# Patent

## Title
Heterocyclic diamide invertebrate pest control agents

## Abstract

This invention provides compounds of Formula (I), N-oxides and suitable salts thereof, wherein A and B are independently O or S; each J is independently a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R5; K is, together with the two contiguous linking carbon atoms, a 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 3 R4; and R1 R2, R3, R4, R5 and n are as defined in the disclosure. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents.

## Background
BACKGROUND OF THE INVENTION
This invention relates to certain heterocyclic diamides, their N-oxides, suitable salts and compositions, and a method of their use for controlling invertebrate pests in both agronomic and nonagronomic environments.
The control of invertebrate pests is extremely important in achieving high crop efficiency. Damage by invertebrate pests to growing and stored agronomic crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. The control of invertebrate pests in forestry, greenhouse crops, ornamentals, nursery crops, stored food and fiber products, livestock, household, and public and animal health is also important. Many products are commercially available for these purposes, but the need continues for new compounds that are more effective, less costly, less toxic, environmentally safer or have different modes of action.
NL 9202078 discloses N-acyl anthranilic acid derivatives of Formula i as insecticides




wherein inter alia, X is a direct bond; Y is H or C1-C6 alkyl; Z is NH2, NH(C1-C3 alkyl) or N(C1-C3 alkyl)2; and R1 through R9 are independently H, halogen, C1-C6 alkyl, phenyl, hydroxy, C1-C6 alkoxy or C1-C7 acyloxy.

WO01/070671 discloses N-acyl anthranilic acid derivatives of Formula i as arthropodicides




wherein, inter alia, A and B are independently O or S; J is an optionally substituted phenyl ring, 5- or 6-membered heteroaromatic ring, naphthyl ring system or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system; R1 and R3 are independently H or optionally substituted C1-C6 alkyl; R2 is H or C1-C6 alkyl; each R4 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, halogen or CN; and n is 1 to 4.

SUMMARY OF THE INVENTION
This invention pertains to compounds of Formula I, and N-oxides or suitable salts thereof




wherein

    
    
        A and B are independently O or S;
        each J is independently a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R5;
        K is, together with the two contiguous linking carbon atoms, a 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 3 R4;
        n is 1 to 3;
        R1 is H; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, each optionally substituted with one or more substituents selected from the group consisting of halogen, CN, NO2, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C2-C4 alkoxycarbonyl, C1-C4 alkylamino, C2-C8 dialkylamino and C3-C6 cycloalkylamino; or
        R1 is C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C(=A)J;
        R2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C4 alkoxy, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C2-C6 alkoxycarbonyl or C2-C6 alkylcarbonyl;
        R3 is H; G; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, each optionally substituted with one or more substituents selected from the group consisting of G, halogen, CN, NO2, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylcarbonyl, C3-C6 trialkylsilyl, and a phenyl, phenoxy or 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R6; or
        R2 and R3 can be taken together with the nitrogen to which they are attached to form a ring containing 2 to 6 atoms of carbon and optionally one additional atom of nitrogen, sulfur or oxygen, and said ring may be optionally substituted with one to four substituents selected from R12; and
        G is a 5- or 6-membered nonaromatic carbocyclic or heterocyclic ring, optionally including one or two ring members selected from the group consisting of C(═O), SO and S(O)2, and optionally substituted with one to four substituents selected from R12;
        each R4 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, NO2, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C1-C4 alkoxyalkyl, C1-C4 hydroxyalkyl, C(O)R10, CO2R10, C(O)NR10R11, NR10R11, N(R11)CO2R10; or
        each R4 is independently a phenyl, benzyl, phenoxy or 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R6;
        each R5 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, CO2H, CONH2, NO2, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl, C3-C6 trialkylsilyl; or
        each R5 is independently a phenyl, benzyl, benzoyl, phenoxy, 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system, each ring or ring system optionally substituted with one to three substituents independently selected from R6; or
        (R5)2 when attached to adjacent carbon atoms can be taken together as —OCF2O—, —CF2CF2O—, or —OCF2CF2O—; and
        each R6 is independently C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, NO2, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C4-C6 (alkyl)cycloalkylamino, C2-C4 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C3-C6 trialkylsilyl;
        each R10 is independently H, C1-C4 alkyl or C1-C4 haloalkyl;
        each R11is independently H or C1-C4 alkyl; and
        each R12 is independently C1-C2 alkyl, halogen, CN, NO2 or C1-C2 alkoxy.
    
    


This invention also pertains to a method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also relates to such a method wherein the invertebrate pest or its environment is contacted with a biologically effective amount of a compound of Formula I or a composition comprising a compound of Formula I, an N-oxide thereof or a suitable salt of the compound and a biologically effective amount of at least one additional compound or agent for controlling invertebrate pests.
This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. This invention also pertains to a composition comprising a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt of the compound and an effective amount of at least one additional biologically active compound or agent.
DETAILS OF THE INVENTION
In the above recitations, the term “alkyl”, used either alone or in compound words such as “alkylthio” or “haloalkyl” includes straight-chain or branched alkyl, such as, methyl, ethyl, n-propyl, i-propyl, or the different butyl, pentyl or hexyl isomers. “Alkenyl” includes straight-chain or branched alkenes such as ethenyl, 1-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers. “Alkenyl” also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. “Alkynyl” includes straight-chain or branched alkynes such as ethynyl, 1-propynyl, 2-propynyl and the different butynyl, pentynyl and hexynyl isomers. “Alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl. “Alkoxy” includes, for example, methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butoxy, pentoxy and hexyloxy isomers. “Alkoxyalkyl” denotes alkoxy substitution on alkyl. Examples of “alkoxyalkyl” include CH3OCH2, CH3OCH2CH2, CH3CH2OCH2, CH3CH2CH2CH2OCH2 and CH3CH2OCH2CH2. “Alkylthio” includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, and the different propylthio and butylthio isomers. “Alkylsulfinyl” includes both enantiomers of an alkylsulfinyl group. Examples of “alkylsulfinyl” include CH3S(O), CH3CH2S(O), CH3CH2CH2S(O), (CH3)2CHS(O) and the different butylsulfinyl isomers. Examples of “alkylsulfonyl” include CH3S(O)2, CH3CH2S(O)2, CH3CH2CH2S(O)2, (CH3)2CHS(O)2 and the different butylsulfonyl isomers. “Alkylamino”, “dialkylamino”, “alkenylthio”, “alkenylsulfinyl”, “alkenylsulfonyl”, “alkynylthio”, “alkynylsulfinyl”, “alkynylsulfonyl”, and the like, are defined analogously to the above examples. “Cycloalkyl” includes, for example, cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.
“Aromatic” indicates that each of the ring atoms is essentially in the same plane and has a p-orbital perpendicular to the ring plane, and in which (4n+2) π electrons, when n is 0 or a positive integer, are associated with the ring to comply with Hückel's rule. The term “aromatic ring system” denotes fully unsaturated carbocycles and heterocycles in which at least one ring of a polycyclic ring system is aromatic. The term “aromatic carbocyclic ring or ring system” includes fully aromatic carbocycles and carbocycles in which at least one ring of a polycyclic ring system is aromatic (e.g. phenyl and naphthyl). The term “nonaromatic carbocyclic ring or ring system” denotes fully saturated carbocycles as well as partially or fully unsaturated carbocycles where the Hückel rule is not satisfied by any of the rings in the ring system. The term “hetero” in connection with rings or ring systems refers to a ring or ring system in which at least one ring atom is not carbon and which can contain 1 to 4 heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur, provided that each ring contains no more than 4 nitrogens, no more than 2 oxygens and no more than 2 sulfurs. The terms “heteroaromatic ring or ring system” and “aromatic fused heterobicyclic ring system” includes fully aromatic heterocycles and heterocycles in which at least one ring of a polycyclic ring system is aromatic (where aromatic indicates that the Hückel rule is satisfied). The term “nonaromatic heterocyclic ring or ring system” denotes fully saturated heterocycles as well as partially or fully unsaturated heterocycles where the Hückel rule is not satisfied by any of the rings in the ring system. The heterocyclic ring or ring system can be attached through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.
The term “halogen”, either alone or in compound words such as “haloalkyl”, includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as “haloalkyl”, said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Examples of “haloalkyl” include F3C, ClCH2, CF3CH2 and CF3CCl2. The terms “haloalkenyl”, “haloalkynyl”, “haloalkoxy”, “haloalkylthio”, and the like, are defined analogously to the term “haloalkyl”. Examples of “haloalkenyl” include (Cl)2C═CHCH2 and CF3CH2CH═CHCH2. Examples of “haloalkynyl” include HC≡CCHCl, CF3C≡C, CCl3C≡C and FCH2C≡CCH2. Examples of “haloalkoxy” include CF3O, CCl3CH2O, HCF2CH2CH2O and CF3CH2O. Examples of “haloalkylthio” include CCl3S, CF3S, CCl3CH2S and ClCH2CH2CH2S. Examples of “haloalkylsulfinyl” include CF3S(O), CCl3S(O), CF3CH2S(O) and CF3CF2S(O). Examples of “haloalkylsulfonyl” include CF3S(O)2, CCl3S(O)2, CF3CH2S(O)2 and CF3CF2S(O)2.
Examples of “alkylcarbonyl” include C(O)CH3, C(O)CH2CH2CH3 and C(O)CH(CH3)2. Examples of “alkoxycarbonyl” include CH3OC(═O), CH3CH2OC(═O), CH3CH2CH2OC(═O), (CH3)2CHOC(═O) and the different butoxy- or pentoxycarbonyl isomers. Examples of “alkylaminocarbonyl” include CH3NHC(═O), CH3CH2NHC(═O), CH3CH2CH2NHC(═O), (CH3)2CHNHC(═O) and the different butylamino- or pentylaminocarbonyl isomers. Examples of “dialkylaminocarbonyl” include (CH3)2NC(═O), (CH3CH2)2NC(═O), CH3CH2(CH3)NC(═O), CH3CH2CH2(CH3)NC(═O) and (CH3)2CHN(CH3)C(═O).
The total number of carbon atoms in a substituent group is indicated by the “Ci-Cj” prefix where i and j are numbers from 1 to 6. For example, C1-C3 alkylsulfonyl designates methylsulfonyl through propylsulfonyl; C2 alkoxyalkyl designates CH3OCH2; C3 alkoxyalkyl designates, for example, CH3CH(OCH3), CH3OCH2CH2 or CH3CH2OCH2; and C4 alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH3CH2CH2OCH2 and CH3CH2OCH2CH2.
In the above recitations, when a compound of Formula I is comprised of one or more heterocyclic rings, all substituents are attached to these rings through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.
When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents. Further, when the subscript indicates a range, e.g. (R)i-j, then the number of substituents may be selected from the integers between i and j inclusive.
The term “optionally substituted with one to three substituents” and the like indicates that one to three of the available positions on the group may be substituted. When a group contains a substituent which can be hydrogen, for example R1 or R5, then, when this substituent is taken as hydrogen, it is recognized that this is equivalent to said group being unsubstituted.
Compounds of this invention can exist as one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers. Accordingly, the present invention comprises compounds selected from Formula I, N-oxides and agriculturally suitable salts thereof. The compounds of the invention may be present as a mixture of stereoisomers, individual stereoisomers, or as an optically active form.
One skilled in the art will appreciate that not all nitrogen containing heterocycles can form N-oxides since the nitrogen requires an available lone pair for oxidation to the oxide; one skilled in the art will recognize those nitrogen containing heterocycles which can form N-oxides. One skilled in the art will also recognize that tertiary amines can form N-oxides. Synthetic methods for the preparation of N-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethydioxirane. These methods for the preparation of N-oxides have been extensively described and reviewed in the literature, see for example: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp 748-750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistry, vol. 3, pp 18-20, A. J. Boulton and A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keene in Advances in Heterocyclic Chemistry, vol. 43, pp 149-161, A. R. Katritzky, Ed., Academic Press; M. Tisler and B. Stanovnik in Advances in Heterocyclic Chemistry, vol. 9, pp 285-291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp 390-392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press.
The salts of the compounds of the invention include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids. The salts of the compounds of the invention also include those formed with organic bases (e.g., pyridine, ammonia, or triethylamine) or inorganic bases (e.g., hydrides, hydroxides, or carbonates of sodium, potassium, lithium, calcium, magnesium or barium) when the compound contains an acidic group such as a carboxylic acid or phenol.
As noted above, J is a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R5. The term “optionally substituted” in connection with these J groups refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. An example of phenyl optionally substituted with 1 to 4 R5 is the ring illustrated as U-1 in Exhibit 1, wherein Rv is R5 and r is an integer from 1 to 4. An example of a naphthyl group optionally substituted with 1 to 4 R5 is illustrated as U-85 in Exhibit 1, wherein Rv is R5 and r is an integer from 1 to 4. Examples of 5- or 6-membered heteroaromatic rings optionally substituted with 1 to 4 R5 include the rings U-2 through U-53 illustrated in Exhibit 1 wherein Rv is R5 and r is an integer from 1 to 4. Note that J-1 through J-13 below also denote 5- or 6-membered heteroaromatic rings. Note that U-2 through U-20 are examples of J-1, U-21 through U-35 and U-40 are examples of J-2, U-36 through U-39 are examples of J-3, U-41 through U-48 are examples of J-4 and U-49 through U-53 are examples of J-5. Note that J-6 is a subset of U-11, J-7 or J-10 are a subset of U-26, J-8 is a subset of U-42, J-9 is a subset of U-45, J-11 is a subset of U-4 and J-12 or J-13 are a subset of U-24. Also note that in J-6 through J-13 that R7 and R9 are subsets of R5. Examples of aromatic 8-, 9- or 10-membered fused heterobicyclic ring systems optionally substituted with 1 to 4 R5 include U-54 through U-84 illustrated in Exhibit 1 wherein Rv is R5 and r is an integer from 1 to 4.
Although Rv groups are shown in the structures U-1 through U-85, it is noted that they do not need to be present since they are optional substituents. Note that when Rv is H when attached to an atom, this is the same as if said atom is unsubstituted. The nitrogen atoms that require substitution to fill their valence are substituted with H or Rv. Note that some U groups can only be substituted with less than 4 Rv groups (e.g. U-14, U-15, U-18 through U-21 and U-32 through U-34 can only be substituted with one Rv). Note that when the attachment point between (Rv)r and the U group is illustrated as floating, (Rv)r can be attached to any available carbon atom of the U group. Note that when the attachment point on the U group is illustrated as floating, the U group can be attached to the remainder of Formula I through any available carbon of the U group by replacement of a hydrogen atom.
Exhibit 1






















As noted above, K is, together with the two contiguous linking carbon atoms, a 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 3 R4. Examples of said K rings wherein said rings are optionally substituted with 1 to 3 R4 include the ring systems illustrated as K-1 to K-37 in Exhibit 2, wherein n is an integer from 1 to 3 and R4 is as defined above. The term “optionally substituted” in connection with these K groups refers to K groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. As with the carbon atoms in the ring, the nitrogen atoms that require substitution to fill their valence are substituted with hydrogen or with R4. Although (R4)n groups are shown in the structures K-1 to K-37, it is noted that R4 does not need to be present since it is an optional substituent. Note that some K groups can only be substituted with less than 3 R4 groups (e.g. K-7 through K-10, K-15, K-16, K-20, K-21, K-23, K-24, K-26 and K-27 can only be substituted with one R4). In the exemplified K groups, the upper right bond is attached through the available linking carbon atom to the nitrogen atom of the NR1(=A)J portion of Formula I and the lower right bond is attached through the available linking carbon atom to the carbon atom of the C(═B)NR2R3 portion of Formula I. The wavy line indicates that the K ring is attached to the remainder of Formula I as illustrated below.




Exhibit 2













Preferred K rings include optionally substituted thiophene, isoxazole, isothiazole, pyrazole, pyridine and pyrimidine rings. More preferred K rings include K-1, K-14, K-15, K-18, K-23, K-28, K-29, K-30, K-31 and K-33. Most preferred are K-28, K-31 and K-33.
As noted above, R3 can be (among others) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, each optionally substituted with one or more substituents selected from the group consisting of a phenyl ring, or 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R6. Examples of such rings incorporated into said R3 groups include the rings illustrated as U-1 through U-53 and U-86 illustrated in Exhibit 1, except that such rings are optionally substituted with 1 to 3 substituents independently selected from R6 rather than (Rv)r and are attached to an R3 group selected from the list immediately above.
As noted above, R3 can be (among others) G, or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, each optionally substituted with G; wherein G is a 5- or 6-membered nonaromatic carbocyclic or heterocyclic ring, optionally including one or two ring members selected from the group consisting of C(═O), SO or S(O)2 and optionally substituted with 1 to 4 substituents selected from R12. The term “optionally substituted” in connection with these G groups refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. Note that when the attachment point on the G group is illustrated as floating, the G group can be attached to the remainder of Formula I through any available carbon of the G group by replacement of a hydrogen atom. The optional substituents can be attached to any available carbon by replacing a hydrogen atom. Examples of 5- or 6-membered nonaromatic carbocyclic rings as G include the rings illustrated as G-1 through G-8 of Exhibit 3. Examples of 5- or 6-membered nonaromatic heterocyclic rings as G include the rings illustrated as G-9 through G-48 of Exhibit 3. Note that when G comprises a ring selected from G-31 through G-34, G-37 and G-38, Q1 is selected from O, S or N. Note that when G is G-11, G13, G-14, G16, G-23, G-24, G-30 through G-34, G-37 and G-38 and Q1 is N, the nitrogen atom can complete its valence by substitution with either H or C1-C2 alkyl.
Exhibit 3










As noted above, each R4 can be independently (among others) a phenyl, benzyl, phenoxy or 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R6. Examples of such R4 groups include the rings or ring systems illustrated as U-1 through U-53, U-86 and U-87 illustrated in Exhibit 1, except that such rings are optionally substituted with 1 to 3 substituents independently selected from R6 rather than (Rv)r.
As noted above, each R5 can be independently (among others) a phenyl, benzyl, benzoyl, phenoxy, 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system, each ring optionally substituted with one to three substituents independently selected from R6. Examples of such R5 groups include the rings or ring systems illustrated as U-1 through U-88 illustrated in Exhibit 1, except that such rings are optionally substituted with 1 to 3 substituents independently selected from R6 rather than (Rv)r.
Preferred compounds for reasons of better activity and/or ease of synthesis are:

    
    
        Preferred 1. Compounds of Formula I above, and N-oxides and suitable salts thereof,
        
            wherein A and B are both O and J is a phenyl ring optionally substituted with 1 to 4 R5.
        
        
        Preferred 2. Compounds of Preferred 1 wherein
        
            each R4 is independently C1-C4 alkyl, C1-C4 haloalkyl, halogen, CN, NO2 or C1-C4 alkoxy, and one R4 group is attached to the K ring at the atom adjacent to either the NR1C(=A)J moiety or the C(═B)NR2R3 moiety; and
            each R5 is independently H, halogen, C1-C4 alkyl, C1-C2 alkoxy, C1-C4 haloalkyl, CN, NO2, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl or C2-C4 alkoxycarbonyl; or
            each R5 is independently a phenyl or a 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R6; or
            (R5)2 when attached to adjacent carbon atoms can be taken together as —OCF2O—, —CF2CF2O— or —OCF2CF2O—.
        
        
        Preferred 3. Compounds of Preferred 2 wherein
        
            R1 is H;
            R2 is H or CH3;
            R3 is C1-C4 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, OCH3 or S(O)pCH3;
            each R4 is independently CH3, CF3, CN or halogen, and one R4 group is attached to the K ring at the atom adjacent to the NR1C(=A)J moiety;
            each R5 is independently H, halogen, methyl, CF3, OCF3, OCHF2, S(O)pCF3, S(O)pCHF2, OCH2CF3, OCF2CHF2, S(O)pCH2CF3 or S(O)pCF2CHF2; or a phenyl, pyrazole, imidazole, triazole, pyridine or pyrimidine ring, each ring optionally substituted with one to three substituents independently selected from C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN; and
            p is 0, 1 or 2.
        
        
        Preferred 4. Compounds of Preferred 3 wherein R3 is C1-C4 alkyl.
        Preferred 5. Compounds of Formula I wherein
        
            A and B are both O;
            J is a 5- or 6-membered heteroaromatic ring selected from the group consisting of J-1, J-2, J-3, J-4 and J-5
        
        
    
    






    
    
        
        
            Q is O, S or NR5; and
            W, X, Y and Z are independently N or CR5, provided that in J-4 and J-5 at least one of W, X, Y or Z is N.
        
        
        Preferred 6. Compounds of Preferred 5 wherein
        
            each R4 is independently C1-C4 alkyl, C1-C4 haloalkyl, halogen, CN, NO2 or C1-C4 alkoxy, and one R4 group is attached to the K ring at the atom adjacent to either the NR1C(=A)J moiety or the C(═B)NR2R3 moiety; and
            each R5 is independently H, C1-C4 alkyl, C1-C4 haloalkyl, halogen, CN, NO2, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl or C2-C4 alkoxycarbonyl; or a phenyl or a 5- or 6-membered heteroaromatic ring, each ring optionally substituted with R6.
        
        
        Preferred 7. Compounds of Preferred 6 wherein
        
            J is selected from the group consisting of J-6, J-7, J-8, J-9, J-10, J-11, J-12 and J-13
        
        
    
    






    
    
        
        
            R5 is H, C1-C4 alkyl, C1-C4 haloalkyl, or
        
        
    
    






    
    
        
        
            V is N, CH, CF, CCl, CBr or CI;
            each R6 and R7 is independently H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, halogen, CN, C1-C4 alkoxy, C1-C4 haloalkoxy or C1-C4 haloalkylthio; and
            R9 is H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 alkenyl, C3-C6 haloalkenyl, C3-C6 alkynyl or C3-C6 haloalkynyl; provided R7 and R9 are not both H.
        
        
        Preferred 8. Compounds of Preferred 7 wherein V is N.
        Preferred 9. Compounds of Preferred 7 wherein V is CH, CF, CCl or CBr.
        Preferred 10. Compounds of Preferred 8 or Preferred 9 wherein
        
            R1 is H;
            R2 is H or CH3;
            R3 is C1-C4 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, OCH3 or S(O)pCH3;
            each R4 is independently CH3, CF3, CN or halogen, and one R4 group is attached to the K ring at the atom adjacent to the NR1C(=A)J moiety;
            R6 is C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN;
            R7 is H, CH3, CF3, OCH2CF3, OCHF2 or halogen; and
            p is 0, 1 or 2.
        
        
        Preferred 11. Compounds of Preferred 10 wherein R3 is C1-C4 alkyl; one R4 group is independently CH3, Cl, Br or I and is attached to the K ring at the atom adjacent to the NR1C(=A)J moiety; and a second optional R4 is H, F, Cl, Br, I or CF3.
        Preferred 12. Compounds of Preferred 11 wherein J is J-6; R6 is Cl or Br; and R7 is halogen, OCH2CF3 or CF3.
        Preferred 13. Compounds of Preferred 12 wherein V is N; R3 is methyl, ethyl, isopropyl or tertiary butyl; and R7 is Br, Cl, OCH2CF3 or CF3.
        Preferred 14. Compounds of Preferred 11 wherein J is J-7; R6 is Cl or Br; and R9 is CF3, CHF2, CH2CF3 or CF2CHF2.
        Preferred 15. Compounds of Preferred 11 wherein J is J-8; R6 is Cl or Br; and R7 is halogen, OCH2CF3 or CF3.
        Preferred 16. Compounds of Preferred 11 wherein J is J-9; R6 is Cl or Br; and R7 is OCH2CF3 or CF3.
        Preferred 17. Compounds of Preferred 11 wherein J is J-10; R6 is Cl or Br; and R9 is CF3, CHF2, CH2CF3 or CF2CHF2.
        Preferred 18. Compounds of Preferred 11 wherein J is J-11; R6 is Cl or Br; and R7 is halogen, OCH2CF3, or CF3.
        Preferred 19. Compounds of Preferred 11 wherein J is J-12; R6 is Cl or Br; R7 is H, halogen or CF3, and R9 is H, CF3, CHF2, CH2CF3, or CF2CHF2.
        Preferred 20. Compounds of Preferred 11 wherein J is J-13; R6 is Cl or Br; and R9 is H, CF3, CHF2, CH2CF3 or CF2CHF2.
    
    


Most preferred is the compound of Formula I selected from the group consisting of:

    
    
         4-[[[1-(2-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl]amino]-5-methyl-N-(1-methylethyl)-3-pyridincarboxamide,
         4-Methyl-N-(1-methylethyl)-3-[[2-methyl-4-(trifluoromethyl)benzoyl]amino]-2-thiophencarboxamide,
         1-Methyl-N-(1-methylethyl)-5-[[4-(trifluoromethyl)benzoyl]amino]-1H-pyrazole-4-carboxamide;
         4-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-5-chloro-N-methyl-3-pyridinecarboxamide;
         3-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-2,6-dichloro-N-methyl-4-pyridinecarboxamide;
         2,6-dichloro-3-[[[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl]amino]-N-(1-methylethyl)-4-pyridinecarboxamide;
         3-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-6-chloro-N,4-dimethyl-2-pyridinecarboxamide;
         3-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-4,6-dichloro-N-methyl-2-pyridinecarboxamide;
         5-[[[3-Chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-N,6-dimethyl-4-pyrimidinecarboxamide; and
         5-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-N,N,2,6-tetramethyl-4-pyridinecarboxamide.
    
    


This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt thereof and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. This invention also pertains to a composition comprising a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt thereof and an effective amount of at least one additional biologically active compound or agent. The preferred compositions of the present invention are those which comprise the above preferred compounds.
This invention also pertains to a method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt thereof (e.g., as a composition described herein). This invention also relates to such a method wherein the invertebrate pest or its environment is contacted with a biologically effective amount of a compound of Formula I or a composition comprising a compound of Formula I, an N-oxide thereof or a suitable salt thereof and a biologically effective amount of at least one additional compound or agent for controlling invertebrate pests. The preferred methods of use are those involving the above preferred compounds.
Of note are compounds of Formula 1 (a subset of Formula I) and N-oxides or suitable salts thereof




wherein

    
    
        A and B are independently O or S;
        each J is independently a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R5;
        K is, together with the two contiguous linking carbon atoms, a 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 3 R4;
        n is 1 to 3;
        R1 is H; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, each optionally substituted with one or more substituents selected from the group consisting of halogen, CN, NO2, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C2-C4 alkoxycarbonyl, C1-C4 alkylamino, C2-C8 dialkylamino and C3-C6 cycloalkylamino; or
        R1 is C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C(=A)J;
        R2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C4 alkoxy C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C2-C6 alkoxycarbonyl or C2-C6 alkylcarbonyl;
        R3 is H; G; C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, each optionally substituted with one or more substituents selected from the group consisting of halogen, G, CN, NO2, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylcarbonyl, C3-C6 trialkylsilyl, and a phenyl, phenoxy or 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from the group consisting of C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, NO2, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C4-C6 (alkyl)cycloalkylamino, C2-C4 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl and C3-C6 trialkylsilyl; C1-C4 alkoxy; C1-C4 alkylamino; C2-C8 dialkylamino; C3-C6 cycloalkylamino; C2-C6 alkoxycarbonyl or C2-C6 alkylcarbonyl; or
        R2 and R3 can be taken together with the nitrogen to which they are attached to form a ring containing 2 to 6 atoms of carbon and optionally one additional atom of nitrogen, sulfur or oxygen, said ring may be optionally substituted with 1 to 4 substituents selected from the group consisting of C1-C2 alkyl, halogen, CN, NO2 and C1-C2 alkoxy;
        G is a 5- or 6-membered nonaromatic carbocyclic or heterocyclic ring, optionally including one or two ring members selected from the group consisting of C(═O), SO or S(O)2 and optionally substituted with 1 to 4 substituents selected from the group consisting of C1-C2 alkyl, halogen, CN, NO2 and C1-C2 alkoxy;
        each R4 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, NO2, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino or C3-C6 trialkylsilyl; or
        each R4 is independently phenyl, benzyl or phenoxy, each optionally substituted with C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, NO2, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C4-C6 (alkyl)cycloalkylamino, C2-C4 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C3-C6 trialkylsilyl;
        each R5 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, CO2H, CONH2 NO2, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C3-C6 trialkylsilyl; or
        each R5 is independently a phenyl, benzyl, benzoyl, phenoxy, 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system, each ring optionally substituted with one to three substituents independently selected from the group consisting of C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, NO2, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C4-C6 (alkyl)cycloalkylamino, C2-C4 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C3-C6 trialkylsilyl; or
        (R5)2 when attached to adjacent carbon atoms can be taken together as —OCF2O—, —CF2CF2O—, or —OCF2CF2O—.
    
    


Also of note are selected compounds for reasons of cost, ease of synthesis and/or biological efficacy:

    
    
        Selection A. Compounds of Formula 1 wherein K is, together with the two linking atoms, a thiophene, pyrazole, isoxazole, pyridine or pyrimidine, optionally substituted with 1 to 3 R4.
        Selection B. Compounds of Selection A wherein J is independently a phenyl ring or a 5- or 6-membered heteroaromatic ring wherein each ring is optionally substituted with 1 to 2 R5.
        Selection C. Compounds of Selection A wherein
        
            J is a phenyl ring or a 5- or 6-membered heteroaromatic ring selected from the group consisting of J-1, J-2, J-3, J-4 and J-5
        
        
    
    






    
    
        
        
            Q is O, S or NR5; and
            W, X, Y and Z are independently N or CR5, provided that in J-4 and J-5 at least one of W, X, Y or Z is N.
        
        
        Selection D. Compounds of Selection B or Selection C wherein
        
            A and B are both O;
            n is 1 to 2;
            R1 is H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, C2-C6 alkylcarbonyl or C2-C6 alkoxycarbonyl;
            R2 is H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, C2-C6 alkylcarbonyl or C2-C6 alkoxycarbonyl;
            R3 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, each optionally substituted with one or more substituents selected from the group consisting of halogen, CN, C1-C2 alkoxy, C1-C2 alkylthio, C1-C2 alkylsulfinyl and C1-C2 alkylsulfonyl;
        
        
        one of the R4 groups is attached to the heteroaromatic ring at one of the two positions ortho to the two linking atoms, and said R4 is C1-C4 alkyl, C1-C4 haloalkyl, halogen, CN, NO2, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl or C1-C4 haloalkylsulfonyl;
        each R5 is independently H, C1-C4 alkyl, C1-C4 haloalkyl, halogen, CN, NO2, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl or C2-C4 alkoxycarbonyl; or a phenyl or a 5- or 6-membered heteroaromatic ring, each ring optionally substituted with C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C3-C6 halocycloalkyl, halogen, CN, NO2, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C4-C6 (alkyl)cycloalkylamino, C2-C4 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C3-C6 trialkylsilyl; or
        
            (R5)2 when attached to adjacent carbon atoms can be taken together as —OCF2O—, —CF2CF2O— or —OCF2CF2O—.
        
        
        Selection E. Compounds of Selection D wherein
        
            J is selected from the group consisting of phenyl, pyridine, pyrimidine, pyrazole, imidazole, triazole, thiophene, thiazole and oxazole, furan, isothiazole and isoxazole, each optionally substituted with 1 to 2 R5.
        
        
        Selection F. Compounds of Selection E wherein
        
            J is selected from the group consisting of phenyl, pyridine, pyrimidine, pyrazole, thiophene and thiazole, each optionally substituted with 1 to 2 R5;
            R1 and R2 are both H;
            R3 is C1-C4 alkyl optionally substituted with halogen, CN, OCH3, S(O)pCH3;
            each R4 is independently CH3, CF3, OCF3, OCHF2, S(O)pCF3, S(O)pCHF2, CN or halogen;
            each R5 is independently H, halogen, CH3, CF3, OCHF2, S(O)pCF3, S(O)pCHF2, OCH2CF3, OCF2CHF2, S(O)pCH2CF3, S(O)pCF2CHF2; or phenyl, pyrazole, imidazole, triazole, pyridine or pyrimidine, each ring optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, halogen or CN; and
            p is 0, 1 or 2.
        
        
        Selection G. Compounds of Selection F wherein R3 is C1-C4 alkyl.
        Selection H. Compounds of Selection G wherein J is a phenyl optionally substituted with 1 to 2 R5.
        Selection I. Compounds of Selection H wherein one R5 is a phenyl optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
        Selection J. Compounds of Selection H wherein one R5 is a pyrazole, imidazole, triazole, pyridine or pyrimidine, each ring optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
        Selection K. Compounds of Selection I wherein J is a pyridine optionally substituted with 1 to 2 R5.
        Selection L. Compounds of Selection K wherein one R5 is a phenyl optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
        Selection M. Compounds of Selection K wherein one R5 is a pyrazole, imidazole, triazole, pyridine or pyrimidine, each ring optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
        Selection N. Compounds of Selection I wherein J is a pyrimidine optionally substituted with 1 to 2 R5.
        Selection O. Compounds of Selection N wherein one R5 is a phenyl optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
        Selection P. Compounds of Selection N wherein one R5 is a pyrazole, imidazole, triazole, pyridine or pyrimidine, each ring optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
        Selection Q. Compounds of Selection I wherein J is a pyrazole optionally substituted with 1 to 2 R5.
        Selection R. Compounds of Selection Q wherein one R5 is a phenyl optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
        Selection S. Compounds of Selection Q wherein one R5 is a pyrazole, imidazole, triazole, pyridine or pyrimidine, each ring optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
        Selection T. Compounds of Selection S wherein one R5 is a pyridine optionally substituted with C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN.
    
    


Most select is the compound of Formula 1 selected from the group consisting of:

    
    
        4-[[[1-(2-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl]amino]-5-methyl-N-(1-methylethyl)-3-pyridincarboxamide,
        4-Methyl-N-(1-methylethyl)-3-[[2-methyl-4-(trifluoromethyl)benzoyl]amino]-2-thiophencarboxamide, and
        1-Methyl-N-(1-methylethyl)-5-[[4-(trifluoromethyl)benzoyl]amino]-1H-pyrazole-4-carboxamide.
    
    


The compounds of Formula I can be prepared by one or more of the following methods and variations as described in Schemes 1-19. The definitions of A, B, J, K, R1, R2, R3, R4, R5 and n in the compounds of Formulae I and 2-41 below are as defined above in the Summary of the Invention. Compounds of Formulae Ia-c, 2a-b and 4a-g are various subsets of the compounds of Formula I, 2 and 4, respectively. Of note are compounds of Formulae I, 2, 5, 6, 6a, 13, 14, 15, 40 and 41 wherein K is selected from the group consisting of optionally substituted thiophene, isoxazole, isothiazole, pyrazole, pyridine and pyrimidine rings. Also of note are compounds of Formulae I, 2, 5, 6, 6a, 13, 14, 15, 40 and 41 wherein K is K-1, K-14, K-15, K-18, K-23, K-28, K-29, K-30, K-31 and K-33. Of particular note are compounds of Formulae I, 2, 5, 6, 6a, 13, 14, 15, 40 and 41 wherein K is K-28, K-31 and K-33.
Compounds of Formula I can be prepared by procedures outlined in Schemes 1-19. A typical procedure is detailed in Scheme 1 and involves coupling of an ortho amino carboxylic acid amide of Formula 2 with an acid chloride of Formula 3 in the presence of an acid scavenger to provide the compound of Formula Ia. Typical acid scavengers include amine bases such as triethylamine, diisopropylethylamine and pyridine; other scavengers include hydroxides such as sodium and potassium hydroxide and carbonates such as sodium carbonate and potassium carbonate. In certain instances it is useful to use polymer-supported acid scavengers such as polymer-bound diisopropylethylamine and polymer-bound dimethylaminopyridine. In a subsequent step, amides of Formula Ia can be converted to thioamides of Formula Ib using a variety of standard thio transfer reagents including phosphorus pentasulfide and Lawesson's reagent.




An alternate procedure for the preparation of compounds of Formula Ia involves coupling of an amide of Formula 2 with an acid of Formula 4 in the presence of a dehydrating agent such as dicyclohexylcarbodiimide (DCC). Polymer supported reagents are useful here, such as polymer-bound cyclohexylcarbodiimide. Synthetic procedures of Schemes 1 and 2 are only representative examples of useful methods for the preparation of Formula I compounds as the synthetic literature is extensive for this type of reaction.




One skilled in the art will also realize that acid chlorides of Formula 3 may be prepared from acids of Formula 4 by numerous well-known methods.
An alternate procedure for the preparation of compounds of Formula Ia involves coupling of an ortho amino carboxylic acid ester of Formula 5 with an acid chloride of Formula 3 by a method similar to that described in Scheme 1, followed by transformation of the ester group into an amide functionality. This transformation can be achieved by an amination with an amine of Formula 7. A Lewis acid such as trimethylaluminum as shown in Scheme 3 may catalyze this reaction.




Alternatively the ester 6 can be transformed to an amide (6a) as shown in Scheme 4 by saponification with a base such as aqueous sodium hydroxide followed by dehydrative coupling with an amine of Formula 7 by a procedure similar to that described in Scheme 2.




Benzoic acids of Formula 4 (J is optionally substituted phenyl) are generally well known in the art as are procedures for their preparation. One particularly useful subset of benzoic acids of this invention are 2-methyl-4-perfluoroalkyl benzoic acids of Formula 4a (R5(a) equals e.g. CF3, C2F5, C3F7). The synthesis for these compounds is outlined in Schemes 5-9. Benzoic acids of Formula 4a may be prepared from the benzonitriles of Formula 8 by hydrolysis. The conditions used may involve the use of a base such as an alkaline metal hydroxide or alkoxide (e.g. potassium or sodium hydroxide) in a solvent such as water, ethanol or ethylene glycol (e.g. J. Chem. Soc. 1948, 1025). Alternatively, the hydrolysis may be carried out using an acid such as sulfuric acid or phosphoric acid in a suitable solvent such as water (e.g. Org. Synth. 1955, Coll. vol. 3, 557). The choice of the conditions is contingent on the stability of R5 to the reaction conditions and elevated temperatures are usually employed to achieve this transformation.




Nitriles of Formula 8 may be prepared from anilines of Formula 9 by the classical sequence involving diazotization and treatment of the intermediate diazonium salt with a copper cyanide salt (e.g. J. Amer. Chem. Soc. 1902, 24, 1035).




