Cyazofamid Dietary Exposure and Risk Assessment DP Number: 371163

PC Code: 085651 

______________________________________________________________________________________

1

 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

 

 

OFFICE OF 

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM 

DATE: March 8, 2010

SUBJECT: Cyazofamid: Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessments for Tolerance Petition and Proposed Section 3 

Amendment Registration for Uses on Brassica (Cole) Leafy Vegetables Crop 

Group 5, Turnip Greens, Spinach, and Hops.

PC Code: 085651 DP Barcode: 371163

Decision No.: 420982 Registration No.: 71512-2 , 71512-3

Petition No.: 9E7615 Regulatory Action: Sec. 3 Registration

Risk Assessment Type: NA Case No.: NA

TXR No.: NA CAS No.: 120116-88-3

MRID No.: 40 CFR: 180.601

REVIEWER: Amelia M. Acierto, Chemist

Risk Assessment Branch 3

Health Effects Division (7509P)

THROUGH:

Mohsen Sahafeyan, Chemist

Thurston Morton, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Stephen Funk, Senior Science Advisor

Risk Assessment Branch III

Health Effects Division (7509P)

TO: Nancy Tsaur, Risk Assessor

Risk Assessment Branch III

Health Effects Division (7509P)

and

Barbara Madden, RM #5

Risk Integration, Minor Use, and Emergency Response Branch

Registration Division (7505P)
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 371163

PC Code: 085651 

______________________________________________________________________________________

2

Executive Summary

Acute (females 13-49 years old only) and chronic dietary (food and drinking water) exposure and 

risk assessments were conducted using the Dietary Exposure Evaluation Model (DEEMFCIDTM), Version 2.03, which uses food consumption data from the U.S. Department of 

Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 

1998. Dietary risk assessments were performed to support a FIFRA Section 3 request to amend 

the registration of the fungicide cyazofamid for use on Brassica (Cole) leafy vegetables crop 

group 5, turnip greens, spinach, and hops.

Acute and chronic dietary (drinking water) risk assessment for cyazofamid have been conducted 

previously for turf and ornamentals (D332427, Susan L. Stanton, 9/14/06). The risk estimate 

considered drinking water exposure only. Subsequent dietary risk assessments were performed 

to support separate FIFRA Section 3 requests on carrots (D381623, A.M.Acierto, 3/5/2008) and 

on fruiting vegetables, okra, and grapes (D357043, Amelia M. Acierto 3/25/09). Dietary risk 

estimates were determined considering exposures from food plus drinking water using the upperbound estimated drinking water concentrations (EDWCs) for cyazofamid in surface water 

sources for turf grass provided by the Environmental Fate and Effects Division (EFED). This 

decision was based on EFED’s determination that the highest use rate per application per season 

is on turf grass as compared with the use rates on various food crops (D342613, Mohammed A. 

Ruhman, 2/21/08 and D356836, Jose L. Melendez, 3/24/09). Additional runs to cover the new 

crops (Brassica (Cole) leafy vegetables crop group 5, turnip greens, spinach, and hops) were 

performed by EFED with the same result that the highest EDWCs of all crops (past and present) 

were obtained for turf and ornamentals (surface waters) and ornamentals (ground water)

(D370673, Jose L. Melendez, 3/1/2010). As in the earlier dietary assessments, HED used the 

highest calculated screening EDWCs for surface water based on the 3

rd modeling scenario: 136 

ppb for the acute analysis and 133 ppb for the chronic analysis. As noted previously, this

approach may significantly overestimate dietary exposure to cyazofamid from drinking water; 

however, since estimated aggregate food and drinking water exposures using this approach are 

well below the acute and chronic levels of concern, additional refinements were not deemed 

necessary. For both the acute and chronic analyses, the drinking water EDWC was incorporated 

directly as a point estimate in the DEEM analysis to assess exposure to cyazofamid from 

drinking water. Drinking water was incorporated directly into the DEEM-FCID into the food 

categories “water, direct, all sources” and water, indirect, all sources.

