Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 1 of 14 UNITED STATES ENVIRONMENTA L PROTECTION A GENCY

WASHINGTON, D.C. 20460 OFFICE OF PREVENTION, PESTICIDE S s

AND TOXIC SUBSTANCES

ME MORANDUM Date: 04 - MAR - 20 10 SUBJECT: Halosulfuron - methyl Acute and Chronic Aggregate Dietary (Food and Drinking Water ) Exposure and Risk Assessments for the Section 3 Registration Action on Pea and Bean, Succulent Shelled, Subgroup 6B; Vegetable, Tub erous and Corm, Subgroup 1C; Rhubarb; Bushberry Subgroup 13 - 07B ; Apple; and Okra. PC Code: 128721 DP Barcode: D36705 9 Decision No.: 414896 Registration Nos. : 81880 - 18 and 81880 - 2 Petition No.: 9E7577 Regulatory Action: Section 3 Registration Risk Assessment Type: NA Case No.: NA T XR No.: NA CAS No.: 100784 - 20 - 1 MRID Nos.: NA 40 CFR: §180.479 FROM : Debra Rate, Ph.D., Biologist

Alternative Risk Integration and Assessment (ARIA) Team Risk Integration, Minor Use and Emergency Response Bran ch (RIMUERB) Registration Division (RD; 7505P) THROUGH: Thurston Morton , Chemist

Breann Hanson, Biologist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division ( HED; 7509P) and William Cutchin, Acting Senior Branch Scientist ARIA/R IMUERB/RD (7505P) TO: Whang Phang, Toxicologist

Risk Assessment Branch III (RABIII) HED ( 7509P) Vickie Walters/James Tompkins (RM Team #25) Herbicide Branch (HB) /RD (7505P)Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 2 of 14 Executive Summary A cute and chronic aggregate dietary (food and drink ing water) exposure and risk assessments were conducted using the Dietary E xposure Evaluation Model DEEM FCIDTM, Version 2.03 , which use s food consumption data from the U.S. Department of Agriculture’s (USDA’s) Continuing Survey s of Food Intakes by Individu als (CSFII) from 1994 - 1996 and 1998 . The anal ys es were performed to support a Section 3 request for new use s on p ea and b ean, s ucculent s helled, Subgroup 6B; v egetable, tuberous and c orm, Subgroup 1C; r

hubarb; b ushberry

Subgroup 13 - 07B ; apple; and okra. Acute Dietary ( Food and Drinking Water) Exposure Results and Characterization An acute dietary

(food and drinking water) exposure assessment was conducted for the proposed use s on p ea and b ean, s ucculent s helled, Subgroup 6B; v egetable, tuberous and c orm, Subgroup 1C; r

hubarb; b ushberry

Subgroup 13 - 07B ; apple; and okra; all established uses ; and drinking water. An unrefined assessment was conducted. The residue levels used in the assessment for all commodities were the established or recommended tol erance levels (DP#367058, D. Rate , 03/03/2010 ) . The assessment was conducted using the assumption that 100% of the crop was treated (100%CT) . Default (DEEM 7.81) processing factors were used unless processing studies were available . For some commodities , processing studies showed that residues do not concentrate upon processing ( i.e. tomato paste , tomato puree , potato flour and potato granules/flakes ). Estimated concentrations of halosulfuron - methyl in drinking water from use on rice, which reflected the highest use rate, were provided by the Environmental Fate and Effects Division ( EFED ) and incorporated directly into the acute assessment. A Tier 1 drinking water assessment for the use on rice was performed using the FQPA Index Reservoir Screening To ol ( FIRST ) modeling. The acute estimated drinking water concentration (acute EDWC ) of halosulfuron - methyl is not expected to exceed 59.2 ppb (0.0592 ppm). The acute dietary

(food and drinking water) exposure to halosulfuron - methyl is below ARIA ’s level of concern for the general U.S. population and all population subgroups. For the general U.S. population, an appropriate dose/endpoint attributable to a single dose was not observed in the reviewed oral toxicity studies. T he acute dietary exposure estim ate at the 95 th percentile is <1 % of the aPAD for females 13 - 49 y ears old, the only population subgroup of concern. Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization A chronic dietary

(food and drinking water) exposure asses sment was conducted for the recommended use s on p ea and b ean, s ucculent s helled, Subgroup 6B; v egetable, tuberous and c orm, Subgroup 1C; r hubarb; b ushberry

