# Support Documents for

Significant New Use Rules (SNURs) on

Premanufacture Notices (PMNs)

P-09-589 and P-09-590

EPA Docket EPA-HQ-OPPT-2010-1075

# Index

A-001 Structure Activity Team (SAT) Report s for

PMNs P -09-589 and P -09-590

A-002 Initial Review Engineering Reports for

PMNs P-09- 589 and P -09-590

A-003 Init ial Review Exposure Reports for

PMNs P-09- 589 and P -09-590

# A-001

Structure Activity Team (SAT) Reports

for PMNs P-09-589 and P-09-590

## SAT Report

PMN Number: P-09-0589

SAT Date: 9/1/2009

Related cases : Health related cases:

Ecotox related cases:

Concern levels :



### Type of Concern: Health Eco Comments

Level of Concern: 2-3 3 Health: PMN ; Eco:

2-3 Health: Hydrol Pdt ; Eco:

Persistence Bioaccum Toxicity Comments

1 1 3 PMN substance

2 1 3

Exposure Based Review :
Health: N o
Ecotox: N o

Routes of exposure : Health: Dermal Drinking Water Inhalation

Ecotox: All releases to water

Fate: ; PMN negl; Hyd Pdt apid; Hyd Pdt rapid

P 2 Rec Comments : Comment: N o Commen t

Keywords : Keywords: IRR/CORR-E,S,L,MM

ACUTE

REPRO

MUTA

ONCO

BLOOD

SENS-S SYSTOX: SPLEEN, LIVER, BONE

KIDNEY

N EURO (CNS)

DEVEL

### AQUATOX-A,C

Summary of Assessment :

Fate : Fate Summary: P-09-0589 FATE: Estimations for hydrolysis product MW 87 log Kow = 0.63 (M) log Koc = 2.06 (E) log Fish BCF = 0.50 (E) log Fish BAF = 0.074 (E) FATE: Estimations for hydrolysis product MW 104 log Kow = -0.05 (E) log Koc = 1.94 (E) log Fish BCF = 0.50 (E) log Fish BAF = -0.019 (E) PMN Substance: Liquid with MP = -40 EC (M)

S = Reacts Hydrolysis Half-life = min - hr

VP = 1.1E-2 torr at 25 EC (E) BP = 266 EC (E) H < 1.00E-8 (E) POTW removal (%) = via hydrolysis; then Hyd Pdt 15 via biodeg; Hyd Pdt 0. Time for complete ultimate aerobic biodeg = Hyd Pdt Hyd Pdt mo Sorption to soils/sediments = Hyt Pdt low; Hyd Pdt low. PBT Potential: PMN P1B1; Hyd Pdt P2B1; Hyd Pdt P2B1. *CEB FATE: Migration to ground water = PMN negl;Hyd Pdt rapid; Hyd Pdt rapid.

Health : Health Summary: Absorbed with reaction all routes, based on

p hysical/chemical properties. There are concerns for; irritation/corrosion to all exposed tissues; dermal sensitization; acute toxicity; systemic effects to the spleen, liver, and bone marrow; kidney toxicity; neurotoxicity (i.e., effects to the central nervous system); reproductive toxicity; blood toxicity; mutagenicity; oncogenicity; and developmental toxicity, based on test data for analogs.

Test Data: Submitted with the PMN the major component

N egative in the Ames assay, with and without activation;

N egative for chromosome abberation in CHO cells, with and without activation; Rat acute oral toxicity LD50 2.52 g/kg; Moderate eye irritant (species unspecified); Slight skin irritant in rabbits; Rat repeated dose (28D) oral reproductive toxicity NOAEL 250 mg/kg;

### Rat repeated dose (28D) oral toxicity NOAEL 10 mg/kg, with effects to the blood, spleen, liver,

and bone marrow

Submitted with

Moderate skin irritant in rabbits; Moderate to severe eye irritant in rabbits; Adverse acute effects to the blood, bone marrow, spleen, and nervous system in rats (single oral dose 1.46 g/kg, 15-day study); Moderate dermal sensitizer in female guinea pigs (4/15 showed positive reaction); Dermal irritant in guinea pigs;

