RR Case Name PC Codes CAS #

Diethylene Glycol Monomethyl Ether 042204 111-77-3

TABLE OF CONTENTS PAGE No.

DIETHYLENE GLYCOL MONOMETHYL ETHER..................2

APPENDICES-------------------------------------------------------------------- 7

REGISTRATION REVIEW DOCUMENT

PRODUCT CHEMISTRY, ENVIRONMENTAL FATE AND

ECOLOGICAL EFFECTS SUMMARY FOR DIETHYLENE GLYCOL 

MONOMETHYL ETHER

PCCode: 042204 Case No. 5010

Chemical name Use patterns/use sites

Diethylene Glycol Monomethyl 

Ether

Used in Liquid hydrocarbon fuels, 

an antimicrobial and anti-icing (deicer) control (0.10-0.15 % by 

volume)

Regulatory History:

Table 1: Registered Active Products for Diethylene Glycol Monomethyl Ether

EPA Reg. 

Number

Product Name Formulation 

Type

% Active 

Ingredient

Registrant

224-32 Phillips Fuel

Additive 56 MB

Petroleum 

Distillate

99.7 Phillips 66 Company/ a 

Subsidiary of Phillips 

Petroleum Company

Table 2. Chemical Identity 

Common Name Diethylene Glycol Monomethyl Ether

Chemical Name 2-(2-Methoxyethoxy) ethanol

IUPAC Name 2-(2-Methoxyethoxy)ethanol

Molecular Weight 120.15
Table 2. Chemical Identity 

PC Code 011504

CAS Registry Number 111-77-3

Molecular Formula/Empirical 

Formula

C5H12O3

Registration Review Case No. 5010

Registration Review Case Name Diethylene Glycol Monomethyl Ether

Classification: Organic

Structures: 

CH3 – (O-CH2-CH2)2-OH

Science Findings:

Data are summarized for each discipline in the following sections:

Product Chemistry Summary

Table 3: Physical and Chemical Properties of Diethylene Glycol Monomethyl Ether

Guideline 

No.

Physical and Chemical Properties Value

830.1550 Product identity and composition Refer to Table 2

830.1600 Description of materials used to 

produce the product

Cbi

830.1620 Description of production process Cbi

830.1650 Description of formulation process Cbi

830.1670 Discussion of formation of impurities Cbi

830.1700 Preliminary analysis Cbi

830.1750 Certified limits Cbi

830.1800 Enforcement analytical method Cbi

830.1900 Submittal of samples Cbi

830.6302 Color Transparent:

830.6303 Physical State Liquid

830.6304 Odor Mild: 

830.6313 Stability to sunlight, normal and 

elevated temperature

NA

830.6314 Oxidation/Reduction: Chemical 

Incompatibility

No redox properties

830.6315 Flammability

Flash Point

~ 80 o C

830.6316 Explodability NA

830.6317 Storage Stability Stable

830.6319 Miscibility 100% at 20 o C

830.6320 Corrosion Characteristic Non-corrosive
Guideline 

No.

Physical and Chemical Properties Value

830.6321 Dielectric breakdown voltage NA

830.7000 pH 5-8.5

830.7050 UV/Visible absorption spectra No absorption in UV range;

830.7100 Viscosity 3.9 centipoise

830.7200 Melting Point NA

830.7220 Boiling point 193 o C

830.7300 Density/ Bulk density 1.035 g/cc

830.7370 Dissociation Constants in water NA

830.7520 Particle size NA

830.7550 Octanol/water partition coefficient 

(KOW) (Log Kow )

-1.18 (EPI SUITE)

830.7840 Solubility in water Highly miscible

830-7840 Solubility in organic solvents in g/100 

ml

Highly miscible in alcohol, ether, and acetone

830.7950 Vapor pressure 0.25 mm Hg at 25 o C

Environmental Fate and Transport Data Summary:

Following fate related parameters for DGME are obtained from US EPA’s EPI SUITE 

Program:

1. Vapor Pressure: 0.25 mm Hg at 25 C

2. Log Kow: -1.81 (estimated)

3. Henry Law Constant(HLC): 6.5 x 10-10 atm m3/mol

4. Ready Biodegradability: it is readily biodegradable

5. Under anaerobic conditions: it is not readily biodegradable

6. Half life in air: 4.93 hours (estimated)

7. Koc: 1 L/Kg

8. In Wastewater Treatment Plant: Total removal in sludge: <2%

Environmental Fate and Transport Conclusions:

There are no data generated based on the environmental fate test guidelines series 161 . 