Subgroup 13 - 07B ; apple; and okra; all established uses; and drinking water. An unrefined assessment was conducted. The residue levels used in the assessment for all commodities were the established or recommended tolerance levels. The assessment was conducted using the assumption ofHalosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 3 of 14 100% CT . Default (DEEM 7.81) processing factors were used unless pro cessing studies were available. For some commodities, processing studies showed that residues do not concentrate upon processing (i.e. tomato paste, tomato puree, potato flour and potato granules/flakes) . Estimated concentrations of halosulfuron - methyl in drinking water from use on rice, which reflected the highest use rate, were provided by EFED and incorporated directl y into the chronic assessment. A Tier 1 drinking water assessment for the use on rice was performed using FIRST modeling. The annual mean (chronic) estimated drinking water concentration (chronic EDWC ) of halosulfuron - methyl is not expected to exceed 59.2 ppb (0.0592 ppm). The chronic dietary

(food and drinking water) exposure to halosulfuron - methyl is below ARIA ’s level of concern for the general U.S. population and all population subgroups. The chronic dietary

exposure estimates are 2 % of the cPAD for the general U.S. population and 5 % of the cPAD for all infants (<1 y ear old), the most highly exposed population subgroup. C ancer Die tary (Food and Drinking Water) Exposure Results and Characterization The HIARC classified halosulfuron - methyl as “not likely to be a human carcinogen ;” therefore, quantification of human cancer risk is not required. I. Introduction Dietary risk assessm ent incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health e ffects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty

or safet y factors. For acute and non - cancer chronic exposures, ARIA is con cerned when estimated dietary risk exceeds 100% of the PAD. ARIA is generally concerned when estimated cancer risk exceeds one in one m illion . References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pestici des web site: “Available In formation on Assessing Exposure from Pesticides, A User’s Guide,” 21 - JUN - 2000, web link: http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day - 12/606 1.pdf ; or see SOP 99.6 ( 20 - AUG - 1999 ). The most recent dietary

risk assessment for halosulfuron - methyl was conducted b y Nancy Dodd ( DP # 359457, 05/29/2009 ) .Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 4 of 14 II. Residue Information Halosulfuron - methyl Use: Interregional R esearch Project No. 4 (IR - 4) h as proposed new uses of halosulfuron methyl on: apple; bushberry S ubgroup 13 - 07B; okra; succulent - shelled pea and bean S ubgroup 6B; dried shelled pea and bean, except soy bean, S ubgroup 6C; rhubarb; and tuberous and corm vegetable S ubgroup 1C. A tolerance of 0.05 ppm on each of these commodities or crop groups/subgroups is proposed. ARIA has recomm end ed in favor of th ese tolerance s, with the exception of dried shelled pea and bean, except soy bean, S ubgroup 6C . The existing individual tolerance on bean, dry seed (0.05 ppm) was included in the assessment. Permanent tolerances are established under §180.479(a)(1) for residues of halosulfuron methyl and its metabolites determined as 3 - chloro - 1 - methyl - 5 - sulfamo yl py razole - 4 - carbox yl ic acid, expressed as halosu lfuron - methyl equivalent s, in/on the meat b yproducts of cattle, goat, hog, horse, and sheep at 0.1 ppm. Tolerances are established under §180.479(a)(2) for residues of halosulfuron - methyl in/on a variety of field, fruit, and vegetable crop commodities, at levels ranging from 0.05 to 2.0 ppm. A time - limited tolerance for sweet potato , established under §180.479(b) , has expired (expiration dat e 12/31/08). T he Metabolism Committee has concluded that the residue of concern in target plants, rotational plants , and livestock is halosulfuron - methyl (G. J. Herndon, No DP# s , 9/1 6 / 19 93 and 5/21/ 19 96). Although HED concluded that the residue of concern in livestock is halosulfuron - methyl , tolerances for residues in livestock commodities are expressed in terms of halosulfuron - methyl and its metabolites determined as 3 - chloro - 1 - methyl - 5 - sulfamoylpy

