Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM 

Date: 04/14/2016

SUBJECT: Abamectin: PP# 4E8309, 3E8175, and 3F8184 Acute and Chronic Aggregate 

Dietary (Food and Drinking Water) Exposure and Risk Assessments for Section 3 

Registration Actions for Four Separate New Use Actions and Tolerance Petitions: 

(1) New Uses on Bean, Papaya, Star Apple, Black Sapote, Sapodilla, Canistel, 

Mamey Sapote, Guava, Feijoa, Jaboticaba, Wax Jambu, Starfruit, Passionfruit, 

Acerola, Lychee, Longan, Spanish Lime, Rambutan, Pulasan, Pineapple; Onion, 

Green, Subgroup 3-07B; Fruit, Pome, Group 11-10; Fruit, Small Vine Climbing, 

except Fuzzy Kiwifruit, Subgroup 13-07F; Berry, Low Growing, Subgroup 13-

07G; and Conversion of Existing Crop Groups to Vegetable, Fruiting, Group 8-10 

(and Addition of Greenhouse-grown Tomato); Fruit, Citrus, Group 10-10; Fruit, 

Stone, Group 12-12; and Nut, Tree, Group 14-12. (2) New Uses on Caneberry 

Subgroup 13-07A. (3) Sweet Corn and Soybeans. And (4) Cattle Ear Tag on 

Lactating Cattle. 

 PC Code: 122804 DP Barcode: D424009, D421348

 Decision Nos.: 495169, 480190, 476238, 

478520

Registration Nos.: 100-1154, 100-1351, 100-1408, and 

100-1439, 100-898, 100-1350, and 39039-17

 Petition Nos.: 4E8309, 3E8175, 3F8184 Regulatory Action: Section 3 Registration

 Risk Assessment Type: Dietary Case No.: 7430

 TXR No.: NA CAS No.: 71751-41-2

 MRID No.: NA 40 CFR: §180.449

FROM: Nancy Dodd, Chemist

Kristin Rickard, Biologist

Risk Assessment Branch III (RAB3)

Health Effects Division (HED) (7509P)

THROUGH: Julie VanAlstine, DESAC Reviewer 

Doug Dotson, DESAC Reviewer

And 

Christine Olinger, Branch Chief

RAB3/HED (7509P)
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TO: Laura Nollen, Biologist

RAB3/HED (7509P)

and

Mark Suarez/Jessica Rogala, RM#1

Registration Division (7505P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity 

Intake Database (DEEM-FCID), Version 3.16. This software uses 2003-2008 food consumption 

data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition 

Examination Survey, What We Eat in America (NHANES/WWEIA). The analyses were 

conducted in support of a human health risk assessment for three separate petitions for the 

insecticide/miticide, abamectin: 

• 4E8309: The Interregional Project No. 4 (IR-4) has proposed a Section 3 registration of 

abamectin on bean, papaya, star apple, black sapote, sapodilla, canistel, mamey sapote, 

guava, feijoa, jaboticaba, wax jambu, starfruit, passionfruit, acerola, lychee, longan, 

Spanish lime, rambutan, pulasan, pineapple; onion, green, subgroup 3-07B; fruit, pome, 

group 11-10; fruit, small vine climbing, except fuzzy kiwifruit, subgroup 13-07F; berry, 

low growing, subgroup 13-07G; and conversion of existing crop groups to vegetable, 

fruiting, group 8-10 (and addition of greenhouse-grown tomato); fruit, citrus, group 10-10; 

fruit, stone, group 12-12; and nut, tree, group 14-12. 

• 3E8175: IR-4 has proposed a Section 3 registration of abamectin on caneberry subgroup 

13-07A. 

• 3F8184: Syngenta Crop Protection (Syngenta) has proposed a Section 3 registration of 

abamectin in/on sweet corn and soybeans. 

In addition, the registrant Y-TEX Corporation, submitted a Section 3 request for a cattle ear tag 

containing abamectin for use on lactating cattle. An ear tag use has been registered on beef cattle 

and non-lactating dairy cattle. 

This memorandum was reviewed by two peer reviewers of the DESAC (Julie VanAlstine and 

Doug Dotson), per DESAC Standard Operating Procedure (SOP) 2012.1 and was discussed by the 

DESAC on April 14, 2016. 

Acute Dietary (Food and Drinking Water) Exposure Assessment

A refined acute dietary (food and drinking water) exposure assessment was conducted for all 

proposed and established food uses of abamectin. Acute anticipated residues derived from field 

trial data were used. Empirical and default processing factors and percent crop treated (% CT) 

estimates were used, as available. Surface drinking water concentrations were estimated using the 

Tier II surface water concentration calculator (SWCC) computer model. The model predicts that 
Abamectin Dietary Exposure Assessment D424009, D421348

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the maximum concentration of total residues of abamectin in surface water (the 1-in-10-year peak 

exposure) is not likely to exceed 0.76 ppb from the proposed uses. A residue distribution file of 

estimated drinking water concentrations (EDWCs) from the Environmental Fate and Effects 

Division (EFED) was used in the acute assessment. 

The acute dietary exposure estimates for food and drinking water are not of concern (<100% 

aPAD) at the 99.9th percentile of exposure for the general U.S. population and all population 

subgroups. Abamectin dietary exposure at the 99.9th percentile for food and drinking water is 45%

of the aPAD for the general U.S. population and 88% of the aPAD for children 1-2 years old, the 

most highly exposed population subgroup. 

Chronic Dietary (Food and Drinking Water) Exposure Assessment

A refined chronic dietary (food and drinking water) exposure assessment was conducted for all 

proposed and established food uses of abamectin. Average residues from field trials were used. 

Residues from use in food handling establishments were included. Empirical and default 

processing factors and % CT estimates were used, as available. Drinking water was represented 

by a single point estimate of average abamectin residues (the 1-in-10-year annual mean). The 

estimated surface water concentration of 0.30 ppb was based on the application to beans.

The chronic dietary exposure estimates for food and drinking water are not of concern (<100% 

cPAD) for the general U.S. population and all population subgroups. Abamectin dietary exposure 

for food and drinking water is 2.2% of the cPAD for the general U.S. population and 11% of the 

cPAD for children 1-2 yrs old, the most highly exposed population subgroup.

Cancer Dietary (Food and Drinking Water) Exposure Assessment

Since abamectin is classified as “not likely to be carcinogenic to humans,” a cancer dietary 

exposure assessment is not required.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., 

the dose that HED has concluded will result in no unreasonable adverse health effects). This dose 

is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of 

departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more 

detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2007-0780-0001; or see SOP 

99.6 (20-AUG-1999).
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The most recent dietary risk assessment for abamectin was conducted in 2014 (N. Dodd, , 

D421348, 10/28/2014).

II. Residue Information

Tolerances have been established in 40 CFR §180.449(a) for residues of abamectin (avermectin), 

including its metabolites and degradates, in or on various plant and livestock commodities at levels 

ranging from 0.005 to 1.0 ppm, and for use in food handling establishments at 0.01 ppm. 

Compliance with the tolerance levels is to be determined by measuring only avermectin B1 [a 

mixture of avermectins containing greater than or equal to 80% avermectin B1a (5-O-demethyl 

avermectin A1) and less than or equal to 20% avermectin B1b (5-O-demethyl-25-de(1-

methylpropyl)-25-(1-methylethyl) avermectin A1)] and its delta-8,9-isomer. 

The Interregional Research Project No. 4 (IR-4), on behalf of the Agricultural Experiment Stations 

of California (CA), Delaware (DE), Florida (FL), Hawaii (HI), Oregon (OR), Puerto Rico (PR), 

South Carolina (SC), and Tennessee (TN) proposed establishment of tolerances for new uses on 

bean, papaya, star apple, black sapote, sapodilla, canistel, mamey sapote, guava, feijoa, jaboticaba, 

wax jambu, starfruit, passionfruit, acerola, lychee, longan, Spanish lime, rambutan, pulasan, 

pineapple; onion, green, subgroup 3-07B; fruit, pome, group 11-10; fruit, small vine climbing, 

except fuzzy kiwifruit, subgroup 13-07F; berry, low growing, subgroup 13-07G; and conversion of 

existing crop groups to vegetable, fruiting, group 8-10 (and addition of greenhouse-grown tomato); 

fruit, citrus, group 10-10; fruit, stone, group 12-12; and nut, tree, group 14-12. Syngenta Crop 

Protection LLC (Syngenta) has submitted PP# 3F8184 to request the establishment of permanent 

tolerances for residues of abamectin on sweet corn commodities (forage, kernel plus cob with husk 

removed, and stover) and soybean commodities (forage, hay, and seed). The Interregional 

Research Project No. 4 (IR-4), on behalf of the Agricultural Experiment Stations of Arkansas 

(AR), CA, DE, North Carolina (NC), SC, and Washington (WA) has submitted pesticide petition 

(PP#) 3E8175 to request the establishment of permanent tolerances for residues of abamectin on 

Caneberry subgroup 13-07A. 

Finally, Y-TEX Corporation has requested registration of an ear tag containing abamectin and 

piperonyl butoxide for use on lactating dairy cattle. An ear tag use has been registered on beef 

cattle and non-lactating dairy cattle. Tolerances for abamectin on fat, meat, and meat byproducts of 

cattle were previously increased to reflect that use. This review concerns residues in milk. No 

increase in the tolerance on milk was proposed. This review concerns only abamectin; piperonyl 

butoxide has been under separate review.

HED is recommending for the establishment of the following permanent tolerances. 

Acerola ..................................................................................................0.015 ppm

Bean.......................................................................................................0.015 ppm

Berry, low growing, subgroup 13-07G ..................................................0.05 ppm

Black sapote ...........................................................................................0.40 ppm
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Caneberry subgroup 13-07A ..................................................................0.20 ppm

Canistel...................................................................................................0.40 ppm

Cattle, fat ................................................................................................0.05 ppm

Cattle, meat.............................................................................................0.02 ppm

Cattle, meat byproducts..........................................................................0.09 ppm

Corn, sweet, forage.................................................................................0.20 ppm

Corn, sweet, kernel plus cob with husk removed...................................0.01 ppm

Corn, sweet, stover.................................................................................0.50 ppm

Feijoa .....................................................................................................0.015 ppm

Fruit, citrus, group 10-10........................................................................0.02 ppm

Fruit, pome, group 11-10........................................................................0.02 ppm

Fruit, stone, group 12-12 ........................................................................0.09 ppm

Fruit, small vine climbing, except fuzzy kiwifruit, subgroup 13-07F....0.02 ppm

Goat, fat..................................................................................................0.03 ppm

Goat, meat ..............................................................................................0.02 ppm

Goat, meat byproducts............................................................................0.04 ppm

Grain, aspirated grain fractions..............................................................0.40 ppm

Guava.....................................................................................................0.015 ppm

Hog, fat...................................................................................................0.01 ppm

Hog, meat ...............................................................................................0.02 ppm

Hog, meat byproducts.............................................................................0.02 ppm

Horse, fat ................................................................................................0.03 ppm

Horse, meat.............................................................................................0.02 ppm

Horse, meat byproducts..........................................................................0.04 ppm

Jaboticaba ..............................................................................................0.015 ppm

Longan....................................................................................................0.01 ppm

Lychee ....................................................................................................0.01 ppm

Mamey sapote.........................................................................................0.40 ppm

Milk .......................................................................................................0.015 ppm

Nut, tree, group 14-12 ............................................................................0.01 ppm

Onion, green, subgroup 3-07B ...............................................................0.08 ppm 

Papaya ....................................................................................................0.40 ppm

Passionfruit............................................................................................0.015 ppm

Pineapple ...............................................................................................0.015 ppm

Poultry, meat ..........................................................................................0.02 ppm

Poultry, meat byproducts........................................................................0.02 ppm

Pulasan....................................................................................................0.01 ppm

Rambutan................................................................................................0.01 ppm

Sapodilla.................................................................................................0.40 ppm

Sheep, fat................................................................................................0.03 ppm

Sheep, meat ............................................................................................0.02 ppm

Sheep, meat byproducts..........................................................................0.04 ppm

Soybean, forage ......................................................................................0.30 ppm

Soybean, hay ...........................................................................................1.0 ppm
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Soybean, seed .........................................................................................0.01 ppm

Spanish lime ...........................................................................................0.01 ppm

Star apple................................................................................................0.40 ppm

Starfruit..................................................................................................0.015 ppm

Vegetable, fruiting, group 8-10 ..............................................................0.07 ppm

Wax jambu ............................................................................................0.015 ppm

The nature of the residue in plants and livestock is adequately understood. The residues of 

concern (ROCs) for the risk assessment are avermectin B1a, avermectin B1b, and their delta-8,9-

isomers (also known as 8,9-Z isomers).

The drinking water assessment provides screening-level EDWCs of the residues of concern, which 

include abamectin and the structurally similar degradates, NOA 448111, NOA 448112, NOA 

426289, NOA 445495, NOA 457464, and NOA 457465 (G. Orrick, D412861, 5/15/2014).

EPA is now including residues in fish/catfish in the dietary exposure assessment if they are 

reported by the USDA Pesticide Data Program (PDP). PDP monitored pesticide residues in catfish 

in 2008, 2009, and 2010 and in salmon in 2013 and 2014; however, the samples were not analyzed 

for abamectin or avermectin. As a result, PDP residues in fish were not included in this 

assessment. 

 

Data Used for Acute Assessment:

Anticipated residues based on field trials were used for agricultural commodities. Tolerance-level 

residues were used for livestock commodities except for milk, for which the calculated residue 

value of 0.011 ppm was used instead of the tolerance of 0.015 ppm. The SOP for field trial data 

(HED SOP 2000.1) was used to translate residue data from representative crops of crop groups to 

other members of the crop groups. For livestock commodities, residue distribution files were used 

based on tolerance-level residues, maximum percent crop treated, and the maximum residue for 

the feed items. (Refer to the Anticipated Residues Summary Table, Attachment 1, the Acute 

Residue Distribution Files, Attachment 2, and The Calculation of Livestock Anticipated Residues, 

Attachment 13.) No monitoring data were used. The % CT data provided by BEAD in 2015

(“Updated Screening Level Usage Analysis (SLUA) Report for Abamectin, PC Code 122804,” No 

DP Number, J Alsadek, 7/1/2015 and “Percent Crop Treated for Abamectin (122804) on IR4 

Proposed New Use on Caneberries and New Foliar Use on Soybeans and Sweet Corn,” D428074, 

D Atwood, 8/27/2015) were used. (Refer to Attachment 12 for tabulated percent crop treated 

data.) Empirical processing factors generated in processing studies were used for apple juice 

(0.073x), chive, dried leaves (2.9x), grape juice (0.47x), raisin (0.75x), citrus oil (9.7x), grapefruit 

juice (0.85x), other citrus juices (0.25x), peel of lemon and orange (2.5x), dried prune (3.9x), 

tomato juice (0.21x), tomato paste (1.2x), and tomato puree (0.40x). The available DEEM 7.81 

default processing factors were used for commodities for which empirical processing factors are 

not available.
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Data Used for Chronic Assessment:

Average field trial residue levels were used for agricultural commodities. Tolerance-level residues 

were used for livestock commodities except for milk, for which the calculated residue value of 

0.011 ppm was used instead of the tolerance of 0.015 ppm. The SOP for field trial data (HED SOP 

2000.1) was used to translate residue data from representative crops of crop groups to other 

members of the crop groups. 

Abamectin residues in food handling establishments were reported as <0.001 ppm, the stated LOQ 

of the method (D283818, J. Morales, 11/20/2003; D310414, N. Dodd, 12/1/2004). For 

commodities which could be exposed only in food handling establishments, a value of 1⁄2 LOD 

(0.0002 ppm) was assigned (D283818, J. Morales, 11/20/2003). If any commodity residue value 

was less than the food handling establishment (FHE) value, then 1⁄2 LOD (0.0002 ppm) was used. 

For commodities assigned the FHE value, the processing factor was set to 1 and the % CT was set 

to 5% (DP# 413125, J. Becker, 10/7/2014). (Refer to the Anticipated Residues Summary Table, 

Attachment 1, and the Chronic Point Estimates, Attachment 2.) No monitoring data were used. 

The % CT data provided by BEAD in 2015 (cited above) were used for the agricultural 

commodities (i.e., the non-FHE uses). 

Empirical processing factors generated in processing studies were used for apple juice (0.073x), 

chive, dried leaves (2.9x), grape juice (0.47x), raisin (0.75x), citrus oil (9.7x), grapefruit juice 

(0.85x), other citrus juices (0.25x), peel of lemon and orange (2.5x), dried prune (3.9x), tomato 

juice (0.21x), tomato paste (1.2x), and tomato puree (0.40x). The available DEEM 7.81 default 

processing factors were used for commodities for which empirical processing factors are not 

available.

For livestock commodities, residue levels are based on the maximum reasonable dietary burden for 

secondary residues in livestock and the highest residue found in the magnitude of residue studies 

for cattle ear tags. The percent crop treated for livestock commodities is based on the PCT value 

for the livestock feed item used in the dietary burden with the highest percent crop treated. The 

dietary burden estimates were higher for dairy cattle than beef cattle, sweet corn forage PCT 

estimates were the highest of the PCT estimates for feed items used in the diet (a maximum of 

57% for acute estimates, and 45% for chronic/background estimates). The dietary burden 

estimates were very low for poultry and swine (as noted in Attachment 13), which would result in 

secondary residues considerably lower than the current tolerances that are based on the FHE use. 

Therefore, tolerance values were used for poultry and swine, and the PCT for FHE was used. The 

PCT values for poultry and swine feed items were not used, as they would lead to an overestimate 

of exposure. Although residues from FHE are not usually used in an acute exposure assessment, 

the tolerance levels for poultry and swine were used to account for poultry and swine consuming 

treated feed.
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III. Percent Crop Treated Information

As tabulated in Attachment 12, the following maximum percent crop treated estimates provided by 

BEAD (No DP Number, J Alsadek, 7/1/2015 and D428074, D Atwood, 8/27/2015) were used in 

the acute dietary risk assessment for the following crops for abamectin: almond: 80%; apple: 30%; 

apricot: 30%; avocado: 60%; bean, dry: 2.5%; blackberry: 68%; boysenberry: 68%; cantaloupe: 

45%; celery: 70%; cherry: 20%; corn, sweet: 57%; cotton: 30%; cucumber: 10%; grape: 35%; 

grapefruit: 90%; hazelnut: 2.5%; honeydew: 35%; lemon: 55%; lettuce: 45%; loganberry: 68%; 

nectarine: 20%; onion, bulb: 10%; orange: 70%; peach: 25%; pear: 85%; pecan: 2.5%; pepper: 

30%; pistachio: 2.5%; plum/prune: 35%; potato: 20%; pumpkin: 10%; raspberry: 68%; soybean: 

11%; spinach: 45%; squash: 15%; strawberry: 45%; tangerine: 55%; tomato: 25%; walnut: 55%; 

and watermelon: 15%. 

The following average percent crop treated estimates provided by BEAD (No DP Number, J 

Alsadek, 7/1/2015 and D428074, D Atwood, 8/27/2015) were used in the chronic dietary risk 

assessment for the following crops for abamectin: almond: 70%; apple: 10%; apricot: 15%; 

avocado: 35%; bean, dry: 2.5%; blackberry: 56%; boysenberry: 56%; cantaloupe: 25%; celery: 

45%; cherry: 5%; corn, sweet: 45%; cotton: 20%; cucumber: 5%; grape: 15%; grapefruit: 70%; 

hazelnut: 2.5%; honeydew: 20%; lemon: 40%; lettuce: 20%; loganberry: 56%; nectarine: 20%; 

onion, bulb: 2.5%; orange: 40%; peach: 10%; pear: 70%; pecan: 1%; pepper: 15%; pistachio:

2.5%; plum/prune: 10%; potato: 5%; pumpkin: 5%; raspberry: 56%; soybeans: 8%; spinach: 25%; 

squash: 5%; strawberry: 30%; tangerine: 35%; tomato: 10%; walnuts: 25%; and watermelons: 5%.

All commodities included for food handling residues were assigned the value of 5% CT (DP# 

413125, J. Becker, 10/7/2014). 

The percent crop treated values that were used to refine the livestock commodities for the acute 

assessment were based on: sweet corn (57%) for beef, goat, horse, and sheep commodities; and the 

food handling establishment uses (5%) for hog and poultry meat and meat byproducts. 

The percent crop treated values that were used to refine the livestock commodities for the chronic 

assessment were based on: sweet corn (45%) for beef, goat, horse, sheep meat, fat, and meat 

byproducts; and the food handling establishment uses (5%) for hog and poultry meat and meat 

byproducts. 

IV. Drinking Water Data

The proposed new uses for abamectin are not expected to generate higher EDWCs than those 

previously generated (G. Orrick, D412861, 05/15/2014).