Anilines of Formula 9 may be prepared from compounds of Formula 10. This transformation may be achieved by a well-known procedure that employs Raney Nickel (Org. Synth. Coll. Vol. VI, 581). Alternatively, the same transformation may be effected by the use of a suitable catalyst such as palladium in the presence of hydrogen. The reaction is usually conducted at pressures of 104 to 107 kPa in a suitable organic solvent such as, but not limited to, toluene. Elevated temperatures of 80-110° C. are usually required to achieve the transformation. As one skilled in the art will realize, numerous chemical modifications of the thioether moiety are possible, and may be employed when necessary to facilitate this transformation.




Compounds of Formula 10 may be prepared from iminosulfuranes of Formula 11. The transformation may be achieved in a protic solvent such as methanol or water, in a non-protic solvent such as dichloromethane or toluene in the presence of a suitable base such as triethylamine (e.g. Org. Synth. Coll. Vol. VI, 581) or sodium methoxide, or in a combination of a protic solvent, a protic solvent and a base. The temperature at which the reaction is conducted is usually in the range 40-110° C. As one skilled in the art will realize, suitable salts of compounds of Formula 11 such as, but not limited to a hydrochloride, a sulfate or a bisulfate may also be employed, provided that the appropriate amount of base is first used to generate the free base 11. This may be done as a separate step or as an integral part of the step involving the transformation of compounds of Formula 11 to compounds of Formula 10.




Compounds of Formula 11 may be prepared from anilines of Formula 12 by reaction with dimethyl sulfide and a suitable chlorinating agent such as, but not limited to N-chlorosuccinimide (e.g. Org. Synth. Coll. Vol. VI, 581), chlorine or N-chlorobenzotriazole. Alternatively, anilines of Formula 12 may be treated with dimethyl sulfoxide which has been “activated” by treatment with an agent such as acetic anhydride, trifluoroacetic, anhydride, trifluoromethanesulfonic anhydride, cyclohexylcarbodiimide, sulfur trioxide, or phosphorus pentoxide. The reaction is conducted in a suitable organic solvent such as dichloromethane or dimethyl sulfoxide. The reaction is conducted at a temperature of −70° C. to 25° C. and is dependent on the solvent and reagent used.




Intermediate ortho amino carboxylic acid amides of Formula 2a and 2b may also be prepared from isatoic anhydrides of Formula 13 and 14 (Scheme 10). Typical procedures involve combination of equimolar amounts of the amine 7 with the isatoic anhydride in polar aprotic solvents such as pyridine and dimethylformamide at temperatures ranging from room temperature to 100° C. R1 substituents such as alkyl and substituted alkyl may be introduced by the base catalyzed alkylation of isatoic anhydride 13 with known alkylating reagents R1-Lg (wherein Lg is a leaving group such as halogen, alkyl or aryl suphonates or alkyl sulfates) to provide the alkyl substituted intermediates 14. Isatoic anhydrides of Formula 13 may be made by methods described in Coppola, Synthesis 1980, 505 and Fabis et al Tetrahedron, 1998, 10789.




An alternate procedure for the preparation of specific compounds of Formula I (wherein A is O, B is O and R1 is H) involves reaction of an amine 7 with a heterocyclic fused oxazinone of Formula 15. Typical procedures involve combination of the amine with the oxazinone in solvents such as tetrahydrofuran or pyridine at temperatures ranging from room temperature to the reflux temperature of the solvent. Oxazinones are well documented in the chemical literature and are available via known methods that involve the coupling of either an ortho amino carboxylic acid with an acid chloride. For references to the synthesis and chemistry of heterocyclic fused oxazinones see Jakobsen et al, Biorganic and Medicinal Chemistry, 2000, 8, 2803-2812 and references cited therein.




Heterocyclic acids of Formula 4, wherein J is an optionally substituted heterocycle, can be prepared by procedures outlined in Schemes 12-17. Both general and specific references to a wide variety of heterocyclic acids including thiophenes, furans, pyridines, pyrimidines, triazoles, imidazoles, pyrazoles, thiazoles, oxazoles, isothiazoles, thiadiazoles, oxadiazoles, triazines, pyrazines, pyridazines, and isoxazoles can be found in the following compendia: Rodd's Chemistry of Chemistry of Carbon Compounds, Vol. IVa to IVl., S. Coffey editor, Elsevier Scientific Publishing, New York, 1973; Comprehensive Heterocyclic Chemistry, Vol. 1-7, A. R. Katritzky and C. W. Rees editors, Pergamon Press, New York, 1984; Comprehensive Heterocyclic Chemistry II, Vol. 1-9, A. R. Katritzky, C. W. Rees, and E. F. Scriven editors, Pergamon Press, New York, 1996; and the series, The Chemistry of Heterocyclic Compounds, E. C. Taylor, editor, Wiley, New York. Particularly useful heterocyclic acids of this invention include pyridine acids, pyrimidine acids and pyrazole acids. Procedures for the synthesis of representative examples of each are detailed in Schemes 12-17. A variety of heterocyclic acids and general methods for their synthesis may be found in World Patent Application WO 98/57397.
The synthesis of representative pyridine acids (4b) is depicted in Scheme 12. This procedure involves the known synthesis of pyridines from β-ketoesters and 4-aminobutenones (19). Substituent groups R5(a) and R5(b) include e.g. alkyl and haloalkyl.




The synthesis of representative pyrimidine acids (4c) is depicted in Scheme 13. This procedure involves the known synthesis of pyrimidines from vinylidene-β-ketoesters (22) and amidines. Substituent groups R5(a) and R5(b) include e.g. alkyl and haloalkyl.




The synthesis of representative pyrazole acids (4d-4g) is depicted in Schemes 14-17. Pyrazoles 4d are described in Scheme 14. The synthesis of Scheme 14 involves as the key step introduction of the R5(b) substituent via alkylation of the pyrazole. The alkylating agent R5(b)-Lg (wherein Lg is a leaving group such as Cl, Br, I, sulfonates such as p-toluenesulfonate or methanesulfonate or sulfates such as —SO2OR7(b)) includes R7(b) groups such as C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C3-C8 dialkylaminocarbonyl, C3-C6 trialkylsilyl; or phenyl, benzyl, benzoyl, 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system, each ring or ring system optionally substituted. Oxidation of the methyl group affords the pyrazole carboxylic acid. Some of the more preferred R5(a) groups include haloalkyl.




Pyrazoles 4e are described in Scheme 15. These pyrazole acids may be prepared via metallation and carboxylation of pyrazoles of formula 28 as the key step. The R5(b) group is introduced in a manner similar to that of Scheme 14, i.e. via alkylation with a R5(b) alkylating agent. Representative R5(a) groups include e.g. cyano, and haloalkyl.




Pyrazoles 4f are described in Scheme 16. These can be prepared via reaction of an optionally substituted phenyl hydrazine 29 with a pyruvate 30 to yield pyrazole esters 31. Hydrolysis of the ester affords the pyrazole acids 4f. This procedure is particularly useful for the preparation of compounds where R5(b) is optionally substituted phenyl and R5(a) is haloalkyl.




Pyrazoles acids of Formula 4g are described in Scheme 17. These can be prepared via 3+2 cycloaddition of an appropriately substituted nitrilimine (32) with either substituted propiolates (33) or acrylates (36). Cycloaddition with acrylates requires additional oxidation of the intermediate pyrazoline to the pyrazole. Hydrolysis of the ester affords the pyrazole acids 4g. Preferred iminohalides for this reaction include the trifluoromethyl iminochloride (38) and the iminodibromide (39). Compounds such as 38 are known (J. Heterocycl. Chem. 1985, 22(2), 565-8). Compounds such as 39 are available by known methods (Tetrahedron Letters 1999, 40, 2605). These procedures are particularly useful for the preparation of compounds where R5(b) is optionally substituted phenyl and R5(a) is haloalkyl or bromo.




Ortho-amino carboxylic acid esters of Formula 5 wherein R1 is H can be prepared from monoesters of ortho dicarboxylic acids of Formula 40 via rearrangement of the corresponding acyl azide and hydrolysis of the resulting isocyanate (or alternatively by trapping of the isocyanate with an alcohol and cleaving of the resulting carbamate) as shown in Scheme 18.




Alternatively ortho-amino carboxylic acid esters of Formula 5 can be prepared from ortho carboxamide carboxylic esters of Formula 41 by Hoffman rearrangement with reagents such as sodium hydroxide and bromine as shown in Scheme 19.




Compounds of Formulae 40 and41 are known in the art or can be readily prepared from compounds known in the art. (For example, see Tetrahedron, 1997, 53, 14497; J. Chem. Soc., Perkin Trans. 1, 1996, 10, 1035; WO92/08724 and EP 418667).
It is recognized that some reagents and reaction conditions described above for preparing compounds of Formula I may not be compatible with certain functionalities present in the intermediates. In these instances, the incorporation of protection/deprotection sequences or functional group interconversions into the synthesis will aid in obtaining the desired products. The use and choice of the protecting groups will be apparent to one skilled in chemical synthesis (see, for example, Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 2nd ed.; Wiley: New York, 1991). One skilled in the art will recognize that, in some cases, after the introduction of a given reagent as it is depicted in any individual scheme, it may be necessary to perform additional routine synthetic steps not described in detail to complete the synthesis of compounds of Formula I. One skilled in the art will also recognize that it may be necessary to perform a combination of the steps illustrated in the above schemes in an order other than that implied by the particular sequence presented to prepare the compounds of Formula I.
One skilled in the art will also recognize that compounds of Formula I and the intermediates described herein can be subjected to various electrophilic, nucleophilic, radical, organometallic, oxidation, and reduction reactions to add substituents or modify existing substituents.
Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting of the disclosure in any way whatsoever. Percentages are by weight except for chromatographic solvent mixtures or where otherwise indicated. Parts and percentages for chromatographic solvent mixtures are by volume unless otherwise indicated. 1H NMR spectra are reported in ppm downfield from tetramethylsilane; s is singlet, d is doublet, t is triplet, q is quartet, m is multiplet, dd is doublet of doublets, dt is doublet of triplets, brs is broad singlet.


EXAMPLE 1
Preparation of 5-methyl-N-(1-methylethyl)-4-[[4-trifluoromethoxy)benzoyl]amino]-3-pyridinecarboxamide
Step A: Preparation of ethyl 4-azido-5-methyl-3-pyridinecarboxylate
A slurry of 14.1 g (78 mmol) of ethyl 1,4-dihydro-5-methyl-4oxo-3-pyridinecarboxylate (prepared according to Horvath, G.; Dvortsak, P. J. Heterocycl. Chem. 1980, 359) in 30 mL of phosphorous oxychloride was refluxed for 1 hour. After cooling, the volatiles were removed with a rotary evaporator. The residue was poured into cold saturated aqueous sodium bicarbonate. Dichloromethane was added and the mixture was filtered through celite. The layers were separated. The organic layer was dried (sodium sulfate) and the solvent was removed with a rotary evaporator. The residue was dissolved in 150 mL of dimethylformamide. 15.2 g (234 mmol) of sodium azide was added. The mixture was heated at 95° C. for 1 hour. After cooling, the solvent was removed with a rotary evaporator. The residue was partitioned between ethyl acetate and water. The organic layer was dried (sodium sulfate) and the solvent was removed with a rotary evaporator. The residue was passed through a plug of silica gel with 25% ethyl acetate in hexanes as eluant to afford 11.9 g of the title compound as a cream colored solid.
1H NMR (CDCl3) δ 1.41 (t, 3H), 2.12 (s, 3H), 4.36 (q, 2H), 8.12 (s, 1H), 8.83 (s, 1H).
Step B: Preparation of ethyl 4-amino-5-methyl-3-pyridinecarboxylate
0.50 g of material prepared in Step A was dissolved in 15 mL of ethanol. 0.15 g of 10% palladium on carbon was added. The reaction mixture was placed under one atmosphere of hydrogen for 2 hours. The catalyst was removed by filtration. The solvent was removed with a rotary evaporator to afford 0.43 g of the title compound as a white solid.
1H NMR (CDCl3) δ 1.42 (t, 3H), 2.30 (s, 3H), 4.45 (q, 2H), 8.47 (s, 1H), 8.87 (s, 1H).
Step C: Preparation of ethyl 5-methyl-4-[[4-trifluoromethoxy)benzoyl]amino]-3-pyridinecarboxylate
1.0 g (5.6 mmol) of material prepared in Step B was dissolved in 30 mL of dichloromethane. 0.77 mL (5.6 mmol) of triethylamine, a catalytic amount of 4-dimethylaminopyridine and 0.88 mL (5.6 mmol) of 4-(trifluoromethoxy)benzoyl chloride were added. The mixture was stirred overnight. The reaction mixture was washed with water. The organic layer was dried (sodium sulfate) and the solvent was removed with a rotary evaporator. The residue was purified by medium-pressure liquid chromatography (MPLC) with a gradient of 15-100% ethyl acetate in hexanes as eluant. The bisacylation product eluted first, then 0.42 g of the title compound as white solid. Starting material (0.52 g) was also recovered.
1H NMR (CDCl3) δ 1.41 (t, 3H), 2.32 (s, 3H), 4.39 (q, 2H), 7.37 (d, 2H), 8.08 (d, 2H), 8.63 (brs, 1H), 9.04 (brs, 1H), 10.78 (brs, 1H).
Step D: Preparation of 5-methyl-N-(1-methylethyl)-4-[[4-trifluoromethoxy)benzoyl]amino]-3-pyridinecarboxamide
To a solution of 0.049 mL (0.57 mmol) of isopropylamine in 20 mL of dichloroethane at 0° C. was added 0.64 mL (1.3 mmol) of a 2M solution of trimethylaluminum in toluene dropwise. A solution of 0.21 g (0.57 mmol) of the material prepared in Step C in 5 mL of dichloroethane was added dropwise. Four days later an additional 0.049 mL of isopropylamine and 0.64 mL of trimethylaluminum were added. The reaction was refluxed for 6 h. After cooling 20 mL of 1 N HCl was added. The layers were separated. The aqueous layer was made basic with a saturated sodium bicarbonate solution. Dichloromethane was added and the mixture was filtered through celite. The dichloromethane was separated, combined with the dichloroethane layer from above and dried (sodium sulfate). The solvent was removed with a rotary evaporator. The residue was purified by MPLC with a gradient of 25-50% ethyl acetate in hexanes as eluant to afford 0.047 g of the title compound, a compound of the invention, as a white solid; m.p. 202-204° C.
1H NMR (CDCl3) δ 1.27 (d, 6H), 2.33 (s, 3H), 4.23 (m, 1H), 6.46 (br, 1H), 7.35 (d, 2H), 8.07 (d, 2H), 8.56 (brs, 1H), 8.69 (brs, 1H), 11.15 (brs, 1H).
EXAMPLE 2
Preparation of 1-methyl-N-(1-methylethyl)-5-[[4-trifluoromethoxy)benzoyl]amino]-1H-pyrazole-4-carboxamide
Step A: Preparation of 5-amino-1-methyl-N-(1-methylethyl)-1H-pyrazole-4-carboxamide
1.0 g (8.0 mmol) of 2-cyano-N-(1-methylethyl)acetamide (prepared according to the procedure of Cheikh et al J. Org. Chem., 1991, 56, 970) was combined with 3.1 mL of triethylorthoformate, 5 mL of acetic anhydride and 0.01 g of anhydrous zinc chloride. The mixture was refluxed for 1 hour. A distillation head was placed on the flask and the reaction was heated at 120° C. for 8 hours. After standing for two days the mixture was heated again for 12 hours at 120° C. for 12 hours. The volatiles were removed with a rotary evaporator. Ethanol was added and the volatiles were again removed with a rotary evaporator. This material was dissolved in 15 mL of ethanol. 0.34 mL (6.4 mmol) of methyl hydrazine was added. The reaction mixture was refluxed for 5 hours and then allowed to stand at room temperature overnight. The solvent was removed with a rotary evaporator. The residue was purified by MPLC (ethyl acetate as eluant) to afford 0.14 g of the title compound as a solid.
1H NMR (CDCl3) δ 1.23 (d, 6H), 3.61 (s, 3H), 4.21 (m, 1H), 5.17 (br, 2H), 5.34 (br, 1H), 7.38 (s, 1H).
Step B: Preparation of 1-methyl-N-(1-methylethyl)-5-[[4-trifluoromethoxy)benzoyl]amino]-1H-pyrazole-4-carboxamide
0.14 g (0.77 mmol) of the material from Step A was dissolved in 20 mL of tetrahydrofuran and 0.12 mL (0.85 mmol) of triethylamine and 0.12 mL (0.77 mmol) of 4-(trifluoromethoxy)benzoyl chloride were added. Three days later 0.12 mL (0.85 mmol) of triethylamine and 0.12 mL (0.77 mmol) of 4-(trifluoromethoxy)benzoyl chloride were added. The reaction mixture was refluxed for two days. After cooling the reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried (sodium sulfate) and the solvent was removed with a rotary evaporator. The residue was purified by MPLC with 50% ethyl acetate in hexanes as eluant to afford 0.18 g of the tidle compound, a compound of the invention, as a white solid; m.p. 68-75° C.
1H NMR (CDCl3) δ 1.22 (d, 6H), 3.91 (s, 3H), 4.14 (m, 1H), 5.92 (brd, 1H), 7.32 (d, 2H), 7.62 (s, 1H), 8.08 (d, 2H), 10.78 (brs, 1H).
EXAMPLE 3
Preparation of 4-methyl-N-(1-methylethyl)-3-[[4-trifluoromethyl)benzoyl]amino]-2-thiophenecarboxamide
Step A: Preparation of 7-methyl-2H-thieno[3,2-d][1,3]oxazine-2,4(1H)-dione
Phosgene in toluene (4.4 g, 20%, 8.88 mmol) was added to the sodium salt of 3-amino-4-methyl-thiophene-2-carbocyclic acid (1 g, 5.58 mmol) in water (17 mL) at 0 C. The mixture was allowed to warm to room temperature and was stirred for 1 hour. The mixture was filtered. After drying in vacuum the product was obtained as a solid 0.49 g (47%).
IR (Nujol®) 1785, 1696, 1580, 1513, 1236, 988, 918, 848, 826 cm-1.
1H NMR (DMSO-d6) δ 2.20 (s, 3H), 7.88 (s, 1H).
Step B: Preparation of 7-methyl-2-[4-(trifluoromethyl)phenyl]-4H-thieno[3,2-d][1,3]oxazin-4-one
4-(Dimethylamino)pyridine (0.66 g, 5.41 mmol) was added to the product from Step A in dioxane (10 mL). 4-(Trifluoromethyl)benzoyl chloride (1.13 g, 5.42 mmol) was added to the mixture and the mixture was boiled for approximately 3 hours. The mixture was allowed to cool to room temperature and was poured into hydrochloric acid (100 mL, 1 N). The mixture was extracted with ethyl acetate (3×50 mL) and the combined extracts were dried and evaporated. Chromatography on silicon gel (eluted with ethyl acetate/hexanes) gave the product as a white solid 1.56 g, (91.7%).
IR (Nujol®) 2923, 1763, 1600, 1572, 1410, 1312, 1234, 1170, 1125, 1068, 1013, 978, 934, 851, 813 cm-1.
1H NMR (CDCl3) δ 2.47 (s, 3H), 7.60 (s, 1H), 7.77 (d, 2H), 8.45(d, 2H).
Step C: Preparation of 4-methyl-N-(1-methylethyl)-3-[[4-trifluoromethyl)benzoyl]amino]-2-thiophenecarboxamide
A mixture of the product from Step B (0.2 g, 0.043 mmol) and isopropylamine (0.2 g, 3.39 mmol) in THF (5 mL) was stirred for 6 hours. The solvent was removed under reduced pressure to give the product, a compound of the invention, as a solid 0.21 g, (91%).
IR (Nujol®) 3294, 1664, 1625, 1573, 1524, 1409, 1327, 1207, 1167 1126, 1068, 1018, 954, 885, 857 cm-1.
1H NMR (CDCl3) δ 1.22 (d, 6H), 2.30 (s, 3H), 4.22-4.11 (m, 1H), 5.58 (d, 1H), 7.03 (s, 1H), 7.75 (d, 2H), 8.13 (d, 2H), 10.63 (5,1H).
EXAMPLE 4
Preparation of 5-[[[3-Chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-N,6-dimethyl-4-pyrimidinecarboxamide
Step A: Preparation of 1-(1,1-dimethylethyl 4-ethyl-2-acetyl-3-amino-2-butenedioate
To a mixture of 17.15 g (108 mmol) of t-butyl acetoacetate and 12.8 mL (130 mmol) of ethyl cyanoformate in 25 mL of dichloromethane was added 1.64 g of zinc acetylacetonate hydrate. After stirring overnight the volatiles were removed with a rotary evaporator. The residue was dissolved in ethyl acetate and filtered through celite. The solvent was removed with a rotary evaporator to afford 29.9 g of the title compound as a white solid as an E/Z isomer mixture.
1H NMR (CDCl3) δ 1.33 (t, 3H), 1.52 (s, 9H), 2.35 (s, 3H) [minor isomer 2.40 (s, 3H)], 4.33 (m, 2H).
Step B: Preparation of 5-(1,1-dimethylethyl) hydrogen 6-methyl-4,5-pyrimidinedicarboxylate
To a solution of 11.6 g (45 mmol) of the material from Step A in 55 mL of ethanol was added 10.9 g (135 mmol) of formamidine hydrochloride. The reaction mixture was cooled in an ice bath and 17 mL (135 mmol) of 1,1,3,3-tetramethylguanidine was added dropwise. After the mixture was stirred overnight the solvent was removed with a rotary evaporator. The residue was partitioned between ethyl acetate and water. The aqueous layer was cooled in an ice bath, acidified with concentrated HCl and extracted three times with ethyl acetate. The organic layer was dried (sodium sulfate) and the solvent was removed with a rotary evaporator to afford 9.12 g of the title compound as a yellow solid.
1H NMR (CDCl3) δ 1.65 (s, 9H), 2.68 (s, 3H), 9.19 (s, 1H).
Step C: Preparation of 5-(1,1-dimethylethyl) 4-methyl 6-methyl-4,5-pyrimidinedicarboxylate
To a solution of 9.12 g (38 mmol) of the material from Step B in 100 mL of N,N-dimethyl formamide (DMF) was added 3.1 mL (50 mmol) of iodomethane and 3.7 g (50 mmol) of lithium carbonate. The reaction mixture was heated at 60° C. for 3 hours. After cooling the reaction mixture was partitioned between dichloromethane and water. The organic layer was dried (sodium sulfate) and the solvent was removed with a rotary evaporator and then a vacuum pump. The residue was purified by MPLC with a gradient of 20-30% ethyl acetate in hexanes as eluant to afford 7.58 g of the title compound as an off-white solid.
1H NMR (CDCl3) δ 1.63 (s, 9H), 2.67 (s, 3H), 4.01 (s, 3H), 9.19 (s, 1H).
Step D: Preparation of methyl 5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-methyl-4-pyrimidinecarboxamide
7.55 g of the material from Step C was dissolved in 40 mL of dichloromethane. 20 mL of trifluoroacetic acid was added. After two days the reaction mixture was refluxed for 6 hours. After an additional day the volatiles were removed with a rotary evaporator. Toluene was added and the solvent was removed with a rotary evaporator. This material (9.2 g) was dissolved in 100 mL of t-butanol. 9.2 mL (66 mmol) of triethylamine and 14 mL (66 mmol) of diphenylphosphoryl azide were added. The reaction was refluxed 3 hours. After cooling, the solvent was removed with a rotary evaporator. The residue was partitioned between ethyl acetate and water. The organic layer was dried (sodium sulfate) and the solvent was removed with a rotary evaporator. The residue was purified by MPLC with a gradient of 40-100% ethyl acetate in hexanes as eluant to afford 5.81 g of the title compound as a yellow solid.
1H NMR (CDCl3) δ 1.52 (s, 9H), 2.60 (s, 3H), 4.03 (s, 3H), 8.07 (br, 1H),8.98 (s, 1H).
Step E: Preparation of methyl 5-amino-6-methyl-4-pyrimidinecarboxylate
5.8 g of the material from Step D was dissolved in 25 mL of trifluoroacetic acid. After stirring for 90 minutes the solvent was removed with a rotary evaporator. Saturated aqueous sodium bicarbonate was added. The aqueous layer was extracted five times with dichloromethane. The organic layer was dried (sodium sulfate) and the solvent was removed with a rotary evaporator to afford 3.78 g of the title compound with a small amount of an impurity.
1H NMR (CDCl3) δ 2.50 (s, 3H), 4.00 (s, 3H), 5.76 (br, 2H),8.56 (s, 1H).
Step F: Preparation of 5-amino-6-methyl-4-pyrimidinecarboxylic acid monosodium salt
2.0 g (12 mmol) of the material from Step E was dissolved in 24 mL of methanol. 12 mL of 1N solution of sodium hydroxide was added. After 1 hour the solvent was removed with a rotary evaporator. The residue was dried in a vacuum oven overnight to afford 2.39 g of the title compound as a tan solid.
1H NMR (D2O) δ 2.45 (s, 3H), 8.37 (s, 1H).
Step G: Preparation of 3-chloro-N,N-dimethyl-1H-pyrazole-1-sulfonamide
To a solution of N-dimethylsulfamoylpyrazole (188.0 g, 1.07 mol) in dry tetrahydrofuran (1500 mL) at −78° C. was added dropwise a solution of 2.5 M n-butyl-lithium (472 mL, 1.18 mol) in hexane while maintaining the temperature below −65° C. Upon completion of the addition the reaction mixture was maintained at −78° C. for an additional 45 minutes, after which time a solution of hexachloroethane (279 g, 1.18 mol) in tetrahydrofuran (120 mL) was added dropwise. The reaction mixture was maintained for an hour at −78° C., warmed to −20° C. and then quenched with water (1 L). The reaction mixture was extracted with methylene chloride (4×500 mL); the organic extracts were dried over magnesium sulfate and concentrated. The crude product was further purified by chromatography on silica gel using methylene chloride as eluent to afford the title product compound as a yellow oil (160 g).
1H NMR (CDCl3) δ 3.07 (d, 6H), 6.33 (s, 1H), 7.61 (s, 1H).
Step H: Preparation of 3-chloropyrazole
To trifluoroacetic acid (290 mL) was added dropwise the chloropyrazole product (160 g) from Step G, and the reaction mixture was stirred at room temperature for 1.5 hours and then concentrated at reduced pressure. The residue was taken up in hexane, insoluble solids were filtered off, and the hexane was concentrated to afford the crude product as an oil. The crude product was further purified by chromatography on silica gel using ether/hexane (40:60) as eluent to afford the title product as a yellow oil (64.44 g).
1H NMR (CDCl3) δ 6.39 (s, 1H), 7.66 (s, 1H), 9.6 (br s, 1H).
Step I: Preparation of 3-chloro-2-(3-chloro-1H-pyrazol-1-yl)pyridine
To a mixture of 2,3-dichloropyridine (92.60 g, 0.629 mol) and 3-chloropyrazole (64.44 g, 0.629 mol) in N,N-dimethylformamide (400 mL) was added potassium carbonate (147.78 g, 1.06 mol), and the reaction mixture was then heated to 100° C. for 36 hours. The reaction mixture was cooled to room temperature and slowly poured into ice water. The precipitated solids were filtered and washed with water. The solid filter cake was taken up in ethyl acetate, dried over magnesium sulfate and concentrated. The crude solid was chromatographed on silica gel using 20% ethyl acetate/hexane as eluent to afford the title product as a white solid (39.75 g).
1H NMR (CDCl3) δ 6.43 (s, 1H), 7.26 (m, 1H), 7.90 (d, 1H), 8.09 (s, 1H), 8.41 (d, 11H).
Step J: Preparation of 3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
To a solution of the pyrazole product from Step I (39.75 g, 186 mmol) in dry tetrahydrofuran (400 mL) at −78° C. was added dropwise a solution of 2.0 M lithium diisopropylamide (93 mL, 186 mmol) in tetrahydrofuran. Carbon dioxide was bubbled through the amber solution for 14 minutes, after which time the solution became pale brownish-yellow. The reaction was made basic with 1N aqueous sodium hydroxide solution and extracted with ether (2×500 mL). The aqueous extracts were acidified with 6N hydrochloric acid and extracted with ethyl acetate (3×500 mL). The ethyl acetate extracts were dried over magnesium sulfate and concentrated to afford the title product as an off-white white solid (42.96 g). (Product from another run following similar procedure melted at 198-199° C.)
1H NMR (DMSO-d6) δ 6.99 (s, 1H), 7.45 (m, 1H), 7.93 (d, 1H), 8.51 (d, 1H).
Step K: Preparation of 2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-pyrimido[5,4-d][1,3]oxazin-4-one
To a solution of 0.26 mL (3.3 mmol) of methanesulfonyl chloride in 18 mL of acetonitrile at 0° C. was added 0.77 g (3.0 mmol) of 3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-carboxylic acid from Step J. 0.42 mL (3.0 mmol) of triethylamine in 9 mL of acetonitrile was added dropwise. After 20 minutes at 0° C., 0.525 g (3.0 mmol) of material from Step F was added. After 15 minutes 0.42 mL (3.0 mmol) of triethylamine was added dropwise. After 2 hours 0.26 mL (3.3 mmol) of methanesulfonyl chloride was added. After stirring overnight. The reaction mixture was poured into water. Filtration afforded 0.27 g of the title compound.
1H NMR (CDCl3) δ 2.20 (s, 3H), 7.23 (s, 1H), 7.54(dd, 1H), 8.01 (dd, 1H), 8.57(dd, 1H), 9.20 (s, 1H).
Step L: Preparation of 5-[[[3-Chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-N,6-dimethyl-4-pyrimidinecarboxamide
2 mL of a 2M solution of methylamine in tetrahydrofuran was added to 0.090 g of material from Step K. After stirring overnight the solvent was removed with a rotary evaporator to afford 0.071 g of the title compound, a compound of the invention, as a tan solid; m.p. 205-207° C.
1H NMR (CDCl3) δ 2.48 (s, 3H), 3.04 (d, 3H), 7.06 (s, 1H), 7.41(dd, 1H), 7.89 (dd, 1H), 8.30 (br, 1H), 8.48 (dd, 1H), 8.85 (s, 1H), 11.57 (br, 1H).
EXAMPLE 5
Preparation of 2,6-dichloro-3-[[[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl ]carbonyl]amino]-N-(1-methylethyl)-4-pyridinecarboxamide
Step A: Preparation of ethyl 3-amino-4-pyridinecarboxylate
To a solution of 1 g (7.25 mmol) of 3-amino-4-pyridinecarboxylic acid in 5 mL of ethyl alcohol was added 2 mL of sulfuric acid. The mixture was warmed under reflux for 2 h. It was cooled and basified with conc. NH4OH solution to pH=8. The resulting solution was extracted with ethyl acetate and the organic layer was washed with brine and water, dried (MgSO4) and concentrated in vacuo to give 1.04 g of the title compound as a white solid (87%).
1H NMR (CDCl3) δ 8.19 (s 1H), 7.93 (d 1H, J is 5.1 Hz), 7.60 (d, 1H, J is 5.1 Hz), 5.67 (br s, 2H), 4.36 (q, 2H), 1.40 (t, 3H).
Step B: Preparation of ethyl 3-amino-2,6-dichloro-4-pyridinecarboxylate
To a solution of 1.04 g (6.27 mmol) of ethyl 3-amino-4-pyridinecarboxylate in 5 mL of DMF was added 1.67 g of N-chlorosuccinimide (12.5 mmol) in a single portion at room temperature. The mixture was then stirred at the same temperature for 24 hours. The resulting mixture was concentrated in vacuo and purified by silica gel column to give 1.40 g of the title compound as a white solid (95%).
1H NMR (CDCl3) δ 7.67 (s 1H), 6.18 (br s, 2H), 4.39 (q, 2H), 1.42 (t, 3H).
Step C: Preparation of 3-amino-2,6-dichloro-4-pyridinecarboxylic monopotassium salt
To a solution of 1.30 g (5.54 mmol) of ethyl 3-amino-2,6-dichloro-4-pyridinecarboxylate in a mixture of 5 mL of water and 20 mL of ethyl alcohol was added 622 mg (11.1 mmol) of potassium hydroxide at room temperature and the reaction mixture was warmed at 90° C. for 1 hour. The mixture was then concentrated in vacuo and evaporated with benzene three times to give 1.63 g of the title compound as a white solid. The crude product was used in the next reaction without any further purification (98%).
1H NMR (DMSOd-6) δ 7.31 (s, 1H), 7.14 (br s, 2H).
Step D: Preparation of 6,8-dichloro-2H-pyrido[3,4-d][1,3]oxazine-2,4(1H)-dione
To a solution of 1.64 g (5.54 mmol) of the material from Step C in 20 mL of dioxane was added 2.2 g (11.1 mmol) of diphosgene at 0° C. The mixture was allowed to warm to room temperature and stirred for 24 hours. The mixture was then concentrated in vacuo to give 1.70 g of the title compound as a white solid (quantitative).
1H NMR (DMSOd-6) δ 7.99 (s, 1H).
Step E: Preparation of 3-chloro-2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine
To a mixture of 2,3-dichloropyridine (99.0 g, 0.67 mol) and 3-trifluoromethyl pyrazole (83 g, 0.61 mol) in dry N,N-dimethylformamide (300 mL) was added potassium carbonate (166.0 g, 1.2 mol) and the reaction was then heated to 110-125 ° C. over 48 hours. The reaction was cooled to 100° C. and filtered through Celite® diatomaceous filter aid to remove solids. N,N-Dimethylformamide and excess dichloropyridine were removed by distillation at atmospheric pressure. Distillation of the product at reduced pressure (b.p. 139-141° C., 7 mm) afforded the desired intermediate as a clear yellow oil (113.4 g).
1H NMR (CDCl3) δ 6.78 (s, 1H), 7.36 (t, 1H), 7.93 (d, 1H), 8.15 (s, 1H), 8.45 (d, 1H).
Step F: Preparation of 1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
To a solution of the pyrazole product from Step E (105.0 g, 425 mmol) in dry tetrahydrofuran (700 mL) at −75° C. was added via cannula a −30° C. solution of lithium diisopropylamide (425 mmol) in dry tetrahydrofuran (300 mL). The deep red solution was stirred for 15 minutes, after which time carbon dioxide was bubbled through at −63° C. until the solution became pale yellow and the exothermicity ceased. The reaction was stirred for an additional 20 minutes and then quenched with water (20 mL). The solvent was removed under reduced pressure, and the reaction mixture partitioned between ether and 0.5 N aqueous sodium hydroxide solution. The aqueous extracts were washed with ether (3×), filtered through Celite® diatomaceous filter aid to remove residual solids, and then acidified to a pH of approximately 4, at which point an orange oil formed. The aqueous mixture was stirred vigorously and additional acid was added to lower the pH to 2.5-3. The orange oil congealed into a granular solid, which was filtered, washed successively with water and 1N hydrochloric acid, and dried under vacuum at 50° C. to afford the title product as an off-white solid (130 g). (Product from another run following similar procedure melted at 175-176° C.)
1H NMR (DMSO-d6) δ 7.61 (s, 1H), 7.76 (dd, 1H), 8.31 (d, 1H), 8.60 (d, 1H).
Step G: Preparation of 2,6-dichloro-3-[[[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl]amino]-N-(1-methylethyl)-4-pyridinecarboxamide
To a solution of 268 mg (0.92 mmol) of 1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (from Step F) in 5 mL of dichloromethane was added 160 μL (1.84 mmol) of oxalyl chloride and two drops of DMF in sequence at room temperature. The mixture was then stirred at the same temperature for 1 hour. The crude mixture was then concentrated in vacuo. The resulting mixture was dissolved with 5 mL of acetonitrile followed by additions of 280 mg (0.92 mmol) of the compound prepared in Step D and 298 μL (3.68 mmol) of pyridine in sequence. The reaction mixture was warmed to 70° C. for 2 hours and allowed to cool to room temperature. A solution of 157 μL (1.84 mmol) of isopropylamine in 1 mL of acetonitrile was added to the mixture and it was warmed to 60° C. for 1 hour. The reaction was allowed to cool to room temperature and quenched with water. The aqueous layer was extracted with ethyl acetate and the organic layer was dried with MgSO4 and concentrated in vacuo. The resulting mixture was purified with a silica gel column to give 250 mg of the title compound, a compound of the invention, as a white solid (52%). m.p. 240-242° C.
1H NMR (CDCl3) δ 9.85 (s, 1H), 8.53 (dd, 1H), 7.90 (dd, 1H), 7.56 (s, 1H), 7.42 (dd, 1H), 7.22 (s, 1H), 6.08 (br d, 1H), 4.13 (m, 1H), 1.14 (d, 6H).
By the procedures described herein together with methods known in the art, the following compounds of Tables 1 to 32 can be prepared. The following abbreviations are used in the Tables: t is tertiary, s is secondary, n is normal, i is iso, c is cyclo, Me is methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, t-Bu is tertiary butyl, Ph is phenyl, OMe is methoxy, OEt is ethoxy, SMe is methylthio, SEt is ethylthio, CN is cyano, NO2 is nitro, TMS is trimethylsilyl, S(O)Me is methylsulfinyl, and S(O)2Me is methylsulfonyl. Structures of K for Tables 15, 16 and 17 can be found in Exhibit 2.