razole - 4 - carbox yl ic acid , expressed as halosulfuron - methyl equivalents , because the enforcement method for livestock commodities quantifies the parent and metabolites cont aining the 3 - chlorosulfonamide moiety (3 - CSA) by converting residues to 3 - CSA . The residue of concern in water is halosulfuron - methyl. The parent is mobile and persistent. Residue Data used for Acute and Chronic Assessments: These acute and chronic a ssessments are unrefined assessments using tolerance - level residues and 100% CT for all commodities with proposed and established tolerances . No change s in the established livestock t olerances are being recommended as a result of the proposed uses. Defau lt ( DEEM 7.81 ) processing factors were used unless processing studies were available. The processing factors which were used were 1.5 X for field corn sy rup, 14.3 X for dried tomato, 1.5 X for tomato juice , 8.0X for dried apple, and 1.3X for apple juice .Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 5 of 14 Fo r some commodities, processing studies showed that residues do not concentrate upon processing ( i.e. tomato paste, tomato puree, potato flour and potato granules/flakes ). III. Drinking Water Data The drinking water residues used in the dietary risk asses sment were provided by EFED in the following memorandum: “ Halosulfuron - methyl Drinking Water Assessment for Additional Food Uses (including Proposed Use on Soy bean)” ( D P#358032 , M. Barrett, 5/ 27 / 20 09 ) and incorporated directl y into this dietary assessment. Water residues were incorporated in the DEEM - FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” Since the application rates associated with the proposed new uses did not exceed the application rate on rice (0. 125 lb ai/A), a new drinking water assessment was not required for this dietary anal ys is. The Tier I EDWCs for halosulfuron - methyl are based on a maximum annual application rate of 0.125 lb ai/A for rice. The two screening models, FIRST and Scre ening Concentrations in Ground Water ( SCI - GROW ) , were used for estimatin g EDWCs of halosulfuron - methyl. Estimates for halosulfuron - methyl in surface water based on the FIRST model for rice are 59.2 ppb for acute and chronic concentrations. It should be n oted that the drinking water estimate based on rice application is an upper bound estimate. The estimate for halosulfuron - methyl in groundwater based on the SCI - GROW model result is 0.065 ppb. Table 1 summarizes the results. Table 1 . Summary of Estimat ed Surface Water and Groundwater Concentrations fo r Halosulfuron - me thyl. Surface Water Conc., ppb a Groundwater Conc., ppb b Ac ute 59.2 0.065 Chronic (non - cancer) 59.2 0.065 a From the FIRST model. b From the SCI - GROW model. Halosulfuron - methyl, li ke most other sulfonylurea herbicides, is extremel y mobile with a median Koc of 104 g/mL and K f (Freundlich partition) values ranging from 0.32 to 3.6 in four test soils. Its persistence in soil and water appears to be highl y variable. Halosulfuron - methyl has the potential to leach to groundwater, and also presents concerns for transport to surface water b y runoff. The FIRST and SCI - GROW model s and their description s are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/ . IV. DEEM - FCIDTM Program and Consumption Information Halosulfuron - methyl acute and chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the F ood Commodity Intake Database DEEM - FCIDTM, Version 2.03 , which incorporates consumption data fromHalosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 6 of 14 USDA’s Continuing Survey s of Food Intakes by Individuals (CSFII), 1994 - 1996 and 1998. The 1994 - 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as in dividual consumption events. Based on anal ys is of the 1994 - 96, 98 CSFII consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 y ear old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50+ ye ars old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or f ood - form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day

and as a percent of the cPAD. This procedure is perf ormed for each population subgroup. For acute exposure assessments, individual one - day food consumption data are used on an individual - by - individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy , per capita exposure and risk are reported for all tiers of anal ys is. However, for unrefined assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment. V. Toxicologic al Information The risk assessment team confirmed endpoints that were previously selected and confirmed the reduction to 1X of the FQPA Safet y Factor for all population subgroups (DP# 358031 , W . Phang , 06 / 30 /200 9 ). H alosulfuron - methyl is classified as “ not likel y to be carcinogenic to humans” based on a lack of evidence of carcinogenicity in male and female mice and rats. Therefore, halosulfuron - methyl is not expected to pose a cancer risk for humans.Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 7 of 14 Toxicological endpoints for use in dietary exposure risk assessment s are summarized in Table 2 below . Table 2 . Summary of Toxicolo gi cal Doses and Endpoints for Halosulfuron - methyl for Use in Dietary Exposure Risk Assessments Exposure/ Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD, PA D,

Level of Concern Study and Toxicological Effects Ac ute Dietary (Fem ales 13 - 49 years of age) NOAEL=

50 mg/kg/day UF A= 10x

UF H = 10x FQPA SF= 1x Ac ute RfD =

0.5 mg/kg/day aPAD =0.5 mg/kg/day Developm ental Toxicity - Rabbit

LOAEL = 150 mg/kg/day based on decreased mean litter size, increased number of resorptions (total and per dam) and increased postimplantation loss. (developmental toxicity) Ac ute Dietary (General Population , including Infants and Children) N/A N/A N/A No appropriate dose/endpoint sele cted.

