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X 1 N N ^~ h7 >C ~' 1' rT1 X 1 ^' h' SU h7 X I f ~ }~ ~' h7 ~~ I I~ I~ ~~~ ~~I I I~II ~ ~~ ~~ I I I ~I~ 1=~~~ ► ~I 1 1~1~ ~~ :

4-

XI N N N ~ X I N N N y] X 1 N N N ~'rf

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H

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~I I I~IWI~I n leiI I l~l Vp l

%pi l

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~

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O I II~j IQ- n n n

%

' ~ ~

n w ~ I I I I v ► ~ ~

DAY 8 : POST-BCC DAY 7 : POST-BCC DAY6 : POST-BCC DAY 5 : POST-BC C

169 111 ~~l~il~~ n iX I I I I I R -0 1 1 1 1 1 1

~

51 I

n n w 131 x ~bpi I

~ ~ I_I~1 I ~ ~ I~ I i I I~0 n n

to!

~

~ a ~ ~ ~ ~ A ► ~
• ~ p. 40

DAY 4 : PRE-TEST DAY 3 : PRE-TEST DAY 2 : PRE-TEST LDAY 1 : PRE-TES T

Cr<

t

-"J

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XI ~jj x i

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DAY 4 : REST Ir 1 L

DAY 3 : REST T 1 DAY 2 : REST T1 DAY 1 : REST u1

s

x,

r

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I {

D Y REST #3 DAY 3 : REST 4 3 DAY 2 : REST s 3 DAY 1 : REST ' : 3

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xl

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~ .~

°

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~

Fv~ ~ ~ n n

4-1

DAY 4 : POST-BCC DAY 3 : POST-BCC DAY 2 : POST-BCC DAY 1 : POST-BCC

~III ► x II~~~Xlil~i ~ ~Xc X ~X x

~- I I ~~{{ I~n I~ I I I I'I I I I I

~~~ ~mc~

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r

v~~ x

rLI

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k ~orro

. ,
~ p.41

DAY g : PRE-TEST DAY 7 : PRE-TEST DAY ??ZZ.-TEST DAY 5 . : PRE-TEST

CI I ~W . . co

=,

0 ~~ o

X1 N` nf N ~~j ^' Tl X I N l,~ N N c" T~ X I (~ ~~j t1a C~ ~"7 \ N 7~ 1~ 7~i ~rj

{` IC I~ n J ~ I Q I N ~~ n

DAY 8: REST ,ur 1 DAY 7 : REST ~ 1 DAY 6 : REST ,ur 1 DAY 5 : REST # 1

X t -A a °~ -~ C!~ X I ~~~ r U]C X I b~ C!)C x t on at w V]

I'~ I `' I w I~ I aO I ~ I a I ~~ I'~ I~0 I w I w (~ I'OI ~'' I°O I F

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I~(°c c~ I °~ ~ ` I~ I N I .,~ I-~ u' ( w If I" I~I I I" \ I~'t~ I w "'

DAY g : REST -lur 3 DAY 7 : REST ~ 3 DAY 6 : REST 1# 3 DAY 5: REST # 3

X p i,, -A [AC ~C 1 -u -0 G)r x Cl1C X t -O -d CA

~wl I~IN ~ CP% I I~I (A IwI~ 'n ~I

-~~~ ~

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I ~I°Q IC I~t I'Q IN IN I Q IvJ IC t _ I 1C IC~Iw N W~~ C

IN I IN n ~ ~ I{v~ n ~ Vr

V

.+ F v~ °~ r' ~

DAY 8 : PRE-BCC DAY 7 : PRE-BCC DAY PRE-BCC DAY 5: PRE-BC C

X I ` _ ~ h7 X I (~ U ~ `~1 X t W ~Ja "T1 t ~ ~`l3 ~ !

Io~ ( ~ n< Lr' ~

DAY 8 : POST-BCC DAY 7 : POST-BCC DAY6 : POST-BCC DAY 5 : POST-BC C

A

x x x !

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w

t x ~t~'h ~ eR~~ ,e . !lic x wtyx u~~o'~ 4i ~ m~VJ4~~ w

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p.42

DAY 8 : PRE-TEST DAY 7 : PRE-TEST DAY 6. : ?R✓ -TEST DAY 5 . : PRE-TES T

~n

~~,

~~~ a~ i ~ i xl I ( J~}~ ~ri ~

< n n< In<

DAY 8: REST n 1 DAY 7 : REST n 1 DAY 6 : REST 71 DAY 5 : REST T 1

6~ S N~ I ~l:*.