Submitted with :

Ames assay negative with and without activation; Chromosome aberration in human peripheral blood lymphocytes negative with and without activation;

N ot a skin sensitizer in male guinea pigs; Rat repeated dose (28D) oral(gavage) toxicity NOAEL 15 mg/kg, with reversible effects to the blood, spleen, liver, and kidney

Submitted with :

Moderate skin irritant in rabbits; Adverse acute effects to the blood, bone marrow, spleen, and nervous system in rats (single oral dose 1.46 g/kg, 15-day study), acute oral (gavage) LD50 > 1.46 g/kg;

N ot a dermal sensitizer in female guinea pigs (4/15 showed equivocal response)

Submitted with (most data for ):

Ames assay negative with and without activation; Chromosome aberration in human peripheral blood lymphocytes negative with activation and

p ositive without activation (at highest dose, at 44 hrs); Corrosive to rabbit eyes; Mild skin irritant in rabbits; Skin sensitizer in guinea pigs (M&K); equivocal in Buehler test; Rat acute oral LD50 2.3 g/kg; Mouse acute oral LD50 1.0 g/kg; Repeated dose oral (gavage) toxicity LOEL 10-25 mg/kg, with effects to the blood, spleen, liver, and kidney; Rat acute neurotoxicity LOEL 300 mg/kg, with NOEL 100 mg/kg; Rat subchronic (13 wk) neurotoxicity LOEL 400 mg/kg, with NOEL 124 mg/kg; Rat oral (gavage) developmental toxicity NOAEL 600 mg/kg (highest dose tested), with no maternal toxicity NOAEL; Rabbit oral (gavage) developmental toxicity LOAEL 24 mg/kg, with NOAEL 14 mg/kg, and with no maternal toxicity NOAEL ;

### Rat two-generation oral (gavage) reproductive toxicity LOAEL 10 mg/kg (lowest dose tested);

Induces liver tumors

Submitted with :

Ames assay negative with and without activation; Sister chromatid exchange in CHO cells positive with activation (weak response), negative without activation; Severe eye irritant (species not specified); Corrosive to rabbit skin; Extreme skin sensitizer in guinea pigs; Rat acute oral LD50 2.0-3.0 g/kg; Rabbit acute dermal LD50 0.5-2.0 g/kg; Rat (M) oral (gavage) reproductive toxicity LOAEL 186 mg/kg (single dose)

Ecotox :

Test Organism Test Type Test End

Point Predicted Measured Comments

fish 96-h LC50 33
daphnid 48-h LC50 3.1
green algal 96-h EC50 1.2

fish chronic value 0.55
daphnid

_ chronic value 0.015
algal

_ chronic value 0.52
Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value

_

Ecotox Values Comments: Predictions are based on SARs for for the hydrolysis products; SAR chemical class = (hydrolysis product); MW 242; liquid (P); log Kow = 1.69 (EPI, hydrolysis product); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern ( p pb) 2

SARs

SAR Class

Ecotox Factors Comments:

SAT Chair: J. Kwiat

## SAT Report

PMN Number: P-09-0590

SAT Date: 9/1/2009

Related cases : Health related cases:

Ecotox related cases:

Concern levels :



### Type of Concern: Health Eco Comments

Level of Concern: 2-3 3 Health: PMN ; Eco:

2-3 Health: Hydrol Pdt ; Eco:

Persistence Bioaccum Toxicity Comments

1 1 3 PMN substance

2 1 3

Exposure Based Review :
Health: N o
Ecotox: N o

Routes of exposure : Health: Dermal Drinking Water Inhalation

Ecotox: All releases to water

Fate: ; PMN negl; Hyd Pdt rapid; Hyd Pdt rapid

P 2 Rec Comments : Comment: N o Commen t

Keywords : Keywords: IRR/CORR-E,S,L,MM

ACUTE

REPRO

ONCO

BLOOD

SENS-S SYSTOX: SPLEEN, LIVER, BONE

KIDNEY

N EURO (CNS)

