babyfood 0.008000 1.000 1.000

1901202000 19A Lemongrass 0.008000 1.000 1.000

1901220000 19A Marjoram 0.008000 1.000 1.000

1901220001 19A Marjoram

- babyfood 0.008000 1.000 1.000

1901249000 19A Parsley, dried leaves 0.019000 1.000 1.000 Basil

Full comment: Basil FT (MRID 45871901)

1901249001 19A Parsley, dried leaves

- babyfood 0.019000 1.000 1.000

1901334000 19A Savory 0.008000 1.000 1.000

2003114001 20 C Coconut, oil

- babyfood 0.010000 1.000 1.000

2003128000 20C Cottonseed, oil 0.007000 1.000 0.300 FT (D4

Full comment: FT (D401832) Blended

2003128001 20C Cottonseed, oil

- babyfood 0.007000 1.000 0.300 FT (D4

Full comment: FT (D401832) Blended

3100044000 31 Beef, meat 0.008400 1.000 1.000 25 D34480

Full comment: D344808

3100044001 31 Beef, meat

- babyfood 0.008400 1.000 1.000 25

3100045000 31 Beef, meat, dried 0.008400 1.920 1.000 25

3100046000 31 Beef, meat byproducts 0.076000 1.000 1.000 26 D34480

Full comment: D344808

3100046001 31 Beef, meat byproducts

- babyfood 0.076000 1.000 1.000 26

3100047000 31 Beef, fat 0.038000 1.000 1.000 24 D34480

Full comment: D344808

3100047001 31 Beef, fat

- babyfood 0.038000 1.000 1.000 24

3100048000 31 Beef, kidney 0.026000 1.000 1.000 26

3100049000 31 Beef, liver 0.076000 1.000 1.000 26

3100049001 31 Beef, liver

- babyfood 0.076000 1.000 1.000 26

3200169000 32 Goat, meat 0.0 02400 1.000 1.000 65 D34480

Full comment: D344808

3200170000 32 Goat, meat byproducts 0.024000 1.000 1.000 38

3200171000 32 Goat, fat 0.017000 1.000 1.000 39

3200172000 32 Goat, kidney 0.006000 1.000 1.000 38

3200173000 32 Goat, liver 0.024000 1.000 1.000 38

3300189000 33 Horse, meat 0.002400 1.000 1.000 65 D34480

Full comment: D344808

3400290000 34 Pork, meat 0.020000 1.000 1.000 40 D34480

Full comment: D344808

3400290001 34 Pork, meat

- babyfood 0.020000 1.000 1.000 40

3400291000 34 Pork, skin 0.020000 1.000 1.000 40

3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000 40

3400292001 34 Pork, meat byproducts

- babyfood 0.020000 1.000 1.000 40

3400293000 34 Pork, fat 0.010000 1.000 1.000 27

3400293001 34 Pork, fat

- babyfood 0.010000 1.000 1.000 27

3400294000 34 Pork, kidney 0.020000 1.000 1.000 40

3400295000 34 Pork, liver 0.020000 1.000 1.000 40

3500339000 35 Sheep, meat 0.002400 1.000 1.000 65 D34480

Full comment: D344808Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 37 of 60 3500339001 35 Sheep, meat

- babyfood 0.002400 1.000 1.000 65

3500340000 35 Sheep, meat byproducts 0.024000 1.000 1.000 38

3500341000 35 Sheep, fat 0.017000 1.000 1.000 39

3500341001 35 Sheep, fat

- babyfood 0.017000 1.000 1.000 39

3500342000 35 Sheep, kidney 0.006000 1.000 1.000 38

3500343 000 35 Sheep, liver 0.024000 1.000 1.000 38

3600222000 36 Milk, fat 0.011000 1.000 1.000 16 D34480

Full comment: D344808

3600222001 36 Milk, fat

- baby food/infant formu 0.011000 1.000 1.000 16

3600223000 36 Milk, nonfat solids 0.011000 1.000 1.000 16

3600223001 36 Milk, nonfat solids

- baby food/in 0.011000 1.000 1.000 16

3600224000 36 Milk, water 0.011000 1.000 1.000 16

3 600224001 36 Milk, water

- babyfood/infant form 0.011000 1.000 1.000 16

3600225001 36 Milk, sugar (lactose)

- baby food/ 0.011000 1.000 1.000 16

4000093000 40 Chicken, meat 0.020000 1.000 1.000 40 D34480

Full comment: D344808

4000093001 40 Chicken, meat

- babyfood 0.020000 1.000 1.000 40

4000094000 40 Chicken, liver 0.020000 1.000 1.000 40

4000095000 40 Chicken, meat byproducts 0.020000 1.000 1.000 40

4000095001 40 Chicken, meat byproducts

- babyfoo 0.020000 1.000 1.000 40

4000097000 40 Chicken, skin 0.020000 1.000 1.000 40

4000097001 40 Chicken, skin

- babyfood 0.020000 1.000 1.000 40

5000382000 50 Turkey, meat 0.020000 1.000 1.000 40 D34480

Full comment: D344808

5000382001 50 Turkey, meat

- babyfood 0.020000 1.000 1.000 40

5000383000 50 Turkey, liver 0.020000 1.000 1.000 40

5000383001 50 Turkey, liver

- babyfood 0.020000 1.000 1.000 40

5000384000 50 Turkey, meat byproducts 0.020000 1.000 1.000 40

5000384001 50 Turkey, meat byproducts

- babyfood 0.020000 1.000 1.000 40

5000386000 50 Turkey, skin 0.020000 1.000 1.000 40

5000386001 50 Turkey, skin

- babyfood 0.020000 1.000 1.000 40

6000301000 60 Poultry, other, meat 0.020000 1.000 1.000 40 D34480

Full comment: D344808

6000302000 60 Poultry, other, liver 0.020000 1.000 1.000 40

6000303000 60 Poultry, other, meat byproducts 0.020000 1.000 1.000 40

6000305000 60 Poultry, other, skin 0.020000 1.000 1.000 40

8601000000 86A Water, direct, all sources 0.000760 1.000 1.000 60

8602000000 86B Water, indirect, all sources 0.000760 1.000 1.000 60

9500001000 O Acerola 0.005000 1.000 1.000 D4 2400

Full comment: D424008

9500020000 O Avocado 0.020000 1.000 1.000 4 FT (MR

Full comment: FT (MRID 45083501)

9500074000 O Canistel 0.131000 1.000 1.000

9500111000 O Coco nut, meat 0.010000 1.000 1.000

9500111001 O Coconut, meat

- babyfood 0.010000 1.000 1.000

9500112000 O Coconut, dried 0.010000 2.100 1.000 Defaul

Full comment: Default P F

9500113000 O Coconut, milk 0.010000 1.000 1.000

9500114000 O Coconut, oil 0.010000 1.000 1.000

9500151000 O Feijoa 0.005000 1.000 1.000 D42400

Full comment: D424008

9500177000 O Grape, leaves 0.020000 1.000 1.000 12

9500178000 O Grape, raisin 0.020000 0.750 1.000 13 MRID 4

Full comment: MRID 44346001

9500183000 O Guava 0.005000 1.000 1.000 D42400

Full comment: D424008, MRID 49455903

9500183001 O Guava

- babyfood 0.005000 1.000 1.000

9500188000 O Hop 0.051000 1.000 1.000 FT (MR

Full comment: FT (MRID 43733101)

9500209000 O Longan 0.002700 1.000 1.000

9500211000 O Lychee 0.002700 1.000 1.000 D42400

Full comment: D424008, MRID 49455905

9500212000 O Lychee, dried 0.002400 1.850 1.000 Blende

Full comment: Blended

9500245000 O Papaya 0.131000 1.000 1.000 66 D42400Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 38 of 60 Full comment: D424008, MRID 49455906

9500245001 O Papaya

- babyfood 0.131000 1.000 1.000 66

9500246000 O Papaya, dried 0.086300 1.800 1.000 Blende

Full comment: Blended

9500247000 O Papaya, juice 0.131000 1.500 1.000 6 6

9500252000 O Passionfruit 0.005000 1.000 1.000 D42400

Full comment: D424008

9500252001 O Passionfruit

- babyfood 0.005000 1.000 1.000

9500253000 O Passionfruit, juice 0.00500 0 1.000 1.000

9500253001 O Passionfruit, juice

- babyfood 0.005000 1.000 1.000

9500275000 O Peppermint 0.047000 1.000 1.000 FT (MR

Full comment: FT (MRID 45096706)

9500276000 O Peppermint, oil 0.047000 1.000 1.000

9500279000 O Pineapple 0.004000 1.000 1.000

9500279001 O Pineapple

- babyfood 0.004000 1.000 1.000

9500280000 O Pineapple, dried 0.004000 5.000 1.000 Blende

Full comment: Blended

9500281000 O Pineapple, juice 0.004000 1.700 1.000

9500281001 O Pineapple, juice

- babyfood 0.004000 1.700 1.000

9500333000 O Sapote , Mamey 0.131000 1.000 1.000 D42400

Full comment: D424008

9500351000 O Spanish lime 0.002700 1.000 1.000 D42400

Full comment: D424008

9500352000 O Spearmint 0 .047000 1.000 1.000 FT (MR

Full comment: FT (MRID 45096706)

9500353000 O Spearmint, oil 0.047000 1.000 1.000

9500358000 O Starfruit 0.005000 1.000 1.000 D42400

Full comment : D424008Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 39 of 60 

### Attachment 4 : Acute Food plus Water Result s File

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for AVERMECTIN NHANES 2003

- 2008 2

- Day

Residue file: Abamectin acute Food and Water PRIA 3 29 16.R08

Adjustment factor #2 used.

