RR Case Name PC Code s CAS #

Diethylene G lycol Monometh yl Ether 042204 111

- 77

- 3

TABLE OF CONTENTS P AGE No.

DIETHYLENE GLYCOL MONOMETHYL ETHER

.................. 2

APPENDICES

------------------------------------------------------------- ------- 7

REGISTRATION REVIEW DOCUMENT

PRODUCT CHEMISTRY, ENVIRO NMENTAL FATE AND

ECOLOGICAL EFFECTS SUMMARY FOR DIETHYLENE GLYCOL

MONOMETHYL ETHER

PCCo de: 042204 Case No. 5010

Chemical name Use patterns/use sites

Diethylene Glycol Monomethyl

Ether Used i n Liquid hydrocarbon fuels,

an antimicrobial and anti

- ic ing (de

icer) control (0.10

- 0.15 % by

volume)

Regulatory History:

Table 1: Registered Active Products for Diethylene Glycol Monomethyl Ether

EPA Reg.

Number Product Name Formulation

Type % Active

Ingredient Registrant

224

- 32 Phillips Fuel

A dditive 5 6 MB Petroleum

Distillate 99.7 Phillips 66 Company/ a

Subsidiary of Phillips

Petroleum Company

Table 2. Chemical Identity

Common Name Diethylene Glycol Monomethyl Ether

Chemical Name 2

- (2

- Methoxyethoxy) ethanol

IUPAC Name 2

- (2

- Methoxyethoxy)ethanol

Molecular Weight 120.15Table 2. Chemical Identity

PC Code 011504

CAS Registry Number 111

- 77

- 3

Molecular Formula

/Empirical

Formula C 5 H 12 O 3

Registration Review Case No. 5010

Registration Review Case Name Diethylene Glycol Monomethyl Ether

Classification: Organic

Structures :



## CH 3 

## – (O

- CH 2 

## - CH 2 

## ) 2 

## - OH

Science Findings:

Data are summarized for each discipline in the following sections:

Product Chemistry Summary

Table 3: Physical and Chemical Properties of Diethylene Glycol Monomethyl Ether

Guideline

No. Physical and Chemica l Properties Value

830.1550 Product identity and composition Refer to Table 2

830.1600 Description of materials used to

produce the product Cbi

830.1620 Description of production process Cbi

830.1650 Description of formulation process Cbi

830.1670 Dis cussion of formation of impurities Cbi

830.1700 Preliminary analysis Cbi

830.1750 Certified limits Cbi

830.1800 Enforcement analytical method Cbi

830.1900 Submittal of samples Cbi

830.6302 Color Transparent :

830.6303 Physical State Liquid

830.6304 O dor Mild :

830.6313 Stability to sunlight, normal and

elevated temperature N A

830.6314 Oxidation/Reduction: Chemical

Incompatibility No redox properties

830.6315 Flammability

Flash Point ~ 80 o C

830.6316 Explodability NA

830.6317 Storage Stability St able

830.6319 Miscibility 100% at 20 o C

830.6320 Corrosion Characteristic Non

- corrosiveGuideline

No. Physical and Chemica l Properties Value

830.6321 Dielectric breakdown voltage NA

830.7000 pH 5

- 8.5

830.7050 UV/Visible absorption spectra No absorption in UV range;

830.7100 Viscosity 3.9 centipoise

830.7200 Melting Point NA

830.7220 Boiling point 193 o C

830.7300 Density / Bulk density 1.035 g/cc

830.7370 Dissociation Constants in water NA

830.7520 Particle size NA

830.7550 Octanol/water partition coefficient

(K OW ) (Log K

ow ) - 1.18 (EPI SUIT E)

830.7840 Solubility in water Highly miscible

830

- 7840 Solubility in organic solvents in g/100

ml Highly miscible in alcohol, ether, and acetone

830.7950 Vapor pressure 0.25 mm Hg at 25 o C

Environme ntal Fate and Transport Data Summary :

Followi ng fate related parameters for DGME are obtained from US EPA’s EPI SUITE

Program:

1. Vapor P ressure: 0.25 mm Hg at 25 C

2. Log Kow:

- 1.81 (estimated)

3. Henry Law Constant(HLC): 6.5 x 10

- 10 atm m 3 /mol

4. Ready Biodegradability: it is readily biodegradable

5. Under anaer obic conditions: it is not readily biodegradable

6. Half life in air: 4.93 hours (estimated)

7. Koc: 1 L/Kg

8. In Wastewater Treatment P lant: Total removal in sludge: <2%

Environmental Fate and Transport Conclusions :

There are no d a ta generated based on the enviro nmental fate test guidelines series 161 .

