Exhibit 4.6





 


Execution Version


 


CIPHER PHARMACEUTICALS INC.


 


and


 


CARDIOME PHARMA CORP.


 


and


 


CORREVIO PHARMA CORP.


 




ARRANGEMENT AGREEMENT


 


March 19, 2018





 




     


     


    

  


TABLE OF
CONTENTS


 





	Article 1 INTERPRETATION	1
	1.1	Definitions	1
	1.2	Interpretation	12
	1.3	Number, Gender and Persons	13
	1.4	Date for Any Action	13
	1.5	Currency	13
	1.6	Accounting Matters	13
	1.7	Knowledge	13
	1.8	Schedules	13
	 	 	 
	Article 2 THE ARRANGEMENT	14
	2.1	Arrangement	14
	2.2	Obligations	14
	2.3	Interim Order	14
	2.4	Cardiome Meeting	15
	2.5	Cardiome Circular	16
	2.6	Final Order	17
	2.7	Court Proceedings	18
	2.8	Articles of Arrangement and Effective Date	18
	2.9	Payment of Consideration	18
	2.10	Announcements and Consultations	19
	2.11	Withholding Taxes	19
	2.12	List of Shareholders	19
	2.13	U.S. Securities Law Matters	19
	2.14	United States Tax Matters	20
	2.15	Canadian Income Tax Matters	20
	2.16	Incentive Plan Matters	21
	2.17	Reorganization	22
	 	 	 
	Article 3 REPRESENTATIONS AND WARRANTIES OF CARDIOME AND CORREVIO	23
	3.1	Representations and Warranties of Cardiome	23
	3.2	Survival of Representations and Warranties of Cardiome	23
	3.3	Representations and Warranties of Correvio	23
	3.4	Survival of Representations and Warranties of Correvio	23
	 	 	 
	Article 4 REPRESENTATIONS AND WARRANTIES OF CIPHER	24
	4.1	Representations and Warranties of Cipher	24
	4.2	Survival of Representations and Warranties of Cipher	24
	 	 	 
	Article 5 COVENANTS	24
	5.1	Covenants of Cardiome Relating to the Arrangement	24
	5.2	Covenants of Cardiome Relating to the Conduct of Business	25
	5.3	Transferred Employees	28
	5.4	Post-Closing Filings	28
	 	 	 
	Article 6 CONDITIONS	28
	6.1	Mutual Conditions Precedent	28
	6.2	Additional Conditions Precedent in Favour of Cipher	30
	6.3	Additional Conditions Precedent in Favour of Cardiome	31
	6.4	Notice and Cure Provisions	31
	6.5	Satisfaction of Conditions	32
	 	 	 
	Article 7 ADDITIONAL COVENANTS	32
	7.1	Covenant Regarding Non-Solicitation	32




 




     


     


    

 


	7.2	Covenant Regarding Acquisition Proposal	32
	7.3	Right to Accept a Superior Proposal	34
	7.4	Access to Information; Confidentiality; Transition	35
	7.5	Insurance and Indemnification	36
	7.6	ROFR on New Canadian Products	36
	7.7	Product Introduction Fee	36
	 	 	 
	Article 8 TERM, TERMINATION, AMENDMENT AND WAIVER	37
	8.1	Term	37
	8.2	Termination	37
	8.3	Expenses	38
	8.4	Termination Payments	38
	8.5	Termination Payment to Cardiome	39
	8.6	Amendment	39
	8.7	Waiver	40
	 	 	 
	Article 9 INDEMNITY AND WARRANTY	40
	9.1	Correvio Indemnity	40
	9.2	Cipher Indemnity	41
	9.3	Taxable Gain Warranty	41
	9.4	Claim Notice	42
	9.5	Agency for Non-Parties	42
	9.6	Procedure for Indemnification – Direct Claims	42
	9.7	Procedure for Indemnification – Third Party Claims	42
	9.8	Cooperation	43
	9.9	Holdback Amount	44
	9.10	Exclusive Remedy	44
	9.11	No Double Recovery	44
	9.12	Price Purchase Consideration Adjustment	45
	 	 	 
	Article 10 GENERAL PROVISIONS AND MISCELLANEOUS	45
	10.1	Privacy	45
	10.2	Notices	45
	10.3	Governing Law	46
	10.4	Injunctive Relief	46
	10.5	Time of Essence	46
	10.6	Entire Agreement, Binding Effect and Assignment	47
	10.7	No Liability	47
	10.8	Severability	47
	10.9	Counterparts, Execution	47




 


SCHEDULES


 


SCHEDULE A 


SCHEDULE B 


SCHEDULE C 


SCHEDULE D 


SCHEDULE E 


SCHEDULE F 


SCHEDULE G 


SCHEDULE H 


SCHEDULE I 


SCHEDULE J 


 




    	 	- 2 -	 



     


    

  


ARRANGEMENT
AGREEMENT


 


Arrangement Agreement dated March 19, 2018
among Cipher Pharmaceuticals Inc. (“Cipher”), Cardiome Pharma Corp. (“Cardiome”) and Correvio
Pharma Corp. (“Correvio”).


 


WHEREAS:


 


A.       Cipher,
Cardiome and Correvio wish to complete a transaction whereby, among other things: (i) all of the outstanding Cardiome Shares (as
hereinafter defined) will be assigned and transferred to Correvio in exchange for Correvio Shares (as hereinafter defined); (ii)
all of the assets and liabilities of Cardiome, other than the Retained Assets and Retained Liabilities (each as hereinafter defined),
will be transferred to and assumed by Correvio; and (iii) Cipher will subsequently acquire all of the outstanding Cardiome Shares
from Correvio;


 


B.       The
Parties intend to carry out the transactions contemplated herein by way of a statutory plan of arrangement, which is to be completed
under the provisions of the CBCA (as hereinafter defined), and on and subject to the terms and conditions contained herein;


 


C.       Cipher
has entered into the Cardiome Voting Agreements (as hereinafter defined) with the Cardiome Supporting Shareholders (as hereinafter
defined), pursuant to which, among other things, such Cardiome Supporting Shareholders agree, subject to the terms and conditions
thereof, to vote the Cardiome Shares and any securities convertible, exercisable or exchangeable into Cardiome Shares held by them
in favour of the Cardiome Arrangement Resolution (as hereinafter defined); and


 


D.       The
Parties have entered into this Agreement to provide for the matters referred to in the foregoing recitals and for other matters
relating to such arrangement.


 


NOW THEREFORE in consideration of
the covenants and agreements herein contained and other good and valuable consideration (the receipt and sufficiency of which are
hereby acknowledged), the Parties hereto covenant and agree as follows:


 


Article
1

INTERPRETATION


 


		1.1	Definitions



 


In this Agreement, unless the context otherwise
requires:


 


“Acquisition Proposal”
means, other than the transactions contemplated by this Agreement, any bona fide offer, proposal or inquiry from any Person
or group of Persons acting jointly or in concert, whether or not in writing and whether or not made public, made after the date
hereof relating to: (a) any acquisition or purchase, direct or indirect, of: (i) all or any part of the assets comprising the Retained
Assets held by Cardiome or any of its subsidiaries, or (ii) 20% or more of the issued and outstanding voting or equity securities
of Cardiome; (b) any take-over bid, tender offer or exchange offer that, if consummated, would result in such Person or group of
Persons beneficially owning 20% or more of the issued and outstanding voting or equity securities of Cardiome; or (c) any plan
of arrangement, merger, amalgamation, consolidation, share exchange, business combination, reorganization, recapitalization, liquidation,
dissolution or other similar transaction involving Cardiome or all or any part of the assets comprising the Retained Assets held
by Cardiome or any of its subsidiaries but not such a transaction affecting solely the Assigned Assets; in all cases, whether in
a single transaction or in a series of related transactions; provided, that, an Acquisition Proposal shall not include any bona
fide offer, proposal or inquiry relating solely to the acquisition of Assigned Assets;


 


“affiliate” has the
meaning ascribed thereto in the Securities Act;


 




     


     


    

  


“Agreement” means this
arrangement agreement, including all schedules annexed hereto, together with the Cardiome Disclosure Letter, as the same may be
amended, supplemented or otherwise modified from time to time, in accordance with the terms hereof;


 


“Ancillary Agreements (Aggrastat)”
means, with respect to the Aggrastat product, collectively (i) a transition services agreement, and (ii) a supply agreement, in
each case to be entered into between Correvio (and any affiliates of Correvio to the extent necessary or advisable) and Cardiome,
containing terms and conditions consistent with the term sheets relating thereto as agreed to by the Parties as of the date hereof,
together with such other terms and conditions as are typical for agreements of such nature and as may otherwise be agreed to by
the Parties, each acting reasonably;


 


“Ancillary Agreements (Brinavess)”
means, with respect to the Brinavess product, collectively (i) a transition services agreement, and (ii) a supply agreement, in
each case to be entered into between Correvio (and any affiliates of Correvio to the extent necessary or advisable) and Cardiome,
containing terms and conditions consistent with the term sheets relating thereto as agreed to by the Parties as of the date hereof,
together with such other terms and conditions as are typical for agreements of such nature and as may otherwise be agreed to by
the Parties, each acting reasonably;


 


“Arrangement” means
the arrangement of Cardiome under Section 192 of the CBCA on the terms and subject to the conditions set out in the Plan of Arrangement,
subject to any amendments or variations to the Plan of Arrangement made in accordance with the terms of this Agreement or Article
7 of the Plan of Arrangement or made at the direction of the Court in the Final Order with the consent of the Parties, each acting
reasonably;


 


“Articles of Arrangement”
means the articles of arrangement of Cardiome in respect of the Arrangement required by the CBCA to be filed with the Director
after the Final Order is made, which shall be in form and content satisfactory to the Parties, each acting reasonably;


 


“Assigned Assets” means
all of the assets, properties, interests and rights of Cardiome and its subsidiaries (of any nature or kind whatsoever), other
than the Retained Assets;


 


“Assignment and Assumption Agreement”
means the assignment and assumption agreement to be entered into on the Effective Date between Cardiome and Correvio, evidencing
the assignment to and the assumption by Correvio of all of the Assumed Liabilities;


 


“Assumed Liabilities”
means all of the Liabilities of Cardiome and its subsidiaries, other than the Retained Liabilities, whether arising before, as
of, or after the Effective Time;


 


“Authorization” means
any authorization, order, Permit, approval, grant, licence, registration, consent, right, notification, condition, franchise, privilege,
certificate, judgment, writ, injunction, award, determination, direction, decision, decree, bylaw, rule or regulation, whether
or not having the force of Law, and includes any Environmental Permit;


 


“Books and Records”
means all information in any form relating to Cardiome (including all predecessor corporations) or the Retained Assets and Retained
Liabilities, including books of account, financial, tax, business, marketing, personnel and research information and records, equipment
logs, operating guides and manuals and all other documents, files, correspondence and other information;


 


“Brinavess Assets” means
all patents, trademarks and goodwill owned by Cardiome related to the Brinavess product and the royalty agreement between Correvio
International Sarl and Cardiome with respect to royalties on non-Canadian Brinavess, but not including any Canadian patents, trademarks
and goodwill related to the Brinavess product;


 


“Business Day” means
any day of the year, other than a Saturday, Sunday or any statutory holiday in Toronto, Ontario or Vancouver, British Columbia;


 




    	 	- 2 -	 



     


    

  


“Cardiome Annual Financial Statements”
means the audited consolidated financial statements of Cardiome as at, and for the financial years ended, December 31, 2016 and
December 31, 2015, including the notes thereto;


 


“Cardiome Arrangement Resolution”
means the special resolution of the Cardiome Shareholders approving the Arrangement, the Plan of Arrangement and this Arrangement
Agreement to be considered at the Cardiome Meeting, substantially in the form attached as Schedule B;


 


“Cardiome Board” means
the board of directors of Cardiome, as the same is constituted from time to time;


 


“Cardiome Circular”
means the notice of the Cardiome Meeting and accompanying management information circular, including all schedules, appendices
and exhibits thereto and enclosures therewith, to be sent to the Cardiome Shareholders and other securityholders of Cardiome, as
required, in connection with the Cardiome Meeting, as amended, supplemented or otherwise modified from time to time;


 


“Cardiome Disclosure Documents”
means all information, disclosure, forms, reports, schedules, statements, certifications and other documents, including without
limitation all press releases, forms, reports, schedules, financial statements and notes and schedules to such financial statements,
management’s discussion and analysis of financial condition and operations, certifications, annual information forms, management
information circulars, material change reports and other documents required to be publicly disclosed or filed by Cardiome with
Securities Authorities pursuant to applicable Securities Laws, and which are available for review under Cardiome’s SEDAR
profile at www.sedar.com;


 


“Cardiome Disclosure Letter”
means the disclosure letter executed by Cardiome and delivered to Cipher prior to or concurrently with the execution of this Agreement;


 


“Cardiome Financial Advisor”
means Evans & Evans, Inc.;


 


“Cardiome Financial Statements”
means, collectively, the Cardiome Annual Financial Statements and the Cardiome Interim Financial Statements;


 


“Cardiome Interim Financial Statements”
means the unaudited consolidated interim financial statements of Cardiome as at, and for the three and nine months ended, September
30, 2017 and September 30, 2016, including the notes thereto;


 


“Cardiome Material Contracts”
means any Contract to which Cardiome is a party or by which Cardiome is bound pursuant to which Cardiome has any material Liability
or for which there is a reasonable potential for Cardiome to have a material Liability but shall not include any contract terminable
with no additional consideration by Cardiome on 30 days or less notice to the counterparty. Without limiting the foregoing, the
term “Cardiome Material Contact” shall include any:


 


		(a)	Contract concerning or relating to the Retained Assets (including the Intellectual Property Assets)
or Retained Liabilities;



 


		(b)	lease or other Contract concerning or relating to real property leased by Cardiome;



 


		(c)	employment or consulting Contract with any officer, employee or consultant of Cardiome (except
for employment or consulting contracts of indefinite hire or subject to automatic renewal entered into in the ordinary course of
business);



 


		(d)	collective bargaining agreement or other Contract with any labour union;



 




    	 	- 3 -	 



     


    

  


		(e)	profit sharing, bonus, stock option, pension, retirement, disability, stock purchase, medical,
dental, hospitalization, insurance or similar plan or agreement providing benefits to any current or former director, officer,
employee or consultant of Cardiome;



 


		(f)	orders or other Contracts for the purchase of products, supplies, equipment or services which involves
aggregate annual expenditures in excess of $50,000;



 


		(g)	orders or other Contracts for the sale of products, supplies, equipment or services which involves
aggregate annual expenditures in excess of $25,000;



 


		(h)	loan or credit agreement, trust indenture, mortgage, promissory note or other Contract for the
borrowing of money under which Cardiome has any obligations;



 


		(i)	agreement of guarantee, support, assumption or endorsement of, or any other similar commitment
with respect to, the Liabilities of, or any agreement to provide financial assistance of any kind to, any other Person;



 


		(j)	Contract pursuant to which Cardiome has any continuing obligations relating to indemnification
that could reasonably be expected to give rise to a Claim in excess of $25,000;



 


		(k)	commitment for charitable contributions;



 


		(l)	Contract providing for annual capital expenditures in excess of $25,000 in the aggregate;



 


		(m)	Contract for the sale of any assets, other than sales of inventory to customers in the ordinary
course of business;



 


		(n)	Contract pursuant to which Cardiome is a lessor of any machinery, equipment, motor vehicles, office
furniture, fixtures or other personal property which involves aggregate payments in excess of $25,000;



 


		(o)	any non-competition or similar Contract or any agreement that prohibits the ability of Cardiome
to participate in any type of business or to conduct business in any geographic area;



 


		(p)	Contract with any officer, director, employee, consultant, shareholder or any other person not
dealing at arm’s length with Cardiome (within the meaning of the Tax Act), except for employment or consultant contracts;



 


		(q)	Contract containing any “change in control”, “assignment” or other similar
provisions that will be triggered by consummation of the transactions contemplated by this Agreement, including the Arrangement;
or



 


		(r)	other Contract, not described above, under which Cardiome has any Liabilities or potential Liabilities
in excess of $50,000 per annum in the aggregate.