TABLE 1













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


Cl
2-CF3
Cl
3-CF3
Cl
4-CF3


Cl
2-OCF3
Cl
3-OCF3
Cl
4-OCF3


Cl
2-OCF2H
Cl
3-OCF2H
Cl
4-OCF2H


Cl
2-OCF2CF2H
Cl
3-OCF2CF2H
Cl
4-OCF2CF2H


Cl
2-OCH2CF3
Cl
3-OCH2CF3
Cl
4-OCH2CF3


Cl
2-SCF3
Cl
3-SCF3
Cl
4-SCF3


Cl
2-SOCF3
Cl
3-SOCF3
Cl
4-SOCF3


Cl
2-SO2CF3
Cl
3-SO2CF3
Cl
4-SO2CF3


Cl
2-SCF2H
Cl
3-SCF2H
Cl
4-SCF2H


Cl
2-SOCF2H
Cl
3-SOCF2H
Cl
4-SOCF2H


Cl
2-SO2CF2H
Cl
3-SO2CF2H
Cl
4-SO2CF2H


F
2-CF3
F
3-CF3
F
4-CF3


F
2-OCF3
F
3-OCF3
F
4-OCF3


F
2-OCF2H
F
3-OCF2H
F
4-OCF2H


F
2-OCF2CF2H
F
3-OCF2CF2H
F
4-OCF2CF2H


F
2-OCH2CF3
F
3-OCH2CF3
F
4-OCH2CF3


F
2-SCF3
F
3-SCF3
F
4-SCF3


F
2-SOCF3
F
3-SOCF3
F
4-SOCF3


F
2-SO2CF3
F
3-SO2CF3
F
4-SO2CF3


F
2-SCF2H
F
3-SCF2H
F
4-SCF2H


F
2-SOCF2H
F
3-SOCF2H
F
4-SOCF2H


F
2-SO2CF2H
F
3-SO2CF2H
F
4-SO2CF2H


Br
2-CF3
Br
3-CF3
Br
4-CF3


Br
2-OCF3
Br
3-OCF3
Br
4-OCF3


Br
2-OCF2H
Br
3-OCF2H
Br
4-OCF2H


Br
2-OCF2CF2H
Br
3-OCF2CF2H
Br
4-OCF2CF2H


Br
2-OCH2CF3
Br
3-OCH2CF3
Br
4-OCH2CF3


Br
2-SCF3
Br
3-SCF3
Br
4-SCF3


Br
2-SOCF3
Br
3-SOCF3
Br
4-SOCF3


Br
2-SO2CF3
Br
3-SO2CF3
Br
4-SO2CF3


Br
2-SCF2H
Br
3-SCF2H
Br
4-SCF2H


Br
2-SOCF2H
Br
3-SOCF2H
Br
4-SOCF2H


Br
2-SO2CF2H
Br
3-SO2CF2H
Br
4-SO2CF2H


I
2-CF3
I
3-CF3
I
4-CF3


I
2-OCF3
I
3-OCF3
I
4-OCF3


I
2-OCF2H
I
3-OCF2H
I
4-OCF2H


I
2-OCF2CF2H
I
3-OCF2CF2H
I
4-OCF2CF2H


I
2-OCH2CF3
I
3-OCH2CF3
I
4-OCH2CF3


I
2-SCF3
I
3-SCF3
I
4-SCF3


I
2-SOCF3
I
3-SOCF3
I
4-SOCF3


I
2-SO2CF3
I
3-SO2CF3
I
4-SO2CF3


I
2-SCF2H
I
3-SCF2H
I
4-SCF2H


I
2-SOCF2H
I
3-SOCF2H
I
4-SOCF2H


I
2-SO2CF2H
I
3-SO2CF2H
I
4-SO2CF2H


OMe
2-CF3
OMe
3-CF3
OMe
4-CF3


OMe
2-OCF3
OMe
3-OCF3
OMe
4-OCF3


OMe
2-OCF2H
OMe
3-OCF2H
OMe
4-OCF2H


OMe
2-OCF2CF2H
OMe
3-OCF2CF2H
OMe
4-OCF2CF2H


OMe
2-OCH2CF3
OMe
3-OCH2CF3
OMe
4-OCH2CF3


OMe
2-SCF3
OMe
3-SCF3
OMe
4-SCF3


OMe
2-SOCF3
OMe
3-SOCF3
OMe
4-SOCF3


OMe
2-SO2CF3
OMe
3-SO2CF3
OMe
4-SO2CF3


OMe
2-SCF2H
OMe
3-SCF2H
OMe
4-SCF2H


OMe
2-SOCF2H
OMe
3-SOCF2H
OMe
4-SOCF2H


OMe
2-SO2CF2H
OMe
3-SO2CF2H
OMe
4-SO2CF2H


CF3
2-CF3
CF3
3-CF3
CF3
4-CF3


CF3
2-OCF3
CF3
3-OCF3
CF3
4-OCF3


CF3
2-OCF2H
CF3
3-OCF2H
CF3
4-OCF2H


CF3
2-OCF2CF2H
CF3
3-OCF2CF2H
CF3
4-OCF2CF2H


CF3
2-OCH2CF3
CF3
3-OCH2CF3
CF3
4-OCH2CF3


CF3
2-SCF3
CF3
3-SCF3
CF3
4-SCF3


CF3
2-SOCF3
CF3
3-SOCF3
CF3
4-SOCF3


CF3
2-SO2CF3
CF3
3-SO2CF3
CF3
4-SO2CF3


CF3
2-SCF2H
CF3
3-SCF2H
CF3
4-SCF2H


CF3
2-SOCF2H
CF3
3-SOCF2H
CF3
4-SOCF2H


CF3
2-SO2CF2H
CF3
3-SO2CF2H
CF3
4-SO2CF2H


OCF2H
2-CF3
OCF2H
3-CF3
OCF2H
4-CF3


OCF2H
2-OCF3
OCF2H
3-OCF3
OCF2H
4-OCF3


OCF2H
2-OCF2H
OCF2H
3-OCF2H
OCF2H
4-OCF2H


OCF2H
2-OCF2CF2H
OCF2H
3-OCF2CF2H
OCF2H
4-OCF2CF2H


OCF2H
2-OCH2CF3
OCF2H
3-OCH2CF3
OCF2H
4-OCH2CF3


OCF2H
2-SCF3
OCF2H
3-SCF3
OCF2H
4-SCF3


OCF2H
2-SOCF3
OCF2H
3-SOCF3
OCF2H
4-SOCF3


OCF2H
2-SO2CF3
OCF2H
3-SO2CF3
OCF2H
4-SO2CF3


OCF2H
2-SCF2H
OCF2H
3-SCF2H
OCF2H
4-SCF2H


OCF2H
2-SOCF2H
OCF2H
3-SOCF2H
OCF2H
4-SOCF2H


OCF2H
2-SO2CF2H
OCF2H
3-SO2CF2H
OCF2H
4-SO2CF2H


Me
2-Me-4-CF3
F
2-Me-4-CF3
Cl
2-Me-4-CF3


Me
2-Me-4-OCF3
F
2-Me-4-OCF3
Cl
2-Me-4-OCF3


Me
2-Me-4-OCF2H
F
2-Me-4-OCF2H
Cl
2-Me-4-OCF2H


Me
2-Me-4-OCH2CF3
F
2-Me-4-OCH2CF3
Cl
2-Me-4-OCH2CF3


Me
2-Me-4-SCF3
F
2-Me-4-SCF3
Cl
2-Me-4-SCF3


Me
2-Me-4-SOCF3
F
2-Me-4-SOCF3
Cl
2-Me-4-SOCF3


Me
2-Me-4-SO2CF3
F
2-Me-4-SO2CF3
Cl
2-Me-4-SO2CF3


Me
2-Me-4-SCF2H
F
2-Me-4-SCF2H
Cl
2-Me-4-SCF2H


Me
2-Me-4-SOCF2H
F
2-Me-4-SOCF2H
Cl
2-Me-4-SOCF2H


Me
2-Me-4-SO2CF2H
F
2-Me-4-SO2CF2H
Cl
2-Me-4-SO2CF2H


Br
2-Me-4-CF3
I
2-Me-4-CF3
OMe
2-Me-4-CF3


Br
2-Me-4-OCF3
I
2-Me-4-OCF3
OMe
2-Me-4-OCF3


Br
2-Me-4-OCF2H
I
2-Me-4-OCF2H
OMe
2-Me-4-OCF2H


Br
2-Me-4-OCH2CF3
I
2-Me-4-OCH2CF3
OMe
2-Me-4-OCH2CF3


Br
2-Me-4-SCF3
I
2-Me-4-SCF3
OMe
2-Me-4-SCF3


Br
2-Me-4-SOCF3
I
2-Me-4-SOCF3
OMe
2-Me-4-SOCF3


Br
2-Me-4-SO2CF3
I
2-Me-4-SO2CF3
OMe
2-Me-4-SO2CF3


Br
2-Me-4-SCF2H
I
2-Me-4-SCF2H
OMe
2-Me-4-SCF2H


Br
2-Me-4-SOCF2H
I
2-Me-4-SOCF2H
OMe
2-Me-4-SOCF2H


Br
2-Me-4-SO2CF2H
I
2-Me-4-SO2CF2H
OMe
2-Me-4-SO2CF2H


CF3
2-Me-4-CF3
NO2
2-Me-4-CF3
SMe
2-Me-4-CF3


CF3
2-Me-4-OCF3
NO2
2-Me-4-OCF3
SMe
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
NO2
2-Me-4-OCF2H
SMe
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
NO2
2-Me-4-OCH2CF3
SMe
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
NO2
2-Me-4-SCF3
SMe
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
NO2
2-Me-4-SOCF3
SMe
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
NO2
2-Me-4-SO2CF3
SMe
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
NO2
2-Me-4-SCF2H
SMe
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
NO2
2-Me-4-SOCF2H
SMe
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
NO2
2-Me-4-SO2CF2H
SMe
2-Me-4-SO2CF2H
















TABLE 2













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


Cl
2-CF3
Cl
3-CF3
Cl
4-CF3


Cl
2-OCF3
Cl
3-OCF3
Cl
4-OCF3


Cl
2-OCF2H
Cl
3-OCF2H
Cl
4-OCF2H


Cl
2-OCF2CF2H
Cl
3-OCF2CF2H
Cl
4-OCF2CF2H


Cl
2-OCH2CF3
Cl
3-OCH2CF3
Cl
4-OCH2CF3


Cl
2-SCF3
Cl
3-SCF3
Cl
4-SCF3


Cl
2-SOCF3
Cl
3-SOCF3
Cl
4-SOCF3


Cl
2-SO2CF3
Cl
3-SO2CF3
Cl
4-SO2CF3


Cl
2-SCF2H
Cl
3-SCF2H
Cl
4-SCF2H


Cl
2-SOCF2H
Cl
3-SOCF2H
Cl
4-SOCF2H


Cl
2-SO2CF2H
Cl
3-SO2CF2H
Cl
4-SO2CF2H


F
2-CF3
F
3-CF3
F
4-CF3


F
2-OCF3
F
3-OCF3
F
4-OCF3


F
2-OCF2H
F
3-OCF2H
F
4-OCF2H


F
2-OCF2CF2H
F
3-OCF2CF2H
F
4-OCF2CF2H


F
2-OCH2CF3
F
3-OCH2CF3
F
4-OCH2CF3


F
2-SCF3
F
3-SCF3
F
4-SCF3


F
2-SOCF3
F
3-SOCF3
F
4-SOCF3


F
2-SO2CF3
F
3-SO2CF3
F
4-SO2CF3


F
2-SCF2H
F
3-SCF2H
F
4-SCF2H


F
2-SOCF2H
F
3-SOCF2H
F
4-SOCF2H


F
2-SO2CF2H
F
3-SO2CF2H
F
4-SO2CF2H


Br
2-CF3
Br
3-CF3
Br
4-CF3


Br
2-OCF3
Br
3-OCF3
Br
4-OCF3


Br
2-OCF2H
Br
3-OCF2H
Br
4-OCF2H


Br
2-OCF2CF2H
Br
3-OCF2CF2H
Br
4-OCF2CF2H


Br
2-OCH2CF3
Br
3-OCH2CF3
Br
4-OCH2CF3


Br
2-SCF3
Br
3-SCF3
Br
4-SCF3


Br
2-SOCF3
Br
3-SOCF3
Br
4-SOCF3


Br
2-SO2CF3
Br
3-SO2CF3
Br
4-SO2CF3


Br
2-SCF2H
Br
3-SCF2H
Br
4-SCF2H


Br
2-SOCF2H
Br
3-SOCF2H
Br
4-SOCF2H


Br
2-SO2CF2H
Br
3-SO2CF2H
Br
4-SO2CF2H


I
2-CF3
I
3-CF3
I
4-CF3


I
2-OCF3
I
3-OCF3
I
4-OCF3


I
2-OCF2H
I
3-OCF2H
I
4-OCF2H


I
2-OCF2CF2H
I
3-OCF2CF2H
I
4-OCF2CF2H


I
2-OCH2CF3
I
3-OCH2CF3
I
4-OCH2CF3


I
2-SCF3
I
3-SCF3
I
4-SCF3


I
2-SOCF3
I
3-SOCF3
I
4-SOCF3


I
2-SO2CF3
I
3-SO2CF3
I
4-SO2CF3


I
2-SCF2H
I
3-SCF2H
I
4-SCF2H


I
2-SOCF2H
I
3-SOCF2H
I
4-SOCF2H


I
2-SO2CF2H
I
3-SO2CF2H
I
4-SO2CF2H


OMe
2-CF3
OMe
3-CF3
OMe
4-CF3


OMe
2-OCF3
OMe
3-OCF3
OMe
4-OCF3


OMe
2-OCF2H
OMe
3-OCF2H
OMe
4-OCF2H


OMe
2-OCF2CF2H
OMe
3-OCF2CF2H
OMe
4-OCF2CF2H


OMe
2-OCH2CF3
OMe
3-OCH2CF3
OMe
4-OCH2CF3


OMe
2-SCF3
OMe
3-SCF3
OMe
4-SCF3


OMe
2-SOCF3
OMe
3-SOCF3
OMe
4-SOCF3


OMe
2-SO2CF3
OMe
3-SO2CF3
OMe
4-SO2CF3


OMe
2-SCF2H
OMe
3-SCF2H
OMe
4-SCF2H


OMe
2-SOCF2H
OMe
3-SOCF2H
OMe
4-SOCF2H


OMe
2-SO2CF2H
OMe
3-SO2CF2H
OMe
4-SO2CF2H


CF3
2-CF3
CF3
3-CF3
CF3
4-CF3


CF3
2-OCF3
CF3
3-OCF3
CF3
4-OCF3


CF3
2-OCF2H
CF3
3-OCF2H
CF3
4-OCF2H


CF3
2-OCF2CF2H
CF3
3-OCF2CF2H
CF3
4-OCF2CF2H


CF3
2-OCH2CF3
CF3
3-OCH2CF3
CF3
4-OCH2CF3


CF3
2-SCF3
CF3
3-SCF3
CF3
4-SCF3


CF3
2-SOCF3
CF3
3-SOCF3
CF3
4-SOCF3


CF3
2-SO2CF3
CF3
3-SO2CF3
CF3
4-SO2CF3


CF3
2-SCF2H
CF3
3-SCF2H
CF3
4-SCF2H


CF3
2-SOCF2H
CF3
3-SOCF2H
CF3
4-SOCF2H


CF3
2-SO2CF2H
CF3
3-SO2CF2H
CF3
4-SO2CF2H


OCF2H
2-CF3
OCF2H
3-CF3
OCF2H
4-CF3


OCF2H
2-OCF3
OCF2H
3-OCF3
OCF2H
4-OCF3


OCF2H
2-OCF2H
OCF2H
3-OCF2H
OCF2H
4-OCF2H


OCF2H
2-OCF2CF2H
OCF2H
3-OCF2CF2H
OCF2H
4-OCF2CF2H


OCF2H
2-OCH2CF3
OCF2H
3-OCH2CF3
OCF2H
4-OCH2CF3


OCF2H
2-SCF3
OCF2H
3-SCF3
OCF2H
4-SCF3


OCF2H
2-SOCF3
OCF2H
3-SOCF3
OCF2H
4-SOCF3


OCF2H
2-SO2CF3
OCF2H
3-SO2CF3
OCF2H
4-SO2CF3


OCF2H
2-SCF2H
OCF2H
3-SCF2H
OCF2H
4-SCF2H


OCF2H
2-SOCF2H
OCF2H
3-SOCF2H
OCF2H
4-SOCF2H


OCF2H
2-SO2CF2H
OCF2H
3-SO2CF2H
OCF2H
4-SO2CF2H


Me
2-Me-4-CF3
F
2-Me-4-CF3
Cl
2-Me-4-CF3


Me
2-Me-4-OCF3
F
2-Me-4-OCF3
Cl
2-Me-4-OCF3


Me
2-Me-4-OCF2H
F
2-Me-4-OCF2H
Cl
2-Me-4-OCF2H


Me
2-Me-4-OCH2CF3
F
2-Me-4-OCH2CF3
Cl
2-Me-4-OCH2CF3


Me
2-Me-4-SCF3
F
2-Me-4-SCF3
Cl
2-Me-4-SCF3


Me
2-Me-4-SOCF3
F
2-Me-4-SOCF3
Cl
2-Me-4-SOCF3


Me
2-Me-4-SO2CF3
F
2-Me-4-SO2CF3
Cl
2-Me-4-SO2CF3


Me
2-Me-4-SCF2H
F
2-Me-4-SCF2H
Cl
2-Me-4-SCF2H


Me
2-Me-4-SOCF2H
F
2-Me-4-SOCF2H
Cl
2-Me-4-SOCF2H


Me
2-Me-4-SO2CF2H
F
2-Me-4-SO2CF2H
Cl
2-Me-4-SO2CF2H


Br
2-Me-4-CF3
I
2-Me-4-CF3
OMe
2-Me-4-CF3


Br
2-Me-4-OCF3
I
2-Me-4-OCF3
OMe
2-Me-4-OCF3


Br
2-Me-4-OCF2H
I
2-Me-4-OCF2H
OMe
2-Me-4-OCF2H


Br
2-Me-4-OCH2CF3
I
2-Me-4-OCH2CF3
OMe
2-Me-4-OCH2CF3


Br
2-Me-4-SCF3
I
2-Me-4-SCF3
OMe
2-Me-4-SCF3


Br
2-Me-4-SOCF3
I
2-Me-4-SOCF3
OMe
2-Me-4-SOCF3


Br
2-Me-4-SO2CF3
I
2-Me-4-SO2CF3
OMe
2-Me-4-SO2CF3


Br
2-Me-4-SCF2H
I
2-Me-4-SCF2H
OMe
2-Me-4-SCF2H


Br
2-Me-4-SOCF2H
I
2-Me-4-SOCF2H
OMe
2-Me-4-SOCF2H


Br
2-Me-4-SO2CF2H
I
2-Me-4-SO2CF2H
OMe
2-Me-4-SO2CF2H


CF3
2-Me-4-CF3
NO2
2-Me-4-CF3
SMe
2-Me-4-CF3


CF3
2-Me-4-OCF3
NO2
2-Me-4-OCF3
SMe
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
NO2
2-Me-4-OCF2H
SMe
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
NO2
2-Me-4-OCH2CF3
SMe
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
NO2
2-Me-4-SCF3
SMe
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
NO2
2-Me-4-SOCF3
SMe
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
NO2
2-Me-4-SO2CF3
SMe
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
NO2
2-Me-4-SCF2H
SMe
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
NO2
2-Me-4-SOCF2H
SMe
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
NO2
2-Me-4-SO2CF2H
SMe
2-Me-4-SO2CF2H
















TABLE 3













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


Cl
2-CF3
Cl
3-CF3
Cl
4-CF3


Cl
2-OCF3
Cl
3-OCF3
Cl
4-OCF3


Cl
2-OCF2H
Cl
3-OCF2H
Cl
4-OCF2H


Cl
2-OCF2CF2H
Cl
3-OCF2CF2H
Cl
4-OCF2CF2H


Cl
2-OCH2CF3
Cl
3-OCH2CF3
Cl
4-OCH2CF3


Cl
2-SCF3
Cl
3-SCF3
Cl
4-SCF3


Cl
2-SOCF3
Cl
3-SOCF3
Cl
4-SOCF3


Cl
2-SO2CF3
Cl
3-SO2CF3
Cl
4-SO2CF3


Cl
2-SCF2H
Cl
3-SCF2H
Cl
4-SCF2H


Cl
2-SOCF2H
Cl
3-SOCF2H
Cl
4-SOCF2H


Cl
2-SO2CF2H
Cl
3-SO2CF2H
Cl
4-SO2CF2H


F
2-CF3
F
3-CF3
F
4-CF3


F
2-OCF3
F
3-OCF3
F
4-OCF3


F
2-OCF2H
F
3-OCF2H
F
4-OCF2H


F
2-OCF2CF2H
F
3-OCF2CF2H
F
4-OCF2CF2H


F
2-OCH2CF3
F
3-OCH2CF3
F
4-OCH2CF3


F
2-SCF3
F
3-SCF3
F
4-SCF3


F
2-SOCF3
F
3-SOCF3
F
4-SOCF3


F
2-SO2CF3
F
3-SO2CF3
F
4-SO2CF3


F
2-SCF2H
F
3-SCF2H
F
4-SCF2H


F
2-SOCF2H
F
3-SOCF2H
F
4-SOCF2H


F
2-SO2CF2H
F
3-SO2CF2H
F
4-SO2CF2H


Br
2-CF3
Br
3-CF3
Br
4-CF3


Br
2-OCF3
Br
3-OCF3
Br
4-OCF3


Br
2-OCF2H
Br
3-OCF2H
Br
4-OCF2H


Br
2-OCF2CF2H
Br
3-OCF2CF2H
Br
4-OCF2CF2H


Br
2-OCH2CF3
Br
3-OCH2CF3
Br
4-OCH2CF3


Br
2-SCF3
Br
3-SCF3
Br
4-SCF3


Br
2-SOCF3
Br
3-SOCF3
Br
4-SOCF3


Br
2-SO2CF3
Br
3-SO2CF3
Br
4-SO2CF3


Br
2-SCF2H
Br
3-SCF2H
Br
4-SCF2H


Br
2-SOCF2H
Br
3-SOCF2H
Br
4-SOCF2H


Br
2-SO2CF2H
Br
3-SO2CF2H
Br
4-SO2CF2H


I
2-CF3
I
3-CF3
I
4-CF3


I
2-OCF3
I
3-OCF3
I
4-OCF3


I
2-OCF2H
I
3-OCF2H
I
4-OCF2H


I
2-OCF2CF2H
I
3-OCF2CF2H
I
4-OCF2CF2H


I
2-OCH2CF3
I
3-OCH2CF3
I
4-OCH2CF3


I
2-SCF3
I
3-SCF3
I
4-SCF3


I
2-SOCF3
I
3-SOCF3
I
4-SOCF3


I
2-SO2CF3
I
3-SO2CF3
I
4-SO2CF3


I
2-SCF2H
I
3-SCF2H
I
4-SCF2H


I
2-SOCF2H
I
3-SOCF2H
I
4-SOCF2H


I
2-SO2CF2H
I
3-SO2CF2H
I
4-SO2CF2H


OMe
2-CF3
OMe
3-CF3
OMe
4-CF3


OMe
2-OCF3
OMe
3-OCF3
OMe
4-OCF3


OMe
2-OCF2H
OMe
3-OCF2H
OMe
4-OCF2H


OMe
2-OCF2CF2H
OMe
3-OCF2CF2H
OMe
4-OCF2CF2H


OMe
2-OCH2CF3
OMe
3-OCH2CF3
OMe
4-OCH2CF3


OMe
2-SCF3
OMe
3-SCF3
OMe
4-SCF3


OMe
2-SOCF3
OMe
3-SOCF3
OMe
4-SOCF3


OMe
2-SO2CF3
OMe
3-SO2CF3
OMe
4-SO2CF3


OMe
2-SCF2H
OMe
3-SCF2H
OMe
4-SCF2H


OMe
2-SOCF2H
OMe
3-SOCF2H
OMe
4-SOCF2H


OMe
2-SO2CF2H
OMe
3-SO2CF2H
OMe
4-SO2CF2H


CF3
2-CF3
CF3
3-CF3
CF3
4-CF3


CF3
2-OCF3
CF3
3-OCF3
CF3
4-OCF3


CF3
2-OCF2H
CF3
3-OCF2H
CF3
4-OCF2H


CF3
2-OCF2CF2H
CF3
3-OCF2CF2H
CF3
4-OCF2CF2H


CF3
2-OCH2CF3
CF3
3-OCH2CF3
CF3
4-OCH2CF3


CF3
2-SCF3
CF3
3-SCF3
CF3
4-SCF3


CF3
2-SOCF3
CF3
3-SOCF3
CF3
4-SOCF3


CF3
2-SO2CF3
CF3
3-SO2CF3
CF3
4-SO2CF3


CF3
2-SCF2H
CF3
3-SCF2H
CF3
4-SCF2H


CF3
2-SOCF2H
CF3
3-SOCF2H
CF3
4-SOCF2H


CF3
2-SO2CF2H
CF3
3-SO2CF2H
CF3
4-SO2CF2H


OCF2H
2-CF3
OCF2H
3-CF3
OCF2H
4-CF3


OCF2H
2-OCF3
OCF2H
3-OCF3
OCF2H
4-OCF3


OCF2H
2-OCF2H
OCF2H
3-OCF2H
OCF2H
4-OCF2H


OCF2H
2-OCF2CF2H
OCF2H
3-OCF2CF2H
OCF2H
4-OCF2CF2H


OCF2H
2-OCH2CF3
OCF2H
3-OCH2CF3
OCF2H
4-OCH2CF3


OCF2H
2-SCF3
OCF2H
3-SCF3
OCF2H
4-SCF3


OCF2H
2-SOCF3
OCF2H
3-SOCF3
OCF2H
4-SOCF3


OCF2H
2-SO2CF3
OCF2H
3-SO2CF3
OCF2H
4-SO2CF3


OCF2H
2-SCF2H
OCF2H
3-SCF2H
OCF2H
4-SCF2H


OCF2H
2-SOCF2H
OCF2H
3-SOCF2H
OCF2H
4-SOCF2H


OCF2H
2-SO2CF2H
OCF2H
3-SO2CF2H
OCF2H
4-SO2CF2H


Me
2-Me-4-CF3
F
2-Me-4-CF3
Cl
2-Me-4-CF3


Me
2-Me-4-OCF3
F
2-Me-4-OCF3
Cl
2-Me-4-OCF3


Me
2-Me-4-OCF2H
F
2-Me-4-OCF2H
Cl
2-Me-4-OCF2H


Me
2-Me-4-OCH2CF3
F
2-Me-4-OCH2CF3
Cl
2-Me-4-OCH2CF3


Me
2-Me-4-SCF3
F
2-Me-4-SCF3
Cl
2-Me-4-SCF3


Me
2-Me-4-SOCF3
F
2-Me-4-SOCF3
Cl
2-Me-4-SOCF3


Me
2-Me-4-SO2CF3
F
2-Me-4-SO2CF3
Cl
2-Me-4-SO2CF3


Me
2-Me-4-SCF2H
F
2-Me-4-SCF2H
Cl
2-Me-4-SCF2H


Me
2-Me-4-SOCF2H
F
2-Me-4-SOCF2H
Cl
2-Me-4-SOCF2H


Me
2-Me-4-SO2CF2H
F
2-Me-4-SO2CF2H
Cl
2-Me-4-SO2CF2H


Br
2-Me-4-CF3
I
2-Me-4-CF3
OMe
2-Me-4-CF3


Br
2-Me-4-OCF3
I
2-Me-4-OCF3
OMe
2-Me-4-OCF3


Br
2-Me-4-OCF2H
I
2-Me-4-OCF2H
OMe
2-Me-4-OCF2H


Br
2-Me-4-OCH2CF3
I
2-Me-4-OCH2CF3
OMe
2-Me-4-OCH2CF3


Br
2-Me-4-SCF3
I
2-Me-4-SCF3
OMe
2-Me-4-SCF3


Br
2-Me-4-SOCF3
I
2-Me-4-SOCF3
OMe
2-Me-4-SOCF3


Br
2-Me-4-SO2CF3
I
2-Me-4-SO2CF3
OMe
2-Me-4-SO2CF3


Br
2-Me-4-SCF2H
I
2-Me-4-SCF2H
OMe
2-Me-4-SCF2H


Br
2-Me-4-SOCF2H
I
2-Me-4-SOCF2H
OMe
2-Me-4-SOCF2H


Br
2-Me-4-SO2CF2H
I
2-Me-4-SO2CF2H
OMe
2-Me-4-SO2CF2H


CF3
2-Me-4-CF3
NO2
2-Me-4-CF3
SMe
2-Me-4-CF3


CF3
2-Me-4-OCF3
NO2
2-Me-4-OCF3
SMe
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
NO2
2-Me-4-OCF2H
SMe
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
NO2
2-Me-4-OCH2CF3
SMe
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
NO2
2-Me-4-SCF3
SMe
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
NO2
2-Me-4-SOCF3
SMe
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
NO2
2-Me-4-SO2CF3
SMe
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
NO2
2-Me-4-SCF2H
SMe
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
NO2
2-Me-4-SOCF2H
SMe
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
NO2
2-Me-4-SO2CF2H
SMe
2-Me-4-SO2CF2H
















TABLE 4













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


Cl
2-CF3
Cl
3-CF3
Cl
4-CF3


Cl
2-OCF3
Cl
3-OCF3
Cl
4-OCF3


Cl
2-OCF2H
Cl
3-OCF2H
Cl
4-OCF2H


Cl
2-OCF2CF2H
Cl
3-OCF2CF2H
Cl
4-OCF2CF2H


Cl
2-OCH2CF3
Cl
3-OCH2CF3
Cl
4-OCH2CF3


Cl
2-SCF3
Cl
3-SCF3
Cl
4-SCF3


Cl
2-SOCF3
Cl
3-SOCF3
Cl
4-SOCF3


Cl
2-SO2CF3
Cl
3-SO2CF3
Cl
4-SO2CF3


Cl
2-SCF2H
Cl
3-SCF2H
Cl
4-SCF2H


Cl
2-SOCF2H
Cl
3-SOCF2H
Cl
4-SOCF2H


Cl
2-SO2CF2H
Cl
3-SO2CF2H
Cl
4-SO2CF2H


F
2-CF3
F
3-CF3
F
4-CF3


F
2-OCF3
F
3-OCF3
F
4-OCF3


F
2-OCF2H
F
3-OCF2H
F
4-OCF2H


F
2-OCF2CF2H
F
3-OCF2CF2H
F
4-OCF2CF2H


F
2-OCH2CF3
F
3-OCH2CF3
F
4-OCH2CF3


F
2-SCF3
F
3-SCF3
F
4-SCF3


F
2-SOCF3
F
3-SOCF3
F
4-SOCF3


F
2-SO2CF3
F
3-SO2CF3
F
4-SO2CF3


F
2-SCF2H
F
3-SCF2H
F
4-SCF2H


F
2-SOCF2H
F
3-SOCF2H
F
4-SOCF2H


F
2-SO2CF2H
F
3-SO2CF2H
F
4-SO2CF2H


Br
2-CF3
Br
3-CF3
Br
4-CF3


Br
2-OCF3
Br
3-OCF3
Br
4-OCF3


Br
2-OCF2H
Br
3-OCF2H
Br
4-OCF2H


Br
2-OCF2CF2H
Br
3-OCF2CF2H
Br
4-OCF2CF2H


Br
2-OCH2CF3
Br
3-OCH2CF3
Br
4-OCH2CF3


Br
2-SCF3
Br
3-SCF3
Br
4-SCF3


Br
2-SOCF3
Br
3-SOCF3
Br
4-SOCF3


Br
2-SO2CF3
Br
3-SO2CF3
Br
4-SO2CF3


Br
2-SCF2H
Br
3-SCF2H
Br
4-SCF2H


Br
2-SOCF2H
Br
3-SOCF2H
Br
4-SOCF2H


Br
2-SO2CF2H
Br
3-SO2CF2H
Br
4-SO2CF2H


I
2-CF3
I
3-CF3
I
4-CF3


I
2-OCF3
I
3-OCF3
I
4-OCF3


I
2-OCF2H
I
3-OCF2H
I
4-OCF2H


I
2-OCF2CF2H
I
3-OCF2CF2H
I
4-OCF2CF2H


I
2-OCH2CF3
I
3-OCH2CF3
I
4-OCH2CF3


I
2-SCF3
I
3-SCF3
I
4-SCF3


I
2-SOCF3
I
3-SOCF3
I
4-SOCF3


I
2-SO2CF3
I
3-SO2CF3
I
4-SO2CF3


I
2-SCF2H
I
3-SCF2H
I
4-SCF2H


I
2-SOCF2H
I
3-SOCF2H
I
4-SOCF2H


I
2-SO2CF2H
I
3-SO2CF2H
I
4-SO2CF2H


OMe
2-CF3
OMe
3-CF3
OMe
4-CF3


OMe
2-OCF3
OMe
3-OCF3
OMe
4-OCF3


OMe
2-OCF2H
OMe
3-OCF2H
OMe
4-OCF2H


OMe
2-OCF2CF2H
OMe
3-OCF2CF2H
OMe
4-OCF2CF2H


OMe
2-OCH2CF3
OMe
3-OCH2CF3
OMe
4-OCH2CF3


OMe
2-SCF3
OMe
3-SCF3
OMe
4-SCF3


OMe
2-SOCF3
OMe
3-SOCF3
OMe
4-SOCF3


OMe
2-SO2CF3
OMe
3-SO2CF3
OMe
4-SO2CF3


OMe
2-SCF2H
OMe
3-SCF2H
OMe
4-SCF2H


OMe
2-SOCF2H
OMe
3-SOCF2H
OMe
4-SOCF2H


OMe
2-SO2CF2H
OMe
3-SO2CF2H
OMe
4-SO2CF2H


CF3
2-CF3
CF3
3-CF3
CF3
4-CF3


CF3
2-OCF3
CF3
3-OCF3
CF3
4-OCF3


CF3
2-OCF2H
CF3
3-OCF2H
CF3
4-OCF2H


CF3
2-OCF2CF2H
CF3
3-OCF2CF2H
CF3
4-OCF2CF2H


CF3
2-OCH2CF3
CF3
3-OCH2CF3
CF3
4-OCH2CF3


CF3
2-SCF3
CF3
3-SCF3
CF3
4-SCF3


CF3
2-SOCF3
CF3
3-SOCF3
CF3
4-SOCF3


CF3
2-SO2CF3
CF3
3-SO2CF3
CF3
4-SO2CF3


CF3
2-SCF2H
CF3
3-SCF2H
CF3
4-SCF2H


CF3
2-SOCF2H
CF3
3-SOCF2H
CF3
4-SOCF2H


CF3
2-SO2CF2H
CF3
3-SO2CF2H
CF3
4-SO2CF2H


OCF2H
2-CF3
OCF2H
3-CF3
OCF2H
4-CF3


OCF2H
2-OCF3
OCF2H
3-OCF3
OCF2H
4-OCF3


OCF2H
2-OCF2H
OCF2H
3-OCF2H
OCF2H
4-OCF2H


OCF2H
2-OCF2CF2H
OCF2H
3-OCF2CF2H
OCF2H
4-OCF2CF2H


OCF2H
2-OCH2CF3
OCF2H
3-OCH2CF3
OCF2H
4-OCH2CF3


OCF2H
2-SCF3
OCF2H
3-SCF3
OCF2H
4-SCF3


OCF2H
2-SOCF3
OCF2H
3-SOCF3
OCF2H
4-SOCF3


OCF2H
2-SO2CF3
OCF2H
3-SO2CF3
OCF2H
4-SO2CF3


OCF2H
2-SCF2H
OCF2H
3-SCF2H
OCF2H
4-SCF2H


OCF2H
2-SOCF2H
OCF2H
3-SOCF2H
OCF2H
4-SOCF2H


OCF2H
2-SO2CF2H
OCF2H
3-SO2CF2H
OCF2H
4-SO2CF2H


Me
2-Me-4-CF3
F
2-Me-4-CF3
Cl
2-Me-4-CF3


Me
2-Me-4-OCF3
F
2-Me-4-OCF3
Cl
2-Me-4-OCF3


Me
2-Me-4-OCF2H
F
2-Me-4-OCF2H
Cl
2-Me-4-OCF2H


Me
2-Me-4-OCH2CF3
F
2-Me-4-OCH2CF3
Cl
2-Me-4-OCH2CF3


Me
2-Me-4-SCF3
F
2-Me-4-SCF3
Cl
2-Me-4-SCF3


Me
2-Me-4-SOCF3
F
2-Me-4-SOCF3
Cl
2-Me-4-SOCF3


Me
2-Me-4-SO2CF3
F
2-Me-4-SO2CF3
Cl
2-Me-4-SO2CF3


Me
2-Me-4-SCF2H
F
2-Me-4-SCF2H
Cl
2-Me-4-SCF2H


Me
2-Me-4-SOCF2H
F
2-Me-4-SOCF2H
Cl
2-Me-4-SOCF2H


Me
2-Me-4-SO2CF2H
F
2-Me-4-SO2CF2H
Cl
2-Me-4-SO2CF2H


Br
2-Me-4-CF3
I
2-Me-4-CF3
OMe
2-Me-4-CF3


Br
2-Me-4-OCF3
I
2-Me-4-OCF3
OMe
2-Me-4-OCF3


Br
2-Me-4-OCF2H
I
2-Me-4-OCF2H
OMe
2-Me-4-OCF2H


Br
2-Me-4-OCH2CF3
I
2-Me-4-OCH2CF3
OMe
2-Me-4-OCH2CF3


Br
2-Me-4-SCF3
I
2-Me-4-SCF3
OMe
2-Me-4-SCF3


Br
2-Me-4-SOCF3
I
2-Me-4-SOCF3
OMe
2-Me-4-SOCF3


Br
2-Me-4-SO2CF3
I
2-Me-4-SO2CF3
OMe
2-Me-4-SO2CF3


Br
2-Me-4-SCF2H
I
2-Me-4-SCF2H
OMe
2-Me-4-SCF2H


Br
2-Me-4-SOCF2H
I
2-Me-4-SOCF2H
OMe
2-Me-4-SOCF2H


Br
2-Me-4-SO2CF2H
I
2-Me-4-SO2CF2H
OMe
2-Me-4-SO2CF2H


CF3
2-Me-4-CF3
NO2
2-Me-4-CF3
SMe
2-Me-4-CF3


CF3
2-Me-4-OCF3
NO2
2-Me-4-OCF3
SMe
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
NO2
2-Me-4-OCF2H
SMe
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
NO2
2-Me-4-OCH2CF3
SMe
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
NO2
2-Me-4-SCF3
SMe
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
NO2
2-Me-4-SOCF3
SMe
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
NO2
2-Me-4-SO2CF3
SMe
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
NO2
2-Me-4-SCF2H
SMe
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
NO2
2-Me-4-SOCF2H
SMe
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
NO2
2-Me-4-SO2CF2H
SMe
2-Me-4-SO2CF2H
















TABLE 5













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


CF3
2-Me-4-CF3
CF2H
2-Me-4-CF3
CH2CF3
2-Me-4-CF3


CF3
2-Me-4-OCF3
CF2H
2-Me-4-OCF3
CH2CF3
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
CF2H
2-Me-4-OCF2H
CH2CF3
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
CF2H
2-Me-4-OCH2CF3
CH2CF3
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
CF2H
2-Me-4-SCF3
CH2CF3
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
CF2H
2-Me-4-SOCF3
CH2CF3
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
CF2H
2-Me-4-SO2CF3
CH2CF3
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
CF2H
2-Me-4-SCF2H
CH2CF3
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
CF2H
2-Me-4-SOCF2H
CH2CF3
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
CF2H
2-Me-4-SO2CF2H
CH2CF3
2-Me-4-SO2CF2H
