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: “Abamectin: 

Drinking Water Exposure Assessment for Proposed New Uses on Soybeans, Sweet Corn, 

Caneberries (Crop Group 13-07A), and Golf Course Tees, Greens, and Fairways” (D412861, G. 
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Orrick, 5/15/14) and incorporated directly into this dietary assessment. Water residues were 

incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, 

indirect, all sources.” The Tier II SWCC model was used to obtain the EDWCs from surface 

water. The Tier I Pesticide Root Zone Model - Ground Water (PRZM-GW) and Tier I Screening 

Concentration in Ground Water (SCI-GROW) models were used to assess residues in ground 

water. The EDWCs used in the acute and chronic assessments are the residues in surface water 

since the residues in ground water are lower. Considering all registered/proposed uses, the 

proposed use on soybeans in MS at 0.037 lb ai/A/year results in the highest acute drinking water 

exposure and the registered use on beans in MI at 0.056 lb ai/A/year results in the highest chronic 

drinking water exposure. For the acute EDWC, the 1-in-10 year annual maximum concentration 

was 0.76 ppb in surface water, as shown in Table 1 below. This value was not used in the 

assessment, however. Instead, HED used a residue distribution file for water provided by EFED. 

For the chronic assessment, the annual mean concentration of 0.30 ppb in surface water was used. 

Table 1. Screening-Level ROC EDWCs for Proposed Uses of Abamectin A

Source (Tier: Model) Use Site

(Max. Annual App. Rate)

Acute EDWC 

(μg/L)

Chronic 

EDWC 

(μg/L)

Surface water (Tier II: SWCC) Soybeans (0.037 lbs a.i./A)/ 

Beans (0.056 lbs a.i./A)

0.76 

(soybeans)

0.30

(beans)

Ground water (Tier I: PRZM-GW) Golf courses (0.27 lbs a.i./A) 0.074 N/A

Ground water (Tier I: SCI-GROW) Golf courses (0.27 lbs a.i./A) ≤0.0031 A Maximum values in bold.

The drinking water models and their descriptions are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

V. DEEM-FCID Program and Consumption Information

Abamectin acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 

3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average 
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daily consumption estimate for that food/food form to produce a residue intake estimate. The 

resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total average 

estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the 

cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

The Toxicology Science Advisory Council (ToxSAC) met on 9/11/14 to reassess toxicological 

endpoints for abamectin. The resulting toxicological endpoints are shown in Table 2. 

Acute Dietary Exposure Endpoint

For the acute dietary exposure, tremors and mydriasis seen in the subchronic (12- and 18-weeks) 

and chronic oral toxicity studies in dogs at the LOAEL of 0.5 mg/kg were selected as toxicity 

endpoints because tremors and mydriasis could be elicited by a single dose acting on the GABA 

receptors. The point of departure (NOAEL) was 0.25 mg/kg. There are 3 sets of data which 

support this selection: (1) kinetics data supports rapid absorption/excretion, (2) acute neurotoxicity 

was observed in rats, and (3) the effects produced by abamectin in beagle dogs did not progress 

with time. 

Kinetic data: Given the rapid absorption and elimination of abamectin, the Agency has concluded 

that the neurotoxic effects seen in the subchronic and chronic toxicity studies in dogs could be 

elicited by a single dose. As described previously, the kinetic data of abamectin show a pattern of 

rapid absorption and elimination. The proposed endpoint is, therefore, supported by the kinetics 

data. With oral dosing in rats, abamectin was absorbed rapidly, and maximum concentration in 

blood was achieved within 4-8 hours after administration. It was rapidly eliminated from the 

body, almost exclusively in the feces, and did not accumulate in the body after repeated exposure. 

The results of an abamectin kinetic study in wild type CF-1 mice (with fully functional P-gp) were 

consistent with kinetic results in rats: following a single oral administration, abamectin was rapidly 

absorbed, time to peak blood and plasma concentration was approximately 4 hours after dosing, 

and elimination was also fast, mainly by fecal route. In the CF-1 mouse, elimination expressed as 

percentage of the administered dose at various times after dosing were: 47-56% by 12 hours, 73-
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81% by 24 hours, and greater than 90% by 48 hours. 

Acute neurotoxicity study in rats: The conclusion based on the kinetics data was confirmed by 

results from the acute neurotoxicity study in rat (range finding and main studies) which showed 

that, with a single dose, the treated rats developed clinical signs of neurotoxicity such as reduced 

foot splay reflex, ataxia, tremors, and mydriasis (decreased pupillary light response). Most of 

these effects were consistent with those seen in the subchronic and chronic dog studies, except in 

rats the effects were observed at higher dose levels as rats were relatively less sensitive to the 

effects of abamectin relative to the beagle dogs. Therefore, tremors and mydriasis seen in the dog 

studies could be due a single dose. 

Effects seen in the subchronic and chronic dog studies: The effects seen in the subchronic 

(gavage) and chronic dog studies were similar despite repeated dosing, suggesting the response 

could be due to each individual exposure rather than to accumulation of abamectin in tissues. 

Purportedly, as the peak blood level of each administered dose passed, the response diminished or 

disappeared accordingly.

Safety factor for acute dietary exposure risk assessment: In previous risk assessments, an 

additional safety factor of 3x to account for the steepness of dose was employed. With the present 

analysis, the additional 3x safety factor is not necessary because a clear NOAEL was established in 

the dog studies used for toxicity endpoint selection. A total safety factor of 100x (10x for 

interspecies extrapolation and 10x for intraspecies variations) is appropriate and sufficient in 

establishing the acute reference dose (aRfD) (0.0025 mg/kg/day) for abamectin.

Chronic Dietary Exposure Endpoint

For chronic dietary exposure toxicity endpoints, tremors and mydriasis were selected based on the 

results of the subchronic and chronic oral toxicity studies in dogs. The point of departure is 0.25 

mg/kg/day (NOAEL). The adverse clinical signs were seen in both studies at a similar LOAEL 

(0.5 mg/kg/day). A total safety factor of 100x (10x for interspecies extrapolations and 10x for 

intraspecies variations) is appropriate and sufficient in establishing the chronic reference dose 

(cRfD; 0.0025 mg/kg/day) for abamectin.

Table 2. Summary of Toxicity Endpoints and Points of Departure for Abamectin

Exposure/ 

Scenarios

Point of 

Departure

Uncertainty/F

QPA Safety 

Factor

RFD, PAD, 

Level of 

Concern 

(LOC)

Study and Toxicological Effects

Acute Dietary 

(General 

Population, 

including 

Infants and 

Children)

NOAEL = 0.25 

mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 1 x

Acute RfD = 

0.0025 

mg/kg/day

aPAD =0.0025 

mg/kg/day

Subchronic & chronic oral toxicity 

studies in dogs 

Chronic LOAEL = 0.50 mg/kg/day 

based on body tremors, one death, liver 

pathology, decreased body weight. 

Mydriasis was seen during week one in 

one dog.

Subchronic LOAEL=0.5 mg/kg/day

based on mydriasis during week one, 

death at 1.0 mg/kg/day.
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Table 2. Summary of Toxicity Endpoints and Points of Departure for Abamectin

Exposure/ 

Scenarios

Point of 

Departure

Uncertainty/F

QPA Safety 

Factor

RFD, PAD, 

Level of 

Concern 

(LOC)

Study and Toxicological Effects

Chronic Dietary 

(All 

Populations)

NOAEL = 0.25 

mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 1x

Chronic RfD = 

0.0025

mg/kg/day

cPAD = 

0.0025 

mg/kg/day

Subchronic & Chronic and 90-day oral 

toxicity studies in Dogs 

Chronic LOAEL = 0.50 mg/kg/day 

based on body tremors, one death, liver 

pathology, decreased body weight. 

Mydriasis was seen during week one in 

one dog.

Subchronic LOAEL=0.5 mg/kg/day

based on mydriasis during week one, 

death at 1.0 mg/kg/day.

Cancer (oral, 

dermal, 

inhalation)

Classification: “Not likely to be Carcinogenic to Humans” based on the absence of significant 

tumor increases in two adequate rodent carcinogenicity studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity 

among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population 

adjusted dose (a = acute, c = chronic). RfD = reference dose. LOC = level of concern.

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure and risk of the U.S. 

population and various population subgroups. The results reported in Tables 3 and 4 are for the 

general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, females 13-49, adults 20-49, and adults 50-99 years old.

 

Results of Acute Dietary (Food and Drinking Water) Exposure and Risk Analysis

Abamectin dietary exposure at the 99.9th percentile for food and drinking water is 45% of the 

aPAD for the general U.S. population and 88% of the aPAD for children 1-2 years old, the most 

highly exposed population subgroup. The results of the acute dietary exposure analysis at the 95th, 

99th, and 99.9th percentiles of exposure are reported in Table 3.

Table 3. Results of Acute Dietary (Food and Drinking Water) Exposure Analysis 

Population Subgroup aPAD 

(mg/kg/day)

95th Percentile 99th Percentile 99.9th Percentile

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

General U.S. Population 0.0025 0.000228 9.1 0.000548 22 0.001135 45
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Table 3. Results of Acute Dietary (Food and Drinking Water) Exposure Analysis 

Population Subgroup aPAD 

(mg/kg/day)

95th Percentile 99th Percentile 99.9th Percentile

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

All Infants (< 1 year old) 0.000391 16 0.001077 43 0.001584 63

Children 1-2 years old* 0.000959 38 0.001402 56 0.002192 88

Children 3-5 years old 0.000554 22 0.000789 32 0.001553 62

Children 6-12 years old 0.000341 14 0.000497 20 0.000729 29

Youth 3-19 years old 0.000173 6.9 0.000286 11 0.000475 19

Adults 20-49 years old 0.000132 5.3 0.000219 8.8 0.000446 18

Adults 50-99 years old 0.000122 4.9 0.000199 8.0 0.000345 14

Females 13-49 years old 0.000134 5.4 0.000229 9.2 0.000427 17

*The subpopulation with the highest risk estimates at the 99.9th percentile is bolded.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

HED notes that the PODs selected for assessing acute and chronic dietary exposure are the same; 

because of the conservative, high-end nature of the inputs into an acute dietary exposure 

assessment, usually if the PODs are the same for both acute and chronic durations, only an acute 

dietary exposure assessment is conducted. However, a chronic dietary exposure assessment has 

been conducted for abamectin for the purposes of generating a dietary (food and drinking water) 

exposure estimate for the aggregate assessment and to incorporate residues/exposure from the food 

handling establishment (FHE) uses. 

Abamectin dietary exposure for food and drinking water is 2.2% of the cPAD for the general U.S. 

population and 11% of the cPAD for children 1-2 years old, the most highly exposed population 

subgroup. The results of the chronic dietary exposure analysis are reported in the summary table 

below.

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Abamectin

Population Subgroup

Acute Dietary

99.9th Percentile) Chronic Dietary

Dietary Exposure 

(mg/kg/day) % aPAD* Dietary Exposure(mg/kg/day) % cPAD*

General U.S. Population 0.001135 45 0.000056 2.2

All Infants (< 1 year old) 0.001584 63 0.000096 3.9

Children 1-2 years old* 0.002192 88 0.000268 11
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Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Abamectin

Population Subgroup

Acute Dietary

99.9th Percentile) Chronic Dietary

Dietary Exposure 

(mg/kg/day) % aPAD* Dietary Exposure(mg/kg/day) % cPAD*

Children 3-5 years old 0.001553 62 0.000160 6.4

Children 6-12 years old 0.000729 29 0.000090 3.6

Youth 13-19 years old 0.000475 19 0.000045 1.8

Adults 20-49 years old 0.000446 18 0.000038 1.5

Adults 50-99 years old 0.000345 14 0.000037 1.5

Females 13-49 years old 0.000427 17 0.000038 1.5

*

The subpopulation with the highest risk estimates is bolded.

VIII. Characterization of Inputs/Outputs

The acute and chronic assessments are both refined assessments. Anticipated residues based on 

field trials were used. Although field trial data provide more refined exposure estimates than 

tolerances, the results may still be considered somewhat conservative since field trials are 

conducted under maximum use conditions (maximum allowed application rate and number of 

applications, minimum preharvest interval, etc.). No monitoring data were used. Additionally, 

there are numerous non-detects in the crop field trials with abamectin indicating low residues in 

growing crops. Residues in the dietary exposure assessment were adjusted for % CT and empirical 

or default processing factors. A residue distribution file of water EDWCs was used for the acute 

assessment. A point estimate EDWC was used for the chronic assessment. The acute critical 

exposure contribution (CEC) analysis (Attachment 14) showed that milk is the major contributor

of dietary exposure for children 1-2 years old. The chronic critical commodity contribution 

analysis (CCCA) showed that milk and meat of beef are the major contributors for the general US 

population and milk is the major contributor of dietary exposure for children 1-2 years old.

IX. Conclusions

Refined acute and chronic dietary (food and drinking water) exposure assessments were conducted 

for all proposed and registered food uses of abamectin. Anticipated residues based on field trial 

data were used. Empirical and default processing factors and % CT were used. EDWCs from 

EFED were provided. A residue distribution file of water EDWCs was used for the acute 

assessment. A point estimate EDWC was used for the chronic assessment. 

The acute dietary exposure estimates for food and drinking water are not of concern (<100% 

aPAD) at the 99.9th percentile of exposure for the general U.S. population and all population 

subgroups.
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The chronic dietary exposure estimates for food and drinking water are not of concern (<100% 

cPAD) for the general U.S. population and all population subgroups.

Because these analyses were conducted using conservative assumptions such as field trial data and 

model-derived EDWCs, HED is confident that the assessment does not underestimate risk to the 

general U.S. population or any population subgroup.

X. List of Attachments

Attachment 1: Anticipated Residues Summary Table for Abamectin

Attachment 2: Acute Residue Distribution Files for Abamectin 

Attachment 3: Acute Food plus Water Residue Input File

Attachment 4: Acute Food plus Water Results File

Attachment 5: Acute Food only Results File

Attachment 6: Chronic Food plus Water Residue Input File

Attachment 7: Chronic Food plus Water Results File

Attachment 8: Acute Water Only Residue Input File

Attachment 9: Acute Water Only Results File

Attachment 10: Chronic Water Only Residue Input File

Attachment 11: Chronic Water Only Results File

Attachment 12: BEAD Percent Crop Treated Data

Attachment 13: Calculation of Livestock Anticipated Residues

Attachment 14: Acute Critical Exposure Contribution Analysis
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Attachment 1: Anticipated Residues Summary Table for Abamectin

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

Almond PB FT (D163057, MRID 

41822501) 6/0 0.001 70 80 RDF 1 0.001*0.70=0.00070

Almond, oil B See Almond. 70 80 0.001*0.80=

0.00080

0.001*0.70=

0.00070

Amaranth, leafy PB See Spinach. 100 100 RDF 45 0.044

Apple NB/PB FT 

(D201328;D201333) 31/31 0.073 juice 0.002 10 30 RDF 2 0.0039*0.10=0.00039

Apple, dried B See Apple. 8.0 dried 10 30 0.0039*0.30=

0.0012

0.0039*0.10=

0.00039

Apricot NB/PB See Peach. 6.0 dried 15 30 RDF 31 0.0057*0.15=0.

00086

Arrowroot, flour B See Potato. 100 100 0.0027 0.0027

Artichoke, Jerusalem NB See Potato. 100 100 RDF 36 0.0027

Arugula PB See Spinach. 100 100 RDF 45 0.044

Avocado NB FT (MRID 45083501) 10/10 0.001 35 60 RDF 4 0.0047*0.35=0.

0016

Balsam pear NB See Cucumber. 100 100 RDF 48 0.0022

Basil, fresh leaves B FT (MRID 45871901) 8/6 0.001 100 100 0.008 0.008

Basil, dried leaves B FT (MRID 45871901) 3/3 0.001 100 100 0.019 0.019

Bean, dry, seed B Tol (D380795, MRID 

48135003)

0.001 2.5 2.5 0.0041*0.025=

0.00010

0.0041*0.025=

0.00010

Bean, lima, 

succulent PB FT (D424008, MRID49455904) 100 100 0.004 (HAFT) 0.004

Bean, snap, 

succulent PB FT (D424008, MRID 49455908) 100 100 0.004 (HAFT) 0.004

Beef, fat6 PB Max Residue

(D414022) 0.001 45 57 RDF 24 0.038*0.45=0.0171
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Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

Beef, meat6 PB Max Residue 

(D414022) 1.92 dried 0.001 45 57 RDF 25 0.0084*0.45=0.0018

Beef, meat 

byproduct6 PB Max Residue(D414022) 0.001 45 57 RDF 26 0.076*0.45=0.0342

Blackberry PB FT (D412860; MRID 

49080101) 6/6 0.001 56 68 RDF 54 0.0293*0.56=0.016

Blueberry, lowbush PB See Strawberry. 0.003 100 100 RDF 62 0.017

Boysenberry PB See Raspberry. 56 68 RDF 55 0.0445*0.56=0.

025

Brazil nut PB See Pecan. 100 100 RDF 52 0.005

Butter nuts PB See Pecan. 100 100 RDF 52 0.005

Cantaloupe NB/PB

Cantaloupe FT 

(D203373, MRID 

43203801)

18/0 0.002 25 45 RDF 5 0.002*0.25=

0.00050

Cardoon NB See Celery. 100 100 RDF 7 0.014

Cashew PB See Pecan. 100 100 RDF 52 0.005

Cassava NB/PB See Potato. 100 100 RDF 36 0.0027

Celeriac NB FT (D268398; MRID

45079901) 8/4 0.002 100 100 0.017 0.0062

Celery NB/PB FT (D207554; MRID 

45096102) 84/84 0.002 45 70 RDF 8 0.014* 0.45 =0.0063

Celtuce NB See Celery. 100 100 RDF 7 0.014

Chayote, fruit NB See Squash, summer. 100 100 RDF 49 0.002

Cherry PB FT (MRID

45096707/45096708) 37/37 1.5 juice 0.001 5 20 RDF 29 0.016*0.05=0.00080

Chestnut PB See Almond. 100 100 RDF 51 0.001

Chinese waxgourd NB See Cucumber. 100 100 RDF 48 0.0022

Chive, fresh leaves B Tol (D380795, MRID

48135002) 0.001 100 100 0.0041 0.0041

Chive, dried leaves B Tol (D380795, MRID 

48135002) 2.9 dried 0.001 100 100 0.0041 0.0041
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Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

Chrysanthemum, 

Garland

PB See Spinach. 100 100 RDF 45 0.044

Citrus citron and 

Citrus hybrids

NB See Orange. 100 100 RDF 53 0.0041

Citrus, oil B See Orange. 9.7 oil 100 100 0.0041 0.0041

Coconut PB/B/NB See Almond. 2.1 dried 100 100 0.01 0.001

Corn, sweet, kernel 

plus cob with husk 

removed

NB/PB

FT (D414022; MRID 

49071008) 12/0 0.003 45 57 RDF 58 0.006*0.45=

0.0027

Cottonseed oil B FT (D401832 ) 22/3 0.003 20 30 0.0070*0.30=

0.0021

0.0070*0.20=

0.0014

Crabapple NB See Apple. 0.002 100 100 RDF 63 0.0039

Cranberry PB See Strawberry. 1.1 juice 0.003 100 100 RDF 62 0.017

Cress, garden PB See Spinach. 100 100 RDF 45 0.044

Cress, upland PB See Spinach. 100 100 RDF 45 0.044

Cucumber NB/PB FT (D203373, MRID 

43203801) 8/1 0.002 5 10 RDF 46 0.0022*0.05=0.00011

Dandelion, leaves PB See Spinach. 100 100 RDF 45 0.044

Dasheen, corm NB See Potato. 100 100 RDF 36 0.0027

Dillweed B See Basil, fresh leaves 100 100 0.008 0.008

Eggplant NB/PB See Bell pepper. 100 100 RDF 9 0.0034

Endive PB See spinach. 100 100 RDF 45 0.044

Fennel, Florence NB See Celery. 100 100 RDF 7 0.014

Garlic NB/PB Tol (D380795, MRID 

48135001) 0.001 100 100 0.0046 0.0040

Ginger NB/PB See Potato. 100 100 RDF 36 0.0027
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Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

Ginger, dried B See Potato. 100 100 0.0027 0.0027

Goat, fat6 PB Max Residue

(D414022) 0.001 45 57 RDF 39 0.0088*0.45=0.0.0036

Goat, meat6 PB Max Residue

(D414022) 0.001 45 57 RDF 65 0.0027*0.45=0.001215

Goat, kidney6 PB Max Residue 

(D414022) 0.001 45 57 RDF38 0.0027*0.45=0.001215

Goat, meat 

byproducts (incl. 

liver)6

PB Max Residue

(D414022) 0.001 45 57 RDF 38 0.011*0.45=

0.00495

Goji berry PB See Tomato FT. 0.002 100 100 RDF 47 0.0027

Gooseberry PB See Grape. 0.001 100 100 RDF 61 0.0023

Grape PB FT (MRID 44346001) 26/26 0.47 juice 0.001 15 35 RDF 12 0.0023*0.15=

0.00034

Grape, raisin PB See Grape. 0.75 0.001 15 35 RDF 13 0.0023*0.15= 

0.00034

Grapefruit NB/PB FT (D207554) 6/6 0.85 juice 0.001 70 90 RDF 11 0.00125*0.70=

0.00088

Guava4 NB/PB FT (D424008, MRID 

49455903) 100 100 0.0050 (HAFT) 0.0043

Hazelnuts PB See Pecan FT.