I"'' f I N l N~, C ~" I I I ~' oo~ ~C I r' l ~~ r+ C X' ~, _ N C

~ I ~, N N h] X 1 4J ' ~~T7 X I n. IJ !~ h7 I

JIJ (~IJOIn N n

DAY 8: REST # 3 DAY 7 : REST n 3 DAY 6 : REST n 3 DAY 5: REST * 3

U

mrJ>"

~

~ ~. J o Iwl l wl~ I . zi:

X I N N / h1 XI 7~ h7 X 1 N~1 N

V\ ~ IIII~ ~11~1 ~

X I N 1" hy X ~~ T] X 1 t" N t~+ rz~ 1 ~TJ

II~I~I~I n

lldl; ~ lll INI~r ~ VI I I~ } I

DAY 8 : PRE-BCC DAY 7 : PRE-BCC DAY PRE-BCC DAY 5: PRE-BCC

' Q~ Q1 t ~,I P",

n (]VJ i JI~ ~U n

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~ NI I ~~,I I ~ X X ~ X X ~ X

.~ I J I I ~ JJ i~e~iii~~~~il~w

<

► ~ I~~c~l I~I~I~ ~ ~~ X ~ ~ ~ ~

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I ~

Y w In I` (~l Ci~ ~ iJl3kr~in I-i ~~ ~ ij %N

In ~I J°q a, n

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~► p. 43

. " 4 : PRE-TEST DAY 3 : PRE-TEST L

DAY 2 : PRE-TEST (-DAY 1 : PRE-TEST '

Cj)

°~ X 1 ~~•- . 1

~-A

~,

_ - , I~I~ JI~~I~ IIJ J~ ~~_► ~ ~►~,

_ v C x I 1 ~ L LJ C

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DAY 4 : REST 14 1 I DAY 3 : REST ; 1 + DA_ 2 : REST T# 1 DAY 1 : REST 2 1

~ cnC X, cr)-- xi

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DAY 4 : REST 4 3 (DAY 3 : REST T 3 DAY 2 : REST T3 DAY 1 : REST 73

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C)

cr I~

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DAY 4 : PRE-BCC tDAY 3 : PRE-BCC DAY 2 : PRE-BCC DAY 1 : PRE-BCC

X,

Ml ~ V 9J ~ L1 h x, ~, R, c

Ily I~I~~

~~ I IIIII ~ I ~

N

DAY 4 : POST-BCC DAY 3 : POST-BCC DAY 2 : POST-BCC DAY 1 : POST-BCC

I•< I I I I X l I I X X >C X [r~ X G I I ~t- ~ J=~III~I1 IJ IIIrIIIIJ~III ~ '

Al ~

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p. 44

DAY PRE-TEST DAY PRE-TEST DAY 61

: ??Z.-TEST L

DAY 5 . : P RE-TEST

XI

I-dI~INI~ ~n '6~ -0 '.. w ~

x, w w u' ti7 x, w w t^' ~7 x, w w u' ~ x, ~

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x, w w w~7 x, ~ w w~1 x, w w w z] ><t

DAY 8: REST tt 1 DAY 7: REST n l DAY 6 : REST tt 1 DAY 5 : REST 7# 1

Ut ~n

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i

x, ~

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H

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v, w

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I~ I I I XI I I ~ X X X IxI -I I I 'XI I ~ ~~-~I A IG~I~I-I~~~.~~ ~

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x x -

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c x x ~ x x c ~

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p. 45

mom

DAY 4 : PRE-TEST DAY 3 : PRE-TEST DAY 2 : PRE-TEST (

DAY 1 : PRE-TES T

() ~I 'xi

cn< x,

r 6' I-C ~

1-y.' h ~• II~? ~1~~ " ~ ► C~J I~l C _ Y' 7"- 1,(~ C n r~ I'~1 C ( v I C r

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DAY 4•: REST Y 1 LDAY 3 : REST T 1 ( DAY 2 : REST T 1 DAY l : REST T1

w~ C V~► ~~~ W C ~ 1fV ~ l1~ r i >C1 ~}J Gj C1~ '7

DAY 4 : REST T 3 (DAY 3 : REST 7 3 I DAY 2 : REST T 3 'DAY 1 : REST r 3

x, W cr~ x, 6~_ UK %I (,~ U cr)--

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C

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r- -t x ~~~ '7 xl

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l-, a

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p. 46

DAY PRE-TEST DAY PRE-TEST DAY 6; : _-_3R:.-TEST DAY 5 . : PRE-TEST

'

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CK)

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1-,~sr~~ _41

DAY 8: REST # 1 DAY 7 : REST # 1 DA 6 : REST - 1 DAY 5 : REST n 1

FiI~~I r I I Iwl I I,I

9Q c N~ '' ~' c N c

~ NINF-~I

DAY 8 : REST TIIr 3 DAY 7 : REST IT' 3 DAY 6 : REST It 3 DAY 5: REST # 3

r 1-14, 1 1 ~ ~

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Ic

001 J

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p. 47

LIPRE:TEST DAY 3 : PRE-TEST DAY 2 : PBE-TEST DAY 1 : PR ~~'-T E

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a- ~ ST

t ~ R

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DAY 4 : REST 1 DAY 3 : REST 7 1 DA_ 2- ,ST T DAY 1 : REST 71

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DAY 4 : REST 41 3 ,DAY 3 : REST ',`3 DAY 2