The acute dietary (food plus drinking water) analysis was performed for females 13-49 years old 

only since an acute endpoint of concern was not identified for the general U.S. population. The 

chronic dietary analyses were performed for the general U.S. population and all the population 

subgroups. HED is concerned when estimated dietary risks exceed 100% of the acute or chronic 

population adjusted dose (aPAD and cPAD). 

 

The acute and chronic analyses assumed that cyazofamid residues are present in all registered 

food commodities at tolerance levels and that 100% of all commodities are assumed treated. 

Processing factors for all registered or proposed crops were set to 1, based on the results of 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 371163

PC Code: 085651 

______________________________________________________________________________________

3

processing studies demonstrating that residues of cyazofamid in processed commodities would

not exceed the raw agricultural commodity (RAC) tolerances.

Acute Dietary Exposure Results

The unrefined acute dietary (food + water) exposure assessment was performed for females 13-

49 years old only, since an acute endpoint of concern was not identified for the general U.S. 

population. Based on the assumptions described above, acute dietary exposure of females 13-49

years old is well below HED’s level of concern at the 95th percentile of exposure. Combined 

dietary exposure from food and drinking water is estimated at 0.012139 mg/kg/day, equivalent to 

1.2% of the acute Population Adjusted Dose (aPAD). 

Chronic Dietary Exposure Results

Chronic dietary exposure estimates for food and drinking water combined are also well below 

HED’s level of concern. Using the DEEM-FCID software, dietary exposure for the general U.S. 

population is estimated at 0.004945 mg/kg/day, equivalent to <1% of the chronic Population 

Adjusted Dose (cPAD) and 0.011079 mg/kg/day, equivalent to 1.2% of the cPAD for infants <1

year old, the population subgroup with the highest estimated chronic dietary exposure to 

cyazofamid. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the 

reference dose (RfD) divided by the special Food Quality Protection Act (FQPA) Safety Factor.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (8/20/99).

The most recent HED dietary risk assessment for cyazofamid (D357043, Amelia M. Acierto, 

3/25/09) was conducted to support the FIFRA §3 registration on fruiting vegetables, okra and 

grapes. As in the 2009 dietary assessment, this current assessment incorporates drinking water 

directly into the dietary analyses.

II. Food Residue Information

Residues of Concern: The HED Metabolism Assessment Review Committee (MARC) 

concluded in a meeting on 2/18/04 that for the risk assessment and tolerance expression, parent 

and the metabolite designated as CCIM are the residues of concern for plant commodities. The 

MARC also concluded that cyazofamid and the metabolites designated as CCIM, CCIM-AM and 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 371163

PC Code: 085651 

______________________________________________________________________________________

4

CTCA are considered to be the major residues in water and should be included in the drinking 

water risk assessment. The current uses of cyazofamid fall under 40 CFR §180.6(a)(3) (i.e., 

there is no reasonable expectation of finite residues in livestock commodities). 

Tolerances: Tolerances have been established under 40 CFR §180.601 for the combined 

residues of cyazofamid and its metabolite CCIM [4-chloro-5-(4-methylphenyl)-1H-imidazole-2-

carbonitrile] in or on cucurbit vegetables, Group 9 (0.1 ppm); vegetable, fruiting, group 8 (0.40 

ppm); potato (0.02 ppm); okra (0.40 ppm), carrot, roots (0.09 ppm) and grapes (1.5 ppm). Turf

and ornamentals (non-food use sites) did not require establishment of additional tolerances.

Residue Data used for the Acute and Chronic Assessments: The unrefined acute and chronic 

analyses assumed that cyazofamid residues are present in/on all registered food commodities at 

tolerance levels and assumed 100% of all commodities are treated. There are no processing data 

for brassica (Cole) leafy vegetables crop group 5, turnip greens, spinach, and hops. The 

tolerance summary for cyazofamid used in the acute and chronic analyses for the proposed new 

uses are summarized below in Table 1. A complete listing of the residues used in the analyses 

are included in Attachments 1, and 3.

Table 1. Tolerance Summary for Cyazofamid Proposed Uses on Brassica Cole Leafy Vegetables Crop 

Group 5, Turnip Greens, Spinach and Hops.