Chronic Dietary (All Populations) NOAEL=

10 mg/kg/day UF A= 10x

UF H = 10x FQPA SF= 1x Chronic

RfD = 0.1 mg/kg/day cPAD = 0.1 mg/kg/day Chronic Toxicity - Dog

LOAEL = 40 mg/kg/day based on decreased body weight gains in females. Cancer (oral, derma l, inhalation) Classification: “ not likely to be carcinogenic to hum ans ” by the oral route, based on no

evidence of carcinogenicity from studies in rats and mice . Point of Departure (POD) = A data point or an estimated point that is derived from observed dose - response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (int er species). UF H = potential variation in sensitivity among members of the human population (intra species). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable. V I . Results/Discussion As stated above, for acute and chronic dietary assessments, ARIA is concerned when dietary risk exceeds 1 00% of the PAD. The DEEM - FCID  analy ses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 3 are for the general U.S. Population, all infants (<1 y ear old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, females 13 - 49, adults 20 - 49, and adults 50+ ye ars. Resu lts of Acute Dietary

(Food and Drinking Water) Exposure Anal ys isHalosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 8 of 14 The results of the acute (food and drinking water) dietary exposure anal ys is ar e reported in Table 3 below . T he acute dietary exposure estimate at the 95 th percentile is <1 % of the aPAD for females 13 - 49 y ears old, the onl y population subgroup of concern. Results of Chronic Dietary (Food and Drinking Water) Exposure Analy sis The results of the chronic dietary (food and drinking water) exposure anal ysis are reported in Table 3 below. T he chronic dietary (food and drinking water) exposure to halosulfuron - methyl is below ARIA ’s level of concern for the general U.S. population and all population subgroups. The chronic dietary exposure estimates are 2 % of the cPAD for the general U.S. popu lation and 5 % of the cPAD for all infants (<1 y ear old), the most highly

exposed population subgroup. Table 3. Summary of Dietary Exposure and Risk for Halosulfuron - methyl. Population Subgroup Ac ute Dietary (95th Percentile) Chronic Dietary Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD* General U.S. Population

N/A N/A 0.001705 2 All Infants (< 1 year old) 0.005059 5 Children 1 - 2 y ears old 0.003157 3 Children 3 - 5 y ears old 0.002823 3 Children 6 - 12 y ears old 0.0 01859 2 Youth 13 - 19 y ears old 0.001327 1 Adults 20 - 49 y ears old 0.001511 2 Adults 50+ years old 0.001558 2 Fem ales 13 - 49 years old 0.003401 <1 0.001503 2 The population subgroup with the highest estimated exposure/risk is bolded. VI I . Characte rization of Inputs/Outputs An unrefined assessment was conducted. The residue levels used in the assessment for all commodities were the established or recommended tolerance levels. The assessment was conducted using the assumption that 100% of the crop was treated. Default (DEEM 7.81) processing factors were used unless processing studies were available . For some commodities, processing studies showed that residues do not concentrate upon processing ( i.e. tomato paste, tomato puree, potato flour and p otato granules/flakes ).Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 9 of 14 The assessment could be refined with percent crop treated estimates , anticipated residues, or monitoring data. Since risk estimates are well below ARIA ’s level of concern, a more highl y refined analysis is not needed at this tim e. VIII. Conclusions Acute and chronic dietary exposure assessments were conducted for the proposed uses on p ea and b ean, s ucculent s helled, Subgroup 6B; v egetable, tuberous and c orm, Subgroup 1C; r hubarb; b ushberry

Subgroup 13 - 07B ; apple; and okra . The anal ys es were unrefined assessments, using the proposed or established tolerances for all commodities , using the assumption of 100% CT, and d efault (DEEM 7.81) processing factors when appropriate . For both of the acute and chronic assessments, the general U .S. population and all p opulation subgroups have risk estimates which are below ARIA ’s level of concern . IX. List of Attachments Attachment 1: Acute and Chronic Foo d plus Water Residue Input File Attachment 2: Acute Results File Attachment 3 : Chro nic Results File cc: D. Rate , W. PhangHalosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 10 of 14 Attachment 1: Acute and Chronic Food plus Water Residue Input File U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for HALOSULFURON - METHYL 1994 - 98 data Residue file: C: \ Documents and Settings \ drate \ Desktop \ Halosulfuron \ DEEM \ acute & chronic 128721.R98 Adjust. #2 NOT used Analysis Date 02 - 17 - 2010 Resid ue file dated: 02 - 17 - 2010/13:45:22/8 Reference dose (RfD) = 0.1 (NOEL) = 10 mg/kg bw/day Comment:Acute is only for Females 13 - 49 yrs