.~ ~

: REST R3 'DAY 1 : REST -imr 3

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X 1

I f r

Q- , I~II~I lo~ ~ ~

~~~ i I IW ~ I i I I I~I n n

DAY 4 : POST-ECC DAY 3 : POST-BCC DAY 2 : POST-BCC DAY 1 : POST-BCC

X ~ I I x I I I ~ x x ~ x X ~ X

x

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~ p. 48

DAY g : PRE-TEST DAY 7 : PRE-TEST DAY 6, : ?R=.-TEST DAY 5 : PRE-TEST

F lz l Is,

x 1 N "' 'T~ X, N lJ ~~1 '"7 x I ^ ►'~ ^ 'TJ X

77

rrf

4gi( 0

~n r' o w C c7 6` ( lp n I`~( ( G G G 1G ~

DAY 8: REST n 1 DAY 7 : REST ir 1 DAY 6 REST it 1 DAY 5 : REST n 1

x, ~~° X1 I ~ :-

l

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X 1 w w w ~ X, n+ / ~ " "7 XI X1 ~ 4~N

DAY 8 : REST If 3 DAY 7: REST #3 DAY 6 : REST ~ 3 JDAY 5: REST ur, 3

~I 1sl~i~l~l~ w`~ ~~`~ c Col I ' I~I:"~ I~I~;

p p r

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.

,

v l~. ~~ x1 ~ x1 '~ Is ~ (~ I i~I l I I~

DAY 8 : POST-BCC DAY 7 : POST-BCC DAY6 : POST-BCC DAY 5 : POST-BCC

x x x ~ x x ~ x x

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J - - - - - - - p.49

r4 rt ~

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a ~ }~ o ~9 C` m ~.

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w X f- ~

~

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DDS -ssoa = T 2~V a DD g-ssod ~z -T,V a oD a-ssoa = E 2~V a oos-ssoa =~ .7,vQ

C- C- ~ rr )

rn`

1 ! ~x ~-~'~ -~ . ~X ~► ~I M(~{ 1 ! ~x ~1 rnl m ~ r

X

nvQ 3 DY?a ~Z nYQ JJS-a-~id =E 2~dQ SJE-S nd ~v 2~-e Q

Ki

a- 1-5 i x

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_~I i -! ~ {~1 ~{~{ ~I~~~ M ~ I v- _ ,_ 1 {► Ix~ ~1~ ~l~ !~ ~ ~~,~ 1~ ~ ~

E n SS31d = T 2MI E T Z S32i = Z Ave ~ Z T J S32i = E 'wQ I E; ZS----3 nFia

- ~ -! '► ~' ~ { M1 M ! ! ( XI 'f ~{~ - ~ ~I m ~ ~ j ~~ rD c~

4 ~ ~~{~~ I7C L~~ N f fY { N ! 1 1 x Ll ~~' n~ I?C C~ I O 1 ~{ cd 1~G

~~ ~ ~ ~. . ~ •~ _ ~ ~' • 3 ~ • 1 ~ 4- o` ^r~I

ri,: I ~{~1 { ~ lod ► ~~ ~ ~ _~ f i l,l; ~ x4

! ~ n ZS 32i = T n'da T n 133~i Z3 32i : Z 7,,`da T ZS32i nKQ

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,

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44

tt-q !

~ ~ ~ w ► rr>-ctJ' ~~ ! 1 ~1 `U ~

j W o Q- cr ~ I

Ix Ix

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` ~S3Z-32id =1 n dQ ZSa LI,- =-ha ~ Z ;~ `dQ I S3i-3~d ~Fta S3? 323d 2~ V Cl

~
p.50

~ ~ 88 s 4~~1y ~- ~ -

C' t5 8 7 Sa~- S 1J"r ~ A4 PC T

APoE-NpIX

SPECIFIC AIRWAY RESIS"'NCE DATA FOR INDIVIDUAL SURTECTS

A printout of individual S'Ra' w data from every test session is reproduced

on the following pages . Each case number ( left column on each page)

corresponds to one individual, lidentified by the subject number ( SI3BN0, second

column on first page) given in the body of the renort . Each observation of

5'Raw (CB) is identified by a nu7eric3l suf=ix, in which the first digit

indicates the exposure/pretreat: ent condition and the second digit indicates

the tire of masure:m nt, as follows .

First digit : 1= 0 .0 ppm 302, untreated ; 2 = 0 .0 porn, placebo ; 3

0 .0 pom, drug ; 4 = 0 .3 ppm, untreated ; 5 0 .3 ppm, placebo ; 6= 0 .3 ppm, drug ;

7 = 0 .6 ppm, untreated ; S= 0 .6 --cm, placebo ; 9 = 0 .6opm, drug .

Second digit : 1= baseline Treasure*nen t ; 2 = after pretreatment ( before

exposure) ; 3= im ~ - -mdiatelv after e:ccosure ; a= 30 min after ; 5 = 1 hr after ;

6= 90 min after ; 7 = 2 hr after .

Dots be tween entries indicate elective use of a bronchodilator between the

two test sessions .

4
p. 51

I O O O O O O O O O O O O a O O O a o O O O O O O O O O O O O O O o O O O O O C O

1 O O O^ O O~ O O O O e V C O f O O O O I O I O O O O O O O O O O O O O O O O O O O O