DEVEL AQUATOX-A,C

### Summary of Assessment :

Fate : Fate Summary: P-09-0590 FATE: Estimations for hydrolysis product MW 87 log Kow = 0.63 (M) log Koc = 2.06 (E) log Fish BCF = 0.50 (E) log Fish BAF = 0.074 (E) FATE: Estimations for hydrolysis product MW 92 log Kow = -0.41 (E) log Koc = 1.64 (E) log Fish BCF = 0.50 (E) log Fish BAF = -0.037 (E) PMN Substance: Liquid with MP < -25 EC (M)

S = Reacts Hydrolysis Half-life = min - hr

VP = 0.17 torr at 25 EC ( N OMO5) BP = 213 EC ( N OMO5) based on 59 EC @ 1.5 mm Hg (M) H < 1.00E-8 (E) POTW removal (%) = via hydrolysis; then Hyd Pdt 15 via biodeg; Hyd Pdt 0. Time for complete ultimate aerobic biodeg = Hyd Pdt mo; Hyd Pdt mo Sorption to soils/sediments = Hyt Pdt low; Hyd Pdt low. PBT Potential: PMN P1B1; Hyd Pdt P2B1; Hyd Pdt P2B1. *CEB FATE: Migration to ground water = PMN negl;Hyd Pdt rapid; Hyd Pdt rapid.

Health : Health Summary: Absorbed with reaction all routes, based on physical/chemical properties. There are concerns for; irritation/corrosion to all exposed tissues; dermal sensitization; acute toxicity; systemic effects to the spleen, liver, and bone marrow; kidney toxicity; neurotoxicity (i.e., effects to the central nervous system); reproductive toxicity; blood toxicity; oncogenicity; and developmental toxicity, based on test data for analogs.

Test Data: Submitted with the PMN (analog data, the major component ):

N egative in the Ames assay, with and without activation;

N egative for chromosome abberation in CHO cells, with and without activation; Rat acute oral toxicity LD50 2.52 g/kg; Moderate eye irritant (species unspecified); Slight skin irritant in rabbits; Rat repeated dose (28D) oral reproductive toxicity NOAEL 250 mg/kg; Rat repeated dose (28D) oral toxicity NOAEL 10 mg/kg, with effects to the blood, spleen, liver,

and bone marrow

### Submitted with (most data for ):

Ames assay negative with and without activation; Chromosome aberration in human peripheral blood lymphocytes negative with activation and

p ositive without activation (at highest dose, at 44 hrs); Corrosive to rabbit eyes; Mild skin irritant in rabbits; Skin sensitizer in guinea pigs (M&K); equivocal in Buehler test; Rat acute oral LD50 2.3 g/kg; Mouse acute oral LD50 1.0 g/kg; Repeated dose oral (gavage) toxicity LOEL 10-25 mg/kg, with effects to the blood, spleen, liver, and kidney; Rat acute neurotoxicity LOEL 300 mg/kg, with NOEL 100 mg/kg; Rat subchronic (13 wk) neurotoxicity LOEL 400 mg/kg, with NOEL 124 mg/kg; Rat oral (gavage) developmental toxicity NOAEL 600 mg/kg (highest dose tested), with no maternal toxicity NOAEL; Rabbit oral (gavage) developmental toxicity LOAEL 24 mg/kg, with NOAEL 14 mg/kg, and with no maternal toxicity NOAEL ; Rat two-generation oral (gavage) reproductive toxicity LOAEL 10 mg/kg (lowest dose tested);

Induces liver tumors

Submitted with :

Ames assay negative with and without activation; Sister chromatid exchange in CHO cells positive with activation (weak response), negative without activation; Severe eye irritant (species not specified); Corrosive to rabbit skin; Extreme skin sensitizer in guinea pigs; Rat acute oral LD50 2.0-3.0 g/kg; Rabbit acute dermal LD50 0.5-2.0 g/kg; Rat (M) oral (gavage) reproductive toxicity LOAEL 186 mg/kg (single dose)

Ecotox :