Analysis Date: 03

- 29

- 2016/12:38:49 Residue file dated: 03

- 29

- 2016/12:31:57

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Commen t: "Food and Water at 0.76 ppb; Updated 3/23/16"

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.000228 9.11 0.000548 21.90 0.001135 45.39

All Infants: 0.000391 15.63 0.001077 43.07 0.001584 63.37

**Children 1**

**- 2:**  **0.000959 38.38 0.001402 56.09 0.002192 87.68**

Children 3

- 5: 0.000554 22.15 0.000789 31.56 0.001553 62.10

Children 6

- 12: 0.000341 13.65 0.000497 19.87 0.000729 29.15

Youth 13

- 19: 0.000173 6.93 0.000286 11.43 0.000475 18.99

Adults 20

- 49: 0.000132 5.27 0.000219 8.78 0.000446 17.83

Adults 50

- 99: 0.000122 4.87 0.000199 7.96 0.000345 13.78

Female 13

- 49: 0.000134 5.37 0.000229 9.16 0.000427 17.10



### Attachment 5: Acute Food Only Results File

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysi s for AVERMECTIN NHANES 2003

- 2008 2

- Day

Residue file: Abamectin acute Food only PRIA 3 29 16.R08

Adjustment factor #2 used.

Analysis Date: 03

- 29

- 2016/13:07:16 Residue file dated: 03

- 29

- 2016/13:00:48

RAC/FF intake summed over 24 ho urs

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: "Food only; Updated 3/29/16"

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.000225 8.99 0.000544 21.77 0.001131 45.25

All Infants: 0.000378 15.11 0.001070 42.80 0.001581 63.23

**Children 1**

**- 2:**  **0.000955 38.19 0.001395 55.82 0.002188 87.53**

Children 3

- 5: 0.000549 21.97 0.000784 31.36 0.001558 62.32

Children 6

- 12: 0.000339 13.57 0.000494 19.76 0.000725 29.01

Youth 13

- 19: 0.000171 6.84 0.000284 11.36 0.000471 18.84

Adults 20

- 49: 0.000128 5.13 0.000216 8.63 0.000446 17.84

Adults 50

- 99: 0.000119 4.74 0.000196 7.83 0.000340 13.61

Female 13

- 49: 0.000131 5.23 0.000226 9.03 0.000427 17.06Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 40 of 60 

### Attachment 6 : Chronic Food plus Water Residue Input File

Filename: C: \ Users \ KRURY \ Documents \ My Work Files \ Ab amectin \ Dietary Files \ Abamectin chronic

PRIA 3 29 16.R08

Chemical: Avermectin

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 03

- 29

- 2016/09:11:57 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.000200 1.000 0.050 FHE =

Full comment: FHE = Food Handling Establishment

0101050001 1AB Beet, garden, roots

- babyfood 0.000200 1.000 0.050 FHE

0101052000 1A Beet, sugar 0.000200 1.000 0.050 FHE

0101052001 1A Beet, sugar

- babyfood 0.000200 1.000 0.050 FHE

0101053000 1A Beet, sugar, molasses 0.000200 1.000 0.050 FHE

0101053001 1A Beet, sugar, molasses

- babyfood 0.000200 1.000 0.050 FHE

0101067000 1AB Burdock 0.000200 1.000 0.050 FHE

0101078000 1AB Carrot 0.000200 1.000 0.050 FHE

0101078001 1AB Carrot

- babyfood 0.000200 1.000 0.050 FHE

0101079000 1AB Carrot, juice 0.000200 1.000 0.050 FHE

0101084000 1AB Celeriac 0.006200 1.000 1.000

0101100000 1AB Chicory, roots 0.000200 1.000 0.050 FHE

0101168000 1AB Ginseng, dried 0.000200 1.000 0.050 FHE

0101190000 1AB Horseradish 0.000200 1.000 0.050 FHE

0101250000 1AB Parsley, turnip rooted 0.000200 1.000 0.050 FHE

0101251000 1AB Parsnip 0.000200 1.000 0.050 FHE

0101251001 1AB Parsnip

- babyfood 0.000200 1.000 0.050 FHE

0101314000 1AB Radish, roots 0.000200 1.000 0.050 FHE

0101316000 1AB Radish, Oriental, roots 0.000200 1.000 0.050 FHE

0101327000 1AB Rutabaga 0.000200 1.000 0.050 FHE

0101331000 1AB Salsify, roots 0.000200 1.000 0.050 FHE

0101388000 1AB Turnip, roots 0.000200 1.000 0.050 FHE

0103015000 1CD Arrowroot, flour 0.002700 1.000 1.000

0103015001 1CD Arrowroot, flour

- babyfood 0.002700 1.000 1.000

0103017000 1CD Artichoke, Jerusalem 0.002700 1.000 1.000

0103082000 1CD Cassava 0.002700 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.002700 1.000 1.000

0103139000 1CD Dasheen, corm 0.002700 1.000 1.000

0103166000 1CD Ginger 0.002700 1.000 1.000

0103166001 1CD Ginger

- babyfood 0.002700 1.000 1.000

0103167000 1CD Ginger, dried 0.002700 1.000 1.000

0103296000 1C Potato, chips 0.002700 1.000 0.050 FT

0103297000 1C Potato, dry (granules/ flakes) 0.002700 6.500 0.050 FT

0103297001 1C Potato, dry (granules/ flakes)

- b 0.002700 6.500 0.050 FT

0103298000 1C Potato, flour 0.002700 6.500 0.050 FT

0103298001 1C Potato, flour

- babyfood 0.002700 6.500 0.050 FT

0103299000 1C Potato, tuber, w/peel 0.00270 0 1.000 0.050 FT

0103299001 1C Potato, tuber, w/peel

- babyfood 0.002700 1.000 0.050 FT

0103300000 1C Potato, tuber, w/o peel 0.002700 1.000 0.050 FT

0103300001 1C Potato, tuber, w/o peel

- babyfood 0.002700 1.000 0.050 F T

0103366000 1CD Sweet potato 0.002700 1.000 1.000

0103366001 1CD Sweet potato

- babyfood 0.002700 1.000 1.000

0103371000 1CD Tanier, corm 0.002700 1.000 1.000

0103387000 1CD Turmeri c 0.002700 1.000 1.000

0103406000 1CD Yam, true 0.002700 1.000 1.000

0103407000 1CD Yam bean 0.002700 1.000 1.000

0200051000 2 Beet, garden, tops 0.000200 1.000 0.050 FHE

0200101000 2 Chicory, tops 0.000200 1.000 0.050 FHE

0200140000 2 Dasheen, leaves 0.000200 1.000 0.050 FHE

0200315000 2 Radish, tops 0.000200 1. 000 0.050 FHE

0200317000 2 Radish, Oriental, tops 0.000200 1.000 0.050 FHEAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 41 of 60 0200332000 2 Salsify, tops 0.000200 1.000 0.050 FHE

