UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

MEMORANDUM

Date: October 9, 2012

SUBJECT: Kresoxim-methyl:

PC Code: 129111

Decision No.: 468823

Petition No.: NA

Risk Assessment Type: NA

TXR No.: NA

MRID No.: NA

 

 

FROM: Shanna Recore, Industrial Hygienist

Toxicology and Epidemiology

Health Effect Division (7509P)

THROUGH: David Miller, Acting 

Toxicology and Epidemiology

Health Effects Division (7509P)

TO: Myron Ottley, Risk Assessor

Risk Assessment Branch

Health Effects Division (7509P

and

Katie Weyrauch, Chemical Review

Risk Management 

Pesticide Re-evaluation Division (7508P)

I. CONCLUSION

Based on the low frequency and 

does not appear to be a concern at this time that would warrant further 

Agency will continue to monitor the incident information and if a concern is triggered, additional 

analysis will be included in the risk assessment.

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

POLLUTION PREVENTION

: Review of Human Incidents

DP Barcode: D405758

Registration No.: NA

Regulatory Action: NA

Case No.: NA

CAS No.: 143390-89-0

40 CFR: NA

Shanna Recore, Industrial Hygienist

Toxicology and Epidemiology Branch

Health Effect Division (7509P)

Acting Branch Chief

Toxicology and Epidemiology Branch

Health Effects Division (7509P)

Risk Assessor

Risk Assessment Branch III

Health Effects Division (7509P)

, Chemical Review Manager

Risk Management & Implementation Branch V

evaluation Division (7508P)

Based on the low frequency and severity of incident cases reported for kresoxim

does not appear to be a concern at this time that would warrant further investigation

Agency will continue to monitor the incident information and if a concern is triggered, additional 

analysis will be included in the risk assessment.

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF CHEMICAL SAFETY AND

OLLUTION PREVENTION

Ver.Apr.08

reported for kresoxim-methyl, there 

investigation. The 

Agency will continue to monitor the incident information and if a concern is triggered, additional 
Page 2 of 3

II. ACTION REQUESTED

This review is intended to fulfill our requirement to docket summaries of incident data that were 

reported to the Agency, as well as to ensure human incident data and the Agricultural Health 

Study (AHS) are part of the problem formulation phase of registration review. Reports of 

adverse health effects allegedly due to a specific pesticide exposure (i.e., an “incident”) are 

largely self-reported and therefore, generally speaking, neither exposure to a pesticide or 

reported symptom (or the connection between the two) is validated or otherwise confirmed. 

Typically, causation cannot be determined based on incident data. However, incident 

information can be an important source of feedback to the Agency: incidents of severe outcome, 

or a suggested pattern or trend among less severe incidents, can signal the Agency to further 

investigate a particular chemical or product. Observational epidemiology studies relate the risk 

of disease, e.g., cancer, and exposure to an agent such as a pesticide product in the general 

population or specific sub-groups like pesticide applicators. 

III. BACKGROUND

For this evaluation, the OPP Incident Data System (IDS) was utilized to retrieve pesticide 

incident data on the active ingredient kresoxim-methyl (PC Code 129111). Kresoxim-methyl is

a fungicide registered to control powdery mildew on the following greenhouse-grown 

ornamental crops: ageratum, dahlias, dianthus, dusty miller, gazania, geraniums, marigolds,

pansies, portulaca, snapdragons, spirea, spengril, verbena, vinca, zinnia, poinsettias, roses, cut 

flowers, oak trees, and dogwood trees. The purpose of the database search is to identify potential 

patterns in the frequency and severity of the health effects attributed to kresoxim-methyl

exposure. The IDS includes reports of alleged human health incidents from various sources, 

including mandatory Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) Section 

6(a)(2) reports from registrants, other federal and state health and environmental agencies, and 

individual consumers. Since 1992, OPP has compiled these reports in IDS. IDS contains reports 

from across the U.S. and most incidents have all relevant product information recorded. Reports 

submitted to the IDS represent anecdotal reports or allegations only, unless otherwise stated in 

the report. 

The AHS is a high quality, prospective epidemiology study evaluating the link between pesticide 

use and various health outcomes including cancer. The AHS includes private and commercial 

pesticide applicators and their spouses. If there are AHS findings relevant to a particular 

pesticide going through registration review, the Agency will ensure they are considered in the 

problem formulation/scoping phase of the process and, if appropriate, fully reviewed in the risk 

assessment phase of the process. The AHS includes information on use of 50 different pesticide 

active ingredients commonly used in agriculture.

IV. RESULTS/DISCUSSION

IDS records incidents resulting in higher severity outcomes in more detail, in a module called the 

Main IDS module. This system stores incident data for death, major and moderate incidents, and 

it includes more details about the location, date and nature of the incident. Main IDS incidents 

involving only one pesticide are considered to provide more certain information about the 
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potential effects of exposure from the pesticide. The less severe human incidents (minor, 

unknown, or no effects outcomes) are reported by registrants as counts called aggregate 

summaries and are recorded in a separate module called Aggregate IDS. 

In Aggregate IDS, from January 1, 2007 to June 13, 2012, there were 2 reported incidents 

involving kresoxim-methyl. 

For the Main IDS, from January 1, 2007 to June 13, 2012, there were no incidents reported for 

kresoxim-methyl in the database.

Kresoxim-methyl is not included in the AHS, and therefore this study does not provide 

information for this report.

Based on the low frequency and severity of incident cases reported for kresoxim-methyl, there 

does not appear to be a concern at this time that would warrant further investigation. The 

Agency will continue to monitor the incident information and if a concern is triggered, additional 

analysis will be included in the risk assessment.