(MRID 45096709) 22/22 2.5 2.5 RDF 28 0.005*0.025=0.00012

Hazelnut, oil B See Hazelnuts. 2.5 2.5 0.005*0.025=

0.00012

0.005*0.025=

0.00012

Herbs, other B See Basil, fresh leaves 100 100 0.008 0.008

Hickory nut PB See Pecan. 100 100 RDF 52 0.005
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Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

Honeydew NB/PB Cantaloupe FT 

(MRID 43203801) 18/0 0.002 20 35 RDF 37 0.002 x 0.20 = 0.00040

Horse, Sheep, meat6 PB Max Residue 

(D414022) 0.001 45 57 RDF 65 0.0024*0.45=0.00108

Hop B FT (MRID 43733101) 10/10 0.001 100 100 0.051 0.051

Kumquat PB See Orange. 100 100 RDF 53 0.0041

Lemon NB/PB FT (D207554) 4/4 0.25 juice

2.5 peel 0.001 40 55 RDF 33 0.00125*0.40=0.00050

Lemongrass B See Basil, fresh leaves 100 100 0.008 0.008

Lettuce, head NB FT (D207554, MRID 

45096702) 22/22 0.002 20 45 RDF 14 0.0086*0.20=0.00172

Lettuce, leaf PB FT (D254546, MRID 

44708506) 12/12 0.002 20 45 RDF 42 0.023*0.20 =0.0046

Lime PB See Lemon. 0.25 juice 100 100 RDF 35 0.00125

Loganberry PB See Raspberry FT. 56 68 RDF 55 0.0445

Loquat NB See Pear. 0.005 100 100 RDF 64 0.0074

Lychee4 NB FT (D424008, MRID 

49455905) 100 100 0.0027 (HAFT) 0.0024 (Mean)

Lychee, dried B FT (D424008, MRID 

49455905) 1.85 dried 100 100 0.0024 (Mean) 0.0024

Macadamia nut PB See Pecan. 100 100 RDF 52 0.005

Marjoram B See Basil, fresh leaves 100 100 0.008 0.008

Milk6 PB Max Residue 

(D414022) 0.001 45 57 RDF 16 0.011*0.45=0.0055

Nectarine NB See Peach. 20 20 RDF 50 0.0057*0.20=0.

0011

Okra NB/PB See Pepper, non-bell. 0.002 100 100 0.006 0.004

Onion, bulb NB/PB FT (D380795, MRID

48135001) 0.001 2.5 10 RDF 59 0.0040*0.025=0.00010
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Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

Onion, bulb, dried B See Onion, bulb. 9.0 dried 2.5 10 0.0040*0.10=

0.00040

0.0040*0.025=

0.00010

Onion, green, 

subgroup 3-07B NB/PB FT (D424008, MRID 49455902) 100 100 0.0046 (HAFT) 0.004

Orange NB/PB FT (D207554) 16/16 0.25 juice

2.5 peel 0.005 40 70 RDF 15 0.0041*0.40=0.0016

Papaya4 NB/PB FT (D424008, MRID 

49455906) 1.5 juice 100 100 RDF 66 0.0863

Papaya, dried B FT (D424008, MRID 

49455906) 1.8 dried 100 100 0.0863 (Mean) 0.0863

Parsley, leaves PB See Spinach 100 100 RDF 45 0.044

Parsley, dried leaves B Basil FT (MRID 

45871901) 3/3 0.001 100 100 0.019 0.019

Peach NB/PB FT (MRID 

45096707/45096708) 27/27 0.001 10 25 RDF 30 0.0057*0.10=0.00057

Peach, dried B See Peach. 7.0 dried 0.001 10 25 0.0057*0.25=

0.0014

0.0057*0.10=

0.00057

Pear NB/PB FT (D207554) 8/8 0.005 70 85 RDF 17 0.0074*0.70=0.

0052

Pear, dried B See Pear. 6.25 dried 0.005 70 85 0.0074*0.85=

0.0063

0.0074*0.70=

0.0052

Pecan PB FT (MRID 45096709)

D316756 22/22 0.005 1 2.5 RDF 28 0.005*0.01=0.000050

Pepper, bell NB/PB FT (D206550, MRID 

43334601) 6/2 0.002 15 30 RDF 19 0.0034*0.15=

0.00051

Pepper, bell, dried B See Pepper, bell. 0.002 15 30 0.0034*0.30=

0.0010

0.0034*0.15=

0.00051

Pepper, non-bell NB/PB

FT (chili pepper)

(D238327, MRID 

44300002)

8/4 0.002 15 30 RDF 41 0.0040 *0.15=

0.00060
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PC Code: 122804

Page 22 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

Pepper, non-bell,

Dried B See Pepper, non-bell. 0.002 15 30 0.0040*0.30=0.0012

0.0040 *0.15=

0.00060

Peppermint B FT (MRID 45096706) 14/4 0.001 100 100 0.047 0.047

Pineapple NB/PB FT (D424008, MRID 

49455907) 1.7 juice 100 100 0.004 (HAFT) 0.004 (Mean)

Pineapple, dried B FT (D424008, MRID 

49455907) 5 dried 100 100 0.004 (Mean) 0.004 (Mean)

Pine nut PB See Almond. 100 100 RDF 51 0.001

Pistachio PB See Almond. 2.5 2.5 RDF 57 0.001 x 0.025 

=0.000025

Plum (Prune) NB/PB FT (MRID 44708503) 30/9 5.0 dried

1.4 juice 0.001 10 35 RDF 18 0.0020*0.10=0.0002

Plum (Non-prune) NB/PB FT (MRID 44708503) 30/9 5.0 dried

1.4 juice 0.001 100 100 RDF 56 0.0020*1.00=0.0020

Pork fat6 PB Tol (D414022) 0.001 5 5 RDF 27 0.01*0.05 =

0.0005

Pork meat/mbypd6 PB Tol (D414022) 0.001 5 5 RDF 40 0.02*0.05 =

0.001

Potato NB/PB FT (MRID 45096705) 15/15 0.002 5 20 RDF 20 0.0027*0.05=0.

00014

Potato, chips

Potato, dry

Potato, flour

B See Potato. 6.5 dry

6.5 flour 0.002 5 20 0.0027*0.20=

0.00054

0.0027*0.05 =

0.00014

Poultry

meat/mbypd5, 6 PB Tol (D414022) 0.001 5 5 RDF 40 0.02*0.05 =0.001

Pummelo NB See grapefruit. 100 100 RDF 10 0.00125

Pumpkin NB/PB Summer squash FT 

(MRID 43203801) 8/0 0.001 5 10 RDF 3 0.002*0.05=0.0001

Quince NB See Pear. 0.005 100 100 RDF 64 0.0074

Radicchio NB See Lettuce, head. 0.001 100 100 RDF 43 0.0086

Raspberry PB FT (D412860; MRID 8/8 0.001 56 68 RDF 55 0.0445*0.56=
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 23 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

49080101) 0.025

Rhubarb NB/PB See Celery. 100 100 RDF 7 0.014

Savory B See Basil, fresh leaves 100 100 0.008 0.008

Shallot, bulb NB Tol (D380795, MRID 

48135001) 0.001 100 100 0.0046 0.0040

Sheep, fat6 PB Max Residue 

(D414022) 0.001 45 57 RDF 39 0.0168*0.45= 0.00756

Sheep, kidney6 PB Max Residue 

(D414022) 0.001 45 57 RDF 38 0.0060*0.45= 0.0027

Sheep, liver6 PB Max Residue 

(D414022) 0.001 45 57 RDF 38 0.024*0.45= 0.0108

Sheep, meat 

byproducts6 PB Max Residue (D414022) 0.001 45 57 RDF 38 0.024*0.45= 0.0108

Soybean B FT (D414022; MRID 

49071010) 20/0 0.001 8 11 0.006*0.11=0.00066

0.006*0.08=

0.00048

Spearmint B FT (MRID 45096706) 14/4 0.001 100 100 0.047 0.047

Spinach PB FT (D254546, MRID 

44708506) 12/12 0.002 25 45 RDF 44 0.044*0.25=0.011

Squash, summer NB/PB FT (MRID 43203801) 8/0 0.001 5 15 RDF 6 0.002*0.05=

0.00010

Squash, winter NB/PB See Squash, summer. 5 15 RDF 6 0.002*0.05=

0.00010

Strawberry PB FT (D401832) 12/12 0.003 30 45 RDF 21 0.017*0.30=

0.0051

Sweet potato NB/PB See Potato. 100 100 RDF 36 0.0027

Swiss chard NB See Celery. 100 100 RDF 7 0.014

Tangerine NB/PB FT Orange and 

Tangelo (D207554) 20/6 0.25 juice 35 55 RDF 34 0.0035*0.35=0.0012

Tanier, corm NB See Potato. 100 100 RDF 36 0.0027
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 24 of 60

Table A.1. Anticipated Residues Summary Table for Abamectin

Commodity1

DEEM Food 

Form/

(Classification2)

Data Source

No. of 

Samples/ 

No. of 

Detectable 

Residues

Processing 

Factors

1⁄2 LOD 

(ppm)

% CT Anticipated Residue 

Estimates/Tolerance

Avg. Max.

Acute

(Tol., AR, 

RDF)

Chronic3

(Tol., AR)

Tomato, 

Greenhouse-grown

NB/PB GH (D424008, MRID 

49455901) 8/8

14.3 dried

0.21 juice

1.2 paste

0.40 puree

0.002 10 25 RDF 22

0.017(Mean)*0.

10=

0.0017

Tomato tree NB See Tomato FT. 0.002 100 100 RDF 47 0.0027

Tomatillo NB/PB See Tomato FT. 0.002 100 100 RDF 47 0.0027

Turmeric NB/PB See Potato. 100 100 RDF 36 0.0027

Walnut PB FT (D163057, MRID 

41822501) 6/0 0.001 25 55 RDF 23 0.001*0.25 = 0.00025

Watermelon NB/PB

FT(Watermelon 

+Cantaloupe) 

(D203373, MRID 

43203801)

22/0 0.001 5 15 RDF 32

0.002*0.05=

0.00010

Yam, bean NB See Potato. 100 100 RDF 36 0.0027

Yam, true NB See Potato. 100 100 RDF 36 0.0027 1 Percent crop treated data were provided for tangelos and pluots (plum/apricot hybrids), but tangelos and pluots were not included in this table because they 

are not included in the DEEM. 2 M. Stasikowski, 8/20/99, Classification of Food Forms with Respect to Level of Blending. HED Standard Operating Procedure 99.6; and F. Fort, Draft 

Revised Blending Classification.

3 In this chronic dietary assessment, no residue used was less than the food handling establishment (FHE) value (1/2 LOD = 0.002 ppm) x 5% CT for food in food 

handling establishments (0.0002 x 0.05). 4 The commodity definitions for guava, lychee, and papaya are stated in EPA’s “Reviewer’s Guide and Summary of HED ChemSAC Approvals for 

Amending Crop Groups/Subgroups [40 CFR §180.41] and Commodity Definitions [40 CFR §180.1(h)]” (Bernard Schneider, June 14, 2006). According to that 

document, guava includes guava, feijoa, jaboticaba, wax jambu, starfruit, passionfruit, and acerola; lychee includes lychee, longan, Spanish lime, rambutan, 

and pulasan; and papaya includes papaya, black sapote, canistel, mamey sapote, mango, sapodilla, and star apple. The petitioner is not requesting use on mango. 5 No tolerance has been established for poultry fat.

6 The %CT values that were used to refine livestock commodities were sweet corn forage for ruminants and food handling establishment uses for poultry and swine.
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 25 of 60

Attachment 2: Acute Residue Distribution Files for Abamectin and Chronic Point Estimates

Table A.2. Acute Residue Distribution Files for Abamectin

RDF#1 Almond

'Almond2008_FT

80%CT

TOTALZ=2

TOTALNZ=6

0.001 0.001 0.001 0.001 

0.001 0.001

RDF#2 Apple

'Apple2008_FT

30%CT

TOTALZ=72

TOTALNZ=31

0.003 0.003 0.002 0.0079 

0.0051 0.0041 0.0037 0.003

0.002 0.0039 0.003 0.0034

0.003 0.012 0.0091 0.002 

0.002 0.0079 0.0055 0.0036 

0.003 0.003 0.002 0.002 

0.002 0.003 0.0047 0.003 

0.0043 0.002 0.0038

RDF#3 Pumpkin

‘Summer Squash FT 

10%CT

TOTALZ=72

TOTALNZ=8

0.002 0.002 0.002 0.002 

0.002 0.002 0.002 0.002

RDF#4 Avocado

'Avocado FT 

60%CT

TOTALZ=7

TOTALNZ=10

0.002 0.006 0.004 0.004 

0.002 0.002 0.004 0.007 

0.010 0.006

RDF#5 Cantaloupe

'Cantaloupe FT 45%CT

TOTALZ=22

TOTALNZ=18

18, 0.002

RDF#6 Summer squash

'Summer squash2008_FT

15%CT

TOTALZ=45

TOTALNZ=8

8, 0.002

RDF#7 Celery1

100%CT'Celery FT

100%CT

TOTALZ=0

TOTALNZ=84

0.0121 0.0231 0.0082 

0.0166 0.006 0.006 0.006 

0.006 0.006 0.0074 0.0074 

0.0089 0.006 0.006 0.006 

0.006 0.006 0.0073 0.00125 

0.006 0.0098 0.0105 0.0157 

0.0208 0.0116 0.0076 

0.0088 0.092 0.006 0.0082 

0.0066 0.0067 0.0406 

0.0097 0.0175 0.0097 

0.0095 0.0088 0.0089 0.006 

0.006 0.006 0.006 0.006 

0.006 0.006 0.006 0.006 

0.006 0.007 0.00111 0.0341 

0.0083 0.021 0.0082 0.0093 

0.0092 0.006 0.0192 0.0121 

0.0198 0.0281 0.0281 

0.0292 0.0205 0.0231 

0.0105 0.0098 0.0132 

0.0135 0.0066 0.0074 0.012 

0.0128 0.0085 0.0083 

0.0066 0.0234 0.0091 

0.0067 0.0101 0.0106 0.148 

0.06

RDF#8 Celery

'Celery FT

70%CT

TOTALZ=36

TOTALNZ=84

0.0121 0.0231 0.0082 

0.0166 0.006 0.006 0.006 

0.006 0.006 0.0074 0.0074 

0.0089 0.006 0.006 0.006 

0.006 0.006 0.0073 0.00125 

0.006 0.0098 0.0105 0.0157 

0.0208 0.0116 0.0076 

0.0088 0.092 0.006 0.0082 

0.0066 0.0067 0.0406 

0.0097 0.0175 0.0097 

0.0095 0.0088 0.0089 0.006 

0.006 0.006 0.006 0.006 

0.006 0.006 0.006 0.006 

0.006 0.007 0.00111 0.0341 

0.0083 0.021 0.0082 0.0093 

0.0092 0.006 0.0192 0.0121 

0.0198 0.0281 0.0281 

0.0292 0.0205 0.0231 

0.0105 0.0098 0.0132 

0.0135 0.0066 0.0074 0.012 

0.0128 0.0085 0.0083 

0.0066 0.0234 0.0091 

0.0067 0.0101 0.0106 0.148 

0.06
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 26 of 60

Table A.2. Acute Residue Distribution Files for Abamectin

RDF#9 Eggplant

'Pepper, bell FT 

100%CT 

TOTALZ=0

TOTALNZ=6

0.00125

0.00125

0.00125

0.00125

0.00938

0.00600

RDF#10 Grapefruit 2

100%CT

'Grapefruit FT 

100%CT

TOTALZ=0

TOTALNZ=6

0.00125

0.00125

0.00125

0.00125

0.00125

0.00125

RDF#11 Grapefruit

'Grapefruit FT 

90%CT

TOTALZ=1

TOTALNZ=6

0.00125

0.00125

0.00125

0.00125

0.00125

0.00125

RDF#12 Grape

'Grape FT 

35%CT 

TOTALZ=48

TOTALNZ=26

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.0060 0.0077 

0.0037 0.0040 0.0053 

0.0063 0.0034

RDF#13 Grape-raisin

'Grape-raisin FT 35%CT

TOTALZ=48

TOTALNZ=26

19, 0.00125 0.0060 0.0077 

0.0037 0.0040 0.0053 

0.0063 0.0034 

RDF#14 Lettuce, head

'Lettuce, head FT

45%CT 

TOTALZ=27

TOTALNZ=22

0.0346 0.0335 0.0063 

0.0076 0.00125 0.00125 

0.00125 0.00125 0.0302 

0.0259 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.0066 0.0265 

0.00125 0.00125 0.00125 

0.00125

RDF#15 Orange

'Orange FT

70%CT 

TOTALZ=7

TOTALNZ=16

0.00125 0.00125 0.00125 

0.00125 0.0091 0.0088 

0.006 0.006 0.0111 0.0122 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125

RDF#16 Milk

'Milk FT data 

'57%CT from sweet corn 

cannery waste'

TOTALZ=43

TOTALFREQ=1

57, 0.011

RDF#17 Pear

'Pear FT

85%CT

TOTALZ=1

TOTALNZ=8

0.0044 0.0039 0.0053 

0.0064 0.0061 0.0109 

0.0126 0.0098

RDF#18 Plum(prune)

'Plum(prune)FT 

35%CT

TOTALZ=56

TOTALNZ=30

0.001 0.001 0.001 0.001 

0.001 0.001 0.001 0.001 

0.001 0.001 0.001 0.001 

0.001 0.001 0.001 0.001 

0.001 0.001 0.001 0.001 

0.001 0.001 0.0065 0.0045

0.0035 0.0035 0.0035 

0.0055 0.0055 0.0055

RDF#19 Pepper, bell

'Pepper,bell FT 

30%CT 

TOTALZ=14

TOTALNZ=6

0.00125

0.00125

0.00125

0.00125

0.00938

0.00600

RDF#20 Potato

'Potato FT

20%CT

TOTALZ=60

TOTALNZ=15

0.003 0.003 0.003 0.003 

0.003 0.003 0.003 0.003 

0.003 0.003 0.003 0.002 

0.002 0.002 0.002

RDF#21 Strawberry

'Strawberry FT

45%CT

TOTALZ=15

TOTALNZ=12

0.013 0.011 0.016 0.012 

0.013 0.019 0.025 0.022 

0.022 0.028 0.008 0.013

RDF#22 Tomato_GH3

‘GH Tomato

25% CT

TOTALZ=24

TOTALNZ=8

0.02476 0.04120 0.01864 

0.01549 0.01216 0.01021 

0.00684 0.00587

RDF#23 Walnut

'Walnut FT 

'55%CT

TOTALZ=5

TOTALNZ=6

0.001 0.001 0.001 0.001 

0.001 0.001

RDF#24 Beet-fat

'Beef fat 

'57%CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57, 0.038
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 27 of 60

Table A.2. Acute Residue Distribution Files for Abamectin

RDF#25Beef meat 

57%CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57, 0.0084

RDF#26 Beef-mbypd

'Beef mbypd 

57%CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57, 0.076

RDF#27 Hog fat4

‘Hog fat

5%CT from FHE

TOTALZ=95

TOTALFREQ=1

5, 0.01

RDF#28 Pecan

'Pecan FT

'2.5%CT

TOTALZ=858

TOTALNZ=22

22, 0.01

RDF#29 Cherry

'Cherry FT 

20%CT

TOTALZ=148

TOTALNZ=37

0.009 0.011 0.009 0.013 

0.005 0.005 0.006 0.008 

0.006 0.006 0.005 0.02 

0.017 0.016 0.015 0.009 

0.009 0.022 0.016 0.016 

0.065 0.04 0.028 0.032 0.015 

0.031 0.025 0.026 0.012 

0.012 0.009 0.009 0.007 

0.017 0.006 0.009 0.009

RDF#30 Peach

'Peach FT

25%CT

TOTALZ=81

TOTALNZ=27

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.005 

0.007 0.007 0.007 0.005 

0.009 0.011 0.026

RDF#31 Apricot

'Peach FT

30%CT

TOTALZ=63

TOTALNZ=27

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.005 

0.007 0.007 0.007 0.005 

0.009 0.011 0.026

RDF#32 Watermelon

‘Watermelon + Cantaloupe 

FT 15%CT

TOTALZ=125

TOTALNZ=22

22, 0.002

RDF#33 Lemon

'Lemon FT 

55%CT 

TOTALZ=3

TOTALNZ=4

0.00125

0.00125

0.00125

0.00125

RDF#34 Tangerine

'Orange + Tangelo FT 

55%CT

TOTALZ=16

TOTALNZ=20

0.00125 0.00125 0.00125 

0.00125 0.0091 0.0088 

0.006 0.006 0.0111 0.0122 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125