0301165000 3A Garlic, bulb 0.004000 1.000 1.000 D380 79

Full comment: D380795, MRID 48135001

0301165001 3A Garlic, bulb

- babyfood 0.004000 1.000 1.000 D38079

Full comment: D380795, MRID 48135001

0301237000 3A Onion, bulb 0.004000 1.000 0.0 25 D38079

Full comment: D380795, MRID 48135001

0301237001 3A Onion, bulb

- babyfood 0.004000 1.000 0.025 D38079

Full comment: D380795, MRID 48135001

0301238000 3A Onion, bulb, dried 0.004000 9.000 0.025 D38079

Full comment: D380795, MRID 48135001

0301238001 3A Onion, bulb, dried

- babyfood 0.004000 9.000 0.025 D38079

Full comment: D380795, MRID 48135001

0301338000 3A Shallot, bulb 0.0 04000 1.000 1.000 D38079

Full comment: D380795, MRID 48135001

0302103000 3B Chive, fresh leaves 0.004000 1.000 1.000 D38079

Full comment: D380795, MRID 48135002, fresh

0302198000 3B Leek 0.004000 1.000 1.000

0302239000 3B Onion, green 0.004000 1.000 1.000 D42400

Full comment: D424008, MRID 49455902

0302338500 3B Shallot, fresh leaves 0.004000 1.000 1.000

040100500 0 4A Amaranth, leafy 0.044000 1.000 1.000

0401018000 4A Arugula 0.044000 1.000 1.000

0401104000 4A Chrysanthemum, garland 0.044000 1.000 1.000

0401133000 4A Cress, garden 0.044000 1.000 1.000

0401134000 4A Cress, upland 0.044000 1.000 1.000

0401138000 4A Dandelion, leaves 0.044000 1.000 1.000

0401150000 4A Endive 0.044000 1.000 1.000

0401204000 4A Lettuce, head 0.008600 1.000 0.200

0401205000 4A Lettuce, leaf 0.023000 1.000 0.200

0401248000 4A Parsley, leaves 0.044000 1.000 1.000

0401313 000 4A Radicchio 0.008600 1.000 1.000

0401355000 4A Spinach 0.044000 1.000 0.250

0401355001 4A Spinach

- babyfood 0.044000 1.000 0.250

0402076000 4B Cardoon 0.014000 1.000 1.000

0402085000 4B Celery 0.014000 1.000 0.450 FT

0402085001 4B Celery

- babyfood 0.014000 1.000 0.450

0402086000 4B Celery, juice 0.01 4000 1.000 0.450

0402087000 4B Celtuce 0.014000 1.000 1.000

0402152000 4B Fennel, Florence 0.014000 1.000 1.000

0402322000 4B Rhubarb 0.014000 1.000 1.000

0402367000 4B Swiss chard 0.014000 1.000 1.000

0501061000 5A Broccoli 0.000200 1.000 0.050 FHE

0501061001 5A Broccoli

- babyfood 0.000200 1.000 0.050 FHE

0501062000 5A Bro ccoli, Chinese 0.000200 1.000 0.050 FHE

0501064000 5A Brussels sprouts 0.000200 1.000 0.050 FHE

0501069000 5A Cabbage 0.000200 1.000 0.050 FHE

0501071000 5A Cabbage, Chinese, n apa 0.000200 1.000 0.050 FHE

0501072000 5A Cabbage, Chinese, mustard 0.000200 1.000 0.050 FHE

0501083000 5A Cauliflower 0.000200 1.000 0.050 FHE

0501196000 5A Kohlrabi 0.000200 1.000 0.050 FHE

0502063000 5B Broccoli raab 0.000200 1.000 0.050 FHE

0502070000 5B Cabbage, Chinese, bok choy 0.000200 1.000 0.050 FHE

0502117000 5B Collards 0.000200 1.000 0.050 FHE

0502194000 5B Kale 0.000200 1.000 0.050 FHE

0502229000 5B Mustard greens 0.000200 1.000 0.050 FHE

0502318000 5B Rape greens 0.000200 1.000 0.050 FHE

050 2389000 5B Turnip, greens 0.000200 1.000 0.050 FHE

0600347000 6 Soybean, seed 0.006000 1.000 0.080 FT MRI

Full comment: FT MRID 49071010

0600349000 6 Soybean, soy milk 0. 006000 1.000 0.080 FT MRI

Full comment: FT MRID 49071010

0600349001 6 Soybean, soy milk

- babyfood or in 0.006000 1.000 0.080 FT MRI

Full comment: FT MRID 49071010

0600350000 6 Soybean, oil 0.0060 00 1.000 0.080 FT MRIAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 42 of 60 Full comment: FT MRID 49071010

0600350001 6 Soybean, oil

- babyfood 0.006000 1.000 0.080 FT MRI

Full comment: FT MRID 49071010

0601043000 6A Bean, snap, succulent 0.004000 1.000 1.000 D38079

Full comment: D380795, MRID 48135008

0601043001 6A Bean, snap, succulent

- babyfood 0.004000 1.000 1.000 D38079

Full comment: D380795, MRID 48135008

0601257000 6A Pea, edible podded, succulent 0. 000200 1.000 0.050 FHE

0601349500 6AB Soybean, vegetable 0.006000 1.000 0.080 FT MRI

Full comment: FT MRID 49071010

0602031000 6B Bean, broad, succulent 0.004000 1.000 1.000 D42400

Full com ment: D424008

0602033000 6B Bean, cowpea, succulent 0.004000 1.000 1.000 D42400

Full comment: D424008

0602037000 6B Bean, lima, succulent 0.004000 1.000 1.000 D42400

Full comment: D424008, MRID 49 455904

0602255000 6B Pea, succulent 0.000200 1.000 0.050 FHE

0602255001 6B Pea, succulent

- babyfood 0.000200 1.000 0.050 FHE

0602259000 6B Pea, pigeon, succulent 0.000200 1.000 0.050 FHE

060303000 0 6C Bean, black, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48134003

0603032000 6C Bean, broad, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0 603034000 6C Bean, cowpea, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603035000 6C Bean, great northern, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48 135003

0603036000 6C Bean, kidney, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603038000 6C Bean, lima, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603039000 6C Bean, mung, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603040000 6C Bean, navy, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603041000 6C Bean, pink, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603042000 6C Bean, pinto, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603098000 6C Chickpea, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603098001 6C Chickpea, seed

- babyfood 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603099000 6C Chickpea, flour 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603182000 6C Guar, seed 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603182001 6C Guar, seed

- babyfood 0.004100 1.000 0.025 D38079

Full comment: D380795, MRID 48135003

0603203000 6C Lentil, seed 0.000200 1.000 0.050 FHE

0603256000 6C Pea, dry 0.000200 1.000 0.050 FHE

0603256001 6C Pea, dry

- babyfood 0.000200 1.000 0.050 FHE

0603258000 6C Pea, pigeon, seed 0.000200 1.000 0.050 FHE

0603348000 6C Soybean, flour 0.006000 1.000 0.080 FT MRI

Full comment: FT MRID 49071010

0603348001 6C Soybean, flour

- babyfood 0.006000 1.000 0.080 FT MRI

Full comment: FT MRID 49071010

0801374000 8A Tomatillo 0.002700 1.000 1.000 Tomato

Full comment: Tomato FT

0801375000 8A Tomato 0.017000 1.000 0.100 Greenh

Full comment: Greenhouse

0801375001 8A Tomato

- babyfood 0.017000 1.000 0.100

0801376000 8A Tomato, paste 0.017000 1.200 0.100

0801376001 8A Tomato, paste

- babyfood 0.017000 1.200 0.100

0801377000 8A Tomato, p uree 0.017000 0.400 0.100Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 43 of 60 0801377001 8A Tomato, puree

- babyfood 0.017000 0.400 0.100

0801378000 8A Tomato, dried 0.017000 14.300 0.100

0801378001 8A Tomato, dried

- babyfood 0.017000 14.300 0.100

0801379000 8A Tomato, juice 0.017000 0.210 0.100

0801380000 8A Tomato, Tree 0.002700 1.000 1.000 Tomato

Full comment: Tomato FT

0802148000 8BC Eggplant 0.003400 1.000 1.000

0802234000 8BC Okra 0.004000 1.000 1.000

0802270000 8B Pepper, bell 0.003400 1.000 0.150 FT

0802270001 8B Pepper, bell

- babyfood 0.003 400 1.000 0.150

0802271000 8B Pepper, bell, dried 0.003400 1.000 0.150

0802271001 8B Pepper, bell, dried

- babyfood 0.003400 1.000 0.150

0802272000 8BC Pepper, nonbell 0.004000 1.000 0.150 FT

08 02272001 8BC Pepper, nonbell

- babyfood 0.004000 1.000 0.150

0802273000 8BC Pepper, nonbell, dried 0.004000 1.000 0.150

0901075000 9A Cantaloupe 0.002000 1.000 0.250 D20337

Full comm ent: D203373, MRID 43203801

0901187000 9A Honeydew melon 0.002000 1.000 0.200

0901399000 9A Watermelon 0.002000 1.000 0.050 FT

0901400000 9A Watermelon, juice 0.002000 1.000 0.0 50 FT

0902021000 9B Balsam pear 0.002200 1.000 1.000

0902088000 9B Chayote, fruit 0.002000 1.000 1.000

0902102000 9B Chinese waxgourd 0.002200 1.000 1.000

0902135000 9B Cu cumber 0.002200 1.000 0.050 FT

0902308000 9B Pumpkin 0.002000 1.000 0.050

0902309000 9B Pumpkin, seed 0.002000 1.000 0.050

0902356000 9B Squash, summer 0.002000 1.000 0.050 FT

0902356001 9B Squash, summer

- babyfood 0.002000 1.000 0.050

0902357000 9B Squash, winter 0.002000 1.000 0.050

0902357001 9B Squash, winter

- babyfood 0.002000 1. 000 0.050

1001106000 10A Citron 0.004100 1.000 1.000

1001107000 10A Citrus hybrids 0.004100 1.000 1.000

1001108000 10A Citrus, oil 0.004100 9.700 1.000 D20755

Full comment: D207554

1001240000 10A Orange 0.004100 1.000 0.400

1001241000 10A Orange, juice 0.004100 0.250 0.400 D20755

Full comment: D207554

1001241001 10A Orange, juice

- baby food 0.004100 0.250 0.400

1001242000 10A Orange, peel 0.004100 2.500 0.400 D20755

Full comment: D207554

1001369000 10A Tangerine 0.003500 1.000 0.350

1001370000 10A Tan gerine, juice 0.003500 0.250 0.350 D20755

Full comment: D207554

1002197000 10B Kumquat 0.004100 1.000 1.000

1002199000 10B Lemon 0.001250 1.000 0.400

1002 200000 10B Lemon, juice 0.001250 0.250 0.400

1002200001 10B Lemon, juice

- babyfood 0.001250 0.250 0.400

1002201000 10B Lemon, peel 0.001250 2.500 0.400 D20755

Full commen t: D207554

1002206000 10B Lime 0.001250 1.000 1.000

1002207000 10B Lime, juice 0.001250 0.250 1.000 D20755

Full comment: D207554

1002207001 10B Lime, juice

- babyfood 0.001250 0.250 1.000

1003180000 10C Grapefruit 0.001250 1.000 0.700

1003181000 10C Grapefruit, juice 0.001250 0.850 0.700 D20755

Full comment: D207554

1003307000 10C Pummelo 0.001250 1.000 1.000

1100007000 11 Apple, fruit with peel 0.003900 1.000 0.100 FT

1100008000 11 Apple, peeled fruit 0.003900 1.000 0.100

1100008001 11 Apple, peeled fruit

- babyfood 0.003900 1.000 0.100

1100009000 11 Apple, dried 0.003900 8.000 0.100

1100009001 11 Apple, dried

- babyfood 0.003900 8.000 0.100

1100010000 11 Apple, juice 0.003900 0.073 0.100

1100010001 11 Apple, juice

- babyfood 0.003900 0.073 0.100

1100011000 11 Apple, sauce 0.003900 1.000 0.100Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 4 4 of 60 1100011001 11 Apple, sauce

