Exhibit 4.1

 



C0000000230 | M   NOVELION THERAPEUTICS INC. Number Shares * * * * 0 * * * * * * * * * * * * *   * 0 * * * * * * * * * * * * * * 0 * * * * * * * * * * * * * * 0 * * * * * * *   * * * * * * * 0 * * * * * 00000000 A BRITISH COLUMBIA BUSINESS CORPORATIONS   ACT COMPANY   **SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIME   N67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20   200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000   THIS CERTIFIES THAT   NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*   THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NSOVEPLIONE*THCERAPIEMUTICSE*INNC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUT   ICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*   zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****S   PECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67   001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200   000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOV   ELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THERAPEUTICS*INC.*zero****SPECIMEN67001K20200000000NOVELION*THE   **067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOV   ELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.   *zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K2020000   IS THE REGISTERED HOLDER OF   20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K*2020*000*0000OVE*LIO*N*TH*ERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THE   0000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTI   CS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K   RAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****   067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVEL   ION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*z   ero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K20200000000NOVELION*THERAPEUTICS*INC.*zero****067001K202000000   SEE REVERSE FOR CERTAIN DEFINITIONS FULLY PAID AND NON-ASSESSABLE COMMON   SHARES WITHOUT PAR VALUE IN THE CAPITAL OF NOVELION THERAPEUTICS INC. in the   Authorized share structure of the above named Company subject to the Articles   of the Company transferable on the Central Securities Register of the Company   by the registered holder in person or by attorney duly authorized in writing   upon surrender of this certificate properly endorsed. This certificate is not   valid unless countersigned by the Transfer Agent and Registrar of the   Company. IN WITNESS WHEREOF the Company has caused this certificate to be   signed on its behalf by the facsimile signatures of its duly authorized   officers, at Vancouver, British Columbia. Dated: Dec 13, 2016 Chief Executive   Officer COUNTERSIGNED AND REGISTERED COMPUTERSHARE INVESTOR SERVICES INC.   (VANCOUVER) (TORONTO) TRANSFER AGENT AND REGISTRAR General Counsel By   Authorized Officer The shares represented by this certificate are   transferable at the offices of Computershare Investor Services Inc. in   Vancouver, BC and Toronto, ON. CSAE_WIP_QLTQ_C02.mtl.pulls/000001/000001/i   ISIN CA67001K2020 CUSIP 67001K202 


    




 









 



The follo\•Jing   abbreviations shall be construed as though the \•rords set forth below   opposite each abbreviation were 'iofitlen Old in full ._...here such   abbreviation appears: TEN COM TEN ENT JTTEN as tenants in common as tenants   by the entireties as joint tenants >.o.;th rights of SUivi·;orship and not   as tenants in common (Name) CUST (Name) UNtF GIFT MIN ACT (State) (Name) as   Custodianfor (Name) under the (Siote) Uniform Gifts to Minors Act   Additionalabbreviations may also be used though not in the above list. For   value received the undersigned hereby sells, assigns and transfers unto   Insert name and address of transferee shares represented by this certificate   and does hereby irrevocably constitute and appoint the attorney of the   undersigned to transfer the said shares on the books of the Company with full   power of substitution in the premises. DATED _ Signature of Shareholder   Signature of Guarantor Signature Guarantee: The signature on this assignment   must correspond with the name as written upon the face of the certificate(s),   in every particular, without alteration or enlargement, or any change   whatsoever and must be guaranteed by a major Canadian Schedule l chartered   bank or a member of an acceptable Medallion Signature Guarantee Program   (STAMP, SEivlP, lvlSP) The Guarantor must affix a stamp bearing the actual   words "Signature Guaranteed". In the USA, signature guarantees must   be done by members of a "lvledallion Signature Guarantee Program"   only. Signature guarantees are not accepted from Treasury Branches, Credit   Unions or Caisses PopuIaires unless they are members of the Stamp Medallion   Program. SECURITY INSTRUCTIONS-INSTRUCTIONS DE SECURITE 1111S IS WA1CRMAI1KCD   PAPLA, DO N01 ACCCPl WITIIOUT NOTIN O Will CRMARK·I IOLI) TO liGHT TO VERIFY   W/\TFRMIIRK. PAPILH f lliGHANI. NE PIIS ACCFPTFR SANS VFRIFIF.A IA PRFSFNCE   DU FILIGRANE. POUICE FAIRE,PLACER A LA LUMIERE. EN_COMP_V2_01