RDF#35 Lemon 100%CT

'Lemon FT 

100%CT 

TOTALZ=0

TOTALNZ=4

0.00125

0.00125

0.00125

0.00125

RDF#36 Subgroup 1C5

'Potato FT

100%CT

TOTALZ=0

TOTALNZ=15

0.003 0.003 0.003 0.003 

0.003 0.003 0.003 0.003 

0.003 0.003 0.003 0.002 

0.002 0.002 0.002

RDF#37 Honeydew

‘Cantaloupe FT 

35%CT 

TOTALZ=33

TOTALNZ=18

18, 0.002

RDF#38 Goat, Horse, Sheep 

mbypd

‘Goat, Horse, Sheep mbypd

57%CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57, 0.024

RDF#39 Goat, Horse, Sheep 

Fat

57%CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57, 0.0168

RDF#40 Hog, Poultry meat 

and mbypd4,6

‘Hog, Poultry m, mbypd; 

tolerance

5%CT from FHE

TOTALZ=95

TOTALFREQ=1

5, 0.02

RDF#41 Pepper, chili 

'Chili Pepper FT 

30%CT 

TOTALZ=19

TOTALNZ=8

0.002 0.002 0.002 0.002 

0.006 0.006 0.006 0.006

RDF#42 Lettuce,leaf

'Lettuce.leaf FT 

45%CT 

TOTALZ=15

TOTALNZ=12

0.016 0.017 0.007 0.010 

0.061 0.046 0.013 0.023 

0.020 0.017 0.020 0.027

RDF#43 Radicchio 

'Lettuce,head FT 

100%CT 

TOTALZ=0

TOTALNZ=22

0.0346 0.0335 0.0063 

0.0076 0.00125 0.00125 

0.00125 0.00125 0.0302 

0.0259 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.0066 0.0265 

0.00125 0.00125 0.00125 

0.00125

RDF#44 Spinach

Spinach FT 

45%CT 

TOTALZ=15

TOTALNZ=12

0.0285 0.0305 0.099 0.086 

0.022 0.027 0.052 0.043 

0.023 0.019 0.046 0.048 
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 28 of 60

Table A.2. Acute Residue Distribution Files for Abamectin

RDF#45 Spinach7

'Spinach FT 

100%CT 

TOTALZ=0

TOTALNZ=12

0.0285 0.0305 0.099 0.086 

0.022 0.027 0.052 0.043 

0.023 0.019 0.046 0.048 

RDF#46 Cucumber

'Cucumber FT 

10%CT

TOTALZ=72

TOTALNZ=8

0.036 0.002 0.002 0.002 

0.002 0.002 0.002 0.002

RDF#47 Tomato 100%CT8

'Tomato FT

100%CT 

TOTALZ=0

TOTALNZ=45

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125 

0.0064 0.006 0.006 0.006 

0.006 0.0262 0.006 0.0077 

0.006

RDF#48 Cucumber 100% 

CT9

'Cucumber FT 

100%CT

TOTALZ=0

TOTALNZ=8

0.036 0.002 0.002 0.002 

0.002 0.002 0.002 0.002

RDF#49 Squash 100% CT10

'Summer squash FT 

100%CT

TOTALZ=0

TOTALNZ=8

0.002 0.002 0.002 0.002 

0.002 0.002 0.002 0.002 

RDF#50 Nectarine

'Peach FT

20%CT

TOTALZ=108

TOTALNZ=27

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.004 

0.004 0.004 0.004 0.005 

0.007 0.007 0.007 0.005 

0.009 0.011 0.026

RDF#51 Almond 100%CT11

'Almond FT

100%CT

TOTALZ=0

TOTALNZ=6

0.001 0.001 0.001 0.001 

0.001 0.001

RDF#52 Pecan 100%CT12

'Pecan FT

100%CT

TOTALZ=0

TOTALNZ=22

0.01 0.01 0.01 0.01 0.01 

0.01 0.01 0.01 0.01 0.01 

0.01 0.01 0.01 0.01 0.01 

0.01 0.01 0.01 0.01 0.01 

0.01 0.01

RDF#53 Orange 100%CT13

'Orange FT

100%CT 

TOTALZ=0

TOTALNZ=16

0.00125 0.00125 0.00125 

0.00125 0.0091 0.0088 

0.006 0.006 0.0111 0.0122 

0.00125 0.00125 0.00125 

0.00125 0.00125 0.00125

RDF#54 Blackberry

Blackberry FT

68%CT

TOTALZ=4

TOTALNZ=8

0.0632

0.0438

0.0236

0.0171

0.0178

0.0164

0.0265

0.0258

RDF#55 Raspberry14

'Raspberry FT

68%CT

TOTALZ=3

TOTALNZ=6

0.0076

0.0091

0.0072

0.0062

0.1215

0.1152

RDF#56 Plum (non-prune)

'Plum(non-prune)FT 

100%CT

TOTALZ=0

TOTALNZ=30

0.001 0.001 0.001 0.001 

0.001 0.001 0.001 0.001 

0.001 0.001 0.001 0.001 

0.001 0.001 0.001 0.001 

0.001 0.001 0.001 0.001 

0.001 0.001 0.0065 0.0045

0.0035 0.0035 0.0035 

0.0055 0.0055 0.0055

RDF#57 Pistachio

'Almond2008_FT

2.5%CT

TOTALZ=234

TOTALNZ=6

0.001 0.001 0.001 0.001 

0.001 0.001

RDF#58 Sweet Corn

‘Sweet Corn_FT

57%CT

TOTALZ=9

TOTALNZ=12

0.006 0.006 0.006 0.006 

0.006 0.006 0.006 0.006 

0.006 0.006 0.006 0.006

RDF#59 Onion, Bulb

‘Onion Bulb_FT

10% CT

TOTALZ=72

TOTALNZ=8

0.0043 0.0040 0.0040 

0.0040 0.0040 0.0040 

0.0040 0.0040

RDF#60 Drinking Water

Soybean Drinking Water
Abamectin Dietary Exposure Assessment D424009, D421348

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Page 29 of 60

Table A.2. Acute Residue Distribution Files for Abamectin

RDF#61 Gooseberry

'Grape FT 

100%CT 

TOTALZ=0

TOTALNZ=26

.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.00125 0.00125

0.00125 0.0060 0.0077 

0.0037 0.0040 0.0053 

0.0063 0.0034

RDF#62 Strawberry

100%CT15

'Strawberry FT

100%CT

TOTALZ=0

TOTALNZ=12

0.013 0.011 0.016 0.012 

0.013 0.019 0.025 0.022 

0.022 0.028 0.008 0.013

RDF#63 Apple100%CT16

'Apple2008_FT

100%CT

TOTALZ=0

TOTALNZ=31

0.003 0.003 0.002 0.0079 

0.0051 0.0041 0.0037 0.003

0.002 0.0039 0.003 0.0034

0.003 0.012 0.0091 0.002 

0.002 0.0079 0.0055 0.0036 

0.003 0.003 0.002 0.002 

0.002 0.003 0.0047 0.003 

0.0043 0.002 0.0038

RDF#64 Pear100%CT17

'Pear FT

100%CT

TOTALZ=0

TOTALNZ=8

0.0044 0.0039 0.0053 

0.0064 0.0061 0.0109 

0.0126 0.0098

RDF#65: Goat, Horse, 

Sheep Meat

‘Goat, Horse, Sheep Meat

57%CT from Sweet Corn

TOTALZ= 43

TOTALFREQ=1

57, 0.0024

RDF #66 Papaya

100%CT

TOTALZ=0

TOTALNZ=3

0.0051

0.131

0.123 1 RDF used for celtuce, cardoon, fennel, rhubarb, and Swiss chard. 2 RDF used for pummelo. 3

RDF#22 contains only greenhouse-grown tomato data; RDF #22 was used for all tomatoes since greenhouse data 

were higher than field-grown tomato data. 4 The residues in hog and poultry commodities from consuming treated feed are considerably less than the current 

tolerances from the food handling establishment use. Therefore, the percent food treated of 5% was used in the 

residue data files for poultry and hog commodities.

5 RDF used for Tanier, corm; turmeric; ginger; artichoke; yam, bean; yam, true; sweet potato; cassava; dasheem, corm. 6

. RDF#40 was used for hog meat/mbypd and poultry meat/mbypd. 7 RDF used for parsley, garden cress, upland cress, chrysanthemum garland, amaranth, parsley leaves, dandelion 

leaves, endive. 8 RDF used for tree tomato, tomatillo, goji berry. 9 RDF used for chinese waxgourd, balsam pear. 10 RDF used for chayote. 11 RDF used for pine nut, chestnut. 12 RDF used for brazil nut, butter nut, cashew, hickory nut, macadamia. 13 RDF used for kumquat, citron, citrus hybrids. 14 RDF used for raspberry, boysenberry, loganberry. 15 RDF used for cranberry. 16 RDF used for crabapple. 17 RDF used for loquat.
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 30 of 60

Attachment 3: Acute Food plus Water Residue Input File

Filename: C:\Users\KRURY\Documents\My Work Files\Abamectin\Dietary Files\Abamectin acute 

Food and Water PRIA 3 29 16.R08

Chemical: Avermectin

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 03-29-2016/12:31:57 Program ver. 3.16, 03-08-d

Comment: Food and Water at 0.76 ppb; Updated 3/23/16

-----------------------------------------------------------------------------------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

 # Code 

----- ---- ------------ -------- -------- -------

 1 6 Almond2008_FT.RDF

 2 6 Apple2008_FT.RDF

 3 6 Pumpkin2008_FT.RDF

 4 6 Avocado2008.RDF

 5 6 Cantaloupe2008_FT.RDF

 6 6 Summer squash2008_FT.RDF

 7 6 Celery 100%CT_FT.RDF

 8 6 Celery2008_FT.RDF

 9 6 Eggplant2008.RDF

 10 6 Grapefruit100%CT_FT.RDF

 11 6 Grapefruit2008_FT.RDF

 12 6 Grapes2008.RDF

 13 6 Grape-raisin2008.RDF

 14 6 Lettuce,head 2008_FT.RDF

 15 6 Orange2008_FT.RDF

 16 6 Milk2016_FT_57.RDF

 17 6 Pear2008_FT.RDF

 18 6 Plum (prune)2008.RDF

 19 6 Pepper,bell2008_FT.RDF

 20 6 Potato2008_FT.RDF

 21 6 Strawberry2012.RDF

 22 6 Tomato_GH.RDF

 23 6 Walnut2008.RDF

 24 6 Beef-fat57CT.RDF

 25 6 Beef, sheep, goat meat_FT.RDF

 26 6 Beef-mbyp2008_FT.RDF

 27 6 Hog-fat_FHE.RDF

 28 6 Pecan2008.RDF

 29 6 Cherry2008.RDF

 30 6 Peach2008.RDF

 31 6 Apricot2008.RDF

 32 6 Watermelon_FT.RDF

 33 6 Lemon2008_FT.RDF

 34 6 Tangerine2008_FT.RDF

 35 6 Lemon100%CT_FT.RDF

 36 6 Potato2008100CT_FT.RDF

 37 6 Honeydew.RDF

38 6 Goat, Horse, Sheep mbypd.RDF

 39 6 Goat, Horse, Sheep Fat.RDF

 40 6 Hog, Poultry m, mbypd.RDF

 41 6 Pepper, Chili 2008_FT.RDF

 42 6 Lettuce,leaf2008_FT.RDF

 43 6 Radicchio.RDF

 44 6 Spinach _FT.RDF

 45 6 Spinach100%_FT.RDF

 46 6 Cucumber_FT.RDF

 47 6 Tomato100%CT.RDF

 48 6 Cucumber100%CT_FT.RDF

 49 6 Summer squash100%CT_FT.RDF

 50 6 Nectarine.RDF

 51 6 Almond 100%CT.RDF
Abamectin Dietary Exposure Assessment D424009, D421348

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Page 31 of 60

 52 6 Pecan 100%CT.RDF

 53 6 Orange100%CTFT.RDF

 54 6 Blackberry.RDF

 55 6 Raspberry.RDF

 56 6 Plum (nonprune)2008.RDF

 57 6 Pistachio.RDF

 58 6 Sweet Corn.RDF

 59 6 Onion Bulb.RDF

 60 6 Aba_MSsoyb_MSsoybeanSTD_Reservoir_Parent_DEEM.rdf

 61 6 Grape100%CT.RDF

 62 6 Strawberry100%CT.RDF

 63 6 Apple100%CT.RDF

 64 6 Pear100%CT.RDF

 65 6 GHS Meat.RDF

 66 6 Papaya2015100CT_FT.RDF

 EPA Crop Commodity Name Def Res Adj.Factors RDLComment

 Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

0101084000 1AB Celeriac 0.017000 1.000 1.000 D26839

 Full comment: D268398, 45079901.der

0103015000 1CD Arrowroot, flour 0.002700 1.000 1.000 Blende

 Full comment: Blended

0103015001 1CD Arrowroot, flour-babyfood 0.002700 1.000 1.000 Blende

 Full comment: Blended

0103017000 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 36 

0103082000 1CD Cassava 0.010000 1.000 1.000 36 

0103082001 1CD Cassava-babyfood 0.010000 1.000 1.000 36 

0103139000 1CD Dasheen, corm 0.010000 1.000 1.000 36 

0103166000 1CD Ginger 0.010000 1.000 1.000 36 

0103166001 1CD Ginger-babyfood 0.010000 1.000 1.000 36 

0103167000 1CD Ginger, dried 0.002700 1.000 1.000 Blende

 Full comment: Blended

0103296000 1C Potato, chips 0.002700 1.000 0.200 Blende

 Full comment: Blended

0103297000 1C Potato, dry (granules/ flakes) 0.002700 6.500 0.200 Blende

 Full comment: Blended

0103297001 1C Potato, dry (granules/ flakes)-b 0.002700 6.500 0.200 Blende

 Full comment: Blended

0103298000 1C Potato, flour 0.002700 6.500 0.200 Blende

 Full comment: Blended

0103298001 1C Potato, flour-babyfood 0.002700 6.500 0.200 Blende

 Full comment: Blended

0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 20 FT (MR

 Full comment: FT (MRID 45096705)

0103299001 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 20 

0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 20 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 20 

0103366000 1CD Sweet potato 0.010000 1.000 1.000 36 

0103366001 1CD Sweet potato-babyfood 0.010000 1.000 1.000 36 

0103371000 1CD Tanier, corm 0.010000 1.000 1.000 36 

0103387000 1CD Turmeric 0.010000 1.000 1.000 36 

0103406000 1CD Yam, true 0.010000 1.000 1.000 36 

0103407000 1CD Yam bean 0.010000 1.000 1.000 36 

0301165000 3A Garlic, bulb 0.004600 1.000 1.000 D38079

 Full comment: D380795, MRID 48135001

0301165001 3A Garlic, bulb-babyfood 0.004600 1.000 1.000 D38079

 Full comment: D380795, MRID 48135001

0301237000 3A Onion, bulb 0.004600 1.000 1.000 59 D38079

 Full comment: D380795, MRID 48135001

0301237001 3A Onion, bulb-babyfood 0.004600 1.000 1.000 59 D38079

 Full comment: D380795, MRID 48135001

0301238000 3A Onion, bulb, dried 0.004000 9.000 0.100 Blende

 Full comment: Blended

0301238001 3A Onion, bulb, dried-babyfood 0.004000 9.000 0.100 Blende
Abamectin Dietary Exposure Assessment D424009, D421348

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Page 32 of 60

 Full comment: Blended

0301338000 3A Shallot, bulb 0.004600 1.000 1.000 D38079

 Full comment: D380795, MRID 48135001

0302103000 3B Chive, fresh leaves 0.004600 1.000 1.000 D38079

 Full comment: D380795, MRID 48135002

0302198000 3B Leek 0.004600 1.000 1.000 

0302239000 3B Onion, green 0.004600 1.000 1.000 D42400

 Full comment: D424008, MRID 49455902

0302338500 3B Shallot, fresh leaves 0.004600 1.000 1.000 

0401005000 4A Amaranth, leafy 0.100000 1.000 1.000 45 

0401018000 4A Arugula 0.100000 1.000 1.000 45 

0401104000 4A Chrysanthemum, garland 0.100000 1.000 1.000 45 

0401133000 4A Cress, garden 0.100000 1.000 1.000 45 

0401134000 4A Cress, upland 0.100000 1.000 1.000 45 

0401138000 4A Dandelion, leaves 0.100000 1.000 1.000 45 

0401150000 4A Endive 0.100000 1.000 1.000 45 

0401204000 4A Lettuce, head 0.100000 1.000 1.000 14 FT (D2

 Full comment: FT (D207554, MRID 45096702)

0401205000 4A Lettuce, leaf 0.100000 1.000 1.000 42 FT (D2

 Full comment: FT (D254546, 44708506)

0401248000 4A Parsley, leaves 0.100000 1.000 1.000 45 Spinac

 Full comment: Spinach FT (D254546, MRID 44708506)

0401313000 4A Radicchio 0.100000 1.000 1.000 43 

0401355000 4A Spinach 0.100000 1.000 1.000 44 FT (D2

 Full comment: FT (D254546, MRID 44708506)

0401355001 4A Spinach-babyfood 0.100000 1.000 1.000 44 

0402076000 4B Cardoon 0.100000 1.000 1.000 7 

0402085000 4B Celery 0.100000 1.000 1.000 8 FT (D

 Full comment: FT (D207554, MRID 45096102)

0402085001 4B Celery-babyfood 0.100000 1.000 1.000 8 

0402086000 4B Celery, juice 0.100000 1.000 1.000 8 

0402087000 4B Celtuce 0.100000 1.000 1.000 7 

0402152000 4B Fennel, Florence 0.100000 1.000 1.000 7 

0402322000 4B Rhubarb 0.100000 1.000 1.000 7 

0402367000 4B Swiss chard 0.100000 1.000 1.000 7 

0600347000 6 Soybean, seed 0.006000 1.000 0.110 Blende

 Full comment: Blended FT D414022, MRID 49071010

0600349000 6 Soybean, soy milk 0.006000 1.000 0.110 FT D41

 Full comment: FT D414022, MRID 49071010

0600349001 6 Soybean, soy milk-babyfood or in 0.006000 1.000 0.110 FT D41

 Full comment: FT D414022, MRID 49071010

0600350000 6 Soybean, oil 0.006000 1.000 0.110 FT D41

 Full comment: FT D414022, MRID 49071010

0600350001 6 Soybean, oil-babyfood 0.006000 1.000 0.110 FT D41

 Full comment: FT D414022, MRID 49071010

0601043000 6A Bean, snap, succulent 0.004000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.004000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.006000 1.000 0.110 FT D41

 Full comment: FT D414022, MRID 49071010

0602031000 6B Bean, broad, succulent 0.004000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.004000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.004000 1.000 1.000 

0603030000 6C Bean, black, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603032000 6C Bean, broad, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603034000 6C Bean, cowpea, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603035000 6C Bean, great northern, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603036000 6C Bean, kidney, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603038000 6C Bean, lima, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603039000 6C Bean, mung, seed 0.004100 1.000 0.025 D38079
Abamectin Dietary Exposure Assessment D424009, D421348

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Page 33 of 60

 Full comment: D380795, MRID 48135003

0603040000 6C Bean, navy, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603041000 6C Bean, pink, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603042000 6C Bean, pinto, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603098000 6C Chickpea, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603098001 6C Chickpea, seed-babyfood 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603099000 6C Chickpea, flour 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603182000 6C Guar, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603182001 6C Guar, seed-babyfood 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603348000 6C Soybean, flour 0.006000 1.000 0.110 D41402

 Full comment: D414022, MRID 49071010

0603348001 6C Soybean, flour-babyfood 0.006000 1.000 0.110 D41402

 Full comment: D414022, MRID 49071010

0801374000 8A Tomatillo 0.016000 1.000 1.000 47 

0801375000 8A Tomato 0.033000 1.000 1.000 22 FT (D2

 Full comment: FT (D207554, MRID 45096703)

0801375001 8A Tomato-babyfood 0.033000 1.000 1.000 22 

0801376000 8A Tomato, paste 0.033000 1.200 1.000 22 

0801376001 8A Tomato, paste-babyfood 0.033000 1.200 1.000 22 

0801377000 8A Tomato, puree 0.033000 0.400 1.000 22 

0801377001 8A Tomato, puree-babyfood 0.033000 0.400 1.000 22 

0801378000 8A Tomato, dried 0.017000 14.300 1.000 Blende

 Full comment: Blended

0801378001 8A Tomato, dried-babyfood 0.017000 14.300 1.000 Blende

 Full comment: Blended

0801379000 8A Tomato, juice 0.033000 0.210 1.000 22 

0801380000 8A Tomato, Tree 0.016000 1.000 1.000 47 

0802148000 8BC Eggplant 0.020000 1.000 1.000 9 

0802234000 8BC Okra 0.006000 1.000 1.000 D23832

 Full comment: D238327, MRID 44300002

0802270000 8B Pepper, bell 0.020000 1.000 1.000 19 FT (D2

 Full comment: FT (D206550, MRID 43334601)

0802270001 8B Pepper, bell-babyfood 0.020000 1.000 1.000 19 

0802271000 8B Pepper, bell, dried 0.003400 1.000 0.300 Blende

 Full comment: Blended

0802271001 8B Pepper, bell, dried-babyfood 0.003400 1.000 0.300 Blende

 Full comment: Blended

0802272000 8BC Pepper, nonbell 0.020000 1.000 1.000 41 FT (D2

 Full comment: FT (D238327, MRID 44300002)

0802272001 8BC Pepper, nonbell-babyfood 0.020000 1.000 1.000 41 

0802273000 8BC Pepper, nonbell, dried 0.004000 1.000 0.300 Blende

 Full comment: Blended

0901075000 9A Cantaloupe 0.005000 1.000 1.000 5 FT (D2

 Full comment: FT (D203373, MRID 43203801)

0901187000 9A Honeydew melon 0.005000 1.000 1.000 37 

0901399000 9A Watermelon 0.005000 1.000 1.000 32 FT (D2

 Full comment: FT (D203373, MRID 43203801)