- babyfood 0.003900 1.000 0.1 00

1100129000 11 Crabapple 0.003900 1.000 1.000

1100173500 11 Goji berry 0.002700 1.000 1.000 CG8 To

Full comment: CG8 Tomato FT

1100210000 11 Loquat 0.007400 1.000 1.000

1100266000 11 Pear 0.007400 1.000 0.700 FT

1100266001 11 Pear

- babyfood 0.007400 1.000 0.700

1100267000 11 Pear, dried 0.007400 6.250 0.700

1100268000 11 Pear, juice 0.007400 1.000 0.700

1100268001 11 Pear, juice

- babyfood 0.007400 1.000 0.700

1100310000 11 Quince 0.007400 1.000 1.000

1201090000 12A Cherry 0.016000 1.000 0.050

1201090001 12A Cherry

- babyfood 0.016000 1.000 0.050

1201091000 12A Cherry, juice 0.016000 1.500 0.050

1201091001 12A Cherry, juice

- babyfood 0.016000 1.500 0.050

1202012000 12B Apricot 0.005700 1.000 0.150

1202012001 12B Apricot

- babyfood 0.005700 1.000 0.150 peach

Full comment: peach transl

1202013000 12B Apricot, dried 0.005700 6.000 0.150

1202014000 12B Apricot, juice 0.005700 1.000 0.150

1202014001 12B Apricot, juice

- babyfood 0.005700 1.000 0.150

1202230000 12B Nectarine 0.005700 1.000 0.200

1202260000 12B Peach 0.005700 1.000 0.100 FT

1202260001 12B Peach

- babyfood 0.005700 1.000 0.100 FT

1202261000 12B Peach, dried 0.005700 7.000 0.100 FT

1202261001 12B Peach, dried

- babyfood 0.005700 7.000 0.100 FT

1202262000 12B Peach, juice 0.005700 1.000 0.100 FT

1202262001 12B Peach, juice

- babyfood 0.005700 1.0 00 0.100 FT

1203285000 12C Plum 0.002000 1.000 1.000

1203285001 12C Plum

- babyfood 0.002000 1.000 1.000

1203286000 12C Plum, prune, fresh 0.002000 1.000 0.100 FT

120328600 1 12C Plum, prune, fresh

- babyfood 0.002000 1.000 0.100

1203287000 12C Plum, prune, dried 0.002000 5.000 0.100

1203287001 12C Plum, prune, dried

- babyfood 0.002000 5.000 0.100

1203288000 12C Plum, prune, juice 0.002000 1.400 0.100

1203288001 12C Plum, prune, juice

- babyfood 0.002000 1.400 0.100

1301055000 13A Blackberry 0.029300 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1301056000 13A Blackberry, juice 0.029300 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1301056001 13A Blackberry, juice

- babyfood 0.029300 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1301058000 13A Boysenberry 0.045500 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1301208000 13A Loganberry 0.045500 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1301320000 13A Raspberry 0.044500 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1301320001 13A Raspberry

- babyfood 0.044500 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1301321000 13A Rasp berry, juice 0.044500 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1301321001 13A Raspberry, juice

- babyfood 0.044500 1.000 0.560 FT MRI

Full comment: FT MRID 49080101

1302057000 13B Blueberr y 0.017000 1.000 1.000 13

- 07G

1302057001 13B Blueberry

- babyfood 0.017000 1.000 1.000

1302136000 13B Currant 0.000200 1.000 0.050 FHE

1302137000 13B Currant, dried 0.000200 1.000 0.050 FHE

1302149000 13B Elderberry 0.000200 1.000 0.050 FHE

1302174000 13B Gooseberry 0.002300 1.000 1.000 13

- 07F

1302191000 13B Huckleberry 0. 000200 1.000 0.050 FHE

1303227000 13C Mulberry 0.000200 1.000 0.050 FHE

1304175000 13D Grape 0.002300 1.000 0.150 FT

1304176000 13D Grape, juice 0.002300 0.470 0 .150 FT

1304176001 13D Grape, juice

- babyfood 0.002300 0.470 0.150 FTAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 45 of 60 1304179000 13D Grape, wine and sherry 0.002300 1.000 0.150 FT

1304195000 13D Kiwifruit, fuzzy 0.000200 1.000 0.050 FHE

130713000 0 13G Cranberry 0.017000 1.000 1.000 13

- 07G

1307130001 13G Cranberry

- babyfood 0.017000 1.000 1.000

1307131000 13G Cranberry, dried 0.017000 1.000 1.000

1307132000 13G Cranberry, j uice 0.017000 1.100 1.000

1307132001 13G Cranberry, juice

- babyfood 0.017000 1.100 1.000

1307359000 13G Strawberry 0.017000 1.000 0.300

1307359001 13G Strawberry

- babyfood 0. 017000 1.000 0.300

1307360000 13G Strawberry, juice 0.017000 1.000 0.300

1307360001 13G Strawberry, juice

- babyfood 0.017000 1.000 0.300

1400003000 14 Almond 0.001000 1.000 0.700

1400003001 14 Almond

- babyfood 0.001000 1.000 0.700

1400004000 14 Almond, oil 0.001000 1.000 0.700

1400004001 14 Almond, oil

- babyfood 0.001000 1.000 0.700

1400059000 14 Brazil nu t 0.005000 1.000 1.000

1400068000 14 Butternut 0.005000 1.000 1.000

1400081000 14 Cashew 0.005000 1.000 1.000

1400092000 14 Chestnut 0.001000 1.000 1.000

1400155000 14 Hazelnut 0.005000 1.000 0.025

1400156000 14 Hazelnut, oil 0.005000 1.000 0.025

1400185000 14 Hickory nut 0.005000 1.000 1.000

1400213000 14 Macadamia nut 0.005000 1.000 1.000

1400269000 14 Pecan 0.005000 1.000 0.010 FT

1400278000 14 Pine nut 0.001000 1.000 1.000

1400282000 14 Pista chio 0.001000 1.000 0.025

1400391000 14 Walnut 0.001000 1.000 0.250 FT

1500025000 15 Barley, pearled barley 0.000200 1.000 0.050 FHE

1500025001 15 Barley, pearled barley

- ba byfood 0.000200 1.000 0.050 FHE

1500026000 15 Barley, flour 0.000200 1.000 0.050 FHE

1500026001 15 Barley, flour

- babyfood 0.000200 1.000 0.050 FHE

1500027000 15 Barley, bran 0.0002 00 1.000 0.050 FHE

1500065000 15 Buckwheat 0.000200 1.000 0.050 FHE

1500066000 15 Buckwheat, flour 0.000200 1.000 0.050 FHE

1500120000 15 Corn, field, flour 0.000200 1.000 0.05 0 FHE

1500120001 15 Corn, field, flour

- babyfood 0.000200 1.000 0.050 FHE

1500121000 15 Corn, field, meal 0.000200 1.000 0.050 FHE

1500121001 15 Corn, field, meal

- babyfood 0.000200 1.000 0.050 FHE

150012200 0 15 Corn, field, bran 0.000200 1.000 0.050 FHE

1500123000 15 Corn, field, starch 0.000200 1.000 0.050 FHE

1500123001 15 Corn, field, starch

- babyfood 0.000200 1.000 0.050 FHE

1500124000 15 Corn, field, syrup 0.000200 1.000 0.050 FHE

1500124001 15 Corn, field, syrup

- babyfood 0.000200 1.000 0.050 FHE

1500125000 15 Corn, field, oil 0.000200 1.000 0.050 FHE

1500125001 15 Corn, field, oil

- babyf ood 0.000200 1.000 0.050 FHE

1500126000 15 Corn, pop 0.000200 1.000 0.050 FHE

1500127000 15 Corn, sweet 0.006000 1.000 0.450 FT MRI

Full comment: FT MRID 49071008

15001270 01 15 Corn, sweet

- babyfood 0.006000 1.000 0.450 FT MRI

Full comment: FT MRID 49071008

1500226000 15 Millet, grain 0.000200 1.000 0.050 FHE

1500231000 15 Oat, bran 0.00020 0 1.000 0.050 FHE

1500232000 15 Oat, flour 0.000200 1.000 0.050 FHE

1500232001 15 Oat, flour

- babyfood 0.000200 1.000 0.050 FHE

1500233000 15 Oat, groats/rolled oats 0.000200 1.000 0.050 FHE

1500233001 15 Oat, groats/rolled oats

- babyfood 0.000200 1.000 0.050 FHE

1500323000 15 Rice, white 0.000200 1.000 0.050 FHE

1500323001 15 Rice, white

- babyfood 0.000200 1.000 0.050 FHE

1500324000 15 Rice, brown 0.000200 1.000 0.050 FHE

1500324001 15 Rice, brown

- babyfood 0.000200 1.000 0.050 FHE

1500325000 15 Rice, flour 0.000200 1.000 0.050 FHE

1500325001 15 Rice, flou r

- babyfood 0.000200 1.000 0.050 FHE

1500326000 15 Rice, bran 0.000200 1.000 0.050 FHE

1500326001 15 Rice, bran

- babyfood 0.000200 1.000 0.050 FHE

1500328000 15 Rye, grain 0.000200 1.000 0.050 FHEAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 46 of 60 1500329000 15 Rye, flour 0.000200 1.000 0.050 FHE