 


“Cardiome Meeting” means
the special meeting of Cardiome Shareholders, including any adjournment or postponement thereof, to be called and held in accordance
with the Interim Order to consider the Cardiome Arrangement Resolution and for any other purpose as may be set out in the Cardiome
Circular and agreed to by Cipher;


 


“Cardiome Option Plan”
means the stock option plan of Cardiome, last
approved by Cardiome Shareholders on June 20, 2017;


 


“Cardiome Options” means,
at any time, options to acquire Cardiome Shares granted under the Cardiome Option Plan which are, at such time, outstanding and
unexercised (whether or not vested);


 




    	 	- 4 -	 



     


    

  


“Cardiome Shareholder Approval”
has the meaning ascribed thereto in Subsection 2.3(c);


 


“Cardiome Shareholders”
means the holders of Cardiome Shares;


 


“Cardiome Shares” means
issued and outstanding common shares in capital of Cardiome;


 


“Cardiome Supporting Shareholders”
means, collectively, those senior officers and directors of Cardiome who have entered into Cardiome Voting Agreements;


 


“Cardiome Termination Fee”
has the meaning ascribed thereto in Subsection 8.5(a);


 


“Cardiome Voting Agreements”
means the voting agreements (including all amendments thereto) between Cipher and the Cardiome Supporting Shareholders setting
forth the terms and conditions upon which they have agreed, among other things, to vote their Cardiome Shares in favour of the
Cardiome Arrangement Resolution;


 


“Cardiome Warrants”
means, at any time, purchase warrants to acquire Cardiome Shares which are, at such time, outstanding and unexercised;


 


“CBCA” means the Canada
Business Corporations Act;


 


“Certificate of Arrangement”
means the certificate of arrangement to be issued by the Director pursuant to subsection 192(7) of the CBCA in respect of the Articles
of Arrangement;


 


“Change in Recommendation”
has the meaning ascribed thereto in Subsection 7.2(a)(iv);


 


“Cipher Board” means
the board of directors of Cipher as the same is constituted from time to time;


 


“Cipher Indemnified Parties”
has the meaning ascribed thereto in Subsection 9.1(a);


 


“Claim” means any demand,
action, cause of action, investigation, inquiry, suit, proceeding, claim, complaint, arbitration, charge, prosecution, assessment
or reassessment, including any appeal or application for review, judgment, arbitration, award, grievance, settlement or compromise;


 


“Claim Notice” has the
meaning ascribed thereto in Section 9.4;


 


“Confidentiality Agreement” means the confidentiality
agreement between the Parties made with effect as of October 23, 2017, as amended on February 1, 2018;


 


“Consideration” means
the consideration to be received by Cardiome Shareholders (other than Dissenting Shareholders) for their Cardiome Shares pursuant
to the Plan of Arrangement, consisting of one (1) Consideration Share for each one (1) Cardiome Share in accordance with the Exchange
Ratio (subject to any adjustment of the Exchange Ratio);


 


“Consideration Shares”
means the Correvio Shares to be issued in exchange for Cardiome Shares pursuant to the Arrangement;


 


“Contract” means any
contract, agreement, license, franchise, lease, arrangement, commitment, understanding, joint venture, partnership or other right
or obligation (written or oral) to which a Party or any of its subsidiaries is a party or by which a Party or any of its subsidiaries
is bound or to which any of their respective properties or assets is subject;


 




    	 	- 5 -	 



     


    

  


“Correvio” means Correvio
Pharma Corp., a corporation incorporated under the CBCA, that is and will be a wholly-owned subsidiary of Cardiome immediately
prior to the Effective Time;


 


“Correvio Canada” means
a corporation to be incorporated under the CBCA, that is and will be a wholly-owned subsidiary of Cardiome immediately prior to
the Effective Time;


 


“Correvio Canada Shares”
means issued and outstanding common shares in the capital of Correvio Canada;


 


“Correvio Indemnified Parties”
has the meaning ascribed thereto in Subsection 9.2(a);


 


“Correvio Replacement Option”
has the meaning ascribed thereto in Subsection 2.16(a);


 


“Correvio Shares” means
the issued and outstanding common shares in the capital of Correvio;


 


“Correvio Option Plan”
means the stock option plan of Correvio to be adopted by Correvio prior to the Effective Time, having identical terms and conditions
to the Cardiome Option Plan (except all references to Cardiome shall be references to Correvio);


 


“Court” means the Supreme
Court of British Columbia;


 


“CRG Loan” means the
amended and restated term loan agreement dated as of May 11, 2017 among Cardiome and its senior lenders (and their agent, CRG Servicing
LLC) and all agreements ancillary thereto;


 


“Damages” has the meaning
ascribed thereto in Section 9.4;


 


“Damages Claim” has
the meaning ascribed thereto in Section 9.4;


 


“Depositary” means Computershare
Trust Company of Canada, appointed for the purpose of, among other things, exchanging certificates representing Cardiome Shares
for certificates representing Consideration Shares;


 


“Director” means the
Director appointed pursuant to Section 260 of the CBCA;


 


“Direct Claim” has the
meaning ascribed thereto in Section 9.4;


 


“Dissent Rights” means
the rights of dissent exercisable by the Cardiome Shareholders under Section 190 of the CBCA in respect of the Arrangement, as
described in the Plan of Arrangement;


 


“Dissenting Shareholder”
has the meaning ascribed thereto in the Plan of Arrangement;


 


“Effective Date” means
the date shown on the Certificate of Arrangement giving effect to the Arrangement, which shall be no later than the Outside Date;


 


“Effective Time” has
the meaning ascribed thereto in the Plan of Arrangement;


 


“Employee Obligations”
has the meaning ascribed thereto in Section 5.3;


 


“Employee Plans” means
all benefit, bonus, incentive, pension, retirement, savings, stock purchase, profit sharing, stock option, stock appreciation,
phantom stock, termination, change of control, life insurance, medical, health, welfare, hospital, dental, vision care, drug, sick
leave, disability, and similar plans, programmes, arrangements or practices relating to any current or former director, officer
or employee of Cardiome or any of its subsidiaries;


 




    	 	- 6 -	 



     


    

  


"Encumbrance" includes
any mortgage, pledge, assignment, charge, lien, claim, security interest, adverse interest, adverse claim, other third person interest
or encumbrance of any kind, whether contingent or absolute, and any agreement, option, right or privilege (whether by Law, Contract
or otherwise) capable of becoming any of the foregoing;


 


“Environmental Laws”
means all Laws aimed at, or relating to, the reclamation or restoration of properties, protection of the environment, abatement
of pollution, protection of wildlife, ensuring public safety from environmental hazards, occupational health and safety, and all
other Laws relating to the management processing, use, treatment, storage, disposal, discharge, transport or handling of any Hazardous
Substances;


 


“Environmental Permits”
means any Permits issued or required under any Environmental Law;


 


“Exchange Ratio” means
a ratio of one (1) Consideration Share for each one (1) Cardiome Share; provided however, that the Cardiome Board may by resolution
determine to adjust and set the number of Cardiome Shares in such ratio at any number between one (1) and ten (10) so as to permit
compliance with any applicable stock exchange requirements;


 


“Final Order” means
an order of the Court granted pursuant to Section 192 of the CBCA, in a form acceptable to the Parties, each acting reasonably,
approving the Arrangement after a hearing upon the procedural and substantive fairness of the terms and conditions of the Arrangement,
as such order may be affirmed, amended, modified, supplemented or varied by the Court (with the consent of the Parties, each acting
reasonably) at any time prior to the Effective Date or, if appealed, as affirmed or amended (provided, however, that any such amendment
is acceptable to the Parties, each acting reasonably) on appeal, unless such appeal is withdrawn, abandoned or denied;


 


“Governmental Entity”
means (i) any multinational or supranational body or organization, nation, government, state, province, country, territory, municipality,
quasi-government, administrative, judicial or regulatory authority, agency, board, body, bureau, commission, instrumentality, court
or tribunal or any political subdivision thereof, or any central bank (or similar monetary or regulatory authority) thereof, any
taxing authority, any ministry or department or agency of any of the foregoing, (ii) any self-regulatory organization or stock
exchange, including the TSX and Nasdaq, (iii) any entity exercising executive, legislative, judicial, regulatory or administrative
functions of or pertaining to government; and (iv) any corporation or other entity owned or controlled, through stock or capital
ownership or otherwise, by any of such entities or other bodies pursuant to the foregoing;


 


“Hazardous Substance”
means any waste or other substance that is prohibited, listed, defined, designated or classified as hazardous, radioactive, corrosive,
explosive, infectious, carcinogenic, or toxic or a pollutant or a contaminant under or pursuant to, or that could result in any
Liability under, any applicable Environment Laws including petroleum and all derivatives thereof or synthetic substitutes therefor,
hydrogen sulphide, arsenic, cadmium, lead, mercury, polychlorinated biphenyls (“PCBs”), PCB-containing equipment
and material, mould, asbestos, asbestos-containing material, urea-formaldehyde, urea-formaldehyde-containing material and any other
material or substance that may impair the environment;


 


“Holdback Amount” means
an amount equal to (i) $1,000,000, if all of the conditions referenced in Subsections 6.1(i), 6.1(j) and 6.1(k) have been satisfied
on prior to the Effective Time, or (ii) $2,500,000, in any other case, which amount forms part of the Share Purchase Consideration
and shall be paid to Correvio pursuant to the terms and conditions of Section 9.9;


 


“including” means including
without limitation, and “include” and “includes” have a corresponding meaning;


 


“Indemnification Claim”
has the meaning ascribed thereto in Section 9.4;


 


“Indemnified Party”
means a Cardiome Indemnified Party or Cipher Indemnified Party, as applicable;


 




    	 	- 7 -	 



     


    

  


“Intellectual Property Assets”
means the Intellectual Property Rights owned or licensed by Cardiome which form part of the Retained Assets, as listed in Schedule
C(x) of the Cardiome Disclosure Letter;


 


“Intellectual Property Rights”
means all rights in intellectual property and industrial property, whether or not registrable, patentable or otherwise formally
protectable, and whether or not registered, patented, otherwise formally protected or the subject of a pending application for
registration, patent or any other formal protection, including all rights, titles, interests, and benefits in and to (a) trade-marks,
trade dress, corporate, partnership and business names and other trade names, (b) inventions, patent rights, arts, processes, machines,
manufactures, compositions of matter, (c) copyrights, software and databases, (d) designs and industrial designs, (e) know-how,
trade secrets, proprietary information, formulae, recipes, systems, methods and techniques and related documentation, customer
and supplier information, and market and survey information, (f) telephone numbers, domain names and social media identities, and
all derivatives, modifications and improvements of the foregoing;


 


“Inter-company Agreements”
means any agreements between Cardiome and one or more of its subsidiaries;


 


“Interim Order” means
an order of the Court in a form acceptable to the Parties, each acting reasonably, providing for, among other things, the calling
and holding of the Cardiome Meeting, as the same may be amended by the Court with the consent of the Parties, each acting reasonably;


 


“Key Regulatory Approvals”
means those sanctions, rulings, consents, orders, exemptions, permits and other approvals of Governmental Entities, necessary to
proceed with the transactions contemplated by this Agreement and the Plan of Arrangement, including but not limited to, in relation
to Cardiome, the approval of the TSX and Nasdaq in respect of the Arrangement and the grant of the Interim Order and the Final
Order, as listed in Schedule C(i) of the Cardiome Disclosure Letter;


 


“Key Third Party Consents”
means those notices, consents or approvals required to be delivered to or obtained from any third party (other than any Governmental
Entity), including under any Contract, to proceed with the transactions contemplated by this Agreement and the Plan of Arrangement,
as listed in Schedule C(i) of the Cardiome Disclosure Letter;


 


“Law” means, with respect
to any Person, any and all applicable law (statutory, common or otherwise), constitution, treaty, convention, ordinance, code,
rule, regulation, order, injunction, judgment, decree, ruling or other similar requirement, whether domestic or foreign, enacted,
adopted, promulgated or applied by a Governmental Entity that is binding upon or applicable to such Person or its business, undertaking,
property or securities, and to the extent that they have the force of law, policies, guidelines, notices and protocols of any Governmental
Entity, as amended;


 


"Liability" means, in
respect of any Person, any debt, liability or obligation of any kind or nature whatsoever, including (i) any right against such
Person to payment, whether or not such right is reduced to judgment, liquidated, unliquidated, fixed, contingent, matured, unmatured,
disputed, undisputed, legal, equitable, secured or unsecured, (ii) any right against such Person to an equitable remedy for breach
of performance if such breach gives rise to a right to payment, whether or not such right to any equitable remedy is reduced to
judgment, fixed, contingent, matured, unmatured, disputed, undisputed, secured or unsecured, and (iii) any obligation of such Person
for the performance of any covenant or agreement (whether for the payment of money or otherwise);


 


“Losses” means any and
all loss, liability, damage, cost, expense, charge, fine, penalty or assessment, interest charges, punitive damages, fines, penalties
and reasonable professional fees and disbursements, including in connection with any Claim;


 




    	 	- 8 -	 



     


    

  


“Material Adverse Effect”
means any effect that is, or would reasonably be expected to be, material and adverse to the Retained Assets or Retained Liabilities,
taken as a whole, or the business, condition (financial or otherwise), properties, assets (tangible or intangible), liabilities
(whether absolute, accrued, conditional or otherwise), operations or results of operations of Cardiome and its subsidiaries, taken
as a whole, other than any effect relating to or affecting, as applicable (i) the Canadian economy, political conditions (including
the outbreak of war or any acts of terrorism) or securities markets in general, (ii) the pharmaceutical industry in general, (iii)
any generally applicable change in Laws (other than orders, judgments or decrees against Cardiome or any of its subsidiaries),
or (iv) a change in the market trading price of the Cardiome Shares that is either (A) related to this Agreement and the Arrangement
or the announcement thereof, or (B) primarily a result of a change, effect, event or occurrence excluded from this definition of
Material Adverse Effect referred to in clause (i), (ii) or (iii) above; provided, however, that the effect referred to in clause
(i), (ii) or (iii) above does not primarily relate to (or have the effect of primarily relating to) Cardiome and its subsidiaries,
taken as a whole, or disproportionately adversely affect Cardiome and its subsidiaries, taken as a whole, compared to other companies
of similar size operating in the industry in which Cardiome and its subsidiaries operate;


 


“material change”, “material
fact” and “misrepresentation” have the meanings ascribed thereto in the Securities Act;


 


“MI 61-101” means Multilateral
Instrument 61-101 - Protection of Minority Security Holders in Special Transactions;


 


“Moved SARL Plus SA Assets”
means those assets listed Schedule J;


 


“Moved Trevyent Assets”
means those assets listed in Schedule I;


 


“Nasdaq” means the Nasdaq
Capital Market;


 


“New Canadian Product”
has the meaning ascribed thereto in Subsection 7.6(a);


 


“Notice of Acceptance”
has the meaning ascribed thereto in Subsection 7.6(b);


 


“ordinary course of business”,
“ordinary course of business consistent with past practice”, or any similar reference, means, with respect to
an action taken by a Person, that such action is consistent with the past practices of such Person and is taken in the ordinary
course of the normal day-to-day business and operations of such Person; provided that in any event such action is not unreasonable
or unusual;


 


“Offered Interest” has
the meaning ascribed thereto in Subsection 7.6(a);


 


“Office Lease” means
the office lease agreement between Cardiome and Central 1 Credit Union dated July 23, 2014;


 


“Option Period” has
the meaning ascribed thereto in Subsection 7.6(b);


 


“Outside Date” means
June 30, 2018 or such later date as may be agreed to in writing by the Parties;


 


“Parties” means, collectively,
Cardiome, Correvio and Cipher and “Party” means any one of them;


 


“Permit” means any license,
permit, certificate, consent, order, grant, approval, agreement, classification, restriction, registration or other Authorization
of, from or required by any Governmental Entity;


 


“Person” includes any
individual, firm, partnership, limited partnership, limited liability partnership, joint venture, venture capital fund, limited
liability company, unlimited liability company, association, trust, trustee, executor, administrator, legal personal representative,
estate, body corporate, corporation, company, unincorporated association or organization, Governmental Entity, syndicate or other
entity, whether or not having legal status;


 




    	 	- 9 -	 



     


    

  


“Plan of Arrangement”
means the plan of arrangement of Cardiome, substantially in the form attached as Schedule A, and any amendments or variations thereto
made from time to time in accordance with this Agreement, the Plan of Arrangement or upon the direction of the Court in the Interim
Order or the Final Order with the consent of the Parties, each acting reasonably;


 


“Pre-Closing Reorganization”
has the meaning ascribed thereto in Subsection 2.17(a);


 


“PSU Plan” means Cardiome’s
2014 Phantom Share Unit Plan adopted with effect from December 6, 2014;


 


“PSUs” means, as of
any date, phantom share units issued under the PSU Plan outstanding as of such date;


 


“Representative” means,
collectively, in respect of a Person, its subsidiaries and its affiliates and its and their respective officers, directors, employees,
consultants, advisors, agents or other representatives (including financial, legal or other advisors);


 


“Retained Assets” means
only those assets listed in Schedule F and includes the Books and Records;


 


“Retained Employees”
means only those employees of Cardiome or its subsidiaries listed in Schedule H;


 


“Retained Liabilities”
means only those Liabilities listed in Schedule G;


 


“Right of First Refusal”
has the meaning ascribed thereto in Subsection 7.6(b);


 


“RSU Plan” means Cardiome’s
Amended Restricted Share Unit Plan adopted with effect from May 9, 2014;


 


“RSUs” means, as of
any date, restricted share units issued under the RSU Plan outstanding as of such date;


 


“SEC” means the U.S.
Securities and Exchange Commission;


 


“Securities Act” means
the Securities Act (British Columbia) and the rules, regulations and published policies made thereunder, as now in effect
and as they may be promulgated or amended from time to time;


 


“Securities Authorities”
means all applicable securities regulatory authorities, including the applicable securities commissions or similar regulatory authorities
in each of the provinces and territories of Canada and the TSX, Nasdaq and the SEC;


 


“Securities Laws” means
the Securities Act, together with all other applicable Canadian provincial securities laws, the U.S. Securities Act, U.S. Exchange
Act, and applicable securities laws of the United States and the states thereof, and the rules and regulations and published policies
of the securities authorities thereunder, as now in effect and as they may be promulgated or amended from time to time, and includes
the rules and policies of the TSX and Nasdaq;


 


“Share Purchase Consideration”
means an amount equal to $25,500,000 to be paid by Cipher to Correvio as payment for all of the outstanding Cardiome Shares held
by Correvio pursuant to the terms of the Arrangement (inclusive, for greater certainty, of the Holdback Amount);


 


“Sublicense Agreement (Trevyent)”
means a sublicense and supply agreement to be entered into between Correvio International Sarl and Cardiome, in substantially the
form agreed to by the Parties as of the date hereof (and as approved by SteadyMed Ltd.), pursuant to which Cardiome will be granted
certain rights with respect of the commercialization of Trevyent® (a drug device combination that delivers Remodulin® (treprostinil))
in Canada;


 




    	 	- 10 -	 



     


    

  


“Sublicense Agreement (Xydalba)”
means a sublicense and supply agreement to be entered into between Correvio International Sarl and Cardiome, in substantially the
form agreed to by the Parties as of the date hereof (and as approved by Allergan Pharmaceuticals International Limited), pursuant
to which Cardiome will be granted certain rights with respect of the commercialization of XydalbaTM (dalbavancin hydrochloride)
in Canada;


 


“subsidiary” has the
meaning ascribed thereto in the Securities Act;


 


“Superior Proposal”
means any bona fide Acquisition Proposal that relates to the acquisition of 100% of the outstanding Cardiome Shares, made
in writing by a third party or third parties acting jointly or in concert with one another, who deal at arm’s length to Cardiome,
that in the good faith determination of the Cardiome Board, after receipt of advice from its outside financial advisor and legal
counsel: (i) is reasonably capable of being completed in accordance with its terms without undue delay, taking into account all
legal, financial, regulatory and other aspects of such proposal and the party making such proposal; (ii) in respect of which any
required financing to complete such Acquisition Proposal has been demonstrated to be available; (iii) is not subject to a due diligence
or access condition; (iv) did not result from a breach of Article 7; (v) is made available to all Cardiome Shareholders on the
same terms and conditions; (vi) failure to recommend such Acquisition Proposal to the Cardiome Shareholders would be inconsistent
with the Cardiome Board’s fiduciary duties; and (vii) taking into account all of the terms and conditions of such Acquisition
Proposal, if consummated in accordance with its terms (but not assuming away any risk of non-completion), would result in a transaction
more favourable to Cardiome Shareholders, from a financial point of view, than the Arrangement (after taking into account any adjustment
to the terms and conditions of the Arrangement proposed by Cipher pursuant to Section 7.3);


 


“Superior Proposal Notice”
has the meaning ascribed thereto in Subsection 7.3(a)(iv);


 