TABLE 6













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


CF3
2-Me-4-CF3
CF2H
2-Me-4-CF3
CH2CF3
2-Me-4-CF3


CF3
2-Me-4-OCF3
CF2H
2-Me-4-OCF3
CH2CF3
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
CF2H
2-Me-4-OCF2H
CH2CF3
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
CF2H
2-Me-4-OCH2CF3
CH2CF3
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
CF2H
2-Me-4-SCF3
CH2CF3
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
CF2H
2-Me-4-SOCF3
CH2CF3
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
CF2H
2-Me-4-SO2CF3
CH2CF3
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
CF2H
2-Me-4-SCF2H
CH2CF3
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
CF2H
2-Me-4-SOCF2H
CH2CF3
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
CF2H
2-Me-4-SO2CF2H
CH2CF3
2-Me-4-SO2CF2H
















TABLE 7













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


Cl
2-CF3
Cl
3-CF3
Cl
4-CF3


Cl
2-OCF3
Cl
3-OCF3
Cl
4-OCF3


Cl
2-OCF2H
Cl
3-OCF2H
Cl
4-OCF2H


Cl
2-OCF2CF2H
Cl
3-OCF2CF2H
Cl
4-OCF2CF2H


Cl
2-OCH2CF3
Cl
3-OCH2CF3
Cl
4-OCH2CF3


Cl
2-SCF3
Cl
3-SCF3
Cl
4-SCF3


Cl
2-SOCF3
Cl
3-SOCF3
Cl
4-SOCF3


Cl
2-SO2CF3
Cl
3-SO2CF3
Cl
4-SO2CF3


Cl
2-SCF2H
Cl
3-SCF2H
Cl
4-SCF2H


Cl
2-SOCF2H
Cl
3-SOCF2H
Cl
4-SOCF2H


Cl
2-SO2CF2H
Cl
3-SO2CF2H
Cl
4-SO2CF2H


F
2-CF3
F
3-CF3
F
4-CF3


F
2-OCF3
F
3-OCF3
F
4-OCF3


F
2-OCF2H
F
3-OCF2H
F
4-OCF2H


F
2-OCF2CF2H
F
3-OCF2CF2H
F
4-OCF2CF2H


F
2-OCH2CF3
F
3-OCH2CF3
F
4-OCH2CF3


F
2-SCF3
F
3-SCF3
F
4-SCF3


F
2-SOCF3
F
3-SOCF3
F
4-SOCF3


F
2-SO2CF3
F
3-SO2CF3
F
4-SO2CF3


F
2-SCF2H
F
3-SCF2H
F
4-SCF2H


F
2-SOCF2H
F
3-SOCF2H
F
4-SOCF2H


F
2-SO2CF2H
F
3-SO2CF2H
F
4-SO2CF2H


Br
2-CF3
Br
3-CF3
Br
4-CF3


Br
2-OCF3
Br
3-OCF3
Br
4-OCF3


Br
2-OCF2H
Br
3-OCF2H
Br
4-OCF2H


Br
2-OCF2CF2H
Br
3-OCF2CF2H
Br
4-OCF2CF2H


Br
2-OCH2CF3
Br
3-OCH2CF3
Br
4-OCH2CF3


Br
2-SCF3
Br
3-SCF3
Br
4-SCF3


Br
2-SOCF3
Br
3-SOCF3
Br
4-SOCF3


Br
2-SO2CF3
Br
3-SO2CF3
Br
4-SO2CF3


Br
2-SCF2H
Br
3-SCF2H
Br
4-SCF2H


Br
2-SOCF2H
Br
3-SOCF2H
Br
4-SOCF2H


Br
2-SO2CF2H
Br
3-SO2CF2H
Br
4-SO2CF2H


I
2-CF3
I
3-CF3
I
4-CF3


I
2-OCF3
I
3-OCF3
I
4-OCF3


I
2-OCF2H
I
3-OCF2H
I
4-OCF2H


I
2-OCF2CF2H
I
3-OCF2CF2H
I
4-OCF2CF2H


I
2-OCH2CF3
I
3-OCH2CF3
I
4-OCH2CF3


I
2-SCF3
I
3-SCF3
I
4-SCF3


I
2-SOCF3
I
3-SOCF3
I
4-SOCF3


I
2-SO2CF3
I
3-SO2CF3
I
4-SO2CF3


I
2-SCF2H
I
3-SCF2H
I
4-SCF2H


I
2-SOCF2H
I
3-SOCF2H
I
4-SOCF2H


I
2-SO2CF2H
I
3-SO2CF2H
I
4-SO2CF2H


OMe
2-CF3
OMe
3-CF3
OMe
4-CF3


OMe
2-OCF3
OMe
3-OCF3
OMe
4-OCF3


OMe
2-OCF2H
OMe
3-OCF2H
OMe
4-OCF2H


OMe
2-OCF2CF2H
OMe
3-OCF2CF2H
OMe
4-OCF2CF2H


OMe
2-OCH2CF3
OMe
3-OCH2CF3
OMe
4-OCH2CF3


OMe
2-SCF3
OMe
3-SCF3
OMe
4-SCF3


OMe
2-SOCF3
OMe
3-SOCF3
OMe
4-SOCF3


OMe
2-SO2CF3
OMe
3-SO2CF3
OMe
4-SO2CF3


OMe
2-SCF2H
OMe
3-SCF2H
OMe
4-SCF2H


OMe
2-SOCF2H
OMe
3-SOCF2H
OMe
4-SOCF2H


OMe
2-SO2CF2H
OMe
3-SO2CF2H
OMe
4-SO2CF2H


CF3
2-CF3
CF3
3-CF3
CF3
4-CF3


CF3
2-OCF3
CF3
3-OCF3
CF3
4-OCF3


CF3
2-OCF2H
CF3
3-OCF2H
CF3
4-OCF2H


CF3
2-OCF2CF2H
CF3
3-OCF2CF2H
CF3
4-OCF2CF2H


CF3
2-OCH2CF3
CF3
3-OCH2CF3
CF3
4-OCH2CF3


CF3
2-SCF3
CF3
3-SCF3
CF3
4-SCF3


CF3
2-SOCF3
CF3
3-SOCF3
CF3
4-SOCF3


CF3
2-SO2CF3
CF3
3-SO2CF3
CF3
4-SO2CF3


CF3
2-SCF2H
CF3
3-SCF2H
CF3
4-SCF2H


CF3
2-SOCF2H
CF3
3-SOCF2H
CF3
4-SOCF2H


CF3
2-SO2CF2H
CF3
3-SO2CF2H
CF3
4-SO2CF2H


OCF2H
2-CF3
OCF2H
3-CF3
OCF2H
4-CF3


OCF2H
2-OCF3
OCF2H
3-OCF3
OCF2H
4-OCF3


OCF2H
2-OCF2H
OCF2H
3-OCF2H
OCF2H
4-OCF2H


OCF2H
2-OCF2CF2H
OCF2H
3-OCF2CF2H
OCF2H
4-OCF2CF2H


OCF2H
2-OCH2CF3
OCF2H
3-OCH2CF3
OCF2H
4-OCH2CF3


OCF2H
2-SCF3
OCF2H
3-SCF3
OCF2H
4-SCF3


OCF2H
2-SOCF3
OCF2H
3-SOCF3
OCF2H
4-SOCF3


OCF2H
2-SO2CF3
OCF2H
3-SO2CF3
OCF2H
4-SO2CF3


OCF2H
2-SCF2H
OCF2H
3-SCF2H
OCF2H
4-SCF2H


OCF2H
2-SOCF2H
OCF2H
3-SOCF2H
OCF2H
4-SOCF2H


OCF2H
2-SO2CF2H
OCF2H
3-SO2CF2H
OCF2H
4-SO2CF2H


Me
2-Me-4-CF3
F
2-Me-4-CF3
Cl
2-Me-4-CF3


Me
2-Me-4-OCF3
F
2-Me-4-OCF3
Cl
2-Me-4-OCF3


Me
2-Me-4-OCF2H
F
2-Me-4-OCF2H
Cl
2-Me-4-OCF2H


Me
2-Me-4-OCH2CF3
F
2-Me-4-OCH2CF3
Cl
2-Me-4-OCH2CF3


Me
2-Me-4-SCF3
F
2-Me-4-SCF3
Cl
2-Me-4-SCF3


Me
2-Me-4-SOCF3
F
2-Me-4-SOCF3
Cl
2-Me-4-SOCF3


Me
2-Me-4-SO2CF3
F
2-Me-4-SO2CF3
Cl
2-Me-4-SO2CF3


Me
2-Me-4-SCF2H
F
2-Me-4-SCF2H
Cl
2-Me-4-SCF2H


Me
2-Me-4-SOCF2H
F
2-Me-4-SOCF2H
Cl
2-Me-4-SOCF2H


Me
2-Me-4-SO2CF2H
F
2-Me-4-SO2CF2H
Cl
2-Me-4-SO2CF2H


Br
2-Me-4-CF3
I
2-Me-4-CF3
OMe
2-Me-4-CF3


Br
2-Me-4-OCF3
I
2-Me-4-OCF3
OMe
2-Me-4-OCF3


Br
2-Me-4-OCF2H
I
2-Me-4-OCF2H
OMe
2-Me-4-OCF2H


Br
2-Me-4-OCH2CF3
I
2-Me-4-OCH2CF3
OMe
2-Me-4-OCH2CF3


Br
2-Me-4-SCF3
I
2-Me-4-SCF3
OMe
2-Me-4-SCF3


Br
2-Me-4-SOCF3
I
2-Me-4-SOCF3
OMe
2-Me-4-SOCF3


Br
2-Me-4-SO2CF3
I
2-Me-4-SO2CF3
OMe
2-Me-4-SO2CF3


Br
2-Me-4-SCF2H
I
2-Me-4-SCF2H
OMe
2-Me-4-SCF2H


Br
2-Me-4-SOCF2H
I
2-Me-4-SOCF2H
OMe
2-Me-4-SOCF2H


Br
2-Me-4-SO2CF2H
I
2-Me-4-SO2CF2H
OMe
2-Me-4-SO2CF2H


CF3
2-Me-4-CF3
NO2
2-Me-4-CF3
SMe
2-Me-4-CF3


CF3
2-Me-4-OCF3
NO2
2-Me-4-OCF3
SMe
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
NO2
2-Me-4-OCF2H
SMe
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
NO2
2-Me-4-OCH2CF3
SMe
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
NO2
2-Me-4-SCF3
SMe
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
NO2
2-Me-4-SOCF3
SMe
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
NO2
2-Me-4-SO2CF3
SMe
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
NO2
2-Me-4-SCF2H
SMe
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
NO2
2-Me-4-SOCF2H
SMe
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
NO2
2-Me-4-SO2CF2H
SMe
2-Me-4-SO2CF2H
















TABLE 8













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


Cl
2-CF3
Cl
3-CF3
Cl
4-CF3


Cl
2-OCF3
Cl
3-OCF3
Cl
4-OCF3


Cl
2-OCF2H
Cl
3-OCF2H
Cl
4-OCF2H


Cl
2-OCF2CF2H
Cl
3-OCF2CF2H
Cl
4-OCF2CF2H


Cl
2-OCH2CF3
Cl
3-OCH2CF3
Cl
4-OCH2CF3


Cl
2-SCF3
Cl
3-SCF3
Cl
4-SCF3


Cl
2-SOCF3
Cl
3-SOCF3
Cl
4-SOCF3


Cl
2-SO2CF3
Cl
3-SO2CF3
Cl
4-SO2CF3


Cl
2-SCF2H
Cl
3-SCF2H
Cl
4-SCF2H


Cl
2-SOCF2H
Cl
3-SOCF2H
Cl
4-SOCF2H


Cl
2-SO2CF2H
Cl
3-SO2CF2H
Cl
4-SO2CF2H


F
2-CF3
F
3-CF3
F
4-CF3


F
2-OCF3
F
3-OCF3
F
4-OCF3


F
2-OCF2H
F
3-OCF2H
F
4-OCF2H


F
2-OCF2CF2H
F
3-OCF2CF2H
F
4-OCF2CF2H


F
2-OCH2CF3
F
3-OCH2CF3
F
4-OCH2CF3


F
2-SCF3
F
3-SCF3
F
4-SCF3


F
2-SOCF3
F
3-SOCF3
F
4-SOCF3


F
2-SO2CF3
F
3-SO2CF3
F
4-SO2CF3


F
2-SCF2H
F
3-SCF2H
F
4-SCF2H


F
2-SOCF2H
F
3-SOCF2H
F
4-SOCF2H


F
2-SO2CF2H
F
3-SO2CF2H
F
4-SO2CF2H


Br
2-CF3
Br
3-CF3
Br
4-CF3


Br
2-OCF3
Br
3-OCF3
Br
4-OCF3


Br
2-OCF2H
Br
3-OCF2H
Br
4-OCF2H


Br
2-OCF2CF2H
Br
3-OCF2CF2H
Br
4-OCF2CF2H


Br
2-OCH2CF3
Br
3-OCH2CF3
Br
4-OCH2CF3


Br
2-SCF3
Br
3-SCF3
Br
4-SCF3


Br
2-SOCF3
Br
3-SOCF3
Br
4-SOCF3


Br
2-SO2CF3
Br
3-SO2CF3
Br
4-SO2CF3


Br
2-SCF2H
Br
3-SCF2H
Br
4-SCF2H


Br
2-SOCF2H
Br
3-SOCF2H
Br
4-SOCF2H


Br
2-SO2CF2H
Br
3-SO2CF2H
Br
4-SO2CF2H


I
2-CF3
I
3-CF3
I
4-CF3


I
2-OCF3
I
3-OCF3
I
4-OCF3


I
2-OCF2H
I
3-OCF2H
I
4-OCF2H


I
2-OCF2CF2H
I
3-OCF2CF2H
I
4-OCF2CF2H


I
2-OCH2CF3
I
3-OCH2CF3
I
4-OCH2CF3


I
2-SCF3
I
3-SCF3
I
4-SCF3


I
2-SOCF3
I
3-SOCF3
I
4-SOCF3


I
2-SO2CF3
I
3-SO2CF3
I
4-SO2CF3


I
2-SCF2H
I
3-SCF2H
I
4-SCF2H


I
2-SOCF2H
I
3-SOCF2H
I
4-SOCF2H


I
2-SO2CF2H
I
3-SO2CF2H
I
4-SO2CF2H


OMe
2-CF3
OMe
3-CF3
OMe
4-CF3


OMe
2-OCF3
OMe
3-OCF3
OMe
4-OCF3


OMe
2-OCF2H
OMe
3-OCF2H
OMe
4-OCF2H


OMe
2-OCF2CF2H
OMe
3-OCF2CF2H
OMe
4-OCF2CF2H


OMe
2-OCH2CF3
OMe
3-OCH2CF3
OMe
4-OCH2CF3


OMe
2-SCF3
OMe
3-SCF3
OMe
4-SCF3


OMe
2-SOCF3
OMe
3-SOCF3
OMe
4-SOCF3


OMe
2-SO2CF3
OMe
3-SO2CF3
OMe
4-SO2CF3


OMe
2-SCF2H
OMe
3-SCF2H
OMe
4-SCF2H


OMe
2-SOCF2H
OMe
3-SOCF2H
OMe
4-SOCF2H


OMe
2-SO2CF2H
OMe
3-SO2CF2H
OMe
4-SO2CF2H


CF3
2-CF3
CF3
3-CF3
CF3
4-CF3


CF3
2-OCF3
CF3
3-OCF3
CF3
4-OCF3


CF3
2-OCF2H
CF3
3-OCF2H
CF3
4-OCF2H


CF3
2-OCF2CF2H
CF3
3-OCF2CF2H
CF3
4-OCF2CF2H


CF3
2-OCH2CF3
CF3
3-OCH2CF3
CF3
4-OCH2CF3


CF3
2-SCF3
CF3
3-SCF3
CF3
4-SCF3


CF3
2-SOCF3
CF3
3-SOCF3
CF3
4-SOCF3


CF3
2-SO2CF3
CF3
3-SO2CF3
CF3
4-SO2CF3


CF3
2-SCF2H
CF3
3-SCF2H
CF3
4-SCF2H


CF3
2-SOCF2H
CF3
3-SOCF2H
CF3
4-SOCF2H


CF3
2-SO2CF2H
CF3
3-SO2CF2H
CF3
4-SO2CF2H


OCF2H
2-CF3
OCF2H
3-CF3
OCF2H
4-CF3


OCF2H
2-OCF3
OCF2H
3-OCF3
OCF2H
4-OCF3


OCF2H
2-OCF2H
OCF2H
3-OCF2H
OCF2H
4-OCF2H


OCF2H
2-OCF2CF2H
OCF2H
3-OCF2CF2H
OCF2H
4-OCF2CF2H


OCF2H
2-OCH2CF3
OCF2H
3-OCH2CF3
OCF2H
4-OCH2CF3


OCF2H
2-SCF3
OCF2H
3-SCF3
OCF2H
4-SCF3


OCF2H
2-SOCF3
OCF2H
3-SOCF3
OCF2H
4-SOCF3


OCF2H
2-SO2CF3
OCF2H
3-SO2CF3
OCF2H
4-SO2CF3


OCF2H
2-SCF2H
OCF2H
3-SCF2H
OCF2H
4-SCF2H


OCF2H
2-SOCF2H
OCF2H
3-SOCF2H
OCF2H
4-SOCF2H


OCF2H
2-SO2CF2H
OCF2H
3-SO2CF2H
OCF2H
4-SO2CF2H


Me
2-Me-4-CF3
F
2-Me-4-CF3
Cl
2-Me-4-CF3


Me
2-Me-4-OCF3
F
2-Me-4-OCF3
Cl
2-Me-4-OCF3


Me
2-Me-4-OCF2H
F
2-Me-4-OCF2H
Cl
2-Me-4-OCF2H


Me
2-Me-4-OCH2CF3
F
2-Me-4-OCH2CF3
Cl
2-Me-4-OCH2CF3


Me
2-Me-4-SCF3
F
2-Me-4-SCF3
Cl
2-Me-4-SCF3


Me
2-Me-4-SOCF3
F
2-Me-4-SOCF3
Cl
2-Me-4-SOCF3


Me
2-Me-4-SO2CF3
F
2-Me-4-SO2CF3
Cl
2-Me-4-SO2CF3


Me
2-Me-4-SCF2H
F
2-Me-4-SCF2H
Cl
2-Me-4-SCF2H


Me
2-Me-4-SOCF2H
F
2-Me-4-SOCF2H
Cl
2-Me-4-SOCF2H


Me
2-Me-4-SO2CF2H
F
2-Me-4-SO2CF2H
Cl
2-Me-4-SO2CF2H


Br
2-Me-4-CF3
I
2-Me-4-CF3
OMe
2-Me-4-CF3


Br
2-Me-4-OCF3
I
2-Me-4-OCF3
OMe
2-Me-4-OCF3


Br
2-Me-4-OCF2H
I
2-Me-4-OCF2H
OMe
2-Me-4-OCF2H


Br
2-Me-4-OCH2CF3
I
2-Me-4-OCH2CF3
OMe
2-Me-4-OCH2CF3


Br
2-Me-4-SCF3
I
2-Me-4-SCF3
OMe
2-Me-4-SCF3


Br
2-Me-4-SOCF3
I
2-Me-4-SOCF3
OMe
2-Me-4-SOCF3


Br
2-Me-4-SO2CF3
I
2-Me-4-SO2CF3
OMe
2-Me-4-SO2CF3


Br
2-Me-4-SCF2H
I
2-Me-4-SCF2H
OMe
2-Me-4-SCF2H


Br
2-Me-4-SOCF2H
I
2-Me-4-SOCF2H
OMe
2-Me-4-SOCF2H


Br
2-Me-4-SO2CF2H
I
2-Me-4-SO2CF2H
OMe
2-Me-4-SO2CF2H


CF3
2-Me-4-CF3
NO2
2-Me-4-CF3
SMe
2-Me-4-CF3


CF3
2-Me-4-OCF3
NO2
2-Me-4-OCF3
SMe
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
NO2
2-Me-4-OCF2H
SMe
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
NO2
2-Me-4-OCH2CF3
SMe
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
NO2
2-Me-4-SCF3
SMe
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
NO2
2-Me-4-SOCF3
SMe
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
NO2
2-Me-4-SO2CF3
SMe
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
NO2
2-Me-4-SCF2H
SMe
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
NO2
2-Me-4-SOCF2H
SMe
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
NO2
2-Me-4-SO2CF2H
SMe
2-Me-4-SO2CF2H
















TABLE 9













 












R4
(R5)m
R4
(R5)m
R4
(R5)m





Me
2-CF3
Me
3-CF3
Me
4-CF3


Me
2-OCF3
Me
3-OCF3
Me
4-OCF3


Me
2-OCF2H
Me
3-OCF2H
Me
4-OCF2H


Me
2-OCF2CF2H
Me
3-OCF2CF2H
Me
4-OCF2CF2H


Me
2-OCH2CF3
Me
3-OCH2CF3
Me
4-OCH2CF3


Me
2-SCF3
Me
3-SCF3
Me
4-SCF3


Me
2-SOCF3
Me
3-SOCF3
Me
4-SOCF3


Me
2-SO2CF3
Me
3-SO2CF3
Me
4-SO2CF3


Me
2-SCF2H
Me
3-SCF2H
Me
4-SCF2H


Me
2-SOCF2H
Me
3-SOCF2H
Me
4-SOCF2H


Me
2-SO2CF2H
Me
3-SO2CF2H
Me
4-SO2CF2H


Cl
2-CF3
Cl
3-CF3
Cl
4-CF3


Cl
2-OCF3
Cl
3-OCF3
Cl
4-OCF3


Cl
2-OCF2H
Cl
3-OCF2H
Cl
4-OCF2H


Cl
2-OCF2CF2H
Cl
3-OCF2CF2H
Cl
4-OCF2CF2H


Cl
2-OCH2CF3
Cl
3-OCH2CF3
Cl
4-OCH2CF3


Cl
2-SCF3
Cl
3-SCF3
Cl
4-SCF3


Cl
2-SOCF3
Cl
3-SOCF3
Cl
4-SOCF3


Cl
2-SO2CF3
Cl
3-SO2CF3
Cl
4-SO2CF3


Cl
2-SCF2H
Cl
3-SCF2H
Cl
4-SCF2H


Cl
2-SOCF2H
Cl
3-SOCF2H
Cl
4-SOCF2H


Cl
2-SO2CF2H
Cl
3-SO2CF2H
Cl
4-SO2CF2H


F
2-CF3
F
3-CF3
F
4-CF3


F
2-OCF3
F
3-OCF3
F
4-OCF3


F
2-OCF2H
F
3-OCF2H
F
4-OCF2H


F
2-OCF2CF2H
F
3-OCF2CF2H
F
4-OCF2CF2H


F
2-OCH2CF3
F
3-OCH2CF3
F
4-OCH2CF3


F
2-SCF3
F
3-SCF3
F
4-SCF3


F
2-SOCF3
F
3-SOCF3
F
4-SOCF3


F
2-SO2CF3
F
3-SO2CF3
F
4-SO2CF3


F
2-SCF2H
F
3-SCF2H
F
4-SCF2H


F
2-SOCF2H
F
3-SOCF2H
F
4-SOCF2H


F
2-SO2CF2H
F
3-SO2CF2H
F
4-SO2CF2H


Br
2-CF3
Br
3-CF3
Br
4-CF3


Br
2-OCF3
Br
3-OCF3
Br
4-OCF3


Br
2-OCF2H
Br
3-OCF2H
Br
4-OCF2H


Br
2-OCF2CF2H
Br
3-OCF2CF2H
Br
4-OCF2CF2H


Br
2-OCH2CF3
Br
3-OCH2CF3
Br
4-OCH2CF3


Br
2-SCF3
Br
3-SCF3
Br
4-SCF3


Br
2-SOCF3
Br
3-SOCF3
Br
4-SOCF3


Br
2-SO2CF3
Br
3-SO2CF3
Br
4-SO2CF3


Br
2-SCF2H
Br
3-SCF2H
Br
4-SCF2H


Br
2-SOCF2H
Br
3-SOCF2H
Br
4-SOCF2H


Br
2-SO2CF2H
Br
3-SO2CF2H
Br
4-SO2CF2H


I
2-CF3
I
3-CF3
I
4-CF3


I
2-OCF3
I
3-OCF3
I
4-OCF3


I
2-OCF2H
I
3-OCF2H
I
4-OCF2H


I
2-OCF2CF2H
I
3-OCF2CF2H
I
4-OCF2CF2H


I
2-OCH2CF3
I
3-OCH2CF3
I
4-OCH2CF3


I
2-SCF3
I
3-SCF3
I
4-SCF3


I
2-SOCF3
I
3-SOCF3
I
4-SOCF3


I
2-SO2CF3
I
3-SO2CF3
I
4-SO2CF3


I
2-SCF2H
I
3-SCF2H
I
4-SCF2H


I
2-SOCF2H
I
3-SOCF2H
I
4-SOCF2H


I
2-SO2CF2H
I
3-SO2CF2H
I
4-SO2CF2H


OMe
2-CF3
OMe
3-CF3
OMe
4-CF3


OMe
2-OCF3
OMe
3-OCF3
OMe
4-OCF3


OMe
2-OCF2H
OMe
3-OCF2H
OMe
4-OCF2H


OMe
2-OCF2CF2H
OMe
3-OCF2CF2H
OMe
4-OCF2CF2H


OMe
2-OCH2CF3
OMe
3-OCH2CF3
OMe
4-OCH2CF3


OMe
2-SCF3
OMe
3-SCF3
OMe
4-SCF3


OMe
2-SOCF3
OMe
3-SOCF3
OMe
4-SOCF3


OMe
2-SO2CF3
OMe
3-SO2CF3
OMe
4-SO2CF3


OMe
2-SCF2H
OMe
3-SCF2H
OMe
4-SCF2H


OMe
2-SOCF2H
OMe
3-SOCF2H
OMe
4-SOCF2H


OMe
2-SO2CF2H
OMe
3-SO2CF2H
OMe
4-SO2CF2H


CF3
2-CF3
CF3
3-CF3
CF3
4-CF3


CF3
2-OCF3
CF3
3-OCF3
CF3
4-OCF3


CF3
2-OCF2H
CF3
3-OCF2H
CF3
4-OCF2H


CF3
2-OCF2CF2H
CF3
3-OCF2CF2H
CF3
4-OCF2CF2H


CF3
2-OCH2CF3
CF3
3-OCH2CF3
CF3
4-OCH2CF3


CF3
2-SCF3
CF3
3-SCF3
CF3
4-SCF3


CF3
2-SOCF3
CF3
3-SOCF3
CF3
4-SOCF3


CF3
2-SO2CF3
CF3
3-SO2CF3
CF3
4-SO2CF3


CF3
2-SCF2H
CF3
3-SCF2H
CF3
4-SCF2H


CF3
2-SOCF2H
CF3
3-SOCF2H
CF3
4-SOCF2H


CF3
2-SO2CF2H
CF3
3-SO2CF2H
CF3
4-SO2CF2H


OCF2H
2-CF3
OCF2H
3-CF3
OCF2H
4-CF3


OCF2H
2-OCF3
OCF2H
3-OCF3
OCF2H
4-OCF3


OCF2H
2-OCF2H
OCF2H
3-OCF2H
OCF2H
4-OCF2H


OCF2H
2-OCF2CF2H
OCF2H
3-OCF2CF2H
OCF2H
4-OCF2CF2H


OCF2H
2-OCH2CF3
OCF2H
3-OCH2CF3
OCF2H
4-OCH2CF3


OCF2H
2-SCF3
OCF2H
3-SCF3
OCF2H
4-SCF3


OCF2H
2-SOCF3
OCF2H
3-SOCF3
OCF2H
4-SOCF3


OCF2H
2-SO2CF3
OCF2H
3-SO2CF3
OCF2H
4-SO2CF3


OCF2H
2-SCF2H
OCF2H
3-SCF2H
OCF2H
4-SCF2H


OCF2H
2-SOCF2H
OCF2H
3-SOCF2H
OCF2H
4-SOCF2H


OCF2H
2-SO2CF2H
OCF2H
3-SO2CF2H
OCF2H
4-SO2CF2H


Me
2-Me-4-CF3
F
2-Me-4-CF3
Cl
2-Me-4-CF3


Me
2-Me-4-OCF3
F
2-Me-4-OCF3
Cl
2-Me-4-OCF3


Me
2-Me-4-OCF2H
F
2-Me-4-OCF2H
Cl
2-Me-4-OCF2H


Me
2-Me-4-OCH2CF3
F
2-Me-4-OCH2CF3
Cl
2-Me-4-OCH2CF3


Me
2-Me-4-SCF3
F
2-Me-4-SCF3
Cl
2-Me-4-SCF3


Me
2-Me-4-SOCF3
F
2-Me-4-SOCF3
Cl
2-Me-4-SOCF3


Me
2-Me-4-SO2CF3
F
2-Me-4-SO2CF3
Cl
2-Me-4-SO2CF3


Me
2-Me-4-SCF2H
F
2-Me-4-SCF2H
Cl
2-Me-4-SCF2H


Me
2-Me-4-SOCF2H
F
2-Me-4-SOCF2H
Cl
2-Me-4-SOCF2H


Me
2-Me-4-SO2CF2H
F
2-Me-4-SO2CF2H
Cl
2-Me-4-SO2CF2H


Br
2-Me-4-CF3
I
2-Me-4-CF3
OMe
2-Me-4-CF3


Br
2-Me-4-OCF3
I
2-Me-4-OCF3
OMe
2-Me-4-OCF3


Br
2-Me-4-OCF2H
I
2-Me-4-OCF2H
OMe
2-Me-4-OCF2H


Br
2-Me-4-OCH2CF3
I
2-Me-4-OCH2CF3
OMe
2-Me-4-OCH2CF3


Br
2-Me-4-SCF3
I
2-Me-4-SCF3
OMe
2-Me-4-SCF3


Br
2-Me-4-SOCF3
I
2-Me-4-SOCF3
OMe
2-Me-4-SOCF3


Br
2-Me-4-SO2CF3
I
2-Me-4-SO2CF3
OMe
2-Me-4-SO2CF3


Br
2-Me-4-SCF2H
I
2-Me-4-SCF2H
OMe
2-Me-4-SCF2H


Br
2-Me-4-SOCF2H
I
2-Me-4-SOCF2H
OMe
2-Me-4-SOCF2H


Br
2-Me-4-SO2CF2H
I
2-Me-4-SO2CF2H
OMe
2-Me-4-SO2CF2H


CF3
2-Me-4-CF3
NO2
2-Me-4-CF3
SMe
2-Me-4-CF3


CF3
2-Me-4-OCF3
NO2
2-Me-4-OCF3
SMe
2-Me-4-OCF3


CF3
2-Me-4-OCF2H
NO2
2-Me-4-OCF2H
SMe
2-Me-4-OCF2H


CF3
2-Me-4-OCH2CF3
NO2
2-Me-4-OCH2CF3
SMe
2-Me-4-OCH2CF3


CF3
2-Me-4-SCF3
NO2
2-Me-4-SCF3
SMe
2-Me-4-SCF3


CF3
2-Me-4-SOCF3
NO2
2-Me-4-SOCF3
SMe
2-Me-4-SOCF3


CF3
2-Me-4-SO2CF3
NO2
2-Me-4-SO2CF3
SMe
2-Me-4-SO2CF3


CF3
2-Me-4-SCF2H
NO2
2-Me-4-SCF2H
SMe
2-Me-4-SCF2H


CF3
2-Me-4-SOCF2H
NO2
2-Me-4-SOCF2H
SMe
2-Me-4-SOCF2H


CF3
2-Me-4-SO2CF2H
NO2
2-Me-4-SO2CF2H
SMe
2-Me-4-SO2CF2H
















TABLE 10













 










R4
(R5)m







Me
2-CF3



Me
2-OCF3



Me
2-OCF2H



Me
2-OCF2CF2H



Me
2-OCH2CF3



Me
2-SCF3



Me
2-SOCF3



Me
2-SO2CF3



Me
2-SCF2H



Me
2-SOCF2H



Me
2-SO2CF2H



Me
3-CF3



Me
3-OCF3



Me
3-OCF2H



Me
3-OCF2CF3H



Me
3-OCH2CF3



Me
3-SCF3



Me
3-SOCF3



Me
3-SO2CF3



Me
3-SCF2H



Me
3-SOCF2H



Me
3-SO2CF2H



Me
4-CF3



Me
4-OCF3



Me
4-OCF2H



Me
4-OCF2CF3H



Me
4-OCH2CF3



Me
4-SCF3



Me
4-SOCF3



Me
4-SO2CF3



Me
4-SCF2H



Me
4-SOCF2H



Me
4-SO2CF2H



Cl
2-CF3



Cl
2-OCF3



Cl
2-OCF2H



Cl
2-OCF2CF2H



Cl
2-OCH2CF3



Cl
2-SCF3



Cl
2-SOCF3



Cl
2-SO2CF3



Cl
2-SCF2H



Cl
2-SOCF2H



Cl
2-SO2CF2H



Cl
3-CF3



Cl
3-OCF3



Cl
3-OCF2H



Cl
3-OCF2CF3H



Cl
3-OCH2CF3



Cl
3-SCF3



Cl
3-SOCF3



Cl
3-SO2CF3



Cl
3-SCF2H



Cl
3-SOCF2H



Cl
3-SO2CF2H



Cl
4-CF3



Cl
4-OCF3



Cl
4-OCF2H



Cl
4-OCF2CF3H



Cl
4-OCH2CF3



Cl
4-SCF3



Cl
4-SOCF3



Cl
4-SO2CF3



Cl
4-SCF2H



Cl
4-SOCF2H



Cl
4-SO2CF2H



F
2-CF3



F
2-OCF3



F
2-OCF2H



F
2-OCF2CF2H



F
2-OCH2CF3



F
2-SCF3



F
2-SOCF3



F
2-SO2CF3



F
2-SCF2H



F
2-SOCF2H



F
2-SO2CF2H



F
3-CF3



F
3-OCF3



F
3-OCF2H



F
3-OCF2CF3H



F
3-OCH2CF3



F
3-SCF3



F
3-SOCF3



F
3-SO2CF3



F
3-SCF2H



F
3-SOCF2H



F
3-SO2CF2H



F
4-CF3



F
4-OCF3



F
4-OCF2H



F
4-OCF2CF3H



F
4-OCH2CF3



F
4-SCF3



F
4-SOCF3



F
4-SO2CF3



F
4-SCF2H



F
4-SOCF2H



F
4-SO2CF2H



Br
2-CF3



Br
2-OCF3



Br
2-OCF2H



Br
2-OCF2CF2H



Br
2-OCH2CF3



Br
2-SCF3



Br
2-SOCF3



Br
2-SO2CF3



Br
2-SCF2H



Br
2-SOCF2H



Br
2-SO2CF2H



Br
3-CF3



Br
3-OCF3



Br
3-OCF2H



Br
3-OCF2CF3H



Br
3-OCH2CF3



Br
3-SCF3



Br
3-SOCF3



Br
3-SO2CF3



Br
3-SCF2H



Br
3-SOCF2H



Br
3-SO2CF2H



Br
4-CF3



Br
4-OCF3



Br
4-OCF2H



Br
4-OCF2CF3H



Br
4-OCH2CF3



Br
4-SCF3



Br
4-SOCF3



Br
4-SO2CF3



Br
4-SCF2H



Br
4-SOCF2H



Br
4-SO2CF2H



I
2-CF3



I
2-OCF3



I
2-OCF2H



I
2-OCF2CF2H



I
2-OCH2CF3



I
2-SCF3



I
2-SOCF3



I
2-SO2CF3



I
2-SCF2H



I
2-SOCF2H



I
2-SO2CF2H



I
3-CF3



I
3-OCF3



I
3-OCF2H



I
3-OCF2CF3H



I
3-OCH2CF3



I
3-SCF3



I
3-SOCF3



I
3-SO2CF3



I
3-SCF2H



I
3-SOCF2H



I
3-SO2CF2H



I
4-CF3



I
4-OCF3



I
4-OCF2H



I
4-OCF2CF3H



I
4-OCH2CF3



I
4-SCF3



I
4-SOCF3



I
4-SO2CF3



I
4-SCF2H



I
4-SOCF2H



I
4-SO2CF2H



OMe
2-CF3



OMe
2-OCF3



OMe
2-OCF2H



OMe
2-OCF2CF2H



OMe
2-OCH2CF3



OMe
2-SCF3



OMe
2-SOCF3



OMe
2-SO2CF3



OMe
2-SCF2H



OMe
2-SOCF2H



OMe
2-SO2CF2H



OMe
3-CF3



OMe
3-OCF3



OMe
3-OCF2H



OMe
3-OCF2CF3H



OMe
3-OCH2CF3



OMe
3-SCF3



OMe
3-SOCF3



OMe
3-SO2CF3



OMe
3-SCF2H



OMe
3-SOCF2H



OMe
3-SO2CF2H



OMe
4-CF3



OMe
4-OCF3



OMe
4-OCF2H



OMe
4-OCF2CF3H



OMe
4-OCH2CF3



OMe
4-SCF3



OMe
4-SOCF3



OMe
4-SO2CF3



OMe
4-SCF2H



OMe
4-SOCF2H



OMe
4-SO2CF2H



CF3
2-CF3



CF3
2-OCF3



CF3
2-OCF2H



CF3
2-OCF2CF2H



CF3
2-OCH2CF3



CF3
2-SCF3



CF3
2-SOCF3



CF3
2-SO2CF3



CF3
2-SCF2H



CF3
2-SOCF2H



CF3
2-SO2CF2H



CF3
3-CF3



CF3
3-OCF3



CF3
3-OCF2H



CF3
3-OCF2CF3H



CF3
3-OCH2CF3



CF3
3-SCF3



CF3
3-SOCF3



CF3
3-SO2CF3



CF3
3-SCF2H



CF3
3-SOCF2H



CF3
3-SO2CF2H



CF3
4-CF3



CF3
4-OCF3



CF3
4-OCF2H



CF3
4-OCF2CF3H



CF3
4-OCH2CF3



CF3
4-SCF3



CF3
4-SOCF3



CF3
4-SO2CF3



CF3
4-SCF2H



CF3
4-SOCF2H



CF3
4-SO2CF2H



OCF2H
2-CF3



OCF2H
2-OCF3



OCF2H
2-OCF2H



OCF2H
2-OCF2CF2H



OCF2H
2-OCH2CF3



OCF2H
2-SCF3



OCF2H
2-SOCF3



OCF2H
2-SO2CF3



OCF2H
2-SCF2H



OCF2H
2-SOCF2H



OCF2H
2-SO2CF2H



OCF2H
3-CF3



OCF2H
3-OCF3



OCF2H
3-OCF2H



OCF2H
3-OCF2CF3H



OCF2H
3-OCH2CF3



OCF2H
3-SCF3



OCF2H
3-SOCF3



OCF2H
3-SO2CF3



OCF2H
3-SCF2H



OCF2H
3-SOCF2H



OCF2H
3-SO2CF2H



OCF2H
4-CF3



OCF2H
4-OCF3



OCF2H
4-OCF2H



OCF2H
4-OCF2CF3H



OCF2H
4-OCH2CF3



OCF2H
4-SCF3



OCF2H
4-SOCF3



OCF2H
4-SO2CF3



OCF2H
4-SCF2H



OCF2H
4-SOCF2H



OCF2H
4-SO2CF2H



Me
2-Me-4-CF3



Me
2-Me-4-OCF3



Me
2-Me-4-OCF2H



Me
2-Me-4-OCH2CF3



Me
2-Me-4-SCF3



Me
2-Me-4-SOCF3



Me
2-Me-4-SO2CF3



Me
2-Me-4-SCF2H



Me
2-Me-4-SOCF2H



Me
2-Me-4-SO2CF2H



Br
2-Me-4-CF3



Br
2-Me-4-OCF3



Br
2-Me-4-OCF2H



Br
2-Me-4-OCH2CF3



Br
2-Me-4-SCF3



Br
2-Me-4-SOCF3



Br
2-Me-4-SO2CF3



Br
2-Me-4-SCF2H



Br
2-Me-4-SOCF2H



Br
2-Me-4-SO2CF2H



CF3
2-Me-4-CF3



CF3
2-Me-4-OCF3



CF3
2-Me-4-OCF2H



CF3
2-Me-4-OCH2CF3



CF3
2-Me-4-SCF3



CF3
2-Me-4-SOCF3



CF3
2-Me-4-SO2CF3



CF3
2-Me-4-SCF2H



CF3
2-Me-4-SOCF2H



CF3
2-Me-4-SO2CF2H



F
2-Me-4-CF3



F
2-Me-4-OCF3



F
2-Me-4-OCF2H



F
2-Me-4-OCH2CF3



F
2-Me-4-SCF3



F
2-Me-4-SOCF3



F
2-Me-4-SO2CF3



F
2-Me-4-SCF2H



F
2-Me-4-SOCF2H



F
2-Me-4-SO2CF2H



I
2-Me-4-CF3



I
2-Me-4-OCF3



I
2-Me-4-OCF2H



I
2-Me-4-OCH2CF3



I
2-Me-4-SCF3



I
2-Me-4-SOCF3



I
2-Me-4-SO2CF3



I
2-Me-4-SCF2H



I
2-Me-4-SOCF2H



I
2-Me-4-SO2CF2H



NO2
2-Me-4-CF3



NO2
2-Me-4-OCF3



NO2
2-Me-4-OCF2H



NO2
2-Me-4-OCH2CF3



NO2
2-Me-4-SCF3



NO2
2-Me-4-SOCF3



NO2
2-Me-4-SO2CF3



NO2
2-Me-4-SCF2H



NO2
2-Me-4-SOCF2H



NO2
2-Me-4-SO2CF2H



Cl
2-Me-4-CF3



Cl
2-Me-4-OCF3



Cl
2-Me-4-OCF2H



Cl
2-Me-4-OCH2CF3



Cl
2-Me-4-SCF3



Cl
2-Me-4-SOCF3



Cl
2-Me-4-SO2CF3



Cl
2-Me-4-SCF2H



Cl
2-Me-4-SOCF2H



Cl
2-Me-4-SO2CF2H



OMe
2-Me-4-CF3



OMe
2-Me-4-OCF3



OMe
2-Me-4-OCF2H



OMe
2-Me-4-OCH2CF3



OMe
2-Me-4-SCF3



OMe
2-Me-4-SOCF3



OMe
2-Me-4-SO2CF3



OMe
2-Me-4-SCF2H



OMe
2-Me-4-SOCF2H



OMe
2-Me-4-SO2CF2H



SMe
2-Me-4-CF3



SMe
2-Me-4-OCF3



SMe
2-Me-4-OCF2H



SMe
2-Me-4-OCH2CF3



SMe
2-Me-4-SCF3



SMe
2-Me-4-SOCF3



SMe
2-Me-4-SO2CF3



SMe
2-Me-4-SCF2H



SMe
2-Me-4-SOCF2H



SMe
2-Me-4-SO2CF2H

















TABLE 11













 