1500344000 15 Sorghum, grain 0.000200 1.000 0.050 FHE

1500345000 15 Sorghum, syrup 0.00020 0 1.000 0.050 FHE

1500381000 15 Triticale, flour 0.000200 1.000 0.050 FHE

1500381001 15 Triticale, flour

- babyfood 0.000200 1.000 0.050 FHE

1500401000 15 Wheat, grain 0.000200 1.000 0.050 FHE

1500401001 15 Wheat, grain

- babyfood 0.000200 1.000 0.050 FHE

1500402000 15 Wheat, flour 0.000200 1.000 0.050 FHE

1500402001 15 Wheat, flour

- babyfood 0.000200 1.000 0.050 FHE

1500403000 15 Wheat, germ 0.000200 1.000 0.050 FHE

1500404000 15 Wheat, bran 0.000200 1.000 0.050 FHE

1500405000 15 Wild rice 0.000200 1.000 0.050 FHE

1800002000 18 Alfalfa, s eed 0.000200 1.000 0.050 FHE

1901028000 19A Basil, fresh leaves 0.008000 1.000 1.000 herb s

Full comment: herb subgroup except chives

1901028001 19A Basil, fresh leaves

- babyfood 0.008000 1.0 00 1.000

1901029000 19A Basil, dried leaves 0.019000 1.000 1.000

1901029001 19A Basil, dried leaves

- babyfood 0.019000 1.000 1.000

1901102500 19A Chive, dried leaves 0.004100 2.900 1.000 D38079

Full comment: D380795, MRID 48135002

1901118000 19A Cilantro, leaves 0.008000 1.000 1.000 herb s

Full comment: herb subgroup except chives

1901118001 19A Cilantro, leaves

- babyfood 0.008000 1.000 1.000

1901144000 19A Dillweed 0.008000 1.000 1.000 herb s

Full comment: herb subgroup except chives

1901184000 19A Herbs, other 0.008000 1.000 1.000 herb s

Full comment: herb subgr oup except chives

1901184001 19A Herbs, other

- babyfood 0.008000 1.000 1.000

1901202000 19A Lemongrass 0.008000 1.000 1.000 herb s

Full comment: herb subgroup except chives

1901220000 19A Marjoram 0.008000 1.000 1.000 herb s

Full comment: herb subgroup except chives

1901220001 19A Marjoram

- babyfood 0.008000 1.000 1.000

1901249000 19A Parsley, dried leaves 0.019000 1.000 1.000 herb s

Full comment: herb subgroup except chives

1901249001 19A Parsley, dried leaves

- babyfood 0.019000 1.000 1.000

1901334000 19A Savory 0.008000 1.000 1.000 herb s

Full comm ent: herb subgroup except chives

1902105000 19B Cinnamon 0.000200 1.000 0.050 FHE

1902105001 19B Cinnamon

- babyfood 0.000200 1.000 0.050 FHE

1902119000 19B Coriander, seed 0.000200 1 .000 0.050 FHE

1902119001 19B Coriander, seed

- babyfood 0.000200 1.000 0.050 FHE

1902143000 19B Dill, seed 0.000200 1.000 0.050 FHE

1902274000 19B Pepper, black and white 0.000200 1.000 0.050 FHE

1902274001 19B Pepper, black and white

- babyfood 0.000200 1.000 0.050 FHE

1902354000 19B Spices, other 0.000200 1.000 0.050 FHE

1902354001 19B Spices, other

- babyfood 0.000200 1.000 0.050 FHE

2001163000 20A Flax seed, oil 0.000200 1.000 0.050 FHE

2001319000 20A Rapeseed, oil 0.000200 1.000 0.050 FHE

2001319001 20A Rapeseed, oil

- babyfood 0.000200 1.000 0.050 FHE

2001336000 20A Sesame, seed 0.000200 1.000 0.050 FHE

2001336001 20A Sesame, seed

- babyfood 0.000200 1.000 0.050 FHE

2001337000 20A Sesame, oil 0.000200 1.000 0.050 FHE

2001337001 20A Sesame, oil

- babyfood 0.000200 1.000 0.050 FHE

2002330000 20B Safflower, oil 0.000200 1.000 0.050 FHE

2002330001 20B Safflower, oil

- babyfood 0.000200 1.000 0.050 FHE

2002364000 20B Sunflower, seed 0.000200 1 .000 0.050 FHE

2002365000 20B Sunflower, oil 0.000200 1.000 0.050 FHE

2002365001 20B Sunflower, oil

- babyfood 0.000200 1.000 0.050 FHE

2003114001 20C Coconut, oil

- babyfood 0.000200 1.000 0.050 FHE

2003128000 20C Cottonseed, oil 0.007000 1.000 0.200

2003128001 20C Cottonseed, oil

- babyfood 0.007000 1.000 0.200

2100228000 21 Mushroom 0.000200 1.000 0.050 FHE

3100044000 31 Beef, meat 0.008400 1.000 0.450

3100044001 31 Beef, meat

- babyfood 0.008400 1.000 0.450Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 47 of 60 3100045000 31 Beef, meat, dried 0.008400 1.920 0.450

3100046000 31 Beef, mea t byproducts 0.076000 1.000 0.450

3100046001 31 Beef, meat byproducts

- babyfood 0.076000 1.000 0.450

3100047000 31 Beef, fat 0.038000 1.000 0.450

3100047001 31 Beef, fat

- babyfood 0.038000 1.000 0.450

3100048000 31 Beef, kidney 0.026000 1.000 0.450

3100049000 31 Beef, liver 0.076000 1.000 0.450

3100049001 31 Beef, liver

- babyfood 0.076000 1.000 0.450

3200169000 32 Goat, meat 0.002700 1.000 0.450

3200170000 32 Goat, meat byproducts 0.011000 1.000 0.450

3200171000 32 Goat, fat 0.008800 1.000 0.450

3200172000 32 Goat, k idney 0.002700 1.000 0.450

3200173000 32 Goat, liver 0.011000 1.000 0.450

3300189000 33 Horse, meat 0.002400 1.000 0.450

3400290000 34 Pork, meat 0.020000 1.000 0.050 FHE

3400290001 34 Pork, meat

- babyfood 0.020000 1.000 0.050 FHE

3400291000 34 Pork, skin 0.020000 1.000 0.050 FHE

3400292000 34 Pork, meat byproducts 0.020000 1. 000 0.050 FHE

3400292001 34 Pork, meat byproducts

- babyfood 0.020000 1.000 0.050 FHE

3400293000 34 Pork, fat 0.010000 1.000 0.050 FHE

3400293001 34 Pork, fat

- babyfood 0.010000 1.000 0.050 FHE

3400294000 34 Pork, kidney 0.020000 1.000 0.050 FHE

3400295000 34 Pork, liver 0.020000 1.000 0.050 FHE

3500339000 35 Sheep, meat 0.002400 1.000 0.450

3500339001 35 She ep, meat

- babyfood 0.002400 1.000 0.450

3500340000 35 Sheep, meat byproducts 0.024000 1.000 0.450

3500341000 35 Sheep, fat 0.016800 1.000 0.450

3500341001 35 Sheep, fat

- babyfood 0.016800 1.000 0.450

3500342000 35 Sheep, kidney 0.006000 1.000 0.450

3500343000 35 Sheep, liver 0.024000 1.000 0.450

3600222000 36 Milk, fat 0.011000 1.000 0.450

3600222001 36 Milk, fat

- baby food/infant formu 0.011000 1.000 0.450

3600223000 36 Milk, nonfat solids 0.011000 1.000 0.450

3600223001 36 Milk, nonfat solids

- baby food/in 0.011000 1.000 0.450

3600224000 36 Milk, water 0.011000 1.000 0.450

3600224001 36 Milk, water

- babyfood/infant form 0.011000 1.000 0.450

3600225001 36 Milk, sugar (lactose)

- baby food/ 0.011000 1.000 0.450

3800221000 38 Meat, game 0.000200 1.000 0.050 FHE

3900312000 39 Rabbit, meat 0.000200 1.000 0.050 FHE

4000093000 40 Chicken, meat 0.020000 1.000 0.050 FHE

4000093001 40 Chicken, meat

- babyfood 0.020000 1.000 0.050 FHE

4000094000 40 Chicken, liver 0.020000 1.000 0.050 FHE

4000095000 40 Chicken, meat byproducts 0.020000 1.000 0.050 FHE

4000095001 40 Chicken, meat byproducts

- babyfoo 0.020000 1.000 0.050 FHE

4000096000 40 Chicken, fat 0.010000 1.000 0.050 FHE

4000096001 40 Chicken, fat

- babyfood 0.010000 1.000 0.050 FHE

4000097000 40 Chicken, skin 0.020000 1.000 0.050 FHE

4000097001 40 Chicken, skin

- babyfood 0.020000 1.000 0.050 FHE

5000382000 50 Turkey, meat 0.020000 1.000 0.050 FHE

5000382001 50 Turkey, meat

- babyfood 0.020000 1.000 0.050 FHE

5000383000 50 Turkey, liver 0.020000 1.000 0.050 FHE

5000383001 50 Turkey, liver

- babyfood 0.020000 1.000 0.050 FHE

5000384000 50 Turkey, meat byproducts 0.020000 1.000 0.050 FH E

5000384001 50 Turkey, meat byproducts

- babyfood 0.020000 1.000 0.050 FHE

5000385000 50 Turkey, fat 0.010000 1.000 0.050 FHE

5000385001 50 Turkey, fat

- babyfood 0.020000 1.000 0.050 FHE

5000386000 50 Turkey, skin 0.020000 1.000 0.050 FHE

5000386001 50 Turkey, skin

- babyfood 0.020000 1.000 0.050 FHE

6000301000 60 Poultry, other, meat 0.001000 1.000 0.200 FHE

6000302000 60 Poultry, other , liver 0.000500 1.000 0.200 FHE

6000303000 60 Poultry, other, meat byproducts 0.005000 1.000 0.200 FHE

6000304000 60 Poultry, other, fat 0.005000 1.000 0.050 FHE

6000305000 60 Poultry, other, skin 0.005000 1.000 0.200 FHE

7000145000 70 Egg, whole 0.020000 1.000 0.050 FHE

7000145001 70 Egg, whole

- babyfood 0.020000 1.000 0.050 FHEAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 48 of 60 7000146000 70 Egg, white 0.020000 1.000 0.050 FHE