Test Organism Test Type Test End

Point Predicted Measured Comments

fish 96-h LC50 31
daphnid 48-h LC50 2.9
green algal 96-h EC50 1.1

fish

_ chronic value 0.52
daphnid chronic value 0.015
algal

_ chronic value 0.49
Sewage Sludge 3-h EC50

_

### Sewage Sludge

_ Chronic Value

_

Ecotox Values Comments: Predictions are based on SARs for for the hydrolysis products; SAR chemical class = (hydrolysis product); MW 230; liquid (P); log Kow = 1.69 (EPI, hydrolysis product); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern ( p pb) 2

SARs

SAR Class

Ecotox Factors Comments:

SAT Chair: J. Kwiat

# A-002

Initial Review Engineering Reports

for PMNs P-09-589 and P-09-590

### INITIAL REVIEW ENGINEERING REPORT

P-09-0589 Focus Ready Draft 9/14/2009

ENGINEER: El-Zoobi \ AG PV (kg/yr):

Revision Notes/Assessment Overview:

SUBMITTER:

Consumer Use:

SAT (concerns): (9/1/2009):

Related Cases and Misc SAT Info:

Migration to groundwater: PBT rating: P 2 B 1 T 3 PMN: Health 2-3; Eco 3 // Hydrolysis Product: Health 2-3 /// PMN: P1B1T3 //

: P2B1T3

Health: 2-3, Dermal , Drinking Water , Inhalation

Eco: 3, Water (All releases to water with a CC = 2 ppb)

OCCUPATIONAL EXPOSURE RATING: 2B

NOTES & KEY ASSUMPTIONS:Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS:

P2 REC:

EXPOSURE-BASED REVIEW:P-09-0589P-09-0589

### INITIAL REVIEW ENGINEERING REPORT

P-09-0590 Focus Ready Draft 9/14/2009

ENGINEER: El-Zoobi \ AG PV (kg/yr):

Revision Notes/Assessment Overview:

SUBMITTER:

USE:

Consumer Use: N o

SAT (concerns): (9/1/2009):

Related Cases and Misc SAT Info:

Migration to groundwater: PBT rating: P 2 B 1 T 3 PMN: Health 2-3; Eco 3 // Hydrolysis Product: Health 2-3 /// PMN: P1B1T3 //

: P2B1T3

Health: 2-3, Dermal, Drinking Water, Inhalation

Eco: 3, Water (All releases to water with a CC = 2 ppb)

OCCUPATIONAL EXPOSURE RATING: 2-3BNOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS:

P2 REC:

EXPOSURE-BASED REVIEW:P-09-0590P-09-0590

### STANDARD REVIEW ENGINEERING REPORT

P-09-0589

Standard Review Draft 11/10/2009

ENGINEER: El-Zoobi \ AG PV (kg/yr):

SUBMITTER:

USE:

SAT (concerns): (9/1/2009 ):

Related Cases and Misc SAT Info:

Migration to groundwater: PBT rating: P 2 B 1 T 3 PMN: Health 2-3; Eco 3 // Hydrolysis Product: Health 2-3 /// PMN: P1B1T3 //: P2B1T3

Health: 2-3, Dermal, Drinking Water , Inhalation

Eco: 3, Water (All releases to water with a CC = 2 ppb)

OCCUPATIONAL EXPOSURE RATING: 1-2B

NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS:

P2 REC:

EXPOSURE-BASED REVIEW: N oP-09-0589P-09-0589

### STANDARD REVIEW ENGINEERING REPORT

P-09-0590

Standard Review Draft 11/25/2009

ENGINEER: El-Zoobi \ AG PV (kg/yr):

SUBMITTER:

USE:

Consumer Use:

SAT (concerns): (9/1/2009):

Related Cases and Misc SAT Info:

Migration to groundwater: Other (please specify)PBT rating: P 2 B 1 T 3 PMN: Health 2-3; Eco 3 // Hydrolysis Product: Health 2-3 /// PMN: P1B1T3 //

: P2B1T3

Health: 2-3, Dermal, Drinking Water, Inhalation

Eco: 3, Water (All releases to water with a CC = 2 ppb)

OCCUPATIONAL EXPOSURE RATING: 2B

NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.P-09-0590P-09-0590

# A-003

Initial Review Exposure Reports

for PMNs P-09-589 and P-09-590September 11, 2009 page of

INITIAL REVIEW EXPOSU RE REPORT (IRExR)