0901400000 9A Watermelon, juice 0.005000 1.000 1.000 32 

0902021000 9B Balsam pear 0.005000 1.000 1.000 48 

0902088000 9B Chayote, fruit 0.005000 1.000 1.000 49 

0902102000 9B Chinese waxgourd 0.005000 1.000 1.000 48 

0902135000 9B Cucumber 0.005000 1.000 1.000 46 FT (D2

 Full comment: FT (D203373, MRID 43203801)

0902308000 9B Pumpkin 0.005000 1.000 1.000 3 

0902309000 9B Pumpkin, seed 0.005000 1.000 1.000 3 

0902356000 9B Squash, summer 0.005000 1.000 1.000 6 FT (MR

 Full comment: FT (MRID 43203801)
Abamectin Dietary Exposure Assessment D424009, D421348

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Page 34 of 60

0902356001 9B Squash, summer-babyfood 0.005000 1.000 1.000 6 

0902357000 9B Squash, winter 0.005000 1.000 1.000 6 

0902357001 9B Squash, winter-babyfood 0.005000 1.000 1.000 6 

1001106000 10A Citron 0.020000 1.000 1.000 53 

1001107000 10A Citrus hybrids 0.020000 1.000 1.000 53 

1001108000 10A Citrus, oil 0.004100 9.700 1.000 Blende

 Full comment: Blended

1001240000 10A Orange 0.020000 1.000 1.000 15 FT (D2

 Full comment: FT (D207554)

1001241000 10A Orange, juice 0.020000 0.250 1.000 15 

1001241001 10A Orange, juice-babyfood 0.020000 0.250 1.000 15 

1001242000 10A Orange, peel 0.020000 2.500 1.000 15 

1001369000 10A Tangerine 0.020000 1.000 1.000 34 FT (D2

 Full comment: FT (D207554)

1001370000 10A Tangerine, juice 0.020000 0.250 1.000 34 

1002197000 10B Kumquat 0.020000 1.000 1.000 53 

1002199000 10B Lemon 0.020000 1.000 1.000 33 FT (D2

 Full comment: FT (D207554)

1002200000 10B Lemon, juice 0.020000 0.250 1.000 33 

1002200001 10B Lemon, juice-babyfood 0.020000 0.250 1.000 33 

1002201000 10B Lemon, peel 0.020000 2.500 1.000 33 

1002206000 10B Lime 0.020000 1.000 1.000 35 

1002207000 10B Lime, juice 0.020000 0.250 1.000 35 

1002207001 10B Lime, juice-babyfood 0.020000 0.250 1.000 35 

1003180000 10C Grapefruit 0.020000 1.000 1.000 11 FT (D2

 Full comment: FT (D207554)

1003181000 10C Grapefruit, juice 0.020000 0.850 1.000 11 

1003307000 10C Pummelo 0.020000 1.000 1.000 10 

1100007000 11 Apple, fruit with peel 0.020000 1.000 1.000 2 FT (D

 Full comment: FT (D201328, D201333)

1100008000 11 Apple, peeled fruit 0.020000 1.000 1.000 2 

1100008001 11 Apple, peeled fruit-babyfood 0.020000 1.000 1.000 2 

1100009000 11 Apple, dried 0.003900 8.000 0.300 Blende

 Full comment: Blended

1100009001 11 Apple, dried-babyfood 0.003900 8.000 0.300 Blende

 Full comment: Blended

1100010000 11 Apple, juice 0.020000 0.073 1.000 2 

1100010001 11 Apple, juice-babyfood 0.020000 0.073 1.000 2 

1100011000 11 Apple, sauce 0.020000 1.000 1.000 2 

1100011001 11 Apple, sauce-babyfood 0.020000 1.000 1.000 2 

1100129000 11 Crabapple 0.020000 1.000 1.000 63 

1100173500 11 Goji berry 0.016000 1.000 1.000 47 

1100210000 11 Loquat 0.020000 1.000 1.000 64 

1100266000 11 Pear 0.020000 1.000 1.000 17 FT (D2

 Full comment: FT (D207554)

1100266001 11 Pear-babyfood 0.020000 1.000 1.000 17 

1100267000 11 Pear, dried 0.007400 6.250 0.850 Blende

 Full comment: Blended

1100268000 11 Pear, juice 0.020000 1.000 1.000 17 

1100268001 11 Pear, juice-babyfood 0.020000 1.000 1.000 17 

1100310000 11 Quince 0.020000 1.000 1.000 64 

1201090000 12A Cherry 0.090000 1.000 1.000 29 FT (MR

 Full comment: FT (MRID 450967-07, -08)

1201090001 12A Cherry-babyfood 0.090000 1.000 1.000 29 

1201091000 12A Cherry, juice 0.090000 1.500 1.000 29 

1201091001 12A Cherry, juice-babyfood 0.090000 1.500 1.000 29 

1202012000 12B Apricot 0.090000 1.000 1.000 31 

1202012001 12B Apricot-babyfood 0.090000 1.000 1.000 31 

1202013000 12B Apricot, dried 0.090000 6.000 1.000 31 

1202014000 12B Apricot, juice 0.090000 1.000 1.000 31 

1202014001 12B Apricot, juice-babyfood 0.090000 1.000 1.000 31 

1202230000 12B Nectarine 0.090000 1.000 1.000 50 

1202260000 12B Peach 0.090000 1.000 1.000 30 FT (MR

 Full comment: FT (MRID 450967-07, -08)

1202260001 12B Peach-babyfood 0.090000 1.000 1.000 30 
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Page 35 of 60

1202261000 12B Peach, dried 0.005700 7.000 0.250 Blende

 Full comment: Blended

1202261001 12B Peach, dried-babyfood 0.005700 7.000 0.250 Blende

 Full comment: Blended

1202262000 12B Peach, juice 0.090000 1.000 1.000 30 

1202262001 12B Peach, juice-babyfood 0.090000 1.000 1.000 30 

1203285000 12C Plum 0.090000 1.000 1.000 56 FT (MR

 Full comment: FT (MRID 44708503)

1203285001 12C Plum-babyfood 0.090000 1.000 1.000 56 

1203286000 12C Plum, prune, fresh 0.090000 1.000 1.000 18 FT (MR

 Full comment: FT (MRID 44708503)

1203286001 12C Plum, prune, fresh-babyfood 0.090000 1.000 1.000 18 

1203287000 12C Plum, prune, dried 0.090000 5.000 1.000 18 

1203287001 12C Plum, prune, dried-babyfood 0.090000 5.000 1.000 18 

1203288000 12C Plum, prune, juice 0.090000 1.400 1.000 18 

1203288001 12C Plum, prune, juice-babyfood 0.090000 1.400 1.000 18 

1301055000 13A Blackberry 0.200000 1.000 1.000 54 D41286

 Full comment: D412860, MRID 49080101

1301056000 13A Blackberry, juice 0.200000 1.000 1.000 54 

1301056001 13A Blackberry, juice-babyfood 0.200000 1.000 1.000 54 

1301058000 13A Boysenberry 0.200000 1.000 1.000 55 

1301208000 13A Loganberry 0.200000 1.000 1.000 55 

1301320000 13A Raspberry 0.200000 1.000 1.000 55 D41286

 Full comment: D412860, MRID 49080101

1301320001 13A Raspberry-babyfood 0.200000 1.000 1.000 55 

1301321000 13A Raspberry, juice 0.200000 1.000 1.000 55 

1301321001 13A Raspberry, juice-babyfood 0.200000 1.000 1.000 55 

1302057000 13B Blueberry 0.020000 1.000 1.000 62 13-07G

1302057001 13B Blueberry-babyfood 0.020000 1.000 1.000 62 

1302174000 13B Gooseberry 0.020000 1.000 1.000 61 13-07F

1304175000 13D Grape 0.020000 1.000 1.000 12 FT (MR

 Full comment: FT (MRID 44346001) 13-07F

1304176000 13D Grape, juice 0.020000 0.470 1.000 12 

1304176001 13D Grape, juice-babyfood 0.020000 0.470 1.000 12 

1304179000 13D Grape, wine and sherry 0.020000 1.000 1.000 12 

1307130000 13G Cranberry 0.020000 1.000 1.000 62 13-07G

1307130001 13G Cranberry-babyfood 0.020000 1.000 1.000 62 

1307131000 13G Cranberry, dried 0.020000 1.000 1.000 62 

1307132000 13G Cranberry, juice 0.020000 1.100 1.000 62 

1307132001 13G Cranberry, juice-babyfood 0.020000 1.100 1.000 62 

1307359000 13G Strawberry 0.020000 1.000 1.000 21 FT D4

 Full comment: FT D401832 13-07G

1307359001 13G Strawberry-babyfood 0.020000 1.000 1.000 21 

1307360000 13G Strawberry, juice 0.020000 1.000 1.000 21 

1307360001 13G Strawberry, juice-babyfood 0.020000 1.000 1.000 21 

1400003000 14 Almond 0.010000 1.000 1.000 1 FT (D1

 Full comment: FT (D163057, MRID 41822501)

1400003001 14 Almond-babyfood 0.010000 1.000 1.000 1 

1400004000 14 Almond, oil 0.001000 1.000 0.800 Blende

 Full comment: Blended

1400004001 14 Almond, oil-babyfood 0.001000 1.000 0.800 Blende

 Full comment: Blended

1400059000 14 Brazil nut 0.010000 1.000 1.000 52 

1400068000 14 Butternut 0.010000 1.000 1.000 52 

1400081000 14 Cashew 0.010000 1.000 1.000 52 

1400092000 14 Chestnut 0.010000 1.000 1.000 51 

1400155000 14 Hazelnut 0.010000 1.000 1.000 28 D31675

 Full comment: D316756, MRID 45096709

1400156000 14 Hazelnut, oil 0.005000 1.000 0.025 Blende

 Full comment: Blended

1400185000 14 Hickory nut 0.010000 1.000 1.000 52 

1400213000 14 Macadamia nut 0.010000 1.000 1.000 52 

1400269000 14 Pecan 0.010000 1.000 1.000 28 FT (MR

 Full comment: FT (MRID 45096709)

1400278000 14 Pine nut 0.010000 1.000 1.000 51 
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 36 of 60

1400282000 14 Pistachio 0.010000 1.000 1.000 57 

1400391000 14 Walnut 0.010000 1.000 1.000 23 FT (D1

 Full comment: FT (D163057, MRID 41822501)

1500127000 15 Corn, sweet 0.006000 1.000 1.000 58 FT D41

 Full comment: FT D414022, MRID 49071008

1500127001 15 Corn, sweet-babyfood 0.006000 1.000 1.000 58 FT D41

 Full comment: FT D414022, MRID 49071008

1901028000 19A Basil, fresh leaves 0.008000 1.000 1.000 FT (MR

 Full comment: FT (MRID 45871901)

1901028001 19A Basil, fresh leaves-babyfood 0.008000 1.000 1.000 

1901029000 19A Basil, dried leaves 0.019000 1.000 1.000 FT (MR

 Full comment: FT (MRID 45871901)

1901029001 19A Basil, dried leaves-babyfood 0.019000 1.000 1.000 

1901102500 19A Chive, dried leaves 0.004100 2.900 1.000 D38079

 Full comment: D380795, MRID 48135002

1901118000 19A Cilantro, leaves 0.008000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 0.008000 1.000 1.000 

1901144000 19A Dillweed 0.008000 1.000 1.000 

1901184000 19A Herbs, other 0.008000 1.000 1.000 

1901184001 19A Herbs, other-babyfood 0.008000 1.000 1.000 

1901202000 19A Lemongrass 0.008000 1.000 1.000 

1901220000 19A Marjoram 0.008000 1.000 1.000 

1901220001 19A Marjoram-babyfood 0.008000 1.000 1.000 

1901249000 19A Parsley, dried leaves 0.019000 1.000 1.000 Basil 

 Full comment: Basil FT (MRID 45871901)

1901249001 19A Parsley, dried leaves-babyfood 0.019000 1.000 1.000 

1901334000 19A Savory 0.008000 1.000 1.000 

2003114001 20C Coconut, oil-babyfood 0.010000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.007000 1.000 0.300 FT (D4

 Full comment: FT (D401832) Blended

2003128001 20C Cottonseed, oil-babyfood 0.007000 1.000 0.300 FT (D4

 Full comment: FT (D401832) Blended

3100044000 31 Beef, meat 0.008400 1.000 1.000 25 D34480

 Full comment: D344808

3100044001 31 Beef, meat-babyfood 0.008400 1.000 1.000 25 

3100045000 31 Beef, meat, dried 0.008400 1.920 1.000 25 

3100046000 31 Beef, meat byproducts 0.076000 1.000 1.000 26 D34480

 Full comment: D344808

3100046001 31 Beef, meat byproducts-babyfood 0.076000 1.000 1.000 26 

3100047000 31 Beef, fat 0.038000 1.000 1.000 24 D34480

 Full comment: D344808

3100047001 31 Beef, fat-babyfood 0.038000 1.000 1.000 24 

3100048000 31 Beef, kidney 0.026000 1.000 1.000 26 

3100049000 31 Beef, liver 0.076000 1.000 1.000 26 

3100049001 31 Beef, liver-babyfood 0.076000 1.000 1.000 26 

3200169000 32 Goat, meat 0.002400 1.000 1.000 65 D34480

 Full comment: D344808

3200170000 32 Goat, meat byproducts 0.024000 1.000 1.000 38 

3200171000 32 Goat, fat 0.017000 1.000 1.000 39 

3200172000 32 Goat, kidney 0.006000 1.000 1.000 38 

3200173000 32 Goat, liver 0.024000 1.000 1.000 38 

3300189000 33 Horse, meat 0.002400 1.000 1.000 65 D34480

 Full comment: D344808

3400290000 34 Pork, meat 0.020000 1.000 1.000 40 D34480

 Full comment: D344808

3400290001 34 Pork, meat-babyfood 0.020000 1.000 1.000 40 

3400291000 34 Pork, skin 0.020000 1.000 1.000 40 

3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000 40 

3400292001 34 Pork, meat byproducts-babyfood 0.020000 1.000 1.000 40 

3400293000 34 Pork, fat 0.010000 1.000 1.000 27 

3400293001 34 Pork, fat-babyfood 0.010000 1.000 1.000 27 

3400294000 34 Pork, kidney 0.020000 1.000 1.000 40 

3400295000 34 Pork, liver 0.020000 1.000 1.000 40 

3500339000 35 Sheep, meat 0.002400 1.000 1.000 65 D34480

 Full comment: D344808
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 37 of 60

3500339001 35 Sheep, meat-babyfood 0.002400 1.000 1.000 65 

3500340000 35 Sheep, meat byproducts 0.024000 1.000 1.000 38 

3500341000 35 Sheep, fat 0.017000 1.000 1.000 39 

3500341001 35 Sheep, fat-babyfood 0.017000 1.000 1.000 39 

3500342000 35 Sheep, kidney 0.006000 1.000 1.000 38 

3500343000 35 Sheep, liver 0.024000 1.000 1.000 38 

3600222000 36 Milk, fat 0.011000 1.000 1.000 16 D34480

 Full comment: D344808

3600222001 36 Milk, fat-baby food/infant formu 0.011000 1.000 1.000 16 

3600223000 36 Milk, nonfat solids 0.011000 1.000 1.000 16 

3600223001 36 Milk, nonfat solids-baby food/in 0.011000 1.000 1.000 16 

3600224000 36 Milk, water 0.011000 1.000 1.000 16 

3600224001 36 Milk, water-babyfood/infant form 0.011000 1.000 1.000 16 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.011000 1.000 1.000 16 

4000093000 40 Chicken, meat 0.020000 1.000 1.000 40 D34480

 Full comment: D344808

4000093001 40 Chicken, meat-babyfood 0.020000 1.000 1.000 40 

4000094000 40 Chicken, liver 0.020000 1.000 1.000 40 

4000095000 40 Chicken, meat byproducts 0.020000 1.000 1.000 40 

4000095001 40 Chicken, meat byproducts-babyfoo 0.020000 1.000 1.000 40 

4000097000 40 Chicken, skin 0.020000 1.000 1.000 40 

4000097001 40 Chicken, skin-babyfood 0.020000 1.000 1.000 40 

5000382000 50 Turkey, meat 0.020000 1.000 1.000 40 D34480

 Full comment: D344808

5000382001 50 Turkey, meat-babyfood 0.020000 1.000 1.000 40 

5000383000 50 Turkey, liver 0.020000 1.000 1.000 40 

5000383001 50 Turkey, liver-babyfood 0.020000 1.000 1.000 40 

5000384000 50 Turkey, meat byproducts 0.020000 1.000 1.000 40 

5000384001 50 Turkey, meat byproducts-babyfood 0.020000 1.000 1.000 40 

5000386000 50 Turkey, skin 0.020000 1.000 1.000 40 

5000386001 50 Turkey, skin-babyfood 0.020000 1.000 1.000 40 

6000301000 60 Poultry, other, meat 0.020000 1.000 1.000 40 D34480

 Full comment: D344808

6000302000 60 Poultry, other, liver 0.020000 1.000 1.000 40 

6000303000 60 Poultry, other, meat byproducts 0.020000 1.000 1.000 40 

6000305000 60 Poultry, other, skin 0.020000 1.000 1.000 40 

8601000000 86A Water, direct, all sources 0.000760 1.000 1.000 60 

8602000000 86B Water, indirect, all sources 0.000760 1.000 1.000 60 

9500001000 O Acerola 0.005000 1.000 1.000 D42400

 Full comment: D424008

9500020000 O Avocado 0.020000 1.000 1.000 4 FT (MR

 Full comment: FT (MRID 45083501)

9500074000 O Canistel 0.131000 1.000 1.000 

9500111000 O Coconut, meat 0.010000 1.000 1.000 

9500111001 O Coconut, meat-babyfood 0.010000 1.000 1.000 

9500112000 O Coconut, dried 0.010000 2.100 1.000 Defaul

 Full comment: Default PF

9500113000 O Coconut, milk 0.010000 1.000 1.000 

9500114000 O Coconut, oil 0.010000 1.000 1.000 

9500151000 O Feijoa 0.005000 1.000 1.000 D42400

 Full comment: D424008

9500177000 O Grape, leaves 0.020000 1.000 1.000 12 

9500178000 O Grape, raisin 0.020000 0.750 1.000 13 MRID 4

 Full comment: MRID 44346001

9500183000 O Guava 0.005000 1.000 1.000 D42400

 Full comment: D424008, MRID 49455903

9500183001 O Guava-babyfood 0.005000 1.000 1.000 

9500188000 O Hop 0.051000 1.000 1.000 FT (MR

 Full comment: FT (MRID 43733101)

9500209000 O Longan 0.002700 1.000 1.000 

9500211000 O Lychee 0.002700 1.000 1.000 D42400

 Full comment: D424008, MRID 49455905

9500212000 O Lychee, dried 0.002400 1.850 1.000 Blende

 Full comment: Blended

9500245000 O Papaya 0.131000 1.000 1.000 66 D42400
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 38 of 60

 Full comment: D424008, MRID 49455906

9500245001 O Papaya-babyfood 0.131000 1.000 1.000 66 

9500246000 O Papaya, dried 0.086300 1.800 1.000 Blende

 Full comment: Blended

9500247000 O Papaya, juice 0.131000 1.500 1.000 66 

9500252000 O Passionfruit 0.005000 1.000 1.000 D42400

 Full comment: D424008

9500252001 O Passionfruit-babyfood 0.005000 1.000 1.000 

9500253000 O Passionfruit, juice 0.005000 1.000 1.000 

9500253001 O Passionfruit, juice-babyfood 0.005000 1.000 1.000 

9500275000 O Peppermint 0.047000 1.000 1.000 FT (MR

 Full comment: FT (MRID 45096706)

9500276000 O Peppermint, oil 0.047000 1.000 1.000 

9500279000 O Pineapple 0.004000 1.000 1.000 

9500279001 O Pineapple-babyfood 0.004000 1.000 1.000 

9500280000 O Pineapple, dried 0.004000 5.000 1.000 Blende

 Full comment: Blended

9500281000 O Pineapple, juice 0.004000 1.700 1.000 

9500281001 O Pineapple, juice-babyfood 0.004000 1.700 1.000 

9500333000 O Sapote, Mamey 0.131000 1.000 1.000 D42400

 Full comment: D424008

9500351000 O Spanish lime 0.002700 1.000 1.000 D42400

 Full comment: D424008

9500352000 O Spearmint 0.047000 1.000 1.000 FT (MR

 Full comment: FT (MRID 45096706)

9500353000 O Spearmint, oil 0.047000 1.000 1.000 

9500358000 O Starfruit 0.005000 1.000 1.000 D42400

 Full comment: D424008
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 39 of 60

Attachment 4: Acute Food plus Water Results File

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for AVERMECTIN NHANES 2003-2008 2-Day

Residue file: Abamectin acute Food and Water PRIA 3 29 16.R08

 Adjustment factor #2 used.