Commodity

ProposedTolerance

(ppm)

Recommended 

Tolerances (ppm)

Tolerances Proposed 

under 40 

CFR§180.601

Brassica Head and Stem 

Subgroup 5A 1.2 1.2 1.2

Brassica Leafy Greens 

Subgroup 5B 12.0 12.0 12.0

Turnip greens 12.0 12.0 12.0

Spinach 9.0 9.0 9.0

Hops 10.0 10.0 10.0

III. Drinking Water Data

Reference: Estimated Drinking Water Concentrations of Parent Cyazofamid and its Degradates 

of Concern CCIM, CCIM-AM and CTCA, for Use in Human Health Risk Assessment: New 

Uses on Brassica (Cole) Leafy Vegetables & Turnip Greens (Crop Group 5), Spinach, and Hops; 

Jose L. Melendez, D370673, March 1, 2010.

The above memorandum from EFED is a drinking waters assessment (DWA) that presents the 

EDWCs for parent cyazofamid, and the degradates CCIM, CCIM-AM and CTCA for use in an 

FQPA human health risk assessment. Cyazofamid fungicide and/or its degradates may reach 

both surface and groundwater under some conditions. The degradates’ EDWCs were modeled 

individually (as opposed to the use of the total residue approach). This was done because 

sufficient data were available on the degradates to model them individually (although some 

assumptions were made, see below). It is noted that DWAs were previously issued as follows:
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 371163

PC Code: 085651 

______________________________________________________________________________________

5

Summary of Cyazofamid Drinking Water Exposure Assessments

Date DP Barcode Uses included

4/28/04 301099 Cucurbits, potatoes and tomatoes

9/6/06 319466 Turf and Ornamentals

3/5/08 342613 Carrots

3/24/09 356836 Fruiting vegetables + okra, and grapes (East of the Rocky mountains)

This DWA builds largely upon the previous assessments. Additional runs were performed to 

cover the new crops; the highest EDWCs of all crops (past and present) were obtained for turf 

and ornamentals (surface waters) and ornamentals (ground water). The screening-level surface 

water and ground water EDWCs were obtained using the tier 2 linked aquatic models PRZM/ 

EXAMS and the tier 1 aquatic model SCI-GROW, respectively. EDWCs are summarized in 

Table 2 for three scenarios as follows:

 1

st

scenario: the parent is applied at the maximum rate;

 2

nd scenario: the degradates CCIM and CCIM-AM (and CTCA) are applied at the parentmolar equivalent amounts, spreading the application rate through the degradates, 

according to the molecular ratios and the adjusted maximum percentages of the 

degradates observed in the environmental fate studies; and

 3

rd scenario: the terminal degradate, CTCA, is applied assuming application of 100% 

molar conversion of the parent to the degradate.

Based on the results presented in Table 2 below and a time-line of exposure, the surface water 

acute EDWC is 38.2 ppb (equal to the Parent “14.362 ppb” + CCIM “17.106 ppb” + CCIM-AM 

“6.699 ppb”). CTCA is not included in the surface water acute EDWC because it is not expected 

to be present in this time frame. The surface water non-cancer chronic is 133.5 ppb and the 

cancer chronic is 77.3 ppb (equal to the value for the terminal degradate, CTCA). For ground 

water, the EDWC is 2.18 ppb, which is suitable for acute and chronic exposures (equal to the 

value for the terminal degradate, CTCA).

Table 2. Maxima of surface and ground water EDWCs for cyazofamid and its relevant major 

degradates. Turf and ornamentals use pattern, previously reported in D319466 (dated 9/6/06).

Scenario Chemical

Surface water EDWCs (ppb) Ground 

water EDWC 

Acute (ppb)

Chronic “NonCancer”Chronic 

“Cancer”

1

st

 Scenario Cyazofamid 14.362 0.377 0.279 0.01180

2

nd

 Scenario

CCIM 17.106 12.094 10.600 0.00061

CCIM-AM 6.699 6.312 3.611 0.00270

3

rd

 Scenario CTCA 136.242 133.458 77.270 2.180

 EDWCs 38.2 133.5 77.3 2.18

The above stated values represent upper-bound estimates of the parent, individual degradates 

and/or terminal degradate concentrations that might be found in surface water and groundwater 

due to the use of cyazofamid on turf and ornamentals. EFED emphasizes that this is a screening 

level analysis and additional refinements could be made if needed.
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 6 of 16

Typically, HED uses the higher of the surface or groundwater estimates for each duration when 

assessing dietary risk. Therefore, although CTCA is not expected to be found in the acute time 

frame of exposure, HED will continue to use the EDWC which includes CTCA (136 ppb). This 

approach may significantly overestimate dietary exposure to cyazofamid from drinking water,

however, since estimated aggregate food and drinking water exposures using this approach are 

well below the acute and chronic levels of concern, additional refinements were not deemed 

necessary.