R4
(R5)m







Me
2-CF3



Me
2-OCF3



Me
2-OCF2H



Me
2-OCF2CF2H



Me
2-OCH2CF3



Me
2-SCF3



Me
2-SOCF3



Me
2-SO2CF3



Me
2-SCF2H



Me
2-SOCF2H



Me
2-SO2CF2H



Me
3-CF3



Me
3-OCF3



Me
3-OCF2H



Me
3-OCF2CF3H



Me
3-OCH2CF3



Me
3-SCF3



Me
3-SOCF3



Me
3-SO2CF3



Me
3-SCF2H



Me
3-SOCF2H



Me
3-SO2CF2H



Me
4-CF3



Me
4-OCF3



Me
4-OCF2H



Me
4-OCF2CF3H



Me
4-OCH2CF3



Me
4-SCF3



Me
4-SOCF3



Me
4-SO2CF3



Me
4-SCF2H



Me
4-SOCF2H



Me
4-SO2CF2H



Cl
2-CF3



Cl
2-OCF3



Cl
2-OCF2H



Cl
2-OCF2CF2H



Cl
2-OCH2CF3



Cl
2-SCF3



Cl
2-SOCF3



Cl
2-SO2CF3



Cl
2-SCF2H



Cl
2-SOCF2H



Cl
2-SO2CF2H



Cl
3-CF3



Cl
3-OCF3



Cl
3-OCF2H



Cl
3-OCF2CF3H



Cl
3-OCH2CF3



Cl
3-SCF3



Cl
3-SOCF3



Cl
3-SO2CF3



Cl
3-SCF2H



Cl
3-SOCF2H



Cl
3-SO2CF2H



Cl
4-CF3



Cl
4-OCF3



Cl
4-OCF2H



Cl
4-OCF2CF3H



Cl
4-OCH2CF3



Cl
4-SCF3



Cl
4-SOCF3



Cl
4-SO2CF3



Cl
4-SCF2H



Cl
4-SOCF2H



Cl
4-SO2CF2H



F
2-CF3



F
2-OCF3



F
2-OCF2H



F
2-OCF2CF2H



F
2-OCH2CF3



F
2-SCF3



F
2-SOCF3



F
2-SO2CF3



F
2-SCF2H



F
2-SOCF2H



F
2-SO2CF2H



F
3-CF3



F
3-OCF3



F
3-OCF2H



F
3-OCF2CF3H



F
3-OCH2CF3



F
3-SCF3



F
3-SOCF3



F
3-SO2CF3



F
3-SCF2H



F
3-SOCF2H



F
3-SO2CF2H



F
4-CF3



F
4-OCF3



F
4-OCF2H



F
4-OCF2CF3H



F
4-OCH2CF3



F
4-SCF3



F
4-SOCF3



F
4-SO2CF3



F
4-SCF2H



F
4-SOCF2H



F
4-SO2CF2H



Br
2-CF3



Br
2-OCF3



Br
2-OCF2H



Br
2-OCF2CF2H



Br
2-OCH2CF3



Br
2-SCF3



Br
2-SOCF3



Br
2-SO2CF3



Br
2-SCF2H



Br
2-SOCF2H



Br
2-SO2CF2H



Br
3-CF3



Br
3-OCF3



Br
3-OCF2H



Br
3-OCF2CF3H



Br
3-OCH2CF3



Br
3-SCF3



Br
3-SOCF3



Br
3-SO2CF3



Br
3-SCF2H



Br
3-SOCF2H



Br
3-SO2CF2H



Br
4-CF3



Br
4-OCF3



Br
4-OCF2H



Br
4-OCF2CF3H



Br
4-OCH2CF3



Br
4-SCF3



Br
4-SOCF3



Br
4-SO2CF3



Br
4-SCF2H



Br
4-SOCF2H



Br
4-SO2CF2H



I
2-CF3



I
2-OCF3



I
2-OCF2H



I
2-OCF2CF2H



I
2-OCH2CF3



I
2-SCF3



I
2-SOCF3



I
2-SO2CF3



I
2-SCF2H



I
2-SOCF2H



I
2-SO2CF2H



I
3-CF3



I
3-OCF3



I
3-OCF2H



I
3-OCF2CF3H



I
3-OCH2CF3



I
3-SCF3



I
3-SOCF3



I
3-SO2CF3



I
3-SCF2H



I
3-SOCF2H



I
3-SO2CF2H



I
4-CF3



I
4-OCF3



I
4-OCF2H



I
4-OCF2CF3H



I
4-OCH2CF3



I
4-SCF3



I
4-SOCF3



I
4-SO2CF3



I
4-SCF2H



I
4-SOCF2H



I
4-SO2CF2H



OMe
2-CF3



OMe
2-OCF3



OMe
2-OCF2H



OMe
2-OCF2CF2H



OMe
2-OCH2CF3



OMe
2-SCF3



OMe
2-SOCF3



OMe
2-SO2CF3



OMe
2-SCF2H



OMe
2-SOCF2H



OMe
2-SO2CF2H



OMe
3-CF3



OMe
3-OCF3



OMe
3-OCF2H



OMe
3-OCF2CF3H



OMe
3-OCH2CF3



OMe
3-SCF3



OMe
3-SOCF3



OMe
3-SO2CF3



OMe
3-SCF2H



OMe
3-SOCF2H



OMe
3-SO2CF2H



OMe
4-CF3



OMe
4-OCF3



OMe
4-OCF2H



OMe
4-OCF2CF3H



OMe
4-OCH2CF3



OMe
4-SCF3



OMe
4-SOCF3



OMe
4-SO2CF3



OMe
4-SCF2H



OMe
4-SOCF2H



OMe
4-SO2CF2H



CF3
2-CF3



CF3
2-OCF3



CF3
2-OCF2H



CF3
2-OCF2CF2H



CF3
2-OCH2CF3



CF3
2-SCF3



CF3
2-SOCF3



CF3
2-SO2CF3



CF3
2-SCF2H



CF3
2-SOCF2H



CF3
2-SO2CF2H



CF3
3-CF3



CF3
3-OCF3



CF3
3-OCF2H



CF3
3-OCF2CF3H



CF3
3-OCH2CF3



CF3
3-SCF3



CF3
3-SOCF3



CF3
3-SO2CF3



CF3
3-SCF2H



CF3
3-SOCF2H



CF3
3-SO2CF2H



CF3
4-CF3



CF3
4-OCF3



CF3
4-OCF2H



CF3
4-OCF2CF3H



CF3
4-OCH2CF3



CF3
4-SCF3



CF3
4-SOCF3



CF3
4-SO2CF3



CF3
4-SCF2H



CF3
4-SOCF2H



CF3
4-SO2CF2H



OCF2H
2-CF3



OCF2H
2-OCF3



OCF2H
2-OCF2H



OCF2H
2-OCF2CF2H



OCF2H
2-OCH2CF3



OCF2H
2-SCF3



OCF2H
2-SOCF3



OCF2H
2-SO2CF3



OCF2H
2-SCF2H



OCF2H
2-SOCF2H



OCF2H
2-SO2CF2H



OCF2H
3-CF3



OCF2H
3-OCF3



OCF2H
3-OCF2H



OCF2H
3-OCF2CF3H



OCF2H
3-OCH2CF3



OCF2H
3-SCF3



OCF2H
3-SOCF3



OCF2H
3-SO2CF3



OCF2H
3-SCF2H



OCF2H
3-SOCF2H



OCF2H
3-SO2CF2H



OCF2H
4-CF3



OCF2H
4-OCF3



OCF2H
4-OCF2H



OCF2H
4-OCF2CF3H



OCF2H
4-OCH2CF3



OCF2H
4-SCF3



OCF2H
4-SOCF3



OCF2H
4-SO2CF3



OCF2H
4-SCF2H



OCF2H
4-SOCF2H



OCF2H
4-SO2CF2H



Me
2-Me-4-CF3



Me
2-Me-4-OCF3



Me
2-Me-4-OCF2H



Me
2-Me-4-OCH2CF3



Me
2-Me-4-SCF3



Me
2-Me-4-SOCF3



Me
2-Me-4-SO2CF3



Me
2-Me-4-SCF2H



Me
2-Me-4-SOCF2H



Me
2-Me-4-SO2CF2H



Br
2-Me-4-CF3



Br
2-Me-4-OCF3



Br
2-Me-4-OCF2H



Br
2-Me-4-OCH2CF3



Br
2-Me-4-SCF3



Br
2-Me-4-SOCF3



Br
2-Me-4-SO2CF3



Br
2-Me-4-SCF2H



Br
2-Me-4-SOCF2H



Br
2-Me-4-SO2CF2H



CF3
2-Me-4-CF3



CF3
2-Me-4-OCF3



CF3
2-Me-4-OCF2H



CF3
2-Me-4-OCH2CF3



CF3
2-Me-4-SCF3



CF3
2-Me-4-SOCF3



CF3
2-Me-4-SO2CF3



CF3
2-Me-4-SCF2H



CF3
2-Me-4-SOCF2H



CF3
2-Me-4-SO2CF2H



F
2-Me-4-CF3



F
2-Me-4-OCF3



F
2-Me-4-OCF2H



F
2-Me-4-OCH2CF3



F
2-Me-4-SCF3



F
2-Me-4-SOCF3



F
2-Me-4-SO2CF3



F
2-Me-4-SCF2H



F
2-Me-4-SOCF2H



F
2-Me-4-SO2CF2H



I
2-Me-4-CF3



I
2-Me-4-OCF3



I
2-Me-4-OCF2H



I
2-Me-4-OCH2CF3



I
2-Me-4-SCF3



I
2-Me-4-SOCF3



I
2-Me-4-SO2CF3



I
2-Me-4-SCF2H



I
2-Me-4-SOCF2H



I
2-Me-4-SO2CF2H



NO2
2-Me-4-CF3



NO2
2-Me-4-OCF3



NO2
2-Me-4-OCF2H



NO2
2-Me-4-OCH2CF3



NO2
2-Me-4-SCF3



NO2
2-Me-4-SOCF3



NO2
2-Me-4-SO2CF3



NO2
2-Me-4-SCF2H



NO2
2-Me-4-SOCF2H



NO2
2-Me-4-SO2CF2H



Cl
2-Me-4-CF3



Cl
2-Me-4-OCF3



Cl
2-Me-4-OCF2H



Cl
2-Me-4-OCH2CF3



Cl
2-Me-4-SCF3



Cl
2-Me-4-SOCF3



Cl
2-Me-4-SO2CF3



Cl
2-Me-4-SCF2H



Cl
2-Me-4-SOCF2H



Cl
2-Me-4-SO2CF2H



OMe
2-Me-4-CF3



OMe
2-Me-4-OCF3



OMe
2-Me-4-OCF2H



OMe
2-Me-4-OCH2CF3



OMe
2-Me-4-SCF3



OMe
2-Me-4-SOCF3



OMe
2-Me-4-SO2CF3



OMe
2-Me-4-SCF2H



OMe
2-Me-4-SOCF2H



OMe
2-Me-4-SO2CF2H



SMe
2-Me-4-CF3



SMe
2-Me-4-OCF3



SMe
2-Me-4-OCF2H



SMe
2-Me-4-OCH2CF3



SMe
2-Me-4-SCF3



SMe
2-Me-4-SOCF3



SMe
2-Me-4-SO2CF3



SMe
2-Me-4-SCF2H



SMe
2-Me-4-SOCF2H



SMe
2-Me-4-SO2CF2H

















TABLE 12













 










R4
(R5)m







Me
2-CF3



Me
2-OCF3



Me
2-OCF2H



Me
2-OCF2CF2H



Me
2-OCH2CF3



Me
2-SCF3



Me
2-SOCF3



Me
2-SO2CF3



Me
2-SCF2H



Me
2-SOCF2H



Me
2-SO2CF2H



Me
3-CF3



Me
3-OCF3



Me
3-OCF2H



Me
3-OCF2CF3H



Me
3-OCH2CF3



Me
3-SCF3



Me
3-SOCF3



Me
3-SO2CF3



Me
3-SCF2H



Me
3-SOCF2H



Me
3-SO2CF2H



Me
4-CF3



Me
4-OCF3



Me
4-OCF2H



Me
4-OCF2CF3H



Me
4-OCH2CF3



Me
4-SCF3



Me
4-SOCF3



Me
4-SO2CF3



Me
4-SCF2H



Me
4-SOCF2H



Me
4-SO2CF2H



Cl
2-CF3



Cl
2-OCF3



Cl
2-OCF2H



Cl
2-OCF2CF2H



Cl
2-OCH2CF3



Cl
2-SCF3



Cl
2-SOCF3



Cl
2-SO2CF3



Cl
2-SCF2H



Cl
2-SOCF2H



Cl
2-SO2CF2H



Cl
3-CF3



Cl
3-OCF3



Cl
3-OCF2H



Cl
3-OCF2CF3H



Cl
3-OCH2CF3



Cl
3-SCF3



Cl
3-SOCF3



Cl
3-SO2CF3



Cl
3-SCF2H



Cl
3-SOCF2H



Cl
3-SO2CF2H



Cl
4-CF3



Cl
4-OCF3



Cl
4-OCF2H



Cl
4-OCF2CF3H



Cl
4-OCH2CF3



Cl
4-SCF3



Cl
4-SOCF3



Cl
4-SO2CF3



Cl
4-SCF2H



Cl
4-SOCF2H



Cl
4-SO2CF2H



F
2-CF3



F
2-OCF3



F
2-OCF2H



F
2-OCF2CF2H



F
2-OCH2CF3



F
2-SCF3



F
2-SOCF3



F
2-SO2CF3



F
2-SCF2H



F
2-SOCF2H



F
2-SO2CF2H



F
3-CF3



F
3-OCF3



F
3-OCF2H



F
3-OCF2CF3H



F
3-OCH2CF3



F
3-SCF3



F
3-SOCF3



F
3-SO2CF3



F
3-SCF2H



F
3-SOCF2H



F
3-SO2CF2H



F
4-CF3



F
4-OCF3



F
4-OCF2H



F
4-OCF2CF3H



F
4-OCH2CF3



F
4-SCF3



F
4-SOCF3



F
4-SO2CF3



F
4-SCF2H



F
4-SOCF2H



F
4-SO2CF2H



Br
2-CF3



Br
2-OCF3



Br
2-OCF2H



Br
2-OCF2CF2H



Br
2-OCH2CF3



Br
2-SCF3



Br
2-SOCF3



Br
2-SO2CF3



Br
2-SCF2H



Br
2-SOCF2H



Br
2-SO2CF2H



Br
3-CF3



Br
3-OCF3



Br
3-OCF2H



Br
3-OCF2CF3H



Br
3-OCH2CF3



Br
3-SCF3



Br
3-SOCF3



Br
3-SO2CF3



Br
3-SCF2H



Br
3-SOCF2H



Br
3-SO2CF2H



Br
4-CF3



Br
4-OCF3



Br
4-OCF2H



Br
4-OCF2CF3H



Br
4-OCH2CF3



Br
4-SCF3



Br
4-SOCF3



Br
4-SO2CF3



Br
4-SCF2H



Br
4-SOCF2H



Br
4-SO2CF2H



I
2-CF3



I
2-OCF3



I
2-OCF2H



I
2-OCF2CF2H



I
2-OCH2CF3



I
2-SCF3



I
2-SOCF3



I
2-SO2CF3



I
2-SCF2H



I
2-SOCF2H



I
2-SO2CF2H



I
3-CF3



I
3-OCF3



I
3-OCF2H



I
3-OCF2CF3H



I
3-OCH2CF3



I
3-SCF3



I
3-SOCF3



I
3-SO2CF3



I
3-SCF2H



I
3-SOCF2H



I
3-SO2CF2H



I
4-CF3



I
4-OCF3



I
4-OCF2H



I
4-OCF2CF3H



I
4-OCH2CF3



I
4-SCF3



I
4-SOCF3



I
4-SO2CF3



I
4-SCF2H



I
4-SOCF2H



I
4-SO2CF2H



OMe
2-CF3



OMe
2-OCF3



OMe
2-OCF2H



OMe
2-OCF2CF2H



OMe
2-OCH2CF3



OMe
2-SCF3



OMe
2-SOCF3



OMe
2-SO2CF3



OMe
2-SCF2H



OMe
2-SOCF2H



OMe
2-SO2CF2H



OMe
3-CF3



OMe
3-OCF3



OMe
3-OCF2H



OMe
3-OCF2CF3H



OMe
3-OCH2CF3



OMe
3-SCF3



OMe
3-SOCF3



OMe
3-SO2CF3



OMe
3-SCF2H



OMe
3-SOCF2H



OMe
3-SO2CF2H



OMe
4-CF3



OMe
4-OCF3



OMe
4-OCF2H



OMe
4-OCF2CF3H



OMe
4-OCH2CF3



OMe
4-SCF3



OMe
4-SOCF3



OMe
4-SO2CF3



OMe
4-SCF2H



OMe
4-SOCF2H



OMe
4-SO2CF2H



CF3
2-CF3



CF3
2-OCF3



CF3
2-OCF2H



CF3
2-OCF2CF2H



CF3
2-OCH2CF3



CF3
2-SCF3



CF3
2-SOCF3



CF3
2-SO2CF3



CF3
2-SCF2H



CF3
2-SOCF2H



CF3
2-SO2CF2H



CF3
3-CF3



CF3
3-OCF3



CF3
3-OCF2H



CF3
3-OCF2CF3H



CF3
3-OCH2CF3



CF3
3-SCF3



CF3
3-SOCF3



CF3
3-SO2CF3



CF3
3-SCF2H



CF3
3-SOCF2H



CF3
3-SO2CF2H



CF3
4-CF3



CF3
4-OCF3



CF3
4-OCF2H



CF3
4-OCF2CF3H



CF3
4-OCH2CF3



CF3
4-SCF3



CF3
4-SOCF3



CF3
4-SO2CF3



CF3
4-SCF2H



CF3
4-SOCF2H



CF3
4-SO2CF2H



OCF2H
2-CF3



OCF2H
2-OCF3



OCF2H
2-OCF2H



OCF2H
2-OCF2CF2H



OCF2H
2-OCH2CF3



OCF2H
2-SCF3



OCF2H
2-SOCF3



OCF2H
2-SO2CF3



OCF2H
2-SCF2H



OCF2H
2-SOCF2H



OCF2H
2-SO2CF2H



OCF2H
3-CF3



OCF2H
3-OCF3



OCF2H
3-OCF2H



OCF2H
3-OCF2CF3H



OCF2H
3-OCH2CF3



OCF2H
3-SCF3



OCF2H
3-SOCF3



OCF2H
3-SO2CF3



OCF2H
3-SCF2H



OCF2H
3-SOCF2H



OCF2H
3-SO2CF2H



OCF2H
4-CF3



OCF2H
4-OCF3



OCF2H
4-OCF2H



OCF2H
4-OCF2CF3H



OCF2H
4-OCH2CF3



OCF2H
4-SCF3



OCF2H
4-SOCF3



OCF2H
4-SO2CF3



OCF2H
4-SCF2H



OCF2H
4-SOCF2H



OCF2H
4-SO2CF2H



Me
2-Me-4-CF3



Me
2-Me-4-OCF3



Me
2-Me-4-OCF2H



Me
2-Me-4-OCH2CF3



Me
2-Me-4-SCF3



Me
2-Me-4-SOCF3



Me
2-Me-4-SO2CF3



Me
2-Me-4-SCF2H



Me
2-Me-4-SOCF2H



Me
2-Me-4-SO2CF2H



Br
2-Me-4-CF3



Br
2-Me-4-OCF3



Br
2-Me-4-OCF2H



Br
2-Me-4-OCH2CF3



Br
2-Me-4-SCF3



Br
2-Me-4-SOCF3



Br
2-Me-4-SO2CF3



Br
2-Me-4-SCF2H



Br
2-Me-4-SOCF2H



Br
2-Me-4-SO2CF2H



CF3
2-Me-4-CF3



CF3
2-Me-4-OCF3



CF3
2-Me-4-OCF2H



CF3
2-Me-4-OCH2CF3



CF3
2-Me-4-SCF3



CF3
2-Me-4-SOCF3



CF3
2-Me-4-SO2CF3



CF3
2-Me-4-SCF2H



CF3
2-Me-4-SOCF2H



CF3
2-Me-4-SO2CF2H



F
2-Me-4-CF3



F
2-Me-4-OCF3



F
2-Me-4-OCF2H



F
2-Me-4-OCH2CF3



F
2-Me-4-SCF3



F
2-Me-4-SOCF3



F
2-Me-4-SO2CF3



F
2-Me-4-SCF2H



F
2-Me-4-SOCF2H



F
2-Me-4-SO2CF2H



I
2-Me-4-CF3



I
2-Me-4-OCF3



I
2-Me-4-OCF2H



I
2-Me-4-OCH2CF3



I
2-Me-4-SCF3



I
2-Me-4-SOCF3



I
2-Me-4-SO2CF3



I
2-Me-4-SCF2H



I
2-Me-4-SOCF2H



I
2-Me-4-SO2CF2H



NO2
2-Me-4-CF3



NO2
2-Me-4-OCF3



NO2
2-Me-4-OCF2H



NO2
2-Me-4-OCH2CF3



NO2
2-Me-4-SCF3



NO2
2-Me-4-SOCF3



NO2
2-Me-4-SO2CF3



NO2
2-Me-4-SCF2H



NO2
2-Me-4-SOCF2H



NO2
2-Me-4-SO2CF2H



Cl
2-Me-4-CF3



Cl
2-Me-4-OCF3



Cl
2-Me-4-OCF2H



Cl
2-Me-4-OCH2CF3



Cl
2-Me-4-SCF3



Cl
2-Me-4-SOCF3



Cl
2-Me-4-SO2CF3



Cl
2-Me-4-SCF2H



Cl
2-Me-4-SOCF2H



Cl
2-Me-4-SO2CF2H



OMe
2-Me-4-CF3



OMe
2-Me-4-OCF3



OMe
2-Me-4-OCF2H



OMe
2-Me-4-OCH2CF3



OMe
2-Me-4-SCF3



OMe
2-Me-4-SOCF3



OMe
2-Me-4-SO2CF3



OMe
2-Me-4-SCF2H



OMe
2-Me-4-SOCF2H



OMe
2-Me-4-SO2CF2H



SMe
2-Me-4-CF3



SMe
2-Me-4-OCF3



SMe
2-Me-4-OCF2H



SMe
2-Me-4-OCH2CF3



SMe
2-Me-4-SCF3



SMe
2-Me-4-SOCF3



SMe
2-Me-4-SO2CF3



SMe
2-Me-4-SCF2H



SMe
2-Me-4-SOCF2H



SMe
2-Me-4-SO2CF2H

















TABLE 13













 










R4
(R5)m







Me
2-CF3



Me
2-OCF3



Me
2-OCF2H



Me
2-OCF2CF2H



Me
2-OCH2CF3



Me
2-SCF3



Me
2-SOCF3



Me
2-SO2CF3



Me
2-SCF2H



Me
2-SOCF2H



Me
2-SO2CF2H



Me
3-CF3



Me
3-OCF3



Me
3-OCF2H



Me
3-OCF2CF3H



Me
3-OCH2CF3



Me
3-SCF3



Me
3-SOCF3



Me
3-SO2CF3



Me
3-SCF2H



Me
3-SOCF2H



Me
3-SO2CF2H



Me
4-CF3



Me
4-OCF3



Me
4-OCF2H



Me
4-OCF2CF3H



Me
4-OCH2CF3



Me
4-SCF3



Me
4-SOCF3



Me
4-SO2CF3



Me
4-SCF2H



Me
4-SOCF2H



Me
4-SO2CF2H



Cl
2-CF3



Cl
2-OCF3



Cl
2-OCF2H



Cl
2-OCF2CF2H



Cl
2-OCH2CF3



Cl
2-SCF3



Cl
2-SOCF3



Cl
2-SO2CF3



Cl
2-SCF2H



Cl
2-SOCF2H



Cl
2-SO2CF2H



Cl
3-CF3



Cl
3-OCF3



Cl
3-OCF2H



Cl
3-OCF2CF3H



Cl
3-OCH2CF3



Cl
3-SCF3



Cl
3-SOCF3



Cl
3-SO2CF3



Cl
3-SCF2H



Cl
3-SOCF2H



Cl
3-SO2CF2H



Cl
4-CF3



Cl
4-OCF3



Cl
4-OCF2H



Cl
4-OCF2CF3H



Cl
4-OCH2CF3



Cl
4-SCF3



Cl
4-SOCF3



Cl
4-SO2CF3



Cl
4-SCF2H



Cl
4-SOCF2H



Cl
4-SO2CF2H



F
2-CF3



F
2-OCF3



F
2-OCF2H



F
2-OCF2CF2H



F
2-OCH2CF3



F
2-SCF3



F
2-SOCF3



F
2-SO2CF3



F
2-SCF2H



F
2-SOCF2H



F
2-SO2CF2H



F
3-CF3



F
3-OCF3



F
3-OCF2H



F
3-OCF2CF3H



F
3-OCH2CF3



F
3-SCF3



F
3-SOCF3



F
3-SO2CF3



F
3-SCF2H



F
3-SOCF2H



F
3-SO2CF2H



F
4-CF3



F
4-OCF3



F
4-OCF2H



F
4-OCF2CF3H



F
4-OCH2CF3



F
4-SCF3



F
4-SOCF3



F
4-SO2CF3



F
4-SCF2H



F
4-SOCF2H



F
4-SO2CF2H



Br
2-CF3



Br
2-OCF3



Br
2-OCF2H



Br
2-OCF2CF2H



Br
2-OCH2CF3



Br
2-SCF3



Br
2-SOCF3



Br
2-SO2CF3



Br
2-SCF2H



Br
2-SOCF2H



Br
2-SO2CF2H



Br
3-CF3



Br
3-OCF3



Br
3-OCF2H



Br
3-OCF2CF3H



Br
3-OCH2CF3



Br
3-SCF3



Br
3-SOCF3



Br
3-SO2CF3



Br
3-SCF2H



Br
3-SOCF2H



Br
3-SO2CF2H



Br
4-CF3



Br
4-OCF3



Br
4-OCF2H



Br
4-OCF2CF3H



Br
4-OCH2CF3



Br
4-SCF3



Br
4-SOCF3



Br
4-SO2CF3



Br
4-SCF2H



Br
4-SOCF2H



Br
4-SO2CF2H



I
2-CF3



I
2-OCF3



I
2-OCF2H



I
2-OCF2CF2H



I
2-OCH2CF3



I
2-SCF3



I
2-SOCF3



I
2-SO2CF3



I
2-SCF2H



I
2-SOCF2H



I
2-SO2CF2H



I
3-CF3



I
3-OCF3



I
3-OCF2H



I
3-OCF2CF3H



I
3-OCH2CF3



I
3-SCF3



I
3-SOCF3



I
3-SO2CF3



I
3-SCF2H



I
3-SOCF2H



I
3-SO2CF2H



I
4-CF3



I
4-OCF3



I
4-OCF2H



I
4-OCF2CF3H



I
4-OCH2CF3



I
4-SCF3



I
4-SOCF3



I
4-SO2CF3



I
4-SCF2H



I
4-SOCF2H



I
4-SO2CF2H



OMe
2-CF3



OMe
2-OCF3



OMe
2-OCF2H



OMe
2-OCF2CF2H



OMe
2-OCH2CF3



OMe
2-SCF3



OMe
2-SOCF3



OMe
2-SO2CF3



OMe
2-SCF2H



OMe
2-SOCF2H



OMe
2-SO2CF2H



OMe
3-CF3



OMe
3-OCF3



OMe
3-OCF2H



OMe
3-OCF2CF3H



OMe
3-OCH2CF3



OMe
3-SCF3



OMe
3-SOCF3



OMe
3-SO2CF3



OMe
3-SCF2H



OMe
3-SOCF2H



OMe
3-SO2CF2H



OMe
4-CF3



OMe
4-OCF3



OMe
4-OCF2H



OMe
4-OCF2CF3H



OMe
4-OCH2CF3



OMe
4-SCF3



OMe
4-SOCF3



OMe
4-SO2CF3



OMe
4-SCF2H



OMe
4-SOCF2H



OMe
4-SO2CF2H



CF3
2-CF3



CF3
2-OCF3



CF3
2-OCF2H



CF3
2-OCF2CF2H



CF3
2-OCH2CF3



CF3
2-SCF3



CF3
2-SOCF3



CF3
2-SO2CF3



CF3
2-SCF2H



CF3
2-SOCF2H



CF3
2-SO2CF2H



CF3
3-CF3



CF3
3-OCF3



CF3
3-OCF2H



CF3
3-OCF2CF3H



CF3
3-OCH2CF3



CF3
3-SCF3



CF3
3-SOCF3



CF3
3-SO2CF3



CF3
3-SCF2H



CF3
3-SOCF2H



CF3
3-SO2CF2H



CF3
4-CF3



CF3
4-OCF3



CF3
4-OCF2H



CF3
4-OCF2CF3H



CF3
4-OCH2CF3



CF3
4-SCF3



CF3
4-SOCF3



CF3
4-SO2CF3



CF3
4-SCF2H



CF3
4-SOCF2H



CF3
4-SO2CF2H



OCF2H
2-CF3



OCF2H
2-OCF3



OCF2H
2-OCF2H



OCF2H
2-OCF2CF2H



OCF2H
2-OCH2CF3



OCF2H
2-SCF3



OCF2H
2-SOCF3



OCF2H
2-SO2CF3



OCF2H
2-SCF2H



OCF2H
2-SOCF2H



OCF2H
2-SO2CF2H



OCF2H
3-CF3



OCF2H
3-OCF3



OCF2H
3-OCF2H



OCF2H
3-OCF2CF3H



OCF2H
3-OCH2CF3



OCF2H
3-SCF3



OCF2H
3-SOCF3



OCF2H
3-SO2CF3



OCF2H
3-SCF2H



OCF2H
3-SOCF2H



OCF2H
3-SO2CF2H



OCF2H
4-CF3



OCF2H
4-OCF3



OCF2H
4-OCF2H



OCF2H
4-OCF2CF3H



OCF2H
4-OCH2CF3



OCF2H
4-SCF3



OCF2H
4-SOCF3



OCF2H
4-SO2CF3



OCF2H
4-SCF2H



OCF2H
4-SOCF2H



OCF2H
4-SO2CF2H



Me
2-Me-4-CF3



Me
2-Me-4-OCF3



Me
2-Me-4-OCF2H



Me
2-Me-4-OCH2CF3



Me
2-Me-4-SCF3



Me
2-Me-4-SOCF3



Me
2-Me-4-SO2CF3



Me
2-Me-4-SCF2H



Me
2-Me-4-SOCF2H



Me
2-Me-4-SO2CF2H



Br
2-Me-4-CF3



Br
2-Me-4-OCF3



Br
2-Me-4-OCF2H



Br
2-Me-4-OCH2CF3



Br
2-Me-4-SCF3



Br
2-Me-4-SOCF3



Br
2-Me-4-SO2CF3



Br
2-Me-4-SCF2H



Br
2-Me-4-SOCF2H



Br
2-Me-4-SO2CF2H



CF3
2-Me-4-CF3



CF3
2-Me-4-OCF3



CF3
2-Me-4-OCF2H



CF3
2-Me-4-OCH2CF3



CF3
2-Me-4-SCF3



CF3
2-Me-4-SOCF3



CF3
2-Me-4-SO2CF3



CF3
2-Me-4-SCF2H



CF3
2-Me-4-SOCF2H



CF3
2-Me-4-SO2CF2H



F
2-Me-4-CF3



F
2-Me-4-OCF3



F
2-Me-4-OCF2H



F
2-Me-4-OCH2CF3



F
2-Me-4-SCF3



F
2-Me-4-SOCF3



F
2-Me-4-SO2CF3



F
2-Me-4-SCF2H



F
2-Me-4-SOCF2H



F
2-Me-4-SO2CF2H



I
2-Me-4-CF3



I
2-Me-4-OCF3



I
2-Me-4-OCF2H



I
2-Me-4-OCH2CF3



I
2-Me-4-SCF3



I
2-Me-4-SOCF3



I
2-Me-4-SO2CF3



I
2-Me-4-SCF2H



I
2-Me-4-SOCF2H



I
2-Me-4-SO2CF2H



NO2
2-Me-4-CF3



NO2
2-Me-4-OCF3



NO2
2-Me-4-OCF2H



NO2
2-Me-4-OCH2CF3



NO2
2-Me-4-SCF3



NO2
2-Me-4-SOCF3



NO2
2-Me-4-SO2CF3



NO2
2-Me-4-SCF2H



NO2
2-Me-4-SOCF2H



NO2
2-Me-4-SO2CF2H



Cl
2-Me-4-CF3



Cl
2-Me-4-OCF3



Cl
2-Me-4-OCF2H



Cl
2-Me-4-OCH2CF3



Cl
2-Me-4-SCF3



Cl
2-Me-4-SOCF3



Cl
2-Me-4-SO2CF3



Cl
2-Me-4-SCF2H



Cl
2-Me-4-SOCF2H



Cl
2-Me-4-SO2CF2H



OMe
2-Me-4-CF3



OMe
2-Me-4-OCF3



OMe
2-Me-4-OCF2H



OMe
2-Me-4-OCH2CF3



OMe
2-Me-4-SCF3



OMe
2-Me-4-SOCF3



OMe
2-Me-4-SO2CF3



OMe
2-Me-4-SCF2H



OMe
2-Me-4-SOCF2H



OMe
2-Me-4-SO2CF2H



SMe
2-Me-4-CF3



SMe
2-Me-4-OCF3



SMe
2-Me-4-OCF2H



SMe
2-Me-4-OCH2CF3



SMe
2-Me-4-SCF3



SMe
2-Me-4-SOCF3



SMe
2-Me-4-SO2CF3



SMe
2-Me-4-SCF2H



SMe
2-Me-4-SOCF2H



SMe
2-Me-4-SO2CF2H

















TABLE 14













 