Analysis Date: 03-29-2016/12:38:49 Residue file dated: 03-29-2016/12:31:57

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: "Food and Water at 0.76 ppb; Updated 3/23/16"

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population: 0.000228 9.11 0.000548 21.90 0.001135 45.39 

All Infants: 0.000391 15.63 0.001077 43.07 0.001584 63.37 

Children 1-2: 0.000959 38.38 0.001402 56.09 0.002192 87.68 

Children 3-5: 0.000554 22.15 0.000789 31.56 0.001553 62.10 

Children 6-12: 0.000341 13.65 0.000497 19.87 0.000729 29.15 

Youth 13-19: 0.000173 6.93 0.000286 11.43 0.000475 18.99 

Adults 20-49: 0.000132 5.27 0.000219 8.78 0.000446 17.83 

Adults 50-99: 0.000122 4.87 0.000199 7.96 0.000345 13.78 

Female 13-49: 0.000134 5.37 0.000229 9.16 0.000427 17.10 

Attachment 5: Acute Food Only Results File

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for AVERMECTIN NHANES 2003-2008 2-Day

Residue file: Abamectin acute Food only PRIA 3 29 16.R08

 Adjustment factor #2 used.

Analysis Date: 03-29-2016/13:07:16 Residue file dated: 03-29-2016/13:00:48

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: "Food only; Updated 3/29/16"

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population: 0.000225 8.99 0.000544 21.77 0.001131 45.25 

All Infants: 0.000378 15.11 0.001070 42.80 0.001581 63.23 

Children 1-2: 0.000955 38.19 0.001395 55.82 0.002188 87.53 

Children 3-5: 0.000549 21.97 0.000784 31.36 0.001558 62.32 

Children 6-12: 0.000339 13.57 0.000494 19.76 0.000725 29.01 

Youth 13-19: 0.000171 6.84 0.000284 11.36 0.000471 18.84 

Adults 20-49: 0.000128 5.13 0.000216 8.63 0.000446 17.84 

Adults 50-99: 0.000119 4.74 0.000196 7.83 0.000340 13.61 

Female 13-49: 0.000131 5.23 0.000226 9.03 0.000427 17.06 
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 40 of 60

Attachment 6: Chronic Food plus Water Residue Input File

Filename: C:\Users\KRURY\Documents\My Work Files\Abamectin\Dietary Files\Abamectin chronic 

PRIA 3 29 16.R08

Chemical: Avermectin

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 03-29-2016/09:11:57 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 0.000200 1.000 0.050 FHE = 

 Full comment: FHE = Food Handling Establishment

0101050001 1AB Beet, garden, roots-babyfood 0.000200 1.000 0.050 FHE

0101052000 1A Beet, sugar 0.000200 1.000 0.050 FHE

0101052001 1A Beet, sugar-babyfood 0.000200 1.000 0.050 FHE

0101053000 1A Beet, sugar, molasses 0.000200 1.000 0.050 FHE

0101053001 1A Beet, sugar, molasses-babyfood 0.000200 1.000 0.050 FHE

0101067000 1AB Burdock 0.000200 1.000 0.050 FHE

0101078000 1AB Carrot 0.000200 1.000 0.050 FHE

0101078001 1AB Carrot-babyfood 0.000200 1.000 0.050 FHE

0101079000 1AB Carrot, juice 0.000200 1.000 0.050 FHE

0101084000 1AB Celeriac 0.006200 1.000 1.000 

0101100000 1AB Chicory, roots 0.000200 1.000 0.050 FHE

0101168000 1AB Ginseng, dried 0.000200 1.000 0.050 FHE

0101190000 1AB Horseradish 0.000200 1.000 0.050 FHE

0101250000 1AB Parsley, turnip rooted 0.000200 1.000 0.050 FHE

0101251000 1AB Parsnip 0.000200 1.000 0.050 FHE

0101251001 1AB Parsnip-babyfood 0.000200 1.000 0.050 FHE

0101314000 1AB Radish, roots 0.000200 1.000 0.050 FHE

0101316000 1AB Radish, Oriental, roots 0.000200 1.000 0.050 FHE

0101327000 1AB Rutabaga 0.000200 1.000 0.050 FHE

0101331000 1AB Salsify, roots 0.000200 1.000 0.050 FHE

0101388000 1AB Turnip, roots 0.000200 1.000 0.050 FHE

0103015000 1CD Arrowroot, flour 0.002700 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.002700 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.002700 1.000 1.000 

0103082000 1CD Cassava 0.002700 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.002700 1.000 1.000 

0103139000 1CD Dasheen, corm 0.002700 1.000 1.000 

0103166000 1CD Ginger 0.002700 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.002700 1.000 1.000 

0103167000 1CD Ginger, dried 0.002700 1.000 1.000 

0103296000 1C Potato, chips 0.002700 1.000 0.050 FT

0103297000 1C Potato, dry (granules/ flakes) 0.002700 6.500 0.050 FT

0103297001 1C Potato, dry (granules/ flakes)-b 0.002700 6.500 0.050 FT

0103298000 1C Potato, flour 0.002700 6.500 0.050 FT

0103298001 1C Potato, flour-babyfood 0.002700 6.500 0.050 FT

0103299000 1C Potato, tuber, w/peel 0.002700 1.000 0.050 FT

0103299001 1C Potato, tuber, w/peel-babyfood 0.002700 1.000 0.050 FT

0103300000 1C Potato, tuber, w/o peel 0.002700 1.000 0.050 FT

0103300001 1C Potato, tuber, w/o peel-babyfood 0.002700 1.000 0.050 FT

0103366000 1CD Sweet potato 0.002700 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.002700 1.000 1.000 

0103371000 1CD Tanier, corm 0.002700 1.000 1.000 

0103387000 1CD Turmeric 0.002700 1.000 1.000 

0103406000 1CD Yam, true 0.002700 1.000 1.000 

0103407000 1CD Yam bean 0.002700 1.000 1.000 

0200051000 2 Beet, garden, tops 0.000200 1.000 0.050 FHE

0200101000 2 Chicory, tops 0.000200 1.000 0.050 FHE

0200140000 2 Dasheen, leaves 0.000200 1.000 0.050 FHE

0200315000 2 Radish, tops 0.000200 1.000 0.050 FHE

0200317000 2 Radish, Oriental, tops 0.000200 1.000 0.050 FHE
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 41 of 60

0200332000 2 Salsify, tops 0.000200 1.000 0.050 FHE

0301165000 3A Garlic, bulb 0.004000 1.000 1.000 D38079

 Full comment: D380795, MRID 48135001

0301165001 3A Garlic, bulb-babyfood 0.004000 1.000 1.000 D38079

 Full comment: D380795, MRID 48135001

0301237000 3A Onion, bulb 0.004000 1.000 0.025 D38079

 Full comment: D380795, MRID 48135001

0301237001 3A Onion, bulb-babyfood 0.004000 1.000 0.025 D38079

 Full comment: D380795, MRID 48135001

0301238000 3A Onion, bulb, dried 0.004000 9.000 0.025 D38079

 Full comment: D380795, MRID 48135001

0301238001 3A Onion, bulb, dried-babyfood 0.004000 9.000 0.025 D38079

 Full comment: D380795, MRID 48135001

0301338000 3A Shallot, bulb 0.004000 1.000 1.000 D38079

 Full comment: D380795, MRID 48135001

0302103000 3B Chive, fresh leaves 0.004000 1.000 1.000 D38079

 Full comment: D380795, MRID 48135002, fresh

0302198000 3B Leek 0.004000 1.000 1.000 

0302239000 3B Onion, green 0.004000 1.000 1.000 D42400

 Full comment: D424008, MRID 49455902

0302338500 3B Shallot, fresh leaves 0.004000 1.000 1.000 

0401005000 4A Amaranth, leafy 0.044000 1.000 1.000 

0401018000 4A Arugula 0.044000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 0.044000 1.000 1.000 

0401133000 4A Cress, garden 0.044000 1.000 1.000 

0401134000 4A Cress, upland 0.044000 1.000 1.000 

0401138000 4A Dandelion, leaves 0.044000 1.000 1.000 

0401150000 4A Endive 0.044000 1.000 1.000 

0401204000 4A Lettuce, head 0.008600 1.000 0.200 

0401205000 4A Lettuce, leaf 0.023000 1.000 0.200 

0401248000 4A Parsley, leaves 0.044000 1.000 1.000 

0401313000 4A Radicchio 0.008600 1.000 1.000 

0401355000 4A Spinach 0.044000 1.000 0.250 

0401355001 4A Spinach-babyfood 0.044000 1.000 0.250 

0402076000 4B Cardoon 0.014000 1.000 1.000 

0402085000 4B Celery 0.014000 1.000 0.450 FT

0402085001 4B Celery-babyfood 0.014000 1.000 0.450 

0402086000 4B Celery, juice 0.014000 1.000 0.450 

0402087000 4B Celtuce 0.014000 1.000 1.000 

0402152000 4B Fennel, Florence 0.014000 1.000 1.000 

0402322000 4B Rhubarb 0.014000 1.000 1.000 

0402367000 4B Swiss chard 0.014000 1.000 1.000 

0501061000 5A Broccoli 0.000200 1.000 0.050 FHE

0501061001 5A Broccoli-babyfood 0.000200 1.000 0.050 FHE

0501062000 5A Broccoli, Chinese 0.000200 1.000 0.050 FHE

0501064000 5A Brussels sprouts 0.000200 1.000 0.050 FHE

0501069000 5A Cabbage 0.000200 1.000 0.050 FHE

0501071000 5A Cabbage, Chinese, napa 0.000200 1.000 0.050 FHE

0501072000 5A Cabbage, Chinese, mustard 0.000200 1.000 0.050 FHE

0501083000 5A Cauliflower 0.000200 1.000 0.050 FHE

0501196000 5A Kohlrabi 0.000200 1.000 0.050 FHE

0502063000 5B Broccoli raab 0.000200 1.000 0.050 FHE

0502070000 5B Cabbage, Chinese, bok choy 0.000200 1.000 0.050 FHE

0502117000 5B Collards 0.000200 1.000 0.050 FHE

0502194000 5B Kale 0.000200 1.000 0.050 FHE

0502229000 5B Mustard greens 0.000200 1.000 0.050 FHE

0502318000 5B Rape greens 0.000200 1.000 0.050 FHE

0502389000 5B Turnip, greens 0.000200 1.000 0.050 FHE

0600347000 6 Soybean, seed 0.006000 1.000 0.080 FT MRI

 Full comment: FT MRID 49071010

0600349000 6 Soybean, soy milk 0.006000 1.000 0.080 FT MRI

 Full comment: FT MRID 49071010

0600349001 6 Soybean, soy milk-babyfood or in 0.006000 1.000 0.080 FT MRI

 Full comment: FT MRID 49071010

0600350000 6 Soybean, oil 0.006000 1.000 0.080 FT MRI
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 42 of 60

 Full comment: FT MRID 49071010

0600350001 6 Soybean, oil-babyfood 0.006000 1.000 0.080 FT MRI

 Full comment: FT MRID 49071010

0601043000 6A Bean, snap, succulent 0.004000 1.000 1.000 D38079

 Full comment: D380795, MRID 48135008

0601043001 6A Bean, snap, succulent-babyfood 0.004000 1.000 1.000 D38079

 Full comment: D380795, MRID 48135008

0601257000 6A Pea, edible podded, succulent 0.000200 1.000 0.050 FHE

0601349500 6AB Soybean, vegetable 0.006000 1.000 0.080 FT MRI

 Full comment: FT MRID 49071010

0602031000 6B Bean, broad, succulent 0.004000 1.000 1.000 D42400

 Full comment: D424008

0602033000 6B Bean, cowpea, succulent 0.004000 1.000 1.000 D42400

 Full comment: D424008

0602037000 6B Bean, lima, succulent 0.004000 1.000 1.000 D42400

 Full comment: D424008, MRID 49455904

0602255000 6B Pea, succulent 0.000200 1.000 0.050 FHE

0602255001 6B Pea, succulent-babyfood 0.000200 1.000 0.050 FHE

0602259000 6B Pea, pigeon, succulent 0.000200 1.000 0.050 FHE

0603030000 6C Bean, black, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48134003

0603032000 6C Bean, broad, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603034000 6C Bean, cowpea, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603035000 6C Bean, great northern, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603036000 6C Bean, kidney, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603038000 6C Bean, lima, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603039000 6C Bean, mung, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603040000 6C Bean, navy, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603041000 6C Bean, pink, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603042000 6C Bean, pinto, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603098000 6C Chickpea, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603098001 6C Chickpea, seed-babyfood 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603099000 6C Chickpea, flour 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603182000 6C Guar, seed 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603182001 6C Guar, seed-babyfood 0.004100 1.000 0.025 D38079

 Full comment: D380795, MRID 48135003

0603203000 6C Lentil, seed 0.000200 1.000 0.050 FHE

0603256000 6C Pea, dry 0.000200 1.000 0.050 FHE

0603256001 6C Pea, dry-babyfood 0.000200 1.000 0.050 FHE

0603258000 6C Pea, pigeon, seed 0.000200 1.000 0.050 FHE

0603348000 6C Soybean, flour 0.006000 1.000 0.080 FT MRI

 Full comment: FT MRID 49071010

0603348001 6C Soybean, flour-babyfood 0.006000 1.000 0.080 FT MRI

 Full comment: FT MRID 49071010

0801374000 8A Tomatillo 0.002700 1.000 1.000 Tomato

 Full comment: Tomato FT

0801375000 8A Tomato 0.017000 1.000 0.100 Greenh

 Full comment: Greenhouse

0801375001 8A Tomato-babyfood 0.017000 1.000 0.100 

0801376000 8A Tomato, paste 0.017000 1.200 0.100 

0801376001 8A Tomato, paste-babyfood 0.017000 1.200 0.100 

0801377000 8A Tomato, puree 0.017000 0.400 0.100 
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 43 of 60

0801377001 8A Tomato, puree-babyfood 0.017000 0.400 0.100 

0801378000 8A Tomato, dried 0.017000 14.300 0.100 

0801378001 8A Tomato, dried-babyfood 0.017000 14.300 0.100 

0801379000 8A Tomato, juice 0.017000 0.210 0.100 

0801380000 8A Tomato, Tree 0.002700 1.000 1.000 Tomato

 Full comment: Tomato FT

0802148000 8BC Eggplant 0.003400 1.000 1.000 

0802234000 8BC Okra 0.004000 1.000 1.000 

0802270000 8B Pepper, bell 0.003400 1.000 0.150 FT

0802270001 8B Pepper, bell-babyfood 0.003400 1.000 0.150 

0802271000 8B Pepper, bell, dried 0.003400 1.000 0.150 

0802271001 8B Pepper, bell, dried-babyfood 0.003400 1.000 0.150 

0802272000 8BC Pepper, nonbell 0.004000 1.000 0.150 FT

0802272001 8BC Pepper, nonbell-babyfood 0.004000 1.000 0.150 

0802273000 8BC Pepper, nonbell, dried 0.004000 1.000 0.150 

0901075000 9A Cantaloupe 0.002000 1.000 0.250 D20337

 Full comment: D203373, MRID 43203801

0901187000 9A Honeydew melon 0.002000 1.000 0.200 

0901399000 9A Watermelon 0.002000 1.000 0.050 FT

0901400000 9A Watermelon, juice 0.002000 1.000 0.050 FT

0902021000 9B Balsam pear 0.002200 1.000 1.000 

0902088000 9B Chayote, fruit 0.002000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.002200 1.000 1.000 

0902135000 9B Cucumber 0.002200 1.000 0.050 FT

0902308000 9B Pumpkin 0.002000 1.000 0.050 

0902309000 9B Pumpkin, seed 0.002000 1.000 0.050 

0902356000 9B Squash, summer 0.002000 1.000 0.050 FT

0902356001 9B Squash, summer-babyfood 0.002000 1.000 0.050 

0902357000 9B Squash, winter 0.002000 1.000 0.050 

0902357001 9B Squash, winter-babyfood 0.002000 1.000 0.050 

1001106000 10A Citron 0.004100 1.000 1.000 

1001107000 10A Citrus hybrids 0.004100 1.000 1.000 

1001108000 10A Citrus, oil 0.004100 9.700 1.000 D20755

 Full comment: D207554

1001240000 10A Orange 0.004100 1.000 0.400 

1001241000 10A Orange, juice 0.004100 0.250 0.400 D20755

 Full comment: D207554

1001241001 10A Orange, juice-babyfood 0.004100 0.250 0.400 

1001242000 10A Orange, peel 0.004100 2.500 0.400 D20755

 Full comment: D207554

1001369000 10A Tangerine 0.003500 1.000 0.350 

1001370000 10A Tangerine, juice 0.003500 0.250 0.350 D20755

 Full comment: D207554

1002197000 10B Kumquat 0.004100 1.000 1.000 

1002199000 10B Lemon 0.001250 1.000 0.400 

1002200000 10B Lemon, juice 0.001250 0.250 0.400 

1002200001 10B Lemon, juice-babyfood 0.001250 0.250 0.400 

1002201000 10B Lemon, peel 0.001250 2.500 0.400 D20755

 Full comment: D207554

1002206000 10B Lime 0.001250 1.000 1.000 

1002207000 10B Lime, juice 0.001250 0.250 1.000 D20755

 Full comment: D207554

1002207001 10B Lime, juice-babyfood 0.001250 0.250 1.000 

1003180000 10C Grapefruit 0.001250 1.000 0.700 

1003181000 10C Grapefruit, juice 0.001250 0.850 0.700 D20755

 Full comment: D207554

1003307000 10C Pummelo 0.001250 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.003900 1.000 0.100 FT 

1100008000 11 Apple, peeled fruit 0.003900 1.000 0.100 

1100008001 11 Apple, peeled fruit-babyfood 0.003900 1.000 0.100 

1100009000 11 Apple, dried 0.003900 8.000 0.100 

1100009001 11 Apple, dried-babyfood 0.003900 8.000 0.100 

1100010000 11 Apple, juice 0.003900 0.073 0.100 

1100010001 11 Apple, juice-babyfood 0.003900 0.073 0.100 

1100011000 11 Apple, sauce 0.003900 1.000 0.100 
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 44 of 60

1100011001 11 Apple, sauce-babyfood 0.003900 1.000 0.100 

1100129000 11 Crabapple 0.003900 1.000 1.000 

1100173500 11 Goji berry 0.002700 1.000 1.000 CG8 To

 Full comment: CG8 Tomato FT

1100210000 11 Loquat 0.007400 1.000 1.000 

1100266000 11 Pear 0.007400 1.000 0.700 FT

1100266001 11 Pear-babyfood 0.007400 1.000 0.700 

1100267000 11 Pear, dried 0.007400 6.250 0.700 

1100268000 11 Pear, juice 0.007400 1.000 0.700 

1100268001 11 Pear, juice-babyfood 0.007400 1.000 0.700 

1100310000 11 Quince 0.007400 1.000 1.000 

1201090000 12A Cherry 0.016000 1.000 0.050 

1201090001 12A Cherry-babyfood 0.016000 1.000 0.050 

1201091000 12A Cherry, juice 0.016000 1.500 0.050 

1201091001 12A Cherry, juice-babyfood 0.016000 1.500 0.050 

1202012000 12B Apricot 0.005700 1.000 0.150 

1202012001 12B Apricot-babyfood 0.005700 1.000 0.150 peach 

 Full comment: peach transl

1202013000 12B Apricot, dried 0.005700 6.000 0.150 

1202014000 12B Apricot, juice 0.005700 1.000 0.150 

1202014001 12B Apricot, juice-babyfood 0.005700 1.000 0.150 

1202230000 12B Nectarine 0.005700 1.000 0.200 

1202260000 12B Peach 0.005700 1.000 0.100 FT

1202260001 12B Peach-babyfood 0.005700 1.000 0.100 FT

1202261000 12B Peach, dried 0.005700 7.000 0.100 FT

1202261001 12B Peach, dried-babyfood 0.005700 7.000 0.100 FT

1202262000 12B Peach, juice 0.005700 1.000 0.100 FT

1202262001 12B Peach, juice-babyfood 0.005700 1.000 0.100 FT

1203285000 12C Plum 0.002000 1.000 1.000 

1203285001 12C Plum-babyfood 0.002000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.002000 1.000 0.100 FT

1203286001 12C Plum, prune, fresh-babyfood 0.002000 1.000 0.100 

1203287000 12C Plum, prune, dried 0.002000 5.000 0.100 

1203287001 12C Plum, prune, dried-babyfood 0.002000 5.000 0.100 

1203288000 12C Plum, prune, juice 0.002000 1.400 0.100 

1203288001 12C Plum, prune, juice-babyfood 0.002000 1.400 0.100 

1301055000 13A Blackberry 0.029300 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1301056000 13A Blackberry, juice 0.029300 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1301056001 13A Blackberry, juice-babyfood 0.029300 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1301058000 13A Boysenberry 0.045500 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1301208000 13A Loganberry 0.045500 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1301320000 13A Raspberry 0.044500 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1301320001 13A Raspberry-babyfood 0.044500 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1301321000 13A Raspberry, juice 0.044500 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1301321001 13A Raspberry, juice-babyfood 0.044500 1.000 0.560 FT MRI

 Full comment: FT MRID 49080101

1302057000 13B Blueberry 0.017000 1.000 1.000 13-07G

1302057001 13B Blueberry-babyfood 0.017000 1.000 1.000 

1302136000 13B Currant 0.000200 1.000 0.050 FHE

1302137000 13B Currant, dried 0.000200 1.000 0.050 FHE

1302149000 13B Elderberry 0.000200 1.000 0.050 FHE

1302174000 13B Gooseberry 0.002300 1.000 1.000 13-07F

1302191000 13B Huckleberry 0.000200 1.000 0.050 FHE

1303227000 13C Mulberry 0.000200 1.000 0.050 FHE

1304175000 13D Grape 0.002300 1.000 0.150 FT

1304176000 13D Grape, juice 0.002300 0.470 0.150 FT

1304176001 13D Grape, juice-babyfood 0.002300 0.470 0.150 FT
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 45 of 60

