**Exhibit      10.1**

|   |   | Hana                Biosciences, Inc.400                Oyster Point Boulevard, Suite 215South                San Francisco, CA 94080 |
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|   |   | Ph.                (650) 588-6404Fax.                (650) 588-2787URL:                www.hanabiosciences.com                        |

|   | 1. | **Separation                from Employment.**                The final date of your employment with the Company will be December                31,                2005 (the “Termination Date”). After the Termination Date, you and the                Company agree that you will provide consulting services to the Company,                as                described in Paragraph 4 below. As consideration for entering into                this                Agreement, the Company will pay you $5,000 on the Company’s first regular                pay day in January 2006, which payment shall be subject to applicable                income tax withholding and other legally required deductions. |
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|   | 2. | **Post-Termination                Date Consulting**.                In accordance with Section 9(d)(i) of the your Employment Agreement                dated                October 12, 2004 (the “Employment Agreement”), the Company will continue                to pay to you the annualized base salary stated in such agreement                for a                period of one (1) year following the Termination Date, which payments                will                be made in equal installments at the times of the Company’s regular                paydays. Such payments will be subject to applicable income tax                withholdings and other legally required deductions. As provided in                the                Employment Agreement, however, such payments may be offset against                any                amounts otherwise received by you from any employment during the                one (1)                year period following the termination of employment, provided, however,                that in no event shall the Company have the right to recover or offset                any                amounts paid to you pursuant to Section 9(d)(i) of the Employment                Agreement for any period prior to the commencement of new employment.                You                agree to send monthly correspondence (by email transmission to the                attention of John P. Iparraguirre, or such other representative as                the                Company may hereafter indicate) attesting to the Company your then-current                employment status and all amounts earned from any such employment. |
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|   | 3. | **Accrued                Salary and Vacation.**                On                the Termination Date, the Company will pay you all accrued salary,                and all                accrued and unused vacation, earned through the Termination Date,                subject                to standard payroll deductions and withholdings. You are entitled                to these                payments by law. In addition, on the Company’s first regular pay day in                January 2006, in addition to the payment described above in Paragraph                1,                the Company will pay you $20,000, representing a bonus for 2005,                which                payment is also subject to standard payroll deductions and                withholdings. |
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|   | **4.** | **Consulting                Services.**Following                the Termination Date, you agree to be available to the Company, on                an                as-needed basis and as mutually agreed to between the Company and                you, to                provide consulting services in the areas of corporate finance and                investor                relations. Any such services that you provide to the Company after                the                Termination Date will not be as an employee of the Company, but as                an                independent contractor. |
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|   | 5. | **Health                Insurance.**                After the Termination Date, to the extent provided by the state Cal-COBRA                law and by the Company’s current group health insurance policies, you will                be eligible to continue your group health insurance benefits at your                own                expense. |
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|   | 6. | **Other                Compensation or Benefits.**                Except as expressly provided in this Agreement, you will not receive                any                additional benefits after the Termination Date, with the sole                exception:                a)                of                any benefit to which you have a vested right under the terms of a                written,                ERISA-qualified benefit plan (*e.g.*,                401(k) plan)                ,                b) any and all rights to indemnification pursuant to California law                and                the Company’s Certificate of Incorporation and Bylaws, and c) rights as an                insured under any Company insurance policy, including but not limited                to,                Directors and Officers liability insurance policy. |