m vi N r m~ T~O b O O r~D N! m O a• ! a 1 ~ n ~O ••. N m N Pf f . + O O, m-O r Ot N f aO N 1 OTrNO mOfN .~uimNNbinra0a~ O~ fvimOmCf 00^N OON1O .nNN1n .• . ~

^ N O~ N T • O N • r1 1[1 lp O • .'1 m • Al N~O - O N 1'1 1~O r O f N l.1 N T O~ o r r m O^ N N N T t 1

m . . ..tl . m . . . . O . .

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. N 9 •• • ••• •

O ^ .• . N~p N f~1 ^^~ N 1'f N N 1'1 ~!1 N! N N~r

t O o O o O O a O O O O O O O C O o o O C O o O O O O O O O O O O O o O O O o O O

o 0 0 ~. o o f o 0 0 o m o 0 0 0 0 0 0 0 1 G o 0 0 o a o 0 0 0 0 0 0 o a o G o 0 0

~O b•-+ m 1'1 r .A rf O N o1 .O O~ O•-•• ~•-• O1 .+ Q1 C~ •+ m m r A) r N m m f0 m N r .+ m v r N ~p

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N 1 v N n - O Of - m~n r f s N P'~ + 1-1 1-1 .•.

.•. ~I I f s r• rn N f .r m O a• r .n r•-~ ~ O Vt Q, O 1't .0

. . p . . .

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.

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1 •

1 O O O O O O O O O O O O O O O O O O O O

1 O O O O O O O O O O O^ a O O O o O O O O O O O O a O O O

. . . . .. . . . . .

1 N^ N m .. .n C N O N

.o <•a m r N a m m m m I O O O O O O O O O O O O O O O O O O O O

m r Nvt .O .+ v 1'1 N m .A ✓1 .+ .p N O~N!O r f m! ~^,

.+~+m v Nr.D .~r+rrN mr r• r .+

m 1'1 1 r a• ~O N N 1p f O,O f'1 O N m N! m m Ol ~O O

r+ f~O .•+ O~ 1p r1 r .O N ~f ~• f+ N m O~ t1 O m ul .r 1•f N f0 r r~'1 Y1 Q1 „1 T O 1.1 r N f 1D ~p t'1 f~l r m

m . . . . . . . . . . . ..

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m1 • •. . . . . .

Q 1 N l1 1fl ,O m G~ ~ . 1'1 Il1 vl 1[t .•e N 1G Qf ~ m! 1!1

N ••• •

Q N .••~ ti m„f 1.'1 .r N A ~1 f A A1 1'1 A1 .•r ul 1'f N'+

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

O O O O O o O O O O O r O C•n O O o O O O O O O O O O O O O C O O O . . . C C C

1 r f .•. r .+ O N O m a 1 r. rn O r O m .+ a N .- r 1 f.•+ O O r .+ f r T r v 1 N f m m O N m O ~ n

r .O I rl r f0 t0 f0 O f N u1 N N 1'1 O^ Yl N .+ N O m r N 1^ Q1 ~O ! m O r'lt N m O O~ ^ C1 N r 1'1 01 ul O

.+ 1 t'i r .OO „f fOO r rr a~ • C,N •C• .• . .•.mv1 ^t1 I f~o f r.+l+fmuY .•+Y1m ~+O++rr .-. f 1'1

m 1 . . . . . .. . . . O . . . . .

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Q N N~G r f r r~'1 f YI f^ A1 ul .•. m C1 Hl 1(1 N O N^ N 1(1 N f N N N 1'i PI T 1'f f 1f1 N 1fl P'7 PI ^

O O O O O O O O O O O O O O O O O O O O

1 O O O O O O O O O O O O a O O O m O O O O O O O O O O O O O O O O O O O O O O O

1 1'1,0 m O T1'f,OT Of0 ^41 .0 a,r-+'.v1r<1 .•~

I 0001"00 O 00001'fO000O O O O

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.e 3 3~ ~ay ,3C. YI`

A J! A G~, YA~z ~ J~ y 3 J~ Jr,/ v-, A Ji A~~

'- - - 'I -L7

--_~ r-- -
p. 58

Date 7 9_

MEMORANDU M

SQRO~'IvTR

77, r~--y! .j.,

oy - ~~

~-

Dr}y~ EN r ?' . 1 3 a,=,)c ~ .rY

fVI r.ry

4A t,oy Ak~ P . o?

Lot t 5r !`{ 1 3 C~ » z

rc-V ~ n! c

-~ So 3,3a

07. q/ ,3, l8'

Aoc, ~ yS 3.~5

n ,- ~ ~OoB

~A~1S r~ Fe✓ 1 ~ . .33 anr~ dr,t(o

LY►~1`] y F~ul ~. , o~ c~ ryC ~ . ~S

~Jn~ 1 ST~'~Y t`~ ► 3 Cc~~ z

+r-11 ! rtlc

3,06 ~l trS

orl

a ~s .3 .
59

Y VI f Vc t~cv I~vL f~vi r~c c~l rv~~ p ~

~~ t: Vl rV

~

E

,

L

r'

77-7 77 . ~ 1 .?z

~ .?7 o

)I ? .32 ~- .~l c2,2y 117

a .~S ~•`73 _' _`-

--

RVG

A~U o(•~ A~~ ~, ~ CYi1L

A~f ~ AV~ A A~< A VG A

~

~-EVI FVL FffVI FVL rEVI FyC FEUI VC FEVI FVC FEVI C. FrVI FVL

1Co~ ~

a•Vo~ ~Lz~~ z• ~~

~._.~2. L3 .o 0 a,2o ~~c3_ ~. a ~. ,TD o2 .3z 2,1 I

.211 dY/ 3,~ a.aS' 7~y 0 3? R 7z) ~2,v7 T

~`~ a sa 5 >

3 S ~• ~`~=-~° .~•7 2

.3

3L

AVr Ax, ~vG AV4 AX 11Jl~ qJc AV~ AJc AJG Ak qv~ nJ~ flv4

qj -'? •

~A fEUI FV<_ FEE VI FV~ V FVC F& V) FVC FEVI F~VC FE VI rVC FcVt 1= VC

j

~vc 1,_2& a.~ ~ 2 8 FE

~ ~z--0 0 a .37

-w a~ 7 gfo ~ a~2

3 C1 3 3S ~ __3L .7. o t i v ~~ 4 ~~~/