Chemical ID: P090590 Reviewer: Sherer

Results Table: Dose, Concentration, and Days Exceeded Results Summary

Exposure Scenario 1 Water Landfill Stack Air Fugitive Air Drinking Water Fish Ingestion

ADR LADD ADR LADD 7Q10 4

CC=2 PDM Days

Exceeded LADD ADR LADD ADR LADD Release activity(ies) 2 ;

exposure calculation(s) 3

mg/kg/day mg/kg/day mg/kg/day mg/kg/day μ g/l # Days mg/kg/day mg/kg/day mg/kg/day mg/kg/day mg/kg/day

max LADD --- --- --- --- --- --- 1.79e-04

--- --- --- ---

max ADR, max Acute Eco, PDM, max

LADD 5.17e-03 2 31e-05 6.13e -05 3.13e-07 113.21 85

--- --- --- --- ---

1 Exposure scenario titles consist of release activ ity followed by exposure calculation abbreviation.

2 Release activities are from engineering report's Manufactur ing (Mfg), Processing (Proc) and Use release activity

labels. Multiple release activities are combined in one exposure scenario if their releases occur at same location.

3 Exposure calculations are Acute Dose Rate (ADR), Lifetime Average Daily Dose (LADD), and Probabilistic Dilution Model (PDM). There may be one, two, or all three exposure calculations per exposure scenario. CC is the aquatic concentration of concern.

4 This column displays concentration values for the 7Q10 streamflow, which is defined as the average streamflow of the 7 consecutive days of lowest flow within a 10 year period.

Remarks:

Fate test recommendations?: (default is NA)September 11, 2009 page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P090590 Assessor: Sherer

ENVIRONMENTAL RELEASES

Scenario#:1 Number of Release Sites:

Release Activity: max LADD

Release Description: WATER LANDFILL

Non-sludge/Sludge STACK FUGITIVE

Total Releases:

(kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge

Release Days/yr:

Per Site Release:

(kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:September 11, 2009 page of

INITIAL EXPOSURE REVIEW REPORT

Chemical ID: P090590

DRINKING WATER EXPOSURE ESTIMATES FROM LANDFILL RELEASES

SCENARIO #: 1 ACTIVITY: - max LADD

RELEASE DESCRIPTION:

EXPOSED POPULATION: Adult

NUMBER

OF

SITES NON-SLUDGE

LANDFILL

RELEASE AND

DAYS OF

RELEASE (kg/site/day)/(days) LANDFILLED

SLUDGE 1

AND DAYS OF

RELEASE
(kg/site/day)/(days) MIGRATION

DESCRIPTOR 2 ADSORPTION

TO

WASTEWATER

SLUDGE (%) DRINKING

WATER

TREATMENT (%)

1 Landfilled sludge equals the fraction adsorbed to wastewater treatment sludge times the surface water pre-treatment release.

2 Migration Descriptor Log Koc Groundwater Concentration (GWC) (mg/L per kg release) Negligible no migration None Negligible to slow > 4.5 3.21E-6

Slow <4.5 to 3.5 2.67E-5

Moderate <3.5 to 2.5 5.95E-5 Rapid <2.5 7.55E-5

ASSUMPTIONS Exposure Units Results ED (years) AT (years) BW (kg) IR (L/day)

Cancer

LADD pot (mg/kg/day) 1.79E-04 30.00 75.00 71.80 1.40

LADC pot (mg/L) 9.18E-03 30.00 75.00 NA NA

REMARKS:September 11, 2009 page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P090590 Assessor:

ENVIRONMENTAL RELEASES

Scenario#:2 Number of Release Sites:

Release Activity: - max ADR, max acute eco, PDM, max LADD

Release Description: WATER LANDFILL

Non-sludge/Sludge STACK FUGITIVE

Total Releases:

(kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge

Release Days/yr:

Per Site Release:

(kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:September 11, 2009 page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090590

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 2 Number of Sites: RELEASE ACTIVITY max
ADR, max acute eco, PDM, max

LADD

SIC-CODE DESCRIPTION: POTW's (All facilities)