1304179000 13D Grape, wine and sherry 0.002300 1.000 0.150 FT

1304195000 13D Kiwifruit, fuzzy 0.000200 1.000 0.050 FHE

1307130000 13G Cranberry 0.017000 1.000 1.000 13-07G

1307130001 13G Cranberry-babyfood 0.017000 1.000 1.000 

1307131000 13G Cranberry, dried 0.017000 1.000 1.000 

1307132000 13G Cranberry, juice 0.017000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.017000 1.100 1.000 

1307359000 13G Strawberry 0.017000 1.000 0.300 

1307359001 13G Strawberry-babyfood 0.017000 1.000 0.300 

1307360000 13G Strawberry, juice 0.017000 1.000 0.300 

1307360001 13G Strawberry, juice-babyfood 0.017000 1.000 0.300 

1400003000 14 Almond 0.001000 1.000 0.700 

1400003001 14 Almond-babyfood 0.001000 1.000 0.700 

1400004000 14 Almond, oil 0.001000 1.000 0.700 

1400004001 14 Almond, oil-babyfood 0.001000 1.000 0.700 

1400059000 14 Brazil nut 0.005000 1.000 1.000 

1400068000 14 Butternut 0.005000 1.000 1.000 

1400081000 14 Cashew 0.005000 1.000 1.000 

1400092000 14 Chestnut 0.001000 1.000 1.000 

1400155000 14 Hazelnut 0.005000 1.000 0.025 

1400156000 14 Hazelnut, oil 0.005000 1.000 0.025 

1400185000 14 Hickory nut 0.005000 1.000 1.000 

1400213000 14 Macadamia nut 0.005000 1.000 1.000 

1400269000 14 Pecan 0.005000 1.000 0.010 FT

1400278000 14 Pine nut 0.001000 1.000 1.000 

1400282000 14 Pistachio 0.001000 1.000 0.025 

1400391000 14 Walnut 0.001000 1.000 0.250 FT

1500025000 15 Barley, pearled barley 0.000200 1.000 0.050 FHE

1500025001 15 Barley, pearled barley-babyfood 0.000200 1.000 0.050 FHE

1500026000 15 Barley, flour 0.000200 1.000 0.050 FHE

1500026001 15 Barley, flour-babyfood 0.000200 1.000 0.050 FHE

1500027000 15 Barley, bran 0.000200 1.000 0.050 FHE

1500065000 15 Buckwheat 0.000200 1.000 0.050 FHE

1500066000 15 Buckwheat, flour 0.000200 1.000 0.050 FHE

1500120000 15 Corn, field, flour 0.000200 1.000 0.050 FHE

1500120001 15 Corn, field, flour-babyfood 0.000200 1.000 0.050 FHE

1500121000 15 Corn, field, meal 0.000200 1.000 0.050 FHE

1500121001 15 Corn, field, meal-babyfood 0.000200 1.000 0.050 FHE

1500122000 15 Corn, field, bran 0.000200 1.000 0.050 FHE

1500123000 15 Corn, field, starch 0.000200 1.000 0.050 FHE

1500123001 15 Corn, field, starch-babyfood 0.000200 1.000 0.050 FHE

1500124000 15 Corn, field, syrup 0.000200 1.000 0.050 FHE

1500124001 15 Corn, field, syrup-babyfood 0.000200 1.000 0.050 FHE

1500125000 15 Corn, field, oil 0.000200 1.000 0.050 FHE

1500125001 15 Corn, field, oil-babyfood 0.000200 1.000 0.050 FHE

1500126000 15 Corn, pop 0.000200 1.000 0.050 FHE

1500127000 15 Corn, sweet 0.006000 1.000 0.450 FT MRI

 Full comment: FT MRID 49071008

1500127001 15 Corn, sweet-babyfood 0.006000 1.000 0.450 FT MRI

 Full comment: FT MRID 49071008

1500226000 15 Millet, grain 0.000200 1.000 0.050 FHE

1500231000 15 Oat, bran 0.000200 1.000 0.050 FHE

1500232000 15 Oat, flour 0.000200 1.000 0.050 FHE

1500232001 15 Oat, flour-babyfood 0.000200 1.000 0.050 FHE

1500233000 15 Oat, groats/rolled oats 0.000200 1.000 0.050 FHE

1500233001 15 Oat, groats/rolled oats-babyfood 0.000200 1.000 0.050 FHE

1500323000 15 Rice, white 0.000200 1.000 0.050 FHE

1500323001 15 Rice, white-babyfood 0.000200 1.000 0.050 FHE

1500324000 15 Rice, brown 0.000200 1.000 0.050 FHE

1500324001 15 Rice, brown-babyfood 0.000200 1.000 0.050 FHE

1500325000 15 Rice, flour 0.000200 1.000 0.050 FHE

1500325001 15 Rice, flour-babyfood 0.000200 1.000 0.050 FHE

1500326000 15 Rice, bran 0.000200 1.000 0.050 FHE

1500326001 15 Rice, bran-babyfood 0.000200 1.000 0.050 FHE

1500328000 15 Rye, grain 0.000200 1.000 0.050 FHE
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 46 of 60

1500329000 15 Rye, flour 0.000200 1.000 0.050 FHE

1500344000 15 Sorghum, grain 0.000200 1.000 0.050 FHE

1500345000 15 Sorghum, syrup 0.000200 1.000 0.050 FHE

1500381000 15 Triticale, flour 0.000200 1.000 0.050 FHE

1500381001 15 Triticale, flour-babyfood 0.000200 1.000 0.050 FHE

1500401000 15 Wheat, grain 0.000200 1.000 0.050 FHE

1500401001 15 Wheat, grain-babyfood 0.000200 1.000 0.050 FHE

1500402000 15 Wheat, flour 0.000200 1.000 0.050 FHE

1500402001 15 Wheat, flour-babyfood 0.000200 1.000 0.050 FHE

1500403000 15 Wheat, germ 0.000200 1.000 0.050 FHE

1500404000 15 Wheat, bran 0.000200 1.000 0.050 FHE

1500405000 15 Wild rice 0.000200 1.000 0.050 FHE

1800002000 18 Alfalfa, seed 0.000200 1.000 0.050 FHE

1901028000 19A Basil, fresh leaves 0.008000 1.000 1.000 herb s

 Full comment: herb subgroup except chives

1901028001 19A Basil, fresh leaves-babyfood 0.008000 1.000 1.000 

1901029000 19A Basil, dried leaves 0.019000 1.000 1.000 

1901029001 19A Basil, dried leaves-babyfood 0.019000 1.000 1.000 

1901102500 19A Chive, dried leaves 0.004100 2.900 1.000 D38079

 Full comment: D380795, MRID 48135002

1901118000 19A Cilantro, leaves 0.008000 1.000 1.000 herb s

 Full comment: herb subgroup except chives

1901118001 19A Cilantro, leaves-babyfood 0.008000 1.000 1.000 

1901144000 19A Dillweed 0.008000 1.000 1.000 herb s

 Full comment: herb subgroup except chives

1901184000 19A Herbs, other 0.008000 1.000 1.000 herb s

 Full comment: herb subgroup except chives

1901184001 19A Herbs, other-babyfood 0.008000 1.000 1.000 

1901202000 19A Lemongrass 0.008000 1.000 1.000 herb s

 Full comment: herb subgroup except chives

1901220000 19A Marjoram 0.008000 1.000 1.000 herb s

 Full comment: herb subgroup except chives

1901220001 19A Marjoram-babyfood 0.008000 1.000 1.000 

1901249000 19A Parsley, dried leaves 0.019000 1.000 1.000 herb s

 Full comment: herb subgroup except chives

1901249001 19A Parsley, dried leaves-babyfood 0.019000 1.000 1.000 

1901334000 19A Savory 0.008000 1.000 1.000 herb s

 Full comment: herb subgroup except chives

1902105000 19B Cinnamon 0.000200 1.000 0.050 FHE

1902105001 19B Cinnamon-babyfood 0.000200 1.000 0.050 FHE

1902119000 19B Coriander, seed 0.000200 1.000 0.050 FHE

1902119001 19B Coriander, seed-babyfood 0.000200 1.000 0.050 FHE

1902143000 19B Dill, seed 0.000200 1.000 0.050 FHE

1902274000 19B Pepper, black and white 0.000200 1.000 0.050 FHE

1902274001 19B Pepper, black and white-babyfood 0.000200 1.000 0.050 FHE

1902354000 19B Spices, other 0.000200 1.000 0.050 FHE

1902354001 19B Spices, other-babyfood 0.000200 1.000 0.050 FHE

2001163000 20A Flax seed, oil 0.000200 1.000 0.050 FHE

2001319000 20A Rapeseed, oil 0.000200 1.000 0.050 FHE

2001319001 20A Rapeseed, oil-babyfood 0.000200 1.000 0.050 FHE

2001336000 20A Sesame, seed 0.000200 1.000 0.050 FHE

2001336001 20A Sesame, seed-babyfood 0.000200 1.000 0.050 FHE

2001337000 20A Sesame, oil 0.000200 1.000 0.050 FHE

2001337001 20A Sesame, oil-babyfood 0.000200 1.000 0.050 FHE

2002330000 20B Safflower, oil 0.000200 1.000 0.050 FHE

2002330001 20B Safflower, oil-babyfood 0.000200 1.000 0.050 FHE

2002364000 20B Sunflower, seed 0.000200 1.000 0.050 FHE

2002365000 20B Sunflower, oil 0.000200 1.000 0.050 FHE

2002365001 20B Sunflower, oil-babyfood 0.000200 1.000 0.050 FHE

2003114001 20C Coconut, oil-babyfood 0.000200 1.000 0.050 FHE

2003128000 20C Cottonseed, oil 0.007000 1.000 0.200 

2003128001 20C Cottonseed, oil-babyfood 0.007000 1.000 0.200 

2100228000 21 Mushroom 0.000200 1.000 0.050 FHE

3100044000 31 Beef, meat 0.008400 1.000 0.450 

3100044001 31 Beef, meat-babyfood 0.008400 1.000 0.450 
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 47 of 60

3100045000 31 Beef, meat, dried 0.008400 1.920 0.450 

3100046000 31 Beef, meat byproducts 0.076000 1.000 0.450 

3100046001 31 Beef, meat byproducts-babyfood 0.076000 1.000 0.450 

3100047000 31 Beef, fat 0.038000 1.000 0.450 

3100047001 31 Beef, fat-babyfood 0.038000 1.000 0.450 

3100048000 31 Beef, kidney 0.026000 1.000 0.450 

3100049000 31 Beef, liver 0.076000 1.000 0.450 

3100049001 31 Beef, liver-babyfood 0.076000 1.000 0.450 

3200169000 32 Goat, meat 0.002700 1.000 0.450 

3200170000 32 Goat, meat byproducts 0.011000 1.000 0.450 

3200171000 32 Goat, fat 0.008800 1.000 0.450 

3200172000 32 Goat, kidney 0.002700 1.000 0.450 

3200173000 32 Goat, liver 0.011000 1.000 0.450 

3300189000 33 Horse, meat 0.002400 1.000 0.450 

3400290000 34 Pork, meat 0.020000 1.000 0.050 FHE

3400290001 34 Pork, meat-babyfood 0.020000 1.000 0.050 FHE

3400291000 34 Pork, skin 0.020000 1.000 0.050 FHE

3400292000 34 Pork, meat byproducts 0.020000 1.000 0.050 FHE

3400292001 34 Pork, meat byproducts-babyfood 0.020000 1.000 0.050 FHE

3400293000 34 Pork, fat 0.010000 1.000 0.050 FHE

3400293001 34 Pork, fat-babyfood 0.010000 1.000 0.050 FHE

3400294000 34 Pork, kidney 0.020000 1.000 0.050 FHE

3400295000 34 Pork, liver 0.020000 1.000 0.050 FHE

3500339000 35 Sheep, meat 0.002400 1.000 0.450 

3500339001 35 Sheep, meat-babyfood 0.002400 1.000 0.450 

3500340000 35 Sheep, meat byproducts 0.024000 1.000 0.450 

3500341000 35 Sheep, fat 0.016800 1.000 0.450 

3500341001 35 Sheep, fat-babyfood 0.016800 1.000 0.450 

3500342000 35 Sheep, kidney 0.006000 1.000 0.450 

3500343000 35 Sheep, liver 0.024000 1.000 0.450 

3600222000 36 Milk, fat 0.011000 1.000 0.450 

3600222001 36 Milk, fat-baby food/infant formu 0.011000 1.000 0.450 

3600223000 36 Milk, nonfat solids 0.011000 1.000 0.450 

3600223001 36 Milk, nonfat solids-baby food/in 0.011000 1.000 0.450 

3600224000 36 Milk, water 0.011000 1.000 0.450 

3600224001 36 Milk, water-babyfood/infant form 0.011000 1.000 0.450 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.011000 1.000 0.450 

3800221000 38 Meat, game 0.000200 1.000 0.050 FHE

3900312000 39 Rabbit, meat 0.000200 1.000 0.050 FHE

4000093000 40 Chicken, meat 0.020000 1.000 0.050 FHE

4000093001 40 Chicken, meat-babyfood 0.020000 1.000 0.050 FHE

4000094000 40 Chicken, liver 0.020000 1.000 0.050 FHE

4000095000 40 Chicken, meat byproducts 0.020000 1.000 0.050 FHE

4000095001 40 Chicken, meat byproducts-babyfoo 0.020000 1.000 0.050 FHE

4000096000 40 Chicken, fat 0.010000 1.000 0.050 FHE

4000096001 40 Chicken, fat-babyfood 0.010000 1.000 0.050 FHE

4000097000 40 Chicken, skin 0.020000 1.000 0.050 FHE

4000097001 40 Chicken, skin-babyfood 0.020000 1.000 0.050 FHE

5000382000 50 Turkey, meat 0.020000 1.000 0.050 FHE

5000382001 50 Turkey, meat-babyfood 0.020000 1.000 0.050 FHE

5000383000 50 Turkey, liver 0.020000 1.000 0.050 FHE

5000383001 50 Turkey, liver-babyfood 0.020000 1.000 0.050 FHE

5000384000 50 Turkey, meat byproducts 0.020000 1.000 0.050 FHE

5000384001 50 Turkey, meat byproducts-babyfood 0.020000 1.000 0.050 FHE

5000385000 50 Turkey, fat 0.010000 1.000 0.050 FHE

5000385001 50 Turkey, fat-babyfood 0.020000 1.000 0.050 FHE

5000386000 50 Turkey, skin 0.020000 1.000 0.050 FHE

5000386001 50 Turkey, skin-babyfood 0.020000 1.000 0.050 FHE

6000301000 60 Poultry, other, meat 0.001000 1.000 0.200 FHE

6000302000 60 Poultry, other, liver 0.000500 1.000 0.200 FHE

6000303000 60 Poultry, other, meat byproducts 0.005000 1.000 0.200 FHE

6000304000 60 Poultry, other, fat 0.005000 1.000 0.050 FHE

6000305000 60 Poultry, other, skin 0.005000 1.000 0.200 FHE

7000145000 70 Egg, whole 0.020000 1.000 0.050 FHE

7000145001 70 Egg, whole-babyfood 0.020000 1.000 0.050 FHE
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Page 48 of 60

7000146000 70 Egg, white 0.020000 1.000 0.050 FHE

7000146001 70 Egg, white (solids)-babyfood 0.020000 1.000 0.050 FHE

7000147000 70 Egg, yolk 0.020000 1.000 0.050 FHE

7000147001 70 Egg, yolk-babyfood 0.020000 1.000 0.050 FHE

8000157000 80 Fish-freshwater finfish 0.000200 1.000 0.050 FHE

8000158000 80 Fish-freshwater finfish, farm ra 0.000200 1.000 0.050 FHE

8000159000 80 Fish-saltwater finfish, tuna 0.000200 1.000 0.050 FHE

8000160000 80 Fish-saltwater finfish, other 0.000200 1.000 0.050 FHE

8000161000 80 Fish-shellfish, crustacean 0.000200 1.000 0.050 FHE

8000162000 80 Fish-shellfish, mollusc 0.000200 1.000 0.050 FHE

8601000000 86A Water, direct, all sources 0.000300 1.000 1.000 

8601100000 86A Water, direct, tap 0.000000 1.000 1.000 

8601200000 86A Water, direct, bottled 0.000000 1.000 1.000 

8601300000 86A Water, direct, other 0.000000 1.000 1.000 

8601400000 86A Water, direct, source-NS 0.000000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.000300 1.000 1.000 