However some important fate parameters are available in literature, some measured, and 

some estimated as listed above. Based on these fate characteristics:

DGME is highly volatile substance and easily transfer into the atmosphere; however, its 

half life in air is short (4.93 hours), and is likely to degrade easily. It is highly water 

soluble, and under aerobic conditions it can undergoes ready biodegradation..

Its Koc is small (~ 1 L/Kg) and it will migrate from surface soil to ground water easily; 

however, it is likely to biodegrade over a period of time.

Estimated log Kow ( -1.81) is negligible, and it is not likely to bioaccumulate in aquatic 

organisms, and there are no eco risk concerns for aquatic organisms through the DGME 

exposure, and for the use pattern at this time.
Environmental Fate and Transport Data Gaps

At this time the Agency does not anticipate requiring additional fate data for the present 

use and use scenario.

Ecological Effects Data Summary:

Table 4 summarizes the eco-effects data.

Table 4

 Ecotoxicity Data

Guideline #/Study 

type

MRID#/ Classification Dosing/Organism 

Information

Results

850.1010: Aquatic 

Invertebrate Acute 

Toxicity

MRID#: 45719201: 

Guideline: Core

Daphnia magna

Purity: 99.9%

48 hour EC50: 

930 mg a.i./L

NOAEC: 930 mg 

a.i./L

850.1075

Fish Acute 

Toxicity

MRID#: 4519202: 

Guideline: Core

Rainbow Trout; 

Purity: 99.9%

96 hr LC50:>960 

mg a.i./L; 

NOAEC: 960 mg 

a.i./L

850.1075: Acute 

Toxicity to 

Estuarine/Marine 

Organisms

MRID#: 43945608 Test substance 

administered at 

5,000 and 10,000 

ppm

Bluegill sunfish

Purity not reported

LC50: 7,500 ppm

0% survival after 

48 hours at 

10,000 ppm

100% survival 

after 96 hours at 

5,000 ppm

850.2100: Avian 

Acute Oral 

Toxicity

MRID# 45325101: 

Guideline: Core

Northern bobwhite

Purity: 99.7%

LD50> 2250 

mg/kg 

(determined by 

visual inspection)

NOAEL: 2250 

mg/kg

Hazard and Risk Conclusions 

Some of these studies are submitted studies, and some were acquired from open 

literature and or ECOTOX database. These studies have not been reviewed and assessed

by the Agency. For the present use, the Agency has not conducted any hazard 

assessment.

However, the available ecotoxicity data categorize technical grade DGME as being 

practically non-toxic to birds and aquatic organisms. The Agency will conduct hazard 

risk assessment based on the data listed in Table 4, and also after review and assessment 

of the algal toxicity study data (850.5400)
Ecotoxicity Data Gaps:

The Agency will require the following ecotoxicity study.

850.5400: Algal Toxicity Study (Tier II)

BIBLIOGRAPHY FOR: PRODUCT CHEMISTRY, ENVIRONMENTAL FATE

AND TRANSPORT, AND ECO-TOXICITY 

1. MRID#: 45719201: Machado, M (2002); Phillips Fuel Additive 56 MB: 

Acute Toxicity to Water Fleas (Daphnia Magna) Under Flow Through 

Conditions; Lab Project #: 13695.6118, unpublished study, submitted by: 

Springborn Smithers Labs, 56 pages

2. MRID# 4519202: Machado, M (2002): Phillips fuel Additives/ 56 MB: Acute 

Toxicity to Rainbow Trout Under Flow Through Conditions; Lab Project#: 

13695.6119; unpublished study prepared by Springborn Smithers Labs, 55 

pages.

3. MRID#: 4394608, Dowson, G, et al (1976): The Acute Toxicity of 47 

Industrial Chemicals to Fresh and Saltwater Fishes: Journal of hazardous 

Materials, 1: pp 308-318

4. MRID#: 45325101: Gallagher et al. (2000), PFA 56 MB: An Acute Oral 

Toxicity Study with Bobwhite ; Lab Project #: 251-110; unpublished study by 

Wild Life International, Ltd, 29 pages.

5. EPI SUITE, Version 4.0