 

IV. DEEM-FCIDTM Program and Consumption Information

Cyazofamid acute and chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database (DEEMFCIDTM, Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys 

of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on 

the reported consumption of more than 20,000 individuals over two non-consecutive survey

days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. 

apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) 

using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For 

chronic exposure assessment, consumption data are averaged for the entire U.S. population and 

within population subgroups, but for acute exposure assessment are retained as individual 

consumption events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took 

into account dietary patterns and survey respondents, HED concluded that it is most appropriate 

to report risk for the following population subgroups: the general U.S. population, all infants (<1 

year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, 

and adults 50+ years old.

For chronic dietary exposure assessments, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, any

significant differences in user vs. per capita exposure and risk are specifically identified and 

noted in the risk assessment.
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 7 of 16

V. Toxicological Information

The toxicology database for cyazofamid with regard to the acute and chronic reference doses 

(RfDs) remain unchanged. The rationale for toxicity endpoint selection was discussed in detail 

in the most recent human health risk assessment document (D356837, N. Tsaur, 5/5/20009) and 

will not be repeated here. However, the doses and toxicological endpoints selected for dietary

risk assessments are summarized in Table 3. 

.

Table 3. Summary of Cyazofamid Toxicological Doses and Endpoints for Dietary Risk Assessment.

Exposure

Scenario

Dose Used in Risk 

Assessment, UF 

FQPA SF and Level of 

Concern for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary

(Females 13-49

years of age)

NOAEL = 100 mg/kg

UF = 100

Acute RfD = 1.0 mg/kg

FQPA SF = 1X

aPAD = acute RfD

 FQPA SF

= 1.0 mg/kg

Rat Prenatal Developmental Toxicity 

(MRID 45408933)

LOAEL = 1,000 mg/kg based on 

developmental toxicity findings of 

increased incidence of bent ribs.

Acute Dietary

(General 

population 

including infants 

and children)

NOAEL = NA

UF = NA

Acute RfD = NA 

FQPA SF = NA

aPAD = acute RfD

 FQPA SF

= NA

No adverse effects were observed 

which could be attributed to a 

single-dose exposure.

Chronic Dietary

(All populations)

NOAEL= 94.8 

mg/kg/day

UF = 100

Chronic RfD = 0.95

mg/kg/day

FQPA SF = 1X

cPAD = chronic RfD

 FQPA SF

= 0.95 mg/kg/day

18-Month Mouse Oral 

Carcinogenicity (MRID 45408932)

LOAEL = 985 mg/kg/day based on 

increased skin lesions.

UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOAEL = no-observed-adverse-effect-level, 

LOAEL = lowest-observed-adverse-effect-level, PAD = population adjusted dose (a = acute, c = chronic) RfD = 

reference dose, NA = Not Applicable

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The acute exposure results are reported in Tables 

4 for females 13-49 only. The chronic results reported in Table 5 are for the general U.S. 

Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years. 

Results of Acute Dietary Exposure Analysis

The Tier 1 acute dietary (food + drinking water) exposure assessment was performed for females 

13-49 years old only, since an acute endpoint of concern was not identified for the general 
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 8 of 16

population. Based on the assumptions described above in sections II and III, acute dietary

exposure of females 13-49 years old is well below HED’s level of concern (i.e., <100% of the 

aPAD of 1.0 mg/kg). The combined dietary exposure from food and drinking water is estimated 

at 0.012139 mg/kg/day (equivalent to 1.2% of the aPAD), at the 95th percentile of exposure, the 

appropriate regulatory statistic for Tier 1 dietary assessments as shown in Table 4. 