8602100000 86B Water, indirect, tap 0.000000 1.000 1.000 

8602200000 86B Water, indirect, bottled 0.000000 1.000 1.000 

8602300000 86B Water, indirect, other 0.000000 1.000 1.000 

8602400000 86B Water, indirect, source-NS 0.000000 1.000 1.000 

9500000500 O Acai berry 0.000200 1.000 1.000 FHE

9500001000 O Acerola 0.004300 1.000 1.000 D42400

 Full comment: D424008

9500001500 O Agave 0.000200 1.000 0.050 FHE

9500006000 O Amaranth, grain 0.000200 1.000 0.050 FHE

9500016000 O Artichoke, globe 0.000200 1.000 0.050 FHE

9500019000 O Asparagus 0.000200 1.000 0.050 FHE

9500019500 O Atemoya 0.000200 1.000 0.050 FHE

9500020000 O Avocado 0.004700 1.000 0.350 

9500022000 O Bamboo, shoots 0.000200 1.000 0.050 FHE

9500023000 O Banana 0.000200 1.000 0.050 FHE

9500023001 O Banana-babyfood 0.000200 1.000 0.050 FHE

9500024000 O Banana, dried 0.000200 1.000 0.050 FHE

9500024001 O Banana, dried-babyfood 0.000200 1.000 0.050 FHE

9500054000 O Belgium endive 0.000200 1.000 0.050 FHE

9500060000 O Breadfruit 0.000200 1.000 0.050 FHE

9500073000 O Cactus 0.000200 1.000 0.050 FHE

9500074000 O Canistel 0.000200 1.000 0.050 FHE

9500077000 O Carob 0.000200 1.000 0.050 FHE

9500089000 O Cherimoya 0.000200 1.000 0.050 FHE

9500109000 O Cocoa bean, chocolate 0.000200 1.000 0.050 FHE

9500110000 O Cocoa bean, powder 0.000200 1.000 0.050 FHE

9500111000 O Coconut, meat 0.000200 1.000 0.050 FHE

9500111001 O Coconut, meat-babyfood 0.000200 1.000 0.050 FHE

9500112000 O Coconut, dried 0.000200 1.000 0.050 FHE

9500113000 O Coconut, milk 0.000200 1.000 0.050 FHE

9500114000 O Coconut, oil 0.000200 1.000 0.050 FHE

9500115000 O Coffee, roasted bean 0.000200 1.000 0.050 FHE

9500116000 O Coffee, instant 0.000200 1.000 0.050 FHE

9500141000 O Date 0.000200 1.000 0.050 FHE

9500151000 O Feijoa 0.004300 1.000 1.000 D42400

 Full comment: D424008

9500153000 O Fig 0.000200 1.000 0.050 FHE

9500154000 O Fig, dried 0.000200 1.000 0.050 FHE

9500177000 O Grape, leaves 0.002300 1.000 0.150 FT

9500178000 O Grape, raisin 0.002300 0.750 0.150 FT

9500183000 O Guava 0.004300 1.000 1.000 D42400

 Full comment: D424008, MRID 49455903

9500183001 O Guava-babyfood 0.004300 1.000 1.000 D42400

 Full comment: D424008, MRID 49455903

9500186000 O Honey 0.000200 1.000 0.050 FHE

9500186001 O Honey-babyfood 0.000200 1.000 0.050 FHE

9500188000 O Hop 0.051000 1.000 1.000 

9500193000 O Jackfruit 0.000200 1.000 0.050 FHE

9500209000 O Longan 0.002400 1.000 1.000 D42400
Abamectin Dietary Exposure Assessment D424009, D421348

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Page 49 of 60

 Full comment: D424008

9500211000 O Lychee 0.002400 1.000 1.000 D42400

 Full comment: D424008, MRID 49455905

9500212000 O Lychee, dried 0.002400 1.850 1.000 D42400

 Full comment: D424008, MRID 49455905

9500214000 O Mamey apple 0.000200 1.000 0.050 FHE

9500215000 O Mango 0.000200 1.000 0.050 FHE

9500215001 O Mango-babyfood 0.000200 1.000 0.050 FHE

9500216000 O Mango, dried 0.000200 1.000 0.050 FHE

9500217000 O Mango, juice 0.000200 1.000 0.050 FHE

9500217001 O Mango, juice-babyfood 0.000200 1.000 0.050 FHE

9500218000 O Maple, sugar 0.000200 1.000 0.050 FHE

9500219000 O Maple syrup 0.000200 1.000 0.050 FHE

9500235000 O Olive 0.000200 1.000 0.050 FHE

9500236000 O Olive, oil 0.000200 1.000 0.050 FHE

9500243000 O Palm heart, leaves 0.000200 1.000 0.050 FHE

9500244000 O Palm, oil 0.000200 1.000 0.050 FHE

9500244001 O Palm, oil-babyfood 0.000200 1.000 0.050 FHE

9500245000 O Papaya 0.086300 1.000 1.000 D42400

 Full comment: D424008, MRID 49455906

9500245001 O Papaya-babyfood 0.086300 1.000 1.000 

9500246000 O Papaya, dried 0.086300 1.800 1.000 Blende

 Full comment: Blended

9500247000 O Papaya, juice 0.086300 1.500 1.000 

9500252000 O Passionfruit 0.004300 1.000 1.000 D42400

 Full comment: D424008

9500252001 O Passionfruit-babyfood 0.004300 1.000 1.000 

9500253000 O Passionfruit, juice 0.004300 1.000 1.000 

9500253001 O Passionfruit, juice-babyfood 0.004300 1.000 1.000 

9500254000 O Pawpaw 0.000200 1.000 0.050 FHE

9500263000 O Peanut 0.000200 1.000 0.050 FHE

9500264000 O Peanut, butter 0.000200 1.000 0.050 FHE

9500265000 O Peanut, oil 0.000200 1.000 0.050 FHE

9500275000 O Peppermint 0.047000 1.000 1.000 

9500276000 O Peppermint, oil 0.047000 1.000 1.000 

9500277000 O Persimmon 0.000200 1.000 0.050 FHE

9500279000 O Pineapple 0.004000 1.000 1.000 D42400

 Full comment: D424008

9500279001 O Pineapple-babyfood 0.004000 1.000 1.000 

9500280000 O Pineapple, dried 0.004000 5.000 1.000 

9500281000 O Pineapple, juice 0.004000 1.700 1.000 

9500281001 O Pineapple, juice-babyfood 0.004000 1.700 1.000 

9500283000 O Plantain 0.000200 1.000 0.050 FHE

9500284000 O Plantain, dried 0.000200 1.000 0.050 FHE

9500289000 O Pomegranate 0.000200 1.000 0.050 FHE

9500306000 O Psyllium, seed 0.000200 1.000 0.050 FHE

9500311000 O Quinoa, grain 0.000200 1.000 0.050 FHE

9500333000 O Sapote, Mamey 0.086300 1.000 1.000 D42400

 Full comment: D424008

9500335000 O Seaweed 0.000200 1.000 0.050 FHE

9500335001 O Seaweed-babyfood 0.000200 1.000 0.050 FHE

9500346000 O Soursop 0.000200 1.000 0.050 FHE

9500351000 O Spanish lime 0.002400 1.000 1.000 D42400

 Full comment: D424008

9500352000 O Spearmint 0.047000 1.000 1.000 

9500353000 O Spearmint, oil 0.047000 1.000 1.000 

9500358000 O Starfruit 0.004300 1.000 1.000 D42400

 Full comment: D424008

9500361000 O Sugar apple 0.000200 1.000 0.050 FHE

9500362000 O Sugarcane, sugar 0.000200 1.000 0.050 FHE

9500362001 O Sugarcane, sugar-babyfood 0.000200 1.000 0.050 FHE

9500363000 O Sugarcane, molasses 0.000200 1.000 0.050 FHE

9500363001 O Sugarcane, molasses-babyfood 0.000200 1.000 0.050 FHE

9500368000 O Tamarind 0.000200 1.000 0.050 FHE

9500372000 O Tea, dried 0.000200 1.000 0.050 FHE
Abamectin Dietary Exposure Assessment D424009, D421348

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Page 50 of 60

9500373000 O Tea, instant 0.000200 1.000 0.050 FHE

9500373500 O Teff, flour 0.000200 1.000 0.050 FHE

9500390000 O Vinegar 0.000200 1.000 0.050 FHE

9500397000 O Water chestnut 0.000200 1.000 0.050 FHE

9500398000 O Watercress 0.000200 1.000 0.050 FHE
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Page 51 of 60

Attachment 7: Chronic Food plus Water Results File

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for AVERMECTIN NHANES 2003-2008 2-day

Residue file name: C:\Users\KRURY\Documents\My Work Files\Abamectin\Dietary Files\Abamectin 

chronic PRIA 3 29 16.R08

 Adjustment factor #2 used.

Analysis Date 03-29-2016/13:13:10 Residue file dated: 03-29-2016/09:11:57

Reference dose (RfD, Chronic) = .0025 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.000056 2.2%

Hispanic 0.000067 2.7%

Non-Hisp-White 0.000055 2.2%

Non-Hisp-Black 0.000047 1.9%

Non-Hisp-Other 0.000060 2.4%

Nursing Infants 0.000039 1.6%

Non-Nursing Infants 0.000122 4.9%

Female 13+ PREG 0.000047 1.9%

Children 1-6 0.000193 7.7%

Children 7-12 0.000083 3.3%

Male 13-19 0.000049 2.0%

Female 13-19/NP 0.000041 1.6%

Male 20+ 0.000038 1.5%

Female 20+/NP 0.000037 1.5%

Seniors 55+ 0.000037 1.5%

All Infants 0.000096 3.9%

Female 13-50 0.000038 1.5%

Children 1-2 0.000268 10.7%

Children 3-5 0.000160 6.4%

Children 6-12 0.000090 3.6%

Youth 13-19 0.000045 1.8%

Adults 20-49 0.000038 1.5%

Adults 50-99 0.000037 1.5%

Female 13-49 0.000038 1.5%

-------------------------------------------------------------------------------
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 52 of 60

Attachment 8: Acute Water Only Residue Input File

Filename: C:\Users\ndodd\Documents\DEEM Version 3.16\Abamectin Soybean 2014\AVERMECTIN ACUTE Water 

Only 102714.R08

Chemical: Avermectin

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 10-27-2014/15:33:59 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

 # Code 

----- ---- ------------ -------- -------- -------

 1 6 Aba_MSsoyb_MSsoybeanSTD_Reservoir_Parent_DEEM.rdf

 EPA Crop Commodity Name Def Res Adj.Factors RDLComment

 Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

8601000000 86A Water, direct, all sources 0.000760 1.000 1.000 1 

8602000000 86B Water, indirect, all sources 0.000760 1.000 1.000 1 

Attachment 9: Acute Water Only Results File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for AVERMECTIN NHANES 2003-2008 2-Day

Residue file: AVERMECTIN ACUTE Water Only 102714.R08

 Adjustment factor #2 used.

Analysis Date: 10-27-2014/15:43:24 Residue file dated: 10-27-2014/15:33:59

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population: 0.000009 0.35 0.000015 0.62 0.000031 1.24 

All Infants: 0.000027 1.07 0.000044 1.74 0.000077 3.08 

Children 1-2: 0.000013 0.52 0.000023 0.93 0.000049 1.94 

Children 3-5: 0.000011 0.43 0.000018 0.73 0.000035 1.41 

Children 6-12: 0.000008 0.32 0.000014 0.57 0.000027 1.06 

Youth 13-19: 0.000007 0.28 0.000013 0.50 0.000023 0.93 

Adults 20-49: 0.000008 0.34 0.000014 0.57 0.000025 1.02 

Adults 50-99: 0.000008 0.31 0.000013 0.52 0.000023 0.93 

Female 13-49: 0.000009 0.34 0.000014 0.57 0.000026 1.02 
Abamectin Dietary Exposure Assessment D424009, D421348

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Attachment 10: Chronic Water Only Residue Input File

Filename: C:\Users\ndodd\Documents\DEEM Version 3.16\Abamectin Soybean 2014\AVERMECTIN CHRONIC 

Water Only 102714.R08

Chemical: Avermectin

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 09-17-2014/15:17:15 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

8601000000 86A Water, direct, all sources 0.000300 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.000300 1.000 1.000 

Attachment 11: Chronic Water Only Results File

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for AVERMECTIN NHANES 2003-2008 2-day

Residue file name: C:\Users\ndodd\Documents\DEEM Version 3.16\Abamectin Soybean 2014\AVERMECTIN 

CHRONIC Water Only 102714.R08

 Adjustment factor #2 used.

Analysis Date 10-27-2014/14:21:54 Residue file dated: 09-17-2014/15:17:15

Reference dose (RfD, Chronic) = .0025 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.000006 0.3%

Hispanic 0.000006 0.2%

Non-Hisp-White 0.000006 0.3%

Non-Hisp-Black 0.000005 0.2%

Non-Hisp-Other 0.000007 0.3%

Nursing Infants 0.000006 0.2%

Non-Nursing Infants 0.000021 0.8%

Female 13+ PREG 0.000006 0.2%

Children 1-6 0.000008 0.3%

Children 7-12 0.000005 0.2%

Male 13-19 0.000004 0.2%

Female 13-19/NP 0.000005 0.2%

Male 20+ 0.000006 0.2%

Female 20+/NP 0.000007 0.3%

Seniors 55+ 0.000006 0.2%

All Infants 0.000016 0.6%

Female 13-50 0.000006 0.3%

Children 1-2 0.000009 0.4%

Children 3-5 0.000008 0.3%

Children 6-12 0.000006 0.2%

Youth 13-19 0.000005 0.2%

Adults 20-49 0.000006 0.3%

Adults 50-99 0.000006 0.2%

Female 13-49 0.000006 0.2%

-------------------------------------------------------------------------------
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 54 of 60

Attachment 12: BEAD Percent Crop Treated Data

Table 11. Screening Level Estimates of Agricultural Uses of Abamectin 

Crop

Percent Crop Treated

July 1, 20151 August 27, 20152

Average Maximum Average Maximum

Almonds 70 80 --

Apples 10 30 -- --

Apricots 15 30 -- --

Avocados 35 60 -- --

Beans, dry <2.5 <2.5

Caneberries -- -- 56 68

Cantaloupes 25 45 -- --

Celery 45 70 -- --

Cherries 5 20 -- --

Cotton 20 30 -- --

Cucumbers 5 10 -- --

Grapefruit 70 90 -- --

Grapes 15 35 -- --

Hazelnuts <2.5 <2.5 -- --

Honeydew 20 35 -- --

Lemons 40 55 -- --

Lettuce 20 45 -- --

Nectarines 20 20 -- --

Onions <2.5 10

Oranges 40 70 -- --

Peaches 10 25 -- --

Pears 70 85 -- --

Pecans <1 <2.5 -- --

Peppers 15 30 -- --

Pistachios <2.5 <2.5 -- --

Plums/Prunes 10 35

Potatoes 5 20 -- --

Pumpkins 5 10 -- --

Soybean -- -- 8 11

Spinach 25 45 -- --

Squash 5 15 -- --

Strawberries 30 45 -- --

Sweet corn -- -- 45 57

Tangerines 35 55 -- --

Tomatoes 10 25 -- --

Walnuts 25 55 -- --

Watermelons 5 15 -- -- 1 Memo with no DP number, Jihad Alsadek, 7/1/15. SLUA data sources include: USDA-NASS

and Private Pesticide Market Research. 2 D428074, Don Atwood, Ph.D., 8/27/15. The data source was proprietary data from 2011-2013.
Abamectin Dietary Exposure Assessment D424009, D421348

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Attachment 13. Calculation of Livestock Anticipated Residues

13.1. Livestock Dietary Burden Estimations

A summary of all of the livestock feeds considered in a more balanced diet (MDB) is presented in 

Table 13.1.1.

Table 13.1.1. Feeds Considered in More Balanced Diet – Acute Assessment

Crop Commodity Type Input %DM Max 

%Diet

% Diet 

Used

Beef Cattle

Cotton Hulls R 0.006 Median 90 10 10

Citrus Pulp, dried R 0.02 Median 91 10 0

Cotton Gin byproducts R 0.018 Median 90 5 0

Pineapple Process residue R 0.016 Median 25 10 0

Grain Aspirated grain fractions CC 0.4 Median 85 5 5

Potato Culls CC 0.0027 HR 20 30 0

Potato Process Waste CC 0.0027 Median 12 30 0

Cotton Meal PC 0.006 Median 89 5 5

Soybean Seed PC 0.006 Median 89 5 0

Dairy Cattle

Corn, 

sweet Forage R 0.102 HR 48 45 45

Almond Hulls R 0.039 Median 90 10 0

Citrus Pulp, dried R 0.02 Median 91 10 0

Pineapple Process residue R 0.016 Median 25 10 0

Corn, 

sweet Cannery waste CC 0.063 Median 30 10 10

Apples Pomace, wet CC 0.02 Median 40 10 0

Potato Culls CC 0.0027 HR 20 10 0

Potato Process Waste CC 0.0027 Median 12 10 0

Cotton Undelinted seed PC 0.006 Median 88 10 10

Cotton Meal PC 0.006 Median 89 10 0

Soybean Seed PC 0.006 Median 89 10 0

Poultry

Cotton Meal PC 0.006 Median 89 20 20

Soybean Seed PC 0.006 Median 89 20 5

Swine

Cotton Meal PC 0.006 Median 89 15 15

Soybean Seed PC 0.006 Median 89 15 0

A summary of the livestock feed items that results in the highest dietary burden using the guidance 

for a more balanced diet is presented in table 13.1.2.
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Table 13.1.2. More Balanced Diet (MBD) Used for Dietary Burden Estimation for Tolerance Estimates and 

Anticipated Residues

Crop Commodity Type Residue %DM %Diet Dietary Contribution, 

ppm input ppm

Beef Cattle

Cotton Hulls R 0.006 Median 90 10 0.0007

Grain Aspirated grain fractions CC 0.4 Tolerance 85 5 0.02

Cotton Meal PC 0.006 Median 89 5 0.0003

Untreated feed NA NA NA NA NA 80 0

Total NA NA NA NA NA 100 0.02

Dairy Cattle

Corn, sweet Forage R 0.102 HR 48 45 0.10

Corn, sweet Cannery waste CC 0.063 Median 30 10 0.02

Cotton Undelinted seed PC 0.006 Median 88 10 0.0007

Untreated feed NA NA NA NA NA 35 0

Total NA NA NA NA NA 100 0.12

Poultry

Cotton Meal PC 0.006 Median 89 20 0.001

Soybean Seed PC 0.006 Median 89 5 0.0003

Untreated feed NA NA NA NA NA 75 0

Total NA NA NA NA NA 100 0.002

Swine

Cotton Meal PC 0.006 Median 89 15 0.0009

Untreated feed NA NA NA NA NA 85 0

Total NA NA NA NA NA 100 0.0009

13.2 Livestock Feeding Studies – Determination of Tissue to Feed Ratios

RCB #1568, L. Cheng, 2/11/87

Feeding studies have been submitted only for cattle at feeding levels of 0.01, 0.03, and 0.1 ppm. 

The results of the residue analyses and tissue to feed ratios are presented in Table 13.4.1. The 

tissue to feed ratios from the dose level closest to the dietary burden was used in the calculation. 

Therefore, the 0.1 ratio was used for estimated residues in tissues and milk

Table 13.2. Summary of Livestock Feeding Studies with Abamectin.

Commodity Feeding Level, ppm Residue in Tissue/Milk, ppm1 Tissue-to-Feed Ratio

Milk

0.010 ND2 --

0.030 0.001 0.033

0.100 0.004 0.040

Muscle 

(cattle)

0.010 0.002 0.20

0.030 0.002 0.067

0.100 0.002 0.02

Fat (cattle)2

0.010 0.002 0.20

0.030 0.006 0.20

0.100 0.014 0.14

Liver (cattle) 0.010 0.004 0.40

0.030 0.008 0.27
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Page 57 of 60

Table 13.2. Summary of Livestock Feeding Studies with Abamectin.

Commodity Feeding Level, ppm Residue in Tissue/Milk, ppm1 Tissue-to-Feed Ratio

0.100 0.020 0.2

Kidney 

(cattle)

0.010 0.002 0.2

0.030 0.002 0.067

0.100 0.005 0.05 1

maximum residue 

2 ND = not detectable.

13.3. Estimation of Residues in Livestock Commodities – Cattle, Goat, Sheep, Horses

Residues of abamectin can be expected in cattle commodities from consumption of treated feed as 

well as dermal exposure from ear tags. There are no ear tag uses registered for the remaining types 

of livestock. Upper bound residues are assumed from a diet based on the maximum reasonable 

dietary burden used to calculate the tolerances. The secondary residues from cattle consuming 

treated feed were added to the upper bound residues from the ear tag for the total abamectin 

residues in each edible livestock commodity. This is considered to be a conservative estimate 

since upper bound residues from crop field trials were used assuming maximum dietary burden; 

actual residues in treated feed are likely to be lower.

The dietary burden estimates were highest for dairy cattle, so the secondary residues will be based 

on the burden of 0.12 ppm. A summary of the estimated residues is presented in Table 13.3. For 

acute assessments, the percent crop treated is based on the maximum percent crop treated of any of 

the feed items included in the diet, sweet corn at 57%. For the chronic assessments, the percent 

crop treated is also based on sweet corn at 45%.

Table 13.3 Estimated Residues in Livestock Commodities 

Commodity Tissue to 

Feed Ratio

Dietary 

Burden

(ppm)

Estimated 

Residue from 

Livestock Feed

(ppm)

Estimated 

Residue from 

Cattle Ear Tag 

Use1

(ppm)

Total 

Estimated 

Residue

(ppm)

Cattle, fat 0.14 0.12 0.0168 0.018 0.0384 0.0036

Cattle, meat 0.02 0.12 0.0024 0.005 0.0084 0.001

Cattle, meat byproducts 

(Liver) 0.2 0.12 0.024 0.043 0.0756 0.0086

Cattle, meat byproducts; 

(Kidney) 0.05 0.12 0.006 0.017 0.0264 0.0034

Milk 0.04 0.12 0.0048 0.0046 0.011

Goat, fat 0.12 0.0088 -- 0.0088

Goat, meat 0.12 0.0027 -- 0.0027

Goat, meat byproducts;(Liver) 0.12 0.011 -- 0.011

Goat, meat byproducts 

(Kidney) 0.0027 -- 0.0027

Sheep, horse, meat 0.12 0.0024 -- 0.0024
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 58 of 60

Table 13.3 Estimated Residues in Livestock Commodities 

Commodity Tissue to 

Feed Ratio

Dietary 

Burden

(ppm)

Estimated 

Residue from 

Livestock Feed

(ppm)

Estimated 

Residue from 

Cattle Ear Tag 

Use1

(ppm)

Total 

Estimated 

Residue

(ppm)

Sheep, meat byproducts, incl. 

liver 0.12 0.024 -- 0.024

Sheep, fat 0.12 0.0168 -- 0.0168

Sheep, kidney 0.12 0.0060 -- 0.0060

13.4 . Estimation of Residues in Livestock Commodities - Poultry and Swine

Tolerances are established on Poultry, Hog Meat, Meat by-products at 0.02 ppm and Hog Fat at 

0.01 ppm based on the food handling establishment (FHE) use. As noted in table 13.1.2, the 

dietary burden for poultry and hogs are very low, 2 ppb or less. The secondary residues from 

poultry and hogs consuming treated feed will be considerably lower than the currently established 

tolerance. Therefore, the tolerance value for these commodities will be used in the acute and 

chronic dietary assessments. Although the Agency typically does not include FHE uses in acute 

assessments, the tolerance value will be included in the acute assessment in consideration of the 

secondary residues. The percent crop treated will be based on the FHE uses, 5%, since these uses 

will result in the highest residues. 
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 59 of 60

Attachment 14: Acute Critical Exposure Contribution Analysis

U.S. EPA

DEEM-FCID Acute Critical 

Exposure Contribution Analysis 

(Ver. 3.16

03-08-

d)

NHANES 2003-2008 2-Day

Residue file = C:\Users\KRURY\Documents\My Work Files\Abamectin\Dietary Files\Abamectin acute Food and 

Water PRIA 3 29 16.R08

Date and time of analysis: 04-12-2016 15:37:32

Daily totals for food and foodform consumption used.

Adjustment factor #2 used.

Minimum exposure contribution = 1%

MC Iterations = 1000 Seed = 10 RNG = MS VB

Exposures divided by body weight

Subpopulations:

 1 Children 1-2

================================================================================

Children 1-2

Low percentile for CEC records: 99.9 Exposure (mg/day) = 0.002197

High percentile for CEC records: 100 Exposure (mg/day) = 0.004147

Number of actual records in this interval: 3132

Critical foods with foodforms for this population (as derived from these records):

 N=number of appearances in all records (including duplicates)

 %=percent of total exposure for all records (including duplicates)

Food FF N 

 

Percent Food Name 

---------- --- ----- ------- -------------

3600224000 110 2661 52.69% Milk

water-Uncooked; Fresh or N/S; 

Cook Meth N/S

9500247000 110 670 26.28% Papaya

juice-Uncooked; Fresh or N/S; 

Cook Meth N/S

9500247000 240 365 5.05% Papaya

juice-Cooked; Canned; 

Cook Meth N/S

3600223000 110 1854 3.98% Milk

nonfat solids-Uncooked; Fresh or 

N/S; Cook Meth N/S

3100049000 210 365 3.66% Beef

liver-Cooked; Fresh or N/S; Cook 

Meth N/S
Abamectin Dietary Exposure Assessment D424009, D421348

PC Code: 122804

Page 60 of 60

3600222000 110 1316 1.04% Milk

fat-Uncooked; Fresh or N/S; Cook 

Meth N/S

1307132000 110 663 0.64%

 

Cranberry

juice-Uncooked; Fresh or N/S; 

Cook Meth N/S