-------------------------------------------------------------------------------- Food Crop Residue Adj.Factors Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ - ----- ------- 14000030 14 Almond 0.050000 1.000 1.000 8F4937 14000031 14 Almond - babyfood 0.050000 1.000 1.000 14000040 14 Almond, oil 0.050000 1.000 1.0 00 8F4937 14000041 14 Almond, oil - babyfood 0.050000 1.000 1.000 11000070 11 Apple, fruit with peel 0.050000 1.000 1.000 9E7577 11000080 11 Apple, peeled fruit 0.050000 1.000 1.000 9E7577 11000081 11 Apple, peeled fruit - babyfood 0.050000 1.000 1.000 9E7577 11000090 11 Apple, dried 0.050000 8.000 1.000 9E7577 11000091 11 Apple, dried - babyfood 0.050000 8.000 1.000 9E7577 11000100 11 Apple, juice 0.050000 1.300 1.000 9E7577 11000101 11 Apple, juice - babyfood 0.050000 1.300 1.000 9E7577 11000110 11 Apple, sauce 0.050000 1.000 1.0 00 9E7577 11000111 11 Apple, sauce - babyfood 0.050000 1.000 1.000 9E7577 01030150 1CD Arrowroot, flour 0.050000 1.000 1.000 9E7577 01030151 1CD Arrowroot, flour - babyfood 0.050000 1.000 1 .000 9E7577 01030170 1CD Artichoke, Jerusalem 0.050000 1.000 1.000 9E7577 95000190 O Asparagus 0.800000 1.000 1.000 1F6229 09020210 9B Balsam pear 0.500000 1.000 1.000 06030300 6C Bean, black, seed 0.050000 1.000 1.000 06020310 6B Bean, broad, succulent 0.050000 1.000 1.000 9E7577 06030320 6C Bean, broad, seed 0.050000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.050000 1.000 1.000 9E7577 06030340 6C Bean, cowpea, seed 0.050000 1.000 1.000 06030350 6C Bean, great northern, seed 0.050000 1.000 1.000 06030360 6 C Bean, kidney, seed 0.050000 1.000 1.000 06020370 6B Bean, lima, succulent 0.050000 1.000 1.000 9E7577 06030380 6C Bean, lima, seed 0.050000 1.000 1.000 06030390 6C Bean, mung, seed 0.050000 1.000 1.000 06030400 6C Bean, navy, seed 0.050000 1.000 1.000 06030410 6C Bean, pink, seed 0.050000 1.000 1.000 06030420 6C Bean, pinto, seed 0.050000 1.000 1.000 06010430 6A Bean, snap, succulent 0.050000 1.000 1.000 06010431 6A Bean, snap, succulent - babyfood 0.050000 1.000 1.000 21000460 M Beef, meat byproducts 0.1 00000 1.000 1.000 3F4193 21000461 M Beef, meat byproducts - babyfood 0.100000 1.000 1.000 21000480 M Beef, kidney 0.100000 1.000 1.000 3F4193 21000490 M Beef, liver 0.10000 0 1.000 1.000 3F4193 21000491 M Beef, liver - babyfood 0.100000 1.000 1.000 13020570 13B Blueberry 0.050000 1.000 1.000 9E7577 13020571 13B Blueberry - babyfood 0.050000 1.000 1.000 9E7577 14000590 14 Brazil nut 0.050000 1.000 1.000 8F4937 14000680 14 Butternut 0.050000 1.000 1.000 09010750 9A Cantaloupe 0.100000 1.00 0 1.000 0E6206 09010800 9A Casaba 0.100000 1.000 1.000 0E6206 14000810 14 Cashew 0.050000 1.000 1.000 8F4937 01030820 1CD Cassava 0.050000 1. 000 1.000 9E7577 01030821 1CD Cassava - babyfood 0.050000 1.000 1.000 9E7577 09020880 9B Chayote, fruit 0.500000 1.000 1.000 14000920 14 Chestnut 0.050000 1.000 1.000 8F4937 06030980 6C Chickpea, seed 0.050000 1.000 1.000 06030981 6C Chickpea, seed - babyfood 0.050000 1.000 1.000 06030990 6C Chickpea, flour 0.050000 1.000 1.000 09021020 9B Chinese waxgourd 0.500000 1.000 1.000 15001200 15 Corn, field, flour 0.050000 1.000 1.000 6F4661Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 11 of 14 15001201 15 Corn, field, flour - babyfood 0.050000 1.000 1.000 150012 10 15 Corn, field, meal 0.050000 1.000 1.000 6F4661 15001211 15 Corn, field, meal - babyfood 0.050000 1.000 1.000 15001220 15 Corn, field, bran 0.050000 1.000 1.000 6F4661 15001230 1 5 Corn, field, starch 0.050000 1.000 1.000 6F4661 15001231 15 Corn, field, starch - babyfood 0.050000 1.000 1.000 15001240 15 Corn, field, syrup 0.050000 1.500 1.000 6F4661 15001241 15 Corn, field, syrup - babyfood 0.050000 1.500 1.000 15001250 15 Corn, field, oil 0.050000 1.000 1.000 6F4661 15001251 15 Corn, field, oil - babyfood 0.050000 1.000 1.000 15001260 15 Corn, pop 0.050000 1.000 1.000 6F4661 15001270 15 Corn, sweet 0.050000 1.000 1.000 6F4661 15001271 15 Corn, sweet - babyfood 0.050000 1.000 1.000 95001280 O Cottonseed, oi l 0.050000 1.000 1.000 8F4937 95001281 O Cottonseed, oil - babyfood 0.050000 1.000 1.000 09021350 9B Cucumber 0.500000 1.000 1.000 0E6085 13021360 13B Currant 0.050000 1.000 1.000 9E7577 13021370 13B Currant, dried 0.050000 1.000 1.000 9E7577 01031390 1CD Dasheen, corm 0.050000 1.000 1.000 9E7577 08001480 8 Eggplant 0.050000 1.000 1.000 13021490 13B Elderberry 0.050000 1.000 1.000 9E7577 14001550 14 Filbert 0.050000 1.000 1.000 8F4937 14001560 14 Filbert, oil 0.050000 1.000 1.000 01031660 1CD Ginger 0.050000 1.000 1.000 9E7577 01031661 1CD Ginger - babyfood 0.050000 1.000 1.000 9E7577 01031670 1CD Ginger, dried 0.050000 1.000 1.000 9E7577 23001700 M Goat, meat byproducts 0.100000 1.000 1.000 23001720 M Goat, kidney 0.100000 1.000 1.000 23001730 M Goat, liver 0.100000 1.000 1.000 13021740 13B Gooseberry 0.050000 1.000 1.000 9E7577 06031820 6C Guar, seed 0.050000 1.000 1.000 06031821 6C Guar, seed - babyfood 0.050000 1.000 1.000 14001850 14 Hickory nut 0.050000 1.000 1.000 09011870 9A Honeydew melon 0.100000 1.000 1.000 0E6206 13021910 13B Huckleberry 0.050000 1.000 1.000 9E7577 14002130 14 Macadamia nut 0.050000 1.000 1.000 8F4937 08002340 8 Okra 0.050000 1.000 1.000 9E7577 06022550 6B Pea, succulent 0.050000 1.000 1.000 9E7577 06022551 6B Pea, succulent - babyfood 0.050000 1.000 1.000 9E7577 06022590 6B Pea, pigeon, succulent 0.050000 1.000 1.000 9E7577 14002690 14 Pecan 0.050000 1.00 0 1.000 8F4937 08002700 8 Pepper, bell 0.050000 1.000 1.000 08002701 8 Pepper, bell - babyfood 0.050000 1.000 1.000 08002710 8 Pepper, bell, dried 0.050000 1.000 1.0 00 08002711 8 Pepper, bell, dried - babyfood 0.050000 1.000 1.000 08002720 8 Pepper, nonbell 0.050000 1.000 1.000 08002721 8 Pepper, nonbell - babyfood 0.050000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.050000 1.000 1.000 14002820 14 Pistachio 0.050000 1.000 1.000 8F4937 25002920 M Pork, meat byproducts 0.100000 1.000 1.000 3F4193 25002921 M Pork, meat byproducts - babyfood 0.100000 1.000 1.000 25002940 M Pork, kidney 0.100000 1.000 1.000 3F4193 25002950 M Pork, liver 0.100000 1.000 1.000 3F4193 01032960 1C Pota to, chips 0.050000 1.000 1.000 9E7577 01032970 1C Potato, dry (granules/ flakes) 0.050000 1.000 1.000 9E7577 01032971 1C Potato, dry (granules/ flakes) - b 0.050000 1.000 1.000 9E7577 01032980 1C Po tato, flour 0.050000 1.000 1.000 9E7577 01032981 1C Potato, flour - babyfood 0.050000 1.000 1.000 9E7577 01032990 1C Potato, tuber, w/peel 0.050000 1.000 1.000 9E7577 01032991 1C Potato, tuber, w/peel - babyfood 0.050000 1.000 1.000 9E7577 01033000 1C Potato, tuber, w/o peel 0.050000 1.000 1.000 9E7577 01033001 1C Potato, tuber, w/o peel - babyfood 0.050000 1.000 1.000 9E7577 09023080 9B Pumpkin 0.500000 1.000 1.000 0E6085 