“Superior Proposal Notice Period”
has the meaning ascribed thereto in Subsection 7.3(a)(iv);


 


“Tax Act” means the
Income Tax Act (Canada) and the regulations made thereunder, as now in effect and as they may be promulgated or amended
from time to time;


 


“Tax Returns” means
all returns, reports, declarations, elections, notices, filings, forms, statements and other documents (whether in tangible, electronic
or other form) and including any amendments, schedules, attachments, supplements, appendices and exhibits thereto, made, prepared,
filed or required to be made, prepared or filed by Law in respect of Taxes;


 


“Taxes” means any and
all domestic and foreign federal, state, provincial, municipal and local taxes, assessments and other governmental charges, duties,
impositions and liabilities imposed by any Governmental Entity, including without limitation pension plan contributions, tax instalment
payments, unemployment insurance contributions and employment insurance contributions, workers’ compensation and deductions
at source, including taxes based on or measured by gross receipts, income, profits, sales, capital, use, and occupation, and including
goods and services, value added, ad valorem, sales, capital, transfer, franchise, non-resident withholding, customs, payroll, recapture,
employment, excise and property duties and taxes, together with all interest, penalties, fines and additions imposed with respect
to such amounts;


 


“Termination Payment”
means an amount equal to $2,500,000;


 


“Termination Payment Event”
has the meaning ascribed thereto in Subsection 8.4(a);


 


“Third Party Claim”
has the meaning ascribed thereto in Section 9.4;


 




    	 	- 11 -	 



     


    

  


“Transfer Agreement”
means the transfer agreement / bill of sale to be entered into on the Effective Date, between the Cardiome and Correvio, which
effects the sale, conveyance, grant, transfer and assignment to Correvio of all of Cardiome’s, right, title or interest in
or to the Assigned Assets;


 


“Transfer Offer” has
the meaning ascribed thereto in Subsection 7.6(a);


 


“Transaction Personal Information”
has the meaning ascribed thereto in Section 10.1;


 


“TSX” means the Toronto
Stock Exchange;


 


“United States” means
the United States of America, its territories and possessions, any state of the United States and the District of Columbia;


 


“U.S. Exchange Act”
means the United States Securities Exchange Act of 1934, as amended and the rules and regulations promulgated thereunder;


 


“U.S. GAAP” means United
States generally accepted accounting principles;


 


“U.S. Securities Act”
means the United States Securities Act of 1933, as amended and the rules and regulations promulgated thereunder; and


 


“U.S. Tax Code” has
the meaning ascribed thereto in Section 2.14;


 


		1.2	Interpretation



 


For the purposes of this Agreement, except
as otherwise expressly provided:


 


		(a)	“this Agreement” means this Arrangement Agreement, including the recitals and
Schedules hereto, and not any particular Article, Section, Subsection or other subdivision, recital or Schedule hereof, and includes
any agreement, document or instrument entered into, made or delivered pursuant to the terms hereof, as the same may, from time
to time, be supplemented or amended and in effect;



 


		(b)	the words “hereof”, “herein”, “hereto”
and “hereunder” and other words of similar import refer to this Agreement as a whole and not to any particular
Article, Section, Subsection, or other subdivision, recital or Appendix hereof;



 


		(c)	all references in this Agreement to a designated “Article”, “Section”,
“Subsection” or other subdivision, recital or “Schedule” hereof are references to the designated
Article, Section, Subsections or other subdivision, recital or Schedule to, this Agreement;



 


		(d)	the division of this Agreement into Article, Sections, Subsections and other subdivisions, recitals
or Schedule, the inclusion of a table of contents and the insertion of headings and captions are for convenience of reference only
and are not intended to interpret, define or limit the scope, extent or intent of this Agreement or any provision hereof;



 


		(e)	a reference to a statute in this Agreement includes all regulations, rules, policies or instruments
made thereunder, all amendments to the statute, regulations, rules, policies or instruments in force from time to time, and any
statutes, regulations, rules, policies or instruments that supplement or supersede such statute, regulations, rules, policies or
instruments; and



 


		(f)	the word “including” is not limiting, whether or not non-limiting language (such as
“without limitation” or “but not limited to” or words of similar import) is used with reference thereto.



 




    	 	- 12 -	 



     


    

  


		1.3	Number, Gender and Persons



 


In this Agreement, unless the context otherwise
requires, words importing the singular shall include the plural and vice versa, words importing the use of either gender shall
include both genders and neuters and the word person and words importing persons shall include a natural person, firm, trust, partnership,
association, corporation, joint venture or government (including any governmental agency, political subdivision or instrumentality
thereof) and any other entity or group of persons of any kind or nature whatsoever.


 


		1.4	Date for Any Action



 


If the date on which any action is required
to be taken hereunder by a Party is not a Business Day, such action shall be required to be taken on the next succeeding day which
is a Business Day.


 


		1.5	Currency



 


Unless otherwise stated, all references
in this Agreement to sums of money are expressed in lawful money of Canada and “$” refers to Canadian dollars. All
references to US$ refers to Untied States dollars.


 


		1.6	Accounting Matters



 


Unless otherwise stated, all accounting
terms used in this Agreement in respect of Cardiome shall have the meanings attributable thereto under U.S. GAAP and all determinations
of an accounting nature in respect of Cardiome required to be made shall be made in a manner consistent with U.S. GAAP consistently
applied.


 


		1.7	Knowledge



 


Where any representation or warranty is
expressly qualified by reference to the knowledge of Cardiome, it shall be deemed to refer to the actual knowledge, after making
reasonable inquiries regarding the relevant subject matter, of any of William Hunter (President and Chief Executive Officer), Justin
Renz (Chief Financial Officer), David Dean (Chief Business Development Officer) and David McMasters (General Counsel).


 


		1.8	Schedules



 


The following Schedules are annexed to
this Agreement and are incorporated by reference into this Agreement and form a part hereof:


 


Schedule A – Plan of Arrangement


 


Schedule B – Cardiome Arrangement
Resolution


 


Schedule C – Representations
and Warranties of Cardiome


 


Schedule D – Representations
and Warranties of Correvio


 


Schedule E – Representations
and Warranties of Cipher


 


Schedule F – Retained Assets


 


Schedule G – Retained Liabilities


 


Schedule H – Retained Employees


 




    	 	- 13 -	 



     


    

  


Schedule I – Moved Trevyent
Assets


 


Schedule J – Moved SARL
Plus SA Assets


 


Article
2

THE ARRANGEMENT


 


		2.1	Arrangement



 


The Parties agree that the Arrangement
will be implemented in accordance with and subject to the terms and conditions contained in this Agreement and the Plan of Arrangement.


 


		2.2	Obligations



 


		(a)	Subject to the terms and conditions of this Agreement, in order to facilitate the Arrangement,
Cardiome will take all action reasonably necessary in accordance with all applicable Laws, including Securities Laws, to:



 


		(i)	to make and diligently prosecute a motion to the Court for the Interim Order in connection with
the application for the Final Order in respect of the Arrangement;



 


		(ii)	in accordance with the terms of and the procedures contained in the Interim Order, duly call, give
notice of, convene and hold the Cardiome Shareholder Meeting as soon as practicable, and in any event not later than May 23, 2018,
to vote upon the Arrangement;



 


		(iii)	solicit proxies of the Cardiome Shareholders in favour of the Cardiome Arrangement Resolution and
against any resolution submitted by any Person that is inconsistent with the Cardiome Arrangement Resolution and the completion
of any of the transactions contemplated by this Agreement;



 


		(iv)	provide Cipher with copies of or access to information regarding the Cardiome Shareholder Meeting
generated by any dealer and/or proxy solicitation agent, as requested from time to time by Cipher;



 


		(v)	consult with Cipher in fixing the date of the Cardiome Shareholder Meeting, give notice to Cipher
of the Cardiome Shareholder Meeting and allow Cipher’s Representatives (including legal counsel) to attend the Cardiome Shareholder
Meeting;



 


		(vi)	not change the record date for the Cardiome Shareholders entitled to vote at the Cardiome Shareholder
Meeting, including in connection with any adjournment or postponement of the Cardiome Shareholder Meeting, unless required by applicable
Law;



 


		(vii)	subject to obtaining the approvals as contemplated in the Interim Order and as may be directed
by the Court in the Interim Order, take all steps necessary or desirable to submit the Arrangement to the Court and appear at Court
to seek the Final Order as soon as reasonably practicable (and, in any event, within five (5) Business Days following the approval
of the Cardiome Shareholder Meeting); and



 


		(viii)	deliver the Articles of Arrangement to the Director in accordance with Section 2.8 upon satisfaction
or waiver of the conditions set out in Article 6.



 


		2.3	Interim Order



 


As soon as reasonably practicable, Cardiome
shall apply to the Court in a manner and on terms acceptable to Cipher, acting reasonably, pursuant to Section 192 of the CBCA
and, in cooperation with Cipher, prepare, file and diligently pursue an application for the Interim Order, which shall provide,
among other things:


 




    	 	- 14 -	 



     


    

  


		(a)	for the class of Persons to whom notice is to be provided in respect of the Arrangement and the
Cardiome Meeting and for the manner in which such notice is to be provided;



 


		(b)	fix the record date for the purposes of determining the Cardiome Shareholders entitled to receive
notice of and vote at the Cardiome Meeting;



 


		(c)	that the requisite approval for the Cardiome Arrangement Resolution shall be at least two-thirds
of the votes cast by the Cardiome Shareholders present in person or by proxy at the Cardiome Meeting and such other approval, if
any, as is required pursuant to MI 61-101 (the “Cardiome Shareholder Approval”);



 


		(d)	that, in all other respects, the terms, conditions and restrictions of the constating documents
of Cardiome, including quorum requirements and other matters, shall apply in respect of the Cardiome Meeting;



 


		(e)	for the grant of Dissent Rights to the Cardiome Shareholders who are registered Cardiome Shareholders,
as set out in the Plan of Arrangement;



 


		(f)	that the Cardiome Meeting may be adjourned or postponed from time to time by Cardiome subject to
the terms of this Agreement without the need for additional approval of the Court;



 


		(g)	for the notice requirements with respect to the presentation of the application to the Court for
the Final Order;



 


		(h)	that the record date for Cardiome Shareholders entitled to notice of and to vote at the Cardiome
Meeting will not change in respect of any adjournment(s) of the Cardiome Meeting, unless required pursuant to applicable Securities
Laws;



 


		(i)	that the Parties intend to rely upon the exemption from registration provided by Section 3(a)(10)
of the U.S. Securities Act with respect to the issuance of the Consideration Shares and the Correvio Replacement Options to be
issued pursuant to the Arrangement;



 


		(j)	that each Cardiome Shareholder and holder of Cardiome Options shall have the right to appear before
the Court at the hearing of the Court to approve the application for the Final Order so long as they enter a notice of appearance
within a reasonable time; and



 


		(k)	for such other matters as Cipher and/or Cardiome may reasonably require, subject to obtaining the
prior consent of Cardiome and/or Cipher, respectively, such consent not to be unreasonably withheld or delayed.



 


		2.4	Cardiome Meeting



 


Subject to the terms of this Agreement:


 


		(a)	Cardiome agrees to convene and conduct the Cardiome Meeting in accordance with the Interim Order,
the constating documents of Cardiome and applicable Law as soon as practicable with a current target date of May 9, 2018, and in
any event not later than May 23, 2018.



 


		(b)	Cardiome shall not adjourn, postpone or cancel (or propose or permit the adjournment, postponement
or cancellation of) the Cardiome Meeting without Cipher’s prior written consent, except:



 




    	 	- 15 -	 



     


    

  


		(i)	as required for quorum purposes (in which case the meeting will be adjourned and not cancelled)
or by applicable Law or by a Governmental Entity; or



 


		(ii)	as otherwise required or permitted under this Agreement;



 


provided, however,
that, if Cardiome provides Cipher with a Superior Proposal Notice prior to the Cardiome Meeting, Cardiome may, and shall upon the
request of Cipher, adjourn the Cardiome Meeting to a date that is not less than five (5) Business Days and not more than fifteen
(15) days after the date of the Superior Proposal Notice.


 


		(c)	Cardiome will advise Cipher from time to time as Cipher may reasonably request, and at least on
a daily basis on each of the last ten (10) Business Days prior to the date of the Cardiome Meeting, as to the aggregate tally of
the proxies received by Cardiome in respect of the Cardiome Arrangement Resolution.



 


		(b)	Cardiome will promptly advise Cipher of any written communication from or written claims brought
by (or threatened, orally or in writing, to be brought by) any Person in opposition to the Arrangement and/or purported exercise
by any Cardiome Shareholder of Dissent Rights received by Cardiome and any withdrawal of Dissent Rights received by Cardiome and
any written communications sent by or on behalf of Cardiome to any Cardiome Shareholder exercising or purporting to exercise Dissent
Rights. Cardiome shall not settle or compromise, or agree to settle or compromise, any such claims without the prior written consent
of Cipher, not to be unreasonably withheld or delayed.



 


		(c)	Except as required by applicable Laws, Cardiome will not propose or submit for consideration at
the Cardiome Shareholder Meeting any business other than the Arrangement and the approval of the Cardiome Arrangement Resolution
without Cipher’s prior written consent, which consent shall not be unreasonably withheld or delayed.



 


		2.5	Cardiome Circular



 


		(a)	As soon as reasonably practicable following execution of this Agreement, but subject to Subsection 2.5(c),
Cardiome shall (i) prepare, in consultation with Cipher, the Cardiome Circular, together with any other documents required by applicable
Laws, and (ii) cause the Cardiome Circular to be sent to Cardiome Shareholders and holders of Cardiome Options and filed in all
jurisdictions where the same is required to be filed, all in accordance with all applicable Laws and the Interim Order. Cardiome
shall ensure that the Cardiome Circular complies in all material respects with all applicable Laws and, without limiting the generality
of the foregoing, that the Cardiome Circular represents full, true and plain disclosure of all material facts concerning Cardiome
and does not include any misrepresentation (other than with respect to any information relating solely to Cipher and provided by
Cipher for inclusion in the Cardiome Circular) and contains sufficient detail to permit the Cardiome Shareholders to form a reasoned
judgement concerning the matters to be placed before them at the Cardiome Meeting.



 


		(b)	Cardiome shall disclose in the Cardiome Circular:



 


		(i)	that the Cardiome Board has received a fairness opinion from the Cardiome Financial Advisor that
the Arrangement is fair, from a financial point of view, to the Cardiome Shareholders;



 


		(ii)	the general terms of the fairness opinion from the Cardiome Financial Advisor and such fairness
opinion shall be included in the Cardiome Circular;



 


		(iii)	that the Cardiome Board has unanimously determined, after receiving financial and legal advice,
that (i) the Arrangement is fair and reasonable to the Cardiome Shareholders, (ii) the Arrangement is in the best interests of
Cardiome, and (iii) the Cardiome Board recommends that the Cardiome Shareholders vote in favour of the Cardiome Arrangement Resolution;
and



 




    	 	- 16 -	 



     


    

  


		(iv)	that each director and senior officer of Cardiome intends to vote all of such Person’s Cardiome
Shares (including any Cardiome Shares issued upon the exercise of any securities convertible, exercisable or exchangeable into
Cardiome Shares) in favour of the Cardiome Arrangement Resolution, subject to the other terms of this Agreement and the Cardiome
Voting Agreements.



 


		(c)	Cipher shall promptly provide to Cardiome all information regarding Cipher or its subsidiaries
and affiliates, as required by the Interim Order and applicable Laws for inclusion in the Cardiome Circular, or in any amendments
or supplements to such Cardiome Circular. Cipher shall ensure that no such information provided by Cipher for inclusion in the
Cardiome Circular will contain any misrepresentation concerning Cipher.



 


		(d)	Cipher and its legal counsel shall be given a reasonable opportunity to review and comment on the
Cardiome Circular and all such other documents and the Cardiome Circular and all such other documents shall be in form and substance
satisfactory to Cipher, acting reasonably, before they are printed and mailed to Cardiome Shareholders or filed with any Governmental
Entity, subject to any disclosure obligations imposed on Cardiome by any Securities Authorities.



 


		(e)	Each of Cardiome and Cipher shall promptly notify the other Party if at any time before the Effective
Date either becomes aware that the Cardiome Circular contains a misrepresentation, or otherwise requires an amendment or supplement,
and the Parties shall co-operate in the preparation of any amendment or supplement to the Cardiome Circular as required or appropriate,
and Cardiome shall promptly mail or otherwise publicly disseminate any amendment or supplement to the Cardiome Circular to Cardiome
Shareholders and, if required by the Court or applicable Laws, file the same with any Governmental Entity and as otherwise required.



 


		(f)	Cardiome shall keep Cipher informed of any material requests or comments made by any Securities
Authorities in connection with the Cardiome Circular and promptly provide Cipher with copies of any correspondence received by
Cardiome from, or sent by Cardiome to, any Securities Authorities in connection with the Cardiome Circular.



 


		2.6	Final Order



 


If the Interim Order is obtained and the
Cardiome Arrangement Resolution is passed at the Cardiome Meeting as required by applicable Law then, subject to the terms of this
Agreement, Cardiome shall as soon as practicable (and, in any event, within five (5) Business Days following the approval of the
Cardiome Shareholder Meeting) apply to the Court for the Final Order pursuant to Section 192(4)(e) of the CBCA approving the Arrangement
on terms reasonably satisfactory to each of Cardiome and Cipher.


 




    	 	- 17 -	 



     


    

  


		2.7	Court Proceedings



 


Cardiome will provide Cipher and its legal
counsel with a reasonable opportunity to review and comment upon drafts of all material to be filed with the Court in connection
with the Interim Order and the Final Order, and will give reasonable consideration to all such comments. Subject to applicable
Law, Cardiome will not file any material with the Court in connection with the Interim Order and the Final Order, or serve any
such material, and will not agree to modify or amend materials so filed or served, except as contemplated by this Agreement, the
Plan of Arrangement, or with Cipher’s prior written consent, such consent not to be unreasonably withheld, conditioned or
delayed; provided, however, that nothing herein shall require Cipher to agree or consent to any increase in the Share Purchase
Consideration or other modification or amendment to such filed or served materials that expands or increases Cipher’s obligations
set forth in any such filed or served materials or under this Agreement or the Plan of Arrangement, or diminishes or limits Cipher’s
and/or Cardiome’s rights in respect of the Retained Assets following the Effective Time. Cardiome shall also provide to Cipher
and to Cipher’s legal counsel on a timely basis copies of any notice of appearance or other Court documents served on Cardiome
in respect of the application for the Interim Order or the Final Order or any appeal therefrom and of any notice, whether written
or oral, received by Cardiome indicating any intention to oppose the granting of the Interim Order or the Final Order or to appeal
the Interim Order or the Final Order. Cardiome will ensure that all materials filed with the Court in connection with the Interim
Order and the Final Order, are consistent in all material respects with the terms of this Agreement and the Plan of Arrangement.
In addition, Cardiome will not object to legal counsel to Cipher making such submissions on the hearing of the motion for the Interim
Order and the application for the Final Order as such counsel considers appropriate, provided, however, that Cardiome is advised
of the nature of any submissions prior to the hearing and such submissions are consistent with this Agreement and the Plan of Arrangement.
Cardiome will also oppose any proposal from any party that the Final Order contain any provision inconsistent with this Agreement,
and, if at any time after the issuance of the Final Order and prior to the Effective Date, Cardiome is required by the terms of
the Final Order or by Law to return to Court with respect to the Final Order, it shall do so after notice to, and in consultation
and cooperation with, Cipher.