7000146001 70 Egg, white (solids)

- babyfood 0.020000 1.000 0.050 FHE

7000147000 70 Egg, yolk 0.020000 1.000 0.050 FHE

7000147001 70 Egg, yolk

- babyfood 0.020000 1.000 0.050 FH E

8000157000 80 Fish

- freshwater finfish 0.000200 1.000 0.050 FHE

8000158000 80 Fish

- freshwater finfish, farm ra 0.000200 1.000 0.050 FHE

8000159000 80 Fish

- saltwater finfish, tuna 0.000200 1.000 0.050 FHE

8000160000 80 Fish

- saltwater finfish, other 0.000200 1.000 0.050 FHE

8000161000 80 Fish

- shellfish, crustacean 0.000200 1.000 0.050 FHE

8000162000 80 Fish

- shellfish, mollusc 0.000200 1.000 0.050 FHE

8601000000 86A Water, direct, all sources 0.000300 1.000 1.000

8601100000 86A Water, direct, tap 0.000000 1.000 1.000

8601200000 86A Water, direct, bottled 0.000000 1.000 1.000

8601300000 86A Water, direct, other 0.00 0000 1.000 1.000

8601400000 86A Water, direct, source

- NS 0.000000 1.000 1.000

8602000000 86B Water, indirect, all sources 0.000300 1.000 1.000

8602100000 86B Water, indirect, tap 0.000000 1.000 1.000

860 2200000 86B Water, indirect, bottled 0.000000 1.000 1.000

8602300000 86B Water, indirect, other 0.000000 1.000 1.000

8602400000 86B Water, indirect, source

- NS 0.000000 1.000 1.000

9500000500 O Acai berry 0.000200 1.000 1.000 FHE

9500001000 O Acerola 0.004300 1.000 1.000 D42400

Full comment: D424008

9500001500 O Agave 0.000200 1.000 0.050 FHE

9500006 000 O Amaranth, grain 0.000200 1.000 0.050 FHE

9500016000 O Artichoke, globe 0.000200 1.000 0.050 FHE

9500019000 O Asparagus 0.000200 1.000 0.050 FHE

9500019500 O Atemoya 0.000200 1.000 0.050 FHE

9500020000 O Avocado 0.004700 1.000 0.350

9500022000 O Bamboo, shoots 0.000200 1.000 0.050 FHE

9500023000 O Banana 0.000200 1.000 0.050 FHE

9500023001 O Banana

- babyfood 0.000200 1.000 0.050 FHE

9500024000 O Banana, dried 0.000200 1.000 0.050 FHE

9500024001 O Banana, dried

- babyfood 0.00020 0 1.000 0.050 FHE

9500054000 O Belgium endive 0.000200 1.000 0.050 FHE

9500060000 O Breadfruit 0.000200 1.000 0.050 FHE

9500073000 O Cactus 0.000200 1.000 0.050 FHE

9500074000 O Canistel 0.000200 1.000 0.050 FHE

9500077000 O Carob 0.000200 1.000 0.050 FHE

9500089000 O Cherimoya 0.000200 1.000 0.050 FHE

9500109000 O Cocoa bean, chocolate 0.000200 1.000 0.050 FHE

9500110000 O Cocoa bean, powder 0.000200 1.000 0.050 FHE

9500111000 O Coconut, meat 0.000200 1.000 0.050 FHE

9500111001 O Coconut, m eat

- babyfood 0.000200 1.000 0.050 FHE

9500112000 O Coconut, dried 0.000200 1.000 0.050 FHE

9500113000 O Coconut, milk 0.000200 1.000 0.050 FHE

9500114000 O Coconut, oil 0.000200 1.000 0.050 FHE

9500115000 O Coffee, roasted bean 0.000200 1.000 0.050 FHE

9500116000 O Coffee, instant 0.000200 1.000 0.050 FHE

9500141000 O Date 0.000200 1.000 0.050 FHE

9500151000 O Feijoa 0.004300 1.000 1.000 D42400

Full comment: D424008

9500153000 O Fig 0.000200 1.000 0.050 FHE

9500154000 O Fig, dried 0.000200 1.000 0.050 FHE

9500177000 O Grape, leaves 0.002300 1.000 0.150 FT

9500178000 O Grape, raisin 0.002300 0.750 0.150 FT

9500183000 O Guava 0.004300 1.000 1.000 D42400

Full comment: D424008, MRID 49455903

9500183001 O Guava

- babyfood 0.004300 1.000 1.000 D42400

Full comment: D424008, MRID 49455903

9500186000 O Honey 0.000200 1.000 0.050 FHE

9500186001 O Honey

- babyfood 0.000200 1.000 0.050 FHE

9500188000 O Hop 0.051000 1.000 1.000

9500193000 O Jackfruit 0.000200 1.000 0.050 FHE

9500209000 O Longan 0.002400 1.000 1.000 D42400Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 49 of 60 Full comment: D424008

9500211000 O Lychee 0.002400 1.000 1.000 D42400

Full comment: D424008, MRID 49455905

9500212000 O Lychee, dried 0.002400 1.850 1.000 D42400

Full comment: D424008, MRID 49455905

9500214000 O Mamey apple 0.000200 1.000 0.050 FHE

9500215000 O Mango 0.000200 1.000 0.050 FHE

9500215001 O Mango

- babyfood 0.000200 1.000 0.050 FHE

9500216000 O Mango, dried 0.000200 1.000 0.050 FHE

9500217000 O Mango, juice 0.000200 1.000 0.050 FHE

9500217001 O Mango, juice

- babyfood 0.000200 1.000 0.050 FHE

9500218000 O Maple, sugar 0.000200 1.000 0.050 FHE

9500219000 O Maple syrup 0.000200 1.000 0.050 FHE

9500235000 O Olive 0.000200 1.000 0.050 FHE

9500236000 O Olive, oil 0.000200 1.000 0.050 FHE

9500243000 O Palm heart, leaves 0.000200 1.000 0.050 FH E

9500244000 O Palm, oil 0.000200 1.000 0.050 FHE

9500244001 O Palm, oil

- babyfood 0.000200 1.000 0.050 FHE

9500245000 O Papaya 0.086300 1.000 1.000 D42400

Full comment: D424008, MRID 49455906

9500245001 O Papaya

- babyfood 0.086300 1.000 1.000

9500246000 O Papaya, dried 0.086300 1.800 1.000 Blende

Full comment: Blended

9500247000 O Papaya, juice 0.086300 1.500 1.000

9500252000 O Passionfruit 0.004300 1.000 1.000 D42400

Full comment: D424008

9500252001 O Passionfruit

- babyfood 0.004300 1.000 1.000

950025300 0 O Passionfruit, juice 0.004300 1.000 1.000

9500253001 O Passionfruit, juice

- babyfood 0.004300 1.000 1.000

9500254000 O Pawpaw 0.000200 1.000 0.050 FHE

9500263000 O Peanut 0.000200 1.000 0.050 FHE

9500264000 O Peanut, butter 0.000200 1.000 0.050 FHE

9500265000 O Peanut, oil 0.000200 1.000 0.050 FHE

9500275000 O Peppermint 0.047000 1.000 1.000

9500276000 O Peppermint, oil 0.047000 1.000 1.000

9500277000 O Persimmon 0.000200 1.000 0.050 FHE

9500279000 O Pineapple 0.004000 1.000 1.000 D42400

Full comment: D424008

9500279001 O Pineapple

- babyfood 0.004000 1.000 1.000

9500280000 O Pineapple, dried 0.004000 5.000 1.000

9500281000 O Pineapple, juice 0.004000 1.700 1.000

9500281001 O Pineapple, juice

- babyfood 0.004000 1.700 1.000

9500283000 O Plantain 0.000200 1.000 0.050 FHE

9500284000 O Planta in, dried 0.000200 1.000 0.050 FHE

9500289000 O Pomegranate 0.000200 1.000 0.050 FHE

9500306000 O Psyllium, seed 0.000200 1.000 0.050 FHE

9500311000 O Quinoa, grain 0.000200 1.000 0.050 FHE

9500333000 O Sapote, Mamey 0.086300 1.000 1.000 D42400

Full comment: D424008

9500335000 O Seaweed 0.000200 1.000 0.050 FHE

9500335001 O S eaweed

- babyfood 0.000200 1.000 0.050 FHE

9500346000 O Soursop 0.000200 1.000 0.050 FHE

9500351000 O Spanish lime 0.002400 1.000 1.000 D42400

Full comment: D424 008

9500352000 O Spearmint 0.047000 1.000 1.000

9500353000 O Spearmint, oil 0.047000 1.000 1.000

9500358000 O Starfruit 0.004300 1.000 1.000 D42400

Ful l comment: D424008

9500361000 O Sugar apple 0.000200 1.000 0.050 FHE

9500362000 O Sugarcane, sugar 0.000200 1.000 0.050 FHE

9500362001 O Sugarcane, sugar

- babyfood 0.000200 1.000 0.050 F HE

9500363000 O Sugarcane, molasses 0.000200 1.000 0.050 FHE

9500363001 O Sugarcane, molasses

- babyfood 0.000200 1.000 0.050 FHE

9500368000 O Tamarind 0.000200 1.000 0.050 FHE

9500372000 O Tea, dried 0.000200 1.000 0.050 FHEAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 50 of 60 9500373000 O Tea, instant 0.000200 1.000 0.050 FHE

9500373500 O Teff, flour 0.000200 1.000 0.050 FHE

9500390000 O Vinegar 0.000200 1.000 0.050 FHE

9500397000 O Water chestnut 0.000200 1.000 0.050 FHE

9500398000 O Watercress 0.000200 1.000 0.050 FHEAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 51 of 60 

### Attachment 7 : Chronic Food plus Water Result s File

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for AVERMECTIN NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ KRURY \ Documents \ My Work Files \ Abamectin \ Dietary F iles \ Abamectin

chronic PRIA 3 29 16.R08

Adjustment factor #2 used.

