**UNITED STA TES ENVIRONMENTA**  **L PROTECTION A GENCY** 

**MEMORANDUM Date:**  October 9, 2012 **SUBJECT:** Kresoxim
- methyl : **PC Code:** 129111 **Decision No.:** 468823 **Petition No.:** NA **Risk Assessment Type:** NA **TXR No.:** NA **MRID No.:** NA **FROM:** Shanna Recore, Industrial Hy gienist Toxicology

and Epidemiology Health Effect Division (7509P) **THROUGH:** David Miller , Acting

Toxicology

and Epidemiology Health Effects Division (7509P) **TO:** My

ron Ottley , Risk Assessor Risk Assessment Branch Health Effects Division (7509P and K atie Wey

rauch , Chemical Review Risk Management Pesticide Re
- evaluation Division (7508P) **I. CONCLUSION**  Based on the low frequency and does not appear to be a concern at this time that would warrant further Agency will continue to monitor the incident information and if a concern is triggered, additional anal ys is will be included in the risk assessment.

Page 1 of 3 **UNITED STA**

**TES ENVIRONMENTA L PROTECTION A** **GENCY WA** **SHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND** 

**P OLLUTION PREVENTION** 

: Review of Human Incidents

**DP Barcode:** D 405758 **Registration No.:** NA **Regulatory Action:** NA **Case No.:** NA **CAS No .:**  143390
- 89
- 0 **40 CFR:** NA Shanna Recore, Industrial Hy gienist Toxicology

and Epidemiology Branch Health Effect Division (7509P)

Acting Branch Chief Toxicology

and Epidemiology Branch Health Effects Division (7509P)

Risk Assessor Risk Assessment Branch II I Health Effects Division (7509P )

, Chemical Review Manager Risk Management & Implementation Branch V

evaluation Division (7508P)
Based on the low frequency and severity

of incident cases reported for kresoxim does not appear to be a concern at this time that would warrant further investigation Agency will continue to monitor the incident information and if a concern is triggered, additional anal ys is will be included in the risk assessment.

**UNITED STA**

**TES ENVIRONMENTA L PROTECTION A** **GENCY**

**OFFICE OF CHEMICAL SAFETY AND**

**OLLUTION PREVENTION**

Ver.Apr.08

reported for kresoxim
- methyl , there

investigation
. The Agency will continue to monitor the incident information and if a concern is triggered, additionalPage 2 of 3

**II. ACTION REQUESTED**  This review is intended to fulfill our requirement to docket summaries of incident data that were reported to the Agency , as well as to ensure human incident data and the Agricultural Health Study (AHS) are part of the problem formulation phase of registration review. Reports of adverse health effects allegedl y due to a specific pesticide exposure ( i.e. , an “incident”) are largel y self

- reported and therefore, generall y speaking, neither exposure to a pesticide or reported s ymptom (or the connection between the two) is validated or otherwise confirmed
. Ty pically , causat ion cannot be determined based on incident data. However, incident information can be an important source of feedback to the Agency : incidents of severe outcome, or a suggested pattern or trend among less severe incidents , can signal the Agency to furthe r investigate a particular chemical or product. Observational epidemiology studies relate the risk of disease, e.g. , cancer, and exposure to an agent such as a pesticide product in the general population or specific sub
- groups like pesticide applicators. **III. BACKGROUND**  For this evaluation, the OPP Incident Data Sy stem (IDS) w a s utilized to retrieve pesticide incident data on the active ingredient kresoxim
- methyl (PC Code 129111 )
. Kresoxim
- methyl is a fungicide registered to control powdery mildew on the following greenhouse
- grown ornamental crops: ageratum, dahlias, dianthus, dusty miller, gazania, geraniums, marigolds, pansies, portulaca, snapdragons, spirea, spengril, verbena, vinca, zinnia, poinsettias, roses, cut flowers, oak trees, and dogwood tr ees. The purpose of the database search is to identify potential patterns i n the frequency

and se verit y of the health effects attributed to kresoxim
- methyl exposure. The IDS includes reports of alleged human health incidents from various sources, including mandatory

Federal Insecticide, Fungicide and Ro denticide Act (FIFRA) Section 6(a) (2) reports from registrants, other federal and state health and environmental agencies , an d individual consumers. Since 1992, OPP has compile d these reports in IDS. IDS contain s reports from across the U.S. and most incidents have all relevant product information recorded. Reports submitted to the IDS represent anecdotal reports or allegations only , unless otherwise stated in the report. The AHS is a high quality , prospective epidemiology study evaluating the link between pesticide use and various health outcomes including cancer. The AHS includes private and commercial pesticide applicators and their spouses . If there are AHS findings relevant to a particular pesticide going through registration review, the Agency will ensure they are considered in the problem formulation/scoping phase of the process and, if appropriate, full y reviewed in th e risk assessment phase of the process
. The AHS includes information on use of 50 different pesticide active ingredients commonly used in agriculture
. **IV. RESULTS/DISCUSSION** IDS records incidents resulting in high er severity outcomes in more detail, in a module called the Main IDS module . This sy stem stores incident data for death, major and moderate incidents, and it includes more details about the location, date and nature of the incident. Main IDS incidents involving only

one pesticide are considere d to provide more certain information about thePage 3 of 3

potential effects of exposure from the pesticide
. The less severe human incidents (minor, unknown, or no effects outcomes) are reported b y registrants as counts called aggregate summaries and are recorded in a separate module called Aggregate IDS
. In A ggregate IDS , from January 1, 200 7 to June 13 , 2012 , there were 2 reported incidents involving kresoxim
- methyl
. For the M ain IDS, from January 1, 200 7 to June 13 , 2012 , there were no incidents reported for kresoxim
- methyl in the database. Kresoxim
- methyl is not included in the AHS, and therefore this study does not provide information for this report. Based on the low frequency and severity

of incident cases reported for kresoxim
- methyl , the re does not appear to be a concern at this time that would warrant further investigation
. The Agency will continue to monitor the incident information and if a concern is triggered, additional anal ys is will be included in the risk assessment.