 


		2.8	Articles of Arrangement and Effective Date



 


		(a)	The Articles of Arrangement shall implement the Plan of Arrangement and will become effective as
of the Effective Time. On the second (2nd) Business Day after the satisfaction or, where permitted, the waiver of the
conditions (excluding conditions that, by their terms, cannot be satisfied until the Effective Date, but subject to the satisfaction
or, where not prohibited, the waiver of those conditions as of the Effective Date) set forth in Article 6, unless another time
or date is agreed to in writing by the Parties, the Articles of Arrangement shall be filed by Cardiome with the Director, provided,
however, that the Articles of Arrangement shall not be sent to the Director, for endorsement and filing by the Director, except
as contemplated hereby or with Cipher’s prior written consent. From and after the Effective Time, the Plan of Arrangement
will have all of the effects provided by applicable Law, including the CBCA. Each of Cardiome and Cipher agrees to amend the Plan
of Arrangement at any time prior to the Effective Time in accordance with Section 8.6 of this Agreement to include such other
terms determined to be reasonably necessary or desirable by Cipher or Cardiome, as the case may be, provided, however, that the
Plan of Arrangement shall not be amended in any manner which has the effect of changing the Share Purchase Consideration or the
Consideration, or which is otherwise prejudicial to the Cardiome Shareholders or other parties to be bound by the Plan of Arrangement
or is inconsistent with the provisions of this Agreement.



 


		(b)	The closing of the Arrangement will take place at the offices of Blake, Cassels & Graydon LLP
in Vancouver, British Columbia at 10:00 a.m. (Vancouver time) on the Effective Date, or at such other time and place as may be
agreed to by the Parties. The Parties acknowledge that the Effective Date is currently targeted to occur on May 14, 2018,



 


		2.9	Payment of Consideration



 


		(a)	Correvio will, following receipt by Cardiome of the Final Order and prior to the filing by Cardiome
of the Articles of Arrangement, deposit in escrow with the Depositary sufficient Consideration Shares to pay the aggregate Consideration
payable by Correvio to Cardiome Shareholders on the Effective Date pursuant to the Plan of Arrangement.



 


		(b)	Cipher will, following receipt by Cardiome of the Final Order and prior to the filing by Cardiome
of the Articles of Arrangement, make arrangements satisfactory to Correvio, acting reasonably, to pay the aggregate Share Purchase
Consideration (less the Holdback Amount calculated in accordance with Section 9.9) to Correvio, in immediately available funds,
on the Effective Date pursuant to the Arrangement.



 




    	 	- 18 -	 



     


    

  


		2.10	Announcements and Consultations



 


Cipher and Cardiome shall consult with
each other in respect to issuing any press release, preparing any presentations or otherwise making any public statement with respect
to this Agreement or the Arrangement and in making any filing with any Governmental Entity with respect to this Agreement or the
Arrangement. Each of Cipher and Cardiome shall use commercially reasonable efforts to enable the other Party to review and comment
on all such press releases, presentations, public statements and filings prior to the release or filing, respectively, thereof,
and neither Cipher nor Cardiome shall release, make or file any press release, presentation, public statements or filing without
the prior written consent of the other Party (which consent shall not be unreasonably withheld or delayed); provided, however,
that the obligations herein shall not prevent a Party from making such disclosure as is required by applicable Laws or the rules
and policies of any applicable stock exchange, and the Party making such disclosure shall use all commercially reasonable efforts
to enable the other Party to review or comment on the disclosure or filing, and if such prior notice is not possible, to give such
notice immediately following the making of such disclosure or filing. Reasonable consideration shall be given to any comments made
by the other Party and its counsel.


 


		2.11	Withholding Taxes



 


The Parties, the Depositary and any Person
on their behalf shall be entitled to deduct and withhold from any consideration payable or otherwise deliverable to any Person
hereunder and from all dividends, interest or other amounts payable to any Person (including, for greater certainty, any Cardiome
Shareholder, any Dissenting Shareholder, any holder of RSUs or any holder of PSUs) such amounts as any of the Parties or the Depositary
or any Person on their behalf may be required or permitted to deduct and withhold therefrom under any provision of applicable Laws
in respect of Taxes. To the extent that such amounts are so deducted, withheld and remitted, such amounts shall be treated for
all purposes under this Agreement as having been paid to the Person to whom such amounts would otherwise have been paid. The Parties
and the Depositary shall also have the right to withhold and sell, on their own account or through a broker, and on behalf of any
aforementioned Person to whom a withholding obligation applies, or require such Person to irrevocably direct the sale through a
broker and irrevocably direct the broker to pay the proceeds of such sale to the Parties or the Depositary, as appropriate, such
number of Consideration Shares issued to such Person pursuant to the Arrangement as is necessary to produce sale proceeds (after
deducting commissions payable to the broker and other costs and expenses) sufficient to fund any withholding obligations. None
of the Parties or the Depositary will be liable for any Loss arising out of any sale.


 


		2.12	List of Shareholders



 


Subject to Section 10.1, at the reasonable
request of Cipher from time to time, Cardiome shall provide Cipher with a list (in both written and electronic form) of the registered
Cardiome Shareholders, together with their addresses and respective holdings of Cardiome Shares, with a list of the names and addresses
and holdings of all Persons having rights issued by Cardiome to acquire Cardiome Shares and a list of non-objecting beneficial
owners of Cardiome Shares, together with their addresses and respective holdings of Cardiome Shares. Cardiome shall from time to
time furnish Cipher with such additional information, including updated or additional lists of Cardiome Shareholders and lists
of holders of Cardiome Options, Cardiome Warrants, PSUs or RSUs, and such other assistance as Cipher may reasonably request.


 


		2.13	U.S. Securities Law Matters



 


The Parties agree that the Arrangement
will be carried out with the intention that all Consideration Shares and Correvio Replacement Options issued pursuant to the Arrangement
will be issued by Correvio in reliance on the exemption from the registration requirements of the U.S. Securities Act provided
by Section 3(a)(10) thereunder. In order to ensure the availability of the exemption under Section 3(a)(10) of the U.S. Securities
Act, the Parties agree that the Arrangement will be carried out on the following basis:


 




    	 	- 19 -	 



     


    

  


		(a)	the Arrangement will be subject to the approval of the Court;



 


		(b)	the Court will be advised as to the intention of the Parties to rely on the exemption under Section
3(a)(10) of the U.S. Securities Act prior to the hearing required to approve the Arrangement;



 


		(c)	the Court will be required to satisfy itself as to the procedural and substantive fairness of the
terms and conditions of the Arrangement to the Cardiome Shareholders and holders of Cardiome Options;



 


		(d)	Cardiome will ensure that each Person entitled to receive Consideration Shares and Correvio Replacement
Options on completion of the Arrangement will be given adequate notice advising them of their right to attend the hearing of the
Court to give approval of the Arrangement and providing them with sufficient information necessary for them to exercise that right;



 


		(e)	each Person entitled to receive Consideration Shares or Correvio Replacement Options will be advised
that the Consideration Shares and Correvio Replacement Options issued pursuant to the Arrangement have not been registered under
the U.S. Securities Act and will be issued by Correvio in reliance on the exemption under Section 3(a)(10) of the U.S. Securities
Act;



 


		(f)	the Final Order approving the Arrangement that is obtained from the Court will state that the Arrangement
is approved by the Court as being substantively and procedurally fair to the Cardiome Shareholders and the holders of Cardiome
Options; and



 


		(g)	the Interim Order approving the Cardiome Meeting will specify that each Cardiome Shareholder and
each other holder of Cardiome Options will have the right to appear before the Court at the hearing of the Court to give approval
of the Arrangement so long as they enter an appearance within a reasonable time.



 


		2.14	United States Tax Matters



 


The Parties agree that
(a) the exchange is intended to qualify as a reorganization within the meaning of 368(a)(1)(B) of the U.S. Internal Revenue Code
(the “U.S. Tax Code”); (b) the Plan of Arrangement is intended to be a “plan of reorganization”
within the meaning of the Treasury Regulations promulgated under Section 368 of the U.S. Tax Code for purposes of Sections 354
and 361 of the U.S. Tax Code and (c) the reorganization is intended to qualify as a nonrecognition transaction for purposes of
the U.S. Tax Code.


 


		2.15	Canadian Income Tax Matters



 


		(a)	Section 85.1.  It is intended that pursuant to the Arrangement each outstanding
Cardiome Share will be exchanged for Consideration Shares and no other consideration such that the share exchange qualifies under
Section 85.1 of the Tax Act.



 


		(b)	Subsection 85(1) Tax Election.
Cardiome shall, and Correvio shall cause Correvio Canada to, elect jointly in the prescribed form under subsection 85(1) of the
Tax Act within the time period permitted under the Tax Act and under any other applicable provincial or territorial statute at
an elected amount that results in the transfer of the Brinavess Assets from Cardiome to Correvio Canada in exchange for
the issuance of 100 common shares in the capital of Correvio Canada to
Cardiome under the Plan of Arrangement taking place on a tax-free basis. Cardiome shall file such election within the time period
prescribed under subsection 85(6) of under the Tax Act.



 


		(c)	Section 22 Tax Election.
If available, Correvio and Cardiome shall elect jointly in the prescribed form under section 22 of the Tax Act and the corresponding
provisions of any other applicable Tax statute as to the sale of any receivables from Cardiome to Correvio and designate in such
election an amount equal to the fair market value of such receivables. This election, or these elections, shall be made within
the time prescribed for such elections.



 




    	 	- 20 -	 



     


    

  


		(d)	Subsection 20(24) Tax Election.
Correvio and Cardiome shall, if applicable, jointly execute and file an election under subsection 20(24) of the Tax Act in the
manner required by subsection 20(25) of the Tax Act and under the equivalent or corresponding provisions of any other applicable
provincial or territorial statute, in the prescribed forms and within the time period permitted under the Tax Act and under any
other applicable provincial or territorial statute, as to such amount paid by Cardiome to Correvio for assuming future obligations.
In this regard, Correvio and Cardiome acknowledge that a portion of the assets of Cardiome transferred by Cardiome to Correvio
pursuant to the Arrangement and having a value equal to the amount elected under subsection 20(24) of the Tax Act and the equivalent
provisions of any applicable provincial or territorial statute, is being transferred by Cardiome as a payment for the assumption
of such future obligations by Correvio.



 


		(e)	Other Tax Elections. Correvio
and Cardiome shall also execute and deliver such other Tax elections and forms as they may mutually agree upon.



 


		(f)	GST and PST. To the extent
that a transfer of assets from Cardiome to Correvio or from Cardiome to Correvio Canada, as the case may be, is subject to GST
under the Excise Tax Act (Canada) or provincial sales tax (“PST”) under the Provincial Sales Tax Act
(British Columbia), or both, Cardiome shall collect on or before the Effective Time from Correvio or Correvio Canada, or from
both, as the case may be, and remit to the appropriate Government Entity the appropriate amount of GST or PST, or both.



 


		(g)	Purchase Exemption Certificates. Correvio shall provide Cardiome with properly completed
purchase exemption certificates, or their equivalent, where applicable, to support any reasonable exemption claimed by Correvio
in respect of provincial sales tax.



 


		(h)	Payment of Taxes. Except as otherwise may be provided in this Agreement, Correvio, or Correvio
Canada as the case may be, shall pay all Taxes applicable to, or resulting from the transactions contemplated by, this Agreement
(other than Taxes payable by Cardiome under applicable Law as arising as of and after the Effective Time) and any filing, registration,
recording or transfer fees payable in connection with the instruments of transfer provided for in this Agreement.



 


		2.16	Incentive Plan Matters



 


		(a)	Each Cardiome Option outstanding immediately prior to the Effective Time shall be exchanged for
an option (each, a “Correvio Replacement Option”) to purchase from Correvio, without further act or formality,
the number of Correvio Shares equal to the product of (A) the number of Cardiome Shares subject to the Cardiome Option immediately
before the Effective Time, and (B) the Exchange Ratio, provided that if the foregoing would result in the issuance of a fraction
of a Correvio Share on any particular exercise of Correvio Replacement Options, then the number of Correvio Shares otherwise issued
shall be rounded down to the nearest whole number of Correvio Shares. The exercise price per Correvio Share subject to any such
Correvio Replacement Option shall be an amount equal to the quotient of (A) the exercise price per Cardiome Share under the exchanged
Cardiome Option immediately prior to the Effective Time divided by (B) the Exchange Ratio (provided that the aggregate exercise
price payable on any particular exercise of Correvio Replacement Options shall be rounded up to the nearest whole cent). Except
as set out above, all terms and conditions of a Correvio Replacement Option, including the term to expiry, conditions to and manner
of exercising, will be the same as the Cardiome Option for which it was exchanged, and shall be governed by the terms of the Correvio
Option Plan and any document evidencing a Cardiome Option shall thereafter evidence and be deemed to evidence such Correvio Replacement
Option. If the exchange contemplated by this paragraph results in a disposition of Cardiome Options, it is intended that the provisions
of subsection 7(1.4) of the Tax Act apply to any such disposition. Accordingly, and notwithstanding the foregoing, if required,
the exercise price of a Correvio Replacement Option will be increased such that the In-The-Money Amount (as defined in the Plan
of Arrangement) of the Correvio Replacement Option immediately after the exchange does not exceed the In-The-Money Amount of the
Cardiome Option immediately before the exchange.



 




    	 	- 21 -	 



     


    

  


		(b)	Immediately following the issuance of the Correvio Replacement Options pursuant to the Plan of
Arrangement, the Cardiome Option Plan shall be terminated. Following the Effective Time, Cardiome shall have no further Liability
with respect to the Cardiome Option Plan or any Cardiome Options (or any Liability to any former holder thereof).



 


		(c)	Each Cardiome Warrant shall be adjusted in accordance with the adjustment provisions in the relevant
warrant certificate or warrant indenture and Correvio covenants and agrees to be bound by the terms of such warrant certificate
or warrant indenture. Following the Effective Time, Cardiome shall have no further Liability with respect to any Cardiome Warrants
(or any Liability to any holder or former holder thereof).



 


		(d)	Each RSU outstanding immediately prior to the Effective Time (whether vested or unvested), notwithstanding
the terms of the RSU Plan, shall be deemed to be unconditionally vested, and such RSU shall, without any further action by or on
behalf of a holder of RSUs, be deemed to be assigned and transferred by such holder to Cardiome in exchange for a cash payment
from Cardiome equal to the fair market value of each RSU on the trading day two days prior to the Effective Date, subject to applicable
withholdings, and each such RSU shall immediately be cancelled. Following the Effective Time, Cardiome shall have no further Liability
with respect to any Cardiome RSUs (or any Liability to any holder or former holder thereof).



 


		(e)	Each PSU outstanding immediately prior to the Effective Time (whether vested or unvested), notwithstanding
the terms of the PSU Plan, shall be deemed to be unconditionally vested, and such PSU shall, without any further action by or on
behalf of a holder of PSUs, be deemed to be assigned and transferred by such holder to Cardiome in exchange for a cash payment
from Cardiome equal to the fair market value of each PSU on the trading day two days prior to the Effective Date, subject to applicable
withholdings, and each such PSU shall immediately be cancelled. Following the Effective Time, Cardiome shall have no further Liability
with respect to any Cardiome PSUs (or any Liability to any holder or former holder thereof).



 


		2.17	Reorganization



 


		(a)	Prior to the Effective Time, Cardiome shall, or shall cause certain subsidiaries (as identified
below) to, carry out the following transactions (the “Pre-Closing Reorganization”), which Pre-Closing Reorganization
is hereby specifically acknowledged and permitted by the Parties to occur on or prior to the Effective Date:



 


		(i)	Cardiome shall cause Correvio Canada to be incorporated as a wholly owned subsidiary of Cardiome
and shall cause Correvio Canada to be registered for the purposes of the Excise Tax Act (Canada);



 


		(ii)	Cardiome shall assign any and all of its right, title or interest in or to the Moved Trevyent Assets
to Correvio International Sarl, in consideration of Correvio International Sarl issuing to Cardiome, a non-interest bearing promissory
note with a principal amount equal to the fair market value of Cardiome’s interest in the Moved Trevyent Assets;



 


		(iii)	Cardiome and Correvio International Sarl shall enter into the Sublicense Agreement (Trevyent) and
Sublicense Agreement (Xydalba) as partial repayment of an existing loan from Cardiome to Correvio International Sarl by an amount
equal to the aggregate fair market value of the Sublicense Agreement (Trevyent) and Sublicense Agreement (Xydalba); and



 




    	 	- 22 -	 



     


    

  


		(iv)	Cardiome International SA, Correvio International Sarl and Cardiome (UK) Ltd., shall assign any
and all of their right, title or interest in or to the Moved SARL Plus SA Assets to Cardiome as partial repayment of existing loans
from Cardiome to Cardiome International SA, Correvio International Sarl and Cardiome (UK) Ltd. by an amount equal to the aggregate
fair market value of the Moved SARL Plus SA Assets transferred by each to Cardiome.



 


		(b)	After the Effective Time, if the Effective Time is on or prior to June 28, 2018, and in any event
prior to June 30, 2018, Cardiome International SA and Correvio International Sarl shall amalgamate and continue as one corporation.



 


		(c)	Cardiome shall provide to Cipher all documentation reasonably requested by Cipher related to the
Pre-Closing Reorganization for its review and comment at least five (5) Business Days prior to the Effective Date.