? --2-5 v lh

z o

3

7L ~=1 3-n?~-

3~

PA~~

~. 3 /

~q~ AJG

~/

AV AV~ AU /tJ4

DA~ ~~/ I VC '~ ~~ ---- . FEVI FVC FtVI `VC FrVl: FUC rCVI iVL FEVI FVs FtVI t'V C 2,/o J 3 2-7/ -2. ~l 3, _ ~~l a•9~l

04 ,V' ,3,0$ 7 0~ .

o

5

D//,/f 7 - -- ~i -7 0~, 7

--- - -L2~ ____ Pd4 AJG qV AVc, AV(, ~VS nu; AV < Jc,

"~S? ~~ 9/ -~t,a>/ ~L•l~ ~6? G

'

I ~• ~%b .`~r7 ~~7("0

O h ✓ S ~ V~ F

/ ~VI ,Fv~ ~I 1' F VC Fe V(

~ji

~. v~

~

F UC FG 'V I F v FVC f,(il) 3 77

0~ ")).SS

LI ... ?r~~.

~

7 9 5

A J JVl

1

AJ4 AJc, AV(, AJ4 A", A A4J~ w\v~ AJG AV~ A+VG AJ4

Dr:y ~ F~V L F,]C- FEVI VC- rcVl F ~C FEVI F~C FEui

?

F~JC F& Vt FVC Evl FL!

~_~I s5l 1 F') ,85 < -? - -) 5?~~ ~7. S'A,

~ ~ I ~,~ ~,~ R<f J•i5 sN ~ ~ d,~~ o~~ 3,09 ~

~ y) . I ~-, _~ ~•~g ~3:

AJ~, AJC,

J ._._ ~.G 7~ ~a . 8

_ ,J,zCa ~ _~S d~~~ ~~~~ ~•

J~ A~~' -/ C,S ~1V4 n UG ~ ~ r~V q ~ A Jc,

DhY

§4vc

~ rEVI FEVI F~' EF✓ FrV I FVC FEVI FVC

~ 3 ~ 3 y~5

~ o 5 r3

7coi 3

7 oz'~ ,2

fZI~'1 ~,3 Q-~ 33_ a ~ o 1,5--3 a- a~~Fl ~ 3~0 ~={ a,~rs ~,3"7 a .93 ~2 r 7 S ~~a Sf ~ G-' y(~ ~9 a, g 3 ~~~rc~ ~t--~

A AJ~ AJ~, AV 1V J AJG ;

o ~ '3 ~

I1VC, AV4

~

DA~/ FEVI FVC rGJ 1 FVC FEV! F VC FE vi FVC CV J FVL FEV I FVe V-IF VL ?~ 7 7 . ~ D ~4 4 57 1.rr 3r Z ^- .`ib 90

I~ g ~'SO f2 -rc~ r"- S~ ~ sr ( ~ .go~ 2.yk 1b~

--•~.

, 2k

2

.3< z I = 1-1 119

✓ y s' T C"- z, 7

AJC, P\ 4r- AJ4 A JG A ,)4 AV 4 AV~ AVC~ VC, AV~ AJS AJ4 l~JC, n,1 f .43 ~- 63 Z.y ~,Bg

_~,_

i.s 3 a~ Cl z t c _2 S 1 , n L 46 =•Y) 2 8

F60 F FLI t

~

rJC `EV V fEVt FVC f cVI rvC Fcvl rv1= Fc`Vt FVC

5'9 ' ~ 9 .2' r a,rS

) q 400

7 9 3

f

93 o75 a'1 ~

~

83

a,a(y ~ .rs a

2

a

r -a 5~ a.3 .

.? ,

A^4/ ~~~1 1JZ ,(0

aJsl ~~~Co ~Vl2f

~J4 AJ AJ~, :1 J

4~- arr ~ .~ a•~ ~•~1

-~- ~
p. 60

~{ rr,_vi fVl F

DA ! ~ _,(~ ,~ ~, o~/ - :.rl ~ ~ , ~•, :_, ..`'r J ;

~/ 7)( -5,

7) 7

~ 3. rr ,~ ,r r i .w ? '< ,,<<>r _ ~ ~

~= 1 ,~~~ _T~ ^S ~~. ~•

%~ -,-,i ` -r•-P_ -r

11 ~ _~ .Ir -~7 ~. jrs ,a>

1 TL ~, z?

•i r ~' ~~`l a .i ;; ~_ ;37 ~, ,~ ~3 _;

f

2 ~

A V(,, ,_ AV4

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I

FU(

- •rEV FY Fe V) VC, F~V FUC FEVI FJC F~VI FVC--

~3? " c~-ag 3r ~ ~ ? 13 3 ./~ .~~ (30 ~, 3,1L o .c7 /0 1

~j9 -,,b ~I,~~ ~,l) l/ ~t .C~ 7> '/ ', iJ //~ ~•3~ "~~/ S

y

3-11 (C~~71 ~ ~ / ; S~I 10-9

A v X , A~ av c. AV4 AJG AJG AJ~ AVG RJc Fl QC A J~ J , A Jc: AvC

-b 3,10 !r9 ~ .a 3 ~ 3Z2 b 3 - LO 3, 19

Fcvl Fv~7 EV UC Fc-V! ~7JC Evl ~VC rEVI F Fe VI FVC

-3 r',3 024 r>> r/ ~30 '( - ~?I,r l ~,r(G 3.

~ cy ~?,4a ?3 0 -7.3-- 3,2- 4. 3~ 3o51

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'

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- ----------- - - '- - - -- - - --- --~ _ • _ ~.___ . ., ..y1_ _

F~U UC, FcVi FV FtV F~VL ,F-tVl tVC FcVt F VL FEVI FUL EV VC, i S

3, z-,O 3 .1 7 s~ •S1 3•~

~ 3,0 -3 •(_,~ (ao 3, ? 53 56 a 9 a Y v o

~~ ~3 ~~~ -s~ 3,~Y a•~3 3 i a .9 ~~ 3,~ ~

aS oS o(~ -

~, S~I 3oS

3,i-3 ~ C2-co 31 3

. ..----

Z3 A. ~~. I\4, AJr~ s r1 r;j ~~~ L V'" A~) 3 J~

,

Ay5 FE '1 F,=VI FEV( V~ ~VI .FJ F-CVi FJC iCV I 1 uC 'F~VI FVC.

3,0o Y„~1 3.cz a,?3 ~,r~aZ.' j 3, zl o?.3C )~.~~a5 / 3,rs

3 ~1 ~a., ,~nfl YL ~

° ~

77 3 -3 a(~ 3 . r u5 ~ . °G 15 J 5S~

~"~ ~ ~'~~ j .,--•--. .. .

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~,Y> ~.~s Yl 3

----

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z ~z LI.

v ~•9 J. I 3,33 07.'7~ 3w7 Coo 3, o ~" ~,/

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Vj CYI V' -VI FVC r`ur J' FE~ v i FJC CVr FVC.~ FE

3 3,`~ ffc~, 0

~ s) 3,z/ ~,7r3 z.3 r ~Y c((o ~a/ - 71

p 1, .33 4,y7 3' r (o Z 37 3 a.s( 3~ 5a

3,31 / °~ ~ ____ ~ ~_. ._. ~ 2. 3 3 •

(~ 75

AJ AJG AJ r~VC J AJ A~4 AJc V, Rd AV4 A~;~, AJ4