Table 4. Results of Acute Dietary Exposure Analysis for Food and Drinking Water at the 95th Percentile of 

Exposure using DEEM FCID

Population 

Subgroup

aPAD 

(mg/kg/day)

95th Percentile 99th Percentile 99.9th Percentile

Exposure 

(mg/kg/day)

% aPAD Exposure 

(mg/kg/day)

% aPAD Exposure 

(mg/kg/day)

% aPAD

Females 13-49

years old 1 0.012139 1.2 0.024480 2.45 0.059739 5.97

 

Results of Chronic Dietary Exposure Analysis

Cyazofamid chronic dietary (food + water) exposure estimates using the DEEM-FCIDTM 

software are well below HED’s level of concern for the general U.S. population and each of the 

population subgroups. Dietary exposure was estimated at 0.004945 mg/kg/day for the U.S. 

population (<1% of the cPAD) and 0.011079 mg/kg/day (1.2% of the cPAD) for the most highly

exposed population subgroup (infants <1 year old). The estimated exposures/risks for food and

drinking water are summarized in Table 5 for all populations.

Table 5. Results of Chronic Dietary Exposure Analysis for Food and Drinking Water

Population Subgroup

 Exposure

(mg/kg/day)

% cPAD

General U.S. Population 0.004945 <1

All Infants (< 1 year old)10.011079 1.2

Children 1-2 years old 0.010749 1

Children 3-5 years old 0.008556 <1

Children 6-12 years old 0.004916 <1

Youth 13-19 years old 0.003393 <1

Adults 20-49 years old 0.004351 <1

Adults 50+ years old 0.004884 <1

Females 13-49 years old 0.004302 <1

1The population subgroup with the highest estimated chronic dietary (food + drinking water)

exposure and risk is indicated by bold text.
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 9 of 16

 

.

VII. Characterization of Inputs/Outputs

These acute and chronic dietary exposure and risk estimates are conservative since they assume 

that 100% of crops are treated with cyazofamid and that residues are present at tolerance levels. 

In addition, drinking water exposure estimates were based on screening level estimates generated 

by the PRZM-EXAMS model. Dietary exposure estimates could be refined through the use of 

anticipated residues and percent crop treated data, as well as refined estimated drinking water 

concentrations. However, since estimated exposures and risks using conservative assumptions 

are well below HED’s level of concern, such refinement is not warranted.

VIII. Conclusions

These unrefined, Tier 1 dietary exposure analyses using DEEM-FCIDTM indicate that acute and 

chronic dietary exposures to cyazofamid from food and drinking water are well below HED’s 

level of concern for this pesticide. The estimated acute exposure of females 13-49 years old, the 

only population subgroup of concern for acute exposure, represents 1.2% of the aPAD at the 95th

percentile of exposure. Estimated chronic dietary exposures are less than or equal to 1.2% of the 

cPAD for the general U.S. population and all population subgroups.

IX. List of Attachments

Acute Food + Drinking Water Input File

Acute Food + Drinking Water Results File

Chronic Food + Drinking Water Input File

Chronic Food + Drinking Water Results File
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 10 of 16

Chronic Food + Drinking Water Input File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for CYAZOFAMID 1994-98 data

Residue file: C:\Documents and Settings\aacierto\Desktop\DEEM-FCID 

Files\DEEM2010\Chronic cyazofamid food+water.R98 Adjust. #2 NOT used 

Analysis Date 03-16-2010 Residue file dated: 03-16-2010/13:48:52/8

Reference dose (RfD) = 0.95 (NOEL) = 94.8 mg/kg bw/day

Comment:Drinking Water using CTCA Drinking Water estimate (scenario #3)

----------------------------------------------------------------------------

Food Crop Residue Adj.Factors 

Comment

EPA Code Grp Food Name (ppm) 

 #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ 

09020210 9B Balsam pear 0.100000 1.000 1.000 

05010610 5A Broccoli 1.200000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.200000 1.000 1.000 

05010620 5A Broccoli, Chinese 1.200000 1.000 1.000 

05020630 5B Broccoli raab 12.000000 1.000 1.000 

05010640 5A Brussels sprouts 1.200000 1.000 1.000 

05010690 5A Cabbage 1.200000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 