SIC-CODE (S): 4952 EX POSED POPULATION: Adult

WWT

REMOVAL (%) RELEASE

DAYS PRETREATMENT

RELEASE (kg/site/day) POSTTREATMENT

RELEASE (kg/site/day) DWT

(%) BCF (L/kg)

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER

PLANT

TYPE % ILE

FACILITY STREAM FLOW (MLD) STREAM CONC. ( μ g/l)

Harmonic

Mean 30Q5 7Q10 1Q10 Harmonic

Mean 30Q5 7Q10 1Q10

ALL 50 125.56 44.02 26.80 22.53 0.96 2.73 4.48 5.33

ALL 10 11.11 1.94 1.06 0.96 10.80 61.86 113.21 125.00

DRINKING WATER AND FISH IN GESTION EXPOSURE ESTIMATES

Exposure Units Drinking Water Results Drinking

Water Units Fish Ingestion Results Fish Ingestion

Units

50% 10% 50% 10%

Cancer

LADD pot 2.04E-06 2.31E-05 mg/kg/day 2.77E-08 3.13E-07 mg/kg/day

LADC pot 1.05E-04 1.18E-03 mg/L 3.31E-04 3.74E-03 mg/kg

Acute

ADR pot 2.28E-04 5.17E-03 mg/kg/day 5.43E-06 6.13E-05 mg/kg/day

SIC Code Comments:September 11, 2009 page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090590

SIC CODE EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 2 RELEASE ACTIVITY: max ADR, max acute eco, PDM, max

LADD

SIC CODE DESCRI PTION: POTW's (All facilities)

ASSOCIATED SIC CODES: 4952

SIC CODE RESULTS

COC ( μ g/L) Percent of

Year COC

Exceeded Number of Days COC

Exceeded Release days/year Loading (kg/site/day) Waste Water Treatment (%) High/Avg Analysis

2.00 23 85 High

Remark: COC is exceeded more than 20 days/year.September 11, 2009 page of



## LEGEND FOR NEW CHEMICAL S EXPOSURE REPORT

This new chemicals exposure report wa s prepared by the Exposure Assessment Branch (EAB) of the Economics, Exposure and Technology Division, Office of Pollution Prevention and Toxics, USEPA.

The goals of these reports are to calcula te conservative (protective) estimates of exposure endpoints for consumers, the general population, and the environment.

For each exposure scenario to industrial releases, the following three endpoints are calculated: (1) maximum possible acute concentrations and doses (2) maximum possible chronic concentrations and doses (3) for water releases ≥ 20 days, the probability of exceedence of the aquatic concentration of concern These endpoints are identified by abbreviati ons on the Release Activity line, e.g., (1) max ADR , (2) max LADD , (3) max PDM . Depending on the release inputs, these e ndpoints may be calculated and presented on the same page or different pages. That is, a release activity ID of mfg; max ADR, max PDM, max LADD indicates that all the exposure endpoints were cal culated from common manufacturing release values; conversely, a release activity ID of mfg &proc; max ADR indicates that only the maximum acute exposure values were calculated for manufacturing and proce ssing releases that occurred at the same site.

For each consumer product use exposure scenario, whether exposure is to the user directly or to the general population/environment, the maximum exposure values are calculated and presented together.

In addition to the exposure values above, EPA policy dir ects that exposure and release values be compared to criteria threshold values for Exposure-based and PBT Exposure-based cases.

Exposure-based (YX) cases (those with ≥ 100,000 kg/yr production volume)

Criteria are exceeded under the following conditions: Presence in consumer product with likely exposure

≥ 3E-3 mg/kg/d exposure via air, fish ingestion or drinking water

≥ 10,000 kg/yr release to environment (post-treatment)

≥ 1,000 kg/yr release to water (post-treatment)

Persistent, Bioaccumulative, Toxic (PBT) chemical s of P2B2 rating or hi gher and production volume ≥ 20,000 kg/yr Criteria are exceeded as for YX cases, with the following differences:

≥ 2,000 kg/yr release to environment (post-treatment)

≥ 200 kg/yr release to water (post-treatment)

Bolding rules in the Report: Values for endpoints above th at are also health or eco concerns are bolded.