R4
(R5)m







Me
2-CF3



Me
2-OCF3



Me
2-OCF2H



Me
2-OCF2CF2H



Me
2-OCH2CF3



Me
2-SCF3



Me
2-SOCF3



Me
2-SO2CF3



Me
2-SCF2H



Me
2-SOCF2H



Me
2-SO2CF2H



Me
3-CF3



Me
3-OCF3



Me
3-OCF2H



Me
3-OCF2CF3H



Me
3-OCH2CF3



Me
3-SCF3



Me
3-SOCF3



Me
3-SO2CF3



Me
3-SCF2H



Me
3-SOCF2H



Me
3-SO2CF2H



Me
4-CF3



Me
4-OCF3



Me
4-OCF2H



Me
4-OCF2CF3H



Me
4-OCH2CF3



Me
4-SCF3



Me
4-SOCF3



Me
4-SO2CF3



Me
4-SCF2H



Me
4-SOCF2H



Me
4-SO2CF2H



Cl
2-CF3



Cl
2-OCF3



Cl
2-OCF2H



Cl
2-OCF2CF2H



Cl
2-OCH2CF3



Cl
2-SCF3



Cl
2-SOCF3



Cl
2-SO2CF3



Cl
2-SCF2H



Cl
2-SOCF2H



Cl
2-SO2CF2H



Cl
3-CF3



Cl
3-OCF3



Cl
3-OCF2H



Cl
3-OCF2CF3H



Cl
3-OCH2CF3



Cl
3-SCF3



Cl
3-SOCF3



Cl
3-SO2CF3



Cl
3-SCF2H



Cl
3-SOCF2H



Cl
3-SO2CF2H



Cl
4-CF3



Cl
4-OCF3



Cl
4-OCF2H



Cl
4-OCF2CF3H



Cl
4-OCH2CF3



Cl
4-SCF3



Cl
4-SOCF3



Cl
4-SO2CF3



Cl
4-SCF2H



Cl
4-SOCF2H



Cl
4-SO2CF2H



F
2-CF3



F
2-OCF3



F
2-OCF2H



F
2-OCF2CF2H



F
2-OCH2CF3



F
2-SCF3



F
2-SOCF3



F
2-SO2CF3



F
2-SCF2H



F
2-SOCF2H



F
2-SO2CF2H



F
3-CF3



F
3-OCF3



F
3-OCF2H



F
3-OCF2CF3H



F
3-OCH2CF3



F
3-SCF3



F
3-SOCF3



F
3-SO2CF3



F
3-SCF2H



F
3-SOCF2H



F
3-SO2CF2H



F
4-CF3



F
4-OCF3



F
4-OCF2H



F
4-OCF2CF3H



F
4-OCH2CF3



F
4-SCF3



F
4-SOCF3



F
4-SO2CF3



F
4-SCF2H



F
4-SOCF2H



F
4-SO2CF2H



Br
2-CF3



Br
2-OCF3



Br
2-OCF2H



Br
2-OCF2CF2H



Br
2-OCH2CF3



Br
2-SCF3



Br
2-SOCF3



Br
2-SO2CF3



Br
2-SCF2H



Br
2-SOCF2H



Br
2-SO2CF2H



Br
3-CF3



Br
3-OCF3



Br
3-OCF2H



Br
3-OCF2CF3H



Br
3-OCH2CF3



Br
3-SCF3



Br
3-SOCF3



Br
3-SO2CF3



Br
3-SCF2H



Br
3-SOCF2H



Br
3-SO2CF2H



Br
4-CF3



Br
4-OCF3



Br
4-OCF2H



Br
4-OCF2CF3H



Br
4-OCH2CF3



Br
4-SCF3



Br
4-SOCF3



Br
4-SO2CF3



Br
4-SCF2H



Br
4-SOCF2H



Br
4-SO2CF2H



I
2-CF3



I
2-OCF3



I
2-OCF2H



I
2-OCF2CF2H



I
2-OCH2CF3



I
2-SCF3



I
2-SOCF3



I
2-SO2CF3



I
2-SCF2H



I
2-SOCF2H



I
2-SO2CF2H



I
3-CF3



I
3-OCF3



I
3-OCF2H



I
3-OCF2CF3H



I
3-OCH2CF3



I
3-SCF3



I
3-SOCF3



I
3-SO2CF3



I
3-SCF2H



I
3-SOCF2H



I
3-SO2CF2H



I
4-CF3



I
4-OCF3



I
4-OCF2H



I
4-OCF2CF3H



I
4-OCH2CF3



I
4-SCF3



I
4-SOCF3



I
4-SO2CF3



I
4-SCF2H



I
4-SOCF2H



I
4-SO2CF2H



OMe
2-CF3



OMe
2-OCF3



OMe
2-OCF2H



OMe
2-OCF2CF2H



OMe
2-OCH2CF3



OMe
2-SCF3



OMe
2-SOCF3



OMe
2-SO2CF3



OMe
2-SCF2H



OMe
2-SOCF2H



OMe
2-SO2CF2H



OMe
3-CF3



OMe
3-OCF3



OMe
3-OCF2H



OMe
3-OCF2CF3H



OMe
3-OCH2CF3



OMe
3-SCF3



OMe
3-SOCF3



OMe
3-SO2CF3



OMe
3-SCF2H



OMe
3-SOCF2H



OMe
3-SO2CF2H



OMe
4-CF3



OMe
4-OCF3



OMe
4-OCF2H



OMe
4-OCF2CF3H



OMe
4-OCH2CF3



OMe
4-SCF3



OMe
4-SOCF3



OMe
4-SO2CF3



OMe
4-SCF2H



OMe
4-SOCF2H



OMe
4-SO2CF2H



CF3
2-CF3



CF3
2-OCF3



CF3
2-OCF2H



CF3
2-OCF2CF2H



CF3
2-OCH2CF3



CF3
2-SCF3



CF3
2-SOCF3



CF3
2-SO2CF3



CF3
2-SCF2H



CF3
2-SOCF2H



CF3
2-SO2CF2H



CF3
3-CF3



CF3
3-OCF3



CF3
3-OCF2H



CF3
3-OCF2CF3H



CF3
3-OCH2CF3



CF3
3-SCF3



CF3
3-SOCF3



CF3
3-SO2CF3



CF3
3-SCF2H



CF3
3-SOCF2H



CF3
3-SO2CF2H



CF3
4-CF3



CF3
4-OCF3



CF3
4-OCF2H



CF3
4-OCF2CF3H



CF3
4-OCH2CF3



CF3
4-SCF3



CF3
4-SOCF3



CF3
4-SO2CF3



CF3
4-SCF2H



CF3
4-SOCF2H



CF3
4-SO2CF2H



OCF2H
2-CF3



OCF2H
2-OCF3



OCF2H
2-OCF2H



OCF2H
2-OCF2CF2H



OCF2H
2-OCH2CF3



OCF2H
2-SCF3



OCF2H
2-SOCF3



OCF2H
2-SO2CF3



OCF2H
2-SCF2H



OCF2H
2-SOCF2H



OCF2H
2-SO2CF2H



OCF2H
3-CF3



OCF2H
3-OCF3



OCF2H
3-OCF2H



OCF2H
3-OCF2CF3H



OCF2H
3-OCH2CF3



OCF2H
3-SCF3



OCF2H
3-SOCF3



OCF2H
3-SO2CF3



OCF2H
3-SCF2H



OCF2H
3-SOCF2H



OCF2H
3-SO2CF2H



OCF2H
4-CF3



OCF2H
4-OCF3



OCF2H
4-OCF2H



OCF2H
4-OCF2CF3H



OCF2H
4-OCH2CF3



OCF2H
4-SCF3



OCF2H
4-SOCF3



OCF2H
4-SO2CF3



OCF2H
4-SCF2H



OCF2H
4-SOCF2H



OCF2H
4-SO2CF2H



Me
2-Me-4-CF3



Me
2-Me-4-OCF3



Me
2-Me-4-OCF2H



Me
2-Me-4-OCH2CF3



Me
2-Me-4-SCF3



Me
2-Me-4-SOCF3



Me
2-Me-4-SO2CF3



Me
2-Me-4-SCF2H



Me
2-Me-4-SOCF2H



Me
2-Me-4-SO2CF2H



Br
2-Me-4-CF3



Br
2-Me-4-OCF3



Br
2-Me-4-OCF2H



Br
2-Me-4-OCH2CF3



Br
2-Me-4-SCF3



Br
2-Me-4-SOCF3



Br
2-Me-4-SO2CF3



Br
2-Me-4-SCF2H



Br
2-Me-4-SOCF2H



Br
2-Me-4-SO2CF2H



CF3
2-Me-4-CF3



CF3
2-Me-4-OCF3



CF3
2-Me-4-OCF2H



CF3
2-Me-4-OCH2CF3



CF3
2-Me-4-SCF3



CF3
2-Me-4-SOCF3



CF3
2-Me-4-SO2CF3



CF3
2-Me-4-SCF2H



CF3
2-Me-4-SOCF2H



CF3
2-Me-4-SO2CF2H



F
2-Me-4-CF3



F
2-Me-4-OCF3



F
2-Me-4-OCF2H



F
2-Me-4-OCH2CF3



F
2-Me-4-SCF3



F
2-Me-4-SOCF3



F
2-Me-4-SO2CF3



F
2-Me-4-SCF2H



F
2-Me-4-SOCF2H



F
2-Me-4-SO2CF2H



I
2-Me-4-CF3



I
2-Me-4-OCF3



I
2-Me-4-OCF2H



I
2-Me-4-OCH2CF3



I
2-Me-4-SCF3



I
2-Me-4-SOCF3



I
2-Me-4-SO2CF3



I
2-Me-4-SCF2H



I
2-Me-4-SOCF2H



I
2-Me-4-SO2CF2H



NO2
2-Me-4-CF3



NO2
2-Me-4-OCF3



NO2
2-Me-4-OCF2H



NO2
2-Me-4-OCH2CF3



NO2
2-Me-4-SCF3



NO2
2-Me-4-SOCF3



NO2
2-Me-4-SO2CF3



NO2
2-Me-4-SCF2H



NO2
2-Me-4-SOCF2H



NO2
2-Me-4-SO2CF2H



Cl
2-Me-4-CF3



Cl
2-Me-4-OCF3



Cl
2-Me-4-OCF2H



Cl
2-Me-4-OCH2CF3



Cl
2-Me-4-SCF3



Cl
2-Me-4-SOCF3



Cl
2-Me-4-SO2CF3



Cl
2-Me-4-SCF2H



Cl
2-Me-4-SOCF2H



Cl
2-Me-4-SO2CF2H



OMe
2-Me-4-CF3



OMe
2-Me-4-OCF3



OMe
2-Me-4-OCF2H



OMe
2-Me-4-OCH2CF3



OMe
2-Me-4-SCF3



OMe
2-Me-4-SOCF3



OMe
2-Me-4-SO2CF3



OMe
2-Me-4-SCF2H



OMe
2-Me-4-SOCF2H



OMe
2-Me-4-SO2CF2H



SMe
2-Me-4-CF3



SMe
2-Me-4-OCF3



SMe
2-Me-4-OCF2H



SMe
2-Me-4-OCH2CF3



SMe
2-Me-4-SCF3



SMe
2-Me-4-SOCF3



SMe
2-Me-4-SO2CF3



SMe
2-Me-4-SCF2H



SMe
2-Me-4-SOCF2H



SMe
2-Me-4-SO2CF2H

















TABLE 15













 














K
R3
(R4)n
R5
W
X
Y
Z





K-1
i-Pr
4-Me
CF3
CMe
N
CH
CH


K-1
i-Pr
4-Cl
CF3
CMe
N
CH
CH


K-18
i-Pr
4-Me
CF3
CMe
N
CH
CH


K-18
i-Pr
4-Cl
CF3
CMe
N
CH
CH


K-14
i-Pr
1-Me
CF3
CMe
N
CH
CH


K-28
i-Pr
4-Me
CF3
CMe
N
CH
CH


K-28
i-Pr
4-Cl
CF3
CMe
N
CH
CH


K-30
i-Pr
5-Me
CF3
CMe
N
CH
CH


K-30
i-Pr
5-Cl
CF3
CMe
N
CH
CH


K-31
i-Pr
2-Me
CF3
CMe
N
CH
CH


K-31
i-Pr
2-Cl
CF3
CMe
N
CH
CH


K-33
i-Pr
6-Me
CF3
CMe
N
CH
CH


K-33
i-Pr
6-Cl
CF3
CMe
N
CH
CH


K-1
i-Pr
4-Me
CF3
CMe
CH
N
CH


K-1
i-Pr
4-Cl
CF3
CMe
CH
N
CH


K-18
i-Pr
4-Me
CF3
CMe
CH
N
CH


K-18
i-Pr
4-Cl
CF3
CMe
CH
N
CH


K-14
i-Pr
1-Me
CF3
CMe
CH
N
CH


K-28
i-Pr
4-Me
CF3
CMe
CH
N
CH


K-28
i-Pr
4-Cl
CF3
CMe
CH
N
CH


K-30
i-Pr
5-Me
CF3
CMe
CH
N
CH


K-30
i-Pr
5-Cl
CF3
CMe
CH
N
CH


K-31
i-Pr
2-Me
CF3
CMe
CH
N
CH


K-31
i-Pr
2-Cl
CF3
CMe
CH
N
CH


K-33
i-Pr
6-Me
CF3
CMe
CH
N
CH


K-33
i-Pr
6-Cl
CF3
CMe
CH
N
CH


K-1
i-Pr
4-Me
CF3
CMe
CH
N
CH


K-1
i-Pr
4-Cl
CF3
CMe
CH
N
CH


K-18
i-Pr
4-Me
CF3
CMe
CH
N
CH


K-18
i-Pr
4-Cl
CF3
CMe
CH
N
CH


K-14
i-Pr
1-Me
CF3
CMe
CH
N
CH


K-28
i-Pr
4-Me
CF3
CMe
CH
CH
N


K-28
i-Pr
4-Cl
CF3
CMe
CH
CH
N


K-30
i-Pr
5-Me
CF3
CMe
CH
CH
N


K-30
i-Pr
5-Cl
CF3
CMe
CH
CH
N


K-31
i-Pr
2-Me
CF3
CMe
CH
CH
N


K-31
i-Pr
2-Cl
CF3
CMe
CH
CH
N


K-33
i-Pr
6-Me
CF3
CMe
CH
CH
N


K-33
i-Pr
6-Cl
CF3
CMe
CH
CH
N


K-1
t-Bu
4-Me
CF3
CMe
N
CH
CH


K-1
t-Bu
4-Cl
CF3
CMe
N
CH
CH


K-18
t-Bu
4-Me
CF3
CMe
N
CH
CH


K-18
t-Bu
4-Cl
CF3
CMe
N
CH
CH


K-14
t-Bu
1-Me
CF3
CMe
N
CH
CH


K-28
t-Bu
4-Me
CF3
CMe
N
CH
CH


K-28
t-Bu
4-Cl
CF3
CMe
N
CH
CH


K-30
t-Bu
5-Me
CF3
CMe
N
CH
CH


K-30
t-Bu
5-Cl
CF3
CMe
N
CH
CH


K-31
t-Bu
2-Me
CF3
CMe
N
CH
CH


K-31
t-Bu
2-Cl
CF3
CMe
N
CH
CH


K-33
t-Bu
6-Me
CF3
CMe
N
CH
CH


K-33
t-Bu
6-Cl
CF3
CMe
N
CH
CH


K-1
t-Bu
4-Me
CF3
CMe
CH
N
CH


K-1
t-Bu
4-Cl
CF3
CMe
CH
N
CH


K-18
t-Bu
4-Me
CF3
CMe
CH
N
CH


K-18
t-Bu
4-Cl
CF3
CMe
CH
N
CH


K-14
t-Bu
1-Me
CF3
CMe
CH
N
CH


K-28
t-Bu
4-Me
CF3
CMe
CH
N
CH


K-28
t-Bu
4-Cl
CF3
CMe
CH
N
CH


K-30
t-Bu
5-Me
CF3
CMe
CH
N
CH


K-30
t-Bu
5-Cl
CF3
CMe
CH
N
CH


K-31
t-Bu
2-Me
CF3
CMe
CH
N
CH


K-31
t-Bu
2-Cl
CF3
CMe
CH
N
CH


K-33
t-Bu
6-Me
CF3
CMe
CH
N
CH


K-33
t-Bu
6-Cl
CF3
CMe
CH
N
CH


K-1
t-Bu
4-Me
CF3
CMe
CH
N
CH


K-1
t-Bu
4-Cl
CF3
CMe
CH
N
CH


K-18
t-Bu
4-Me
CF3
CMe
CH
N
CH


K-18
t-Bu
4-Cl
CF3
CMe
CH
N
CH


K-14
t-Bu
1-Me
CF3
CMe
CH
N
CR


K-28
t-Bu
4-Me
CF3
CMe
CH
CH
N


K-28
t-Bu
4-Cl
CF3
CMe
CH
CH
N


K-30
t-Bu
5-Me
CF3
CMe
CH
CH
N


K-30
t-Bu
5-Cl
CF3
CMe
CR
CH
N


K-31
t-Bu
2-Me
CF3
CMe
CH
CH
N


K-31
t-Bu
2-Cl
CF3
CMe
CH
CR
N


K-33
t-Bu
6-Me
CF3
CMe
CR
CH
N


K-33
t-Bu
6-Cl
CF3
CMe
CR
CH
N


K-1
i-Pr
4-Me
OCF3
CMe
N
CH
CH


K-1
i-Pr
4-Cl
OCF3
CMe
N
CH
CH


K-18
i-Pr
4-Me
OCF3
CMe
N
CH
CH


K-18
i-Pr
4-Cl
OCF3
CMe
N
CH
CH


K-14
i-Pr
1-Me
OCF3
CMe
N
CH
CH


K-28
i-Pr
4-Me
OCF3
CMe
N
CH
CH


K-28
i-Pr
4-Cl
OCF3
CMe
N
CH
CH


K-30
i-Pr
5-Me
OCF3
CMe
N
CH
CH


K-30
i-Pr
5-Cl
OCF3
CMe
N
CH
CH


K-31
i-Pr
2-Me
OCF3
CMe
N
CH
CH


K-31
i-Pr
2-Cl
OCF3
CMe
N
CH
CH


K-33
i-Pr
6-Me
OCF3
CMe
N
CH
CH


K-33
i-Pr
6-Cl
OCF3
CMe
N
CH
CH


K-1
i-Pr
4-Me
OCF3
CH
N
CH
CH


K-1
i-Pr
4-Cl
OCF3
CH
N
CH
CH


K-18
i-Pr
4-Me
OCF3
CH
N
CH
CH


K-18
i-Pr
4-Cl
OCF3
CH
N
CH
CH


K-14
i-Pr
1-Me
OCF3
CH
N
CH
CH


K-28
i-Pr
4-Me
OCF3
CH
N
CH
CH


K-28
i-Pr
4-Cl
OCF3
CH
N
CH
CH


K-30
i-Pr
5-Me
OCF3
CH
N
CH
CH


K-30
i-Pr
5-Cl
OCF3
CH
N
CH
CH


K-31
i-Pr
2-Me
OCF3
CH
N
CH
CH


K-31
i-Pr
2-Cl
OCF3
CH
N
CH
CH


K-33
i-Pr
6-Me
OCF3
CH
N
CH
CH


K-33
i-Pr
6-Cl
OCF3
CH
N
CH
CH


K-1
i-Pr
4-Me
Cl
CMe
CH
CH
N


K-1
i-Pr
4-Cl
CI
CMe
CH
CH
N


K-18
i-Pr
4-Me
CI
CMe
CH
CH
N


K-18
i-Pr
4-Cl
CI
CMe
CH
CH
N


K-14
i-Pr
1-Me
Cl
CMe
CH
CH
N


K-28
i-Pr
4-Me
Cl
CMe
CH
CH
N


K-28
i-Pr
4-Cl
Cl
CMe
CH
CH
N


K-30
i-Pr
S-Me
Cl
CMe
CH
CH
N


K-30
i-Pr
5-Cl
Cl
CMe
CH
CH
N


K-31
i-Pr
2-Me
Cl
CMe
CH
CH
N


K-31
i-Pr
2-Cl
Cl
OMe
CH
CH
N


K-33
i-Pr
6-Me
Cl
CMe
CH
CH
N


K-33
i-Pr
6-Cl
Cl
CMe
CH
CH
N
















TABLE 16













 














K
(R4)n
Q
X
Y
Z











R3 is i-Pr














K-1
4-Me
NCHF2
CMe
N
CH



K-1
4-Cl
NCHF2
CMe
N
CH



K-18
4-Me
NCHF2
CMe
N
CH



K-18
4-Cl
NCHF2
CMe
N
CH



K-14
1-Me
NCHF2
CMe
N
CH



K-28
4-Me
NCHF2
CMe
N
CH



K-28
4-Cl
NCHF2
CMe
N
CH



K-30
S-Me
NCHF2
CMe
N
CH



K-30
5-Cl
NCHF2
CMe
N
CH







R3 is i-Pr














K-31
2-Me
NCHF2
CMe
N
CH



K-31
2-Cl
NCHF2
CMe
N
CH



K-33
6-Me
NCHF2
CMe
N
CH



K-33
6-Cl
NCHF2
CMe
N
CH



K-1
4-Me
NCHF2
CH
N
CMe



K-1
4-Cl
NCHF2
CH
N
CMe



K-18
4-Me
NCHF2
CH
N
CMe



K-18
4-Cl
NCHF2
CH
N
CMe



K-14
1-Me
NCHF2
CH
N
CMe



K-28
4-Me
NCHF2
CH
N
CMe



K-28
4-Cl
NCHF2
CH
N
CMe



K-30
5-Me
NCHF2
CH
N
CMe



K-30
5-Cl
NCHF2
CH
N
CMe



K-31
2-Me
NCHF2
CH
N
CMe



K-31
2-Cl
NCHF2
CH
N
CMe



K-33
6-Me
NCHF2
CH
N
CMe



K-33
6-Cl
NCHF2
CH
N
CMe



K-1
4-Me
NCF2CHF2
CMe
N
CH



K-1
4-Cl
NCF2CHF2
CMe
N
CM



K-18
4-Me
NCF2CHF2
CMe
N
CH



K-18
4-Cl
NCF2CHF2
CMe
N
CH



K-14
1-Me
NCF2CHF2
CMe
N
CH



K-28
4-Me
NCF2CHF2
CMe
N
CH



K-28
4-Cl
NCF2CHF2
CMe
N
CM



K-30
5-Me
NCF2CHF2
CMe
N
CH



K-30
5-Cl
NCF2CHF2
CMe
N
CH



K-31
2-Me
NCF2CHF2
CMe
N
CM



K-31
2-Cl
NCF2CHF2
CMe
N
CM



K-33
6-Me
NCF2CHF2
CMe
N
CH



K-33
6-Cl
NCF2CHF2
CMe
N
CH



K-1
4-Me
NCH2CF3
CMe
N
CH



K-1
4-Cl
NCH2CF3
CMe
N
CH



K-18
4-Me
NCH2CF3
CMe
N
CH



K-18
4-Cl
NCH2CF3
CMe
N
CH



K-14
1-Me
NCH2CF3
CMe
N
CH



K-28
4-Me
NCH2CF3
CMe
N
CH







R3 is i-Pr














K-28
4-Cl
NCH2CF3
CMe
N
CH



K-30
5-Me
NCH2CF3
CMe
N
CH



K-30
S-Cl
NCH2CF3
CMe
N
CH



K-31
2-Me
NCH2CF3
CMe
N
CH



K-31
2-Cl
NCH2CF3
CMe
N
CH



K-33
6-Me
NCH2CF3
CMe
N
CH



K-33
6-Cl
NCH2CF3
CMe
N
CH



K-1
4-Me
NCF2CF3
CH
N
CMe



K-1
4-Cl
NCH2CF3
CH
N
CMe



K-18
4-Me
NCH2CF3
CH
N
CMe



K-18
4-Cl
NCH2CF3
CH
N
CMe



K-14
1-Me
NCH2CF3
CH
N
CMe



K-28
4-Me
NCH2CF3
CH
N
CMe



K-28
4-Cl
NCH2CF3
CH
N
CMe



K-30
S-Me
NCH2CF3
CH
N
CMe



K-30
5-Cl
NCH2CF3
CH
N
CMe



K-31
2-Me
NCH2CF3
CH
N
CMe



K-31
2-Cl
NCH2CF3
CH
N
CMe



K-33
6-Me
NCH2CF3
CH
N
CMe



K-33
6-Cl
NCH2CF3
CH
N
CMe



K-1
4-Me
NCF2CHF2
N
CH
CMe



K-1
4-Cl
NCF2CHF2
N
CH
CMe



K-18
4-Me
NCF2CHF2
N
CH
CMe



K-18
4-Cl
NCF2CHF2
N
CH
CMe



K-14
1-Me
NCF2CHF2
N
CH
CMe



K-28
4-Me
NCF2CHF2
N
CH
CMe



K-28
4-Cl
NCF2CHF2
N
CH
CMe



K-30
5-Me
NCF2CHF2
N
CH
CMe



K-30
5-Cl
NCF2CHF2
N
CH
CMe



K-31
2-Me
NCF2CHF2
N
CH
CMe



K-31
2-Cl
NCF2CHF2
N
CH
CMe



K-33
6-Me
NCF2CHF2
N
CH
CMe



K-33
6-Cl
NCF2CHF2
N
CH
CMe







R3 is t-Bu














K-1
4-Me
NCHF2
CMe
N
CH



K-1
4-Cl
NCHF2
CMe
N
CH



K-18
4-Me
NCHF2
CMe
N
CH



K-18
4-Cl
NCHF2
CMe
N
CH



K-14
1-Me
NCHF2
CMe
N
CH



K-28
4-Me
NCHF2
CMe
N
CH



K-28
4-Cl
NCHF2
CMe
N
CH



K-30
5-Me
NCHF2
CMe
N
CH



K-30
5-Cl
NCHF2
CMe
N
CH



K-31
2-Me
NCHF2
CMe
N
CH



K-31
2-Cl
NCHF2
CMe
N
CH



K-33
6-Me
NCHF2
CMe
N
CH



K-33
6-Cl
NCHF2
CMe
N
CH



K-1
4-Me
NCHF2
CH
N
CMe



K-1
4-Cl
NCHF2
CH
N
CMe



K-18
4-Me
NCHF2
CH
N
CMe



K-18
4-Cl
NCHF2
CH
N
CMe



K-14
1-Me
NCHF2
CH
N
CMe



K-28
4-Me
NCHF2
CH
N
CMe



K-28
4-Cl
NCHF2
CH
N
CMe



K-30
5-Me
NCHF2
CH
N
CMe



K-30
5-Cl
NCHF2
CH
N
CMe



K-31
2-Me
NCHF2
CH
N
CMe



K-31
2-Cl
NCHF2
CH
N
CMe



K-33
6-Me
NCHF2
CH
N
CMe



K-33
6-Cl
NCHF2
CH
N
CMe



K-1
4-Me
NCF2CHF2
CMe
N
CH



K-1
4-Cl
NCF2CHF2
CMe
N
CH



K-18
4-Me
NCF2CHF2
CMe
N
CH



K-18
4-Cl
NCF2CHF2
CMe
N
CH



K-14
1-Me
NCF2CHF2
CMe
N
CH



K-25
4-Me
NCF2CHF2
CMe
N
CH



K-25
4-Cl
NCF2CHF2
CMe
N
CH



K-30
5-Me
NCF2CHF2
CMe
N
CH



K-30
5-Cl
NCF2CHF2
CMe
N
CH



K-31
2-Me
NCF2CHF2
CMe
N
CH







R3 is t-Bu














K-31
2-Cl
NCF2CHF2
CMe
N
CH



K-33
6-Me
NCF2CHF2
CMe
N
CH



K-33
6-Cl
NCF2CHF2
CMe
N
CH



K-1
4-Me
NCH2CF3
CMe
N
CH



K-1
4-Cl
NCH2CF3
CMe
N
CH



K-18
4-Me
NCH2CF3
CMe
N
CH



K-18
4-Cl
NCH2CF3
CMe
N
CH



K-14
1-Me
NCH2CF3
CMe
N
CH



K-28
4-Me
NCH2CF3
CMe
N
CH



K-28
4-Cl
NCH2CF3
CMe
N
CH



K-30
5-Me
NCH2CF3
CMe
N
CH



K-30
5-Cl
NCH2CF3
CMe
N
CH



K-31
2-Me
NCH2CF3
CMe
N
CH



K-31
2-Cl
NCH2CF3
CMe
N
CH



K-33
6-Me
NCH2CF3
CMe
N
CH



K-33
6-Cl
NCH2CF3
CMe
N
CH



K-1
4-Me
NCH2CF3
CH
N
CMe



K-1
4-Cl
NCH2CF3
CH
N
CMe



K-18
4-Me
NCH2CF3
CH
N
CMe



K-18
4-Cl
NCH2CF3
CH
N
CMe



K-14
1-Me
NCH2CF3
CH
N
CMe



K-28
4-Me
NCH2CF3
CH
N
CMe



K-28
4-Cl
NCH2CF3
CH
N
CMe



K-30
5-Me
NCH2CF3
CH
N
CMe



K-30
5-Cl
NCH2CF3
CH
N
CMe



K-31
2-Me
NCH2CF3
CH
N
CMe



K-31
2-Cl
NCH2CF3
CH
N
CMe



K-33
6-Me
NCH2CF3
CH
N
CMe



K-33
6-Cl
NCH2CF3
CH
N
CMe



K-1
4-Me
NCF2CHF2
N
CH
CMe



K-1
4-Cl
NCF2CHF2
N
CH
CMe



K-18
4-Me
NCF2CHF2
N
CH
CMe



K-18
4-Cl
NCF2CHF2
N
CH
CMe



K-14
1-Me
NCF2CHF2
N
CH
CMe



K-28
4-Me
NCF2CHF2
N
CH
CMe



K-28
4-Cl
NCF2CHF2
N
CH
CMe







R3 is t-Bu














K-30
5-Me
NCF2CHF2
N
CH
CMe



K-30
5-Cl
NCF2CHF2
N
CH
CMe



K-31
2-Me
NCF2CHF2
N
CH
CMe



K-31
2-Cl
NCF2CHF2
N
CH
CMe



K-33
6-Me
NCF2CHF2
N
CH
CMe



K-33
6-Cl
NCF2CHF2
N
CH
CMe

















TABLE 17













 















K
W
X
Y
Z
R3
(R4)n
R5
R6





K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
Me


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
Me


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Me


K-1
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Me


K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
F


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
F


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
F


K-1
CH
CH
CH
CH
t-Bu
4-Cl
CF3
F


K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
Cl


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
Cl


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Cl


K-1
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Cl


K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
Br


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
Br


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Br


K-1
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Br


K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
CN


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
CN


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
CN


K-1
CH
CH
CH
CH
t-Bu
4-Cl
CF3
CN


K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
Me


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
Me


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Me


K-1
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Me


K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
F


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
F


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
F


K-1
CH
CH
CH
CH
t-Bu
4-Cl
CF3
F


K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
Cl


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
Cl


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Cl


K-1
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Cl


K-1
CH
CH
CH
CH
i-Pr
4-Me
CF3
Br


K-1
CH
CH
CH
CH
t-Bu
4-Me
CF3
Br


K-1
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Br


K-1
CH
CH
CH
N
t-Bu
4-Cl
CF3
Br


K-1
CH
CH
CH
N
i-Pr
4-Me
CF3
CN


K-1
CH
CH
CH
N
t-Bu
4-Me
CF3
CN


K-1
CH
CH
CH
N
i-Pr
4-Cl
CF3
CN


K-1
CH
CH
CH
N
i-Pr
4-Cl
CF3
CN


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
Me


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
Me


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Me


K-18
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Me


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
F


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
F


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
F


K-18
CH
CH
CH
CH
t-Bu
4-Cl
CF3
F


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
Cl


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
Cl


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Cl


K-18
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Cl


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
Br


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
Br


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Br


K-18
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Br


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
CN


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
CN


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
CN


K-18
CH
CH
CH
CH
t-Bu
4-Cl
CF3
CN


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
Me


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
Me


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Me


K-18
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Me


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
F


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
F


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
F


K-18
CH
CH
CH
CH
t-Bu
4-Cl
CF3
F


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
Cl


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
Cl


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Cl


K-18
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Cl


K-18
CH
CH
CH
CH
i-Pr
4-Me
CF3
Br


K-18
CH
CH
CH
CH
t-Bu
4-Me
CF3
Br


K-18
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Br


K-18
CH
CH
CH
N
t-Bu
4-Cl
CF3
Br


K-18
CH
CH
CH
N
i-Pr
4-Me
CF3
CN


K-18
CH
CH
CH
N
t-Bu
4-Me
CF3
CN


K-18
CH
CH
CH
N
i-Pr
4-Cl
CF3
CN


K-18
CH
CH
CH
N
i-Pr
4-Cl
CF3
CN


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
Me


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
Me


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
F


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
F


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
Cl


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
Cl


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
Br


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
Br


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
CN


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
CN


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
Me


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
Me


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
F


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
F


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
Cl


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
Cl


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
Br


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
Br


K-14
CH
CH
CH
CH
i-Pr
1-Me
CF3
CN


K-14
CH
CH
CH
CH
t-Bu
1-Me
CF3
CN


K-28
CH
CH
CH
CH
i-Pr
4-Me
CF3
Me


K-28
CH
CH
CH
CH
t-Bu
4-Me
CF3
Me


K-28
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Me


K-28
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Me


K-28
CH
CH
CH
CH
i-Pr
4-Me
CF3
F


K-28
CH
CH
CH
CH
t-Bu
4-Me
CF3
F


K-28
CH
CH
CH
CH
i-Pr
4-Cl
CF3
F


K-28
CH
CH
CH
CH
t-Bu
4-Cl
CF3
F


K-28
CH
CH
CH
CH
i-Pr
4-Me
CF3
Cl


K-28
CH
CH
CH
CH
t-Bu
4-Me
CF3
Cl


K-28
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Cl


K-28
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Cl


K-28
CH
CH
CH
CH
i-Pr
4-Me
CF3
Br


K-28
CH
CH
CH
CH
t-Bu
4-Me
CF3
Br


K-28
CH
CH
CH
CH
i-Pr
4-Cl
CF3
Br


K-28
CH
CH
CH
CH
t-Bu
4-Cl
CF3
Br


K-28
CH
CH
CH
CH
i-Pr
4-Me
CF3
CN


K-28
CH
CH
CH
CH
t-Bu
4-Me
CF3
CN


K-28
CH
CH
CH
CH
i-Pr
4-Cl
CF3
CN


K-28
CH
CH
CH
CH
t-Bu
4-Cl
CF3
CN


K-28
CH
CH
CH
N
i-Pr
4-Me
CF3
Me


K-28
CH
CH
CH
N
t-Bu
4-Me
CF3
Me


K-28
CH
CH
CH
N
i-Pr
4-Cl
CF3
Me


K-28
CH
CH
CH
N
t-Bu
4-Cl
CF3
Me


K-28
CH
CH
CH
N
i-Pr
4-Me
CF3
F


K-28
CH
CH
CH
N
t-Bu
4-Me
CF3
F


K-28
CH
CH
CH
N
i-Pr
4-Cl
CF3
F


K-28
CH
CH
CH
N
t-Bu
4-Cl
CF3
F


K-28
CH
CH
CH
N
i-Pr
4-Me
CF3
Cl


K-28
CH
CH
CH
N
t-Bu
4-Me
CF3
Cl


K-28
CH
CH
CH
N
i-Pr
4-Cl
CF3
Cl


K-28
CH
CH
CH
N
t-Bu
4-Cl
CF3
Cl


K-28
CH
CH
CH
N
i-Pr
4-Me
CF3
Br


K-28
CH
CH
CH
N
t-Bu
4-Me
CF3
Br


K-28
CH
CH
CH
N
i-Pr
4-Cl
CF3
Br


K-28
CH
CH
CH
N
t-Bu
4-Cl
CF3
Br


K-28
CH
CH
CH
N
i-Pr
4-Me
CF3
CN


K-28
CH
CH
CH
N
t-Bu
4-Me
CF3
CN


K-28
CH
CH
CH
N
i-Pr
4-Cl
CF3
CN


K-28
CH
CH
CH
N
i-Pr
4-Cl
CF3
CN


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
Me


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
Me


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
Me


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
Me


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
F


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
F


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
F


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
F


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
Cl


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
Cl


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
Cl


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
Cl


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
Br


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
Br


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
Br


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
Br


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
CN


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
CN


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
CN


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
CN


K-30
CH
CH
CH
N
i-Pr
Me
CF3
Me


K-30
CH
CH
CH
N
t-Bu
Me
CF3
Me


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
Me


K-30
CH
CH
CH
N
t-Bu
5-Cl
CF3
Me


K-30
CH
CH
CH
N
i-Pr
Me
CF3
F


K-30
CH
CH
CH
N
t-Bu
Me
CF3
F


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
F


K-30
CH
CH
CH
N
t-Bu
5-Cl
CF3
F


K-30
CH
CH
CH
N
i-Pr
Me
CF3
Cl


K-30
CH
CH
CH
N
t-Bu
Me
CF3
Cl


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
Cl


K-30
CH
CH
CH
N
t-Bu
5-Cl
CF3
Cl


K-30
CH
CH
CH
N
i-Pr
Me
CF3
Br


K-30
CH
CH
CH
N
t-Bu
Me
CF3
Br


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
Br


K-30
CH
CH
CH
N
t-Bu
5-Cl
CF3
Br


K-30
CH
CH
CH
N
i-Pr
Me
CF3
CN


K-30
CH
CH
CH
N
t-Bu
Me
CF3
CN


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
CN


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
CN


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
Me


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
Me


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
Me


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
Me


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
F


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
F


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
F


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
F


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
Cl


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
Cl


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
Cl


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
Cl


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
Br


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
Br


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
Br


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
Br


K-30
CH
CH
CH
CH
i-Pr
Me
CF3
CN


K-30
CH
CH
CH
CH
t-Bu
Me
CF3
CN


K-30
CH
CH
CH
CH
i-Pr
5-Cl
CF3
CN


K-30
CH
CH
CH
CH
t-Bu
5-Cl
CF3
CN


K-30
CH
CH
CH
N
i-Pr
Me
CF3
Me


K-30
CH
CH
CH
N
t-Bu
Me
CF3
Me


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
Me


K-30
CH
CH
CH
N
t-Bu
5-Cl
CF3
Me


K-30
CH
CH
CH
N
i-Pr
Me
CF3
F


K-30
CH
CH
CH
N
t-Bu
Me
CF3
F


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
F


K-30
CH
CH
CH
N
t-Bu
5-Cl
CF3
F


K-30
CH
CH
CH
N
i-Pr
Me
CF3
Cl


K-30
CH
CH
CH
N
t-Bu
Me
CF3
Cl


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
Cl


K-30
CH
CH
CH
N
t-Bu
5-Cl
CF3
Cl


K-30
CH
CH
CH
N
i-Pr
Me
CF3
Br


K-30
CH
CH
CH
N
t-Bu
Me
CF3
Br


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
Br


K-30
CH
CH
CH
N
t-Bu
5-Cl
CF3
Br


K-30
CH
CH
CH
N
i-Pr
Me
CF3
CN


K-30
CH
CH
CH
N
t-Bu
Me
CF3
CN


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
CN


K-30
CH
CH
CH
N
i-Pr
5-Cl
CF3
CN


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
Me


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
Me


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
Me


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
Me


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
F


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
F


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
F


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
F


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
Cl


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
Cl


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
Cl


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
Cl


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
Br


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
Br


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
Br


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
Br


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
CN


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
CN


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
CN


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
CN


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
Me


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
Me


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
Me


K-31
CH
CH
CH
N
t-Bu
2-Cl
CF3
Me


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
F


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
F


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
F


K-31
CH
CH
CH
N
t-Bu
2-Cl
CF3
F


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
Cl


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
Cl


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
Cl


K-31
CH
CH
CH
N
t-Bu
2-Cl
CF3
Cl


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
Br


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
Br


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
Br


K-31
CH
CH
CH
N
t-Bu
2-Cl
CF3
Br


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
CN


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
CN


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
CN


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
CN


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
Me


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
Me


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
Me


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
Me


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
F


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
F


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
F


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
F


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
Cl


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
Cl


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
Cl


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
Cl


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
Br


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
Br


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
Br


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
Br


K-31
CH
CH
CH
CH
i-Pr
2-Me
CF3
CN


K-31
CH
CH
CH
CH
t-Bu
2-Me
CF3
CN


K-31
CH
CH
CH
CH
i-Pr
2-Cl
CF3
CN


K-31
CH
CH
CH
CH
t-Bu
2-Cl
CF3
CN


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
Me


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
Me


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
Me


K-31
CH
CH
CH
N
t-Bu
2-Cl
CF3
Me


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
F


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
F


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
F


K-31
CH
CH
CH
N
t-Bu
2-Cl
CF3
F


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
Cl


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
Cl


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
Cl


K-31
CH
CH
CH
N
t-Bu
2-Cl
CF3
Cl


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
Br


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
Br


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
Br


K-31
CH
CH
CH
N
t-Bu
2-Cl
CF3
Br


K-31
CH
CH
CH
N
i-Pr
2-Me
CF3
CN


K-31
CH
CH
CH
N
t-Bu
2-Me
CF3
CN


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
CN


K-31
CH
CH
CH
N
i-Pr
2-Cl
CF3
CN


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
Me


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
Me


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
Me


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
Me


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
F


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
F


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
F


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
F


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
Cl


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
Cl


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
Cl


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
Cl


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
Br


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
Br


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
Br


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
Br


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
CN


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
CN


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
CN


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
CN


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
Me


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
Me


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
Me


K-33
CH
CH
CH
N
t-Bu
6-Cl
CF3
Me


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
F


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
F


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
F


K-33
CH
CH
CH
N
t-Bu
6-Cl
CF3
F


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
Cl


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
Cl


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
Cl


K-33
CH
CH
CH
N
t-Bu
6-Cl
CF3
Cl


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
Br


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
Br


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
Br


K-33
CH
CH
CH
N
t-Bu
6-Cl
CF3
Br


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
CN


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
CN


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
CN


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
CN


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
Me


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
Me


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
Me


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
Me


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
F


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
F


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
F


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
F


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
Cl


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
Cl


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
Cl


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
Cl


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
Br


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
Br


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
Br


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
Br


K-33
CH
CH
CH
CH
i-Pr
6-Me
CF3
CN


K-33
CH
CH
CH
CH
t-Bu
6-Me
CF3
CN


K-33
CH
CH
CH
CH
i-Pr
6-Cl
CF3
CN


K-33
CH
CH
CH
CH
t-Bu
6-Cl
CF3
CN


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
Me


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
Me


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
Me


K-33
CH
CH
CH
N
t-Bu
6-Cl
CF3
Me


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
F


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
F


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
F


K-33
CH
CH
CH
N
t-Bu
6-Cl
CF3
F


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
Cl


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
Cl


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
Cl


K-33
CH
CH
CH
N
t-Bu
6-Cl
CF3
Cl


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
Br


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
Br


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
Br


K-33
CH
CH
CH
N
t-Bu
6-Cl
CF3
Br


K-33
CH
CH
CH
N
i-Pr
6-Me
CF3
CN


K-33
CH
CH
CH
N
t-Bu
6-Me
CF3
CN


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
CN


K-33
CH
CH
CH
N
i-Pr
6-Cl
CF3
CN
















TABLE 18













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5 is Cl


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Br


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is Br


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is OCH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 19