09010750 9A Cantaloupe 0.100000 1.000 1.000 

01010780 1AB Carrot 0.090000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.090000 1.000 1.000 

09010800 9A Casaba 0.100000 1.000 1.000 

05010830 5A Cauliflower 1.200000 1.000 1.000 

09020880 9B Chayote, fruit 0.100000 1.000 1.000 

09021020 9B Chinese waxgourd 0.100000 1.000 1.000 

05021170 5B Collards 12.000000 1.000 1.000 

09021350 9B Cucumber 0.100000 1.000 1.000 

95001750 O Grape 1.500000 1.000 1.000 

95001760 O Grape, juice 1.500000 1.000 1.000 

95001761 O Grape, juice-babyfood 1.500000 1.000 1.000 

95001770 O Grape, leaves 1.500000 1.000 1.000 

95001780 O Grape, raisin 1.500000 1.000 1.000 

95001790 O Grape, wine and sherry 1.500000 1.000 1.000 

09011870 9A Honeydew melon 0.100000 1.000 1.000 

95001880 O Hop 10.000000 1.000 1.000 

05021940 5B Kale 12.000000 1.000 1.000 

05011960 5A Kohlrabi 1.200000 1.000 1.000 

05022290 5B Mustard greens 12.000000 1.000 1.000 

08002340 8 Okra 0.400000 1.000 1.000 

08002700 8 Pepper, bell 0.400000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.400000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.400000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.400000 1.000 1.000 

08002720 8 Pepper, nonbell 0.400000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.400000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.400000 1.000 1.000 

01032960 1C Potato, chips 0.020000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 11 of 16

01032971 1C Potato, dry (granules/ flakes)-b 0.020000 1.000 1.000 

01032980 1C Potato, flour 0.020000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.020000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

09023080 9B Pumpkin 0.100000 1.000 1.000 

09023090 9B Pumpkin, seed 0.100000 1.000 1.000 

05023180 5B Rape greens 12.000000 1.000 1.000 

04013550 4A Spinach 9.000000 1.000 1.000 

09023560 9B Squash, summer 0.100000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.100000 1.000 1.000 

09023570 9B Squash, winter 0.100000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.100000 1.000 1.000 

08003740 8 Tomatillo 0.400000 1.000 1.000 

08003750 8 Tomato 0.400000 1.000 1.000 

08003751 8 Tomato-babyfood 0.400000 1.000 1.000 

08003760 8 Tomato, paste 0.400000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 0.400000 1.000 1.000 

08003770 8 Tomato, puree 0.400000 1.000 1.000 

08003771 8 Tomato, puree-babyfood 0.400000 1.000 1.000 

08003780 8 Tomato, dried 0.400000 1.000 1.000 

08003781 8 Tomato, dried-babyfood 0.400000 1.000 1.000 

08003790 8 Tomato, juice 0.400000 1.000 1.000 

95003800 O Tomato, Tree 0.200000 1.000 1.000 

05023890 5B Turnip, greens 12.000000 1.000 1.000 

86010000 O Water, direct, all sources 0.133000 1.000 1.000 

86020000 O Water, indirect, all sources 0.133000 1.000 1.000 

09013990 9A Watermelon 0.100000 1.000 1.000 

09014000 9A Watermelon, juice 0.100000 1.000 1.000 
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 12 of 16

Chronic Food + Drinking Water Results File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for CYAZOFAMID (1994-98 data)

Residue file name: C:\Documents and Settings\aacierto\Desktop\DEEM-FCID 

Files\DEEM2010\Chronic cyazofamid food+water.R98

 Adjustment factor #2 NOT used.

