Exhibit 10.36



 EXHIBIT 10.36 

CONFIDENTIAL TREATMENT REQUESTED 

Final Execution Copy 

UNIVERSITY of PENNSYLVANIA 

Third Amendment to License Agreement 

This Third Amendment to License Agreement (this “Third Amendment”) effective as of April 29, 2016 (this “Third Amendment
Effective Date”), is made by and between The Trustees of the University of Pennsylvania (“Penn”) and REGENXBIO Inc. (“Company”) (collectively, the “Parties”) and amends the License
Agreement between the Parties, which was effective as of February 24, 2009, as subsequently amended by a First Amendment dated March 6, 2009 and a Second Amendment dated September 9, 2014 (the “License Agreement”).
All capitalized terms used but not defined herein shall have the meaning set forth in the License Agreement. 
 BACKGROUND 

WHEREAS, the Parties are simultaneously entering into a Clinical Trial Research Agreement relating to evaluation of the safety of AAV8.TBG.hLDLR, a
replication deficient recombinant adeno-associated virus vector 8 (AAV8) expressing human Low Density Lipoprotein receptor (LDLR) from liver-specific thyroxine-binding globulin (TBG) promoter, (the “Study Drug”) in certain patients with
Homozygous Familial Hypercholesterolemia (HoFH) in a Phase 1/2 clinical trial as set forth in the Clinical Trial Research Agreement (the “Study”); 

WHEREAS, Company wishes to license, and Penn agrees to provide to Company with, a license to data, results and other information generated in connection with
the Study in the furtherance of Company’s commercialization objectives, including Company’s intention to seek marketing authorization from the FDA and other regulatory authorities for the Study Drug and the treatment of patients with HoFH;
and 
 WHEREAS, the Parties desire that the License Agreement be amended as set forth below in order to amend the license grants to include within the scope
of the License Agreement certain rights to data, results and other information generated from the Study; 
 NOW, THEREFORE, in consideration of the mutual
covenants and promises contained herein, the Parties, intending to be bound, hereby mutually agree to the following: 
  

	1.	The following definitions in Section 1.2 of the License Agreement shall be amended and restated in their entirety as follows: 


“Background Know-How” means all (i) Know-How that
(a) was developed by Dr. Wilson, or other Penn researchers working under his direct supervision, at Penn, and (b) is related to the adeno associated virus technology platform discovered by Dr. Wilson at Penn prior to
September 9, 2014 or is related to the adeno associated virus technology platform discovered by Dr. Wilson at Penn during the performance of a Company sponsored research program 








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after September 9, 2014, and (c) is owned by Penn, (d) is necessary or useful for the practice of the Patent Rights in connection with the manufacture, use, sale, importation
and/or other exploitation of the Licensed Products or the practice of the Licensed Processes in the Territory in the Field of Use, including, without, limitation, any Know-How necessary for the Company to
manufacture or have manufactured the materials produced by the Penn Vector Core or Dr. Wilson’s lab at Penn; and (ii) Penn Study Data. 

“Field of Use” means any and all fields of use, except with respect to (i) the Patent Rights listed in Exhibit A, Part 2 and all related
Know-How and data, for which the Field of Use is limited to viral vector mediated gene therapy, and (ii) the Penn Study Data, for which the Field of Use is limited to the treatment of familial
hypercholesterolemia (FH). 
 “Licensed Products” means any products that are made, made for, used, imported, offered for sale or sold by
or for Company or its Affiliates or sublicensees and that either (i) in the absence of this Agreement, would infringe or misappropriate the Licensed IP, or any claim thereof whether or not the claim is issued or pending, or (ii) use, or
are manufactured using, a Licensed Process, or (iii) rely on the Penn Study Data in connection with the regulatory approval of such a product for treating FH, or (iv) are supported by Penn Study Data that corresponds to and/or supports the
patentability of such product or its use in the field. Licensed Products include Licensed Pharmaceutical Products and Licensed Reagents. 
  

	2.	The following definitions shall be added to Section 1.2 of the License Agreement: 

 “Clinical
Research” means all those tests, studies and other activities described in the Protocol or required in order to obtain the information set out in the Protocol together with such other activities as may be agreed on to be undertaken by Penn
and Company in accordance with Clinical Trial Research Agreement between Penn and the Company dated April 29, 2016 (the “HoFH CTRA”). 

“Penn Study Data” means all data and information that are generated in the performance of the Clinical Research during the term of this
Agreement. 
 “Protocol” means a description of the research to be undertaken by Penn and/or Company as set forth in Exhibit A of the HoFH
CTRA, as may be amended pursuant to Section 20 of the HoFH CTRA. 
  