09023090 9B Pumpkin, seed 0.500000 1.000 1.000 04023220 4B Rhubarb 0.050000 1.000 1.000 9E7577 15003230 15 Ri ce, white 0.050000 1.000 1.000 8F4937 15003231 15 Rice, white - babyfood 0.050000 1.000 1.000 15003240 15 Rice, brown 0.050000 1.000 1.000 8F4937 15003241 15 Rice, brown - babyfood 0.050000 1.000 1.000 15003250 15 Rice, flour 0.050000 1.000 1.000 8F4937 15003251 15 Rice, flour - babyfood 0.050000 1.000 1.000Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 12 of 14 15003260 15 Rice, bran 0.050000 1.000 1.000 8F4937 15003261 15 Rice, bran - babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 3F4193 26003420 M Sheep, kidney 0.100000 1.000 1.000 26003430 M Sheep, liver 0.100000 1.000 1.000 15003440 15 Sorghum, grain 0.050000 1.000 1.000 15003450 15 Sorghum, syrup 0 .050000 1.000 1.000 06003470 6 Soybean, seed 0.050000 1.000 1.000 8F7424 06003480 6 Soybean, flour 0.050000 1.000 1.000 06003481 6 Soybean, flour - babyfood 0.050000 1.000 1.000 06003490 6 Soybean, soy milk 0.050000 1.000 1.000 06003491 6 Soybean, soy milk - babyfood or in 0.050000 1.000 1.000 06003500 6 Soybean, oil 0.050000 1.000 1.000 8F7424 06003501 6 Soybean, oil - babyfood 0.050000 1.000 1.000 09023560 9B Squash, summer 0.500000 1.000 1.000 0E6085 09023561 9B Squash, summer - babyfood 0.500000 1.000 1.000 09023570 9B Squash, winter 0.500000 1.000 1.000 0E6085 09023571 9B Squash, winter - babyfood 0.500000 1.000 1.000 95003620 O Sugarcane, sugar 0.050000 1.000 1.000 6F4661 9500 3621 O Sugarcane, sugar - babyfood 0.050000 1.000 1.000 95003630 O Sugarcane, molasses 0.050000 1.000 1.000 6F4661 95003631 O Sugarcane, molasses - babyfood 0.050000 1.000 1.000 01033660 1CD Sweet potato 0.050000 1.000 1.000 9E7577 01033661 1CD Sweet potato - babyfood 0.050000 1.000 1.000 9E7577 01033710 1CD Tanier, corm 0.050000 1.000 1.000 9E7577 08003740 8 Tomatillo 0.050000 1.000 1.000 0F6169 08003750 8 Tomato 0.050000 1.000 1.000 0F6169 08003751 8 Tomato - babyfood 0.050000 1.000 1.000 08003760 8 To mato, paste 0.050000 1.000 1.000 0F6169 08003761 8 Tomato, paste - babyfood 0.050000 1.000 1.000 08003770 8 Tomato, puree 0.050000 1.000 1.000 0F6169 08003771 8 Tomato , puree - babyfood 0.050000 1.000 1.000 08003780 8 Tomato, dried 0.050000 14.300 1.000 0F6169 08003781 8 Tomato, dried - babyfood 0.050000 14.300 1.000 08003790 8 Tomato, juice 0.050000 1.500 1.000 0F6169 01033870 1CD Turmeric 0.050000 1.000 1.000 9E7577 14003910 14 Walnut 0.050000 1.000 1.000 8F4937 86010000 O Water, direct, all sources 0.059200 1.000 1.000 DP#358 Full comment: DP#358032 86020000 O Water, indirect, all sources 0.059200 1.000 1.000 09013990 9A Watermelon 0.100000 1.000 1.000 09014000 9A Watermelon, juice 0.100000 1.000 1.000 15004050 15 Wild rice 0.050000 1.000 1.000 8F4937 01034060 1CD Yam, true 0.050000 1.000 1.000 9E7577 01034070 1CD Ya m bean 0.050000 1.000 1.000 9E7577Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 13 of 14 Attachment 2: Acute Results File U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Analysis for HALOSULFURON - METHYL (1994 - 98 data) Resi due file: acute & chronic 128721.R98 Adjustment factor #2 NOT used. Analysis Date: 02 - 17 - 2010/13:47:27 Residue file dated: 02 - 17 - 2010/13:45:22/8 NOEL (Acute) = 50.000000 mg/kg body - wt/day Daily totals for food and foodform consumption used. Ru n Comment: "Acute is only for Females 13 - 49 yrs"