Analysis Date 03-16-2010/13:52:31 Residue file dated: 03-16-2010/13:48:52/8

Reference dose (RfD, Chronic) = .95 mg/kg bw/day

NOEL (Chronic) = 94.8 mg/kg bw/day

COMMENT 1: Drinking Water using CTCA Drinking Water estimate (scenario #3)

=============================================================================

 Total exposure by population subgroup

-----------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Margin of Percent 

 Subgroup body wt/day Exposure 1/ of RfD 

-------------------------------------- ------------- ---------- ---------

U.S. Population (total) 0.004945 19,170 0.5%

U.S. Population (spring season) 0.004835 19,607 0.5%

U.S. Population (summer season) 0.005231 18,123 0.6%

U.S. Population (autumn season) 0.004869 19,469 0.5%

U.S. Population (winter season) 0.004838 19,595 0.5%

Northeast region 0.004930 19,231 0.5%

Midwest region 0.004722 20,075 0.5%

Southern region 0.004802 19,743 0.5%

Western region 0.005426 17,470 0.6%

Hispanics 0.004836 19,603 0.5%

Non-hispanic whites 0.004649 20,390 0.5%

Non-hispanic blacks 0.006007 15,781 0.6%

Non-hisp/non-white/non-black 0.007056 13,436 0.7%

All infants (< 1 year) 0.011079 8,557 1.2%

Nursing infants 0.004345 21,817 0.5%

Non-nursing infants 0.013634 6,953 1.4%

Children 1-6 yrs 0.008929 10,617 0.9%

Children 7-12 yrs 0.004649 20,394 0.5%

Females 13-19 (not preg or nursing) 0.003240 29,256 0.3%

Females 20+ (not preg or nursing) 0.004777 19,844 0.5%

Females 13-50 yrs 0.004422 21,440 0.5%

Females 13+ (preg/not nursing) 0.003590 26,403 0.4%

Females 13+ (nursing) 0.005594 16,945 0.6%

Males 13-19 yrs 0.003526 26,884 0.4%

Males 20+ yrs 0.004303 22,034 0.5%

Seniors 55+ 0.004900 19,347 0.5%

Children 1-2 yrs 0.010749 8,819 1.1%

Children 3-5 yrs 0.008556 11,081 0.9%

Children 6-12 yrs 0.004916 19,283 0.5%

Youth 13-19 yrs 0.003393 27,936 0.4%
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 13 of 16

Adults 20-49 yrs 0.004351 21,789 0.5%

Adults 50+ yrs 0.004884 19,411 0.5%

Females 13-49 yrs 0.004302 22,034 0.5%

-----------------------------------------------------------------------------
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 14 of 16

Acute Food + Drinking Water Input File

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID Acute analysis for CYAZOFAMID

Residue file name: C:\Documents and Settings\aacierto\Desktop\DEEM-FCID 

Files\DEEM2010\acute cyazofamid food+water.R98

Analysis Date 03-16-2010 Residue file dated: 03-16-2010/13:34:40/8

Reference dose: aRfD = 1 mg/kg bw/day NOEL = 100 mg/kg bw/day

Comment: Drinking Water using CTCA Drinking Water estimate (scenario #3)

