[Federal Register Volume 88, Number 236 (Monday, December 11, 2023)]
[Notices]
[Page 85894]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2023-27113]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The invention listed below is owned by an agency of the U.S. 
Government and is available for licensing to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Theodoric Mattes at 240-627-3827, or 
<a href="/cdn-cgi/l/email-protection#087c606d676c677a616b2665697c7c6d7b48666160266f677e"><span class="__cf_email__" data-cfemail="0f7b676a606b607d666c21626e7b7b6a7c4f61666721686079">[email protected]</span></a>. Licensing information may be obtained by 
communicating with the Technology Transfer and Intellectual Property 
Office, National Institute of Allergy and Infectious Diseases, 5601 
Fishers Lane, Rockville, MD 20852; tel. 301-496-2644. A signed 
Confidential Disclosure Agreement will be required to receive copies of 
unpublished information related to the invention.

SUPPLEMENTARY INFORMATION: Technology description follows:

Vaccine for Cats To Block Toxoplasma Gondii Oocyst Shedding and 
Transmission

    Description of Technology:
    Toxoplasma gondii is the zoonotic causative agent of toxoplasmosis, 
a disease of significant concern for pregnant persons and livestock. A 
member of the phylum Apicomplexa, Toxoplasma gondii can infect almost 
any cell type found in mammals and birds. There are multiple 
transmission pathways, including consumption of undercooked meat from 
infected animals, consumption of unwashed plants, contaminated water 
supplies, blood transfers, and congenital transfer. Felines are 
considered the definitive host of Toxoplasma gondii. Direct or indirect 
transmission can occur via contact with the stool of infected felines.
    Researchers at the National Institute of Allergy and Infectious 
Diseases (NIAID), the U.S. Department of Agriculture (USDA), and the 
University of South Bohemia ([Ccaron]esk[eacute] Bud[ecaron]jovice, 
Czechia) have demonstrated that T. gondii strains lacking expression of 
either the intracellular transport protein IFT88 or the CYS-6-type 
surface antigen SRS15B prevent the formation of oocysts and have 
potential for broad immunity to T. gondii. The inventors propose that 
mass inoculation of felines, specifically wild or feral felines, with a 
live vaccine developed from these strains could result in a significant 
reduction in oocyst production and environment contamination, reducing 
further infection in a geographical area. It is also proposed that loss 
of IFT88 or SRS15B homologs in other Apicomplexa parasites, like 
Neospora, Sarcocystis, or Cryptosporidium could have a similar impact.
    This technology is available for licensing for commercial 
development in accordance with 35 U.S.C. 209 and 37 CFR part 404, as 
well as for further development and evaluation under a research 
collaboration.
    Potential Commercial Applications:

<bullet> Live vaccine for felines against Toxoplasma gondii infection
<bullet> Reduction in environmental Toxoplasma gondii oocysts

    Competitive Advantages:

<bullet> 100% blocked Toxoplasma gondii oocyst shedding in felines
<bullet> Detectable seroconversion protective against future Toxoplasma 
gondii infection
<bullet> Scalable production strain with predictable inactivation of 
IFT88 or SRS15B gene
<bullet> Materials available for development or licensing

    Development Stage:

<bullet> Pre-Clinical

    Inventors: Michael Grigg (NIAID), Aline Sardinha da Silva (NIAID), 
Viviana Pszenny (NIAID), Jitender Dubey (USDA), and Julius Luke[scaron] 
(University of South Bohemia, Czechia).
    Intellectual Property: HHS Reference No. E-118-2023-2. U.S. 
Provisional Patent Application No. 63/470,773 filed June 4, 2023.
    Licensing Contact: To license this technology, please contact 
Theodoric Mattes at 240-627-3827, or <a href="/cdn-cgi/l/email-protection#a9ddc1ccc6cdc6dbc0ca87c4c8ddddccdae9c7c0c187cec6df"><span class="__cf_email__" data-cfemail="abdfc3cec4cfc4d9c2c885c6cadfdfced8ebc5c2c385ccc4dd">[email protected]</span></a>., and 
reference E-118-2023-2.
    Collaborative Research Opportunity: The National Institute of 
Allergy and Infectious Diseases is seeking statements of capability or 
interest from parties interested in collaborative research to further 
develop, evaluate, or commercialize this technology. For collaboration 
opportunities, please contact Theodoric Mattes at 240-627-3827, or 
<a href="/cdn-cgi/l/email-protection#e99d818c868d869b808ac784889d9d8c9aa9878081c78e869f"><span class="__cf_email__" data-cfemail="295d414c464d465b404a0744485d5d4c5a69474041074e465f">[email protected]</span></a>.

     Dated: December 5, 2023.
Surekha Vathyam,
Deputy Director, Technology Transfer and Intellectual Property Office, 
National Institute of Allergy and Infectious Diseases.
[FR Doc. 2023-27113 Filed 12-8-23; 8:45 am]
BILLING CODE 4140-01-P


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