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|   | 7. | **Employment-Related                Expense Reimbursements.**                Within thirty (30)** **days                after the end of the Termination Date, you shall submit your final,                documented expense reimbursement statement reflecting all business                expenses you incurred in connection with your employment through                the                Termination Date for which you seek reimbursement. The Company will                reimburse you for these expenses pursuant to its regular business                practice. |
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|   | 8. | **Return                of Company Property.**                You agree to return to the Company, on or before the end of the                Termination Period, all documents of the Company (and all copies                or                reproductions thereof) and all other Company property in your possession                or control, including, but not limited to, all files, notes, memoranda,                correspondence, agreements, drawings, records, plans, forecasts,                reports,                proposals, studies, analyses, financial information, operational                information, personnel information, investor information, research                and                development information, computer-recorded information, tangible                property                and equipment (including, but not limited to, computers and cellular                phones), credit cards, entry cards, identification badges and keys;                and                any materials or medium of any kind which contain or embody any                proprietary or confidential information of any Company (and all                reproductions thereof, in whole or in part); *provided,                however*,                you may continue to use the Company-issued IBM ThinkPad notebook                computer                and Blackberry handheld device until the                earlier of (a) the date you commencement employment with a new employer,                or (b) December 31,                2006, at which date you agree to return such devices to the Company.                You                agree and acknowledge that, following the Termination Date, you will                be                responsible for establishing, at your own expense, wireless service                plan(s) relating to such devices. |
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|   | 9. | **Proprietary                Information Obligations.**                You will not make any use or disclosure of Company proprietary or                confidential information (whether obtained or developed during any                employment, consulting or other professional relationship with any                Company                affiliate) without written permission. In addition, you hereby assign                to                the Company, to the fullest extent permitted by law, all right, title,                and                interest in all inventions, techniques, processes, materials, and                other                intellectual property developed by you, alone or with others, in                the                course of your employment with the Company. This                Agreement does not apply to an invention which qualifies fully as                a                nonassignable invention under Section 2870 of the California Labor                Code.                By your signature below, you acknowledge that you have reviewed the                Limited Exclusion Notification attached hereto as Exhibit A. You                further                acknowledge that all original works of authorship which are made                by you                (solely or jointly with others) within the scope of your employment                with                the Company and which are protectable by copyright are “works made for                hire,” pursuant to United States Copyright Act (17 U.S.C., Section                101). |
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|   | 10. | **Confidentiality.**                The provisions of this Agreement (with the exception of the fact                of your                employment) will be held in strictest confidence by you and the Company                and will not be publicized or disclosed in any manner whatsoever;                *provided,                however,*                that: (a) you may disclose this Agreement in confidence to your immediate                family; (b) the parties may disclose this Agreement in confidence                to their                respective attorneys, accountants, auditors, tax preparers, and financial                advisors; (c) the Company may disclose this Agreement to investors                and as                necessary to fulfill standard or legally required corporate reporting                or                disclosure requirements, including applicable provisions of the federal                securities laws; and (d) the parties may disclose this Agreement                insofar                as such disclosure may be necessary to enforce its terms or as otherwise                required by law. In particular, and without limitation, you agree                not to                disclose the terms of this Agreement to any current or former employee                of                the Company. |