----------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors 

Comment

 Code Grp Food Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ---

----

09020210 9B Balsam pear 0.100000 1.000 1.000

05010610 5A Broccoli 1.200000 1.000 1.000

05010611 5A Broccoli-babyfood 1.200000 1.000 1.000

05010620 5A Broccoli, Chinese 1.200000 1.000 1.000

05020630 5B Broccoli raab 12.000000 1.000 1.000

05010640 5A Brussels sprouts 1.200000 1.000 1.000

05010690 5A Cabbage 1.200000 1.000 1.000

05020700 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000

05010710 5A Cabbage, Chinese, napa 1.200000 1.000 1.000

05010720 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000

09010750 9A Cantaloupe 0.100000 1.000 1.000

01010780 1AB Carrot 0.090000 1.000 1.000

01010781 1AB Carrot-babyfood 0.090000 1.000 1.000

09010800 9A Casaba 0.100000 1.000 1.000

05010830 5A Cauliflower 1.200000 1.000 1.000

09020880 9B Chayote, fruit 0.100000 1.000 1.000

09021020 9B Chinese waxgourd 0.100000 1.000 1.000

05021170 5B Collards 12.000000 1.000 1.000

09021350 9B Cucumber 0.100000 1.000 1.000

08001480 8 Eggplant 0.400000 1.000 1.000

95001750 O Grape 1.500000 1.000 1.000

95001760 O Grape, juice 1.500000 1.000 1.000

95001761 O Grape, juice-babyfood 1.500000 1.000 1.000

95001770 O Grape, leaves 1.500000 1.000 1.000

95001780 O Grape, raisin 1.500000 1.000 1.000

95001790 O Grape, wine and sherry 1.500000 1.000 1.000

09011870 9A Honeydew melon 0.100000 1.000 1.000

95001880 O Hop 10.000000 1.000 1.000

05021940 5B Kale 12.000000 1.000 1.000

05011960 5A Kohlrabi 1.200000 1.000 1.000

05022290 5B Mustard greens 12.000000 1.000 1.000

08002340 8 Okra 0.400000 1.000 1.000

08002700 8 Pepper, bell 0.400000 1.000 1.000

08002701 8 Pepper, bell-babyfood 0.400000 1.000 1.000

08002710 8 Pepper, bell, dried 0.400000 1.000 1.000

08002711 8 Pepper, bell, dried-babyfood 0.400000 1.000 1.000

08002720 8 Pepper, nonbell 0.400000 1.000 1.000

08002721 8 Pepper, nonbell-babyfood 0.400000 1.000 1.000

08002730 8 Pepper, nonbell, dried 0.400000 1.000 1.000

01032960 1C Potato, chips 0.020000 1.000 1.000

01032970 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 15 of 16

01032971 1C Potato, dry (granules/ flakes)-b 0.020000 1.000 1.000

01032980 1C Potato, flour 0.020000 1.000 1.000

01032981 1C Potato, flour-babyfood 0.020000 1.000 1.000

01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000

01032991 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000

01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000

01033001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000

09023080 9B Pumpkin 0.100000 1.000 1.000

09023090 9B Pumpkin, seed 0.100000 1.000 1.000

05023180 5B Rape greens 12.000000 1.000 1.000

04013550 4A Spinach 9.000000 1.000 1.000

09023560 9B Squash, summer 0.100000 1.000 1.000

09023561 9B Squash, summer-babyfood 0.100000 1.000 1.000

09023570 9B Squash, winter 0.100000 1.000 1.000

09023571 9B Squash, winter-babyfood 0.100000 1.000 1.000

08003740 8 Tomatillo 0.400000 1.000 1.000

08003750 8 Tomato 0.400000 1.000 1.000

08003751 8 Tomato-babyfood 0.400000 1.000 1.000

08003760 8 Tomato, paste 0.400000 1.000 1.000

08003761 8 Tomato, paste-babyfood 0.400000 1.000 1.000

08003770 8 Tomato, puree 0.400000 1.000 1.000

08003771 8 Tomato, puree-babyfood 0.400000 1.000 1.000

08003780 8 Tomato, dried 0.400000 1.000 1.000

08003781 8 Tomato, dried-babyfood 0.400000 1.000 1.000

08003790 8 Tomato, juice 0.400000 1.000 1.000

95003800 O Tomato, Tree 0.200000 1.000 1.000

05023890 5B Turnip, greens 12.000000 1.000 1.000

86010000 O Water, direct, all sources 0.136000 1.000 1.000

86020000 O Water, indirect, all sources 0.136000 1.000 1.000

09013990 9A Watermelon 0.100000 1.000 1.000

09014000 9A Watermelon, juice 0.100000 1.000 1.000
Cyazofamid Dietary Exposure Assessment DP Number: 343442 PC Code: 085651

_____________________________________________________________________________________________

Page 16 of 16

Acute Food + Drinking Water Results File

U.S. Environmental Protection Agency Ver. 

2.02

DEEM-FCID ACUTE Analysis for CYAZOFAMID (1994-98 data)

Residue file: acute cyazofamid food+water.R98 Adjustment factor #2 NOT used.

Analysis Date: 03-16-2010/13:37:03 Residue file dated: 03-16-2010/13:34:40/8

NOEL (Acute) = 100.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment:"Drinking Water using CTCA Drinking Water estimate (scenario #3)"

=============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ----------

U.S. Population:

0.014299 1.43 6993 0.031974 3.20 3127 0.071845 7.18 1391 

Females 13-49 yrs:

0.012139 1.21 8237 0.024480 2.45 4085 0.059739 5.97 1673