Analysis Date 03

- 29

- 2016/13:13:10 Residue file dated: 03

- 29

- 2016/09:11:57

Reference dose (RfD, Chronic) = .0025 mg/kg bw/day

======= ========================================================================

Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of

Subgroup body wt/day Rfd

-- ------------------------------------ ------------- ---------------- Total US Population 0.000056 2.2%

Hispanic 0.000067 2.7%

Non

- Hisp

- White 0.000055 2.2%

Non

- Hisp

- Black 0.000047 1.9%

Non

- Hisp

- Other 0.000060 2.4%

Nursing Infants 0.000039 1.6%

Non

- Nursing Infants 0.000122 4.9%

Female 13+ PREG 0.000047 1.9%

Children 1

- 6 0.000193 7.7%

Children 7

- 12 0.000083 3.3%

Male 13

- 19 0.000049 2.0%

Female 13

- 19/NP 0.000041 1.6%

Male 20+ 0.000038 1.5%

Female 20+/NP 0.000037 1.5%

Seniors 55+ 0.000037 1.5%

All Infants 0.000096 3.9%

Female 13

- 50 0.000038 1.5%

**Children 1**

**- 2 0.000268 10.7%** 

Children 3

- 5 0.000160 6.4%

Children 6

- 12 0.000090 3.6%

Youth 13

- 19 0.000045 1.8%

Adults 20

- 49 0.000038 1.5%

Adults 50

- 99 0.000037 1.5%

Female 13

- 49 0.000038 1.5%

-------------------------------------------------------------------------------Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 52 of 60 

### Attachment 8 : Acute Water Only Residue Input File

Filename: C: \ Users \ ndodd \ Documents \ DEEM Version 3.16 \ Abamectin Soybean 2014 \ AVERMECTIN ACUTE Water

Only 102714.R08

Chemical: Avermectin

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 10

- 27

- 2014/15:33:59 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

----- ---- ---------- -- -------- -------- -------

1 6 Aba_MSsoyb_MSsoybeanSTD_Reservoir_Parent_DEEM.rdf

EPA Crop Commodity Name Def Res Adj.Factors RDLComment

Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 8601000000 86A Water, direct, all sources 0.000760 1.000 1.000 1

8602000000 86B Water, indirect, all sources 0.000760 1.000 1.000 1



### Attachment 9 : Acute Water Only Results File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for AVERMECTIN NHANES 2003

- 2008 2

- Day

Residue file: AVERMECTIN ACUTE Water Only 102 714.R08

Adjustment factor #2 used.

Analysis Date: 10

- 27

- 2014/15:43:24 Residue file dated: 10

- 27

- 2014/15:33:59

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

**Summary calculations**

**-- per capita:** 

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.000009 0.35 0.000015 0.62 0.000031 1.24

All Infants: 0.000027 1.07 0.000044 1.74 0.000077 3.08

Children 1

- 2: 0.000013 0.52 0.000023 0.93 0.000049 1.94

Children 3

- 5: 0.000011 0.43 0.000018 0.73 0.000035 1.41

Children 6

- 12: 0.000008 0.32 0.000014 0.57 0. 000027 1.06

Youth 13

- 19: 0.000007 0.28 0.000013 0.50 0.000023 0.93

Adults 20

- 49: 0.000008 0.34 0.000014 0.57 0.000025 1.02

Adults 50

- 99: 0.000008 0.31 0.000013 0.52 0.000023 0.93

Female 13

- 49 : 0.000009 0.34 0.000014 0.57 0.000026 1.02Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 53 of 60 

### Attachment 10 : Chronic Water Only Residue Input File

Filename: C: \ Users \ ndodd \ Documents \ DEEM Version 3.16 \ Abamectin Soybean 2014 \ AVERMECTIN CHRONIC

Water Only 102714.R08

Chemical: Avermecti n

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 09

- 17

- 2014/15:17:15 Program ver. 3.16, 03

- 08

- d

------------------------------------------------ ----------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 8601000000 86A Water, direct, all sources 0.000300 1.000 1.000

8602000000 86B Water, indirect, all sources 0.000300 1.000 1.000



### A ttachment 11 : Chronic Water Only Results File

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for AVERMECTIN NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ ndodd \ Documents \ DEEM Version 3.16 \ Abamectin Soybean 2014 \ AVERMECTIN

CHRONIC Water Only 10271 4.R08

Adjustment factor #2 used.

Analysis Date 10

- 27

- 2014/14:21:54 Residue file dated: 09

- 17

- 2014/15:17:15

Reference dose (RfD, Chronic) = .0025 mg/kg bw/day

========================================= ======================================

Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of

Subgroup body wt/day Rfd

------------------------------------ -- ------------- ---------------- Total US Population 0.000006 0.3%

Hispanic 0.000006 0.2%

Non

- Hisp

- White 0.000006 0.3%

Non

- Hisp

- Black 0.000005 0.2%

Non

- Hisp

- Other 0.000007 0.3%

Nursing Infants 0.000006 0.2%

Non

- Nursing Infants 0.000021 0.8%

Female 13+ PREG 0.000006 0.2%

Children 1

- 6 0.000008 0.3%

Children 7

- 12 0.000005 0.2%

Male 13

- 19 0.000004 0.2%

Female 13

- 19/NP 0.000005 0.2%

Male 20+ 0.000006 0.2%

Female 20+/NP 0.000007 0.3%

Seniors 55+ 0.000006 0.2%

All Infants 0.000016 0.6%

Female 13

- 50 0.000006 0.3%

Children 1

- 2 0.000009 0.4%

Children 3

- 5 0.000008 0.3%

Children 6

- 12 0.000006 0.2%

Youth 13

- 19 0.000005 0.2%

Adults 20

- 49 0.000006 0.3%

Adults 50

- 99 0.000006 0.2%

Female 13

- 49 0.00 0006 0.2%

-------------------------------------------------------------------------------Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 54 of 60 

### Attachment 12 : BEAD Percent Crop Treated Data

Table 11. Screening Level Estimates of Agricultural Uses of Abamectin

Crop Percent Crop Treated

July 1, 2015 1 August 27, 2015 2

Average Maximum Average Maximum

Almonds 70 80

-- Apples 10 30

-- -- Apricots 15 30

-- --

Avocados 35 60

-- -- Beans, dry <2.5 <2.5

Caneberries

-- -- 56 68

Cantaloupes 25 45

-- -- Celery 45 70

-- --

Cherries 5 20

-- --

Cotton 20 30

-- --

Cucumbers 5 10

-- -- Grapefruit 70 90

-- -- Grapes 15 35

-- --

Hazelnuts <2.5 <2.5

-- -- Honeydew 20 35

-- --

Lemons 40 55

-- --

Lettuce 20 45

-- --

Nectarines 20 20

-- --

Onions <2.5 10

Oranges 40 70

-- --

Peaches 10 25

-- --

Pears 70 85

-- --

Pecans <1 <2.5

-- -- Peppers 15 30

-- --

Pistachios <2.5 <2.5

-- --

Plums/Prunes 10 35

Potatoes 5 20

-- -- Pumpkins 5 10

-- -- Soybean

-- -- 8 11

Spinach 25 45

-- -- Squash 5 15

-- --

Strawberries 30 45

-- --

Sweet corn

-- -- 45 57

Tangerines 35 55

-- --

Tomatoes 10 25

-- --

Walnuts 25 55

-- --

Watermelons 5 15

-- --

1 Memo with no DP number, Jihad Alsadek, 7/1/15

. SLUA data sources include: USDA

- NASS

and Private Pesticide Market Research

.

2 D42 8074 , Don Atwood, Ph.D., 8/27/15

. The data source was proprietary data from 2011

- 2013

.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 55 of 60 

### Attachment 13. Calculation of Livestock Anticipated Residues

13.1 . Livestock Dietary Burden Estimations

A summary of all of the livestock feeds considered in a more balanced diet (MDB) is presented in

Table 13.1.1.