Ho w ever some important fate param e ters are available in literature, some measured, and

some estimated as listed above. Based on these fate characteristics:

DGME is highly volatile substance and easily transfer into the atmosphere; however, its

half life in air is short (4.93 hours) , and is likely to degrade easily. It is highly water

soluble, and under ae robic conditions it can undergoes ready biodegradation..

Its Koc is small (~ 1 L/Kg) and it will migrate from s ur face soil to ground water easily ;

however, it is likely to biodegrade over a period of time.

Estimated log Kow (

- 1.81) is negligible, and it is not likely to bioaccumulate in aquatic

organisms, and there are no eco risk concerns for aquatic organisms t hrough the DGME

expo sure, and for the use pattern at this time.Environmental Fate and Transport Data Gaps

At this time the Agency does not anticipate requiring additional fate data for the present

use and use scenario.

Ecological Effects Data Summary :

Table 4 summarizes the eco

- effects data.

Table 4

Ecotoxicity Data

Guideline #/Study

type MRID#/ Classification Dosing/Organism

Information Results

850.1010: Aquatic

Invertebrate Acute

Toxicity MRID#: 45719201:

Guideline: Core Daphnia magna

Purity: 99.9% 48 hour EC50:

930 mg a.i./L

NOAEC: 930 mg

a.i./L

850.1075

Fish Acute

Toxicity MRID#: 4519202:

Guideline: Core Rainbow Trout;

Purity: 99.9% 96 hr LC50:>960

mg a.i./L;

NOAEC: 960 mg

a.i./L

850.1075: Acute

Toxicity to

Estuarine/Marin e

Organisms MRID#: 43945608 Test substance

administered at

5,000 and 10,000

ppm

Bluegill sunfish

Purity not reported LC50: 7,500 ppm

0% survival after

48 hours at

10,000 ppm

100% survival

after 96 hours at

5,000 ppm

850.2100: Avian

Acute Oral

Toxicity MRI D# 45325101:

Guideline: Core Northern bobwhite

Purity: 99.7% LD50> 2250

mg/kg

(determined by

visual inspection)

NOAEL: 2250

mg/kg

Hazard and Risk Concl usions

Some of these studies are submitted studies, and some were acquired from open

literature an d or ECOTOX database. These studies have not been reviewed and assessed

by the Agency. For the present use, the Agency has not conducted any hazard

assessment.

However, the available ecotoxicity data categorize technical grade DGME as being

practically no n

- toxic to birds and aquatic organisms. The Agency will conduct hazard

risk assessment based on the data listed in Table 4, and also after review and assessment

of the algal toxicity study data (850.5400)Ecotoxicity Data Gaps:

The Agency will requi re the following ecotoxicity study.

850. 5400: Algal Toxicity Study (Tier II)

BIBLIOGRAPHY FOR: PRODUCT CHEMISTRY, ENVIRONMENTAL FATE

AND TRANSPOR T, AND ECO

- TOXICITY

1. MRID#: 45719201: Machado, M (2002); Phillips Fuel Additive 56 MB:

Acute Toxicity t o Water Fleas (Daphnia Magna) U nder Flow Through

Conditions; Lab Project #: 13695.6118, unpublished study, submitted by:

Springborn Smithers Labs, 56 p ages

2. MRID# 4519202: Mac h a do, M (2002): Phillips fuel Additives/ 56 MB: Acute

Toxicity to Rainbow Trout Un der Flow Through Conditions; Lab Project#:

13695.6119; unpublished study prepared by Springborn Smithers Labs, 55

pages.

3. MRID#: 4394608, Dowson, G, et al (1976): The Acute Toxicity of 47

Industrial Chemicals to Fresh and Saltwater Fishes: Journal of hazar dous

Materials, 1: pp 308

- 318

4. MRID#: 45325101: Gallaghe r et al. (2000), PFA 56 MB: An A cute Oral

Toxicity Study with Bobwhite ; Lab Project #: 251

- 110; unpublished study by

Wild Life International, Ltd, 29 pages.

5. EPI SUITE, Version 4.0