=============================================================================== Summary calculations (per capita): 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Females 13 - 49 yrs: 0.003401 0.68 14702 0.005484 1.10 9116 0.008568 1.71 58 35Halosul furon - methyl Dietary Exposure and Risk Assessment DP Number: 367059

PC Code: 128721

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Page 14 of 14 U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for HALOSULFURON - METHYL (1994 - 98 data) Residue file name: C: \ Documents and Settings \ drate \ Desktop \ Halosulfuron \ DEEM \ acute & chron ic 128721.R98 Adjustment factor #2 NOT used. Analysis Date 02 - 17 - 2010/13:46:02 Residue file dated: 02 - 17 - 2010/13:45:22/8 Reference dose (RfD, Chronic) = .1 mg/kg bw/day NOEL (Chronic) = 10 mg/kg bw/day C OMMENT 1: Acute is only for Females 13 - 49 yrs

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------ ------- Total Exposure

----------------------------------- Population mg/kg Margin of Percent Subgroup body wt/day Exposure 1/ of RfD

-------------------------------------- ------------- ---------- --------- U.S. Population (total) 0.001705 5,865 1.7% U.S. Population (spring season) 0.0 01697 5,892 1.7% U.S. Population (summer season) 0.001855 5,390 1.9% U.S. Population (autumn season) 0.001643 6,086 1.6% U.S. Population (winter season) 0.001620 6,171 1.6% Northeast region 0.001596 6,267 1.6% Midwest region 0.001723 5,805 1.7% Southern region 0.001621 6,168 1.6% Western regi on 0.001917 5,216 1.9% Hispanics 0.001924 5,198 1.9% Non - hispanic whites 0.001664 6,010 1.7% Non - hispanic blacks 0.001612 6,204 1.6% Non - hisp/non - white/non - black 0.002126 4,704 2.1% All infants (< 1 year) 0.005059 1,977 5.1% Nursing infants 0.002081 4,806 2.1% Non - nursing infants 0.006189 1,616 6.2% Children 1 - 6 yrs 0.002864 3,491 2.9% Children 7 - 12 yrs 0.001761 5,677 1.8 % Females 13 - 19 (not preg or nursing) 0.001258 7,948 1.3% Females 20+ (not preg or nursing) 0.001577 6,341 1.6% Females 13 - 50 yrs 0.001578 6,338 1.6% Females 13+ (preg/n ot nursing) 0.001599 6,252 1.6% Females 13+ (nursing) 0.002110 4,740 2.1% Males 13 - 19 yrs 0.001387 7,209 1.4% Males 20+ yrs 0.001467 6,815 1.5% Seniors 55+ 0.001560 6,411 1.6% Children 1 - 2 yrs 0.003157 3,167 3.2% Children 3 - 5 yrs 0.002823 3 ,542 2.8% Children 6 - 12 yrs 0.001859 5,380 1.9% Youth 13 - 19 yrs 0.001327 7,537 1.3% Adults 20 - 49 yrs 0.001511 6,618 1.5% Adults 50+ yrs 0.001558 6,420 1.6% Females 13 - 49 yrs 0.001503 6,655 1.5%

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