 


Article
3

REPRESENTATIONS AND WARRANTIES OF CARDIOME AND CORREVIO


 


		3.1	Representations and Warranties of Cardiome



 


Cardiome represents and warrants to Cipher
as set forth in Schedule C, except to the extent that such representations and warranties are qualified by the Cardiome Disclosure
Letter (which shall make reference to the corresponding section or subsection of Schedule C), and acknowledges and agrees that
Cipher is relying upon such representations and warranties in connection with the entering into of this Agreement and the completion
of the transactions contemplated herein. Any investigation by Cipher or its Representatives shall not mitigate, diminish or affect
the representations and warranties of Cardiome pursuant to this Agreement.


 


		3.2	Survival of Representations and Warranties of Cardiome



 


The representations and warranties of Cardiome
contained in this Agreement shall not survive the completion of the Arrangement and shall expire and be terminated on the earlier
of the Effective Time and the date on which this Agreement is terminated in accordance with its terms.


 


		3.3	Representations and Warranties of Correvio



 


Correvio represents and warrants to Cipher
as set forth in Schedule D, and acknowledges and agrees that Cipher is relying upon such representations and warranties in connection
with the entering into of this Agreement and the completion of the transactions contemplated herein. Any investigation by Cipher
or its Representatives shall not mitigate, diminish or affect the representations and warranties of Correvio pursuant to this Agreement.


 


		3.4	Survival of Representations and Warranties of Correvio



 


The representations and warranties of Correvio
contained in this Agreement shall not survive the completion of the Arrangement and shall expire and be terminated on the earlier
of the Effective Time and the date on which this Agreement is terminated in accordance with its terms.


 




    	 	- 23 -	 



     


    

  


Article
4

REPRESENTATIONS AND WARRANTIES OF CIPHER


 


		4.1	Representations and Warranties of Cipher



 


Cipher represents and warrants to Cardiome
as set forth in Schedule E, and acknowledges and agrees that Cardiome is relying upon such representations and warranties in connection
with the entering into of this Agreement and the completion of the transactions contemplated herein. Any investigation by Cardiome
or its Representatives shall not mitigate, diminish or affect the representations and warranties of Cipher pursuant to this Agreement.


 


		4.2	Survival of Representations and Warranties of Cipher



 


The representations and warranties of Cipher
contained in this Agreement shall not survive the completion of the Arrangement and shall expire and be terminated on the earlier
of the Effective Time and the date on which this Agreement is terminated in accordance with its terms.


 


Article
5

COVENANTS


 


		5.1	Covenants of Cardiome Relating to the Arrangement



 


Cardiome shall perform all obligations
required to be performed by Cardiome under this Agreement, co-operate with Cipher in connection therewith, and do all such other
acts and things as may be necessary or desirable in order to consummate and make effective, as soon as reasonably practicable,
the transactions contemplated in this Agreement and, without limiting the generality of the foregoing, Cardiome shall:


 


		(a)	apply for and use commercially reasonable efforts to obtain all Key Regulatory Approvals and all
Key Third Party Consents, keep Cipher reasonably informed as to the status of the proceedings related to obtaining the Key Regulatory
Approvals and Key Third Party Consents, including providing Cipher with copies of all related applications and notifications, in
draft form (except where such material is confidential in which case it will be provided (subject to applicable Laws) to Cipher’s
outside counsel on an “external counsel” basis), in order for Cipher to provide its comments thereon, which shall be
given due and reasonable consideration;



 


		(b)	use commercially reasonable efforts to satisfy all conditions precedent in this Agreement and take
all steps set forth in the Interim Order and Final Order applicable to it and comply promptly with all requirements which applicable
Laws may impose on Cardiome with respect to the Arrangement or the other transactions contemplated by this Agreement;



 


		(c)	use commercially reasonable efforts to obtain, effective as of the Effective Time, releases, in
favour of Cardiome, in respect of Liabilities under the Cardiome Material Contracts from the respective counterparties thereto,
in each case in form and substance acceptable to the Parties, each acting reasonably;



 


		(d)	if requested to do so in writing by Cipher on or before the fifth (5th) Business Day
before the Effective Date, terminate, cancel or withdraw, as applicable, any one or more of the contracts, attestations and statement
of works listed in subsections 5(h)(i) to (v) of Schedule F;



 


		(e)	defend all lawsuits or other legal, regulatory or other proceedings against Cardiome challenging
or affecting this Agreement or the consummation of the transactions contemplated hereby and use commercially reasonable efforts
to have lifted or rescinded any injunction or restraining order or other order relating to Cardiome which may materially impede
the ability of the Parties to consummate the Arrangement or the other transactions contemplated by this Agreement;



 




    	 	- 24 -	 



     


    

  


		(f)	not take any action that is intended to, or would reasonably be expected to, individually or in
the aggregate, prevent, materially delay or materially impede the ability of Cardiome to consummate the Arrangement or the other
transactions contemplated by this Agreement;



 


		(g)	prior to the Effective Time, terminate without any Liability to Cardiome all Inter-company Agreements,
except for those Inter-company Agreements that constitute Retained Assets or Retained Liabilities (as listed in Schedules F and
G, respectively);



 


		(h)	until the earlier of the Effective Time and termination of this Agreement in accordance with its
terms, subject to applicable Law, make available and cause to be made available to Cipher, and its Representatives, information
reasonably requested by Cipher for the purposes of preparing, considering and implementing integration and strategic plans for
the acquisition by Cipher of the Retained Assets and Retained Liabilities following the Effective Date and confirming the representations
and warranties of Cardiome set out in this Agreement, except as provided for in any sublicense or transition and supply agreements
entered into by the Parties regarding the Retained Assets and Retained Liabilities (and in which case the terms of such agreements
shall govern the conduct of the Parties); and



 


		(i)	until the earlier of the Effective Time and termination of this Agreement in accordance with its
terms, Cardiome shall, to the extent not precluded by applicable Law, promptly notify Cipher, in writing, when Cardiome has knowledge
of:



 


		(i)	any Material Adverse Effect or any change, effect, event, development, occurrence, circumstance
or state of facts which would reasonably be expected to have a Material Adverse Effect;



 


		(ii)	any notice or other communication from any Person alleging that the consent (or waiver, permit,
exemption, order, approval, agreement, amendment or confirmation) of such Person (or other Person) is or may be required in connection
with this Agreement or the Arrangement;



 


		(iii)	any notice or other communication from any Governmental Entity in connection with the Arrangement
or this Agreement (and contemporaneously provide a copy of any such written notice or communication to Cipher); or



 


		(iv)	any filing, actions, suits, claims, investigations or proceedings commenced or, to the knowledge
of Cardiome, threatened orally or in writing against, relating to or involving or otherwise affecting Cardiome, its subsidiaries
or any of their respective assets that would reasonably be expected to have a Material Adverse Effect.



 


		5.2	Covenants of Cardiome Relating to the Conduct of Business



 


Cardiome covenants and agrees that at all
times prior to the Effective Time, except as disclosed in the Cardiome Disclosure Letter or as otherwise expressly contemplated
or permitted by this Agreement (including, the Pre-Closing Reorganization permitted under Section 2.17 of this Agreement), or as
Cipher shall otherwise agree in writing, Cardiome shall, and shall cause its subsidiaries (as applicable) to:


 


		(a)	conduct its businesses and affairs related to the Retained Assets and Retained Liabilities in,
and not take any action related to the Retained Assets and Retained Liabilities except in, the ordinary course of business consistent
with past practice;



 


		(b)	use commercially reasonable efforts to maintain and preserve all of its material rights under each
Contract or Authorization related to any Retained Asset or Retained Liability;



 




    	 	- 25 -	 



     


    

  


		(c)	pay, discharge or satisfy, in the ordinary course of business consistent with past practice, Liabilities
reflected or reserved against in the Cardiome Financial Statements or incurred in the ordinary course of business consistent with
past practice, and not incur any new Liability outside the ordinary course of business;



 


		(d)	without limiting the foregoing, pay, discharge or satisfy the Retained Liabilities in the ordinary
course of business consistent with past practice;



 


		(e)	use commercially reasonable efforts to preserve intact its present business organization, the Retained
Assets and Retained Liabilities (including associated intellectual property) and goodwill related to the Retained Assets, and preserve
the current material relationships with suppliers, distributors, employees, consultants, customers and others having business relationships
with it related to the Retained Assets and Retained Liabilities;



 


		(f)	continue to employ the Retained Employees on their current terms and conditions;



 


		(g)	not:



 


		(i)	amend or propose to amend the articles or by-laws or
other constating documents of Cardiome;



 


		(ii)	except as contemplated by this Agreement, split, consolidate or reclassify, or propose to split,
consolidate or reclassify, any of the Cardiome Shares or undertake or propose to undertake any other capital reorganization or
change in the Cardiome Shares or any other securities of Cardiome;



 


		(iii)	amend the terms of any outstanding equity securities of Cardiome;



 


		(iv)	declare, set aside or pay any dividend or other distribution or payment (whether in cash, securities
or property or any combination thereof) in respect of the Cardiome Shares or any other securities of Cardiome,



 


		(v)	redeem, purchase or otherwise acquire, or offer to redeem, purchase or otherwise acquire, any Cardiome
Shares or any other securities of Cardiome;



 


		(vi)	adopt a plan of liquidation or resolution providing for the liquidation or dissolution of Cardiome;



 


		(vii)	acquire or agree to acquire (by merger, amalgamation, acquisition of shares or assets or otherwise)
any company, partnership or other business organization or division, or incorporate or form, or agree to incorporate or form, any
company, partnership or other business organization or make or agree to make any investment either by purchase of shares or securities,
contributions of capital, property transfer or purchase of, any property or assets of any other Person, company, partnership or
other business organization;



 


		(viii)	except as contemplated by this Agreement, pursue any corporate acquisition, merger or make any
other material change to its business or affairs;



 


		(ix)	enter into or agree to the terms of any joint venture or similar agreement, arrangement or relationship;



 


		(x)	sell, pledge, lease, dispose of or encumber any of the Retained Assets or Retained Liabilities,
except in the ordinary course of business consistent with past practice;



 




    	 	- 26 -	 



     


    

  


		(xi)	waive, release, grant or transfer any rights in respect of, or modify or change in any material
respect, any Retained Asset or Retained Liability, without first advising Cipher and obtaining Cipher’s consent and direction,
acting reasonably, as to any action to be taken in that regard, and forthwith taking any action directed by Cipher, acting reasonably;



 


		(xii)	take any action or fail to take any action which action or failure to act would result in the loss,
expiration or surrender of, or the loss of any material benefit under, or reasonably be expected to cause any Governmental Entities
to institute proceedings for the suspension, revocation or limitation of rights under, any material Authorizations relating to
any Retained Asset or Retained Liability; or fail to prosecute with commercially reasonable due diligence any pending applications
to any Governmental Entities relating to any Retained Asset or Retained Liability;



 


		(xiii)	waive, release, transfer, modify or amend, in any material respect, any Contract or Authorization
related to any Retained Asset or Retained Liability;



 


		(xiv)	enter into or adopt any shareholder rights plan or similar agreement or arrangement;



 


		(xv)	make any changes to existing accounting policies, other than as required by applicable Laws or
by U.S. GAAP;



 


		(xvi)	change any method of Tax accounting, make or change any Tax election, file any materially amended
Tax Returns, settle or compromise any Tax liability, agree to an extension or waiver of the limitation period with respect to the
assessment, reassessment, or determination of Taxes, enter into any closing agreement with respect to any Tax or surrender any
right to claim a material Tax refund;



 


		(xvii)	take any action that would reasonably be expected to interfere with or be inconsistent with the
completion of the Arrangement or the transactions contemplated in this Agreement; or



 


		(xviii)	announce an intention, enter into any formal or informal agreement, or otherwise make a commitment
to do any of the things prohibited by any of the foregoing subsections.



 


		(h)	Subject to Section 7.5, Cardiome shall use commercially reasonable efforts to cause its current
insurance (or re-insurance) policies not to be cancelled or terminated or any of the coverage thereunder to lapse before the Outside
Date, unless simultaneously with such termination, cancellation or lapse, replacement policies underwritten by insurance and re-insurance
companies of nationally recognized standing providing coverage equal to or greater than the coverage under the cancelled, terminated
or lapsed policies for substantially similar premiums are in full force and effect.



 


		(i)	(i) Duly and timely file all Tax Returns required to be filed by it on or after the date hereof
and all such Tax Returns will be true, complete and correct in all material respects; (ii) timely withhold, collect, remit and
pay all Taxes which are to be withheld, collected, remitted or paid by it to the extent due and payable, except for any Taxes contested
in good faith pursuant to applicable Laws or that are immaterial in amount (either individually or in the aggregate); (iii) not
make or rescind any material express or deemed election relating to Taxes except as required or desirable in respect of the Arrangement;
(iv) not make a request for a tax ruling or enter into a closing agreement with any taxing authorities; (v) not settle or compromise
any material claim, action, suit, litigation, proceeding, arbitration, investigation, audit or controversy relating to Taxes; and
(vi) not change in any material respect any of its methods of reporting income, deductions or accounting for income tax purposes
from those employed in the preparation of its income Tax Return for the tax year ending December 31, 2016, except as may be required
by applicable Laws.



 




    	 	- 27 -	 



     


    

  


		5.3	Transferred Employees



 


Cardiome shall terminate the employment
of all employees of Cardiome (other than the Retained Employees) as of the Effective Time and Correvio shall either offer employment
to all such employees of Cardiome, with effect from and after the Effective Time, on terms that are substantially the same as the
terms applicable to such employees when they were employees of Cardiome or make arrangements for the payment of termination pay
or severance to such employees, such payment obligations to be assumed by and be solely the responsibility of Correvio. From and
after the Effective Date, Correvio shall assume and be responsible for all obligations with respect to the engagement or employment
of all employees (other than Retained Employees) and directors of Cardiome engaged or employed by Cardiome prior to and as of the
Effective Time, including with respect to all notice of termination and severance pay in accordance with applicable Law (including
employment standards) and Contract, if applicable, obligations under Employee Plans and for all unpaid wages, accrued vacation
pay, change of control, and other amounts owing to employees or directors of Cardiome up to and as of the Effective Time (whether
payable before or after the Effective Time), and for all Claims of any nature or kind relating to employment or engagement by Cardiome
up to the Effective Time, including for breach of contract or wrongful dismissal. Cardiome shall retain liability and be responsible
for any amounts payable to all Retained Employees on account of their employment with Cardiome or the termination of that employment
that accrue or become payable after the Effective Date. The obligations contained in this Section 5.3 (the “Employee Obligations”)
shall survive the execution and delivery of this Agreement and the completion of the transactions contemplated by this Agreement,
including the Arrangement.


 


		5.4	Post-Closing Filings



 


Following the Effective Time, the Parties
shall co-operate with each other in respect of any filings to be made with Securities Authorities pursuant to applicable Securities
Laws or Governmental Entities arising in connection with, or resulting from, the Arrangement and other transactions contemplated
by this Agreement. Without limiting the foregoing, if Cipher is obliged to file a business acquisition report (“Business
Acquisition Report”) with Canadian Securities Authorities in respect of the Arrangement, pursuant to National Instrument
51-102 Continuous Disclosure Obligations (“NI 51-102”), Correvio shall provide all such assistance (at
the cost and expense of Cipher) as is reasonably necessary to prepare all such financial statements (including carve-out statements)
as may required to be included in the Business Acquisition Report, within the applicable time period prescribed by NI 51-102.


 


Article
6

CONDITIONS


 


		6.1	Mutual Conditions Precedent



 


The obligations of the Parties to complete
the Arrangement are subject to the fulfillment of each of the following conditions precedent on or before the Effective Time, each
of which may only be waived with the mutual written consent of the Parties without prejudice to their right to rely on any other
of such conditions:


 


		(a)	the Interim Order having been granted on terms consistent with this Agreement and the Interim Order
not having been set aside or modified in a manner unacceptable to any Party, acting reasonably, on appeal or otherwise;



 


		(b)	the Cardiome Arrangement Resolution having been passed by the Cardiome Shareholders in accordance
with the Interim Order;



 




    	 	- 28 -	 



     


    

  


		(c)	the Final Order having been granted on terms consistent with this Agreement and the Final Order
not having been set aside or modified in a manner unacceptable to any Party, acting reasonably, on appeal or otherwise;



 


		(d)	there shall have been no action taken under any applicable Law or by any Governmental Entity which
make it illegal or otherwise directly or indirectly restrains, enjoins or prohibits the completion of the Arrangement;



 


		(e)	the Key Regulatory Approvals shall have been obtained;



 


		(f)	the Key Third Party Consents shall have been obtained;



 


		(g)	the Transfer Agreement and all other documentation reasonably necessary for, or otherwise relating
to, the sale, conveyance, grant, transfer and assignment of the Assigned Assets to Correvio shall be in form and substance acceptable
to each Party, acting reasonably;



 


		(h)	the Assignment and Assumption Agreement and all other documentation reasonably necessary for, or
otherwise relating, the assumption of the Assumed Liabilities by Correvio shall be in form and substance acceptable to each Party,
acting reasonably;



 


		(i)	a release in favour of Cardiome in respect of Liabilities under the CRG Loan, in form and substance
acceptable to the Parties, each acting reasonably, shall have been obtained from the counterparties thereto;



 


		(j)	a release in favour of Cardiome in respect of Liabilities under the Office Lease, in form and substance
acceptable to the Parties, each acting reasonably, shall have been obtained from the counterparties thereto, or, alternatively,
a valid notice of termination of the Office Lease, in form and substance acceptable to the Parties, each acting reasonably, shall
have been delivered to the counterparties thereto;



 


		(k)	a release in favour of Cardiome in respect of Liabilities under the obligations of Cardiome as
a guarantor referenced in Schedule C(p) of the Disclosure Letter, in form and substance acceptable to the Parties, each acting
reasonably, shall have been obtained from the counterparties thereto;



 


		(l)	the Articles of Arrangement to be filed with the Director in accordance with this Agreement shall
be in form and substance acceptable to the Parties, each acting reasonably;



 


		(m)	the distribution of the Consideration Shares pursuant to the Arrangement shall be exempt from the
prospectus and registration requirements of applicable Canadian securities laws either by virtue of exemptive relief from the securities
regulatory authorities of each of the provinces of Canada or by virtue of applicable exemptions under Canadian securities laws
and shall not be subject to resale restrictions under applicable Canadian securities laws (other than as applicable to control
persons or pursuant to section 2.6 of National Instrument 45-102);



 


		(n)	the Consideration Shares and Correvio Replacement Options shall be exempt from the registration
requirements of the U.S. Securities Act pursuant to Section 3(a)(10) thereof based on the Court’s approval of the Arrangement;
provided however, that Cardiome shall not be entitled to rely on the provisions of this Subsection 6.1(l) in failing to complete
the transactions contemplated by this Agreement in the event that Cardiome fails to advise the Court prior to the hearing in respect
of the Final Order, as required by the terms of the foregoing exemptions, that Correvio will rely on the foregoing exemption based
on the Court’s approval of the Arrangement, and



 


		(o)	this Agreement shall not have been terminated in accordance with its terms.