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|   | 11. | **Nondisparagement.**                You agree not to disparage the Company and its officers, directors,                members, partners, managers, employees, shareholders, affiliates,                and                agents, in any manner likely to be harmful to them or their business,                business reputation or personal reputation. The Company agrees not                to                disparage you in any manner likely to be harmful to you or your business                reputation. Notwithstanding the foregoing, both you and the Company                may                respond accurately and fully to any question, inquiry or request                for                information when required by legal                process. |
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|   | 12. | **Acts                Necessary To Effect This Agreement.**You                and the Company                agree to execute any instruments or agreements (or amendments thereto),                or                perform any other acts that are or may become, necessary to effect                and                carry out the transactions contemplated by this                Agreement. |
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|   | 13. | **Release                of Claims.**Except                as otherwise set forth in this Agreement, in exchange for the                consideration under this Agreement to which you would not otherwise                be                entitled, you hereby generally and completely release the Company                and its                directors, officers, employees, shareholders, attorneys, insurers,                affiliates and assigns,** **from                any and all claims, liabilities and obligations, both known and unknown,                that arise out of or are in any way related to events, acts, conduct,                or                omissions occurring at any time prior to or contemporaneous with                your                execution of this Agreement. This general release includes, but is                not                limited to: (a) all claims arising out of or in any way related to                your                employment or other professional relationship with the Company or                the                termination of that employment or relationship; (b) all claims related                to                your compensation or benefits, including salary, bonuses, commissions,                vacation pay, expense reimbursements, severance pay, fringe benefits,                stock, or stock options; (c) all claims for breach of contract, wrongful                termination, and breach of the implied covenant of good faith and                fair                dealing; (d) all tort claims, including claims for fraud, defamation,                emotional distress, and discharge in violation of public policy;                and (e)                all federal, state, and local statutory claims, including claims                for                discrimination, harassment, retaliation, attorneys’ fees, or other claims                arising under the federal Civil Rights Act of 1964 (as amended),                the                federal Americans with Disabilities Act of 1990 (as amended), the                federal                Age Discrimination in Employment Act (“ADEA”) (as amended), and the                California Fair Employment and Housing Act (as amended). Nothing                in this                release shall apply to any claims by you against the Company relating                to                your vested rights to Company stock options, 401(k) benefits or any                benefits set forth in Paragraph 6. |
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|   | 14. | **ADEA                Waiver.**You                acknowledge that you are knowingly and voluntarily waiving and releasing                any rights you may have under the ADEA, and that the consideration                given                for the waiver and release in the preceding paragraph hereof is in                addition to anything of value to which you were already entitled.                You                further acknowledge that you have been advised that: (a) your waiver                and                release do not apply to any rights or claims that may arise after                the date                you sign this Agreement; (b) you should consult with an attorney                prior to                signing this Agreement (although you may choose not to do so); (c)                you                have twenty-one (21) days to consider this Agreement (although you                may                choose voluntarily to sign this Agreement earlier); (d) you have                seven (7)                days following the date you sign this Agreement to revoke your consent                to                the Agreement by providing written notice of your revocation to me;                and                (e) this Agreement will not be effective until the date upon which                the                revocation period has expired, which will be the eighth day after                the date                you sign this Agreement (the “Effective Date”). |
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|   | 15. | **Section                1542 Waiver.**                In                giving the release set forth in this Agreement, which includes claims                which may be unknown to you at present, you acknowledge that you                have read                and understand Section 1542 of the California Civil Code which reads                as                follows: |
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**A      general release does not extend to claims, which the creditor does not know      or      suspect to exist in his favor at the time of executing the release, which if      known by him must have materially affected his settlement with the      debtor.**