~~~ , .2 .Yo 3 ./9 ~, ~S =,aZ a.3 3. 7.

----

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-

r

~

d~ ~~- v( FvC 1'c=u1 FVL FEUI FVe Fe VI 1" ~)C

2 .so 3. z .~ ( 3-2-3 a,SB 3 . ~ a_~v 3.zlv yy 3, 11- ~~Z 3,r9

2 .4-`I 3•r`f 1•1 3.3/ 3~ ~ ~ ~.5~- 3,Z _ . a

•LZ

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~ 3 .r z .~f8 3.1~ 2,S 3•? a

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(7f

.~

vl ~=dC EVI FVC fEV( Fv~ c v( VC- i~vl F' ~vr FVC

zg ) a a ,ri 3.aS a3~ 3•~ r,~ r•13,r 2- qz

d.9~ ~ aa ,~3g ~.''o~") 3, ,~ o,?v a .a~_~~2 kS~

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c00 _ , d , l 3ta o r

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r\JC AJ~ nJ` AJ~ AJ~' A~G Ad~ A A

~, r 3. t _J.39 3 -3- u 3
p. 61

` - - ' Date

MEMORANDUM

SQ(sUi/Ia-TR

D}y ) zx iE~ry 13 y, JG ~!y

917 r.t~

f o' 1 A r, o-- )

5-r /q13 c~ >> z

qr

A ac, ~ y Y 3. ~75

(~og

A .33 AFC

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~ 3y b ~~

--

a~- -L .ao b o~

: T~Ay 1 ST~~Y /y1~ Cc~~ Z

~l 1 ,=JG

3,a6 ~/.bS

3.oy or?