 




    	 	- 29 -	 



     


    

  


		6.2	Additional Conditions Precedent in Favour of Cipher



 


The obligation of Cipher to complete the
Arrangement is subject to the fulfillment of each of the following additional conditions precedent on or before the Effective Time
(each of which is for the exclusive benefit of Cipher and may be only waived by Cipher):


 


		(a)	all covenants of Cardiome and Correvio under this Agreement to be performed on or before the Effective
Time which have not been waived by Cipher shall have been duly performed by Cardiome and Correvio in all material respects and
Cipher shall have received a certificate of each of Cardiome and Correvio addressed to Cipher and dated the Effective Date, signed
on behalf of each of Cardiome and Correvio by two of its senior executive officers (without personal liability), confirming the
same as of the Effective Date;



 


		(b)	the representations and warranties of Cardiome and Correvio set forth in this Agreement shall be
true and correct in all respects, without regard to any materiality or Material Adverse Effect qualifications contained in them
as of the Effective Time, as though made on and as of the Effective Time (except for representations and warranties made as of
a specified date, the accuracy of which shall be determined as of that specified date), except where the failure or failures of
all such representations and warranties to be so true and correct in all respects would not reasonably be expected to have a Material
Adverse Effect, provided however that it is understood and agreed that the representations and warranties set out in paragraphs
(a), (d), (f), (g), (i), (r) and (ee) of Schedule C and (a), (d), (e) and (g) of Schedule D must be true and correct in all respects
when made on and as of the Effective Time, and Cipher shall have received a certificate of each of Cardiome and Correvio addressed
to Cipher and dated the Effective Date, signed on behalf of each of Cardiome and Correvio by two of its senior executive officers
(without personal liability), confirming the same as at the Effective Date;



 


		(c)	the Sublicense Agreement (Trevyent) shall have been entered into with effect prior to or as of
the Effective Time;



 


		(d)	the Sublicense Agreement (Xydalba) shall have been entered into with effect prior to or as of the
Effective Time;



 


		(e)	the Ancillary Agreements (Aggrastat), in form and substance acceptable to Cipher, acting reasonably,
shall have been entered into with effect prior to or as of the Effective Time;



 


		(f)	the Ancillary Agreements (Brinavess), in form and substance acceptable to Cipher, acting reasonably,
shall have been entered into with effect prior to or as of the Effective Time;



 


		(g)	any Retained Assets, to the extent not held by Cardiome as of the date hereof, will be transferred
or assigned to Cardiome, to the satisfaction of Cipher, acting reasonably, with effect prior to or as of the Effective Time;



 


		(h)	there shall not have occurred a Material Adverse Effect that has not been publicly disclosed by
Cardiome prior to the date hereof, and since the date of this Agreement, there shall not have occurred a Material Adverse Effect,
and Cipher shall have received a certificate of Cardiome addressed to Cipher and dated the Effective Date, signed on behalf of
Cardiome by two of its senior executive officers (without personal liability), confirming the same as at the Effective Date;



 


		(i)	there shall be no suit, action or proceeding by any Governmental Entity or any other Person that
has resulted in an imposition of material limitations on the ability of Cipher to acquire or hold, or exercise full rights of ownership
of, any Cardiome Shares; and



 




    	 	- 30 -	 



     


    

  


		(j)	Cipher shall have received all of the Cardiome Voting Agreements executed by the Cardiome Supporting
Shareholders and all covenants of the Cardiome Supporting Shareholders under the Cardiome Voting Agreements to be performed on
or before the Effective Time which have not been waived by Cipher shall have been duly performed by the parties thereto (other
than Cipher) in all material respects.



 


The foregoing conditions will be for the
sole benefit of Cipher and may be waived by it in whole or in part at any time.


 


		6.3	Additional Conditions Precedent in Favour of Cardiome



 


The obligation of Cardiome to complete
the Arrangement is subject to the fulfillment of each of the following additional conditions precedent on or before the Effective
Time (each of which is for the exclusive benefit of Cardiome and may be waived only by Cardiome):


 


		(a)	all covenants of Cipher under this Agreement to be performed on or before the Effective Time which
have not been waived by Cardiome shall have been duly performed by Cipher in all material respects and Cardiome shall have received
a certificate of Cipher addressed to Cardiome and dated the Effective Date, signed on behalf of Cipher by two of its senior executive
officers (without personal liability), confirming the same as of the Effective Date;



 


		(b)	the representations and warranties of Cipher set forth in this Agreement shall be true and correct
in all respects, without regard to any materiality or material adverse effect qualifications contained in them as of the Effective
Time, as though made on and as of the Effective Time (except for representations and warranties made as of a specified date, the
accuracy of which shall be determined as of that specified date), except where the failure or failures of all such representations
and warranties to be so true and correct in all respects would not reasonably be expected to have a material adverse effect, and
Cardiome shall have received a certificate of Cipher addressed to Cardiome and dated the Effective Date, signed on behalf of Cipher
by two senior executive officers of Cipher (without personal liability), confirming the same as at the Effective Date;



 


		(c)	Cardiome shall have received satisfactory evidence of the conditional approval for listing of the
Consideration Shares from the TSX and Nasdaq, subject only to customary listing conditions of the TSX and Nasdaq;



 


		(d)	Cipher shall have made arrangements satisfactory to Correvio, acting reasonably, to pay the aggregate
Share Purchase Consideration (less the Holdback Amount) to Correvio, in immediately available funds, on the Effective Date pursuant
to the Arrangement; and



 


		(e)	holders of no more than five percent (5%) of the Cardiome Shares shall have exercised, and at the
date of the Cardiome Meeting, have not withdrawn, Dissent Rights.



 


The foregoing conditions will be for the
sole benefit of Cardiome and may be waived by it in whole or in part at any time.


 


		6.4	Notice and Cure Provisions



 


		(a)	Each Party will give prompt notice to the other of the occurrence, or failure to occur, at any
time from the date hereof until the earlier to occur of the termination of this Agreement and the Effective Time, of any event
or state of facts which occurrence or failure would, or would be likely to:



 


		(i)	cause any of the representations or warranties of any Party contained herein to be untrue or inaccurate
in any material respect on the date hereof or at the Effective Time; or



 




    	 	- 31 -	 



     


    

  


		(ii)	result in the failure to comply with or satisfy any covenant, condition or agreement to be complied
with or satisfied by any Party hereunder prior to the Effective Time.



 


		(b)	Cipher may not exercise its rights to terminate this Agreement pursuant to Subsection 8.2(a)(iii)C
and Cardiome may not exercise its right to terminate this Agreement pursuant to Subsection 8.2(a)(iv)A unless the Party intending
to rely thereon has delivered a written notice to the other Party specifying in reasonable detail all breaches of covenants, representations
and warranties or other matters which the Party delivering such notice is asserting as the basis for the non-fulfilment or the
applicable condition or termination right, as the case may be. If any such notice is delivered, provided that a Party is proceeding
diligently to cure such matter and such matter is capable of being cured, no Party may terminate this Agreement until the expiration
of a period of three (3) Business Days from such notice, and then only if such matter has not been cured by such date. If such
notice has been delivered prior to the making of the application for the Final Order, such application and such filing shall be
postponed until the expiry of such period. For greater certainty, in the event that such matter is cured within the time period
referred to herein without a Material Adverse Effect, this Agreement may not be terminated as a result of the cured breach.



 


		6.5	Satisfaction of Conditions



 


Other than as set forth in this section,
the conditions precedent set out in Section 6.1, Section 6.2 and Section 6.3 shall be conclusively deemed to have
been satisfied, waived or released when the Certificate of Arrangement is issued by the Director following filing of the Articles
of Arrangement with the consent of the Parties in accordance with the terms of this Agreement.


 


Article
7

ADDITIONAL COVENANTS


 


		7.1	Covenant Regarding Non-Solicitation



 


Cardiome shall, and shall
direct and cause its Representatives to, immediately cease and cause to be terminated any solicitation, encouragement, activity,
discussion or negotiation with any parties that may be ongoing with respect to an Acquisition Proposal whether or not initiated
by Cardiome, and Cardiome shall request the return of information regarding Cardiome and its subsidiaries previously provided to
such parties and shall request the destruction of all materials including or incorporating any confidential information regarding
Cardiome and its subsidiaries. Cardiome agrees not to release any third party from any confidentiality agreement relating to a
potential Acquisition Proposal to which such third party is a party. Cardiome further agrees not to release any third party from
any standstill or similar agreement or obligation to which such third party is a party or by which such third party is bound (it
being understood and agreed that the automatic termination of a standstill provision due to the announcement of the Arrangement
or the entry into this Agreement shall not be a violation of this Section 7.1).


 


		7.2	Covenant Regarding Acquisition Proposal



 


		(a)	Subject to Section 7.3 or unless expressly permitted pursuant to this Section 7.2, Cardiome agrees
that it shall not, and shall not authorize or permit any of its Representatives, directly or indirectly, to:



 


		(i)	make, solicit, initiate, entertain, encourage, promote or facilitate, (including by way of furnishing
information, permitting any visit to its facilities or properties or entering into any form of agreement, arrangement or understanding)
any inquiries or the making of any proposals regarding an Acquisition Proposal or that may be reasonably be expected to lead to
an Acquisition Proposal;



 




    	 	- 32 -	 



     


    

  


		(ii)	participate, directly or indirectly, in any discussions or negotiations regarding, or furnish to
any Person any information or otherwise co-operate with, respond to, assist or participate in any Acquisition Proposal or potential
Acquisition Proposal, provided however that Cardiome may communicate and participate in discussions with a third party for the
purpose of (A) clarifying the terms of any proposal in order to determine if it may reasonably be expected to lead to a Superior
Proposal; and (B) advising such third party that an Acquisition Proposal does not constitute a Superior Proposal and cannot reasonably
be expected to result in a Superior Proposal;



 


		(iii)	remain neutral with respect to, or agree to, approve or recommend any, Acquisition Proposal or
potential Acquisition Proposal (it being understood that publicly taking no position or a neutral position with respect to an Acquisition
Proposal until five (5) Business Days following formal announcement of such Acquisition Proposal shall not be considered to be
a violation of this Subsection 7.2(a)(iii);



 


		(iv)	withdraw, modify, qualify or change in a manner adverse to Cipher, or publicly propose to or publicly
state that it intends to withdraw, modify, qualify or change in a manner adverse to Cipher, the approval, recommendation or declaration
of advisability of its Board or any committee thereof of this Agreement or the Arrangement (a “Change in Recommendation”)
(it being understood that failing to affirm the approval or recommendation of its Board of this Agreement or the Arrangement within
five (5) Business Days after an Acquisition Proposal has been publicly announced shall be considered to be an adverse modification);



 


		(v)	enter into any agreement, arrangement or understanding related to any Acquisition Proposal or requiring
it to abandon, terminate or fail to consummate the Arrangement or providing for the payment of any break, termination or other
fees or expenses to any Person in the event that the Arrangement is completed or in the event that it completes any other transaction
with Cipher or with an affiliate of Cipher that is agreed to prior to any termination of this Agreement; or



 


		(vi)	make any public announcement or take any other action inconsistent with the recommendation of its
Board to approve the Arrangement.



 


		(b)	Notwithstanding anything contained in this Section 7.2 and any other provisions of this Agreement:



 


		(i)	the Cardiome Board may consider, participate in any discussions or negotiations with and provide
information to, any Person who has delivered a written Acquisition Proposal which was not solicited or encouraged by Cardiome after
the date of this Agreement and did not otherwise result from a breach of this Section 7.2 and that the Cardiome Board determines
in good faith after consultation with its financial advisor and outside legal counsel that such Acquisition Proposal may reasonably
be expected to lead to a Superior Proposal; provided, however, that prior to taking any such action the Cardiome Board determines
in good faith, after consultation with outside counsel that it is necessary to take such action in order to discharge properly
its fiduciary duties, and if Cardiome provides confidential non-public information to such Person, Cardiome obtains a confidentiality
and standstill agreement from the Person making such Acquisition Proposal that is substantively the same as the Confidentiality
Agreement, and otherwise on terms no more favourable to such Person than the Confidentiality Agreement, including a standstill
provision at least as stringent as contained in the Confidentiality Agreement (provided that, such confidentiality agreement shall
not preclude such Person from making a Superior Proposal and such agreement shall not restrict or prohibit Cardiome from disclosing
to Cipher any details concerning the Acquisition Proposal or any Superior Proposal made by such Person). Cardiome shall be permitted
to provide such Person with access to information regarding Cardiome and its subsidiaries; provided that Cardiome sends a copy
of any such confidentiality agreement to Cipher promptly upon its execution and Cipher is provided with a list of the information
provided to such Person and is promptly provided with access to the same information to which such Person was provided.



 




    	 	- 33 -	 



     


    

  


		(ii)	Nothing in this Agreement shall prohibit the Cardiome Board from making a Change in Recommendation
or from making any disclosure to any of its securityholders prior to the Effective Time if, in the good faith judgment of such
Board, after consultation with outside legal counsel, failure to take such action or make such disclosure would be inconsistent
with the exercise of its fiduciary duties or such action or disclosure is otherwise required under applicable Law (including by
responding to an Acquisition Proposal under a directors’ circular or otherwise as required under applicable Securities Laws);
provided that, no Change in Recommendation may be made in relation to an Acquisition Proposal unless Cardiome complies with Section
7.3.



 


		(c)	Cardiome shall promptly (and in any event within 24 hours) notify Cipher, at first orally and then
in writing, of any proposals, offers or written inquiries relating to or constituting an Acquisition Proposal or any request for
non-public information relating to Cardiome or any of its subsidiaries. Such notice shall include a description of the terms and
conditions of any proposal, inquiry or offer, the identity of the Person making such proposal, inquiry or offer and provide such
other details of the proposal, inquiry or offer as Cipher may reasonably request. Cardiome shall keep Cipher fully informed on
a prompt basis of the status, including any change to the material terms, of any such proposal, inquiry or offer.



 


		(d)	Cardiome shall ensure that its officers, directors and any financial advisors or other advisors
or Representatives retained by it are aware of the provisions of this Section 7.2, and it shall be responsible for any breach of
this Section 7.2 by such officers, directors, financial advisors or other advisors or Representatives.



 


		7.3	Right to Accept a Superior Proposal



 


		(a)	If Cardiome has complied with Section 7.2 of this Agreement, Cardiome may accept, approve, recommend
or enter into any agreement, understanding or arrangement in respect of a Superior Proposal (other than a confidentiality agreement,
the execution of which shall not be subject to the conditions of this Section 7.3) received prior to the date of approval of the
Arrangement and the transactions contemplated by this Agreement by Cardiome’s Shareholders and terminate this Agreement if,
and only if:



 


		(i)	Cardiome has provided Cipher with a copy of the Superior Proposal document;



 


		(ii)	Cardiome has provided the other Party with the information regarding such Superior Proposal required
under Subsection 7.2(c);



 


		(iii)	the Cardiome Board has determined in good faith, after consultation with outside legal counsel
and its financial advisors, that it is necessary in order for the Cardiome Board to discharge properly its fiduciary duties to
withdraw or modify its approval or recommendation of this Agreement and to approve or recommend such Superior Proposal; and



 


		(iv)	five (5) Business Days (the “Superior Proposal Notice Period”) shall have elapsed
from the later of (A) the date Cipher received written notice (a "Superior Proposal Notice") advising it that
the Cardiome has resolved to accept, approve, recommend or enter into an agreement in respect of such Superior Proposal, subject
only to this Section 7.3, and (B) the date that Cipher received a copy of such Superior Proposal document.



 




    	 	- 34 -	 



     


    

  


In the event
that Cardiome provides Cipher with a Superior Proposal Notice on a date that is less than seven (7) Business Days prior to the
scheduled date of the Cardiome Meeting, Cardiome shall, at the request of Cipher, adjourn such meeting to a date that is not less
than five (5) Business Days and not more than fifteen (15) days after the date of the Superior Proposal Notice. If
the Cardiome Circular has been sent to Cardiome Shareholders prior to the expiry of the Superior Proposal Notice Period and, during
such period, Cipher requests in writing that the Cardiome Meeting proceed, unless otherwise ordered by a court, Cardiome shall
continue to take all reasonable steps necessary to hold the Cardiome Meeting and to cause the Arrangement and the transactions
contemplated by this Agreement to be voted on at such meeting.


 


		(b)	During the Superior Proposal Notice Period, Cardiome agrees that Cipher shall have the right, but
not the obligation, to offer in writing to amend the terms of this Agreement. The Cardiome will review any written proposal to
amend the terms of this Agreement in good faith in order to determine, in its discretion in the exercise of its fiduciary duties,
whether any such amended proposal would, upon acceptance by Cardiome, result in such Superior Proposal ceasing to be a Superior
Proposal. If the Cardiome Board so determines, Cardiome will enter into an amended agreement with Cipher reflecting the amended
proposal.



 


		(c)	Upon the expiry of the Superior Proposal Notice Period, if: (i) Cipher has determined not to offer
in writing to amend the terms of this Agreement pursuant to Subsection 7.3(b); or (ii) the Cardiome Board has determined that any
offer by Cipher in writing to amend the terms of this Agreement (pursuant to Subsection 7.3(b)) would, upon acceptance by Cardiome,
not result in any Superior Proposal ceasing to be a Superior Proposal, then Cardiome may accept, approve, recommend or enter into
an agreement, understanding or arrangement in respect of such Superior Proposal, subject to compliance with the Termination Payment
provisions in Section 8.4 of this Agreement.



 


		(d)	Cardiome also acknowledges and agrees that each successive material modification of any Acquisition
Proposal shall constitute a new Acquisition Proposal for purposes of the requirement under Subsection 7.3(a)(iv) and will initiate
a new and additional Superior Proposal Notice Period.