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5 is CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Br


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CF2CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 20













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5 is Cl


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Br


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is Br


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is OCH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 21













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5 is CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Br


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CF2CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is OCH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
CH3


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 22













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5 is Cl


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is Br


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is OCH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 23













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5 is CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CF2CF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 24













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5 is Cl


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is Br


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is OCH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 25













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4
R5
R6
R4
R5
R6
R4
R5
R6
R4
R5
R6










V is CH


















Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Br
CN
Cl
Br
CN
Cl
Br
CN
Cl
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN


Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br


Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Br
CN
Br
Br
CN
Br
Br
CN
Br
Br
CN


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Br
Br


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Br
Br


Br
Cl
CN
Br
Cl
CN
Br
Cl
CN
Cl
Br
CN


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Cl
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Cl
CF3
Br


Br
CF3
CN
Br
CF3
CN
Br
CF3
CN
Cl
CF3
CN


Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Br
OCH2CF3
Br
Br
OCH2CF3
Br
Br
OCH2CF3
Br
Cl
OCH2CF3
Br


Br
OCH2CF3
CN
Br
OCH2CF3
CN
Br
OCH2CF3
CN
Cl
OCH2CF3
CN


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Br
CN
CH3
Br
CN
CH3
Br
CN
CH3
Br
CN


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Br
Br


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Br
Br


CH3
Cl
CN
CH3
Cl
CN
CH3
Cl
CN
CH3
Br
CN


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN


CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl


CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br


CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN


CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl


CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br


CF3
Br
CN
CF3
Br
CN
CF3
Br
CN
CF3
Br
CN


CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Br
Br


CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Br
Br


CF3
Cl
CN
CF3
Cl
CN
CF3
Cl
CN
CF3
Br
CN


CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl


CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br


CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN


CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl


CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br


CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN







V is N


















Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Br
CN
Cl
Br
CN
Cl
Br
CN
Cl
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN


Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br


Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Cl
Br
Br


Br
Br
CN
Br
Br
CN
Br
Br
CN
Cl
Br
CN


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Br
Br


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Br
Br


Br
Cl
CN
Br
Cl
CN
Br
Cl
CN
Cl
Br
CN


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Cl
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Cl
CF3
Br


Br
CF3
CN
Br
CF3
CN
Br
CF3
CN
Cl
CF3
CN


Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Br
OCH2CF3
Br
Br
OCH2CF3
Br
Br
OCH2CF3
Br
Cl
OCH2CF3
Br


Br
OCH2CF3
CN
Br
OCH2CF3
CN
Br
OCH2CF3
CN
Cl
OCH2CF3
CN


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Br
CN
CH3
Br
CN
CH3
Br
CN
CH3
Br
CN


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Br
Br


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Br
Br


CH3
Cl
CN
CH3
Cl
CN
CH3
Cl
CN
CH3
Br
CN


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN


CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl


CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br


CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN


CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl


CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br


CF3
Br
CN
CF3
Br
CN
CF3
Br
CN
CF3
Br
CN


CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Br
Br


CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Br
Br


CF3
Cl
CN
CF3
Cl
CN
CF3
Cl
CN
CF3
Br
CN


CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl


CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br


CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN


CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl


CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br


CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
















TABLE 26













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4
R5
R6
R4
R5
R6
R4
R5
R6
R4
R5
R6










V is CH


















Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Br
CN
Cl
Br
CN
Cl
Br
CN
Cl
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN


Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br


Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Cl
Br
Br


Br
Br
CN
Br
Br
CN
Br
Br
CN
Cl
Br
CN


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Br
Br


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Br
Br


Br
Cl
CN
Br
Cl
CN
Br
Cl
CN
Cl
Br
CN


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Cl
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Cl
CF3
Br


Br
CF3
CN
Br
CF3
CN
Br
CF3
CN
Cl
CF3
CN


Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Br
OCH2CF3
Br
Br
OCH2CF3
Br
Br
OCH2CF3
Br
Cl
OCH2CF3
Br


Br
OCH2CF3
CN
Br
OCH2CF3
CN
Br
OCH2CF3
CN
Cl
OCH2CF3
CN


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Br
CN
CH3
Br
CN
CH3
Br
CN
CH3
Br
CN


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Br
Br


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Br
Br


CH3
Cl
CN
CH3
Cl
CN
CH3
Cl
CN
CH3
Br
CN


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN


CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl


CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br


CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN


CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl


CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br


CF3
Br
CN
CF3
Br
CN
CF3
Br
CN
CF3
Br
CN


CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Br
Br


CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Br
Br


CF3
Cl
CN
CF3
Cl
CN
CF3
Cl
CN
CF3
Br
CN


CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl


CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br


CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN


CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl


CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br


CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN







V is N


















Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Br
CN
Cl
Br
CN
Cl
Br
CN
Cl
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN


Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br


Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Cl
Br
Br


Br
Br
CN
Br
Br
CN
Br
Br
CN
Cl
Br
CN


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Br
Br


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Br
Br


Br
Cl
CN
Br
Cl
CN
Br
Cl
CN
Cl
Br
CN


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Cl
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Cl
CF3
Br


Br
CF3
CN
Br
CF3
CN
Br
CF3
CN
Cl
CF3
CN


Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Br
OCH2CF3
Br
Br
OCH2CF3
Br
Br
OCH2CF3
Br
Cl
OCH2CF3
Br


Br
OCH2CF3
CN
Br
OCH2CF3
CN
Br
OCH2CF3
CN
Cl
OCH2CF3
CN


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Br
CN
CH3
Br
CN
CH3
Br
CN
CH3
Br
CN


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Br
Br


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Br
Br


CH3
Cl
CN
CH3
Cl
CN
CH3
Cl
CN
CH3
Br
CN


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN


CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl


CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br


CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN


CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl


CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br


CF3
Br
CN
CF3
Br
CN
CF3
Br
CN
CF3
Br
CN


CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Br
Br


CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Br
Br


CF3
Cl
CN
CF3
Cl
CN
CF3
Cl
CN
CF3
Br
CN


CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl


CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br


CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN


CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl


CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br


CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
















TABLE 27













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4
R5
R6
R4
R5
R6
R4
R5
R6
R4
R5
R6










V is CH


















Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Br
CN
Cl
Br
CN
Cl
Br
CN
Cl
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN


Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br


Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Cl
Br
Br


Br
Br
CN
Br
Br
CN
Br
Br
CN
Cl
Br
CN


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Br
Br


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Br
Br


Br
Cl
CN
Br
Cl
CN
Br
Cl
CN
Cl
Br
CN


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Cl
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Cl
CF3
Br


Br
CF3
CN
Br
CF3
CN
Br
CF3
CN
Cl
CF3
CN


Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Br
OCH2CF3
Br
Br
OCH2CF3
Br
Br
OCH2CF3
Br
Cl
OCH2CF3
Br


Br
OCH2CF3
CN
Br
OCH2CF3
CN
Br
OCH2CF3
CN
Cl
OCH2CF3
CN


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Br
CN
CH3
Br
CN
CH3
Br
CN
CH3
Br
CN


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Br
Br


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Br
Br


CH3
Cl
CN
CH3
Cl
CN
CH3
Cl
CN
CH3
Br
CN


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN


CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl


CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br


CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN


CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl


CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br


CF3
Br
CN
CF3
Br
CN
CF3
Br
CN
CF3
Br
CN


CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Br
Br


CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Br
Br


CF3
Cl
CN
CF3
Cl
CN
CF3
Cl
CN
CF3
Br
CN


CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl


CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br


CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN


CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl


CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br


CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN







V is N


















Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Br
CN
Cl
Br
CN
Cl
Br
CN
Cl
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN


Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br


Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Cl
Br
Br


Br
Br
CN
Br
Br
CN
Br
Br
CN
Cl
Br
CN


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Br
Br


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Br
Br


Br
Cl
CN
Br
Cl
CN
Br
Cl
CN
Cl
Br
CN


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Cl
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Cl
CF3
Br


Br
CF3
CN
Br
CF3
CN
Br
CF3
CN
Cl
CF3
CN


Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Br
OCH2CF3
Br
Br
OCH2CF3
Br
Br
OCH2CF3
Br
Cl
OCH2CF3
Br


Br
OCH2CF3
CN
Br
OCH2CF3
CN
Br
OCH2CF3
CN
Cl
OCH2CF3
CN


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Br
CN
CH3
Br
CN
CH3
Br
CN
CH3
Br
CN


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Br
Br


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Br
Br


CH3
Cl
CN
CH3
Cl
CN
CH3
Cl
CN
CH3
Br
CN


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN


CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl


CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br


CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN


CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl


CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br


CF3
Br
CN
CF3
Br
CN
CF3
Br
CN
CF3
Br
CN


CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Br
Br


CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Br
Br


CF3
Cl
CN
CF3
Cl
CN
CF3
Cl
CN
CF3
Br
CN


CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl


CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br


CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN


CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl


CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br


CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
















TABLE 28













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4
R5
R6
R4
R5
R6
R4
R5
R6
R4
R5
R6










V is CH


















Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Br
CN
Cl
Br
CN
Cl
Br
CN
Cl
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN


Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br


Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Cl
Br
Br


Br
Br
CN
Br
Br
CN
Br
Br
CN
Cl
Br
CN


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Br
Br


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Br
Br


Br
Cl
CN
Br
Cl
CN
Br
Cl
CN
Cl
Br
CN


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Cl
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Cl
CF3
Br


Br
CF3
CN
Br
CF3
CN
Br
CF3
CN
Cl
CF3
CN


Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Br
OCH2CF3
Br
Br
OCH2CF3
Br
Br
OCH2CF3
Br
Cl
OCH2CF3
Br


Br
OCH2CF3
CN
Br
OCH2CF3
CN
Br
OCH2CF3
CN
Cl
OCH2CF3
CN


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Br
CN
CH3
Br
CN
CH3
Br
CN
CH3
Br
CN


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Br
Br


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Br
Br


CH3
Cl
CN
CH3
Cl
CN
CH3
Cl
CN
CH3
Br
CN


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN


CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl


CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br


CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN


CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl


CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br


CF3
Br
CN
CF3
Br
CN
CF3
Br
CN
CF3
Br
CN


CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Br
Br


CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Br
Br


CF3
Cl
CN
CF3
Cl
CN
CF3
Cl
CN
CF3
Br
CN


CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl


CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br


CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN


CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl


CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br


CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN







V is N


















Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Br
CN
Cl
Br
CN
Cl
Br
CN
Cl
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN
Cl
Cl
CN


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN
Cl
CF3
CN


Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br
Cl
OCH2CF3
Br


Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN
Cl
OCH2CF3
CN


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Cl
Br
Br


Br
Br
CN
Br
Br
CN
Br
Br
CN
Cl
Br
CN


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Br
Br


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Br
Br


Br
Cl
CN
Br
Cl
CN
Br
Cl
CN
Cl
Br
CN


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Cl
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Cl
CF3
Br


Br
CF3
CN
Br
CF3
CN
Br
CF3
CN
Cl
CF3
CN


Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Br
OCH2CF3
Cl
Cl
OCH2CF3
Cl


Br
OCH2CF3
Br
Br
OCH2CF3
Br
Br
OCH2CF3
Br
Cl
OCH2CF3
Br


Br
OCH2CF3
CN
Br
OCH2CF3
CN
Br
OCH2CF3
CN
Cl
OCH2CF3
CN


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Br
CN
CH3
Br
CN
CH3
Br
CN
CH3
Br
CN


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Br
Br


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Br
Br


CH3
Cl
CN
CH3
Cl
CN
CH3
Cl
CN
CH3
Br
CN


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN
CH3
CF3
CN


CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl
CH3
OCH2CF3
Cl


CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br
CH3
OCH2CF3
Br


CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN
CH3
OCH2CF3
CN


CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl


CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br


CF3
Br
CN
CF3
Br
CN
CF3
Br
CN
CF3
Br
CN


CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Br
Br


CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Br
Br


CF3
Cl
CN
CF3
Cl
CN
CF3
Cl
CN
CF3
Br
CN


CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl
CF3
CF3
Cl


CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br
CF3
CF3
Br


CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN
CF3
CF3
CN


CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl
CF3
OCH2CF3
Cl


CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br
CF3
OCH2CF3
Br


CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
CF3
OCH2CF3
CN
















TABLE 29













 










R2 is H,
R2 is H,
R2 is H,
R2 is Me,


R3 is Me
R3 is Et
R3 is i-Pr
R3 is Me














R5
R6
R5
R6
R5
R6
R5
R6










CHF2














Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN







R4 is CH3














Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN







R4 is CF3














Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN







R4 is CH2CF3














Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN


Br
Cl
Br
Cl
Br
Cl
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br


Br
CN
Br
CN
Br
CN
Br
CN


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Br
Cl
Br
Cl
Br
Cl
Br


Cl
CN
Cl
CN
Cl
CN
Cl
CN


CF3
Cl
CF3
Cl
CF3
Cl
CF3
Cl


CF3
Br
CF3
Br
CF3
Br
CF3
Br


CF3
CN
CF3
CN
CF3
CN
CF3
CN


OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl
OCH2CF3
Cl


OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br
OCH2CF3
Br


OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
OCH2CF3
CN
















TABLE 30













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5b is Cl


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is OCF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5 is CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5b is CF(CF3)2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 31













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5b is CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5b is CH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5b is CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5b is CF2CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
















TABLE 32













 










R2 is H, R3 is Me
R2 is H, R3 is Et
R2 is H, R3 is i-Pr
R2 is Me, R3 is Me


















R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6
R4a
R4b
R6










R5b is CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5b is CH2CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5b is CF3


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br







R5b is CF2CHF2


















CH3
H
Cl
CH3
H
Cl
CH3
H
Cl
CH3
H
Cl


CH3
H
Br
CH3
H
Br
CH3
H
Br
CH3
H
Br


CH3
I
Cl
CH3
I
Cl
CH3
I
Cl
CH3
I
Cl


CH3
I
Br
CH3
I
Br
CH3
I
Br
CH3
I
Br


CH3
F
Cl
CH3
F
Cl
CH3
F
Cl
CH3
F
Cl


CH3
F
Br
CH3
F
Br
CH3
F
Br
CH3
F
Br


CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl
CH3
CF3
Cl


CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br
CH3
CF3
Br


CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl
CH3
Br
Cl


CH3
Br
Br
CH3
Br
Br
CH3
Br
Br
CH3
Br
Br


CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl
CH3
Cl
Cl


CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br
CH3
Cl
Br


Cl
H
Cl
Cl
H
Cl
Cl
H
Cl
Cl
H
Cl


Cl
H
Br
Cl
H
Br
Cl
H
Br
Cl
H
Br


Cl
I
Cl
Cl
I
Cl
Cl
I
Cl
Cl
I
Cl


Cl
I
Br
Cl
I
Br
Cl
I
Br
Cl
I
Br


Cl
F
Cl
Cl
F
Cl
Cl
F
Cl
Cl
F
Cl


Cl
F
Br
Cl
F
Br
Cl
F
Br
Cl
F
Br


Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl
Cl
CF3
Cl


Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br
Cl
CF3
Br


Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl


Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br


Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl
Cl


Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br


Br
H
Cl
Br
H
Cl
Br
H
Cl
Br
H
Cl


Br
H
Br
Br
H
Br
Br
H
Br
Br
H
Br


Br
I
Cl
Br
I
Cl
Br
I
Cl
Br
I
Cl


Br
I
Br
Br
I
Br
Br
I
Br
Br
I
Br


Br
F
Cl
Br
F
Cl
Br
F
Cl
Br
F
Cl


Br
F
Br
Br
F
Br
Br
F
Br
Br
F
Br


Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl
Br
CF3
Cl


Br
CF3
Br
Br
CF3
Br
Br
CF3
Br
Br
CF3
Br


Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl


Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br
Br


Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl
Br
Cl
Cl


Br
Cl
Br
Br
Cl
Br
Br
Cl
Br
Br
Cl
Br









Formulation/Utility

Compounds of this invention will generally be used as a formulation or composition with an agriculturally suitable carrier comprising at least one of a liquid diluent, a solid diluent or a surfactant. The formulation or composition ingredients are selected to be consistent with the physical properties of the active ingredient, mode of application and environmental factors such as soil type, moisture and temperature. Useful formulations include liquids such as solutions (including emulsifiable concentrates), suspensions, emulsions (including microemulsions and/or suspoemulsions) and the like which optionally can be thickened into gels. Useful formulations further include solids such as dusts, powders, granules, pellets, tablets, films, and the like which can be water-dispersible (“wettable”) or water-soluble. Active ingredient can be (micro)encapsulated and further formed into a suspension or solid formulation; alternatively the entire formulation of active ingredient can be encapsulated (or “overcoated”). Encapsulation can control or delay release of the active ingredient Sprayable formulations can be extended in suitable media and used at spray volumes from about one to several hundred liters per hectare. High-strength compositions are primarily used as intermediates for further formulation.
The formulations will typically contain effective amounts of active ingredient, diluent and surfactant within the following approximate ranges that add up to 100 percent by weight.













Weight Percent











Active





Ingredient
Diluent
Surfactant














Water-Dispersible
5-90
0-94
1-15


and Water-soluble


Granules, Tablets


and Powders.


Suspensions,
5-50
40-95 
0-15


Emulsions, Solutions


(including


Emulsifiable


Concentrates)


Dusts
1-25
70-99 
0-5 


Granules and
0.01-99  
  5-99.99
0-15


Pellets


High Strength
90-99 
0-10
0-2 


Compositions









Typical solid diluents are described in Watkins, et al., Handbook of Insecticide Dust Diluents and Carriers, 2nd Ed., Dorland Books, Caldwell, N.J. Typical liquid diluents are described in Marsden, Solvents Guide, 2nd Ed., Interscience, New York, 1950. McCutcheon's Detergents and Emulsifiers Annual, Allured Publ. Corp., Ridgewood, N.J., as well as Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foam, caking, corrosion, microbiological growth and the like, or thickeners to increase viscosity.
Surfactants include, for example, polyethoxylated alcohols, polyethoxylated alkylphenols, polyethoxylated sorbitan fatty acid esters, dialkyl sulfosuccinates, alkyl sulfates, alkylbenzene sulfonates, organosilicones, N,N-dialkyltaurates, lignin sulfonates, naphthalene sulfonate formaldehyde condensates, polycarboxylates, and polyoxyethylene/polyoxypropylene block copolymers. Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, starch, sugar, silica, talc, diatomaceous earth, urea, calcium carbonate, sodium carbonate and bicarbonate, and sodium sulfate. Liquid diluents include, for example, water, N,N-dimethylformamide, dimethyl sulfoxide, N-alkylpyrrolidone, ethylene glycol, polypropylene glycol, paraffins, alkylbenzenes, alkylnaphthalenes, oils of olive, castor, linseed, tung, sesame, corn, peanut, cotton-seed, soybean, rape-seed and coconut, fatty acid esters, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy4-methyl-2-pentanone, and alcohols such as methanol, cyclohexanol, decanol and tetrahydrofurfuryl alcohol.
Solutions, including emulsifiable concentrates, can be prepared by simply mixing the ingredients. Dusts and powders can be prepared by blending and, usually, grinding as in a hammer mill or fluid-energy mill. Suspensions are usually prepared by wet-milling; see, for example, U.S. Pat. No. 3,060,084. Granules and pellets can be prepared by spraying the active material upon preformed granular carriers or by agglomeration techniques. See Browning, “Agglomeration”, Chemical Engineering, Dec. 4, 1967, pp 147-48, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963, pages 8-57 and following, and PCT Publication WO 91/13546. Pellets can be prepared as described in U.S. Pat. No. 4,172,714. Water-dispersible and water-soluble granules can be prepared as taught in U.S. Pat. No. 4,144,050, U.S. Pat. No. 3,920,442 and DE 3,246,493. Tablets can be prepared as taught in U.S. Pat. Nos. 5,180,587, 5,232,701 and 5,208,030. Films can be prepared as taught in GB 2,095,558 and U.S. Pat. No. 3,299,566.
For further information regarding the art of formulation, see T. S. Woods, “The Formulator's Toolbox—Product Forms for Modem Agriculture” in Pesticide Chemistry and Bioscience, The Food-Environment Challenge, T. Brooks and T. R. Roberts, Eds., Proceedings of the 9th International Congress on Pesticide Chemistry, The Royal Society of Chemistry, Cambridge, 1999, pp. 120-133. See also U.S. Pat. No. 3,235,361, Col. 6, line 16 through Col. 7, line 19 and Examples 10-41; U.S. Pat. No. 3,309,192, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; U.S. Pat. No. 2,891,855, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, 1961, pp 81-96; and Hance et al., Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989.
In the following Examples, all percentages are by weight and all formulations are prepared in conventional ways. Compound numbers refer to compounds in Index Table A.
EXAMPLE A
Wettable Powder
















Compound 1
65.0% 



dodecylphenol polyethylene glycol ether
2.0%



sodium ligninsulfonate
4.0%



sodium silicoaluminate
6.0%



montmorillonite (calcined)
 23.0%. 










EXAMPLE B
Granule
















Compound 1
10.0%



attapulgite granules (low volatile matter,
90.0%.



0.71/0.30 mm; U.S.S. No. 25-50 sieves)










EXAMPLE C
Extruded Pellet
















Compound 1
25.0%



anhydrous sodium sulfate
10.0%



crude calcium ligninsulfonate
 5.0%



sodium alkylnaphthalenesulfonate
 1.0%



calcium/magnesium bentonite
 59.0%.










EXAMPLE D
Emulsifiable Concentrate
















Compound 1
20.0%



blend of oil soluble sulfonates
10.0%



and polyoxyethylene ethers



isophorone
70.0%.










EXAMPLE E
Granule
















Compound 1
0.5%



cellulose
2.5%



lactose
4.0%



cornmeal
 93.0%. 