3 .59 3,7~

A1S 3,pq-- 5!03
I fV~ uC_ t'~ I~ ~L I~UI F~C rLVI '✓ ` Cvl i_ ~~~,~ I _ ~,~ ;~ .~ I : i . ~ p.62

~ I ~~ /. 5

.

r-~~--~ -~~ „~ ~,-~ i ~' ',

• ~~ ~ ~ 7 / -`%

-77

_ ~

, ~~1 J, 00

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~-

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VI 4

~ _~

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/Q"Cr Axi A V G r\ V4 Atk ~1~ E1~C A Ur, AVG Fl El 1k, [~ Jti A )C AVG

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-

E V I-----FVC- --~E- V 1 -FVC

- F-

EUF

---- -

C

-

V

-

I

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F V

. C

, - --- - - - - -

~EVI UC FEV F vL ~VC F FcVI FyC

A~ J 3, 4,13 3 , -1,61(o ~ `/ ~o ;~3 3,v? y, D Vic,

~ .s TW LE-7 Y,,3 _Ell

L j VV u i.= 3, YJ 7

Y=

J Ad~G Vti ~yV ~IJ -lo ~~~~ 3 Z~ 5

i VC FEV~ FVC FcvI r V L FrV FVC ~cVt FVC- re VI Fy FtV( FU(-'

~~ 3 .s~ ~

3-'~"a >

~d~ AJ A~ MCI A ' ~Jy

~ ~:~.~ ~ 5-~-., -~ ~ ~ • )

FEV,i F~c_ FEVI -

_

vC ~v I Fv~ FE V iF) C. FcJl Fvc F- III Fvc

DAy 5 3,z~ ~ ys 3~ SS 3, !3 ~Cvl~ y (c r,;9 3`)

3, ?~- r 7 i ~ L1 , ~ 3, 3 v 3. 3/ Y, G' 1

lrl 7,70-

55

NC, AJ~ AJC. AJc, AJ4 ~1J~ AV4 μ\V~ AVG h t!4 AJ4 AJG AJ4

0 3 33 y 7c

Dr+>' ~ ~EV1 F~C rr:v~ FFVC ~E V I F~c Fcui F ~1 .~ FcV FVe F EVj F

J` ----

3. f? ~ 3 3,✓ o 3.~0 /7q ~, ; ~/ 3.r7 IGl

~v y, .~ g 3 ~

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~70 y~ , ( , y,'71 _3Y7 Y &-?

1~1 0

AJ~, A JG JG /J~ ra ,~ J~~ G A r1 V ~'J- A~ R v A 4

~1~~ t=LVj FVC FCV I~ Fc~/~ Fe EE VI - C VI FVC FEV I

3~

~VC_

3~ 3,~5 yq (3t l( `/o~ 5!as ~ .~ y~a3

o ~ 5 ~s ?Fr

7s

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/~~ - 3 ~_- _l a .Cv~ l3•/~v) s~:s~ 4~. .✓ ~

3.b7 /

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DA r

' FEVI F7C rr- V

~

I FVC F"vl rVC Fe VI FvC r~uI Fv~ ,FEVI F y C. Fcui ~v

a ~`,~s9 . ~ 73 _3 ~l b~1 ~1 5, r l

3. 3 7 `

1 ~ 3

5 `'~ y, 7o fr~ ~

~

4,7

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A Qr_

3 J~ 3_~'3 ~ 70

~~}ir EC- VI FLVI r ~C~ FEV VC F EV i FVG F-cV ` . rV Ff VI FcVI_F ~

~0 3

j

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11 Y, Zi1 ~•~Z o 3 31)

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---- --,

g+~~2s ~,z~ yv
v~ rEVI rv - 'rEv~ ~~~f=~ ✓

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p

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3

5<<l/ ~ t- ~ ~~1 7••~C~ 3 ~ _3 .~s 3~0 3 .V1 > ~

EV r•UL FffVI FVL, EVI VC FEVI FVC_ F.EVI FYC FE I i-V C F rVl rJC

~ .~~) 1~ .~ 3,~ ~~ 1/l 5•~9

337 3~03 (~ S5 (771-- !

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3 3~

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~•~ ~ ~3 /-M S ro S~~ 5 G?o 5 .c3 5 Gy ~ ~ -0 5,50

7-773- ~7i o y ~ /

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~ nJ V•G u F1~ A r1JC, J~ A JG,

~c ~

r\Ju A, FtJ ~ S c, J1 c

- - -- - - - -51/0-- - -- -- - ---

~.i:V( t,VC V -

5

FEV.1 ~ Eul F✓ FEV ~ F VC F--JI FVC

Vr' 3S ^7,

IL-')3

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;. ,/o ~lZ

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y, 9 Sy7 ~ 3 ,o s5k' = ~4Z y,

~° :~ ._.