 


		7.4	Access to Information; Confidentiality; Transition



 


From the date hereof until the earlier
of the Effective Time and the termination of this Agreement pursuant to its terms, subject to compliance with applicable Law and
the terms of any existing Contracts: (a) Cardiome shall, and shall cause its Representatives to, afford to Cipher and to Representatives
of Cipher full access during normal business hours upon reasonable notice, to all properties, information and records relating
to Cipher, including but not limited to, all related facilities, books, contracts, financial statements, forecasts, financial projections
(to the extent permitted by confidentiality agreements in force on the date hereof), studies, records, operating Permits and any
other documentation (whether in writing or stored in computerized, electronic, disk, tape, microfilm or any other form) or materials
of any kind or nature whatsoever, and Cipher and Cardiome acknowledge and agree that information furnished pursuant to this Section
7.4 shall be subject to the terms and conditions of the Confidentiality Agreement; (b), Cardiome shall promptly notify Cipher of
any significant developments or material changes relating the Retained Assets and the Retained Liabilities, promptly after becoming
aware of any such development or change, and (c) each of Cipher and Correvio shall, and shall cause their subsidiaries and their
respective Representatives to, as the case may be, work cooperatively and in good faith to ensure an orderly transition following
the Effective Time, including with respect to transitional planning, transitional services, and the retention of personnel (and
any related arrangements thereto).


 




    	 	- 35 -	 



     


    

  


		7.5	Insurance and Indemnification



 


		(a)	Prior to the Effective Date, Cardiome may purchase customary “run-off” policies of
directors’ and officers’ liability insurance providing protection no less favourable in the aggregate to the protection
provided by the policies maintained by Cardiome which are in effect immediately prior to the Effective Date and providing protection
in respect of claims arising from facts or events which occurred on or prior to the Effective Date and Cipher will, or will cause
Cardiome to, maintain such tail policies in effect without any reduction in scope or coverage for six (6) years from the Effective
Date; provided that neither Cipher nor Cardiome shall be required to expend any funds in respect of this Section 7.5 following
the Effective Time (and Correvio shall be solely responsible for maintaining such policies, including the payment of all costs
and expenses associated therewith after the Effective Time).



 


		(b)	Following the Effective Time, Cardiome shall not be obligated to honour any rights to indemnification
or exculpation now existing in favour of present and former officers or directors of Cardiome and any such Liabilities shall constitute
Assumed Liabilities.



 


		7.6	ROFR on New Canadian Products



 


		(a)	For the period commencing on the Effective Date and expiring on date that is five (5) years following
the Effective Date, if Correvio or any of its affiliates receives from any Person a bona fide offer to license all or part
of any pharmaceutical product that Correvio or its affiliates do not have any Canadian rights to on the date of this Agreement
(each, a “New Canadian Product”), which Correvio is willing to accept (a “Transfer Offer”),
whether in whole or in part (the “Offered Interest”), Correvio shall give written notice to Cipher of the
Transfer Offer including all terms and of its intention to accept the Transfer Offer to Cipher.



 


		(b)	Within ninety (90) days after receipt by Cipher of the written notice of a Transfer Offer under
Subsection 7.6(a) (the “Option Period”), Cipher (or, for the purposes of this Section 7.6, any affiliate
of Cipher) shall be entitled to sublicense the Offered Interest on terms to be negotiated by and between Correvio and Cipher (the “Right
of First Refusal”). Cipher shall, within the Option Period, notify Correvio of its desire (the “Notice
of Acceptance”) to sublicense the Offered Interest. If Cipher fails to exercise its Right of First Refusal within the
Option Period, Cipher will be deemed to have definitively waived such Right of First Refusal.



 


		(c)	If Cipher elects to exercise its Right of First Refusal, the parties shall use commercially reasonable
efforts to complete such sublicense transaction within 60 days following the delivery of the Notice of Acceptance (or such
longer period as may reasonably be required to comply with all applicable statutory and regulatory requirements or to obtain all
required consents or as may be agreed to by Correvio and Cipher).



 


		(d)	If Cipher elects not to exercise, or is deemed to have waived, its Right of First Refusal, Correvio
shall be entitled to thereafter sublicense the Offered Interest offered pursuant to the Transfer Offer to any Person or to commercialize
the New Canadian Product itself.



 


		(e)	Notwithstanding the foregoing (or anything to the contrary in this Section 7.6), upon a change
of control of either Cipher or Correvio (being the acquisition (directly or indirectly) by any Person or group of Persons acting
jointly or in concert, of greater than 50% of the voting securities of either Cipher or Correvio) each of Cipher and Correvio shall
have the right, exercisable at any time within thirty (30) days following the date of such change of control, to terminate the
obligations of Cipher and Correvio under this Section 7.6.



 


		7.7	Product Introduction Fee



 


		(a)	For the period commencing on the Effective Date and expiring on December 31, 2019, if Correvio
or any of its affiliates introduces Cipher to any New Canadian Product and Cipher enters into a binding agreement to license all
or part of such New Canadian Product as a result of such an introduction, Cipher shall pay $500,000 to Correvio by wire transfer
of immediately available funds on the date that such binding agreement is entered into.



 




    	 	- 36 -	 



     


    

  


Article
8

TERM, TERMINATION, AMENDMENT AND WAIVER


 


		8.1	Term



 


This Agreement shall be effective from
the date hereof until the earlier of the Effective Time and the termination of this Agreement in accordance with its terms.


 


		8.2	Termination



 


		(a)	This Agreement may be terminated:



 


		(i)	at any time prior to the Effective Time by mutual written agreement of Cardiome and Cipher;



 


		(ii)	by either Cardiome or Cipher, if:



 


		A.	the Effective Time shall not have occurred on or before the Outside Date, except that the right
to terminate this Agreement under this Subsection 8.2(a)(ii)A shall not be available to any Party whose failure to fulfil
any of its obligations or breach any of its covenants, representations and warranties under this Agreement has been the cause of,
or resulted in, the failure of the Effective Time to occur by the Outside Date;



 


		B.	any Governmental Entity shall have issued an order, decree or ruling or there shall be enacted
or made any applicable Law that makes consummation of the Arrangement illegal or otherwise prohibited or otherwise restrains, enjoins
or prohibits Cardiome or Cipher from consummating the Arrangement (unless such order, decree, ruling or applicable Law has been
withdraw, reversed or otherwise made inapplicable) and such order, decree, ruling or applicable Law or enjoinment shall have become
final and non-appealable; or



 


		C.	Cardiome Shareholder Approval shall not have been obtained at the Cardiome Meeting in accordance
with applicable Laws and the Interim Order.



 


		(iii)	by Cipher, if:



 


		A.	prior to the Effective Time (1) the Cardiome Board shall have made a Change in Recommendation,
(2) the Cardiome Board shall have approved or recommended an Acquisition Proposal, or (3) Cardiome shall have entered into a definitive
agreement with respect to a Superior Proposal;



 


		B.	the Cardiome Meeting has not occurred on or before May 23, 2018 or such later date as may be agreed
by Cardiome and Cipher in writing, provided that the right to terminate this Agreement pursuant to this Section 8.2(a)(iii)B shall
not be available to Cipher if the failure by Cipher to fulfil any obligation hereunder is the cause of, or results in, the failure
of the Cardiome Meeting to occur on or before such date; or



 


		C.	subject to Section 6.4, Cardiome or Correvio is in default of a covenant or obligation hereunder
such that the condition contained in Subsection 6.2(a) would be incapable of satisfaction, or any representation or warranty of
Cardiome or Correvio under this Agreement is untrue or incorrect or shall have become untrue or incorrect such that the condition
contained in Subsection 6.2(b) would be incapable of satisfaction; provided that Cipher is not then in breach of this Agreement
so as to cause any of the conditions set forth in Subsection 6.2(a) or Subsection 6.2(b) not to be satisfied.



 




    	 	- 37 -	 



     


    

  


		(iv)	by Cardiome, if:



 


		A.	subject to Section 6.4, Cipher is in default of a covenant or obligation hereunder such that the
condition contained in Subsection 6.3(a) would be incapable of satisfaction, or any representation or warranty of Cipher under
this Agreement is untrue or incorrect or shall have become untrue or incorrect such that the condition contained in Subsection
6.3(b) would be incapable of satisfaction; provided that Cardiome is not then in breach of this Agreement so as to cause any of
the conditions set forth in Subsection 6.3(a) or Subsection 6.3(b) not to be satisfied; or



 


		B.	at any time prior to receipt of the Cardiome Shareholder Approval, Cardiome wishes to enter into
a definitive agreement with respect to a Superior Proposal (other than a confidentiality and standstill agreement permitted by
Section 7.2), subject to, and in compliance with, Section 7.3.



 


		(b)	The Party desiring to terminate this Agreement pursuant to this Section 8.2 (other than pursuant
to Subsection 8.2(a)(i)) shall give notice of such termination to the other Parties, specifying in reasonable detail the basis
for such Party’s exercise of its termination right.



 


		(c)	If this Agreement is terminated pursuant to this Section 8.2, this Agreement shall become
void and be of no further force or effect without Liability of any Party (or any shareholder, director, officer, employee, agent,
consultant or representative of such Party) to any other Party hereto, except that the provisions of Section 7.5, this Subsection
8.2(c) and Sections 8.3, 8.4, 8.5, 10.1, 10.2, 10.3, 10.4, 10.6, 10.7 and 10.8 and all related definitions set forth in Section 1.1
and the provisions of the Confidentiality Agreement shall survive any termination of this Agreement; provided further that neither
the termination of this Agreement nor anything contained in this Section 8.2 shall relieve a Party from any Liability arising prior
to such termination.



 


		8.3	Expenses



 


Except as otherwise provided
herein, the Parties agree that all costs and expenses of the Parties relating to the Arrangement and the transactions contemplated
in this Agreement, including legal fees, accounting fees, financial advisory fees, strategic advisory fees, regulatory filing fees,
stock exchange fees, all disbursements of advisors and printing and mailing costs, shall be paid by the Party incurring such expenses.
For greater certainty, any such costs or expenses of Cardiome shall not form part of the Retained Liabilities.


 


		8.4	Termination Payments



 


		(a)	A Termination Payment shall be payable by Cardiome to Cipher in the event that the Agreement is
terminated in the following circumstances (each being a “Termination Payment Event”):



 


		(i)	the termination of this Agreement pursuant to Subsection 8.2(a)(iii)A, 8.2(a)(iii)B or 8.2(a)(iii)C,
in which case the Termination Fee shall be paid to Cipher as soon as practicable and in any event within two (2) Business Days
of the day on which this Agreement is terminated;



 


		(ii)	the termination of this Arrangement Agreement pursuant to Subsection 8.2(a)(iv)B, in which case
the Termination Fee shall be paid to Cipher prior to or concurrently with termination of this Agreement; or



 




    	 	- 38 -	 



     


    

  


		(iii)	the termination of this Agreement pursuant to Subsection 8.2(a)(ii)A or 8.2(a)(ii)C if, in either
case, prior to the earlier of the termination of this Agreement or the holding of the Cardiome Meeting, (A) a bona fide Acquisition
Proposal, or the intention to make an Acquisition Proposal, with respect to Cardiome shall have been made to Cardiome or publicly
announced by any Person (other than Cipher or any of its affiliates) and not withdrawn prior to the Cardiome Meeting, and (B) within
nine (9) months after the date of termination of this Agreement or the holding of the Cardiome Meeting either (x) such Acquisition
Proposal has been accepted, recommended or approved by the Cardiome Board and has not expired, been withdrawn or been publicly
abandoned, or (y) any Person or company acquires, directly or indirectly, more than 50% of the issued and outstanding Cardiome
Shares or more than 50% of the consolidated assets of Cardiome under such Acquisition Proposal, in which case the Termination Fee
shall be paid to Cipher on the date the Cardiome Shares or assets of Cardiome are acquired as described in paragraph (y) above.
For the purpose of this Subsection 8.4(b)(iii), the term "Acquisition Proposal" shall have the meaning ascribed to such
term in Section 1.1, except that references to "20%" shall be deemed to be "50%".



 


		(b)	Cipher hereby acknowledges that the Termination Payment to which it may become entitled to is a
payment of liquidated damages which is a genuine pre-estimate of the damages which such it will suffer or incur as a result of
the event giving rise to such damages and the resultant non-completion of the Arrangement and the transactions contemplated by
this Agreement and is not a penalty. Cipher hereby irrevocably waives any right it may have to raise as a defence that any such
liquidated damages are excessive or punitive. Upon receipt by Cipher of any Termination Payment, Cipher shall have no further Claim
against Cardiome or Correvio at Law or in equity or otherwise (including injunctive relief to restrain any breach or threatened
breach by Cardiome of any of its obligations hereunder or otherwise to obtain specific performance).



 


		8.5	Termination Payment to Cardiome



 


		(a)	In the event that Cardiome terminates this Agreement pursuant to Subsection 8.2(a)(iv)A of this
Agreement, then Cipher shall pay to Cardiome $2,500,000 (the “Cardiome Termination Fee”) within two (2) Business
Days of the day on which this Agreement is terminated.



 


		(b)	Cardiome hereby acknowledges that the Cipher Termination Payment to which it may become entitled
to is a payment of liquidated damages which is a genuine pre-estimate of the damages which such it will suffer or incur as a result
of the event giving rise to such damages and the resultant non-completion of the Arrangement and the transactions contemplated
by this Agreement and is not a penalty. Cardiome hereby irrevocably waives any right it may have to raise as a defence that any
such liquidated damages are excessive or punitive. Upon receipt by Cardiome of any Cipher Termination Payment, Cardiome shall have
no further Claim against Cipher at Law or in equity or otherwise (including injunctive relief to restrain any breach or threatened
breach by Cipher of any of its obligations hereunder or otherwise to obtain specific performance).



 


		8.6	Amendment



 


Subject to the provisions of the Interim
Order and Final Order, the Plan of Arrangement and applicable Laws, this Agreement and the Plan of Arrangement may, at any time
and from time to time prior to the Effective Time, be amended only by mutual written agreement of Cipher and Cardiome, without
further notice to or authorization on the part of the Cardiome Shareholders, and any such amendment may without limitation:


 


		(a)	change the time for performance of any of the obligations or acts of the Parties;



 


		(b)	waive any inaccuracies or modify any representation or warranty contained herein or in any document
delivered pursuant hereto;



 




    	 	- 39 -	 



     


    

  


		(c)	waive compliance with or modify any of the covenants herein contained and waive or modify performance
of any of the obligations of the Parties; and



 


		(d)	waive compliance with or modify any mutual conditions precedent herein contained.



 


		8.7	Waiver



 


Any Party may (a) extend the time for the
performance of any of the obligations or acts of the other Party, (b) waive compliance, except as provided herein, with any of
the other Party’s agreements or the fulfilment of any conditions to its own obligations contained herein, or (c) waive inaccuracies
in any of the other Party’s representations or warranties contained herein or in any document delivered by the other Party,
in each case only to the extent such obligations, agreements and conditions are intended for its benefit. No extension or waiver
shall be valid unless set forth in an instrument in writing signed on behalf of such Party and, unless otherwise provided in the
written waiver, will be limited to the specific breach or condition waived and shall not extent to any other matter or occurrence.
No failure or delay in exercising any right, power or privilege under this Agreement will operate as a waiver thereof, nor will
any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any right, power or privilege
under this Agreement.


 


Article
9

INDEMNITY AND WARRANTY


 


		9.1	Correvio Indemnity



 


		(a)	From and after the Effective Time, Correvio shall indemnify and save harmless Cipher and its subsidiaries
and Cardiome and their respective directors, officers, employees and agents (the “Cipher Indemnified Parties”)
in respect of any Claim, including relating to Taxes, and from and against any and all Losses arising in connection with or relating
in any manner to:



 


		(i)	the Retained Assets or Retained Liabilities, in respect of the period prior to the Effective Time;



 


		(ii)	the Assigned Assets;



 


		(iii)	the Assumed Liabilities;



 


		(iv)	the Employee Obligations;



 


		(v)	all Contracts relating to the Assigned Assets, Assigned Liabilities or Employee Obligations;



 


		(vi)	the business or operations of Cardiome or its subsidiaries in respect of the period prior to the
Effective Time, including any product liability claims in respect of products developed or commercialized by Cardiome or its subsidiaries;



 


		(vii)	the carrying out or implementation of the Pre-Closing Reorganization or the transactions contemplated
by the Arrangement;



 


		(viii)	the exercise of any Dissent Rights by Dissenting Shareholders; or



 


		(ix)	all Taxes payable by Cardiome with respect to all periods ending on or before the Effective Date
(including those arising as a result of the carrying out or implementation of the transactions contemplated by this Agreement,
including the Arrangement).



 




    	 	- 40 -	 



     


    

  


		(b)	The obligations of Correvio under Subsection 9.1(a) shall survive the execution and delivery of
this Agreement and the completion of the transactions contemplated by this Agreement, including the Arrangement, provided that:



 


		(i)	if a Claim or Loss relates to Subsection 9.1(a)(i), the obligations of Correvio shall survive for
a period of two (2) years following the Effective Date and, provided further that: (A) no Losses may be recovered from Correvio
pursuant to Subsection 9(a)(i) unless and until the accumulated aggregate amount of Losses of Cipher Indemnified Parties arising
pursuant thereto exceeds $200,000, in which event the accumulated aggregate amount of all such Losses may be recovered; and (B)
Correvio shall not be liable for any Losses pursuant to Subsection 9(a)(i) in excess of $3,000,000;



 


		(ii)	if a Claim or Loss relates to any of Subsection 9.1(a)(ii) to Subsection 9.1(a)(viii), inclusive,
the obligations of Correvio shall survive until expiration of any limitation periods imposed by Law applicable to the subject matter
of the Claim or Loss; or



 


		(iii)	if a Claim or Loss relates to Subsection 9.1(a)(ix), the obligations of Correvio shall survive
until one year after the expiration of any limitation periods imposed by Law applicable to the relevant taxation year (giving effect
to any waiver, mitigation or extension thereof).



 


		(c)	The rights to indemnification of the Cipher Indemnified Parties under Section 9.1(a) shall apply
notwithstanding any investigation, inspection or inquiries made by or on behalf of any of the Cipher Indemnified Parties.



 


		9.2	Cipher Indemnity



 


		(a)	From and after the Effective Time, Cipher shall indemnify and save harmless Correvio and its subsidiaries
and their respective directors, officers, employees and agents (the “Correvio Indemnified Parties”) in respect
of any Claim, and from and against any and all Losses, arising in connection with or relating in any manner to:



 


		(i)	the Retained Assets, in respect of the period following the Effective Time; or



 


		(ii)	the Retained Liabilities, in respect of the period following the Effective Time.



 


		(b)	The obligations of Cipher in under Subsection 9.2(a) shall survive the execution and delivery of
this Agreement and the completion of the transactions contemplated by this Agreement, including the Arrangement, until expiration
of any limitation periods imposed by Law applicable to the subject matter of the Claim or Loss.