	3.	The following definitions in Section 3.5 of the License Agreement shall be amended and restated in their entirety as follows: 


“Royalty Term” means, on a product-by-product, country-by-country basis with respect to Licensed Products in a Field of Use other than for treating FH, the period commencing on the date of the first Sale of such Licensed
Product and ending on the date the Licensed Product ceases to be covered by a valid claim (issued or pending) of the Patent Rights. With respect to Licensed Products for treating FH, “Royalty Term” means, on a product-by-product, 

  
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country-by-country basis, the period commencing on date of the first Sale of such Licensed Product for treating FH
and ending on the later of: (i) the date the Licensed Product for treating FH ceases to be infringed or covered by a valid claim (issued or pending) of the Patent Rights, and (ii) seven (7) years following the first Sale of such Licensed
Product for treating FH. 
 4. Exhibit A of the License Agreement is hereby amended and restated in its entirety by Exhibit
A-1 to this Third Amendment to add the additional Patent Rights and Know-How. 

5. This Third Amendment amends the terms of the License Agreement and is deemed incorporated into, and governed by all other terms of, the License Agreement.
To the extent that the License Agreement is explicitly amended by this Third Amendment, the terms of this Third Amendment will control where the terms of the License Agreement are contrary to or conflict with the terms of this Third Amendment. All
other terms and conditions of the License Agreement not explicitly amended by this Third Amendment shall remain in full force and effect. The License Agreement, as previously amended, shall, together with this Third Amendment, be read and construed
as a single instrument. 
 6. Signatures on this Third Amendment may be communicated by facsimile or e-mail
transmission and shall be binding upon the Parties upon receipt by transmitting the same by facsimile or e-mail transmission, which signatures shall be deemed originals. If executed in counterparts, the Third
Amendment shall be effective as if simultaneously executed. 
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 IN WITNESS WHEREOF, the Parties, intending to be legally bound, have caused this Third Amendment to be
executed by their duly authorized representatives. 
  

			
	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
		
	By:	 	 /s/ John S. Swartley, PhD

	Name:	 	John S. Swartley, PhD
	Title:	 	Associate Vice Provost for Research and Executive Director, PCI
	Date:	 	 June 2, 2016

	
	REGENXBIO INC.
		
	By:	 	 /s/ Kenneth T. Mills

	Name:	 	Kenneth T. Mills
	Title:	 	President and CEO
	Date:	 	 June 6, 2016



  
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 Exhibit A-1 

Patents and Patent Applications in the Patent Rights 

Part 1; No Field of Use Limitation 
  

													
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	 Docket V5085
	  	 	  	 Combinational method to generate
novel and/or hybrid coding sequences within the defined domains

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	 Docket V5131
	  	 A domain of the adeno-associated
virus stereotype 6 capsid that confers transduction of conducting airway
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	 Docket X5836
	  	 The receptor for AAV9 and its
modification in vivo to improve lung gene therapy
	  	 
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	****	  		  	****	  	****	  	****	  	****	  	
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	****	  		  	****	  	****	  	****	  	****	  	
	****	  		  	****	  	****	  	****	  	****	  	
	****	  		  	****	  	****	  	****	  	****	  	
			
	 Docket Z6622
	  	 	  	 Compositions and Methods for
Treatingment of MPSI1

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	****	  		  	****	  	****	  	****	  	****	  	
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	****	  		  	****	  	****	  	****	  	****	  	
	****	  		  	****	  	****	  	****	  	****	  	

 Exhibit A, Part 2- 

Field of Use limited to viral vector mediated delivery of gene therapy product. 

 

													
	 Docket
14-7025
	  	 	  	 Improved AAV-LDLR for treating human disease

	 Serial No
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	****	  		  	****	  	****	  	****	  	****	  	
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	****	  		  	****	  	****	  	****	  	****	  	
			
	 Docket
14-7037
	  	 	  	 AAV OTC for treating human
disease

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	****	  		  	****	  	****	  	****	  	****	  	
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	  	 	  	 Methods and compositions for
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	****	  		  	****	  	****	  	****	  	****	  	
	****	  		  	****	  	****	  	****	  	****	  	
			
	
Docket 15-7487
	  	 	  	 Compositions and Methods for
Treating MPSI

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	****	  		  	****	  	****	  	****	  	****	  	

 Penn / Wilson Lab Know-How for the Familial Hypercholesterolemia and Onithine
Transcarbamylase Deficiency (OTC) Programs 
 FH Know-How (associated with ****) 

**** 
 OTC Know-How
(associated with ****) 
 **** 

  
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