,

t.1\~VZ~ '~ AV4 AJ A

DA~/ ~ FEV} F VC r~-JI FVe F~v1 FE,VIFV~ FCVI V V ( "; r=tul F ✓ C FcU1 FJ~

3, T/ s('X, ~/~~ ~ zz ~3 s 5~ ~~

s oy ~ ~~ ~ T / y 7 T) t Y/ -77

777 ~~ 5o s•> yi3 s . S y7K > .~5 ~~o s s ~_ 7 11

AJG AJ AJ4 r1J Q ~V A ~J HUG Acl~ A~~ bJ4 AV

e`~ st 3 ~~`I ~ s~ ~ s •s~ y~~ s U ±~_°

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Y f_VI f VL F~J r I p. 64

( _ ~} 7,-c -77-

~_ 75 Sy1~ _ .~- {

A/

av~ A VS- A ,c. AJG nJ{, Au A J AV~j A~ AK ad~ nvy AV AY >~

~FEVI IUL FffVI FVL. rEVI FVC- tVl ~L> F e VI FVC- FEVI C IFrVI FV C-

.3 a, ,Y ?~. 3.~s J . 7X 5 .51 7 3~ 3 ~z U Iff

3 0?,~? S3 - 7J 3,3

71

a. ~

3 5 /

41 Avr r1 A Vc, AJG AJ, AJ(~ ACS A UG AJc, A QC Avc . qJ5 A A; qV~

3,5o SD J. C # ~, ?O 3. 5 7 .75 3 .5(0 J. 7`~ 3 .il3 Q,7,"0

~EUI FV,~:. F`EVt UC )EVI FUC FE-VI FJC. FEV ) F VC F`-VI FVC FEVI FVC

DA,~ 3 ,~~ 3.1~ (~. 3.i ~~ .~1 ~3.5 ~•~l 3 . IV 3,S`7 -2,fr'~

~,~Y 3.~1 a:~3 v~ 3, 7.~( 3~ 01•~3 77 ~-~- -~-- Y/

2 g3 3 3 ~, i

~~

5~12 - ---- _ _

J AJG I~Jc A V4()

v

5 ' AJ ~ J i~ JS J

.

r5 V1 F VC FEVi FVC FE ll FVC F-tVl F Ur rEVI FVL FEVI Fv FEV~ v'CC

DAy 3,C/ d.0 3,65 07,Y(- 3.SZf ~.9 3~ ~

•~_V 33 / ~. ~

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~ 3_ ~ ._}S 3 s .G

-- - __a--~_ ~ _ >~- 'S`~ -- --- -

~cV1 F~C F VI t VC- FcVI F FE V) T ~ JC F,~U F~ Ft Vf Ft1 F EVi F ~C

DA Y ?.9 V 3~ 3 .q) 3,

7 3

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FcVi rV~ F- II

V

cvI F✓ F~V~f~dG FeVf FVC- FEUI FVC

~S~ ~~~yn d-6y 7b 3a3~ a,~Sl 3 .3~~ ~.~ 3.~-S .2,1 5 3•_

~ 3~. i ~_ ~

~ ~. • Z .. ~ =7 3

-2 qL . 3 ~ kI 3 V ~ ~,g2 ~

AJG AJ 11V r1J~~ Jc AJ AVG e\ V: qV; AV 4

~ .z~ . ._ ~_ .~ ~ 3 ~ ~ ~ ~ ~

DA~

-- -~-- - FcVI FVC r~vi Fv~ ~~V1 r ✓C F~vt FvC~ ~EUI Fv3 . U-3-u FvC F& VI F U C

~ -2 ~ ~ 3 ~ 3,5~

c

r~

I •a.5' 3,~5 0 ' . r 3,C. "'% i,L ~~a ~ ?.`I"l >G~- -,05 3,I)L 71 3,W

Pv t~JG A ~Jc~ AVC A,,.)4 A A~ VC ~ A J' AuG AJ(~ AJc, A 0 4 r1J~ R1 d

~~ ~•~ o1 .~y ? ,~(~O c ~.~~

=

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~• ~3 ~,~~ ~ 3,

3, q,) J? 1

(\ ~ AJ 1' AJ~ qv MCI ~ 11J A ~ a AvG ~1 JC, AV q

3.(J~

~--_

---------------
I{~V t V~ .i

p.65

7/

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~U~•^~ ~- ~)

~

J ;~ ti "' J,')I oJ, } ✓ ~"T- T.T- ~ '7 ~ ._ .1<<

v~ >3 3 .cJ ._ .~5 1 ~ f 1 ~ 7 J. M, -E 7 /

/7 ~C /

RJG FkVC, K, l~ ~ _j A ✓ " ~- L~ 7 ~

J~ A

FEUI FVL F~VI FVL rEVI FVC. FtV! FVC FEV1 FVC:. EEV -JC~ F_VI VC

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DAY r 3, l~ 3y/y 3,7 ~- , -Cl ~, 1Y ~z 7.~ ~i7 3,7(~ o~ ~

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c ,(~S 1 ~-3~( 3~ ~,3Z ~~12 ~z8 3,~7 ~,z3 3do8 j,~ 7/

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DAY 7,3• >. Q 0. .5L 3,y( , -~f 7 ~ ~L~ C'•/ ., , 3J S' .05 3 7

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