 


		(c)	The rights to indemnification of the Correvio Indemnified Parties under Section 9.2(a) shall apply
notwithstanding any investigation, inspection or inquiries made by or on behalf of any of the Correvio Indemnified Parties.



 


		9.3	Taxable Gain Warranty



 


		(a)	Correvio warrants to Cipher that the aggregate amount of (i) income in excess of losses, and (ii)
taxable capital gains in excess of allowable capital losses, in all cases realized by Cardiome as a result of the transactions
contemplated in this Agreement, including the Arrangement, will not exceed $1,000,000.



 


		(b)	The warranty of Correvio under Subsection 9.3(a) shall survive the execution and delivery of this
Agreement and the completion of the transactions contemplated by this Agreement, including the Arrangement, until one year after
the expiration of any limitation periods imposed by Law applicable to the relevant taxation year (giving effect to any waiver,
mitigation or extension thereof).



 




    	 	- 41 -	 



     


    

  


		9.4	Claim Notice



 


If an Indemnified Party becomes aware of
any act, omission or state of facts that may give rise to Losses in respect of which a right of indemnification is provided or
a claim for breach of warranty is permitted for under this Article 9, a Party entitled to and seeking indemnification pursuant
to the terms of this Agreement (the “Indemnified Party”) shall promptly give written notice (a “Claim
Notice”) to the Party responsible for indemnifying the Indemnified Party (the “Indemnifying Party”)
of any claim for indemnification pursuant to Sections 9.1 or 9.2 (an “Indemnification Claim”, which term shall
include more than one Indemnification Claim) or a claim for damages for breach of warranty pursuant to Section 9.3 (a “Damages
Claim”). The Claim Notice shall specify whether Indemnification Claim or Damages Claim arises as a result of a claim
by a Person against the Indemnified Party (a “Third Party Claim”) or whether the Indemnification Claim arises
as a result of a claim directly by the Indemnified Party against the Indemnifying Party (a “Direct Claim”),
and shall also specify with reasonable particularity (to the extent that the information is available):


 


		(a)	the factual basis for the Direct Claim or Third Party Claim, as the case may be; and



 


		(b)	the amount of the potential Damages Claim (“Damages”) or Losses arising from
the Indemnification Claim, if known.



 


If, through the fault of the Indemnified
Party, the Indemnifying Party does not receive a Claim Notice in time effectively to contest the determination of any Liability
susceptible of being contested or to assert a right to recover an amount under applicable insurance coverage, then the liability
of the Indemnifying Party to the Indemnified Party under this Article 9 shall be reduced to the extent that Losses or Damages are
incurred by the Indemnifying Party resulting from the Indemnified Party’s failure to give the Claim Notice on a timely basis.


 


		9.5	Agency for Non-Parties



 


Each Party hereby accepts
each indemnity in favour of each of its Indemnified Parties who are not Parties as agent and trustee of that Indemnified Party.
Each Party may enforce an indemnity in favour of any of that Party’s Indemnified Parties on behalf of each such Indemnified
Party.


 


		9.6	Procedure for Indemnification – Direct Claims



 


In the case of a Direct
Claim, the Indemnifying Party shall have 45 days from receipt of a Claim Notice to make such investigation as the Indemnifying
Party considers necessary or desirable. For the purpose of such investigation, the Indemnified Party shall make available to the
Indemnifying Party the information relied upon by the Indemnified Party to substantiate its Indemnification Claim, together with
all such other information as the Indemnifying Party may reasonably request. If the Indemnified Party and the Indemnifying Party
agree at or prior to the expiration of such 45 day period (or any mutually agreed upon extension thereof) to the validity and amount
of such Indemnification Claim, the Indemnifying Party shall immediately pay to the Indemnified Party the full agreed upon amount
of the Indemnification Claim. If the Indemnified Party and the Indemnifying Party fail to agree at or before the expiration of
such 45 day period (or any mutually agreed upon extension thereof), the Indemnified Party shall be free to pursue all remedies
as may be available to it.


 


		9.7	Procedure for Indemnification – Third Party Claims



 


		(a)	In the case of a Third Party Claim, the Indemnifying Party shall have the right, at its expense,
to control the negotiation, settlement or defence of the Third Party Claim, through counsel of its choice (such counsel to be acceptable
to the Indemnified Party, acting reasonably); provided, however, that notwithstanding the foregoing, the Indemnifying Party shall
not be permitted to assume control of the negotiation, settlement or defence of the Third Party Claim if such Third Party Claim
involves criminal liability.



 




    	 	- 42 -	 



     


    

  


		(b)	If the Indemnifying Party elects to assume control as contemplated in Subsection 9.9(a), the
Indemnifying Party shall reimburse the Indemnified Party for all of the Indemnified Party’s out-of-pocket expenses incurred
as a result of such assumption. The Indemnified Party shall continue to have the right to participate in the negotiation, settlement
or defence of such Third Party Claim and to retain counsel to act on its behalf, provided that the fees and disbursements of such
counsel shall be paid by the Indemnified Party unless the Indemnifying Party consents to the retention of such counsel at its expense
or unless the named parties to any action or proceeding include both the Indemnifying Party and the Indemnified Party and the representation
of both the Indemnifying Party and the Indemnified Party by the same counsel would be inappropriate due to the actual or potential
differing interests between them (such as the availability of different defences), in which case the fees and disbursements of
such counsel of the Indemnified Party shall be paid by the Indemnifying Party. The Indemnified Party shall co-operate with the
Indemnifying Party so as to permit the Indemnifying Party to conduct and control such negotiation, settlement and defence and for
this purpose shall preserve all relevant documents in relation to the Third Party Claim, allow the Indemnifying Party access on
reasonable notice to inspect and take copies of all such documents and require its personnel to provide such statements as the
Indemnifying Party may reasonably require and to attend and give evidence at any trial or hearing in respect of the Third Party
Claim. If the Indemnifying Party, having elected to assume such control, thereafter fails to defend any such Third Party Claim
within a reasonable time, the Indemnified Party shall be entitled to assume such control and the Indemnifying Party shall be bound
by the results obtained by the Indemnified Party with respect to such Third Party Claim.



 


		(c)	If the Indemnifying Party assumes the defence of a Third Party Claim, it shall be deemed to have
acknowledged its obligation to indemnify and hold the Indemnified Party harmless with respect to such Third Party Claim.



 


		(d)	If any Third Party Claim is of a nature such that the Indemnified Party is required by applicable
Law to make a payment to any Person (a “Third Party”) with respect to such Third Party Claim before the completion
of settlement negotiations or related legal proceedings, the Indemnified Party may make such payment and the Indemnifying Party
shall, forthwith after demand by the Indemnified Party, reimburse the Indemnified Party for any such payment. If the amount of
any Losses of the Indemnified Party under the Third Party Claim in respect of which such a payment was made, as finally determined,
is less than the amount which was paid by the Indemnifying Party to the Indemnified Party, the Indemnified Party shall, forthwith
after receipt of the difference from the Third Party, pay the amount of such difference to the Indemnifying Party with interest
at the then current Court Order Interest Act rate.



 


		(e)	The Indemnifying Party shall not settle any Third Party Claim or conduct any related legal or administrative
proceeding in a manner which would, in the opinion of the Indemnified Party, acting reasonably, have a material adverse impact
on the Indemnified Party.



 


		9.8	Cooperation



 


Each Indemnified Party
and Indemnifying Party shall reasonably cooperate and assist each other in determining the validity of any Indemnification Claim
by an Indemnified Party and otherwise in resolving such matters. Such assistance and cooperation will include providing reasonable
access to information, records and documents relating to such matters and furnishing employees to assist in the investigation,
defence and resolution of such matters.


 




    	 	- 43 -	 



     


    

  


		9.9	Holdback Amount



 


		(a)	To the extent that a Cipher Indemnified Party is entitled to Losses arising from an Indemnification
Claim or Damages arising from a Damages Claim pursuant to this Agreement, then, in addition to any rights of set-off or other rights
that such Cipher Indemnified Party may have at common law or otherwise, Cipher (on behalf of such Cipher Indemnified Party) shall
have the right to set-off any Losses or Damages to which such Cipher Indemnified Party may be entitled to under this Agreement
against the Holdback Amount (on a dollar-for-dollar basis), provided that: (i) in the event a Cipher Indemnified Party is required
to satisfy any such Losses with an out-of-pocket cash payment to any Third Party, Cipher (on behalf of such Cipher Indemnified
Party) may, in its sole discretion, require that Correvio satisfy any indemnification obligations hereunder relating to such Losses
in cash; and (ii) if the aggregate amount of any Losses in respect of Indemnification Claims or Damages in respect of a Damages
Claim exceeds the Holdback Amount, Correvio shall be required to satisfy all such amounts in excess of the Holdback Amount in cash.



 


		(b)	Notwithstanding the foregoing, and without in any manner limiting the rights of indemnification
in favour of the Cipher Indemnified Parties under this Article 9, Cipher shall pay to Correvio the Holdback Amount, as follows:



 


		(i)	twenty-five percent (25%) of the Holdback Amount on the date that is three (3) months following
the Effective Date,



 


		(ii)	twenty-five percent (25%) of the Holdback Amount on the date that is six (6) months following the
Effective Date,



 


		(iii)	twenty-five percent (25%) of the Holdback Amount on the date that is nine (9) months following
the Effective Date, and



 


		(iv)	twenty-five percent (25%) of the Holdback Amount on the date that is twelve (12) months following
the Effective Date,



 


less, in each
case, any amounts that are permitted to be deducted from, and subject to set-off against, the Holdback Amount pursuant to Subsection
9.9(a), as at each respective payment date.


 


		9.10	Exclusive Remedy



 


After the Effective Date,
the rights of the Parties hereto and the Indemnified Parties to indemnification relating to this Agreement or the transactions
shall be strictly limited to those contained in this Article 9, and such indemnification rights shall be sole and exclusive remedies
of the Parties hereto and the Indemnified Parties subsequent to the Effective Date with respect to any matter in any way relating
to this Agreement or its subject or arising in connection herewith. Except as provided in this Article 9, no Claim shall be brought
or maintained by any Party against any other Party, and no recourse be brought or granted against any of them, by virtue of or
based upon any alleged misstatement or omission respecting an inaccuracy in or breach of any of the representations, warranties,
or agreements of any of the Parties hereto set forth or contained in this Agreement.
Notwithstanding the foregoing, nothing in this Agreement shall limit any Party’s remedies against another Party for fraud,
willful misconduct, fraudulent misrepresentation or intentional misrepresentation.


 


		9.11	No Double Recovery



 


An Indemnifying Party
shall not be liable under any Indemnification Claim to the extent that the Losses that are the subject of the relevant Indemnification
Claim have already been recovered in respect of another Indemnification Claim.


 




    	 	- 44 -	 



     


    

  


		9.12	Price Purchase Consideration Adjustment



 


To the extent permitted pursuant to applicable
Laws, all payments made by or on behalf of an Indemnifying Party to an Indemnified Party in respect of any Indemnification Claim
pursuant to this Article 9 shall be treated as adjustments to the Share Purchase Consideration for Tax purposes.


 


Article
10

GENERAL PROVISIONS AND MISCELLANEOUS


 


		10.1	Privacy



 


Each Party shall comply with applicable
privacy Laws in the course of collecting, using and disclosing personal information about identifiable individuals in connection
with the transactions contemplated hereby (the “Transaction Personal Information”). Neither Party shall disclose
Transaction Personal Information originally collected by the other Party to any Person other than to its advisors who are evaluating
and advising on the transactions contemplated by this Agreement. If Cipher completes the transactions contemplated by this Agreement,
Cipher shall not, following the Effective Date, without the consent of the individuals to whom such Transaction Personal Information
relates or as permitted or required by applicable Law, use or disclose Transaction Personal Information originally collected by
Cardiome:


 


		(a)	for purposes other than those for which such Transaction Personal Information was collected by
Cardiome prior to the Effective Date; and



 


		(b)	which does not relate directly to the carrying on of the business of Cardiome or to the carrying
out of the purposes for which the transactions contemplated by this Agreement were implemented.



 


The Parties shall protect and safeguard
the Transaction Personal Information against unauthorized collection, use or disclosure. Cipher shall cause its advisors to observe
the terms of this Section 10.1 and to protect and safeguard all Transaction Personal Information in their possession. If this Agreement
shall be terminated, each Party shall promptly deliver to the other Party all Transaction Personal Information originally collected
by such other Party in its possession or in the possession of any of its advisors, including all copies, reproductions, summaries
or extracts thereof, except, unless prohibited by applicable Law, for electronic backup copies made automatically in accordance
with the usual backup procedures of the Party returning such Transaction Personal Information.


 


		10.2	Notices



 


All notices and other communications given
or made pursuant to this Agreement shall be in writing and shall be deemed to have been duly given and received on the day it is
delivered, provided, however, that it is delivered on a Business Day prior to 4:30 p.m. Vancouver time in the place of delivery
or receipt. However, if notice is delivered after 4:30 p.m. Vancouver time or if such day is not a Business Day then the notice
shall be deemed to have been given and received on the next Business Day. Notice shall be sufficiently given if delivered (either
in Person, by courier service or other personal method of delivery), or if transmitted by email to the Parties at the following
addresses (or at such other addresses as shall be specified by any Party by notice to the other given in accordance with these
provisions):


 


		(a)	if to Cipher:



 


Cipher Pharmaceuticals Inc.


2345 Argentia Road, Suite 100A


Mississauga, Ontario L5N 8K4


 


	Attention:	Robert Tessarolo
	Email:	rtessarolo@cipherpharma.com


 




    	 	- 45 -	 



     


    

  


with a copy (which shall not
constitute notice) to:


 


Wildeboer Dellelce LLP


365 Bay Street, Suite 800


Toronto, ON M5H 2V1


 


	Attention:	James Brown
	Email:	jbrown@wildlaw.ca


 


		(b)	if to Cardiome or Correvio:



 


Cardiome Pharma Corp.


1441 Creekside Drive


6th Floor


Vancouver, British Columbia V6J
4S7


 


	Attention:	Bill Hunter
	Email:	bhunter@cardiome.com


 


with a copy (that shall not constitute
notice) to:


 


Blake, Cassels & Graydon LLP

595 Burrard Street

Suite 2600, Three Bentall Centre

Vancouver BC V7X 1L3


 


	Attention:	Joe Garcia
	Email:	joseph.garcia@blakes.com


 


		10.3	Governing Law



 


This Agreement shall be governed, including
as to validity, interpretation and effect, by the Laws of the Province of British Columbia and the Laws of Canada applicable therein,
without giving effect to any principles of conflict of Laws thereof which would result in the application of the Laws of any other
jurisdiction. Each of the Parties hereby irrevocably attorns to the exclusive jurisdiction of the courts of the Province of British
Columbia in respect of all matters arising under and in relation to this Agreement and the Arrangement.


 


		10.4	Injunctive Relief



 


Subject to Section 8.4 and Section 8.5,
the Parties acknowledge and agree that irreparable harm would occur for which money damages would not be an adequate remedy at
Law in the event that any of the provisions of this Agreement were not performed in accordance with their specific terms or were
otherwise breached. Accordingly, the Parties agree that, in the event of any breach or threatened breach of this Agreement by a
Party, the non-breaching Party will be entitled, without the requirement of posting a bond or other security, to equitable relief,
including injunctive relief and specific performance, and the Parties shall not object to the granting of injunctive or other equitable
relief on the basis that there exists an adequate remedy at Law. Subject to Section 8.4 and Section 8.5, such remedies will not
be the exclusive remedies for any breach of this Agreement but will be in addition to all other remedies available at Law or equity
to each of the Parties.


 


		10.5	Time of Essence



 


Time shall be of the essence in this Agreement.


 




    	 	- 46 -	 



     


    

  


		10.6	Entire Agreement, Binding Effect and Assignment



 


This Agreement (including the exhibits
and schedules hereto and the Cardiome Disclosure Letter) and the Confidentiality Agreement constitute the entire agreement, and
supersede all other prior agreements and understandings, both written and oral, among the Parties, or any of them, with respect
to the subject matter hereof and thereof and, except as expressly provided herein, this Agreement is not intended to and shall
not confer upon any Person other than the Parties any rights or remedies hereunder. This Agreement shall enure to the benefit of
and be binding upon the Parties and their respective successors and permitted assigns. Neither this Agreement nor any of the rights,
interests or obligations hereunder may be assigned by any of the Parties without the prior written consent of the other Parties.


 


		10.7	No Liability



 


No director or officer of Cipher shall
have any personal liability whatsoever to Cardiome under this Agreement, or any other document delivered in connection with the
transactions contemplated hereby on behalf of Cipher. No director or officer of Cardiome shall have any personal liability whatsoever
to Cipher under this Agreement, or any other document delivered in connection with the transactions contemplated hereby on behalf
of Cardiome.


 


		10.8	Severability



 


If any term or other provision of this
Agreement is invalid, illegal or incapable of being enforced by any rule or Law or public policy, all other conditions and provisions
of this Agreement shall nevertheless remain in full force and effect so long as the economic or legal substance of the transactions
contemplated hereby is not affected in any manner materially adverse to any Party. Upon such determination that any term or other
provision is invalid, illegal or incapable of being enforced, the Parties shall negotiate in good faith to modify this Agreement
so as to effect the original intent of the Parties as closely as possible in an acceptable manner to the end that the transactions
contemplated hereby are fulfilled to the fullest extent possible.


 


		10.9	Counterparts, Execution



 


This Agreement may be executed in one or
more counterparts, each of which shall be deemed to be an original but all of which together shall constitute one and the same
instrument. The Parties shall be entitled to rely upon delivery of an executed facsimile or similar executed electronic copy of
this Agreement, and such facsimile or similar executed electronic copy shall be legally effective to create a valid and binding
agreement among the Parties.


 


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blank]


 




    	 	- 47 -	 



     


    

  


IN WITNESS WHEREOF the Parties have executed
this Arrangement Agreement as of the date first written above by their respective officers thereunto duly authorized.


 


	 	CIPHER PHARMACEUTICALS INC.
	 	 
	 	Per:	 
	 	 	Name:  Robert Tessarolo
	 	 	Title:   President and CEO
	 	 	 
	 	CARDIOME PHARMA CORP.
	 	 
	 	Per:	 
	 	 	Name:  William Hunter
	 	 	Title:    President and CEO
	 	 	 
	 	CORREVIO PHARMA CORP.
	 	 
	 	Per:	 
	 	 	Name:  William Hunter
	 	 	Title:    President and CEO


 


Signature Page
to Arrangement Agreement