Table 13.1.1. Feeds Considered in More Balanced Diet

– Acute Assessment

Crop Commodity Type Input %DM Max

%Diet % Diet

Used

Beef Cattle

Cotton Hulls R 0.006 Median 90 10 10

Citrus Pulp, dried R 0.02 Median 91 10 0

Cotton Gin byproducts R 0.018 Median 90 5 0

Pineapple Process residue R 0.016 Median 25 10 0

Grain Aspirated grain fractions CC 0.4 Median 85 5 5

Potato Culls CC 0.0027 HR 20 30 0

Potato Process Waste CC 0.0027 Median 12 30 0

Cotton Meal PC 0.006 Median 89 5 5

Soybean Seed PC 0.006 Median 89 5 0

Dairy Cattle

Corn,

sweet Forage R 0.102 HR 48 45 45

Almond Hulls R 0.039 Median 90 10 0

Citrus Pulp, dried R 0.02 Median 91 10 0

Pineapple Process residue R 0.016 Median 25 10 0

Corn,

sweet Cannery waste CC 0.063 Median 30 10 10

Apples Pomace, wet CC 0.02 Median 40 10 0

Potato Culls CC 0.0027 HR 20 10 0

Potato Process Waste CC 0.0027 Median 12 10 0

Cotton Undelinted seed PC 0.006 Median 88 10 10

Cotton Meal PC 0.006 Median 89 10 0

Soybean Seed PC 0.006 Median 89 10 0

Poultry

Cotton Meal PC 0.006 Median 89 20 20

Soybean Seed PC 0.006 Median 89 20 5

Swine

Cotton Meal PC 0.006 Median 89 15 15

Soybean Seed PC 0.006 Median 89 15 0



### A summary of the livestock feed items that results in the highest dietary burden using the guidance

for a more balanced diet is presented in table 13.1.2.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 56 of 60

Table 13. 1 .2 . More Balanced Diet (MBD) Used for Dietary Burden Estimation for Tolerance Estimates and

Anticipated Residues

Crop Commodity Type Residue %DM %Diet Dietary Contribution

,

ppm ppm input

Beef Cattle

Cotton Hulls R 0.006 Median 90 10 0.0007

Grain Aspirated grain fractions CC 0.4 Tolerance 85 5 0.02

Cotton Meal PC 0.006 Median 89 5 0.0003

Untreated feed NA NA NA NA NA 80 0

Total NA NA NA NA NA 100 0.02

Dairy Cattle

Corn, sweet Forage R 0.102 HR 48 45 0.10

Corn, sweet Cannery waste CC 0.063 Median 30 10 0.02

Cotton Undelinted seed PC 0.006 Median 88 10 0.0007

Untreated feed NA NA NA NA NA 35 0

Total NA NA NA NA NA 100 0.12

Poultry

Cotton Meal PC 0.006 Median 89 20 0.001

Soybean Seed PC 0.006 Median 89 5 0.0003

Untreated feed NA NA NA NA NA 75 0

Total NA NA NA NA NA 100 0.002

Swine

Cotton Meal PC 0.006 Median 89 15 0.0009

Untreated feed NA NA NA NA NA 85 0

Total NA NA NA NA NA 100 0.0009



### 13.2 Livestock Feeding Studies

– Determination of Tissue to Feed Ratios

RCB #1568, L. Cheng, 2/11/87

Feeding studies have been submitted only for cattle at feeding levels of 0.01, 0.03, and 0.1 ppm.

The results of the residue analyses and tissue to feed ratios are presented in Table 13.4.1. The

tissue to feed ratios from the dose level closest to the di etary burden was used in the calculation.

Therefore, the 0.1 ratio was used for estimated residues in tissues and milk

Table 13.2 . Summary of Livestock Feeding Studies with Abamectin.

Commodity Feeding Level, ppm Residue in Tissue /Milk , ppm 1 Tissue

- to

- Feed Ratio

Milk 0.010 ND 2

--

0.030 0.001 0.033

0.100 0.004 0.040

Muscle

(cattle) 0.010 0.002 0.20

0.030 0.002 0.067

0.100 0.002 0.02

Fat (cattle) 2 0.010 0.002 0.20

0.030 0.006 0.20

0.100 0.014 0.14

Liver (cattle) 0.010 0.004 0.40

0.030 0.008 0.27Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 57 of 60 Table 13.2 . Summary of Livestock Feeding Studies with Abamectin.

Commodity Feeding Level, ppm Residue in Tissue /Milk , ppm 1 Tissue

- to

- Feed Ratio

0.100 0.020 0.2

Kidney

(cattle) 0.010 0.002 0.2

0.030 0.002 0.067

0.100 0.005 0.05

1 maximum residue

2 ND = not detectable.



### 13. 3 . Estimation of Residues in Livestock Commodities

– Cattle, Goat, Sheep, Horses

Residues of abamectin can be expected in cattle commodities from consumption of treated feed as

well as dermal exposure from ear tags. There are no ear tag uses registered for the remaining types

of livestock. U pper bound residues are assumed from a diet based on the maximum reasonable

dietary burden used to calculate the tolerances. The secondary residues from cattle consuming

treated feed were added to the upper bound residues from the ear tag for the total abamectin

residues in each edible livestock commodity . Th is is considered to be a conservative estimate

since upper bound residues from crop field trials were used assuming maximum dietary burden;

actual residues in treated feed are likely to be lower.

The dietary burden estimates were highest for dairy cattle, so the secondary residues will be based

on the burden of 0.12 ppm. A summary of the estimated residues is presented in Table 13.3. For

acute assessments, the percent crop treated is based on the maximum percent crop treated of any of

the feed items inclu ded in the diet, sweet corn at 57%. For the chronic assessments, the percent

crop treated is also based on sweet corn at 45%.

Table 13.3 Estimated Residues in Livestock Commodities

Commodity Tissue to

Feed Ratio Dietary

Burden

(ppm) Estimated

Residue from

Livestock Feed

(ppm) Estimated

Residue from

Cattle Ear Tag

Use 1

(ppm) Total

Estimated

Residue

(ppm)

Cattle, fat 0.14 0.12 0.0168 0.018 0.0384 0.0036

Cattle, meat 0.02 0.12 0.0024 0.005 0.0084 0.001

Cattle, meat byproducts

(Liver) 0.2 0.12 0.024 0.043 0.0756 0.0086

Cattle, meat byproducts;

(Kidney) 0.05 0.12 0.006 0.017 0.0264 0.0034

Milk 0.04 0.12 0.0048 0.0046 0.011

Goat, fat 0.12 0.0088

-- 0.0088

Goat, meat 0.12 0.0027

-- 0.0027

Goat, meat byproducts;(Liver) 0.12 0. 011

-- 0.011

Goat, meat byproducts

(Kidney) 0.0027

-- 0.0027

Sheep, horse, meat 0.12 0.0024

-- 0.0024Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 58 of 60 Table 13.3 Estimated Residues in Livestock Commodities

Commodity Tissue to

Feed Ratio Dietary

Burden

(ppm) Estimated

Residue from

Livestock Feed

(ppm) Estimated

Residue from

Cattle Ear Tag

Use 1

(ppm) Total

Estimated

Residue

(ppm)

Sheep, meat byproducts, incl.

liver 0.12 0.024

-- 0.024

Sheep, fat 0.12 0.0168

-- 0.0168

Sheep, kidney 0.12 0.0060

-- 0.0060



### 13.4 . Estimation of Residues in Livestock Commodities

- Poultry and Swine

Tolerances are established on Poult ry, Hog Meat, Meat by

- products at 0.02 ppm and Hog Fat at

0.01 ppm based on the food handling establishment (FHE) use. As noted in table 13.1.2, the

dietary burden for poultry and hogs are very low, 2 ppb or less. The secondary residues from

poultry and hogs consuming treated feed will be considerably lower than the currently established

tolerance. Therefore, the tolerance value for these commod ities will be used in the acute and

chronic dietary assessments. Although the Agency typically does not include FHE uses in acute

assessments, the tolerance value will be included in the acute assessment in consideration of the

secondary residues. The pe rcent crop treated will be based on the FHE uses, 5%, since these uses

will result in the highest residues.Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 59 of 60 

### Attachment 14 : Acute Critical Exposure Contribution Analysis

U.S. EPA

DEEM

- FCID Acute Critical

Exposure Contribution Analysis

(Ver. 3.16 03

- 08

- d)

NHANES 2003

- 2008 2

- Day

Residue file = C: \ Users \ KRURY \ Documents \ My Work Files \ Abamectin \ Dietary Files \ Abamectin acute Food and

Water PRIA 3 29 16.R08

Date and time of analysis: 04

- 12

- 2016 15:37:32

Daily totals for food and foodform consumption used.

Adjustment factor #2 used.

Minimum exposure contribution = 1%

MC Iterations = 1000 Seed = 10 RNG = MS VB

Exposures divided by body weight

Subpopulations:

1 Children 1

- 2

================================================================================

Children 1

- 2

Low percentile for CEC records: 99.9 Exposure (mg/day) = 0.002197

High percentile for CEC records: 100 Exposure (mg/day) = 0.004147

Number of actual records in this interval: 3132

Critical foods with foodforms for this population (as derived from these records):

N=number of appearances in all records (including duplicates)

%=percent of total exposure for all records (including duplicates)

Food FF N Percent Food Name

---------- --- ----- ------- -------------

3600224000 110 2661 52.69% Milk water

- Uncooked; Fresh or N/S;

Cook Meth N/S

9500247000 110 670 26.28% Papaya juice

- Uncooked; Fresh or N/S;

Cook Meth N/S

9500247000 240 365 5.05% Papaya juice

- Cooked; Canned;

Cook Meth N/S

3600223000 110 1854 3.98% Milk nonfat solids

- Uncooked; Fresh or

N/S; Cook Meth N/S

3100049000 210 365 3.66% Beef liver

- Cooked; Fresh or N/S; Cook

Meth N/SAbamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 60 of 60 

### 3600222000 110 1316 1.04% Milk fat

- Uncooked; Fresh or N/S; Cook

Meth N/S

1307132000 110 663 0.64% Cranberry juice

- Uncooked; Fresh or N/S;

Cook Meth N/S