|   | 16. | **Section                1541 Notice.**                This Agreement is in full accord, satisfaction, and discharge of                doubtful                and disputed claims and this Agreement has been executed with the                express                intention of effectuating the legal consequences provided for in                Section                1541 of the California Civil Code, i.e., the extinguishment of all                obligations as described herein. I have had the opportunity to have                this                section explained to me by legal counsel and I fully understand it.                Section 1541 provides as follows: |
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**An      obligation is extinguished by a release therefrom given to the debtor by the      creditor, upon a new consideration, or in writing, with or without new      consideration.**

|   | 17. | **No                Admissions.**You                understand and agree that the promises and payments in consideration                of                this Agreement shall not be construed to be an admission of any liability                or obligation by any Company Affiliate to you or to any other person,                and                that the Company make no such admission. |
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|   | 18. | **Arbitration.**                To                ensure the timely and economical resolution of any disputes which                may                arise under this Agreement, you and the Company agree that any and                all                claims, disputes or controversies of any nature whatsoever arising                from or                regarding the interpretation, performance, negotiation, execution,                enforcement or breach of this Agreement shall be resolved, to the                fullest                extent allowed by law, by confidential, final and binding arbitration                conducted before a single arbitrator with Judicial Arbitration and                Mediation Services, Inc. (“JAMS”) in San Francisco, California, under the                then-applicable JAMS rules. **The                parties** **acknowledge                that by agreeing to this arbitration procedure, they waive the right                to                resolve any such dispute through a trial by jury, judge or administrative                proceeding**.                The Company shall bear JAMS’ arbitration fees in excess of the amount of                court fees that would be required if the dispute were decided in                a court                of law. The arbitrator shall: (a) have the authority to compel adequate                discovery for the resolution of the dispute and to award such relief                as                would otherwise be permitted by law; and (b) issue a written arbitration                decision including the arbitrator’s essential findings and conclusions and                a statement of the award. The arbitrator, and not a court, shall                also be                authorized to determine whether the provisions of this paragraph                apply to                a dispute, controversy or claim sought to be resolved in accordance                with                these arbitration procedures. Nothing in this Agreement is intended                to                prevent either you or the Company from obtaining injunctive relief                in                court to prevent irreparable harm pending the conclusion of any such                arbitration. |
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|   | 19. | **Miscellaneous.**  |
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| **(a)** | **Severability.**                    Whenever possible, each provision of this Agreement will be interpreted                    in                    such manner as to be effective and valid under applicable law,                    but if any                    provision of this Agreement is held to be invalid, illegal or                    unenforceable in any respect, in whole or in part, such invalidity,                    illegality or unenforceability will not affect any other provision,                    and                    such invalid, illegal or unenforceable provision will be reformed,                    construed and enforced so as to render it valid, legal, and enforceable                    consistent with the intent of the parties insofar as possible                    under                    applicable law. |
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| **(b)** | **Waiver.**                    Any waiver of any breach of any provision of this Agreement shall                    be in                    writing, and the waiving party shall not thereby be deemed to                    have waived                    any preceding or succeeding breach of the same or any other provision                    of                    this Agreement. |
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| **(c)** | **Entire                    Agreement.**                    This Agreement, including its exhibits, constitutes the final,                    complete,                    and exclusive embodiment of the entire agreement between you                    and the                    Company regarding the subject matter hereof and it supersedes                    any prior                    agreement, promise, or representation, written or otherwise,                    between you                    and any of the Company with regard to this subject matter. To                    the extent                    that the provisions of this Agreement are inconsistent with the                    provisions                    of the other agreements specified herein, this Agreement shall                    govern;                    *provided,                    however,*that                    to the extent not inconsistent with this Agreement, the other                    agreements                    shall continue in full force and effect. This Agreement is entered                    into                    without reliance on any agreement, promise, or representation,                    written or                    oral, other than those expressly contained or incorporated herein,                    and it                    cannot be modified or amended except in a written agreement signed                    by you                    and me. |
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| **(d)** | **Counterparts.**                    This Agreement may be executed in separate counterparts, any                    one of which                    need not contain signatures of more than one party, but all of                    which taken                    together shall constitute one and the same Agreement. Signatures                    transmitted via facsimile shall be deemed the equivalent of                    originals. |
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| **(e)** | **Headings                    and Construction.**                    The headings of the paragraphs hereof are inserted for convenience                    only                    and shall not be deemed to constitute a part hereof or to affect                    the                    meaning thereof. For purposes of construction of this Agreement,                    any                    ambiguities shall not be construed against either party as the                    drafter. |
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| **(f)** | **Successors                    and Assigns.**                    This Agreement is intended to bind and inure to the benefit of                    and be                    enforceable by you, the Company and your and its respective successors,                    assigns, heirs, executors and administrators, except that you                    may not                    assign any of your duties or rights hereunder without the written                    consent                    of the Company, which shall not be unreasonably                    withheld. |
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| **(g)** | **Governing                    Law.**                    All questions concerning the construction, validity and interpretation                    of                    this Agreement shall be governed by the law of the State of California                    as                    applied to contracts made and to be performed entirely within                    the State of                    California. |
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**Hana          Biosciences**

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| By:    | /s/ Mark                  J. Ahn                     |   |   |   |
|   | Mark J. Ahn, Ph.D.President & Chief Executive Officer |   |   |        |

**Exhibit          A - Limited Exclusion Notification**

**Accepted          And Agreed:**

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| /s/ Russell                    L. Skibsted |   |   |   |
| Russell                  L. Skibsted            |   |   |        |
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| December                    28, 2005       |   |   |   |
| Date                                            |   |   |   |

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