Compounds of this invention are characterized by favorable metabolic and/or soil residual patterns and exhibit activity controlling a spectrum of agronomic and non-agronomic invertebrate pests. (In the context of this disclosure “invertebrate pest control” means inhibition of invertebrate pest development (including mortality) that causes significant reduction in feeding or other injury or damage caused by the pest; related expressions are defined analogously.) As referred to in this disclosure, the term “invertebrate pest” includes arthropods, gastropods and nematodes of economic importance as pests. The term “arthropod” includes insects, mites, spiders, scorpions, centipedes, millipedes, pill bugs and symphylans. The term “gastropod” includes snails, slugs and other Stylommatophora. The term “nematode” includes all of the helminths, such as: roundworms, heartworms, and phytophagous nematodes (Nematoda), flukes (Tematoda), Acanthocephala, and tapeworms (Cestoda). Those skilled in the art will recognize that not all compounds are equally effective against all pests. Compounds of this invention display activity against economically important agronomic and nonagronomic pests. The term “agronomic” refers to the production of field crops such as for food and fiber and includes the growth of cereal crops (e.g., wheat, oats, barley, rye, rice, maize), soybeans, vegetable crops (e.g., lettuce, cabbage, tomatoes, beans), potatoes, sweet potatoes, grapes, cotton, and tree fruits (e.g., pome fruits, stone fruits and citrus fruits). The term “nonagronomic” refers to other horticultural (e.g., forest, greenhouse, nursery or ornamental plants not grown in a field), public (human) and animal health, domestic and commercial structure, household, and stored product applications or pests. For reason of invertebrate pest control spectrum and economic importance, protection (from damage or injury caused by invertebrate pests) of agronomic crops of cotton, maize, soybeans, rice, vegetable crops, potato, sweet potato, grapes and tree fruit by controlling invertebrate pests are preferred embodiments of the invention. Agronomic or nonagronomic pests include larvae of the order Lepidoptera, such as armyworms, cutworms, loopers, and heliothines in the family Noctuidae (e.g., fall armywormn (Spodoptera fugiperda J. E. Smith), beet armyworm (Spodoptera exigua Hübner), black cutworm (Agrotis epsilon Hufnagel), cabbage looper (Trichoplusia ni Hübner), tobacco budworm (Heliothis virescens Fabricius)); borers, casebearers, webworms, coneworms, cabbageworms and skeletonizers from the family Pyralidae (e.g., European corn borer (Ostrinia nubilalis Hübner), navel orangeworm (Amyelois transitella Walker), corn root webworm (Crambus caliginosellus Clemens), sod webworm (Herpetogramma licarsisalis Walker)); leafrollers, budworms, seed worms, and fruit worms in the family Tortricidae (e.g., codling moth (Cydia pomonella Linnaeus), grape berry moth (Endopiza viteana Clemens), oriental fruit moth (Grapholita molesta Busck)); and many other economically important lepidoptera (e.g., diamondback moth (Plutella xylostella Linnaeus), pink bollworm (Pectinophora gossypiella Saunders), gypsy moth (Lymantria dispar Linnaeus)); nymphs and adults of the order Blattodea including cockroaches from the families Blattellidae and Blattidae (e.g., oriental cockroach (Blatta orientalis Linnaeus), Asian cockroach (Blatella asahinai Mizukubo), German cockroach (Blattella germanica Linnaeus), brownbanded cockroach (Supella longipalpa Fabricius), American cockroach (Periplaneta americana Linnaeus), brown cockroach (Periplaneta brunnea Burmeister), Madeira cockroach (Leucophaea maderae Fabricius)); foliar feeding larvae and adults of the order Coleoptera including weevils from the families Anthribidae, Bruchidae, and Curculionidae (e.g., boll weevil (Anthonomus grandis Boheman), rice water weevil (Lissorhoptrus oryzophilus Kuschel), granary weevil (Sitophilus granarius Linnaeus), rice weevil (Sitophilus oryzae Linnaeus)); flea beetles, cucumber beetles, rootworms, leaf beetles, potato beetles, and leafminers in the family Chrysomelidae (e.g., Colorado potato beetle (Leptinotarsa decemlineata Say), western corn rootworm (Diabrotica virgifera virgifera LeConte)); chafers and other beetles from the family Scaribaeidae (e.g., Japanese beetle (Popillia japonica Newman) and European chafer (Rhizotrogus majalis Razoumowsky)); carpet beetles from the family Dermestidae; wireworms from the family Elateridae; bark beetles from the family Scolytidae and flour beetles from the family Tenebrionidae. In addition agronomic and nonagronomic pests include: adults and larvae of the order Dermaptera including earwigs from the family Forficulidae (e.g., European earwig (Forficula auricularia Linnaeus), black earwig (Chelisoches morio Fabricius)); adults and nymphs of the orders Hemiptera and Homoptera such as, plant bugs from the family Miridae, cicadas from the family Cicadidae, leafhoppers (e.g. Empoasca spp.) from the family Cicadellidae, planthoppers from the families Fulgoroidae and Delphacidae, treehoppers from the family Membracidae, psyllids from the family Psyllidae, whiteflies from the family Aleyrodidae, aphids from the family Aphididae, phylloxera from the family Phylloxeridae, mealybugs from the family Pseudococcidae, scales from the families Coccidae, Diaspididae and Margarodidae, lace bugs from the family Tingidae, stink bugs from the family Pentatomidae, cinch bugs (e.g., Blissus spp.) and other seed bugs from the family Lygaeidae, spittlebugs from the family Cercopidae squash bugs from the family Coreidae, and red bugs and cotton stainers from the family Pyrrhocoridae. Also included are adults and larvae of the order Acari (mites) such as spider mites and red mites in the family Tetranychidae (e.g., European red mite (Panonychus ulmi Koch), two spotted spider mite (Tetranychus urticae Koch), McDaniel mite (Tetranychus mcdanieli McGregor)), flat mites in the family Tenuipalpidae (e.g., citrus flat mite (Brevipalpus lewisi McGregor)), rust and bud mites in the family Eriophyidae and other foliar feeding mites and mites important in human and animal health, i.e. dust mites in the family Epidermoptidae, follicle mites in the family Demodicidae, grain mites in the family Glycyphagidae, ticks in the order Ixodidae (e.g., deer tick (Ixodes scapularis Say), Australian paralysis tick (Ixodes holocyclus Neumann), American dog tick (Dermacentor variabilis Say), lone star tick (Amblyomma americanum Linnaeus) and scab and itch mites in the families Psoroptidae, Pyemotidae, and Sarcoptidae; adults and immatures of the order Orthoptera including grasshoppers, locusts and crickets (e.g., migratory grasshoppers (e.g., Melanoplus sanguinipes Fabricius, M. differentialis Thomas), American grasshoppers (e.g., Schistocerca americana Drury), desert locust (Schistocerca gregaria Forskal), migratory locust (Locusta migratoria Linnaeus), house cricket (Acheta domesticus Linnaeus), mole crickets (Gryllotalpa spp.)); adults and immatures of the order Diptera including leafminers, midges, fruit flies (Tephritidae), frit flies (e.g., Oscinella frit Linnaeus), soil maggots, house flies (e.g., Musca domestica Linnaeus), lesser house flies (e.g., Fannia canicularis Linnaeus, F. femoralis Stein), stable flies (e.g., Stomoxys calcitrans Linnaeus), face flies, horn flies, blow flies (e.g., Chrysomya spp., Phormia spp.), and other muscoid fly pests, horse flies (e.g., Tabanus spp.), bot flies (e.g., Gastrophilus spp., Oestrus spp.), cattle grubs (e.g., Hypoderma spp.), deer flies (e.g., Chrysops spp.), keds (e.g., Melophagus ovinus Linnaeus) and other Brachycera, mosquitoes (e.g., Aedes spp., Anopheles spp., Culex spp.), black flies (e.g., Prosimulium spp., Simulium spp.), biting midges, sand flies, sciarids, and other Nematocera; adults and immatures of the order Thysanoptera including onion thrips (Thrips tabaci Lindeman) and other foliar feeding thrips; insect pests of the order Hymenoptera including ants (e.g., red carpenter ant (Camponotus ferrugineus Fabricius), black carpenter ant (Camponotus pennsylvanicus De Geer), Pharaoh ant (Monomorium pharaonis Linnaeus), little fire ant (Wasmannia auropunctata Roger), fire ant (Solenopsis geminata Fabricius), red imported fire ant (Solenopsis invicta Buren), Argentine ant (Iridomyrmex humilis Mayr), crazy ant (Paratrechina longicornis Latreille), pavement ant (Tetramorium caespitum Linnaeus), cornfield ant (Lasius alienus Förster), odorous house ant (Tapinoma sessile Say)), bees (including carpenter bees), hornets, yellow jackets and wasps; insect pests of the order Isoptera including the eastern subterranean termite (Reticulitermes flavipes Kollar), western subterranean termite (Reticulitermes hesperus Banks), Formosan subterranean termite (Coptotermes formosanus Shiraki), West Indian drywood termite (Incisitermes immigrans Snyder) and other termites of economic importance; insect pests of the order Thysanura such as silverfish (Lepisma saccharina Linnaeus) and firebrat (Thermobia domestica Packard); insect pests of the order Mallophaga and including the head louse (Pediculus humanus capitis De Geer), body louse (Pediculus humanus humanus Linnaeus), chicken body louse (Menacanthus stramineus Nitszch), dog biting louse (Trichodectes canis De Geer), fluff louse (Goniocotes gallinae De Geer), sheep body louse (Bovicola ovis Schrank), short-nosed cattle louse (Haematopinus eurysternus Nitzsch), long-nosed cattle louse (Linognathus vituli Linnaeus) and other sucking and chewing parasitic lice that attack man and animals; insect pests of the order Siphonoptera including the oriental rat flea (Xenopsylla cheopis Rothschild), cat flea (Ctenocephalides felis Bouche), dog flea (Ctenocephalides canis Curtis), hen flea (Ceratophyllus gallinae Schrank), sticktight flea (Echidnophaga gallinacea Westwood), human flea (Pulex irritans Linnaeus) and other fleas afflicting mammals and birds. Additional arthropod pests covered include: spiders in the order Araneae such as the brown recluse spider (Loxosceles reclusa Gertsch & Mulaik) and the black widow spider (Latrodectus mactans Fabricius), and centipedes in the order Scutigeromorpha such as the house centipede (Scutigera coleoptrata Linnaeus). Compounds of the present invention also have activity on members of the Classes Nematoda, Cestoda, Trematoda, and Acanthocephala including economically important members of the orders Strongylida, Ascaridida, Oxyurida, Rhabditida, Spirurida, and Enoplida such as but not limited to economically important agricultural pests (i.e. root knot nematodes in the genus Meloidogyne, lesion nematodes in the genus Pratylenchus, stubby root nematodes in the genus Trichodorus, etc.) and animal and human health pests (i.e. all economically important flukes, tapeworms, and roundworms, such as Strongylus vulgaris in horses, Toxocara canis in dogs, Haemonchus contortus in sheep, Dirofilaria immitis Leidy in dogs, Anoplocephala perfoliata in horses, Fasciola hepatica Linnaeus in ruminants, etc.).
Compounds of the invention show particularly high activity against pests in the order Lepidoptera (e.g., Alabama argillacea Hübner (cotton leaf worm), Archips argyrospila Walker (fruit tree leaf roller), A. rosana Linnaeus (European leaf roller) and other Archips species, Chilo suppressalis Walker (rice stem borer), Cnaphalocrosis medinalis Guenee (rice leaf roller), Crambus caliginosellus Clemens (corn root webworm), Crambus teterrellus Zincken (bluegrass webworm), Cydia pomonella Linnaeus (codling moth), Earias insulana Boisduval (spiny bollworm), Earias vittella Fabricius (spotted bollworm), Helicoverpa armigera Hübner (American bollworm), Helicoverpa zea Boddie (corn earworm), Heliothis virescens Fabricius (tobacco budworm), Herpetogramma licarsisalis Walker (sod webworm), Lobesia botrana Denis & Schiffermüller (grape berry moth), Pectinophora gossypiella Saunders (pink bollworm), Phyllocnistis citrella Stainton (citrus leafminer), Pieris brassicae Linnaeus (large white butterfly), Pieris rapae Linnaeus (small white butterfly), Plutella xylostella Linnaeus (diamondback moth), Spodoptera exigua Hübner (beet armyworm), Spodoptera litura Fabricius (tobacco cutworm, cluster caterpillar), Spodoptera frugiperda J. E. Smith (fall armyworm), Trichoplusia ni Hübner (cabbage looper) and Tuta absoluta Meyrick (tomato leafminer)). Compounds of the invention also have commercially significant activity on members from the order Homoptera including: Acyrthisiphon pisum Harris (pea aphid), Aphis craccivora Koch (cowpea aphid), Aphis fabae Scopoli (black bean aphid), Aphis gossypii Glover (cotton aphid, melon aphid), Aphis pomi De Geer (apple aphid), Aphis spiraecola Patch (spirea aphid), Aulacorthum solani Kaltenbach (foxglove aphid), Chaetosiphon fragaefolii Cockerell (strawberry aphid), Diuraphis noxia Kurdjumov/Mordvilko (Russian wheat aphid), Dysaphis plantaginea Paaserini (rosy apple aphid), Eriosoma lanigerum Hausmann (woolly apple aphid), Hyalopterus pruni Geoffroy (mealy plum aphid), Lipaphis erysimi Kaltenbach (turnip aphid), Metopolophium dirrhodum Walker (cereal aphid), Macrosipum euphorbiae Thomas (potato aphid), Myzus persicae Sulzer (peach-potato aphid, green peach aphid), Nasonovia ribisnigri Mosley (lettuce aphid), Pemphigus spp. (root aphids and gall aphids), Rhopalosiphum maidis Fitch (corn leaf aphid), Rhopalosiphum padi Linnaeus (bird cherry-oat aphid), Schizaphis graminum Rondani (greenbug), Sitobion avenae Fabricius (English grain aphid), Therioaphis maculata Buckton (spotted alfalfa aphid), Toxoptera aurantii Boyer de Fonscolombe (black citrus aphid), and Toxoptera citricida Kirkaldy (brown citrus aphid); Adelges spp. (adelgids); Phylloxera devastatrix Pergande (pecan phylloxera); Bemisia tabaci Gennadius (tobacco whitefly, sweetpotato whitefly), Bemisia argentifolii Bellows & Perring (silverleaf whitefly), Dialeurodes citri Ashmead (citrus whitefly) and Trialeurodes vaporariorum Westwood (greenhouse whitefly); Empoasca fabae Harris (potato leafhopper), Laodelphax striatellus Fallen (smaller brown planthopper), Macrolestes quadrilineatus Forbes (aster leafhopper), Nephotettix cinticeps Uhler (green leafhopper), Nephotettix nigropictus St{dot over (a)}l (rice leafhopper), Nilaparvata lugens St{dot over (a)}l (brown planthopper), Peregrinus maidis Ashmead (corn planthopper), Sogatella furcifera Horvath white-backed planthopper), Sogatodes orizicola Muir (rice delphacid), Typhlocyba pomaria McAtee white apple leafhopper, Erythroneoura spp. (grape leafhoppers); Magicidada septendecim Linnaeus (periodical cicada); Icerya purchasi Maskell (cottony cushion scale), Quadraspidiotus perniciosus Comstock (San Jose scale); Planococcus citri Risso (citrus mealybug); Pseudococcus spp. (other mealybug complex); Cacopsylla pyricola Foerster (pear psylla), Trioza diospyri Ashmead (persimrnon psylla). These compounds also have activity on members from the order Hemiptera including: Acrosternum hilare Say (green stink bug), Anasa tristis De Geer (squash bug), Blissus leucopterus leucopterus Say (chinch bug), Corythuca gossypii Fabricius (cotton lace bug), Cyrtopeltis modesta Distant (tomato bug), Dysdercus suturellus Herrich-Schäffer (cotton stainer), Euchistus servus Say (brown stink bug), Euchistus variolarius Palisot de Beauvois (one-spotted stink bug), Graptosthetus spp. (complex of seed bugs), Leptoglossus corculus Say (leaf-footed pine seed bug), Lygus lineolaris Palisot de Beauvois (tarnished plant bug), Nezara viridula Linnaeus (southern green stink bug), Oebalus pugna Fabricius (rice stink bug), Oncopeltus fasciatus Dallas (large milkweed bug), Pseudatomoscelis seriatus Reuter (cotton fleahopper). Other insect orders controlled by compounds of the invention include Thysanoptera (e.g., Frankliniella occidentalis Pergande (western flower thrip), Scirthothrips citri Moulton (citrus thrip), Sericothrips variabilis Beach (soybean thrip), and Thrips tabaci Lindeman (onion thrip); and the order Coleoptera (e.g., Leptinotarsa decemlineata Say (Colorado potato beetle), Epilachna varivestis Mulsant (Mexican bean beetle) and wireworms of the genera Agriotes, Athous or Limonius). 
Compounds of this invention can also be mixed with one or more other biologically active compounds or agents including insecticides, fungicides, nematocides, bactericides, acaricides, growth regulators such as rooting stimulants, chemosterilants, semiochemicals, repellents, attractants, pheromones, feeding stimulants, other biologically active compounds or entomopathogenic bacteria, virus or fungi to form a multi-component pesticide giving an even broader spectrum of agricultural utility. Thus compositions of the present invention can further comprise a biologically effective amount of at least one additional biologically active compound or agent. Examples of such biologically active compounds or agents with which compounds of this invention can be formulated are: insecticides such as abamectin, acephate, acetamiprid, avermectin, azadirachtin, azinphos-methyl, bifenthrin, binfenazate, buprofezin, carbofuran, chlorfenapyr, chlorfluazuron, chlorpyrifos, chlorpyrifos-methyl, chromafenozide, clothianidin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, cypermethrin, cyromazine, deltamethrin, diafenthiuron, diazinon, diflubenzuron, dimethoate, diofenolan, emamectin, endosulfan, esfenvalerate, ethiprole, fenothicarb, fenoxycarb, fenpropathrin, fenproximate, fenvalerate, fipronil, flonicamid, flucythrinate, tau-fluvalinate, flufenoxuron, fonophos, halofenozide, hexaflurnuron, imidacloprid, indoxacarb, isofenphos, lufenuron, malathion, metaldehyde, methamidophos, methidathion, methomyl, methoprene, methoxychlor, monocrotophos, methoxyfenozide, nithiazin, novaluron, oxamyl, parathion, parathion-methyl, permethrin, phorate, phosalone, phosmet, phosphamidon, pirimicarb, profenofos, pymetrozine, pyridalyl, pyriproxyfen, rotenone, spinosad, sulprofos, tebufenozide, teflubenzuron, tefluthrin, terbufos, tetrachlorvinphos, thiacloprid, thiamethoxam, thiodicarb, thiosultap-sodium, tralomethrin, trichlorfon and triflumuron; fungicides such as acibenzolar, azoxystrobin, benomyl, blasticidin-S, Bordeaux mixture (tribasic copper sulfate), bromuconazole, carpropamid, captafol, captan, carbendazirn, chloroneb, chlorothalonil, copper oxychloride, copper salts, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, (S)-3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide (RH 7281), diclocymet (S-2900), diclomezine, dicloran, difenoconazole, (S)-3,5-dihydro-5-methyl-2-(methylthio)-5-phenyl-3-(phenylamino)4H-imidazol-4one (RP 407213), dimethomorph, dimoxystrobin, diniconazole, diniconazole-M, dodine, edifenphos, epoxiconazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fencaramid (SZX0722), fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fentin hydroxide, fluazinam, fludioxonil, flumetover (RPA 403397), fluquinconazole, flusilazole, flutolanil, flutriafol, folpet, fosetyl-aluminum, furalaxyl, furarnetapyr (S-82658), hexaconazole, ipconazole, iprobenfos, iprodione, isoprothiolane, kasugamycin, kresoxim-methyl, mancozeb, maneb, mefenoxam, mepronil, metalaxyl, metconazole, metomino-strobin/fenominostrobin (SSF-126), myclobutanil, neo-asozin (ferric methanearsonate), oxadixyl, penconazole, pencycuron, probenazole, prochloraz, propamocarb, propiconazole, pyrifenox, pyraclostrobin, pyrimethanil, pyroquilon, quinoxyfen, spiroxamine, sulfur, tebuconazole, tetraconazole, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tiadinil, triadimefon, triadimenol, tricyclazole, trifloxystrobin, triticonazole, validamycin and vinclozolin; nematocides such as aldicarb, oxamyl and fenamiphos; bactericides such as streptomycin; acaricides such as amitraz, chinomethionat, chlorobenzilate, cyhexatin, dicofol, dienochlor, etoxazole, fenazaquin, fenbutatin oxide, fenpropathrin, fenpyroximate, hexythiazox, propargite, pyridaben and tebufenpyrad; and biological agents such as Bacillus thuringiensis including ssp. aizawai and kurstaki, Bacillus thuringiensis delta endotoxin, baculovirus, and entomopathogenic bacteria, virus and fungi. Compounds of this invention and compositions thereof may be applied to plants genetically transformed to express proteins toxic to invertebrate pests (such as Bacillus thuringiensis toxin). The effect of the exogenous invertebrate pest control compounds and compositions may be synergistic with the expressed toxin proteins.
A general reference for these agricultural protectants is The Pesticide Manual, 12th Edition, C. D. S. Tomlin, Ed., British Crop Protection Council, Farnham, Surrey, U.K., 2000.
Preferred insecticides and acaricides for mixing with compounds of this invention include pyrethroids such as cypermethrin, cyhalotlrin, cyfluthrin, beta-cyfluthrin, esfenvalerate, fenvalerate and tralomethrin; carbamates such as fenothicarb, methomyl, oxamyl and thiodicarb; neonicotinoids such as clothianidin, imidacloprid and thiacloprid; neuronal sodium channel blockers such as indoxacarb; insecticidal macrocyclic lactones such as spinosad, abamectin, avermectin and emamectin; γ-aminobutyric acid (GABA) antagonists such as endosulfan, ethiprole and fipronil; insecticidal ureas such as flufenoxuron and triflumuron; juvenile hormone mimics such as diofenolan and pyriproxyfen; pymetrozine; and amitraz. Preferred biological agents for mixing with compounds of this invention include Bacillus thuringiensis and Bacillus thuringiensis delta endotoxin as well as naturally occurring and genetically modified viral insecticides including members of the family Baculoviridae as well as entomophagous fungi.
Most preferred mixtures include a mixture of a compound of this invention with cyhalothrin; a mixture of a compound of this invention with beta-cyfluthrin; a mixture of a compound of this invention with esfenvalerate; a mixture of a compound of this invention with methomyl; a mixture of a compound of this invention with imidacloprid; a mixture of a compound of this invention with thiacloprid; a mixture of a compound of this invention with indoxacarb; a mixture of a compound of this invention with abamectin; a mixture of a compound of this invention with endosulfan; a mixture of a compound of this invention with ethiprole; a mixture of a compound of this invention with fipronil; a mixture of a compound of this invention with flufenoxuron; a mixture of a compound of this invention with pyriproxyfen; a mixture of a compound of this invention with pymetrozine; a mixture of a compound of this invention with amitraz; a mixture of a compound of this invention with Bacillus thuringiensis and a mixture of a compound of this invention with Bacillus thuringiensis delta endotoxin.
In certain instances, combinations with other invertebrate pest control compounds or agents having a similar spectrum of control but a different mode of action will be particularly advantageous for resistance management. Thus, compositions of the present invention can further comprise a biologically effective amount of at least one additional invertebrate pest control compound or agent having a similar spectrum of control but a different mode of action. Contacting a plant genetically modified to express a plant protection compound (e.g., protein) or the locus of the plant with a biologically effective amount of a compound of invention can also provide a broader spectrum of plant protection and be advantageous for resistance management.
Invertebrate pests are controlled in agronomic and nonagronomic applications by applying one or more of the compounds of this invention, in an effective amount, to the environment of the pests including the agronomic and/or nonagronomic locus of infestation, to the area to be protected, or directly on the pests to be controlled. Thus, the present invention further comprises a method for the control of invertebrates in agronomic and/or nonagronomic applications, comprising contacting the invertebrates or their environment with a biologically effective amount of one or more of the compounds of the invention, or with a composition comprising at least one such compound or a composition comprising at least one such compound and an effective amount of at least one additional biologically active compound or agent. Examples of suitable compositions comprising a compound of the invention and an effective amount of at least one additional biologically active compound or agent include granular compositions wherein the additional biologically active compound is present on the same granule as the compound of the invention or on granules separate from those of the compound of this invention.
A preferred method of contact is by spraying. Alternatively, a granular composition comprising a compound of the invention can be applied to the plant foliage or the soil. Compounds of this invention are also effectively delivered through plant uptake by contacting the plant with a composition comprising a compound of this invention applied as a soil drench of a liquid formulation, a granular formulation to the soil, a nursery box treatment or a dip of transplants. Compounds are also effective by topical application of a composition comprising a compound of this invention to the locus of infestation. Other methods of contact include application of a compound or a composition of the invention by direct and residual sprays, aerial sprays, gels, seed coatings, microencapsulations, systemic uptake, baits, eartags, boluses, foggers, fumigants, aerosols, dusts and many others. The compounds of this invention may also be impregnated into materials for fabricating invertebrate control devices (e.g. insect netting).
The compounds of this invention can be incorporated into baits that are consumed by the invertebrates or within devices such as traps and the like. Granules or baits comprising between 0.01-5% active ingredient, 0.05-10% moisture retaining agent(s) and 40-99% vegetable flour are effective in controlling soil insects at very low application rates, particularly at doses of active ingredient that are lethal by ingestion rather than by direct contact.
The compounds of this invention can be applied in their pure state, but most often application will be of a formulation comprising one or more compounds with suitable carriers, diluents, and surfactants and possibly in combination with a food depending on the contemplated end use. A preferred method of application involves spraying a water dispersion or refined oil solution of the compounds. Combinations with spray oils, spray oil concentrations, spreader stickers, adjuvants, other solvents, and synergists such as piperonyl butoxide often enhance compound efficacy.
The rate of application required for effective control (i.e. “biologically effective amount”) will depend on such factors as the species of invertebrate to be controlled, the pest's life cycle, life stage, its size, location, time of year, host crop or animal, feeding behavior, mating behavior, ambient moisture, temperature, and the like. Under normal circumstances, application rates of about 0.01 to 2 kg of active ingredient per hectare are sufficient to control pests in agronomic ecosystems, but as little as 0.0001 kg/hectare may be sufficient or as much as 8 kg/hectare may be required. For nonagronomic applications, effective use rates will range from about 1.0 to 50 mg/square meter but as little as 0.1 mg/square meter may be sufficient or as much as 150 mg/square meter may be required. One skilled in the art can easily determine the biologically effective amount necessary for the desired level of invertebrate pest control.
The following TESTS demonstrates the control efficacy of compounds of this invention on specific pests. “Control efficacy” represents inhibition of invertebrate pest development (including mortality) that causes significantly reduced feeding. The pest control protection afforded by the compounds is not limited, however, to these species. See Index Tables A through K and L for compound descriptions. The following abbreviations are used in the Index Tables which follow: t is tertiary, n is normal, i is iso, c is cyclo, s is secondary, Me is methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, c-Pr is cyclopropyl, Bu is butyl, s-Bu is secondary butyl, Pent is pentyl, OMe is methoxy, OEt is ethoxy, SMe is methylthio, SEt is ethylthio, CN is cyano, and NO2 is nitro. The abbreviation “Ex.” stands for “Example” and is followed by a number indicating in which example the compound is prepared.







INDEX TABLE A













 












Compound
R2
R3
(R4)n
J
m.p. ° C.





1 (Ex. 3)
H
i-Pr
4-Me
4-CF3—Ph
*


2
H
t-Bu
4-Me
4-CF3—Ph
*


3
H
i-Pr
4-Me
4-OCF3—Ph
*


4
H
i-Pr
4-Me
2-Me,SCHF2—Ph


5
H
t-Bu
4-Me
2-Me,SCHF2—Ph
*


6
H
t-Bu
4-Me
4-OCF3—Ph


7
H
i-Pr
4-Me
2-Me,4-SO2CHF2—Ph
*


8
H
i-Pr
4-Me
2-Me,4-SOCF3—Ph
*


9
H
t-Bu
4-Me
2-Me,4-SO2CHF2—Ph


10
H
t-Bu
4-Me
2-Me,4-SOCHF2—Ph
*


11
H
i-Pr
4-Me
SCHF2—Ph
*


12
H
t-Bu
4-Me
SCHF2—Ph


13
H
i-Pr
4-Me
2-Me,4-CF3—Ph
*


14
H
i-Pr
4-Me
2-Me,4-OCF3—Ph


15
H
t-Bu
4-Me
2-Me,4-CF3—Ph
*


16
H
t-Bu
4-Me
2-Me,4-OCF3—Ph
*


17
H
i-Pr
4-Me
2-Me,4-Cl—Ph
222.5-225


18
H
t-Bu
4-Me
2-Me,4-Cl—Ph
214-215


19
H
i-Pr
4-Me
2-Me—6-CF3-3-pyridinyl


20
H
t-Bu
4-Me
2-Me—6-CF3-3-pyridinyl


21
H
i-Pr
4-Me
1-Ph—3-Me-5-pyrazolyl


22
H
t-Bu
4-Me
1-Ph—3-Me-5-pyrazolyl


23
H
i-Pr
4-Me
2-Me—6-Cl-3-pyridinyl


24
H
t-Bu
4-Me
2-Me—6-Cl-3-pyridinyl


25
H
CH2CH2NMe2
4,5-Me2
Ph


26
—CH2CH2CH2CH2—
H
Ph


27
H
c-hexyl
H
Ph


28
H
c-propyl
H
Ph


29
H
H
4-t-Bu—Ph
3,5-Cl2—Ph


35
H
Me
4-Me
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
201-203


36
H
Me
4,5-Cl2
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
238-240


37
H
i-Pr
4,5-Cl2
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
240


40
H
i-Pr
4-Me—5-Cl
1-(2-Cl-3-pyridinyl)-3-CF3-5-pyrazolyl
234-236


*See Index Table L for 1H NMR data.













INDEX TABLE B













 










Com-





pound
R3
J
m.p. ° C.





B1
i-Pr
2-Me,SCHF2—Ph
178.5-180.5


B2
i-Pr
2-Me,4-SO2CHF2—Ph
207-210


B4
i-Pr
2-Me,4-CF3—Ph
201-203


B5
i-Pr
2-Me-6-CF3-3-pyridinyl
221-5-222.5


B6
i-Pr
1-Ph-3-Me-5-pyrazolyl


B7
t-Bu
1-Ph-3-Me-5-pyrazolyl


B8
t-Bu
2-Me-6-CF3-3-pyridinyl


B9
i-Pr
2-Me-5-Cl-3-thienyl


B10
Me
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
266-270


B11
i-Pr
1-(2-Cl-Ph)—3-CF3-5-pyrazolyl
232-236


*See Index Table L for 1H NMR data.













INDEX TABLE C













 












Compound
R2
R3
R4
J
m.p. ° C.





C1
H
i-Pr
Me
4-F—Ph
*


C2
H
i-Pr
Me
4-Br—Ph
*


C3
H
i-Pr
Me
4-Cl—Ph
*


C4
H
i-Pr
Me
2-NO2—Ph


C5
H
i-Pr
Me
3-Cl—Ph
*


C6
H
i-Pr
Me
4-CN—Ph


C7
H
i-Pr
Me
4-CF3—Ph


C8
H
i-Pr
Me
2-Me—4-SOCF3—Ph
*


C9 Ex. 2)
H
i-Pr
Me
4-OCF3—Ph
68-75


C10
H
i-Pr
Me
2-Me—4-Br—Ph
*


C11
Pr
Pr
Ph
3-F—Ph


C12
—(CH2)5—

Ph
2-thienyl


C13
—(CH2)2NMe(CH2)2—

Ph
4-NO2—Ph


C14
H
i-Pr
Me
3-pyridinyl


C15
H
c-hexyl
Ph
2-thienyl


C16
allyl
ally
Ph
2-Me—Ph


C17
Et
Et
Ph
Ph


C18
H
ally
Ph
Ph


C19
H
(CH2)2Ph
Ph
Ph


C20
Me
Me
Ph
4-Me—Ph


C21
—(CH2)2NMe(CH2)2—

Ph
4-Br—Ph


C22
—(CH2)2O(CH2)2—

Ph
Ph


C27
H
i-Pr
Me
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
218-220


C28
H
i-Pr
Me
1-(2-Cl-Ph)-3-Br-5-pyrazolyl
170-173


C29
H
CH2-2-furanyl
Ph
3-Me—Ph


C42

—(CH2)6—
Ph
4-Br—Ph


C43

—(CH2)4—
Ph
4-Me—Ph


C44

—(CH2)5—
Ph
3-F—Ph


C45

—(CH2)4—
Ph
3-F—Ph


C46
H
CH2Ph
Ph
2-F—Ph


C47
H
CH2-2-furanyl
Ph
3-F—Ph


C48

—(CH2)6—
Ph
4-Me—Ph


C49
—(CH2)2O(CH2)2—

Ph
2-Me—Ph





*See Index Table L for 1NMR data.













INDEX TABLE D













 












Com-







pound
R2
R3
R4
J
m.p. ° C.





D1 
H
i-Pr
2-Me
4-CF3-Ph
223-225


D2 
H
t-Bu
2-Me
4-CF3-Ph
260-261


D3 (Ex. 1)
H
i-Pr
2-Me
4-OCF3-Ph
202-204


D4 
H
i-Pr
2-Me
2-Me,4-CF3-Ph
235-236


D5 
H
i-Pr
2-Me
2-Me,4-OCF3-Ph
198-200


D6 
H
i-Pr
2-Me
2-Me-6-CF3-3-pyridinyl
240-243


D7 
H
i-Pr
2-Me
1-Ph-3-CF3-5-pyrazolyl
215-220







(dec.)


D8 
H
i-Pr
2-Me
1-(2-Cl-Ph)-3-CF3-5-
140-144






pyrazolyl


D9 
H
i-Pr
2-Me
2-Me-3-Cl-Ph
260-261


D11
Me
Me
2-Me
1-(2-Cl-Ph)-3-CF3-5-
172-175






pyrazolyl


D12
H
Me
2-Me
1-(2-Cl-Ph)-3-CF3-5-
193-195






pyrazolyl













INDEX TABLE E













 












Compound
R2
R3
(R4)n
J
m.p. ° C.





E1 
H
i-Pr
H
4-CF3-Ph
*


E2 
H
i-Pr
H
4-OCF3-Ph
*


E3 
H
i-Pr
2-Cl
4-CF3-Ph
*


E4 
H
i-Pr
H
2-Me,3-Cl-Ph
*


E5 
H
i-Pr
2-Me
1-(2-Cl-3-pyridinyl)-3-CF3-5-pyrazolyl
138-140


E6 
H
i-Pr
2-Me
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
170-173


E7 
H
i-Pr
2-Me
1-(2-Cl-Ph)-3-Br-5-pyrazolyl
*


E15 (Ex. 5)
H
i-Pr
2,6-Cl2
1-(2-Cl-3-pyridinyl)-3-CF3-5-pyrazolyl
240-242


E18
Me
Me
2,6-Br2
2,6-Br2-3-NH2-4-pyridinyl
208-210


E27
H
Me
2,6-Br2
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
*


E28
H
Et
2,6-Br2
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
*


E34
H
i-Pr
2,6-Br2
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
*


E35
H
NMe2
2,6-Cl2
2,6-Cl2-3-NH2-4-pyridinyl
*


E36
Et
Et
2,6-Cl2
2,6-Cl2-3-NH2-4-pyridinyl
*





*See Index Table L for 1H NMR data.













INDEX TABLE F













 











Compound
R3
(R4)n
J
m.p. ° C.





F1
i-Pr
H
4-CF3-Ph
*


F2
t-Bu
H
4-CF3-Ph
199-200


F3
i-Pr
6-Me
4-CF3-Ph
218-220


F4
i-Pr
4,6-Me2
4-CF3-Ph
235-237


F5
i-Pr
6-Me
2-Me-4-Cl-Ph
172-174


F6
t-Bu
H
2-Me-3-Cl-Ph
218-220


F7
i-Pr
H
2-Me-3-Cl-Ph





*See Index Table L for 1H NMR data.













INDEX TABLE G













 












Compound
R2
R3
(R4)n
J
m.p. ° C.





G1 
H
i-Pr
4-Me
4-CF3-Ph
 121-123*


G3 
H
S—CH(Ph)Me
H
3-pyridinyl


G5 
H
i-Pr
4-Me
1-(2-Cl-3-Ph)-3-Br-5-pyrazolyl


G14
H
NMe2
4,6-Cl2
4,6-Cl2-3-NH2-2-pyridinyl
192-194


G15
Me
Me
4,6-Cl2
4,6-Cl2-3-NH2-2-pyridinyl
171-172


*See Index Table L for 1H NMR data













INDEX TABLE H













 









Compound
J
m.p. ° C.





H1
2-Me-4-Br-Ph
*





*See Index Table J for 1H NMR data.













INDEX TABLE I













 












Compound
R2
R3
(R4)n
J
m.p. ° C.





I6 (Ex. 4)
Me
Me
4-Me
1-(3-Cl-3-pyridinyl)-3-Cl-5-pyrazolyl
232-236


*See Index Table L for 1H NMR data.













INDEX TABLE J













 












Com-







pound
R2
R3
R4
J
m.p. ° C.





J1
H
i-Pr
Me
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
 174-176













INDEX TABLE K













 












Com-







pound
R2
R3
R4
J
m.p. ° C.





K3
H
Me
Me
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
185-190


K4
H
i-Pr
Me
1-(2-Cl-Ph)-3-CF3-5-pyrazolyl
160-162


*See Index Table L for 1H NMR data.
















INDEX TABLE L








1H NMR Partial Spectrum Data




(CDCl3 solution unless



Compd. No.
indicated otherwise)a









 1
10.63(s, 1H), 5.58(d, 1H)



 2
10.55(s, 1H), 5.60(s, 1H)



 3
10.55(s, 1H), 5.58(d, 1H)



 4
9.80(s, 1H), 5.60(d, 1H)



 5
9.68(s, 1H), 5.60(s, 1H)



 6
10.45(s, 1H), 5.60(d, 1H)



 7
9.93(s, 1H), 5.60(d, 1H)



 8
9.90(s, 1H), 5.59(d, 1H)



 9
9.83(s, 1H), 5.60(s, 1H)



10
9.78(s, 1H), 5.60(s, 1H)



11
10.57(s, 1H), 5.58(d, 1H)



12
10.46(s, 1H), 5.60(s, 1H)



13
9.85(s, 1H), 5.60(d, 1H)



14
9.82(s, 1H), 5.58(d, 1H)



15
9.76(s, 1H), 5.62(s, 1H)



16
9.68(s, 1H), 5.60(s, 1H)



C1
10.19(s, 1H), 5.72(d, 1H)



C2
10.23(s, 1H), 5.71(d, 1H)



C3
10.23(s, 1H), 5.66(s, 1H)



C4
9.50(s, 1H), 5.62(d, 1H)



C5
10.18(s, 1H), 5.67(s, 1H)



C6
10.41(s, 1H), 5.62(s, 1H)



C7
10.36(s, 1H), 5.66(s, 1H)



C8
9.56(s, 1H), 5.54(d, 1H)



C10
9.56(s, 1H), 5.53(d, 1H)



E1
10.10(s, 1H), 6.24(s, 1H)



E2
10.08(s, 1H), 6.30(s, 1H)



E3
8.36(m, 3H), 7.94(d, 1H), 7.79




(d, 2H), 4.36(m, 1H), 1.32(d, 6H)



E4
10.05, 1H), 6.16(d, 1H)



E7
7.75(d, 1H), 7.67(s, 1H)



E27
9.0(s, 1H), 6.2(m, 1H)



E28
9.25(s, 1H), 6.18(m, 1H)



E34
9.5(brs, 1H), 6.05(d, 1H)



E35
(DMSO-d6)10.9(s, 1H), 6.66(m, 1H)



E36
10.3(s, 1H)



F1
11.56(s, 1H), 8.41(d, 1H)



G1
11.97(s, 1H)



H1
5.56(d, 1H)







a1H NMR data are in ppm downfield from tetramethylsilane. Couplings are designated by (s)—singlet, (d)—doublet, (t)—triplet, (q)—quartet, (m)—multiplet, (dd)—doublet of doublets, (dt)—doublet of triplets, (brs)—broad singlet.






BIOLOGICAL EXAMPLES OF THE INVENTION
Test A
For evaluating control of diamondback moth (Plutella xylostella) the test unit consisted of a small open container with a 12-14-day-old radish plant inside. This was pre-infested with 10-15 neonate larvae on a piece of insect diet by use of a core sampler to remove a plug from a sheet of hardened insect diet having many larvae growing on it and transfer the plug containing larvae and diet to the test unit. The larvae moved onto the test plant as the diet plug dried out.
Test compounds were formulated using a solution containing 10% acetone, 90% water and 300 ppm X-77® Spreader Lo-Foam Formula non-ionic surfactant containing alkylarylpolyoxyethylene, free fatty acids, glycols and isopropanol (Loveland Industries, Inc.), unless otherwise indicated. The formulated compounds were applied in 1 mL of liquid through a SUJ2 atomizer nozzle with 1⁄8 JJ custom body (Spraying Systems Co.) positioned 1.27 cm (0.5 inches) above the top of each test unit. All experimental compounds in these tests were sprayed at 250 ppm and replicated three times. After spraying of the formulated test compound, each test unit was allowed to dry for 1 hour and then a black, screened cap was placed on top. The test units were held for 6 days in a growth chamber at 25° C. and 70% relative humidity. Plant feeding damage was then visually assessed based on foliage consumed.
Of the compounds tested the following provided very good to excellent levels of plant protection (ratings of 0-1, 10% or less feeding damage): 1, 2, 3, 4, 5, 6, 7, 8, 9, 12, 13, 15, 16, 19, 20, 21, 22, 23, 24, 30, 31, 32, 33, 34, 36, 37, 38, B1, B3, B5, B11, B12, B15, C1, C2, C3, C7, C9, C24, D1, D3, D4, D5, D6, D7, D8, D10, D11, D12, D13, D14, D18, D19, D20, D21, E5, E6, E7, E8, E9, E10, E11, E12, E13, E14, E15, E16, E17, E19, E20, E21, E22, G1, G2, G4, G5, G6, G7, G8, G9, G10, G11, G12, G13, J6, K1 and K2.
Test B
For evaluating control of fall armyworm (Spodoptera frugiperda) the test unit consisted of a small open container with a 4-5-day-old corn (maize) plant inside. This was pre-infested (using a core sampler) with 10-15 1-day-old larvae on a piece of insect diet.
Test compounds were formulated and sprayed at 250 ppm as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test A.
Of the compounds tested, the following provided excellent levels of plant protection (10% or less feeding damage): 30, 31, 32, 33, 34, 35, 36, B10, B11, B12, B13, B14, D1, D3, D7, D8, D10,D11, D14, D15, E5, E6, E7, E9, E10, E11, E12, E13, E22, G2, G4, G5, G6, G7, G9, G10, G11, G12, G13, J6 and K2.
Test C
For evaluating control of tobacco budworm (Heliothis virescens) the test unit consisted of a small open container with a 6-7 day old cotton plant inside. This was pre-infested (using a core sampler) with 8 2-day-old larvae on a piece of insect diet.
Test compounds were formulated and sprayed at 250 ppm as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test A.
Of the compounds tested, the following provided very good to excellent levels of plant protection (20% or less feeding damage): 31, 32, 33, 34, 35, 36, 37, B12, B13, B14, B15, D1, D4, D5, D6, D8, D10, D11, D12, D13, D14, D15, D18, D19, D20, D21, E5, E6, E7, E9, E10, E12, E15, E20, E21, E22, G2, G5, G6, G7, G8, G9, G10, G11, G12, and G13.
Test D
For evaluating control of beet armyworm (Spodoptera exigua) the test unit consisted of a small open container with a 4-5-day-old corn plant inside. This was pre-infested (using a core sampler) with 10-15 1-day-old larvae on a piece of insect diet.
Test compounds were formulated and sprayed at 250 ppm as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test A.
Of the compounds tested, the following provided very good to excellent levels of plant protection (20% or less feeding damage): 31, 32, 34, B13, B15, D1, D3, D4, D7, D8, D10, D11, D14, D19, E5, E6, E7, E9, E10, E15, E22, G1, G2, G4, G5, G6, G7, G9, G10, G11, G12, G13, D20, J6and K2.
Test E
For evaluating control of green peach aphid (Myzus persicae) through contact and/or systemic means, the test unit consisted of a small open container with a 12-15-day-old radish plant inside. This was pre-infested (using the cut leaf method) with 30-40 insects on each piece of leaf, and the soil was covered with a layer of sand.
Test compounds were formulated and sprayed at 250 ppm as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually assessed for insect mortality.
Of the compounds tested, the following resulted in at least 80% mortality: C48, E13, E14, E16, G4, G9,G10,G11 and G13.
Test F
For evaluating control of cotton melon aphid (Aphis gossypii) through contact and/or systemic means, the test unit consisted of a small open container with a 6-7-day-old cotton plant inside. This was pre-infested (using the cut leaf method) with 30-40 insects on each piece of leaf, and the soil was covered with a layer of sand.
Test compounds were formulated and sprayed at 250 ppm as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test E.
Of the compounds tested, the following resulted in at least 80% mortality: E9.

## Claims

1. A compound of Formula I, an N-oxide thereof or suitable salt thereof




wherein
A and B are both O;
J is selected from the group consisting of J-6, J-7, J-8, J-9, J-10, J-11, J-12 and J-13




K is, together with the two contiguous linking carbon atoms, a 5- or 6-membered heteroaromatic ring selected from the group consisting of







n is 1 to 3;
R1 is H; or C1-C6 alkyl;
R2 is H;
R3 is H; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6alkynyl, C3-C6 cycloalkyl, each optionally substituted with one or more substituents selected from the group consisting of halogen, CN, NO2, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylcarbonyl, C3-C6 trialkylsilyl;
each R4 is independently C1-C4 alkyl, C1-C4 haloalkyl, halogen, CN, NO2 or C1-C4 alkoxy, and one R4 group is attached to the K ring at the atom adjacent to the NR1C(=A)J moiety;
R5 is




V is N, CH, CF, CCl, CBr or CI;
each R6 and R7 is independently H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, halogen, CN, C1-C4 alkoxy, C1-C4 haloalkoxy or C1-C4 haloalkylthio; and
R9 is H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 alkenyl, C3-C6 haloalkenyl, C3-C6 alkynyl or C3-C6 haloalkynyl; provided R7 and R9 are not both H.

2. The compound of claim 1 wherein V is N.

3. The compound of claim 1 wherein V is CH, CF, CCl or CBr.

4. The compound of claim 2 or claim 3 wherein
R1 is H;
R2 is H;
R3 is C1-C4 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, OCH3 or S(O)pCH3;
each R4 is independently CH3, CF3, CN or halogen, and one R4 group is attached to the K ring at the atom adjacent to the NR1C(=A)J moiety;
R6 is C1-C4 alkyl, C1-C4 haloalkyl, halogen or CN;
R7 is H, CH3, CF3, OCH2CF3, OCHF2 or halogen; and
p is 0, 1 or 2.

5. The compound of claim 4 wherein R3 is C1-C4 alkyl; one R4 group is independently CH3, Cl, Br or I and is attached to the K ring at the atom adjacent to the NR1C(=A)J moiety; and a second optional R4 is H, F, Cl, Br, I or CF3.

6. The compound of claim 5 wherein J is J-6; R6 is Cl or Br; and R7 is halogen, OCH2CF3 or CF3.

7. The compound of claim 6 wherein V is N; R3 is methyl, ethyl, isopropyl or tertiary butyl; and R7 is Br, Cl, OCH2CF3 or CF3.

8. The compound of claim 5 wherein J is J-7; R6 is Cl or Br; and R9 is CF3, CHF2, CH2CF3 or CF2CHF2.

9. The compound of claim 5 wherein J is J-8; R6 is Cl or Br; and R7 is halogen, OCH2CF3 or CF3.

10. The compound of claim 5 wherein J is J-9; R6 is Cl or Br; and R7 is OCH2CF3 or CF3.

11. The compound of claim 5 wherein J is J-10; R6 is Cl or Br; and R9 is CF3, CHF2, CH2CF3 or CF2CHF2.

12. The compound of claim 5 wherein J is J-11; R6 is Cl or Br; and R7 is halogen, OCH2CF3 or CF3.

13. The compound of claim 5 wherein J is J-12; R6 is Cl or Br; and R7 is H, halogen or CF3, and R9 is H, CF3, CHF2, CH2CF3, or CF2CHF2.

14. The compound of claim 5 wherein J is J-13; R6 is Cl or Br; and R9 is H, CF3, CHF2, CH2CF3 or CF2CHF2.

15. The compound of claim 1 selected from the group consisting of:
4-[[[1-(2-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl]amino]-5-methyl-N-(1-methylethyl)-3-pyridinecarboxamide;
4-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-5-chloro-N-methyl-3-pyridinecarboxamide;
3-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-2,6-dichloro-N-methyl-4-pyridinecarboxamide;
2,6-dichloro-3-[[[1-(3-chloro-2-pyridinyl)-3-trifluoromethyl)-1H-pyrazol-5-yl]carbonyl]amino]-N-(1-methylethyl)-4-pyridinecarboxamide;
3-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-6-chloro-N,4-dimethyl-2-pyridinecarboxamide;
3-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-4,6-dichloro-N-methyl-2-pyridinecarboxamide; and
5-[[[3-Chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-N,6-dimethyl-4-pyrimidinecarboxamide.

16. A method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of claim 1.

17. The method of claim 16 further comprising a biologically effective amount of at least one additional compound or agent for controlling invertebrate pests.